WorldWideScience

Sample records for analog studies licensing

  1. The role of natural analogs in the repository licensing process

    International Nuclear Information System (INIS)

    Murphy, W.M.

    1995-01-01

    The concept of a permanent geologic repository for high-level nuclear waste (NLW) is implicitly based on analogy to natural systems that have been stable for millions or billions of years. The time of radioactive and chemical toxicity of HLW exceeds the duration of human civilization, and it is impossible to demonstrate the accuracy of predictions of the behavior of engineered or social systems over such long periods

  2. Natural Analog Studies at Pena Blanca, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    A.M. Simmons

    2005-07-11

    The significance of the Pena Blanca uranium deposits in the State of Chihuahua, Mexico as potential natural analogs for a nuclear waste repository in unsaturated welded tuff was first recognized in the 1980s. In the 1970s, the Pena Blanca region was a major target of uranium exploration and exploitation by the Mexican government. Since then the Nopal I uranium deposit has been studied extensively by researchers in the U.S., Mexico, and Europe. The Nopal I deposit represents an environment similar to that of the proposed high-level radioactive waste repository at Yucca Mountain in many ways. Both are located in semi-arid regions. Both are located in Tertiary rhyolitic tuffs overlying carbonate rocks that have been subjected to basin and range-style tectonic deformation. Both are located in a chemically oxidizing, unsaturated zone 200 m or more above the water table. The alteration of uraninite to secondary minerals at Nopal I may be similar to the alteration of uranium fuel rods in this type of setting. Investigations at Nopal I and in the surrounding Sierra Pena Blanca have included detailed outcrop mapping, hydrologic and isotopic studies of flow and transport, studies of mineral alteration, modeling, and performance assessment.

  3. Materials licensing study, Phase 1. Volume 2. Findings and recommendations

    International Nuclear Information System (INIS)

    Elliot, J.M.; Arcuni, A.A.; Immerman, W.H.; Welles, B.W.; Varnado, G.B.

    1983-11-01

    This is one of a series of seven reports which describe a study of nuclear material licensing conducted for the Office of Nuclear Regulatory Material Safety and Safeguards, US Nuclear Regulatory Commission (NRC). The purposes of this project are to analyze the process used by NRC to license nuclear materials, and based upon this analysis to recommend measures to improve the efficiency of such license application review. This report presents summary findings and recommendations relevant to the data collection effort documented in SAND83-7081/1 of 3. Recommendations are based upon findings derived from review of deficiency letters, dockets, application guides, the license application review process, and the license renewal process. Several of the eleven (11) recommendations address the need for an improved regulatory base which would integrate and streamline all the diverse regulatory documents and procedures. In addition, the report proposes implementation of a computer based nuclear materials licensing support system to aid in all phases of materials license review

  4. Developing Fluorescent Hyaluronan Analogs for Hyaluronan Studies

    Directory of Open Access Journals (Sweden)

    Shi Ke

    2012-02-01

    Full Text Available Two kinds of fluorescent hyaluronan (HA analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR dye. At low labeling ratios, the hyaluronan uptake can be directly imaged while at high labeling ratios, the fluorescent signal is quenched and signal generation occurs only after degradation. It is found that the conjugate containing 1%–2% NIR dye can be used as a normal optical imaging agent, while bioactivable imaging agents are formed at 6% to 17% dye loading. It was determined that the conjugation of dye to HA with different loading percentages does not impact HA biodegradation by hyaluronidase (Hyal. The feasibility of using these two NIR fluorescent hyaluronan analogs for HA investigation was evaluated in vivo with optical imaging. The data demonstrates that the 1% dye loaded fluorescent HA can be used to monitor the behavior of HA and its fragments, whereas bioactivatable HA imaging agent (17% dye in HA is more suitable for detecting HA fragments.

  5. Cystic Fibrosis Patents: A Case Study of Successful Licensing.

    Science.gov (United States)

    Minear, Mollie A; Kapustij, Cristina; Boden, Kaeleen; Chandrasekharan, Subhashini; Cook-Deegan, Robert

    2013-03-01

    From 2006-2010, Duke University's Center for Public Genomics prepared eight case studies examining the effects of gene patent licensing practices on clinical access to genetic testing for ten clinical conditions. One of these case studies focused on the successful licensing practices employed by the University of Michigan and the Hospital for Sick Children in Toronto for patents covering the CFTR gene and its ΔF508 mutation that causes a majority of cystic fibrosis cases. Since the licensing of these patents has not impeded clinical access to genetic testing, we sought to understand how this successful licensing model was developed and whether it might be applicable to other gene patents. We interviewed four key players who either were involved in the initial discussions regarding the structure of licensing or who have recently managed the licenses and collected related documents. Important features of the licensing planning process included thoughtful consideration of potential uses of the patent; anticipation of future scientific discoveries and technological advances; engagement of relevant stakeholders, including the Cystic Fibrosis Foundation; and using separate licenses for in-house diagnostics versus kit manufacture. These features led to the development of a licensing model that has not only allowed the patent holders to avoid the controversy that has plagued other gene patents, but has also allowed research, development of new therapeutics, and wide-spread dissemination of genetic testing for cystic fibrosis. Although this licensing model may not be applicable to all gene patents, it serves as a model in which gene patent licensing can successfully enable innovation, investment in therapeutics research, and protect intellectual property while respecting the needs of patients, scientists, and public health.

  6. Changing mobility patterns and road mortality among pre-license teens in a late licensing country : an epidemiological study.

    NARCIS (Netherlands)

    Twisk, D.A.M. Bos, N.M. Shope, J.T. & Kok, G.

    2013-01-01

    Whereas the safety of teens in early licensing countries has been extensively studied, little is known about the safety of pre-license teens in late licensing countries, where these teens also may be at risk. This risk exists because of the combination of a) increasing use of travel modes with a

  7. Analogous study of English linguistic knowledge between ...

    African Journals Online (AJOL)

    Marketing strategy is the effective deployment and coordination of marketing resources to achieved the business enterprise objectives within a particular product market. However, banks often have problem of formulating good marketing strategy plan that will enhance the bank general performance. The study examine ...

  8. Application of natural analog studies to exploration for ore deposits

    International Nuclear Information System (INIS)

    Gustafson, D.L.

    1995-01-01

    Natural analogs are viewed as similarities in nature and are routinely utilized by exploration geologists in their search for economic mineral deposits. Ore deposit modeling is undertaken by geologists to direct their exploration activities toward favorable geologic environments and, therefore, successful programs. Two types of modeling are presented: (i) empirical model development based on the study of known ore deposit characteristics, and (ii) concept model development based on theoretical considerations and field observations that suggest a new deposit type, not known to exist in nature, may exist and justifies an exploration program. Key elements that are important in empirical model development are described, and examples of successful applications of these natural analogs to exploration are presented. A classical example of successful concept model development, the discovery of the McLaughlin gold mine in California, is presented. The utilization of natural analogs is an important facet of mineral exploration. Natural analogs guide explorationists in their search for new discoveries, increase the probability of success, and may decrease overall exploration expenditure

  9. The Implementation of Integrated One-Stop Service at Licensing Service Agency in Order to Improve Licensing Service to Society (Case Study on Business License Service at Investment and Integrated Licensing Service Agency (IILSA) of Pasuruan City)

    OpenAIRE

    Pramita, Priyani Dini; Rochmah, Siti; Nur Pratiwi, Ratih

    2014-01-01

    This study discusses about the implementation of integrated one-stop licensing services related to service of SIUP, conducted by the Investment and Integrated Licensing Service Agency (IILSA) in Pasuruan City. In general there are any issues related to License for business activities, namely: the complicated procedures, high costs and legal uncertainty. To overcome this problem the government issued Permendagri number 24 of 2006 about Guidelines for the Implementation of One Stop Services. Th...

  10. Are study strategies related to medical licensing exam performance?

    Science.gov (United States)

    West, Courtney; Kurz, Terri; Smith, Sherry; Graham, Lori

    2014-11-02

    To examine the relationship between study strategies and performance on a high stakes medical licensing exam entitled the United States Medical Licensing Examination Step 1. The action research project included seventy nine student participants at the Texas A & M Health Science Center College of Medicine during their pre-clinical education. Data collection included pre-matriculation and matriculation academic performance data, standardized exam data, and the Learning and Study Strategies Instrument. Multiple regression analyses were conducted. For both models, the dependent variable was the Step 1 score, and the independent variables included Medical College Admission Test, Undergraduate Grade Point Average, Year 1 Average, Year 2 Average, Customized National Board of Medical Examiners Average, Comprehensive Basic Science Exam score, and Learning and Study Strategy Instrument sub-scores. Model 2 added Comprehensive Basic Science Self-Assessment average. Concentration (Model 1 - β = .264; Model 2 - β = .254) was the only study strategy correlated with Step 1 performance. The other statistically significant predictors were Customized National Board of Medical Examiners Average (β = .315) and Year 2 Average (β = .280) in Model 1 and Comprehensive Basic Science Self-Assessment Average (β = .338) in Model 2. There does appear to be a relationship between the study strategy concentration and Step 1 licensing exam performance. Teaching students to practice and utilize certain techniques to improve concentration skills when preparing for and taking exams may help improve licensing exam scores.

  11. Precipitation forecasting through an analog sorting technique: a comparative study

    Science.gov (United States)

    Ben Daoud, A.; Sauquet, E.; Lang, M.; Bontron, G.; Obled, C.

    2011-04-01

    This study aims at comparing two quantitative precipitation forecasting techniques based on the meteorological analogy concept. Method A considers first a selection of analogous situations at synoptic scale. Second a subset of the most similar situations in terms of hygrometry is extracted. Method B extends method A by two innovative ways, which are restricting the search for analogues with temperature information instead of the common season criterion, and exploiting the information about vertical motion considering vertical velocity. Forecasts are evaluated in a perfect prognosis context and in operational conditions as well, by mean of verification measures (Continuous Ranked Probability Skill Score and scores computed from contingency tables). Results of the case study in France show that: (1) there is an increase in forecast skill when temperature and vertical velocity are included in the procedure, (2) it is possible to anticipate rainfall events up to one week ahead and (3) the introduction of new variables such as vertical velocity may be useless beyond few days ahead if the forecast of the weather model is not reliable.

  12. Reasoning by analogy: rational foundation of natural analogue studies

    International Nuclear Information System (INIS)

    Petit, J.-C.

    1992-01-01

    Long-term extrapolations concerning the safety of a nuclear waste repository cannot be satisfactorily made on the sole basis of short-term laboratory investigations. Most nuclear countries have hence developed an approach relying on the following research directions: 1. laboratory experiments; 2. in situ testing; 3. modeling; and 4. natural analogues, which are the only means by which very slow mechanisms can be identified and by which long-term predictions of models can be tested for pertinence (if not truly validated). Although the field of natural analogues has grown very rapidly in recent years, receiving support from varied specialists and institutions involved in radioactive waste disposal, there is not yet a full consensus on their actual usefulness. More problematic is the criticism sometimes made that analogical reasoning is not ''true science'' and that information retrieved from the study of natural analogues will always remain questionable. The present paper gives some clues about the exact status of reasoning by analogy, compared to more ''scientific'' ways of deriving information from investigated systems. It is not a thorough discussion of this very complex, and by far too philosophical issue but we hope, at least, to present to readers of papers devoted to natural analogue studies arguments showing that this approach has some sound foundation. (author)

  13. Licensing method for new nuclear power plant: A study on decision making modeling

    Energy Technology Data Exchange (ETDEWEB)

    Ramli, N; Ohaga, E. O.; Jung, J. C. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2012-10-15

    This work provides a study on decision making modeling for a licensing method of a new nuclear power plant. SWOT analysis provides the licensing alternatives attributes, then the expectation from either COL or two step licensing method is decided by inputting the output from the Hurwitz mathematical model. From the analysis, COL shows the best candidate for both optimistic and pessimistic conditions.

  14. Licensing method for new nuclear power plant: A study on decision making modeling

    International Nuclear Information System (INIS)

    Ramli, N; Ohaga, E. O.; Jung, J. C.

    2012-01-01

    This work provides a study on decision making modeling for a licensing method of a new nuclear power plant. SWOT analysis provides the licensing alternatives attributes, then the expectation from either COL or two step licensing method is decided by inputting the output from the Hurwitz mathematical model. From the analysis, COL shows the best candidate for both optimistic and pessimistic conditions

  15. Changing mobility patterns and road mortality among pre-license teens in a late licensing country: an epidemiological study.

    Science.gov (United States)

    Twisk, Divera; Bos, Niels; Shope, Jean T; Kok, Gerjo

    2013-04-11

    Whereas the safety of teens in early licensing countries has been extensively studied, little is known about the safety of pre-license teens in late licensing countries, where these teens also may be at risk. This risk exists because of the combination of a) increasing use of travel modes with a high injury risk, such as bicycles and mopeds, b) inexperience, and c) teens' developmental stage, known to be associated with risk taking and novelty seeking, especially among males. To explore the magnitude and nature of pre-license road risk, this study analysed epidemiological data from the Netherlands, and hypothesized that in this late licensing country, 'independent travel' and the use of riskier modes of transport increase among pre-license teens 10 to 17 years of age, resulting in higher fatality rates, with 'experience' and 'gender' as risk modifying factors. National travel and fatality data of pre-license adolescents in the Netherlands were analysed by traffic role (cyclist, pedestrian, car passenger and moped rider), and compared to a younger age group (0-9 years) and an older age group (18+ years). The study of travel data showed that teens migrate from being car occupants to being users of riskier modes of transport, specifically bicycles and mopeds. This migration resulted in a strong rise in road fatalities, illustrating the importance of mobility patterns for understanding changes in road fatalities in this age group. The data further suggested a protective role of early cycle experience for young adolescent cyclists, particularly for young males. But further study into the underlying mechanism is needed to confirm this relationship. Moped risk was extremely high, especially among young males, and even higher than that of young male car drivers. The study confirmed the importance of changes in mobility patterns for understanding the rising road mortality when youngsters enter into their teens. The focus on fatalities has led to an underestimation of the

  16. Rheology of lava flows on Mercury: An analog experimental study

    Science.gov (United States)

    Sehlke, A.; Whittington, A. G.

    2015-11-01

    We experimentally determined the rheological evolution of three basaltic analog compositions appropriate to Mercury's surface, during cooling, and crystallization. Investigated compositions are an enstatite basalt, and two magnesian basalts representing the compositional end-members of the northern volcanic plains with 0.19 wt % (NVP) and 6.26 wt % Na2O (NVP-Na). The viscosity-strain rate dependence of lava was quantified using concentric cylinder viscometry. We measured the viscosities of the crystal-free liquids from 1600°C down to the first detection of crystals. Liquidus temperatures of the three compositions studied are around 1360°C, and all three compositions are more viscous than Hawaiian basalt at the same temperature. The onset of pseudoplastic behavior was observed at crystal fractions ~0.05 to 0.10, which is consistent with previous studies on mafic lavas. We show that all lavas develop detectable yield strengths at crystal fractions around 0.20, beyond which the two-phase suspensions are better described as Herschel-Bulkley fluids. By analogy with the viscosity-strain rate conditions at which the pahoehoe to `a`a transition occurs in Kilauea basalt, this transition is predicted to occur at ~1260 ± 10°C for the enstatite basalt, at ~1285 ± 20°C for the NVP, and at ~1240 ± 40°C for the NVP-Na lavas. Our results indicate that Mercury lavas are broadly similar to terrestrial ones, which suggests that the extensive smooth lava plains of Mercury could be due to large effusion rates (flood basalts) and not to unusually fluid lavas.

  17. Feasibility Study of a Lunar Analog Bed Rest Model

    Science.gov (United States)

    Cromwell, Ronita L.; Platts, Steven H.; Yarbough, Patrice; Buccello-Stout, Regina

    2010-01-01

    The purpose of this study was to determine the feasibility of using a 9.5deg head-up tilt bed rest model to simulate the effects of the 1/6 g load to the human body that exists on the lunar surface. The lunar analog bed rest model utilized a modified hospital bed. The modifications included mounting the mattress on a sled that rolled on bearings to provide freedom of movement. The weight of the sled was off-loaded using a counterweight system to insure that 1/6 body weight was applied along the long axis (z-axis) of the body. Force was verified through use of a force plate mounted at the foot of the bed. A seating assembly was added to the bed to permit periods of sitting. Subjects alternated between standing and sitting positions throughout the day. A total of 35% of the day was spent in the standing position and 65% was spent sitting. In an effort to achieve physiologic fluid shifts expected for a 1/6 G environment, subjects wore compression stockings and performed unloaded foot and ankle exercises. Eight subjects (3 females and 5 males) participated in this study. Subjects spent 13 days in the pre-bed rest phase, 6 days in bed rest and 3 days post bed rest. Subjects consumed a standardized diet throughout the study. To determine feasibility, measures of subject comfort, force and plasma volume were collected. Subject comfort was assessed using a Likert scale. Subjects were asked to assess level of comfort (0-100) for 11 body regions and provide an overall rating. Results indicated minimal to no discomfort as most subjects reported scores of zero. Force measures were performed for each standing position and were validated against subject s calculated 1/6 body weight (r(sup 2) = 0.993). The carbon monoxide rebreathing technique was used to assess plasma volume during pre-bed rest and on the last day of bed rest. Plasma volume results indicated a significant decrease (p = 0.001) from pre to post bed rest values. Subjects lost on average 8.3% (sd = 6.1%) during the

  18. Commercial driver's license (CDL) workflow study : final report.

    Science.gov (United States)

    2016-03-01

    Kentucky uses federally funded, time-limited (FFTL) employees to handle some of the administrative work necessary to : meet federal compliance standards for commercial drivers licenses (CDLs). The Federal Motor Carrier Safety : Administration (FMC...

  19. Methodology for the digital calibration of analog circuits and systems with case studies

    CERN Document Server

    Pastre, Marc

    2006-01-01

    Methodology for the Digital Calibration of Analog Circuits and Systems shows how to relax the extreme design constraints in analog circuits, allowing the realization of high-precision systems even with low-performance components. A complete methodology is proposed, and three applications are detailed. To start with, an in-depth analysis of existing compensation techniques for analog circuit imperfections is carried out. The M/2+M sub-binary digital-to-analog converter is thoroughly studied, and the use of this very low-area circuit in conjunction with a successive approximations algorithm for digital compensation is described. A complete methodology based on this compensation circuit and algorithm is then proposed. The detection and correction of analog circuit imperfections is studied, and a simulation tool allowing the transparent simulation of analog circuits with automatic compensation blocks is introduced. The first application shows how the sub-binary M/2+M structure can be employed as a conventional di...

  20. Potential threat to licensed nuclear activities from insiders (insider study). Technical report

    International Nuclear Information System (INIS)

    Mullen, S.A.; Davidson, J.J.; Jones, H.B. Jr.

    1980-07-01

    The Insider Study was undertaken by NRC staff at the request of the Commission. Its objectives were to: (1) determine the characteristics of potential insider adversaries to licensed nuclear activities; (2) examine security system vulnerabilities to insider adversaries; and (3) assess the effectiveness of techniques used to detect or prevent insider malevolence. The study analyzes insider characteristics as revealed in incidents of theft or sabotage that occurred in the nuclear industry, analogous industries, government agencies, and the military. Adversary characteristics are grouped into four categories: position-related, behavioral, resource and operational. It also analyzes (1) the five security vulnerabilities that most frequently accounted for the success of the insider crimes in the data base; (2) the 11 means by which insider crimes were most often detected; and (3) four major and six lesser methods aimed at preventing insider malevolence. In addition to case history information, the study contains data derived from non-NRC studies and from interviews with over 100 security experts in industry, government (federal and state), and law enforcement

  1. An In Situ Study of Analogical Reasoning in Novice and Experienced Design Engineers

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Christensen, B T

    2009-01-01

    This paper describes a study to understand the use of analogies by design engineers with different levels of experience in an adaptive design domain. Protocol analyses of 12 design engineers have been analyzed to understand the functions and reasoning of the analogies. The protocols are real......-world data from the aerospace industry. The findings indicate a significant difference in both the use of analogies by novices and experienced designers and the reasoning from the analogies. Novices were found to predominantly transfer information related to the geometric properties without explicit...

  2. Embedding Analogical Reasoning into 5E Learning Model: A Study of the Solar System

    Science.gov (United States)

    Devecioglu-Kaymakci, Yasemin

    2016-01-01

    The purpose of this study was to investigate how the 5E learning model affects learning about the Solar System when an analogical model is utilized in teaching. The data were gathered in an urban middle school 7th grade science course while teaching relevant astronomy topics. The analogical model developed by the researchers was administered to 20…

  3. Ultraestructural study of effects of alkylphospholipid analogs against nematodes.

    Science.gov (United States)

    Sant' Anna, Viviane; Railbolt, Marcelle; Oliveira-Menezes, Aleksandra; Calogeropoulou, Theodora; Pinheiro, Jairo; de Souza, Wanderley

    2018-02-26

    Alkylphospholipid analogs were initially developed as anticancer agents and were later found to antiparasitic activity. Miltefosine is the prototype alkylphosphocholine and is the first oral treatment against visceral leishmaniasis. Here we investigated the effects of miltefosine and two ring-substituted alkylphosphocholine derivatives, TCAN26 and TC70, on the viability, morphology, and ultrastructure of the life stages of Caenorhabditis elegans and infective larvae of the parasite Strongyloides venezuelensis. Miltefosine displayed activity against C. elegans adults at low concentrations and was more effective than TCAN26 and TC70. Miltefosine inhibited the hatching of eggs, leading to embryonic lethality, and showed larvicidal activity against C. elegans and S. venezuelensis larvae after 24 h. Mitelfosine also induced alterations in the reproductive system of hermaphrodites, causing vulvar prolapse and general effects in the body wall. Electron microscopy analysis showed that miltefosine induced selective embryonic lethality, leading to cell death. Our results suggest that alkylphospholipid analogs are a potential new alternative for anti-nematode chemotherapy. Copyright © 2018. Published by Elsevier Inc.

  4. Analogical scaffolding and the learning of abstract ideas in physics: Empirical studies

    Directory of Open Access Journals (Sweden)

    Noah S. Podolefsky

    2007-09-01

    Full Text Available Previously, we proposed a model of student reasoning which combines the roles of representation, analogy, and layering of meaning—analogical scaffolding [Podolefsky and Finkelstein, Phys. Rev. ST Phys. Educ. Res. 3, 010109 (2007]. The present empirical studies build on this model to examine its utility and demonstrate the vital intertwining of representation, analogy, and conceptual learning in physics. In two studies of student reasoning using analogy, we show that representations couple to students’ existing prior knowledge and also lead to the dynamic formation of new knowledge. Students presented with abstract, concrete, or blended (both abstract and concrete representations produced markedly different response patterns. In the first study, using analogies to scaffold understanding of electromagnetic (EM waves, students in the blend group were more likely to reason productively about EM waves than students in the abstract group by as much as a factor of 3 (73% vs 24% correct, p=0.002. In the second study, examining representation use within one domain (sound waves, the blend group was more likely to reason productively about sound waves than the abstract group by as much as a factor of 2 (48% vs 23% correct, p=0.002. Using the analogical scaffolding model we examine when and why students succeed and fail to use analogies and interpret representations appropriately.

  5. Analogical scaffolding and the learning of abstract ideas in physics: Empirical studies

    Directory of Open Access Journals (Sweden)

    Noah D. Finkelstein

    2007-09-01

    Full Text Available Previously, we proposed a model of student reasoning which combines the roles of representation, analogy, and layering of meaning—analogical scaffolding [Podolefsky and Finkelstein, Phys. Rev. ST Phys. Educ. Res. 3, 010109 (2007]. The present empirical studies build on this model to examine its utility and demonstrate the vital intertwining of representation, analogy, and conceptual learning in physics. In two studies of student reasoning using analogy, we show that representations couple to students’ existing prior knowledge and also lead to the dynamic formation of new knowledge. Students presented with abstract, concrete, or blended (both abstract and concrete representations produced markedly different response patterns. In the first study, using analogies to scaffold understanding of electromagnetic (EM waves, students in the blend group were more likely to reason productively about EM waves than students in the abstract group by as much as a factor of 3 (73% vs 24% correct, p=0.002 . In the second study, examining representation use within one domain (sound waves, the blend group was more likely to reason productively about sound waves than the abstract group by as much as a factor of 2 (48% vs 23% correct, p=0.002 . Using the analogical scaffolding model we examine when and why students succeed and fail to use analogies and interpret representations appropriately.

  6. Materials licensing study. Phase 1. Task 9 report: evaluation of medical license renewals using the preprinted form. Volume 3

    International Nuclear Information System (INIS)

    Welles, B.W.; Varnado, G.B.

    1983-11-01

    This report describes the trial use of a preprinted license renewal form to reduce processing time. Other analyses (SAND83-7081/1 of 3 and SAND83-7081/2 of 3) have concluded that license renewals generate more deficiency letters than other actions, and that these contribute significantly to license processing time. This effort developed a preprinted form which utilized existing license data and standardized responses to complete most of a renewal application. This was mailed to selected licensees in advance of their license expiration. Results are tabulated in the report, but do not provide a statistically valid basis for conclusion on the effectiveness of this procedure. The report recommends continuing the use of a modified procedure, establishing a better basis for evaluation, and identifying opportunities for use in other license categories

  7. The neural substrate of analogical reasoning: an fMRI study.

    Science.gov (United States)

    Luo, Qian; Perry, Conrad; Peng, Danling; Jin, Zhen; Xu, Duo; Ding, Guosheng; Xu, Shiyong

    2003-10-01

    This study investigated the anatomical substrate of analogical reasoning using functional magnetic resonance imaging. In the study, subjects performed a verbal analogy task (e.g., soldier is to army as drummer is to band) and, to control for activation caused by purely semantic access, a semantic judgment task. Significant activation differences between the verbal analogy and the semantic judgment task were found bilaterally in the prefrontal cortex (right BA 11/BA 47 and left BA45), the fusiform gyrus, and the basal ganglia; left lateralized in the postero-superior temporal gyrus (BA 22) and the (para) hippocampal region; and right lateralized in the anterior cingulate. The role of these areas in analogical reasoning is discussed.

  8. Occupational Licensing

    OpenAIRE

    Morris M. Kleiner

    2000-01-01

    The study of the regulation of occupations has a long and distinguished tradition in economics. In this paper, I present the central arguments and unresolved issues involving the costs and benefits of occupational licensing. The main benefits that are suggested for occupational licensing involve improving quality for those persons receiving the service. In contrast, the costs attributed to this labor market institution are that it restricts the supply of labor to the occupation and thereby dr...

  9. General and specialized brain correlates for analogical reasoning: A meta-analysis of functional imaging studies.

    Science.gov (United States)

    Hobeika, Lucie; Diard-Detoeuf, Capucine; Garcin, Béatrice; Levy, Richard; Volle, Emmanuelle

    2016-05-01

    Reasoning by analogy allows us to link distinct domains of knowledge and to transfer solutions from one domain to another. Analogical reasoning has been studied using various tasks that have generally required the consideration of the relationships between objects and their integration to infer an analogy schema. However, these tasks varied in terms of the level and the nature of the relationships to consider (e.g., semantic, visuospatial). The aim of this study was to identify the cerebral network involved in analogical reasoning and its specialization based on the domains of information and task specificity. We conducted a coordinate-based meta-analysis of 27 experiments that used analogical reasoning tasks. The left rostrolateral prefrontal cortex was one of the regions most consistently activated across the studies. A comparison between semantic and visuospatial analogy tasks showed both domain-oriented regions in the inferior and middle frontal gyri and a domain-general region, the left rostrolateral prefrontal cortex, which was specialized for analogy tasks. A comparison of visuospatial analogy to matrix problem tasks revealed that these two relational reasoning tasks engage, at least in part, distinct right and left cerebral networks, particularly separate areas within the left rostrolateral prefrontal cortex. These findings highlight several cognitive and cerebral differences between relational reasoning tasks that can allow us to make predictions about the respective roles of distinct brain regions or networks. These results also provide new, testable anatomical hypotheses about reasoning disorders that are induced by brain damage. Hum Brain Mapp 37:1953-1969, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  10. Graduated licensing laws and fatal crashes of teenage drivers: a national study.

    Science.gov (United States)

    McCartt, Anne T; Teoh, Eric R; Fields, Michele; Braitman, Keli A; Hellinga, Laurie A

    2010-06-01

    The objective of the current study was to quantify the effects of the strength of US state graduated driver licensing laws and specific licensing components on the rate of teenage driver fatal crash involvements per 100,000 teenagers during 1996-2007. The strengths of state laws were rated good, fair, marginal, or poor based on a system developed previously by the Insurance Institute for Highway Safety. Analysis was based on quarterly counts of drivers involved in fatal crashes. Associations of overall ratings and individual licensing components with teenage crash rates were evaluated using Poisson regression, with the corresponding fatal crash rate for drivers ages 30-59 controlling for state- or time-dependent influences on crash rates unrelated to graduated licensing laws. Compared with licensing laws rated poor, laws rated good were associated with 30 percent lower fatal crash rates among 15- to 17-year-olds. Laws rated fair yielded fatal crash rates 11 percent lower. The longer the permit age was delayed, or the longer the licensing age was delayed, the lower the estimated fatal crash rates among 15- to 17-year-olds. Stronger nighttime restrictions were associated with larger reductions, and reductions were larger for laws limiting teenage passengers to zero or one than laws allowing two or more teenage passengers or laws without passenger restrictions. After the effects of any related delay in licensure were accounted for, an increase in the minimum learner's permit holding period showed no association with fatal crash rates. An increase in required practice driving hours did not appear to have an independent association with fatal crash rates. Graduated licensing laws that include strong nighttime and passenger restrictions and laws that delay the learner's permit age and licensing age are associated with lower teenage fatal crash rates. States that adopt such laws can expect to achieve substantial reductions in crash deaths.

  11. Barrier analogs: Long-term performance issues, preliminary studies, and recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Waugh, W.J. [Rust Geotech, Inc., Grand Junction, CO (United States). Environmental Sciences Lab.; Chatters, J.C.; Last, G.V.; Bjornstad, B.N.; Link, S.O. [Pacific Northwest Lab., Richland, WA (United States); Hunter, C.R. [Cascade Earth Sciences, La Grande, OR (United States)

    1994-02-01

    The US Department of Energy`s Hanford Protective Barrier Development Program is funding studies of natural analogs of the long-term performance of waste site covers. Natural-analog studies examine past environments as evidence for projecting the future performance of engineered structures. The information generated by analog studies is needed to (1) evaluate the designs and results of short term experiments and demonstrations, (2) formulate performance-modeling problems that bound expected changes in waste site environments, and (3) understand emergent system attributes that cannot be evaluated with short-term experiments or computer models. Waste site covers will be part of dynamic environmental systems with attributes that transcend the traits of engineered components. This report discusses results of the previously unreported preliminary studies conducted in 1983 and 1984. These results indicate that analogs could play an important role in predicting the long-term behavior of engineered waste covers. Layered exposures of glacial-flood-deposited gravels mantled with silt or sand that resemble contemporary barrier designs were examined. Bergmounds, another anomaly left by cataclysmic glacial floods, were also examined as analogs of surface gravel.

  12. Anandamide and analogous endocannabinoids: a lipid self-assembly study

    Energy Technology Data Exchange (ETDEWEB)

    Sagnella, Sharon M.; Conn, Charlotte E.; Krodkiewska, Irena; Mulet, Xavier; Drummond, Calum J.

    2014-09-24

    Anandamide, the endogenous agonist of the cannabinoid receptors, has been widely studied for its interesting biological and medicinal properties and is recognized as a highly significant lipid signaling molecule within the nervous system. Few studies have, however, examined the effect of the physical conformation of anandamide on its function. The study presented herein has focused on characterizing the self-assembly behaviour of anandamide and four other endocannabinoid analogues of anandamide, viz., 2-arachidonyl glycerol, arachidonyl dopamine, 2-arachidonyl glycerol ether (noladin ether), and o-arachidonyl ethanolamide (virodhamine). Molecular modeling of the five endocannabinoid lipids indicates that the highly unsaturated arachidonyl chain has a preference for a U or J shaped conformation. Thermal phase studies of the neat amphiphiles showed that a glass transition was observed for all of the endocannabinoids at {approx} -110 C with the exception of anandamide, with a second glass transition occurring for 2-arachidonyl glycerol, 2-arachidonyl glycerol ether, and virodhamine (-86 C, -95 C, -46 C respectively). Both anandamide and arachidonyl dopamine displayed a crystal-isotropic melting point (-4.8 and -20.4 C respectively), while a liquid crystal-isotropic melting transition was seen for 2-arachidonyl glycerol (-40.7 C) and 2-arachidonyl glycerol ether (-71.2 C). No additional transitions were observed for virodhamine. Small angle X-ray scattering and cross polarized optical microscopy studies as a function of temperature indicated that in the presence of excess water, both 2-arachidonyl glycerol and anandamide form co-existing Q{sub II}{sup G} (gyroid) and Q{sub II}{sup D} (diamond) bicontinuous cubic phases from 0 C to 20 C, which are kinetically stable over a period of weeks but may not represent true thermodynamic equilibrium. Similarly, 2-arachidonyl glycerol ether acquired an inverse hexagonal (HII) phase in excess water from 0 C to 40 C, while

  13. The neuromechanism underlying verbal analogical reasoning of metaphorical relations: an event-related potentials study.

    Science.gov (United States)

    Zhao, Ming; Meng, Huishan; Xu, Zhiyuan; Du, Fenglei; Liu, Tao; Li, Yongxin; Chen, Feiyan

    2011-11-24

    Using event-related potentials (ERPs), this study investigated the neuromechanism underlying verbal analogical reasoning of two different metaphorical relations: attributive metaphor and relational metaphor. The analogical reasoning of attributive metaphor (AM-AR) involves a superficial similarity between analogues, while the analogical reasoning of relational metaphor (RM-AR) requires a structural similarity. Subjects were asked to judge whether one word pair was semantically analogous to another word pair. Results showed that the schema induction stage elicited a greater N400 component at the right anterior scalp for the AM-AR and RM-AR tasks, possibly attributable to semantic processing of metaphorical word pairs. The N400 was then followed by a widely distributed P300 and a late negative component (LNC1) at the left anterior scalp. The P300 was possibly related to the formation of a relational category, while the LNC1 was possibly related to the maintenance of a reasoning cue in working memory. The analogy mapping stage elicited broadly distributed N400 and LNC2, which might indicate the presence of semantic retrieval and analogical transfer. In the answer production stage, all conditions elicited the P2 component due to early stimulus encoding. The largest P2 amplitude was in the RM-AR task. The RM-AR elicited a larger LPC than did the AM-AR, even though the baseline correction was taken as a control for the differential P2 effect. The LPC effect might suggest that relational metaphors involved more integration processing than attributive metaphors. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Analog study of the second re-extraction line of the La Hague plant

    International Nuclear Information System (INIS)

    Bory, M.; Francois, N.

    1966-01-01

    This study, realized on an analog computer, aims to determine the behavior of an uranium and plutonium re-extraction line in dynamical state. The system perturbations are temperature and acidity variations of aqueous phase and variations of the TBP of the solvent. The uranium contents variations are described. (A.L.B.)

  15. Study of $^{13}$Be through isobaric analog resonances in the Maya active target

    CERN Multimedia

    Riisager, K; Orr, N A; Jonson, B N G; Raabe, R; Fynbo, H O U; Nilsson, T

    We propose to perform an experiment with a $^{12}$Be beam and the Maya active target. We intend to study the ground state of $^{13}$Be through the population of its isobaric analog resonance in $^{13}$B. The resonance will be identified detecting its proton- and neutron-decay channels.

  16. Pre-licensed driving experience and car crash involvement during the learner and restricted, licence stages of graduated driver licensing: Findings from the New Zealand drivers study.

