WorldWideScience

Sample records for analysis final progress

  1. Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Josef Michl

    2011-10-31

    In this project we have established guidelines for the design on organic chromophores suitable for producing high triplet yields via singlet fission. We have proven their utility by identifying a chromophore of a structural class that had never been examined for singlet fission before, 1,3-diphenylisobenzofuran, and demonstrating in two independent ways that a thin layer of this material produces a triplet yield of 200% within experimental error. We have also designed a second chromophore of a very different type, again of a structural class that had not been examined for singlet fission before, and found that in a thin layer it produces a 70% triplet yield. Finally, we have enhanced the theoretical understanding of the quantum mechanical nature of the singlet fission process.

  2. Final Performance Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Houldin, Joseph [Delaware Valley Industrial Resource Center, Philadelphia, PA (United States); Saboor, Veronica [Delaware Valley Industrial Resource Center, Philadelphia, PA (United States)

    2016-03-30

    about assessing a company’s technical assets, broadening our view of the business to go beyond what they make or what NAICS code they have…to better understand their capacity, capability, and expertise, and to learn more about THEIR customers. Knowing more about the markets they serve can often provide insight into their level of technical knowledge and sophistication. Finally, in the spirit of realizing the intent of the Accelerator we strove to align and integrate the work and activities supported by the five funding agencies to leverage each effort. To that end, we include in the Integrated Work Plan a graphic that illustrates that integration. What follows is our summary report of the project, aggregated from prior reports.

  3. Final Progress Report for 'An Abstract Job Handling Grid Service for Dataset Analysis'

    International Nuclear Information System (INIS)

    David A Alexander

    2005-01-01

    For Phase I of the Job Handling project, Tech-X has built a Grid service for processing analysis requests, as well as a Graphical User Interface (GUI) client that uses the service. The service is designed to generically support High-Energy Physics (HEP) experimental analysis tasks. It has an extensible, flexible, open architecture and language. The service uses the Solenoidal Tracker At RHIC (STAR) experiment as a working example. STAR is an experiment at the Relativistic Heavy Ion Collider (RHIC) at the Brookhaven National Laboratory (BNL). STAR and other experiments at BNL generate multiple Petabytes of HEP data. The raw data is captured as millions of input files stored in a distributed data catalog. Potentially using thousands of files as input, analysis requests are submitted to a processing environment containing thousands of nodes. The Grid service provides a standard interface to the processing farm. It enables researchers to run large-scale, massively parallel analysis tasks, regardless of the computational resources available in their location

  4. IRIS Final Technical Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    M. D. Carelli

    2003-11-03

    OAK-B135 This NERI project, originally started as the Secure Transportable Autonomous Light Water Reactor (STAR-LW) and currently known as the International Reactor Innovative and Secure (IRIS) project, had the objective of investigating a novel type of water-cooled reactor to satisfy the Generation IV goals: fuel cycle sustainability, enhanced reliability and safety, and improved economics. The research objectives over the three-year (1999-2002) program were as follows: First year: Assess various design alternatives and establish main characteristics of a point design; Second year: Perform feasibility and engineering assessment of the selected design solutions; Third year: Complete reactor design and performance evaluation, including cost assessment These objectives were fully attained and actually they served to launch IRIS as a full fledged project for eventual commercial deployment. The program did not terminate in 2002 at the end of the NERI program, and has just entered in its fifth year. This has been made possible by the IRIS project participants which have grown from the original four member, two-countries team to the current twenty members, nine countries consortium. All the consortium members work under their own funding and it is estimated that the value of their in-kind contributions over the life of the project has been of the order of $30M. Currently, approximately 100 people worldwide are involved in the project. A very important constituency of the IRIS project is the academia: 7 universities from four countries are members of the consortium and five more US universities are associated via parallel NERI programs. To date, 97 students have worked or are working on IRIS; 59 IRIS-related graduate theses have been prepared or are in preparation, and 41 of these students have already graduated with M.S. (33) or Ph.D. (8) degrees. This ''final'' report (final only as far as the NERI program is concerned) summarizes the work performed

  5. 1995 PVUSA progress report. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Photovoltaics for Utility Scale Applications (PVUSA) is a national public-private partnership that is assessing and demonstrating the viability of utility-scale (US) photovoltaic (PV) electric generation systems and recent developments in PV module technology. This report updates the project`s progress, reviews the status and performance of the various PV installations during 1995, summarizes key accomplishments and conclusions, and serves as the final report under Pacific Gas and Electric Company`s project management.

  6. Chromosome region-specific libraries for human genome analysis. Final progress report, 1 March 1991--28 February 1994

    Energy Technology Data Exchange (ETDEWEB)

    Kao, F.T.

    1994-04-01

    The objectives of this grant proposal include (1) development of a chromosome microdissection and PCR-mediated microcloning technology, (2) application of this microtechnology to the construction of region-specific libraries for human genome analysis. During this grant period, the authors have successfully developed this microtechnology and have applied it to the construction of microdissection libraries for the following chromosome regions: a whole chromosome 21 (21E), 2 region-specific libraries for the long arm of chromosome 2, 2q35-q37 (2Q1) and 2q33-q35 (2Q2), and 4 region-specific libraries for the entire short arm of chromosome 2, 2p23-p25 (2P1), 2p21-p23 (2P2), 2p14-p16 (wP3) and 2p11-p13 (2P4). In addition, 20--40 unique sequence microclones have been isolated and characterized for genomic studies. These region-specific libraries and the single-copy microclones from the library have been used as valuable resources for (1) isolating microsatellite probes in linkage analysis to further refine the disease locus; (2) isolating corresponding clones with large inserts, e.g. YAC, BAC, P1, cosmid and phage, to facilitate construction of contigs for high resolution physical mapping; and (3) isolating region-specific cDNA clones for use as candidate genes. These libraries are being deposited in the American Type Culture Collection (ATCC) for general distribution.

  7. 23 CFR 140.609 - Progress and final vouchers.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Progress and final vouchers. 140.609 Section 140.609 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.609 Progress and final vouchers. (a) Progress vouchers may be...

  8. Hanford Site pollution prevention progress report; FINAL

    International Nuclear Information System (INIS)

    BETSCH, M.D.

    1999-01-01

    The Richland Operations Office (RL) and Office of River Protection (ORP) are pleased to issue the attached Pollution Prevention Progress Report. We have just met the most aggressive waste reduction and A recycling goals to date and are publishing this report to recognize A the site's progress, and to ensure it will sustain success beyond 1 Fiscal Year 2000. This report was designed to inform the been made by RL and ORP in Waste Minimization (WMin) and Pollution Prevention (P2). RL, ORP and their contractors are committed to protecting the environment, and we reiterate pollution prevention should continue to be at the forefront of the environmental cleanup and research efforts. As you read the attached report, we believe you will see a clear demonstration of RL and ORP's outstanding performance as it has been responsible and accountable to the nation, its employees, and the community in which we live and work. commitment that all employees have for environmental stewardship. The report provides useful information about the U.S. Department of Energy's (DOE'S) environmental policy and programs, and contains countless examples of waste minimization projects. This year was the first year our site received the White House Closing the Circle in the category of Affirmative Procurement. This Award recognizes our site for designing a comprehensive strategy for achieving 100 percent purchases of the U.S.Environmenta1 Protection Agency designated recycled items. DOE-Headquarters also acknowledged the site in 1999 for its public outreach efforts in communicating pollution prevention to Hanford Site employees and the community. Our site is truly a recognized leader in outreach as it has kept this title for two consecutive years. In previous years, we received the White House Closing the Circle Honorable Mention in Affirmative Procurement and several other National DOE Awards. Through partnership with the local community and stakeholders, the site and its contractors have a clear

  9. Studies in genetic discrimination. Final progress report

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    We have screened 1006 respondents in a study of genetic discrimination. Analysis of these responses has produced evidence of the range of institutions engaged in genetic discrimination and demonstrates the impact of this discrimination on the respondents to the study. We have found that both ignorance and policy underlie genetic discrimination and that anti-discrimination laws are being violated.

  10. Biorefinery Demonstration Project Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, David [University of Georgia Research Foundation, Inc., Athens, GA (United States)

    2015-10-20

    In this project we focused on various aspects of biorefinery technology development including algal-biorefinery technology, thermochemical conversion of biomass to bio-oils and biochar; we tested characteristics and applications of biochars and evaluated nutrient cycling with wastewater treatment by the coupling of algal culture systems and anaerobic digestion. Key results include a method for reducing water content of bio-oil through atomized alcohol addition. The effect included increasing the pH and reducing the viscosity and cloud point of the bio-oil. Low input biochar production systems were evaluated via literature reviews and direct experimental work. Additionally, emissions were evaluated and three biochar systems were compared via a life cycle analysis. Attached growth systems for both algal cultivation and algal harvesting were found to be superior to suspended growth cultures. Nutrient requirements for algal cultivation could be obtained by the recycling of anaerobic digester effluents, thus experimentally showing that these two systems could be directly coupled. Twenty-two journal articles and six intellectual property applications resulted from the cumulative work that this project contributed to programmatically.

  11. Schedulability Analysis for Java Finalizers

    DEFF Research Database (Denmark)

    Bøgholm, Thomas; Hansen, Rene Rydhof; Ravn, Anders P.

    2010-01-01

    Java finalizers perform clean-up and finalisation of objects at garbage collection time. In real-time Java profiles the use of finalizers is either discouraged (RTSJ, Ravenscar Java) or even disallowed (JSR-302), mainly because of the unpredictability of finalizers and in particular their impact ...... programs. Finally, we extend the SARTS tool for automated schedulability analysis of Java bytecode programs to handle finalizers in a fully automated way.......Java finalizers perform clean-up and finalisation of objects at garbage collection time. In real-time Java profiles the use of finalizers is either discouraged (RTSJ, Ravenscar Java) or even disallowed (JSR-302), mainly because of the unpredictability of finalizers and in particular their impact...... on the schedulability analysis. In this paper we show that a controlled scoped memory model results in a structured and predictable execution of finalizers, more reminiscent of C++ destructors than Java finalizers. Furthermore, we incorporate finalizers into a (conservative) schedulability analysis for Predictable Java...

  12. Schedulability Analysis for Java Finalizers

    DEFF Research Database (Denmark)

    Bøgholm, Thomas; Hansen, Rene Rydhof; Søndergaard, Hans

    2010-01-01

    Java finalizers perform clean-up and finalisation of objects at garbage collection time. In real-time Java profiles the use of finalizers is either discouraged (RTSJ, Ravenscar Java) or even disallowed (JSR-302), mainly because of the unpredictability of finalizers and in particular their impact...... on the schedulability analysis. In this paper we show that a controlled scoped memory model results in a structured and predictable execution of finalizers, more reminiscent of C++ destructors than Java finalizers. Furthermore, we incorporate finalizers into a (conservative) schedulability analysis for Predictable Java...... programs. Finally, we extend the SARTS tool for automated schedulability analysis of Java bytecode programs to handle finalizers in a fully automated way....

  13. Progressive methods in multiple criteria decision analysis

    OpenAIRE

    Meyer, Patrick

    2007-01-01

    Our work mainly focusses on the study and the development of progressive methods in the field of Multiple Criteria Decision Analysis, i.e., iterative procedures presenting partial conclusions to the Decision Maker that can be refined at further steps of the analysis. The thesis is divided into three parts. The first one is intended to be a general analysis of the concept of progressiveness. The last two parts develop progressive methods related first to Multiattribute Value Theory and sec...

  14. Integrated sequence analysis. Final report

    International Nuclear Information System (INIS)

    Andersson, K.; Pyy, P.

    1998-02-01

    The NKS/RAK subprojet 3 'integrated sequence analysis' (ISA) was formulated with the overall objective to develop and to test integrated methodologies in order to evaluate event sequences with significant human action contribution. The term 'methodology' denotes not only technical tools but also methods for integration of different scientific disciplines. In this report, we first discuss the background of ISA and the surveys made to map methods in different application fields, such as man machine system simulation software, human reliability analysis (HRA) and expert judgement. Specific event sequences were, after the surveys, selected for application and testing of a number of ISA methods. The event sequences discussed in the report were cold overpressure of BWR, shutdown LOCA of BWR, steam generator tube rupture of a PWR and BWR disturbed signal view in the control room after an external event. Different teams analysed these sequences by using different ISA and HRA methods. Two kinds of results were obtained from the ISA project: sequence specific and more general findings. The sequence specific results are discussed together with each sequence description. The general lessons are discussed under a separate chapter by using comparisons of different case studies. These lessons include areas ranging from plant safety management (design, procedures, instrumentation, operations, maintenance and safety practices) to methodological findings (ISA methodology, PSA,HRA, physical analyses, behavioural analyses and uncertainty assessment). Finally follows a discussion about the project and conclusions are presented. An interdisciplinary study of complex phenomena is a natural way to produce valuable and innovative results. This project came up with structured ways to perform ISA and managed to apply the in practice. The project also highlighted some areas where more work is needed. In the HRA work, development is required for the use of simulators and expert judgement as

  15. Integrated sequence analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, K.; Pyy, P

    1998-02-01

    The NKS/RAK subprojet 3 `integrated sequence analysis` (ISA) was formulated with the overall objective to develop and to test integrated methodologies in order to evaluate event sequences with significant human action contribution. The term `methodology` denotes not only technical tools but also methods for integration of different scientific disciplines. In this report, we first discuss the background of ISA and the surveys made to map methods in different application fields, such as man machine system simulation software, human reliability analysis (HRA) and expert judgement. Specific event sequences were, after the surveys, selected for application and testing of a number of ISA methods. The event sequences discussed in the report were cold overpressure of BWR, shutdown LOCA of BWR, steam generator tube rupture of a PWR and BWR disturbed signal view in the control room after an external event. Different teams analysed these sequences by using different ISA and HRA methods. Two kinds of results were obtained from the ISA project: sequence specific and more general findings. The sequence specific results are discussed together with each sequence description. The general lessons are discussed under a separate chapter by using comparisons of different case studies. These lessons include areas ranging from plant safety management (design, procedures, instrumentation, operations, maintenance and safety practices) to methodological findings (ISA methodology, PSA,HRA, physical analyses, behavioural analyses and uncertainty assessment). Finally follows a discussion about the project and conclusions are presented. An interdisciplinary study of complex phenomena is a natural way to produce valuable and innovative results. This project came up with structured ways to perform ISA and managed to apply the in practice. The project also highlighted some areas where more work is needed. In the HRA work, development is required for the use of simulators and expert judgement as

  16. Final Progress Report: SPECT Assay of Radiolabeled Monoclonal Antibodies

    International Nuclear Information System (INIS)

    Jaszczak, Ronald J.

    2004-01-01

    During the past project period, we proposed to collaborate closely with DOE's Thomas Jefferson National Accelerator Facility (Jefferson Lab or JLab) to design a compact, ultra-high-resolution, high-sensitivity gamma camera for quantifying brain-tumor distributions of I-131. We also proposed to continue our on-going research in developing and evaluating pinhole collimation for quantitative ultra-high-resolution imaging of I-131-labeled MAbs. We have made excellent progress in accomplishing much of the research related to pinhole collimation. Many of the most significant results have been presented in peer-reviewed journal articles and conference proceedings. We have also made good progress in collaborating with JLab's Detector Group in developing a compact, ultra-high-resolution, gamma camera. A prototype I-131 imager was delivered to Duke on May 28, 2003. Our research results are summarized in the following sections. A. JLAB-DUKE DEDICATED BRAIN-TUMOR IMAGING SYSTEM A.1. Determination of Optimal Collimator Design During the current project period a prototype I-131 dedicated brain imager has been designed and built. Computer simulations and analysis of alternate designs were performed at Duke to determine an optimal collimator design. Collimator response was characterized by spatial resolution and sensitivity. Both geometric (non-penetrative) and penetrative sensitivities were considered in selecting an optimal collimator design. Based on these simulation results, two collimator designs were selected and built by external vendors. Initial imaging results were obtained using these collimators. B. INITIAL DEVELOPMENT OF SPECT RECONSTRUCTION SOFTWARE FOR JLAB-DUKE CAMERA B.1. Modeling Thick Septa and Collimator Holes: Geometrical-Phantom Study A geometrical phantom was designed to illuminate spatial resolution effects. The phantom includes a uniformly attenuating medium that consists of all voxels within an elliptical cylinder that is centered on the axis of rotation

  17. Verification of Steelmaking Slags Iron Content Final Technical Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    J.Y. Hwang

    2006-10-04

    The steel industry in the United States generates about 30 million tons of by-products each year, including 6 million tons of desulfurization and BOF/BOP slag. The recycling of BF (blast furnace) slag has made significant progress in past years with much of the material being utilized as construction aggregate and in cementitious applications. However, the recycling of desulfurization and BOF/BOP slags still faces many technical, economic, and environmental challenges. Previous efforts have focused on in-plant recycling of the by-products, achieving only limited success. As a result, large amounts of by-products of various qualities have been stockpiled at steel mills or disposed into landfills. After more than 50 years of stockpiling and landfilling, available mill site space has diminished and environmental constraints have increased. The prospect of conventionally landfilling of the material is a high cost option, a waste of true national resources, and an eternal material liability issue. The research effort has demonstrated that major inroads have been made in establishing the viability of recycling and reuse of the steelmaking slags. The research identified key components in the slags, developed technologies to separate the iron units and produce marketable products from the separation processes. Three products are generated from the technology developed in this research, including a high grade iron product containing about 90%Fe, a medium grade iron product containing about 60% Fe, and a low grade iron product containing less than 10% Fe. The high grade iron product contains primarily metallic iron and can be marketed as a replacement of pig iron or DRI (Direct Reduced Iron) for steel mills. The medium grade iron product contains both iron oxide and metallic iron and can be utilized as a substitute for the iron ore in the blast furnace. The low grade iron product is rich in calcium, magnesium and iron oxides and silicates. It has a sufficient lime value and

  18. Nuclear Physics Laboratory, University of Colorado, Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, E.R., ed.

    2004-05-12

    OAK-B135 The results and progress of research funded by DOE grant number DOE-FG03-95ER40913 at the University of Colorado at Boulder is described. Includes work performed at the HERMES experiment at DESY to study the quark structure of the nucleon and the hadronization process in nuclei, as well as hadronic reactions studied at LAMPF, KEK, and Fermilab.

  19. Progress and Application of The Initial-Final Mass Relation

    Science.gov (United States)

    Cummings, Jeffrey D.

    2017-10-01

    The stellar life cycle is dominated by phases such as the hydrogen-burning stage and the remnant white dwarf cooling phase. However, between these two stages, stars dramatically transform themselves by losing the bulk of their mass. Planetary nebulae (PNe) provide a powerful clue to the processes involved in this transformation, but they are very complex. Over the past 15 years, a new wave of imaging and spectroscopy programs have uncovered the remnants of PNe, white dwarfs, in a wide range of well-measured environments. With this we can map the masses and temperatures of the stellar remnants to the properties of their progenitors. This work has now led to the first uniform mapping of the initial-final mass relation from 1.5 to 7 M⊙. The resulting relation is a fundamental input to our understanding of stellar evolution for low and intermediate-mass stars that produce PNe and has a wide range of applications.

  20. 1993 annual final progress report: July 1992 through June 1993

    Energy Technology Data Exchange (ETDEWEB)

    Rohatgi, A.; Crotty, G.; Chen, Z.; Sana, P.; Salami, J.; Doolittle, A.; Pang, A.; Pham, T. [Georgia Inst. of Tech., Atlanta, GA (United States). School of Electrical and Computer Engineering

    1994-11-01

    This is the first annual report since the Inauguration of the University Center of Excellence for Photovoltaics Research and Development (UCEP) at Georgia Tech. The essential objective of the Center is to improve the fundamental understanding of the science and technology of advanced PV devices and materials, to provide training and enrich the educational experience of students in the field, and to increase US competitiveness by providing guidelines to industry and DOE for achieving cost-effective and high efficiency PV devices. These objectives are to be accomplished through a combination of research and education. This report summarizes the technical accomplishments, including modeling, processing, and characterization of cast multicrystalline silicon solar cells; use of modeling and PCD measurements to develop a road map for progressing toward 20% multicrystalline and 25% single crystalline cells; the development of a novel PECVD SiN/SiO{sub 2} AR coating that also provides good surface passivation; PECVD deposited SiO{sub 2} films with record low S and D{sub it} at the SiO{sub 2}/Si interface; and educational activities and accomplishments.

  1. IRIS International Reactor Innovative and Secure Final Technical Progress Report

    International Nuclear Information System (INIS)

    Carelli, M.D.

    2003-01-01

    OAK-B135 This NERI project, originally started as the Secure Transportable Autonomous Light Water Reactor (STAR-LW) and currently known as the International Reactor Innovative and Secure (IRIS) project, had the objective of investigating a novel type of water-cooled reactor to satisfy the Generation IV goals: fuel cycle sustainability, enhanced reliability and safety, and improved economics. The research objectives over the three-year (1999-2002) program were as follows: First year: Assess various design alternatives and establish main characteristics of a point design; Second year: Perform feasibility and engineering assessment of the selected design solutions; Third year: Complete reactor design and performance evaluation, including cost assessment These objectives were fully attained and actually they served to launch IRIS as a full fledged project for eventual commercial deployment. The program did not terminate in 2002 at the end of the NERI program, and has just entered in its fifth year. This has been made possible by the IRIS project participants which have grown from the original four member, two-countries team to the current twenty members, nine countries consortium. All the consortium members work under their own funding and it is estimated that the value of their in-kind contributions over the life of the project has been of the order of $30M. Currently, approximately 100 people worldwide are involved in the project. A very important constituency of the IRIS project is the academia: 7 universities from four countries are members of the consortium and five more US universities are associated via parallel NERI programs. To date, 97 students have worked or are working on IRIS; 59 IRIS-related graduate theses have been prepared or are in preparation, and 41 of these students have already graduated with M.S. (33) or Ph.D. (8) degrees. This ''final'' report (final only as far as the NERI program is concerned) summarizes the work performed in the first four

  2. Advanced Fuel Cycle Initiative University Fellowship Program. Final Progress Report

    International Nuclear Information System (INIS)

    Dixon, Cathy

    2012-01-01

    2004-2011 Final Report for AFCI University Fellowship Program. The goal of this effort was to be supportive of university students and university programs - particularly those students and programs that will help to strengthen the development of nuclear-related fields. The program also supported the stability of the nuclear infrastructure and developed research partnerships that are helping to enlarge the national nuclear science technology base. In this fellowship program, the U.S. Department of Energy sought master's degree students in nuclear, mechanical, or chemical engineering, engineering/applied physics, physics, chemistry, radiochemistry, or fields of science and engineering applicable to the AFCI/Gen IV/GNEP missions in order to meet future U.S. nuclear program needs. The fellowship program identified candidates and selected full time students of high-caliber who were taking nuclear courses as part of their degree programs. The DOE Academic Program Managers encouraged fellows to pursue summer internships at national laboratories and supported the students with appropriate information so that both the fellows and the nation's nuclear energy objectives were successful.

  3. Final Report: Hydrogen Storage System Cost Analysis

    Energy Technology Data Exchange (ETDEWEB)

    James, Brian David [Strategic Analysis Inc., Arlington, VA (United States); Houchins, Cassidy [Strategic Analysis Inc., Arlington, VA (United States); Huya-Kouadio, Jennie Moton [Strategic Analysis Inc., Arlington, VA (United States); DeSantis, Daniel A. [Strategic Analysis Inc., Arlington, VA (United States)

    2016-09-30

    The Fuel Cell Technologies Office (FCTO) has identified hydrogen storage as a key enabling technology for advancing hydrogen and fuel cell power technologies in transportation, stationary, and portable applications. Consequently, FCTO has established targets to chart the progress of developing and demonstrating viable hydrogen storage technologies for transportation and stationary applications. This cost assessment project supports the overall FCTO goals by identifying the current technology system components, performance levels, and manufacturing/assembly techniques most likely to lead to the lowest system storage cost. Furthermore, the project forecasts the cost of these systems at a variety of annual manufacturing rates to allow comparison to the overall 2017 and “Ultimate” DOE cost targets. The cost breakdown of the system components and manufacturing steps can then be used to guide future research and development (R&D) decisions. The project was led by Strategic Analysis Inc. (SA) and aided by Rajesh Ahluwalia and Thanh Hua from Argonne National Laboratory (ANL) and Lin Simpson at the National Renewable Energy Laboratory (NREL). Since SA coordinated the project activities of all three organizations, this report includes a technical description of all project activity. This report represents a summary of contract activities and findings under SA’s five year contract to the US Department of Energy (Award No. DE-EE0005253) and constitutes the “Final Scientific Report” deliverable. Project publications and presentations are listed in the Appendix.

  4. Glaucoma Monitoring in a Clinical Setting Glaucoma Progression Analysis vs Nonparametric Progression Analysis in the Groningen Longitudinal Glaucoma Study

    NARCIS (Netherlands)

    Wesselink, Christiaan; Heeg, Govert P.; Jansonius, Nomdo M.

    Objective: To compare prospectively 2 perimetric progression detection algorithms for glaucoma, the Early Manifest Glaucoma Trial algorithm (glaucoma progression analysis [GPA]) and a nonparametric algorithm applied to the mean deviation (MD) (nonparametric progression analysis [NPA]). Methods:

  5. Final Technical Progress Report Long term risk from actinides in the environment: Modes of mobility; FINAL

    International Nuclear Information System (INIS)

    Thomas B. Kirchner

    2002-01-01

    in diameter and approximately 22 cm long. A thin ''marker layer'' of white soil was added to the top of each column followed by a thin layer of soil that had been spiked with 137Cs, cerium and lanthanum was applied to the surface. Approximately 900 cm of water (the equivalent of about 30 years of rainfall) was then applied at a rate of 3.2 L d-1. All of the activity contained in the soil core appeared to be in the top few mm of soil, i.e. there was virtually no movement of the 134Cs labeled particles. Finally, a library of object-oriented model components was created using Visual Basic to support the construction of contaminant transport models. These components greatly simplify the task of building 1- to 3- dimensional simulation models for risk assessment. The model components created under this funding were subsequently applied to help answer questions regarding risks from irrigation associated with potential releases from the Yucca Mountain waste repository

  6. Nano-Aptasensing in Mycotoxin Analysis: Recent Updates and Progress

    Directory of Open Access Journals (Sweden)

    Amina Rhouati

    2017-10-01

    Full Text Available Recent years have witnessed an overwhelming integration of nanomaterials in the fabrication of biosensors. Nanomaterials have been incorporated with the objective to achieve better analytical figures of merit in terms of limit of detection, linear range, assays stability, low production cost, etc. Nanomaterials can act as immobilization support, signal amplifier, mediator and artificial enzyme label in the construction of aptasensors. We aim in this work to review the recent progress in mycotoxin analysis. This review emphasizes on the function of the different nanomaterials in aptasensors architecture. We subsequently relate their features to the analytical performance of the given aptasensor towards mycotoxins monitoring. In the same context, a critically analysis and level of success for each nano-aptasensing design will be discussed. Finally, current challenges in nano-aptasensing design for mycotoxin analysis will be highlighted.

  7. Additional EIPC Study Analysis. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, Stanton W [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gotham, Douglas J. [Purdue Univ., West Lafayette, IN (United States); Luciani, Ralph L. [Navigant Consultant Inc., Suwanee, GA (United States)

    2014-12-01

    Between 2010 and 2012 the Eastern Interconnection Planning Collaborative (EIPC) conducted a major long-term resource and transmission study of the Eastern Interconnection (EI). With guidance from a Stakeholder Steering Committee (SSC) that included representatives from the Eastern Interconnection States Planning Council (EISPC) among others, the project was conducted in two phases. Phase 1 involved a long-term capacity expansion analysis that involved creation of eight major futures plus 72 sensitivities. Three scenarios were selected for more extensive transmission- focused evaluation in Phase 2. Five power flow analyses, nine production cost model runs (including six sensitivities), and three capital cost estimations were developed during this second phase. The results from Phase 1 and 2 provided a wealth of data that could be examined further to address energy-related questions. A list of 14 topics was developed for further analysis. This paper brings together the earlier interim reports of the first 13 topics plus one additional topic into a single final report.

  8. The Michigan high-level radioactive waste program: Final technical progress report

    International Nuclear Information System (INIS)

    1987-01-01

    This report comprises the state of Michigan's final technical report on the location of a proposed high-level radioactive waste disposal site. Included are a list of Michigan's efforts to review the DOE proposal and a detailed report on the application of geographic information systems analysis techniques to the review process

  9. Nonlinear Progressive Collapse Analysis Including Distributed Plasticity

    Directory of Open Access Journals (Sweden)

    Mohamed Osama Ahmed

    2016-01-01

    Full Text Available This paper demonstrates the effect of incorporating distributed plasticity in nonlinear analytical models used to assess the potential for progressive collapse of steel framed regular building structures. Emphasis on this paper is on the deformation response under the notionally removed column, in a typical Alternate Path (AP method. The AP method employed in this paper is based on the provisions of the Unified Facilities Criteria – Design of Buildings to Resist Progressive Collapse, developed and updated by the U.S. Department of Defense [1]. The AP method is often used for to assess the potential for progressive collapse of building structures that fall under Occupancy Category III or IV. A case study steel building is used to examine the effect of incorporating distributed plasticity, where moment frames were used on perimeter as well as the interior of the three dimensional structural system. It is concluded that the use of moment resisting frames within the structural system will enhance resistance to progressive collapse through ductile deformation response and that it is conserative to ignore the effects of distributed plasticity in determining peak displacement response under the notionally removed column.

  10. Systems analysis department annual progress report 1986

    International Nuclear Information System (INIS)

    Grohnheit, P.E.; Larsen, H.; Vestergaard, N.K.

    1987-02-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1986. The activities may be classified as energy systems analysis and risk and reliability analysis. The report includes a list of staff members. (author)

  11. Visual Progression Analysis of Student Records Data

    OpenAIRE

    Raji, Mohammad; Duggan, John; DeCotes, Blaise; Huang, Jian; Zanden, Bradley Vander

    2017-01-01

    University curriculum, both on a campus level and on a per-major level, are affected in a complex way by many decisions of many administrators and faculty over time. As universities across the United States share an urgency to significantly improve student success and success retention, there is a pressing need to better understand how the student population is progressing through the curriculum, and how to provide better supporting infrastructure and refine the curriculum for the purpose of ...

  12. Progressive Failure Analysis of Advanced Composites

    Science.gov (United States)

    2008-07-25

    continuum damage mechanics P.P. Camanho a,*, P. Maimı́ b, C.G. Dávila c a DEMEGI, Faculdade de Engenharia, Universidade do Porto , Rua Dr. Roberto...Progressive Damage in Bolted Composite Joints Hannes Koerber, Pedro P. Camanho DEMEGI, Faculdade de Engenharia, Universidade do Porto Rua Dr...Montilivi s/n, Girona, Spain bDEMEGI, Faculdade de Engenharia, Universidade do Porto , Rua Dr. Roberto Frias, 4200-465, Porto , Portugal Abstract This paper

  13. Applied Behavior Analysis is a Science and, Therefore, Progressive.

    Science.gov (United States)

    Leaf, Justin B; Leaf, Ronald; McEachin, John; Taubman, Mitchell; Ala'i-Rosales, Shahla; Ross, Robert K; Smith, Tristram; Weiss, Mary Jane

    2016-02-01

    Applied behavior analysis (ABA) is a science and, therefore, involves progressive approaches and outcomes. In this commentary we argue that the spirit and the method of science should be maintained in order to avoid reductionist procedures, stifled innovation, and rote, unresponsive protocols that become increasingly removed from meaningful progress for individuals diagnosed with autism spectrum disorder (ASD). We describe this approach as progressive. In a progressive approach to ABA, the therapist employs a structured yet flexible process, which is contingent upon and responsive to child progress. We will describe progressive ABA, contrast it to reductionist ABA, and provide rationales for both the substance and intent of ABA as a progressive scientific method for improving conditions of social relevance for individuals with ASD.

  14. Risk Analysis Group annual progress report 1984

    International Nuclear Information System (INIS)

    1985-06-01

    The activities of the Risk Analysis Group at Risoe during 1984 are presented. These include descriptions in some detail of work on general development topics and risk analysis performed as contractor. (author)

  15. Bedded-salt repository analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Guiffre, M.S.; Kaplan, M.F.; Ensminger, D.A.; Oston, S.G.; Nalbandian, J.Y.

    1980-03-31

    This report contains a description of an analysis of generic nuclear waste repository in bedded salt. This analysis was performed by TASC for inclusion in a major Lawrence Livermore Laboratory report to NRC; this report therefore should be viewed as providing more complete and detailed information about this analysis than was possible to include in the LLL report. The analysis is performed with the NUTRAN computer codes which are described in the report. The model to be analyzed is defined, and the results of a series of possible waste migration scenarios are presented. Several of these scenarios are used as the basis for a sensitivity analysis, and an uncertainty analysis utilizing Monte Carlo techniques is also performed. A new method for defining the consequences to users of a well drilled near the repository is also described, and results are presented based on two of the waste migration scenarios.

  16. Rawlins UCG Demonstration Project. Final technical progress report, January 1, 1987--February 9, 1988

    Energy Technology Data Exchange (ETDEWEB)

    1988-08-03

    Department of Energy Participation in the Rawlins UCG Demonstration Project began officially on November 9, 1987. Even though their financial participation began at this time, they will receive technical information from the start of the project which was on January 1, 1987. The Rawlins UCG Demonstration Project is progressing in Phase I with the majority of the emphasis on facility design, site characterization and the environmental work. The site characterization field work is estimated to be completed by the end of February with the final report completion towards the end of Phase I. The facility design effort is close to the 40% level. It is anticipated that all permits will be applied for in Phase I and most of them will be granted by the end of Phase I. The obtaining of the private financing continues to be a major activity in the project. All of the financing must be in place before the continuation for DOE funding to Phase II will be applied for.

  17. Systems Analysis Department annual progress report 1998

    DEFF Research Database (Denmark)

    1999-01-01

    The report describes the work of the Systems Analysis Department at Risø National Laboratory during 1998. The department undertakes research within Energy Systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, IndustrialSafety and Reliability, Man/Machine Interac....../Machine Interaction, and Technology Scenarios. The report includes lists of publications, lectures, committees and staff members....

  18. Systems Analysis Department annual progress report 1999

    DEFF Research Database (Denmark)

    2000-01-01

    This report describes the work of the Systems Analysis Department at Risø National Laboratory during 1999. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning - UNEP Centre, Safety,Realiability and Human Factors, and Technology...

  19. Systems Analysis department. Annual progress report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Petersen, Kurt E.

    1998-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1997. The department is undertaking research within Energy systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, Industrial Safety and Reliability and Man/Machine Interaction. The report includes lists of publications lectures, committees and staff members. (au) 110 refs.

  20. Systems Analysis Department annual progress report 1998

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Loevborg, Leif [eds.

    1999-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1998. The department undertakes research within Energy Systems Analysis, Integrated Energy, Environment and Development Planning - UNEP Centre, Industrial Safety and Reliability, Man/Machine Interaction and Technology Scenarios. The report includes lists of publications, lectures, committees and staff members. (au) 111 refs.

  1. Systems Analysis Department. Annual Progress Report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Hans; Olsson, Charlotte; Loevborg, Leif [eds.

    2000-03-01

    This report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1999. The department is undertaking research within Energy Systems Analysis, Energy, Environment and Development Planning-UNEP Centre, Safety, Reliability and Human Factors, and Technology Scenarios. The report includes summary statistics and lists of publications, committees and staff members. (au)

  2. Progress report on the AMT analysis

    International Nuclear Information System (INIS)

    Wood, B.

    1992-01-01

    ICF Resources Incorporated's analysis of the Alternative Minimum Tax (AMT) has examined its effect on the US oil and gas industry from several different perspectives, to estimate the effect of the three relief proposals and to better understand the source of the outcry about the AMTs ''inequities.'' This report is a brief summary of the methodology and results to date. The complexity of the accounting mechanisms that comprise the AMT and the disparity between this analytical conclusions and clauses made by the oil and gas industry (principally the IPAA) have led this analysis through several distinct phases of: Project-level analysis; firm-level analysis; and demographic analysis. These analyses are described in detail

  3. The latest progress of fission track analysis

    International Nuclear Information System (INIS)

    Wang Shicheng

    1996-01-01

    Fission track analysis as a new nuclear track technique is based on fission track annealing in mineral and is used for oil and gas exploration successfully. The west part of China is the main exploration for oil and gas. The oil and gas basins there experienced much more complicated thermal history and higher paleotemperature. In order to apply fission track analysis to these basins, following work was be carried out: 1. The decomposition of grain age distribution of zircon fission tracks. 2. Study on thermal history of Ordos basin using zircon fission track analysis. 3. The fission track study on the Qiang Tang basin in tibet

  4. Progress in spatial analysis methods and applications

    CERN Document Server

    Páez, Antonio; Buliung, Ron N; Dall'erba, Sandy

    2010-01-01

    This book brings together developments in spatial analysis techniques, including spatial statistics, econometrics, and spatial visualization, and applications to fields such as regional studies, transportation and land use, population and health.

  5. Errors of DWPF frit analysis: Final report

    International Nuclear Information System (INIS)

    Schumacher, R.F.

    1993-01-01

    Glass frit will be a major raw material for the operation of the Defense Waste Processing Facility. The frit will be controlled by certificate of conformance and a confirmatory analysis from a commercial analytical laboratory. The following effort provides additional quantitative information on the variability of frit chemical analyses at two commercial laboratories. Identical samples of IDMS Frit 202 were chemically analyzed at two commercial laboratories and at three different times over a period of four months. The SRL-ADS analyses, after correction with the reference standard and normalization, provided confirmatory information, but did not detect the low silica level in one of the frit samples. A methodology utilizing elliptical limits for confirming the certificate of conformance or confirmatory analysis was introduced and recommended for use when the analysis values are close but not within the specification limits. It was also suggested that the lithia specification limits might be reduced as long as CELS is used to confirm the analysis

  6. Systems Analysis Department. Annual progress report 1996

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, H.; Olsson, C.; Petersen, K.E. [eds.

    1997-03-01

    The report describes the work of the Systems Analysis Department at Risoe National Laboratory during 1996. The department is undertaking research within Simulation and Optimisation of Energy Systems, Energy and Environment in Developing Countries - UNEP Centre, Integrated Environmental and Risk Management and Man/Machine Interaction. The report includes lists of publications, lectures, committees and staff members. (au) 131 refs.

  7. Thermoeconomic analysis of power plants. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Tsatsaronis, G.; Winhold, M.

    1984-08-01

    In this report, the concept of exergy and the general methodology of the exergetic analysis and the thermoeconomic (combined exergetic and economic) analysis of energy conversion systems are presented. The THESIS (THermodynamic and Economc SImulation System) computer program used for these analyses is briefly described. Detailed mass, energy, exergy and money balances for a reference steam power plant (Harry Allen Station) are shown. The effect of the most important process parameters on the overall efficiency is investigated. A year-by-year and a levelized revenue requirement analysis are presented. The costs of exergy losses are compared with the capital costs and other expenses due to owning and operating each particular plant component. The question whether it is profitable to reduce the exergy losses by increasing these costs and vice versa is investigated. A cost sensitivity analysis including the effect of coal price and average annual capacity factor is performed. The methodology applied in this report appears to be useful in analyzing and evaluating energy conversion systems. The analyses presented here allow identification and evaluation of the inefficiencies and the opportunities for improvement of an energy conversion process. Results indicate that modifications in certain process parameters can lead to a decrease in the cost of electricity produced by the reference plant.

  8. Improved methods for water shutoff. Final technical progress report, October 1, 1997--September 30, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Seright, R.S.; Liang, J.T.; Schrader, R.; Hagstrom, J. II; Liu, J.; Wavrik, K.

    1998-10-01

    In the United States, more than 20 billion barrels of salt water are produced each year during oilfield operations. A tremendous economic incentive exists to reduce water production if that can be accomplished without significantly sacrificing hydrocarbon production. This three-year research project had three objectives. The first objective was to identify chemical blocking agents that will (a) during placement, flow readily through fractures without penetrating significantly into porous rock and with screening out or developing excessive pressure gradients and (b) at a predictable and controllable time, become immobile and resistant breakdown upon exposure to moderate to high pressure gradients. The second objective was to identify schemes that optimize placement of the above blocking agents. The third objective was to explain why gels and other chemical blocking agents reduce permeability to one phase (e.g., water) more than that to another phase (e.g., oil or gas). The authors also wanted to identify conditions that maximize this phenomenon. This project consisted of three tasks, each of which addressed one of the above objectives. This report describes work performed during the third and final period of the project. During this three-year project, they: (1) Developed a procedure and software for sizing gelant treatments in hydraulically fractured production wells; (2) Developed a method (based on interwell tracer results) to determine the potential for applying gel treatments in naturally fractured reservoirs; (3) Characterized gel properties during extrusion through fractures; (4) Developed a method to predict gel placement in naturally fractured reservoirs; (5) Made progress in elucidating the mechanism for why some gels can reduce permeability to water more than that to oil; (6) Demonstrated the limitations of using water/oil ratio diagnostic plots to distinguish between channeling and coning; and (7) Proposed a philosophy for diagnosing and attacking water

  9. Final Technical Progress Report: Development of Low-Cost Suspension Heliostat; December 7, 2011 - December 6, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Bender, W.

    2013-01-01

    Final technical progress report of SunShot Incubator Solaflect Energy. The project succeeded in demonstrating that the Solaflect Suspension Heliostat design is viable for large-scale CSP installations. Canting accuracy is acceptable and is continually improving as Solaflect improves its understanding of this design. Cost reduction initiatives were successful, and there are still many opportunities for further development and further cost reduction.

  10. Dynamics and vibrations progress in nonlinear analysis

    CERN Document Server

    Kachapi, Seyed Habibollah Hashemi

    2014-01-01

    Dynamical and vibratory systems are basically an application of mathematics and applied sciences to the solution of real world problems. Before being able to solve real world problems, it is necessary to carefully study dynamical and vibratory systems and solve all available problems in case of linear and nonlinear equations using analytical and numerical methods. It is of great importance to study nonlinearity in dynamics and vibration; because almost all applied processes act nonlinearly, and on the other hand, nonlinear analysis of complex systems is one of the most important and complicated tasks, especially in engineering and applied sciences problems. There are probably a handful of books on nonlinear dynamics and vibrations analysis. Some of these books are written at a fundamental level that may not meet ambitious engineering program requirements. Others are specialized in certain fields of oscillatory systems, including modeling and simulations. In this book, we attempt to strike a balance between th...

  11. Manpower analysis in transportation safety. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, C.S.; Bowden, H.M.; Colford, C.A.; DeFilipps, P.J.; Dennis, J.D.; Ehlert, A.K.; Popkin, H.A.; Schrader, G.F.; Smith, Q.N.

    1977-05-01

    The project described provides a manpower review of national, state and local needs for safety skills, and projects future manning levels for transportation safety personnel in both the public and private sectors. Survey information revealed that there are currently approximately 121,000 persons employed directly in transportation safety occupations within the air carrier, highway and traffic safety, motor carrier, pipeline, rail carrier, and marine carrier transportation industry groups. The projected need for 1980 is over 145,000 of which over 80 percent will be in highway safety. An analysis of transportation tasks is included, and shows ten general categories about which the majority of safety activities are focused. A skills analysis shows a generally high level of educational background and several years of experience are required for most transportation safety jobs. An overall review of safety programs in the transportation industry is included, together with chapters on the individual transportation modes.

  12. Final report on the Pathway Analysis Task

    Energy Technology Data Exchange (ETDEWEB)

    Whicker, F.W.; Kirchner, T.B. [Colorado State Univ., Fort Collins, CO (United States)

    1993-04-01

    The Pathway Analysis Task constituted one of several multi-laboratory efforts to estimate radiation doses to people, considering all important pathways of exposure, from the testing of nuclear devices at the Nevada Test Site (NTS). The primary goal of the Pathway Analysis Task was to predict radionuclide ingestion by residents of Utah, Nevada, and portions of seven other adjoining western states following radioactive fallout deposition from individual events at the NTS. This report provides comprehensive documentation of the activities and accomplishments of Colorado State University`s Pathway Analysis Task during the entire period of support (1979--91). The history of the project will be summarized, indicating the principal dates and milestones, personnel involved, subcontractors, and budget information. Accomplishments, both primary and auxiliary, will be summarized with general results rather than technical details being emphasized. This will also serve as a guide to the reports and open literature publications produced, where the methodological details and specific results are documented. Selected examples of results on internal dose estimates are provided in this report because the data have not been published elsewhere.

  13. Final report on the Pathway Analysis Task

    International Nuclear Information System (INIS)

    Whicker, F.W.; Kirchner, T.B.

    1993-04-01

    The Pathway Analysis Task constituted one of several multi-laboratory efforts to estimate radiation doses to people, considering all important pathways of exposure, from the testing of nuclear devices at the Nevada Test Site (NTS). The primary goal of the Pathway Analysis Task was to predict radionuclide ingestion by residents of Utah, Nevada, and portions of seven other adjoining western states following radioactive fallout deposition from individual events at the NTS. This report provides comprehensive documentation of the activities and accomplishments of Colorado State University's Pathway Analysis Task during the entire period of support (1979--91). The history of the project will be summarized, indicating the principal dates and milestones, personnel involved, subcontractors, and budget information. Accomplishments, both primary and auxiliary, will be summarized with general results rather than technical details being emphasized. This will also serve as a guide to the reports and open literature publications produced, where the methodological details and specific results are documented. Selected examples of results on internal dose estimates are provided in this report because the data have not been published elsewhere

  14. Biologic considerations in anatomic imaging with radionuclides. Final progress report, July 1974--June 1975

    International Nuclear Information System (INIS)

    Potchen, E.J.

    1975-01-01

    An important task relating to anatomic imaging with radionuclides is the determination of factors which effect the use of imaging procedures. This is important to reduce radiation exposure in the population, to improve the efficacy of diagnostic imaging procedures and finally to provide a basis for evaluating the potential effects of proposed regulation of use rates. In this report we describe a methodology for obtaining clinical data relating to the use of the brain scan in an inner city teaching hospital. The development of a questionnaire suitable for use in a clinical setting and providing both prospective and retrospective data is presented. The results of the use of the questionnaire at the Johns Hopkins Hospital during a three month period in 1974 are shown and discussed. Some preliminary results from these data are given and a method for further analysis is indicated

  15. High-Efficiency Nitride-Based Solid-State Lighting. Final Technical Progress Report

    International Nuclear Information System (INIS)

    Paul T. Fini; Shuji Nakamura

    2005-01-01

    In this final technical progress report we summarize research accomplished during Department of Energy contract DE-FC26-01NT41203, entitled ''High-Efficiency Nitride-Based Solid-State Lighting''. Two teams, from the University of California at Santa Barbara (Principle Investigator: Dr. Shuji Nakamura) and the Lighting Research Center at Rensselaer Polytechnic Institute (led by Dr. N. Narendran), pursued the goals of this contract from thin film growth, characterization, and packaging/luminaire design standpoints. The UCSB team initially pursued the development of blue gallium nitride (GaN)-based vertical-cavity surface-emitting lasers, as well as ultraviolet GaN-based light emitting diodes (LEDs). In Year 2, the emphasis shifted to resonant-cavity light emitting diodes, also known as micro-cavity LEDs when extremely thin device cavities are fabricated. These devices have very directional emission and higher light extraction efficiency than conventional LEDs. Via the optimization of thin-film growth and refinement of device processing, we decreased the total cavity thickness to less than 1 (micro)m, such that micro-cavity effects were clearly observed and a light extraction efficiency of over 10% was reached. We also began the development of photonic crystals for increased light extraction, in particular for so-called ''guided modes'' which would otherwise propagate laterally in the device and be re-absorbed. Finally, we pursued the growth of smooth, high-quality nonpolar a-plane and m-plane GaN films, as well as blue light emitting diodes on these novel films. Initial nonpolar LEDs showed the expected behavior of negligible peak wavelength shift with increasing drive current. M-plane LEDs in particular show promise, as unpackaged devices had unsaturated optical output power of ∼ 3 mW at 200 mA drive current. The LRC's tasks were aimed at developing the subcomponents necessary for packaging UCSB's light emitting diodes, and packaging them to produce a white light

  16. Regulatory analysis technical evaluation handbook. Final report

    International Nuclear Information System (INIS)

    1997-01-01

    The purpose of this Handbook is to provide guidance to the regulatory analyst to promote preparation of quality regulatory analysis documents and to implement the policies of the Regulatory Analysis Guidelines of the US Nuclear Regulatory Commission (NUREG/BR-0058 Rev. 2). This Handbook expands upon policy concepts included in the NRC Guidelines and translates the six steps in preparing regulatory analyses into implementable methodologies for the analyst. It provides standardized methods of preparation and presentation of regulatory analyses, with the inclusion of input that will satisfy all backfit requirements and requirements of NRC's Committee to Review Generic Requirements. Information on the objectives of the safety goal evaluation process and potential data sources for preparing a safety goal evaluation is also included. Consistent application of the methods provided here will result in more directly comparable analyses, thus aiding decision-makers in evaluating and comparing various regulatory actions. The handbook is being issued in loose-leaf format to facilitate revisions. NRC intends to periodically revise the handbook as new and improved guidance, data, and methods become available

  17. Regulatory analysis technical evaluation handbook. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    The purpose of this Handbook is to provide guidance to the regulatory analyst to promote preparation of quality regulatory analysis documents and to implement the policies of the Regulatory Analysis Guidelines of the US Nuclear Regulatory Commission (NUREG/BR-0058 Rev. 2). This Handbook expands upon policy concepts included in the NRC Guidelines and translates the six steps in preparing regulatory analyses into implementable methodologies for the analyst. It provides standardized methods of preparation and presentation of regulatory analyses, with the inclusion of input that will satisfy all backfit requirements and requirements of NRC`s Committee to Review Generic Requirements. Information on the objectives of the safety goal evaluation process and potential data sources for preparing a safety goal evaluation is also included. Consistent application of the methods provided here will result in more directly comparable analyses, thus aiding decision-makers in evaluating and comparing various regulatory actions. The handbook is being issued in loose-leaf format to facilitate revisions. NRC intends to periodically revise the handbook as new and improved guidance, data, and methods become available.

  18. Organic analysis progress report FY 1997

    International Nuclear Information System (INIS)

    Clauss, S.A.; Grant, K.E.; Hoopes, V.; Mong, G.M.; Steele, R.; Bellofatto, D.; Sharma, A.

    1998-04-01

    The Organic Analysis and Methods Development Task is being conducted by Pacific Northwest National Laboratory (PNNL) as part of the Organic Tank Waste Safety Project. The objective of the task is to apply developed analytical methods to identify and/or quantify the amount of particular organic species in tank wastes. In addition, this task provides analytical support for the Gas Generation Studies Task, Waste Aging, and Solubility Studies. This report presents the results from analyses of tank waste samples archived at Pacific Northwest National Laboratory (PNNL) and received from the Project Hanford Management Contractor (PHMC), which included samples associated with both the Flammable Gas and Organic Tank Waste Safety Programs. The data are discussed in Section 2.0. In addition, the results of analytical support for analyzing (1) simulated wastes for Waste Aging, (2) tank waste samples for Gas Generation, and (3) simulated wastes associated with solubility studies discussed in Sections 3.0, 4.0, and 5.0, respectively. The latter part of FY 1997 was devoted to documenting the analytical procedures, including derivation gas chromatography/mass spectrometry (GC/MS) and GC/FID for quantitation, ion-pair chromatography (IPC), IC, and the cation exchange procedure for reducing the radioactivity of samples. The documentation of analytical procedures is included here and discussed in Section 6.0 and Section 7.0 discusses other analytical procedures. The references are listed in Section 8.0 and future plans are discussed in Section 9.0. Appendix A is a preprint of a manuscript accepted for publication. Appendix B contains the cc mail messages and chain-of-custody forms for the samples received for analyses. Appendix C contains the test plan for analysis of tank waste samples

  19. Organic analysis progress report FY 1997

    Energy Technology Data Exchange (ETDEWEB)

    Clauss, S.A.; Grant, K.E.; Hoopes, V.; Mong, G.M.; Steele, R.; Bellofatto, D.; Sharma, A.

    1998-04-01

    The Organic Analysis and Methods Development Task is being conducted by Pacific Northwest National Laboratory (PNNL) as part of the Organic Tank Waste Safety Project. The objective of the task is to apply developed analytical methods to identify and/or quantify the amount of particular organic species in tank wastes. In addition, this task provides analytical support for the Gas Generation Studies Task, Waste Aging, and Solubility Studies. This report presents the results from analyses of tank waste samples archived at Pacific Northwest National Laboratory (PNNL) and received from the Project Hanford Management Contractor (PHMC), which included samples associated with both the Flammable Gas and Organic Tank Waste Safety Programs. The data are discussed in Section 2.0. In addition, the results of analytical support for analyzing (1) simulated wastes for Waste Aging, (2) tank waste samples for Gas Generation, and (3) simulated wastes associated with solubility studies discussed in Sections 3.0, 4.0, and 5.0, respectively. The latter part of FY 1997 was devoted to documenting the analytical procedures, including derivation gas chromatography/mass spectrometry (GC/MS) and GC/FID for quantitation, ion-pair chromatography (IPC), IC, and the cation exchange procedure for reducing the radioactivity of samples. The documentation of analytical procedures is included here and discussed in Section 6.0 and Section 7.0 discusses other analytical procedures. The references are listed in Section 8.0 and future plans are discussed in Section 9.0. Appendix A is a preprint of a manuscript accepted for publication. Appendix B contains the cc mail messages and chain-of-custody forms for the samples received for analyses. Appendix C contains the test plan for analysis of tank waste samples.

  20. User-Defined Material Model for Progressive Failure Analysis

    Science.gov (United States)

    Knight, Norman F. Jr.; Reeder, James R. (Technical Monitor)

    2006-01-01

    An overview of different types of composite material system architectures and a brief review of progressive failure material modeling methods used for structural analysis including failure initiation and material degradation are presented. Different failure initiation criteria and material degradation models are described that define progressive failure formulations. These progressive failure formulations are implemented in a user-defined material model (or UMAT) for use with the ABAQUS/Standard1 nonlinear finite element analysis tool. The failure initiation criteria include the maximum stress criteria, maximum strain criteria, the Tsai-Wu failure polynomial, and the Hashin criteria. The material degradation model is based on the ply-discounting approach where the local material constitutive coefficients are degraded. Applications and extensions of the progressive failure analysis material model address two-dimensional plate and shell finite elements and three-dimensional solid finite elements. Implementation details and use of the UMAT subroutine are described in the present paper. Parametric studies for composite structures are discussed to illustrate the features of the progressive failure modeling methods that have been implemented.

  1. Final Report on Models, Periodic Progress, Report No D1.3, Globeman21, ESPRIT 26509

    DEFF Research Database (Denmark)

    Pedersen, Jens Dahl; Tølle, Martin; Vesterager, Johan

    1999-01-01

    This deliverable D1.3 is the third and final deliverable of WP1 - Global Manufacturing Concept of the European part of the Globeman21 project. The report essentially presents the final models on generic Extended Enterprise Management (EEM) and generic Product Life Cycle Management (PLCM), a colle...

  2. Applied Behavior Analysis Is a Science And, Therefore, Progressive

    Science.gov (United States)

    Leaf, Justin B.; Leaf, Ronald; McEachin, John; Taubman, Mitchell; Ala'i-Rosales, Shahla; Ross, Robert K.; Smith, Tristram; Weiss, Mary Jane

    2016-01-01

    Applied behavior analysis (ABA) is a science and, therefore, involves progressive approaches and outcomes. In this commentary we argue that the spirit and the method of science should be maintained in order to avoid reductionist procedures, stifled innovation, and rote, unresponsive protocols that become increasingly removed from meaningful…

  3. Analysis of breast cancer progression using principal component ...

    Indian Academy of Sciences (India)

    PRAKASH KUMAR

    We use this set of genes and a new consensus ensemble k-clustering technique, which averages over several clustering methods and many data perturbations, to identify strong, stable clusters. We also define a simple criterion to find the optimum number of. Analysis of breast cancer progression using principal component.

  4. FINAL Progress Report DOE Grant DE-FG02-04ER15587

    Energy Technology Data Exchange (ETDEWEB)

    Mullins, Charles Buddie [Univ. of Texas, Austin, TX (United States)

    2016-11-03

    Catalysis Program - Viviane Schwartz Program Manager This Final Report discusses several archival journal articles that have been published that present and discuss the results that were discovered through this DOE grant.

  5. Ultraviolet irradiation of nucleic acids and related compounds. Final progress report

    International Nuclear Information System (INIS)

    Wang, S.Y.

    1976-01-01

    Progress is reported on the following research projects: photohydration of pyrimidine derivatives; thymine dimerization; uv-induced formation of pyrimidinyl radicals; formation of a coupled product by irradiation of 5-bromouracil derivatives; studies on pyrimidine adducts; molecular aggregates-puddle formation hypothesis of pyrimidine photodimerization; and topochemical studies of structures of dimers and of crystalline arrangements

  6. Development of Career Progression Systems for Employees in the Foodservice Industry. Final Report.

    Science.gov (United States)

    National Restaurant Association, Chicago, IL.

    Firms representing four segments of the foodservice industry (institutional foodservice (9 jobs), commercial restaurants (19 jobs), hotel foodservice (100 jobs), and airline foodservice (10 jobs), participated in a career and training study to test the feasibility of designing and implementing career progression (c.p.) systems within these…

  7. Analysis of the Correlation between GDP and the Final Consumption

    Directory of Open Access Journals (Sweden)

    Constantin ANGHELACHE

    2011-09-01

    Full Text Available This paper presents the results of the researches performed by the author regarding the evolution of Gross Domestic Product. One of the main aspects of GDP analysis is the correlation with the final consumption, an important macroeconomic indicator. The evolution of the Gross Domestic Product is highly influenced by the evolution of the final consumption. To analyze the correlation, the paper proposes the use of the linear regression model, as one of the most appropriate instruments for such scientific approach. The regression model described in the article uses the GDP as resultant variable and the final consumption as factorial variable.

  8. Processes of energy deposition by heavy-particle and electron impact. Final progress report

    International Nuclear Information System (INIS)

    Salop, A.; Smith, F.T.

    1978-01-01

    Progress is reported in three areas of reasearch during the present period: K-shell ionization in high energy collisions of heavy ions with light target atoms using the sudden (Magnus) approximation, K-L level matching phenomena associated with K-shell vacancy production in heavy-ion collisions, and studies of low energy collisions of electrons with molecules using semi-classical perturbation theory. A brief discussion of each of these activities is given

  9. Biomedical Computing Technology Information Center (BCTIC): Final progress report, March 1, 1986-September 30, 1986

    International Nuclear Information System (INIS)

    1987-01-01

    During this time, BCTIC packaged and disseminated computing technology and honored all requests made before September 1, 1986. The final month of operation was devoted to completing code requests, returning submitted codes, and sending out notices of BCTIC's termination of services on September 30th. Final BCTIC library listings were distributed to members of the active mailing list. Also included in the library listing are names and addresses of program authors and contributors in order that users may have continued support of their programs. The BCTIC library list is attached

  10. Experimental and Theoretical Progress of Linear Collider Final Focus Design and ATF2 Facility

    CERN Document Server

    Seryi, Andrei; Zimmermann, Frank; Kubo, Kiyoshi; Kuroda, Shigeru; Okugi, Toshiyuki; Tauchi, Toshiaki; Terunuma, Nobuhiro; Urakawa, Junji; White, Glen; Woodley, Mark; Angal-Kalinin, Deepa

    2014-01-01

    In this brief overview we will reflect on the process of the design of the linear collider (LC) final focus (FF) optics, and will also describe the theoretical and experimental efforts on design and practical realisation of a prototype of the LC FF optics implemented in the ATF2 facility at KEK, Japan, presently being commissioned and operated.

  11. Integrated proteomic and metabolic analysis of breast cancer progression.

    Directory of Open Access Journals (Sweden)

    Patrick G Shaw

    Full Text Available One of the most persistent hallmarks of cancer biology is the preference of tumor cells to derive energy through glycolysis as opposed to the more efficient process of oxidative phosphorylation (OXPHOS. However, little is known about the molecular cascades by which oncogenic pathways bring about this metabolic switch. We carried out a quantitative proteomic and metabolic analysis of the MCF10A derived cell line model of breast cancer progression that includes parental cells and derivatives representing three different tumor grades of Ras-driven cancer with a common genetic background. A SILAC (Stable Isotope Labeling by Amino acids in Cell culture labeling strategy was used to quantify protein expression in conjunction with subcellular fractionation to measure dynamic subcellular localization in the nucleus, cytosol and mitochondria. Protein expression and localization across cell lines were compared to cellular metabolic rates as a measure of oxidative phosphorylation (OXPHOS, glycolysis and cellular ATP. Investigation of the metabolic capacity of the four cell lines revealed that cellular OXPHOS decreased with breast cancer progression independently of mitochondrial copy number or electron transport chain protein expression. Furthermore, glycolytic lactate secretion did not increase in accordance with cancer progression and decreasing OXPHOS capacity. However, the relative expression and subcellular enrichment of enzymes critical to lactate and pyruvate metabolism supported the observed extracellular acidification profiles. This analysis of metabolic dysfunction in cancer progression integrated with global protein expression and subcellular localization is a novel and useful technique for determining organelle-specific roles of proteins in disease.

  12. Analysis Methods for Progressive Damage of Composite Structures

    Science.gov (United States)

    Rose, Cheryl A.; Davila, Carlos G.; Leone, Frank A.

    2013-01-01

    This document provides an overview of recent accomplishments and lessons learned in the development of general progressive damage analysis methods for predicting the residual strength and life of composite structures. These developments are described within their State-of-the-Art (SoA) context and the associated technology barriers. The emphasis of the authors is on developing these analysis tools for application at the structural level. Hence, modeling of damage progression is undertaken at the mesoscale, where the plies of a laminate are represented as a homogenous orthotropic continuum. The aim of the present effort is establish the ranges of validity of available models, to identify technology barriers, and to establish the foundations of the future investigation efforts. Such are the necessary steps towards accurate and robust simulations that can replace some of the expensive and time-consuming "building block" tests that are currently required for the design and certification of aerospace structures.

  13. Status of the KLOE Electromagnetic Calorimeter: final optimization, progress in construction and first calibration

    International Nuclear Information System (INIS)

    Antonelli, M.; Anulli, F.; Barbiellini, G.; Bertolucci, S.; Bini, C.; Bloise, C.; Caloi, R.; Cabibbo, G.; Campana, P.; Cervelli, F.; De Zorzi, G.; Di Cosimo, G.; Di Domenico, A.; Erriquez, O.; Di Falco, S.; Farilla, A.; Ferrari, A.; Franzini, P.; Gauzzi, P.; Giovannella, S.; Graziani, E.; Han, S.W.; Incagli, M.; Kim, W.; Lanfranchi, G.; Lee-Franzini, J.; Lomtadze, T.; Miscetti, S.; Murtas, F.; Scuri, F.; Spiriti, E.; Tortora, L.; Venanzoni, G.; Woelfle, S.; Zhang, J.Q.

    1997-01-01

    The design and the status of construction of the KLOE electromagnetic calorimeter are described in this report. 18 out of 24 barrel modules have been fully assembled and more than 50% of the end-cap modules are built. All experimental specifications are fulfilled as shown by the test beam results of the final size prototype. Since the quality of fibers and photomultipliers have gone through improvements, the final calorimeter performances will exceed our expectations. The main parameters of each calorimeter module (light yield, attenuation length and time resolution) are fully surveyed using cosmic rays. Extrapolating the results to electromagnetic showers, a time resolution of 55 ps/√(E(GeV)) and a resolution of 0.9 cm/√(E(GeV)) on the coordinate along the fibers are obtained. An energy resolution of 4.7%/√(E(GeV)) can also be quoted. (orig.)

  14. Experimental Program Final Technical Progress Report: 15 February 2007 to 30 September 2012

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, Edward R. [University of Colorado, Boulder, CO

    2014-09-12

    This is the final technical report of the grant DE-FG02-04ER41301 to the University of Colorado at Boulder entitled "Intermediate Energy Nuclear Physics" and describes the results of our funded activities during the period 15 February 2007 to 30 September 2012. These activities were primarily carried out at Fermilab, RHIC, and the German lab DESY. Significant advances in these experiments were carried out by members of the Colorado group and are described in detail.

  15. Gene expression analysis of relapsing– remitting, primary progressive and secondary progressive multiple sclerosis

    DEFF Research Database (Denmark)

    Ratzer, R; Søndergaard, Helle Bach; Christensen, Jeppe Romme

    2013-01-01

    Previous studies of multiple sclerosis (MS) have indicated differences in the pathogenesis in relapsing-remitting (RRMS), secondary progressive (SPMS) and primary progressive (PPMS) disease.......Previous studies of multiple sclerosis (MS) have indicated differences in the pathogenesis in relapsing-remitting (RRMS), secondary progressive (SPMS) and primary progressive (PPMS) disease....

  16. [Clinical comparative analysis for pulmonary histoplasmosis and progressive disseminated histoplasmosis].

    Science.gov (United States)

    Zhang, Yan; Su, Xiaoli; Li, Yuanyuan; He, Ruoxi; Hu, Chengping; Pan, Pinhua

    2016-12-28

    To compare clinical features, diagnosis and therapeutic effect between pulmonary histoplasmosis and progressive disseminated histoplasmosis.
 Methods: A retrospective analysis for 12 cases of hospitalized patients with histoplasmosis, who was admitted in Xiangya Hospital, Central South University during the time from February 2009 to October 2015, was carried out. Four cases of pulmonary histoplasmosis and 8 cases of progressive disseminated histoplasmosis were included. The differences of clinical features, imaging tests, means for diagnosis and prognosis were analyzed between the two types of histoplasmosis.
 Results: The clinical manifestations of pulmonary histoplasmosis were mild, such as dry cough. However, the main clinical symptoms of progressive disseminated histoplasmosis were severe, including recurrence of high fever, superficial lymph node enlargement over the whole body, hepatosplenomegaly, accompanied by cough, abdominal pain, joint pain, skin changes, etc.Laboratory examination showed pancytopenia, abnormal liver function and abnormal coagulation function. One pulmonary case received the operation of left lower lung lobectomy, 3 cases of pulmonary histoplasmosis and 6 cases of progressive disseminated histoplasmosis patients were given deoxycholate amphotericin B, itraconazole, voriconazole or fluconazole for antifungal therapy. One disseminated case discharged from the hospital without treatment after diagnosis of histoplasmosis, and 1 disseminated case combined with severe pneumonia and active tuberculosis died ultimately.
 Conclusion: As a rare fungal infection, histoplasmosis is easily to be misdiagnosed. The diagnostic criteria depends on etiology through bone marrow smear and tissues biopsy. Liposomeal amphotericin B, deoxycholate amphotericin B and itraconazole are recommended to treat infection for histoplasma capsulatum.

  17. [Tampa Electric Company IGCC project]. Final public design report; Technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This final Public Design Report (PDR) provides completed design information about Tampa Electric Company`s Polk Power Station Unit No. 1, which will demonstrate in a commercial 250 MW unit the operating parameters and benefits of the integration of oxygen-blown, entrained-flow coal gasification with advanced combined cycle technology. Pending development of technically and commercially viable sorbent for the Hot Gas Cleanup System, the HGCU also is demonstrated. The report is organized under the following sections: design basis description; plant descriptions; plant systems; project costs and schedule; heat and material balances; general arrangement drawings; equipment list; and miscellaneous drawings.

  18. Medium-energy nuclear physics research. Final technical progress report, May 1, 1971-November 30, 1981

    International Nuclear Information System (INIS)

    Willard, H.B.

    1981-01-01

    Final results are summarized for this program with the primary emphasis on measurement of ten independent parameters for proton-proton elastic scattering at 800 MeV and four independent such parameters at 650 MeV. Inelastic proton-proton reactions have also been measured at 800 MeV. Proton-deuteron elastic scattering cross sections and polarization analyzing powers have been obtained at 800 MeV. Proton-nucleus total and total reaction cross sections were measured at 700 MeV for a number of nuclei. Major instrumentation was designed and constructed to carry out this program

  19. [Research progresses of anabolic steroids analysis in doping control].

    Science.gov (United States)

    Long, Yuanyuan; Wang, Dingzhong; Li, Ke'an; Liu, Feng

    2008-07-01

    Anabolic steroids, a kind of physiological active substance, are widely abused to improve athletic performance in human sports. They have been forbidden in sports by the International Olympic Committee since 1983. Since then, many researchers have been focusing their attentions on the establishment of reliable detection methods. In this paper, we review the research progresses of different analytical methods for anabolic steroids since 2002, such as gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, immunoassay, electrochemistry analysis and mass spectrometry. The developing prospect of anabolic steroids analysis is also discussed.

  20. Detection of progression of glaucomatous retinal nerve fibre layer defects using optical coherence tomography-guided progression analysis.

    Science.gov (United States)

    Hwang, Young Hoon; Kim, Min Kyung; Wi, Jae Min; Chung, Jae Keun; Lee, Kwan Bok

    2018-01-01

    The aim was to investigate the agreement for detection of progression of glaucomatous retinal nerve fibre layer defects (RNFLD) between optical coherence tomography-guided progression analysis (OCT GPA) and conventional red-free fundus photography. Four hundred and fifteen glaucomatous eyes that underwent at least four serial red-free photographic and OCT examinations were included in the study. Based on the inspection of the red-free fundus photographs and GPA maps, RNFLD progression was defined as the development of a new defect, widening or deepening of a pre-existing RNFLD in red-free fundus photography (photographic progression) or 'Likely Loss' on a GPA map (GPA progression). The agreement of photographic and OCT GPA progression and the factors influencing it, including refractive error, severity of glaucoma (mean deviation of the visual field), type of RNFLD (localised versus diffuse), width of the baseline RNFLD, type of RNFLD progression (new defect, widening, deepening) and location of RNFLD progression (clock-hour sector) were assessed. Among the 415 eyes, 82 (19.8 per cent) showed photographic or GPA progression. Among the 82 eyes with progression, progression was detected only in red-free fundus photography in nine (11.0 per cent) eyes and only in GPA in 32 (39.0 per cent) eyes. In 41 eyes (50.0 per cent), progression was detected with both methods. Detection of RNFLD progression only in GPA was associated with a higher myopia, diffuse RNFLD, deepening of the RNFLD and RNFLD progression at the 6, 9 and 12 o'clock positions (p < 0.05). OCT GPA may be a useful supplement to conventional red-free fundus photography for detecting RNFLD progression. © 2017 Optometry Australia.

  1. Development of a Coal Quality Expert. Final technical progress report No. 9

    Energy Technology Data Exchange (ETDEWEB)

    1992-09-08

    This is the ninth Technical Progress Report, describing work performed under DOE Contract No. (DE-FC2290PC896631) ``Development of a Coal Quality Expert.`` The contract is a Cooperative Agreement between the US Department of Energy, CQ Inc., and ABB Combustion Engineering, Inc. This report covers the period from April 1, through June 30, 1992. Four companies and seven host utilities have teamed with CQ Inc. and ABB/CE to perform the work on this project. The work falls under DOE`s Clean Coal Technology Program category of ``Advanced Coal Cleaning.`` The 45-month project will provide the utility industry with a PC expert system to confidently and inexpensively evaluate the potential for coal cleaning blending, and switching options to reduce emissions while producing lowest cost electricity. Specifically, this project will: (1) Enhance the existing Coal Quality Information System (CQIS) database and. Coal Quality Impact Model (CQIM) to allow confident assessment of the effects of cleaning on specific boiler cost and performance. (2) Develop and validate a methodology, Coal Quality Expert (CQE) which allows accurate and detailed predictions of coal quality impacts on total power plant capital cost, operating cost, and performance based upon inputs from inexpensive bench-scale tests.

  2. Fusion reactor systems studies. Progress report for the period November 1, 1996--October 31, 1997, and final report

    International Nuclear Information System (INIS)

    El-Guebaly, L.A.; Blanchard, J.P.; Kulcinski, G.L.

    1997-08-01

    During FY97, the University of Wisconsin Fusion Technology Institute personnel have participated in the ARIES-RS and the ARIES-ST projects. The main areas of effort are: (1) neutronics analysis; (2) shielding of components and personnel; (3) neutron wall loading distribution; (4) radiation damage to in-vessel components; (5) components lifetimes; (6) embrittled materials designs issues; (7) stress and structural analysis; (8) activation, LOCA, and safety analysis; (9) support and fabrication of components; (10) vacuum system; and (11) maintenance. Progress made in these areas are summarized

  3. Theoretical studies in nuclear structure. Final progress report, June 1, 1991--July 31, 1996

    International Nuclear Information System (INIS)

    Marshalek, E.R.

    1997-01-01

    The general purview of the project is the theory of collective motion in atomic nuclei. The chief aim is to elucidate the phenomena of (1) anharmonic multiphonon excitations, and (2) collective tilted rotation, both of which are topics of considerable current interest. In the primary stage of an investigation it is often necessary to develop appropriate mathematical tools, as was the case here. In the next stage, the formalism must be tested on simple soluble models. The work described here is mainly concerned with these two stages. The final stage of realistic applications will require more time, manpower and, of course, the necessary funding. Some planning for this last stage has been carried out and anticipated problems axe briefly discussed. As it turns out, both of the above topics can be approached within the unified framework of a theorem that I developed, called the Cranking Bifurcation Theorem (CBT) to be described below. The CBT can be regarded as an outgrowth of the boson expansion method, which provides a general, and, in principal, exact formalism for treating collective excitations. We begin with a brief discussion of the CBT and then continue on to the applications

  4. Probabilistic Accident Progression Analysis with application to a LMFBR design

    International Nuclear Information System (INIS)

    Jamali, K.M.

    1982-01-01

    A method for probabilistic analysis of accident sequences in nuclear power plant systems referred to as ''Probabilistic Accident Progression Analysis'' (PAPA) is described. Distinctive features of PAPA include: (1) definition and analysis of initiator-dependent accident sequences on the component level; (2) a new fault-tree simplification technique; (3) a new technique for assessment of the effect of uncertainties in the failure probabilities in the probabilistic ranking of accident sequences; (4) techniques for quantification of dependent failures of similar components, including an iterative technique for high-population components. The methodology is applied to the Shutdown Heat Removal System (SHRS) of the Clinch River Breeder Reactor Plant during its short-term (0 -2 . Major contributors to this probability are the initiators loss of main feedwater system, loss of offsite power, and normal shutdown

  5. Coal plasticity at high heating rates and temperatures. Final technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    Gerjarusak, S.; Peters, W.A.; Howard, J.B.

    1995-05-01

    Plastic coals are important feedstocks in coke manufacture, coal liquefaction, gasification, and combustion. During these processes, the thermoplastic behavior of these coals is also important since it may contribute to desirable or undesirable characteristics. For example, during liquefaction, the plastic behavior is desired since it leads to liquid-liquid reactions which are faster than solid-liquid reactions. During gasification, the elastic behavior is undesired since it leads to caking and agglomeration of coal particles which result in bed bogging in fixed or fluidized bed gasifiers. The plastic behavior of different coals was studied using a fast-response plastometer. A modified plastometer was used to measure the torque required to turn at constant angular speed a cone-shaped disk embedded in a thin layer of coal. The coal particles were packed between two metal plates which are heated electrically. Heating rates, final temperatures, pressures, and durations of experiment ranged from 200--800 K/s, 700--1300 K, vacuum-50 atm helium, and 0--40 s, respectively. The apparent viscosity of the molten coal was calculated from the measured torque using the governing equation of the cone-and-plate viscometer. Using a concentrated suspension model, the molten coal`s apparent viscosity was related to the quantity of the liquid metaplast present during pyrolysis. Seven coals from Argonne National Laboratory Premium Coal Sample Bank were studied. Five bituminous coals, from high-volatile to low-volatile bituminous, were found to have very good plastic behavior. Coal type strongly affects the magnitude and duration of plasticity. Hvb coals were most plastic. Mvb and lvb coals, though the maximum plasticity and plastic period were less. Low rank coals such as subbituminous and lignite did not exhibit any plasticity in the present studies. Coal plasticity is moderately well correlated with simple indices of coal type such as the elemental C,O, and H contents.

  6. Technical basis for the ITER final design report, cost review and safety analysis (FDR)

    International Nuclear Information System (INIS)

    1998-01-01

    The ITER final design report, cost review and safety analysis (FDR) is the 4th major milestone, representing the progress made in the ITER Engineering Design Activities. With the approval of the Detailed Design Report (DDR), the design work was concentrated on the requirements of operation, with only relatively minor changes to design concepts of major components. The FDR is the culmination of almost 6 years collaborative design and supporting technical work by the ITER Joint Central Team and Home Teams under the terms of the ITER EDA Agreement

  7. Final Technical Progress Report Long term risk from actinides in the environment: Modes of mobility

    International Nuclear Information System (INIS)

    Kirchner, Thomas B.

    2002-01-01

    in diameter and approximately 22 cm long. A thin ''marker layer'' of white soil was added to the top of each column followed by a thin layer of soil that had been spiked with 137Cs, cerium and lanthanum was applied to the surface. Approximately 900 cm of water (the equivalent of about 30 years of rainfall) was then applied at a rate of 3.2 L d-1. All of the activity contained in the soil core appeared to be in the top few mm of soil, i.e. there was virtually no movement of the 134Cs labeled particles. Finally, a library of object-oriented model components was created using Visual Basic to support the construction of contaminant transport models. These components greatly simplify the task of building 1- to 3- dimensional simulation models for risk assessment. The model components created under this funding were subsequently applied to help answer questions regarding risks from irrigation associated with potential releases from the Yucca Mountain waste repository

  8. Final Technical Progress Report Long term risk from actinides in the environment: Modes of mobility

    Energy Technology Data Exchange (ETDEWEB)

    Thomas B. Kirchner

    2002-03-22

    in diameter and approximately 22 cm long. A thin ''marker layer'' of white soil was added to the top of each column followed by a thin layer of soil that had been spiked with 137Cs, cerium and lanthanum was applied to the surface. Approximately 900 cm of water (the equivalent of about 30 years of rainfall) was then applied at a rate of 3.2 L d-1. All of the activity contained in the soil core appeared to be in the top few mm of soil, i.e. there was virtually no movement of the 134Cs labeled particles. Finally, a library of object-oriented model components was created using Visual Basic to support the construction of contaminant transport models. These components greatly simplify the task of building 1- to 3- dimensional simulation models for risk assessment. The model components created under this funding were subsequently applied to help answer questions regarding risks from irrigation associated with potential releases from the Yucca Mountain waste repository.

  9. Novel catalysts for upgrading coal-derived liquids. Final technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, L.T.; Savage, P.E.; Briggs, D.E.

    1995-03-31

    Research described in this report was aimed at synthesizing and evaluating supported Mo oxynitrides and oxycarbides for the selective removal of nitrogen, sulfur and oxygen from model and authentic coal-derived liquids. The Al{sub 2}O{sub 3}-supported oxynitrides and oxycarbides were synthesized via the temperature programmed reaction of supported molybdenum oxides or hydrogen bronzes with NH{sub 3} or an equimolar mixture of CH{sub 4} and H{sub 2}. Phase constituents and composition were determined by X-ray diffraction, CHN analysis, and neutron activation analysis. Oxygen chemisorption was used to probe the surface structure of the catalysts. The reaction rate data was collected using specially designed micro-batch reactors. The Al{sub 2}O{sub 3}-supported Mo oxynitrides and oxycarbides were competitively active for quinoline hydrodenitrogenation (HDN), benzothiophene hydrodesulfurization (HDS) and benzofuran hydrodeoxygenation (HDO). In fact, the HDN and HDO specific reaction rates for several of the oxynitrides and oxycarbides were higher than those of a commercial Ni-Mo/Al{sub 2}O{sub 3} hydrotreatment catalyst. Furthermore, the product distributions indicated that the oxynitrides and oxycarbides were more hydrogen efficient than the sulfide catalysts. For HDN and HDS the catalytic activity was a strong inverse function of the Mo loading. In contrast, the benzofuran hydrodeoxygenation (HDO) activities did not appear to be affected by the Mo loading but were affected by the heating rate employed during nitridation or carburization. This observation suggested that HDN and HDS occurred on the same active sites while HDO was catalyzed by a different type of site.

  10. PROGRESSIVE COLLAPSE ANALYSIS OF 2-D RC FRAMES USING AEM

    Directory of Open Access Journals (Sweden)

    Osama El-Mahdy

    2017-12-01

    Full Text Available Numerical simulation of a progressive collapse of structures using computer has a very actual apprehension for structural engineers due to their interest in structures veracity estimation. This simulation helps engineers to develop methods for increasing or decreasing the progressive failure. Finite Element Method (FEM is the most computer simulation analysis currently used to perform a structural vulnerability assessment. Unfortunately, FEM is not able to automatically analyze a structure after element separation and collision which has a great effect on a structure’s performance during collapse. For instances, a bombing load can cause damage to a main supporting column in a structure, which will cause debris flying at a very high velocity from the damaged column. This debris can cause another local failure in another column upon impact and lead to the progressive collapse of the whole structure. A new simulation technique, which was developed in 1995 as part of Tagel-Din’s doctoral research, called Applied Element Method (AEM can simulate the structure’s behaviour from zero loading until collapse, through the elastic phase, opening and propagation of cracks, yielding of reinforcement bars and separation and collision of elements. This method is used in Extreme Loading for Structures software (ELS by Applied Science International (ASI. In the current paper, a brief description of the AEM is given. Also, numerical modelling based on two experimental studies available in the literature conducted by Ahmadi et al. and Yi et al. are generated using ELS. These models are used to confirm the capability of AEM in simulation the progressive collapse behaviour of structures. Also, the models are utilized to examine and measure the structural resisting mechanisms of reinforced concrete structures against progressive collapse. The obtained numerical results indicated that, ELS can accurately model all structural behaviour stages up to collapse. A

  11. Final analysis of the ALS lattice magnet data

    International Nuclear Information System (INIS)

    Keller, R.

    1993-05-01

    A preliminary analysis of the measured magnet data of the multipole magnets to be installed in the Advanced Light Source (ALS) storage ring had been given in the last conference of this series. That analysis was based on measurements of about one-third of the entire magnet complement, and some of its findings had to be revised after obtaining more data. The present paper gives an account of the integrated fundamental field strengths of all installed storage ring lattice magnets. For the multipole magnets, these values are listed as analytical expressions with four or five parameters, that cover the entire excitation range and include residual strength. Based on this final analysis, all gradient and quadrupole magnets were qualified for installation, whereas the sextupole magnets had to be individually trimmed to bring their effective fundamental strengths into the desired tolerance band

  12. Fuel Storage Facility Final Safety Analysis Report. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Linderoth, C.E.

    1984-03-01

    The Fuel Storage Facility (FSF) is an integral part of the Fast Flux Test Facility. Its purpose is to provide long-term storage (20-year design life) for spent fuel core elements used to provide the fast flux environment in FFTF, and for test fuel pins, components and subassemblies that have been irradiated in the fast flux environment. This Final Safety Analysis Report (FSAR) and its supporting documentation provides a complete description and safety evaluation of the site, the plant design, operations, and potential accidents.

  13. Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression.

    Science.gov (United States)

    Fiziev, Petko; Akdemir, Kadir C; Miller, John P; Keung, Emily Z; Samant, Neha S; Sharma, Sneha; Natale, Christopher A; Terranova, Christopher J; Maitituoheti, Mayinuer; Amin, Samirkumar B; Martinez-Ledesma, Emmanuel; Dhamdhere, Mayura; Axelrad, Jacob B; Shah, Amiksha; Cheng, Christine S; Mahadeshwar, Harshad; Seth, Sahil; Barton, Michelle C; Protopopov, Alexei; Tsai, Kenneth Y; Davies, Michael A; Garcia, Benjamin A; Amit, Ido; Chin, Lynda; Ernst, Jason; Rai, Kunal

    2017-04-25

    The extent and nature of epigenomic changes associated with melanoma progression is poorly understood. Through systematic epigenomic profiling of 35 epigenetic modifications and transcriptomic analysis, we define chromatin state changes associated with melanomagenesis by using a cell phenotypic model of non-tumorigenic and tumorigenic states. Computation of specific chromatin state transitions showed loss of histone acetylations and H3K4me2/3 on regulatory regions proximal to specific cancer-regulatory genes in important melanoma-driving cell signaling pathways. Importantly, such acetylation changes were also observed between benign nevi and malignant melanoma human tissues. Intriguingly, only a small fraction of chromatin state transitions correlated with expected changes in gene expression patterns. Restoration of acetylation levels on deacetylated loci by histone deacetylase (HDAC) inhibitors selectively blocked excessive proliferation in tumorigenic cells and human melanoma cells, suggesting functional roles of observed chromatin state transitions in driving hyperproliferative phenotype. Through these results, we define functionally relevant chromatin states associated with melanoma progression. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  14. Adhesive Characterization and Progressive Damage Analysis of Bonded Composite Joints

    Science.gov (United States)

    Girolamo, Donato; Davila, Carlos G.; Leone, Frank A.; Lin, Shih-Yung

    2014-01-01

    The results of an experimental/numerical campaign aimed to develop progressive damage analysis (PDA) tools for predicting the strength of a composite bonded joint under tensile loads are presented. The PDA is based on continuum damage mechanics (CDM) to account for intralaminar damage, and cohesive laws to account for interlaminar and adhesive damage. The adhesive response is characterized using standard fracture specimens and digital image correlation (DIC). The displacement fields measured by DIC are used to calculate the J-integrals, from which the associated cohesive laws of the structural adhesive can be derived. A finite element model of a sandwich conventional splice joint (CSJ) under tensile loads was developed. The simulations indicate that the model is capable of predicting the interactions of damage modes that lead to the failure of the joint.

  15. Final progress report

    International Nuclear Information System (INIS)

    Blann, M.

    1978-01-01

    A summary is given of the main contributions made under the subject contract. A list of publications resulting therefrom, conference addresses, and contributed papers is appended. Titles of Ph.D. theses, M.S. theses, and the names of students doing the work are also summarized

  16. Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Kotov, Valeri [Univ. of Vermont, Burlington, VT (United States)

    2016-05-29

    The research in this program involves theoretical investigations of electronic, optical and mechanical properties of graphene and its derivatives, such as bi-layer graphene, graphene-based van der Waals heterostructures, strained graphene, as well as graphene on various surfaces. One line of research has been development of theoretical models that support graphene’s large array of possible technological applications. For example one of our goals has been the understanding of surface plasmons and spin relaxation mechanisms in graphene, related to novel optoelectronics and spintronics applications. Our current research focus is on understanding the role of correlations in graphene under mechanical deformations, such as strain. The main goal is to describe the mutual interplay between strain and electron-electron interactions which could lead to the formation of novel elec- tronic phases with strongly modified electronic, magnetic and optical properties. This direction of research contributes to deeper understanding of interactions in graphene and related atomically-thin materials - a subject at the forefront of research on graphene and its derivatives.

  17. Final Technical Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    J.Y. Hwang; R.C. Greenlund

    2002-12-31

    Michigan Technological University has demonstrated major inroads in establishing the viability of utilizing aluminum smelting by-product waste materials in lightweight concrete product applications. The research identified key elements of producing various forms of lightweight concrete products through utilizing various procedures and mixture components with the by-product materials. A process was developed through pilot plant testing that results in additional aluminum recovery at finer sizes, a clean returnable salt product through spray drying technology, and a low-salt-content oxide product with enough aluminum metal content that it can be used to form lightweight cementitious mixtures. Having three distinct products aids in generating favorable process economics. Revenue projections from aluminum recovery and salt recovery are enough to cover processing costs and create a cost-free oxide product to market for lightweight concrete applications. This supply side commercialization strategy offers aluminum by-product recyclers a potentially no cost product, which has been demonstrated through this project to create desirable and marketable lightweight concrete products of various forms. Environmental benefits to the public are tremendous. At best, all dross and salt cake materials have the potential to be completely recycled and utilized. At worst, disposal sites would see a reduced amount of material: a post processed oxide product with little salt and no hydrogen sulfide or ammonia gas generating capability, which, if isolated from high alkali conditions, would pose no reactivity concerns. The US aluminum industry has historically, along with the steel industry, been a leader in recycling metal. The findings from this project, increased metal recovery, improved salt recycling, and demonstrated end uses for oxide residues, will go a long way in helping the aluminum industry obtain 100% material utilization and zero discharge.

  18. Final Safety Analysis Report (FSAR) for Building 332, Increment III

    Energy Technology Data Exchange (ETDEWEB)

    Odell, B. N.; Toy, Jr., A. J.

    1977-08-31

    This Final Safety Analysis Report (FSAR) supplements the Preliminary Safety Analysis Report (PSAR), dated January 18, 1974, for Building 332, Increment III of the Plutonium Materials Engineering Facility located at the Lawrence Livermore Laboratory (LLL). The FSAR, in conjunction with the PSAR, shows that the completed increment provides facilities for safely conducting the operations as described. These documents satisfy the requirements of ERDA Manual Appendix 6101, Annex C, dated April 8, 1971. The format and content of this FSAR complies with the basic requirements of the letter of request from ERDA San to LLL, dated March 10, 1972. Included as appendices in support of th FSAR are the Building 332 Operational Safety Procedure and the LLL Disaster Control Plan.

  19. Progressive Damage and Failure Analysis of Composite Laminates

    Science.gov (United States)

    Joseph, Ashith P. K.

    Composite materials are widely used in various industries for making structural parts due to higher strength to weight ratio, better fatigue life, corrosion resistance and material property tailorability. To fully exploit the capability of composites, it is required to know the load carrying capacity of the parts made of them. Unlike metals, composites are orthotropic in nature and fails in a complex manner under various loading conditions which makes it a hard problem to analyze. Lack of reliable and efficient failure analysis tools for composites have led industries to rely more on coupon and component level testing to estimate the design space. Due to the complex failure mechanisms, composite materials require a very large number of coupon level tests to fully characterize the behavior. This makes the entire testing process very time consuming and costly. The alternative is to use virtual testing tools which can predict the complex failure mechanisms accurately. This reduces the cost only to it's associated computational expenses making significant savings. Some of the most desired features in a virtual testing tool are - (1) Accurate representation of failure mechanism: Failure progression predicted by the virtual tool must be same as those observed in experiments. A tool has to be assessed based on the mechanisms it can capture. (2) Computational efficiency: The greatest advantages of a virtual tools are the savings in time and money and hence computational efficiency is one of the most needed features. (3) Applicability to a wide range of problems: Structural parts are subjected to a variety of loading conditions including static, dynamic and fatigue conditions. A good virtual testing tool should be able to make good predictions for all these different loading conditions. The aim of this PhD thesis is to develop a computational tool which can model the progressive failure of composite laminates under different quasi-static loading conditions. The analysis

  20. Aquatic Toxic Analysis by Monitoring Fish Behavior Using Computer Vision: A Recent Progress

    Directory of Open Access Journals (Sweden)

    Chunlei Xia

    2018-01-01

    Full Text Available Video tracking based biological early warning system achieved a great progress with advanced computer vision and machine learning methods. Ability of video tracking of multiple biological organisms has been largely improved in recent years. Video based behavioral monitoring has become a common tool for acquiring quantified behavioral data for aquatic risk assessment. Investigation of behavioral responses under chemical and environmental stress has been boosted by rapidly developed machine learning and artificial intelligence. In this paper, we introduce the fundamental of video tracking and present the pioneer works in precise tracking of a group of individuals in 2D and 3D space. Technical and practical issues suffered in video tracking are explained. Subsequently, the toxic analysis based on fish behavioral data is summarized. Frequently used computational methods and machine learning are explained with their applications in aquatic toxicity detection and abnormal pattern analysis. Finally, advantages of recent developed deep learning approach in toxic prediction are presented.

  1. Urban Integrated Industrial Cogeneration Systems Analysis. Phase II final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    Through the Urban Integrated Industrial Cogeneration Systems Analysis (UIICSA), the City of Chicago embarked upon an ambitious effort to identify the measure the overall industrial cogeneration market in the city and to evaluate in detail the most promising market opportunities. This report discusses the background of the work completed during Phase II of the UIICSA and presents the results of economic feasibility studies conducted for three potential cogeneration sites in Chicago. Phase II focused on the feasibility of cogeneration at the three most promising sites: the Stockyards and Calumet industrial areas, and the Ford City commercial/industrial complex. Each feasibility case study considered the energy load requirements of the existing facilities at the site and the potential for attracting and serving new growth in the area. Alternative fuels and technologies, and ownership and financing options were also incorporated into the case studies. Finally, site specific considerations such as development incentives, zoning and building code restrictions and environmental requirements were investigated.

  2. Using of BEPU methodology in a final safety analysis report

    International Nuclear Information System (INIS)

    Menzel, Francine; Sabundjian, Gaiane; D'auria, Francesco; Madeira, Alzira A.

    2015-01-01

    The Nuclear Reactor Safety (NRS) has been established since the discovery of nuclear fission, and the occurrence of accidents in Nuclear Power Plants worldwide has contributed for its improvement. The Final Safety Analysis Report (FSAR) must contain complete information concerning safety of the plant and plant site, and must be seen as a compendium of NRS. The FSAR integrates both the licensing requirements and the analytical techniques. The analytical techniques can be applied by using a realistic approach, addressing the uncertainties of the results. This work aims to show an overview of the main analytical techniques that can be applied with a Best Estimated Plus Uncertainty (BEPU) methodology, which is 'the best one can do', as well as the ALARA (As Low As Reasonably Achievable) principle. Moreover, the paper intends to demonstrate the background of the licensing process through the main licensing requirements. (author)

  3. Using of BEPU methodology in a final safety analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, Francine; Sabundjian, Gaiane, E-mail: fmenzel@ipen.br, E-mail: gdjian@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); D' auria, Francesco, E-mail: f.dauria@ing.unipi.it [Universita degli Studi di Pisa, Gruppo di Ricerca Nucleare San Piero a Grado (GRNSPG), Pisa (Italy); Madeira, Alzira A., E-mail: alzira@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    The Nuclear Reactor Safety (NRS) has been established since the discovery of nuclear fission, and the occurrence of accidents in Nuclear Power Plants worldwide has contributed for its improvement. The Final Safety Analysis Report (FSAR) must contain complete information concerning safety of the plant and plant site, and must be seen as a compendium of NRS. The FSAR integrates both the licensing requirements and the analytical techniques. The analytical techniques can be applied by using a realistic approach, addressing the uncertainties of the results. This work aims to show an overview of the main analytical techniques that can be applied with a Best Estimated Plus Uncertainty (BEPU) methodology, which is 'the best one can do', as well as the ALARA (As Low As Reasonably Achievable) principle. Moreover, the paper intends to demonstrate the background of the licensing process through the main licensing requirements. (author)

  4. Analysis of sea water by difference chromatography. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Mangelsdorf, P.C. Jr.

    1977-02-01

    During the final period of this research contract the principal results obtained were: (a) the development of anion analysis by difference chromatography to the extent that SO/sub 4//sup =//Cl/sup -/ can be determined to better than 0.1 percent using an 0.5 ml seawater sample, (b) the determination of the ion-exchange cation complements of a variety of sediments in river water and in seawater, and (c) the discovery of a simple technique for the qualitative removal of NH/sub 4//sup +/ from seawater samples without altering the ratios of the other cations. This method supersedes the use of Cu-Chelex which has proved impossible to sustain.

  5. Diffusion tensor analysis of corpus callosum in progressive supranuclear palsy

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Shoichi; Makino, Takahiro; Shirai, Wakako; Hattori, Takamichi [Department of Neurology, Graduate School of Medicine, Chiba University (Japan)

    2008-11-15

    Progressive supranuclear palsy (PSP) is a neurodegenerative disease featuring parkinsonism, supranuclear ophthalmoplegia, dysphagia, and frontal lobe dysfunction. The corpus callosum which consists of many commissure fibers probably reflects cerebral cortical function. Several previous reports showed atrophy or diffusion abnormalities of anterior corpus callosum in PSP patients, but partitioning method used in these studies was based on data obtained in nonhuman primates. In this study, we performed a diffusion tensor analysis using a new partitioning method for the human corpus callosum. Seven consecutive patients with PSP were compared with 29 age-matched patients with Parkinson's Disease (PD) and 19 age-matched healthy control subjects. All subjects underwent diffusion tensor magnetic resonance imaging, and the corpus callosum was partitioned into five areas on the mid-sagittal plane according to a recently established topography of human corpus callosum (CC1-prefrontal area, CC2-premotor and supplementary motor area, CC3-motor area, CC4-sensory area, CC5-parietal, temporal, and occipital area). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in each area and differences between groups were analyzed. In the PSP group, FA values were significantly decreased in CC1 and CC2, and ADC values were significantly increased in CC1 and CC2. Receiver operating characteristic analysis showed excellent reliability of FA and ADC analyses of CC1 for differentiating PSP from PD. The anterior corpus callosum corresponding to the prefrontal, premotor, and supplementary motor cortices is affected in PSP patients. This analysis can be an additional test for further confirmation of the diagnosis of PSP.

  6. Diffusion tensor analysis of corpus callosum in progressive supranuclear palsy

    International Nuclear Information System (INIS)

    Ito, Shoichi; Makino, Takahiro; Shirai, Wakako; Hattori, Takamichi

    2008-01-01

    Progressive supranuclear palsy (PSP) is a neurodegenerative disease featuring parkinsonism, supranuclear ophthalmoplegia, dysphagia, and frontal lobe dysfunction. The corpus callosum which consists of many commissure fibers probably reflects cerebral cortical function. Several previous reports showed atrophy or diffusion abnormalities of anterior corpus callosum in PSP patients, but partitioning method used in these studies was based on data obtained in nonhuman primates. In this study, we performed a diffusion tensor analysis using a new partitioning method for the human corpus callosum. Seven consecutive patients with PSP were compared with 29 age-matched patients with Parkinson's Disease (PD) and 19 age-matched healthy control subjects. All subjects underwent diffusion tensor magnetic resonance imaging, and the corpus callosum was partitioned into five areas on the mid-sagittal plane according to a recently established topography of human corpus callosum (CC1-prefrontal area, CC2-premotor and supplementary motor area, CC3-motor area, CC4-sensory area, CC5-parietal, temporal, and occipital area). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in each area and differences between groups were analyzed. In the PSP group, FA values were significantly decreased in CC1 and CC2, and ADC values were significantly increased in CC1 and CC2. Receiver operating characteristic analysis showed excellent reliability of FA and ADC analyses of CC1 for differentiating PSP from PD. The anterior corpus callosum corresponding to the prefrontal, premotor, and supplementary motor cortices is affected in PSP patients. This analysis can be an additional test for further confirmation of the diagnosis of PSP

  7. A Portfolio Analysis Tool for Measuring NASAs Aeronautics Research Progress toward Planned Strategic Outcomes

    Science.gov (United States)

    Tahmasebi, Farhad; Pearce, Robert

    2016-01-01

    Description of a tool for portfolio analysis of NASA's Aeronautics research progress toward planned community strategic Outcomes is presented. The strategic planning process for determining the community Outcomes is also briefly described. Stakeholder buy-in, partnership performance, progress of supporting Technical Challenges, and enablement forecast are used as the criteria for evaluating progress toward Outcomes. A few illustrative examples are also presented.

  8. 10 CFR 52.157 - Contents of applications; technical information in final safety analysis report.

    Science.gov (United States)

    2010-01-01

    ...; technical information in final safety analysis report. The application must contain a final safety analysis... 10 Energy 2 2010-01-01 2010-01-01 false Contents of applications; technical information in final safety analysis report. 52.157 Section 52.157 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES...

  9. Progress on retinal image analysis for age related macular degeneration.

    Science.gov (United States)

    Kanagasingam, Yogesan; Bhuiyan, Alauddin; Abràmoff, Michael D; Smith, R Theodore; Goldschmidt, Leonard; Wong, Tien Y

    2014-01-01

    Age-related macular degeneration (AMD) is the leading cause of vision loss in those over the age of 50 years in the developed countries. The number is expected to increase by ∼1.5 fold over the next ten years due to an increase in aging population. One of the main measures of AMD severity is the analysis of drusen, pigmentary abnormalities, geographic atrophy (GA) and choroidal neovascularization (CNV) from imaging based on color fundus photograph, optical coherence tomography (OCT) and other imaging modalities. Each of these imaging modalities has strengths and weaknesses for extracting individual AMD pathology and different imaging techniques are used in combination for capturing and/or quantification of different pathologies. Current dry AMD treatments cannot cure or reverse vision loss. However, the Age-Related Eye Disease Study (AREDS) showed that specific anti-oxidant vitamin supplementation reduces the risk of progression from intermediate stages (defined as the presence of either many medium-sized drusen or one or more large drusen) to late AMD which allows for preventative strategies in properly identified patients. Thus identification of people with early stage AMD is important to design and implement preventative strategies for late AMD, and determine their cost-effectiveness. A mass screening facility with teleophthalmology or telemedicine in combination with computer-aided analysis for large rural-based communities may identify more individuals suitable for early stage AMD prevention. In this review, we discuss different imaging modalities that are currently being considered or used for screening AMD. In addition, we look into various automated and semi-automated computer-aided grading systems and related retinal image analysis techniques for drusen, geographic atrophy and choroidal neovascularization detection and/or quantification for measurement of AMD severity using these imaging modalities. We also review the existing telemedicine studies which

  10. Analysis of Member State RED implementation. Final Report (Task 2)

    Energy Technology Data Exchange (ETDEWEB)

    Peters, D.; Alberici, S.; Toop, G. [Ecofys, Utrecht (Netherlands); Kretschmer, B. [Institute for European Environmental Policy IEEP, London (United Kingdom)

    2012-12-15

    This report describes the way EU Member States have transposed the sustainability and chain of custody requirements for biofuels as laid down in the Renewable Energy Directive (RED) and Fuel Quality Directive (FQD). In the assessment of Member States' implementation, the report mainly focuses on effectiveness and administrative burden. Have Member States transposed the Directives in such a way that compliance with the sustainability criteria can be ensured as effectively as possible? To what extent does the Member States' implementation lead to unnecessary administrative burden for economic operators in the (bio)fuel supply chain? The report focuses specifically on the transposition of the sustainability and chain of custody requirements, not on the target for renewables on transport. This means that for example the double counting provision is not included as part of the scope of this report. This report starts with an introduction covering the implementation of the Renewable Energy (and Fuel Quality) Directive into national legislation, the methodology by which Member States were assessed against effectiveness and administrative burden and the categorisation of Member State's national systems for RED-implementation (Chapter 1). The report continues with a high level description of each Member State system assessed (Chapter 2). Following this, the report includes analysis of the Member States on the effectiveness and administrative burden of a number of key ('major') measures (Chapter 3). The final chapter presents the conclusions and recommendations (Chapter 4)

  11. Deashing of coal liquids with ceramic membrane microfiltration and diafiltration. Final quarterly technical progress report, October 1--December 31, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    Diafiltration experiments were done to determine how much particulate- free oil could be extracted from the solids-containing stream. The 0. 05 {mu}m titania membrane was used for the concentration/diafiltration process runs at 270 C, 80 psig inlet pressure, and 6 gpm crossflow. Five concentration process runs were conducted. After the initial run, the concentrated material was diluted with hydrotreated start-up oil from the final solids back to 10% solids. The concentration was limited by increased pressure drop with increased solids content and plugged membrane module channels. Solids retention was greater than 99.5% for all samples. Attempts to clean membranes with solvent failed due to lack of time. Samples of the permeate and concentrate streams were taken for analysis; the diluent had a similar bp range to the coal liquids in the atmospheric bottoms; thus, distillation could not be used to separate the bottoms from the diluent.

  12. Assessment of Intralaminar Progressive Damage and Failure Analysis Using an Efficient Evaluation Framework

    Science.gov (United States)

    Hyder, Imran; Schaefer, Joseph; Justusson, Brian; Wanthal, Steve; Leone, Frank; Rose, Cheryl

    2017-01-01

    Reducing the timeline for development and certification for composite structures has been a long standing objective of the aerospace industry. This timeline can be further exacerbated when attempting to integrate new fiber-reinforced composite materials due to the large number of testing required at every level of design. computational progressive damage and failure analysis (PDFA) attempts to mitigate this effect; however, new PDFA methods have been slow to be adopted in industry since material model evaluation techniques have not been fully defined. This study presents an efficient evaluation framework which uses a piecewise verification and validation (V&V) approach for PDFA methods. Specifically, the framework is applied to evaluate PDFA research codes within the context of intralaminar damage. Methods are incrementally taken through various V&V exercises specifically tailored to study PDFA intralaminar damage modeling capability. Finally, methods are evaluated against a defined set of success criteria to highlight successes and limitations.

  13. [Geothermal system temperature-depth database and model for data analysis]. 5. quarterly technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    Blackwell, D.D.

    1998-04-25

    During this first quarter of the second year of the contract activity has involved several different tasks. The author has continued to work on three tasks most intensively during this quarter: the task of implementing the data base for geothermal system temperature-depth, the maintenance of the WWW site with the heat flow and gradient data base, and finally the development of a modeling capability for analysis of the geothermal system exploration data. The author has completed the task of developing a data base template for geothermal system temperature-depth data that can be used in conjunction with the regional data base that he had already developed and is now implementing it. Progress is described.

  14. Measurement and apportionment of radon source terms for modeling indoor environments. Final progress report, March 1990--August 1992

    Energy Technology Data Exchange (ETDEWEB)

    Harley, N.H.

    1992-12-31

    During the present 2 1/2 year contract period, we have made significant Progress in modeling the source apportionment of indoor {sup 222}Rn and in {sup 222}Rn decay product dosimetry. Two additional areas were worked on which we believe are useful for the DOE Radon research Program. One involved an analysis of the research house data, grouping the hourly house {sup 222}Rn measurements into 2 day, 7 day and 90 day intervals to simulate the response of passive monitors. Another area requiring some attention resulted in a publication of 3 years of our indoor/outdoor measurements in a high-rise apartment. Little interest has been evinced in apartment measurements yet 20% of the US population lives in multiple-family dwellings, not in contact with the ground. These data together with a summary of all other published data on apartments showed that apartments have only about 50% greater {sup 222}Rn concentration than the measured outdoor {sup 222}Rn. Apartment dwellers generally represent a low risk group regarding {sup 222}Rn exposure. The following sections describe the main projects in some detail.

  15. Glaucomatous progression in the retinal nerve fibre and retinal ganglion cell-inner plexiform layers determined using optical coherence tomography-guided progression analysis.

    Science.gov (United States)

    Hwang, Young Hoon; Kim, Yeji; Chung, Jae Keun; Lee, Kwan Bok

    2018-02-01

    To investigate the characteristics of glaucomatous progression in circumpapillary retinal nerve fibre layer (RNFL) and macular retinal ganglion cell-inner plexiform layer (GCIPL) determined using optical coherence tomography-guided progression analysis (OCT-GPA). Serial OCT images of 527 glaucomatous eyes with greater than four OCT tests were screened. Among them, 106 (20.1 per cent) eyes with progression in either RNFL or GCIPL determined using OCT-GPA were included. Based on the agreement of progression detection between RNFL and GCIPL, the eyes were classified into the 'RNFL progression earlier group', 'GCIPL progression earlier group', or 'simultaneous progression group'. The type of progression was classified as diffuse, localised or mixed. Among the 106 eyes with progression, 100 (94.3 per cent) showed RNFL progression and 83 (78.3 per cent) showed GCIPL progression. Fifty-four (50.9 per cent), 13 (12.3 per cent), and 39 (36.8 per cent) eyes were classified into the RNFL progression earlier group, GCIPL progression earlier group, and simultaneous progression group, respectively. Diffuse-type progression was found in three (three per cent) eyes with RNFL progression and 32 (38.6 per cent) eyes with GCIPL progression. The most common location of progression was the 7 o'clock sector (42.0 per cent) in the RNFL and the inferotemporal sector (39.8 per cent) in the GCIPL. The most common characteristic of RNFL and GCIPL progression determined using OCT-GPA was localised thinning in the inferotemporal area. Progression was more frequently found in the RNFL than in the GCIPL, and diffuse-type progression was more frequent in the GCIPL than in the RNFL. © 2018 Optometry Australia.

  16. Analysis of molecular changes during human melanocytic tumor progression.

    NARCIS (Netherlands)

    Wit, N.J. de

    2005-01-01

    Melanoma is one of the most aggressive types of cancer, due to its potency to disseminate early in tumor progression. The incidence is still rising, even though the rate of change has leveled off in the last decade. As melanoma cells are relatively insensitive to classical systemic therapies, like

  17. Progressive failure analysis of fibrous composite materials and structures

    Science.gov (United States)

    Bahei-El-din, Yehia A.

    1990-01-01

    A brief description is given of the modifications implemented in the PAFAC finite element program for the simulation of progressive failure in fibrous composite materials and structures. Details of the memory allocation, input data, and the new subroutines are given. Also, built-in failure criteria for homogeneous and fibrous composite materials are described.

  18. Enhancing metabolomic data analysis with Progressive Consensus Alignment of NMR Spectra (PCANS

    Directory of Open Access Journals (Sweden)

    O'Connell Thomas M

    2010-03-01

    Full Text Available Abstract Background Nuclear magnetic resonance spectroscopy is one of the primary tools in metabolomics analyses, where it is used to track and quantify changes in metabolite concentrations or profiles in response to perturbation through disease, toxicants or drugs. The spectra generated through such analyses are typically confounded by noise of various types, obscuring the signals and hindering downstream statistical analysis. Such issues are becoming increasingly significant as greater numbers of large-scale systems or longitudinal studies are being performed, in which many spectra from different conditions need to be compared simultaneously. Results We describe a novel approach, termed Progressive Consensus Alignment of Nmr Spectra (PCANS, for the alignment of NMR spectra. Through the progressive integration of many pairwise comparisons, this approach generates a single consensus spectrum as an output that is then used to adjust the chemical shift positions of the peaks from the original input spectra to their final aligned positions. We characterize the performance of PCANS by aligning simulated NMR spectra, which have been provided with user-defined amounts of chemical shift variation as well as inter-group differences as would be observed in control-treatment applications. Moreover, we demonstrate how our method provides better performance than either template-based alignment or binning. Finally, we further evaluate this approach in the alignment of real mouse urine spectra and demonstrate its ability to improve downstream PCA and PLS analyses. Conclusions By avoiding the use of a template or reference spectrum, PCANS allows for the creation of a consensus spectrum that enhances the signals within the spectra while maintaining sample-specific features. This approach is of greatest benefit when complex samples are being analyzed and where it is expected that there will be spectral features unique and/or strongly different between subgroups

  19. Analysis Of The Tank 6F Final Characterization Samples-2012

    Energy Technology Data Exchange (ETDEWEB)

    Oji, L. N.; Diprete, D. P.; Coleman, C. J.; Hay, M. S.; Shine, E. P.

    2012-09-27

    The Savannah River National Laboratory (SRNL) was requested by Savannah River Remediation (SRR) to provide sample preparation and analysis of the Tank 6F final characterization samples to determine the residual tank inventory prior to grouting. Fourteen residual Tank 6F solid samples from three areas on the floor of the tank were collected and delivered to SRNL between May and August 2011. These Tank 6F samples were homogenized and combined into three composite samples based on a proportion compositing scheme and the resulting composite samples were analyzed for radiological, chemical and elemental components. Additional measurements performed on the Tank 6F composite samples include bulk density and water leaching of the solids to account for water soluble components. The composite Tank 6F samples were analyzed and the data reported in triplicate. Sufficient quality assurance standards and blanks were utilized to demonstrate adequate characterization of the Tank 6F samples. The main evaluation criteria were target detection limits specified in the technical task request document. While many of the target detection limits were met for the species characterized for Tank 6F some were not met. In a few cases, the relatively high levels of radioactive species of the same element or a chemically similar element precluded the ability to measure some isotopes to low levels. The isotopes whose detection limits were not met in all cases included Sn-126, Sb-126, Sb-126m, Eu-152, Cm-243 and Cf-249. SRNL, in conjunction with the customer, reviewed all of these cases and determined that the impacts of not meeting the target detection limits were acceptable. Based on the analyses of variance (ANOVA) for the inorganic constituents of Tank 6F, all the inorganic constituents displayed heterogeneity. The inorganic results demonstrated consistent differences across the composite samples: lowest concentrations for Composite Sample 1, intermediate-valued concentrations for Composite

  20. Analysis of the Tank 6F Final Characterization Samples-2012

    Energy Technology Data Exchange (ETDEWEB)

    Oji, L. N.; Diprete, D. P.; Coleman, C. J.; Hay, M. S.; Shine, E. P.

    2013-01-31

    The Savannah River National Laboratory (SRNL) was requested by Savannah River Remediation (SRR) to provide sample preparation and analysis of the Tank 6F final characterization samples to determine the residual tank inventory prior to grouting. Fourteen residual Tank 6F solid samples from three areas on the floor of the tank were collected and delivered to SRNL between May and August 2011. These Tank 6F samples were homogenized and combined into three composite samples based on a proportion compositing scheme and the resulting composite samples were analyzed for radiological, chemical and elemental components. Additional measurements performed on the Tank 6F composite samples include bulk density and water leaching of the solids to account for water soluble components. The composite Tank 6F samples were analyzed and the data reported in triplicate. Sufficient quality assurance standards and blanks were utilized to demonstrate adequate characterization of the Tank 6F samples. The main evaluation criteria were target detection limits specified in the technical task request document. While many of the target detection limits were met for the species characterized for Tank 6F some were not met. In a few cases, the relatively high levels of radioactive species of the same element or a chemically similar element precluded the ability to measure some isotopes to low levels. The isotopes whose detection limits were not met in all cases included Sn-126, Sb-126, Sb-126m, Eu-152, Cm- 243 and Cf-249. SRNL, in conjunction with the customer, reviewed all of these cases and determined that the impacts of not meeting the target detection limits were acceptable. Based on the analyses of variance (ANOVA) for the inorganic constituents of Tank 6F, all the inorganic constituents displayed heterogeneity. The inorganic results demonstrated consistent differences across the composite samples: lowest concentrations for Composite Sample 1, intermediate-valued concentrations for Composite

  1. ANALYSIS OF THE TANK 5F FINAL CHARATERIZATION SAMPLES-2011

    Energy Technology Data Exchange (ETDEWEB)

    Oji, L.; Diprete, D.; Coleman, C.; Hay, M.

    2012-01-20

    The Savannah River National Laboratory (SRNL) was requested by SRR to provide sample preparation and analysis of the Tank 5F final characterization samples to determine the residual tank inventory prior to grouting. Two types of samples were collected and delivered to SRNL: floor samples across the tank and subsurface samples from mounds near risers 1 and 5 of Tank 5F. These samples were taken from Tank 5F between January and March 2011. These samples from individual locations in the tank (nine floor samples and six mound Tank 5F samples) were each homogenized and combined in a given proportion into 3 distinct composite samples to mimic the average composition in the entire tank. These Tank 5F composite samples were analyzed for radiological, chemical and elemental components. Additional measurements performed on the Tank 5F composite samples include bulk density and water leaching of the solids to account for water soluble species. With analyses for certain challenging radionuclides as the exception, all composite Tank 5F samples were analyzed and reported in triplicate. The target detection limits for isotopes analyzed were based on customer desired detection limits as specified in the technical task request documents. SRNL developed new methodologies to meet these target detection limits and provide data for the extensive suite of components. While many of the target detection limits were met for the species characterized for Tank 5F, as specified in the technical task request, some were not met. In a few cases, the relatively high levels of radioactive species of the same element or a chemically similar element precluded the ability to measure some isotopes to low levels. The Technical Task Request allows that while the analyses of these isotopes is needed, meeting the detection limits for these isotopes is a lower priority than meeting detection limits for the other specified isotopes. The isotopes whose detection limits were not met in all cases included the

  2. Analysis Of The Tank 5F Final Characterization Samples-2011

    Energy Technology Data Exchange (ETDEWEB)

    Oji, L. N.; Diprete, D.; Coleman, C. J.; Hay, M. S.

    2012-09-27

    The Savannah River National Laboratory (SRNL) was requested by SRR to provide sample preparation and analysis of the Tank 5F final characterization samples to determine the residual tank inventory prior to grouting. Two types of samples were collected and delivered to SRNL: floor samples across the tank and subsurface samples from mounds near risers 1 and 5 of Tank 5F. These samples were taken from Tank 5F between January and March 2011. These samples from individual locations in the tank (nine floor samples and six mound Tank 5F samples) were each homogenized and combined in a given proportion into 3 distinct composite samples to mimic the average composition in the entire tank. These Tank 5F composite samples were analyzed for radiological, chemical and elemental components. Additional measurements performed on the Tank 5F composite samples include bulk density and water leaching of the solids to account for water soluble species. With analyses for certain challenging radionuclides as the exception, all composite Tank 5F samples were analyzed and reported in triplicate. The target detection limits for isotopes analyzed were based on customer desired detection limits as specified in the technical task request documents. SRNL developed new methodologies to meet these target detection limits and provide data for the extensive suite of components. While many of the target detection limits were met for the species characterized for Tank 5F, as specified in the technical task request, some were not met. In a few cases, the relatively high levels of radioactive species of the same element or a chemically similar element precluded the ability to measure some isotopes to low levels. The Technical Task Request allows that while the analyses of these isotopes is needed, meeting the detection limits for these isotopes is a lower priority than meeting detection limits for the other specified isotopes. The isotopes whose detection limits were not met in all cases included the

  3. ANALYSIS OF THE TANK 5F FINAL CHARACTERIZATION SAMPLES-2011

    Energy Technology Data Exchange (ETDEWEB)

    Oji, L.; Diprete, D.; Coleman, C.; Hay, M.

    2012-08-03

    The Savannah River National Laboratory (SRNL) was requested by SRR to provide sample preparation and analysis of the Tank 5F final characterization samples to determine the residual tank inventory prior to grouting. Two types of samples were collected and delivered to SRNL: floor samples across the tank and subsurface samples from mounds near risers 1 and 5 of Tank 5F. These samples were taken from Tank 5F between January and March 2011. These samples from individual locations in the tank (nine floor samples and six mound Tank 5F samples) were each homogenized and combined in a given proportion into 3 distinct composite samples to mimic the average composition in the entire tank. These Tank 5F composite samples were analyzed for radiological, chemical and elemental components. Additional measurements performed on the Tank 5F composite samples include bulk density and water leaching of the solids to account for water soluble species. With analyses for certain challenging radionuclides as the exception, all composite Tank 5F samples were analyzed and reported in triplicate. The target detection limits for isotopes analyzed were based on customer desired detection limits as specified in the technical task request documents. SRNL developed new methodologies to meet these target detection limits and provide data for the extensive suite of components. While many of the target detection limits were met for the species characterized for Tank 5F, as specified in the technical task request, some were not met. In a few cases, the relatively high levels of radioactive species of the same element or a chemically similar element precluded the ability to measure some isotopes to low levels. The Technical Task Request allows that while the analyses of these isotopes is needed, meeting the detection limits for these isotopes is a lower priority than meeting detection limits for the other specified isotopes. The isotopes whose detection limits were not met in all cases included the

  4. ANALYSIS OF THE TANK 6F FINAL CHARACTERIZATION SAMPLES-2012

    Energy Technology Data Exchange (ETDEWEB)

    Oji, L.; Diprete, D.; Coleman, C.; Hay, M.; Shine, G.

    2012-06-28

    The Savannah River National Laboratory (SRNL) was requested by Savannah River Remediation (SRR) to provide sample preparation and analysis of the Tank 6F final characterization samples to determine the residual tank inventory prior to grouting. Fourteen residual Tank 6F solid samples from three areas on the floor of the tank were collected and delivered to SRNL between May and August 2011. These Tank 6F samples were homogenized and combined into three composite samples based on a proportion compositing scheme and the resulting composite samples were analyzed for radiological, chemical and elemental components. Additional measurements performed on the Tank 6F composite samples include bulk density and water leaching of the solids to account for water soluble components. The composite Tank 6F samples were analyzed and the data reported in triplicate. Sufficient quality assurance standards and blanks were utilized to demonstrate adequate characterization of the Tank 6F samples. The main evaluation criteria were target detection limits specified in the technical task request document. While many of the target detection limits were met for the species characterized for Tank 6F some were not met. In a few cases, the relatively high levels of radioactive species of the same element or a chemically similar element precluded the ability to measure some isotopes to low levels. The isotopes whose detection limits were not met in all cases included Sn-126, Sb-126, Sb-126m, Eu-152, Cm-243 and Cf-249. SRNL, in conjunction with the customer, reviewed all of these cases and determined that the impacts of not meeting the target detection limits were acceptable. Based on the analyses of variance (ANOVA) for the inorganic constituents of Tank 6F, all the inorganic constituents displayed heterogeneity. The inorganic results demonstrated consistent differences across the composite samples: lowest concentrations for Composite Sample 1, intermediate-valued concentrations for Composite

  5. Thermodynamic Activity-Based Progress Curve Analysis in Enzyme Kinetics.

    Science.gov (United States)

    Pleiss, Jürgen

    2018-03-01

    Macrokinetic Michaelis-Menten models based on thermodynamic activity provide insights into enzyme kinetics because they separate substrate-enzyme from substrate-solvent interactions. Kinetic parameters are estimated from experimental progress curves of enzyme-catalyzed reactions. Three pitfalls are discussed: deviations between thermodynamic and concentration-based models, product effects on the substrate activity coefficient, and product inhibition. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Analysis of interventional therapy for progressing stage gastric cancer

    International Nuclear Information System (INIS)

    Zhu Mingde; Zhang Zijing; Ji Hongsheng; Ge Chenlin; Hao Gang; Wei Kongming; Yuan Yuhou; Zhao Xiuping

    2008-01-01

    Objective: To investigate the interventional therapy and its curative effect for progressing stage gastric cancer. Methods: two hundred and twelve patients with progressing stage gastric cancer were treated with arterial perfusion and arterial embolization. Gastric cardia cancer was treated through the left gastric artery and the left inferior phrenic artery or splenic artery. Cancers of lesser and greater gastric curvature was treated either through the left and right gastric arteries or common hepatic artery or through gastroduodenal artery, right gastroomental artery or splenic artery. Gastric antrum cancers were perfused through gastroduodenal artery or after the middle segmental embolization of right gastroomental artery. Results: One hundred and ninety three cases undergone interventional management were followed up. The CR + PR of gastric cardia cancer was 53.13%; gastric body cancer 44.44%; gastric antrum cancer 10%; recurrent cancer and remnant gastric cancer 0. There was no significant difference in outcome between gastric cardia cancer and gastric body cancer (P>0.05) but significant differences were shown both between gastric cardia cancer and gastric antrum cancer, and between gastric body cancer and gastric antrum cancer (P<0.05), with 1 year and 2 years survival rates of 81% and 56% respectively. Conclusion: The interventional therapeutic effect of progressing stage gastric cancers is different due to the different sites of the lesions in the gastric tissue. The curative effect of gastric cardia cancer and gastric body cancer is better than that of gastric antrum cancer, recurrent cancer and remnant gastric cancer. (authors)

  7. Reactive Collisions and Final State Analysis in Hypersonic Flight Regime

    Science.gov (United States)

    2016-09-13

    Rotational excitation Figure 21 reports the final state distribution P (j′′) for N+2 from sim - ulations on the bare and ZPE-corrected PES starting from...D.; Wilkinson, A. IUPAC. Compendium of Chemical Terminology, 2nd ed. (the Gold Book); Blackwell Scientific Publications, Oxford, 1997. [19] Valli, G

  8. The oncogenic action of ionizing radiation on rat skin. Final progress report, May 1, 1990--April 30, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Burns, F.J.; Garte, S.J.

    1992-12-31

    The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/{mu}), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of {sup 14}C-thymidine. The return of these cells to S-phase a second time was detected by a second label ({sup 3}H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The {sup 14}C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with {sup 14}C increased after 42 hr and remained relatively constant thereafter.

  9. Final Technical Progress Report; Closeout Certifications; CSSV Newsletter Volume I; CSSV Newsletter Volume II; CSSV Activity Journal; CSSV Final Financial Report

    Energy Technology Data Exchange (ETDEWEB)

    Houston, Johnny L [PI; Geter, Kerry [Division of Business and Finance

    2013-08-23

    This Project?s third year of implementation in 2007-2008, the final year, as designated by Elizabeth City State University (ECSU), in cooperation with the National Association of Mathematicians (NAM) Inc., in an effort to promote research and research training programs in computational science ? scientific visualization (CSSV). A major goal of the Project was to attract the energetic and productive faculty, graduate and upper division undergraduate students of diverse ethnicities to a program that investigates science and computational science issues of long-term interest to the Department of Energy (DoE) and the nation. The breadth and depth of computational science?scientific visualization and the magnitude of resources available are enormous for permitting a variety of research activities. ECSU?s Computational Science-Science Visualization Center will serve as a conduit for directing users to these enormous resources.

  10. Progress in the NNPDF global analysis and the impact of the legacy HERA combination

    NARCIS (Netherlands)

    Rojo, Juan

    2015-01-01

    The H1 and ZEUS collaborations have recently presented their final results for the combination of inclusive cross-section measurements taken during Run I and Run II at the HERA collider. In this contribution, following an overview of recent progress in the NNPDF framework, we quantify the impact of

  11. In silico regulatory analysis for exploring human disease progression

    Directory of Open Access Journals (Sweden)

    DeLisi Charles

    2008-06-01

    Full Text Available Abstract Background An important goal in bioinformatics is to unravel the network of transcription factors (TFs and their targets. This is important in the human genome, where many TFs are involved in disease progression. Here, classification methods are applied to identify new targets for 152 transcriptional regulators using publicly-available targets as training examples. Three types of sequence information are used: composition, conservation, and overrepresentation. Results Starting with 8817 TF-target interactions we predict an additional 9333 targets for 152 TFs. Randomized classifiers make few predictions (~2/18660 indicating that our predictions for many TFs are significantly enriched for true targets. An enrichment score is calculated and used to filter new predictions. Two case-studies for the TFs OCT4 and WT1 illustrate the usefulness of our predictions: • Many predicted OCT4 targets fall into the Wnt-pathway. This is consistent with known biology as OCT4 is developmentally related and Wnt pathway plays a role in early development. • Beginning with 15 known targets, 354 predictions are made for WT1. WT1 has a role in formation of Wilms' tumor. Chromosomal regions previously implicated in Wilms' tumor by cytological evidence are statistically enriched in predicted WT1 targets. These findings may shed light on Wilms' tumor progression, suggesting that the tumor progresses either by loss of WT1 or by loss of regions harbouring its targets. • Targets of WT1 are statistically enriched for cancer related functions including metastasis and apoptosis. Among new targets are BAX and PDE4B, which may help mediate the established anti-apoptotic effects of WT1. • Of the thirteen TFs found which co-regulate genes with WT1 (p ≤ 0.02, 8 have been previously implicated in cancer. The regulatory-network for WT1 targets in genomic regions relevant to Wilms' tumor is provided. Conclusion We have assembled a set of features for the targets of

  12. Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives.

    Science.gov (United States)

    Ashley, Jon; Shahbazi, Mohammad-Ali; Kant, Krishna; Chidambara, Vinayaka Aaydha; Wolff, Anders; Bang, Dang Duong; Sun, Yi

    2017-05-15

    Molecularly imprinted polymers (MIPs) are biomimetics which can selectively bind to analytes of interest. One of the most interesting areas where MIPs have shown the biggest potential is food analysis. MIPs have found use as sorbents in sample preparation attributed to the high selectivity and high loading capacity. MIPs have been intensively employed in classical solid-phase extraction and solid-phase microextraction. More recently, MIPs have been combined with magnetic bead extraction, which greatly simplifies sample handling procedures. Studies have consistently shown that MIPs can effectively minimize complex food matrix effects, and improve recoveries and detection limits. In addition to sample preparation, MIPs have also been viewed as promising alternatives to bio-receptors due to the inherent molecular recognition abilities and the high stability in harsh chemical and physical conditions. MIPs have been utilized as receptors in biosensing platforms such as electrochemical, optical and mass biosensors to detect various analytes in food. In this review, we will discuss the current state-of-the-art of MIP synthesis and applications in the context of food analysis. We will highlight the imprinting methods which are applicable for imprinting food templates, summarize the recent progress in using MIPs for preparing and analysing food samples, and discuss the current limitations in the commercialisation of MIPs technology. Finally, future perspectives will be given. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Neutron activation analysis of final molasses from cuban sugar industry

    International Nuclear Information System (INIS)

    Griffith, J.; Gonzalez, E.; Rosenberg, R.J.; Diaz-Rizo, O.