    Science.gov (United States)

    Begg, Dorothy J; Langley, John D; Brookland, Rebecca L; Ameratunga, Shanthi; Gulliver, Pauline

    2014-01-01

    The aim of this study was to determine whether pre-licence driving experiences, that is driving before beginning the licensing process, increased or decreased crash risk as a car driver, during the learner or the restricted licence stages of the graduated driver licensing system (GDLS). Study participants were 15-24 year old members of the New Zealand Drivers Study (NZDS) - a prospective cohort study of newly licensed car drivers. The interview stages of the NZDS are linked to, the three licensing stages of the GDLS: learner, restricted and full. Baseline demographic (age, ethnicity, residential location, deprivation), personality (impulsivity, sensation seeking, aggression) and, behavioural data, (including pre-licensed driving behaviour), were obtained at the learner licence interview. Data on distance driven and crashes that occurred at the learner licence and restricted licence stages, were reported at the restricted and full licence interviews, respectively. Crash data were also obtained from police traffic crash report files and this was combined with the self-reported crash data. The analysis of the learner licence stage crashes, when only supervised driving is allowed, was based on the participants who had passed the restricted licence test and undertaken the NZDS, restricted licence interview (n=2358). The analysis of the restricted licence stage crashes, when unsupervised driving is first allowed, was based on those who had passed the full licence test and completed the full licence interview (n=1428). After controlling for a range of demographic, personality, behavioural variables and distance driven, Poisson regression showed that the only pre-licence driving behaviour that showed a consistent relationship with subsequent crashes was on-road car driving which was associated with an increased risk of being the driver in a car crash during the learner licence period. This research showed that pre-licensed driving did not reduce crash risk among learner or

  17. Challenges of SMR licensing practices

    Energy Technology Data Exchange (ETDEWEB)

    Soderholm, K., E-mail: kristina.soderholm@fortum.com [Fortum Power, Espoo (Finland)

    2013-07-01

    The SMR licensing process has been under discussion in the USA and this trend is to be seen also in Europe. The current licensing practices in European countries vary from one another and some harmonization will be needed in the future for SMR licensing. This study goes through SMR specific features affecting the licensing process. Licensing processes in selected countries are studied in high level, trying to indicate the features that could be suitable for SMR licensing. (author)

  18. Drug Development of the Antimalarial Agent Artemisinin: Total Synthesis, Analog Synthesis, and Structure-Activity Relationship Studies

    Science.gov (United States)

    1990-08-15

    jHoluenesulfonyl hydrazide in tetrahydrofuran (THF), solvolysis of the ketal group and subsequent hydrazone formation was observed. Under base...ARTEMISININ: TOTAL SYNTHESIS , ANALOG SYNTHESIS , AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES mc Mitchell A. Avery, Ph.D. SRI International...Antimalarial Agent Artemisinin: Total Synthesis , Analog Synthesis and Structure-Activity Relationship Studies 12 PERSONAL AUTHOR(S) Mitchell A

  19. Final report of the AECL/SKB Cigar Lake analog study. AECL research No. AECL-10851

    Energy Technology Data Exchange (ETDEWEB)

    Cramer, J.J.; Smellie, J.A.T. (eds.)

    1994-07-15

    AECL has conducted natural analog studies on the Cigar Lake uranium deposit in northern Saskatchewan since 1984 as part of the Canadian Nuclear Fuel Waste Management Program. This report provides background information and summarizes the results of the study, emphasizing the analog aspects and the implications of modelling activities related to the performance assessment of disposal concepts for nuclear fuel wastes developed in both Canada and Sweden. The study was undertaken to obtain an understanding of the process involved in, and the effects of, steady-state water-rock interaction and trace-element migration in and around the deposit, including paleo-migration processes since the deposit was formed. To achieve these objectives, databases and models were produced to evaluate the equilibrium thermodynamic codes and databases; the role of colloids, organics, and microbes in transport processes for radionuclides; and the stability of UO2 and the influence of radiolysis on UO2 dissolution and radionuclide migration.

  20. Using Analogies in Teaching Physics: A Study on Latvian Teachers' Views and Experience

    Science.gov (United States)

    Jonane, Lolita

    2015-01-01

    The role of analogies as tools for teaching difficult science concepts has been widely discussed in science education. The application of analogies in the context of sustainable education involves richer potential. The purposeful use of appropriate analogies can facilitate analogical thinking and transfer skills, as well as develop abilities which…

  1. Comparative study of digital laser film and analog paper image recordings

    International Nuclear Information System (INIS)

    Lee, K.R.; Cox, G.G.; Templeton, A.W.; Preston, D.F.; Anderson, W.H.; Hensley, K.S.; Dwyer, S.J.

    1987-01-01

    The increase in the use of various imaging modalities demands higher quality and more efficacious analog image recordings. Laser electronic recordings with digital array prints of 4,000 x 5,000 x 12 bits obtained using laser-sensitive film or paper are being evaluated. Dry silver paper recordings are being improved and evaluated. High-resolution paper dot printers are being studied to determine their gray-scale capabilities. The authors evaluated the image quality, costs, clinical utilization, and acceptability of CT scans, MR images, digital subtraction angiograms, digital radiographs, and radionuclide scans recorded by seven different printers (three laser, three silver paper, and one dot) and compared the same features in conventional film recording. This exhibit outlines the technical developments and instrumentation of digital laser film and analog paper recorders and presents the results of the study

  2. Synthesis, biological evaluation, and docking studies of gigantol analogs as calmodulin inhibitors.

    Science.gov (United States)

    Reyes-Ramírez, Adelfo; Leyte-Lugo, Martha; Figueroa, Mario; Serrano-Alba, Trinidad; González-Andrade, Martín; Mata, Rachel

    2011-07-01

    Several analogs of gigantol (1) were synthesized to evaluate their effect on the complexes Ca(2+)-calmodulin (CaM) and Ca(2+)-CaM-CaM sensitive phosphodiesterase 1 (PDE1). The compounds belong to four structural groups including, 1,2-diphenylethanes (2-11), diphenylmethanes (13-15), 1,3-diphenylpropenones (16-18), and 1,3-diphenylpropanes (20-22). In vitro enzymatic studies showed that all compounds except 11 inhibited the complex Ca(2+)-CaM-PDE1 with IC(50) values ranging from 9 to 146 μM. On the other hand, all analogs but 11, 12 and 15 quenched the extrinsic fluorescence of the CaM biosensor hCaM-M124C-mBBr to different extent, then revealing different affinities to CaM; their affinity constants (K(m)) values were in the range of 3-80 μM. Molecular modeling studies indicated that all these compounds bound to CaM at the same site that the classical inhibitors trifluoperazine (TFP) and chlorpromazine (CPZ). Some of these analogs could be worthy candidates for developing new anti-tumor, local anesthetics, antidepressants, antipsychotic, or smooth muscle relaxant drugs, with anti-CaM properties due to their good affinity to CaM and the straightforwardness of their synthesis. In addition they could be valuable tools for the study of Ca(2+)-CaM functions. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  3. Antiproliferative effects of an analog of curcumin in Hep-2 cells: a comparative study with curcumin.

    Science.gov (United States)

    Kumaravel, Mohankumar; Sankar, Pajaniradje; Latha, Periyasamy; Benson, Chellakan S; Rukkumani, Rajagopalan

    2013-02-01

    Curcumin, the major active principle of Curcuma longa, is one of the promising, plant-derived, chemopreventive agents being studied for its anticarcinogenic and antioxidant properties. Hence, in our study, we aimed at testing the antiproliferative efficacy of an o-hydroxyl substituted analog of curcumin, bis demethoxy curcumin analog (BDMC-A), and comparing its efficacy with that of curcumin. BDMC-A was synthesised with a yield of 78% and 98% purity. Hep-2 cells and the MTT cell viability assay were used to examine cell proliferation. LDH assay and cell counts were performed to assess the cytotoxicity and anti-proliferative effects of the compound, respectively. Flow cytometry followed by Western blot were performed to investigate the cell cycle distribution. BDMC-A inhibited cell proliferation at a much lower concentration (IC50 20 microM) than curcumin (IC50 50 microM). Similar effects were observed in the LDH release and cell count assays. Flow cytometric studies using propidium iodide showed accumulation of cells in the G0/G1 phase and the arrest was further confirmed by immunoblotting of protein cyclin D1. BDMC-A was more potent in inhibiting the cells at a lower dose when compared with curcumin. Our results showed that the analog of curcumin is likely to possess more efficacy compared with curcumin in inhibiting cancer.

  4. U-Series Transport Studies at the Pena Blanca, Mexico Natural Analog Site

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Simmons; M. T. Murrell

    2001-05-31

    Natural analogs provide a line of evidence that supports the understanding of how natural and engineered processes would occur over long time frames and large spatial scales at a potential nuclear waste repository at Yucca Mountain, Nevada. Studies of U-series disequilibria within and around uranium deposits can provide valuable information on the timing of actinide mobility and hence the stability of a potential repository over geologic time scales. The Nopal I uranium deposit at Pena Blanca, Mexico, is situated in unsaturated tuff that is similar in composition to the Topopah Spring Tuff of Yucca Mountain and closely matches other evaluation criteria for suitable natural analogs. By modeling the observed radioactive isotope disequilibria at Nopal I, we can estimate the rates of sorption-desorption and dissolution-precipitation of the radionuclides over time. Such information is vital to the testing or validation of performance assessment models for geologic nuclear waste disposal.

  5. Analogical Thinking for Generation of Innovative Ideas: An Exploratory Study of Influential Factors

    Directory of Open Access Journals (Sweden)

    Eunyoung Kim

    2016-07-01

    Full Text Available Analogical thinking is one of the most effective tools to generate innovative ideas. It enables us to develop new ideas by transferring information from well-known domains and utilizing them in a novel domain. However, using analogical thinking does not always yield appropriate ideas, and there is a lack of consensus among researchers regarding the evaluation methods for assessing new ideas. Here, we define the appropriateness of generated ideas as having high structural and low superficial similarities with their source ideas. This study investigates the relationship between thinking process and the appropriateness of ideas generated through analogical thinking. We conducted four workshops with 22 students in order to collect the data. All generated ideas were assessed based on the definition of appropriateness in this study. The results show that participants who deliberate more before reaching the creative leap stage and those who are engaged in more trial and error for deciding the final domain of a new idea have a greater possibility of generating appropriate ideas. The findings suggest new strategies of designing workshops to enhance the appropriateness of new ideas.

  6. Studies towards the synthesis of ATP analogs as potential glutamine synthetase inhibitors

    CSIR Research Space (South Africa)

    Salisu, S

    2011-05-01

    Full Text Available In research directed at the development of adenine triphosphate (ATP) analogs as potential glutamine synthetase (GS) inhibitors, adenine and allopurinol derivatives have been synthesized either as novel ATP analogs or as scaffolds...

  7. Final report of the AECL/SKB Cigar Lake analog study

    International Nuclear Information System (INIS)

    Cramer, J.

    1994-05-01

    The Cigar Lake uranium deposit is located in northern Saskatchewan, Canada. The 1.3-billion-year-old deposit is located at a depth of about 450 m below surface in a water-saturated sandstone at the unconformity contact with the high-grade metamorphic rocks of the Canadian Shield. The Cigar Lake deposit has many features that parallel those being considered within the Canadian concept for disposal of nuclear fuel waste. The study of these natural structures and processes provides valuable insight toward the eventual design and site selection of a nuclear fuel waste repository. The main feature of this analog is the absence of any indication on the surface of the rich uranium ore 450 m below. This indicates that the combination of natural barriers has been effective in isolating the uranium ore from the surface environment. More specifically, the deposit provides analog information relevant to the stability of UO 2 fuel waste, the performance of clay-based barriers, radionuclide migration, colloid formation, radiolysis, fission-product geochemistry and general aspects of water-rock interaction. The main geochemical studies on this deposit focus on the evolution of groundwater compositions in the deposit and on their redox chemistry with respect to the uranium, iron and sulphide systems. Since 1984, through cooperation from the owners of the Cigar Lake deposit, analog studies have been conducted. AECL, with support from Ontario Hydro under the auspices of the CANDU Owners Group, initiated international participation in 1989 through collaboration with the Swedish Nuclear Fuel and Waste Management Company (SKB) and, more recently, with the Los Alamos National Laboratory (LANL). This report gives the results of the various studies carried out during the 3-year collaboration between AECL and SKB, as well as a summery of the LANL study. It provides detailed information on the generated databases and models, and integrates this information into conclusions for use in safety

  8. ITER Licensing Process Follow-up: A Part of K-DEMO Safety Study

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Myoungsuk; Oh, Kyemin; Heo, Gyunyoung [Kyung Hee Univ., Yongin (Korea, Republic of); Lee, Hyoen Gon [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The fusion DEMO program of Korea (referred as K-DEMO) has been progressed since 2009 to take advantages of an early mover, while carrying out scientific researches on KSTAR and International Thermonuclear Experimental Reactor (ITER). The K-DEMO program is a huge program and is in second phase planed for R and D from 2012 to 2021. One of the big part of this program, the fusion regulation and licensing in South Korea, can be classified into following three stages: the licensing of the KSTAR classified to a radiation generating device on the basis of the existing nuclear regulations, the verification of the design of the Test Blanket Module (TBM) and minimization of occupational irradiation damages due to tritium behaviors for ITER, and fundamental safety analysis, as a part of K-DEMO program with domestic universities funded by National Fusion Research Institute of Korea (NFRI). Kyung Hee University has studied safety analysis of K-DEMO since 2010, and surveyed ITER safety regulation and licensing process since 2012. In 2013, NFRI has carried out 'Development, Operation, and Management of core technologies for ITER' to secure the core original technologies and expend the base of domestic specialist at a fusion area by pursuing and developing non-supply technologies for ITER.

  9. Archaeological analogous and industrials for deep storage: study of the archaeological metallic piece

    International Nuclear Information System (INIS)

    Criado Portal, A. J.; Martinez Garcia, J. A.; Calabres Molina, R.; Garcia abajo, A.; Penco Valenzuela, F.; Lecanda Esteban, J. A.; Garcia Bartual, M.; Jimenez Gonzalez, J. M.; Bravo Munoz, E.; Rodriguez Lobo, L. M.; Fernandez Cascos, T.; Fernandes Cordero, O.; Montero Ruiz, I.

    2000-01-01

    The aim of present research is to obtain information about archaeological analogous of iron and steel, useful for the model of deep geological repository (AGP). The analogous examined have remained buried between 1400 and 2400 years, in very assorted geochemical environments. The extraction of the archaeological pieces has been accomplished according to normalised protocols, trying to carry to the laboratory so the piece as its burial environment, avoiding all possible pollution. Trying to the archaeological analogous could provide valuable information to the AGP model, the study has been directed to related the physical-chemical characteristics of the terrain respect to the deterioration of the archaeological metallic piece. The geology of the surrounding terrain to the archaeological deposit, the geomorphological study of the terrain and data from the analysis of ground: pH, wetness, porosity, organic matter contents, bacteria presence, sulphates, carbonates, chlorides, etc., have allowed to explain the physical-chemical phenomena suffered by the archaeological iron and steel pieces. Also, an exhaustive study of the archaeological piece has been accomplished, concerning the microstructure of the corrosion layer and of the not deteriorated metallic rest. Obtained information concerns different items, such as corrosion velocity and formations of oxide layers, diffusion of chemical elements from the corrosion layer to the metal and viceversa, and structural changes in oxide layers and in the metallic remains by structural ageing. Obtained data have allowed to develop a mathematical model for calculation of corrosion velocity in buried iron and steels, based on physical-chemical variables of grounds, chemical composition and thermomechanical treatment given to the metal during its manufacture. (Author)

  10. Natural analog study of engineered protective barriers at the Hanford Site

    International Nuclear Information System (INIS)

    Bjornstad, B.N.; Teel, S.S.

    1993-09-01

    The purpose of this study is to evaluate surficial sedimentary deposits formed in the Pasco Basin over the geologic past as analogs for engineered protective barriers. Evidence for likely changes to be expected in an engineered barrier are preserved in geologically recent deposits. Although the design life of the engineered bonier is only 1,000 years, soils and sediments of this age are uncommon in the Pasco Basin. The evidence of and probability for the following natural processes that could adversely affect the long-term stability of an engineered protective barrier reviewed in this report are deflation by wind, soil compaction, soil eluviation/illuviation, bioturbation, and cryoturbation

  11. Reasoning by analogy: rational foundation of natural analogue studies. [Application to radioactive waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J.-C. (CEA Centre d' Etudes Nucleaires de Fontenay-aux Roses, (France). DRDD/SESD)

    1992-01-01

    Long-term extrapolations concerning the safety of a nuclear waste repository cannot be satisfactorily made on the sole basis of short-term laboratory investigations. Most nuclear countries have hence developed an approach relying on the following research directions: 1. laboratory experiments; 2. in situ testing; 3. modeling; and 4. natural analogues, which are the only means by which very slow mechanisms can be identified and by which long-term predictions of models can be tested for pertinence (if not truly validated). Although the field of natural analogues has grown very rapidly in recent years, receiving support from varied specialists and institutions involved in radioactive waste disposal, there is not yet a full consensus on their actual usefulness. More problematic is the criticism sometimes made that analogical reasoning is not ''true science'' and that information retrieved from the study of natural analogues will always remain questionable. The present paper gives some clues about the exact status of reasoning by analogy, compared to more ''scientific'' ways of deriving information from investigated systems. It is not a thorough discussion of this very complex, and by far too philosophical issue but we hope, at least, to present to readers of papers devoted to natural analogue studies arguments showing that this approach has some sound foundation. (author).

  12. Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study.

    Science.gov (United States)

    Taha, Muhammad; Irshad, Maryam; Imran, Syahrul; Chigurupati, Sridevi; Selvaraj, Manikandan; Rahim, Fazal; Ismail, Nor Hadiani; Nawaz, Faisal; Khan, Khalid Mohammed

    2017-12-01

    Piperazine Sulfonamide analogs (1-19) have been synthesized, characterized by different spectroscopic techniques and evaluated for α-amylase Inhibition. Analogs 1-19 exhibited a varying degree of α-amylase inhibitory activity with IC 50 values ranging in between 1.571 ± 0.05 to 3.98 ± 0.397 μM when compared with the standard acarbose (IC 50  = 1.353 ± 0.232 μM). Compound 1, 2, 3 and 7 showed significant inhibitory effects with IC 50 value 2.348 ± 0.444, 2.064 ± 0.04, 1.571 ± 0.05 and 2.118 ± 0.204 μM, respectively better than the rest of the series. Structure activity relationships were established. Molecular docking studies were performed to understand the binding interaction of the compounds. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  13. Study for material analogs of FeSb2: Material design for thermoelectric materials

    Science.gov (United States)

    Kang, Chang-Jong; Kotliar, Gabriel

    2018-03-01

    Using the ab initio evolutionary algorithm (implemented in uspex) and electronic structure calculations we investigate the properties of a new thermoelectric material FeSbAs, which is a material analog of the enigmatic thermoelectric FeSb2. We utilize the density functional theory and the Gutzwiller method to check the energetics. We find that FeSbAs can be made thermodynamically stable above ˜30 GPa. We investigate the electronic structure and thermoelectric properties of FeSbAs based on the density functional theory and compare with those of FeSb2. Above 50 K, FeSbAs has higher Seebeck coefficients than FeSb2. Upon doping, the figure of merit becomes larger for FeSbAs than for FeSb2. Another material analog FeSbP, was also investigated, and found thermodynamically unstable even at very high pressure. Regarding FeSb2 as a member of a family of compounds (FeSb2, FeSbAs, and FeSbP) we elucidate what are the chemical handles that control the gaps in this series. We also investigate solubility (As or P for Sb in FeSb2) we found As to be more soluble. Finally, we study a two-band model for thermoelectric properties and find that the temperature dependent chemical potential and the presence of the ionized impurities are important to explain the extremum in the Seebeck coefficient exhibited in experiments for FeSb2.

  14. Incorporating Climate Change in Flow Regime Alteration Studies in Hydropower Licensing

    Science.gov (United States)

    Rheinheimer, D. E.; Akhbari, M.; Peek, R.; Yarnell, S. M.; Null, S. E.; Viers, J. H.

    2013-12-01

    The U.S. Federal Energy Regulatory Commission has yet to mandate incorporation of anticipated climate change effects on hydropower system operations when assessing environmental impacts from the renewal of hydropower licenses. One stated reason is the lack of specific project-level specificity in future impacts. We demonstrate how a hydropower system operations model, incorporating the latest climatological realizations (3 GCMs x RCPs 4.5 and 8.5), can be used to assess environmental impacts generally, and hydrological flow alterations in particular, during the hydropower licensing process. We demonstrate that we can, in fact, quantify project-level impacts from climate change, albeit within the context of quantified uncertainty about non-stationary future conditions. The systems operations model analysis encompasses the combined effects of the Yuba River Development Project and Yuba-Bear Drum-Spaulding Projects, an interconnected series of complex hydropower systems located in the Sierra Nevada, California. Daily water system operations are simulated using a monthly-scale optimization model for hydropower decisions. Though there is inherent uncertainty generated by the modeling process and operational assumptions (e.g., static energy demand), there are sufficient data, modeling techniques, and analytical approaches to assess the how management decisions made today may be confounded by non-stationary hydroclimates in 30-50 years, which is the duration of most hydropower licenses. Such decisions need to include adaptive management approaches to address not only non-stationary hydroclimates, but also cumulative impacts to ecological functions and processes caused by serial flow manipulation. This study can help provide the scientific guidance needed to improve climate change policy in hydropower system planning.

  15. License renewal

    International Nuclear Information System (INIS)

    Newberry, S.

    1993-01-01

    This article gives an overview of the process of license renewal for nuclear power plants. It explains what is meant by license renewal, the significance of license renewal, and goes over key elements involved in the process of license renewal. Those key elements are NRC requirements embodied in 10 CFR Part 54 (Reactor Safety) and 10 CFR Part 51 (Environmental Issues). In addition Industry Reports must be developed and reviewed. License renewal is essentially the process of applying for a 20 year extension to the original 40 year operating license granted for the plant. This is a very long term process, which involves a lot of preparation, and compliance with regulatory rules and guidelines. In general it is a process which is expected to begin when plants reach an operating lifetime of 20 years. It has provisions for allowing the public to become involved in the review process

  16. Software Licensing

    OpenAIRE

    Nygrýnová, Dominika

    2014-01-01

    Summary: Software Licensing The thesis deals with different practical aspects of commercial software licensing from the perspective of the Czech legal system. The focus is put on software license agreement as the most important legal instrument granting rights of use for computer programs. The thesis opens with a summary of Czech legislation in force in this area in the context of European community law and international law. The legislation in effect is largely governed by the Copyright Act....

  17. Final report of the AECL/SKB Cigar Lake analog study

    International Nuclear Information System (INIS)

    Cramer, J.J.

    1994-07-01

    The Cigar Lake uranium deposit is located in northern Saskatchewan, Canada. The 1.3-billion-year-old deposit is located at a depth of about 450 m below surface in a water-saturated sandstone at the unconformity contact with the high-grade metamorphic rocks of the Canadian Shield. The uranium mineralization, consisting primarily of uraninite (UO 2 ), is surrounded by a clay-rich halo in both sandstone and basement rocks, and remains extremely well preserved and intact. The average grade of the mineralization is ∼ 8 wt.% U; locally grades are as high as ∼ 55 wt.%U. The Cigar lake deposit has many features that parallel those being considered within the Canadian concept for disposal of nuclear fuel waste. Specifically, the deposit provides analog information relevant to the stability of UO 2 fuel waste, the performance of clay-based barriers, radionuclide migration, colloid formation, radiolysis, fission-product geochemistry and general aspects of water-rock interaction. The main geochemical studies on this deposit focus on the evolution of groundwater compositions in the deposit and on their redox chemistry with respect to the uranium, iron and sulphide systems. Since 1984, through cooperation from the owners of the Cigar lake deposit, analog studies have been conducted. AECL, with support from Ontario Hydro under the auspices of the CANDU Owners Group, initiated international participation in 1989 through collaboration with the Swedish Nuclear Fuel and Waste Management Company (SKB) and, more recently, with the Los Alamos National Laboratory (LANL). This report gives the results of the various studies carried out during the 3-year collaboration between AECL and SKB, as well as a summary of the LANL study. It provides detailed information on the generated databases and models, and integrates this information into conclusions for use in safety assessment of the Canadian, Swedish and United States disposal concepts. 15 refs., 25 figs., 55 tabs

  18. Neutron-skin thickness from the study of the anti-analog giant dipole resonance

    NARCIS (Netherlands)

    Krasznahorkay, A.; Stuhl, L.; Csatlós, M.; Algora, A.; Gulyás, J.; Timár, J.; Paar, N.; Vretenar, D.; Boretzky, K.; Heil, M.; Litvinov, Yu A.; Rossi, D.; Scheidenberger, C.; Simon, H.; Weick, H.; Bracco, A.; Brambilla, S.; Blasi, N.; Camera, F.; Giaz, A.; Million, B.; Pellegri, L.; Riboldi, S.; Wieland, O.; Altstadt, S.; Fonseca, M.; Glorius, J.; Göbel, K.; Heftrich, T.; Koloczek, A.; Kräckmann, S.; Langer, C.; Plag, R.; Pohl, M.; Rastrepina, G.; Reifarth, R.; Schmidt, S.; Sonnabend, K.; Weigand, M.; Harakeh, M. N.; Kalantar-Nayestanaki, N.; Rigollet, C.; Bagchi, S.; Najafi, M. A.; Aumann, T.; Atar, L.; Heine, M.; Holl, M.; Movsesyan, A.; Schrock, P.; Volkov, V.; Wamers, F.; Fiori, E.; Löher, B.; Marganiec, J.; Savran, D.; Johansson, H. T.; Fernández, P. Diaz; Garg, U.; Balabanski, D. L.

    2012-01-01

    The gamma-decay of the anti-analog of the giant dipole resonance (AGDR) has been measured to the isobaric analog state excited in the p(124Sn,n) reaction at a beam energy of 600 MeV/nucleon. The energy of the transition was also calculated with state-of-the-art self-consistent random-phase

  19. Optical analogy. Synthesis report

    International Nuclear Information System (INIS)

    1965-01-01

    The authors report the study of conditions under which light attenuation (reflection, diffusion, absorption) and the attenuation of some radiations (notably thermal neutrons) can be described with analogical calculations. The analogy between light physical properties and neutron properties is not searched for, but the analogy between their attenuation characteristics. After having discussed this possible analogy, they propose a mathematical formulation of neutron and optical phenomena which could theoretically justify the optical analogy. The second part reports a more practical study of optics problems such as the study of simple optics materials and illumination measurements, or more precisely the study of angular distributions of optical reflections, a determination of such angular distributions, and an experimental determination of the albedo

  20. Study on the License Mode of Value-Added Exploitation of Public Sector Information

    OpenAIRE

    Hua, Haiying; Zhu, Shuren

    2013-01-01

    How to license PSI (public sector information) to those commercial reusers has become so urgent and important issue. The paper discussed the different license mode of value-added exploitation of Public Sector Information in UK and United States. Based on the investigation and comparison, the paper proposed some valuable suggestions on the construction of license mode of value-added exploitation of PSI in China: A clear attribution of property of public sector information and a clear range ...

  1. Licensing reform: a case study in public participation in the nuclear field

    International Nuclear Information System (INIS)

    Nordlinger, M.S.

    1993-01-01

    Political process and legal procedures join to accord the public a significant role in nuclear energy policy decision-making in the United States. We changed the two-stage license process in a combined license process with no separation between the construction and operating license, the policy statement requests public comment, allowing days for responses. It is a middle way between information and taking part in decision

  2. Radiopharmaceutical licensing

    International Nuclear Information System (INIS)

    Mather, S.J.

    1992-01-01

    Recent health service legislation, and especially the loss of crown immunity has once again focussed attention on the arrangements for licensing of radiopharmaceuticals. The aim of the article is to describe in general terms the UK licensing system and in particular to provide guidance to those responsible for the supply of radiopharmaceuticals in hospitals. (author)

  3. Reactor licensing

    International Nuclear Information System (INIS)

    Harvie, J.D.

    2002-01-01

    This presentation discusses reactor licensing and includes the legislative basis for licensing, other relevant legislation , the purpose of the Nuclear Safety and Control Act, important regulations, regulatory document, policies, and standards. It also discusses the role of the CNSC, its mandate and safety philosophy

  4. Is it time for studying real-life debiasing? Evaluation of the effectiveness of an analogical intervention technique.

    Science.gov (United States)

    Aczel, Balazs; Bago, Bence; Szollosi, Aba; Foldes, Andrei; Lukacs, Bence

    2015-01-01

    The aim of this study was to initiate the exploration of debiasing methods applicable in real-life settings for achieving lasting improvement in decision making competence regarding multiple decision biases. Here, we tested the potentials of the analogical encoding method for decision debiasing. The advantage of this method is that it can foster the transfer from learning abstract principles to improving behavioral performance. For the purpose of the study, we devised an analogical debiasing technique for 10 biases (covariation detection, insensitivity to sample size, base rate neglect, regression to the mean, outcome bias, sunk cost fallacy, framing effect, anchoring bias, overconfidence bias, planning fallacy) and assessed the susceptibility of the participants (N = 154) to these biases before and 4 weeks after the training. We also compared the effect of the analogical training to the effect of 'awareness training' and a 'no-training' control group. Results suggested improved performance of the analogical training group only on tasks where the violations of statistical principles are measured. The interpretation of these findings require further investigation, yet it is possible that analogical training may be the most effective in the case of learning abstract concepts, such as statistical principles, which are otherwise difficult to master. The study encourages a systematic research of debiasing trainings and the development of intervention assessment methods to measure the endurance of behavior change in decision debiasing.

  5. Is it time for studying real-life debiasing? Evaluation of the effectiveness of an analogical intervention technique

    Directory of Open Access Journals (Sweden)

    Balazs eAczel

    2015-08-01

    Full Text Available The aim of this study was to initiate the exploration of debiasing methods applicable in real-life settings for achieving lasting improvement in decision-making competence regarding multiple decision biases. Here, we tested the potentials of the analogical encoding method for decision debiasing. The advantage of this method is that it can foster the transfer from learning abstract principles to improving behavioral performance. For the purpose of the study, we devised an analogical debiasing technique for ten biases (covariation detection, insensitivity to sample size, base rate neglect, regression to the mean, outcome bias, sunk cost fallacy, framing effect, anchoring bias, overconfidence bias, planning fallacy and assessed the susceptibility of the participants (N = 154 to these biases before and four weeks after the training. We also compared the effect of the analogical training to the effect of an ‘awareness training’ and a ‘no-training’ control group. Results suggested improved performance of the analogical training group only on tasks where the violations of statistical principles are measured. The interpretation of these findings require further investigation, yet it is possible that analogical training may be the most effective in the case of learning abstract concepts, such as statistical principles, which are otherwise difficult to master. The study encourages a systematic research of debiasing trainings and the development of intervention assessment methods to measure the endurance of behavior change in decision debiasing.

  6. Contribution of studies for environmental licensing to the knowledge of Santa Catarina avifauna in southern Brazil

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Guimarães Azevedo

    2006-03-01

    Full Text Available The knowledge generated by studies for environmental licensing, even with reduced field samplings, can contribute to the recording of species of avifauna or actually extends the distribution in places of low knowledge. This study presents data obtained from preliminary reports of impact where the avifauna in seven projects in different ecosystems of Santa Catarina state was diagnosed between January 2001 and January 2004. Sightings had occurred, mainly, by visual or auditory contacts, using binoculars, hand-recorders and field guides. A total of 232 species of birds had been registered, increasing the known distribution by 66 species in different regions of Santa Catarina. The habitat most damaged by entrepreneurial activity was the forest, a factor of concern regarding the conservation of the avifauna that relied upon it. In general, the risk factors associated with the avifauna in Santa Catarina state are environmental degradation, capture of wildlife for breeding in captivity and, hunting for food.

  7. Controlled dual release study of curcumin and a 4-aminoquinoline analog from gum acacia containing hydrogels

    CSIR Research Space (South Africa)

    Aderibigbe, BA

    2014-10-01

    Full Text Available The potential of gum acacia containing hydrogels as controlled dual-drug delivery systems for antiprotozoal agents was investigated. 4-Aminoquinoline analog and curcumin were selected as model drugs because they exhibit antiprotozoal activity...

  8. Thermal expansion in 3d-metal Prussian Blue Analogs-A survey study

    International Nuclear Information System (INIS)

    Adak, Sourav; Daemen, Luke L.; Hartl, Monika; Williams, Darrick; Summerhill, Jennifer; Nakotte, Heinz

    2011-01-01

    We present a comprehensive study of the structural properties and the thermal expansion behavior of 17 different Prussian Blue Analogs (PBAs) with compositions M II 3 [(M') III (CN) 6 ] 2 .nH 2 O and M II 2 [Fe II (CN) 6 ].nH 2 O, where M II =Mn, Fe, Co, Ni, Cu and Zn, (M') III =Co, Fe and n is the number of water molecules, which range from 5 to 18 for these compounds. The PBAs were synthesized via standard chemical precipitation methods, and temperature-dependent X-ray diffraction studies were performed in the temperature range between -150 deg. C (123 K) and room-temperature. The vast majority of the studied PBAs were found to crystallize in cubic structures of space groups Fm3-bar m, F4-bar 3m and Pm3-bar m. The temperature dependence of the lattice parameters was taken to compute an average coefficient of linear thermal expansion in the studied temperature range. Of the 17 compounds, 9 display negative values for the average coefficient of linear thermal expansion, which can be as large as 39.7x 1 0 -6 K -1 for Co 3 [Co(CN) 6 ] 2 .12H 2 O. All of the M II 3 [Co III (CN) 6 ] 2 .nH 2 O compounds show negative thermal expansion behavior, which correlates with the Irving-Williams series for metal complex stability. The thermal expansion behavior for the PBAs of the M II 3 [Fe III (CN) 6 ] 2 .nH 2 O family are found to switch between positive (for M=Mn, Co, Ni) and negative (M=Cu, Zn) behavior, depending on the choice of the metal cation (M). On the other hand, all of the M II 2 [Fe II (CN) 6 ].nH 2 O compounds show positive thermal expansion behavior. - Graphical Abstract: The structure of Prussian Blue analogs (PBAs) consists of two types of metal centered octahedral units connected by cyanide ligand. Lattice and interstitial water molecules are present in these framework structures. All the PBAs of the M 3 [Co(CN) 6 ] 2 .nH 2 O family show negative thermal expansion (NTE) behavior. The lattice parameters and magnitude of NTE correlates inversely with the Irving

  9. Safeguards Licensing Aspects of a Future Gen IV Test Facility - a Case Study

    International Nuclear Information System (INIS)

    Lindell, M. Aberg; Grape, S.; Hakansson, A.; Svaerd, S. Jacobsson

    2010-01-01

    The scope of this study covers safeguards licensing aspects of a possible future Gen IV demonstration facility. As a basis for the investigation, the facility was assumed to be located in Sweden, comprising a lead-cooled fast reactor and a reprocessing plant with fuel fabrication. The aim has been to identify safeguards requirements that may be set by the IAEA and the Swedish Radiation Safety Authority, and also to suggest how the safeguards system could be implemented in practice. The changed usage and handling of nuclear fuel, as compared to that of today, has been examined in order to determine how today's safeguards measures can be modified and extended to meet the needs of the demonstration facility. This work is part of GENIUS, the Swedish Gen IV research and development programme, which emphasizes lead-cooled fast reactors. (author)

  10. An evaluation of scanpath-comparison and machine-learning classification algorithms used to study the dynamics of analogy making.

    Science.gov (United States)

    French, Robert M; Glady, Yannick; Thibaut, Jean-Pierre

    2017-08-01

    In recent years, eyetracking has begun to be used to study the dynamics of analogy making. Numerous scanpath-comparison algorithms and machine-learning techniques are available that can be applied to the raw eyetracking data. We show how scanpath-comparison algorithms, combined with multidimensional scaling and a classification algorithm, can be used to resolve an outstanding question in analogy making-namely, whether or not children's and adults' strategies in solving analogy problems are different. (They are.) We show which of these scanpath-comparison algorithms is best suited to the kinds of analogy problems that have formed the basis of much analogy-making research over the years. Furthermore, we use machine-learning classification algorithms to examine the item-to-item saccade vectors making up these scanpaths. We show which of these algorithms best predicts, from very early on in a trial, on the basis of the frequency of various item-to-item saccades, whether a child or an adult is doing the problem. This type of analysis can also be used to predict, on the basis of the item-to-item saccade dynamics in the first third of a trial, whether or not a problem will be solved correctly.