    1996-01-01

    Thermal and epithermal non-destructive activation analyses have been performed on samples of final molasses from 14 different sugar factories , covering the most important regions in Cuba. From the first measurement after irradiation at the Triga Mark reactor (VTT), the concentration of more than 15 elements is reported. The almost constant elemental composition shows that they can be used equally for different purposes as animal foodstuff and for the manufacture of biotechnological products. This work is part of a research project developed in order to establish a complete characterization of Cuban sugar molasses. (author). 7 refs., 2 tabs

  14. Total RNA Sequencing Analysis of DCIS Progressing to Invasive Breast Cancer

    Science.gov (United States)

    2015-09-01

    Assay Kits respectively on the Qubit 2.0 Fluorometer (Life Technologies). The BioRad Experion Automated Electrophoresis System RNA kit was used to...AWARD NUMBER: W81XWH-14-1-0080 TITLE: Total RNA Sequencing Analysis of DCIS Progressing to Invasive Breast Cancer. PRINCIPAL INVESTIGATOR...Aug 2015 4. TITLE AND SUBTITLE Total RNA Sequencing Analysis of DCIS Progressing to Invasive Breast Cancer. 5a. CONTRACT NUMBER 5b. GRANT

  15. 50 CFR 424.19 - Final rules-impact analysis of critical habitat.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Final rules-impact analysis of critical... LISTING ENDANGERED AND THREATENED SPECIES AND DESIGNATING CRITICAL HABITAT Revision of the Lists § 424.19 Final rules—impact analysis of critical habitat. The Secretary shall identify any significant activities...

  16. Final design and progress of WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope

    NARCIS (Netherlands)

    Dalton, Gavin; Trager, Scott; Abrams, Don Carlos; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; Middleton, Kevin; Benn, Chris; Dee, Kevin; Sayède, Frédéric; Lewis, Ian; Pragt, Johannes; Pico, Sergio; Walton, Nic; Rey, Jeurg; Allende Prieto, Carlos; Peñate, José; Lhome, Emilie; Agócs, Tibor; Alonso, José; Terrett, David; Brock, Matthew; Gilbert, James; Schallig, Ellen; Ridings, Andy; Guinouard, Isabelle; Verheijen, Marc; Tosh, Ian; Rogers, Kevin; Lee, Martin; Steele, Iain; Stuik, Remko; Tromp, Niels; Jaskó, Attila; Carrasco, Esperanza; Farcas, Szigfrid; Kragt, Jan; Lesman, Dirk; Kroes, Gabby; Mottram, Chris; Bates, Stuart; Rodriguez, Luis Fernando; Gribbin, Frank; Delgado, José Miguel; Herreros, José Miguel; Martin, Carlos; Cano, Diego; Navarro, Ramon; Irwin, Mike; Lewis, Jim; Gonzalez Solares, Eduardo; Murphy, David; Worley, Clare; Bassom, Richard; O'Mahoney, Neil; Bianco, Andrea; Zurita, Christina; ter Horst, Rik; Molinari, Emilio; Lodi, Marcello; Guerra, José; Martin, Adrian; Vallenari, Antonella; Salasnich, Bernardo; Baruffolo, Andrea; Jin, Shoko; Hill, Vanessa; Smith, Dan; Drew, Janet; Poggianti, Bianca; Pieri, Mat; Dominquez Palmero, Lillian; Farina, Cecilia

    2016-01-01

    We present the Final Design of the WEAVE next-generation spectroscopy facility for the William Herschel Telescope (WHT), together with a status update on the details of manufacturing, integration and the overall project schedule now that all the major fabrication contracts are in place. We also

  17. Photovoltaic venture analysis. Final report. Volume III. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Costello, D.; Posner, D.; Schiffel, D.; Doane, J.; Bishop, C.

    1978-07-01

    This appendix contains a brief summary of a detailed description of alternative future energy scenarios which provide an overall backdrop for the photovoltaic venture analysis. Also included is a summary of a photovoltaic market/demand workshop, a summary of a photovoltaic supply workshop which used cross-impact analysis, and a report on photovoltaic array and system prices in 1982 and 1986. The results of a sectorial demand analysis for photovoltaic power systems used in the residential sector (single family homes), the service, commercial, and institutional sector (schools), and in the central power sector are presented. An analysis of photovoltaics in the electric utility market is given, and a report on the industrialization of photovoltaic systems is included. A DOE information memorandum regarding ''A Strategy for a Multi-Year Procurement Initiative on Photovoltaics (ACTS No. ET-002)'' is also included. (WHK)

  18. Electric vehicle life cycle cost analysis : final research project report.

    Science.gov (United States)

    2017-02-01

    This project compared total life cycle costs of battery electric vehicles (BEV), plug-in hybrid electric vehicles (PHEV), hybrid electric vehicles (HEV), and vehicles with internal combustion engines (ICE). The analysis considered capital and operati...

  19. Development of a risk-analysis model. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-01

    This report consists of a main body, which provides a presentation of risk analysis and its general and specific application to the needs of the Office of Buildings and Community Systems of the Department of Energy; and several case studies employing the risk-analysis model developed. The highlights include a discussion of how risk analysis is currently used in the private, regulated, and public sectors and how this methodology can be employed to meet the policy-analysis needs of the Office of Buildings and Community Systems of the Department of Energy (BCS/DOE). After a review of the primary methodologies available for risk analysis, it was determined that Monte Carlo simulation techniques provide the greatest degree of visibility into uncertainty in the decision-making process. Although the data-collection requirements can be demanding, the benefits, when compared to other methods, are substantial. The data-collection problem can be significantly reduced, without sacrificing proprietary-information rights, if prior arrangements are made with RD and D contractors to provide responses to reasonable requests for base-case data. A total of three case studies were performed on BCS technologies: a gas-fired heat pump; a 1000 ton/day anaerobic digestion plant; and a district heating and cooling system. The three case studies plus the risk-analysis methodology were issued as separate reports. It is concluded that, based on the overall research of risk analysis and the case-study experience, that the risk-analysis methodology has significant potential as a policy-evaluation tool within BCS.

  20. Progress risk assessment of oral premalignant lesions with saliva miRNA analysis

    International Nuclear Information System (INIS)

    Yang, Ya; Li, Yue-xiu; Yang, Xi; Jiang, Long; Zhou, Zuo-jun; Zhu, Ya-qin

    2013-01-01

    Oral cancer develops through multi-stages: from normal to mild (low grade) dysplasia (LGD), moderate dysplasia, and severe (high grade) dysplasia (HGD), to carcinoma in situ (CIS) and finally invasive oral squamous cell carcinomas (OSCC). Clinical and histological assessments are not reliable in predicting which precursor lesions will progress. The aim of this study was to assess the potential of a noninvasive approach to assess progress risk of oral precancerous lesions. We first used microRNA microarray to profile progressing LGD oral premaligant lesions (OPLs) from non-progressing LGD OPLs in order to explore the possible microRNAs deregulated in low grade OPLs which later progressed to HGD or OSCC. We then used RT-qPCR to detect miRNA targets from the microarray results in saliva samples of these patients. We identified a specific miRNA signature that is aberrantly expressed in progressing oral LGD leukoplakias. Similar expression patterns were detected in saliva samples from these patients. These results show promise for using saliva miRNA signature for monitoring of cancer precursor lesions and early detection of disease progression

  1. Progress and challenges in the development and qualification of multi-level multi-physics coupled methodologies for reactor analysis

    International Nuclear Information System (INIS)

    Ivanov, K.; Avramova, M.

    2007-01-01

    Current trends in nuclear power generation and regulation as well as the design of next generation reactor concepts along with the continuing computer technology progress stimulate the development, qualification and application of multi-physics multi-scale coupled code systems. The efforts have been focused on extending the analysis capabilities by coupling models, which simulate different phenomena or system components, as well as on refining the scale and level of detail of the coupling. This paper reviews the progress made in this area and outlines the remaining challenges. The discussion is illustrated with examples based on neutronics/thermohydraulics coupling in the reactor core modeling. In both fields recent advances and developments are towards more physics-based high-fidelity simulations, which require implementation of improved and flexible coupling methodologies. First, the progresses in coupling of different physics codes along with the advances in multi-level techniques for coupled code simulations are discussed. Second, the issues related to the consistent qualification of coupled multi-physics and multi-scale code systems for design and safety evaluation are presented. The increased importance of uncertainty and sensitivity analysis are discussed along with approaches to propagate the uncertainty quantification between the codes. The incoming OECD LWR Uncertainty Analysis in Modeling (UAM) benchmark is the first international activity to address this issue and it is described in the paper. Finally, the remaining challenges with multi-physics coupling are outlined. (authors)

  2. Photovoltaic venture analysis. Final report. Volume II. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Costello, D.; Posner, D.; Schiffel, D.; Doane, J.; Bishop, C.

    1978-07-01

    A description of the integrating model for photovoltaic venture analysis is given; input assumptions for the model are described; and the integrating model program listing is given. The integrating model is an explicit representation of the interactions between photovoltaic markets and supply under alternative sets of assumptions. It provides a consistent way of assembling and integrating the various assumptions, data, and information that have been obtained on photovoltaic systems supply and demand factors. Secondly, it provides a mechanism for understanding the implications of all the interacting assumptions. By representing the assumptions in a common, explicit framework, much more complex interactions can be considered than are possible intuitively. The integrating model therefore provides a way of examining the relative importance of different assumptions, parameters, and inputs through sensitivity analysis. Also, detailed results of model sensitivity analysis and detailed market and systems information are presented. (WHK)

  3. Analysis of genetic copy number changes in cervical disease progression

    International Nuclear Information System (INIS)

    Policht, Frank A; Song, Minghao; Sitailo, Svetlana; O'Hare, Anna; Ashfaq, Raheela; Muller, Carolyn Y; Morrison, Larry E; King, Walter; Sokolova, Irina A

    2010-01-01

    Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which were found to have the highest frequency of aberration for use as probes in fluorescent in-situ hybridization. The frequency of gains and losses using fluorescence in-situ hybridization were assessed in these 35 regions on 30 paraffin-embedded cervical biopsy specimens. Based on this assessment, 6 candidate fluorescently labeled probes (8q24, Xp22, 20q13, 3p14, 3q26, CEP15) were selected for additional testing on a set of 106 cervical biopsy specimens diagnosed as Normal, CIN1, CIN2, CIN3, and SCC. The data were analyzed on the basis of signal mean, % change of signal mean between histological categories, and % positivity. The study revealed that the chromosomal regions with the highest frequency of copy number gains and highest combined sensitivity and specificity in high-grade cervical disease were 8q24 and 3q26. The cytological application of these two probes was then evaluated on 118 ThinPrep™ samples diagnosed as Normal, ASCUS, LSIL, HSIL and Cancer to determine utility as a tool for less invasive screening. Using gains of either 8q24 or 3q26 as a positivity criterion yielded specificity (Normal +LSIL+ASCUS) of 81.0% and sensitivity (HSIL+Cancer) of 92.3% based on a threshold of 4 positive cells. The application of a FISH assay comprised of chromosomal probes 8q24 and 3q26 to cervical cytology specimens confirms the positive correlation between increasing dysplasia and copy gains and shows promise as a marker in cervical disease progression

  4. Progress in fusion reactors blanket analysis and evaluation at CEA

    International Nuclear Information System (INIS)

    Proust, E.; Gervaise, F.; Carre, F.; Chevereau, G.; Doutriaux, D.

    1986-09-01

    In the frame of the recent CEA studies aiming at the development, evaluation and comparison of solid breeder blanket concepts in view of their adaptation to NET, the evaluation of specific questions related to the first wall design, the present paper examines first the performances of a helium cooled toroidal blanket design for NET, based on innovative Beryllium/Ceramics breeder rod elements. Neutronic and thermo-mechanical optimisation converges on a concept featured by a breeding capability in excess of 1.2, a reasonnable pumping power of 1% and a narrow breeder temperature range (470+-30 deg C of the breeder), the latter being largely independent of the power level. This design proves naturally adapted to ceramic breeder assigned to very strict working conditions, and provides for any change in the thermal and heat transfer characteristics over the blanket lifetime. The final section of the paper is devoted to the evaluation of the heat load poloidal distribution and to the irradiation effects on first wall structural materials

  5. Final Progress Report for Collaborative Research: Aging of Black Carbon during Atmospheric Transport: Understanding Results from the DOE’s 2010 CARES and 2012 ClearfLo Campaigns

    Energy Technology Data Exchange (ETDEWEB)

    Mazzoleni, Claudio [Michigan Technological Univ., Houghton, MI (United States); Subramanian, R. [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2016-08-31

    Over the course of this project, we have analyzed data and samples from the Carbonaceous Aerosol and Radiative Effects Study (CARES) and the Clear air for London (ClearfLo) campaign, as well as conducted or participated in laboratory experiments designed to better understand black carbon mixing state and climate-relevant properties. The laboratory campaigns took place at the Pacific Northwest National Laboratory and Carnegie Mellon University to study various climate-relevant aerosol properties of different sources of soot mixing with secondary organic aerosol precursors. Results from some of these activities were summarized in the previous progress report. This final report presents the manuscripts that have been published (many in the period since the last progress report), lists presentations at different conferences based on grant-related activities, and presents some results that are likely to be submitted for publication in the near future.

  6. Defect analysis program for LOFT. Progress report, 1977

    International Nuclear Information System (INIS)

    Doyle, R.E.; Scoonover, T.M.

    1978-03-01

    In order to alleviate problems encountered while performing previous defect analyses on components of the LOFT system, regions of LOFT most likely to require defect analysis have been identified. A review of available documentation has been conducted to identify shapes, sizes, materials, and welding procedures and to compile mechanical property data. The LOFT Reactor Vessel Material Surveillance Program has also been reviewed, and a survey of available literature describing existing techniques for conducting elastic-plastic defect analysis was initiated. While large amounts of mechanical property data were obtained from the available documentation and the literature, much information was not available, especially for weld heat-affected zones. Therefore, a program of mechanical property testing is recommended for FY-78 as well as continued literature search. It is also recommended that fatigue-crack growth-rate data be sought from the literature and that evaluation of the various techniques of elastic-plastic defect analysis be continued. Review of additional regions of the LOFT system in the context of potential defect analysis will be conducted as time permits

  7. Progressive-Ratio Schedules and Applied Behavior Analysis

    Science.gov (United States)

    Poling, Alan

    2010-01-01

    Establishing appropriate relations between the basic and applied areas of behavior analysis has been of long and persistent interest to the author. In this article, the author illustrates that there is a direct relation between how hard an organism will work for access to an object or activity, as indexed by the largest ratio completed under a…

  8. Fast flux test facility final safety analysis report amendment 79

    International Nuclear Information System (INIS)

    Dautel, W.A.

    1999-01-01

    This document is provided to replace, remove, or add applicable pages to the chapters on: Heat Transport System; Containment and Structures; Auxiliary Systems; Reactor Refueling System; Conduct of Operations; Safety Analysis; Quality Assurance; FFTF Criticality Specifications; and Appendix H's TRIGA Fuel Storage System

  9. Final Report: Hydrogen Production Pathways Cost Analysis (2013 – 2016)

    Energy Technology Data Exchange (ETDEWEB)

    James, Brian David [Strategic Analysis Inc., Arlington, VA (United States); DeSantis, Daniel Allan [Strategic Analysis Inc., Arlington, VA (United States); Saur, Genevieve [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-09-30

    This report summarizes work conducted under a three year Department of Energy (DOE) funded project to Strategic Analysis, Inc. (SA) to analyze multiple hydrogen (H2) production technologies and project their corresponding levelized production cost of H2. The analysis was conducted using the H2A Hydrogen Analysis Tool developed by the DOE and National Renewable Energy Laboratory (NREL). The project was led by SA but conducted in close collaboration with the NREL and Argonne National Laboratory (ANL). In-depth techno-economic analysis (TEA) of five different H2 production methods was conducted. These TEAs developed projections for capital costs, fuel/feedstock usage, energy usage, indirect capital costs, land usage, labor requirements, and other parameters, for each H2 production pathway, and use the resulting cost and system parameters as inputs into the H2A discounted cash flow model to project the production cost of H2 ($/kgH2). Five technologies were analyzed as part of the project and are summarized in this report: Proton Exchange Membrane technology (PEM), High temperature solid oxide electrolysis cell technology (SOEC), Dark fermentation of biomass for H2 production, H2 production via Monolithic Piston-Type Reactors with rapid swing reforming and regeneration reactions, and Reformer-Electrolyzer-Purifier (REP) technology developed by Fuel Cell Energy, Inc. (FCE).

  10. Progressivity, horizontal equity and reranking in health care finance: a decomposition analysis for The Netherlands.

    Science.gov (United States)

    Wagstaff, A; van Doorslaer, E

    1997-10-01

    This paper employs the method of Aronson et al. (1994) to decompose the redistributive effect of the Dutch health care financing system into three components: a progressivity component, a classical horizontal equity component and a reranking component. Results are presented for the health care financing system as a whole, as well as for its constituent parts. A final section sets out to uncover the relative importance (in terms of their effects on progressivity, horizontal equity and reranking) of the key institutional features of one component of the Dutch system-the AWBZ social insurance scheme.

  11. Scalable data management, analysis and visualization (SDAV) Institute. Final Scientific/Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Geveci, Berk [Kitware, Inc., Clifton Park, NY (United States)

    2017-03-28

    The purpose of the SDAV institute is to provide tools and expertise in scientific data management, analysis, and visualization to DOE’s application scientists. Our goal is to actively work with application teams to assist them in achieving breakthrough science, and to provide technical solutions in the data management, analysis, and visualization regimes that are broadly used by the computational science community. Over the last 5 years members of our institute worked directly with application scientists and DOE leadership-class facilities to assist them by applying the best tools and technologies at our disposal. We also enhanced our tools based on input from scientists on their needs. Many of the applications we have been working with are based on connections with scientists established in previous years. However, we contacted additional scientists though our outreach activities, as well as engaging application teams running on leading DOE computing systems. Our approach is to employ an evolutionary development and deployment process: first considering the application of existing tools, followed by the customization necessary for each particular application, and then the deployment in real frameworks and infrastructures. The institute is organized into three areas, each with area leaders, who keep track of progress, engagement of application scientists, and results. The areas are: (1) Data Management, (2) Data Analysis, and (3) Visualization. Kitware has been involved in the Visualization area. This report covers Kitware’s contributions over the last 5 years (February 2012 – February 2017). For details on the work performed by the SDAV institute as a whole, please see the SDAV final report.

  12. [Progress on Determination and Analysis of Zopiclone in Biological Samples].

    Science.gov (United States)

    Shu, C X; Gong, D; Zhang, L P; Zhao, J X

    2017-12-01

    As a new hypnotic, zopiclone is widely used in clinical treatment. There are many methods for determination of zopiclone, including spectrophotometry, chromatography and chromatography mass spectrum, etc. Present paper reviews different kinds of biological samples associated with zopiclone, extraction and purification methods, and determination and analysis methods, which aims to provide references for the relevant research and practice. Copyright© by the Editorial Department of Journal of Forensic Medicine.

  13. Recent progress on HYSPEC, and its polarization analysis capabilities

    Directory of Open Access Journals (Sweden)

    Winn Barry

    2015-01-01

    Full Text Available HYSPEC is a high-intensity, direct-geometry time-of-flight spectrometer at the Spallation Neutron Source, optimized for measurement of excitations in small single-crystal specimens with optional polarization analysis capabilities. The incident neutron beam is monochromated using a Fermi chopper with short, straight blades, and is then vertically focused by Bragg scattering onto the sample position by either a highly oriented pyrolitic graphite (unpolarized or a Heusler (polarized crystal array. Neutrons are detected by a bank of 3He tubes that can be positioned over a wide range of scattering angles about the sample axis. HYSPEC entered the user program in February 2013 for unpolarized experiments, and is already experiencing a vibrant research program. Polarization analysis will be accomplished by using the Heusler crystal array to polarize the incident beam, and either a 3He spin filter or a supermirror wide-angle polarization analyser to analyse the scattered beam. The 3He spin filter employs the spin-exchange optical pumping technique. A 60∘ wide angle 3He cell that matches the detector coverage will be used for polarization analysis. The polarized gas in the post-sample wide angle cell is designed to be periodically and automatically refreshed with an adjustable pressure of polarized gas, optically pumped in a separate cell and then transferred to the wide angle cell. The supermirror analyser has 960 supermirror polarizers distributed over 60∘, and has been characterized at the Swiss Spallation Neutron Source. The current status of the instrument and the development of its polarization analysis capabilities are presented.

  14. PROGRESS IN SIFT-MS: BREATH ANALYSIS AND OTHER APPLICATIONS

    Czech Academy of Sciences Publication Activity Database

    Španěl, Patrik; Smith, D.

    2011-01-01

    Roč. 30, č. 2 (2011), s. 236-267 ISSN 0277-7037 R&D Projects: GA MPO FT-TA4/124; GA ČR GA202/09/0800; GA ČR GA203/09/0256 Institutional research plan: CEZ:AV0Z40400503 Keywords : SIFT-MS * breath analysis * ion flow tube Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 10.461, year: 2011

  15. Final report : Occupational gap analysis, volume 2 Wood Buffalo region

    International Nuclear Information System (INIS)

    2002-06-01

    The general economy of the Wood Buffalo region of Alberta has improved in recent years due to the expansion of the oil sand industry. Many of the oil sands projects are situated in the southern part of the region and are serviced out of Lac LaBiche. This paper examines the implications of this economic growth for the regional supply and demand of workers in key occupational categories. In particular, it projects employment opportunities that are directly attributed to the regional economic expansion, and assesses whether there will be an adequate supply of workers to meet the demand for new and replacement employees. The report includes: an overview of the regional economy; a population forecast for the region and the demand for workers in selected occupations; an analysis of whether or not the new labour force entrants will choose the selected occupations; and, a supply and demand analysis. 7 tabs., 2 figs., 5 appendices

  16. Macromolecular structure analysis and effective liquefaction pretreatment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Suuberg, E.M.; Yun, Y.; Lilly, W.D.; Leung, K.; Gates, T.; Otake, Y.; Deevi, S.C.

    1994-07-01

    This project was concerned with characterizing the changes in coal macromolecular structure, that are of significance for liquefaction pretreatments of coal. The macromolecular structure of the insoluble portion of coal is difficult to characterize. Techniques that do so indirectly (based upon, for example, NMR and FTIR characterizations of atomic linkages) are not particularly sensitive for this purpose. Techniques that characterize the elastic structure (such as solvent swelling) are much more sensitive to subtle changes in the network structure. It is for this reason that we focused upon these techniques. The overall objective involved identifying pretreatments that reduce the crosslinking (physical or chemical) of the network structure, and thus lead to materials that can be handled to a greater extent by traditional liquid-phase processing techniques. These techniques tend to be inherently more efficient at producing desirable products. This report is divided into seven chapters. Chapter II summarizes the main experimental approaches used throughout the project, and summarizes the main findings on the Argonne Premium coal samples. Chapter III considers synergistic effects of solvent pairs. It is divided into two subsections. The first is concerned with mixtures of CS{sub 2} with electron donor solvents. The second subsection is concerned with aromatic hydrocarbon - alcohol or hydrocarbon - alcohol mixtures, as might be of interest for preliquefaction delivery of catalysts into bituminous coals. Chapter IV deals with questions of how oxidation might influence the results that are obtained. Chapter V briefly details what conclusions may be drawn concerning the elastic behavior of coals, and the effects of thermal treatments on this behavior. Chapter VI is concerned with theories to describe the action of solvents that are capable of dissociating non-covalent crosslinks. Finally, Chapter VII discusses the practical implications of the study.

  17. Vertically integrated analysis of human DNA. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Olson, M.

    1997-10-01

    This project has been oriented toward improving the vertical integration of the sequential steps associated with the large-scale analysis of human DNA. The central focus has been on an approach to the preparation of {open_quotes}sequence-ready{close_quotes} maps, which is referred to as multiple-complete-digest (MCD) mapping, primarily directed at cosmid clones. MCD mapping relies on simple experimental steps, supported by advanced image-analysis and map-assembly software, to produce extremely accurate restriction-site and clone-overlap maps. We believe that MCD mapping is one of the few high-resolution mapping systems that has the potential for high-level automation. Successful automation of this process would be a landmark event in genome analysis. Once other higher organisms, paving the way for cost-effective sequencing of these genomes. Critically, MCD mapping has the potential to provide built-in quality control for sequencing accuracy and to make possible a highly integrated end product even if there are large numbers of discontinuities in the actual sequence.

  18. Handbook of Basic Tables for Chemical Analysis. Final report

    International Nuclear Information System (INIS)

    Bruno, T.J.; Svoronos, P.D.N.

    1988-04-01

    This work began as a slim booklet prepared by one of the authors (TJB) to accompany a course on chemical instrumentation presented at the National Bureau of Standards, Boulder Laboratories. The booklet contained tables on chromatography, spectroscopy, and chemical (wet) methods, and was intended to provide the students with enough basic data to design their own analytical methods and procedures. Shortly thereafter, with the co-authorship of Prof. Paris D. N. Svoronos, it was expanded into a more-extensive compilation entitled Basic Tables for Chemical Analysis, published as National Bureau of Standards Technical Note 1096. That work has now been expanded and updated into the present body of tables. Although there have been considerable changes since the first version of these tables, the aim has remained essentially the same. The authors have tried to provide a single source of information for those practicing scientists and research students who must use various aspects of chemical analysis in their work. In this respect, it is geared less toward the researcher in analytical chemistry than to those practitioners in other chemical disciplines who must have routine use of chemical analysis

  19. Regulatory impact analysis of final effluent limitations guidelines and standards for the offshore oil and gas industry. Final report

    International Nuclear Information System (INIS)

    1993-01-01

    For all major rulemaking actions, Executive Order 12291 requires a Regulatory Impact Analysis (RIA), in which benefits of the regulation are compared to costs imposed by the regulation. The report presents the Environmental Protection Agency's (EPA, or the Agency) RIA of the final rule on the effluent limitations guidelines for the Offshore Subcategory of the Oil and Gas Extraction Industry. The principal requirement of the Executive Order is that the Agency perform an analysis comparing the benefits of the regulation to the costs that the regulation imposes. Three types of benefits are analyzed in this RIA: quantified and monetized benefits; quantified and non-monetized benefits; and non-quantified and non-monetized benefits

  20. Upgrade Uranium Recovery Project No. 34110: final safety analysis report

    International Nuclear Information System (INIS)

    1981-09-01

    The accident analysis of the upgrade uranium recovery system indicated three potential hazards: (1) criticality, (2) toxic fumes from nitric acid solutions, and (3) release of toxic uranyl nitrate solutions. Any of these are capable of causing the death of one or more employees; therefore, they form the basis for the residual risks identified below. The analysis found no hazardous energies or substances capable of causing irreversible injury to, or the death of, any members of the public. The following residual risks will be controlled administratively by procedural constraints: An operator or maintenance error will cause 235 U to be transferred into an unsafe container and cause a criticality. An operator or maintenance error will cause containers of 235 U bearing material to be improperly spaced and cause a criticality. Extensive corrosion will cause a hole to form in a calciner tube, the corrosion will go undetected, and a criticality will result, and a loss of system and/or building solution containment will occur concurrent with a drain being open resulting in a criticality and/or release of toxic material. Additional residual risks that have a small probability are that an earthquake or tornado will affect the building, alter the system geometry, and initiate a criticality; that the compressed-gas (nitrogen) cylinder valve will be sheared off, become airborne, and alter the system geometry; and that loss of system and/or building solution containment may occur concurrently with fire sprinkler system actuation causing a criticality and/or release of toxic material. The following residual risks will be addressed in the Safety Study of the existing X-705 Building: that a spill of raffinate highly contaminated with 99 Tc will occur due to operator error or incorrect lab analysis and that a gaseous or liquid effluent release of small amounts of transuranic elements will occur

  1. The AP600 advanced simplified nuclear power plant. Results of the test program and progress made toward final design approval

    International Nuclear Information System (INIS)

    Bruschi, H.J.

    1996-01-01

    At the 1994 Pacific Basin Conference, Mr. Bruschi presented a paper describing the AP600, Westinghouse's advanced light water reactor design with passive safety features. Since then, a rigorous test program was completed and AP600 became the most thoroughly tested advanced reactor system design in history. Westinghouse is now well on its way toward receiving Final Design Approval from the U.S. Nuclear Regulatory Commission for AP600. In this paper, the results of the test program will be discussed and an update on prospects for building the plant will be covered. (author)

  2. Final Progress Report: FRACTURE AND SUBCRITICAL DEBONDING IN THIN LAYERED STRUCTURES: EXPERIMENTS AND MULTI-SCALE MODELING

    Energy Technology Data Exchange (ETDEWEB)

    Reinhold H. Dauskardt

    2005-08-30

    Final technical report detailing unique experimental and multi-scale computational modeling capabilities developed to study fracture and subcritical cracking in thin-film structures. Our program to date at Stanford has studied the mechanisms of fracture and fatigue crack-growth in structural ceramics at high temperature, bulk and thin-film glasses in selected moist environments where we demonstrated the presence of a true mechanical fatigue effect in some glass compositions. We also reported on the effects of complex environments and fatigue loading on subcritical cracking that effects the reliability of MEMS and other micro-devices using novel micro-machined silicon specimens and nanomaterial layers.

  3. Methods of economic analysis applied to fusion research. Final report

    International Nuclear Information System (INIS)

    1983-01-01

    In this and previous efforts ECON has provided economic assessment of a fusion research program. This phase of study focused on two tasks, the first concerned with the economics of fusion in an economy that relies heavily upon synthetic fuels, and the second concerned with the overall economic effects of pursuing soft energy technologies instead of hard technologies. This report is organized in two parts, the first entitled An Economic Analysis of Coproduction of Fusion-Electric Energy and Other Products, and the second entitled Arguments Associated with the Choice of Potential Energy Futures

  4. Progress of the DUPIC Fuel Compatibility Analysis (IV) - Fuel Performance

    International Nuclear Information System (INIS)

    Choi, Hang Bok; Ryu, Ho Jin; Roh, Gyu Hong; Jeong, Chang Joon; Park, Chang Je; Song, Kee Chan; Lee, Jung Won

    2005-10-01

    This study describes the mechanical compatibility of the direct use of spent pressurized water reactor (PWR) fuel in Canada deuterium uranium (CANDU) reactors (DUPIC) fuel, when it is loaded into a CANDU reactor. The mechanical compatibility can be assessed for the fuel management, primary heat transport system, fuel channel, and the fuel handling system in the reactor core by both the experimental and analytic methods. Because the physical dimensions of the DUPIC fuel bundle adopt the CANDU flexible (CANFLEX) fuel bundle design which has already been demonstrated for a commercial use in CANDU reactors, the experimental compatibility analyses focused on the generation of material property data and the irradiation tests of the DUPIC fuel, which are used for the computational analysis. The intermediate results of the mechanical compatibility analysis have shown that the integrity of the DUPIC fuel is mostly maintained under the high power and high burnup conditions even though some material properties like the thermal conductivity is a little lower compared to the uranium fuel. However it is required to slightly change the current DUPIC fuel design to accommodate the high internal pressure of the fuel element. It is also strongly recommended to perform more irradiation tests of the DUPIC fuel to accumulate a database for the demonstration of the DUPIC fuel performance in the CANDU reactor

  5. Research on data analysis in the physical sciences. Final progress report, March 1973-November 1979

    Energy Technology Data Exchange (ETDEWEB)

    Tukey, J.W.; Bloomfield, P.

    1979-11-01

    In its most general terms, the work carried out under the contract consists of the development of new data analytic methods and the improvement of existing methods, their implementation on computer, especially minicomputers, and the development of non-statistical, systems-level software to support these activities. The work reported or completed is reviewed. (GHT)

  6. Progress on Radiochemical Analysis for Nuclear Waste Management in Decommissioning

    DEFF Research Database (Denmark)

    Hou, Xiaolin; Qiao, Jixin; Shi, Keliang

    With the increaed numbers of nuclear facilities have been closed and are being or are going to be decommissioned, it is required to characterise the produced nuclear waste for its treatment by identification of the radionuclides and qualitatively determine them. Of the radionuclides related...... separation of radionuclides. In order to improve and maintain the Nodic competence in analysis of radionculides in waste samples, a NKS B project on this topic was launched in 2009. During the first phase of the NKS-B RadWaste project (2009-2010), a good achivement has been reached on establishment...... of collaboration, identifing the requirements from the Nordic nuclear industries and optimizing and development of some analytical methods (Hou et al. NKS-222, 2010). In the year 2011, this project (NKS-B RadWaste2011) continued. The major achievements of this project in 2011 include: (1) development of a method...

  7. Research progress and hotspot analysis of spatial interpolation

    Science.gov (United States)

    Jia, Li-juan; Zheng, Xin-qi; Miao, Jin-li

    2018-02-01

    In this paper, the literatures related to spatial interpolation between 1982 and 2017, which are included in the Web of Science core database, are used as data sources, and the visualization analysis is carried out according to the co-country network, co-category network, co-citation network, keywords co-occurrence network. It is found that spatial interpolation has experienced three stages: slow development, steady development and rapid development; The cross effect between 11 clustering groups, the main convergence of spatial interpolation theory research, the practical application and case study of spatial interpolation and research on the accuracy and efficiency of spatial interpolation. Finding the optimal spatial interpolation is the frontier and hot spot of the research. Spatial interpolation research has formed a theoretical basis and research system framework, interdisciplinary strong, is widely used in various fields.

  8. Final Report. Analysis and Reduction of Complex Networks Under Uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Marzouk, Youssef M. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Coles, T. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Spantini, A. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Tosatto, L. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2013-09-30

    The project was a collaborative effort among MIT, Sandia National Laboratories (local PI Dr. Habib Najm), the University of Southern California (local PI Prof. Roger Ghanem), and The Johns Hopkins University (local PI Prof. Omar Knio, now at Duke University). Our focus was the analysis and reduction of large-scale dynamical systems emerging from networks of interacting components. Such networks underlie myriad natural and engineered systems. Examples important to DOE include chemical models of energy conversion processes, and elements of national infrastructure—e.g., electric power grids. Time scales in chemical systems span orders of magnitude, while infrastructure networks feature both local and long-distance connectivity, with associated clusters of time scales. These systems also blend continuous and discrete behavior; examples include saturation phenomena in surface chemistry and catalysis, and switching in electrical networks. Reducing size and stiffness is essential to tractable and predictive simulation of these systems. Computational singular perturbation (CSP) has been effectively used to identify and decouple dynamics at disparate time scales in chemical systems, allowing reduction of model complexity and stiffness. In realistic settings, however, model reduction must contend with uncertainties, which are often greatest in large-scale systems most in need of reduction. Uncertainty is not limited to parameters; one must also address structural uncertainties—e.g., whether a link is present in a network—and the impact of random perturbations, e.g., fluctuating loads or sources. Research under this project developed new methods for the analysis and reduction of complex multiscale networks under uncertainty, by combining computational singular perturbation (CSP) with probabilistic uncertainty quantification. CSP yields asymptotic approximations of reduceddimensionality “slow manifolds” on which a multiscale dynamical system evolves. Introducing

  9. Solar thermal repowering utility value analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, R.; Day, J.; Reed, B.; Malone, M.

    1979-12-01

    The retrofit of solar central receiver energy supply systems to existing steam-electric generating stations (repowering) is being considered as a major programmatic thrust by DOE. The determination of a government response appropriate to the opportunities of repowering is an important policy question, and is the major reason for the analysis. The study objective is to define a government role in repowering that constitutes an efficient program investment in pursuit of viable private markets for heliostat-based energy systems. In support of that objective, the study is designed to identify the scope and nature of the repowering opportunity within the larger context of its contributions to central receiver technology development and commercialization. The Supply and Integration Tasks are documented elsewhere. This report documents the Demand Task, determining and quantifying the sources of the value of repowering and of central receiver technology in general to electric utilities. The modeling tools and assumptions used in the Demand Task are described and the results are presented and interpreted. (MCW)

  10. Positron tomographic imaging of tumors using monoclonal antibodies. Final progress report, April 15, 1989--October 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, M.R.

    1997-02-01

    The overall objective of this research is to develop methods for utilizing positron emission tomography (PET) to increase the clinical potential of radiolabeled monoclonal antibodies (MAbs). Enhancement of MAb tumor localization by hyperthermia also was proposed. Studies were to have been performed with both {sup 18}F and {sup 124}I; however, the lack of its availability (until quite recently) prevented experiments with {sup 124}I. Instead, two additional lines of inquiry were initiated in which they utilized aspects of the radiofluorination chemistries originally developed for MAbs for labeling chemotactic peptides and meta-iodobenzylguanidine (MIBG) analogues with {sup 18}F. This final report summarizes the original specific aims and the main research accomplishments in studies of mouse, dog and human models.

  11. Positron tomographic imaging of tumors using monoclonal antibodies. Final progress report, April 15, 1989--October 31, 1995

    International Nuclear Information System (INIS)

    Zalutsky, M.R.

    1997-02-01

    The overall objective of this research is to develop methods for utilizing positron emission tomography (PET) to increase the clinical potential of radiolabeled monoclonal antibodies (MAbs). Enhancement of MAb tumor localization by hyperthermia also was proposed. Studies were to have been performed with both 18 F and 124 I; however, the lack of its availability (until quite recently) prevented experiments with 124 I. Instead, two additional lines of inquiry were initiated in which they utilized aspects of the radiofluorination chemistries originally developed for MAbs for labeling chemotactic peptides and meta-iodobenzylguanidine (MIBG) analogues with 18 F. This final report summarizes the original specific aims and the main research accomplishments in studies of mouse, dog and human models

  12. Bioconversion of coal derived synthesis gas to liquid fuels. Final quarterly technical progress report, July 1, 1993--September 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jain, M.K.; Worden, R.M.; Grethlein, H.

    1993-10-25

    The overall objective of the project is to develop an integrated two stage fermentation process for conversion of coal-derived synthesis gas to a mixture of alcohols. This is achieved in two steps. In the first step, Butyribacterium methylotrophicum converts carbon monoxide (CO) to butyric and acetic acids. Subsequent fermentation of the acids by Clostridium acetobutylicum leads to the production of butanol and ethanol. The tasks for this quarter were: (1) development/isolation of superior strains for fermentation of syngas, (2) optimization of process conditions for fermentation of syngas, (3) evaluation of bioreactor configuration for improved mass transfer of syngas, (4) development of a membrane-based pervaporation system, (5) optimization of process conditions for reducing carbon and electron loss by H{sub 2}-CO{sub 2} fermentation, and (6) synthesis gas fermentation in single-stage by co-culture. Progress is reported in isolation of CO utilizing anaerobic strains; investigating the product profile for the fermentation of syngas by B. methylotrophicum; and determining the effect of carbon monoxide on growth of C. acetobutylicum.

  13. Photosynthesis energy factory: analysis, synthesis, and demonstration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-11-01

    This quantitative assessment of the potential of a combined dry-land Energy Plantation, wood-fired power plant, and algae wastewater treatment system demonstrates the cost-effectiveness of recycling certain by-products and effluents from one subsystem to another. Designed to produce algae up to the limit of the amount of carbon in municipal wastewater, the algae pond provides a positive cash credit, resulting mainly from the wastewater treatment credit, which may be used to reduce the cost of the Photosynthesis Energy Factory (PEF)-generated electricity. The algae pond also produces fertilizer, which reduces the cost of the biomass produced on the Energy Plantation, and some gas. The cost of electricity was as low as 35 mills per kilowatt-hour for a typical municipally-owned PEF consisting of a 65-MWe power plant, a 144-acre algae pond, and a 33,000-acre Energy Plantation. Using only conventional or near-term technology, the most cost-effective algae pond for a PEF is the carbon-limited secondary treatment system. This system does not recycle CO/sub 2/ from the flue gas. Analysis of the Energy Plantation subsystem at 15 sites revealed that plantations of 24,000 to 36,000 acres produce biomass at the lowest cost per ton. The following sites are recommended for more detailed evaluation as potential demonstration sites: Pensacola, Florida; Jamestown, New York; Knoxville, Tennessee; Martinsville, Virginia, and Greenwood, South Carolina. A major possible extension of the PEF concept is to include the possibility for irrigation.

  14. Case study applications of venture analysis: fluidized bed. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Mosle, R.

    1978-05-01

    In order to appraise the case for government intervention in the case of atmospheric fluid-bed combustion, Energy Resources Company and Rotan Mosle have developed a methodology containing four key elements. The first is an economic and environmental characterization of the new technology; the second, a survey of its prospective users and vendors; the third, a cost-benefit analysis of its prospective social benefits; and the fourth, an analytical model of its market penetration and the effects thereon of a basket of government incentives. Three major technical obstacles exist to continued AFBC development: feeding coal and limestone reliably to the boiler, tube erosion and corrosion, and developing boiler turndown capability. The review of the economic, environmental and technical attributes of the new technology has suggested that the preliminary venture can be selected with confidence as a commercial prospect capable of detailed evaluation from both private and public perspectives. The venture choice can therefore be considered firm: it will be the equipment required for the combustion of coal in atmospheric fluid beds as applied to industrial process steam in boilers of at least 83 Kpph capacity. The most effective demonstration of the potential of AFBC in the eyes of prospective industrial users is that provided by a project conducted by the private sector with minimal government direction. Unlike the ''experimental'' style of existing mixed public-private demonstration projects, the pressure to achieve reliability in more commercial applications would serve rapidly to reveal more clearly the potential of AFBC. The marketplace can be allowed to decide its fate thereafter. Once AFBC has been successfully demonstrated, the relative merits of AFBC and coal-FGD are best left to prospective users to evaluate.

  15. Purchase of a PhosphorImager System for plant biology research. Final progress report, July 1992--July 1994

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, A.O.

    1993-10-01

    Eight DOE supported plant biologists at the University of California-Berkeley were awarded funds ($163,000) for purchase of a Phosphorlmager System to improve the speed, sensitivity, resolution, and quantitation of radioactive data processing and analysis. These funds were used to purchase a Molecular Dynamics Phosphorlmager System consisting of the phosphorlmager, a densitometer, and high resolution storage phosphor screens that have extremely high trapping and storage capacity for energy emitted from isotopes used for biological research such as {sup 32}P, {sup 14}C, {sup 35}S, and {sup 125}I. Software provided with the package permits analysis of the data in several unique ways that are not currently feasible With other methods for analysis. The University of California has purchased additional computer hardware (A MacIntosh Quadra 800 Computer) and has upgraded an IBM computer Mod6l PS2-486 linked with on-line and on off-line workstations via ethernet systems for analysis of data. Data files can also be converted to a TIFF format suitable for graphic analysis and image production on the MacIntosh computer. The system is providing unique advantages for quantitation of data over extremely wide ranges of isotope levels and provides the ability to analyze and manipulate data over wide ranges of sensitivity not previously available with previously used methods of isotope quantitation.

  16. Does smoking reduce the progression of osteoarthritis? Meta-analysis of observational studies.

    Science.gov (United States)

    Pearce, Fiona; Hui, Michelle; Ding, Changhai; Doherty, Michael; Zhang, Weiya

    2013-07-01

    To determine whether smoking reduces the progression of osteoarthritis (OA). Observational studies examining smoking and progression of OA were systematically searched through Medline (1948-), EMBase (1980-), Web of Science, PubMed, and Google and relevant references. The search was last updated in May 2012. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were directly retrieved or calculated. Current standards for reporting meta-analyses of observational studies (Meta-Analysis of Observational Studies in Epidemiology) were followed. Quality-related aspects such as study design, setting, sample selection, definition of progression, and confounding bias were recorded. Stratified and meta-regression analyses were undertaken to examine the covariates. Sixteen studies (976,564 participants) were identified from the literature. Overall, there was no significant association between smoking and progression of OA (OR 0.92; 95% CI 0.83, 1.02). There was moderate heterogeneity of results (I(2) = 57.3%, P = 0.0024). Subgroup analyses showed some associations of marginal significance; however, meta-regression did not confirm any significant results. There is no compelling evidence that smoking has a protective effect on the progression of OA. The results concur with a previous meta-analysis published by this group that showed no association between smoking and incidence of OA. Taken together, smoking does not appear to reduce either the incidence or progression of OA. Copyright © 2013 by the American College of Rheumatology.

  17. Hybrid solar thermal-photovoltaic systems demonstration, Phase I and II. Final technical progress report, July 5, 1979-December 1982

    Energy Technology Data Exchange (ETDEWEB)

    Loferski, J.J. (ed.)

    1983-12-01

    The purpose of the project is to investigate a system based on combined photovoltaic/thermal (PV/T) panels to supply the energy needs of a small single family residence. The system finally selected and constructed uses PV/T panels which utilize air as the heat transfer medium. Optimization of thermal performance was accomplished by attaching metal fins to the back surface of each cell which significantly increased the heat transfer coefficient from the solar cells to the air stream. The other major components of the selected system are an air-to-air heat pump, a rock bin thermal energy storage bin, a synchronous dc-to-ac converter, a microprocessor to control the system, a heat exchanger for the domestic hot water system and of course the building itself which is a one story, well insulated structure having a floor area of 1200 ft/sup 2/. A prototype collector was constructed and tested. Based on this experience, twenty collectors, containing 2860 four inch diameter solar cells, were constructed and installed on the building. Performance of the system was simulated using a TRNSYS-derived program, modified to accommodate PV/T panels and to include the particular components included in the selected system. Simulation of the performance showed that about 65 percent of the total annual energy needs of the building would be provided by the PV/T system. Of this total, about one half is produced at a time when it can be used in the building and one half must be sold back to the utility.

  18. Evaluation of Progressive Failure Analysis and Modeling of Impact Damage in Composite Pressure Vessels

    Science.gov (United States)

    Sanchez, Christopher M.

    2011-01-01

    NASA White Sands Test Facility (WSTF) is leading an evaluation effort in advanced destructive and nondestructive testing of composite pressure vessels and structures. WSTF is using progressive finite element analysis methods for test design and for confirmation of composite pressure vessel performance. Using composite finite element analysis models and failure theories tested in the World-Wide Failure Exercise, WSTF is able to estimate the static strength of composite pressure vessels. Additionally, test and evaluation on composites that have been impact damaged is in progress so that models can be developed to estimate damage tolerance and the degradation in static strength.

  19. Joint application of AI techniques, PRA and disturbance analysis methodology to problems in the maintenance and design of nuclear power plants. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Okrent, D.

    1989-03-01

    This final report summarizes the accomplishments of a two year research project entitled ``Joint Application of Artificial Intelligence Techniques, Probabilistic Risk Analysis, and Disturbance Analysis Methodology to Problems in the Maintenance and Design of Nuclear Power Plants. The objective of this project is to develop and apply appropriate combinations of techniques from artificial intelligence, (AI), reliability and risk analysis and disturbance analysis to well-defined programmatic problems of nuclear power plants. Reactor operations issues were added to those of design and maintenance as the project progressed.

  20. Performance of confocal scanning laser tomograph Topographic Change Analysis (TCA) for assessing glaucomatous progression.

    Science.gov (United States)

    Bowd, Christopher; Balasubramanian, Madhusudhanan; Weinreb, Robert N; Vizzeri, Gianmarco; Alencar, Luciana M; O'Leary, Neil; Sample, Pamela A; Zangwill, Linda M

    2009-02-01

    To determine the sensitivity and specificity of confocal scanning laser ophthalmoscope's Topographic Change Analysis (TCA; Heidelberg Retina Tomograph [HRT]; Heidelberg Engineering, Heidelberg, Germany) parameters for discriminating between progressing glaucomatous and stable healthy eyes. The 0.90, 0.95, and 0.99 specificity cutoffs for various (n=70) TCA parameters were developed by using 1000 permuted topographic series derived from HRT images of 18 healthy eyes from Moorfields Eye Hospital, imaged at least four times. The cutoffs were then applied to topographic series from 36 eyes with known glaucomatous progression (by optic disc stereophotograph assessment and/or standard automated perimetry guided progression analysis, [GPA]) and 21 healthy eyes from the University of California, San Diego (UCSD) Diagnostic Innovations in Glaucoma Study (DIGS), all imaged at least four times, to determine TCA sensitivity and specificity. Cutoffs also were applied to 210 DIGS patients' eyes imaged at least four times with no evidence of progression (nonprogressed) by stereophotography or GPA. The TCA parameter providing the best sensitivity/specificity tradeoff using the 0.90, 0.95, and 0.99 cutoffs was the largest clustered superpixel area within the optic disc margin (CAREA(disc) mm(2)). Sensitivities/specificities for classifying progressing (by stereophotography and/or GPA) and healthy eyes were 0.778/0.809, 0.639/0.857, and 0.611/1.00, respectively. In nonprogressing eyes, specificities were 0.464, 0.570, and 0.647 (i.e., lower than in the healthy eyes). In addition, TCA parameter measurements of nonprogressing eyes were similar to those of progressing eyes. TCA parameters can discriminate between progressing and longitudinally observed healthy eyes. Low specificity in apparently nonprogressing patients' eyes suggests early progression detection using TCA.

  1. Fundamental studies of stress distributions and stress relaxation in oxide scales on high temperature alloys. [Final progress report

    Energy Technology Data Exchange (ETDEWEB)

    Shores, D.A.; Stout, J.H.; Gerberich, W.W.

    1993-06-01

    This report summarizes a three-year study of stresses arising in the oxide scale and underlying metal during high temperature oxidation and of scale cracking. In-situ XRD was developed to measure strains during oxidation over 1000{degrees}C on pure metals. Acoustic emission was used to observe scale fracture during isothermal oxidation and cooling, and statistical analysis was used to infer mechanical aspects of cracking. A microscratch technique was used to measure the fracture toughness of scale/metal interface. A theoretical model was evaluated for the development and relaxation of stresses in scale and metal substrate during oxidation.

  2. Progression Analysis and Stage Discovery in Continuous Physiological Processes Using Image Computing

    Directory of Open Access Journals (Sweden)

    Ferrucci Luigi

    2010-01-01

    Full Text Available We propose an image computing-based method for quantitative analysis of continuous physiological processes that can be sensed by medical imaging and demonstrate its application to the analysis of morphological alterations of the bone structure, which correlate with the progression of osteoarthritis (OA. The purpose of the analysis is to quantitatively estimate OA progression in a fashion that can assist in understanding the pathophysiology of the disease. Ultimately, the texture analysis will be able to provide an alternative OA scoring method, which can potentially reflect the progression of the disease in a more direct fashion compared to the existing clinically utilized classification schemes based on radiology. This method can be useful not just for studying the nature of OA, but also for developing and testing the effect of drugs and treatments. While in this paper we demonstrate the application of the method to osteoarthritis, its generality makes it suitable for the analysis of other progressive clinical conditions that can be diagnosed and prognosed by using medical imaging.

  3. Progress Towards Improved Analysis of TES X-ray Data Using Principal Component Analysis

    Science.gov (United States)

    Busch, S. E.; Adams, J. S.; Bandler, S. R.; Chervenak, J. A.; Eckart, M. E.; Finkbeiner, F. M.; Fixsen, D. J.; Kelley, R. L.; Kilbourne, C. A.; Lee, S.-J.; hide

    2015-01-01

    The traditional method of applying a digital optimal filter to measure X-ray pulses from transition-edge sensor (TES) devices does not achieve the best energy resolution when the signals have a highly non-linear response to energy, or the noise is non-stationary during the pulse. We present an implementation of a method to analyze X-ray data from TESs, which is based upon principal component analysis (PCA). Our method separates the X-ray signal pulse into orthogonal components that have the largest variance. We typically recover pulse height, arrival time, differences in pulse shape, and the variation of pulse height with detector temperature. These components can then be combined to form a representation of pulse energy. An added value of this method is that by reporting information on more descriptive parameters (as opposed to a single number representing energy), we generate a much more complete picture of the pulse received. Here we report on progress in developing this technique for future implementation on X-ray telescopes. We used an 55Fe source to characterize Mo/Au TESs. On the same dataset, the PCA method recovers a spectral resolution that is better by a factor of two than achievable with digital optimal filters.

  4. Development and fabrication of a dragline training system. Technical progress report, No. 1 (phase 1 final report)

    Energy Technology Data Exchange (ETDEWEB)

    Voss, William J.

    1979-09-17

    As a result of the task analysis and revision to the plan of instruction, certain desirable characteristics were recommended to be added to the dragline trainer. These essentially would provide for a high quality feedback and hard copy record of the trainee's performance. It was recommended that the trainer be able to produce and/or sense and record: drag and hoist over-spooling, dragchain/cone contact, bucket shock, bucket stall, lateral boom stress, tight lining, excessive rapid braking and reaction times to internal/external alarms. In addition, data such as cycle time, bucket position, yardage moved and cycles completed should be recorded and records printed. With the exception of drag chain and cone contact indications, these characteristics can be implemented in the computer program. In some cases, such as bucket stall and external alarms it will require instructor initiative to activate specific trainer scenario and reaction time measurements. It should be noted that these additional features, however desirable, add significantly to the required computer capability. Both processor cycle time and memory availability could be restraints. A faster, and larger system could accommodate these added features but at an increase in cost for the computer system. A study is in process and specific recommendations will result.

  5. Increased bone turnover, osteoporosis, progressive tibial bowing, fractures, and scoliosis in a patient with a final-exon SATB2 frameshift mutation.

    Science.gov (United States)

    Boone, Philip M; Chan, Yiu Man; Hunter, Jill V; Pottkotter, Louis E; Davino, Nelson A; Yang, Yaping; Beuten, Joke; Bacino, Carlos A

    2016-11-01

    Haploinsufficiency of SATB2 causes cleft palate, intellectual disability with deficient speech, facial and dental abnormalities, and other variable features known collectively as SATB2-associated syndrome. This phenotype was accompanied by osteoporosis, fractures, and tibial bowing in two previously reported adult patients; each possessed SATB2 mutations either predicted or demonstrated to escape nonsense-mediated decay, suggesting that the additional bone defects result from a dominant negative effect and/or age-dependent penetrance. These hypotheses remain to be confirmed, as do the specific downstream defects causing bone abnormalities. We report a SATB2 mutation (c.2018dupA; p.(H673fs)) in a 15-year-old patient whose SATB2-associated syndrome phenotype is accompanied by osteoporosis, fractures, progressive tibial bowing, and scoliosis. As this homeodomain-disrupting and predicted truncating mutation resides within the final exon of SATB2, escape from nonsense-mediated decay is likely. Thus, we provide further evidence of bone phenotypes beyond those typically associated with SATB2-associated syndrome in individuals with potential dominant-negative SATB2 alleles, as well as evidence for age-dependence of bone features. Elevations in alkaline phosphatase, urinary N-telopeptide/creatinine ratio, and osteocalcin in the patient indicate increased bone turnover. We propose surveillance and treatment with osteoclast inhibitors to prevent fractures and to slow progressive bone deformities. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  6. Event-by-Event Cluster Analysis of Final States from Heavy Ion Collisions

    International Nuclear Information System (INIS)

    Fialkowski, K.; Wit, R.

    1999-01-01

    We present an event-by-event analysis of the cluster structure of final multihadron states resulting from heavy ion collisions. A comparison of experimental data with the states obtained from Monte Carlo generators is shown. The analysis of the first available experimental events suggests that the method is suitable for selecting some different types of events. (author)

  7. 77 FR 47495 - Final Priority; Technical Assistance on State Data Collection, Analysis, and Reporting-National...

    Science.gov (United States)

    2012-08-08

    ... Priority; Technical Assistance on State Data Collection, Analysis, and Reporting--National IDEA Technical... 34 CFR Chapter III [CFDA Number 84.373Z] Final Priority; Technical Assistance on State Data Collection, Analysis, and Reporting--National IDEA Technical Assistance Center on Early Childhood...

  8. 1985. Annual progress report

    International Nuclear Information System (INIS)

    1986-01-01

    This annual progress report of the CEA Protection and Nuclear Safety Institut outlines a description of the progress made in each sections of the Institut Research activities of the different departments include: reactor safety analysis, fuel cycle facilities analysis; and associated safety research programs (criticality, sites, transport ...), radioecology and environmental radioprotection techniques; data acquisition on radioactive waste storage sites; radiation effects on man, studies on radioprotection techniques; nuclear material security including security of facilities, security of nuclear material transport, and monitoring of nuclear material management; nuclear facility decommissioning; and finally the public information [fr

  9. A meta-analysis on progressive atrophy in intractable temporal lobe epilepsy: Time is brain?

    Science.gov (United States)

    Caciagli, Lorenzo; Bernasconi, Andrea; Wiebe, Samuel; Koepp, Matthias J; Bernasconi, Neda; Bernhardt, Boris C

    2017-08-01

    It remains unclear whether drug-resistant temporal lobe epilepsy (TLE) is associated with cumulative brain damage, with no expert consensus and no quantitative syntheses of the available evidence. We conducted a systematic review and meta-analysis of MRI studies on progressive atrophy, searching PubMed and Ovid MEDLINE databases for cross-sectional and longitudinal quantitative MRI studies on drug-resistant TLE. We screened 2,976 records and assessed eligibility of 248 full-text articles. Forty-two articles met the inclusion criteria for quantitative evaluation. We observed a predominance of cross-sectional studies, use of different clinical indices of progression, and high heterogeneity in age-control procedures. Meta-analysis of 18/1 cross-sectional/longitudinal studies on hippocampal atrophy (n = 979 patients) yielded a pooled effect size of r = -0.42 for ipsilateral atrophy related to epilepsy duration (95% confidence interval [CI] -0.51 to -0.32; p atrophy (n = 1,504 patients) indicated that >80% of articles reported duration-related progression in extratemporal cortical and subcortical regions. Detailed analysis of study design features yielded low to moderate levels of evidence for progressive atrophy across studies, mainly due to dominance of cross-sectional over longitudinal investigations, use of diverse measures of seizure estimates, and absence of consistent age control procedures. While the neuroimaging literature is overall suggestive of progressive atrophy in drug-resistant TLE, published studies have employed rather weak designs to directly demonstrate it. Longitudinal multicohort studies are needed to unequivocally differentiate aging from disease progression. © 2017 American Academy of Neurology.

  10. Flexible Multibody Dynamics Finite Element Formulation Applied to Structural Progressive Collapse Analysis

    Directory of Open Access Journals (Sweden)

    Rodolfo André Kuche Sanches

    Full Text Available Abstract This paper presents a two-dimensional frame finite element methodology to deal with flexible multi-body dynamic systems and applies it to building progressive collapse analysis. The proposed methodology employs a frame element with Timoshenko kinematics and the dynamic governing equation is solved based on the stationary potential energy theorem written regarding nodal positions and generalized vectors components instead of displacements and rotations. The bodies are discretized by lose finite elements, which are assembled by Lagrange multipliers in order to make possible dynamical detachment. Due to the absence of rotation, the time integration is carried by classical Newmark algorithm, which reveals to be stable to the position based formulation. The accuracy of the proposed formulation is verified by simple examples and its capabilities regarding progressive collapse analysis is demonstrated in a more complete building analysis.

  11. The Application of Structured Job Analysis Information Based on the Position Analysis Questionnaire (PAQ). Final Report No. 9.

    Science.gov (United States)

    McCormick, Ernest J.

    The Position Analysis Questionnaire (PAQ) is a job analysis instrument consisting of 187 job elements organized into six divisions. The PAQ was used in the eight studies summarized in this final report. The studies were: (1) ratings of the attribute requirements of PAQ job elements, (2) a series of principal components analyses of these attribute…

  12. Analysis of Muscle Fatigue Progression using Cyclostationary Property of Surface Electromyography Signals.

    Science.gov (United States)

    Karthick, P A; Venugopal, G; Ramakrishnan, S

    2016-01-01

    Analysis of neuromuscular fatigue finds various applications ranging from clinical studies to biomechanics. Surface electromyography (sEMG) signals are widely used for these studies due to its non-invasiveness. During cyclic dynamic contractions, these signals are nonstationary and cyclostationary. In recent years, several nonstationary methods have been employed for the muscle fatigue analysis. However, cyclostationary based approach is not well established for the assessment of muscle fatigue. In this work, cyclostationarity associated with the biceps brachii muscle fatigue progression is analyzed using sEMG signals and Spectral Correlation Density (SCD) functions. Signals are recorded from fifty healthy adult volunteers during dynamic contractions under a prescribed protocol. These signals are preprocessed and are divided into three segments, namely, non-fatigue, first muscle discomfort and fatigue zones. Then SCD is estimated using fast Fourier transform accumulation method. Further, Cyclic Frequency Spectral Density (CFSD) is calculated from the SCD spectrum. Two features, namely, cyclic frequency spectral area (CFSA) and cyclic frequency spectral entropy (CFSE) are proposed to study the progression of muscle fatigue. Additionally, degree of cyclostationarity (DCS) is computed to quantify the amount of cyclostationarity present in the signals. Results show that there is a progressive increase in cyclostationary during the progression of muscle fatigue. CFSA shows an increasing trend in muscle fatiguing contraction. However, CFSE shows a decreasing trend. It is observed that when the muscle progresses from non-fatigue to fatigue condition, the mean DCS of fifty subjects increases from 0.016 to 0.99. All the extracted features found to be distinct and statistically significant in the three zones of muscle contraction (p < 0.05). It appears that these SCD features could be useful in the automated analysis of sEMG signals for different neuromuscular conditions.

  13. Assessing Progress towards Public Health, Human Rights, and International Development Goals Using Frontier Analysis.

    Science.gov (United States)

    Luh, Jeanne; Cronk, Ryan; Bartram, Jamie

    2016-01-01

    Indicators to measure progress towards achieving public health, human rights, and international development targets, such as 100% access to improved drinking water or zero maternal mortality ratio, generally focus on status (i.e., level of attainment or coverage) or trends in status (i.e., rates of change). However, these indicators do not account for different levels of development that countries experience, thus making it difficult to compare progress between countries. We describe a recently developed new use of frontier analysis and apply this method to calculate country performance indices in three areas: maternal mortality ratio, poverty headcount ratio, and primary school completion rate. Frontier analysis is used to identify the maximum achievable rates of change, defined by the historically best-performing countries, as a function of coverage level. Performance indices are calculated by comparing a country's rate of change against the maximum achievable rate at the same coverage level. A country's performance can be positive or negative, corresponding to progression or regression, respectively. The calculated performance indices allow countries to be compared against each other regardless of whether they have only begun to make progress or whether they have almost achieved the target. This paper is the first to use frontier analysis to determine the maximum achievable rates as a function of coverage level and to calculate performance indices for public health, human rights, and international development indicators. The method can be applied to multiple fields and settings, for example health targets such as cessation in smoking or specific vaccine immunizations, and offers both a new approach to analyze existing data and a new data source for consideration when assessing progress achieved.

  14. User-defined Material Model for Thermo-mechanical Progressive Failure Analysis

    Science.gov (United States)

    Knight, Norman F., Jr.

    2008-01-01

    Previously a user-defined material model for orthotropic bimodulus materials was developed for linear and nonlinear stress analysis of composite structures using either shell or solid finite elements within a nonlinear finite element analysis tool. Extensions of this user-defined material model to thermo-mechanical progressive failure analysis are described, and the required input data are documented. The extensions include providing for temperature-dependent material properties, archival of the elastic strains, and a thermal strain calculation for materials exhibiting a stress-free temperature.

  15. Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT): Semi-Annual Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, D N

    2012-02-29

    This report summarizes work carried out by the Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) Team for the period of July 1, 2011 through December 31, 2011. It discusses highlights, overall progress, period goals, and collaborations and lists papers and presentations. The UV-CDAT team is positioned to address the following high-level visualization requirements: (1) Alternative parallel streaming statistics and analysis pipelines - Data parallelism, Task parallelism, Visualization parallelism; (2) Optimized parallel input/output (I/O); (3) Remote interactive execution; (4) Advanced intercomparison visualization; (5) Data provenance processing and capture; and (6) Interfaces for scientists - Workflow data analysis and visualization construction tools, Visualization interfaces.

  16. Small Renal Masses Progressing to Metastases under Active Surveillance: A Systematic Review and Pooled Analysis

    Science.gov (United States)

    Smaldone, Marc C.; Kutikov, Alexander; Egleston, Brian L.; Canter, Daniel J.; Viterbo, Rosalia; Chen, David Y.T.; Jewett, Michael A.; Greenberg, Richard E.; Uzzo, Robert G.

    2012-01-01

    Purpose We conducted a systematic review and pooled analysis of small renal masses under active surveillance to identify progression risk and characteristics associated with metastases. Materials and Methods A MEDLINE search was performed to identify all clinical series reporting surveillance of localized renal masses. For studies reporting individual level data, clinical and radiographic characteristics of tumors without progression were compared to those progressing to metastases. Results 18 series (880 patients, 936 masses) met screening criteria from which 18 patients progressing to metastasis were identified (mean 40.2 months). Six studies (259 patients, 284 masses) provided individual level data for pooled analysis. With a mean follow up of 33.5±22.6 months, mean initial tumor diameter was 2.3±1.3 cm and mean linear growth rate was 0.31±0.38 cm/year. 65 masses (23%) exhibited zero net growth under surveillance; of which none progressed to metastasis. Pooled analysis revealed increased age (75.1±9.1 vs. 66.6±12.3 years, p=0.03), initial tumor diameter (4.1±2.1 vs. 2.3±1.3 cm, p<0.0001), initial estimated tumor volume (66.3±100.0 vs. 15.1±60.3 cm3, p<0.0001), linear growth rate (0.8±0.65 vs. 0.3±0.4 cm/yr, p=0.0001), and volumetric growth rate (27.1±24.9 vs. 6.2±27.5 cm3/yr, p<0.0001) in the progression cohort. Conclusions A substantial proportion of small renal masses remain radiographically static following an initial period of active surveillance. Progression to metastases occurs in a small percentage of patients and is generally a late event. These results indicate that in patients with competing health risks, radiographic surveillance may be an acceptable initial approach with delayed intervention reserved for those exhibiting significant linear or volumetric growth. PMID:21766302

  17. Rates of progression in diabetic retinopathy during different time periods: a systematic review and meta-analysis

    DEFF Research Database (Denmark)

    Wong, Tien Y; Mwamburi, Mkaya; Klein, Ronald

    2009-01-01

    This meta-analysis reviews rates of progression of diabetic retinopathy to proliferative diabetic retinopathy (PDR) and/or severe visual loss (SVL) and temporal trends.......This meta-analysis reviews rates of progression of diabetic retinopathy to proliferative diabetic retinopathy (PDR) and/or severe visual loss (SVL) and temporal trends....

  18. Pregnancy and HIV disease progression: a systematic review and meta-analysis.

    Science.gov (United States)

    Calvert, Clara; Ronsmans, Carine

    2015-02-01

    To assess whether pregnancy accelerates HIV disease progression. Studies comparing progression to HIV-related illness, low CD4 count, AIDS-defining illness, HIV-related death, or any death in HIV-infected pregnant and non-pregnant women were included. Relative risks (RR) for each outcome were combined using random effects meta-analysis and were stratified by antiretroviral therapy (ART) availability. 15 studies met the inclusion criteria. Pregnancy was not associated with progression to HIV-related illness [summary RR: 1.32, 95% confidence interval (CI): 0.66-2.61], AIDS-defining illness (summary RR: 0.97, 95% CI: 0.74-1.25) or mortality (summary RR: 0.97, 95% CI: 0.62-1.53), but there was an association with low CD4 counts (summary RR: 1.41, 95% CI: 0.99-2.02) and HIV-related death (summary RR: 1.65, 95% CI: 1.06-2.57). In settings where ART was available, there was no evidence that pregnancy accelerated progress to HIV/AIDS-defining illnesses, death and drop in CD4 count. In settings without ART availability, effect estimates were consistent with pregnancy increasing the risk of progression to HIV/AIDS-defining illnesses and HIV-related or all-cause mortality, but there were too few studies to draw meaningful conclusions. In the absence of ART, pregnancy is associated with small but appreciable increases in the risk of several negative HIV outcomes, but the evidence is too weak to draw firm conclusions. When ART is available, the effects of pregnancy on HIV disease progression are attenuated and there is little reason to discourage healthy HIV-infected women who desire to become pregnant from doing so. © 2014 John Wiley & Sons Ltd.

  19. Nonlinear analysis of the progressive collapse of reinforced concrete plane frames using a multilayered beam formulation

    Directory of Open Access Journals (Sweden)

    C. E. M. Oliveira

    Full Text Available This work investigates the response of two reinforced concrete (RC plane frames after the loss of a column and their potential resistance for progressive collapse. Nonlinear dynamic analysis is performed using a multilayered Euler/Bernoulli beam element, including elasto-viscoplastic effects. The material nonlinearity is represented using one-dimensional constitutive laws in the material layers, while geometrical nonlinearities are incorporated within a corotational beam formulation. The frames were designed in accordance with the minimum requirements proposed by the reinforced concrete design/building codes of Europe (fib [1-2], Eurocode 2 [3] and Brazil (NBR 6118 [4]. The load combinations considered for PC analysis follow the prescriptions of DoD [5]. The work verifies if the minimum requirements of the considered codes are sufficient for enforcing structural safety and robustness, and also points out the major differences in terms of progressive collapse potential of the corresponding designed structures.

  20. Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis

    DEFF Research Database (Denmark)

    Walsh, Michael; Catapano, Fausta; Szpirt, Wladimir

    2010-01-01

    BACKGROUND:: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. STUDY DESIGN:: Systematic review and meta-analysis of articles identified from...... electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. SETTING & POPULATION:: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. SELECTION CRITERIA FOR STUDIES:: Randomized controlled trials that compared...... standard care with standard care plus adjuvant plasma exchange in adult patients with either renal vasculitis or idiopathic rapidly progressive glomerulonephritis. INTERVENTION:: Adjuvant plasma exchange. OUTCOME:: Composite of end-stage renal disease or death. RESULTS:: We identified 9 trials including...

  1. High beta and second stability region transport and stability analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, M.H.; Phillips, M.W.

    1996-01-01

    This report describes MHD equilibrium and stability studies carried out at Northrop Grumman`s Advanced Technology and Development Center during the period March 1 to December 31, 1995. Significant progress is reported in both ideal and resistive MHD modeling of TFTR plasmas. Specifically, attention is concentrated on analysis of Advanced Tokamak experiments at TFTR involving plasmas in which the q-profiles were non-monotonic.

  2. Spent nuclear fuel project - criteria document spent nuclear fuel final safety analysis report

    International Nuclear Information System (INIS)

    MORGAN, R.G.

    1999-01-01

    The criteria document provides the criteria and planning guidance for developing the Spent Nuclear Fuel (SNF) Final Safety Analysis Report (FSAR). This FSAR will support the US Department of Energy, Richland Operations Office decision to authorize the procurement, installation, installation acceptance testing, startup, and operation of the SNF Project facilities (K Basins, Cold Vacuum Drying Facility, and Canister Storage Building)

  3. Who pays for healthcare in Bangladesh? An analysis of progressivity in health systems financing.

    Science.gov (United States)

    Molla, Azaher Ali; Chi, Chunhuei

    2017-09-06

    The relationship between payments towards healthcare and ability to pay is a measure of financial fairness. Analysis of progressivity is important from an equity perspective as well as for macroeconomic and political analysis of healthcare systems. Bangladesh health systems financing is characterized by high out-of-pocket payments (63.3%), which is increasing. Hence, we aimed to see who pays what part of this high out-of-pocket expenditure. To our knowledge, this was the first progressivity analysis of health systems financing in Bangladesh. We used data from Bangladesh Household Income and Expenditure Survey, 2010. This was a cross sectional and nationally representative sample of 12,240 households consisting of 55,580 individuals. For quantification of progressivity, we adopted the 'ability-to-pay' principle developed by O'Donnell, van Doorslaer, Wagstaff, and Lindelow (2008). We used the Kakwani index to measure the magnitude of progressivity. Health systems financing in Bangladesh is regressive. Inequality increases due to healthcare payments. The differences between the Gini coefficient and the Kakwani index for all sources of finance are negative, which indicates regressivity, and that financing is more concentrated among the poor. Income inequality increases due to high out-of-pocket payments. The increase in income inequality caused by out-of-pocket payments is 89% due to negative vertical effect and 11% due to horizontal inequity. Our findings add substantial evidence of health systems financing impact on inequitable financial burden of healthcare and income. The heavy reliance on out-of-pocket payments may affect household living standards. If the government and people of Bangladesh are concerned about equitable financing burden, our study suggests that Bangladesh needs to reform the health systems financing scheme.

  4. A genetic analysis of Adh1 regulation. Progress report, June 1991--February 1992

    Energy Technology Data Exchange (ETDEWEB)

    Freeling, M.

    1992-03-01

    The overall goal of our research proposal is to understand the meaning of the various cis-acting sites responsible for AdH1 expression in the entire maize plant. Progress is reported in the following areas: Studies on the TATA box and analysis of revertants of the Adh1-3F1124 allele; screening for more different mutants that affect Adh1 expression differentially; studies on cis-acting sequences required for root-specific Adh1 expression; refinement of the use of the particle gun; and functional analysis of a non- glycolytic anaerobic protein.

  5. Progress in the RAMI analysis of a conceptual LHCD system for DEMO

    Energy Technology Data Exchange (ETDEWEB)

    Mirizzi, F. [Associazione EURATOM-ENEA sulla Fusione, Consorzio CREATE, Università degli Studi di Napoli Federico II, Via Claudio 21, 80125, Napoli (Italy)

    2014-02-12

    Reliability, Availability, Maintainability and Inspectability (RAMI) concepts and techniques, that acquired great importance during the first manned space missions, have been progressively extended to industrial, scientific and consumer equipments to assure them satisfactory performances and lifetimes. In the design of experimental facilities, like tokamaks, mainly aimed at demonstrating validity and feasibility of scientific theories, RAMI analysis has been often left aside. DEMO, the future prototype fusion reactors, will be instead designed for steadily delivering electrical energy to commercial grids, so that the RAMI aspects will assume an absolute relevance since their initial design phases. A preliminary RAMI analysis of the LHCD system for the conceptual EU DEMO reactor is given in the paper.

  6. Progress in the RAMI analysis of a conceptual LHCD system for DEMO

    International Nuclear Information System (INIS)

    Mirizzi, F.

    2014-01-01

    Reliability, Availability, Maintainability and Inspectability (RAMI) concepts and techniques, that acquired great importance during the first manned space missions, have been progressively extended to industrial, scientific and consumer equipments to assure them satisfactory performances and lifetimes. In the design of experimental facilities, like tokamaks, mainly aimed at demonstrating validity and feasibility of scientific theories, RAMI analysis has been often left aside. DEMO, the future prototype fusion reactors, will be instead designed for steadily delivering electrical energy to commercial grids, so that the RAMI aspects will assume an absolute relevance since their initial design phases. A preliminary RAMI analysis of the LHCD system for the conceptual EU DEMO reactor is given in the paper

  7. Progress in the RAMI analysis of a conceptual LHCD system for DEMO

    Science.gov (United States)

    Mirizzi, F.

    2014-02-01

    Reliability, Availability, Maintainability and Inspectability (RAMI) concepts and techniques, that acquired great importance during the first manned space missions, have been progressively extended to industrial, scientific and consumer equipments to assure them satisfactory performances and lifetimes. In the design of experimental facilities, like tokamaks, mainly aimed at demonstrating validity and feasibility of scientific theories, RAMI analysis has been often left aside. DEMO, the future prototype fusion reactors, will be instead designed for steadily delivering electrical energy to commercial grids, so that the RAMI aspects will assume an absolute relevance since their initial design phases. A preliminary RAMI analysis of the LHCD system for the conceptual EU DEMO reactor is given in the paper.

  8. Agreement among graders on Heidelberg retina tomograph (HRT) topographic change analysis (TCA) glaucoma progression interpretation.

    Science.gov (United States)

    Iester, Michele M; Wollstein, Gadi; Bilonick, Richard A; Xu, Juan; Ishikawa, Hiroshi; Kagemann, Larry; Schuman, Joel S

    2015-04-01

    To evaluate agreement among experts of Heidelberg retina tomography's (HRT) topographic change analysis (TCA) printout interpretations of glaucoma progression and explore methods for improving agreement. 109 eyes of glaucoma, glaucoma suspect and healthy subjects with ≥5 visits and 2 good quality HRT scans acquired at each visit were enrolled. TCA printouts were graded as progression or non-progression. Each grader was presented with 2 sets of tests: a randomly selected single test from each visit and both tests from each visit. Furthermore, the TCA printouts were classified with grader's individual criteria and with predefined criteria (reproducible changes within the optic nerve head, disregarding changes along blood vessels or at steep rim locations and signs of image distortion). Agreement among graders was modelled using common latent factor measurement error structural equation models for ordinal data. Assessment of two scans per visit without using the predefined criteria reduced overall agreement, as indicated by a reduction in the slope, reflecting the correlation with the common factor, for all graders with no effect on reducing the range of the intercepts between the graders. Using the predefined criteria improved grader agreement, as indicated by the narrower range of intercepts among the graders compared with assessment using individual grader's criteria. A simple set of predefined common criteria improves agreement between graders in assessing TCA progression. The inclusion of additional scans from each visit does not improve the agreement. We, therefore, recommend setting standardised criteria for TCA progression evaluation. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  9. Multi-platform genome-wide analysis of melanoma progression to brain metastasis

    Directory of Open Access Journals (Sweden)

    Diego M. Marzese

    2014-12-01

    Full Text Available Melanoma has a high tendency to metastasize to brain tissue. The understanding about the molecular alterations of early-stage melanoma progression to brain metastasis (MBM is very limited. Identifying MBM-specific genomic and epigenomic alterations is a key initial step in understanding its aggressive nature and identifying specific novel druggable targets. Here, we describe a multi-platform dataset generated with different stages of melanoma progression to MBM. This data includes genome-wide DNA methylation (Illumina HM450K BeadChip, gene expression (Affymetrix HuEx 1.0 ST array, single nucleotide polymorphisms (SNPs and copy number variation (CNV; Affymetrix SNP 6.0 array analyses of melanocyte cells (MNCs, primary melanoma tumors (PRMs, lymph node metastases (LNMs and MBMs. The analysis of this data has been reported in our recently published study (Marzese et al., 2014.

  10. Short analysis of a progressive distorsion problem (tension and cyclic torsion)

    International Nuclear Information System (INIS)

    Roche, Roland.

    1978-06-01

    Tests on ratcheting (or progressive distorsion) are in progress in Saclay. A thin tube is subjected to a constant tensile load and to a cyclic twist. The present paper is a short theoretial analysis of that case. A uniform strain and stress field is considered with a constant tensile stress P (primary stress) and a cyclic shearing strain. The shearing strain is known by the corresponding elastic equivalent stress intensity (TRESCA criterion). The cyclic range of the stress intensity is ΔQ (secondary stress range). Are examined the shake down condition and the incremental elongations with different constitutive equations of the material. Special attention is given to perfect plasticity and bilinear kinematic hardening results are presented, but it is believed that these materials mathematical models are simplistic and special experimental tests are proposed [fr

  11. HIV disease progression by hormonal contraceptive method: secondary analysis of a randomized trial.

    Science.gov (United States)

    Stringer, Elizabeth M; Levy, Jens; Sinkala, Moses; Chi, Benjamin H; Matongo, Inutu; Chintu, Namwinga; Stringer, Jeffrey S A

    2009-07-17

    HIV-infected women need access to safe contraception. We hypothesized that women using depomedroxyprogesterone acetate (DMPA) contraception would have faster HIV disease progression than women using oral contraceptive pills (OCPs) and nonhormonal methods. In a previously reported trial, we randomized 599 HIV-infected women to the intrauterine device (IUD) or hormonal contraception. Women randomized to hormonal contraception chose between OCPs and DMPA. This analysis investigates the relationship between exposure to hormonal contraception and HIV disease progression [defined as death, becoming eligible for antiretroviral therapy (ART), or both]. Of the 595 women not on ART at the time of randomization, 302 were allocated to hormonal contraception, of whom 190 (63%) initiated DMPA and 112 (37%) initiated OCPs. Women starting IUD, OCPs, or DMPA were similar at baseline. Compared with women using the IUD, the adjusted hazard of death was not significantly increased among women using OCPs [1.24; 95% confidence interval (CI) 0.42-3.63] or DMPA (1.83; 95% CI 0.82-4.08). However, women using OCPs (adjusted hazard ratio (AHR) 1.69; 95% CI 1.09-2.64) or DMPA (AHR 1.56; 95% CI 1.08-2.26) trended toward an increased likelihood of becoming eligible for ART. Women exposed to OCPs (AHR 1.67; 95% CI 1.10-2.51) and DMPA (AHR 1.62; 95% CI 1.16-2.28) also had an increased hazard of meeting our composite disease progression outcome (death or becoming ART eligible) than women using the IUD. In this secondary analysis, exposure to OCPs or DMPA was associated with HIV disease progression among women not yet on ART. This finding, if confirmed elsewhere, would have global implications and requires urgent further investigation.

  12. APPLICATION OF AEM IN PROGRESSIVE COLLAPSE DYNAMICS ANALYSIS OF R.C. STRUCTURES

    Directory of Open Access Journals (Sweden)

    Osama El-Mahdy

    2018-01-01

    Full Text Available The Finite Element Method (FEM and the other numerical strategies are viably actualized in linear and non-linear analysis of structures. Recently, a new displacement based on Applied Element Method (AEM has been developed. It is applicable for static and dynamic for both linear and non-linear analysis of framed and continuum structures. In AEM, the structural member is partitioned into virtual elements connected through normal and shear springs representing stresses and strains of certain portion of structure. FEM assumes the material as continuous and can indicate highly stressed region of structure, however it is difficult to model separation of element unless crack location is known. The main advantage of AEM is that it can track the structural collapse behavior going through all phases of the application of loads. In the current research, the application of AEM is illustrated through a non-linear dynamic analysis. Progressive collapse simulation is conducted using Extreme Loading for Structures software (ELS, which follows the AEM. The experimental and analytical works carried by Park et al. [17 and 28] for 1/5 scaled 3 and 5 stories reinforced concrete structures are used for verification. Good matching between the experimental and numerical results has been obtained using ELS. Therefore, it can be confirmed that ELS is capable in simulating the structures’ behavior up to collapse. Furthermore, a study has been made to investigate the effect of considering the floor slabs on progressive collapse. The results show that considering slab in progressive collapse analysis of multistory buildings is important as neglecting the slabs’ contribution leads to incorrect simulation and uneconomic design.

  13. Peak and ceiling effects in final-product analysis of mastoidectomy performance

    DEFF Research Database (Denmark)

    West, N; Konge, L; Cayé-Thomasen, P

    2015-01-01

    BACKGROUND: Virtual reality surgical simulation of mastoidectomy is a promising training tool for novices. Final-product analysis for assessing novice mastoidectomy performance could be limited by a peak or ceiling effect. These may be countered by simulator-integrated tutoring. METHODS: Twenty......-two participants completed a single session of self-directed practice of the mastoidectomy procedure in a virtual reality simulator. Participants were randomised for additional simulator-integrated tutoring. Performances were assessed at 10-minute intervals using final-product analysis. RESULTS: In all, 45.5 per...... cent of participants peaked before the 60-minute time limit. None of the participants achieved the maximum score, suggesting a ceiling effect. The tutored group performed better than the non-tutored group but tutoring did not eliminate the peak or ceiling effects. CONCLUSION: Timing and adequate...

  14. Final Report: Meson Resonance Parametrizations for Partial-Wave Analysis at COMPASS

    CERN Document Server

    Dehn, Martin

    2014-01-01

    Within this summer student project, Monte Carlo data for diffractive scattering reactions of 190 GeV pions with 3 pions final states is simulated and analysed. Data generation and fitting is done with the root-based framework rpwa (root partial-wave analysis), a documentation of the setup and usage of this program is written. Effects on fit quality due to sample size and momentum dependent detector inefficiency are investigated.

  15. Final safety and hazards analysis for the Battelle LOCA simulation tests in the NRU reactor

    International Nuclear Information System (INIS)

    Axford, D.J.; Martin, I.C.; McAuley, S.J.

    1981-04-01

    This is the final safety and hazards report for the proposed Battelle LOCA simulation tests in NRU. A brief description of equipment test design and operating procedure precedes a safety analysis and hazards review of the project. The hazards review addresses potential equipment failures as well as potential for a metal/water reaction and evaluates the consequences. The operation of the tests as proposed does not present an unacceptable risk to the NRU Reactor, CRNL personnel or members of the public. (author)

  16. Analysis of Final Energy Demand by Sector in Malaysia using MAED Model

    International Nuclear Information System (INIS)

    Kumar, M.; Muhammed Zulfakar Mohd Zolkaffly; Alawiah Musa

    2011-01-01

    Energy supply security is important in ensuring a long term supply to fulfill the growing energy demand. This paper presents the use of IAEA energy planning tool, Model for Analysis of Energy Demand (MAED) to analyze, simulate and compare final energy demand by five different sectors in Malaysia under some assumptions, bounds and restrictions and the outcome can be used for planning of energy supply in future. (author)

  17. Progression In The Concepts Of Cognitive Sense Wireless Networks - An Analysis Report

    Science.gov (United States)

    Ajay, V. P.; Nesasudha, M.

    2017-10-01

    This paper illustrates the conception of networks, their primary goals (from day one to the present), the changes it had to endure to get to its present form and the developments which are in progress and in store for further standardization. The analysis gives more importance to the specifics of the Cognitive Radio Networks, which makes use of the dynamic spectrum access procedures, framed for better utilization of our available spectrum resources. The main conceptual difficulties and current research trends are also discussed in terms of real time implementation.

  18. Glaucoma progression detection by retinal nerve fiber layer measurement using scanning laser polarimetry: event and trend analysis.

    Science.gov (United States)

    Moon, Byung Gil; Sung, Kyung Rim; Cho, Jung Woo; Kang, Sung Yong; Yun, Sung-Cheol; Na, Jung Hwa; Lee, Youngrok; Kook, Michael S

    2012-06-01

    To evaluate the use of scanning laser polarimetry (SLP, GDx VCC) to measure the retinal nerve fiber layer (RNFL) thickness in order to evaluate the progression of glaucoma. Test-retest measurement variability was determined in 47 glaucomatous eyes. One eye each from 152 glaucomatous patients with at least 4 years of follow-up was enrolled. Visual field (VF) loss progression was determined by both event analysis (EA, Humphrey guided progression analysis) and trend analysis (TA, linear regression analysis of the visual field index). SLP progression was defined as a reduction of RNFL exceeding the predetermined repeatability coefficient in three consecutive exams, as compared to the baseline measure (EA). The slope of RNFL thickness change over time was determined by linear regression analysis (TA). Twenty-two eyes (14.5%) progressed according to the VF EA, 16 (10.5%) by VF TA, 37 (24.3%) by SLP EA and 19 (12.5%) by SLP TA. Agreement between VF and SLP progression was poor in both EA and TA (VF EA vs. SLP EA, k = 0.110; VF TA vs. SLP TA, k = 0.129). The mean (±standard deviation) progression rate of RNFL thickness as measured by SLP TA did not significantly differ between VF EA progressors and non-progressors (-0.224 ± 0.148 µm/yr vs. -0.218 ± 0.151 µm/yr, p = 0.874). SLP TA and EA showed similar levels of sensitivity when VF progression was considered as the reference standard. RNFL thickness as measurement by SLP was shown to be capable of detecting glaucoma progression. Both EA and TA of SLP showed poor agreement with VF outcomes in detecting glaucoma progression.

  19. Progress of studies on traditional chinese medicine based on complex network analysis

    Directory of Open Access Journals (Sweden)

    Qian-Ru Zhang

    2017-01-01

    Full Text Available Traditional Chinese medicine (TCM is a distinct medical system that deals with the life–health–disease–environment relationship using holistic, dynamic, and dialectical thinking. However, reductionism has often restricted the conventional studies on TCM, and these studies did not investigate the central concepts of TCM theory about the multiple relationships among life, health, disease, and environment. Complex network analysis describes a wide variety of complex systems in the real world, and it has the potential to bridge the gap between TCM and modern science owing to the holism of TCM theory. This article summarizes the current research involving TCM network analysis and highlights the computational tools and analysis methods involved in this research. Finally, to inspire a new approach, the article discussed the potential problems underlying the application of TCM network analysis.

  20. Educational Progress of Looked-After Children in England: A Study Using Group Trajectory Analysis.

    Science.gov (United States)

    Sutcliffe, Alastair G; Gardiner, Julian; Melhuish, Edward

    2017-09-01

    Looked-after children in local authority care are among the most disadvantaged, and measures of their well-being, including educational outcomes, are poorer than other children's. The study sample consisted of all children in England born in academic years 1993 to 1994 through 1997 to 1998 who were in local authority care at any point during the academic years 2005 to 2006 through 2012 to 2013 and for whom results of national tests in literacy and numeracy were available at ages 7, 11, and 16 ( N = 47 500). Group trajectory analysis of children's educational progress identified 5 trajectory groups: low achievement, late improvement, late decline, predominant, and high achievement. Being looked after earlier was associated with a higher probability of following a high achievement trajectory and a lower probability of following a late decline trajectory. For children first looked after between ages 7 and 16, having a longer total time looked after by age 16 was associated with a higher probability of following a high achievement trajectory. For children with poor outcomes at ages 7 and 11, being looked after by age 16 was associated with an increased chance of educational improvement by age 16. This study provides evidence that early entry into care can reduce the risk of poor educational outcomes. It also establishes group trajectory analysis as an effective method for analyzing the educational progress of looked-after children, with the particular strength that it allows factors associated with a late decline or improvement in educational progress to be identified. Copyright © 2017 by the American Academy of Pediatrics.

  1. ANSI/ASHRAE/IESNA Standard 90.1-2007 Final Determination Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Liu, Bing; Richman, Eric E.; Winiarski, David W.

    2011-05-01

    The United States (U.S.) Department of Energy (DOE) conducted a final quantitative analysis to assess whether buildings constructed according to the requirements of the American National Standards Institute (ANSI)/American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE)/Illuminating Engineering Society of North America (IESNA) Standard 90.1-2007 would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IESNA Standard 90.1-2004. The final analysis considered each of the 44 addenda to ANSI/ASHRAE/IESNA Standard 90.1-2004 that were included in ANSI/ASHRAE/IESNA Standard 90.1-2007. All 44 addenda processed by ASHRAE in the creation of Standard 90.1-2007 from Standard 90.1-2004 were reviewed by DOE, and their combined impact on a suite of 15 building prototype models in 15 ASHRAE climate zones was considered. Most addenda were deemed to have little quantifiable impact on building efficiency for the purpose of DOE’s final determination. However, out of the 44 addenda, 9 were preliminarily determined to have measureable and quantifiable impact.

  2. Plasma Exchange for Renal Vasculitis and Idiopathic Rapidly Progressive Glomerulonephritis: A Meta-analysis

    DEFF Research Database (Denmark)

    Walsh, Michael; Catapano, Fausta; Szpirt, Wladimir

    2010-01-01

    .9). LIMITATIONS:: Although the primary result was statistically significant, there is insufficient statistical information to reliably determine whether plasma exchange decreases the composite of end-stage renal disease or death. CONCLUSIONS:: Plasma exchange may decrease the composite end point of end......BACKGROUND:: Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis. STUDY DESIGN:: Systematic review and meta-analysis of articles identified from...... electronic databases, bibliographies, and studies identified by experts. Data were abstracted in parallel by 2 reviewers. SETTING & POPULATION:: Adults with idiopathic renal vasculitis or rapidly progressive glomerulonephritis. SELECTION CRITERIA FOR STUDIES:: Randomized controlled trials that compared...

  3. Research Progress on Pesticide Residue Analysis Techniques in Agro-products

    Directory of Open Access Journals (Sweden)

    HE Ze-ying

    2016-07-01

    Full Text Available There are constant occurrences of acute pesticide poisoning among consumers and pesticide residue violations in agro-products import/export trading. Pesticide residue analysis is the important way to protect the food safety and the interest of import/export enterprises. There has been a rapid development in pesticide residue analysis techniques in recent years. In this review, the research progress in the past five years were discussed in the respects of samples preparation and instrument determination. The application, modification and development of the QuEChERS method in samples preparation and the application of tandem mass spectrometry and high resolution mass spectrometry were reviewed. And the implications for the future of the field were discussed.

  4. Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression.

    Directory of Open Access Journals (Sweden)

    Christian J Gröger

    Full Text Available The epithelial to mesenchymal transition (EMT represents a crucial event during cancer progression and dissemination. EMT is the conversion of carcinoma cells from an epithelial to a mesenchymal phenotype that associates with a higher cell motility as well as enhanced chemoresistance and cancer stemness. Notably, EMT has been increasingly recognized as an early event of metastasis. Numerous gene expression studies (GES have been conducted to obtain transcriptome signatures and marker genes to understand the regulatory mechanisms underlying EMT. Yet, no meta-analysis considering the multitude of GES of EMT has been performed to comprehensively elaborate the core genes in this process. Here we report the meta-analysis of 18 independent and published GES of EMT which focused on different cell types and treatment modalities. Computational analysis revealed clustering of GES according to the type of treatment rather than to cell type. GES of EMT induced via transforming growth factor-β and tumor necrosis factor-α treatment yielded uniformly defined clusters while GES of models with alternative EMT induction clustered in a more complex fashion. In addition, we identified those up- and downregulated genes which were shared between the multitude of GES. This core gene list includes well known EMT markers as well as novel genes so far not described in this process. Furthermore, several genes of the EMT-core gene list significantly correlated with impaired pathological complete response in breast cancer patients. In conclusion, this meta-analysis provides a comprehensive survey of available EMT expression signatures and shows fundamental insights into the mechanisms that are governing carcinoma progression.

  5. Do peer-tutors perform better in examinations? An analysis of medical school final examination results.

    Science.gov (United States)

    Iwata, Kazuya; Furmedge, Daniel S; Sturrock, Alison; Gill, Deborah

    2014-07-01

    Peer-assisted learning (PAL) is recognised as an effective learning tool and its benefits are well documented in a range of educational settings. Learners find it enjoyable and their performances in assessments are comparable with those of students taught by faculty tutors. In addition, PAL tutors themselves report the development of improved clinical skills and confidence through tutoring. However, whether tutoring leads to actual improvement in performance has not been fully investigated. As high-achieving students are already en route to succeeding in final examinations, we wanted to examine whether participation in a peer-tutoring programme in itself leads to better final-year examination performance. We conducted a retrospective analysis of results on final-year written and clinical examinations at University College London Medical School during 2010-2012. Z-scores were calculated and the performances of PAL tutors and students who were not PAL tutors were compared using analysis of covariance (ancova). Year 4 examination results were used as indicators of previous academic attainment. Of the 1050 students who attempted the final examination, 172 were PAL tutors in the final year. Students who acted as PAL tutors outperformed students who did not in all examination components by 1-3%. Z-scores differed by approximately 0.2 and this was statistically significant, although the significance of this difference diminished when controlling for Year 4 results. Students who acted as PAL tutors who had scored in the top quartile in Year 4 examinations scored significantly better in a long-station objective structured clinical examination (LSO). Although students who acted as PAL tutors performed better than students who did not in final-year examinations, this difference was small and attributable to the students' background academic abilities. High-achieving students appear to be self-selecting as peer-tutors and their enhanced performance in LSOs may reflect their

  6. Rapid analysis of hay attributes using NIRS. Final report, Task II alfalfa supply system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-24

    This final report provides technical information on the development of a near infrared reflectance spectroscopy (NIRS) system for the analysis of alfalfa hay. The purpose of the system is to provide consistent quality for processing alfalfa stems for fuel and alfalfa leaf meal products for livestock feed. Project tasks were to: (1) develop an NIRS driven analytical system for analysis of alfalfa hay and processed alfalfa products; (2) assist in hiring a qualified NIRS technician and recommend changes in testing equipment necessary to provide accurate analysis; (3) calibrate the NIRS instrument for accurate analyses; and (4) develop prototype equipment and sampling procedures as a first step towards development of a totally automated sampling system that would rapidly sample and record incoming feedstock and outbound product. An accurate hay testing program was developed, along with calibration equations for analyzing alfalfa hay and sun-cured alfalfa pellets. A preliminary leaf steam calibration protocol was also developed. 7 refs., 11 figs., 10 tabs.

  7. WEXA: exergy analysis for increasing the efficiency of air/water heat pumps - Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gasser, L.; Wellig, B.; Hilfiker, K.

    2008-04-15

    This comprehensive final report for the Swiss Federal Office of Energy (SFOE) presents the results of a study at the made by the Engineering and Architecture department at the Lucerne University of Applied Sciences and Arts. The subject of the WEXA study (Waermepumpen-Exergie-Analyse - heat pump exergy analysis) is the analysis of the operation of air/water heat-pumps using exergy analysis methods. The basic thermodynamics of heating systems using heat-pumps is discussed. The exergy analyses and exergy balances for the various components and processes of an air/water heat-pump are presented and discussed. Comparisons are presented for heat-pumps with on/off and continuous control systems for their compressors and fans. The paper is concluded with a collection of appendices on the subject.

  8. Assessing Progress and Pitfalls of the Millennium Development Goals in Zimbabwe: A Critical Analysis

    Directory of Open Access Journals (Sweden)

    Shepherd Mutangabende

    2016-12-01

    Full Text Available Zimbabwe adopted the Millennium Development Goals (MDGs at their inception in 2000 and it has trends of its progress in its attempt to attain these MDGs as indicated in progress reports since 2004, 2010, 2012 and 2015. In these reports optimistic trends are chiefly found in MDG2 on universal primary education which is Zimbabwe’s pride in Africa, MDG3 regarding gender parity in schools and MDG6 on HIV and AIDS. The country continues to face its biggest challenges in attaining MDG1 which is eliminating extreme poverty and hunger and MDG5 which is increase nurturing mortality, whereas all the objectives under these goals are dubious that would be attained at the cut-off date. It was unfortunate that, the inception of the MDGs coincided with the deepening of socioeconomic, political and environmental crisis in the country which made it very difficult for Zimbabwe to accomplish all of its MDGs. The focal motive of this study was to check the progress, policies, programmes and strategies which were in place to promote the attainment of the MDGs from 2000-2015 and other strategies or policies in place to attain the SDGs 2016-2030. This paper recommended that there is need for institutionalisation of SDGs that is aligning them with Zimbabwe Agenda for Sustainable Socioeconomic Transformation (Zim-Asset cluster; for instance, value accumulation and beneficiation, nourishment security, poverty extermination, social services and strengthening partnership with all stakeholders. The research uses intensive secondary data analysis from various sources including government gazette, journal articles, e-books, and government website, reports, published and unpublished books.

  9. Mass spectrometric analysis of gingival crevicular fluid biomarkers can predict periodontal disease progression.

    Science.gov (United States)

    Ngo, L H; Darby, I B; Veith, P D; Locke, A G; Reynolds, E C

    2013-06-01

    Gingival crevicular fluid has been suggested as a possible source of biomarkers for periodontal disease progression. This paper describes a technique for the analysis of gingival crevicular fluid from individual sites using mass spectrometry. It explores the novel use of mass spectrometry to examine the relationship between the relative amounts of proteins and peptides in gingival crevicular fluid and their relationship with clinical indices and periodontal attachment loss in periodontal maintenance patients. The aim of this paper was to assess whether the mass spectrometric analysis of gingival crevicular fluid may allow for the site-specific prediction of periodontal disease progression. Forty-one periodontal maintenance subjects were followed over 12 mo, with clinical measurements taken at baseline and every 3 mo thereafter. Gingival crevicular fluid was collected from subjects at each visit and was analysed using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Samples were classified based upon pocket depth, modified gingival index (MGI), plaque index and attachment loss, and were analysed within these groups. A genetic algorithm was used to create a model based on pattern analysis to predict sites undergoing attachment loss. Three hundred and eighty-five gingival crevicular fluid samples were analysed. Twenty-five sites under observation in 14 patients exhibited attachment loss of > 2 mm over the 12-mo period. The clinical indices pocket depth, MGI, plaque levels and bleeding on probing served as poor discriminators of gingival crevicular fluid mass spectra. Models generated from the gingival crevicular fluid mass spectra could predict attachment loss at a site with a high specificity (97% recognition capability and 67% cross-validation). Gingival crevicular fluid mass spectra could be used to predict sites with attachment loss. The use of algorithm-generated models based on gingival crevicular fluid mass spectra may

  10. Final Report: Interphase Analysis and Control in Fiber Reinforced Thermoplastic Composites

    Energy Technology Data Exchange (ETDEWEB)

    Jon J. Kellar; William M. Cross; Lidvin Kjerengtroen

    2009-03-14

    This research program builds upon a multi-disciplinary effort in interphase analysis and control in thermoplastic matrix polymer matrix composites (PMC). The research investigates model systems deemed of interest by members of the Automotive Composites Consortium (ACC) as well as samples at the forefront of PMC process development (DRIFT and P4 technologies). Finally, the research investigates, based upon the fundamental understanding of the interphases created during the fabrication of thermoplastic PMCs, the role the interphase play in key bulk properties of interest to the automotive industry.

  11. Final Hazard Classification and Auditable Safety Analysis for the N Basin Segment

    International Nuclear Information System (INIS)

    Kloster, G.L.

    1998-08-01

    The purposes of this report are to serve as the auditable safety analysis (ASA) for the N Basin Segment, during surveillance and maintenance preceding decontamination and decommissioning; to determine and document the final hazard classification (FHC) for the N Basin Segment. The result of the ASA evaluation are: based on hazard analyses and the evaluation of accidents, no activity could credibly result in an unacceptable exposure to an individual; controls are identified that serve to protect worker health and safety. The results of the FHC evaluation are: potential exposure is much below 10 rem (0.46 rem), and the FHC for the N Basin Segment is Radiological

  12. ITER final design report, cost review and safety analysis (FDR) and relevant documents

    International Nuclear Information System (INIS)

    1999-01-01

    This volume contains the fourth major milestone report and documents associated with its acceptance, review and approval. This ITER Final Design Report, Cost Review and Safety Analysis was presented to the ITER Council at its 13th meeting in February 1998 and was approved at its extraordinary meeting on 25 June 1998. The contents include an outline of the ITER objectives, the ITER parameters and design overview as well as operating scenarios and plasma performance. Furthermore, design features, safety and environmental characteristics and schedule and cost estimates are given

  13. Progress in Analysis to Remote Sensed Thermal Abnormity with Fault Activity and Seismogenic Process

    Directory of Open Access Journals (Sweden)

    WU Lixin

    2017-10-01

    Full Text Available Research to the remote sensed thermal abnormity with fault activity and seismogenic process is a vital topic of the Earth observation and remote sensing application. It is presented that a systematic review on the international researches on the topic during the past 30 years, in the respects of remote sensing data applications, anomaly analysis methods, and mechanism understanding. Firstly, the outlines of remote sensing data applications are given including infrared brightness temperature, microwave brightness temperature, outgoing longwave radiation, and assimilated data from multiple earth observations. Secondly, three development phases are summarized as qualitative analysis based on visual interpretation, quantitative analysis based on image processing, and multi-parameter spatio-temporal correlation analysis. Thirdly, the theoretical hypotheses presented for the mechanism understanding are introduced including earth degassing, stress-induced heat, crustal rock battery conversion, latent heat release due to radon decay as well as multi-spheres coupling effect. Finally, three key directions of future research on this topic are proposed:anomaly recognizing by remote sensing monitoring and data analysis for typical tectonic activity areas; anomaly mechanism understanding based on earthquake-related earth system responses; spatio-temporal correlation analysis of air-based, space-based and ground-based stereoscopic observations.

  14. Visual and statistical analysis of {sup 18}F-FDG PET in primary progressive aphasia

    Energy Technology Data Exchange (ETDEWEB)

    Matias-Guiu, Jordi A.; Moreno-Ramos, Teresa; Garcia-Ramos, Rocio; Fernandez-Matarrubia, Marta; Oreja-Guevara, Celia; Matias-Guiu, Jorge [Hospital Clinico San Carlos, Department of Neurology, Madrid (Spain); Cabrera-Martin, Maria Nieves; Perez-Castejon, Maria Jesus; Rodriguez-Rey, Cristina; Ortega-Candil, Aida; Carreras, Jose Luis [San Carlos Health Research Institute (IdISSC) Complutense University of Madrid, Department of Nuclear Medicine, Hospital Clinico San Carlos, Madrid (Spain)

    2015-05-01

    Diagnosing progressive primary aphasia (PPA) and its variants is of great clinical importance, and fluorodeoxyglucose (FDG) positron emission tomography (PET) may be a useful diagnostic technique. The purpose of this study was to evaluate interobserver variability in the interpretation of FDG PET images in PPA as well as the diagnostic sensitivity and specificity of the technique. We also aimed to compare visual and statistical analyses of these images. There were 10 raters who analysed 44 FDG PET scans from 33 PPA patients and 11 controls. Five raters analysed the images visually, while the other five used maps created using Statistical Parametric Mapping software. Two spatial normalization procedures were performed: global mean normalization and cerebellar normalization. Clinical diagnosis was considered the gold standard. Inter-rater concordance was moderate for visual analysis (Fleiss' kappa 0.568) and substantial for statistical analysis (kappa 0.756-0.881). Agreement was good for all three variants of PPA except for the nonfluent/agrammatic variant studied with visual analysis. The sensitivity and specificity of each rater's diagnosis of PPA was high, averaging 87.8 and 89.9 % for visual analysis and 96.9 and 90.9 % for statistical analysis using global mean normalization, respectively. In cerebellar normalization, sensitivity was 88.9 % and specificity 100 %. FDG PET demonstrated high diagnostic accuracy for the diagnosis of PPA and its variants. Inter-rater concordance was higher for statistical analysis, especially for the nonfluent/agrammatic variant. These data support the use of FDG PET to evaluate patients with PPA and show that statistical analysis methods are particularly useful for identifying the nonfluent/agrammatic variant of PPA. (orig.)

  15. Visual and statistical analysis of 18F-FDG PET in primary progressive aphasia

    International Nuclear Information System (INIS)

    Matias-Guiu, Jordi A.; Moreno-Ramos, Teresa; Garcia-Ramos, Rocio; Fernandez-Matarrubia, Marta; Oreja-Guevara, Celia; Matias-Guiu, Jorge; Cabrera-Martin, Maria Nieves; Perez-Castejon, Maria Jesus; Rodriguez-Rey, Cristina; Ortega-Candil, Aida; Carreras, Jose Luis

    2015-01-01

    Diagnosing progressive primary aphasia (PPA) and its variants is of great clinical importance, and fluorodeoxyglucose (FDG) positron emission tomography (PET) may be a useful diagnostic technique. The purpose of this study was to evaluate interobserver variability in the interpretation of FDG PET images in PPA as well as the diagnostic sensitivity and specificity of the technique. We also aimed to compare visual and statistical analyses of these images. There were 10 raters who analysed 44 FDG PET scans from 33 PPA patients and 11 controls. Five raters analysed the images visually, while the other five used maps created using Statistical Parametric Mapping software. Two spatial normalization procedures were performed: global mean normalization and cerebellar normalization. Clinical diagnosis was considered the gold standard. Inter-rater concordance was moderate for visual analysis (Fleiss' kappa 0.568) and substantial for statistical analysis (kappa 0.756-0.881). Agreement was good for all three variants of PPA except for the nonfluent/agrammatic variant studied with visual analysis. The sensitivity and specificity of each rater's diagnosis of PPA was high, averaging 87.8 and 89.9 % for visual analysis and 96.9 and 90.9 % for statistical analysis using global mean normalization, respectively. In cerebellar normalization, sensitivity was 88.9 % and specificity 100 %. FDG PET demonstrated high diagnostic accuracy for the diagnosis of PPA and its variants. Inter-rater concordance was higher for statistical analysis, especially for the nonfluent/agrammatic variant. These data support the use of FDG PET to evaluate patients with PPA and show that statistical analysis methods are particularly useful for identifying the nonfluent/agrammatic variant of PPA. (orig.)

  16. Identifying Indicators of Progress in Thermal Spray Research Using Bibliometrics Analysis

    Science.gov (United States)

    Li, R.-T.; Khor, K. A.; Yu, L.-G.

    2016-12-01

    We investigated the research publications on thermal spray in the period of 1985-2015 using the data from Web of Science, Scopus and SciVal®. Bibliometrics analysis was employed to elucidate the country and institution distribution in various thermal spray research areas and to characterize the trends of topic change and technology progress. Results show that China, USA, Japan, Germany, India and France were the top countries in thermal spray research, and Xi'an Jiaotong University, Universite de Technologie Belfort-Montbeliard, Shanghai Institute of Ceramics, ETH Zurich, National Research Council of Canada, University of Limoges were among the top institutions that had high scholarly research output during 2005-2015. The terms of the titles, keywords and abstracts of the publications were analyzed by the Latent Dirichlet Allocation model and visually mapped using the VOSviewer software to reveal the progress of thermal spray technology. It is found that thermal barrier coating was consistently the main research area in thermal spray, and high-velocity oxy-fuel spray and cold spray developed rapidly in the last 10 years.

  17. Network analysis of breast cancer progression and reversal using a tree-evolving network algorithm.

    Directory of Open Access Journals (Sweden)

    Ankur P Parikh

    2014-07-01

    Full Text Available The HMT3522 progression series of human breast cells have been used to discover how tissue architecture, microenvironment and signaling molecules affect breast cell growth and behaviors. However, much remains to be elucidated about malignant and phenotypic reversion behaviors of the HMT3522-T4-2 cells of this series. We employed a "pan-cell-state" strategy, and analyzed jointly microarray profiles obtained from different state-specific cell populations from this progression and reversion model of the breast cells using a tree-lineage multi-network inference algorithm, Treegl. We found that different breast cell states contain distinct gene networks. The network specific to non-malignant HMT3522-S1 cells is dominated by genes involved in normal processes, whereas the T4-2-specific network is enriched with cancer-related genes. The networks specific to various conditions of the reverted T4-2 cells are enriched with pathways suggestive of compensatory effects, consistent with clinical data showing patient resistance to anticancer drugs. We validated the findings using an external dataset, and showed that aberrant expression values of certain hubs in the identified networks are associated with poor clinical outcomes. Thus, analysis of various reversion conditions (including non-reverted of HMT3522 cells using Treegl can be a good model system to study drug effects on breast cancer.

  18. Rate Dependent Multicontinuum Progressive Failure Analysis of Woven Fabric Composite Structures under Dynamic Impact

    Directory of Open Access Journals (Sweden)

    James Lua

    2004-01-01

    Full Text Available Marine composite materials typically exhibit significant rate dependent response characteristics when subjected to extreme dynamic loading conditions. In this work, a strain-rate dependent continuum damage model is incorporated with multicontinuum technology (MCT to predict damage and failure progression for composite material structures. MCT treats the constituents of a woven fabric composite as separate but linked continua, thereby allowing a designer to extract constituent stress/strain information in a structural analysis. The MCT algorithm and material damage model are numerically implemented with the explicit finite element code LS-DYNA3D via a user-defined material model (umat. The effects of the strain-rate hardening model are demonstrated through both simple single element analyses for woven fabric composites and also structural level impact simulations of a composite panel subjected to various impact conditions. Progressive damage at the constituent level is monitored throughout the loading. The results qualitatively illustrate the value of rate dependent material models for marine composite materials under extreme dynamic loading conditions.

  19. Proteomic analysis reveals novel proteins associated with progression and differentiation of colorectal carcinoma

    Directory of Open Access Journals (Sweden)

    Yi Gan

    2014-01-01

    Full Text Available Aim: The objective of this study is to characterize differential proteomic expression among well-differentiation and poor-differentiation colorectal carcinoma tissues and normal mucous epithelium. Materials and Methods: The study is based on quantitative 2-dimensional gel electrophoresis and analyzed by PDquest. Results: Excluding redundancies due to proteolysis and posttranslational modified isoforms of over 600 protein spots, 11 proteins were revealed as regulated with statistical variance being within the 95 th confidence level and were identified by peptide mass fingerprinting in matrix assisted laser desorption/ionization time-of-flight mass spectrometry. Progression-associated proteins belong to the functional complexes of tumorigenesis, proliferation, differentiation, metabolism, and the regulation of major histocompatibility complex processing and other functions. Partial but significant overlap was revealed with previous proteomics and transcriptomics studies in CRC. Among various differentiation stage of CRC tissues, we identified calreticulin precursor, MHC class I antigen (human leukocyte antigen A , glutathione S-transferase pi1, keratin 8, heat shock protein 27, tubulin beta chain, triosephosphate, fatty acid-binding protein, hemoglobin (deoxy mutant with val b 1 replaced by met (HBB, and zinc finger protein 312 (FEZF2. Conclusions: Their functional networks were analyzed by Ingenuity systems Ingenuity Pathways Analysis and revealed the potential roles as novel biomarkers for progression in various differentiation stages of CRC.

  20. [New progress on three-dimensional movement measurement analysis of human spine].

    Science.gov (United States)

    Qiu, Xiao-wen; He, Xi-jing; Huang, Si-hua; Liang, Bao-bao; Yu, Zi-rui

    2015-05-01

    Spinal biomechanics, especially the range of spine motion,has close connection with spinal surgery. The change of the range of motion (ROM) is an important indicator of diseases and injuries of spine, and the essential evaluating standards of effect of surgeries and therapies to spine. The analysis of ROM can be dated to the time of the invention of X-ray and even that before it. With the development of science and technology as well as the optimization of various types of calculation methods, diverse measuring methods have emerged, from imaging methods to non-imaging methods, from two-dimensional to three-dimensional, from measuring directly on the X-ray films to calculating automatically by computer. Analysis of ROM has made great progress, but there are some older methods cannot meet the needs of the times and disappear, some classical methods such as X-ray still have vitality. Combining different methods, three dimensions and more vivo spine research are the trend of analysis of ROM. And more and more researchers began to focus on vivo spine research. In this paper, the advantages and disadvantages of the methods utilized recently are presented through viewing recent literatures, providing reference and help for the movement analysis of spine.

  1. Seismic risk analysis for General Electric Plutonium Facility, Pleasanton, California. Final report, part II

    International Nuclear Information System (INIS)

    1980-01-01

    This report is the second of a two part study addressing the seismic risk or hazard of the special nuclear materials (SNM) facility of the General Electric Vallecitos Nuclear Center at Pleasanton, California. The Part I companion to this report, dated July 31, 1978, presented the seismic hazard at the site that resulted from exposure to earthquakes on the Calaveras, Hayward, San Andreas and, additionally, from smaller unassociated earthquakes that could not be attributed to these specific faults. However, while this study was in progress, certain additional geologic information became available that could be interpreted in terms of the existance of a nearby fault. Although substantial geologic investigations were subsequently deployed, the existance of this postulated fault, called the Verona Fault, remained very controversial. The purpose of the Part II study was to assume the existance of such a capable fault and, under this assumption, to examine the loads that the fault could impose on the SNM facility. This report first reviews the geologic setting with a focus on specifying sufficient geologic parameters to characterize the postulated fault. The report next presents the methodology used to calculate the vibratory ground motion hazard. Because of the complexity of the fault geometry, a slightly different methodology is used here compared to the Part I report. This section ends with the results of the calculation applied to the SNM facility. Finally, the report presents the methodology and results of the rupture hazard calculation

  2. Investigation of modern methods of probalistic sensitivity analysis of final repository performance assessment models (MOSEL)

    International Nuclear Information System (INIS)

    Spiessl, Sabine; Becker, Dirk-Alexander

    2017-06-01

    Sensitivity analysis is a mathematical means for analysing the sensitivities of a computational model to variations of its input parameters. Thus, it is a tool for managing parameter uncertainties. It is often performed probabilistically as global sensitivity analysis, running the model a large number of times with different parameter value combinations. Going along with the increase of computer capabilities, global sensitivity analysis has been a field of mathematical research for some decades. In the field of final repository modelling, probabilistic analysis is regarded a key element of a modern safety case. An appropriate uncertainty and sensitivity analysis can help identify parameters that need further dedicated research to reduce the overall uncertainty, generally leads to better system understanding and can thus contribute to building confidence in the models. The purpose of the project described here was to systematically investigate different numerical and graphical techniques of sensitivity analysis with typical repository models, which produce a distinctly right-skewed and tailed output distribution and can exhibit a highly nonlinear, non-monotonic or even non-continuous behaviour. For the investigations presented here, three test models were defined that describe generic, but typical repository systems. A number of numerical and graphical sensitivity analysis methods were selected for investigation and, in part, modified or adapted. Different sampling methods were applied to produce various parameter samples of different sizes and many individual runs with the test models were performed. The results were evaluated with the different methods of sensitivity analysis. On this basis the methods were compared and assessed. This report gives an overview of the background and the applied methods. The results obtained for three typical test models are presented and explained; conclusions in view of practical applications are drawn. At the end, a recommendation

  3. Investigation of modern methods of probalistic sensitivity analysis of final repository performance assessment models (MOSEL)

    Energy Technology Data Exchange (ETDEWEB)

    Spiessl, Sabine; Becker, Dirk-Alexander

    2017-06-15

    Sensitivity analysis is a mathematical means for analysing the sensitivities of a computational model to variations of its input parameters. Thus, it is a tool for managing parameter uncertainties. It is often performed probabilistically as global sensitivity analysis, running the model a large number of times with different parameter value combinations. Going along with the increase of computer capabilities, global sensitivity analysis has been a field of mathematical research for some decades. In the field of final repository modelling, probabilistic analysis is regarded a key element of a modern safety case. An appropriate uncertainty and sensitivity analysis can help identify parameters that need further dedicated research to reduce the overall uncertainty, generally leads to better system understanding and can thus contribute to building confidence in the models. The purpose of the project described here was to systematically investigate different numerical and graphical techniques of sensitivity analysis with typical repository models, which produce a distinctly right-skewed and tailed output distribution and can exhibit a highly nonlinear, non-monotonic or even non-continuous behaviour. For the investigations presented here, three test models were defined that describe generic, but typical repository systems. A number of numerical and graphical sensitivity analysis methods were selected for investigation and, in part, modified or adapted. Different sampling methods were applied to produce various parameter samples of different sizes and many individual runs with the test models were performed. The results were evaluated with the different methods of sensitivity analysis. On this basis the methods were compared and assessed. This report gives an overview of the background and the applied methods. The results obtained for three typical test models are presented and explained; conclusions in view of practical applications are drawn. At the end, a recommendation

  4. Guidelines for VCCT-Based Interlaminar Fatigue and Progressive Failure Finite Element Analysis

    Science.gov (United States)

    Deobald, Lyle R.; Mabson, Gerald E.; Engelstad, Steve; Prabhakar, M.; Gurvich, Mark; Seneviratne, Waruna; Perera, Shenal; O'Brien, T. Kevin; Murri, Gretchen; Ratcliffe, James; hide

    2017-01-01

    This document is intended to detail the theoretical basis, equations, references and data that are necessary to enhance the functionality of commercially available Finite Element codes, with the objective of having functionality better suited for the aerospace industry in the area of composite structural analysis. The specific area of focus will be improvements to composite interlaminar fatigue and progressive interlaminar failure. Suggestions are biased towards codes that perform interlaminar Linear Elastic Fracture Mechanics (LEFM) using Virtual Crack Closure Technique (VCCT)-based algorithms [1,2]. All aspects of the science associated with composite interlaminar crack growth are not fully developed and the codes developed to predict this mode of failure must be programmed with sufficient flexibility to accommodate new functional relationships as the science matures.

  5. Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans.

    Science.gov (United States)

    Li, Shan; Ganguli-Indra, Gitali; Indra, Arup K

    2016-05-01

    Lipidomics is the large-scale profiling and characterization of lipid species in a biological system using mass spectrometry. The skin barrier is mainly comprised of corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides, cholesterol and free fatty acids (FFA). Lipid compositions are altered in inflammatory skin disorders with disrupted skin barrier such as atopic dermatitis (AD). Here we discuss some of the recent applications of lipidomics in human skin biology and in inflammatory skin diseases such as AD, psoriasis and Netherton syndrome. We also review applications of lipidomics in human skin equivalent and in pre-clinical animal models of skin diseases to gain insight into the pathogenesis of the skin disease. Expert commentary: Skin lipidomics analysis could be a fast, reliable and noninvasive tool to characterize the skin lipid profile and to monitor the progression of inflammatory skin diseases such as AD.

  6. Damage analysis and fundamental studies. Quarterly progress report, October--December 1978

    Energy Technology Data Exchange (ETDEWEB)

    Zwilsky, Klaus M.

    1979-05-01

    This report is the fourth in a series of Quarterly Technical Progress Reports on Damage Analysis and Fundamental Studies (DAFS) which is one element of the Fusion Reactor Materials Program, conducted in support of the Magnetic Fusion Energy Program. This report is organized along topical lines in parallel to a Program Plan of the same title (to be published) so that activities and accomplishments may be followed readily relative to the Program Plan. Thus, the work of a given laboratory may appear throughout the report. Chapters 1 and 2 report topics which are generic to all of the DAFS Program: DAFS Task Group Activities and Irradiation Test Facilities, respectively. Chapters 3, 4, and 5 report the work that is specific to each of the subtasks around which the program is structured: A) Environmental Characterization, B) Damage Production, and C) Damage Microstructure Evolution and Mechanical Behavior.

  7. Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis.

    Science.gov (United States)

    Rohrer, Jonathan D; Rossor, Martin N; Warren, Jason D

    2010-08-17

    Despite recent work, the nosology of nonfluent primary progressive aphasia (PPA) remains unresolved. We describe a clinical and neurolinguistic cross-sectional analysis of a cohort of 24 patients with nonfluent PPA. Patients were initially classified based on analysis of spontaneous speech into 4 groups: apraxia of speech (AOS)/agrammatism (10 patients); AOS/no agrammatism (4 patients); no AOS/agrammatism (3 patients); no AOS/no agrammatism (7 patients). These groups were further characterized using a detailed neurolinguistic and neuropsychological battery. Parkinsonism was present in 3/10 patients in the AOS/agrammatism group. All patients in the no AOS/agrammatism group had mutations in the progranulin (GRN) gene, while 5/7 cases in the no AOS/no agrammatism group had CSF findings compatible with Alzheimer disease. The groups without AOS showed more severe neurolinguistic impairments for a given disease stage, and sentence comprehension, speech repetition, and reading were impaired in all groups. Prolonged word-finding pauses and impaired single word comprehension were salient features in the no AOS/agrammatism group. Additional impairments of executive function and praxis were present in both groups with agrammatism, and impaired episodic memory was a feature of the no AOS/no agrammatism group. PPA with AOS is aligned with the syndrome previously designated progressive nonfluent aphasia; agrammatism may emerge as the syndrome evolves, or alternatively, the pure AOS group may be pathophysiologically distinct. PPA without AOS resembles the syndrome designated logopenic/phonologic aphasia; however, there is evidence for a distinct subsyndrome of GRN-associated aphasia. The findings provide a rationale for further longitudinal studies with pathologic correlation.

  8. Progress in the neutronic core conversion (HEU-LEU) analysis of Ghana research reactor-1.

    Energy Technology Data Exchange (ETDEWEB)

    Anim-Sampong, S.; Maakuu, B. T.; Akaho, E. H. K.; Andam, A.; Liaw, J. J. R.; Matos, J. E.; Nuclear Engineering Division; Ghana Atomic Energy Commission; Kwame Nkrumah Univ. of Science and Technology

    2006-01-01

    The Ghana Research Reactor-1 (GHARR-1) is a commercial version of the Miniature Neutron Source Reactor (MNSR) and has operated at different power levels since its commissioning in March 1995. As required for all nuclear reactors, neutronic and thermal hydraulic analysis are being performed for the HEU-LEU core conversion studies of the Ghana Research Reactor-1 (GHARR-1) facility, which is a commercial version of the Miniature Neutron Source Reactor (MNSR). Stochastic Monte Carlo particle transport methods and tools (MCNP4c/MCNP5) were used to fine-tune a previously developed 3-D MCNP model of the GHARR-1 facility and perform neutronic analysis of the 90.2% HEU reference and candidate LEU (UO{sub 2}, U{sub 3}Si{sub 2}, U-9Mo) fresh cores with varying enrichments from 12.6%-19.75%. In this paper, the results of the progress made in the Monte Carlo neutronic analysis of the HEU reference and candidate LEU fuels are presented. In particular, a comparative performance assessment of the LEU with respect to neutron flux variations in the fission chamber and experimental irradiation channels are highlighted.

  9. ANALYSIS AND APPLICATION OF LIDAR WAVEFORM DATA USING A PROGRESSIVE WAVEFORM DECOMPOSITION METHOD

    Directory of Open Access Journals (Sweden)

    J. Zhu

    2012-09-01

    Full Text Available Due to rich information of a full waveform of airborne LiDAR (light detection and ranging data, the analysis of full waveform has been an active area in LiDAR application. It is possible to digitally sample and store the entire reflected waveform of small-footprint instead of only discrete point clouds. Decomposition of waveform data, a key step in waveform data analysis, can be categorized to two typical methods: 1 the Gaussian modelling method such as the Non-linear least-squares (NLS algorithm and the maximum likelihood estimation using the Exception Maximization (EM algorithm. 2 pulse detection method—Average Square Difference Function (ASDF. However, the Gaussian modelling methods strongly rely on initial parameters, whereas the ASDF omits the importance of parameter information of the waveform. In this paper, we proposed a fast algorithm—Progressive Waveform Decomposition (PWD method to extract local maxims and fit the echo with Gaussian function, and calculate other parameters from the raw waveform data. On the one hand, experiments are implemented to evaluate the PWD method and the results demonstrate its robustness and efficiency. On the other hand, with the PWD parametric analysis of the full-waveform instead of a 3D point cloud, some special applications are investigated afterward.

  10. Analysis and Application of LIDAR Waveform Data Using a Progressive Waveform Decomposition Method

    Science.gov (United States)

    Zhu, J.; Zhang, Z.; Hu, X.; Li, Z.

    2011-09-01

    Due to rich information of a full waveform of airborne LiDAR (light detection and ranging) data, the analysis of full waveform has been an active area in LiDAR application. It is possible to digitally sample and store the entire reflected waveform of small-footprint instead of only discrete point clouds. Decomposition of waveform data, a key step in waveform data analysis, can be categorized to two typical methods: 1) the Gaussian modelling method such as the Non-linear least-squares (NLS) algorithm and the maximum likelihood estimation using the Exception Maximization (EM) algorithm. 2) pulse detection method—Average Square Difference Function (ASDF). However, the Gaussian modelling methods strongly rely on initial parameters, whereas the ASDF omits the importance of parameter information of the waveform. In this paper, we proposed a fast algorithm—Progressive Waveform Decomposition (PWD) method to extract local maxims and fit the echo with Gaussian function, and calculate other parameters from the raw waveform data. On the one hand, experiments are implemented to evaluate the PWD method and the results demonstrate its robustness and efficiency. On the other hand, with the PWD parametric analysis of the full-waveform instead of a 3D point cloud, some special applications are investigated afterward.

  11. Reliability of steam-turbine rotors. Task 1. Lifetime prediction analysis system. Final report

    International Nuclear Information System (INIS)

    Nair, P.K.; Pennick, H.G.; Peters, J.E.; Wells, C.H.

    1982-12-01

    Task 1 of RP 502, Reliability of Steam Turbine Rotors, resulted in the development of a computerized lifetime prediction analysis system (STRAP) for the automatic evaluation of rotor integrity based upon the results of a boresonic examination of near-bore defects. Concurrently an advanced boresonic examination system (TREES), designed to acquire data automatically for lifetime analysis, was developed and delivered to the maintenance shop of a major utility. This system and a semi-automated, state-of-the-art system (BUCS) were evaluated on two retired rotors as part of the Task 2 effort. A modified nonproprietary version of STRAP, called SAFER, is now available for rotor lifetime prediction analysis. STRAP and SAFER share a common fracture analysis postprocessor for rapid evaluation of either conventional boresonic amplitude data or TREES cell data. The final version of this postprocessor contains general stress intensity correlations for elliptical cracks in a radial stress gradient and provision for elastic-plastic instability of the ligament between an imbedded crack and the bore surface. Both linear elastic and ligament rupture models were developed for rapid analysis of linkup within three-dimensional clusters of defects. Bore stress-rupture criteria are included, but a creep-fatigue crack growth data base is not available. Physical and mechanical properties of air-melt 1CrMoV forgings are built into the program; however, only bounding values of fracture toughness versus temperature are available. Owing to the lack of data regarding the probability of flaw detection for the boresonic systems and of quantitative verification of the flaw linkup analysis, automatic evlauation of boresonic results is not recommended, and the lifetime prediction system is currently restricted to conservative, deterministic analysis of specified flaw geometries

  12. Selected Area Fishery Evaluation Project Economic Analysis Study Final Report, Final Draft Revision 4: November 10, 2006.