  11. Analog earthquakes

    International Nuclear Information System (INIS)

    Hofmann, R.B.

    1995-01-01

    Analogs are used to understand complex or poorly understood phenomena for which little data may be available at the actual repository site. Earthquakes are complex phenomena, and they can have a large number of effects on the natural system, as well as on engineered structures. Instrumental data close to the source of large earthquakes are rarely obtained. The rare events for which measurements are available may be used, with modfications, as analogs for potential large earthquakes at sites where no earthquake data are available. In the following, several examples of nuclear reactor and liquified natural gas facility siting are discussed. A potential use of analog earthquakes is proposed for a high-level nuclear waste (HLW) repository

  12. Nuclear plant license renewal

    International Nuclear Information System (INIS)

    Gazda, P.A.; Bhatt, P.C.

    1991-01-01

    During the next 10 years, nuclear plant license renewal is expected to become a significant issue. Recent Electric Power Research Institute (EPRI) studies have shown license renewal to be technically and economically feasible. Filing an application for license renewal with the Nuclear Regulatory Commission (NRC) entails verifying that the systems, structures, and components essential for safety will continue to perform their safety functions throughout the license renewal period. This paper discusses the current proposed requirements for this verification and the current industry knowledge regarding age-related degradation of structures. Elements of a license renewal program incorporating NRC requirements and industry knowledge including a schedule are presented. Degradation mechanisms for structural components, their significance to nuclear plant structures, and industry-suggested age-related degradation management options are also reviewed

  13. Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer

    Directory of Open Access Journals (Sweden)

    Yadav DK

    2017-06-01

    Full Text Available Dharmendra K Yadav,1 Surendra Kumar,2 Saloni,1 Harpreet Singh,3 Mi-hyun Kim,1 Praveen Sharma,4 Sanjeev Misra,4 Feroz Khan5 1Department of Pharmacy, College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, Republic of Korea; 2Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Babu Banarasi Das Northern India Institute of Technology, Lucknow, 3Department of Bioinformatics, Indian Council of Medical Research, New Delhi, 4Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 5Metabolic & Structural Biology Department, CSIR– Central Institute of Medicinal & Aromatic Plant, Lucknow, India Abstract: Withanolides are a group of pharmacologically active compounds present in most prodigal amounts in roots and leaves of Withania somnifera (Indian ginseng, one of the most important medicinal plants of Indian traditional practice of medicine. Withanolides are steroidal lactones (highly oxygenated C-28 phytochemicals and have been reported to exhibit immunomodulatory, anticancer and other activities. In the present study, a quantitative structure activity relationship (QSAR model was developed by a forward stepwise multiple linear regression method to predict the activity of withanolide analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90. Similarly, cross-validation regression coefficient (rCV2=0.85 of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91. In particular, compounds CID_73621, CID_435144, CID_301751 and CID_3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, withanolide A, withaferin A, CID_10413139, CID_11294368, CID_53477765, CID_135887, CID_301751 and CID_3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU and

  14. Hole Burning Imaging Studies of Cancerous and Analogous Normal Ovarian Tissues Utilizing Organelle Specific Dyes

    Energy Technology Data Exchange (ETDEWEB)

    Matsuzaki, Satoshi [Iowa State Univ., Ames, IA (United States)

    2004-01-01

    Presented in this dissertation is the successful demonstration that nonphotochemical hole burning (NPWB) imaging can be used to study in vitro tissue cellular systems for discerning differences in cellular ultrastructures due to cancer development. This has been accomplished with the surgically removed cancerous ovarian and analogous normal peritoneal tissues from the same patient and the application of a fluorescent mitochondrion specific dye, Molecular Probe MitoFluor Far Red 680 (MF680), commonly known as rhodamine 800, that has been proven to exhibit efficient NPHB. From the results presented in Chapters 4 and 5 , and Appendix B, the following conclusions were made: (1) fluorescence excitation spectra of MF680 and confocal microscopy images of thin sliced tissues incubated with MF680 confirm the site-specificity of the probe molecules in the cellular systems. (2) Tunneling parameters, {lambda}{sub 0} and σΛ, as well as the standard hole burning parameters (namely, γ and S), have been determined for the tissue samples by hole growth kinetics (HGK) analyses. Unlike the preliminary cultured cell studies, these parameters have not shown the ability to distinguish tissue cellular matrices surrounding the chromophores. (3) Effects of an external electric (Stark) field on the nonphotochemical holes have been used to determine the changes in permanent dipole moment (fΔμ) for MF680 in tissue samples when burn laser polarization is parallel to the Stark field. Differences are detected between fΔμs in the two tissue samples, with the cancerous tissue exhibiting a more pronounced change (1.35-fold increase) in permanent dipole moment change relative to the normal analogs. It is speculated that the difference may be related to differences in mitochondrial membrane potentials in these tissue samples. (4) In the HGK mode, hole burning imaging (HBI) of cells adhered to coverslips and cooled to liquid helium temperatures in the complete absence of

  15. Stereoselective synthesis of an iodinated resveratrol analog: Preliminary bioevaluation studies of the radioiodinated species

    Energy Technology Data Exchange (ETDEWEB)

    Dhyani, Manish V.; Kameswaran, Mythili; Korde, Aruna G.; Pandey, Usha [Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Chattopadhyay, Subrata [Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Banerjee, Sharmila, E-mail: sharmila@barc.gov.i [Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2011-07-15

    Stereoselective synthesis of an E-hydroxystilbene has been carried out using the McMurry reaction. Synthesis of a monoiodinated hydroxystilbene has been carried out by a McMurry cross-coupling reaction. For the purpose of biological evaluation, the facile electrophilic substitution route has been attempted to radioiodinate it with {sup 125}I. The HPLC pattern of the radioiodinated hydroxystilbene, which could be obtained in >90% radiochemical purity, was found to be identical to that of its non-radioactive analog that has been independently prepared using the McMurry cross-coupling route. In vitro cell uptake studies were carried out in breast cancer cells MCF7, overexpressing estrogen receptors. In vivo biodistribution studies in female Swiss mice show a uterine uptake of 0.85{+-}0.4% ID/g at 3 h.p.i. with a uterus to muscle ratio of 2.83. Uptake in the thyroid was insignificant indicating good in vivo stability of the radioiodinated hydroxystilbene.

  16. Cytochrome P450 2C9 Type II Binding Studies on Quinoline-4-carboxamide Analogs

    Science.gov (United States)

    Peng, Chi-Chi; Cape, Jonathan L.; Rushmore, Tom; Crouch, Gregory J.; Jones, Jeffrey P.

    2009-01-01

    CYP2C9 is a significant P450 protein responsible for drug metabolism. With the increased use of heterocyclic compounds in drug design, a rapid and efficient pre-drug screening of these potential type II binding compounds is essential to avoid adverse drug reactions. To understand binding modes, we use quinoline-4-carboxamide analogs to study the factors that determine the structure-activity relationships. The results of this study suggest that the more accessible pyridine with the nitrogen para to the linkage can coordinate directly with the ferric heme iron, but this is not seen for the meta or ortho isomers. The π-cation interaction of the naphthalene moiety and Arg 108 residue may also assist in stabilizing substrate binding within the active-site cavity. The type II substrate binding affinity is determined by the combination of steric, electrostatic, and hydrophobicity factors; meanwhile, it is enhanced by the strength of lone pair electrons coordination with the heme iron. PMID:19053752

  17. Flexible licensing

    OpenAIRE

    Martyn Jansen

    2012-01-01

    The case is presented for a more flexible approach to licensing online library resources. Today's distributed education environment creates pressure for UK higher and further education institutions (HEI/FEIs) to form partnerships and to develop educational products and roll them out across the globe. Online library resources are a key component of distributed education and yet existing licensing agreements struggle to keep pace with the increasing range of users and purposes for which they ar...

  18. Licensing in an International Market

    Science.gov (United States)

    Ferreira, Fernanda A.

    2008-09-01

    We study the effects of entry of a foreign firm on domestic welfare in the presence of licensing, when the entrant is technologically superior to the incumbent. We show that foreign entry increases domestic welfare for sufficiently large technological differences between the firms under both fixed-fee licensing and royalty licensing.

  19. 3D QSAR Studies of DAMNI Analogs as Possible Non-nucleoside Reverse Transcriptase Inhibitors

    Directory of Open Access Journals (Sweden)

    S. Ganguly

    2008-01-01

    Full Text Available The non-nucleoside inhibitors of HIV-1-reverse transcriptase (NNRTIs are an important class of drugs employed in antiviral therapy. Recently, a novel family of NNRTIs commonly referred to as 1-[2-diarylmethoxy] ethyl 2-methyl-5-nitroimidazoles (DAMNI derivatives have been discovered. The 3D-QSAR studies on DAMNI derivatives as NNRTIs was performed by comparative molecular field analysis (CoMFA and comparative molecular similarity indices analysis (CoMSIA methods to determine the factors required for the activity of these compounds. The global minimum energy conformer of the template molecule 15, the most active molecule of the series, was obtained by simulated annealing method and used to build the structures of the molecules in the dataset. The combination of steric and electrostatic fields in CoMSIA gave the best results with cross-validated and conventional correlation coefficients of 0.654 and 0.928 respectively. The predictive ability of CoMFA and CoMSIA were determined using a test set of ten DAMNI derivatives giving predictive correlation coefficients of 0.92 and 0.98 respectively indicating good predictive power. Further, the robustness of the models was verified by bootstrapping analysis. The information obtained from CoMFA and CoMSIA 3D contour maps may be of utility in the design of more potent DAMNI analogs as NNRTIs in future.

  20. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs.

    Science.gov (United States)

    Taha, Muhammad; Ismail, Nor Hadiani; Imran, Syahrul; Rahim, Fazal; Wadood, Abdul; Khan, Huma; Ullah, Hayat; Salar, Uzma; Khan, Khalid Mohammed

    2016-10-01

    Hybrid bisindole-thiosemicarbazides analogs (1-18) were synthesized and screened for β-glucuronidase activity. All compounds showed varied degree of β-glucuronidase inhibitory potential when compared with standard d-saccharic acid 1,4-lactone (IC50=48.4±1.25μM). Compounds 4, 7, 9, 6, 5, 12, 17 and 18 showed exceptional β-glucuronidase inhibition with IC50 values ranging from 0.1 to 5.7μM. Compounds 1, 3, 8, 16, 13, 2 and 14 also showed better activities than standard with IC50 values ranging from 7.12 to 15.0μM. The remaining compounds 10, 11, and 15 showed good inhibitory potential with IC50 values 33.2±0.75, 21.4±0.30 and 28.12±0.25μM respectively. Molecular docking studies were carried out to confirm the binding interaction of the compounds. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Analogical Reasoning and Computer Programming.

    Science.gov (United States)

    Clement, Catherine A.; And Others

    1986-01-01

    A study of correlations between analogical reasoning and Logo programming mastery among female high school students related the results of pretests of analogical reasoning to posttests of programming mastery. A significant correlation was found between analogical reasoning and the ability to write subprocedures for use in several different…

  2. Echo Source Discrimination in Airborne Radar Sounding Data for Mars Analog Studies, Dry Valleys, Antarctica

    Science.gov (United States)

    Holt, J. W.; Blankenship, D. D.; Peters, M. E.; Kempf, S. D.; Morse, D. L.; Williams, B. J.

    2003-01-01

    The recent identification of features on Mars exhibiting morphologies consistent with ice/rock mixtures, near-surface ice bodies and near-surface liquid water [1,2], and the importance of such features to the search for water on Mars, highlights the need for appropriate terrestrial analogs in order to prepare for upcoming radar missions targeting these and other water-related features. Climatic, hydrological, and geological conditions in the McMurdo Dry Valleys of Antarctica are analogous in many ways to those on Mars, and a number of ice-related features in the Dry Valleys may have direct morphologic and compositional counterparts on Mars.

  3. Cyber Analogies

    Science.gov (United States)

    2014-02-28

    strategic thinking about cy- berwar reflects an awareness that this duality applies to the virtual domain as well. The history of air campaigns over the...life sciences he iden- tifies analogies in the realms of biodiversity and herd immunity . And then he flips the (seemingly unusable) notion of economic...suggests that diver- sity of cyber systems makes the defense as weak as its weakest component. 30. Herd Immunity If a sufficient proportion of the

  4. Study of the interaction between bovine hemoglobin and analogs of biphenyldicarboxylate by spectrofluorimetry

    International Nuclear Information System (INIS)

    Wang, Ruiyong; Yin, Yujing; Wang, Ruiqiang; Xie, Yuanzhe; Ge, Baoyu; Li, Zhigang; Li, Zhen; Shi, Jie; Chang, Junbiao

    2013-01-01

    The interaction between bovine hemoglobin and analogs of Biphenyldicarboxylate was investigated by fluorescence, synchronous fluorescence, ultraviolet–vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra at pH 7.40. The quenching mechanism and binding constants were determined by the quenching of bovine hemoglobin fluorescence in presence of analogs. Results showed that the nature of the quenching was of static type. Both the van der Waals and hydrogen bonding played a major role in stabilizing the complex. The distance between donor and acceptors was obtained to be 2.11–2.25 nm according to Förster's theory. The influence of analogs on the conformation of bovine hemoglobin was investigated. -- Highlights: • The interactions between bovine hemoglobin and analogs of DDB have been investigated. • Results reveal that DDB has the strongest affinity for hemoglobin among four compounds. • The van der Waals and hydrogen bonding play major role in the binding process. • The influence of molecular structure on the binding aspects has been investigated

  5. In vitro and In vivo Studies on Stilbene Analogs as Potential Treatment Agents for Colon Cancer

    Science.gov (United States)

    Based upon the potential of resveratrol as a cancer chemopreventive agent, 27 stilbenes analogs were synthesized and tested against colon cancer cell line HT-29. Among these compounds, amino derivative (Z)-4-(3,5-dimethoxystyryl) aniline (4), (Z)-methyl 4-(3,5-dimethoxystyryl) benzoate (6) and (Z)-1...

  6. Hydrogen/deuterium exchange of phenylalanine analogs studied with infrared multiple photon dissociation

    NARCIS (Netherlands)

    Contreras, C. S.; Polfer, N. C.; Chung, A. C.; Oomens, J.; Eyler, J. R.

    2010-01-01

    Phenylalanine analogs were subjected to hydrogen/deuterium exchange (HDX) in both solution and the gas phase, and gas-phase infrared multiple photon dissociation spectra were obtained for each of the species. For sodium cation-attached N-acetylphenylalanine, gas-phase HDX took place at only one

  7. How We Used NASA Lunar Set in Planetary Material Science Analog Studies on Lunar Basalts and Breccias with Industrial Materials of Steels and Ceramics

    Science.gov (United States)

    Berczi, S.; Cech, V.; Jozsa, S.; Szakmany, G.; Fabriczy, A.; Foldi, T.; Varga, T.

    2005-01-01

    Analog studies play important role in space materials education. Various aspects of analogies are used in our courses. In this year two main rock types of NASA Lunar Set were used in analog studies in respect of processes and textures with selected industrial material samples. For breccias and basalts on the lunar side, ceramics and steels were found as analogs on the industrial side. Their processing steps were identified on the basis of their textures both in lunar and in industrial groups of materials.

  8. A Computational Study on Thiourea Analogs as Potent MK-2 Inhibitors

    Science.gov (United States)

    Hao, Ming; Ren, Hong; Luo, Fang; Zhang, Shuwei; Qiu, Jieshan; Ji, Mingjuan; Si, Hongzong; Li, Guohui

    2012-01-01

    Mitogen-activated protein kinase-activated protein kinase 2 (MK-2) has been identified as a drug target for the treatment of inflammatory diseases. Currently, a series of thiourea analogs as potent MK-2 inhibitors were studied using comprehensive computational methods by 3D-QSAR, molecular docking and molecular dynamics simulations for a further improvement in activities. The optimal 3D models exhibit high statistical significance of the results, especially for the CoMFA results with r2ncv, q2 values of 0.974, 0.536 for the internal validation, and r2pred, r2m values of 0.910, 0.723 for the external validation and Roy’s index, respectively. In addition, more rigorous validation criteria suggested by Tropsha were also employed to check the built models. Graphic representation of the results, as contoured 3D coefficient plots, also provides a clue to the reasonable modification of molecules: (i) The substituent with a bulky size and electron-rich group at the C5 position of the pyrazine ring is required to enhance the potency; (ii) The H-bond acceptor group in the C3 position of the pyrazine ring is likely to be helpful to increase MK-2 inhibition; (iii) The small and electropositive substituent as a hydrogen bond donor of the C2 position in the oxazolone ring is favored; In addition, several important amino acid residues were also identified as playing an important role in MK-2 inhibition. The agreement between 3D-QSAR, molecular docking and molecular dynamics simulations also proves the rationality of the developed models. These results, we hope, may be helpful in designing novel and potential MK-2 inhibitors. PMID:22837679

  9. A Computational Study on Thiourea Analogs as Potent MK-2 Inhibitors

    Directory of Open Access Journals (Sweden)

    Guohui Li

    2012-06-01

    Full Text Available Mitogen-activated protein kinase-activated protein kinase 2 (MK-2 has been identified as a drug target for the treatment of inflammatory diseases. Currently, a series of thiourea analogs as potent MK-2 inhibitors were studied using comprehensive computational methods by 3D-QSAR, molecular docking and molecular dynamics simulations for a further improvement in activities. The optimal 3D models exhibit high statistical significance of the results, especially for the CoMFA results with r2ncv, q2 values of 0.974, 0.536 for the internal validation, and r2pred, r2m values of 0.910, 0.723 for the external validation and Roy’s index, respectively. In addition, more rigorous validation criteria suggested by Tropsha were also employed to check the built models. Graphic representation of the results, as contoured 3D coefficient plots, also provides a clue to the reasonable modification of molecules: (i The substituent with a bulky size and electron-rich group at the C5 position of the pyrazine ring is required to enhance the potency; (ii The H-bond acceptor group in the C3 position of the pyrazine ring is likely to be helpful to increase MK-2 inhibition; (iii The small and electropositive substituent as a hydrogen bond donor of the C2 position in the oxazolone ring is favored; In addition, several important amino acid residues were also identified as playing an important role in MK-2 inhibition. The agreement between 3D-QSAR, molecular docking and molecular dynamics simulations also proves the rationality of the developed models. These results, we hope, may be helpful in designing novel and potential MK-2 inhibitors.

  10. Flexible licensing

    Directory of Open Access Journals (Sweden)

    Martyn Jansen

    2012-07-01

    Full Text Available The case is presented for a more flexible approach to licensing online library resources. Today's distributed education environment creates pressure for UK higher and further education institutions (HEI/FEIs to form partnerships and to develop educational products and roll them out across the globe. Online library resources are a key component of distributed education and yet existing licensing agreements struggle to keep pace with the increasing range of users and purposes for which they are required. This article describes the process of developing a flexible approach to licensing and proposes a new model licence for online library resources which has the adaptability needed in this new global educational landscape. These ideas have been presented and discussed at various workshops across Eduserv's and JISC Collections' higher education and publisher communities, and further consultation is ongoing.

  11. Wounded Healers: A Multistate Study of Licensed Social Workers' Behavioral Health Problems.

    Science.gov (United States)

    Straussner, Shulamith Lala Ashenberg; Senreich, Evan; Steen, Jeffrey T

    2018-02-07

    Studies indicate that helping professionals are disproportionately affected by behavioral health problems. Among social workers, the nature and scope of these problems are understudied. This article reports the findings of a 2015 survey of 6,112 licensed social workers in 13 states regarding their problems with mental health; alcohol, tobacco, and other drugs; and gambling. To ascertain whether these problems preceded or developed during their social work careers, the periods of time when these issues were experienced were identified. Results indicate that 40.2 percent of respondents reported mental health problems before becoming social workers, increasing to 51.8 percent during their social work career, with 28 percent currently experiencing such problems. Nearly 10 percent of the sample experienced substance use problems before becoming social workers, decreasing to 7.7 percent during their career. Analyses by race or ethnicity, sex, and age identified between-group differences in the prevalence of these problems. The article concludes with a discussion of the implications for the social work profession. © 2018 National Association of Social Workers.

  12. Data Licensing

    OpenAIRE

    Ball, Alexander

    2011-01-01

    This talk is intended to help workshop participants decide how to apply a licence to their research data, and which licence would be most suitable. It covers why licensing data is important, the impact licences have on future research, and the potential pitfalls to avoid.

  13. Study of line-TFET analog performance comparing with other TFET and MOSFET architectures

    Science.gov (United States)

    Agopian, Paula Ghedini Der; Martino, João Antonio; Vandooren, Anne; Rooyackers, Rita; Simoen, Eddy; Thean, Aaron; Claeys, Cor

    2017-02-01

    In this work the Line-TFET performance is compared with MOSFET and Point-TFET devices, with different architectures (FinFET and GAA:Gate-All-Around) at both room and high temperatures. This analysis is based on the experimental basic analog parameters such as transconductance (gm), output conductance (gD) and intrinsic voltage gain (AV). Although the Line-TFETs present worse AV than the point-TFETs, when they are compared with MOSFET technology, the line-TFET shows a much better intrinsic voltage gain than both MOSFET architectures (FinFET and GAA). Besides the AV, the highest on-state current was obtained for Line-TFETs when compared with other two TFET architectures, which leads to a good compromise for analog application.

  14. Gelatins as rock analogs: A systematic study of their rheological and physical properties

    Science.gov (United States)

    Di Giuseppe, E.; Funiciello, F.; Corbi, F.; Ranalli, G.; Mojoli, G.

    2009-08-01

    In a laboratory model the behavior of the selected analog material must be properly scaled to nature. Here, we systematically investigate both rheological and physical properties of a wide range of gelatins as functions of temperature, composition, concentration, ageing and applied strain rate. Results show that gelatins' behavior changes gradually from purely elastic to visco-elasto-brittle to purely viscous (nonlinear) rheology going from the gel- to the sol-state. The rheological variability of gelatins appears promising for the potential use of these analog materials to simulate crustal and lithospheric rheological behavior. In particular, we found that pig skin 2.5 wt.% at 10 °C has the required rheological properties for a suitable experimental set-up to model crustal deformation.

  15. A Post Licensing Study of Community Effects at Two Operating Nuclear Power Plants. Final Report.

    Science.gov (United States)

    Purdy, Bruce J.; And Others

    In an effort to identify and assess the social, economic, and political effects of nuclear power plant construction and operation upon two host communities (Plymouth, Massachusetts and Waterford, Connecticut), a post-licensing review revealed that the primary impact of the nuclear power plants in both communities was an increase in the property…

  16. Has the Licensing Act 2003 affected violence rates in England and Wales? A systematic review of hospital and police studies.

    Science.gov (United States)

    Callan, Caitríona M; Boyle, Adrian A

    2017-12-05

    Violence has been declining in the UK for two decades, with most assaults being alcohol related. The Licensing Act 2003 (England and Wales) aimed to reduce alcohol-related crime, giving local authorities control over premises licensing. We performed a systematic review of original research with the primary outcome of change in violence rates since the Act's implementation, including hospital-defined and police-defined measures of violence. Our secondary outcome was temporal distribution of violence. Fifteen studies were included, which were of overall poor quality. Seven found reduced violence rates after the Act's implementation, three found increased rates and five found no significant change. A subset of nine studies analysed temporal distribution, eight finding displacement of incidents later. This is the most complete analysis to date of the effect of this Act on violence, finding a lack of reliable evidence to answer the research question, but little to suggest that the Act has markedly impacted already-declining violence rates.

  17. Licensing issues

    International Nuclear Information System (INIS)

    Roberts, J.P.; Desell, L.J.; Birch, M.L.; Berkowitz, L.; Bader, J.F.

    1992-01-01

    To provide guidance for the Department of Energy's (DOE) Civilian Radioactive Waste Management Program, the Nuclear Regulatory Commission (NRC) has issued a draft regulatory guide on the Format and Content for the License Application for the High-Level Waste Repository (FCRG). To facilitate the development of the FCRG, NRC suggested that DOE use the draft guide as the basis for preparing an annotated outline for a license application. DOE is doing so using an iterative process called the Annotated Outline Initiative. DOE;s use of the Initiative will assist in achieving the desired incorporation of actual experience in the FCRG, contribute to the development of shared interpretation and understanding of NRC regulations, and provide other important programmatic benefits described in this paper

  18. The neural basis of analogical reasoning: an event-related potential study.

    Science.gov (United States)

    Qiu, Jiang; Li, Hong; Chen, Antao; Zhang, Qinglin

    2008-10-01

    The spatiotemporal analysis of brain activation during the execution of easy analogy (EA) and difficult analogy (DA) tasks was investigated using high-density event-related brain potentials (ERPs). Results showed that reasoning tasks (schema induction) elicited a more negative ERP deflection (N500-1000) than did the baseline task (BS) between 500 and 1000 ms. Dipole source analysis of difference waves (EA-BS and DA-BS) indicated that the negative components were both localized near the left thalamus, possibly associated with the retrieval of alphabetical information. Furthermore, DA elicited a more positive ERP component (P600-1000) than did EA in the same time window. Two generators of P600-1000 were located in the medial prefrontal cortex (BA10) and the left frontal cortex (BA6) which was possibly involved in integrating information in schema abstraction. In the stage of analogy mapping, a greater negativity (N400-600) in the reasoning tasks as compared to BS was found over fronto-central scalp regions. A generator of this effect was located in the left fusiform gyrus and was possibly related to associative memory and activation of schema. Then, a greater negativity in the reasoning tasks, in comparison to BS task, developed between 900-1200 ms (LNC1) and 2000-2500 ms (LNC2). Dipole source analysis (EA-BS) localized the generator of LNC1 in the left prefrontal cortex (BA 10) which was possibly related to mapping the schema to the target problem, and the generator of LNC2 in the left prefrontal cortex (BA 9) which was possibly related to deciding whether a conclusion correctly follows from the schema.

  19. Detecting analogical resemblance without retrieving the source analogy.

    Science.gov (United States)

    Kostic, Bogdan; Cleary, Anne M; Severin, Kaye; Miller, Samuel W

    2010-06-01

    We examined whether people can detect analogical resemblance to an earlier experimental episode without being able to recall the experimental source of the analogical resemblance. We used four-word analogies (e.g., robin-nest/beaver-dam), in a variation of the recognition-without-cued-recall method (Cleary, 2004). Participants studied word pairs (e.g., robin-nest) and were shown new word pairs at test, half of which analogically related to studied word pairs (e.g., beaver-dam) and half of which did not. For each test pair, participants first attempted to recall an analogically similar pair from the study list. Then, regardless of whether successful recall occurred, participants were prompted to rate the familiarity of the test pair, which was said to indicate the likelihood that a pair that was analogically similar to the test pair had been studied. Across three experiments, participants demonstrated an ability to detect analogical resemblance without recalling the source analogy. Findings are discussed in terms of their potential relevance to the study of analogical reasoning and insight, as well as to the study of familiarity and recognition memory.

  20. Study of archaeological analogs for the validation of nuclear glass long-term behavior models

    International Nuclear Information System (INIS)

    Verney-Carron, A.

    2008-10-01

    Fractured archaeological glass blocks collected from a shipwreck discovered in the Mediterranean Sea near Embiez Island (Var) were investigated because of their morphological analogy with vitrified nuclear waste and of a known and stable environment. These glasses are fractured due to a fast cooling after they were melted (like nuclear glass) and have been altered for 1800 years in seawater. This work results in the development and the validation of a geochemical model able to simulate the alteration of a fractured archaeological glass block over 1800 years. The kinetics associated with the different mechanisms (interdiffusion and dissolution) and the thermodynamic parameters of the model were determined by leaching experiments. The model implemented in HYTEC software was used to simulate crack alteration over 1800 years. The consistency between simulated alteration thicknesses and measured data on glass blocks validate the capacity of the model to predict long-term alteration. This model is able to account for the results from the characterization of crack network and its state of alteration. The cracks in the border zone are the most altered due to a fast renewal of the leaching solution, whereas internal cracks are thin because of complex interactions between glass alteration and transport of elements in solution (influence of initial crack aperture and of the crack sealing). The lowest alteration thicknesses, as well as their variability, can be explained. The analog behavior of archaeological and nuclear glasses from leaching experiments makes possible the transposition of the model to nuclear glass in geological repository. (author)

  1. Changes of radio-technological studies in the field of medical imaging. From analogous studies to digital ones

    International Nuclear Information System (INIS)

    Shiraishi, Junji; Uchiyama, Yoshikazu; Honda, Michitaka; Ogura, Toshihiro; Kunitomo, Hiroshi; Kishimoto, Kenji; Ishii, Rie; Hara, Takeshi; Tanaka, Rie

    2014-01-01

    Eight authors briefly describe practical reviews of domestic changes in the title of their expertized field for the purpose of enlightenment. Reviews concern following studies: on the construction of medical images, on characteristics of input/output, of resolution, of noise, on whole assessment of images with noise-equivalent number of quanta/detective quantum efficiency (NEQ/DQE), with subjectivity, on computer-aided diagnosis (CAD), and on image displaying system assessment. X-ray image subtraction along with the development of CT is the origin of real-time digitalized image construction. Studies on the input/output affects the quality of images and exposure dose to patients, which have contributed to works of investigators at manufacturing and technologists on site. Then described are changes in the assessment of image by digital radiography (DR), of which basis was originally established at analogous sensitizer/film (S/F) era, of image resolution and of noise characteristic assessment, during the period from S/F to DR systems. Assessment of images with NEQ/DQE has been essentially based on the description in the 'Image Science' published in 1974 and its derived domestic educational researches; and the assessment with subjectivity involves the receiver operating characteristic (ROC), which leads to computer-aided diagnosis (CAD). Studies on image display are now changing responding to clinical and social needs. (T.T.)

  2. Structure-function studies of five natural, including catfish and dogfish, gonadotropin-releasing hormones and eight analogs on reproduction in Thai catfish (Clarias macrocephalus).

    Science.gov (United States)

    Ngamvongchon, S; Rivier, J E; Sherwood, N M

    1992-11-20

    Five distinct forms of gonadotropin-releasing hormone (GnRH) and their analogs, six of which are newly designed, were used to study reproduction in Thai catfish, Clarias macrocephalus. Determination was made for the percentage of fish that ovulated within 16-18 h; the percentage of eggs fertilized; and the percentage of larva that hatched and survived for 7 days. The results show, firstly, that natural chicken GnRH-II, which is identical with catfish GnRH-II, was significantly more effective at a dose of 300 micrograms/kg than the control injection for the induction of ovulation. Dogfish GnRH at the same dose was also significantly more effective than the control, but was not significantly different from chicken (catfish) GnRH-II for ovulation induction. The novel catfish GnRH-I, mammalian GnRH and salmon GnRH were not effective at 100, 150 or 300 micrograms/kg in Thai catfish. Secondly, 5 of 8 analogs of GnRH at a dose of 20 micrograms/kg resulted in a significantly higher percentage of ovulating fish compared with the control fish. Among these five analogs, the most effective were the two analog forms of chicken GnRH-II (D-Arg6,Pro9 NEt and D-Nal6,Pro9 NEt), followed by the salmon GnRH analog (D-Arg6,Pro9 NEt), a dogfish GnRH analog (D-Arg6,Pro9 NEt) and the mammalian GnRH analog (D-Ala6,Pro9 NEt). Not significantly different from the controls were the two catfish GnRH-I analogs and one of the dogfish (D-Nal6,Pro9 NEt) analogs. The six new analogs had not been previously tested in any animal. Thirdly, the number of fish ovulating was the same whether GnRH was administered in one or two injections.

  3. Photophysical and calorimetric studies on the binding of 9-O-substituted analogs of the plant alkaloid berberine to double stranded poly(A).

    Science.gov (United States)

    Basu, Anirban; Jaisankar, Parasuraman; Kumar, Gopinatha Suresh

    2013-08-05

    This interaction of four novel 9-O-substituted analogs of the plant alkaloid berberine with double stranded poly(A) was studied using a variety of biophysical techniques. Remarkably higher binding of two 9-O-ω-amino alkyl ether analogs compared to the two 9-O-N-aryl/arylalkyl amino carbonyl methyl berberine analogs was observed. Quantum efficiency values suggested that energy was transferred from the adenine base pairs to the analogs on binding. Ferrocyanide quenching and viscosity studies revealed the binding mode to be intercalative for these analogs. Circular dichroism studies showed that these analogs induced significant conformational changes in the secondary structure of ds poly(A). Energetics of the binding suggested that 9-O-N-aryl/arylalkyl amino carbonyl methyl berberines bound very weakly to ds poly(A). The binding of 9-O-ω-amino alkyl ether analogs was entropy dominated with a smaller but favorable enthalpic contribution to the Gibbs energy. Increasing the temperature resulted in weaker binding; the enthalpic contribution increased and the entropic contribution decreased. A small negative heat capacity change with significant enthalpy-entropy compensation established the involvement of multiple weak noncovalent interactions in the binding process. Copyright © 2013 Elsevier B.V. All rights reserved.

  4. A Study of an Architecture Design Learning Process Based on Social Learning, Course Teaching, Interaction, and Analogical Thinking

    Directory of Open Access Journals (Sweden)

    Yun-Wu Wu

    2014-01-01

    Full Text Available The students in the vocational education of architecture design in Taiwan often face many learning obstacles, such as no problem solving ability and lack of creativity. Therefore, this study used a social learning model as a learning strategy in the architecture design learning process to solve related learning difficulties. Firstly, this study used cognitive development teaching activities and a learning process based on analogical thinking and analogical reasoning to build the social learning model. Secondly, the social learning model of this study was implemented in the teaching of a required course of architecture design for 120 freshmen in China University of Technology. The questionnaire survey results were then statically analyzed and compared to measure the differences in the students’ knowledge about architecture designs before and after the teaching in this study. In this study, the social learning model is proven helpful in inspiring the students’ creativity by converting new knowledge of architecture design into schemas and hence retaining the new knowledge for future application. The social learning model can be applied in the teaching of architecture design in other schools, while more research can be conducted in the future to further confirm its feasibility to promote effective learning.

  5. Study of a conceptual nuclear energy center at Green River, Utah: licensing considerations

    Energy Technology Data Exchange (ETDEWEB)

    Dowdle, M.; Russell, R.; Zillman, D.

    1982-04-01

    This report examines the laws governing the location of a 9-unit nuclear energy center (NEC) near Green River, Utah. The time frame being considered for development of the conceptual NEC is from 1995 to 2013. Accordingly, the report is forced to speculate about some aspects of the plant, its site and its construction. Most of the report examines existing legal requirements for constructing an NEC. Where pertinent, changes in the law are discussed that would affect an NEC that is to be licensed in one or two decades. In general, no insurmountable legal problems exist that would prevent an NEC from being licensed at the Green River location. Several legal requirements pose significant concerns and would have to be faced before an NEC could be built. Among the major legal constraints are radiation protection, regulatory approval of financing, access to water, and local zoning restrictions. Two other constraints that involve legal matters are the wisdom of standardization of the units and the responsibility of the NEC builder to correct socio-economic impacts on the local area.

  6. Study of a conceptual nuclear energy center at Green River, Utah: licensing considerations

    International Nuclear Information System (INIS)

    Dowdle, M.; Russell, R.; Zillman, D.

    1982-04-01

    This report examines the laws governing the location of a 9-unit nuclear energy center (NEC) near Green River, Utah. The time frame being considered for development of the conceptual NEC is from 1995 to 2013. Accordingly, the report is forced to speculate about some aspects of the plant, its site and its construction. Most of the report examines existing legal requirements for constructing an NEC. Where pertinent, changes in the law are discussed that would affect an NEC that is to be licensed in one or two decades. In general, no insurmountable legal problems exist that would prevent an NEC from being licensed at the Green River location. Several legal requirements pose significant concerns and would have to be faced before an NEC could be built. Among the major legal constraints are radiation protection, regulatory approval of financing, access to water, and local zoning restrictions. Two other constraints that involve legal matters are the wisdom of standardization of the units and the responsibility of the NEC builder to correct socio-economic impacts on the local area

  7. Here, There, and Everywhere: A Case Study of Science through Analogy, Near and Far

    Science.gov (United States)

    Watzke, M.; Arcand, K.