    Energy Technology Data Exchange (ETDEWEB)

    Bonneville Power Administration; Washington Department of Fish and Wildlife; Oregon Department of Fish and Wildlife

    2006-11-01

    The purpose of this Study is to provide an economic review of current and proposed changes to the Select Area Fishery Evaluation Project (SAFE or Project). The Study results are the information requested in comments made on the Project by a joint review dated March 2005 by the Northwest Power and Conservation Council (NPCC) Independent Scientific Review Panel (ISRP) and Independent Economic Analysis Board (IEAB). North et al. (2006) addressed technical questions about operations and plans, and this report contains the response information for comments concerning Project economics. This report can be considered an economic feasibility review meeting guidelines for cost-effective analysis developed by the IEAB (2003). It also contains other economic measurement descriptions to illustrate the economic effects of SAFE. The SAFE is an expansion of a hatchery project (locally called the Clatsop Economic Development Council Fisheries Project or CEDC) started in 1977 that released an early run coho (COH) stock into the Youngs River. The Youngs River entrance to the Columbia River at River Mile 12 is called Youngs Bay, which is located near Astoria, Oregon. The purpose of the hatchery project was to provide increased fishing opportunities for the in-river commercial fishing gillnet fleet. Instead of just releasing fish at the hatchery, a small scale net pen acclimation project in Youngs Bay was tried in 1987. Hirose et al. (1998) found that 1991-1992 COH broodstock over-wintered at the net pens had double the smolt-to-adult return rate (SAR) of traditional hatchery release, less than one percent stray rates, and 99 percent fishery harvests. It was surmised that smolts from other Columbia River hatcheries could be hauled to the net pens for acclimation and release to take advantage of the SAR's and fishing rates. Proposals were tendered to Bonneville Power Administration (BPA) and other agencies to fund the expansion for using other hatcheries smolts and other off

  13. Vehicle technologies heavy vehicle program : FY 2008 benefits analysis, methodology and results --- final report.

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M.; Energy Systems; TA Engineering

    2008-02-29

    This report describes the approach to estimating the benefits and analysis results for the Heavy Vehicle Technologies activities of the Vehicle Technologies (VT) Program of EERE. The scope of the effort includes: (1) Characterizing baseline and advanced technology vehicles for Class 3-6 and Class 7 and 8 trucks, (2) Identifying technology goals associated with the DOE EERE programs, (3) Estimating the market potential of technologies that improve fuel efficiency and/or use alternative fuels, and (4) Determining the petroleum and greenhouse gas emissions reductions associated with the advanced technologies. In FY 08 the Heavy Vehicles program continued its involvement with various sources of energy loss as compared to focusing more narrowly on engine efficiency and alternative fuels. These changes are the result of a planning effort that first occurred during FY 04 and was updated in the past year. (Ref. 1) This narrative describes characteristics of the heavy truck market as they relate to the analysis, a description of the analysis methodology (including a discussion of the models used to estimate market potential and benefits), and a presentation of the benefits estimated as a result of the adoption of the advanced technologies. The market penetrations are used as part of the EERE-wide integrated analysis to provide final benefit estimates reported in the FY08 Budget Request. The energy savings models are utilized by the VT program for internal project management purposes.

  14. Analysis of temperatures during the firing bricks and final properties solid

    Directory of Open Access Journals (Sweden)

    Gustavo Guerrero Gómez

    2017-01-01

    Full Text Available Context: Since the estructural behavior of the walls in a building directly depends on the properties of the blocks used, these properties are very important. In particular, the final properties of a ceramic block (often used in masonry depend on the cooking temperature of the pulp. Objective: The purpose of this research is to determine the relationship between the final properties of a ceramic block and the temperature at which it was cooked. Additionally, it is wroth considering how quickly these temperatures vary in the kiln. Method: In first place, a system based on Labview was used to record the temperatures in the oven. In second place, it was considered the temperature increasing rate according to the ideal curve for baking blocks, which was classified inside the oven. In third place, samples of the product were taken according to the technical norms NTC 4017 and NTC 4205 in order to determine the properties of the block. Results: According to the samples, we determined: the Initial absorption of water (TIA, the absorption rate at 24 hours of immersion, the compressive strength, and the Modulus of Rupture (MR. Additionally, applying a multiple linear regression analysis, it was found a relationship between the TIA, the temperature increase rate, and the MR. Conclusions: From the results in the research, it is possible to conclude that: blocks baked at more than 1000 °C have the highest modulus of rupture (1.54 MPa; however, it was found that blocks baked at lower temperature presented the highest initial absorption rate (0.37 gr/cm2/min and the best compressive strength (7.28 MPa. Finally, since the temperature and time are not controlled during the baking process, it is difficult for properties to be the most suitable.

  15. Using root cause analysis to promote critical thinking in final year Bachelor of Midwifery students.

    Science.gov (United States)

    Carter, Amanda G; Sidebotham, Mary; Creedy, Debra K; Fenwick, Jennifer; Gamble, Jenny

    2014-06-01

    Midwives require well developed critical thinking to practice autonomously. However, multiple factors impinge on students' deep learning in the clinical context. Analysis of actual case scenarios using root cause analysis may foster students' critical thinking and application of 'best practice' principles in complex clinical situations. To examine the effectiveness of an innovative teaching strategy involving root cause analysis to develop students' perceptions of their critical thinking abilities. A descriptive, mixed methods design was used. Final 3rd year undergraduate midwifery students (n=22) worked in teams to complete and present an assessment item based on root cause analysis. The cases were adapted from coroners' reports. After graduation, 17 (77%) students evaluated the course using a standard university assessment tool. In addition 12 (54%) students provided specific feedback on the teaching strategy using a 16-item survey tool based on the domain concepts of Educational Acceptability, Educational Impact, and Preparation for Practice. Survey responses were on a 5-point Likert scale and analysed using descriptive statistics. Open-ended responses were analysed using content analysis. The majority of students perceived the course and this teaching strategy positively. The domain mean scores were high for Educational Acceptability (mean=4.3, SD=.49) and Educational Impact (mean=4.19, SD=.75) but slightly lower for Preparation for Practice (mean=3.7, SD=.77). Overall student responses to each item were positive with no item mean less than 3.42. Students found the root cause analysis challenging and time consuming but reported development of critical thinking skills about the complexity of practice, clinical governance and risk management principles. Analysing complex real life clinical cases to determine a root cause enhanced midwifery students' perceptions of their critical thinking. Teaching and assessment strategies to promote critical thinking need to be

  16. A three-dimensional finite element analysis of the osseointegration progression in the human mandible

    Science.gov (United States)

    Esmail, Enas; Hassan, Noha; Kadah, Yasser

    2010-02-01

    In this study, three-dimensional (3D) finite element analysis was used to model the effect of the peri-implant bone geometry and thickness on the biomechanical behavior of a dental implant/supporting bone system. The 3D finite element model of the jaw bone, cancellous and cortical, was developed based on computerized tomography (CT) scan technology while the dental implant model was created based on a commercially available implant design. Two models, cylindrical and threaded, representing the peri-implant bone region were simulated. In addition, various thicknesses (0.1 mm, 0.3 mm, 0.5 mm) of the peri-implant bone region were modeled to account for the misalingnment during the drilling process. Different biomechanical properties of the peri-implant bone region were used to simulate the progression of the osseointegration process with time. Four stages of osseointegration were modeled to mimic different phases of tissue healing of the peri- implant region starting with soft connective tissue and ending with complete bone maturation. For the realistic threaded model of the peri-implant bone region, the maximum von Mises stress and displacement in the dental implant and jaw bone were higher than those computed for the simple cylindrical peri-implant bone region model. The average von Mises stress and displacement in the dental implant and the jaw bone decreased as the oseeointegration progressed with time for all thicknesses of the peri-implant bone region. On the other hand, the maximum absolute vertical displacement of the dental implant increased as the drilled thickness of the peri-implant bone region increased.

  17. Multi-task linear programming discriminant analysis for the identification of progressive MCI individuals.

    Directory of Open Access Journals (Sweden)

    Guan Yu

    Full Text Available Accurately identifying mild cognitive impairment (MCI individuals who will progress to Alzheimer's disease (AD is very important for making early interventions. Many classification methods focus on integrating multiple imaging modalities such as magnetic resonance imaging (MRI and fluorodeoxyglucose positron emission tomography (FDG-PET. However, the main challenge for MCI classification using multiple imaging modalities is the existence of a lot of missing data in many subjects. For example, in the Alzheimer's Disease Neuroimaging Initiative (ADNI study, almost half of the subjects do not have PET images. In this paper, we propose a new and flexible binary classification method, namely Multi-task Linear Programming Discriminant (MLPD analysis, for the incomplete multi-source feature learning. Specifically, we decompose the classification problem into different classification tasks, i.e., one for each combination of available data sources. To solve all different classification tasks jointly, our proposed MLPD method links them together by constraining them to achieve the similar estimated mean difference between the two classes (under classification for those shared features. Compared with the state-of-the-art incomplete Multi-Source Feature (iMSF learning method, instead of constraining different classification tasks to choose a common feature subset for those shared features, MLPD can flexibly and adaptively choose different feature subsets for different classification tasks. Furthermore, our proposed MLPD method can be efficiently implemented by linear programming. To validate our MLPD method, we perform experiments on the ADNI baseline dataset with the incomplete MRI and PET images from 167 progressive MCI (pMCI subjects and 226 stable MCI (sMCI subjects. We further compared our method with the iMSF method (using incomplete MRI and PET images and also the single-task classification method (using only MRI or only subjects with both MRI and

  18. Progress in Addressing DNFSB Recommendation 2002-1 Issues: Improving Accident Analysis Software Applications

    International Nuclear Information System (INIS)

    VINCENT, ANDREW

    2005-01-01

    Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 2002-1 (''Quality Assurance for Safety-Related Software'') identified a number of quality assurance issues on the use of software in Department of Energy (DOE) facilities for analyzing hazards, and designing and operating controls to prevent or mitigate potential accidents. Over the last year, DOE has begun several processes and programs as part of the Implementation Plan commitments, and in particular, has made significant progress in addressing several sets of issues particularly important in the application of software for performing hazard and accident analysis. The work discussed here demonstrates that through these actions, Software Quality Assurance (SQA) guidance and software tools are available that can be used to improve resulting safety analysis. Specifically, five of the primary actions corresponding to the commitments made in the Implementation Plan to Recommendation 2002-1 are identified and discussed in this paper. Included are the web-based DOE SQA Knowledge Portal and the Central Registry, guidance and gap analysis reports, electronic bulletin board and discussion forum, and a DOE safety software guide. These SQA products can benefit DOE safety contractors in the development of hazard and accident analysis by precluding inappropriate software applications and utilizing best practices when incorporating software results to safety basis documentation. The improvement actions discussed here mark a beginning to establishing stronger, standard-compliant programs, practices, and processes in SQA among safety software users, managers, and reviewers throughout the DOE Complex. Additional effort is needed, however, particularly in: (1) processes to add new software applications to the DOE Safety Software Toolbox; (2) improving the effectiveness of software issue communication; and (3) promoting a safety software quality assurance culture

  19. Analysis of factors affecting local tumor progression of colorectal cancer liver metastasis after radiofrequency ablation

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Seong Hee; Cho, Yun Ku; Choi, Seung A; Kim, Mi Young; Lee, Ho Suk [Veterans Health Service Medical Center, Seoul (Korea, Republic of)

    2017-03-15

    The purpose of this study was to evaluate the independent predictive factors for local tumor progression (LTP) of colorectal liver metastasis (CRLM) after radiofrequency ablation (RFA). Patients with CRLM were included in the analysis if nodules were up to five in number, each nodule was ≤ 5 cm, and RFA was performed in our center from January 2006 to December 2015. Univariate and multivariate analyses to identify the predictors of LTP were performed by using a Cox proportional hazard model. Overall, 58 tumors from 38 patients were included in this study. LTP occurred in 14 tumors from 9 patients. The overall 1- and 3-year LTP rates were 23.5% and 29.4%, respectively. Multivariate analysis showed that tumor size > 2 cm and insufficient ablative margin were two independently significant adverse prognostic factors for LTP (p = 0.045 and 0.022, respectively). The 3-year LTP rates for 33 and 25 tumors with and without sufficient ablative margin were 4.5% and 61.2%, respectively. The difference was statistically significant (p < 0.001). The difference in the 3-year LTP rates according to the tumor size was not statistically significant (p = 0.791). Insufficient ablative margin seems to be the most potent predictor of LTP after RFA of CRLM.

  20. Damage analysis and fundamental studies. Quarterly progress report, January--March 1978

    Energy Technology Data Exchange (ETDEWEB)

    Zwilsky, Klaus M.

    1978-08-01

    This report is the first in a series of Quarterly Technical Progress Reports on ''Damage Analysis and Fundamental Studies'' (DAFS), which is one element of the Fusion Reactor Materials Program, conducted in support of the Magnetic Fusion Energy Program of the U.S. Department of Energy. The DAFS program element is a national effort composed of contributions from a number of National Laboratories and other government laboratories, universities, and industrial laboratories. It was organized by the Materials and Radiation Effects Branch, Office of Fusion Energy, DOE, and a Task Group on Damage Analysis and Fundamental Studies which operates under the auspices of that Branch. The purpose of this series of reports is to provide a working technical record of that effort for the use of the program participants, for the fusion energy program in general, and for the Department of Energy. This report is organized along topical lines in parallel to a Program Plan of the same title (to be published) so that activities and accomplishments may be followed readily relative to that Program Plan. Thus, the work of a given laboratory may appear throughout the report. Chapters 1 and 2 report topics which are generic to all of the DAFS Program: DAFS Task Group Activities and Irradiation Test Facilities, respectively. Chapters 3, 4, and 5 report the work that is specific to each of the subtasks around which the program is structured: A. Environmental Characterization, B. Damage Production, and C. Damage Microstructure Evolution and Mechanical Behavior.

  1. Automatic progressive damage detection of rotor bar in induction motor using vibration analysis and multiple classifiers

    Energy Technology Data Exchange (ETDEWEB)

    Cruz-Vega, Israel; Rangel-Magdaleno, Jose; Ramirez-Cortes, Juan; Peregrina-Barreto, Hayde [Santa María Tonantzintla, Puebla (Mexico)

    2017-06-15

    There is an increased interest in developing reliable condition monitoring and fault diagnosis systems of machines like induction motors; such interest is not only in the final phase of the failure but also at early stages. In this paper, several levels of damage of rotor bars under different load conditions are identified by means of vibration signals. The importance of this work relies on a simple but effective automatic detection algorithm of the damage before a break occurs. The feature extraction is based on discrete wavelet analysis and auto- correlation process. Then, the automatic classification of the fault degree is carried out by a binary classification tree. In each node, com- paring the learned levels of the breaking off correctly identifies the fault degree. The best results of classification are obtained employing computational intelligence techniques like support vector machines, multilayer perceptron, and the k-NN algorithm, with a proper selection of their optimal parameters.

  2. Automatic progressive damage detection of rotor bar in induction motor using vibration analysis and multiple classifiers

    International Nuclear Information System (INIS)

    Cruz-Vega, Israel; Rangel-Magdaleno, Jose; Ramirez-Cortes, Juan; Peregrina-Barreto, Hayde

    2017-01-01

    There is an increased interest in developing reliable condition monitoring and fault diagnosis systems of machines like induction motors; such interest is not only in the final phase of the failure but also at early stages. In this paper, several levels of damage of rotor bars under different load conditions are identified by means of vibration signals. The importance of this work relies on a simple but effective automatic detection algorithm of the damage before a break occurs. The feature extraction is based on discrete wavelet analysis and auto- correlation process. Then, the automatic classification of the fault degree is carried out by a binary classification tree. In each node, com- paring the learned levels of the breaking off correctly identifies the fault degree. The best results of classification are obtained employing computational intelligence techniques like support vector machines, multilayer perceptron, and the k-NN algorithm, with a proper selection of their optimal parameters.

  3. Barometric pressure transient testing applications at the Nevada Test Site. Nuclear chimney analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, J.M.

    1985-12-01

    Investigations of barometric pressure testing of NTS nuclear chimneys were reviewed. This review includes the models used in the interpretation, methods of analysis, and results. Analytic and semi-analytic models were presented and applied to both historical data and new data taken for this current project. An interpretation technique based on non-linear least squares methods was used to analyze this data in terms of historic and more recent chimney models. Finally, a detailed discussion of radioactive gas transport due to surface barometric pressure fluctuations was presented. This mechanism of transport, referred to as ''barometric pumping,'' is presented in terms of conditions likely to be encountered at the NTS. The report concludes with a discussion of the current understanding of gas flow properties in the alluvial and volcanic areas of the NTS, and suggestions for future efforts directed toward increasing this understanding are presented.

  4. Final safety analysis report for the Galileo Mission: Volume 2, Book 2: Accident model document: Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1988-12-15

    This section of the Accident Model Document (AMD) presents the appendices which describe the various analyses that have been conducted for use in the Galileo Final Safety Analysis Report II, Volume II. Included in these appendices are the approaches, techniques, conditions and assumptions used in the development of the analytical models plus the detailed results of the analyses. Also included in these appendices are summaries of the accidents and their associated probabilities and environment models taken from the Shuttle Data Book (NSTS-08116), plus summaries of the several segments of the recent GPHS safety test program. The information presented in these appendices is used in Section 3.0 of the AMD to develop the Failure/Abort Sequence Trees (FASTs) and to determine the fuel releases (source terms) resulting from the potential Space Shuttle/IUS accidents throughout the missions.

  5. Final hazard classification and auditable safety analysis for the N basin segment

    International Nuclear Information System (INIS)

    Kloster, G.; Smith, R.I.; Larson, A.R.; Duncan, G.M.

    1996-12-01

    The purpose of this report is to provide the following: To serve as the auditable safety analysis (ASA) for the N Basin Segment, including both the quiescent state and planned intrusive activities. The ASA is developed through the realistic evaluation of potential hazards that envelope the threat to personnel. The ASA also includes the specification of the programmatic, baseline, and activity- specific controls that are necessary for the protection of workers. To determine and document the final hazard classification (FHC) for the N Basin Segment. The FHC is developed through the use of bounding accident analyses that envelope the potential exposures to personnel. The FHC also includes the specification of the special controls that are necessary to remain within the envelope of those accident analyses

  6. Barometric pressure transient testing applications at the Nevada Test Site. Nuclear chimney analysis. Final report

    International Nuclear Information System (INIS)

    Hanson, J.M.

    1985-12-01

    Investigations of barometric pressure testing of NTS nuclear chimneys were reviewed. This review includes the models used in the interpretation, methods of analysis, and results. Analytic and semi-analytic models were presented and applied to both historical data and new data taken for this current project. An interpretation technique based on non-linear least squares methods was used to analyze this data in terms of historic and more recent chimney models. Finally, a detailed discussion of radioactive gas transport due to surface barometric pressure fluctuations was presented. This mechanism of transport, referred to as ''barometric pumping,'' is presented in terms of conditions likely to be encountered at the NTS. The report concludes with a discussion of the current understanding of gas flow properties in the alluvial and volcanic areas of the NTS, and suggestions for future efforts directed toward increasing this understanding are presented

  7. Respect in final-year student nurse–patient encounters – an interpretative phenomenological analysis

    Science.gov (United States)

    Clucas, Claudine; Chapman, Hazel M.

    2014-01-01

    Very little is known regarding health-care professionals' understanding and experiences of respect towards patients. The study aimed to explore student nurses' understanding and experiences of respect in their encounters with patients. Semi-structured interviews were conducted with eight final-year student nurses with practice placements across different health-care trusts in the UK. Transcripts were analysed using interpretative phenomenological analysis (IPA). Three super-ordinate themes were identified: understanding of what it means to show respect, negotiating role expectations and personal attitudes in practice, and barriers related to the performance of the nursing role. The factors identified should be investigated further and addressed as they are likely to influence patients' experiences of feeling respected in nurse–patient interactions and subsequently their well-being and health-related behaviours. PMID:25750810

  8. Regulatory analysis for final rule on nuclear power plant license renewal

    International Nuclear Information System (INIS)

    1991-12-01

    This regulatory analysis provides the supporting information for the final rule (10 CFR Part 54) that defines the Nuclear Regulatory Commission's requirements for renewing the operating licenses of commercial nuclear power plants. A set of four specific alternatives for the safety review of license renewal applications is defined and evaluated. These are: Alternative A-current licensing basis; Alternative B-extension of Alternative A to require assessment and managing of aging; Alternative C -- extension of Alternative B to require assessment of design differences against selected new-plant standards using probabilistic risk assessment; and Alternative D -- extension of Alternative B to require compliance with all new-plant standards. A quantitative comparison of the four alternatives in terms of impact-to-value ratio is presented, and Alternative B is the most cost-beneficial safety review alternative

  9. Cost analysis for final disposal of double-shell tank waste

    International Nuclear Information System (INIS)

    Seifert, T.W.; Markillie, K.D.

    1996-01-01

    The Cost Analysis For Final Disposal of Double-Shell Tank Waste provides the Department of Energy (DOE) and DOE contractors with a better understanding of costs associated with the transfer, storage, and treatment of liquid mixed wasted within the Double-Shell Tank System (DST). In order to evaluate waste minimization/pollution prevention ideas, it is necessary to have reliable cost data that can be used in cost/benefit analyses; preparation of funding requests and/or proposals; and provide a way for prioritizing and allocating limited resources. This cost per gallon rate will be used by DST waste generators to assess the feasibility of Pollution Prevention Opportunity Assessments (P20A) and to determine the cost avoidances or savings associated with the implementation of those P20As

  10. Volumetric analysis of the cerebellum in patients with progressive supranuclear palsy.

    Science.gov (United States)

    Lee, Y; Lee, D K; Lee, J M; Chung, S J; Lee, J J; Sohn, Y H; Lee, P H

    2017-01-01

    Although early cerebellar symptoms are one of the exclusive criteria in the diagnosis of progressive supranuclear palsy (PSP), cerebellar involvement in PSP is evident both clinically and pathologically. However, structural analysis focusing on the cerebellum has not been previously studied in patients with PSP. We aimed to evaluate cerebellar involvement in PSP using a magnetic resonance imaging-based segmental volumetric analysis. We retrospectively enrolled 48 patients with PSP composed of 25 patients with PSP-Richardson's syndrome (RS) and 23 patients with pure akinesia with gait freezing, 39 patients with Parkinson's disease (PD) and 34 healthy controls. Data on both the whole and segmented cerebellar volumes were analyzed using a fully automated procedure. A general linear model showed that whole cerebellar volume in patients with PSP was significantly smaller compared with that of patients with PD or controls after controlling for age, sex and intracranial volume (P = 0.34). In addition, patients with PSP exhibited decreased regional volume in the crus I, lobule VIIIa and lobule VIIIb, which play roles as secondary representations of motor tasks, compared with patients with PD or controls. In subgroup analysis of PSP, volume loss in the whole and segmental cerebellum was more pronounced in patients with PSP-RS than in those with pure akinesia with gait freezing, PD or control subjects. These data demonstrate that cerebellar atrophy is evident in patients with PSP and is especially prominent in the PSP-RS group. These findings increase understanding of the clinicopathological basis of cerebellar involvement in PSP. © 2016 EAN.

  11. Embedded Domain-Specific Language and Runtime System for Progressive Spatiotemporal Data Analysis and Visualization

    Science.gov (United States)

    Christensen, C.; Liu, S.; Scorzelli, G.; Lee, J. W.; Bremer, P. T.; Pascucci, V.

    2016-12-01

    As our ability to generate large and complex climate simulation datasets grows, accessing and processing these massive data collections is increasingly becoming the primary bottleneck in scientific analysis. Challenges include retrieving, converting, resampling and combining remote and often disparately located data ensembles with only limited support from existing tools. In particular, existing solutions predominantly rely on extensive data transfers or large-scale remote computing resources, both of which are inherently offline processes with long delays and substantial repercussions for any mistakes. Such workflows severely limit the flexible exploration and rapid evaluation of new hypotheses that are crucial to the scientific process and thereby impede scientific discovery. Here we present an embedded domain-specific language (EDSL) specifically designed for the interactive exploration of large-scale, remote data ensembles. Our EDSL allows users to express a wide range of data analysis operations in a simple and abstract manner. An underlying runtime system transparently resolves issues such as remote data access and resampling while at the same time maintaining interactivity through progressive and interruptible computation. This allows, for the first time, interactive remote exploration of massive data sets such as the 7km NASA GEOS-5 Nature Run simulation, which previously have only been analyzed offline or at reduced resolution. The significant time-savings and convenience provided by the framework enables scientists to focus on core analysis tasks rather than data management, and encourages them to experiment more. One of the advantages of this freedom to interactively perform various analyses has already been demonstrated by the discovery of a serious error in a widely-used public dataset.

  12. ANSI/ASHRAE/IES Standard 90.1-2010 Final Determination Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Liu, Bing

    2011-10-31

    The U.S. Department of Energy (DOE) conducted a final quantitative analysis to assess whether buildings constructed according to the requirements of the American National Standards Institute (ANSI)/American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE)/Illuminating Engineering Society of North America (IESNA) Standard 90.1-2010 (ASHRAE Standard 90.1-2010, Standard 90.1-2010, or 2010 edition) would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IESNA Standard 90.1-2007(ASHRAE Standard 90.1-2007, Standard 90.1-2007, or 2007 edition). The final analysis considered each of the 109 addenda to ASHRAE Standard 90.1-2007 that were included in ASHRAE Standard 90.1-2010. All 109 addenda processed by ASHRAE in the creation of Standard 90.1-2010 from Standard 90.1-2007 were reviewed by DOE, and their combined impact on a suite of 16 building prototype models in 15 ASHRAE climate zones was considered. Most addenda were deemed to have little quantifiable impact on building efficiency for the purpose of DOE's final determination. However, out of the 109 addenda, 34 were preliminarily determined to have a measureable and quantifiable impact. A suite of 240 computer energy simulations for building prototypes complying with ASHRAE 90.1-2007 was developed. These prototypes were then modified in accordance with these 34 addenda to create a second suite of corresponding building simulations reflecting the same buildings compliant with Standard 90.1-2010. The building simulations were conducted using the DOE EnergyPlus building simulation software. The resulting energy use from the complete suite of 480 simulation runs was then converted to energy use intensity (EUI, or energy use per unit floor area) metrics (Site EUI, Primary EUI, and energy cost intensity [ECI]) results for each simulation. For each edition of the standard, these EUIs were then aggregated to a national basis for each prototype using weighting factors based

  13. [Application of systematic etiological analysis in final and differential diagnosis of hereditary hemolytic anemia].

    Science.gov (United States)

    Li, J Y; Gu, H H; Zheng, S J; Zha, Z S; Hua, M X; Jiang, J J; Cai, B; Zhou, L; Jia, Y; Fang, C P; Qian, B H

    2016-06-14

    Study on the application of the systematic analysis strategies of etiology in final and differential diagnosis of hereditary hemolytic anemia (HHA). Analysis of 1 506 patients with suspected hemolytic anemia (HA) in systematic hemolytic etiological analysis. ①1 413(94%) of the total 1 506 patients [male 799, female 707, median age 22-year-old (4 days to 86-year-old) ]were caused by membranopathy, hemoglobinopathy and enzymopathy, documented the three major causes of HHA. 369 cases (26%) of the 1 413 patients showed complex type of HA, which had the coexistence of two or more hereditary defects concerning HA in red cells, the other 1 044 cases (74%) were HA with single hemolytic cause. ②In 1 044 cases of single HA, hemoglobinopathy, membranopathy and enzymopathy was 22%, 63% and 15%, respectively. When single HA plused complex HA, the hemoglobinopathy, membranopathy and enzymopathy was 29%, 57% and 14% respectively. The difference was not statistically significant (P >0.05). ③ The most common double heterozygosis with different genetic defects was hemoglobinopathy complicated with membranopathy (50%, 184/369). The complex HA was also found in patients with the enzymopathy complicated with membranopathy (18%, 66/369) and with hemoglobinopathy (4%, 13/369). Some of complex HA patients had the same kinds of genetic defects which means double hemoglobinopathies (29 cases, 8% ), membranopathies (57 cases, 15% ) and enzymopathies (9 cases, 2%). Other kinds (11 cases, 3%) of complex HA, anemia and jaundice were seen in HAA patients accompanied with acquired and secondary defects or other system abnormalities. The parallel etiologic examination of three major genetic hemolytic diseases can be 94% of patients for classification. The results showed that the first cause of HAA was membranopathy, second hemoglobinopathy and then enzymopathy. Complex hemolysis is not uncommon and single factor analysis alone is not enough to provide scientific basis for diagnosis.

  14. An Analysis of Stative Verbs Used with the Progressive Aspect in Corpus-Informed Textbooks

    Science.gov (United States)

    Belli, Serap Atasever

    2018-01-01

    This study was designed to investigate whether contemporary corpus-informed grammar textbooks written for English language learners and teachers presented the progressive use of stative verbs and if yes, which stative verbs were presented to occur with the progressive aspect and for which functions they took this aspect. A corpus of six electronic…

  15. Health systems analysis of eye care services in Zambia: evaluating progress towards VISION 2020 goals.

    Science.gov (United States)

    Bozzani, Fiammetta Maria; Griffiths, Ulla Kou; Blanchet, Karl; Schmidt, Elena

    2014-02-28

    VISION 2020 is a global initiative launched in 1999 to eliminate avoidable blindness by 2020. The objective of this study was to undertake a situation analysis of the Zambian eye health system and assess VISION 2020 process indicators on human resources, equipment and infrastructure. All eye health care providers were surveyed to determine location, financing sources, human resources and equipment. Key informants were interviewed regarding levels of service provision, management and leadership in the sector. Policy papers were reviewed. A health system dynamics framework was used to analyse findings. During 2011, 74 facilities provided eye care in Zambia; 39% were public, 37% private for-profit and 24% owned by Non-Governmental Organizations. Private facilities were solely located in major cities. A total of 191 people worked in eye care; 18 of these were ophthalmologists and eight cataract surgeons, equivalent to 0.34 and 0.15 per 250,000 population, respectively. VISION 2020 targets for inpatient beds and surgical theatres were met in six out of nine provinces, but human resources and spectacles manufacturing workshops were below target in every province. Inequalities in service provision between urban and rural areas were substantial. Shortage and maldistribution of human resources, lack of routine monitoring and inadequate financing mechanisms are the root causes of underperformance in the Zambian eye health system, which hinder the ability to achieve the VISION 2020 goals. We recommend that all VISION 2020 process indicators are evaluated simultaneously as these are not individually useful for monitoring progress.

  16. Durability Modeling of Environmental Barrier Coating (EBC Using Finite Element Based Progressive Failure Analysis

    Directory of Open Access Journals (Sweden)

    Ali Abdul-Aziz

    2014-01-01

    Full Text Available The necessity for a protecting guard for the popular ceramic matrix composites (CMCs is getting a lot of attention from engine manufacturers and aerospace companies. The CMC has a weight advantage over standard metallic materials and more performance benefits. However, these materials undergo degradation that typically includes coating interface oxidation as opposed to moisture induced matrix which is generally seen at a higher temperature. Additionally, other factors such as residual stresses, coating process related flaws, and casting conditions may influence the degradation of their mechanical properties. These durability considerations are being addressed by introducing highly specialized form of environmental barrier coating (EBC that is being developed and explored in particular for high temperature applications greater than 1100°C. As a result, a novel computational simulation approach is presented to predict life for EBC/CMC specimen using the finite element method augmented with progressive failure analysis (PFA that included durability, damage tracking, and material degradation model. The life assessment is carried out using both micromechanics and macromechanics properties. The macromechanics properties yielded a more conservative life for the CMC specimen as compared to that obtained from the micromechanics with fiber and matrix properties as input.

  17. Recent progress in fission track analysis and its applications in China

    International Nuclear Information System (INIS)

    Wang, S.C.; Kang, T.S.; Jing, G.R.

    1993-01-01

    Fission track analysis (FTA) has been developed and applied in China since 1985. Since then great efforts have been made on methodology and applications. In order to improve the accuracy of fission track dating, zeta calibration constants have been determined against NBS SRM 962 standard uranium glass and seven age standards. TINT method and silver coating were used to increase the density and contrast of confined spontaneous fission tracks on apatite. Based on the fanning model of fission track annealing for apatite presented by Laslett, G.M., a forward computer modeling of track shortening and age evolution was completed and an inverse method of modeling thermal histories from apatite fission track data is underway. Apatite fission track data (age and track length), zircon age and forward modeling method have been used to reveal thermal and tectonic histories of several sedimentary basins and of a collision zone in China. In this presentation some progress in methodology and application will be presented and discussed. (Author)

  18. Recent progress on fingerprint visualization and analysis by imaging ridge residue components.

    Science.gov (United States)

    Su, Bin

    2016-04-01

    Fingerprints have long been and are still considered to be the gold standard for personal identification in forensic investigations. Developing or enhancing the visualization of invisible fingerprints, so-called latent fingerprints (LFPs), remains to be the core subject in forensic science. Moreover, the past few years have witnessed a renewal of research interest in the possibility that a fingerprint can provide additional information than just identification of individuals, such as personal traits, the presence of human metabolites with diagnostic values, and the evidence of contact with explosives or illicit drugs. Fingerprint analysis has manifested itself as a research area far beyond the scope of forensics, to which not only conventional fingerprint examiners but also researchers from chemistry, biochemistry, medical science, material science, and nanotechnology fields have made significant contributions in recent years. Beginning with a brief overview of the components present in LFP residue that essentially determines which method or reagent will give the best visualization result, this paper reviews the progress since 2007 on new reagents and methods developed for LFP visualization and simultaneous detection of specific chemicals present in the LFP residue, with an emphasis on the utilization of mass spectrometry, infrared spectroscopy, nanoparticles, and immunogenic and nucleic acid reagents.

  19. Relating plastic in the ocean to ecological harm, a review of recent progress in risk analysis

    Science.gov (United States)

    Schuyler, Q. A.; Hardesty, B. D.; Wilcox, C.; van Sebille, E.; Mallos, N. J.; Leonard, G. H.

    2016-02-01

    Plastic pollution in the ocean is emerging as a global environmental concern. Estimates suggest that we dump on the order of 8.4 million tons of plastic in the ocean each year. This plastic reaches substantial concentrations, with at sea sampling measuring densities over 580,000 items per square kilometer. However, it is difficult to relate this exposure to resulting ecological impacts. Animals dying due to plastic ingestion or entanglement may not was ahsore, and sampling at sea is expensive and infrequent. Thus demonstrating a direct relationship between plastic in the envioronment and harm to marine wildlife is challenging. Here we review current progress on risk assessment for impacts to marine wildlife from plastic pollution. The analyses we review range from expert elicitation to integrated statistical and physical models. They range widely in scope, from estimates at the individual level to who taxa analysis. Some of the analyses reach only to exposure to the pressure, whie others carry through to estimate demographic impacts and even mortality due to ingestion of or entanglement in plastic debris in the ocean. We summarize the results of these studies, and provide a roadmap for future contributions toward estimating the actual ecological impact of plastic pollution.

  20. Fuselage Versus Subcomponent Panel Response Correlation Based on ABAQUS Explicit Progressive Damage Analysis Tools

    Science.gov (United States)

    Gould, Kevin E.; Satyanarayana, Arunkumar; Bogert, Philip B.

    2016-01-01

    Analysis performed in this study substantiates the need for high fidelity vehicle level progressive damage analyses (PDA) structural models for use in the verification and validation of proposed sub-scale structural models and to support required full-scale vehicle level testing. PDA results are presented that capture and correlate the responses of sub-scale 3-stringer and 7-stringer panel models and an idealized 8-ft diameter fuselage model, which provides a vehicle level environment for the 7-stringer sub-scale panel model. Two unique skin-stringer attachment assumptions are considered and correlated in the models analyzed: the TIE constraint interface versus the cohesive element (COH3D8) interface. Evaluating different interfaces allows for assessing a range of predicted damage modes, including delamination and crack propagation responses. Damage models considered in this study are the ABAQUS built-in Hashin procedure and the COmplete STress Reduction (COSTR) damage procedure implemented through a VUMAT user subroutine using the ABAQUS/Explicit code.

  1. Interface Finite Elements for the Analysis of Fracture Initiation and Progression

    Science.gov (United States)

    Ambur, Damodar R. (Technical Monitor); Johnson, Eric R.

    2003-01-01

    Progressive failure analyses (PFA) are important for the prediction of residual strength and damage tolerance of vehicle structures, and to predict the energy absorbing capability of vehicle structures under crash-type loads. Typically continuum damage mechanics (CDM) and fracture mechanics (FM) are the methods used for PFA. The method of interfacial damage mechanics (IDM) is used for PFA in this research. IDM has capabilities intermediate between CDM and FM, and is used to numerically model the initiation, growth, and arrest of cracks. IDM smooths the stress singularity at the crack tip, and is easily adaptable with other nonlinearties such as plasticity and material damage. IDM is implemented by user-defined interface elements in the ABAQUS/ Standard structural analysis software package. The structural components selected to demonstrate the effectiveness PFA using interface elements are, for the most part, those with published test data. These structural components were subjected to quasi-static loading in the tests. Thus, the ABAQUS analyses are used to predict geometrically and materially nonlinear equilibrium states. Impact loading, dynamic fracture, reflected stress waves, inertia, and time dependent material behavior are not considered.

  2. Understanding students’ misconceptions: An analysis of final Grade 12 examination questions in geometry

    Directory of Open Access Journals (Sweden)

    Kakoma Luneta

    2015-06-01

    Full Text Available The role geometry plays in real life makes it a core component of mathematics that students must understand and master. Conceptual knowledge of geometric concepts goes beyond the development of skills required to manipulate geometric shapes. This study is focused on errors students made when solving coordinate geometry problems in the final Grade 12 examination in South Africa. An analysis of 1000 scripts from the 2008 Mathematics examination was conducted. This entailed a detailed analysis of one Grade 12 geometry examination question. Van Hiele levels of geometrical thought were used as a lens to understand students’ knowledge of geometry. Studies show that Van Hiele levels are a good descriptor of current and future performance in geometry. This study revealed that whilst students in Grade 12 are expected to operate at level 3 and level 4, the majority were operating at level 2 of Van Hiele’s hierarchy. The majority of students did not understand most of the basic concepts in Euclidian transformation. Most of the errors were conceptual and suggested that students did not understand the questions and did not know what to do as a result. It is also noted that when students lack conceptual knowledge the consequences are so severe that they hardly respond to the questions in the examination.

  3. Transuranic-contaminated solid waste Treatment Development Facility. Final safety analysis report

    International Nuclear Information System (INIS)

    Warner, C.L.

    1979-07-01

    The Final Safety Analysis Report (FSAR) for the Transuranic-Contaminated Solid-Waste Treatment Facility has been prepared in compliance with the Department of Energy (DOE) Manual Chapter 0531, Safety of Nonreactor Nuclear Facilities. The Treatment Development Facility (TDF) at the Los Alamos Scientific Laboratory is a research and development facility dedicated to the study of radioactive-waste-management processes. This analysis addresses site assessment, facility design and construction, and the design and operating characteristics of the first study process, controlled air incineration and aqueous scrub off-gas treatment with respect to both normal and accident conditions. The credible accidents having potentially serious consequences relative to the operation of the facility and the first process have been analyzed and the consequences of each postulated credible accident are presented. Descriptions of the control systems, engineered safeguards, and administrative and operational features designed to prevent or mitigate the consequences of such accidents are presented. The essential features of the operating and emergency procedures, environmental protection and monitoring programs, as well as the health and safety, quality assurance, and employee training programs are described

  4. Reactor analysis support package (RASP). Volume 7. PWR set-point methodology. Final report

    International Nuclear Information System (INIS)

    Temple, S.M.; Robbins, T.R.

    1986-09-01

    This report provides an overview of the basis and methodology requirements for determining Pressurized Water Reactor (PWR) technical specifications related setpoints and focuses on development of the methodology for a reload core. Additionally, the report documents the implementation and typical methods of analysis used by PWR vendors during the 1970's to develop Protection System Trip Limits (or Limiting Safety System Settings) and Limiting Conditions for Operation. The descriptions of the typical setpoint methodologies are provided for Nuclear Steam Supply Systems as designed and supplied by Babcock and Wilcox, Combustion Engineering, and Westinghouse. The description of the methods of analysis includes the discussion of the computer codes used in the setpoint methodology. Next, the report addresses the treatment of calculational and measurement uncertainties based on the extent to which such information was available for each of the three types of PWR. Finally, the major features of the setpoint methodologies are compared, and the principal effects of each particular methodology on plant operation are summarized for each of the three types of PWR

  5. The Third International Intercomparison on EPR Tooth Dosimetry: Part 2, final analysis

    International Nuclear Information System (INIS)

    Wieser, A.; Debuyst, R.; Fattibene, P.; Meghzifene, A.; Onori, S.; Bayankin, S. N.; Brik, A.; Bugay, A.; Chumak, V.; Ciesielski, B.; Hoshi, M.; Imata, H.; Ivannikov, A.; Ivanov, D.; Junczewska, M.; Miyazawa, C.; Penkowski, M.; Pivovarov, S.; Romanyukha, A.; Romanyukha, L.; Schauer, D.; Scherbina, O.; Schultka, K.; Sholom, S.; Skvortsov, V.; Stepanenko, V.; Thomas, J. A.; Tielewuhan, E.; Toyoda, S.; Trompier, F.

    2006-01-01

    The objective of the Third International Intercomparison on EPR Tooth Dosimetry was to evaluate laboratories performing tooth enamel dosimetry <300 mGy. Final analysis of results included a correlation analysis between features of laboratory dose reconstruction protocols and dosimetry performance. Applicability of electron paramagnetic resonance (EPR) tooth dosimetry at low dose was shown at two applied dose levels of 79 and 176 mGy. Most (9 of 12) laboratories reported the dose to be within 50 mGy of the delivered dose of 79 mGy, and 10 of 12 laboratories reported the dose to be within 100 mGy of the delivered dose of 176 mGy. At the high-dose tested (704 mGy) agreement within 25% of the delivered dose was found in 10 laboratories. Features of EPR dose reconstruction protocols that affect dosimetry performance were found to be magnetic field modulation amplitude in EPR spectrum recording, EPR signal model in spectrum deconvolution and duration of latency period for tooth enamel samples after preparation. (authors)

  6. Transuranic-contaminated solid waste Treatment Development Facility. Final safety analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Warner, C.L. (comp.)

    1979-07-01

    The Final Safety Analysis Report (FSAR) for the Transuranic-Contaminated Solid-Waste Treatment Facility has been prepared in compliance with the Department of Energy (DOE) Manual Chapter 0531, Safety of Nonreactor Nuclear Facilities. The Treatment Development Facility (TDF) at the Los Alamos Scientific Laboratory is a research and development facility dedicated to the study of radioactive-waste-management processes. This analysis addresses site assessment, facility design and construction, and the design and operating characteristics of the first study process, controlled air incineration and aqueous scrub off-gas treatment with respect to both normal and accident conditions. The credible accidents having potentially serious consequences relative to the operation of the facility and the first process have been analyzed and the consequences of each postulated credible accident are presented. Descriptions of the control systems, engineered safeguards, and administrative and operational features designed to prevent or mitigate the consequences of such accidents are presented. The essential features of the operating and emergency procedures, environmental protection and monitoring programs, as well as the health and safety, quality assurance, and employee training programs are described.

  7. The analysis of factors associated with progression of isolated terminal ileal lesions.

    Directory of Open Access Journals (Sweden)

    Zhang Fangbin

    Full Text Available To assess the factors associated with the progression of isolated terminal ileal lesions (ITILs at colonoscopy in Chinese patients.Patients diagnosed with ITILs were enrolled. The ileoscopy was performed by two experienced gastroenterologists every 52 weeks. A logistic regression analysis was used to elucidate the factors associated with Crohn's disease (CD and mucosal healing. A log rank test was used to assess the differences of the cumulative proportion of CD and mucosal healing in different groups at different times.(1 A total of 34 patients were included and no patient had taken nonsteroidal anti-inflammatory drug in the last 6 months; eight (23.5% patients had a clinical diagnosis of CD, 14 (41.2% patients achieved mucosal healing, and 12 (35.3% patients showed no significant changes in the lesions at last follow-up. (2 The logistic regression analysis showed that only abdominal pain was a factor in the ITIL disease outcomes. (3 The cumulative proportion of CD in the abdominal pain group after 3 years was statistically higher than that in the non-abdominal pain group (42.7% vs. 6.2%, χ2 = 10.129, P = 0.001. However, the cumulative proportion of mucosal healing in the non-abdominal pain group was statistically higher than that in the abdominal pain group (73.3% vs. 5.6%, χ2 = 5.225, P = 0.022. (4 The numbers of lesions observed on the initial colonoscopy exams and the initial histologic findings were not related to the ITIL disease outcomes.Clinical symptoms may be related to ITIL disease outcomes. Patients with abdominal pain had a high likelihood of CD, whereas those without abdominal pain had a high likelihood of mucosal healing.

  8. The analysis of factors associated with progression of isolated terminal ileal lesions.

    Science.gov (United States)

    Fangbin, Zhang; Weiwei, Hao; Wugan, Zhao; Cong, Zheng; Yanjun, Chu; Feng, Xu

    2014-01-01

    To assess the factors associated with the progression of isolated terminal ileal lesions (ITILs) at colonoscopy in Chinese patients. Patients diagnosed with ITILs were enrolled. The ileoscopy was performed by two experienced gastroenterologists every 52 weeks. A logistic regression analysis was used to elucidate the factors associated with Crohn's disease (CD) and mucosal healing. A log rank test was used to assess the differences of the cumulative proportion of CD and mucosal healing in different groups at different times. (1) A total of 34 patients were included and no patient had taken nonsteroidal anti-inflammatory drug in the last 6 months; eight (23.5%) patients had a clinical diagnosis of CD, 14 (41.2%) patients achieved mucosal healing, and 12 (35.3%) patients showed no significant changes in the lesions at last follow-up. (2) The logistic regression analysis showed that only abdominal pain was a factor in the ITIL disease outcomes. (3) The cumulative proportion of CD in the abdominal pain group after 3 years was statistically higher than that in the non-abdominal pain group (42.7% vs. 6.2%, χ2 = 10.129, P = 0.001). However, the cumulative proportion of mucosal healing in the non-abdominal pain group was statistically higher than that in the abdominal pain group (73.3% vs. 5.6%, χ2 = 5.225, P = 0.022). (4) The numbers of lesions observed on the initial colonoscopy exams and the initial histologic findings were not related to the ITIL disease outcomes. Clinical symptoms may be related to ITIL disease outcomes. Patients with abdominal pain had a high likelihood of CD, whereas those without abdominal pain had a high likelihood of mucosal healing.

  9. Plutonium Finishing Plant (PFP) Final Safety Analysis Report (FSAR) [SEC 1 THRU 11

    International Nuclear Information System (INIS)

    ULLAH, M.K.

    2001-01-01

    The Plutonium Finishing Plant (PFP) is located on the US Department of Energy (DOE) Hanford Site in south central Washington State. The DOE Richland Operations (DOE-RL) Project Hanford Management Contract (PHMC) is with Fluor Hanford Inc. (FH). Westinghouse Safety Management Systems (WSMS) provides management support to the PFP facility. Since 1991, the mission of the PFP has changed from plutonium material processing to preparation for decontamination and decommissioning (D and D). The PFP is in transition between its previous mission and the proposed D and D mission. The objective of the transition is to place the facility into a stable state for long-term storage of plutonium materials before final disposition of the facility. Accordingly, this update of the Final Safety Analysis Report (FSAR) reflects the current status of the buildings, equipment, and operations during this transition. The primary product of the PFP was plutonium metal in the form of 2.2-kg, cylindrical ingots called buttoms. Plutonium nitrate was one of several chemical compounds containing plutonium that were produced as an intermediate processing product. Plutonium recovery was performed at the Plutonium Reclamation Facility (PRF) and plutonium conversion (from a nitrate form to a metal form) was performed at the Remote Mechanical C (RMC) Line as the primary processes. Plutonium oxide was also produced at the Remote Mechanical A (RMA) Line. Plutonium processed at the PFP contained both weapons-grade and fuels-grade plutonium materials. The capability existed to process both weapons-grade and fuels-grade material through the PRF and only weapons-grade material through the RMC Line although fuels-grade material was processed through the line before 1984. Amounts of these materials exist in storage throughout the facility in various residual forms left from previous years of operations

  10. Plutonium Finishing Plant (PFP) Final Safety Analysis Report (FSAR) [SEC 1 THRU 11

    Energy Technology Data Exchange (ETDEWEB)

    ULLAH, M K

    2001-02-26

    The Plutonium Finishing Plant (PFP) is located on the US Department of Energy (DOE) Hanford Site in south central Washington State. The DOE Richland Operations (DOE-RL) Project Hanford Management Contract (PHMC) is with Fluor Hanford Inc. (FH). Westinghouse Safety Management Systems (WSMS) provides management support to the PFP facility. Since 1991, the mission of the PFP has changed from plutonium material processing to preparation for decontamination and decommissioning (D and D). The PFP is in transition between its previous mission and the proposed D and D mission. The objective of the transition is to place the facility into a stable state for long-term storage of plutonium materials before final disposition of the facility. Accordingly, this update of the Final Safety Analysis Report (FSAR) reflects the current status of the buildings, equipment, and operations during this transition. The primary product of the PFP was plutonium metal in the form of 2.2-kg, cylindrical ingots called buttoms. Plutonium nitrate was one of several chemical compounds containing plutonium that were produced as an intermediate processing product. Plutonium recovery was performed at the Plutonium Reclamation Facility (PRF) and plutonium conversion (from a nitrate form to a metal form) was performed at the Remote Mechanical C (RMC) Line as the primary processes. Plutonium oxide was also produced at the Remote Mechanical A (RMA) Line. Plutonium processed at the PFP contained both weapons-grade and fuels-grade plutonium materials. The capability existed to process both weapons-grade and fuels-grade material through the PRF and only weapons-grade material through the RMC Line although fuels-grade material was processed through the line before 1984. Amounts of these materials exist in storage throughout the facility in various residual forms left from previous years of operations.

  11. Final report on key comparison CCQM-K100: Analysis of copper in ethanol

    Science.gov (United States)

    Zhou, Tao; Kakoulides, Elias; Zhu, Yanbei; Jaehrling, Reinhard; Rienitz, Olaf; Saxby, David; Phukphatthanachai, Pranee; Yafa, Charun; Labarraque, Guillaume; Cankur, Oktay; Can, Süleyman Z.; Konopelko, Leonid A.; Kustikov, Yu A.; Caciano de Sena, Rodrigo; Marques Rodrigues, Janaina; Fonseca Sarmanho, Gabriel; Fortunato de Carvalho Rocha, Werickson; dos Reis, Lindomar Augusto

    2014-01-01

    The increase in renewable sources in the energy matrix of the countries is an effort to reduce dependency on crude oil and the environmental impacts associated with its use. In order to help overcome the lack of widely accepted quality standards for fuel ethanol and to guarantee its competitiveness in the international trade market, the NMIs have been working to develop certified reference materials for bio-fuels and measurement methods. Inorganic impurities such as Cu, Na and Fe may be present in the fuel ethanol and their presence is associated with corrosion and the formation of oxide deposits in some engine parts. The key comparison CCQM-K100 was carried out under the auspices of the Inorganic Analysis Working Group (IAWG) and the coordination of the National Institute of Metrology, Quality and Technology (INMETRO). The objective of this key comparison was to compare the measurement capabilities of the participants for the determination of Cu in fuel ethanol. Ten NMIs participated in this exercise and most of them used the isotopic dilution method for determining the amount of Cu. The median was chosen as key comparison reference value (KCRV). The assigned KCRV for the Cu content was 0.3589 µg/g with a combined standard uncertainty of 0.0014 µg/g. In general, there is a good agreement among the participants' results. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  12. No evidence of real progress in treatment of acute pain, 1993–2012: scientometric analysis

    Directory of Open Access Journals (Sweden)

    Correll DJ

    2014-04-01

    Full Text Available Darin J Correll, Kamen V Vlassakov, Igor Kissin Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Abstract: Over the past 2 decades, many new techniques and drugs for the treatment of acute pain have achieved widespread use. The main aim of this study was to assess the progress in their implementation using scientometric analysis. The following scientometric indices were used: 1 popularity index, representing the share of articles on a specific technique (or a drug relative to all articles in the field of acute pain; 2 index of change, representing the degree of growth in publications on a topic compared to the previous period; and 3 index of expectations, representing the ratio of the number of articles on a topic in the top 20 journals relative to the number of articles in all (>5,000 biomedical journals covered by PubMed. Publications on specific topics (ten techniques and 21 drugs were assessed during four time periods (1993–1997, 1998–2002, 2003–2007, and 2008–2012. In addition, to determine whether the status of routine acute pain management has improved over the past 20 years, we analyzed surveys designed to be representative of the national population that reflected direct responses of patients reporting pain scores. By the 2008–2012 period, popularity index had reached a substantial level (≥5% only with techniques or drugs that were introduced 30–50 years ago or more (epidural analgesia, patient-controlled analgesia, nerve blocks, epidural analgesia for labor or delivery, bupivacaine, and acetaminophen. In 2008–2012, promising (although modest changes of index of change and index of expectations were found only with dexamethasone. Six national surveys conducted for the past 20 years demonstrated an unacceptably high percentage of patients experiencing moderate or severe pain with not even a trend toward outcome improvement. Thus

  13. Identification of Major Signaling Pathways in Prion Disease Progression Using Network Analysis.

    Directory of Open Access Journals (Sweden)

    Khalique Newaz

    Full Text Available Prion diseases are transmissible neurodegenerative diseases that arise due to conformational change of normal, cellular prion protein (PrPC to protease-resistant isofrom (rPrPSc. Deposition of misfolded PrpSc proteins leads to an alteration of many signaling pathways that includes immunological and apoptotic pathways. As a result, this culminates in the dysfunction and death of neuronal cells. Earlier works on transcriptomic studies have revealed some affected pathways, but it is not clear which is (are the prime network pathway(s that change during the disease progression and how these pathways are involved in crosstalks with each other from the time of incubation to clinical death. We perform network analysis on large-scale transcriptomic data of differentially expressed genes obtained from whole brain in six different mouse strain-prion strain combination models to determine the pathways involved in prion diseases, and to understand the role of crosstalks in disease propagation. We employ a notion of differential network centrality measures on protein interaction networks to identify the potential biological pathways involved. We also propose a crosstalk ranking method based on dynamic protein interaction networks to identify the core network elements involved in crosstalk with different pathways. We identify 148 DEGs (differentially expressed genes potentially related to the prion disease progression. Functional association of the identified genes implicates a strong involvement of immunological pathways. We extract a bow-tie structure that is potentially dysregulated in prion disease. We also propose an ODE model for the bow-tie network. Predictions related to diseased condition suggests the downregulation of the core signaling elements (PI3Ks and AKTs of the bow-tie network. In this work, we show using transcriptomic data that the neuronal dysfunction in prion disease is strongly related to the immunological pathways. We conclude that

  14. DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression.

    Science.gov (United States)

    Torres-Rendon, A; Stewart, R; Craig, G T; Wells, M; Speight, P M

    2009-06-01

    Abnormal DNA content (aneuploidy) has been associated with malignant and premalignant epithelial lesions. The presence of aneuploidy in tumours at an early stage and in dysplastic lesions suggests that analysis of DNA content may be a useful marker for determination of prognosis in these lesions. The aim of this study was to use DNA image cytometry to evaluate aneuploidy in oral dysplastic lesions and to determine whether aneuploidy is associated with malignant progression. Forty-two lesions of oral epithelial dysplasias (OED) that had progressed to oral squamous cell carcinoma (OSCC) and 44 lesions that did not progress were analysed for DNA ploidy using image cytometry of nuclear monolayers prepared from paraffin-embedded tissue. Forty-two OSCC that had arisen from the OED cases and five samples of normal oral mucosa samples (NOM) were also examined. Aneuploidy was found in 14/42 (33.3%) of the OED that progressed, but in only 5/44 (11.3%) of OED that did not progress (p=0.01). A total of 19 OED were aneuploid of which 74% showed malignant progression compared to only 42% of the diploid lesions. The sensitivity and specificity of DNA image cytometry to detect cases with high risk of malignant progression was 0.33 and 0.88, respectively. The PPV and NPV were 0.74 and 0.58. We conclude that aneuploid oral dysplastic lesions have a high risk of malignant progression and that DNA image cytometry might help to identify those lesions most at risk.

  15. Sex Differences in Mathematics and Science Achievement: A Meta-Analysis of National Assessment of Educational Progress Assessments

    Science.gov (United States)

    Reilly, David; Neumann, David L.; Andrews, Glenda

    2015-01-01

    Gender gaps in the development of mathematical and scientific literacy have important implications for the general public's understanding of scientific issues and for the underrepresentation of women in science, technology, engineering, and math. We subjected data from the National Assessment of Educational Progress to a meta-analysis to examine…

  16. The fuzzy set theory application to the analysis of accident progression event trees with phenomenological uncertainty issues

    International Nuclear Information System (INIS)

    Chun, Moon-Hyun; Ahn, Kwang-Il

    1991-01-01

    Fuzzy set theory provides a formal framework for dealing with the imprecision and vagueness inherent in the expert judgement, and therefore it can be used for more effective analysis of accident progression of PRA where experts opinion is a major means for quantifying some event probabilities and uncertainties. In this paper, an example application of the fuzzy set theory is first made to a simple portion of a given accident progression event tree with typical qualitative fuzzy input data, and thereby computational algorithms suitable for application of the fuzzy set theory to the accident progression event tree analysis are identified and illustrated with example applications. Then the procedure used in the simple example is extended to extremely complex accident progression event trees with a number of phenomenological uncertainty issues, i.e., a typical plant damage state 'SEC' of the Zion Nuclear Power Plant risk assessment. The results show that the fuzzy averages of the fuzzy outcomes are very close to the mean values obtained by current methods. The main purpose of this paper is to provide a formal procedure for application of the fuzzy set theory to accident progression event trees with imprecise and qualitative branch probabilities and/or with a number of phenomenological uncertainty issues. (author)

  17. NUMERICAL ANALYSIS AND EXPERIMENTAL INVESTIGATION OF DISK SPRING CONFIGURATIONS WITH REGARD TO LOAD CAPACITY OF SAFETY PROGRESSIVE GEARS

    Directory of Open Access Journals (Sweden)

    Paweł LONKWIC

    2016-09-01

    Full Text Available The paper investigates the effect of various disk spring package configurations on brake load of safety progressive gears. The numerical analysis is performed using the Abaqus/CAE software and the designed 3D models. The numerical results are then verified in experimental tests. The tests also examine the effect of lubrication on brake load of spring packages. In addition, the paper investigates the work conditions of safety progressive gears at emergency braking. The experimental results show agreement with the numerical results.

  18. Nivolumab for Patients With Advanced Melanoma Treated Beyond Progression: Analysis of 2 Phase 3 Clinical Trials

    DEFF Research Database (Denmark)

    Long, Georgina V; Weber, Jeffrey S; Larkin, James

    2017-01-01

    IMPORTANCE: Immune checkpoint inhibitors have demonstrated atypical response patterns, which may not be fully captured by conventional response criteria. There is a need to better understand the potential benefit of continued immune checkpoint inhibition beyond progression. OBJECTIVE: To evaluate...

  19. Word-finding difficulty: a clinical analysis of the progressive aphasias

    Science.gov (United States)

    Rohrer, Jonathan D.; Knight, William D.; Warren, Jane E.; Fox, Nick C.; Rossor, Martin N.; Warren, Jason D.

    2008-01-01

    The patient with word-finding difficulty presents a common and challenging clinical problem. The complaint of ‘word-finding difficulty’ covers a wide range of clinical phenomena and may signify any of a number of distinct pathophysiological processes. Although it occurs in a variety of clinical contexts, word-finding difficulty generally presents a diagnostic conundrum when it occurs as a leading or apparently isolated symptom, most often as the harbinger of degenerative disease: the progressive aphasias. Recent advances in the neurobiology of the focal, language-based dementias have transformed our understanding of these processes and the ways in which they breakdown in different diseases, but translation of this knowledge to the bedside is far from straightforward. Speech and language disturbances in the dementias present unique diagnostic and conceptual problems that are not fully captured by classical models derived from the study of vascular and other acute focal brain lesions. This has led to a reformulation of our understanding of how language is organized in the brain. In this review we seek to provide the clinical neurologist with a practical and theoretical bridge between the patient presenting with word-finding difficulty in the clinic and the evidence of the brain sciences. We delineate key illustrative speech and language syndromes in the degenerative dementias, compare these syndromes with the syndromes of acute brain damage, and indicate how the clinical syndromes relate to emerging neurolinguistic, neuroanatomical and neurobiological insights. We propose a conceptual framework for the analysis of word-finding difficulty, in order both better to define the patient's complaint and its differential diagnosis for the clinician and to identify unresolved issues as a stimulus to future work. PMID:17947337

  20. Final safety analysis report for the Galileo Mission: Volume 2: Book 1, Accident model document

    Energy Technology Data Exchange (ETDEWEB)

    1988-12-15

    The Accident Model Document (AMD) is the second volume of the three volume Final Safety Analysis Report (FSAR) for the Galileo outer planetary space science mission. This mission employs Radioisotope Thermoelectric Generators (RTGs) as the prime electrical power sources for the spacecraft. Galileo will be launched into Earth orbit using the Space Shuttle and will use the Inertial Upper Stage (IUS) booster to place the spacecraft into an Earth escape trajectory. The RTG's employ silicon-germanium thermoelectric couples to produce electricity from the heat energy that results from the decay of the radioisotope fuel, Plutonium-238, used in the RTG heat source. The heat source configuration used in the RTG's is termed General Purpose Heat Source (GPHS), and the RTG's are designated GPHS-RTGs. The use of radioactive material in these missions necessitates evaluations of the radiological risks that may be encountered by launch complex personnel as well as by the Earth's general population resulting from postulated malfunctions or failures occurring in the mission operations. The FSAR presents the results of a rigorous safety assessment, including substantial analyses and testing, of the launch and deployment of the RTGs for the Galileo mission. This AMD is a summary of the potential accident and failure sequences which might result in fuel release, the analysis and testing methods employed, and the predicted source terms. Each source term consists of a quantity of fuel released, the location of release and the physical characteristics of the fuel released. Each source term has an associated probability of occurrence. 27 figs., 11 tabs.

  1. Modeling and Predicting AD Progression by Regression Analysis of Sequential Clinical Data

    KAUST Repository

    Xie, Qing

    2016-02-23

    Alzheimer\\'s Disease (AD) is currently attracting much attention in elders\\' care. As the increasing availability of massive clinical diagnosis data, especially the medical images of brain scan, it is highly significant to precisely identify and predict the potential AD\\'s progression based on the knowledge in the diagnosis data. In this paper, we follow a novel sequential learning framework to model the disease progression for AD patients\\' care. Different from the conventional approaches using only initial or static diagnosis data to model the disease progression for different durations, we design a score-involved approach and make use of the sequential diagnosis information in different disease stages to jointly simulate the disease progression. The actual clinical scores are utilized in progress to make the prediction more pertinent and reliable. We examined our approach by extensive experiments on the clinical data provided by the Alzheimer\\'s Disease Neuroimaging Initiative (ADNI). The results indicate that the proposed approach is more effective to simulate and predict the disease progression compared with the existing methods.

  2. Development of a beam probe diagnostic system for the United Aircraft ''LITE'' program. Final progress report, 1 April 1974--31 March 1975

    International Nuclear Information System (INIS)

    Stufflebeam, J.H.; Jennings, W.C.; Connor, K.A.; Hickok, R.L.

    1975-07-01

    A heavy ion beam probe diagnostic system for the LITE plasma device was designed, fabricated, tested and installed. The beam was aligned and slaved to the LITE magnetic field and the predicted defocusing of the beam was confirmed. A sophisticated Beam Trajectory Programmer to control the operation of the beam probe system was developed and placed into operation. The electrostatic energy analyzer detector system was installed and preliminary noise measurements were made. The system is now ready for final testing under full plasma operating conditions. (U.S.)

  3. Recovery of valuable chlorosilane intermediates by a novel waste conversion process. Technical report for phase IIIA (final) and phase IIIB (progress)

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, K.E.

    1998-10-01

    From July 1994 through May 1998, direct process residue (DPR) hydrogenolysis has been studied in the laboratory, at a small Pilot Plant, and finally at a larger Pilot Plant within Dow Corning`s Carrollton, Kentucky plant. The system reacts filtered DPR with monomer at high temperature and pressure. The process demonstrates DPR conversion up to 86%. The reaction product contains high concentrations of valuable monomers such as dimethyldichlorosilane and methyldichlorosilane. A larger DPR hydrogenolysis reactor based on these results is being designed for operation in Europe at Dow Corning`s Barry, Wales site.

  4. Retrospective analysis of anthropometric and fitness characteristics associated with long-term career progression in Rugby League.

    Science.gov (United States)

    Till, Kevin; Cobley, Steve; O'Hara, John; Morley, David; Chapman, Chris; Cooke, Carlton

    2015-05-01

    The current study retrospectively investigated the differences in anthropometric and fitness characteristics of junior rugby league players selected onto a talent identification and development (TID) programme between long-term career progression levels (i.e., amateur, academy, professional). Retrospective design. Former junior rugby league players (N=580) selected to a TID programme were grouped according to their career progression level. Anthropometric (height, sitting height, body mass and sum of four skinfolds), maturational and fitness (power, speed, change of direction speed and estimated V̇O2max) assessments were conducted at 13-15 years. Multivariate analysis of covariance (MANCOVA) analyzed differences between career progression levels controlling for chronological age. 57.1% and 12.1% of players selected to the TID programme progressed to academy and professional levels in rugby league, respectively. Sum of four skinfolds (η(2)=0.03), vertical jump (η(2)=0.02), 10 m (η(2)=0.02), 20 m (η(2)=0.02), 30 m (η(2)=0.02), and 60 m (η(2)=0.03) speed, agility 505 left (η(2)=0.06), agility 505 right (η(2)=0.05) and estimated V̇O2max (η(2)=0.03) were superior within junior players who progressed to professional compared to amateur levels. No significant differences were identified between future academy and professional players for any measure. Findings suggest that lower sum of four skinfolds and advanced fitness characteristics within junior (13-15 years) rugby league players may partially contribute to long-term career progression. Therefore, TID programmes within rugby league should aim to assess and develop body composition and fitness characteristics, especially change of direction speed. However, TID programmes should also consider technical, tactical and psycho-social characteristics of junior rugby league players that may be important for long-term career progression. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All

  5. Scientific progress regarding neural regeneration in the Web of Science: A 10-year bibliometric analysis.

    Science.gov (United States)

    Pan, Yuntao; Zhang, Yuhua; Gao, Xiaopei; Jia, Jia; Gao, Jiping; Ma, Zheng

    2013-12-25

    Science and Technology programs were the majority. Our bibliometric analysis provides a historical perspective on the progress of neural regeneration research. At present, the number of articles addressing neural regeneration is increasing rapidly; however, through analysis of citations it is clear that there is a long way to go to improve the academic quality.

  6. Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis.

    Directory of Open Access Journals (Sweden)

    Rachael Natrajan

    2016-02-01

    Full Text Available The intra-tumor diversity of cancer cells is under intense investigation; however, little is known about the heterogeneity of the tumor microenvironment that is key to cancer progression and evolution. We aimed to assess the degree of microenvironmental heterogeneity in breast cancer and correlate this with genomic and clinical parameters.We developed a quantitative measure of microenvironmental heterogeneity along three spatial dimensions (3-D in solid tumors, termed the tumor ecosystem diversity index (EDI, using fully automated histology image analysis coupled with statistical measures commonly used in ecology. This measure was compared with disease-specific survival, key mutations, genome-wide copy number, and expression profiling data in a retrospective study of 510 breast cancer patients as a test set and 516 breast cancer patients as an independent validation set. In high-grade (grade 3 breast cancers, we uncovered a striking link between high microenvironmental heterogeneity measured by EDI and a poor prognosis that cannot be explained by tumor size, genomics, or any other data types. However, this association was not observed in low-grade (grade 1 and 2 breast cancers. The prognostic value of EDI was superior to known prognostic factors and was enhanced with the addition of TP53 mutation status (multivariate analysis test set, p = 9 × 10-4, hazard ratio = 1.47, 95% CI 1.17-1.84; validation set, p = 0.0011, hazard ratio = 1.78, 95% CI 1.26-2.52. Integration with genome-wide profiling data identified losses of specific genes on 4p14 and 5q13 that were enriched in grade 3 tumors with high microenvironmental diversity that also substratified patients into poor prognostic groups. Limitations of this study include the number of cell types included in the model, that EDI has prognostic value only in grade 3 tumors, and that our spatial heterogeneity measure was dependent on spatial scale and tumor size.To our knowledge, this is the first

  7. Fukushima Daiichi Unit 1 Accident Progression Uncertainty Analysis and Implications for Decommissioning of Fukushima Reactors - Volume I.

    Energy Technology Data Exchange (ETDEWEB)

    Gauntt, Randall O. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Mattie, Patrick D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-01-01

    Sandia National Laboratories (SNL) has conducted an uncertainty analysis (UA) on the Fukushima Daiichi unit (1F1) accident progression with the MELCOR code. The model used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). That study focused on reconstructing the accident progressions, as postulated by the limited plant data. This work was focused evaluation of uncertainty in core damage progression behavior and its effect on key figures-of-merit (e.g., hydrogen production, reactor damage state, fraction of intact fuel, vessel lower head failure). The primary intent of this study was to characterize the range of predicted damage states in the 1F1 reactor considering state of knowledge uncertainties associated with MELCOR modeling of core damage progression and to generate information that may be useful in informing the decommissioning activities that will be employed to defuel the damaged reactors at the Fukushima Daiichi Nuclear Power Plant. Additionally, core damage progression variability inherent in MELCOR modeling numerics is investigated.

  8. Analysis of progression of cervical OPLL using computerized tomography: typical sign of maturation of OPLL mass.

    Science.gov (United States)

    Choi, Byung-Wan; Baek, Dong-Hoon; Sheffler, Lindsey C; Chang, Han

    2015-07-17

    OBJECT The progression of cervical ossification of the posterior longitudinal ligament (OPLL) can lead to increase in the size of the OPLL mass and aggravation of neurological symptoms. In the present study, the authors aimed to analyze the progression of cervical OPLL by using CT imaging, elucidate the morphology of OPLL masses, and evaluate the factors associated with the progression of cervical OPLL. METHODS Sixty patients with cervical OPLL were included. All underwent an initial CT examination and had at least 24 months' follow-up with CT. The mean duration of follow-up was 29.6 months. Fourteen patients (Group A) had CT evidence of OPLL progression, and 46 (Group B) did not show evidence of progression on CT. The 2 groups were compared with respect to the following variables: sex, age, number of involved segments, type of OPLL, and treatment methods. The CT findings, such as the connection of an OPLL mass with the vertebral body and formation of trabeculation in the mass, were evaluated. RESULTS Sex and treatment modality were not associated with OPLL progression. The mean age of the patients in Group A was significantly lower than that in Group B (p = 0.03). The mean number of involved segments was 5.3 in Group A and 3.6 in Group B (p = 0.002). Group A had a higher proportion of cases with the mixed type of OPLL, whereas Group B had a higher proportion of cases with the segmental type (p = 0.02). A connection between the vertebral body and OPLL mass and trabeculation formation were more common in Group B (p cervical OPLL is associated with younger age, involvement of multiple levels, and mixed-type morphology. OPLL masses that are contiguous with the vertebral body and have trabecular formation are useful findings for identifying masses that are less likely to progress.

  9. Mutational analysis of root characters in food plants. Proceedings of a final research coordination meeting

    International Nuclear Information System (INIS)

    2006-04-01

    genomics and proteomics to address important agricultural issues, supporting successful agricultural production with minimal impact on the environment. Improvements in screening techniques and development of molecular markers are ways to alleviate the need for direct root assessment and speed up selection in plant breeding programmes. Root architecture models provide a tool to address the space-time dynamics of the soil/plant system. Genetic analysis of quantitative traits and methods in forward and reverse genetics will also contribute to breeding crops with root systems suitable for a range of agricultural environments. Recent evidence indicates that plant stresses are mediated by changes at the root system level. In this context, mutants and mutational analysis of root characters are becoming significant elements in research that seeks to clarify the ways by which root structure and function respond to environmental cues and alleviate the impact of stress. This publication summarizes the results presented at the third and final Research Coordination meeting (RCM) of the CRP, which was held in Antalya, Turkey, 11-15 October 2004

  10. Engineering Evaluation/Cost Analysis for Power Burst Facility (PER-620) Final End State and PBF Vessel Disposal

    Energy Technology Data Exchange (ETDEWEB)

    B. C. Culp

    2007-05-01

    Preparation of this engineering evaluation/cost analysis is consistent with the joint U.S. Department of Energy and U.S. Environmental Protection Agency Policy on Decommissioning of Department of Energy Facilities Under the Comprehensive Environmental Response, Compensation, and Liability Act, (DOE and EPA 1995) which establishes the Comprehensive Environmental, Response, Compensation, and Liability Act non-time critical removal action process as an approach for decommissioning. The scope of this engineering evaluation/cost analysis is to evaluate alternatives and recommend a preferred alternative for the final end state of the PBF and the final disposal location for the PBF vessel.

  11. Conjoint utility analysis of technical maturity and project progress of construction project

    Directory of Open Access Journals (Sweden)

    Ma Wei

    2016-01-01

    Full Text Available In this paper, taking construction project as the research object, the relationship between the project maturity index calculated by the construction project technical risks with different fine degree and the project progress index is studied, and the equilibrium relationship between the Party A’s utility curve and the Party B’s cost curve of using project maturity index and project progress index as the research variables is analyzed. The results show that, when the construction project technical risk division is more precise, the conjoint utility of the project's technical maturity index and the project progress is higher, and the project’s Party A and Party B two sides are closer to the optimal equilibrium. This shows that the construction project technical risk must be finely divided, and managed and controlled respectively, which will help to improve the conjoint utility of the project Party A and Party B two sides.

  12. Analysis of the foetal heart rate in cardiotocographic recordings through a progressive characterization of decelerations

    Directory of Open Access Journals (Sweden)

    Fuentealba Patricio

    2017-09-01

    Full Text Available The main purpose of this work is to propose a new method for characterization and visualization of FHR deceleration episodes in terms of their depth, length and location. This is performed through the estimation of a progressive baseline computed using a median filter allowing to identify and track the evolution of decelerations in cardiotocographic CTG recordings. The proposed method has been analysed using three representative cases of normal and pathological CTG recordings extracted from the CTU-UHB database freely available on the PhysioNet Website. Results show that both the progressive baseline and the parameterized deceleration episodes can describe different time-variant behaviour, whose characteristics and progression can help the observer to discriminate between normal and pathological FHR signal patterns. This opens perspectives for classification of non-reassuring CTG recordings as a sign of foetal acidemia.

  13. Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis

    DEFF Research Database (Denmark)

    Tsiara, Chrissa G; Nikolopoulos, Georgios K; Bagos, Pantelis G

    2012-01-01

    Abstract Several studies have reported the prognostic strength of HIV-1 DNA with variable results however. The aims of the current study were to estimate more accurately the ability of HIV-1 DNA to predict progression of HIV-1 disease toward acquired immunodeficiency syndrome (AIDS) or death...... of primary studies indicated that HIV-1 DNA was a significantly better predictor than HIV-1 RNA of either AIDS alone (ratio of RRs=1.47, 95% CI: 1.05-2.07) or of combined (AIDS or death) progression outcomes (ratio of RRs=1.51, 95% CI: 1.11-2.05). HIV-1 DNA is a strong predictor of HIV-1 disease progression...

  14. Engineering development of coal-fired high performance power systems, Phases 2 and 3. Quarterly progress report, October 1--December 31, 1996. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The goals of this program are to develop a coal-fired high performance power generation system (HIPPS) by the year 2000 that is capable of: {gt} 47% efficiency (HHV); NO{sub x}, SO{sub x}, and particulates {gt} 10% NSPS; coal providing {ge} 65% of heat input; all sold wastes benign; and cost of electricity 90% of present plant. Work reported herein is from Task 1.3 HIPPS Commercial Plant Design, Task 2,2 HITAF Air Heater, and Task 2.4 Duct Heater Design. The impact on cycle efficiency from the integration of various technology advances is presented. The criteria associated with a commercial HIPPS plant design as well as possible environmental control options are presented. The design of the HITAF air heaters, both radiative and convective, is the most critical task in the program. In this report, a summary of the effort associated with the radiative air heater designs that have been considered is provided. The primary testing of the air heater design will be carried out in the UND/EERC pilot-scale furnace; progress to date on the design and construction of the furnace is a major part of this report. The results of laboratory and bench scale activities associated with defining slag properties are presented. Correct material selection is critical for the success of the concept; the materials, both ceramic and metallic, being considered for radiant air heater are presented. The activities associated with the duct heater are also presented.

  15. Hawaii demand-side management resource assessment. Final report, Reference Volume 1: Building prototype analysis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report provides a detailed description of, and the baseline assumptions and simulation results for, the building prototype simulations conducted for the building types designated in the Work Plan for Demand-side Management Assessment of Hawaii`s Demand-Side Resources (HES-4, Phase 2). This report represents the second revision to the initial building prototype description report provided to DBEDT early in the project. Modifications and revisions to the prototypes, based on further calibration efforts and on comments received from DBEDT Staff have been incorporated into this final version. These baseline prototypes form the basis upon which the DSM measure impact estimates and the DSM measure data base were developed for this project. This report presents detailed information for each of the 17 different building prototypes developed for use with the DOE-21E program (23 buildings in total, including resorts and hotels defined separately for each island) to estimate the impact of the building technologies and measures included in this project. The remainder of this section presents some nomenclature and terminology utilized in the reports, tables, and data bases developed from this project to denote building type and vintage. Section 2 contains a more detailed discussion of the data sources, the definition of the residential sector building prototypes, and results of the DOE-2 analysis. Section 3 provides a similar discussion for the commercial sector. The prototype and baseline simulation results are presented in a separate section for each building type. Where possible, comparison of the baseline simulation results with benchmark data from the ENERGY 2020 model or other demand forecasting models specific to Hawaii is included for each building. Appendix A contains a detailed listing of the commercial sector baseline indoor lighting technologies included in the existing and new prototypes by building type.

  16. Integrated Data Collection Analysis (IDCA) Program - Final Review September 12, 2012 at DHS

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Phillips, Jason J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shelley, Timothy J. [Air Force Research Lab. (AFRL), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Tyndall AFB, FL (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2012-11-26

    The Integrated Data Collection Analysis (IDCA) program conducted a final program review at the Department of Homeland Security on September 12, 2012. The review was focused on the results of the program over the complete performance period. A summary presentation delineating the accomplished tasks started the meeting, followed by technical presentations on various issues that arose during the performance period. The presentations were completed with a statistical evaluation of the testing results from all the participants in the IDCA Proficiency Test study. The meeting closed with a discussion of potential sources of funding for continuing work to resolve some of these technical issues. This effort, funded by the Department of Homeland Security (DHS), put the issues of safe handling of these materials in perspective with standard military explosives. The study added Small-Scale Safety and Thermal (SSST) testing results for a broad suite of different HMEs to the literature, and suggested new guidelines and methods to develop safe handling practices for HMEs. Each participating testing laboratory used identical test materials and preparation methods wherever possible. Note, however, the test procedures differ among the laboratories. The results were compared among the laboratories and then compared to historical data from various sources. The testing performers involved were Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Naval Surface Warfare Center, Indian Head Division (NSWC IHD), Sandia National Laboratories (SNL), and Air Force Research Laboratory, Tyndall AFB (AFRL/RXQL). These tests were conducted as a proficiency study in order to establish some consistency in test protocols, procedures, and experiments and to compare results when these testing variables cannot be made consistent.

  17. The Fourth/Final-Year University Student Future Professional Career: Analysis of Factors and Personal Qualities

    Directory of Open Access Journals (Sweden)

    V. Lamanauskas

    2017-12-01

    Full Text Available Career management as a lifelong lasting process becomes very actual in today's modern society because of many reasons. The environment becomes turbulent, in a general sense; therefore, it is natural that career environment, basically, is chaotic as well. Nevertheless, career for many people is, undoubtedly, very important, because it is directly related to life quality. Professional activity satisfies almost all human needs: physiological, safety, social, attainment, self-realisation, independence, autonomy and other. The efficiency of the mentioned activity and the ability of the personality to construct his career are closely related things. Individual's career process studies are especially popular recently, because deeper career perception helps to understand the most important relations between man and work, career management and constant learning, helps not only to know man's abilities, but also the abilities to give oneself to modern environment, to understand career projection possibilities, to plan one's professional future. Seeking to analyse final-year university student position regarding career questions, a written form survey was carried out. The research was carried out between September 2015 and March 2016. The research sample (185 was structured applying a consecutive 'bunch' system. The respondents from three Lithuanian universities Klaipėda, Vilnius and Šiauliai, were selected in the sample. Professional career parameters were evaluated: career conception, the importance of work values and abilities, study influence, promoting and limiting factors and personal qualities. The research is grounded on a mixed strategy, when quantitative and qualitative research approach is combined. The obtained results, based on qualitative analysis, about professional personal career promoting and limiting factors and personal qualities are presented in this research.

  18. Annex D-200 Area Interim Storage Area Final Safety Analysis Report [FSAR] [Section 1 & 2

    Energy Technology Data Exchange (ETDEWEB)

    CARRELL, R D

    2002-07-16

    The 200 Area Interim Storage Area (200 Area ISA) at the Hanford Site provides for the interim storage of non-defense reactor spent nuclear fuel (SNF) housed in aboveground dry cask storage systems. The 200 Area ISA is a relatively simple facility consisting of a boundary fence with gates, perimeter lighting, and concrete and gravel pads on which to place the dry storage casks. The fence supports safeguards and security and establishes a radiation protection buffer zone. The 200 Area ISA is nominally 200,000 ft{sup 2} and is located west of the Canister Storage Building (CSB). Interim storage at the 200 Area ISA is intended for a period of up to 40 years until the materials are shipped off-site to a disposal facility. This Final Safety Analysis Report (FSAR) does not address removal from storage or shipment from the 200 Area ISA. Three different SNF types contained in three different dry cask storage systems are to be stored at the 200 Area ISA, as follows: (1) Fast Flux Test Facility Fuel--Fifty-three interim storage casks (ISC), each holding a core component container (CCC), will be used to store the Fast Flux Test Facility (FFTF) SNF currently in the 400 Area. (2) Neutron Radiography Facility (NRF) TRIGA'--One Rad-Vault' container will store two DOT-6M3 containers and six NRF TRIGA casks currently stored in the 400 Area. (3) Commercial Light Water Reactor Fuel--Six International Standards Organization (ISO) containers, each holding a NAC-I cask4 with an inner commercial light water reactor (LWR) canister, will be used for commercial LWR SNF from the 300 Area. An aboveground dry cask storage location is necessary for the spent fuel because the current storage facilities are being shut down and deactivated. The spent fuel is being transferred to interim storage because there is no permanent repository storage currently available.

  19. Final diagnosis in children with subclinical hypothyroidism and mutation analysis of the thyroid peroxidase gene (TPO).

    Science.gov (United States)

    Turkkahraman, Doga; Alper, Ozgul M; Aydin, Funda; Yildiz, Akin; Pehlivanoglu, Suray; Luleci, Guven; Akcurin, Sema; Bircan, Iffet

    2009-09-01

    To determine the final diagnosis of patients with subclinical hypothyroidism (SCH), and to perform mutation screening of the thyroid peroxidase gene (TPO). Infants with SCH without an identified etiology were included in the study. Patients with thyroid dysgenesis were excluded. Children > or = 2 years of age, and still on L-thyroxine (LT4) treatment underwent a diagnostic algorithm. After LT4 was discontinued for 4 weeks, thyroid function tests (TFT) were obtained. A perchlorate discharge test (PDT) was performed in patients with normal thyroid ultrasound but abnormal TFT. Sequence analysis of TPO was studied in all children who underwent a PDT. Forty-eight patients (23 males and 25 females) completed the trial. Among these children, 19 (39.5%) had transient SCH, and 29 (60.5%) had permanent SCH. Among patients with permanent SCH, 19 had thyroid hypoplasia, six had partial iodide organification defect with positive PDT, and four had other dyshormonogenesis with negative PDT. Mean LT4 dose before the medication ceased was 1.2 +/- 0.5 microg/kg/day in transient cases, and 1.7 +/- 0.4 in those with permanent SCH (p TPO mutation was detected. However, in five patients, seven different previously known TPO polymorphisms were detected: c.102C > G, L4L; > A, A576A; c.2088C > T, D666D; c.2263A > C, T725P; c.2630 T >C, V847A. LT4 treatment should be stopped after the age of 2 years in infants with SCH without a definite pathology of the thyroid gland to exclude cases with transient hypothyroidism. Additionally, we should consider particularly thyroid gland hypoplasia, and also partial defects in iodide organification in infants with SCH.

  20. [Psychological distress of children with progressive diseases and multiple disabilities: A crossed analysis].

    Science.gov (United States)

    Perifano, A; Scelles, R

    2015-09-01

    , distress, sadness, depression, stress, anger, and frustration. The family and caregivers responded by socializing with the child, providing him with comfort, assisting him in meeting his basic needs, administering medication, etc. Loneliness, disease-progression-related loss of abilities, physical pain, and epilepsy were the main factors of psychological distress. Three children were prescribed an antidepressant, two with an anticonvulsive effect. The results of this research depend on the difficulty making a distinction between physical and psychological pain and the interpretation of the child's relatives remains an imperfect translation of what the child feels. Further research to overcome these shortcomings is currently under consideration. Moreover, quantitative analysis is needed to make this research more robust. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  1. Chronic kidney disease progression: a retrospective analysis of 3-year adherence to a low protein diet.

    Science.gov (United States)

    Rizzetto, Felipe; Leal, Viviane de Oliveira; Bastos, Leonardo Soares; Fouque, Denis; Mafra, Denise

    2017-11-01

    The potential benefits and dangers of dietary protein restriction in chronic kidney disease (CKD) are still controversial. Thus, the aim of this study is to evaluate the effect of low protein diet (LPD) on the renal function in nondialysis CKD patients. A retrospective study was conducted from 321 nondialysis CKD patient's medical files (65.1 ± 12.7 yrs, 58.2% men). These patients received individualized dietary protein prescription (0.6-0.8 g protein/kg/day). Protein intake was evaluated by food diary and 24 h-food recall. Adherence to the LPD was considered when patients intake from 90 to 110% of the prescribed amount of protein. The patients were divided into 4 groups: (G1) adherent diabetes mellitus (DM) patients (n = 83); (G2) non-adherent DM patients (n = 106); (G3) adherent non-DM patients (n = 75); (G4) non-adherent non-DM patients (n = 57). Renal function was assessed by estimated glomerular filtration rate (eGFR). Both groups of patients (DM and non-DM) that adhered to the LPD showed significant improvement in eGFR (G1: 38.7 ± 13.2 mL/min to 51.1 ± 17.0 mL/min (p patients, no differences in albumin and BMI were observed at the end of follow up. In non-adherent patients, eGFR significantly decreased in DM group (G2: 44.2 ± 18.5 mL/min to 38.2 ± 15.8 mL/min (p = 0.003)). According to multivariate analysis, annual changes in eGFR were not independent associated with age, gender, BMI, lipid profile, bicarbonate or smoking status. In summary, adherence to low protein diet could be able to improve serum creatinine and eGFR, well-known markers of renal function. However, prospective studies are needed to control confounders which affect renal function and CKD progression.

  2. Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 1, Environmental Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    This is volume 1 of the final environmental impact statement of the Bonneville Power Administration Information is included on the following: Purpose of and need for action; alternatives including the proposed action; affected environment; and environmental consequences.

  3. ttH Analysis in 3 Leptons Final State at ATLAS

    CERN Document Server

    Wang, Chao; The ATLAS collaboration

    2017-01-01

    ATLAS Run2 operation has started since 2015 with the sqrt(s) =13TeV. The talk is to show a seraching of the Higgs production associated with top quarks pair in three leptons final states and the corresponding total Lumi is 13.2 fb-1. The estimation of the main background and final measred results are preseted. The latest study of the fakes with Matrix Method is also shown in this talk.

  4. Application of accident progression event tree technology to the Savannah River Site Defense Waste Processing Facility SAR analysis

    International Nuclear Information System (INIS)

    Brandyberry, M.D.; Baker, W.H.; Wittman, R.S.; Amos, C.N.

    1993-01-01

    The Accident Analysis in the Safety Analysis Report (SAR) for the Savannah River Site (SRS) Defense Waste Processing Facility (DWPF) has recently undergone an upgrade. Non-reactor SARs at SRS (and other Department of Energy (DOE) sites) use probabilistic techniques to assess the frequency of accidents at their facilities. This paper describes the application of an extension of the Accident Progression Event Tree (APET) approach to accidents at the SRS DWPF. The APET technique allows an integrated model of the facility risk to be developed, where previous probabilistic accident analyses have been limited to the quantification of the frequency and consequences of individual accident scenarios treated independently. Use of an APET allows a more structured approach, incorporating both the treatment of initiators that are common to more than one accident, and of accident progression at the facility

  5. Fukushima Daiichi Unit 1 Uncertainty Analysis-Exploration of Core Melt Progression Uncertain Parameters-Volume II.

    Energy Technology Data Exchange (ETDEWEB)

    Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brooks, Dusty Marie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    Sandia National Laboratories (SNL) has conducted an uncertainty analysi s (UA) on the Fukushima Daiichi unit (1F1) accident progression wit h the MELCOR code. Volume I of the 1F1 UA discusses the physical modeling details and time history results of the UA. Volume II of the 1F1 UA discusses the statistical viewpoint. The model used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). The goal of this work was to perform a focused evaluation of uncertainty in core damage progression behavior and its effect on key figures - of - merit (e.g., hydrogen production, fraction of intact fuel, vessel lower head failure) and in doing so assess the applicability of traditional sensitivity analysis techniques .

  6. Analysis of the progression of fibroepithelial tumours of the breast by PCR-based clonality assay

    NARCIS (Netherlands)

    Kuijper, Arno; Buerger, H.; Simon, R.; Schaefer, K-L.; Croonen, A.; Boecker, W.; Wall, E. van der; Diest, P.J. van

    2002-01-01

    Fibroadenoma and phyllodes tumour of the breast are both fibroepithelial tumours. Although progression to epithelial malignancy has been described, the behaviour of most fibroadenomas is benign. Phyllodes tumours, on the other hand, can display locally destructive growth and can even metastasize. A

  7. Analysis of the BEV Technology Progress of America, Europe, Japan and Korea Based on Patent Map

    Science.gov (United States)

    Yurong, Huang; Yuanyuan, Hou; Jingyan, Zhou; Ru, Liu

    2018-02-01

    The paper analyzed the Battery Electric Vehicle patent application trend, major country distribution, main technology layout and patentee of America, Europe, Japan and Korea based on patent information from 2006 to 2016 by using patent map method, and visualized the Battery Electric Vehicle technology progress conditions of the four countries and regions in the last decade.

  8. Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration:Case report and review

    Directory of Open Access Journals (Sweden)

    Paulo Roberto de Brito-Marques

    Full Text Available Abstract Objective: To investigate progressive non-fluent aphasia and histopathologically-proven corticobasal degeneration. Methods: We evaluated symptoms, signs, neuropsychological deficits, and radiology data longitudinally, in a patient with autopsy-proven corticobasal degeneration and correlated these observations directly to the neuroanatomic distribution of the disease. Results: At presentation, a specific pattern of cognitive impairment was evident with an extreme extrapyramidal motor abnormality. Follow-up examination revealed persistent impairment of praxis and executive functioning, progressive worsening of language performance, and moderately preserved memory. The motor disorder manifested and worsened as the condition progressed. Many of the residual nerve cells were ballooned and achromatic with eccentric nuclei. Tau-immunoreactive pathology was significantly more prominent in neurons in the frontal and parietal cortices and dentate nuclei than in temporal neocortex, hippocampi and brainstem. Conclusion: The clinical diagnosis of progressive non-fluent aphasia secondary to corticobasal degeneration hinged on a specific pattern of impaired cognition as well as an extrapyramidal motor disorder, reflecting the neuroanatomic distribution of the disease in frontal and anterior temporal cortices and the dentate nuclei.

  9. Clinicopathologic analysis of progressive non-fluent aphasia and corticobasal degeneration: Case report and review.

    Science.gov (United States)

    de Brito-Marques, Paulo Roberto; Vieira-Mello, Roberto José; Montenegro, Luciano; Aragão, Maria de Fátima Vasco

    2011-01-01

    To investigate progressive non-fluent aphasia and histopathologically-proven corticobasal degeneration. We evaluated symptoms, signs, neuropsychological deficits, and radiology data longitudinally, in a patient with autopsy-proven corticobasal degeneration and correlated these observations directly to the neuroanatomic distribution of the disease. At presentation, a specific pattern of cognitive impairment was evident with an extreme extrapyramidal motor abnormality. Follow-up examination revealed persistent impairment of praxis and executive functioning, progressive worsening of language performance, and moderately preserved memory. The motor disorder manifested and worsened as the condition progressed. Many of the residual nerve cells were ballooned and achromatic with eccentric nuclei. Tau-immunoreactive pathology was significantly more prominent in neurons in the frontal and parietal cortices and dentate nuclei than in temporal neocortex, hippocampi and brainstem. The clinical diagnosis of progressive non-fluent aphasia secondary to corticobasal degeneration hinged on a specific pattern of impaired cognition as well as an extrapyramidal motor disorder, reflecting the neuroanatomic distribution of the disease in frontal and anterior temporal cortices and the dentate nuclei.

  10. Progressivity, horizontal equity and reranking in health care finance: a decomposition analysis for the Netherlands

    NARCIS (Netherlands)

    A. Wagstaff (Adam); E.K.A. van Doorslaer (Eddy)

    1997-01-01

    textabstractThis paper employs the method of Aronson et al. (1994) to decompose the redistributive effect of the Dutch health care financing system into three components: a progressivity component, a classical horizontal equity component and a reranking component. Results are presented for the

  11. The Learning Organization: Tracking Progress in a Developing Country--A Comparative Analysis Using the DLOQ

    Science.gov (United States)

    Jamali, Dima; Sidani, Yusuf; Zouein, Charbel

    2009-01-01

    Purpose: The purpose of this paper is to survey the various measurement instruments of the learning organization on offer, leading to the adoption of a tool that was considered most suitable for gauging progress towards the learning organization in two sectors of the Lebanese economy, namely banking and information technology (IT).…

  12. Multifactorial analysis of factors associated with the incidence and progression of erosive tooth wear

    NARCIS (Netherlands)

    El Aidi, H.; Bronkhorst, E.M.; Huysmans, M.C.D.N.J.M.; Truin, G.J.

    2011-01-01

    To prevent erosive tooth wear, early diagnosis and identification of causative factors are essential. The aim of the present 3-year longitudinal study was to investigate the association between a broad collection of biological and behavioural factors and the incidence and progression of erosive

  13. Proteomic analysis of differential protein expression in human atherosclerotic plaque progression

    NARCIS (Netherlands)

    Donners, Marjo M. P. C.; Verluyten, Monique J.; Bouwman, Freek G.; Mariman, Edwin C. M.; Devreese, Bart; Vanrobaeys, Frank; van Beeumen, Jozef; van den Akker, Luc H. J. M.; Daemen, Mat J. A. P.; Heeneman, Sylvia

    2005-01-01

    In this study, differential protein expression was assessed during human atherosclerotic plaque progression. A multifaceted approach was used in which differential protein expression was studied by two-dimensional (2D) gel electrophoresis and validated in individual patients using western blotting

  14. Comprehensive analysis of the achromatopsia genes CNGA3 and CNGB3 in progressive cone dystrophy.

    NARCIS (Netherlands)

    Thiadens, A.A.H.J.; Roosing, S.; Collin, R.W.J.; Moll-Ramirez, N. van; Lith-Verhoeven, J.J. van; Schooneveld, M.J. van; Hollander, A.I. den; Born, L.I. van den; Hoyng, C.B.; Cremers, F.P.M.; Klaver, C.C.

    2010-01-01

    OBJECTIVE: To investigate whether the major achromatopsia genes (CNGA3 and CNGB3) play a role in the cause of progressive cone dystrophy (CD). DESIGN: Prospective multicenter study. PARTICIPANTS: Probands (N = 60) with autosomal recessive (ar) CD from various ophthalmogenetic clinics in The

  15. Comprehensive analysis of the achromatopsia genes CNGA3 and CNGB3 in progressive cone dystrophy

    NARCIS (Netherlands)

    Thiadens, Alberta A. H. J.; Roosing, Susanne; Collin, Rob W. J.; van Moll-Ramirez, Norka; van Lith-Verhoeven, Janneke J. C.; van Schooneveld, Mary J.; den Hollander, Anneke I.; van den Born, L. Ingeborgh; Hoyng, Carel B.; Cremers, Frans P. M.; Klaver, Caroline C. W.

    2010-01-01

    To investigate whether the major achromatopsia genes (CNGA3 and CNGB3) play a role in the cause of progressive cone dystrophy (CD). Prospective multicenter study. Probands (N = 60) with autosomal recessive (ar) CD from various ophthalmogenetic clinics in The Netherlands. All available ophthalmologic

  16. A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry

    OpenAIRE

    Zunder, Eli R.; Lujan, Ernesto; Goltsev, Yury; Wernig, Marius; Nolan, Garry P.

    2015-01-01

    To analyze cellular reprogramming at the single-cell level, mass cytometry was used to simultaneously measure markers of pluripotency, differentiation, cell-cycle status, and cellular signaling throughout the reprogramming process. Time-resolved progression analysis of the resulting data sets was used to construct a continuous molecular roadmap for three independent reprogramming systems. Although these systems varied substantially in Oct4, Sox2, Klf4, and c-Myc stoichiometry, they presented ...

  17. Analysis of progressive distorsion. Validation of the method based on effective primary stress. Discussion of Anderson's experimental data

    International Nuclear Information System (INIS)

    Moulin, Didier.

    1981-02-01

    An empirical rule usable for design by analysis against progressive distorsion has been set up from experiments conducted in C.E.N. Saclay. This rule is checked with experimental data obtained by W.F. ANDERSON, this experiment is sufficiently different from the Saclay one to evaluate the merits of the rule. The satisfactory results achieved, are another validation of the efficiency diagram on which the method is based [fr

  18. Tracking progress towards global drinking water and sanitation targets: A within and among country analysis.

    Science.gov (United States)

    Fuller, James A; Goldstick, Jason; Bartram, Jamie; Eisenberg, Joseph N S

    2016-01-15

    Global access to safe drinking water and sanitation has improved dramatically during the Millennium Development Goal (MDG) period. However, there is substantial heterogeneity in progress between countries and inequality within countries. We assessed countries' temporal patterns in access to drinking water and sanitation using publicly available data. We then classified countries using non-linear modeling techniques as having one of the following trajectories: 100% coverage, linear growth, linear decline, no change, saturation, acceleration, deceleration, negative acceleration, or negative deceleration. We further assessed the degree to which temporal profiles follow a sigmoidal pattern and how these patterns might vary within a given country between rural and urban settings. Among countries with more than 10 data points, between 15% and 38% showed a non-linear trajectory, depending on the indicator. Overall, countries' progress followed a sigmoidal trend, but some countries are making better progress and some worse progress than would be expected. We highlight several countries that are not on track to meet the MDG for water or sanitation, but whose access is accelerating, suggesting better performance during the coming years. Conversely, we also highlight several countries that have made sufficient progress to meet the MDG target, but in which access is decelerating. Patterns were heterogeneous and non-linearity was common. Characterization of these heterogeneous patterns will help policy makers allocate resources more effectively. For example, policy makers can identify countries that could make use of additional resources or might be in need of additional institutional capacity development to properly manage resources; this will be essential to meet the forthcoming Sustainable Development Goals. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Final Report: Optimal Model Complexity in Geological Carbon Sequestration: A Response Surface Uncertainty Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ye [Univ. of Wyoming, Laramie, WY (United States)

    2018-01-17

    equivalency, all the stratigraphic models were successfully upscaled from the reference heterogeneous model for bulk flow and transport predictions (Zhang & Zhang, 2015). GCS simulation was then simulated with all models, yielding insights into the level of parameterization complexity that is needed for the accurate simulation of reservoir pore pressure, CO2 storage, leakage, footprint, and dissolution over both short (i.e., injection) and longer (monitoring) time scales. Important uncertainty parameters that impact these key performance metrics were identified for the stratigraphic models as well as for the heterogeneous model, leading to the development of reduced/simplified models at lower characterization cost that can be used for the reservoir uncertainty analysis. All the CO2 modeling was conducted using PFLOTRAN – a massively parallel, multiphase, multi-component, and reactive transport simulator developed by a multi-laboratory DOE/SciDAC (Scientific Discovery through Advanced Computing) project (Zhang et al., 2017, in review). Within the uncertainty analysis framework, increasing reservoir depth were investigated to explore its effect on the uncertainty outcomes and the potential for developing gravity-stable injection with increased storage security (Dai et al., 20126; Dai et al., 2017, in review). Finally, to accurately model CO2 fluid-rock reactions and resulting long-term storage as secondary carbonate minerals, a modified kinetic rate law for general mineral dissolution and precipitation was proposed and verified that is invariant to a scale transformation of the mineral formula weight. This new formulation will lead to more accurate assessment of mineral storage over geologic time scales (Lichtner, 2016).

  20. Progression of biopsy-measured liver fibrosis in untreated patients with hepatitis C infection: non-Markov multistate model analysis.

    Directory of Open Access Journals (Sweden)

    Peter Bacchetti

    Full Text Available BACKGROUND: Fibrosis stages from liver biopsies reflect liver damage from hepatitis C infection, but analysis is challenging due to their ordered but non-numeric nature, infrequent measurement, misclassification, and unknown infection times. METHODS: We used a non-Markov multistate model, accounting for misclassification, with multiple imputation of unknown infection times, applied to 1062 participants of whom 159 had multiple biopsies. Odds ratios (OR quantified the estimated effects of covariates on progression risk at any given time. RESULTS: Models estimated that progression risk decreased the more time participants had already spent in the current stage, African American race was protective (OR 0.75, 95% confidence interval 0.60 to 0.95, p = 0.018, and older current age increased risk (OR 1.33 per decade, 95% confidence interval 1.15 to 1.54, p = 0.0002. When controlled for current age, older age at infection did not appear to increase risk (OR 0.92 per decade, 95% confidence interval 0.47 to 1.79, p = 0.80. There was a suggestion that co-infection with human immunodeficiency virus increased risk of progression in the era of highly active antiretroviral treatment beginning in 1996 (OR 2.1, 95% confidence interval 0.97 to 4.4, p = 0.059. Other examined risk factors may influence progression risk, but evidence for or against this was weak due to wide confidence intervals. The main results were essentially unchanged using different assumed misclassification rates or imputation of age of infection. DISCUSSION: The analysis avoided problems inherent in simpler methods, supported the previously suspected protective effect of African American race, and suggested that current age rather than age of infection increases risk. Decreasing risk of progression with longer time already spent in a stage was also previously found for post-transplant progression. This could reflect varying disease activity, with recent progression indicating

  1. Drivers of inequality in Millennium Development Goal progress: a statistical analysis.

    Directory of Open Access Journals (Sweden)

    David Stuckler

    2010-03-01

    Full Text Available Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs. We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of available domestic funds, or health system infrastructure. We also examined the impact of joint epidemics of HIV/AIDS and noncommunicable diseases (NCDs, which may limit the ability of households to address child mortality and increase risks of infectious diseases.We calculated each country's distance from its MDG goals for HIV/AIDS, tuberculosis, and infant and child mortality targets for the year 2005 using the United Nations MDG database for 227 countries from 1990 to the present. We studied the association of economic development (gross domestic product [GDP] per capita in purchasing-power-parity, the relative priority placed on health (health spending as a percentage of GDP, real health spending (health system expenditures in purchasing-power-parity, HIV/AIDS burden (prevalence rates among ages 15-49 y, and NCD burden (age-standardised chronic disease mortality rates, with measures of distance from attainment of health MDGs. To avoid spurious correlations that may exist simply because countries with high disease burdens would be expected to have low MDG progress, and to adjust for potential confounding arising from differences in countries' initial disease burdens, we analysed the variations in rates of change in MDG progress versus expected rates for each country. While economic development, health priority, health spending, and health infrastructure did not explain more than one-fifth of the differences in progress to health MDGs among countries, burdens of HIV and NCDs explained more than half of between-country inequalities in child mortality progress (R(2-infant mortality = 0.57, R(2-under 5 mortality = 0.54. HIV/AIDS and NCD burdens were

  2. Drivers of inequality in Millennium Development Goal progress: a statistical analysis.

    Science.gov (United States)

    Stuckler, David; Basu, Sanjay; McKee, Martin

    2010-03-02

    Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs). We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of available domestic funds), or health system infrastructure. We also examined the impact of joint epidemics of HIV/AIDS and noncommunicable diseases (NCDs), which may limit the ability of households to address child mortality and increase risks of infectious diseases. We calculated each country's distance from its MDG goals for HIV/AIDS, tuberculosis, and infant and child mortality targets for the year 2005 using the United Nations MDG database for 227 countries from 1990 to the present. We studied the association of economic development (gross domestic product [GDP] per capita in purchasing-power-parity), the relative priority placed on health (health spending as a percentage of GDP), real health spending (health system expenditures in purchasing-power-parity), HIV/AIDS burden (prevalence rates among ages 15-49 y), and NCD burden (age-standardised chronic disease mortality rates), with measures of distance from attainment of health MDGs. To avoid spurious correlations that may exist simply because countries with high disease burdens would be expected to have low MDG progress, and to adjust for potential confounding arising from differences in countries' initial disease burdens, we analysed the variations in rates of change in MDG progress versus expected rates for each country. While economic development, health priority, health spending, and health infrastructure did not explain more than one-fifth of the differences in progress to health MDGs among countries, burdens of HIV and NCDs explained more than half of between-country inequalities in child mortality progress (R(2)-infant mortality = 0.57, R(2)-under 5 mortality = 0.54). HIV/AIDS and NCD burdens were also

  3. Intelligent distributed control for nuclear power plants. Final (third annual) technical progress report, September 1991--June 1993 (September 1989--June 1993): Includes no-cost extension period from September 1992--June 1993

    Energy Technology Data Exchange (ETDEWEB)

    Klevans, E.H.

    1993-12-31

    This project was initiated in September 1989 as a three year project to develop and demonstrate Intelligent Distributed Control (IDC) for Nuclear Power Plants. There were two primary goals of this research project. The first goal was to combine diagnostics and control to achieve a highly automated power plant as described by M.A. Schultz. The second goal was to apply this research to develop a prototype demonstration on an actual power plant system, the EBR-2 steam plant. Described in this Final (Third Annual) Technical Progress Report is the accomplishment of the project`s final milestone, an in-plant intelligent control experiment conducted on April 1, 1993. The development of the experiment included: simulation validation, experiment formulation and final programming, procedure development and approval, and experimental results. Other third year developments summarized in this report are: (1) a theoretical foundation for Reconfigurable Hybrid Supervisory Control, (2) a steam plant diagnostic system, (3) control console design tools and (4) other advanced and intelligent control.

  4. Mastoidectomy performance assessment of virtual simulation training using final-product analysis.

    Science.gov (United States)

    Andersen, Steven A W; Cayé-Thomasen, Per; Sørensen, Mads S

    2015-02-01

    The future development of integrated automatic assessment in temporal bone virtual surgical simulators calls for validation against currently established assessment tools. This study aimed to explore the relationship between mastoidectomy final-product performance assessment in virtual simulation and traditional dissection training. Prospective trial with blinding. A total of 34 novice residents performed a mastoidectomy on the Visible Ear Simulator and on a cadaveric temporal bone. Two blinded senior otologists assessed the final-product performance using a modified Welling scale. The simulator gathered basic metrics on time, steps, and volumes in relation to the on-screen tutorial and collisions with vital structures. Substantial inter-rater reliability (kappa = 0.77) for virtual simulation and moderate inter-rater reliability (kappa = 0.59) for dissection final-product assessment was found. The simulation and dissection performance scores had significant correlation (P = .014). None of the basic simulator metrics correlated significantly with the final-product score except for number of steps completed in the simulator. A modified version of a validated final-product performance assessment tool can be used to assess mastoidectomy on virtual temporal bones. Performance assessment of virtual mastoidectomy could potentially save the use of cadaveric temporal bones for more advanced training when a basic level of competency in simulation has been achieved. NA. © 2014 The American Laryngological, Rhinological and Otological Society, Inc.

  5. Mastoidectomy performance assessment of virtual simulation training using final-product analysis

    DEFF Research Database (Denmark)

    Andersen, Steven A W; Cayé-Thomasen, Per; Sørensen, Mads S

    2015-01-01

    in virtual simulation and traditional dissection training. STUDY DESIGN: Prospective trial with blinding. METHODS: A total of 34 novice residents performed a mastoidectomy on the Visible Ear Simulator and on a cadaveric temporal bone. Two blinded senior otologists assessed the final-product performance using...... version of a validated final-product performance assessment tool can be used to assess mastoidectomy on virtual temporal bones. Performance assessment of virtual mastoidectomy could potentially save the use of cadaveric temporal bones for more advanced training when a basic level of competency......OBJECTIVES/HYPOTHESIS: The future development of integrated automatic assessment in temporal bone virtual surgical simulators calls for validation against currently established assessment tools. This study aimed to explore the relationship between mastoidectomy final-product performance assessment...

  6. Studies of transport pathways of Th, U, rare earths, Ra-228, and Ra-226 from soil to plants and farm animals: Final progress report, 1983-1988

    Energy Technology Data Exchange (ETDEWEB)

    Linsalata, P

    1988-07-01

    This report consists of three parts. Part 1 discusses a field study conducted in an area of enhanced, natural radioactivity to assess the soil to edible vegetable concentration ratios (CR = concentration in dry vegetable/concentration in dry soil) of Th-232, Th-230, Ra-226, Ra-228, and the light rare earth elements (REE's), La, Ce, and Nd. Twenty-eight soil, and approximately 42 vegetable samples consisting of relatively equal numbers of seven varieties, were obtained from 11 farms on the Pocos de Caldas Plateau in the state of Minas Gerais, Brazil. This region is the site of a major natural analogue study to assess the mobilization and retardation processes affecting thorium and the REE's at the Morro do Ferro ore body, and uranium series radionuclides at the Osamu Utsumi open pit uranium mine. Thorium (IV) serves as a chemical analogue for quadrivalent plutonium, the light REE's (III) as chemical analogues for trivalent americium and curium, and uranium (VI) as an analogue for transuranics with stable oxidation states above IV, e.g., Pu(VI). Part 2 includes our final measurement results for naturally occurring light rare earth elements (REE's include La, Ce, Nd, and SM), U-series and Th-series radionuclides in adult farm animal tissues, feeds and soils. Our findings on soil-to-tissue concentration ratios (CR's) and the comparative behavior of these elements in farm animals raised under natural conditions by local farmers are presented. Part 3 summarizes our findings to date on the distribution and mobilization of Th-232, light rare earth elements (LREE), U-238 and Ra-228 in the MF basin. Estimates of first order, present day, mobilization rate constants resulting from ground water solubilization and seepage/stream transport are calculated using revised inventory estimates for the occurrence of these elements in the ore body and annual flux estimates for the transport of these elements away from the ore body. 151 refs., 20 figs., 40 tabs.

  7. Wind energy mission analysis. Final report, appendices A--J. [USA

    Energy Technology Data Exchange (ETDEWEB)

    1977-02-18

    Information is presented concerning meteorological data and supporting analyses, gross energy consumption patterns and end-use analysis, analysis for industrial applications of wind energy conversion systems (WECS), analysis for residential applications of WECS, analysis for application of WECS to communities remote from utility grids, analysis for agricultural applications of WECS, regional evaluation of the economics of wind turbine generation to the U. S. electric utility district, impact of storage on WECS, financial analysis techniques, and system spacing.

  8. A methodology for the analysis of damage progression in rubble mound breakwaters

    OpenAIRE

    Campos Duque, Álvaro

    2016-01-01

    Nowadays, risk based designs as well as reliable rehabilitation and maintenance strategies are essential when dealing with coastal structures. In this sense, the probability of failure due to instability of the armour layer is one of the main issues in rubble mound breakwaters, and so is improving the knowledge on its deterioration rate. Both stability and damage progression on rubble mound breakwaters have been studied for more than 80 years, using different approaches, under regular/irregul...

  9. Total RNA Sequencing Analysis of DCIS Progressing to Invasive Breast Cancer

    Science.gov (United States)

    2017-09-01

    collaboration with Affymetrix scientists , we were able to determine Q/C measures that are predictive of subsequent array data quality, but at the cost... fact progress to invasive disease (IBC), and complements our multi-institutional, NIH-funded study of genetic and epigenetic alterations of pre...information we are seeking, because only the strongest signals were detectable in our data. In collaboration with Affymetrix scientists , we were able to

  10. Total RNA Sequencing Analysis of DCIS Progressing to Invasive Breast Cancer

    Science.gov (United States)

    2016-09-01

    for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT: This project is designed to complement a multi-institutional, NIH...the minority of cases of preinvasive breast cancer (DCIS), that do in fact progress to invasive disease (IBC), and complements our multi-institutional...Pathology & Laboratory Medicine Lineberger Comprehensive Cancer Center 125 Mason Farm Road The University of North Carolina at Chapel Hill Chapel

  11. Acoustical analysis of Canadian French word-final vowels in varying phonetic contexts.

    Science.gov (United States)

    Law, Franzo; Strange, Winifred

    2015-07-01

    This study analyzed Canadian French (CF) vowels /i y ø e ɛ o u a/ in word-final position. Of particular interest was the stability of /e-ɛ/; although some dialects of French have merged /e-ɛ/ to /e/ in word-final context, this contrast is maintained in CF. The present study investigated the stability of this contrast in various preceding phonetic contexts and in lexical vs morphological contrasts. Results showed that the contrast was maintained by all four speakers, although to varying degrees.

  12. Modeling, analysis and experiments for fusion nuclear technology: FNT progress report: Modeling and FINESSE

    International Nuclear Information System (INIS)

    Abdou, M.A.; Tillack, M.S.; Raffray, A.R.

    1987-01-01

    This document is a progress report on two technical studies carried out during 1986, both of which relate to the implementation phase of FNT. The first, which is a follow-up to FINESSE, focuses on specific key questions for: (1) very near-term (0 to 3 years) non-fusion experiments and facilities, and (2) FNT testing in a fusion facility. The second is the initial stage of a detailed effort to develop theory, models and computer codes for predicting the performance of nuclear components. Chapters are presented on (1) introduction and chapter summaries, (2) non-fusion experiments and facilities, (3) fusion testing issues, and (4) theory and modeling. Chapter 2 is an assessment of the relative advantages of many solid breeders, neutron multipliers and configurations. Various issues affecting design and cost of the blanket are examined in Chapter 3. Chapter 4 reports on the progress of the initial stage of an effort to develop theory and analytical and numerical models for nuclear components. A major part of the effort has focused on modeling of MHD effects for liquid metal blankets. Progress has also been made on modeling tritium transport and inventory in solid breeder blankets and the thermomechanical behavior of liquid-metal-cooled limiters

  13. Transfers from intensive care unit to hospital ward: a multicentre textual analysis of physician progress notes.

    Science.gov (United States)

    Brown, Kyla N; Leigh, Jeanna Parsons; Kamran, Hasham; Bagshaw, Sean M; Fowler, Rob A; Dodek, Peter M; Turgeon, Alexis F; Forster, Alan J; Lamontagne, Francois; Soo, Andrea; Stelfox, Henry T

    2018-01-28

    Little is known about documentation during transitions of patient care between clinical specialties. Therefore, we examined the focus, structure and purpose of physician progress notes for patients transferred from the intensive care unit (ICU) to hospital ward to identify opportunities to improve communication breaks. This was a prospective cohort study in ten Canadian hospitals. We analyzed physician progress notes for consenting adult patients transferred from a medical-surgical ICU to hospital ward. The number, length, legibility and content of notes was counted and compared across care settings using mixed-effects linear regression models accounting for clustering within hospitals. Qualitative content analyses were conducted on a stratified random sample of 32 patients. A total of 447 patient medical records that included 7052 progress notes (mean 2.1 notes/patient/day 95% CI 1.9-2.3) were analyzed. Notes written by the ICU team were significantly longer than notes written by the ward team (mean lines of text 21 vs. 15, p notes; mean agreement of patient issues was 42% [95% CI 31-53%]. Qualitative analyses identified eight themes related to focus (central point - e.g., problem list), structure (organization, - e.g., note-taking style), and purpose (intention - e.g., documentation of patient course) of the notes that varied across clinical specialties and physician seniority. Important gaps and variations in written documentation during transitions of patient care between ICU and hospital ward physicians are common, and include discrepancies in documentation of patient information.

  14. Systematic analysis of factors associated with progression and regression of ulcerative colitis in 918 patients.

    Science.gov (United States)

    Safroneeva, E; Vavricka, S; Fournier, N; Seibold, F; Mottet, C; Nydegger, A; Ezri, J; Straumann, A; Rogler, G; Schoepfer, A M

    2015-09-01

    Studies that systematically assess change in ulcerative colitis (UC) extent over time in adult patients are scarce. To assess changes in disease extent over time and to evaluate clinical parameters associated with this change. Data from the Swiss IBD cohort study were analysed. We used logistic regression modelling to identify factors associated with a change in disease extent. A total of 918 UC patients (45.3% females) were included. At diagnosis, UC patients presented with the following disease extent: proctitis [199 patients (21.7%)], left-sided colitis [338 patients (36.8%)] and extensive colitis/pancolitis [381 (41.5%)]. During a median disease duration of 9 [4-16] years, progression and regression was documented in 145 patients (15.8%) and 149 patients (16.2%) respectively. In addition, 624 patients (68.0%) had a stable disease extent. The following factors were identified to be associated with disease progression: treatment with systemic glucocorticoids [odds ratio (OR) 1.704, P = 0.025] and calcineurin inhibitors (OR: 2.716, P = 0.005). No specific factors were found to be associated with disease regression. Over a median disease duration of 9 [4-16] years, about two-thirds of UC patients maintained the initial disease extent; the remaining one-third had experienced either progression or regression of the disease extent. © 2015 John Wiley & Sons Ltd.

  15. Investigating the usefulness of a cluster-based trend analysis to detect visual field progression in patients with open-angle glaucoma.

    Science.gov (United States)

    Aoki, Shuichiro; Murata, Hiroshi; Fujino, Yuri; Matsuura, Masato; Miki, Atsuya; Tanito, Masaki; Mizoue, Shiro; Mori, Kazuhiko; Suzuki, Katsuyoshi; Yamashita, Takehiro; Kashiwagi, Kenji; Hirasawa, Kazunori; Shoji, Nobuyuki; Asaoka, Ryo

    2017-12-01

    To investigate the usefulness of the Octopus (Haag-Streit) EyeSuite's cluster trend analysis in glaucoma. Ten visual fields (VFs) with the Humphrey Field Analyzer (Carl Zeiss Meditec), spanning 7.7 years on average were obtained from 728 eyes of 475 primary open angle glaucoma patients. Mean total deviation (mTD) trend analysis and EyeSuite's cluster trend analysis were performed on various series of VFs (from 1st to 10th: VF1-10 to 6th to 10th: VF6-10). The results of the cluster-based trend analysis, based on different lengths of VF series, were compared against mTD trend analysis. Cluster-based trend analysis and mTD trend analysis results were significantly associated in all clusters and with all lengths of VF series. Between 21.2% and 45.9% (depending on VF series length and location) of clusters were deemed to progress when the mTD trend analysis suggested no progression. On the other hand, 4.8% of eyes were observed to progress using the mTD trend analysis when cluster trend analysis suggested no progression in any two (or more) clusters. Whole field trend analysis can miss local VF progression. Cluster trend analysis appears as robust as mTD trend analysis and useful to assess both sectorial and whole field progression. Cluster-based trend analyses, in particular the definition of two or more progressing cluster, may help clinicians to detect glaucomatous progression in a timelier manner than using a whole field trend analysis, without significantly compromising specificity. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  16. Analysis of final year DVM research projects submitted to the Faculty ...

    African Journals Online (AJOL)

    This study analyzed the intellectual output of the undergraduate final year students. research projects submitted to the Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, from 1994 to 2004. The findings of the study show that a total of 194 research projects were produced within the period under study.

  17. Analysis of final year DVM research projects submitted to the Faculty ...

    African Journals Online (AJOL)

    Central Research Laboratory

    This study analyzed the intellectual output of the undergraduate final year students‟ research projects submitted to the Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, from 1994 to 2004. The findings of the study show that a total of 194 research projects were produced within the period under study.

  18. How clean are Europe's cars? An analysis of carmaker progress towards EU CO2 targets in 2009

    Energy Technology Data Exchange (ETDEWEB)

    Dings, J. (ed.)

    2010-11-15

    This report is the fifth T and E has published on the annual progress Europe's major car manufacturers have made in reducing CO2 emissions and fuel consumption of new cars. The main purpose of these reports is to assess the progress that major car manufacturers in Europe are making towards cutting the average CO2 emissions of their products. We also assess how each carmaker is positioned to hit the mandatory CO2 standards that the European Union has set for 2015. In this year's report, we add an analysis showing to what extent the CO2 reductions achieved can be attributed to the financial crisis i.e. sales of cheaper, smaller cars, and to what extent to technological improvements.

  19. Coagulation Parameters and Risk of Progressive Hemorrhagic Injury after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Danfeng Zhang

    2015-01-01

    Full Text Available Intracranial hemorrhage (ICH after traumatic brain injury (TBI commonly increases in size and coagulopathy has been implicated in such progression. Our aim is to perform a meta-analysis to assess their relationship. Cochrane library, PubMed, and EMBASE were searched for literatures. Pooled effect sizes and 95% confidential intervals (CIs were calculated using random-effects model. We included six studies, involving 1700 participants with 540 progressive hemorrhagic injuries (PHIs. Our findings indicate that PT, D-dimer level, and INR value are positively associated with the risk of PHI. Higher level of PLT and Fg seemed to suggest a lower risk of PHI. Among these parameters, higher D-dimer level and INR value would possess more powerful strength in predicting PHI.

  20. Areas of progress towards a factor 4 territorial coherence scheme. Which local levers for a post-carbon conurbation? Final report - Scenario 2020-2030

    International Nuclear Information System (INIS)

    Beauvais, Jean Marie; Metais, Benedicte; Baratier, Jerome; Vidalenc, Eric

    2011-01-01

    Taking the Tours conurbation as an example, this study examines how to elaborate and define a new territorial coherence scheme (a land and urban planning tool) which would include a planned reduction of greenhouse gas emissions by a factor 4 between 2020 and 2030. It is therefore a prospective study with 2006 as a reference year (reductions are assessed with respect to 2006 due to data availability). After an analysis of the reference situation (2006) and of objectives, the report presents the scenario for 2020-2030, analyses the various levers in different sectors (mobility, housing, office building, industry and construction, agriculture), and examines possibilities related to the production of renewable energy, the adaptation to climate change, the creation of a new governance to mitigate and to adapt to climate change. Expected gains are discussed for transports, housing, office building, industry, agriculture, renewable energies, and adaptation. The last part reports a sensitive approach to a post-carbon world through different workshops (with children or within a fiction writing workshop)

  1. Using a profiling process to insure program quality: Volume II - support materials. Final progress report, May 15, 1991--November 14, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Kaser, J.S.; Roody, D.S.; Raizen, S.A.

    1996-11-01

    Between 1990 and 1995 the U.S. Department of Energy (DOE) and the National Center for Improving Science Education (National Center) developed a system for ongoing evaluation of K-12 educational programs in the DOE-supported national energy Laboratories. As part of the formative evaluation component of this collaborative endeavor, field staff in the Laboratories began creating profiles of their programs. However, many individuals within DOE Headquarters were not familiar with this profiling process and were unprepared to use the valuable information that the profiles generated. This manual was produced to orient Headquarters staff to profiling. It focuses on how Headquarters staff can use the profiling process to help their funded programs establish and/or maintain high quality. Its purpose, then, is not to train Headquarters staff to become proficient in profiling, but to show them how to draw on the Laboratories` use of profiling to bring about program improvement. Profiling is the process of systematically examining and describing a program`s elements against a set of components that define Effective Practice. The instrument used to capture the data for analysis is called a template, and most of this manual focuses on the templates and how to read and interpret them. However, since it is important to understand these data in context, the authors also describe what should accompany each template in a complete profiling packet and offer guidelines for reviewing complete packets and providing feedback to program managers. This document consists of Support Materials for the manual: exercise answer keys; templates; guidelines for reviewing templates; a complete profiling packet; guidelines for the trainer.

  2. [Retrospective analysis of influence of differential protein intake on renal prognosis for progressive chronic kidney disease].

    Science.gov (United States)

    Dai, Wendi; Yin, Daoxin; Cui, Wenying; Liu, Wenhu

    2014-01-28

    To explore retrospectively the influence of differential protein intake on renal prognosis for progressive chronic kidney disease (CKD). A total of 159 chronic kidney disease patients at stages 2, 3 and 4 were enrolled and a questionnaire survey was conducted from January 2009 to July 2012. They were followed monthly and their clinical data collected, including primary disease, blood pressure, body mass index and adverse events. Laboratory tests were performed every 3 months, including biochemical parameters, protein-energy malnutrition (PEM), diet reviews and daily protein intake (DPI). A simplified MDRD formula was employed to evaluate the level of estimated glomerular filtration rate (eGFR). According to the level of DPI, they were divided into 3 groups of very low protein diet (VLPD): DPI ≤ 0.6 g · kg(-1) · d(-1), low-protein diet (LPD): DPI >0.6-protein diet (NPD): DPI ≥ 0.8 · g · kg(-1) · d(-1). Among them, 4 cases (2.50%) progressed to uremia stage and received renal replacement therapy, 2(1.25%) experienced rapid decline in renal function, 9(5.66%) were hospitalized from cardio-cerebral diseases and the 2-year kidney survival rate was 97.5%. At the end of study, among 9 patients of PEM, 2 subjects had a serum level of albumin under 32 g/L and another 7 with a BMI 0.05). Within a certain range, differential protein intake may not significantly affect the prognosis of kidney for progressive CKD patients.

  3. Procedure for conducting a human-reliability analysis for nuclear power plants. Final report

    International Nuclear Information System (INIS)

    Bell, B.J.; Swain, A.D.

    1983-05-01

    This document describes in detail a procedure to be followed in conducting a human reliability analysis as part of a probabilistic risk assessment when such an analysis is performed according to the methods described in NUREG/CR-1278, Handbook for Human Reliability Analysis with Emphasis on Nuclear Power Plant Applications. An overview of the procedure describing the major elements of a human reliability analysis is presented along with a detailed description of each element and an example of an actual analysis. An appendix consists of some sample human reliability analysis problems for further study

  4. Planning for a program design for energy environmental analysis. Progress report

    International Nuclear Information System (INIS)

    Denton, J.C.

    The work reported in this progress report is focused on determining the proper scope of a regional assessment study program suitable for BER/ERDA. Within the tentative scope selected, a tentative set of purposes, goals, and objectives is identified for a preliminary specification of a geographical region. The initial specification of the region includes the states of Pennsylvania, New Jersey, Delaware, Maryland, and Virginia. The tentative scope of considerations for the regional assessment study program encompasses the interacting facets of environment, energy, and economic well-being of the region with the overarching goal of reconciling these facets within the decision framework of the region

  5. An analysis of the Spanish electrical utility industry. Economies of scale, technological progress and efficiency

    International Nuclear Information System (INIS)

    Arcos, Angel; De Toledo, Pablo Alvarez

    2009-01-01

    In this paper we propose a model to explain the behaviour of the Spanish electrical utility industry during the period 1987-1997, under the then existing regulatory system (Marco Legal Estable). The paper will study the presence of economies of scale, the effect of technological progress and the differences in the efficiency of the different companies within the market. The paper concludes that the Spanish electrical utility industry was not, in fact, characterized by economies of scale during this period, but witnessed a great improvement in efficiency within that period. All the critical market factors remind stable. (author)

  6. Analysis of ovine colostrum to detect antibody against progressive pneumonia virus.

    OpenAIRE

    Taylor, T B; Banowetz, G M; Schipper, I A; Gabrielson, D A

    1982-01-01

    Immunoglobulins were isolated and purified from the colostrum and serum of progressive pneumonia virus infected sheep and also from non-infected control sheep. Four classes of immunoglobulins were isolated from sheep colostrum (IgG1, IgG2, IgA and Ig10s). Three classes of immunoglobulins were isolated from sheep serum (IgG1, IgG2 and IgM). Low levels of virus neutralizing activity were demonstrated only in the whole serum and purified serum IgG1 preparations. No complement fixing activity was...

  7. Analysis of higher order optical aberrations in the SLC final focus using Lie Algebra techniques

    International Nuclear Information System (INIS)

    Walker, N.J.; Irwin, J.; Woodley, M.