    2014-07-01

    Here, There, and Everywhere (HTE) is a program that consists of a series of exhibitions, posters, and supporting hands-on activities that utilize analogies in the teaching of science, engineering, and technology to provide multi-generational and family-friendly content in English and Spanish to small community centers, libraries, and under-resourced small science centers. The purpose of the program is to connect crosscutting science content (in earth, atmospheric and planetary sciences, and astrophysics) with everyday phenomena. By using different modes of content delivery (physical exhibits and handouts, interpretive stations, facilitated activities for educators, and online resources), HTE helps to demonstrate the universality of physical laws and the connection between our everyday world and the universe as a whole to members of the public who may not identify strongly with science. HTE is part of a series of so-called public science projects created and developed by the Education and Public Outreach (EPO) group at the Chandra X-ray Center (CXC). This paper will outline how HTE fits into the lineage of this particular type of science outreach that aims to engage the greater public in non-traditional venues for science learning and appreciation.

  8. Gelatins as rock analog in laboratory models: a rheological study and preliminary applications

    Science.gov (United States)

    Corbi, F.; di Giuseppe, E.; Funiciello, F.; Ranalli, G.; Faccenna, C.

    2009-12-01

    A laboratory model is a simplified scaled representation of nature. Thereby, according to ‘similarity criteria’, both rheological and physical parameters involved in the modeling must be properly scaled to natural conditions. In this work we systematically investigated the rheological and physical properties of a wide range of gelatins as functions of their temperature, composition, concentration, ageing and strain rate, in both gel- (i.e. solid) and sol-state (i.e. solution). Our results show that the complex mechanical behavior of gelatins reproduces gradually the full range of rheological behavior from purely elastic to visco-elasto-brittle to purely viscous (nonlinear) rheology going from the gel- to the sol-state. The handiness of the manipulation of the gelatins’ microstructure by calibrating the setting parameters and their resulting rheological variability appear promising for the potential use of these analog materials to simulate crustal and lithospheric rheological behavior. In particular, we found that pig skin 2.5 wt.% at 10 °C has the required rheological properties for a suitable experimental set-up to model crustal deformations.

  9. Terrestrial Analogs to Mars

    Science.gov (United States)

    Farr, T. G.; Arcone, S.; Arvidson, R. W.; Baker, V.; Barlow, N. G.; Beaty, D.; Bell, M. S.; Blankenship, D. D.; Bridges, N.; Briggs, G.; Bulmer, M.; Carsey, F.; Clifford, S. M.; Craddock, R. A.; Dickerson, P. W.; Duxbury, N.; Galford, G. L.; Garvin, J.; Grant, J.; Green, J. R.; Gregg, T. K. P.; Guinness, E.; Hansen, V. L.; Hecht, M. H.; Holt, J.; Howard, A.; Keszthelyi, L. P.; Lee, P.; Lanagan, P. D.; Lentz, R. C. F.; Leverington, D. W.; Marinangeli, L.; Moersch, J. E.; Morris-Smith, P. A.; Mouginis-Mark, P.; Olhoeft, G. R.; Ori, G. G.; Paillou, P.; Reilly, J. F., II; Rice, J. W., Jr.; Robinson, C. A.; Sheridan, M.; Snook, K.; Thomson, B. J.; Watson, K.; Williams, K.; Yoshikawa, K.

    2002-08-01

    It is well recognized that interpretations of Mars must begin with the Earth as a reference. The most successful comparisons have focused on understanding geologic processes on the Earth well enough to extrapolate to Mars' environment. Several facets of terrestrial analog studies have been pursued and are continuing. These studies include field workshops, characterization of terrestrial analog sites, instrument tests, laboratory measurements (including analysis of Martian meteorites), and computer and laboratory modeling. The combination of all these activities allows scientists to constrain the processes operating in specific terrestrial environments and extrapolate how similar processes could affect Mars. The Terrestrial Analogs for Mars Community Panel has considered the following two key questions: (1) How do terrestrial analog studies tie in to the Mars Exploration Payload Assessment Group science questions about life, past climate, and geologic evolution of Mars, and (2) How can future instrumentation be used to address these questions. The panel has considered the issues of data collection, value of field workshops, data archiving, laboratory measurements and modeling, human exploration issues, association with other areas of solar system exploration, and education and public outreach activities.

  10. Challenges of SMR licensing practices

    International Nuclear Information System (INIS)

    Soderholm, K.

    2012-01-01

    This paper aims to increase the understanding of high level Nuclear Power Plant (NPP) licensing processes in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their different licensing processes and recent actions in new NPP construction. After discussing their similarities and differences, suitable features for Small Modular Reactor licensing can be emphasized and suggested. Some of the studied licensing processes have elements that are already quite well suited for application to SMRs, but all of these different national processes can benefit from studying and implementing lessons learned from SMR specific licensing needs. The main SMR features to take into account in licensing are standardization of the design, modularity, mass production and serial construction. Modularity can be divided into two different categories: the first category is simply a single unit facility constructed of independently engineered modules (e.g., construction process for Westinghouse AP-1000 NPP) and the second is a facility structure composed of many reactor modules where modules are manufactured in factories and installed into the facility as needed (e.g., NuScale Power SMR design). Short construction schedules will not be fully benefited from if the long licensing process prolongs the commissioning and approach to full-power operation. The focus area of this study is to better understand the possibility of SMR deployment in small nuclear countries, such as Finland, which currently has four operating NPPs. The licensing process needs to be simple and clear to make SMR deployment feasible from an economical point of view. This paper uses public information and interviews with experts to establish the overview of the different licensing processes and their main steps. A high-level comparison of the licensing steps has been carried out. Certain aspects of the aviation industry licensing process have also been studied and certain

  11. Challenges of SMR licensing practices

    Energy Technology Data Exchange (ETDEWEB)

    Soderholm, K., E-mail: kristiina.soderholm@fortum.com [Fortum Power, Espoo (Finland)

    2012-12-15

    This paper aims to increase the understanding of high level Nuclear Power Plant (NPP) licensing processes in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their different licensing processes and recent actions in new NPP construction. After discussing their similarities and differences, suitable features for Small Modular Reactor licensing can be emphasized and suggested. Some of the studied licensing processes have elements that are already quite well suited for application to SMRs, but all of these different national processes can benefit from studying and implementing lessons learned from SMR specific licensing needs. The main SMR features to take into account in licensing are standardization of the design, modularity, mass production and serial construction. Modularity can be divided into two different categories: the first category is simply a single unit facility constructed of independently engineered modules (e.g., construction process for Westinghouse AP-1000 NPP) and the second is a facility structure composed of many reactor modules where modules are manufactured in factories and installed into the facility as needed (e.g., NuScale Power SMR design). Short construction schedules will not be fully benefited from if the long licensing process prolongs the commissioning and approach to full-power operation. The focus area of this study is to better understand the possibility of SMR deployment in small nuclear countries, such as Finland, which currently has four operating NPPs. The licensing process needs to be simple and clear to make SMR deployment feasible from an economical point of view. This paper uses public information and interviews with experts to establish the overview of the different licensing processes and their main steps. A high-level comparison of the licensing steps has been carried out. Certain aspects of the aviation industry licensing process have also been studied and certain

  12. Using the Transient Electromagnetic (TEM) Method for Mapping Deep Groundwater Tables in Mars Analog Environments: a Baseline Field Study.

    Science.gov (United States)

    Jernsletten, J. A.

    2004-05-01

    INTRODUCTION: The purpose of this study is to explore the use of electromagnetic geophysical techniques for mapping deep groundwater tables in Mars analog environments. In order to provide a baseline for such studies, and to evaluate the appropriateness of the Transient Electro-Magnetic (TEM) method in mapping deep groundwater tables, a field study was carried out in an area in the desert approximatelt 30 miles southwest of Tucson Arizona. The field area was chosen for its convenient logistics and access to technical support, as well as for its appropriateness as a baseline Mars analog site. DISCUSSION: The surface conditions at the site are less than ideal if the main motivation is to look for analogs for surface working conditions on Mars, due to a fairly dense cover of cacti and thorny brush. However, in a situation like in the present study, where the subsurface analog is of more interest, vegetation cover is only a logistical issue. The subsurface in the field area is quite conductive, a result of its clay-rich soil, and this may at first thought seem to make it a less than ideal location for Mars analog studies. The contrary is the case, however: In having to deal with the very conductive environment at the field area location for this baseline study, it is ensured that results and conclusions drawn from this work regarding issues such as working in a conductive environment and achieving certain depths of investigation can indeed be applied to planning field studies elsewhere. Further, the study is also designed to observe the effects of powerline noise on electromagnetic data, again presenting a very-difficult case, and further aiding in building a baseline case that is overall appropriately more difficult than most field studies will be (in terms of achieving good signal-to-noise ratios and depths of investigation). The field survey consisted of 40 in-loop TEM stations, divided into 3 lines, for 4 line-km of data. The survey was carried out by a crew of one

  13. Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study.

    Science.gov (United States)

    Lebov, Jill F; Engel, Lawrence S; Richardson, David; Hogan, Susan L; Hoppin, Jane A; Sandler, Dale P

    2016-01-01

    Experimental studies suggest a relationship between pesticide exposure and renal impairment, but epidemiological evidence is limited. We evaluated the association between exposure to 39 specific pesticides and end-stage renal disease (ESRD) incidence in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. Via linkage to the US Renal Data System, we identified 320 ESRD cases diagnosed between enrolment (1993-1997) and December 2011 among 55 580 male licensed pesticide applicators. Participants provided information on use of pesticides via self-administered questionnaires. Lifetime pesticide use was defined as the product of duration and frequency of use and then modified by an intensity factor to account for differences in pesticide application practices. Cox proportional hazards models, adjusted for age and state, were used to estimate associations between ESRD and: (1) ordinal categories of intensity-weighted lifetime use of 39 pesticides, (2) poisoning and high-level pesticide exposures and (3) pesticide exposure resulting in a medical visit or hospitalisation. Positive exposure-response trends were observed for the herbicides alachlor, atrazine, metolachlor, paraquat, and pendimethalin, and the insecticide permethrin. More than one medical visit due to pesticide use (HR=2.13; 95% CI 1.17 to 3.89) and hospitalisation due to pesticide use (HR=3.05; 95% CI 1.67 to 5.58) were significantly associated with ESRD. Our findings support an association between ESRD and chronic exposure to specific pesticides, and suggest pesticide exposures resulting in medical visits may increase the risk of ESRD. Clinicaltrials.gov NCT00352924. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  14. Licensing procedures for older drivers.

    Science.gov (United States)

    2013-09-01

    This study examined the driver licensing procedures in all 50 States as they apply to the older (65+) driver. A literature review examined reports of possible declines in older driver capabilities and the ability of a driver licensing agency to scree...

  15. Jarosite occurrence in the Deccan Volcanic Province of Kachchh, western India: Spectroscopic studies on a Martian analog locality

    Science.gov (United States)

    Bhattacharya, Satadru; Mitra, Souvik; Gupta, Saibal; Jain, Nirmala; Chauhan, Prakash; Parthasarathy, G.; Ajai

    2016-03-01

    The sulfate mineral jarosite is considered a key indicator of hydrous, acidic, and oxidizing conditions on the surface of early Mars. Here we report an analog terrestrial locality hosting jarosite from Matanumadh, Kachchh, western India, using detailed spectroscopic studies on weathered basalts of the Deccan Volcanic Province and overlying tuffaceous shales and sandstones of the Matanumadh Formation. Hyperspectral data in the visible/near-infrared (350-2500 nm) to midinfrared (4000-400 cm-1) region of the electromagnetic spectrum and X-ray diffraction patterns have been acquired on samples collected from the field to detect and characterize the hydrous sulfate and phyllosilicate phases present at the studied site. Hydrous sulfates occur in association with Al-rich phyllosilicates (kaolinite) that overlie a zone of Fe/Mg smectites in altered basalts. Jarosite is found within both saprolitic clay horizons altered from the basalt and within variegated sandstone and shale/clay units overlying the saprolite; it mostly occurs as secondary veins with or without gypsum. Jarosite is also seen as coatings on kaolinite clasts of varying shapes and sizes within the tuffaceous variegated sandstone unit. We argue that the overall geological setting of the Matanumadh area, with this unusual mineral assemblage developing within altered basalts and in the overlying sedimentary sequence, mimics the geological environment of many of the identified jarosite localities on Mars and can be considered as a Martian analog from this perspective.

  16. Conjecturing via Reconceived Classical Analogy

    Science.gov (United States)

    Lee, Kyeong-Hwa; Sriraman, Bharath

    2011-01-01

    Analogical reasoning is believed to be an efficient means of problem solving and construction of knowledge during the search for and the analysis of new mathematical objects. However, there is growing concern that despite everyday usage, learners are unable to transfer analogical reasoning to learning situations. This study aims at facilitating…

  17. Biopharmaceutical Characterization and Bioavailability Study of a Tetrazole Analog of Clofibric Acid in Rat

    Directory of Open Access Journals (Sweden)

    Nancy Vara-Gama

    2017-02-01

    Full Text Available In the current investigation, the physicochemical, biopharmaceutical and pharmacokinetic characterization of a new clofibric acid analog (Compound 1 was evaluated. Compound 1 showed affinity by lipophilic phase in 1 to 5 pH interval, indicating that this compound would be absorbed favorably in duodenum or jejunum. Also, Compound 1 possess two ionic species, first above of pH 4.43 and, the second one is present over pH 6.08. The apparent permeability in everted sac rat intestine model was 8.73 × 10−6 cm/s in duodenum and 1.62 × 10−5 cm/s in jejunum, suggesting that Compound 1 has low permeability. Elimination constant after an oral administration of 50 μg/kg in Wistar rat was 1.81 h−1, absorption constant was 3.05 h−1, Cmax was 3.57 μg/mL at 0.33 h, AUC0–α was 956.54 μ/mL·h and distribution volume was 419.4 mL. To IV administration at the same dose, ke was 1.21 h−1, Vd was 399.6 mL and AUC0–α was 747.81 μ/mL·h. No significant differences were observed between pharmacokinetic parameters at every administration route. Bioavailability evaluated was 10.4%. Compound 1 is metabolized to Compound 2 probably by enzymatic hydrolysis, and it showed a half-life of 9.24 h. With these properties, Compound 1 would be considered as a prodrug of Compound 2 with potential as an antidiabetic and anti dyslipidemic agent.

  18. The contribution of threat probability estimates to reexperiencing symptoms: a prospective analog study.

    Science.gov (United States)

    Regambal, Marci J; Alden, Lynn E

    2012-09-01

    Individuals with posttraumatic stress disorder (PTSD) are hypothesized to have a "sense of current threat." Perceived threat from the environment (i.e., external threat), can lead to overestimating the probability of the traumatic event reoccurring (Ehlers & Clark, 2000). However, it is unclear if external threat judgments are a pre-existing vulnerability for PTSD or a consequence of trauma exposure. We used trauma analog methodology to prospectively measure probability estimates of a traumatic event, and investigate how these estimates were related to cognitive processes implicated in PTSD development. 151 participants estimated the probability of being in car-accident related situations, watched a movie of a car accident victim, and then completed a measure of data-driven processing during the movie. One week later, participants re-estimated the probabilities, and completed measures of reexperiencing symptoms and symptom appraisals/reactions. Path analysis revealed that higher pre-existing probability estimates predicted greater data-driven processing which was associated with negative appraisals and responses to intrusions. Furthermore, lower pre-existing probability estimates and negative responses to intrusions were both associated with a greater change in probability estimates. Reexperiencing symptoms were predicted by negative responses to intrusions and, to a lesser degree, by greater changes in probability estimates. The undergraduate student sample may not be representative of the general public. The reexperiencing symptoms are less severe than what would be found in a trauma sample. Threat estimates present both a vulnerability and a consequence of exposure to a distressing event. Furthermore, changes in these estimates are associated with cognitive processes implicated in PTSD. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Spectral Study of Water Tracks as an Analog for Recurring Slope Lineae

    Science.gov (United States)

    Ojha, L.; Wilhelm, M. B.; Wray, J. J.

    2013-01-01

    Liquid water is a key requirement for life on Earth, and serves as an important constraint on present day habitability on Mars. Recurring Slope Lineae (RSL) are a unique phenomenon on Mars that may be formed by brine seeps. Their morphological, seasonal and temporal characteristics support this hypothesis; however, spectral evidence has been lacking. Ojha et al., 2013 recently analyzed CRISM images from all confirmed RSL in the southern mid-latitudes and equatorial regions and found no spectro-scopic evidence for water. Instead, enhanced abun-dances or distinct grain sizes of both ferric and ferrous minerals are observed at most sites. The strength of these spectral signatures changes as a function of sea-son, possibly indicating removal of a fine-grained sur-face component during RSL flow, precipitation of fer-ric oxides, and/or wetting of the substrate. Water tracks (WT) have been suggested as a terrestrial analog for RSL by Levy et al., 2011. WT are defined as dark surface features that extend downslope in a linear or branching fashion, usually oriented along the steepest local gradient, in the Dry Valleys of Antarctica. They can be 1-3 m in width and can have lengths up to 2 km. They share many morphological and seasonal characteristics with RSL including active growth during summer seasons and fading during winter. Snowmelt, ground ice melt and deliquescence by hygroscopic salts have been suggested as possible formation mechanisms for water tracks. No spectral work to date has been reported for water tracks.

  20. Understanding Licensing Behavior

    DEFF Research Database (Denmark)

    Cabaleiro, Goretti; Moreira, Solon; Reichstein, Toke

    The potential for rent dissipation has been argued to be the main cause of firms? licensing out behavior being stifled.However, this aspect has been scarcely studied empirically. We draw on rent dissipation arguments, and hypothesize that firms suffering from the not-invented-here (NIH) syndrome...

  1. Understanding Licensing Behavior

    DEFF Research Database (Denmark)

    Cabaleiro, Goretti; Moreira, Solon; Reichstein, Toke

    The potential for rent dissipation has been argued to be the main cause of firms? licensing out behavior being stifled.However, this aspect has been scarcely studied empirically. We draw on rent dissipation arguments, and hypothesize that firms suffering from the not-invented-here (NIH) syndrome,...

  2. DECISION MAKING ON STRATEGIC ENVIRONMENTAL TECHNOLOGY LICENSING: FIXED-FEE VERSUS ROYALTY LICENSING METHODS

    OpenAIRE

    MING-CHUNG CHANG; JIN-LI HU; GWO-HSHIUNG TZENG

    2009-01-01

    Because of a deterioration in the quality of the environment, this paper studies the effects of the environment and the economy on environmental technology licensing in a homogeneous Cournot duopoly model in order to reduce environmental pollution and hence improve social welfare. To this end, two licensing methods — namely, a fixed-fee licensing method and a royalty licensing method — are compared. It is found that a high emission tax rate induces the innovator to not license the environment...

  3. The evolution of the national licensing system of health care professionals: a qualitative descriptive case study in Lao People's Democratic Republic.

    Science.gov (United States)

    Sonoda, Miwa; Syhavong, Bounkong; Vongsamphanh, Chanphomma; Phoutsavath, Phisith; Inthapanith, Phengdy; Rotem, Arie; Fujita, Noriko

    2017-08-07

    The introduction of a systematic framework for the licensing of health care professions, which is a crucial step in ensuring the quality of human resources for health (HRH), is still evolving in Lao People's Democraic Republic. The aim of this study was to review and document the evolution of Lao HRH policies and the development of its national licensing system. A qualitative descriptive case study methodology was applied to document and describe how Lao People's Democratic Republic laid the foundation for the development of a licensing system. The results demonstrate that Lao People's Democratic Republic is currently in the process of transitioning the focus of its HRH policies from the quantity and deployment of services to remote areas to improvements in the quality of services. The key events in the process of developing the licensing system are as follows: (1) the systematic development of relevant policies and legislation, (2) the establishment of responsible organizations and the assignment of responsible leaders, (3) the acceleration of development efforts in response to the Association of Southeast Asian Nations Mutual Recognition Arrangement for standard qualifications, (4) the strengthening of educational systems for fostering competent health care professionals, (5) the introduction of a 3-year compulsory service component in rural areas for newly recruited government servants, and (6) the introduction of a requirement to obtain a professional health care certificate to work in a private hospital. The Lao Ministry of Health (MOH) has endorsed a specific strategy for licensing to realize this system. The need for licensing systems has increased in recent years due to regional economic integration and a shift in policy toward achieving universal health coverage. A national licensing system would be a significant milestone in health system development, helping to ensure the competency of health care professionals by means of a national examination

  4. License Agreements concerning trademarks

    OpenAIRE

    Dráb, Ladislav

    2014-01-01

    The thesis deals with license agreements in relation to trademarks, specially the trademark license agreement. The thesis contains in its theoretical interpretation of the concept and sources of the license agreement. There are also analyzed various types of license agreements, including modifying the license agreement in the new Civil Code, and related types of contracts as a franchising or merchandising. Another interpretation is more concerned with trademark and trademark license agreement...

  5. 2015 Business Licenses

    Data.gov (United States)

    City of Jackson, Mississippi — This data displays all business license information for the year of 2015. This information details license classifications and status. This information will updated...

  6. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  7. Licensed Healthcare Facilities

    Data.gov (United States)

    California Natural Resource Agency — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  8. Preliminary Study on the Establishment of Regulatory Infrastructure for a Commercial SMART Licensing

    Energy Technology Data Exchange (ETDEWEB)

    Yune, Young Gill; Roh, Kyung Wan; Kang, Dong Gu; Kim, Hho Jung; Jo, Jong Chull [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2007-10-15

    The SMART, an integral type of PWR with the capacity of 330MWth, has been developed for multi-purposes such as seawater desalination, ship propulsion, and district heating in Korea since early 1990s. The basic design of the SMART had been completed in 2002. For the demonstration of the safety and performance of the SMART, a project to construct a 1/5 scaled-down prototype reactor with capacity of 65MWth, called as SMART-P(SMART Pilot Plant), has been performed from 2002 to 2006. However, in 2006, the project to construct the SMART-P was replaced with a preliminary project to develop a commercial SMART in order to advance commercialization of the SMART. Since the SMART is the first commercial reactor adopting the integral design concept and new system/components such as passive residual heat removal system, canned motor pump, and helical tube steam generator in Korea, some verification tests need to be performed to demonstrate the safety and performance of the SMART. Also, since several new design computer codes that have not yet been confirmed by the regulatory body are expected to be used in the design, some validation tests should be performed to demonstrate their applicability for important accident phenomena. In order to carry out the SMART development project satisfactorily and to prevent any undesirable delay of licensing process, it is necessary to establish a well-planned verification test program in advance through the early identification of the scope and items of the verification tests. Also, the issues for which either policy decision-makings or detailed technical evaluations are needed should be identified in an early stage of design, and the regulatory positions for the issues should be provided either timely or in advance. Advance identification of regulatory requirements/guides to be amended or newly developed enables to provide regulatory directions for such items in the early stage of design. The objective of this paper is to introduce the current

  9. Exploring trade-offs between carbon storage, yield and biodiversity in analog forestry. A case study in the Peruvian Amazon

    Science.gov (United States)

    Recanati, F.; Saini, M.; Guariso, G.; Melia, P.

    2016-12-01

    Creation and management of agro-ecosystems can considerably influence the greenhouse gas exchange between terrestrial ecosystems and atmosphere. This is especially evident for tropical areas, where the expansion of agricultural lands for monoculture is among the main causes of deforestation and consequent CO2 emissions. In these contexts, agro-ecological approaches, such as analog forestry, seem promising alternatives to intensive ones. Analog forestry is usually created for reforestation purposes through the combination of ecological succession and architecture of natural forests (i.e., inclusion of species from shrubs to higher trees). Besides provisioning a variety of food and medicinal products, they provide high levels of biodiversity (compared to other agricultural practices) and important ecosystem services, like carbon storage. Given the complexity of such agro-ecosystems, this study aims to estimate the quantity of carbon that can be stored in an analog forest as a function of its species composition. Consequently, trade-offs between performances in terms of carbon storage, productivity and biodiversity are explored. The analysis focuses on the Peruvian region of Madre de Dios, where native forest and its biodiversity is threatened by intensive agriculture. To quantify plant above- and belowground biomass and the related carbon content, we feed appropriate allometric models with plant morphological information gathered in the field. Relying on our database of productive plant species suitable for the region, we formulate an optimization problem aimed at the selection of plant population under different constraint systems. The latter are defined according to possible farmers' preferences (e.g., average profitability or multi-functionality). The analysis refers to the farm-scale and is performed over medium-term horizon (i.e., 40 years), in order to take into account important plant dynamics (species growth and the evolution of shade interaction

  10. Science Teachers' Analogical Reasoning

    Science.gov (United States)

    Mozzer, Nilmara Braga; Justi, Rosária

    2013-08-01

    Analogies can play a relevant role in students' learning. However, for the effective use of analogies, teachers should not only have a well-prepared repertoire of validated analogies, which could serve as bridges between the students' prior knowledge and the scientific knowledge they desire them to understand, but also know how to introduce analogies in their lessons. Both aspects have been discussed in the literature in the last few decades. However, almost nothing is known about how teachers draw their own analogies for instructional purposes or, in other words, about how they reason analogically when planning and conducting teaching. This is the focus of this paper. Six secondary teachers were individually interviewed; the aim was to characterize how they perform each of the analogical reasoning subprocesses, as well as to identify their views on analogies and their use in science teaching. The results were analyzed by considering elements of both theories about analogical reasoning: the structural mapping proposed by Gentner and the analogical mechanism described by Vosniadou. A comprehensive discussion of our results makes it evident that teachers' content knowledge on scientific topics and on analogies as well as their pedagogical content knowledge on the use of analogies influence all their analogical reasoning subprocesses. Our results also point to the need for improving teachers' knowledge about analogies and their ability to perform analogical reasoning.

  11. Antarctic analogs for Enceladus

    Science.gov (United States)

    Murray, A. E.; Andersen, D. T.; McKay, C. P.

    2014-12-01

    Enceladus is a new world for Astrobiology. The Cassini discovery of the icy plume emanating from the South Polar region indicates an active world, where detection of water, organics, sodium, and nano-particle silica in the plume strongly suggests that the source is a subsurface salty ocean reservoir. Recent gravity data from Cassini confirms the presence of a regional sea extending north to 50°S. An ocean habitat under a thick ice cover is perhaps a recurring theme in the Outer Solar System, but what makes Enceladus unique is that the plume jetting out into space is carrying samples of this ocean. Therefore, through the study of Enceladus' plumes we can gain new insights not only of a possible habitable world in the Solar Systems, but also about the formation and evolution of other icy-satellites. Cassini has been able to fly through this plume - effectively sampling the ocean. It is time to plan for future missions that do more detailed analyses, possibly return samples back to Earth and search for evidence of life. To help prepare for such missions, the need for earth-based analog environments is essential for logistical, methodological (life detection) and theoretical development. We have undertaken studies of two terrestrial environments that are close analogs to Enceladus' ocean: Lake Vida and Lake Untersee - two ice-sealed Antarctic lakes that represent physical, chemical and possibly biological analogs for Enceladus. By studying the diverse biology and physical and chemical constraints to life in these two unique lakes we will begin to understand the potential habitability of Enceladus and other icy moons, including possible sources of nutrients and energy, which together with liquid water are the key ingredients for life. Analog research such as this will also enable us to develop and test new strategies to search for evidence of life on Enceladus.

  12. Molecular modeling of fentanyl analogs

    Directory of Open Access Journals (Sweden)

    LJILJANA DOSEN-MICOVIC

    2004-11-01

    Full Text Available Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper.

  13. Alcohol licensing in Scotland: a historical overview.

    Science.gov (United States)

    Nicholls, James

    2012-08-01

      This paper provides a historical overview of licensing law in Scotland. It seeks to put important contemporary policy developments into their historical context and to draw attention to key themes in licensing policy debates across the United Kingdom.   Based on a survey of statutes, commissions of enquiry and consumption and retail data, this paper draws together historical evidence to present a synopsis of Scottish licensing history.   The article focuses on Scotland, but also discusses UK-wide licensing policy over a 250-year period.   Scottish licensing has diverged from licensing in England and Wales and has addressed some historical licensing weaknesses, including problems of accountability, overprovision and systemic oversight regarding off-sales. Distinctive features of current Scottish legislation include public health protection as a statutory licensing objective; local Licensing Forums and Licensing Standards Officers; a requirement for explicit policies on the 'overprovision' of licensed premises; mandatory restrictions on price promotions in the on- and off-trades; and limitations on opening hours for off-licences.   Scotland has developed alcohol policies several times addressing long-standing licensing weaknesses throughout the United Kingdom. Some Scottish alcohol policies have later become the norm in England and Wales. © 2012 The Author, Addiction © 2012 Society for the Study of Addiction.

  14. Analog study of the power control, temperature and flow of the reactor EL4

    International Nuclear Information System (INIS)

    Boulven, J.; Chazal, G.

    1966-01-01

    This study concerns the implementing and the exact determination of the gains of the plant control loops and the knowledge of the system response during possible solicitations under normal conditions. (A.L.B.)

  15. Analogies in the microscopic behavior of superfluid and classical helium studied by neturon scattering [Analogieen in het microscopische gedrag van superfluid en klassiek helium

    NARCIS (Netherlands)

    Crevecoeur, R.M.

    1996-01-01

    In this thesis we have presented the results of a neutron scattering study of the analogies in the microscopic behavior of superfluid and classical helium. Therefore we performed both neutron-diffraction experiments to study the structure and inelastic neutron scattering experiments to study the

  16. Intuitive analog circuit design

    CERN Document Server

    Thompson, Marc

    2013-01-01

    Intuitive Analog Circuit Design outlines ways of thinking about analog circuits and systems that let you develop a feel for what a good, working analog circuit design should be. This book reflects author Marc Thompson's 30 years of experience designing analog and power electronics circuits and teaching graduate-level analog circuit design, and is the ideal reference for anyone who needs a straightforward introduction to the subject. In this book, Dr. Thompson describes intuitive and ""back-of-the-envelope"" techniques for designing and analyzing analog circuits, including transistor amplifi

  17. Reflexivity: Licensing or enforcing

    OpenAIRE

    Schadler, D.

    2014-01-01

    During my research I looked at 117 languages and their anaphoric systems. The main goal of this study was to analyse reflexivization, its reasons and effects, by covering cross-linguistic data and by taking into account the variation we find on a macro- and micro-level. To be more precise, throughout this dissertation I investigated: whether we find indeed some special marking for reflexivity, i.e. licensing of reflexivity, across languages. whether there are complex reflexives that do not ha...

  18. Permission to park: A statewide study of high school parking permits to determine compliance with graduated driver licensing law.

    Science.gov (United States)

    Apanovitch, Audrey; Champany, Victoria; Wilson, Meghan; Emam, Hadeer; Ruiz, Kelly; Borrup, Kevin; Lapidus, Garry

    2015-09-01

    Motor vehicle crashes are the leading cause of fatality among teens in the United States. Beginning in the 1990s, many states enacted graduated driver licensing (GDL) systems to delay full licensure while allowing beginners to obtain experience under lower-risk conditions. Many high schools require parent and guardians of newly licensed teen drivers to complete a student parking pass application (PPA) for their son/daughter to drive, park, and transport themselves to and from school activities. The objective of this study was to describe the content of these PPAs for compliance with Connecticut's GDL law. PPAs were requested via e-mail, fax, or telephone from all Connecticut's high schools (n = 233). PPA variables included school demographics, parking rules, prohibitions and sanctions for violations, as well as reference to GDL law. Seventy-four schools were excluded because students were not allowed to park and schools did not require PPAs or declined to send us a copy of their PPAs. Of the remaining 159 schools, 122 (76.7%) sent us their PPAs. Responding schools were more likely to be suburban or rural. Most PPAs included a section on prohibitions and sanctions for driving misbehavior. Forty-three percent prohibited students from going to car during school hours, and 34% prohibited driving off campus/parking lot. Seventy percent warned of consequences for dangerous driving in parking lot, and 88% included the possibility of revocation for infractions. Only 14% had any reference to Connecticut's GDL law on their PPAs. A small percentage of Connecticut high schools include information about GDL laws on their PPAs. All states should examine their PPA content and adopt a uniform high school PPA that includes key provisions of their state's GDL laws in an effort to promote teen driving safety. Therapeutic study, level V.

  19. Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies

    Directory of Open Access Journals (Sweden)

    Hanif Shirinzadeh

    2010-03-01

    Full Text Available The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H2O2-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH–induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.

  20. On the Use of a Simple Physical System Analogy to Study Robustness Features in Animal Sciences.

    Directory of Open Access Journals (Sweden)

    Bastien Sadoul

    Full Text Available Environmental perturbations can affect the health, welfare, and fitness of animals. Being able to characterize and phenotype adaptive capacity is therefore of growing scientific concern in animal ecology and in animal production sciences. Terms borrowed from physics are commonly used to describe adaptive responses of animals facing an environmental perturbation, but no quantitative characterization of these responses has been made. Modeling the dynamic responses to an acute challenge was used in this study to facilitate the characterization of adaptive capacity and therefore robustness. A simple model based on a spring and damper was developed to simulate the dynamic responses of animals facing an acute challenge. The parameters characterizing the spring and the damper can be interpreted in terms of stiffness and resistance to the change of the system. The model was tested on physiological and behavioral responses of rainbow trout facing an acute confinement challenge. The model has proven to properly fit the different responses measured in this study and to quantitatively describe the different temporal patterns for each statistical individual in the study. It provides therefore a new way to explicitly describe, analyze and compare responses of individuals facing an acute perturbation. This study suggests that such physical models may be usefully applied to characterize robustness in many other biological systems.

  1. A comparative study on fluorescent cholesterol analogs as versatile cellular reporters

    DEFF Research Database (Denmark)

    Sezgin, Erdinc; Betul Can, Fatma; Schneider, Falk

    2016-01-01

    Cholesterol is a crucial component of cellular membranes, but knowledge of its intracellular dynamics is scarce. Thus, it is of utmost interest to develop tools for visualization of cholesterol organization and dynamics in cells and tissues. For this purpose, many studies make use of fluorescentl...

  2. Workshop on the role of natural analogs in geologic disposal of high-level nuclear waste: Proceedings

    International Nuclear Information System (INIS)

    Kovach, L.A.; Murphy, W.M.

    1995-09-01

    A Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste was held in San Antonio, Texas on July 22--25, 1991. The proceedings comprise seventeen papers submitted by participants at the workshop. A series of papers addresses the relation of natural analog studies to the regulation, performance assessment, and licensing of a geologic repository. Applications of reasoning by analogy are illustrated in papers on the role of natural analogs in studies of earthquakes, petroleum, and mineral exploration. A summary is provided of a recently completed, internationally coordinated natural analog study at Pocos de Caldas, Brazil. Papers also cover problems and applications of natural analog studies in four technical areas of nuclear waste management-. waste form and waste package, near-field processes and environment, far-field processes and environment, and volcanism and tectonics. Summaries of working group deliberations in these four technical areas provide reviews and proposals for natural analog applications. Individual papers have been cataloged separately

  3. Workshop on the role of natural analogs in geologic disposal of high-level nuclear waste: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, L.A. [ed.] [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Murphy, W.M. [ed.] [Southwest Research Inst., San Antonio, TX (United States). Center for Nuclear Waste Regulatory Analyses

    1995-09-01

    A Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste was held in San Antonio, Texas on July 22--25, 1991. The proceedings comprise seventeen papers submitted by participants at the workshop. A series of papers addresses the relation of natural analog studies to the regulation, performance assessment, and licensing of a geologic repository. Applications of reasoning by analogy are illustrated in papers on the role of natural analogs in studies of earthquakes, petroleum, and mineral exploration. A summary is provided of a recently completed, internationally coordinated natural analog study at Pocos de Caldas, Brazil. Papers also cover problems and applications of natural analog studies in four technical areas of nuclear waste management-. waste form and waste package, near-field processes and environment, far-field processes and environment, and volcanism and tectonics. Summaries of working group deliberations in these four technical areas provide reviews and proposals for natural analog applications. Individual papers have been cataloged separately.