    1993-04-01

    The SLC final focus system is designed to have an overall demagnification of 30:1, with a β at the interaction point (β*) of 5 mm, and an energy band pass of ∼0.4%. Strong sextupole pairs are used to cancel the large chromaticity which accrues primarily from the final triplet. Third-order aberrations limit the performance of the system, the dominating terms being U 1266 and U 3466 terms (in the notation of K. Brown). Using Lie Algebra techniques, it is possible to analytically calculate the soave of these terms in addition to understanding their origin. Analytical calculations (using Lie Algebra packages developed in the Mathematica language) are presented of the bandwidth and minimum spot size as a function of divergence at the interaction point (IP). Comparisons of the analytical results from the Lie Algebra maps and results from particle tracking (TURTLE) are also presented

  8. Forecasting Final Energy Consumption using the Centered Moving Average Method and Time Series Analysis

    Directory of Open Access Journals (Sweden)

    Janina POPEANGA

    2014-05-01

    Full Text Available The forecasting of energy consumption has become one of the major fields of research in recent years. Accurate energy demand forecasting is essential in energy system operations and planning. In this paper, we will describe a method to determine the information that is useful for a good forecasting. Further, we adopt the time series modeling approach to model final energy consumption in Romania using previous data of 2010 to 2013. This method is implemented using stored procedures, developed in Oracle PL/SQL programming language. Finally, the developed model is compared for goodness of fit to the historical data and forecasting accuracy, and results are encouraging, showing that the forecast model is in control and is working correctly.

  9. Assessment of uncertainties in risk analysis of chemical establishments. The ASSURANCE project. Final summary report

    DEFF Research Database (Denmark)

    Lauridsen, K.; Kozine, Igor; Markert, Frank

    2002-01-01

    on the ranking among the adherents of the probabilistic approach. Breaking down the modelling of both frequencyand consequence assessments into suitably small elements and conducting case studies allowed identifying root causes of uncertainty in the final risk assessments. Large differences were found in both...... the frequency assessments and in the assessment ofconsequences. The report gives a qualitative assessment of the importance to the final calculated risk of uncertainties in assumptions made, in the data and the calculation methods used. This assessment can serve as a guide to areas where, in particular......This report summarises the results obtained in the ASSURANCE project (EU contract number ENV4-CT97-0627). Seven teams have performed risk analyses for the same chemical facility, an ammonia storage. The EC's Joint Research Centre at Ispra and RisøNational Laboratory co-ordinated the exercise...

  10. Final Sampling and Analysis Plan for Background Sampling, Fort Sheridan, Illinois

    National Research Council Canada - National Science Library

    1995-01-01

    .... This Background Sampling and Analysis Plan (BSAP) is designed to address this issue through the collection of additional background samples at Fort Sheridan to support the statistical analysis and the Baseline Risk Assessment (BRA...

  11. TRANSITIONING BEYOND UNDERGRADUATE HOSPITALITY EDUCATION; A DIALOGIC ANALYSIS OF FINAL YEAR HOSPITALITY STUDENTS’ NARRATIVES OF EMPLOYABILITY

    OpenAIRE

    Hine, Catherine

    2017-01-01

    Employability has become a key consideration for graduates, and society. Increasingly the trajectory of individuals at age 18 involves the completion of an undergraduate level degree qualification. This thesis presents a sociologically grounded study into the dialogic construction of employability in final year hospitality students and recent hospitality graduates. Drawing on a nationwide sample of UK based hospitality graduates, as they transition beyond undergraduate level higher educati...

  12. Final hazard classification and auditable safety analysis for the 105-C Reactor Interim Safe Storage Project

    International Nuclear Information System (INIS)

    Rodovsky, T.J.; Larson, A.R.; Dexheimer, D.

    1996-12-01

    This document summarizes the inventories of radioactive and hazardous materials present in the 105-C Reactor Facility and the operations associated with the Interim Safe Storage Project which includes decontamination and demolition and interim safe storage of the remaining facility. This document also establishes a final hazard classification and verifies that appropriate and adequate safety functions and controls are in place to reduce or mitigate the risk associated with those operations

  13. Progress in Energy Storage Technologies: Models and Methods for Policy Analysis

    Science.gov (United States)

    Matteson, Schuyler W.

    Climate change and other sustainability challenges have led to the development of new technologies that increase energy efficiency and reduce the utilization of finite resources. To promote the adoption of technologies with social benefits, governments often enact policies that provide financial incentives at the point of purchase. In their current form, these subsidies have the potential to increase the diffusion of emerging technologies; however, accounting for technological progress can improve program success while decreasing net public investment. This research develops novel methods using experience curves for the development of more efficient subsidy policies. By providing case studies in the field of automotive energy storage technologies, this dissertation also applies the methods to show the impacts of incorporating technological progress into energy policies. Specific findings include learning-dependent tapering subsidies for electric vehicles based on the lithium-ion battery experience curve, the effects of residual learning rates in lead-acid batteries on emerging technology cost competitiveness, and a cascading diffusion assessment of plug-in hybrid electric vehicle subsidy programs. Notably, the results show that considering learning rates in policy development can save billions of dollars in public funds, while also lending insight into the decision of whether or not to subsidize a given technology.

  14. In vitro root caries progression measured by 125I absorptiometry: comparison with chemical analysis

    International Nuclear Information System (INIS)

    Almqvist, H.; Wefel, J.S.; Lagerloef, F.E.; Ekstrand, J.; Henrikson, C.O.

    1988-01-01

    Radiation from a 125 I source and a non-image-forming detector was used for non-destructive measurements of root caries progression. Blocks were cut parallel to the cementum surface of unexposed human roots. These blocks were then individually demineralized in under-saturated calcium phosphate solutions over an 84-hour period. In order for the in vitro root surface demineralization to be followed, the changes in transmission (delta T) through the blocks were measured, by 125 I absorptiometry, eight times during the course of the experiment. Chemical analyses of the calcium output (delta Ca) from the blocks into the demineralizing solutions were also performed, and the rate of demineralization (Vdem) was calculated from these values. The precision of 125 I absorptiometry was calculated from 176 duplicate transmission measurements, and the coefficient of variation was found to be 0.20%. The correlation coefficient between delta T and total delta Ca for each of 22 cementum/dentin blocks ranged between r = 0.934 and r = 0.998. The progression of root hard-tissue lesions observed by these two methods and by the calculated Vdem was found to be proportional to the square and cubic roots of time. The study shows that 125 I absorptiometry can be used for continuous non-destructive measurements of root hard-tissue demineralization in vitro

  15. Analysis of airborne radiometric data. Volume 2. Description, listing, and operating instructions for the code DELPHI/MAZAS. Final report

    International Nuclear Information System (INIS)

    Sperling, M.; Shreve, D.C.

    1978-01-01

    The computer code DELPHI is an interactive English language command system for the analysis of airborne radiometric data. The code includes modules for data reduction, data simulation, time filtering, data adjustment and graphical presentation of the results. DELPHI is implemented in FORTRAN on a DEC-10 computer. This volume gives a brief set of operations instructions, samples of the output obtained from hard copies of the display on a Tektronix terminal and finally a listing of the code

  16. Analysis of airborne radiometric data. Volume 2. Description, listing, and operating instructions for the code DELPHI/MAZAS. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sperling, M.; Shreve, D.C.

    1978-12-01

    The computer code DELPHI is an interactive English language command system for the analysis of airborne radiometric data. The code includes modules for data reduction, data simulation, time filtering, data adjustment and graphical presentation of the results. DELPHI is implemented in FORTRAN on a DEC-10 computer. This volume gives a brief set of operations instructions, samples of the output obtained from hard copies of the display on a Tektronix terminal and finally a listing of the code.

  17. Verification and Validation Process for Progressive Damage and Failure Analysis Methods in the NASA Advanced Composites Consortium

    Science.gov (United States)

    Wanthal, Steven; Schaefer, Joseph; Justusson, Brian; Hyder, Imran; Engelstad, Stephen; Rose, Cheryl

    2017-01-01

    The Advanced Composites Consortium is a US Government/Industry partnership supporting technologies to enable timeline and cost reduction in the development of certified composite aerospace structures. A key component of the consortium's approach is the development and validation of improved progressive damage and failure analysis methods for composite structures. These methods will enable increased use of simulations in design trade studies and detailed design development, and thereby enable more targeted physical test programs to validate designs. To accomplish this goal with confidence, a rigorous verification and validation process was developed. The process was used to evaluate analysis methods and associated implementation requirements to ensure calculation accuracy and to gage predictability for composite failure modes of interest. This paper introduces the verification and validation process developed by the consortium during the Phase I effort of the Advanced Composites Project. Specific structural failure modes of interest are first identified, and a subset of standard composite test articles are proposed to interrogate a progressive damage analysis method's ability to predict each failure mode of interest. Test articles are designed to capture the underlying composite material constitutive response as well as the interaction of failure modes representing typical failure patterns observed in aerospace structures.

  18. An analysis of drought in the Northern Great Plains: Summary of progress

    Energy Technology Data Exchange (ETDEWEB)

    Sieg, C.H. [Forest Service, Rapid City, SD (United States). Rocky Mountain Station; Meko, D.M.; Ni, W. [Univ. of Arizona, Tucson, AZ (United States). Lab. of Tree-Ring Research; DeGaetano, A.T.; Miller, J.R. Jr.; Bunkers, M.J. [South Dakota School of Mines and Technology, Rapid City, SD (United States)

    1995-12-31

    The purpose of this research is to increase the understanding of the magnitude, recurrence interval and periodicity of drought in the Northern Great Plains both from dendrochronological reconstructions and from analyses of available climate data. The objectives are to: (1) develop a network of climatically sensitive tree-ring chronologies to fill a void in the Northern Great Plains; (2) isolate climate variables most highly correlated with tree-growth; (3) reconstruct the drought history for the past 100 to 300 years; (4) identify regions which are climatically similar with respect to drought; (5) isolate patterns of drought persistence or recurrence; and (6) determine if drought recurrence is related to southern oscillation events. This paper summarizes progress on development of tree-ring chronologies in the Northern Great Plains preliminary analyses on the relationship between annual tree-ring widths and both precipitation and soil moisture and efforts to identify climatic regions and drought patterns in this region from climatic records.

  19. Recent Progress and Development of Crystal Structure Analysis of Enzymes and Other Proteins

    Science.gov (United States)

    Tanokura, Masaru; Nagata, Koji; Miyazono, Ken-Ichi; Miyakawa, Takuya; Okai, Masahiko

    Structural biology has made tremendous progress in this decade. Here we briefly introduce the Target Proteins Research Program, a national project promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The program aims to reveal the structure and function of proteins that are of great importance in both academic research and industrial application. We also summarize the results of structure-function analyses of (i) transcriptional regulatory proteins useful for the breading of drought and heat stress tolerant crops, (ii) useful enzymes for the production of chiral compounds, and (iii) useful enzymes for the degradation of environmental pollution substances. These results can be utilized in various areas of industries, to enhance food production, to improve the efficiency of pharmaceutical compound production, and to promote the bioremediation of contaminated soil and water.

  20. Progress on 129I analysis and its application in environmental and geological researches

    DEFF Research Database (Denmark)

    Fan, Yukun; Hou, Xiaolin; Zhou, Weijian

    2013-01-01

    the interferences, as well as preparation of suitable target for AMS measurement. The major applications in environmental and geological researches are reviewed, which mainly focus on the new progress and potential development in the future. The application of 129I in the investigation of radioactive contamination...... in environmental level. Based on its source terms, chemical properties and environmental behaviors, 129Ican be applied for geological dating in a range of 2–80Ma, investigation of formation and migration of hydrocarbon, circulation of ocean water, atmospheric process of iodine, as well as reconstruction...... of dispersion and migration of short-lived radioisotopes of iodine released from nuclear accidents. This article aims to summarize and critically compare the analytical techniques used for 129I measurement and chemical methods for separation of iodine from various sample matrices, purification from...

  1. Nuclear and radiochemical techniques in chemical analysis. Progress report, August 1, 1977--July 31, 1978

    International Nuclear Information System (INIS)

    Finston, H.L.; Williams, E.T.

    1978-07-01

    The study of neutron-absorption cross sections of reactor-produced radionuclides has been completed, and results are reported for 22 Na, 126 I, 139 Ce, 88 Y, 184 Re, 182 Ta, 54 Mn, and 94 Zr. The results for 22 Na indicate the existence of a resonance in the thermal region which could explain the discrepancies in the published values for the thermal cross section. The results of air-sampling experiments are described as is the proton-induced x-ray emission system developed at Brooklyn College. Work on sample preparation and applications of the PIXE technique are given. Progress on a nuclear method to determine fluorine-containing gaseous compounds is reported. Work on solvent extraction with propylene carbonate and experiments involving an acid-base hypothesis are described

  2. Calculation analysis of the radiation characteristics of the Ch NPP Unit 1 reactor structures after the final shutdown

    International Nuclear Information System (INIS)

    Burlakov, E.V.; Bylkin, B.K.; Garin, E.V.; Davydova, G.B.; Zverkov, Yu.A.; Krayushkin, A.V.; Neretin, Yu.A.; Nosovskij, A.V.; Sejda, V.A.; Skripov, A.E.; Tushev, D.V.

    2000-01-01

    The article deals with the ways of assessing RBMK structures radiation parameters, which can in future serve as a basis for work on the tasks related to planning and actual decommissioning of Power Units with RBMK reactors. It gives the main results of the calculation analysis of the radiation characteristics of the elements of the Ch NPP Unit 1 reactor structures at the final Unit shutdown stage. The article also gives a forecast of their changes as the time passes, up to 150 years of the reactor cooling. The article describes the methodology and the results of the analysis carried out. 8 refs., 3 tab., 4 figs

  3. Bulk hydrogen analysis, using neutrons. Final report of the second research co-ordination meeting

    International Nuclear Information System (INIS)

    1998-11-01

    The aims of the Second Co-ordination Meting (RCM) of the Coordinated Research Programme (CRP) were to report on and review progress against the work programme set at the beginning of the CRP and to discuss the work plans for the second half of the programme. In many cases hydrogen is required to be measured in a bulk medium rather than merely at a surface. For this reason neutrons are used due to their high penetrating power in dense material. In addition, the mass attenuation coefficient for neutrons in hydrogen is significantly larger than for all other elements, meaning that neutrons have a higher probability of interacting with hydrogen than with other elements in the sample matrix. Neutrons have been used in the following areas: Fast Neutron Transmission, Scattering and Activation Technique; Digital Neutron Imaging; Hydrogen Detection by Epithermal Neutrons; Microscopic Behaviour of Hydrogen in Bulk Materials

  4. Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.

    Directory of Open Access Journals (Sweden)

    Michael C Weiger

    Full Text Available Cancer cells alter their migratory properties during tumor progression to invade surrounding tissues and metastasize to distant sites. However, it remains unclear how migratory behaviors differ between tumor cells of different malignancy and whether these migratory behaviors can be utilized to assess the malignant potential of tumor cells. Here, we analyzed the migratory behaviors of cell lines representing different stages of breast cancer progression using conventional migration assays or time-lapse imaging and particle image velocimetry (PIV to capture migration dynamics. We find that the number of migrating cells in transwell assays, and the distance and speed of migration in unconstrained 2D assays, show no correlation with malignant potential. However, the directionality of cell motion during 2D migration nicely distinguishes benign and tumorigenic cell lines, with tumorigenic cell lines harboring less directed, more random motion. Furthermore, the migratory behaviors of epithelial sheets observed under basal conditions and in response to stimulation with epidermal growth factor (EGF or lysophosphatitic acid (LPA are distinct for each cell line with regard to cell speed, directionality, and spatiotemporal motion patterns. Surprisingly, treatment with LPA promotes a more cohesive, directional sheet movement in lung colony forming MCF10CA1a cells compared to basal conditions or EGF stimulation, implying that the LPA signaling pathway may alter the invasive potential of MCF10CA1a cells. Together, our findings identify cell directionality as a promising indicator for assessing the tumorigenic potential of breast cancer cell lines and show that LPA induces more cohesive motility in a subset of metastatic breast cancer cells.

  5. Nuclear waste criticality analysis. Quarterly progress report, 1 October--31 December 1995

    International Nuclear Information System (INIS)

    Culbreth, W.G.

    1996-01-01

    The work to date includes the preparation of a report related to criticality in spent fuel, a report on the Oklo reactors and their relevance to Yucca Mountain, and the creation of a computer program to model the Oklo reactors. The objective of the program includes a computational model of the only known natural analogue to an underground nuclear waste repository and the possible application of the model to predict the long-term behavior of Yucca Mountain. A final summary of all work completed will be presented after the end of the project on February 29, 1996

  6. Grid-connected ICES: preliminary feasibility analysis and evaluation. Volume 3. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-06-30

    Maps, charts, and drawings of the Demonstration Community for the grid-connected ICES project composed of the medical complex in New Orleans (HEAL) are presented in Appendix A. The physical profile of the existing buildings and site plans is included. Demand profiles for steam, electric, gas, etc. are presented in Appendix B with extensive tables and graphs. Air quality and noise pollution data are presented in Appendix C. Data on financing in Appendix D are presented and also texts and information on revenue bonds are given. The final appendix gives qualifications for personnel for HEAL; NOSPI; de Laureal Engineers, Inc.; and Orr-Schelen-Mayeron and Associates, Inc.

  7. Steam generator automated eddy current data analysis: A benchmarking study. Final report

    International Nuclear Information System (INIS)

    Brown, S.D.

    1998-12-01

    The eddy current examination of steam generator tubes is a very demanding process. Challenges include: complex signal analysis, massive amount of data to be reviewed quickly with extreme precision and accuracy, shortages of data analysts during peak periods, and the desire to reduce examination costs. One method to address these challenges is by incorporating automation into the data analysis process. Specific advantages, which automated data analysis has the potential to provide, include the ability to analyze data more quickly, consistently and accurately than can be performed manually. Also, automated data analysis can potentially perform the data analysis function with significantly smaller levels of analyst staffing. Despite the clear advantages that an automated data analysis system has the potential to provide, no automated system has been produced and qualified that can perform all of the functions that utility engineers demand. This report investigates the current status of automated data analysis, both at the commercial and developmental level. A summary of the various commercial and developmental data analysis systems is provided which includes the signal processing methodologies used and, where available, the performance data obtained for each system. Also, included in this report is input from seventeen research organizations regarding the actions required and obstacles to be overcome in order to bring automatic data analysis from the laboratory into the field environment. In order to provide assistance with ongoing and future research efforts in the automated data analysis arena, the most promising approaches to signal processing are described in this report. These approaches include: wavelet applications, pattern recognition, template matching, expert systems, artificial neural networks, fuzzy logic, case based reasoning and genetic algorithms. Utility engineers and NDE researchers can use this information to assist in developing automated data

  8. Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: a meta-analysis

    DEFF Research Database (Denmark)

    Walsh, Michael; Catapano, Fausta; Szpirt, Wladimir

    2011-01-01

    Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis.......Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis....

  9. Experimental investigations and seismic analysis for benchmark study of 1000 MW WWER type units (water-cooled and moderated reactor) nuclear power plant Kozloduy. Final report from 1 November 1994 - 31 October 1995

    International Nuclear Information System (INIS)

    Sachanski, S.

    1996-01-01

    This final report summarizes the research carried out and the results obtained presented in previous progress reports. In includes the description of the research carried out, namely, definition of terms and references, criteria, design parameters and methods of analysis; development of 3-dimensional and 2-dimensional mathematical models for diesel generator stations concerning seismic analyses; supports and anchorages analyses and seismic capacity estimation for main components of the cooling system; methodology for verification of component anchorages; conclusions drawn concerning the seismic safety of Kozloduy NPP

  10. Impact of OSHA final rule--recording hearing loss: an analysis of an industrial audiometric dataset.

    Science.gov (United States)

    Rabinowitz, Peter M; Slade, Martin; Dixon-Ernst, Christine; Sircar, Kanta; Cullen, Mark

    2003-12-01

    The 2003 Occupational Safety and Health Administration (OSHA) Occupational Injury and Illness Recording and Reporting Final Rule changed the definition of recordable work-related hearing loss. We performed a study of the Alcoa Inc. audiometric database to evaluate the impact of this new rule. The 2003 rule increased the rate of potentially recordable hearing loss events from 0.2% to 1.6% per year. A total of 68.6% of potentially recordable cases had American Academy of Audiology/American Medical Association (AAO/AMA) hearing impairment at the time of recordability. On average, recordable loss occurred after onset of impairment, whereas the non-age-corrected 10-dB standard threshold shift (STS) usually preceded impairment. The OSHA Final Rule will significantly increase recordable cases of occupational hearing loss. The new case definition is usually accompanied by AAO/AMA hearing impairment. Other, more sensitive metrics should therefore be used for early detection and prevention of hearing loss.

  11. Analysis of factors affecting the final body weight in selected rabbit breeds

    Directory of Open Access Journals (Sweden)

    Jacek Zawiślak

    2015-06-01

    Full Text Available The objective of this research was to determine the effect of breed, feed type and sex, on the final body weight in New Zealand white and Blanc de Termonde rabbits. The experiment was conducted on a farm in the Małopolska Province in the south of Poland. Rabbits of both breeds were kept in identical conditions up to the age of 90 days. However, they were fed using two different methods – with commercial balanced (granulated feed (9.75 MJ, 155 g protein and farm-made feed (9.54 MJ, 157 g protein. Among New Zealand White rabbits, commercial balanced feed was given to 38 males and 42 females, whereas farm-made feed to 37 males and 38 females. Among Blanc de Termonde rabbits, commercial balanced feed was given to 65 males and 68 females, and farm-made feed to 54 males and 60 females. Daily gains were determined for both examined breeds divided into sexes. Then, we calculated interactions between breed and feed type, between breed and sex, as well as between feed type and sex. The mean body weights on the 90th day of fattening differed for both sexes and feed types. For both rabbit breeds, the higher mean final body weight was observed in case of feeding with the commercial balanced feed, whereas the highest body weight (2515.13 g was registered for the females of Blanc de Termonde rabbits.

  12. Impact of OSHA Final Rule—Recording Hearing Loss: An Analysis of an Industrial Audiometric Dataset

    Science.gov (United States)

    Rabinowitz, Peter M.; Slade, Martin; Dixon-Ernst, Christine; Sircar, Kanta; Cullen, Mark

    2013-01-01

    The 2003 Occupational Safety and Health Administration (OSHA) Occupational Injury and Illness Recording and Reporting Final Rule changed the definition of recordable work-related hearing loss. We performed a study of the Alcoa Inc. audiometric database to evaluate the impact of this new rule. The 2003 rule increased the rate of potentially recordable hearing loss events from 0.2% to 1.6% per year. A total of 68.6% of potentially recordable cases had American Academy of Audiology/American Medical Association (AAO/AMA) hearing impairment at the time of recordability. On average, recordable loss occurred after onset of impairment, whereas the non-age-corrected 10-dB standard threshold shift (STS) usually preceded impairment. The OSHA Final Rule will significantly increase recordable cases of occupational hearing loss. The new case definition is usually accompanied by AAO/AMA hearing impairment. Other, more sensitive metrics should therefore be used for early detection and prevention of hearing loss. PMID:14665813

  13. ESG-CET Final Progress Title

    Energy Technology Data Exchange (ETDEWEB)

    Don Middleton

    2011-10-06

    Drawing to a close after five years of funding from DOE's ASCR and BER program offices, the SciDAC-2 project called the Earth System Grid (ESG) Center for Enabling Technologies has successfully established a new capability for serving data from distributed centers. The system enables users to access, analyze, and visualize data using a globally federated collection of networks, computers and software. The ESG software - now known as the Earth System Grid Federation (ESGF) - has attracted a broad developer base and has been widely adopted so that it is now being utilized in serving the most comprehensive multi-model climate data sets in the world. The system is used to support international climate model intercomparison activities as well as high profile U.S. DOE, NOAA, NASA, and NSF projects. It currently provides more than 25,000 users access to more than half a petabyte of climate data (from models and from observations) and has enabled over a 1,000 scientific publications.

  14. Chemical Reactions at Surfaces. Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Freud, Hans-Joachim [Max-Planck-Gesellschaft, Berlin (Germany). Fritz-Haber-Inst.

    2003-02-21

    The Gordon Research Conference (GRC) on Chemical Reactions at Surfaces was held at Holiday Inn, Ventura, California, 2/16-21/03. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

  15. Innovative conservation housing. Final progress report

    Energy Technology Data Exchange (ETDEWEB)

    Nuttle, D.A.

    1983-01-01

    A new passive solar thermal storage brick was developed and tested. A new insulating curtain concept was developed to assist in passive solar heating and cooling. A steel truss was designed to replace the wood truss in solar attic applications where the wood truss typically suffers some 50% loss of structural strength. Improvements were made of the dry composting toilet and grey water recycling for homes. An algae cultivation system was created for production of food, feed, fertilizer, or biomass as needed for home, farm, or industry. New concepts were explored in the areas of economy shelter, solar hot water heating, home generation of electricity, edible landscapes and other home food production, growing of fiber crops for cottage industry, storage, insulation, solar cooking, and solar refrigeration. (LEW)

  16. Electron Donor Acceptor Interactions. Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Ana L. [Arizona State Univ., Tempe, AZ (United States)

    2002-08-16

    The Gordon Research Conference (GRC) on Electron Donor Acceptor Interactions was held at Salve Regina University, Newport, Rhode Island, 8/11-16/02. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

  17. Preliminary analysis of the transient overpower accident for CRBRP. Final report

    International Nuclear Information System (INIS)

    Kastenberg, W.E.; Frank, M.V.

    1975-07-01

    A preliminary analysis of the transient overpower accident for the Clinch River Breeder Reactor Plant (CRBRP) is presented. Several uncertainties in the analysis and the estimation of ramp rates during the transition to disassembly are discussed. The major conclusions are summarized

  18. Use of functionalized surfactants in flame atomic analysis: Final technical report

    International Nuclear Information System (INIS)

    Armstrong, D.W.

    1987-01-01

    Research results in the following areas are briefly summarized: basic properties of surfactants, micelles, and cyclodextrins as they relate to chemical analysis; use of functionalized surfactants, micelles, and cyclodextrins in spectroscopic analysis; macromolecular separation theory and mechanism; use of functionalized surfactants and cyclodextrins in separations; capillary work for future coupling of spectroscopic and LC projects

  19. National Research Council Dialogue to Assess Progress on NASA's Systems Engineering Cost/Risk Analysis Capability Roadmap Development: General Background and Introduction

    Science.gov (United States)

    Regenie, Victoria

    2005-01-01

    Contents include the following: General Background and Introduction of Capability. Roadmaps for Systems Engineering Cost/Risk Analysis. Agency Objectives. Strategic Planning Transformation. Review Capability Roadmaps and Schedule. Review Purpose of NRC Review. Capability Roadmap Development (Progress to Date).

  20. A Small Disc Area Is a Risk Factor for Visual Field Loss Progression in Primary Open-Angle Glaucoma: The Glaucoma Stereo Analysis Study

    Directory of Open Access Journals (Sweden)

    Yasushi Kitaoka

    2018-01-01

    Full Text Available Purpose. The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX to assess various morphological parameters of the optic nerve head (ONH in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods. The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD slope values of all patients into the progression group (<−0.3 dB/year and no-progression group (≧−0.3 dB/year. ONH morphological parameters were calculated with prototype analysis software. The correlations between glaucomatous visual field progression and patient characteristics or each ONH parameter were analyzed with Spearman’s rank correlation coefficient. Results. The MD slope averages in the progression group and no-progression group were −0.58 ± 0.28 dB/year and 0.05 ± 0.26 dB/year, respectively. Among disc parameters, vertical disc width (diameter, disc area, cup area, and cup volume in the progression group were significantly less than those in the no-progression group. Logistic regression analysis revealed a significant association between the visual field progression and disc area (odds ratio 0.49/mm2 disc area. Conclusion. A smaller disc area may be associated with more rapid glaucomatous visual field progression.

  1. Final Report for Geometric Analysis for Data Reduction and Structure Discovery DE-FG02-10ER25983, STRIPES award # DE-SC0004096

    Energy Technology Data Exchange (ETDEWEB)

    Vixie, Kevin R. [Washington State Univ., Pullman, WA (United States)

    2014-11-27

    This is the final report for the project "Geometric Analysis for Data Reduction and Structure Discovery" in which insights and tools from geometric analysis were developed and exploited for their potential to large scale data challenges.

  2. Everolimus in advanced, progressive, well-differentiated, non-functional neuroendocrine tumors: RADIANT-4 lung subgroup analysis.

    Science.gov (United States)

    Fazio, Nicola; Buzzoni, Roberto; Delle Fave, Gianfranco; Tesselaar, Margot E; Wolin, Edward; Van Cutsem, Eric; Tomassetti, Paola; Strosberg, Jonathan; Voi, Maurizio; Bubuteishvili-Pacaud, Lida; Ridolfi, Antonia; Herbst, Fabian; Tomasek, Jiri; Singh, Simron; Pavel, Marianne; Kulke, Matthew H; Valle, Juan W; Yao, James C

    2018-01-01

    In the phase III RADIANT-4 study, everolimus improved median progression-free survival (PFS) by 7.1 months in patients with advanced, progressive, well-differentiated (grade 1 or grade 2), non-functional lung or gastrointestinal neuroendocrine tumors (NETs) vs placebo (hazard ratio, 0.48; 95% confidence interval [CI], 0.35-0.67; P < .00001). This exploratory analysis reports the outcomes of the subgroup of patients with lung NETs. In RADIANT-4, patients were randomized (2:1) to everolimus 10 mg/d or placebo, both with best supportive care. This is a post hoc analysis of the lung subgroup with PFS, by central radiology review, as the primary endpoint; secondary endpoints included objective response rate and safety measures. Ninety of the 302 patients enrolled in the study had primary lung NET (everolimus, n = 63; placebo, n = 27). Median PFS (95% CI) by central review was 9.2 (6.8-10.9) months in the everolimus arm vs 3.6 (1.9-5.1) months in the placebo arm (hazard ratio, 0.50; 95% CI, 0.28-0.88). More patients who received everolimus (58%) experienced tumor shrinkage compared with placebo (13%). Most frequently reported (≥5% incidence) grade 3-4 drug-related adverse events (everolimus vs. placebo) included stomatitis (11% vs. 0%), hyperglycemia (10% vs. 0%), and any infections (8% vs. 0%). In patients with advanced, progressive, well-differentiated, non-functional lung NET, treatment with everolimus was associated with a median PFS improvement of 5.6 months, with a safety profile similar to that of the overall RADIANT-4 cohort. These results support the use of everolimus in patients with advanced, non-functional lung NET. The trial is registered with ClinicalTrials.gov (no. NCT01524783). © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

  3. Analysis of Fat Intake Based on the U.S. Department of Agriculture's 1994-96, 1998 Continuing Survey of Food Intakes by Individuals (CSFII, Final Report)

    Science.gov (United States)

    EPA released the final report, Analysis of Fat Intake Based on USDA’s 1994-1996, 1998 Continuing Survey of Food Intakes by Individuals (CSFII, Final Report). For this report, the EPA conducted an analysis of fat consumption across the U.S. population based on data derived...

  4. Transportation Routing Analysis Geographic Information System -- TRAGIS, progress on improving a routing tool

    International Nuclear Information System (INIS)

    Johnson, P.E.; Lester, P.B.

    1998-05-01

    The Transportation Routing Analysis Geographic Information System (TRAGIS) model provides a useful tool to calculate and analyze transportation routes for radioactive materials within the continental US. This paper outlines some of the features available in this model

  5. Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression.

    Science.gov (United States)

    Flisikowska, Tatiana; Stachowiak, Monika; Xu, Hongen; Wagner, Alexandra; Hernandez-Caceres, Alejandra; Wurmser, Christine; Perleberg, Carolin; Pausch, Hubert; Perkowska, Anna; Fischer, Konrad; Frishman, Dmitrij; Fries, Ruedi; Switonski, Marek; Kind, Alexander; Saur, Dieter; Schnieke, Angelika; Flisikowski, Krzysztof

    2017-07-26

    We compared gene expression in low and high-grade intraepithelial dysplastic polyps from pigs carrying an APC 1311 truncating mutation orthologous to human APC 1309 , analysing whole samples and microdissected dysplastic epithelium. Gene set enrichment analysis revealed differential expression of gene sets similar to human normal mucosa versus T1 stage polyps. Transcriptome analysis of whole samples revealed many differentially-expressed genes reflecting immune infiltration. Analysis of microdissected dysplastic epithelium was markedly different and showed increased expression in high-grade intraepithelial neoplasia of several genes known to be involved in human CRC; and revealed possible new roles for GBP6 and PLXND1. The pig model thus facilitates analysis of CRC pathogenesis.

  6. Extensive Analysis of Elastase-Induced Pulmonary Emphysema in Rats: ALP in the Lung, a New Biomarker for Disease Progression?

    Science.gov (United States)

    Inoue, Ken-ichiro; Koike, Eiko; Yanagisawa, Rie; Takano, Hirohisa

    2010-01-01

    It is accepted that pulmonary exposure of rodents to porcine pancreatic elastase (ELT) induces lesions that morphologically resemble human emphysema. Nonetheless, extensive analysis of this model has rarely been conducted. The present study was designed to extensively examine the effects of ELT on lung inflammation, cell damage, emphysematous change, and cholinergic reactivity in rats. Intratracheal administration of two doses of ELT induced 1) a proinflammatory response in the lung that was characterized by significant infiltration of macrophages and an increased level of interleukin-1β in lung homogenates, 2) lung cell damage as indicated by higher levels of total protein, lactate dehydrogenase, and alkaline phosphatase (ALP) in lung homogenates, 3) emphysema-related morphological changes including airspace enlargement and progressive destruction of alveolar wall structures, and 4) airway responsiveness to methacholine including an augmented Rn value. In addition, ELT at a high dose was more effective than that at a low dose. This is the novel study to extensively analyze ELT-induced lung emphysema, and the analysis might be applied to future investigations that evaluate new therapeutic agents or risk factors for pulmonary emphysema. In particular, ALP in lung homogenates might be a new biomarker for the disease progression/exacerbation. PMID:20216950

  7. Consumer demand analysis: solar heating and cooling of buildings. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Scott, J.E.

    1976-09-01

    This study concerns the acceptability of solar heating and cooling to homebuyers for residential applications. The study assesses the extent of homeowner awareness of solar technologies, estimates the acceptability of elevated first costs including willingness to trade higher initial costs for life cycle savings, and investigates the impact of solar aesthetics. Also explored are other areas of potential concern to homeowners in evaluating a solar alternative as well as positive motivations that would encourage purchase. Finally, the socioeconomic and attitudinal characteristics of individuals more likely to purchase a solar home rather than a conventional home were studied. The results are based on group depth interviews and personal interviews with active homeseekers, top executives of large residential development firms, and architects. The sample was split evenly between Denver, Colorado and the Philadelphia, Pa./Wilmington, Del. areas. Implications of the results for the commercialization of solar energy and possible public policy decisions are also discussed.

  8. Trend analysis report on energy consumptions and savings in France in 2012 and 2013: final report

    International Nuclear Information System (INIS)

    Pollier, Karine; Gregory, Chedin

    2014-09-01

    This report presents and comments a large set of data regarding CO 2 and energy savings recorded in France since 1990 with a focus on the 2008-2012 period which has been marked by a financial and economic crisis which had a strong impact on energy demand. In its first part, the report presents the French economic and energetic context since 1990 with a focus on years between 2008 and 2013. It is based on the last available energy assessments published by the French Ministry of Ecology, Sustainable Development and Energy and addresses the following issues: a fragile economic context, relatively high energy prices, a decrease of final energy consumption since 2010, and a reduction of industry energy intensity. The second part addresses CO 2 and energy savings generated by France between 1990 and 2012, with a focus on recent years: overview of the evolutions in the industrial sector, in the transport sector, and in the building sector (existing buildings)

  9. IVHS Institutional Issues and Case Studies, Analysis and Lessons Learned, Final Report

    Science.gov (United States)

    1994-04-01

    This 'Analysis and Lessons Learned' report contains observations, conclusions, and recommendations based on the performance of six case studies of Intelligent Vehicle-Highway Systems (IVHS) projects. Information to support the development of the case...

  10. APPLICATION OF AEM IN PROGRESSIVE COLLAPSE DYNAMICS ANALYSIS OF R.C. STRUCTURES

    OpenAIRE

    Osama El-Mahdy; El-Sayed El-Kasaby; Hala Abusafa; Amr El-Gamal

    2018-01-01

    The Finite Element Method (FEM) and the other numerical strategies are viably actualized in linear and non-linear analysis of structures. Recently, a new displacement based on Applied Element Method (AEM) has been developed. It is applicable for static and dynamic for both linear and non-linear analysis of framed and continuum structures. In AEM, the structural member is partitioned into virtual elements connected through normal and shear springs representing stresses and strains of certain p...

  11. READY I system for the UNIVAC 1108 agricultural analysis programs. Final report

    International Nuclear Information System (INIS)

    1978-02-01

    Two programs in the Ready I system are specifically designed for agricultural analysis, the Crops Model and the Livestock IV Program. The Crops Model is used to determine the survivability of selected agricultural crops against a particular nuclear attack and to display the results in edited form. The Livestock IV Program computers livestock and poultry mortalities for time periods of 30 and 60 days after a nuclear attack and produces an edited analysis of the results

  12. Next Generation Electromagnetic Pump Analysis Tools (PLM DOC-0005-2188). Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Stregy, Seth [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Dasilva, Ana [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Yilmaz, Serkan [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Saha, Pradip [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States); Loewen, Eric [GE Hitachi Nuclear Energy Americas LLC, Wilmington, NC (United States)

    2015-10-29

    This report provides the broad historical review of EM Pump development and details of MATRIX development under this project. This report summarizes the efforts made to modernize the legacy performance models used in previous EM Pump designs and the improvements made to the analysis tools. This report provides information on Tasks 1, 3, and 4 of the entire project. The research for Task 4 builds upon Task 1: Update EM Pump Databank and Task 3: Modernize the Existing EM Pump Analysis Model, which are summarized within this report. Where research for Task 2: Insulation Materials Development and Evaluation identified parameters applicable to the analysis model with Task 4, the analysis code was updated, and analyses were made for additional materials. The important design variables for the manufacture and operation of an EM Pump that the model improvement can evaluate are: space constraints; voltage capability of insulation system; maximum flux density through iron; flow rate and outlet pressure; efficiency and manufacturability. The development of the next-generation EM Pump analysis tools during this two-year program provides information in three broad areas: Status of analysis model development; Improvements made to older simulations; and Comparison to experimental data.

  13. Production and analysis of thermonuclear plasmas in high beta devices. Progress report

    International Nuclear Information System (INIS)

    1976-01-01

    During the October 1975--July 1976 reporting period, significant progress was reported in all ongoing projects funded by ERDA. Construction of the major new experiment THOR was delayed due to difficulties in bringing the Maxwell Laboratory swinging LC-pulse generators up to specifications. These technical difficulties have now been overcome and the pulsers were accepted late in April. THOR is almost back on schedule and physics results on plasma heating are expected by September of this year. TERP, originally funded as an Exploratory Concept, has been operating successfully for over a year and given confinement physics results which are important for the development of Maximum Beta Tokamaks. The Measurement and Instrumentation efforts have resulted in a number of instrument developments that have been successfully tested on FTP or STP, our fast or small theta pinches. Both FTP and STP were studied intensively to obtain ion and electron heating rates and anomalous post-implosion resistivities. These results are supported by the University of Maryland theory and simulation programs and SAI

  14. Tumor progression: analysis of the instability of the metastatic phenotype, sensitivity to radiation and chemotherapy

    International Nuclear Information System (INIS)

    Welch, D.R.

    1984-01-01

    The major complications for tumor therapy are 1) tumor spread (metastasis); 2) the mixed nature of tumors (heterogeneity); and 3) the capacity of tumors to evolve (progress). To study these tumor characteristics, the rat 13762NF mammary adenocarcinoma was cloned and studied for metastatic properties and sensitivities to therapy (chemotherapy, radiation and hyperthermia). The cell clones were heterogeneous and no correlation between metastatic potential and therapeutic sensitivities was observed. Further, these phenotypes were unstable during pasage in vitro; yet, the changes were clone dependent and reproducible using different cryoprotected cell stocks. To understand the phenotypic instability, subclones were isolated from low and high passage cell clones. The results demonstrated that 1) tumor cells are heterogeneous for multiple phenotypes; 2) tumor cells are unstable for multiple phenotypes; 3) the magnitude, direction and time of occurrence of phenotypic drift is clone dependent; 4) the sensitivity of cell clones to ionizing radiation (γ or heat) and chemotherapy agents is independent of their metastatic potential; 5) shifts in metastatic potential and sensitivity to therapy may occur simultaneously but are not linked; and 6) tumor cells independently diverge to form several subpopulations with unique phenotypic profiles

  15. Analysis of progression of fatigue conditions in biceps brachii muscles using surface electromyography signals and complexity based features.

    Science.gov (United States)

    Karthick, P A; Makaram, Navaneethakrishna; Ramakrishnan, S

    2014-01-01

    Muscle fatigue is a neuromuscular condition where muscle performance decreases due to sustained or intense contraction. It is experienced by both normal and abnormal subjects. In this work, an attempt has been made to analyze the progression of muscle fatigue in biceps brachii muscles using surface electromyography (sEMG) signals. The sEMG signals are recorded from fifty healthy volunteers during dynamic contractions under well defined protocol. The acquired signals are preprocessed and segmented in to six equal parts for further analysis. The features, such as activity, mobility, complexity, sample entropy and spectral entropy are extracted from all six zones. The results are found showing that the extracted features except complexity feature have significant variations in differentiating non-fatigue and fatigue zone respectively. Thus, it appears that, these features are useful in automated analysis of various neuromuscular activities in normal and pathological conditions.

  16. Linear and nonlinear dynamic analysis by boundary element method. Ph.D. Thesis, 1986 Final Report

    Science.gov (United States)

    Ahmad, Shahid

    1991-01-01

    An advanced implementation of the direct boundary element method (BEM) applicable to free-vibration, periodic (steady-state) vibration and linear and nonlinear transient dynamic problems involving two and three-dimensional isotropic solids of arbitrary shape is presented. Interior, exterior, and half-space problems can all be solved by the present formulation. For the free-vibration analysis, a new real variable BEM formulation is presented which solves the free-vibration problem in the form of algebraic equations (formed from the static kernels) and needs only surface discretization. In the area of time-domain transient analysis, the BEM is well suited because it gives an implicit formulation. Although the integral formulations are elegant, because of the complexity of the formulation it has never been implemented in exact form. In the present work, linear and nonlinear time domain transient analysis for three-dimensional solids has been implemented in a general and complete manner. The formulation and implementation of the nonlinear, transient, dynamic analysis presented here is the first ever in the field of boundary element analysis. Almost all the existing formulation of BEM in dynamics use the constant variation of the variables in space and time which is very unrealistic for engineering problems and, in some cases, it leads to unacceptably inaccurate results. In the present work, linear and quadratic isoparametric boundary elements are used for discretization of geometry and functional variations in space. In addition, higher order variations in time are used. These methods of analysis are applicable to piecewise-homogeneous materials, such that not only problems of the layered media and the soil-structure interaction can be analyzed but also a large problem can be solved by the usual sub-structuring technique. The analyses have been incorporated in a versatile, general-purpose computer program. Some numerical problems are solved and, through comparisons

  17. Progress report on neutron activation analysis at Dalat Nuclear Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Tuan, Nguyen Ngoc [Nuclear Research Institute, Dalat (Viet Nam)

    2003-03-01

    Neutron Activation Analysis (NAA) is one of most powerful techniques for the simultaneous multi-elements analysis. This technique has been studied and applied to analyze major, minor and trace elements in Geological, Biological and Environmental samples at Dalat Nuclear Research Reactor. At the sixth Workshop, February 8-11, 1999, Yojakarta, Indonesia we had a report on Current Status of Neutron Activation Analysis using Dalat Nuclear Research Reactor. Another report on Neutron Activation Analysis at the Dalat Nuclear Research Reactor also was presented at the seventh Workshop in Taejon, Korea from November 20-24, 2000. So in this report, we would like to present the results obtained of the application of NAA at NRI for one year as follows: (1) Determination of the concentrations of noble, rare earth, uranium, thorium and other elements in Geological samples according to requirement of clients particularly the geologists, who want to find out the mineral resources. (2) The analysis of concentration of radionuclides and nutrient elements in foodstuffs to attend the program on Asian Reference Man. (3) The evaluation of the contents of trace elements in crude oil and basement rock samples to determine original source of the oil. (4) Determination of the elemental composition of airborne particle in the Ho Chi Minh City for studying air pollution. The analytical data of standard reference material, toxic elements and natural radionuclides in seawater are also presented. (author)

  18. Progress report on neutron activation analysis at Dalat Nuclear Research Reactor

    International Nuclear Information System (INIS)

    Tuan, Nguyen Ngoc

    2003-01-01

    Neutron Activation Analysis (NAA) is one of most powerful techniques for the simultaneous multi-elements analysis. This technique has been studied and applied to analyze major, minor and trace elements in Geological, Biological and Environmental samples at Dalat Nuclear Research Reactor. At the sixth Workshop, February 8-11, 1999, Yojakarta, Indonesia we had a report on Current Status of Neutron Activation Analysis using Dalat Nuclear Research Reactor. Another report on Neutron Activation Analysis at the Dalat Nuclear Research Reactor also was presented at the seventh Workshop in Taejon, Korea from November 20-24, 2000. So in this report, we would like to present the results obtained of the application of NAA at NRI for one year as follows: (1) Determination of the concentrations of noble, rare earth, uranium, thorium and other elements in Geological samples according to requirement of clients particularly the geologists, who want to find out the mineral resources. (2) The analysis of concentration of radionuclides and nutrient elements in foodstuffs to attend the program on Asian Reference Man. (3) The evaluation of the contents of trace elements in crude oil and basement rock samples to determine original source of the oil. (4) Determination of the elemental composition of airborne particle in the Ho Chi Minh City for studying air pollution. The analytical data of standard reference material, toxic elements and natural radionuclides in seawater are also presented. (author)

  19. Deterministic sensitivity analysis of two-phase flow systems: forward and adjoint methods. Final report

    International Nuclear Information System (INIS)

    Cacuci, D.G.

    1984-07-01

    This report presents a self-contained mathematical formalism for deterministic sensitivity analysis of two-phase flow systems, a detailed application to sensitivity analysis of the homogeneous equilibrium model of two-phase flow, and a representative application to sensitivity analysis of a model (simulating pump-trip-type accidents in BWRs) where a transition between single phase and two phase occurs. The rigor and generality of this sensitivity analysis formalism stem from the use of Gateaux (G-) differentials. This report highlights the major aspects of deterministic (forward and adjoint) sensitivity analysis, including derivation of the forward sensitivity equations, derivation of sensitivity expressions in terms of adjoint functions, explicit construction of the adjoint system satisfied by these adjoint functions, determination of the characteristics of this adjoint system, and demonstration that these characteristics are the same as those of the original quasilinear two-phase flow equations. This proves that whenever the original two-phase flow problem is solvable, the adjoint system is also solvable and, in principle, the same numerical methods can be used to solve both the original and adjoint equations

  20. Powerplant productivity improvement study: policy analysis and incentive assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-05-01

    Policy options that the Illinois Commerce Commission might adopt in order to promote improved power plant productivity for existing units in Illinois are identified and analyzed. These policy options would generally involve either removing existing disincentives and/or adding direct incentives through the regulatory process. The following activities are reported: in-depth review of existing theoretical and empirical literature in the areas of power plant reliability, regulatory utility efficiency and performance incentives, and impacts of various regulatory mechanisms such as the Fuel Adjustment Clauses on productivity; contacts with other state public utility commissions known to be investigating or implementing productivity improvement incentive mechanisms; documentation and analysis of incentive mechanisms adopted or under consideration in other states; analysis of current regulatory practice in Illinois as it relates to power plant productivity incentives and disincentives; identification of candidate incentive mechanisms for consideration by the Illinois Commerce Commission; and analysis and evaluation of these candidates. 72 references, 8 figures.

  1. Progress Toward Universal Health Coverage: A Comparative Analysis in 5 South Asian Countries.

    Science.gov (United States)

    Rahman, Md Mizanur; Karan, Anup; Rahman, Md Shafiur; Parsons, Alexander; Abe, Sarah Krull; Bilano, Ver; Awan, Rabia; Gilmour, Stuart; Shibuya, Kenji

    2017-09-01

    Achieving universal health coverage is one of the key targets in the newly adopted Sustainable Development Goals of the United Nations. To investigate progress toward universal health coverage in 5 South Asian countries and assess inequalities in health services and financial risk protection indicators. In a population-based study, nationally representative household (335 373 households) survey data from Afghanistan (2014 and 2015), Bangladesh (2010 and 2014), India (2012 and 2014), Nepal (2014 and 2015), and Pakistan (2014) were used to calculate relative indices of health coverage, financial risk protection, and inequality in coverage among wealth quintiles. The study was conducted from June 2012 to February 2016. Three dimensions of universal health coverage were assessed: access to basic services, financial risk protection, and equity. Composite and indicator-specific coverage rates, stratified by wealth quintiles, were then estimated. Slope and relative index of inequality were used to assess inequalities in service and financial indicators. Access to basic care varied substantially across all South Asian countries, with mean rates of overall prevention coverage and treatment coverage of 53.0% (95% CI, 42.2%-63.6%) and 51.2% (95% CI, 45.2%-57.1%) in Afghanistan, 76.5% (95% CI, 61.0%-89.0%) and 44.8% (95% CI, 37.1%-52.5%) in Bangladesh, 74.2% (95% CI, 57.0%-88.1%) and 83.5% (95% CI, 54.4%-99.1%) in India, 76.8% (95% CI, 66.5%-85.7%) and 57.8% (95% CI, 50.1%-65.4%) in Nepal, and 69.8% (95% CI, 58.3%-80.2%) and 50.4% (95% CI, 37.1%-63.6%) in Pakistan. Financial risk protection was generally low, with 15.3% (95% CI, 14.7%-16.0%) of respondents in Afghanistan, 15.8% (95% CI, 14.9%-16.8%) in Bangladesh, 17.9% (95% CI, 17.7%-18.2%) in India, 11.8% (95% CI, 11.8%-11.9%) in Nepal, and 4.4% (95% CI, 4.0%-4.9%) in Pakistan reporting incurred catastrophic payments due to health care costs. Access to at least 4 antenatal care visits, institutional delivery, and presence

  2. Analysis of the value of post-radiation prostate biopsy in predicting subsequent disease progression

    International Nuclear Information System (INIS)

    Benda, R.; Shamsa, F.; Meetze, K.; Bolton, S.; Littrup, P.; Grignon, D.; Washington, T.; Forman, J.D.

    1997-01-01

    Purpose: To analyze the value of Transrectal ultrasound(TRUS), Color flow doppler(CFD) and Prostate specific antigen(PSA) in identifying residual disease in the prostate status post external beam radiation therapy and to determine the value of this pathologic information in predicting subsequent disease progression. Materials and Methods: As part of four prospective protocols, 146 patients had scheduled TRUS guided prostate biopsies 6-25 months status post radiation therapy. The stage distribution was: 13% T1, 51% T2, and 36% T3/T4. Fifty six percent had neo-adjuvant hormones. Conformal photon or mixed neutron/photon irradiation was given to a median 2 Gy/fraction equivalent dose of 77 Gy(range 74 to 84 Gy). Following treatment, patients were assessed by digital rectal exam (DRE), PSA and TRUS guided biopsies at 6, 12 and/or 18 months. The ultrasound and CFD results were scored as normal, suspicious or abnormal. Sextant biopsies were obtained as well as ultrasound guided biopsies from any abnormal ultrasound or doppler area. The biopsies, all read by one pathologist (DG), were graded as negative, marked, moderate, minimal therapeutic effect or positive. The median followup post radiation therapy was 33.6 months and post biopsy was 25.3 months. Comparisons were done by Kappa index with corresponding 95% CI, chi square and Fisher's exact tests. Results: Twenty-eight patients had biopsies at both six and 12-18 months. Overall 35% of patients had all negative cores, 30% had at least one core showing a marked therapeutic effect, and 35% had at least one core showing moderate or minimal therapeutic effect or were positive. Although CFD correlated with a positive biopsy in 9% and a suspicious doppler identified cancer in 15% of cases, an abnormal TRUS identified cancer in 29.5% biopsies ((49(166))). However, a serum PSA >1.5ng/ml at the time of biopsy predicted 61% of positive biopsies ((23(38))). A negative biopsy was associated with low stage (≤T2c, p=0.001), low pre

  3. Coal to SNG: Technical progress, modeling and system optimization through exergy analysis

    International Nuclear Information System (INIS)

    Li, Sheng; Ji, Xiaozhou; Zhang, Xiaosong; Gao, Lin; Jin, Hongguang

    2014-01-01

    Highlights: • Technical progresses of coal to SNG technologies are reported. • The entire coal to SNG system is modeled. • Coupling between SNG production and power generation is investigated. • Breakthrough points for further energy saving are determined. • System performance is optimized based on the first and second laws of thermodynamics. - Abstract: For both energy security and CO 2 emission reduction, synthetic natural gas (SNG) production from coal is an important path to implement clean coal technologies in China. In this paper, an overview of the progress of coal to SNG technologies, including the development of catalysts, reactor designs, synthesis processes, and systems integration, is provided. The coal to SNG system is modeled, the coupling between SNG production and power generation is investigated, the breakthrough points for further energy savings are determined, and the system performance is optimized based on the first and the second laws of thermodynamics. From the viewpoint of the first law of thermodynamics, the energy conversion efficiency of coal to SNG system can reach 59.8%. To reduce the plant auxiliary power, the breakthrough points are the development of low-energy-consumption oxygen production technology and gas purification technology or seeking new oxidants for coal gasification instead of oxygen. From the viewpoint of the second law of thermodynamics, the major exergy destruction in a coal to SNG system occurs in the coal gasification unit, SNG synthesis unit and the raw syngas cooling process. How to reduce the exergy destruction in these units is the key to energy savings and system performance enhancement. The conversion ratio of the first SNG synthesis reactor and the split ratio of the recycle gas are key factors that determine the performance of both the SNG synthesis process and the whole plant. A “turning point” phenomenon is observed: when the split ratio is higher than 0.90, the exergy destruction of the SNG

  4. Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1998 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    McLachlan, J.

    1998-06-01

    'The objective of this project is to determine how environmental contaminants, namely hydrocarbons, can act as hormones or anti-hormones (i.e., environmental hormones) in different species present in aquatic ecosystems. Species of particular focus are those which can serve as sentinel species (e.g., amphibians) and, thus, provide early warning signals for more widespread impacts on an ecosystem and its wildlife and human inhabitants. This reports the progress of 1.5 years of a three-year grant awarded to the Tulane/Xavier Center for Bioenvironmental Research (CBR). A growing body of evidence suggests that chemicals in the environment can disrupt the endocrine system of animals (i.e., wildlife and humans) and adversely impact the development of these species. Because of the multitude of known endocrine-disrupting chemicals and the numerous industrial and government sectors producing these chemicals, almost every federal agency has initiated research on the endocrine effects of chemicals relevant to their operations. This study represents the Department of Energy (DOE) Basic Energy Sciences'' only research on the impacts of endocrine-disrupting chemicals. The activities employed by this project to determine these impacts include development of biotechnology screens (in vitro), animal screens (in vivo), and other analyses of aquatic ecosystem biomarkers of exposure. The results from this study can elucidate how chemicals in the environment, including those from DOE activities, can signal (and alter) the development of a number of species in aquatic ecosystems. These signals can have detrimental impacts not only on an organismal level, but also on community, population, and entire ecosystem levels, including humans.'

  5. Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1998 annual progress report

    International Nuclear Information System (INIS)

    McLachlan, J.

    1998-01-01

    'The objective of this project is to determine how environmental contaminants, namely hydrocarbons, can act as hormones or anti-hormones (i.e., environmental hormones) in different species present in aquatic ecosystems. Species of particular focus are those which can serve as sentinel species (e.g., amphibians) and, thus, provide early warning signals for more widespread impacts on an ecosystem and its wildlife and human inhabitants. This reports the progress of 1.5 years of a three-year grant awarded to the Tulane/Xavier Center for Bioenvironmental Research (CBR). A growing body of evidence suggests that chemicals in the environment can disrupt the endocrine system of animals (i.e., wildlife and humans) and adversely impact the development of these species. Because of the multitude of known endocrine-disrupting chemicals and the numerous industrial and government sectors producing these chemicals, almost every federal agency has initiated research on the endocrine effects of chemicals relevant to their operations. This study represents the Department of Energy (DOE) Basic Energy Sciences'' only research on the impacts of endocrine-disrupting chemicals. The activities employed by this project to determine these impacts include development of biotechnology screens (in vitro), animal screens (in vivo), and other analyses of aquatic ecosystem biomarkers of exposure. The results from this study can elucidate how chemicals in the environment, including those from DOE activities, can signal (and alter) the development of a number of species in aquatic ecosystems. These signals can have detrimental impacts not only on an organismal level, but also on community, population, and entire ecosystem levels, including humans.'

  6. Mission analysis of photovoltaic solar energy systems. Quarterly progress report, December 1, 1975--February 29, 1976

    Energy Technology Data Exchange (ETDEWEB)

    None

    1976-03-01

    An appropriate methodology was developed for conducting the mainline activity of the task--a comprehensive survey of near-term (1976--1985) applications for photovoltaic solar energy conversion--and a start was made on the implementation of the methodology. The main emphasis of the first quarter of effort on the task, however, was placed on a quick, preliminary study aimed at the early identification of several promising near-term applications that would make attractive demonstration projects. Four such applications were identified: (a) impressed current corrosion protection of gas well casings, (b) impressed current corrosion protection of gas and oil pipelines, (c) railroad grade crossing signals, and (d) navigation aid buoys. Estimates were made, in each case, of the size of the associated potential market for photovoltaic arrays and of the break-even array price (the array price at which photovoltaic solar energy conversion would be economically competitive with alternative power sources). The estimated market sizes were as high as 1.1 MW/sub pk//yr (in the case of corrosion protection of deep gas wells) and break-even costs ranged from $2/W/sub pk/ to more than $50/W/sub pk/. A start was made on the examination of central station missions for photovoltaic power plants using very high concentration (concentration ratio approx. 1000). Progress was made on the adaptation of computer simulation routines for use in evaluating plant performance and on the computation of the effect of air mass variations on the efficiency of the GaAs cells that are likely to be used in this mission. Also, data on the various elements of social cost resulting from power production were collected from a wide variety of sources. A comprehensive literature search was conducted and supplementary information was obtained through contact with investigators who have studied the various specialized aspects of the overall problem.

  7. Comparative Analysis of Yeast Metabolic Network Models Highlights Progress, Opportunities for Metabolic Reconstruction.

    Directory of Open Access Journals (Sweden)

    Benjamin D Heavner

    2015-11-01

    Full Text Available We have compared 12 genome-scale models of the Saccharomyces cerevisiae metabolic network published since 2003 to evaluate progress in reconstruction of the yeast metabolic network. We compared the genomic coverage, overlap of annotated metabolites, predictive ability for single gene essentiality with a selection of model parameters, and biomass production predictions in simulated nutrient-limited conditions. We have also compared pairwise gene knockout essentiality predictions for 10 of these models. We found that varying approaches to model scope and annotation reflected the involvement of multiple research groups in model development; that single-gene essentiality predictions were affected by simulated medium, objective function, and the reference list of essential genes; and that predictive ability for single-gene essentiality did not correlate well with predictive ability for our reference list of synthetic lethal gene interactions (R = 0.159. We conclude that the reconstruction of the yeast metabolic network is indeed gradually improving through the iterative process of model development, and there remains great opportunity for advancing our understanding of biology through continued efforts to reconstruct the full biochemical reaction network that constitutes yeast metabolism. Additionally, we suggest that there is opportunity for refining the process of deriving a metabolic model from a metabolic network reconstruction to facilitate mechanistic investigation and discovery. This comparative study lays the groundwork for developing improved tools and formalized methods to quantitatively assess metabolic network reconstructions independently of any particular model application, which will facilitate ongoing efforts to advance our understanding of the relationship between genotype and cellular phenotype.

  8. [Research progress in water quality monitoring technology based on ultraviolet spectrum analysis].

    Science.gov (United States)

    Zeng, Tian-Ling; Wen, Zhi-Yu; Wen, Zhong-Quan; Zhang, Zhong-Wei; Wei, Kang-Lin

    2013-04-01

    The water quality monitoring technology based on ultraviolet spectrum analysis has the characteristics of small volume, low cost, and no secondary pollution, and it doesn't need any reagent and sample pretreatment. On account of these characteristics, the direct ultra-violet technology has remarkable superiority over traditional technologies when applied in online monitoring of drinking water, surface water and industrial wastewater, and it has become an important development tendency of modern water monitoring technologies. The principle, characteristics, present situation and development trend of modern water quality monitoring technology based on ultra-violet spectrum analysis were introduced, and the key technical problems were further discussed in this paper.

  9. Progress of laser ionization mass spectrometry for elemental analysis - A review of the past decade

    International Nuclear Information System (INIS)

    Lin Yiming; Yu Quan; Hang Wei; Huang Benli

    2010-01-01

    Mass spectrometry using a laser ionization source has played a significant role in elemental analysis. Three types of techniques are widely used: high irradiance laser ionization mass spectrometry is capable of rapid determination of elements in solids; single particle mass spectrometry is a powerful tool for single particle characterization; and resonance ionization mass spectrometry is applied for isotope ratio measurements with high sensitivity and selectivity. In this review, the main features of the laser ablation process and plasma characterization by mass spectrometry are summarized. Applications of these three techniques for elemental analysis are discussed.

  10. Current landscape of protein glycosylation analysis and recent progress toward a novel paradigm of glycoscience research.

    Science.gov (United States)

    Yamamoto, Sachio; Kinoshita, Mitsuhiro; Suzuki, Shigeo

    2016-10-25

    This review covers the basics and some applications of methodologies for the analysis of glycoprotein glycans. Analytical techniques used for glycoprotein glycans, including liquid chromatography (LC), capillary electrophoresis (CE), mass spectrometry (MS), and high-throughput analytical methods based on microfluidics, were described to supply the essentials about biopharmaceutical and biomarker glycoproteins. We will also describe the MS analysis of glycoproteins and glycopeptides as well as the chemical and enzymatic releasing methods of glycans from glycoproteins and the chemical reactions used for the derivatization of glycans. We hope the techniques have accommodated most of the requests from glycoproteomics researchers. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. California geothermal resource development environmental implications for ERCDC Environmental Analysis Office. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, J.A.

    1977-02-01

    The results of an analysis of the environmental implications for ERCDC Environmental Analysis Office (EAO) in relation to the development of California's geothermal resources are reported. While focusing primarily on environmental implications, particularly the natural, social, and economic elements, the report includes some ERCDC-wide policy and program considerations. The primary thrusts of the work have been in the development of an understanding of the interagency and intergovernmental environmental data and data-management roles and responsibilities and in the formulation of recommendations related thereto. Five appendices are included, one of which is a tax credit agreement between a power company and Skagit County, Washington. (JGB)

  12. Hearing on Systems Analysis for Final Disposal of Nuclear Waste? A report from hearings at the Council April 24 2008

    International Nuclear Information System (INIS)

    2009-01-01

    Various parties, especially government authorities and Oskarshamn municipality has during a number of years, made demands for SKB to develop a systems analysis program for their next application. Discussions have been held on its purpose and content, and different assessments has emerged. SKB says that a systems analysis as a separate part of the application does not fulfill any function since its various parts are specified in other documents included in base for final application, such as the EIS (MKB) and safety analysis. The authorities have stated that it will not require a specific systems analysis, provided that SKB can show that information can be found elsewhere in the application dossier. On April 24, 2008, the Nuclear Waste Council held a hearing in the role of systems analysis in the nuclear waste issue. The purpose of the hearing was to contribute to knowledge building on methods for systems analysis and how it can be used to analyze the nuclear waste problem and to clarify how SKB intends to meet the requirements previously set to a systems analysis

  13. Progressive Trends and Impact of the Journal of Career Development: A Citation Analysis

    Science.gov (United States)

    Chaichanasakul, Adipat; He, Yuhong; Chen, Hsui-Hui; Allen, G. E. Kawika; Khairallah, Taleb S.; Ramos, Karina

    2011-01-01

    As one of the four premier journals in vocational psychology, the "Journal of Career Development" ("JCD") has published over 830 articles over the past three decades. This study examined the performance of "JCD" through a citation analysis and provided evaluative data for scholars publishing in the field of vocation psychology. Articles published…

  14. Research in progress in applied mathematics, numerical analysis, and computer science

    Science.gov (United States)

    1990-01-01

    Research conducted at the Institute in Science and Engineering in applied mathematics, numerical analysis, and computer science is summarized. The Institute conducts unclassified basic research in applied mathematics in order to extend and improve problem solving capabilities in science and engineering, particularly in aeronautics and space.

  15. Genome sequencing and analysis conferences. Progress report, August 15, 1993--August 15, 1994

    Energy Technology Data Exchange (ETDEWEB)

    Venter, J.C.

    1995-10-01

    The 14 plenary session presentations focused on nematode; yeast; fruit fly; plants; mycobacteria; and man. In addition there were presentations on a variety of technical innovations including database developments and refinements, bioelectronic genesensors, computer-assisted multiplex techniques, and hybridization analysis with DNA chip technology. This document includes only the session schedule.

  16. Safety analysis of the transportation of radioactive waste to the Konrad final repository

    International Nuclear Information System (INIS)

    Sentuc, F.N.; Bruecher, W.

    2010-01-01

    A transport risk assessment study has been conducted for transport of radioactive waste with negligible heat-generation to the German final repository Konrad. This study is a revision of the former Konrad Transport Study performed by GRS in 1991 implementing updated waste data among other improved methods and assumptions for the purpose of a more realistic approach to risk assessment. The first part of the transport risk assessment study concerns the radiological consequences from normal (accident-free) transportation of radioactive material, i.e. the radiation exposure of transport personnel and the public. Based on the assessed detailed information on transport arrangements and on the average number and radiological characteristics of waste packages the maximum annual effective doses for the representative persons were estimated. The risk associated with transport incidents and accidents has been quantified for the area within a radius of 25 km around the repository site. The probabilistic method adopted in this study considers parameters as the frequency and severity of railway or road accidents, characteristics of radioactive waste and transport packagings and the frequency of atmospheric dispersion conditions. From a large set of parameter combinations the spectrum of potential radiological consequences and of the associated probability of occurrence was assessed. (orig.)

  17. Final Harvest of Above-Ground Biomass and Allometric Analysis of the Aspen FACE Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Mark E. Kubiske

    2013-04-15

    The Aspen FACE experiment, located at the US Forest Service Harshaw Research Facility in Oneida County, Wisconsin, exposes the intact canopies of model trembling aspen forests to increased concentrations of atmospheric CO2 and O3. The first full year of treatments was 1998 and final year of elevated CO2 and O3 treatments is scheduled for 2009. This proposal is to conduct an intensive, analytical harvest of the above-ground parts of 24 trees from each of the 12, 30 m diameter treatment plots (total of 288 trees) during June, July & August 2009. This above-ground harvest will be carefully coordinated with the below-ground harvest proposed by D.F. Karnosky et al. (2008 proposal to DOE). We propose to dissect harvested trees according to annual height growth increment and organ (main stem, branch orders, and leaves) for calculation of above-ground biomass production and allometric comparisons among aspen clones, species, and treatments. Additionally, we will collect fine root samples for DNA fingerprinting to quantify biomass production of individual aspen clones. This work will produce a thorough characterization of above-ground tree and stand growth and allocation above ground, and, in conjunction with the below ground harvest, total tree and stand biomass production, allocation, and allometry.

  18. Environmental Technology (Laboratory Analysis and Environmental Sampling) Curriculum Development Project. Final Report.

    Science.gov (United States)

    Hinojosa, Oscar V.; Guillen, Alfonso

    A project assessed the need and developed a curriculum for environmental technology (laboratory analysis and environmental sampling) in the emerging high technology centered around environmental safety and health in Texas. Initial data were collected through interviews by telephone and in person and through onsite visits. Additional data was…

  19. X-ray fluorescence analysis study. Final report, December 1, 1970-December 31, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Kneip, T J; Laurer, G R

    1978-01-01

    This report has described the most significant experiments and the results obtained, during the development of a system for the detection and measurement of Pb in blood using radioisotope-excited x-ray fluorescence analysis, over the contract period. Briefly, the report described: detector selection; source selection; source-sample-detector geometry; sample preparation; system calibration; and separation technique. (PSB)

  20. Regulatory impact analysis of the proposed great lakes water quality guidance. Final report

    International Nuclear Information System (INIS)

    Raucher, R.; Dixon, A.; Trabka, E.

    1993-01-01

    The Regulatory Impact Analysis provides direction to the Great Lakes States and Tribes on minimum water quality standards and contains numerical water quality criteria for 32 pollutants as well as methodologies for the development of water quality criteria for additional pollutants discharged to these waters. It also provides guidance to the Great Lakes States and Tribes on antidegradation policies and standards and implementation procedures

  1. Development of design parameters for mass concrete using finite element analysis : final report, February 2010.

    Science.gov (United States)

    2010-02-01

    A finite element model for analysis of mass concrete was developed in this study. To validate the developed model, large concrete blocks made with four different mixes of concrete, typical of use in mass concrete applications in Florida, were made an...

  2. Human Factors Analysis of Pipeline Monitoring and Control Operations: Final Technical Report

    Science.gov (United States)

    2008-11-26

    The purpose of the Human Factors Analysis of Pipeline Monitoring and Control Operations project was to develop procedures that could be used by liquid pipeline operators to assess and manage the human factors risks in their control rooms that may adv...

  3. Analysis and comparison of biomass pyrolysis/gasification condensates: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, D.C.

    1986-06-01

    This report provides results of chemical and physical analysis of condensates from eleven biomass gasification and pyrolysis systems. The samples were representative of the various reactor configurations being researched within the Department of Energy, Biomass Thermochemical Conversion program. The condensates included tar phases and aqueous phases. The analyses included gross compositional analysis (elemental analysis, ash, moisture), physical characterization (pour point, viscosity, density, heat of combustion, distillation), specific chemical analysis (gas chromatography/mass spectrometry, infrared spectrophotometry, proton and carbon-13 nuclear magnetic resonance spectrometry) and biological activity (Ames assay and mouse skin tumorigenicity tests). These results are the first step of a longer term program to determine the properties, handling requirements, and utility of the condensates recovered from biomass gasification and pyrolysis. The analytical data demonstrates the wide range of chemical composition of the organics recovered in the condensates and suggests a direct relationship between operating temperature and chemical composition of the condensates. A continuous pathway of thermal degradation of the tar components as a function of temperature is proposed. Variations in the chemical composition of the organic components in the tars are reflected in the physical properties of tars and phase stability in relation to water in the condensate. The biological activity appears to be limited to the tars produced at high temperatures. 56 refs., 25 figs., 21 tabs.

  4. Operations research and systems analysis of geopressured/geothermal resources in Texas. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lesso, W.G.; Zinn, C.D.; Cornwell, J.

    1981-05-01

    A preliminary resource assessment, based on the best available parameters, was made to identify potentially suitable fairways. Of those examined only the Brazoria Fairway in the Frio Formation was able to produce sufficient fluid to meet the minimum requirements. These requirements are based upon the need for a well to produce an initial flow rate of 40,000 bbl/day with a 6% decline rate over a 30 year production period. Next, a development planning analysis was done to determine the number of wells that would have to be drilled in the fairway, considering the probability of success, and the number of drilling rigs available. The results of this analysis provided a time phased scenario and costs of developing the fairway. These were next used in an economic analysis. The economic analysis was performed to determine the present worth of using the resource under a range of values for the key economic parameters. The results of this study indicate that the commercial development of geopressured, geothermal resource is highly dependent upon the pricing of natural gas in the US, the development of tax incentives to spur development, and a better understanding of the nature of the resource through additional well tests.

  5. Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis.

    Science.gov (United States)

    Richardson, Timothy E; Snuderl, Matija; Serrano, Jonathan; Karajannis, Matthias A; Heguy, Adriana; Oliver, Dwight; Raisanen, Jack M; Maher, Elizabeth A; Pan, Edward; Barnett, Samuel; Cai, Chunyu; Habib, Amyn A; Bachoo, Robert M; Hatanpaa, Kimmo J

    2017-05-01

    According to the recently updated World Health Organization (WHO) classification (2016), grade II-III astrocytomas are divided into IDH-wildtype and IDH-mutant groups, the latter being significantly less aggressive in terms of both progression-free and total survival. We identified a small cohort of WHO grade II-III astrocytomas that harbored the IDH1 R132H mutation, as confirmed by both immunohistochemistry and molecular sequence analysis, which nonetheless had unexpectedly rapid recurrence and subsequent progression to glioblastoma. Among these four cases, the mean time to recurrence as glioblastoma was only 16 months and the mean total survival among the three patients who have died during the follow-up was only 31 months. We hypothesized that these tumors had other, unfavorable genetic or epigenetic alterations that negated the favorable effect of the IDH mutation. We applied genome-wide profiling with a methylation array (Illumina Infinium Human Methylation 450k) to screen for genetic and epigenetic alterations in these tumors. As expected, the methylation profiles of all four tumors were found to match most closely with IDH-mutant astrocytomas. Compared with a control group of four indolent, age-similar WHO grade II-III astrocytomas, the tumors showed markedly increased levels of overall copy number changes, but no consistent specific genetic alterations were seen across all of the tumors. While most IDH-mutant WHO grade II-III astrocytomas are relatively indolent, a subset may rapidly recur and progress to glioblastoma. The precise underlying cause of the increased aggressiveness in these gliomas remains unknown, although it may be associated with increased genomic instability.

  6. On the partial-wave analysis of mesonic resonances decaying to multiparticle final states produced by polarized photons

    Science.gov (United States)

    Salgado, Carlos W.; Weygand, Dennis P.

    2014-04-01

    Meson spectroscopy is going through a revival with the advent of high statistics experiments and new advances in the theoretical predictions. The Constituent Quark Model (CQM) is finally being expanded considering more basic principles of field theory and using discrete calculations of Quantum Chromodynamics (lattice QCD). These new calculations are approaching predictive power for the spectrum of hadronic resonances and decay modes. It will be the task of the new experiments to extract the meson spectrum from the data and compare with those predictions. The goal of this report is to describe one particular technique for extracting resonance information from multiparticle final states. The technique described here, partial wave analysis based on the helicity formalism, has been used at Brookhaven National Laboratory (BNL) using pion beams, and Jefferson Laboratory (JLab) using photon beams. In particular this report broadens this technique to include production experiments using linearly polarized real photons or quasi-real photons. This article is of a didactical nature. We describe the process of analysis, detailing assumptions and formalisms, and is directed towards people interested in starting partial wave analysis.

  7. On the Partial-Wave Analysis of Mesonic Resonances Decaying to Multiparticle Final States Produced by Polarized Photons

    Energy Technology Data Exchange (ETDEWEB)

    Salgado, Carlos W. [Norfolk State University, Norfolk, VA (United States) and Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Weygand, Dennis P. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

    2014-04-01

    Meson spectroscopy is going through a revival with the advent of high statistics experiments and new advances in the theoretical predictions. The Constituent Quark Model (CQM) is finally being expanded considering more basic principles of field theory and using discrete calculations of Quantum Chromodynamics (lattice QCD). These new calculations are approaching predictive power for the spectrum of hadronic resonances and decay modes. It will be the task of the new experiments to extract the meson spectrum from the data and compare with those predictions. The goal of this report is to describe one particular technique for extracting resonance information from multiparticle final states. The technique described here, partial wave analysis based on the helicity formalism, has been used at Brookhaven National Laboratory (BNL) using pion beams, and Jefferson Laboratory (Jlab) using photon beams. In particular this report broaden this technique to include production experiments using linearly polarized real photons or quasi-real photons. This article is of a didactical nature. We describe the process of analysis, detailing assumptions and formalisms, and is directed towards people interested in starting partial wave analysis.

  8. Multivariate analysis of the cleaning efficacy of different final irrigation techniques in the canal and isthmus of mandibular posterior teeth

    Directory of Open Access Journals (Sweden)

    Yeon-Jee Yoo

    2013-08-01

    Full Text Available Objectives The aim of this study was to compare the cleaning efficacy of different final irrigation regimens in canal and isthmus of mandibular molars, and to evaluate the influence of related variables on cleaning efficacy of the irrigation systems. Materials and Methods Mesial root canals from 60 mandibular molars were prepared and divided into 4 experimental groups according to the final irrigation technique: Group C, syringe irrigation; Group U, ultrasonics activation; Group SC, VPro StreamClean irrigation; Group EV, EndoVac irrigation. Cross-sections at 1, 3 and 5 mm levels from the apex were examined to calculate remaining debris area in the canal and isthmus spaces. Statistical analysis was completed by using Kruskal-Wallis test and Mann-Whitney U test for comparison among groups, and multivariate linear analysis to identify the significant variables (regular replenishment of irrigant, vapor lock management, and ultrasonic activation of irrigant affecting the cleaning efficacy of the experimental groups. Results Group SC and EV showed significantly higher canal cleanliness values than group C and U at 1 mm level (p < 0.05, and higher isthmus cleanliness values than group U at 3 mm and all levels of group C (p < 0.05. Multivariate linear regression analysis demonstrated that all variables had independent positive correlation at 1 mm level of canal and at all levels of isthmus with statistical significances. Conclusions Both VPro StreamClean and EndoVac system showed favorable result as final irrigation regimens for cleaning debris in the complicated root canal system having curved canal and/or isthmus. The debridement of the isthmi significantly depends on the variables rather than the canals.

  9. Growth curve analysis for plasma profiles using smoothing splines. Final report, January 1993--January 1995

    International Nuclear Information System (INIS)

    Imre, K.

    1995-07-01

    In this project, we parameterize the shape and magnitude of the temperature and density profiles on JET and the temperature profiles on TFTR. The key control variables for the profiles were tabulated and the response functions were estimated. A sophisticated statistical analysis code was developed to fit the plasma profiles. Our analysis indicate that the JET density shape depends primarily on bar n/B t for Ohmic heating, bar n for L-mode and I p for H-mode. The temperature profiles for JET are mainly determined by q 95 for the case of Ohmic heating, and by B t and P/bar n for the L-mode. For the H-mode the shape depends on the type of auxiliary heating, Z eff , N bar n, q 95 , and P

  10. An economic analysis of a monitored retrievable storage site for Tennessee. Final report and appendices

    Energy Technology Data Exchange (ETDEWEB)

    Fox, W.F.; Mayo, J.W.; Hansen, L.T.; Quindry, K.E.

    1985-12-17

    The United States Department of Energy is charged with the task of identifying potential sites for a Monitored Retrievable Storage (MRS) Facility and reporting the results of its analysis to Congress by January 1986. DOE chose three finalist sites from 11 sites DOE analysts evaluated earlier. All three are in Tennessee, including two in Oak Ridge and one in Trousdale/Smith Counties. This paper is a summary of research undertaken on the economic effects of establishing the MRS facility in Tennessee. All three locations were considered in the analysis, but on some occasions attention is focused on the site preferred by DOE. The research was undertaken by the Center for Business and Economic Research (CBER), College of Business Administration, the University of Tennessee, Knoxville, under contract with the Tennessee Department of Economic and Community Development.

  11. Vibration signal analysis for gear fault diagnosis with various crack progression scenarios

    Science.gov (United States)

    Mohammed, Omar D.; Rantatalo, Matti; Aidanpää, Jan-Olov; Kumar, Uday

    2013-12-01

    There are different analytical scenarios assumed for crack propagation in the gear tooth root. This paper presents an investigation of the performance of statistical fault detection indicators (the RMS and kurtosis) for three different series of crack propagation scenarios, to compare these scenarios from a fault diagnostics point of view. These scenarios imply different forms of cracks with propagation by a certain step of crack depth. The first scenario assumes a crack being extended through the whole tooth width with a uniform crack depth distribution, while the second scenario assumes the crack being extended through the whole tooth width with a parabolic crack depth distribution, and finally in the third scenario the crack is assumed to be propagating in both the depth and the length directions simultaneously. The time-varying gear mesh stiffness has been investigated using the programme code developed in the present research, and the crack propagation can be modelled with any of the presented crack propagation scenarios. Dynamic simulation has been performed to obtain the residual signals of all the studied cases for each crack propagation scenario. The comparison of the statistical indicators applied to the residual signals shows that in the first scenario the faults are most easily detectable, since in this scenario there is a change in the indicators implying a dramatic decrease in the gear mesh stiffness. The fault detection in the 2nd scenario is more difficult, as the crack propagates with no significant reflection on the mesh stiffness loss. The 3rd proposed scenario should receive more attention in research because it could occur in reality in case of non-uniform load distribution. However, with this scenario it is difficult to perform early fault detection, since there is a very slight change in the statistical indicators at the beginning of the crack propagation. After which, these indicators show a significant change when the crack grows deeper

  12. Innovative Method of Analysis of Actual Cost of Work in Progress

    Science.gov (United States)

    Fil, O.; Terentev, V.

    2017-11-01

    The article focuses on the basic theory and practical aspects of improving the strategic management in terms of enhancing the quality of a technological process: these aspects have been proven experimentally by their introduction in company operations. The authors have worked out some proposals aimed at selecting an optimal supplier for building companies as well as the algorithm for the analysis and optimization of a construction company basing on scientific and practical research and the experimental data obtained in the experiment

  13. GAT 3 - fuel cells and their management (PACoGES). Progress report; GAT 3 - piles a combustible et leur gestion (PACoGES). Rapport final (juillet 2002 a juin 2004)

    Energy Technology Data Exchange (ETDEWEB)

    Lamy, C.

    2005-07-01

    The Topic Analysis Group PACoGES ('Piles a Combustible et leur Gestion') has conducted thoughts on fuel cells and their management with all the searchers concern with researches and developments on fuel cells and in particular on solid oxide fuel cells (SOFC, ITSOFC) running at high temperature (600 to 1000 C). This has concerned about 200 searchers working in about fifty laboratories (CNRS, CEA, EDF, GDF, INRETS, CNAM, Armines, and several industrial teams). Here is given the final report 2002-2004 concerning all the researches carried out by this Group. (O.M.)

  14. Toward an Integrated BAC Library Resource for Genome Sequencing and Analysis; FINAL

    International Nuclear Information System (INIS)

    Simon, M. I.; Kim, U.-J.

    2002-01-01

    We developed a great deal of expertise in building large BAC libraries from a variety of DNA sources including humans, mice, corn, microorganisms, worms, and Arabidopsis. We greatly improved the technology for screening these libraries rapidly and for selecting appropriate BACs and mapping BACs to develop large overlapping contigs. We became involved in supplying BACs and BAC contigs to a variety of sequencing and mapping projects and we began to collaborate with Drs. Adams and Venter at TIGR and with Dr. Leroy Hood and his group at University of Washington to provide BACs for end sequencing and for mapping and sequencing of large fragments of chromosome 16. Together with Dr. Ian Dunham and his co-workers at the Sanger Center we completed the mapping and they completed the sequencing of the first human chromosome, chromosome 22. This was published in Nature in 1999 and our BAC contigs made a major contribution to this sequencing effort. Drs. Shizuya and Ding invented an automated highly accurate BAC mapping technique. We also developed long-term collaborations with Dr. Uli Weier at UCSF in the design of BAC probes for characterization of human tumors and specific chromosome deletions and breakpoints. Finally the contribution of our work to the human genome project has been recognized in the publication both by the international consortium and the NIH of a draft sequence of the human genome in Nature last year. Dr. Shizuya was acknowledged in the authorship of that landmark paper. Dr. Simon was also an author on the Venter/Adams Celera project sequencing the human genome that was published in Science last year

  15. Social networking and the Olympic Movement: social media analysis, opportunities and trends : final report

    OpenAIRE

    Fernández Peña, Emilio

    2011-01-01

    Table of contents : 1: Introduction. - 2 : Sociodemographic data of social networking sites. - 3 : The Vancouver 2010 Olympic Winter Games on Facebook, Twitter and Orkut. - 4 : Singapore 2010 Youth Olympic Games communication strategies on Facebook and Twitter. - 5 : Sport organizations social networking strategies : case study analysis. - 6 : Olympic athletes and social media use during a non olympic-period. - 7. The Olympic Games, NBA and FC Barcelona on Facebook : content and fan participa...

  16. Geological storage of CO2: risks analysis, monitoring and measures. Final report

    International Nuclear Information System (INIS)

    Abou Akar, A.; Audibert, N.; Audigane, P.; Baranger, P.; Bonijoly, D.; Carnec, C.; Czernichowski, I.; Debeglia, N.; Fabriol, H.; Foerster, E.; Gaus, I.; Le Nindre, Y.; Michel, K.; Morin, D.; Roy, S.; Sanjuan, B.; Sayedi, D.

    2005-01-01

    To use the CO 2 geological storage as a coherent solution in the greenhouse gases reduction it needs to answer to safety and monitoring conditions. In this framework the BRGM presents this study in six chapters: risks analysis, the monitoring methods (geochemistry, geophysics, aerial monitoring, biochemistry, hydrogeology), the metrology, the corrosion problems, the thermal, hydrodynamical, geochemical and mechanical simulation and the today and future regulations. (A.L.B.)

  17. Final safety analysis report (FSAR) for waste receiving and processing (WRAP) facility

    International Nuclear Information System (INIS)

    Weidert, J.R.

    1997-01-01

    This safety analysis report provides a summary description of the WRAP Facility, focusing on significant safety-related characteristics of the location and facility design. This report demonstrates that adherence to the safety basis wi11 ensure necessary operational safety considerations have been addressed sufficiently and justifies the adequacy of the safety basis in protecting the health and safety of the public, workers, and the environment

  18. Final Technical Report: Advanced Measurement and Analysis of PV Derate Factors.

    Energy Technology Data Exchange (ETDEWEB)

    King, Bruce Hardison [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Burton, Patrick D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hansen, Clifford [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Christian Birk [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    The Advanced Measurement and Analysis of PV Derate Factors project focuses on improving the accuracy and reducing the uncertainty of PV performance model predictions by addressing a common element of all PV performance models referred to as “derates”. Widespread use of “rules of thumb”, combined with significant uncertainty regarding appropriate values for these factors contribute to uncertainty in projected energy production.

  19. Cryogenic laser calorimetry for impurity analysis. Final report, September 6, 1983-December 1, 1984

    Energy Technology Data Exchange (ETDEWEB)

    Swimm, R.T.

    1985-05-01

    This report presents the results of a one-year effort to determine the applicability of laser-calorimetric spectroscopy to the study of deep-level impurities in silicon. Critical considerations for impurity analysis by laser-calorimetric spectroscopy are discussed, the design and performance of a cryogenic laser calorimeter is described, and measurements of background absorption in high-purity silicon are presented.

  20. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    R Paul Drake

    2004-01-12

    OAK-B135 This is the final report from the project Hydrodynamics by High-Energy-Density Plasma Flow and Hydrodynamics and Radiation Hydrodynamics with Astrophysical Applications. This project supported a group at the University of Michigan in the invention, design, performance, and analysis of experiments using high-energy-density research facilities. The experiments explored compressible nonlinear hydrodynamics, in particular at decelerating interfaces, and the radiation hydrodynamics of strong shock waves. It has application to supernovae, astrophysical jets, shock-cloud interactions, and radiative shock waves.

  1. An automated system for the analysis of peri-prosthetic osteolysis progression

    Science.gov (United States)

    Tamez-Pena, Jose; Barbu-McInnis, Monica; Pakin, S. Kubilay; Castaneda, Benjamin; Totterman, Saara; Looney, R. John

    2008-03-01

    The purpose of this work is to evaluate the performance of a computer based analysis system aimed at the quantitative detection of changes in hip osteolytic lesions in subjects with hip implants. The computer system is based on the supervised segmentation of a baseline x-ray computed-tomography (CT) scan and an automated segmentation of a follow-up CT scan using an object based tracking algorithm. The segmentation process outlines the pelvic bone and lesions present in the pelvis. The size and CT density of the osteolytic lesions are computed in both baseline and follow-up segmentations and the change in both these quantities are evaluated. The system analysis consisted of the direct comparison of the quantitative results obtained from an expert manual segmentation to the quantitative results obtained using the automated system on 20 subjects. The system bias was evaluated by performing forwards and backwards analysis of the CT data. Furthermore, the stability of the proposed tracking system was compared to the variability of the manual tracking. The results show that the system enhances the human ability to detect changes in lesions size and density regardless of the inherent observer variability in the definition of the baseline manual segmentation.

  2. Continuum Damage Mechanics Models for the Analysis of Progressive Failure in Open-Hole Tension Laminates

    Science.gov (United States)

    Song, Kyonchan; Li, Yingyong; Rose, Cheryl A.

    2011-01-01

    The performance of a state-of-the-art continuum damage mechanics model for interlaminar damage, coupled with a cohesive zone model for delamination is examined for failure prediction of quasi-isotropic open-hole tension laminates. Limitations of continuum representations of intra-ply damage and the effect of mesh orientation on the analysis predictions are discussed. It is shown that accurate prediction of matrix crack paths and stress redistribution after cracking requires a mesh aligned with the fiber orientation. Based on these results, an aligned mesh is proposed for analysis of the open-hole tension specimens consisting of different meshes within the individual plies, such that the element edges are aligned with the ply fiber direction. The modeling approach is assessed by comparison of analysis predictions to experimental data for specimen configurations in which failure is dominated by complex interactions between matrix cracks and delaminations. It is shown that the different failure mechanisms observed in the tests are well predicted. In addition, the modeling approach is demonstrated to predict proper trends in the effect of scaling on strength and failure mechanisms of quasi-isotropic open-hole tension laminates.

  3. Recent progress and challenges in nanotechnology for biomedical applications: an insight into the analysis of neurotransmitters.

    Science.gov (United States)

    Shankaran, Dhesingh Ravi; Miura, Norio

    2007-01-01

    Nanotechnology offers exciting opportunities and unprecedented compatibilities in manipulating chemical and biological materials at the atomic or molecular scale for the development of novel functional materials with enhanced capabilities. It plays a central role in the recent technological advances in biomedical technology, especially in the areas of disease diagnosis, drug design and drug delivery. In this review, we present the recent trend and challenges in the development of nanomaterials for biomedical applications with a special emphasis on the analysis of neurotransmitters. Neurotransmitters are the chemical messengers which transform information and signals all over the body. They play prime role in functioning of the central nervous system (CNS) and governs most of the metabolic functions including movement, pleasure, pain, mood, emotion, thinking, digestion, sleep, addiction, fear, anxiety and depression. Thus, development of high-performance and user-friendly analytical methods for ultra-sensitive detection of neurotransmitters remain a major challenge in modern biomedical analysis. Nanostructured materials are emerging as a powerful mean for diagnosis of CNS disorders because of their unique optical, size and surface characteristics. This review provides a brief outline on the basic concepts and recent advancements of nanotechnology for biomedical applications, especially in the analysis of neurotransmitters. A brief introduction to the nanomaterials, bionanotechnology and neurotransmitters is also included along with discussions on most of the patents published in these areas.

  4. Final safety analysis report for the Ground Test Accelerator (GTA), Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-10-01

    This document is the second volume of a 3 volume safety analysis report on the Ground Test Accelerator (GTA). The GTA program at the Los Alamos National Laboratory (LANL) is the major element of the national Neutral Particle Beam (NPB) program, which is supported by the Strategic Defense Initiative Office (SDIO). A principal goal of the national NPB program is to assess the feasibility of using hydrogen and deuterium neutral particle beams outside the Earth`s atmosphere. The main effort of the NPB program at Los Alamos concentrates on developing the GTA. The GTA is classified as a low-hazard facility, except for the cryogenic-cooling system, which is classified as a moderate-hazard facility. This volume consists of failure modes and effects analysis; accident analysis; operational safety requirements; quality assurance program; ES&H management program; environmental, safety, and health systems critical to safety; summary of waste-management program; environmental monitoring program; facility expansion, decontamination, and decommissioning; summary of emergency response plan; summary plan for employee training; summary plan for operating procedures; glossary; and appendices A and B.

  5. Photovoltaic power systems market identification and analysis. Final report, January 1977--February 1978

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-01

    This report summarizes the work done by InterTechnology/Solar Corporation, its consultants, Mobil Tyco Solar Energy Corporation and the University of Delaware Institute for Energy Conversion, and its consultants, during the marketing analysis of near and intermediate term photovoltaic power applications. To obtain estimates of the domestic and foreign market potential for photovoltaically powered devices two approaches were used. First, the study was identifying then screening all possible photovoltaic power supply applications. This approach encompassed the first two tasks of the study: (1) a survey of the current uses of photovoltaic systems, both domestic and international, and a projection of the usage of those systems into the future; and (2) a new idea generation task which attempted to come up with new ways of using photovoltaic power. Second, the study required in-depth analysis of key near-term and intermediate-term photovoltaic applications identified during the first phase to obtain reasonable estimates of photovoltaic market potential. This process encompassed the third and fourth tasks of the analysis: (3) refinement of ideas generated in Task 2 so that certain products/applications could be identified, the product defined and a market survey carried out; and (4) development of a detailed product scenario which forecasts sales, barriers to market acceptance, and technical innovationsrequired for proper introduction of the products. The work performed and findings of each task are presented.

  6. Materials, process, product analysis of coal process technology. Phase I final report

    Energy Technology Data Exchange (ETDEWEB)

    Saxton, J. C.; Roig, R. W.; Loridan, A.; Leggett, N. E.; Capell, R. G.; Humpstone, C. C.; Mudry, R. N.; Ayres, E.

    1976-02-01

    The purpose of materials-process-product analysis is a systematic evaluation of alternative manufacturing processes--in this case processes for converting coal into energy and material products that can supplement or replace petroleum-based products. The methodological steps in the analysis include: Definition of functional operations that enter into coal conversion processes, and modeling of alternative, competing methods to accomplish these functions; compilation of all feasible conversion processes that can be assembled from combinations of competing methods for the functional operations; systematic, iterative evaluation of all feasible conversion processes under a variety of economic situations, environmental constraints, and projected technological advances; and aggregative assessments (economic and environmental) of various industrial development scenarios. An integral part of the present project is additional development of the existing computer model to include: A data base for coal-related materials and coal conversion processes; and an algorithmic structure that facilitates the iterative, systematic evaluations in response to exogenously specified variables, such as tax policy, environmental limitations, and changes in process technology and costs. As an analytical tool, the analysis is intended to satisfy the needs of an analyst working at the process selection level, for example, with respect to the allocation of RDandD funds to competing technologies.

  7. Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-05-19

    A partnership across government, academic, and private sectors has created a novel system that enables climate researchers to solve current and emerging data analysis and visualization challenges. The Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) software project utilizes the Python application programming interface (API) combined with C/C++/Fortran implementations for performance-critical software that offers the best compromise between "scalability" and “ease-of-use.” The UV-CDAT system is highly extensible and customizable for high-performance interactive and batch visualization and analysis for climate science and other disciplines of geosciences. For complex, climate data-intensive computing, UV-CDAT’s inclusive framework supports Message Passing Interface (MPI) parallelism as well as taskfarming and other forms of parallelism. More specifically, the UV-CDAT framework supports the execution of Python scripts running in parallel using the MPI executable commands and leverages Department of Energy (DOE)-funded general-purpose, scalable parallel visualization tools such as ParaView and VisIt. This is the first system to be successfully designed in this way and with these features. The climate community leverages these tools and others, in support of a parallel client-server paradigm, allowing extreme-scale, server-side computing for maximum possible speed-up.

  8. THE ECONOMIC ANALYSIS OF LAW - WILL THE ROMANIAN DOCTRINE FINALLY CATCH UP WITH IT?

    Directory of Open Access Journals (Sweden)

    MONICA-FLORENTINA POPA

    2013-05-01

    Full Text Available Although a well-established presence on the international legal scene, the economic analysis of law is still an unfamiliar concept to most Romanian scholars. While worldwide, prestigious universities offer special courses on this topic and an impressive body of legal studies continues to add up, only scant traces of this important legal school can be detected in some recent Romanian doctoral thesis and papers. This article explores the main concepts of the economic analysis of law, the recent spin-offs of this theory, especially in the area of comparative law, as well as some of the critiques addressed in the legal doctrine, concerning the consequences on law of overemphasizing “efficiency” to the expense of less quantifiable, moral and social considerations. Some explanations on why the Romanian doctrine is lagging behind with respect to the economic analysis of law will also be attempted, together with a tentative answer to whether this major legal theory will ever make an impact on local doctrinal developments in the near future.

  9. Final Report Scalable Analysis Methods and In Situ Infrastructure for Extreme Scale Knowledge Discovery

    Energy Technology Data Exchange (ETDEWEB)

    O' Leary, Patrick [Kitware, Inc., Clifton Park, NY (United States)

    2017-09-13

    The primary challenge motivating this project is the widening gap between the ability to compute information and to store it for subsequent analysis. This gap adversely impacts science code teams, who can perform analysis only on a small fraction of the data they calculate, resulting in the substantial likelihood of lost or missed science, when results are computed but not analyzed. Our approach is to perform as much analysis or visualization processing on data while it is still resident in memory, which is known as in situ processing. The idea in situ processing was not new at the time of the start of this effort in 2014, but efforts in that space were largely ad hoc, and there was no concerted effort within the research community that aimed to foster production-quality software tools suitable for use by Department of Energy (DOE) science projects. Our objective was to produce and enable the use of production-quality in situ methods and infrastructure, at scale, on DOE high-performance computing (HPC) facilities, though we expected to have an impact beyond DOE due to the widespread nature of the challenges, which affect virtually all large-scale computational science efforts. To achieve this objective, we engaged in software technology research and development (R&D), in close partnerships with DOE science code teams, to produce software technologies that were shown to run efficiently at scale on DOE HPC platforms.

  10. Final Safety Analysis Document for Building 693 Chemical Waste Storage Building at Lawrence Livermore National Laboratory

    International Nuclear Information System (INIS)

    Salazar, R.J.; Lane, S.

    1992-02-01

    This Safety Analysis Document (SAD) for the Lawrence Livermore National Laboratory (LLNL) Building 693, Chemical Waste Storage Building (desipated as Building 693 Container Storage Unit in the Laboratory's RCRA Part B permit application), provides the necessary information and analyses to conclude that Building 693 can be operated at low risk without unduly endangering the safety of the building operating personnel or adversely affecting the public or the environment. This Building 693 SAD consists of eight sections and supporting appendices. Section 1 presents a summary of the facility designs and operations and Section 2 summarizes the safety analysis method and results. Section 3 describes the site, the facility desip, operations and management structure. Sections 4 and 5 present the safety analysis and operational safety requirements (OSRs). Section 6 reviews Hazardous Waste Management's (HWM) Quality Assurance (QA) program. Section 7 lists the references and background material used in the preparation of this report Section 8 lists acronyms, abbreviations and symbols. Appendices contain supporting analyses, definitions, and descriptions that are referenced in the body of this report

  11. Design rules of mechanical structure of reactors. Damage due to cyclic loading. Progressive distortion. Practical analysis of ratcheting

    International Nuclear Information System (INIS)

    Clement, Gerard; Cousseran, Pierre; Lebey, Jacques; Moulin, Didier; Roche, Roland; Tremblais, Andre.

    1982-08-01

    At first is given a definition of what is ratcheting. A short discussion shows that computation results do not agree with experimental results. This is attributed to the complexity of the real material behavior. These considerations lead to try to build a design rule mainly based on the results of experimental tests. A large experimental program is in progress at CEN-Saclay. Using these results and the results available in open litterature, it was possible to propose a rule based on the concept of effective primary stress Psub(eff). The effective primary stress is a fictitious primary stress giving the same effects that the real loading (it is to say the same effect that the combination of an applied primary stress P and a cyclic straining). Determination of an upper bound value of Psub(eff) is made with the help of an efficiency diagram. More precisely the efficiency diagram include a curve giving a conservative value of an efficiency index V=P/Psub(eff) as a function of the secondary quotient SQ=ΔQ/P. Finally limitation of Psub(eff) intensity is discussed in regard with the current practice [fr

  12. Does global progress on sanitation really lag behind water? An analysis of global progress on community- and household-level access to safe water and sanitation.

    Science.gov (United States)

    Cumming, Oliver; Elliott, Mark; Overbo, Alycia; Bartram, Jamie

    2014-01-01

    Safe drinking water and sanitation are important determinants of human health and wellbeing and have recently been declared human rights by the international community. Increased access to both were included in the Millennium Development Goals under a single dedicated target for 2015. This target was reached in 2010 for water but sanitation will fall short; however, there is an important difference in the benchmarks used for assessing global access. For drinking water the benchmark is community-level access whilst for sanitation it is household-level access, so a pit latrine shared between households does not count toward the Millennium Development Goal (MDG) target. We estimated global progress for water and sanitation under two scenarios: with equivalent household- and community-level benchmarks. Our results demonstrate that the "sanitation deficit" is apparent only when household-level sanitation access is contrasted with community-level water access. When equivalent benchmarks are used for water and sanitation, the global deficit is as great for water as it is for sanitation, and sanitation progress in the MDG-period (1990-2015) outstrips that in water. As both drinking water and sanitation access yield greater benefits at the household-level than at the community-level, we conclude that any post-2015 goals should consider a household-level benchmark for both.

  13. Does global progress on sanitation really lag behind water? An analysis of global progress on community- and household-level access to safe water and sanitation.

    Directory of Open Access Journals (Sweden)

    Oliver Cumming

    Full Text Available Safe drinking water and sanitation are important determinants of human health and wellbeing and have recently been declared human rights by the international community. Increased access to both were included in the Millennium Development Goals under a single dedicated target for 2015. This target was reached in 2010 for water but sanitation will fall short; however, there is an important difference in the benchmarks used for assessing global access. For drinking water the benchmark is community-level access whilst for sanitation it is household-level access, so a pit latrine shared between households does not count toward the Millennium Development Goal (MDG target. We estimated global progress for water and sanitation under two scenarios: with equivalent household- and community-level benchmarks. Our results demonstrate that the "sanitation deficit" is apparent only when household-level sanitation access is contrasted with community-level water access. When equivalent benchmarks are used for water and sanitation, the global deficit is as great for water as it is for sanitation, and sanitation progress in the MDG-period (1990-2015 outstrips that in water. As both drinking water and sanitation access yield greater benefits at the household-level than at the community-level, we conclude that any post-2015 goals should consider a household-level benchmark for both.

  14. Long-term outcomes of penetrating keratoplasty in keratoconus:analysis of the factors associated with final visual acuities

    Directory of Open Access Journals (Sweden)

    Jin A Choi

    2014-06-01

    Full Text Available AIM: To investigate the long-term results of penetrating keratoplasty (PK in patients with keratoconus (KC and to evaluate factors that might influence the final visual outcome.METHODS:We retrospectively reviewed the data of all patients with clinical KC who had undergone PK by a single corneal surgeon in a single center from May 1980 to December 2005. The age of the patients, preoperative best-corrected visual acuity (BCVA, corneal thickness, death to preservation time, and preservation to transplantation time were recorded. Additionally, postoperative complications such as graft rejection, development of glaucoma and specular microscopy were checked during the follow-up.RESULTS:Sixty-nine eyes from 69 patients were finally included. The follow-up period was 8.64±6.13y. Graft rejection occurred in 4 eyes of 69 cases (5.8%, and the time to graft rejection was 2.1±1.3y. A Kaplan–Meier survival analysis showed that the estimated cumulative probability of graft rejection at 6, 13, and 17y after PK were 95.6%, 90.0%, and 78.8%, respectively. When we evaluated factors that might influence final BCVA in eyes, no disparity donor-host trephine size (same graft size as well as higher spherical equivalent, and average K-value were associated with higher final BCVA. (P=0.006, 0.051, 0.092, and 0.021 in eyes with follow-up <8y; P=0.068, 0.065, and 0.030 in eyes with follow-up ≥8y, respectively.CONCLUSION: The long-term results of PK in patients with KC were favorable with a high percentage of good BCVA. Less myopic change and low average K-reading, as well as a surgical technique using the same size donor-recipient button may provide better visual outcomes particularly in patients with KC.

  15. Nuclear and radiochemical techniques in chemical analysis. Progress report, August 1, 1978-July 31, 1979

    International Nuclear Information System (INIS)

    Finston, H.L.; Williams, E.T.

    1979-07-01

    Studies of homogeneous liquid-liquid extraction have been extended to include (1) a detailed determination of the phase diagram of the system propylene carbonate-water, (2) the extraction of a large variety of both monodentate and bidentate iron complexes, (3) the solvent extraction characteristics of analogues of propylene carbonate, (4) the behavior under pressure of the propylene carbonate water system, and (5) the extraction behavior of alkaline earth - TTA chelates. One consequence of these studies was the observation that the addition of ethanol to propylene carbonate-water or to isobutylene carbonate-water yields a single homogeneous phase. Subsequent evaporation of the ethanol restores the two immiscible phases. Past neutron activation analysis has been attempted for the heavy elements Pb, Bi, Tl at the Brookhaven HFBR (in- or near-core position) and at the Brookhaven CLIF facility. The latter appears more promising and we have initiated a collaborative program to use the CLIF facility. A milking system which can provide ca. 16 μCi of carrier-free 212 Pb was developed for use in an isotope dilution technique for lead. Collaboration with laboratories already determining trace lead by flameless Atomic Absorption or by concentration by electrodeposition into a hanging drop followed by Anodic stripping will be proposed. The Proton X-Ray Emission system has undergone marked improvement with the acquisition of a new high resolution Si(Li) detector and a new multi-channel analyzer system. Various techniques have been explored to dissolve and prepare samples for PIXE analysis and also for verification by Atomic Absorption analysis

  16. Nuclear and radiochemical techniques in chemical analysis. Progress report, August 1, 1978-July 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Finston, H. L.; Williams, E. T.

    1979-07-01

    Studies of homogeneous liquid-liquid extraction have been extended to include (1) a detailed determination of the phase diagram of the system propylene carbonate-water, (2) the extraction of a large variety of both monodentate and bidentate iron complexes, (3) the solvent extraction characteristics of analogues of propylene carbonate, (4) the behavior under pressure of the propylene carbonate water system, and (5) the extraction behavior of alkaline earth - TTA chelates. One consequence of these studies was the observation that the addition of ethanol to propylene carbonate-water or to isobutylene carbonate-water yields a single homogeneous phase. Subsequent evaporation of the ethanol restores the two immiscible phases. Past neutron activation analysis has been attempted for the heavy elements Pb, Bi, Tl at the Brookhaven HFBR (in- or near-core position) and at the Brookhaven CLIF facility. The latter appears more promising and we have initiated a collaborative program to use the CLIF facility. A milking system which can provide ca. 16 ..mu..Ci of carrier-free /sup 212/Pb was developed for use in an isotope dilution technique for lead. Collaboration with laboratories already determining trace lead by flameless Atomic Absorption or by concentration by electrodeposition into a hanging drop followed by Anodic stripping will be proposed. The Proton X-Ray Emission system has undergone marked improvement with the acquisition of a new high resolution Si(Li) detector and a new multi-channel analyzer system. Various techniques have been explored to dissolve and prepare samples for PIXE analysis and also for verification by Atomic Absorption analysis.

  17. A genetic analysis of Adhl regulation. Progress report, June 1991--May 1993

    Energy Technology Data Exchange (ETDEWEB)

    Freeling, M.

    1992-12-01

    Several separate but related studies are reported on the mechanism of alcohol dehydrogenase (Adh-1) are reported. A study of a deletion mutation in the TATA box region which resulted in an increase from 6--60% of wildtype Adh-1 expression in the revertant has led to a focus on trans-acting protein factors that bind the TATA box. Analysis of another revertant has led to study of cis-acting sequences in Adh-1 expression. Screening efforts aimed at defining different mutants affecting Adh-1 expression are reported.

  18. Research in progress in applied mathematics, numerical analysis, fluid mechanics, and computer science

    Science.gov (United States)

    1994-01-01

    This report summarizes research conducted at the Institute for Computer Applications in Science and Engineering in applied mathematics, fluid mechanics, and computer science during the period October 1, 1993 through March 31, 1994. The major categories of the current ICASE research program are: (1) applied and numerical mathematics, including numerical analysis and algorithm development; (2) theoretical and computational research in fluid mechanics in selected areas of interest to LaRC, including acoustics and combustion; (3) experimental research in transition and turbulence and aerodynamics involving LaRC facilities and scientists; and (4) computer science.

  19. 1988 Progress report of the EDF department for the analysis of experimental data and measurements

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    The 1988 activity report of the department for the analysis of experimental data and measurements (Department of Retour d'Experience Mesures-Essais, of EDF, France), is presented. The mission of the department is to collect and investigate data from the nuclear power plant operations. The investigations started before 1988, were carried on in 1988. The department main activities are: technology and information transfer from experimental activities, the construction of a standard data acquisition and processing system, the actions involving the N4 turbine, and the modelling and construction of new non-destructive methods of control. The most important facts and activities carried out in 1988 are presented [fr

  20. Analysis of Chinook Salmon in the Columbia River from an Ecosystem Perspective. Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Lichatowich, James A.; Mobrand, Lars E.

    1995-01-01

    Ecosystem Diagnosis and Treatment (EDT) methodology was applied to the analysis of chinook salmon in the mid-Columbia subbasins which flow through the steppe and steppe-shrub vegetation zones. The EDT examines historical changes in life history diversity related to changes in habitat. The emphasis on life history, habitat and historical context is consistent with and ecosystem perspective. This study is based on the working hypothesis that the decline in chinook salmon was at least in part due to a loss of biodiversity defined as the intrapopulation life history diversity. The mid Columbia subbasins included in the study are the Deschutes, John Day, Umatilla, Tucannon and Yakima.

  1. Performance Evaluation of Multivariate Analysis Methods on the $Z \\gamma$ Final State

    CERN Document Server

    Amos, Kieran Robert

    2017-01-01

    The performance of various machine learning algorithms are evaluated for their separation power of the $Z\\gamma$ Electroweak process (with $Z\\rightarrow\\ell\\ell$ and $\\ell=e,\\mu$) against the various backgrounds that populate the selection.\\\\ The Boosted Decision Tree method is found to deliver the best performance and is compared to that of neural net analysis and previously used methods using $36.1\\, \\text{fb}^{-1}$ of data obtained at $\\sqrt{s}=13\\, \\text{TeV}$ from the ATLAS detector in 2015 and 2016.

  2. Progress on RMC: a Monte Carlo neutron transport code for reactor analysis

    International Nuclear Information System (INIS)

    Wang, Kan; Li, Zeguang; She, Ding; Liu, Yuxuan; Xu, Qi; Shen, Huayun; Yu, Ganglin

    2011-01-01

    This paper presents a new 3-D Monte Carlo neutron transport code named RMC (Reactor Monte Carlo code), specifically intended for reactor physics analysis. This code is being developed by Department of Engineering Physics in Tsinghua University and written in C++ and Fortran 90 language with the latest version of RMC 2.5.0. The RMC code uses the method known as the delta-tracking method to simulate neutron transport, the advantages of which include fast simulation in complex geometries and relatively simple handling of complicated geometrical objects. Some other techniques such as computational-expense oriented method and hash-table method have been developed and implemented in RMC to speedup the calculation. To meet the requirements of reactor analysis, the RMC code has the calculational functions including criticality calculation, burnup calculation and also kinetics simulation. In this paper, comparison calculations of criticality problems, burnup problems and transient problems are carried out using RMC code and other Monte Carlo codes, and the results show that RMC performs quite well in these kinds of problems. Based on MPI, RMC succeeds in parallel computation and represents a high speed-up. This code is still under intensive development and the further work directions are mentioned at the end of this paper. (author)

  3. Organic Tanks Safety Program: Advanced organic analysis FY 1996 progress report

    International Nuclear Information System (INIS)

    1996-09-01

    Major focus during the first part of FY96 was to evaluate using organic functional group concentrations to screen for energetics. Fourier transform infrared and Raman spectroscopy would be useful screening tools for determining C-H and COO- organic content in tank wastes analyzed in a hot cell. These techniques would be used for identifying tanks of potential safety concern that may require further analysis. Samples from Tanks 241-C-106 and -C-204 were analyzed; the major organic in C-106 was B2EHPA and in C-204 was TBP. Analyses of simulated wastes were also performed for the Waste Aging Studies Task; organics formed as a result of degradation were identified, and the original starting components were monitored quantitatively. Sample analysis is not routine and required considerable methods adaptation and optimization. Several techniques have been evaluated for directly analyzing chelator and chelator fragments in tank wastes: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography with ultraviolet detection using Cu complexation. Although not directly funded by the Tanks Safety Program, the success of these techniques have implications for both the Flammable Gas and Organic Tanks Safety Programs

  4. Core melt progression and consequence analysis methodology development in support of the Savannah River Reactor PSA

    International Nuclear Information System (INIS)

    O'Kula, K.R.; Sharp, D.A.; Amos, C.N.; Wagner, K.C.; Bradley, D.R.

    1992-01-01

    A three-level Probabilistic Safety Assessment (PSA) of production reactor operation has been underway since 1985 at the US Department of Energy's Savannah River Site (SRS). The goals of this analysis are to: Analyze existing margins of safety provided by the heavy-water reactor (HWR) design challenged by postulated severe accidents; Compare measures of risk to the general public and onsite workers to guideline values, as well as to those posed by commercial reactor operation; and Develop the methodology and database necessary to prioritize improvements to engineering safety systems and components, operator training, and engineering projects that contribute significantly to improving plant safety. PSA technical staff from the Westinghouse Savannah River Company (WSRC) and Science Applications International Corporation (SAIC) have performed the assessment despite two obstacles: A variable baseline plant configuration and power level; and a lack of technically applicable code methodology to model the SRS reactor conditions. This paper discusses the detailed effort necessary to modify the requisite codes before accident analysis insights for the risk assessment were obtained

  5. Final Report: Sublinear Algorithms for In-situ and In-transit Data Analysis at Exascale.

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, Janine Camille [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Pinar, Ali [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Seshadhri, C. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Thompson, David [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Salloum, Maher [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Bhagatwala, Ankit [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Chen, Jacqueline H. [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2015-09-01

    Post-Moore's law scaling is creating a disruptive shift in simulation workflows, as saving the entirety of raw data to persistent storage becomes expensive. We are moving away from a post-process centric data analysis paradigm towards a concurrent analysis framework, in which raw simulation data is processed as it is computed. Algorithms must adapt to machines with extreme concurrency, low communication bandwidth, and high memory latency, while operating within the time constraints prescribed by the simulation. Furthermore, in- put parameters are often data dependent and cannot always be prescribed. The study of sublinear algorithms is a recent development in theoretical computer science and discrete mathematics that has significant potential to provide solutions for these challenges. The approaches of sublinear algorithms address the fundamental mathematical problem of understanding global features of a data set using limited resources. These theoretical ideas align with practical challenges of in-situ and in-transit computation where vast amounts of data must be processed under severe communication and memory constraints. This report details key advancements made in applying sublinear algorithms in-situ to identify features of interest and to enable adaptive workflows over the course of a three year LDRD. Prior to this LDRD, there was no precedent in applying sublinear techniques to large-scale, physics based simulations. This project has definitively demonstrated their efficacy at mitigating high performance computing challenges and highlighted the rich potential for follow-on re- search opportunities in this space.

  6. Tools for Accurate and Efficient Analysis of Complex Evolutionary Mechanisms in Microbial Genomes. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Nakhleh, Luay

    2014-03-12

    I proposed to develop computationally efficient tools for accurate detection and reconstruction of microbes' complex evolutionary mechanisms, thus enabling rapid and accurate annotation, analysis and understanding of their genomes. To achieve this goal, I proposed to address three aspects. (1) Mathematical modeling. A major challenge facing the accurate detection of HGT is that of distinguishing between these two events on the one hand and other events that have similar "effects." I proposed to develop a novel mathematical approach for distinguishing among these events. Further, I proposed to develop a set of novel optimization criteria for the evolutionary analysis of microbial genomes in the presence of these complex evolutionary events. (2) Algorithm design. In this aspect of the project, I proposed to develop an array of e cient and accurate algorithms for analyzing microbial genomes based on the formulated optimization criteria. Further, I proposed to test the viability of the criteria and the accuracy of the algorithms in an experimental setting using both synthetic as well as biological data. (3) Software development. I proposed the nal outcome to be a suite of software tools which implements the mathematical models as well as the algorithms developed.

  7. Final safety analysis report for the Galileo Mission: Volume 1, Reference design document

    Energy Technology Data Exchange (ETDEWEB)

    1988-05-01

    The Galileo mission uses nuclear power sources called Radioisotope Thermoelectric Generators (RTGs) to provide the spacecraft's primary electrical power. Because these generators contain nuclear material, a Safety Analysis Report (SAR) is required. A preliminary SAR and an updated SAR were previously issued that provided an evolving status report on the safety analysis. As a result of the Challenger accident, the launch dates for both Galileo and Ulysses missions were later rescheduled for November 1989 and October 1990, respectively. The decision was made by agreement between the DOE and the NASA to have a revised safety evaluation and report (FSAR) prepared on the basis of these revised vehicle accidents and environments. The results of this latest revised safety evaluation are presented in this document (Galileo FSAR). Volume I, this document, provides the background design information required to understand the analyses presented in Volumes II and III. It contains descriptions of the RTGs, the Galileo spacecraft, the Space Shuttle, the Inertial Upper Stage (IUS), the trajectory and flight characteristics including flight contingency modes, and the launch site. There are two appendices in Volume I which provide detailed material properties for the RTG.

  8. Analysis of the premitting processes associated with exploration of Federal OCS leases. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-11-01

    Under contract to the Office of Leasing Policy Development (LPDO), Jack Faucett Associates is currently undertaking the description and analysis of the Outer Continental Shelf (OCS) regulatory process to determine the nature of time delays that affect OCS production of oil and gas. This report represents the results of the first phase of research under this contract, the description and analysis of regulatory activity associated with exploration activities on the Federal OCS. Volume 1 contains the following three sections: (1) study results; (2) Federal regulatory activities during exploration of Federal OCS leases which involved the US Geological Survey, Environmental Protection Agency, US Coast Guard, Corps of Engineers, and National Ocean and Atmospheric Administration; and (3) state regulatory activities during exploration of Federal OCS leases of Alaska, California, Louisiana, Massachusetts, New Jersey, North Carolina, and Texas. Volume II contains appendices of US Geological Survey, Environmental Protection Agency, Coast Guard, Corps of Engineers, the Coastal Zone Management Act, and Alaska. The major causes of delay in the regulatory process governing exploration was summarized in four broad categories: (1) the long and tedious process associated with the Environmental Protection Agency's implementation of the National Pollutant Discharge Elimination System Permit; (2) the lack of mandated time periods for the completion of individual activities in the permitting process; (3) the lack of overall coordination of OCS exploratory regulation; and (4) the inexperience of states, the Federal government and industry relating to the appropriate level of regulation for first-time lease sale areas.

  9. Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: A systematic review and meta-analysis

    NARCIS (Netherlands)

    Currie, G. (Gemma); Taylor, A.H.M. (Alison H. M.); Fujita, T. (Toshiro); Ohtsu, H. (Hiroshi); Lindhardt, M. (Morten); K. Rossing; Boesby, L. (Lene); Edwards, N.C. (Nicola C.); Ferro, C.J. (Charles J.); J. Townend (Jonathan); A.H. van den Meiracker (Anton); Saklayen, M.G. (Mohammad G.); Oveisi, S. (Sonia); Jardine, A.G. (Alan G.); C. Delles (Christian); Preiss, D.J. (David J.); Mark, P.B. (Patrick B.)

    2016-01-01

    textabstractBackground: Hypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment with renin angiotensin system inhibition, kidney function declines in many patients. Aldosterone excess is a risk factor for progression of kidney disease.

  10. HTGR accident initiation and progression analysis status report. Volume VIII. Responses to comments on AIPA status report

    Energy Technology Data Exchange (ETDEWEB)

    Raabe, P.H.

    1977-01-01

    The first seven volumes of the report series provide formal documentation of the status of the ERDA-sponsored Accident Initiation and Progression Analysis (AIPA) study as of the end of FY75. That portion of the report was given broad distribution to government agencies, industrial organizations, and academic institutions. Comments on the Status Report have been actively solicited from these and other organizations. The volume presented (the eighth in the AIPA Status Report) documents all of the formal written comments that have been received as of September 30, 1976, together with the responses to those comments. The comments as presented are direct quotations from the manuscripts as submitted by the reviewers; none have been paraphrased. The comments are presented in the same order as submitted by the reviewers and are generally addressed individually.

  11. Stochastic modelling of slow-progressing tumors: Analysis and applications to the cell interplay and control of low grade gliomas

    Science.gov (United States)

    Rodríguez, Clara Rojas; Fernández Calvo, Gabriel; Ramis-Conde, Ignacio; Belmonte-Beitia, Juan

    2017-08-01

    Tumor-normal cell interplay defines the course of a neoplastic malignancy. The outcome of this dual relation is the ultimate prevailing of one of the cells and the death or retreat of the other. In this paper we study the mathematical principles that underlay one important scenario: that of slow-progressing cancers. For this, we develop, within a stochastic framework, a mathematical model to account for tumor-normal cell interaction in such a clinically relevant situation and derive a number of deterministic approximations from the stochastic model. We consider in detail the existence and uniqueness of the solutions of the deterministic model and study the stability analysis. We then focus our model to the specific case of low grade gliomas, where we introduce an optimal control problem for different objective functionals under the administration of chemotherapy. We derive the conditions for which singular and bang-bang control exist and calculate the optimal control and states.

  12. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Yelton, John Martin [UF; Mitselmakher, Guenakh [UF; Korytov, Andrey [UF; Avery, Paul [UF; Furic, Ivan [UF; Acosta, Darin [UF; Konigsberg, Jacobo [UF; Field, Richard [UF; Matchev, Konstantin [UF; Ramond, Pierre [UF; Thorn, Richard [UF; Sikivie, Pierre [UF; Ray, Heather [UF; Tanner, David [UF

    2013-10-10

    We report on progress in a series of different directions within high energy physics research. 1. Neutrino research in hardware and software on the Minerva and MiniBooNE experiments 2. Experimental particle physics at the hadron colliders, with emphasis on research and development and data analysis on the CMS experiment operating at the CERN LHC. This includes research on the discovery and properties on the Higgs Boson. 3. Educational outreach through the Quarknet program, taking physics research into High School classrooms. 4. Theoretical and Phenomenological High Energy research, covering a broad range of activities ranging from fundamental theoretical issues to areas of immediate phenomenological importance. 5. Experiment searches for the Axion, as part of the ADMX experiment.

  13. Gap analysis between provisional diagnosis and final diagnosis in government and private teaching hospitals: A record-linked comparative study

    Directory of Open Access Journals (Sweden)

    Sudeshna Chatterjee

    2016-01-01

    Full Text Available Aims: 1. To identify the extent of clinical gaps at the context of knowledge, practice and systems. 2. To formulate necessary intervention measures towards bridging the gaps. Settings and Design: Comparative, cross-sectional and non-interventional study. Methods and Material: It is retrospective, record-based study conducted upon inpatients (n = 200 of major disciplines of two teaching hospitals. Major outcome variables were to observe the matching and un-matching of final and provisional diagnosis by using ICD-10 criteria. Statistical Analysis Used: Comparative analysis of specific and selective gaps were estimated in terms of percentage (%. Results: Pilot observation showed the existence of gaps between provisional and final diagnosis in both private and government institution. Both knowledge and skill gaps were evident in caregivers and gap in documentation was existent in medical records. Conclusions: The pilot data is may be an eye-opener to public and private governance systems for understanding and revising the process service planning and service delivery. Necessary intervention measures may be contemplated towards enhancing diagnostic skill of doctors for quality hospital care.

  14. Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives

    DEFF Research Database (Denmark)

    Ashley, Jon; Shahbazi, Mohammad-Ali; Kant, Krishna

    2017-01-01

    loading capacity. MIPs have been intensively employed in classical solid-phase extraction and solid-phase microextraction. More recently, MIPs have been combined with magnetic bead extraction, which greatly simplifies sample handling procedures. Studies have consistently shown that MIPs can effectively...... minimize complex food matrix effects, and improve recoveries and detection limits. In addition to sample preparation, MIPs have also been viewed as promising alternatives to bio-receptors due to the inherent molecular recognition abilities and the high stability in harsh chemical and physical conditions....... MIPs have been utilized as receptors in biosensing platforms such as electrochemical, optical and mass biosensors to detect various analytes in food. In this review, we will discuss the current state-of-the-art of MIP synthesis and applications in the context of food analysis. We will highlight...

  15. [Research progress and application prospect of near infrared spectroscopy in soil nutrition analysis].

    Science.gov (United States)

    Ding, Hai-quan; Lu, Qi-peng

    2012-01-01

    "Digital agriculture" or "precision agriculture" is an important direction of modern agriculture technique. It is the combination of the modern information technique and traditional agriculture and becomes a hotspot field in international agriculture research in recent years. As a nondestructive, real-time, effective and exact analysis technique, near infrared spectroscopy, by which precision agriculture could be carried out, has vast prospect in agrology and gradually gained the recognition. The present paper intends to review the basic theory of near infrared spectroscopy and its applications in the field of agrology, pointing out that the direction of NIR in agrology should based on portable NIR spectrograph in order to acquire qualitative or quantitative information from real-time measuring in field. In addition, NIRS could be combined with space remote sensing to macroscopically control the way crop is growing and the nutrition crops need, to change the current state of our country's agriculture radically.

  16. Tank 241-AZ-102 Privatization Push Mode Core Sampling and Analysis Plan; FINAL

    International Nuclear Information System (INIS)

    TEMPLETON, A.M.

    1999-01-01

    This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AZ-102. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AZ-102. Push mode core samples will be obtained from risers 15C and 24A to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples, composite the liquids and solids, perform chemical analyses, and provide subsamples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AZ-102 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plan

  17. Which territorial integration of participative renewable energies? Present status and analysis of French projects. Final report

    International Nuclear Information System (INIS)

    Devisse, Jean-Stephane; Gilbert, Olivier; Reix, Fabien; GASPARD, Albane

    2016-02-01

    This study aimed at qualifying actors involved in projects (stakeholders, motivations, who decides what and how), at identifying the available resources (technical and financial abilities, project management abilities), at describing the mobilisation work and territorial dialogue processes, and at exploring how benefit distribution contributes to territorial dynamics. This study first identified participative renewable energy projects in France. A survey by questionnaire was then performed among project holders. Six projects have also been more deeply studied (a mix of solar and photovoltaic and wind energy, two wind farms located in two different regions, a solar photovoltaic project, a hydroelectric project, and a project on biomass from forest). After the methodology, the report defines what a participative renewable energy project is, proposes an overview of these projects in 2015, present the case studies, and proposes an analysis on the different aspects of the project process

  18. Handbook of human-reliability analysis with emphasis on nuclear power plant applications. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Swain, A D; Guttmann, H E

    1983-08-01

    The primary purpose of the Handbook is to present methods, models, and estimated human error probabilities (HEPs) to enable qualified analysts to make quantitative or qualitative assessments of occurrences of human errors in nuclear power plants (NPPs) that affect the availability or operational reliability of engineered safety features and components. The Handbook is intended to provide much of the modeling and information necessary for the performance of human reliability analysis (HRA) as a part of probabilistic risk assessment (PRA) of NPPs. Although not a design guide, a second purpose of the Handbook is to enable the user to recognize error-likely equipment design, plant policies and practices, written procedures, and other human factors problems so that improvements can be considered. The Handbook provides the methodology to identify and quantify the potential for human error in NPP tasks.

  19. Economic analysis of wind-powered farmhouse and farm building heating systems. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Stafford, R.W.; Greeb, F.J.; Smith, M.F.; Des Chenes, C.; Weaver, N.L.

    1981-01-01

    The study evaluated the break-even values of wind energy for selected farmhouses and farm buildings focusing on the effects of thermal storage on the use of WECS production and value. Farmhouse structural models include three types derived from a national survey - an older, a more modern, and a passive solar structure. The eight farm building applications that were analyzed include: poultry-layers, poultry-brooding/layers, poultry-broilers, poultry-turkeys, swine-farrowing, swine-growing/finishing, dairy, and lambing. These farm buildings represent the spectrum of animal types, heating energy use, and major contributions to national agricultural economic values. All energy analyses were based on hour-by-hour computations which allowed for growth of animals, sensible and latent heat production, and ventilation requirements. Hourly or three-hourly weather data obtained from the National Climatic Center was used for the nine chosen analysis sites, located throughout the United States and corresponding to regional agricultural production centers.

  20. Waste Receiving and Processing (WRAP) Facility Final Safety Analysis Report (FSAR)

    Energy Technology Data Exchange (ETDEWEB)

    TOMASZEWSKI, T.A.

    2000-04-25

    The Waste Receiving and Processing Facility (WRAP), 2336W Building, on the Hanford Site is designed to receive, confirm, repackage, certify, treat, store, and ship contact-handled transuranic and low-level radioactive waste from past and present U.S. Department of Energy activities. The WRAP facility is comprised of three buildings: 2336W, the main processing facility (also referred to generically as WRAP); 2740W, an administrative support building; and 2620W, a maintenance support building. The support buildings are subject to the normal hazards associated with industrial buildings (no radiological materials are handled) and are not part of this analysis except as they are impacted by operations in the processing building, 2336W. WRAP is designed to provide safer, more efficient methods of handling the waste than currently exist on the Hanford Site and contributes to the achievement of as low as reasonably achievable goals for Hanford Site waste management.