  4. The natural analogous study of the migration of radionuclides in granite for nuclear waste disposal

    International Nuclear Information System (INIS)

    Yu Jinsheng

    1995-01-01

    Granite is one of the optimum types of surround rock for radioactive waste geological disposal. The study of natural analogues could provide very useful reference materials for selecting validating and designing site of repository in granite. The basic research substances are as follows: the fracture system and the circulation paths of the fluid, the hydrothermal alteration, the evolution of hydrothermal solution, the U, Th, REE element geochemical behaviours, the secondary mineral phases and its retention capacity for the concerned radioactive nuclides and the mass transfer modelling

  5. Automatic control of scale range applied for analog study of reactor kinetics

    International Nuclear Information System (INIS)

    Sergent, O.; Tellier, N.

    1967-01-01

    We study the response of a reactor, initially in a sub-critical state, for linear release of reactivity obeying to the following criteria, a rod drop comes in 10 seconds after the moment when the neutron power becomess equal to 10 -3 times the nominal power. We are interested in the maximum reactivity reached and in the energy released during the power excursion. For the power varying in a range from 1 to 10 10 we have used the method of automatic change scale which was installed and described in a previous report [fr

  6. Inhibition of tyrosinase by 4H-chromene analogs: Synthesis, kinetic studies, and computational analysis.

    Science.gov (United States)

    Brasil, Edikarlos M; Canavieira, Luciana M; Cardoso, Érica T C; Silva, Edilene O; Lameira, Jerônimo; Nascimento, José L M; Eifler-Lima, Vera L; Macchi, Barbarella M; Sriram, Dharmarajan; Bernhardt, Paul V; Silva, José Rogério Araújo; Williams, Craig M; Alves, Cláudio N

    2017-11-01

    Inhibition of mushroom tyrosinase was observed with synthetic dihydropyrano[3,2-b]chromenediones. Among them, DHPC04 displayed the most potent tyrosinase inhibitory activity with a K i value of 4 μm, comparable to the reference standard inhibitor kojic acid. A kinetic study suggested that these synthetic heterocyclic compounds behave as competitive inhibitors for the L-DOPA binding site of the enzyme. Furthermore, molecular modeling provided important insight into the mechanism of binding interactions with the tyrosinase copper active site. © 2017 John Wiley & Sons A/S.

  7. Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies.

    Science.gov (United States)

    Rateb, Heba S; Ahmed, Hany E A; Ahmed, Sahar; Ihmaid, Saleh; Afifi, Tarek H

    2016-01-01

    In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives ( 4a-i, 5a-f, and 6a-c ) were synthesized, fully characterized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the discovery of nine compounds 4c, 4f, 4g, 4h, 4i, 5c, 5d, 5e , and 6c (MIC range from 0.49 to 31.5 μg/mL) with potent antibacterial, antifungal, and antimycobacterial activities. Ampicillin, ciprofloxacin, amphotericin B were used as references for antibacterial and antifungal screening respectively, while isoniazid was used as a reference for antimycobacterial testing. Furthermore, molecular modeling studies were done to explore the binding mode of the most active derivatives to M. tuberculosis enoyl reductase (InhA) and DNA gyrase B. Our study showed the importance of both hydrogen bonding and hydrophobic interactions as a key interaction with the target enzymes.

  8. Study of the electron transfer in analog compounds of the Prussia blue

    International Nuclear Information System (INIS)

    Romero V, S.; Damaso C, L.F.; Reguera R, E.; Yee M, H.T.

    2006-01-01

    As answer to the necessity of the search of new nano structured materials, the present work was carried out that it studies the electron transfer in compound similar of the Prussia blue (CAAP), which are representative molecular materials, because its chromophore, magnetic, and electric properties, depend mainly on the processes that are made in their levels or orbital energy. It is known that these made up with octahedra symmetry that its are presented in form of powders, suffer processes of electron transfer when its are exposed to external stimulation by means of light (embracing the regions from the ultraviolet one until the infrared in the electromagnetic spectrum), because they are made up of mixed valency. To know that types of electronic transfers are those that are made in the study materials, 4 series of CAAP its were synthesized by the method of mixtures of aqueous solutions: M[Fe +3 CN) 6 ] 2 nH 2 O, M[Cr +3 (CN) 6 ] 2 nH 2 O, M[Mn +3 (CN) 6 ] 3 nH 2 O y M[Co +3 (CN) 6 ] 3 nH 2 O, and later on studied by means of the electron spectroscopy technique with a UV-SENSE spectrophotometer (Perkin-Elmer) in or n range of work of 250 to 1100 nm. Because to discuss the electronic structures of any compound, it is required the calculation of the energy levels, they took like reference the data tabulated by John Alexander and Harry Gray calculated by the modified theoretical approach of Wolfsberg-Helmhoz. When comparing the obtained spectra with the theoretical data, it was concludes that in the CAAP, its are carried out electronic transfers among orbital molecular metallic of the type d → d, and load transfer (TC) among orbital molecular of the ligand and metal. When being carried out a load transfer in the CAAP that initially are made up of under-spin these its are photoinduced to an excited state of high spin. In consequence it is possible to vary the interactions among the metals of transition of the CAAP and the ligands, allowing the extension of coordinated

  9. Hybrid 2D/3D-quantitative structure-activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors.

    Science.gov (United States)

    Arodola, Olayide A; Soliman, Mahmoud Es

    2018-01-01

    Cathepsin D, one of the attractive targets in the treatment of breast cancer, has been implicated in HIV neuropathogenesis with potential proteolytic effects on chemokines. Methodology/result: Diverse modeling tools were used to reveal the key structural features affecting the inhibitory activities of 78 pepstatin A analogs. Analyses were performed to investigate the stability, rationality and fluctuation of the analogs. Results showed a clear correlation between the experimental and predicted activities of the analogs as well as the variation in their activities relative to structural modifications. The insight gained from this study offers theoretical references for understanding the mechanism of action of cathepsin D and will aid in the design of more potent and clinically-relevant drugs. Graphical abstract [Formula: see text].

  10. Novel acyclonucleoside analog bearing a 1,2,4-triazole–Schiff base: Synthesis, characterization and analytical studies using square wave-adsorptive stripping voltammetry and HPLC

    OpenAIRE

    Ali F. Alghamdi; Nadjet Rezki

    2017-01-01

    New acyclonucleoside analogs tethered by a 1,2,4-triazole scaffold were synthesized through the condensation of 4-amino-5-(2-phenyleth-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (2) with benzaldehyde followed by the alkylation of the resulting Schiff base (3)with 2-bromoethanol, 3-chloropropanol and/or 3-chloropropan-1,2-diol. Voltammetric studies were carried out for the analysis of 1 × 10−6 mol L−1 of the newly synthesized acyclonucleoside analogs (4–6) using square wave-adsorptive stripp...

  11. Phosphorylation of the sarcoplasmic reticulum Ca(2+)-ATPase from ATP and ATP analogs studied by infrared spectroscopy.

    Science.gov (United States)

    Liu, Man; Barth, Andreas

    2004-11-26

    Phosphorylation of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1a) was studied with time-resolved Fourier transform infrared spectroscopy. ATP and ATP analogs (ITP, 2'- and 3'-dATP) were used to study the effect of the adenine ring and the ribose hydroxyl groups on ATPase phosphorylation. All modifications of ATP altered conformational changes and phosphorylation kinetics. The differences compared with ATP increased in the following order: 3'-dATP > ITP > 2'-dATP. Enzyme phosphorylation with ITP results in larger absorbance changes in the amide I region, indicating larger conformational changes of the Ca(2+)-ATPase. The respective absorbance changes obtained with 3'-dATP are significantly different from the others with different band positions and amplitudes in the amide I region, indicating different conformational changes of the protein backbone. ATPase phosphorylation with 3'-dATP is also much ( approximately 30 times) slower than with ATP. Our results indicate that modifications to functional groups of ATP (the ribose 2'- and 3'-OH and the amino group in the adenine ring) affect gamma-phosphate transfer to the phosphorylation site of the Ca(2+)-ATPase by changing the extent of conformational change and the phosphorylation rate. ADP binding to the ADP-sensitive phosphoenzyme (Ca(2)E1P) stabilizes the closed conformation of Ca(2)E1P.

  12. Analogy: Justification for Logic.

    Science.gov (United States)

    Sacksteder, William

    1979-01-01

    Presents and defends the thesis that it is analogy which provides justification for any logic, and for any argument to the extent that it depends on logic for justification. Analogy acquires inept support from logic, but logic acquires adroit support from analogy. (JMF)

  13. Study and achievement of a digital-analog-divider; Etude et realisation d'un diviseur-analogique-numerique

    Energy Technology Data Exchange (ETDEWEB)

    Petin, A. [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

    1969-04-01

    This apparatus is designed to give directly, in digital form, the value of the ratio Vt1/V2 two analog voltages. It consists essentially of an analog-digital coder operating by successive weighing; the comparison voltage is made proportional to the divider V2 in the coder. The input dynamics are such that the voltages Vi and V2 are all in the range -50 mV to -5 V. Each of the circuits has an input impedance of about 10 K{omega}. As for the quotient, it is a binary number given in series and parallel form; it is made up of 8 bits, this giving a change of 1/16 to 16 per jump of 1/16 in the zone where the accuracy is highest (V2 {>=} 800 mV). The time required for a division is, at best, 15 {mu}sec. During the time of calculation, the voltages V{sub 1} and V{sub 2} should not vary by more than 1 per cent and 0.5 per cent respectively. The theory of the system and the investigation of a synoptic diagram, the study of the circuits and the actual construction are presented. (author) [French] Cet appareil est destine a fournir directement sous forme numerique la valeur du rapport V1/V2 de deux tensions analogiques. Il est constitue essentiellement d'un codeur analogique-numerique fonctionnant par pesees successives dans lequel la tension de reference est rendue proportionnelle au diviseur V2. La dynamique d'entree est telle que les tensions V1 et V2 peuvent etre comprises dans l'intervalle -50 mV a -5 V. Chacune des voies presente une impedance d'entree d'environ 10 K{omega}. En ce qui concerne le quotient, c'est un nombre binaire delivre sous les formes serie et parallele ; il est compose de 8 bits, ce qui donne une variation de 1/16 a 16 par bond de 1/16 dans la zone de meilleure precision (V2 {>=} 800 mV). Le temps necessaire pour effectuer la division est au mieux de 15 {mu}s. Durant le temps de calcul les tensions V{sub 1} et V{sub 2} ne doivent pas varier respectivement de plus de 1 pour cent et 0.5 pour cent. Apres avoir etabli la

  14. Bacterial Peptide Deformylase Inhibition of Tetrazole-Substituted Biaryl Acid Analogs: Synthesis, Biological Evaluations, and Molecular Docking Study.

    Science.gov (United States)

    Khan, Firoz A Kalam; Patil, Rajendra H; Patil, Manjiri; Arote, Rohidas; Shinde, Devanand B; Sangshetti, Jaiprakash N

    2016-12-01

    The synthesis and screening of tetrazole-substituted biaryl acid analogs 7a-l as bacterial peptide deformylase (PDF) enzyme inhibitors is reported. The compounds 7e (IC 50 value = 5.50 μM) and 7g (IC 50 value = 7.25 μM) showed good PDF inhibition activity. The compounds 7e (MIC range = 10.75-11.66 μg/mL) and 7g (MIC range = 8.91-12.83 μg/mL) also showed potent antibacterial activity when compared with the standard ciprofloxacin (MIC range = 25-50 μg/mL). Thus, the active derivatives were not only potent PDF enzyme inhibitors but also efficient antibacterial agents. In order to gain more insight into the binding mode of the compounds with the PDF enzyme, the most active compounds 7e and 7g, the moderately active compound 7k, and the least active compound 7h were docked against the PDF enzyme of Escherichia coli. The docking study of the most active compounds 7e and 7g against the PDF enzyme exhibited good binding properties. Hence, we believe our synthesized compounds 7a-l could serve as reservoir for bacterial PDF inhibitor development. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Studies on the chitin/chitosan binding properties of six cuticular proteins analogous to peritrophin 3 from Bombyx mori.

    Science.gov (United States)

    Qu, M; Ren, Y; Liu, Y; Yang, Q

    2017-08-01

    Chitin deacetylation is required to make the cuticle rigid and compact through chitin chain crosslinking. Thus it is presumed that specialized proteins are required to bind deacetylated chitin chains together. However, deacetylated-chitin binding proteins have not ever been reported. In a previous work, six cuticular proteins analogous to peritrophin 3 (CPAP3s) were found to be abundant in the moulting fluid of Bombyx mori. In this study, these BmCPAP3s (BmCPAP3-A1, BmCPAP3-A2, BmCPAP3-B, BmCPAP3-C, BmCPAP3-D1 and BmCPAP3-D2) were cloned and expressed in Escherichia coli and purified using metal-chelating affinity chromatography. Their binding activities demonstrated that although all of the BmCPAP3s showed similar binding abilities toward crystalline chitin and colloidal chitin, they differed in their affinities toward partially and fully deacetylated chitin. Amongst them, BmCPAP3-D1 exhibited the highest binding activity toward deacetylated chitin. The gene expression pattern of BmCPAP3-D1 was similar to BmCPAP3-A1 and BmCPAP3-C at most stages except that it was dramatically upregulated at the beginning of the pupa to adult transition stage. This work is the first report of a chitin-binding protein, BmCPAP3-D1, which exhibits high binding affinity to deacetylated chitin. © 2017 The Royal Entomological Society.

  16. Analog and hybrid computing

    CERN Document Server

    Hyndman, D E

    2013-01-01

    Analog and Hybrid Computing focuses on the operations of analog and hybrid computers. The book first outlines the history of computing devices that influenced the creation of analog and digital computers. The types of problems to be solved on computers, computing systems, and digital computers are discussed. The text looks at the theory and operation of electronic analog computers, including linear and non-linear computing units and use of analog computers as operational amplifiers. The monograph examines the preparation of problems to be deciphered on computers. Flow diagrams, methods of ampl

  17. New Insight into the Nature of Bonding in the Dimers of Lappert’s Stannylene and Its Ge Analogs : A Quantum Mechanical Study

    NARCIS (Netherlands)

    Sedlak, R.; Stasyuk, O.A.; Fonseca Guerra, C.; Rezac, J.; Ruzicka, A.; Hobza, P

    2016-01-01

    The strength and nature of the connection in Lappert’s stannylene dimer ({Sn[CH(SiMe3)2]2}2) and its smaller analogs, simplified stannylenes, as well as similar Ge complexes were studied by means of DFT-D3 calculations, energy decomposition analysis (EDA), electrostatic potential (ESP), and natural

  18. Brand Licensing : Once you pop you can’t stop: When brand licensing goes too far

    OpenAIRE

    Dementev, Kirill; Lukyanchenko, Yuliya; Emilsson, Cecilia

    2011-01-01

    Purpose: The purpose of this study is to investigate consumer’s attitude towards licensed products in relation to the parent brand, with respect to perceived quality, likelihood to buy and associations’ transferability. Background: Brand licensing has become one of an increasingly popular ways of stretching a brand into new product categories to reach more consumers in new markets. Despite the fact that brand licensing is less risky than building a brand from scratch, the odds that licensed p...

  19. Policy Framework Paper on Business Licensing Reform and Simplification

    OpenAIRE

    International Finance Corporation; Multilateral Investment Guarantee Agency; World Bank

    2010-01-01

    This paper includes an overall introduction to the uses (and abuses) of business licenses, and to the way business licensing reforms can be organized. It also provides a broad overview and framework for licensing reforms. This paper is supported by more detailed case studies of licensing reform in particular sectors, and other guidance for facilities and field operations. This includes a d...

  20. Technology licensing in China

    DEFF Research Database (Denmark)

    Wang, Yuandi; Li-Ying, Jason; Chen, Jin

    2015-01-01

    We explore the landscape of technology licensing among Chinese entities in the period 2000–12, using a unique database on technological licensing from the State Intellectual Property Office of China. We find that: first, among Chinese licensee organizations, firms have dominated in terms of the n......We explore the landscape of technology licensing among Chinese entities in the period 2000–12, using a unique database on technological licensing from the State Intellectual Property Office of China. We find that: first, among Chinese licensee organizations, firms have dominated in terms...... of the number of licensed technologies; second, the geographical distribution of licensed technologies among the provinces has gradually reached a new quantitative balance; third, utility models are the most popular technologies to be licensed and the majority of technology licensing in China has been between...

  1. State Licenses & Permits

    Data.gov (United States)

    Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

  2. Online driver's license renewal.

    Science.gov (United States)

    2015-09-01

    The Kentucky Department of Vehicle Regulation is exploring the possibility of developing and implementing online : drivers license renewal. The objective of this project was to: 1) evaluate online drivers license and REAL ID renewal : programs ...

  3. Analogical proportions: another logical view

    Science.gov (United States)

    Prade, Henri; Richard, Gilles

    This paper investigates the logical formalization of a restricted form of analogical reasoning based on analogical proportions, i.e. statements of the form a is to b as c is to d. Starting from a naive set theoretic interpretation, we highlight the existence of two noticeable companion proportions: one states that a is to b the converse of what c is to d (reverse analogy), while the other called paralogical proportion expresses that what a and b have in common, c and d have it also. We identify the characteristic postulates of the three types of proportions and examine their consequences from an abstract viewpoint. We further study the properties of the set theoretic interpretation and of the Boolean logic interpretation, and we provide another light on the understanding of the role of permutations in the modeling of the three types of proportions. Finally, we address the use of these proportions as a basis for inference in a propositional setting, and relate it to more general schemes of analogical reasoning. The differences between analogy, reverse-analogy, and paralogy is still emphasized in a three-valued setting, which is also briefly presented.

  4. Driving Performance among Bioptic Telescope Users with Low Vision Two Years after Obtaining Their Driver's License: A Quasi-Experimental Study

    Science.gov (United States)

    Vincent, Claude; Lachance, Jean-Paul; Deaudelin, Isabelle

    2012-01-01

    This study sought to compare road safety of new drivers with low vision who have followed a specific pilot bioptic training program with other groups of drivers all matched for age and driving experience. A quasi-experimental design was used two years after drivers obtained their license. Drivers were classified in the experimental group (n = 10,…

  5. Detailed Study of the Formation of Sugar Derivatives Produced from the UV Irradiation of Astrophysical Ice Analogs

    Science.gov (United States)

    Nuevo, Michel; Cooper, George; Saunders, John; Buffo, Christina E.; Materese, Christopher K.; Sandford, Scott A.

    2018-01-01

    Carbonaceous meteorites such as Murchison contain a large variety of organic compounds of astrobiological interest such as amino acids, other amphiphilic compounds, functionalized nitrogen heterocycles (including nucleobases), functionalized polycylic aromatic hydro-carbons (including quinones), and sugar derivatives. The presence of such a broad variety of organics in meteorites strongly suggests that molecules essential to life can form abiotically under astrophysical conditions. This hypothesis is strongly supported by laboratory studies in which astrophysical ice analogs (i.e., mixtures of H2O, CO, CO2, CH3OH, CH4, NH3, etc.) are subjected to ultraviolet (UV) irradiation at low temperature (less than 15 K) to simulate cold interstellar environments. These studies have shown that the organic residues recovered at room temperature after irradiation contain organic compounds that are very similar to those found in meteorites. No systematic search for the presence of sugar derivatives in laboratory residues had been carried out until the recent detection of ribose, the sugar of RNA, as well as other sugars, sugar alcohols, and sugar acids in one residue produced from the UV irradiation of an ice mixture containing H2O, CH3OH, and NH3 at 80 K. In this work, we present a detailed study of the formation of sugar derivatives contained in organic residues that are produced from the UV irradiation of ice mixtures of different starting compositions (H2O, CH3OH, CO, CO2, and/or NH3) at less than 15 K. While the presence of sugar alcohols, sugars, and sugar acids-in some cases with up to 6 carbon atoms-could be confirmed in all these residues, their distribution was shown to vary with the composition of the starting ices. In particular, only a few ices result in the formation of sugar derivatives displaying a distribution that resembles that of meteorites, in which sugar alcohols and sugar acids are very abundant while sugars are mostly absent.

  6. Nuclear power stations licensing

    International Nuclear Information System (INIS)

    Solito, J.

    1978-04-01

    The judicial aspects of nuclear stations licensing are presented. The licensing systems of the United States, Spain, France and Federal Republic of Germany are focused. The decree n 0 60.824 from July 7 sup(th), 1967 and the following legislation which define the systematic and area of competence in nuclear stations licensing are analysed [pt

  7. Licensing and Patent Protection

    OpenAIRE

    Aniruddha Bagchi; Arijit Mukherjee

    2010-01-01

    We show the impact of technology licensing on optimal patent policy. Strong patent protection that eliminates imitation may not be the equilibrium outcome in the presence of licensing. Depending on the cost of innovation, licensing may either increase or reduce the strength of the patent protection.

  8. Disproportionate sales of crime guns among licensed handgun retailers in the United States: a case-control study.

    Science.gov (United States)

    Wintemute, G J

    2009-10-01

    To determine risk factors among licensed firearm retailers for disproportionate sales of handguns that are later subjected to ownership tracing, generally after use in crime. Case-control; the study period was 1998-2003. Cases were all eligible firearm retailers whose handguns were later traced at a rate that significantly (por= 50 handguns annually during the study period. Status as a case. Odds ratios were used to measure relative risk. In multivariate analyses, cases had larger sales volumes, sold inexpensive handguns more often, had a higher percentage of sales denied because the prospective purchasers were prohibited from owning firearms, and were more likely to be in an urban area, in or near a city with a policy of tracing all recovered crime guns. The effects of several risk factors, including status as a pawnbroker and sales to law enforcement personnel, appeared to be mediated by purchaser characteristics for which denied sales are a proxy measure. A number of factors-most of them characteristics of the retailers or of their handgun purchasers, and most of them available in existing data-were linked to disproportionate sales of handguns that are later used in crime.

  9. An observational study of agreement between percentage pain reduction calculated from visual analog or numerical rating scales versus that reported by parturients during labor epidural analgesia.

    Science.gov (United States)

    Pratici, E; Nebout, S; Merbai, N; Filippova, J; Hajage, D; Keita, H

    2017-05-01

    This study aimed to determine the level of agreement between calculated percentage pain reduction, derived from visual analog or numerical rating scales, and patient-reported percentage pain reduction in patients having labor epidural analgesia. In a prospective observational study, parturients were asked to rate their pain intensity on a visual analog scale and numerical rating scale, before and 30min after initiation of epidural analgesia. The percentage pain reduction 30min after epidural analgesia was calculated by the formula: 100×(score before epidural analgesia-score 30min after epidural analgesia)/score before epidural analgesia. To evaluate agreement between calculated percentage pain reduction and patient-reported percentage pain reduction, we computed the concordance correlation coefficient and performed Bland-Altman analysis. Ninety-seven women in labor were enrolled in the study, most of whom were nulliparous, with a singleton fetus and in spontaneous labor. The concordance correlation coefficient with patient-reported percentage pain reduction was 0.76 (95% CI 0.6 to 0.8) and 0.77 (95% CI 0.6 to 0.8) for the visual analog and numerical rating scale, respectively. The Bland-Altman mean difference between calculated percentage pain reduction and patient-reported percentage pain reduction for the visual analog and numerical rating scales was -2.0% (limits of agreement at 29.8%) and 0 (limits of agreement at 28.2%), respectively. The agreement between calculated percentage pain reduction from a visual analog or numerical rating scale and patient-reported percentage pain reduction in the context of labor epidural analgesia was moderate. The difference could range up to 30%. Patient-reported percentage pain reduction has advantages as a measurement tool for assessing pain management for childbirth but differences compared with other assessment methods should be taken into account. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. D-seco-Vitamin D analogs having reversed configurations at C-13 and C-14: Synthesis, docking studies and biological evaluation.

    Science.gov (United States)

    Szybinski, Marcin; Sokolowska, Katarzyna; Sicinski, Rafal R; Plum, Lori A; DeLuca, Hector F

    2017-10-01

    Prompted by results of molecular modeling performed on the seco-d-ring-vitamins D, we turned our attention to such analogs, having reversed configurations at C-13 and C-14, as the next goals of our studies on the structure-activity relationship for vitamin D compounds. First, we developed an efficient total synthesis of the "upper" C/seco-d-ring fragment with a 7-carbon side chain. Then, we coupled it with A-ring fragments using Sonogashira or Wittig-Horner protocol, providing the targeted D-seco analogs of 1α,25-dihydroxyvitamin D 3 and 1α,25-dihydroxy-19-norvitamin D 3 possessing a vinyl substituent at C-14 and a double bond between C-17 and C-20. The affinities of the synthesized vitamin D analogs to the full-length recombinant rat VDR were examined, as well as their differentiating and transcriptional activities. In these in vitro tests, they were significantly less active compared to 1α,25-(OH) 2 D 3 . Moreover, it was established that the analogs tested in vivo in rats showed no calcemic potency. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1987-05-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes

  12. Nuclear reactor operator licensing

    International Nuclear Information System (INIS)

    Bursey, R.J.

    1978-01-01

    The Atomic Energy Act of 1954, which was amended in 1974 by the Energy Reorganization Act, established the requirement that individuals who had the responsibility of operating the reactors in nuclear power plants must be licensed. Section 107 of the act states ''the Commission shall (1) prescribe uniform conditions for licensing individuals; (2) determine the qualifications of such individuals; and (3) issue licenses to such individuals in such form as the Commission may prescribe.'' The article discusses the types of licenses, the selection and training of individuals, and the administration of the Nuclear Regulatory Commission licensing examinations

  13. The effect of stricter licensing on road traffic injury events involving 15 to 17-year-old moped drivers in Sweden: A time series intervention study.

    Science.gov (United States)

    Bonander, Carl; Andersson, Ragnar; Nilson, Finn

    2015-10-01

    This study aimed to evaluate and quantify the effect of the introduction of the AM driving license on non-fatal moped-related injuries in Sweden. With the introduction of the new license category in October 2009, prospective moped drivers are now required to pass a mandatory theory test following a practical and theoretical course. In addition, obtaining a license to operate a moped is now considerably more costly. Time series intervention analysis on monthly aggregated injury data (1st Jan 2007-31st Dec 2013) was performed using generalized additive models for location, shape and scale (GAMLSS) to quantify the effect size on injury events involving teenage (15-17 years) moped drivers, while controlling for trend and seasonality. Exposure was adjusted for by using the number of registered mopeds in traffic as a proxy. The introduction of AM license was associated with a 41% reduction in the rate of injury events involving 15-year-old moped drivers (IRR 0.59 [95% CI: 0.48-0.72]), and a 39% and 36% decrease in those involving 16-year-old (IRR 0.61 [95% CI: 0.48-0.79]) and 17-year-old drivers (IRR 0.64 [95% CI: 0.46-0.90]), respectively. The effect in the 15-year-old stratum was decreased roughly by half after adjusting for exposure, but remained significant, and the corresponding estimates in the other age groups did not change noticeably. This study provides quasi-experimental evidence of an effect on non-fatal moped-related injuries as a result of stricter licensing rules. Only part of the effect could be explained by a reduction in the number of mopeds in traffic, indicating that other mechanisms must be studied to fully understand the cause of the reduction in injuries. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Producing and Recognizing Analogical Relations

    Science.gov (United States)

    Lipkens, Regina; Hayes, Steven C

    2009-01-01

    Analogical reasoning is an important component of intelligent behavior, and a key test of any approach to human language and cognition. Only a limited amount of empirical work has been conducted from a behavior analytic point of view, most of that within Relational Frame Theory (RFT), which views analogy as a matter of deriving relations among relations. The present series of four studies expands previous work by exploring the applicability of this model of analogy to topography-based rather than merely selection-based responses and by extending the work into additional relations, including nonsymmetrical ones. In each of the four studies participants pretrained in contextual control over nonarbitrary stimulus relations of sameness and opposition, or of sameness, smaller than, and larger than, learned arbitrary stimulus relations in the presence of these relational cues and derived analogies involving directly trained relations and derived relations of mutual and combinatorial entailment, measured using a variety of productive and selection-based measures. In Experiment 1 participants successfully recognized analogies among stimulus networks containing same and opposite relations; in Experiment 2 analogy was successfully used to extend derived relations to pairs of novel stimuli; in Experiment 3 the procedure used in Experiment 1 was extended to nonsymmetrical comparative relations; in Experiment 4 the procedure used in Experiment 2 was extended to nonsymmetrical comparative relations. Although not every participant showed the effects predicted, overall the procedures occasioned relational responses consistent with an RFT account that have not yet been demonstrated in a behavior-analytic laboratory setting, including productive responding on the basis of analogies. PMID:19230515

  15. Experimental Validation of RELAP5 and TRACE5 for Licensing Studies of the Boron Injection System of Atucha II

    Directory of Open Access Journals (Sweden)

    Alejandro I. Lazarte

    2011-01-01

    Full Text Available This paper presents an experimental validation of RELAP5 and TRACE5 for licensing studies of the Atucha II-PHWR nuclear power plant. A scaled experimental facility, representing the boron injection system of Atucha II, was built. The system has a fundamental importance for loss of coolant accidents (LOCA and anticipated transients without scram (ATWS. The experiment consists of the discharge of a tank that represents the boron tank filled with air or a mixture of air-water onto a discharge tank that represents the moderator tank. Both tanks are connected by a pipe which includes a valve and an orifice plate to model the pressure losses due to the fittings in the real system. The pressure and water level measured in the tanks are compared with the RELAP5 and TRACE5 predictions. The codes predict the pressure in the tanks accurately. However, both codes overpredict the heat transfer in the boron tank air-water interface which produces a greater expansion of the air which leads to a small discrepancy in the boron tank level prediction.

  16. Analog circuit design

    CERN Document Server

    Dobkin, Bob

    2012-01-01

    Analog circuit and system design today is more essential than ever before. With the growth of digital systems, wireless communications, complex industrial and automotive systems, designers are being challenged to develop sophisticated analog solutions. This comprehensive source book of circuit design solutions aids engineers with elegant and practical design techniques that focus on common analog challenges. The book's in-depth application examples provide insight into circuit design and application solutions that you can apply in today's demanding designs. <

  17. Quality of sunglasses available in the Iranian market; a study with emphasis on sellers′ license

    Directory of Open Access Journals (Sweden)

    Nooshin Bazzazi

    2015-01-01

    Full Text Available Context: Sunglasses should follow minimum requirements to sufficiently protect eyes. It is not known whether all items obtainable from the market are appropriately designed. Aims: To compare ultraviolet (UV-protective properties of commercially available sunglasses obtained from authorized and unauthorized Iranian sellers. Settings and Study Design: An analytic-descriptive study performed in a metropolitan area (Tehran. Materials and Methods: Using a UV-visible standard spectrophotometer, the percentage transmittance was scanned between 280 and 400 nm in 348 pairs of nonprescription sunglasses (price range: 20-80 US$ obtained anonymously and randomly from authorized (permitted by the Ministry of Health, 189 pairs and unauthorized (159 pairs sellers in the Iranian capital city, Tehran. The Australian/New Zealand Standard (AS/NZS and the American National Standards Institute [ANSI] standards were followed. Statistical Analysis: Chi-square test, independent samples t-test or Mann-Whitney U-test. Results UV-protective properties of the sunglasses obtained from authorized sellers complied with AS/NZS and ANSI guidelines in 92.6% and 95.2% of items, respectively. The corresponding rates for sunglasses obtained from unauthorized sellers were 0% and 8.2%, respectively (P < 0.001 for both. The rate of defective polarizing capability of lenses was 27.4% in sunglasses obtained from authorized sellers versus 90.4% in sunglasses obtained from unauthorized sellers (P < 0.001. Neither brand nor price played significant contributions to UV protection/lens polarizing capability of sunglasses obtained from authorized sellers. Conclusions: Sunglasses provided by unauthorized sellers are alarmingly unreliable and could be potentially hazardous for the eye. Brand and price do not guarantee optimal protection against UV radiation or polarizing performance of the lens.

  18. From analog to digital

    CERN Document Server

    Belleman, J

    2008-01-01

    Analog-to-digital conversion and its reverse, digital-to-analog conversion, are ubiquitous in all modern electronics, from instrumentation and telecommunication equipment to computers and entertainment. We shall explore the consequences of converting signals between the analog and digital domains and give an overview of the internal architecture and operation of a number of converter types. The importance of analog input and clock signal integrity will be explained and methods to prevent or mitigate the effects of interference will be shown. Examples will be drawn from several manufacturers' datasheets.

  19. Learning-by-Licensing: How Chinese Firms Benefit From Licensing-In Technologies

    DEFF Research Database (Denmark)

    Wang, Yuandi; Roijakkers, N.; Vanhaverbeke, W.

    2012-01-01

    This paper explores how interfirm variations in their in-licensed technology portfolios influence subsequent innovation performance. Existing studies mainly assume licensed technologies are homogeneously accessible to firms, and a prevailing explanation as to why firms vary in their innovation...... performance lies in differences of absorptive capacity. In this study, we intend to relax this assumption and use data about 186 Chinese indigenous firms to investigate how differences in in-licensing portfolios lead to different effects on innovation performance. We find that firms benefit from prior in-licensing...... technologies and the result is related to four dimensions of their licensing portfolios. We find that 1) the scale of firms' technology in-licensing has an inverted-U relationship with their subsequent innovation performance; 2) firms that license-in foreign technologies tend to outperform those...

  20. 29 Has the licensing ACT 2003 affected levels of violence in England and Wales? A systematic review of hospital and police studies.

    Science.gov (United States)

    Callan, Caitríona; Boyle, Adrian

    2017-12-01

    Population-level legislation has been implemented in many countries to try and address alcohol misuse and related harms, including assault. Most violent incidents in the UK are alcohol-related, with alcohol misuse accounting for a substantial proportion of Accident and Emergency Department attendances. The Licensing Act 2003 aimed to reduce alcohol-related crime and disorder by abolishing set closing times and giving local authorities control over premises licensing in England and Wales. Concerns were raised, however, that greater availability of alcohol would lead to increased consumption and violence. This review examines primary research from hospital and police settings to evaluate whether the implementation of the Act in 2005 reduced or increased violence rates in England and Wales. We performed an inclusive systematic review of the major biomedical databases. We included original research that evaluated changes in violence rates before and after the implementation of the Licensing Act, including hospital- and police- defined measures for this primary outcome. Our secondary outcome was whether there was change in temporal distribution of violent incidents after implementation of the Act. We identified 184 studies. 15 studies were included. The evidence was of overall poor quality, with the majority of included studies being uncontrolled before-after studies. 8 of these studies were conducted in the hospital setting, and 7 were from the police setting. Overall, 7 studies found reduced violence rates after implementation of the Licensing Act, 3 found increased rates, and 5 found no significant change. A subset of 9 papers analysed temporal distribution of violent incidents, 8 finding evidence of temporal displacement of assaults further into the early hours of the morning. This is the most complete analysis to date of the effects of the Licensing Act on violence. There is no evidence for the Act having a significant or consistent effect on community violence

  1. A QSAR study on the inhibition mechanism of matrix metalloproteinase-12 by arylsulfone analogs based on molecular orbital calculations.

    Science.gov (United States)

    Hitaoka, Seiji; Chuman, Hiroshi; Yoshizawa, Kazunari

    2015-01-21

    A binding mechanism between human matrix metalloproteinase-12 (MMP-12) and eight arylsulfone analogs having two types of carboxylic and hydroxamic acids as the most representative zinc binding group is investigated using a quantitative structure-activity relationship (QSAR) analysis based on a linear expression by representative energy terms (LERE). The LERE-QSAR analysis quantitatively reveals that the variation in the observed (experimental) inhibitory potency among the arylsulfone analogs is decisively governed by those in the intrinsic binding and dispersion interaction energies. The results show that the LERE-QSAR analysis not only can excellently reproduce the observed overall free-energy change but also can determine the contributions of representative free-energy changes. An inter-fragment interaction energy difference (IFIED) analysis based on the fragment molecular orbital (FMO) method (FMO-IFIED) leads to the identification of key residues governing the variation in the inhibitory potency as well as to the understanding of the difference between the interactions of the carboxylic and hydroxamic acid zinc binding groups. The current results that have led to the optimization of the inhibitory potency of arylsulfone analogs toward MMP-12 to be used in the treatment of chronic obstructive pulmonary disease may be useful for the development of a new potent MMP-12 inhibitor.

  2. Analog pulse processor

    Science.gov (United States)

    Wessendorf, Kurt O.; Kemper, Dale A.

    2003-06-03

    A very low power analog pulse processing system implemented as an ASIC useful for processing signals from radiation detectors, among other things. The system incorporates the functions of a charge sensitive amplifier, a shaping amplifier, a peak sample and hold circuit, and, optionally, an analog to digital converter and associated drivers.

  3. Hydraulic Capacitor Analogy

    Science.gov (United States)

    Baser, Mustafa

    2007-01-01

    Students have difficulties in physics because of the abstract nature of concepts and principles. One of the effective methods for overcoming students' difficulties is the use of analogies to visualize abstract concepts to promote conceptual understanding. According to Iding, analogies are consistent with the tenets of constructivist learning…

  4. Challenges in Using Analogies

    Science.gov (United States)

    Lin, Shih-Yin; Singh, Chandralekha

    2011-01-01

    Learning physics requires understanding the applicability of fundamental principles in a variety of contexts that share deep features. One way to help students learn physics is via analogical reasoning. Students can be taught to make an analogy between situations that are more familiar or easier to understand and another situation where the same…

  5. Licensing-In Fosters Rapid Invention!

    DEFF Research Database (Denmark)

    Leone, Maria Isabella; Reichstein, Toke

    2012-01-01

    Drawing on contractual economics and innovation management, licensing-in is hypothesized to accelerate licensees' invention process. Studying a matched dataset of licensees and non-licensees, licensees are shown to be faster at inventing, but the effect is negated if the license includes a grant......-back clause, shifting incentives from licensee to licensor. Also, the effect is significantly reduced if the licensee is unfamiliar with the licensed technology. The effect of the grant-back clause is offset if the licensee is unfamiliar with the licensed technology, suggesting that the licensee retains...

  6. NRC's license renewal regulations

    International Nuclear Information System (INIS)

    Akstulewicz, Francis

    1991-01-01

    In order to provide for the continuity of the current generation of nuclear power plant operating licenses and at the same time ensure the health and safety of the public, and the quality of the environment, the US Nuclear Regulatory Commission (NRC) established a goal of developing and issuing regulations and regulatory guidance for license renewal in the early 1990s. This paper will discuss some of those activities underway to achieve this goal. More specifically, this paper will discuss the Commission's regulatory philosophy for license renewal and the two major license renewal rule makings currently underway. The first is the development of a new Part 54 to address procedural and technical requirements for license renewal; the second is a revision to existing Part 51 to exclude environmental issues and impacts from consideration during the license renewal process. (author)

  7. Terrestrial Analog Field Investigations to Enable Science and Exploration Studies of Impacts and Volcanism on the Moon, NEAs, and Moons of Mars

    Science.gov (United States)

    Heldmann, Jennifer Lynne; Colaprete, Anthony; Cohen, Barbara; Elphic, Richard; Garry, William; Hodges, Kip; Hughes, Scott; Kim, Kyeon; Lim, Darlene; McKay, Chris; hide

    2013-01-01

    Terrestrial analog studies are a critical component for furthering our understanding of geologic processes on the Moon, near-Earth asteroids (NEAs), and the moons of Mars. Carefully chosen analog sites provide a unique natural laboratory with high relevance to the associated science on these solar system target bodies. Volcanism and impact cratering are fundamental processes on the Moon, NEAs, and Phobos and Deimos. The terrestrial volcanic and impact records remain invaluable for our understanding of these processes throughout our solar system, since these are our primary source of firsthand knowledge on volcanic landform formation and modification as well as the three-dimensional structural and lithological character of impact craters. Regarding impact cratering, terrestrial fieldwork can help us to understand the origin and emplacement of impactites, the history of impact bombardment in the inner Solar System, the formation of complex impact craters, and the effects of shock on planetary materials. Volcanism is another dominant geologic process that has significantly shaped the surface of planetary bodies and many asteroids. Through terrestrial field investigations we can study the processes, geomorphic features and rock types related to fissure eruptions, volcanic constructs, lava tubes, flows and pyroclastic deposits. Also, terrestrial analog studies have the advantage of enabling simultaneous robotic and/or human exploration testing in a low cost, low risk, high fidelity environment to test technologies and concepts of operations for future missions to the target bodies. Of particular interest is the importance and role of robotic precursor missions prior to human operations for which there is little to no actual mission experience to draw upon. Also critical to understanding new worlds is sample return, and analog studies enable us to develop the appropriate procedures for collecting samples in a manner that will best achieve the science objectives.

  8. Trends in nuclear licensing

    International Nuclear Information System (INIS)

    Dalton, N.W.

    1990-01-01

    The development of nuclear safety and licensing is briefly reviewed in four stages namely: The Formative Period (1946-1959), The Expansive Period (1960-1969), The Mature Period (1970-1979) and the Apprehensive Period (1980-1989). Particular safety issues in the respective periods are highlighted to indicate the changing emphasis of nuclear licensing over the past thirty years or so. Against this background, nuclear licensing. (author)

  9. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1993-01-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

  10. Libraries and licensing

    Directory of Open Access Journals (Sweden)

    Maja Žumer

    2001-01-01

    Full Text Available In the mid 90s, the abundance of various electronic publications exposed libraries to the problems of licensing electronic content. Various licensing principles have been prepared recently to help libraries in the process; it can be said that in general, the knowledge of licensing issues has improved in libraries of all types. Libraries form consortia in order to gain stronger negotiating positions and obtain better conditions.In the article, new licensing principles are presented in more detail, as well as some domestic and foreign experiences with consortia forming.

  11. Properties of compressible elastica from relativistic analogy.

    Science.gov (United States)

    Oshri, Oz; Diamant, Haim

    2016-01-21

    Kirchhoff's kinetic analogy relates the deformation of an incompressible elastic rod to the classical dynamics of rigid body rotation. We extend the analogy to compressible filaments and find that the extension is similar to the introduction of relativistic effects into the dynamical system. The extended analogy reveals a surprising symmetry in the deformations of compressible elastica. In addition, we use known results for the buckling of compressible elastica to derive the explicit solution for the motion of a relativistic nonlinear pendulum. We discuss cases where the extended Kirchhoff analogy may be useful for the study of other soft matter systems.

  12. Data-mining to build a knowledge representation store for clinical decision support. Studies on curation and validation based on machine performance in multiple choice medical licensing examinations.

    Science.gov (United States)

    Robson, Barry; Boray, Srinidhi

    2016-06-01

    Extracting medical knowledge by structured data mining of many medical records and from unstructured data mining of natural language source text on the Internet will become increasingly important for clinical decision support. Output from these sources can be transformed into large numbers of elements of knowledge in a Knowledge Representation Store (KRS), here using the notation and to some extent the algebraic principles of the Q-UEL Web-based universal exchange and inference language described previously, rooted in Dirac notation from quantum mechanics and linguistic theory. In a KRS, semantic structures or statements about the world of interest to medicine are analogous to natural language sentences seen as formed from noun phrases separated by verbs, prepositions and other descriptions of relationships. A convenient method of testing and better curating these elements of knowledge is by having the computer use them to take the test of a multiple choice medical licensing examination. It is a venture which perhaps tells us almost as much about the reasoning of students and examiners as it does about the requirements for Artificial Intelligence as employed in clinical decision making. It emphasizes the role of context and of contextual probabilities as opposed to the more familiar intrinsic probabilities, and of a preliminary form of logic that we call presyllogistic reasoning. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Habitability: where lo look for life? Halophilic habitats: earth analogs to study Mars and Europá s habitability

    Science.gov (United States)

    Gómez, F.; Gómez-Elvira, J.; Rodríguez, N.; Caballero Castrejón, J. F.; Amils, R.; Rodríguez-Manfredi, J. A.

    2009-04-01

    Current Mars exploration is producing a considerable amount of information which requires comparison with terrestrial analogs in order to interpret and evaluate compatibility with possible extinct and/or extant life on the planet. The first astrobiological mission specially designed to detect life on Mars, the Viking missions, thought life unlikely, considering the amount of UV radiation bathing the surface of the planet, the resulting oxidative conditions, and the lack of adequate atmospheric protection. The necessity of the Europa surface exploration comes from the idea of a water ocean existence in its interior. Europa surface presents evidence of an active geology showing many tectonic features that seems to be connected with some liquid interior reservoir. Life needs several requirements for its establishment but, the only sine qua nom elements is the water, taking into account our experience on Earth extreme ecosystems The discovery of extremophiles on Earth widened the window of possibilities for life to develop in the universe, and as a consequence on Mars. The compilation of data produced by the ongoing missions (Mars Global Surveyor, Mars Odyssey, Mars Express and Mars Exploration Rover Opportunity) offers a completely different view: signs of an early wet Mars and rather recent volcanic activity. The discovery of important accumulations of sulfates, and the existence of iron minerals like jarosite, goethite and hematite in rocks of sedimentary origin has allowed specific terrestrial models related with this type of mineralogy to come into focus. Río Tinto (Southwestern Spain, Iberian Pyritic Belt) is an extreme acidic environment, product of the chemolithotrophic activity of microorganisms that thrive in the massive pyrite-rich deposits of the Iberian Pyritic Belt. The high concentrations of ferric iron and sulfates, products of the metabolism of pyrite, generate a collection of minerals, mainly gypsum, jarosite, goethite and hematites, all of which

  14. Patterns of Analogical Reasoning among Beginning Readers

    Science.gov (United States)

    Farrington-Flint, Lee; Wood, Clare; Canobi, Katherine H.; Faulkner, Dorothy

    2004-01-01

    Despite compelling evidence that analogy skills are available to beginning readers, few studies have actually explored the possibility of identifying individual differences in young children's analogy skills in early reading. The present study examined individual differences in children's use of orthographic and phonological relations between…

  15. Troubleshooting analog circuits

    CERN Document Server

    Pease, Robert A

    1991-01-01

    Troubleshooting Analog Circuits is a guidebook for solving product or process related problems in analog circuits. The book also provides advice in selecting equipment, preventing problems, and general tips. The coverage of the book includes the philosophy of troubleshooting; the modes of failure of various components; and preventive measures. The text also deals with the active components of analog circuits, including diodes and rectifiers, optically coupled devices, solar cells, and batteries. The book will be of great use to both students and practitioners of electronics engineering. Other

  16. Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor

    Directory of Open Access Journals (Sweden)

    Chean Hui Ng

    2014-08-01

    Full Text Available The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides. The search for selective LOX inhibitors may provide new therapeutic approach for inflammatory diseases. Herein, we report the synthesis of tHGA analogs using simple Friedel-Craft acylation and alkylation reactions with the aim of obtaining a better insight into the structure-activity relationships of the compounds. All the synthesized analogs showed potent soybean 15-LOX inhibitory activity in a dose-dependent manner (IC50 = 10.31–27.61 μM where compound 3e was two-fold more active than tHGA. Molecular docking was then applied to reveal the important binding interactions of compound 3e in soybean 15-LOX binding site. The findings suggest that the presence of longer acyl bearing aliphatic chain (5Cs and aromatic groups could significantly affect the enzymatic activity.

  17. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.

    Science.gov (United States)

    Kumar, Vidya P; Cisneros, Jose A; Frey, Kathleen M; Castellanos-Gonzalez, Alejandro; Wang, Yiqiang; Gangjee, Aleem; White, A Clinton; Jorgensen, William L; Anderson, Karen S

    2014-09-01

    Cryptosporidium is the causative agent of a gastrointestinal disease, cryptosporidiosis, which is often fatal in immunocompromised individuals and children. Thymidylate synthase (TS) and dihydrofolate reductase (DHFR) are essential enzymes in the folate biosynthesis pathway and are well established as drug targets in cancer, bacterial infections, and malaria. Cryptosporidium hominis has a bifunctional thymidylate synthase and dihydrofolate reductase enzyme, compared to separate enzymes in the host. We evaluated lead compound 1 from a novel series of antifolates, 2-amino-4-oxo-5-substituted pyrrolo[2,3-d]pyrimidines as an inhibitor of Cryptosporidium hominis thymidylate synthase with selectivity over the human enzyme. Complementing the enzyme inhibition compound 1 also has anti-cryptosporidial activity in cell culture. A crystal structure with compound 1 bound to the TS active site is discussed in terms of several van der Waals, hydrophobic and hydrogen bond interactions with the protein residues and the substrate analog 5-fluorodeoxyuridine monophosphate (TS), cofactor NADPH and inhibitor methotrexate (DHFR). Another crystal structure in complex with compound 1 bound in both the TS and DHFR active sites is also reported here. The crystal structures provide clues for analog design and for the design of ChTS-DHFR specific inhibitors. Copyright © 2014. Published by Elsevier Ltd.

  18. License renewal process

    International Nuclear Information System (INIS)

    Fable, D.; Prah, M.; Vrankic, K.; Lebegner, J.

    2004-01-01

    The purpose of this paper is to provide information about license renewal process, as defined by Nuclear Regulatory Commission (NRC). The Atomic Energy Act and NRC regulations limit commercial power reactor licenses to an initial 40 years but also permit such licenses to be renewed. This original 40-year term for reactor licenses was based on economic and antitrust considerations not on limitations of nuclear technology. Due to this selected time period; however, some structures and components may have been engineered on the basis of an expected 40-year service life. The NRC has established a timely license renewal process and clear requirements codified in 10 CFR Part 51 and 10 CFR Part 54, that are needed to assure safe plant operation for extended plant life. The timely renewal of licenses for an additional 20 years, where appropriate to renew them, may be important to ensuring an adequate energy supply during the first half of the 21st Century. License renewal rests on the determination that currently operating plants continue to maintain adequate levels of safety, and over the plant's life, this level has been enhanced through maintenance of the licensing bases, with appropriate adjustments to address new information from industry operating experience. Additionally, NRC activities have provided ongoing assurance that the licensing bases will continue to provide an acceptable level of safety. This paper provides additional discussion of license renewal costs, as one of key elements in evaluation of license renewal justifiability. Including structure of costs, approximately value and two different approaches, conservative and typical. Current status and position of Nuclear Power Plant Krsko, related to license renewal process, will be briefly presented in this paper. NPP Krsko is designed based on NRC Regulations, so requirements from 10 CFR 51, and 10 CFR 54, are applicable to NPP Krsko, as well. Finally, this paper will give an overview of current status of

  19. The SLOWPOKE licensing model

    International Nuclear Information System (INIS)

    Snell, V.G.

    1992-01-01

    The SLOWPOKE Energy System (SES-10) is a 10 MW heating reactor that has been developed in Canada. It will be capable of running without a licensed operator in continuous attendance, and will be sited in urban areas. It has forgiving safety characteristics, including transient time-scales of the order of hours. A process called 'up-front' licensing has been evolved in Canada to identify, and resolve, regulatory concerns early in the process. Because of the potential market in Hungary for nuclear district heating, a licensing plan has been developed that incorporates Canadian licensing experience, identifies specific Hungarian requirements, and reduces the risk of licensing delays by seeking agreement of all parties at an early stage in the program. (orig.)

  20. The SLOWPOKE licensing model

    International Nuclear Information System (INIS)

    Snell, V.G.; Takats, F.; Szivos, K.

    1989-08-01

    The SLOWPOKE Energy System (SES-10) is a 10 MW heating reactor that has been developed in Canada. It will be capable of running without a licensed operator in continuous attendance, and will be sited in urban areas. It has forgiving safety characteristics, including transient time-scales of the order of hours. A process called 'up-front' licensing has been evolved in Canada to identify, and resolve, regulatory concerns early in the process. Because of the potential market in Hungary for nuclear district heating, a licensing plan has been developed that incorporates Canadian licensing experience, identifies specific Hungarian requirements, and reduces the risk of licensing delays by seeking agreement of all parties at an early stage in the program

  1. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1983-10-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

  2. Natural analogs in the host rock salt. Pt. 1. General study (2011). Pt. 2. Detail studies (2012-2013); Natuerliche Analoga im Wirtsgestein Salz. T. 1. Generelle Studie (2011). T. 2. Detailstudien (2012-2013)

    Energy Technology Data Exchange (ETDEWEB)

    Brasser, Thomas; Fahrenholz, Christine; Kull, Herbert; Meleshyn, Artur; Moenig, Heike; Noseck, Ulrich; Schoenwiese, Dagmar; Wolf, Jens

    2014-12-15

    The first part of the project ISIBELII on natural analogs in the host rock salt included a summary of available studies on the topic to be used in a safety analysis for a final repository for heat generating radioactive waste. In 2012 the results of the preliminary safety analysis Gorleben was available, including results on the fracturing of anhydrite, the formation of cryogenic gaps and the influence of earthquakes. The requirements for the barrier system have been modified due to the safety requirements for the final disposal of heat-generating radioactive wastes valid since 2010. For containers the functionality gas to be demonstrated for 500 years. The following issues are covered: natural analogs for the integrity demonstration of the geological barrier, natural analogs for the integrity demonstration of geotechnical barriers, natural analogs for the evaluation of release scenarios. The detail studies include anhydrite fracturing, salt grit compaction, chemical composition of fluid inclusions, thermal stability of salt rock, mechanical stability of salt rock, influence of earthquakes, qualified closures, iron corrosion, and microbial processes.

  3. Analog multivariate counting analyzers

    CERN Document Server

    Nikitin, A V; Armstrong, T P

    2003-01-01

    Characterizing rates of occurrence of various features of a signal is of great importance in numerous types of physical measurements. Such signal features can be defined as certain discrete coincidence events, e.g. crossings of a signal with a given threshold, or occurrence of extrema of a certain amplitude. We describe measuring rates of such events by means of analog multivariate counting analyzers. Given a continuous scalar or multicomponent (vector) input signal, an analog counting analyzer outputs a continuous signal with the instantaneous magnitude equal to the rate of occurrence of certain coincidence events. The analog nature of the proposed analyzers allows us to reformulate many problems of the traditional counting measurements, and cast them in a form which is readily addressed by methods of differential calculus rather than by algebraic or logical means of digital signal processing. Analog counting analyzers can be easily implemented in discrete or integrated electronic circuits, do not suffer fro...

  4. Licensing in the Patent Thicket - Timing and Benefits

    OpenAIRE

    Siebert, Ralph; Von Graevenitz, Georg

    2011-01-01

    Licensing can be a solution for hold-up in patent thickets. In this paper we study whether licensing is an effective solution for hold-up. To do this we distinguish between ex ante and ex post licensing. A theoretical model shows that firms’ expectations of blocking in a patent thicket determine whether they license ex ante while ex post licensing arises if expected blocking was low but realized blocking turns out to be high. It can also be shown that ex ante licensing will allow firms to ...

  5. EPRI support of license renewal

    International Nuclear Information System (INIS)

    Byron, Jeff; Carey, John J.

    1991-01-01

    During the early 1980's, the US utility industry recognized that Light Water Reactors (LWRs) could have a useful life substantially in excess of the current licensed term of 40 years service. These observations were confirmed by two plant specific studies and have led to a major initiative undertaken by EPRI and DOE to demonstrate the technical and institutional basis for a predictable, rational, and stable life extension option. The primary objective of the lead plants project is to establish and demonstrate, by the end of 1993, nuclear plant license renewal as a viable option. As part of this initiative, the lead plants project will result in a complete license renewal application to the NRC and will document the license renewal process for use by other utilities. A number of EPRI and DOE sponsored projects are providing technical support for the license renewal process. These projects are identifying deteriorating service environments for key components, systems, and structures and are establishing methods of assessing consequences and remedial actions. Other projects include economic evaluations and life cycle management assessment tools to address deterioration mechanisms. However, the principal means for providing technical support for license renewal is the generic Industry Reports (IRs), which as of October 1990, have all been submitted to the NRC for review. The IRs discussed in this paper are intended to identify and resolve key technical issues associated with extended operation of major LWR components, structures, and systems. The principle means of providing technical support for license renewal is the IRs whose objective is to document results of generic component, structure, or system evaluations to support life extension by addressing potential impacts of aging on components, structures, or systems as it relates to the plant's performance for extended service. Ten IRs on major components or systems have been completed and submitted to the NRC. The

  6. Analog circuits cookbook

    CERN Document Server

    Hickman, Ian

    2013-01-01

    Analog Circuits Cookbook presents articles about advanced circuit techniques, components and concepts, useful IC for analog signal processing in the audio range, direct digital synthesis, and ingenious video op-amp. The book also includes articles about amplitude measurements on RF signals, linear optical imager, power supplies and devices, and RF circuits and techniques. Professionals and students of electrical engineering will find the book informative and useful.

  7. FGF growth factor analogs

    Energy Technology Data Exchange (ETDEWEB)

    Zamora, Paul O [Gaithersburg, MD; Pena, Louis A [Poquott, NY; Lin, Xinhua [Plainview, NY; Takahashi, Kazuyuki [Germantown, MD

    2012-07-24

    The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

  8. Licensing by modification Licensing by modification

    Directory of Open Access Journals (Sweden)

    Veneeta Dayal

    2008-04-01

    Full Text Available Abstract: This paper looks at the phenomena of licensing by modification, whereby an unacceptable noun phrase is redeemed by the presence of a modifier or an unavailable reading for a noun phrase is made available with the addition of a modifier. It argues that an optimal account of such phenomena should derive these effects from the interaction of the meanings of individual expressions in the sentence rather than by positing a formal licensing relation between the modifier and the noun it modifies. The general approach is explicated by considering the distribution of bare plurals in Italian and the availability of generic readings for plural definites in English. The overall goal is a modest one. It seeks to draw attention to properties of modification that go beyond set intersection by focusing on phenomena that have not so far been closely scrutinized in the literature. It uses the particular results to draw some conclusions about questions of general interest.Licensing by modification Abstract: This paper looks at the phenomena of licensing by modification, whereby an unacceptable noun phrase is redeemed by the presence of a modifier or an unavailable reading for a noun phrase is made available with the addition of a modifier. It argues that an optimal account of such phenomena should derive these effects from the interaction of the meanings of individual expressions in the sentence rather than by positing a formal licensing relation between the modifier and the noun it modifies. The general approach is explicated by considering the distribution of bare plurals in Italian and the availability of generic readings for plural definites in English. The overall goal is a modest one. It seeks to draw attention to properties of modification that go beyond set intersection by focusing on phenomena that have not so far been closely scrutinized in the literature. It uses the particular results to draw some conclusions about questions of general

  9. Young Children's Analogical Reasoning in Science Domains

    Science.gov (United States)

    Haglund, Jesper; Jeppsson, Fredrik; Andersson, Johanna

    2012-01-01

    This exploratory study in a classroom setting investigates first graders' (age 7-8 years, N = 25) ability to perform analogical reasoning and create their own analogies for two irreversible natural phenomena: mixing and heat transfer. We found that the children who contributed actively to a full-class discussion were consistently successful at…

  10. Children's Use of Analogy during Collaborative Reasoning

    Science.gov (United States)

    Lin, Tzu-Jung; Anderson, Richard C.; Hummel, John E.; Jadallah, May; Miller, Brian W.; Nguyen-Jahiel, Kim; Morris, Joshua A.; Kuo, Li-Jen; Kim, Il-Hee; Wu, Xiaoying; Dong, Ting

    2012-01-01

    This microgenetic study examined social influences on children's development of analogical reasoning during peer-led small-group discussions of stories about controversial issues. A total of 277 analogies were identified among 7,215 child turns for speaking during 54 discussions from 18 discussion groups in 6 fourth-grade classrooms (N = 120; age…

  11. Do recreational cannabis users, unlicensed and licensed medical cannabis users form distinct groups?

    Science.gov (United States)

    Sznitman, Sharon R

    2017-04-01

    This study aims to gain a more nuanced perspective on the differences between recreationally and medically motivated cannabis use by distinguishing between people who use cannabis for recreational purposes, unlicensed and licensed medical users. Data collection was conducted online from a convenience sample of 1479 Israeli cannabis users. Multinomial regression analysis compared unlicensed medical users (38%) with recreational (42%) and licensed medical (5.6%) users in terms of sociodemographics, mode, frequency and problematic cannabis use. There were more variables distinguishing unlicensed from licensed users than there were distinguishing features between unlicensed and recreational users. Recreational users were more likely to be male, less likely to eat cannabis, to use cannabis frequently and to use alone and before midday than unlicensed users. Licensed users were older than unlicensed users, they reported less hours feeling stoned, less cannabis use problems and they were more likely to report cannabis use patterns analogous of medication administration for chronic problems (frequent use, vaping, use alone and use before midday). This study suggests that a sizable proportion of cannabis users in Israel self-prescribe cannabis and that licensed medical cannabis users differ from unlicensed users. This is, in turn, suggestive of a rigorous medicalized cannabis program that does not function as a backdoor for legal access to recreational use. However, due to methodological limitations this conclusion is only suggestive. The most meaningful differences across recreational, unlicensed and licensed users were mode and patterns of use rather than cannabis use problems. Current screening tools for cannabis use problems may, however, not be well suited to assess such problems in medically motivated users. Indeed, when screening for problematic cannabis use there is a need for a more careful consideration of whether or not cannabis use is medically motivated

  12. Expert analogy use in a naturalistic setting

    Science.gov (United States)

    Kretz, Donald R.; Krawczyk, Daniel C.

    2014-01-01

    The use of analogy is an important component of human cognition. The type of analogy we produce and communicate depends heavily on a number of factors, such as the setting, the level of domain expertise present, and the speaker's goal or intent. In this observational study, we recorded economics experts during scientific discussion and examined the categorical distance and structural depth of the analogies they produced. We also sought to characterize the purpose of the analogies that were generated. Our results supported previous conclusions about the infrequency of superficial similarity in subject-generated analogs, but also showed that distance and depth characteristics were more evenly balanced than in previous observational studies. This finding was likely due to the nature of the goals of the participants, as well as the broader nature of their expertise. An analysis of analogical purpose indicated that the generation of concrete source examples of more general target concepts was most prevalent. We also noted frequent instances of analogies intended to form visual images of source concepts. Other common purposes for analogies were the addition of colorful speech, inclusion (i.e., subsumption) of a target into a source concept, or differentiation between source and target concepts. We found no association between depth and either of the other two characteristics, but our findings suggest a relationship between purpose and distance; i.e., that visual imagery typically entailed an outside-domain source whereas exemplification was most frequently accomplished using within-domain analogies. Overall, we observed a rich and diverse set of spontaneously produced analogical comparisons. The high degree of expertise within the observed group along with the richly comparative nature of the economics discipline likely contributed to this analogical abundance. PMID:25505437

  13. Expert Analogy Use in a Naturalistic Setting

    Directory of Open Access Journals (Sweden)

    Donald R Kretz

    2014-11-01

    Full Text Available The use of analogy is an important component of human cognition. The type of analogy we produce and communicate depends heavily on a number of factors, such as the setting, the level of domain expertise present, and the speaker’s goal or intent. In this observational study, we recorded economics experts during scientific discussion and examined the categorical distance and structural depth of the analogies they produced. We also sought to characterize the purpose of the analogies that were generated. Our results supported previous conclusions about the infrequency of superficial similarity in subject-generated analogs, but also showed that distance and depth characteristics were more evenly balanced than in previous observational studies. This finding was likely due to the nature of the goals of the participants, as well as the broader nature of their expertise. An analysis of analogical purpose indicated that the generation of concrete source examples of more general target concepts was most prevalent. We also noted frequent instances of analogies intended to form visual images of source concepts. Other common purposes for analogies were the addition of colorful speech, inclusion (i.e., subsumption of a target into a source concept, or differentiation between source and target concepts. We found no association between depth and either of the other two characteristics, but our findings suggest a relationship between purpose and distance; i.e., that visual imagery typically entailed an outside-domain source whereas exemplification was most frequently accomplished using within-domain analogies. Overall, we observed a rich and diverse set of spontaneously produced analogical comparisons. The high degree of expertise within the observed group along with the richly comparative nature of the economics discipline likely contributed to this analogical abundance.

  14. Electrical Circuits and Water Analogies

    Science.gov (United States)

    Smith, Frederick A.; Wilson, Jerry D.

    1974-01-01

    Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

  15. Growth hormone receptor variants and response to pegvisomant in monotherapy or in combination with somatostatin analogs in acromegalic patients: a multicenter study.

    Science.gov (United States)

    Filopanti, M; Olgiati, L; Mantovani, G; Corbetta, S; Arosio, M; Gasco, V; De Marinis, L; Martini, C; Bogazzi, F; Cannavò, S; Colao, A; Ferone, D; Arnaldi, G; Pigliaru, F; Peri, A; Angeletti, G; Jaffrain-Rea, M L; Lania, A G; Spada, A

    2012-02-01

    The influence of full-length GH receptor (GHR) and exon 3-deleted GHR (d3GHR) on responsiveness to pegvisomant (PEG-V) in acromegalic patients is uncertain. The aim of the study was to assess the distribution of GHR genotypes in a large series of patients on PEG-V therapy and their influence on treatment efficacy and adverse effects. A cross-sectional multicenter pharmacogenetic study was conducted in 16 Italian endocrinology centers of major universities and tertiary care hospitals. The study included 127 acromegalic patients enrolled from 2009 to 2010 not cured by previous surgery, radiotherapy, and long-acting somatostatin (SST) analogs, treated with PEG-V. Sixty-three of 127 patients received combined PEG-V + SST analog therapy. Clinical and hormonal data at diagnosis and before and during PEG-V therapy were inserted in a database. GHR exon 3 deletion and other polymorphisms were genotyped by the coordinator center. Differences in PEG-V dosage required for IGF-I normalization and occurrence of adverse effects between carriers and noncarriers of GHR variants were evaluated. d3GHR variants were not in Hardy-Weinberg equilibrium (P = 0.008). No association of these variants with PEG-V dose required for IGF-I normalization, adverse effects occurrence, and tumor regrowth was found in patients on PEG-V and on PEG-V + SST analog treatment. Similar data were obtained considering the GHR variant rs6180. This study did not confirm a better response of d3GHR to PEG-V treatment in acromegaly. Other studies are needed to determine whether deviation from Hardy-Weinberg equilibrium may indicate an association of d3GHR genotype with poor response to usual treatments.

  16. Licensing aspects regarding the RBMN project

    International Nuclear Information System (INIS)

    Cuccia, Valeria; Sacramento, Arivaldo M.; Aleixo, Bruna L.; Ferreira, Vinicius V.M.

    2013-01-01

    The licensing process of a waste disposal facility is a complex and demanding undertaking. It proceeds in phases, starting with the site selection and ending many decades later, when the radionuclides decayed and no longer offer possible hazard. That is one of the reasons why the licensing process for the Brazilian repository for low and intermediate level radioactive waste (RBMN Project) is a challenge for all the technicians involved. Besides that, the only national experience associated to this subject arose after a radiological accident in the State of Goias, in 1987. Two different institutions are involved in this licensing process: IBAMA, for environmental licensing, and CNEN, for nuclear licensing. Both of them will evaluate the possible impacts caused by the waste disposal, so it is essential to avoid conflicts and duplications of activities. The RBMN project has different teams for each main activity, and one of them is the Licensing group. This team has been planning the licensing activities for the repository, studying the legal framework and estimating costs and execution time for each step. This paper presents the status of the licensing activities regarding to the RBMN project done by the CNEN staff. (author)

  17. Licensing aspects regarding the RBMN project

    Energy Technology Data Exchange (ETDEWEB)

    Cuccia, Valeria; Sacramento, Arivaldo M.; Aleixo, Bruna L.; Ferreira, Vinicius V.M., E-mail: vc@cdtn.br, E-mail: ams@cdtn.br, E-mail: bla@cdtn.br, E-mail: vvmf@cdtn.br [Centro de Desenvolvimento de Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    The licensing process of a waste disposal facility is a complex and demanding undertaking. It proceeds in phases, starting with the site selection and ending many decades later, when the radionuclides decayed and no longer offer possible hazard. That is one of the reasons why the licensing process for the Brazilian repository for low and intermediate level radioactive waste (RBMN Project) is a challenge for all the technicians involved. Besides that, the only national experience associated to this subject arose after a radiological accident in the State of Goias, in 1987. Two different institutions are involved in this licensing process: IBAMA, for environmental licensing, and CNEN, for nuclear licensing. Both of them will evaluate the possible impacts caused by the waste disposal, so it is essential to avoid conflicts and duplications of activities. The RBMN project has different teams for each main activity, and one of them is the Licensing group. This team has been planning the licensing activities for the repository, studying the legal framework and estimating costs and execution time for each step. This paper presents the status of the licensing activities regarding to the RBMN project done by the CNEN staff. (author)

  18. Neutrophils Induced Licensing of Natural Killer Cells

    Directory of Open Access Journals (Sweden)

    Keishiro Amano

    2015-01-01

    Full Text Available Natural killer (NK cells acquire effector function through a licensing process and exert anti-leukemia/tumor effect. However, there is no means to promote a licensing effect of allogeneic NK cells other than cytomegalovirus reactivation-induced licensing in allogeneic hematopoietic stem cell transplantation in human. In mice, a licensing process is mediated by Ly49 receptors which recognize self-major histocompatibility complex class I. The distribution of four Ly49 receptors showed similar pattern in congenic mice, B10, B10.BR, and B10.D2, which have B10 background. Forty Gy-irradiated 2×106 B10.D2 cells including splenocytes, peripheral blood mononuclear cells in untreated mice, or granulocyte colony-stimulating factor treated mice were injected intraperitoneally into B10 mice. We found that murine NK cells were effectively licensed by intraperitoneal injection of donor neutrophils with its corresponding NK receptor ligand in B10 mice as a recipient and B10.D2 as a donor. Mechanistic studies revealed that NK cells showed the upregulation of intracellular interferon-γ and CD107a expression as markers of NK cell activation. Moreover, enriched neutrophils enhanced licensing effect of NK cells; meanwhile, licensing effect was diminished by depletion of neutrophils. Collectively, injection of neutrophils induced NK cell licensing (activation via NK receptor ligand interaction.

  19. Product Licenses Database Application

    CERN Document Server

    Tonkovikj, Petar

    2016-01-01

    The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

  20. Archaeological analogous and industrials for deep storage: study of the archaeological metallic piece; Analogos arqueologicos e industriales para almacenamientos profundos: estudio de piezas arqueologicas metalicas

    Energy Technology Data Exchange (ETDEWEB)

    Criado Portal, A. J.; Martinez Garcia, J. A.; Calabres Molina, R.; Garcia abajo, A.; Penco Valenzuela, F.; Lecanda Esteban, J. A.; Garcia Bartual, M.; Jimenez Gonzalez, J. M.; Bravo Munoz, E.; Rodriguez Lobo, L. M.; Fernandez Cascos, T.; Fernandes Cordero, O.; Montero Ruiz, I.

    2000-07-01

    The aim of present research is to obtain information about archaeological analogous of iron and steel, useful for the model of deep geological repository (AGP). The analogous examined have remained buried between 1400 and 2400 years, in very assorted geochemical environments. The extraction of the archaeological pieces has been accomplished according to normalised protocols, trying to carry to the laboratory so the piece as its burial environment, avoiding all possible pollution. Trying to the archaeological analogous could provide valuable information to the AGP model, the study has been directed to related the physical-chemical characteristics of the terrain respect to the deterioration of the archaeological metallic piece. The geology of the surrounding terrain to the archaeological deposit, the geomorphological study of the terrain and data from the analysis of ground: pH, wetness, porosity, organic matter contents, bacteria presence, sulphates, carbonates, chlorides, etc., have allowed to explain the physical-chemical phenomena suffered by the archaeological iron and steel pieces. Also, an exhaustive study of the archaeological piece has been accomplished, concerning the microstructure of the corrosion layer and of the not deteriorated metallic rest. Obtained information concerns different items, such as corrosion velocity and formations of oxide layers, diffusion of chemical elements from the corrosion layer to the metal and viceversa, and structural changes in oxide layers and in the metallic remains by structural ageing. Obtained data have allowed to develop a mathematical model for calculation of corrosion velocity in buried iron and steels, based on physical-chemical variables of grounds, chemical composition and thermomechanical treatment given to the metal during its manufacture. (Author)

  1. Antibacterial and Antibiofilm Activities of Makaluvamine Analogs

    Directory of Open Access Journals (Sweden)

    Bhavitavya Nijampatnam

    2014-09-01

    Full Text Available Streptococcus mutans is a key etiological agent in the formation of dental caries. The major virulence factor is its ability to form biofilms. Inhibition of S. mutans biofilms offers therapeutic prospects for the treatment and the prevention of dental caries. In this study, 14 analogs of makaluvamine, a marine alkaloid, were evaluated for their antibacterial activity against S. mutans and for their ability to inhibit S. mutans biofilm formation. All analogs contained the tricyclic pyrroloiminoquinone core of makaluvamines. The structural variations of the analogs are on the amino substituents at the 7-position of the ring and the inclusion of a tosyl group on the pyrrole ring N of the makaluvamine core. The makaluvamine analogs displayed biofilm inhibition with IC50 values ranging from 0.4 μM to 88 μM. Further, the observed bactericidal activity of the majority of the analogs was found to be consistent with the anti-biofilm activity, leading to the conclusion that the anti-biofilm activity of these analogs stems from their ability to kill S. mutans. However, three of the most potent N-tosyl analogs showed biofilm IC50 values at least an order of magnitude lower than that of bactericidal activity, indicating that the biofilm activity of these analogs is more selective and perhaps independent of bactericidal activity.

  2. Structure problems in the analog computation

    International Nuclear Information System (INIS)

    Braffort, P.L.

    1957-01-01

    The recent mathematical development showed the importance of elementary structures (algebraic, topological, etc.) in abeyance under the great domains of classical analysis. Such structures in analog computation are put in evidence and possible development of applied mathematics are discussed. It also studied the topological structures of the standard representation of analog schemes such as additional triangles, integrators, phase inverters and functions generators. The analog method gives only the function of the variable: time, as results of its computations. But the course of computation, for systems including reactive circuits, introduces order structures which are called 'chronological'. Finally, it showed that the approximation methods of ordinary numerical and digital computation present the same structure as these analog computation. The structure analysis permits fruitful comparisons between the several domains of applied mathematics and suggests new important domains of application for analog method. (M.P.)

  3. Computational approaches to analogical reasoning current trends

    CERN Document Server

    Richard, Gilles

    2014-01-01

    Analogical reasoning is known as a powerful mode for drawing plausible conclusions and solving problems. It has been the topic of a huge number of works by philosophers, anthropologists, linguists, psychologists, and computer scientists. As such, it has been early studied in artificial intelligence, with a particular renewal of interest in the last decade. The present volume provides a structured view of current research trends on computational approaches to analogical reasoning. It starts with an overview of the field, with an extensive bibliography. The 14 collected contributions cover a large scope of issues. First, the use of analogical proportions and analogies is explained and discussed in various natural language processing problems, as well as in automated deduction. Then, different formal frameworks for handling analogies are presented, dealing with case-based reasoning, heuristic-driven theory projection, commonsense reasoning about incomplete rule bases, logical proportions induced by similarity an...

  4. Allegheny County Dog Licenses

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — A list of dog license dates, dog breeds, and dog name by zip code. Currently this dataset does not include City of Pittsburgh dogs.

  5. License to build

    International Nuclear Information System (INIS)

    Huntelaar, Mark; Vos, Renate de; Roobol, Lars

    2007-01-01

    Full text: A new license under the nuclear power act is applied for at the Dutch Government for the building of a High Active Repackaging Unit (HAVA-VU in Dutch) at NRG in Petten, The Netherlands. This new building is necessary to comply with our nuclear license to dispose of high active nuclear waste at Petten to the intermediate storage facility (COVRA). In the first part of this paper attention is given to the formal procedure followed by the Government, what type of documents are to be submitted, what time frames are followed, how citizen participation is organized, and as final result a new license. In the second part more detailed information is given about the present license renewal needed for the High Active Repackaging Unit

  6. Credentialing, Licensing, and Education

    Science.gov (United States)

    ... V W X Y Z Credentialing, Licensing, and Education Share: On This Page Introduction Key Points Keep ... their patients, while other states specifically prohibit it. Education and Training Professional organizations offer certification examinations to ...

  7. CMOS analog circuit design

    CERN Document Server

    Allen, Phillip E

    1987-01-01

    This text presents the principles and techniques for designing analog circuits to be implemented in a CMOS technology. The level is appropriate for seniors and graduate students familiar with basic electronics, including biasing, modeling, circuit analysis, and some familiarity with frequency response. Students learn the methodology of analog integrated circuit design through a hierarchically-oriented approach to the subject that provides thorough background and practical guidance for designing CMOS analog circuits, including modeling, simulation, and testing. The authors' vast industrial experience and knowledge is reflected in the circuits, techniques, and principles presented. They even identify the many common pitfalls that lie in the path of the beginning designer--expert advice from veteran designers. The text mixes the academic and practical viewpoints in a treatment that is neither superficial nor overly detailed, providing the perfect balance.

  8. Analogical Reasoning in Geometry Education

    Science.gov (United States)

    Magdas, Ioana

    2015-01-01

    The analogical reasoning isn't used only in mathematics but also in everyday life. In this article we approach the analogical reasoning in Geometry Education. The novelty of this article is a classification of geometrical analogies by reasoning type and their exemplification. Our classification includes: analogies for understanding and setting a…

  9. Nuclear facilities licensing

    International Nuclear Information System (INIS)

    Carvalho, A.J.M. de.

    1978-01-01

    The need for the adoption of a legal and normative system, defining objectives, pescriptions and the process of nuclear licensing and building of nuclear power plants in Brazil is enphasized. General rules for the development of this system are presented. The Brazilian rules on the matter are discussed. A general view of the German legal system for nuclear power plant licensing and the IAEA recommendations on the subject are finally presented. (A.L.S.L.) [pt

  10. Patent Licensing Networks

    OpenAIRE

    Doh-Shin Jeon; Yassine Lefouili

    2014-01-01

    This paper investigates the patent licensing networks formed by competing firms. Assuming that licensing agreements can involve the payment of fixed fees only and that firms compete à la Cournot, we show that the complete network is always bilaterally efficient and that the monopoly network is bilaterally efficient if the patents are complementary enough. In the case of independent patents, we fully characterize the bilaterally efficient networks and find that when the cost reduction resultin...

  11. Problems of Trademark Licensing

    OpenAIRE

    Želvys, Arūnas

    2011-01-01

    Analysis of dissertation is focused on problematic aspects of trademark license agreement that exist throughout the conclusion, validity and termination of a contract. Problematic aspects are understood as legal interpretation cases where common and special norms have to be interpreted taking into account specifics of a contract object (right to a trademark). Problematic aspects are conditioned by two reasons: non comprehensive regulation of trademark license and sui generis nature of a contr...

  12. Nonequilibrium molecular dynamics study of ring polymer melts under shear and elongation flows: A comparison with their linear analogs

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Jeongha; Kim, Jinseong; Baig, Chunggi, E-mail: cbaig@unist.ac.kr [Department of Chemical Engineering, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798 (Korea, Republic of)

    2016-07-15

    We present detailed results for the structural and rheological properties of unknotted and unconcatenated ring polyethylene (PE) melts under shear and elongation flows via direct atomistic nonequilibrium molecular dynamics simulations. Short (C{sub 78}H{sub 156}) and long (C{sub 400}H{sub 800}) ring PE melts were subjected to planar Couette flow (PCF) and planar elongational flow (PEF) across a wide range of strain rates from linear to highly nonlinear flow regimes. The results are analyzed in detail through a direct comparison with those of the corresponding linear polymers. We found that, in comparison to their linear analogs, ring melts possess rather compact chain structures at or near the equilibrium state and exhibit a considerably lesser degree of structural deformation with respect to the applied flow strength under both PCF and PEF. The large structural resistance of ring polymers against an external flow field is attributed to the intrinsic closed-loop configuration of the ring and the topological constraint of nonconcatenation between ring chains in the melt. As a result, there appears to be a substantial discrepancy between ring and linear systems in terms of their structural and rheological properties such as chain orientation, the distribution of chain dimensions, viscosity, flow birefringence, hydrostatic pressure, the pair correlation function, and potential interaction energies. The findings and conclusions drawn in this work would be a useful guide in future exploration of the characteristic dynamical and relaxation mechanisms of ring polymers in bulk or confined systems under flowing conditions.

  13. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1994-06-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes. Revision 7 was published in January 1993 and became effective in August 1993. Supplement 1 is being issued primarily to implement administrative changes to the requalification examination program resulting from the amendment to 10 CFR 55 that eliminated the requirement for every licensed operator to pass an NRC-conducted requalification examination as a condition for license renewal. The supplement does not substantially alter either the initial or requalification examination processes and will become effective 30 days after its publication is noticed in the Federal Register. The corporate notification letters issued after the effective date will provide facility licensees with at least 90 days notice that the examinations will be administered in accordance with the revised procedures

  14. Sociological impacts of nuclear generating stations - summary report on the NRC post-licensing studies. Final report 1 Oct 78-4 Jan 82

    International Nuclear Information System (INIS)

    Chalmers, J.; Pijawka, D.; Branch, K.; Bergmann, P.; Flynn, J.

    1982-07-01

    The Post-Licensing Studies had four objectives. The first was to identify the socioeconomic effects resulting from the construction and operation of each of twelve nuclear power stations. The socioeconomic variables examined included: economic, demographic, housing, government, public response, and social organization characteristics. The second objective was to determine the way in which the identified effects were evaluated by study area groups. The third objective was to identify the determinants of the project-related effects. This task required knowledge of what combination of site, project, or other determinants was responsible for the project-related effects and for the evaluation of the effects. The fourth objective was to make recommendations with respect to assessment methodologies that could best be used to project the socioeconomic effects of the construction and operation of proposed nuclear generating stations. The objectives of the Post-Licensing Studies are met by the twelve individual case studies and by the Summary Report. The case studies identified the nuclear power stations and describe the evaluation of the effects by area residents. The Summary Report describes the collective findings of the individual case studies, compares the findings across sites to identify possible determinants of the effects, and examines the implication of the findings for future siting decisions and for the methodology most appropriate for projective assessments

  15. Students' Pre- and Post-Teaching Analogical Reasoning When They Draw their Analogies

    Science.gov (United States)

    Braga Mozzer, Nilmara; Justi, Rosária

    2012-02-01

    Analogies are parts of human thought. From them, we can acquire new knowledge or change that which already exists in our cognitive structure. In this sense, understanding the analogical reasoning process becomes an essential condition to understand how we learn. Despite the importance of such an understanding, there is no general agreement in cognitive science literature about this issue. In this study, we investigated students' analogical reasoning as a creative process where an environment was set up to foster the students' generating and explaining their own analogies. Data were gathered from pre- and post-teaching interviews, in which the 13-14-year-old students were asked to make comparisons that could explain how atoms are bound. Such data supported the discussion about how students reasoned analogically. Our results made it evident that the task aims and the students' salient knowledge exerted a great influence on the drawing of analogies.

  16. A study on the effects of RGB-D database scale and quality on depth analogy performance

    Science.gov (United States)

    Kim, Sunok; Kim, Youngjung; Sohn, Kwanghoon

    2016-06-01

    In the past few years, depth estimation from a single image has received increased attentions due to its wide applicability in image and video understanding. For realizing these tasks, many approaches have been developed for estimating depth from a single image based on various depth cues such as shading, motion, etc. However, they failed to estimate plausible depth map when input color image is derived from different category in training images. To alleviate these problems, data-driven approaches have been popularly developed by leveraging the discriminative power of a large scale RGB-D database. These approaches assume that there exists appearance- depth correlation in natural scenes. However, this assumption is likely to be ambiguous when local image regions have similar appearance but different geometric placement within the scene. Recently, a depth analogy (DA) has been developed by using the correlation between color image and depth gradient. DA addresses depth ambiguity problem effectively and shows reliable performance. However, no experiments are conducted to investigate the relationship between database scale and the quality of the estimated depth map. In this paper, we extensively examine the effects of database scale and quality on the performance of DA method. In order to compare the quality of DA, we collect a large scale RGB-D database using Microsoft Kinect v1 and Kinect v2 on indoor and ZED stereo camera on outdoor environments. Since the depth map obtained by Kinect v2 has high quality compared to that of Kinect v1, the depth maps from the database from Kinect v2 are more reliable. It represents that the high quality and large scale RGB-D database guarantees the high quality of the depth estimation. The experimental results show that the high quality and large scale training database leads high quality estimated depth map in both indoor and outdoor scenes.

  17. Quantum Analog Computing

    Science.gov (United States)

    Zak, M.

    1998-01-01

    Quantum analog computing is based upon similarity between mathematical formalism of quantum mechanics and phenomena to be computed. It exploits a dynamical convergence of several competing phenomena to an attractor which can represent an externum of a function, an image, a solution to a system of ODE, or a stochastic process.

  18. Analog signal isolation techniques

    Energy Technology Data Exchange (ETDEWEB)

    Beadle, E.R.

    1992-12-31

    This paper discusses several techniques for isolating analog signals in an accelerator environment. The techniques presented here encompass isolation amplifiers, voltage-to-frequency converters (VIFCs), transformers, optocouplers, discrete fiber optics, and commercial fiber optic links. Included within the presentation of each method are the design issues that must be considered when selecting the isolation method for a specific application.

  19. Analog signal isolation techniques

    Energy Technology Data Exchange (ETDEWEB)

    Beadle, E.R.

    1992-01-01

    This paper discusses several techniques for isolating analog signals in an accelerator environment. The techniques presented here encompass isolation amplifiers, voltage-to-frequency converters (VIFCs), transformers, optocouplers, discrete fiber optics, and commercial fiber optic links. Included within the presentation of each method are the design issues that must be considered when selecting the isolation method for a specific application.

  20. Reasoning through Instructional Analogies

    Science.gov (United States)

    Kapon, Shulamit; diSessa, Andrea A.

    2012-01-01

    This article aims to account for students' assessments of the plausibility and applicability of analogical explanations, and individual differences in these assessments, by analyzing properties of students' underlying knowledge systems. We developed a model of explanation and change in explanation focusing on knowledge elements that provide a…

  1. The Paradox of Analogy

    Directory of Open Access Journals (Sweden)

    David Botting

    2012-03-01

    Full Text Available I will show that there is a type of analogical reasoning that instantiates a pattern of reasoning in confirmation theory that is considered at best paradoxical and at worst fatal to the entire syntactical approach to confirmation and explanation. However, I hope to elaborate conditions under which this is a sound (although not necessarily strong method of reasoning.

  2. Analogy, explanation, and proof

    Science.gov (United States)

    Hummel, John E.; Licato, John; Bringsjord, Selmer

    2014-01-01

    People are habitual explanation generators. At its most mundane, our propensity to explain allows us to infer that we should not drink milk that smells sour; at the other extreme, it allows us to establish facts (e.g., theorems in mathematical logic) whose truth was not even known prior to the existence of the explanation (proof). What do the cognitive operations underlying the inference that the milk is sour have in common with the proof that, say, the square root of two is irrational? Our ability to generate explanations bears striking similarities to our ability to make analogies. Both reflect a capacity to generate inferences and generalizations that go beyond the featural similarities between a novel problem and familiar problems in terms of which the novel problem may be understood. However, a notable difference between analogy-making and explanation-generation is that the former is a process in which a single source situation is used to reason about a single target, whereas the latter often requires the reasoner to integrate multiple sources of knowledge. This seemingly small difference poses a challenge to the task of marshaling our understanding of analogical reasoning to understanding explanation. We describe a model of explanation, derived from a model of analogy, adapted to permit systematic violations of this one-to-one mapping constraint. Simulation results demonstrate that the resulting model can generate explanations for novel explananda and that, like the explanations generated by human reasoners, these explanations vary in their coherence. PMID:25414655

  3. In vitro and in vivo studies in Balb-c and nude mice of a new 177Lu-Bombesin analog developed for prostate tumor diagnosis and treatment

    International Nuclear Information System (INIS)

    Pujatti, Priscilla B.; Santos, Josefina S.; Couto, Renata M.; Araujo, Elaine B. de; Mengatti, Jair; Suzuki, Miriam F.

    2009-01-01

    In this work we describe the radiolabeling with 177 Lu and some properties of the novel bombesin analog BBNp6 - DOTA-X-BBN(6-14), where X is a spacer of six aminoacids. Bombesin (BBN) is an analog of human gastrin releasing peptide (GRP) isolated from the skin of the frog Bombina bombina in 1970. Development of radiolabeled BBN derivatives as agents for diagnostic imaging and systemic radiotherapy has increased considerable because of the observation that GRP receptors (GRPr) are over-expressed in a variety of human tumor cells, such as prostate tumor cells. 177 Lu-labeled peptides are attractive due to the excellent radiophysical properties and commercial availability of the radiometal. BBNp6 was labeled with high yield after reacting with 92.5 MBq of 177 LuCl3 at 90 deg C for 30 minutes and this mixture kept stable for more than 96 hours at 4 deg C and 1 hour in human plasma. In vivo studies showed a multicompartimental distribution model with fast blood clearance, mainly performed by renal pathway. In addition, 177 Lu-BBNp6 showed high affinity for PC-3 tumor xenografts, but not for pancreas and intestine (GRP positive tissues), suggesting its specificity and usefulness for prostate tumor treatment. Moreover, scintigraphic images showed that this derivative can also be a tool in this tumor diagnosis. So, BBNp6 is a promising radiopharmaceutical for prostate tumor imaging and treatment. (author)

  4. Concept study for interim storage of research reactor fuel elements in transport and storage casks. Transport and storage licensing procedure for the CASTOR MTR 2 cask. Final report

    International Nuclear Information System (INIS)

    Weiss, M.

    2001-01-01

    As a result of the project, a concept was to be developed for managing spent fuel elements from research reactors on the basis of the interim storage technology existing in Germany, in order to make the transition to direct disposal possible in the long term. This final report describes the studies for the spent fuel management concept as well as the development of a transport and storage cask for spent fuel elements from research reactors. The concept analyses were based on data of the fuel to be disposed of, as well as the handling conditions for casks at the German research reactors. Due to the quite different conditions for handling of casks at the individual reactors, it was necessary to examine different cask concepts as well as special solutions for loading the casks outside of the spent fuel pools. As a result of these analyses, a concept was elaborated on the basis of a newly developed transport and storage cask as well as a mobile fuel transfer system for the reactor stations, at which a direct loading of the cask is not possible, as the optimal variant. The cask necessary for this concept with the designation CASTOR trademark MTR 2 follows in ist design the tried and tested principles of the CASTOR trademark casks for transport and interim storage of spent LWR fuel. With the CASTOR trademark MTR 2, it is possible to transport and to place into long term interim storage various fuel element types, which have been and are currently used in German research reactors. The technical development of the cask has been completed, the documents for the transport license as type B(U)F package design and for obtaining the storage license at the interim storage facility of Ahaus have been prepared, submitted to the licensing authorities and to a large degree already evaluated positively. The transport license of the CASTOR trademark MTR 2 has been issued for the shipment of VKTA-contents and FRM II compact fuel elements. (orig.)

  5. Drivers license display system

    Science.gov (United States)

    Prokoski, Francine J.

    1997-01-01

    Carjackings are only one of a growing class of law enforcement problems associated with increasingly violent crimes and accidents involving automobiles plays weapons, drugs and alcohol. Police traffic stops have become increasingly dangerous, with an officer having no information about a vehicle's potentially armed driver until approaching him. There are 15 million alcoholics in the US and 90 percent of them have drivers licenses. Many of them continue driving even after their licenses have ben revoked or suspended. There are thousands of unlicensed truck drivers in the country, and also thousands who routinely exceed safe operating periods without rest; often using drugs in an attempt to stay alert. MIKOS has developed the Drivers License Display Systems to reduce these and other related risks. Although every state requires the continuous display of vehicle registration information on every vehicle using public roads, no state yet requires the display of driver license information. The technology exists to provide that feature as an add-on to current vehicles for nominal cost. An initial voluntary market is expected to include: municipal, rental, and high value vehicles which are most likely to be mis-appropriated. It is anticipated that state regulations will eventually require such systems in the future, beginning with commercial vehicles, and then extending to high risk drivers and eventually all vehicles. The MIKOS system offers a dual-display approach which can be deployed now, and which will utilize all existing state licenses without requiring standardization.

  6. Investigating and Theorizing Discourse during Analogy Writing in Chemistry

    Science.gov (United States)

    Bellocchi, Alberto; Ritchie, Stephen M.

    2011-01-01

    Explanations of the role of analogies in learning science at a cognitive level are made in terms of creating bridges between new information and students' prior knowledge. In this empirical study of learning with analogies in an 11th grade chemistry class, we explore an alternative explanation at the "social" level where analogy shapes…

  7. Nuclear licensing in Slovenia

    International Nuclear Information System (INIS)

    Prah, M.; Spiler, J.; Vojnovic, D.; Pristavec, M.

    1998-01-01

    The article presents the approach to nuclear licensing in Slovenia. The paper describes, the initialization, internal authorization and review process in the Krsko NPP. The overall process includes preparation, internal independent evaluation, the Krsko Operating Committee and the Krsko Safety Committee review and internal approval. In addition, the continuation of the licensing process is discussed which includes independent evaluation by an authorized institution and a regulatory body approval process. This regulatory body approval process includes official hearing of the licensee, communication with the licensee, and final issuance of a license amendment. The internal evaluation, which follows the methodology of US NRC (defined in 10 CFR 50.59 and NUMARC 125) is described. This concept is partially implemented in domestic legislation.(author)

  8. License to Learn

    DEFF Research Database (Denmark)

    Leone, Maria Isabella; Boccardelli, Paolo; Reichstein, Toke

    2016-01-01

    This article introduces the distinction between thin and thick contracts to the investigation of licensing-in as a mechanism for technological learning. Thick contracts include a clause specifying that the licensors are obligated to assist the licensees in assimilating and integrating the technol......This article introduces the distinction between thin and thick contracts to the investigation of licensing-in as a mechanism for technological learning. Thick contracts include a clause specifying that the licensors are obligated to assist the licensees in assimilating and integrating....... Licensees that are more familiar with the licensed technology are in less need of assistance from the licensors to assimilate and integrate the knowledge. However, this substitution effect is neutralized once the hurdle of invention has been overcome, meaning that the licensees have succeeded to ignite...

  9. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  10. Inviting Argument by Analogy: Analogical-Mapping-Based Comparison Activities as a Scaffold for Small-Group Argumentation

    Science.gov (United States)

    Emig, Brandon R.; McDonald, Scott; Zembal-Saul, Carla; Strauss, Susan G.

    2014-01-01

    This study invited small groups to make several arguments by analogy about simple machines. Groups were first provided training on analogical (structure) mapping and were then invited to use analogical mapping as a scaffold to make arguments. In making these arguments, groups were asked to consider three simple machines: two machines that they had…

  11. Design and synthesis of enantiomerically enriched, radiolabeled MK-801 analogs as potential radiotracers for imaging and autoradiographic studies of the NMDA receptor-ion channel complex

    International Nuclear Information System (INIS)

    Eng, W.S.; Burns, H.D.; Gibson, R.E.; Ransom, R.W.; Thorpe, H.; Fioravanit, C.; Britcher, S.F.; Magill, C.A.; Solomon, H.F.; Dannals, R.F.; Wilson, A.A.; Ravert, H.T.; Wagner, H.N.

    1989-01-01

    MK-801 is a potent, non-competitive antagonist for the N-methyl-D-asspartate (NMDA) receptor-ion channel complex. This complex is though to be involved in nerve cell damage in stroke patients when excess calcium is released through the activated channel. A thorough understanding of drug interactions with the NMDA receptor complex could lead to improved therapy for reducing hypoxic-ischemic neuronal injuries in stroke patients. Based on the results of extensive structure-activity studies, the authors have developed several enantiomerically enriched, radiolabeled analogs of MK-801, including: 3-1231-MK-801 for Single Photon Emission Computed tomography (SPECT); 3-1251-MK-801 for in-vivo and in-vitro autoradiography; 8-11C-MeO-MK-801 for Positron Emission Tomography (PET). Details of the synthesis of these radiotracers and their application to both in-vitro and in-vivo studies are described

  12. Towards a universal influenza vaccine: volunteer virus challenge studies in quarantine to speed the development and subsequent licensing.

    Science.gov (United States)

    Oxford, John S

    2013-08-01

    There are now more than 5 experimental vaccine formulations which induce T and B cell immunity towards the internally situated virus proteins matrix (M1 and M2e) and nucleoprotein (NP), and towards stem and stalk regions of the HA which have a shared antigenic structure amongst many of the 17 influenza A virus sub types. Such 'universal vaccines' could be used, at least in theory, as a prophylactic stockpile vaccine for newly emerged epidemic and novel pandemic influenza A viruses or as a supplement to conventional HA/NA vaccines. My own laboratory has approached the problem from the clinical viewpoint by identifying CD4(+) cells which are present in influenza infected volunteers who resist influenza infection. We have established precisely which peptides in M and NP proteins react with these immune CD4 cells. These experimental vaccines induce immunity in animal models but with a single exception no data have been published on protection against influenza virus infection in humans. The efficacy of the latter vaccine is based on vaccinia virus (MVA) as a carrier and was analyzed in a quarantine unit. Given the absence of induced HI antibody in the new universal vaccines a possible licensing strategy is a virus challenge model in quarantine whereby healthy volunteers can be immunized with the new vaccine and thereafter deliberately infected and clinical signs recorded alongside quantities of virus excreted and compared with unvaccinated controls. © 2013 The British Pharmacological Society.

  13. Analogy, Explanation, and Proof

    Directory of Open Access Journals (Sweden)

    John eHummel

    2014-11-01

    Full Text Available People are habitual explanation generators. At its most mundane, our propensity to explain allows us to infer that we should not drink milk that smells sour; at the other extreme, it allows us to establish facts (e.g., theorems in mathematical logic whose truth was not even known prior to the existence of the explanation (proof. What do the cognitive operations underlying the (inductive inference that the milk is sour have in common with the (deductive proof that, say, the square root of two is irrational? Our ability to generate explanations bears striking similarities to our ability to make analogies. Both reflect a capacity to generate inferences and generalizations that go beyond the featural similarities between a novel problem and familiar problems in terms of which the novel problem may be understood. However, a notable difference between analogy-making and explanation-generation is that the former is a process in which a single source situation is used to reason about a single target, whereas the latter often requires the reasoner to integrate multiple sources of knowledge. This small-seeming difference poses a challenge to the task of marshaling our understanding of analogical reasoning in the service of understanding explanation. We describe a model of explanation, derived from a model of analogy, adapted to permit systematic violations of this one-to-one mapping constraint. Simulation results demonstrate that the resulting model can generate explanations for novel explananda and that, like the explanations generated by human reasoners, these explanations vary in their coherence.

  14. Are Scientific Analogies Metaphors?

    Science.gov (United States)

    1981-02-01

    and healer Paracelsus , writing within a century of Kepler and Galileo: what, then, is the short and easy way whereby Sol (gold) and Luna (silver) can be...planets again receive a body and life and live as before. Take this body from the life and the earth. Keep it. It is Sol and Luna. 30 Aim ( Paracelsus ...Rutherford analogy, even as known at the time. Instead of using a mutually constraining system of base relationships Paracelsus applies new relations: e.g

  15. Improving the Business Trade Licensing Reform Environment

    OpenAIRE

    Gamser, Matthew

    2003-01-01

    This case study of Kenyan business trade licensing shows that red-tape costs can be cut if reform is championed strongly and there is a strong case in terms of costs and benefits. The reform of business registration, trade licensing and other business entry procedures is a cost effective and progressive way to promote indigenous private sector development. But, reform needs more than good cost-benefit analysis and legal drafting; it also requires building constituencies and continuous advocacy.

  16. IN-SITU PROBING OF RADIATION-INDUCED PROCESSING OF ORGANICS IN ASTROPHYSICAL ICE ANALOGS-NOVEL LASER DESORPTION LASER IONIZATION TIME-OF-FLIGHT MASS SPECTROSCOPIC STUDIES

    Energy Technology Data Exchange (ETDEWEB)

    Gudipati, Murthy S.; Yang Rui, E-mail: gudipati@jpl.nasa.gov, E-mail: ryang73@ustc.edu [University of Maryland (United States)

    2012-09-01

    Understanding the evolution of organic molecules in ice grains in the interstellar medium (ISM) under cosmic rays, stellar radiation, and local electrons and ions is critical to our understanding of the connection between ISM and solar systems. Our study is aimed at reaching this goal of looking directly into radiation-induced processing in these ice grains. We developed a two-color laser-desorption laser-ionization time-of-flight mass spectroscopic method (2C-MALDI-TOF), similar to matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectroscopy. Results presented here with polycyclic aromatic hydrocarbon (PAH) probe molecules embedded in water-ice at 5 K show for the first time that hydrogenation and oxygenation are the primary chemical reactions that occur in astrophysical ice analogs when subjected to Ly{alpha} radiation. We found that hydrogenation can occur over several unsaturated bonds and the product distribution corresponds to their stabilities. Multiple hydrogenation efficiency is found to be higher at higher temperatures (100 K) compared to 5 K-close to the interstellar ice temperatures. Hydroxylation is shown to have similar efficiencies at 5 K or 100 K, indicating that addition of O atoms or OH radicals to pre-ionized PAHs is a barrierless process. These studies-the first glimpses into interstellar ice chemistry through analog studies-show that once accreted onto ice grains PAHs lose their PAH spectroscopic signatures through radiation chemistry, which could be one of the reason for the lack of PAH detection in interstellar ice grains, particularly the outer regions of cold, dense clouds or the upper molecular layers of protoplanetary disks.

  17. Component Processes in Analogical Reasoning

    Science.gov (United States)

    Sternberg, Robert J.

    1977-01-01

    Describes alternative theoretical positions regarding (a) the component information processes used in analogical reasoning and (b) strategies for combining these processes. Also presents results from three experiments on analogical reasoning. (Author/RK)

  18. Children's analogical reasoning about natural phenomena.

    Science.gov (United States)

    Pauen, S; Wilkening, F

    1997-10-01

    This report investigates children's analogical reasoning in a physics task, using an analogy generated by the children rather than by the experimenter. A total of 127 elementary school children took part in three related studies. Children learned to predict the behavior of a balance scale. Later, they were asked to solve a force interaction problem. Two versions of the balance scale training were devised: version A suggested an incorrect solution to the target problem (negative analogy), and version B suggested a correct solution to the target problem (positive analogy). In Study 1, 9- to 10-year-olds showed spontaneous transfer in both training conditions. In Study 2, 7-year-olds did not show any transfer in the positive analogy condition. Study 3 revealed that the lack of transfer in younger children was not due to a failure either to notice the analogy or to perform the mapping. Instead, 7-year-olds transferred only selected aspects of the correct solution. Copyright 1997 Academic Press.

  19. Study on radiolabeling of 1, 2, 3-triazole analogs with fac-[188Re(CO)3(H2O)3]+ via click chemistry

    International Nuclear Information System (INIS)

    Wang Cheng; Yin Jilin; Zhou Zheng; Zhou Wei; Zhang Lan

    2013-01-01

    Click chemistry was used to study on radiolabeling of 1, 2, 3-triazole analogs with. fac-[ 188 Re(CO) 3 (H 2 O) 3 ] + . CuSO 4 /L-sodium ascorbate was chosen as the catalyst system, three terminal alkynes were conjugated with two different azides respectively, and then the new prepared fac-[ 188 Re(CO) 3 (H 2 O) 3 ] + was coordinated to the six triazoles. The results showed that the radiochemical yields (RCY) of the conjugation of fac-[ 188 Re(CO) 3 ] + with six triazoles were over 90%, and the triazoles showed high stability in phosphate-buffered saline and new-born calf serum. The preliminary biological evaluation results showed that the new 188 Re-labeling method via click chemistry could have general application in labeling bioactive molecules in high radiochemical yield and high specific activity for further SPECT research. (authors)

  20. Inductive, Analogical, and Communicative Generalization

    Directory of Open Access Journals (Sweden)

    Adri Smaling

    2003-03-01

    Full Text Available Three forms of inductive generalization - statistical generalization, variation-based generalization and theory-carried generalization - are insufficient concerning case-to-case generalization, which is a form of analogical generalization. The quality of case-to-case generalization needs to be reinforced by setting up explicit analogical argumentation. To evaluate analogical argumentation six criteria are discussed. Good analogical reasoning is an indispensable support to forms of communicative generalization - receptive and responsive (participative generalization — as well as exemplary generalization.

  1. Novel acyclonucleoside analog bearing a 1,2,4-triazole–Schiff base: Synthesis, characterization and analytical studies using square wave-adsorptive stripping voltammetry and HPLC

    Directory of Open Access Journals (Sweden)

    Ali F. Alghamdi

    2017-09-01

    Full Text Available New acyclonucleoside analogs tethered by a 1,2,4-triazole scaffold were synthesized through the condensation of 4-amino-5-(2-phenyleth-1-yl-2,4-dihydro-3H-1,2,4-triazole-3-thione (2 with benzaldehyde followed by the alkylation of the resulting Schiff base (3with 2-bromoethanol, 3-chloropropanol and/or 3-chloropropan-1,2-diol. Voltammetric studies were carried out for the analysis of 1 × 10−6 mol L−1 of the newly synthesized acyclonucleoside analogs (4–6 using square wave-adsorptive stripping voltammetry (SW-AdSV. The sharp voltammetric peak and high reduction current were recorded using a Britton–Robinson B–R pH 10 buffer at Ep = −1250 mV on the hanging mercury drop surface (HMDE and Ag/AgCl reference electrode. Several experimental conditions were studied, such as the supporting electrolytes, the pH, and the accumulation time, as well as the potential, the scan rate, the frequency and the step potential for 4-benzylideneamino-5-(2-phenyleth-1-yl-3-[(2,3-dihydroxyprop-1-ylthio]-1,2,4-triazole (6. The analytical performance of the voltammetric technique was investigated through the analysis of the calibration curve, the detection limit, the recovery and the stability. The voltammetric analytical applications were evaluated by the recovery of compound (6 in the urine and plasma samples. The HPLC technique was also applied for the separation of compound (6 from interference using a C-18 (5 μm column with UV detection at 254 nm.

  2. Licensing the Sun

    Science.gov (United States)

    Demski, Jennifer

    2013-01-01

    The University of San Diego (USD) and Point Loma Nazarene University (PLNU) are licensing the sun. Both California schools are generating solar power on campus without having to sink large amounts of capital into equipment and installation. By negotiating power purchasing agreements (PPAs) with Amsolar and Perpetual Energy Systems, respectively,…

  3. Digital Content Licensing

    DEFF Research Database (Denmark)

    Schwemer, Sebastian Felix

    -legislative) initiatives, which support the facilitation of multi-territorial licensing and cross-border access to content. It investigates the regulation of two online markets, which have recently been subject to scrutiny by the EU institutions: the audiovisual and the music sector, both addressed by ex ante sector...

  4. Biography and License

    Science.gov (United States)

    Novitz, David

    2001-01-01

    What are the moral limits of artistic license? A strong case can be made for the view that there are none; that in viewing works of art people should resist ethical criticism, and, "a fortiori," resist moral strictures on the artist's inventiveness. This view has recently been defended by Richard Posner, who argues that people should not expect…

  5. Hegel, Analogy, and Extraterrestrial Life

    Science.gov (United States)

    Ross, Joseph T.

    Georg Wilhelm Friedrich Hegel rejected the possibility of life outside of the Earth, according to several scholars of extraterrestrial life. Their position is that the solar system and specifically the planet Earth is the unique place in the cosmos where life, intelligence, and rationality can be. The present study offers a very different interpretation of Hegel's statements about the place of life on Earth by suggesting that, although Hegel did not believe that there were other solar systems where rationality is present, he did in fact suggest that planets in general, not the Earth exclusively, have life and possibly also intelligent inhabitants. Analogical syllogisms are superficial, according to Hegel, insofar as they try to conclude that there is life on the Moon even though there is no evidence of water or air on that body. Similar analogical arguments for life on the Sun made by Johann Elert Bode and William Herschel were considered by Hegel to be equally superficial. Analogical arguments were also used by astronomers and philosophers to suggest that life could be found on other planets in our solar system. Hegel offers no critique of analogical arguments for life on other planets, and in fact Hegel believed that life would be found on other planets. Planets, after all, have meteorological processes and therefore are "living" according to his philosophical account, unlike the Moon, Sun, and comets. Whereas William Herschel was already finding great similarities between the Sun and the stars and had extended these similarities to the property of having planets or being themselves inhabitable worlds, Hegel rejected this analogy. The Sun and stars have some properties in common, but for Hegel one cannot conclude from these similarities to the necessity that stars have planets. Hegel's arguments against the presence of life in the solar system were not directed against other planets, but rather against the Sun and Moon, both of which he said have a different

  6. Use of analogy in learning physics: The role of representations

    Directory of Open Access Journals (Sweden)

    Noah D. Finkelstein

    2006-07-01

    Full Text Available Previous studies have demonstrated that analogies can promote student learning in physics and can be productively taught to students to support their learning, under certain conditions. We build on these studies to explore the use of analogy by students in a large introductory college physics course. In the first large-scale study of its kind, we demonstrate that different analogies can lead to varied student reasoning. When different analogies were used to teach electromagnetic (EM waves, we found that students explicitly mapped characteristics either of waves on strings or sound waves to EM waves, depending upon which analogy students were taught. We extend these results by investigating how students use analogies. Our findings suggest that representational format plays a key role in the use of analogy.

  7. 31 CFR 596.309 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.309 Specific license. The term specific license means any license or...

  8. Regulatory requirements for replacement of analog systems with digital upgrades

    International Nuclear Information System (INIS)

    Loeser, P.J.

    1993-01-01

    This paper reviews briefly the regulatory guidelines which must be met in order to replace analog systems in nuclear power plants with digital systems. There is a move to do such replacements for a number of reasons: analog systems are aging, and showing considerable drift; few vendors manufacture analog systems today; support and parts are hard to get; digital systems provide flexibility. There is a safety concern however about undesirable and unpredictable effects to digital safety equipment due to plant transients, accidents, post-accident condition, and EMI/RF environmental interferences. License holders must comply with the requirements of 10 C.F.R. 50.59, which deals with safety concerns with respect to any changes to operating plants which may have an impact on the safety of the plant. NRC staff is taking the position that all digital upgrades will require an evaluation under this regulation

  9. Analog design centering and sizing

    CERN Document Server

    Graeb, Helmut E

    2007-01-01

    Here is a compendium of fundamental problem formulations of analog design centering and sizing. It provides a differentiated knowledge about the many tasks of analog design centering and sizing. In particular, coverage formulates the worst-case problem. The book stands at the interface between process technology and design technology, detailing how the two are required to reach a solution. It presents a mathematically founded description based on numerical optimization and statistics. This volume will enable analog and mixed-signal designers to assess CAD solution methods that are presented to them as well as help developers of analog CAD tools to formulate and develop solution approaches for analog design centering and sizing.

  10. ESD analog circuits and design

    CERN Document Server

    Voldman, Steven H

    2014-01-01

    A comprehensive and in-depth review of analog circuit layout, schematic architecture, device, power network and ESD design This book will provide a balanced overview of analog circuit design layout, analog circuit schematic development, architecture of chips, and ESD design.  It will start at an introductory level and will bring the reader right up to the state-of-the-art. Two critical design aspects for analog and power integrated circuits are combined. The first design aspect covers analog circuit design techniques to achieve the desired circuit performance. The second and main aspect pres

  11. Use of insulin and insulin analogs and risk of cancer - systematic review and meta-analysis of observational studies

    DEFF Research Database (Denmark)

    Karlstad, Oystein; Starup-Linde, Jacob; Vestergaard, Peter

    2013-01-01

    exogenous insulin. Comparison: Diabetes patients with or without use of antidiabetic drugs. OUTCOME: Any incident cancer. STUDY DESIGN: Cohort and case-control studies. RESULTS: 42 eligible studies examined risk of any cancer and 27 site-specific cancers. Results of individual studies were heterogeneous......BACKGROUND: An association of insulin use and risk of cancer has been reported but evidence is conflicting and methodological issues have been identified. OBJECTIVE: To summarize results regarding insulin use and cancer risk by a systematic review and meta-analysis of cohort and case......-control studies examining risk of cancer associated with insulin use in patients with diabetes. DATA SOURCES: Systematic literature search in 5 databases: PubMed, Embase, Web of Science, Scopus and Cochrane Library. STUDY ELIGIBILITY CRITERIA (PICOS): POPULATION: diabetes patients. EXPOSURE: Users of any...

  12. Pathways linking car transport for young adults and the public health in Northern Ireland: a qualitative study to inform the evaluation of graduated driver licensing.

    Science.gov (United States)

    Christie, Nicola; Steinbach, Rebecca; Green, Judith; Mullan, M Patricia; Prior, Lindsay

    2017-06-07

    Novice drivers are at relatively high risk of road traffic injury. There is good evidence that Graduated Driving Licensing (GDL) schemes reduce collisions rates, by reducing exposure to risk and by extending learning periods. Legislation for a proposed scheme in Northern Ireland was passed in 2016, providing an opportunity for future evaluation of the full public health impacts of a scheme in a European context within a natural experiment. This qualitative study was designed to inform the logic model for such an evaluation, and provide baseline qualitative data on the role of private cars in health and wellbeing. Nine group interviews with young people aged 16-23 (N = 43) and two group interviews with parents of young people (N = 8) were conducted in a range of settings in Northern Ireland in 2015. Data were analysed using thematic content analysis. Informal car-pooling within and beyond households led to routine expectations of lift provision and uptake. Experiences of risky driving situations were widespread. In rural areas, extensive use of farm vehicles for transport needs meant many learner drivers had both early driving experience and expectations that legislation may have to be locally adapted to meet social needs. Cars were used as a site for socialising, as well as essential means of transport. Alternative modes (public transport, walking and cycling) were held in low esteem, even where available. Recall of other transport-related public health messages and parents' existing use of GDL-type restrictions suggested GDL schemes were acceptable in principle. There was growing awareness and use of in-car technologies (telematics) used by insurance companies to reward good driving. Key issues to consider in evaluating the broader public health impact of GDL will include: changes in injury rates for licensed car occupants and other populations and modes; changes in exposure to risk in the licensed and general population; and impact on transport exclusion. We

  13. Pathways linking car transport for young adults and the public health in Northern Ireland: a qualitative study to inform the evaluation of graduated driver licensing

    Directory of Open Access Journals (Sweden)

    Nicola Christie

    2017-06-01

    Full Text Available Abstract Background Novice drivers are at relatively high risk of road traffic injury. There is good evidence that Graduated Driving Licensing (GDL schemes reduce collisions rates, by reducing exposure to risk and by extending learning periods. Legislation for a proposed scheme in Northern Ireland was passed in 2016, providing an opportunity for future evaluation of the full public health impacts of a scheme in a European context within a natural experiment. This qualitative study was designed to inform the logic model for such an evaluation, and provide baseline qualitative data on the role of private cars in health and wellbeing. Methods Nine group interviews with young people aged 16–23 (N = 43 and two group interviews with parents of young people (N = 8 were conducted in a range of settings in Northern Ireland in 2015. Data were analysed using thematic content analysis. Results Informal car-pooling within and beyond households led to routine expectations of lift provision and uptake. Experiences of risky driving situations were widespread. In rural areas, extensive use of farm vehicles for transport needs meant many learner drivers had both early driving experience and expectations that legislation may have to be locally adapted to meet social needs. Cars were used as a site for socialising, as well as essential means of transport. Alternative modes (public transport, walking and cycling were held in low esteem, even where available. Recall of other transport-related public health messages and parents’ existing use of GDL-type restrictions suggested GDL schemes were acceptable in principle. There was growing awareness and use of in-car technologies (telematics used by insurance companies to reward good driving. Conclusions Key issues to consider in evaluating the broader public health impact of GDL will include: changes in injury rates for licensed car occupants and other populations and modes; changes in exposure to risk in the

  14. Studies on the lysis of red cells and bimolecular lipid leaflets by synthetic lysolecithins, lecithins and structural analogs

    NARCIS (Netherlands)

    Reman, F.C.; Demel, R.A.; Gier, J. de; Deenen, L.L.M. van; Eibl, H.; Westphal, O.

    The results obtained in this study show a great influence of the acyl chain on the lytic behavior of lysolecithins and lecithins. 1. 1.The lysolecithins studied, ranged in acyl chain length from 10 to 18 carbon atoms.The palmitoyl- and stearoylderivatives were found to be the most active, whereas

  15. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    1982-04-01

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis

  16. How to Reform Business Licenses

    OpenAIRE

    International Finance Corporation; World Bank

    2010-01-01

    Reforming business licenses is part of a suite of products delivered by the World Bank group's investment climate advisory services, under the business operations practice. The approach to reforms highlighted in this handbook fits into the broader policy framework for business licensing reform and simplification. The framework paper provides the context for business licensing practices; es...

  17. Use of Insulin and Insulin Analogs and Risk of Cancer — Systematic Review and Meta-Analysis of Observational Studies

    Science.gov (United States)

    Karlstad, Øystein; Starup-Linde, Jacob; Vestergaard, Peter; Hjellvik, Vidar; T. Bazelier, Marloes; K. Schmidt, Marjanka; Andersen, Morten; Auvinen, Anssi; Haukka, Jari; Furu, Kari; de Vries, Frank; L. de Bruin, Marie

    2014-01-01

    Background: An association of insulin use and risk of cancer has been reported but evidence is conflicting and methodological issues have been identified. Objective: To summarize results regarding insulin use and cancer risk by a systematic review and meta-analysis of cohort and case-control studies examining risk of cancer associated with insulin use in patients with diabetes. Data Sources: Systematic literature search in 5 databases: PubMed, Embase, Web of Science, Scopus and Cochrane Library. Study Eligibility Criteria (PICOS): Population: diabetes patients. Exposure: Users of any exogenous insulin. Comparison: Diabetes patients with or without use of antidiabetic drugs. Outcome: Any incident cancer. Study Design: Cohort and case-control studies. Results: 42 eligible studies examined risk of any cancer and 27 site-specific cancers. Results of individual studies were heterogeneous. Meta-analyses were significant for: Insulin vs No Insulin: Increased risk for pancreas, liver, kidney, stomach and respiratory cancer, decreased risk for prostate cancer. Insulin vs Non-Insulin Antidiabetics: Increased risk for any, pancreatic and colorectal cancer. Glargine vs Non-Glargine Insulin: Increased risk for breast cancer, decreased risk for colon cancer. Limitations: Few studies available for most cancer sites and exposure contrasts, and few assess effect of dose and duration of exposure. Methodological issues in several studies. Availability of confounders. Conclusions: Insulin use was associated with risk of cancer at several sites. Cautious interpretation of results is warranted as methodological issues and limitations in several of the included studies have been identified. Choice of study design may have a profound effect on estimated cancer risk. PMID:24215311

  18. Albert Einstein, Analogizer Extraordinaire

    CERN Multimedia

    CERN. Geneva

    2007-01-01

    Where does deep insight in physics come from? It is tempting to think that it comes from the purest and most precise of reasoning, following ironclad laws of thought that compel the clear mind completely rigidly. And yet the truth is quite otherwise. One finds, when one looks closely at any major discovery, that the greatest of physicists are, in some sense, the most crazily daring and irrational of all physicists. Albert Einstein exemplifies this thesis in spades. In this talk I will describe the key role, throughout Albert Einstein's fabulously creative life, played by wild guesses made by analogy lacking any basis whatsoever in pure reasoning. In particular, in this year of 2007, the centenary of 1907, I will describe how over the course of two years (1905 through 1907) of pondering, Einstein slowly came, via analogy, to understand the full, radical consequences of the equation that he had first discovered and published in 1905, arguably the most famous equation of all time: E = mc2.

  19. A meta-analytic review of moral licensing.

    Science.gov (United States)

    Blanken, Irene; van de Ven, Niels; Zeelenberg, Marcel

    2015-04-01

    Moral licensing refers to the effect that when people initially behave in a moral way, they are later more likely to display behaviors that are immoral, unethical, or otherwise problematic. We provide a state-of-the-art overview of moral licensing by conducting a meta-analysis of 91 studies (7,397 participants) that compare a licensing condition with a control condition. Based on this analysis, the magnitude of the moral licensing effect is estimated to be a Cohen's d of 0.31. We tested potential moderators and found that published studies tend to have larger moral licensing effects than unpublished studies. We found no empirical evidence for other moderators that were theorized to be of importance. The effect size estimate implies that studies require many more participants to draw solid conclusions about moral licensing and its possible moderators. © 2015 by the Society for Personality and Social Psychology, Inc.

  20. About Some Aspects of License Contracts Legal Regulation

    Directory of Open Access Journals (Sweden)

    Ekaterina A. Sviridova

    2015-06-01

    Full Text Available Over the past few years subjects of a civil turn estimated possibilities of use of the intellectual rights for results of intellectual activity and means of an individualization equated to them in business activity and began "to commercialize" intellectual property actively. In the present article the author investigates some aspects of legal regulation of license contracts. In the conclusion the author notes that, rules of law of intellectual property are independent, the rules regulating contracts on alienation of an exclusive right and license contracts are taken out for the part framework the second Civil Code of the Russian Federation regulating questions of the contract of donation and therefore is inadmissible to apply as analogy of the law to the contract on gratuitous alienation of an exclusive right and the license contract of norm on the contract of donation.

  1. License to Critique

    DEFF Research Database (Denmark)

    Christensen, Lars Thøger; Morsing, Mette; Thyssen, Ole

    2017-01-01

    on a research tradition that views communication as constitutive of organization to emphasize the significance of communicative mechanisms that stimulate organizational openness in the application of standards. With the notion of “license to critique,” we present a managerial philosophy designed to involve...... managers and employees, mobilize and develop their knowledge about sustainability and bring it forward for the benefit of both the organization and the environment....

  2. Problems of licensing

    OpenAIRE

    Heřman, Karel

    2009-01-01

    This work concerns with possibilities of licensing. There are mentioned advantages and disadvantages of particular models. Further on, the prediction of future situation in the IT market, new techniques, trends and reasons of these changes are introduced. Work addresses to both types of software -- proprietary software and Open Source software. Next part of work deals with software piracy and problems, which are connected with it. In second part of the work are theoretical knowledge converted...

  3. A bilateral frontoparietal network underlies visuospatial analogical reasoning.

    Science.gov (United States)

    Watson, Christine E; Chatterjee, Anjan

    2012-02-01

    Our ability to reason by analogy facilitates problem solving and allows us to communicate ideas efficiently. In this study, we examined the neural correlates of analogical reasoning and, more specifically, the contribution of rostrolateral prefrontal cortex (RLPFC) to reasoning. This area of the brain has been hypothesized to integrate relational information, as in analogy, or the outcomes of subgoals, as in multi-tasking and complex problem solving. Using fMRI, we compared visuospatial analogical reasoning to a control task that was as complex and difficult as the analogies and required the coordination of subgoals but not the integration of relations. We found that analogical reasoning more strongly activated bilateral RLPFC, suggesting that anterior prefrontal cortex is preferentially recruited by the integration of relational knowledge. Consistent with the need for inhibition during analogy, bilateral, and particularly right, inferior frontal gyri were also more active during analogy. Finally, greater activity in bilateral inferior parietal cortex during the analogy task is consistent with recent evidence for the neural basis of spatial relation knowledge. Together, these findings indicate that a network of frontoparietal areas underlies analogical reasoning; we also suggest that hemispheric differences may emerge depending on the visuospatial or verbal/semantic nature of the analogies. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Elucidating the neurotoxic effects of MDMA and its analogs.

    Science.gov (United States)

    Karuppagounder, Senthilkumar S; Bhattacharya, Dwipayan; Ahuja, Manuj; Suppiramaniam, Vishnu; Deruiter, Jack; Clark, Randall; Dhanasekaran, Muralikrishnan

    2014-04-17

    There is a rapid increase in the use of methylenedioxymethamphetamine (MDMA) and its structural congeners/analogs globally. MDMA and MDMA-analogs have been synthesized illegally in furtive dwellings and are abused due to its addictive potential. Furthermore, MDMA and MDMA-analogs have shown to have induced several adverse effects. Hence, understanding the mechanisms mediating this neurotoxic insult of MDMA-analogs is of immense importance for the public health in the world. We synthesized and investigated the neurotoxic effects of MDMA and its analogs [4-methylenedioxyamphetamine (MDA), 2, 6-methylenedioxyamphetamine (MDMA), and N-ethyl-3, 4-methylenedioxyamphetamine (MDEA)]. The stimulatory or the dopaminergic agonist effects of MDMA and MDMA-analogs were elucidated using the established 6-hydroxydopamine lesioned animal model. Additionally, we also investigated the neurotoxic mechanisms of MDMA and MDMA-analogs on mitochondrial complex-I activity and reactive oxygen species generation. MDMA and MDMA-analogs exhibited stimulatory activity as compared to amphetamines and also induced several behavioral changes in the rodents. MDMA and MDMA-analogs enhanced the reactive oxygen generation and inhibited mitochondrial complex-I activity which can lead to neurodegeneration. Hence the mechanism of neurotoxicity, MDMA and MDMA-analogs can enhance the release of monoamines, alter the monoaminergic neurotransmission, and augment oxidative stress and mitochondrial abnormalities leading to neurotoxicity. Thus, our study will help in developing effective pharmacological and therapeutic approaches for the treatment of MDMA and MDMA-analog abuse. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Use of insulin and insulin analogs and risk of cancer - systematic review and meta-analysis of observational studies

    DEFF Research Database (Denmark)

    Karlstad, Oystein; Starup-Linde, Jacob; Vestergaard, Peter

    2013-01-01

    . Meta-analyses were significant for: Insulin vs No Insulin: Increased risk for pancreas, liver, kidney, stomach and respiratory cancer, decreased risk for prostate cancer. Insulin vs Non-Insulin Antidiabetics: Increased risk for any, pancreatic and colorectal cancer. Glargine vs Non-Glargine Insulin......BACKGROUND: An association of insulin use and risk of cancer has been reported but evidence is conflicting and methodological issues have been identified. OBJECTIVE: To summarize results regarding insulin use and cancer risk by a systematic review and meta-analysis of cohort and case......-control studies examining risk of cancer associated with insulin use in patients with diabetes. DATA SOURCES: Systematic literature search in 5 databases: PubMed, Embase, Web of Science, Scopus and Cochrane Library. STUDY ELIGIBILITY CRITERIA (PICOS): POPULATION: diabetes patients. EXPOSURE: Users of any...

  6. Working hours, sleep, salivary cortisol, fatigue and neuro-behavior during Mars analog mission: five crews study.

    Science.gov (United States)

    Rai, Balwant; Foing, Bernard H; Kaur, Jasdeep

    2012-05-16

    The buoyancy of humans in exploring extreme space environments has been established during missions to the moon. Long duration missions like mission to Mars however, requires humans to adapt to systemic and complex environments beyond the human body's capacity. Astronauts will encounter both physiological and psychological extremes during this trip. Very few studies are conducted on effect of long duration work and sleepiness on cognitive performance. So, this study was planned to find out effects of leadership responsibility, sleepiness and long duration working hours on cognitive performance. The 30 members (leadership: normal; 10:20) were selected from MDRS crews (Mars Desert Research Station, USA). Neurobehavioral test performance, self-ratings of fatigue and sleepiness, and salivary cortisol levels were evaluated during first day, mid and end day of mission. The leadership group did not show any signs of reduced test performance, even in elevated fatigue and sleepiness. The leadership group had faster reaction times on end of mission as compared to first and after 7 day of mission. Salivary cortisol levels were significantly higher in leadership group as compared to normal group. The results suggest that long duration work and sleepiness does not affect the cognitive performance of crew member. Further study is required while taking into account all factors and large sample size to prove this fact. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  7. Nuclear power plant licensing: opportunities for improvement

    International Nuclear Information System (INIS)

    1977-06-01

    On April 20, 1977, the Commission directed that recently completed licensing actions be reviewed by the staff for the purpose of identifying ways to improve the effectiveness and efficiency of NRC nuclear power plant licensing activities. This report summarizes the results of a study undertaken by an internal ad hoc Study Group established in response to that directive. The Study Group limited its considerations to safety and environmental review activities. The background, scope, assumptions and objectives of the study are discussed. A prime assumption of this study was that improvements in the efficiency should not be permitted to reduce the current quality achieved in the licensing process. This consideration underlies the conclusions and recommendations of the study

  8. Potential of Probing the Lunar Regolith using Rover-Mounted Ground Penetrating Radar: Moses Lake Dune Field Analog Study

    Science.gov (United States)

    Horz, F.; Heggy, E.; Fong, T.; Kring, D.; Deans, M.; Anglade, A.; Mahiouz, K.; Bualat, M.; Lee, P.; Bluethmann, W.

    2009-01-01

    Probing radars have been widely recognized by the science community to be an efficient tool to explore lunar subsurface providing a unique capability to address several scientific and operational issues. A wideband (200 to 1200 MHz) Ground Penetrating Radar (GPR) mounted on a surface rover can provide high vertical resolution and probing depth from few tens of centimeters to few tens of meters depending on the sounding frequency and the ground conductivity. This in term can provide a better understand regolith thickness, elemental iron concentration (including ilmenite), volatile presence, structural anomalies and fracturing. All those objectives are of important significance for understanding the local geology and potential sustainable resources for future landing sites in particular exploring the thickness, structural heterogeneity and potential volatiles presence in the lunar regolith. While the operation and data collection of GPR is a straightforward case for most terrestrial surveys, it is a challenging task for remote planetary study especially on robotic platforms due to the complexity of remote operation in rough terrains and the data collection constrains imposed by the mechanical motion of the rover and limitation in data transfer. Nevertheless, Rover mounted GPR can be of great support to perform systematic subsurface surveys for a given landing site as it can provide scientific and operational support in exploring subsurface resources and sample collections which can increase the efficiency of the EVA activities for potential human crews as part of the NASA Constellation Program. In this study we attempt to explore the operational challenges and their impact on the EVA scientific return for operating a rover mounted GPR in support of potential human activity on the moon. In this first field study, we mainly focused on the ability of GPR to support subsurface sample collection and explore shallow subsurface volatiles.

  9. Analog System of Detonations with Loss and Stability of the Analog System

    Science.gov (United States)

    Sun, Yuanxiang; Wang, Cheng; Group of Computationa Fluid Dynamics Team

    2017-06-01

    Analog system of detonation is a simplified model of the Euler system. Analog system removes unnecessary details of the Euler system and reduces mathematical difficulty Analog system with losses and reaction mechanism that applicable for condensed-phase detonation is studied to examine whether the analog system in this paper is valid Details are as follows: 1. The relationship of detonation velocity vs. loss parameter is analytically solved, and a minimal state-dependence of the reaction rate n required for this relationship to exhibit a critical behavior (i.e., a turning point) is examined The results agree with the limits which derived from Euler system. 2. Normal-mode method is used to study the stability of the analog system. A radiation (closure) condition is derived and applied at the end of the reaction zone. An analysis is performed to investigate whether the ideal, steady-state detonation can keep stable to small perturbations 3. Because analog system with loss can be more unstable than the ideal one. An numerical simulation is used to examine the detonation stability near the loss limits. The results above show that the analog system is basically valid for condensed-phase detonation.

  10. Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl ethyl cyclohexanol analogs as potential microbial agents

    Directory of Open Access Journals (Sweden)

    Vinay Mahyavanshi

    2017-02-01

    Full Text Available A novel series of Schiff bases 4a–n was prepared from 2-hydrazinyl-N-(2-(1-hydroxycyclohexyl-2-(4-methoxyphenyl ethylacetamide. Thiazolidinone 5a–n derivatives were prepared from the reaction of Schiff base and thioglycolic acid. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and Mass spectral data. All the compounds were screened against different strains of bacteria and fungi. These active compounds impelled us to study their antitubercular activity. Compounds 4b, 5a, 5b, 5d, 5e, 5f, 5k, 5l and 5n emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 5k showed better antitubercular activity compared to Rifampicin.

  11. The Moon as a recorder of organic evolution in the early solar system: a lunar regolith analog study.

    Science.gov (United States)

    Matthewman, Richard; Court, Richard W; Crawford, Ian A; Jones, Adrian P; Joy, Katherine H; Sephton, Mark A

    2015-02-01

    The organic record of Earth older than ∼3.8 Ga has been effectively erased. Some insight is provided to us by meteorites as well as remote and direct observations of asteroids and comets left over from the formation of the Solar System. These primitive objects provide a record of early chemical evolution and a sample of material that has been delivered to Earth's surface throughout the past 4.5 billion years. Yet an effective chronicle of organic evolution on all Solar System objects, including that on planetary surfaces, is more difficult to find. Fortunately, early Earth would not have been the only recipient of organic matter-containing objects in the early Solar System. For example, a recently proposed model suggests the possibility that volatiles, including organic material, remain archived in buried paleoregolith deposits intercalated with lava flows on the Moon. Where asteroids and comets allow the study of processes before planet formation, the lunar record could extend that chronicle to early biological evolution on the planets. In this study, we use selected free and polymeric organic materials to assess the hypothesis that organic matter can survive the effects of heating in the lunar regolith by overlying lava flows. Results indicate that the presence of lunar regolith simulant appears to promote polymerization and, therefore, preservation of organic matter. Once polymerized, the mineral-hosted newly formed organic network is relatively protected from further thermal degradation. Our findings reveal the thermal conditions under which preservation of organic matter on the Moon is viable.

  12. Study of nuclear reactions and analog isobar states in the system He8 + p for low energy with the help of MAYA active target

    International Nuclear Information System (INIS)

    Demonchy, Ch.E.

    2003-12-01

    With the resent improvements in the field of exotics beams, and specially with the SPIRAL facility at GANIL, we were able to study He 9 shell inversion already known for Be 11 and Li 10 , which are two members of the N=7 family. A new detector was developed and also the software tools for the data analysis. This detector is at the same time the target (active-target) and is called MAYA. The He 9 was studied by determining the properties of its isobaric analogue states in Li 9 . The characteristics of the IAS (isomeric analog state) states were determined by an analysis of the resonances in the elastic scattering cross section for He 8 + p from 2 up to 3.9 MeV/n. A study of (p,d) and (p,t) reactions was done too, in this domain of energy. By comparing the experimental results with calculations, an assignation of spin and parity for two states in He 9 was possible. (author)

  13. Habitability: where lo look for life? Habitability Index Earth analogs to study Mars and Europa`s habitability

    Science.gov (United States)

    Gomez, F.; Amils, R.; Gomez-Elvira, J.

    2010-12-01

    afford its comprehension (Gómez F. et al., 2010). We are reporting here some preliminary studies about endolithic niches inside salt deposits used by phototrophs for taking advantage of sheltering particular light wavelengths. These acidic salts deposits located in Río Tinto shelter life forms which are difficult to localize by eye. Molecular ecology techniques are needed for its localization and study. We also are reporting here some results about bacterial survivability in Mars simulation conditions (Gómez F. et al., 2010). Final objective of this work is the development of the Habitability Index. Bibliography Fernández-Remolar, D. et al., Planetary and Space Science 52 (2004) 239 - 248 Gómez, F. et al., Icarus 191 (2007) 352-359. Gómez, F. et al. Icarus (2010), doi:10.1016/j.icarus.2010.05.027 Acknowledgments This study was funded by the project ESP2006-06640 from Spanish Ministry of Education and Science and FEDER funds from European Community.

  14. UDP-GlcNAc Analogs as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational and Biological Studies.

    Science.gov (United States)

    Merino, Pedro; Ghirardello, Mattia; Perrone, Daniela; Chinaglia, Nicola; Sadaba, David; Delso, Ignacio; Tejero, Tomas; Marchesi, Elena; Fogagnolo, Marco; Rafie, Karim; van Aalten, Daan M F

    2018-03-07

    A series of glycomimetics of UDP-GlcNAc in which the β-phosphate has been replaced by either an alkyl chain or a triazolyl ring and the sugar moiety has been replaced by a pyrrolidine ring have been synthesized by using different click-chemistry procedures. Their affinity for human O-GlcNAc transferase (hOGT) has been evaluated and both spectroscopically and computationally studied. The binding epitopes of the best ligands have been determined in solution using saturation transfer difference (STD) NMR spectroscopy. Experimental, spectroscopic and computational results are in agreement, pointing out the essential role for binding of the β-phosphate. We have found that the loss of interactions from the -phosphate can be counterbalanced by the presence of hydrophobic groups at a pyrroline ring acting as a surrogate of the carbohydrate unit. Two of the glycomimetics prepared reach inhibition in the micromolar scale. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. 31 CFR 596.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 596.500 Section... Licenses, Authorizations and Statements of Licensing Policy § 596.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken...

  16. 31 CFR 597.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 597.500 Section... Licenses, Authorizations, and Statements of Licensing Policy § 597.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken...

  17. 31 CFR 540.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 540.500 Section... REGULATIONS Licenses, Authorizations, and Statements of Licensing Policy § 540.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions...

  18. 31 CFR 585.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 585.500 Section... Licenses, Authorizations, and Statements of Licensing Policy § 585.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken...

  19. Feedback in analog circuits

    CERN Document Server

    Ochoa, Agustin

    2016-01-01

    This book describes a consistent and direct methodology to the analysis and design of analog circuits with particular application to circuits containing feedback. The analysis and design of circuits containing feedback is generally presented by either following a series of examples where each circuit is simplified through the use of insight or experience (someone else’s), or a complete nodal-matrix analysis generating lots of algebra. Neither of these approaches leads to gaining insight into the design process easily. The author develops a systematic approach to circuit analysis, the Driving Point Impedance and Signal Flow Graphs (DPI/SFG) method that does not require a-priori insight to the circuit being considered and results in factored analysis supporting the design function. This approach enables designers to account fully for loading and the bi-directional nature of elements both in the feedback path and in the amplifier itself, properties many times assumed negligible and ignored. Feedback circuits a...

  20. Galaxy evolution in Local Group analogs. I. A GALEX study of nearby groups dominated by late-type galaxies

    Science.gov (United States)

    Marino, A.; Bianchi, L.; Rampazzo, R.; Buson, L. M.; Bettoni, D.

    2010-02-01

    Context. Understanding the astrophysical processes acting within galaxy groups and their effects on the evolution of the galaxy population is one of the crucial topics of modern cosmology, as almost 60% of galaxies in the Local Universe are found in groups. Aims: We aim at learning about galaxy evolution within nearby groups dominated by late-type galaxies, specifically by studying their ultraviolet-emitting stellar population. Methods: We imaged in the far (FUV, λ_eff = 1539 Å) and near ultraviolet (NUV, λ_eff = 2316 Å) with the Galaxy Evolution Explorer (GALEX) three nearby groups, namely LGG 93, LGG 127 and LGG 225. We obtained the UV galaxy surface photometry and, for LGG 225, the only group covered by the SDSS, the photometry in u, g, r, i, z bands. We discuss galaxy morphologies looking for interaction signatures and we analyze the spectral energy distribution of galaxies to infer their luminosity-weighted ages. The UV and optical photometry was also used to perform a luminosity-weighted kinematical and dynamical analysis of each group and to evaluate the stellar mass. Results: A few member galaxies in LGG 225 show a distorted UV morphology due to ongoing interactions. (FUV-NUV) colors suggest that spirals in LGG 93 and LGG 225 host stellar populations in their outskirts younger than that of M 31 and M 33 in the Local Group or with less extinction. The irregular interacting galaxy NGC 3447A has a significantly younger stellar population (a few Myr old) than the average of the other irregular galaxies in LGG 225 suggesting that the encounter triggered star formation. The early-type members of LGG 225, NGC 3457 and NGC 3522, have masses of the order of a few 10^9~M_⊙, comparable to the Local Group ellipticals. For the most massive spiral in LGG 225, we estimate a stellar mass of ≈4 × 1010~M_⊙, comparable to M 33 in the Local Group. Ages of stellar populations range from a few to ≈7 Gyr for the galaxies in LGG 225. The kinematical and dynamical

  1. Beginning analog electronics through projects

    CERN Document Server

    Singmin, Andrew

    2001-01-01

    Analog electronics is the simplest way to start a fun, informative, learning program. Beginning Analog Electronics Through Projects, Second Edition was written with the needs of beginning hobbyists and students in mind. This revision of Andrew Singmin's popular Beginning Electronics Through Projects provides practical exercises, building techniques, and ideas for useful electronics projects. Additionally, it features new material on analog and digital electronics, and new projects for troubleshooting test equipment.Published in the tradition of Beginning Electronics Through Projects an

  2. Analog processor for electroluminescent detector

    International Nuclear Information System (INIS)

    Belkin, V.S.

    1988-01-01

    Analog processor for spectrometric channel of soft X-ray radiation electroluminescent detector is described. Time internal spectrometric measurer (TIM) with 1 ns/chan quick action serves as signal analyzer. Analog processor restores signals direct component, integrates detector signals and generates control pulses on the TIM input, provides signal discrimination by amplitude and duration, counts number of input pulses per measuring cycle. Flowsheet of analog processor and its man characteristics are presented. Analog processor dead time constitutes 0.5-5 ms. Signal/noise relation is ≥ 500. Scale integral nonlinearity is < 2%

  3. Part-construction licenses and preliminary licenses issued within the licensing procedure under atomic energy law

    International Nuclear Information System (INIS)

    Feldmann, F.J.

    1984-01-01

    The author elaborates a delimitation in terms of law of various licenses available under atomic energy law within the licensing procedure for nuclear installations, such as the part-construction license, preliminary license and preliminary approval of the overall concept, preliminary conceptual approval and conceptual license, preliminary conceptual approval subject to subsequent examinations and decisions, preliminary site ruling and site approval, advance permits and subsequent partial licenses. Such a delimitation becomes particularly significant in case of the plant conceptual design or the site being the subject under review, and the definitions stated also have considerable impact on administrative court proceedings. In this review the author tries to bear in mind the various interests of all parties involved in the licensing procedure. (HSCH) [de

  4. [Analogies and analogy research in technical biology and bionics].

    Science.gov (United States)

    Nachtigall, Werner

    2010-01-01

    The procedural approaches of Technical Biology and Bionics are characterized, and analogy research is identified as their common basis. The actual creative aspect in bionical research lies in recognizing and exploiting technically oriented analogies underlying a specific biological prototype to indicate a specific technical application.

  5. Children's Development of Analogical Reasoning: Insights from Scene Analogy Problems

    Science.gov (United States)

    Richland, Lindsey E.; Morrison, Robert G.; Holyoak, Keith J.

    2006-01-01

    We explored how relational complexity and featural distraction, as varied in scene analogy problems, affect children's analogical reasoning performance. Results with 3- and 4-year-olds, 6- and 7-year-olds, 9- to 11-year-olds, and 13- and 14-year-olds indicate that when children can identify the critical structural relations in a scene analogy…

  6. Effects of Multimedia and Schema Induced Analogical Reasoning on Science Learning

    Science.gov (United States)

    Zheng, R. Z.; Yang, W.; Garcia, D.; McCadden, E. P.

    2008-01-01

    The present study investigates the effects of multimedia and schema induced analogical reasoning on science learning. It involves 89 fourth grade elementary students in the north-east of the United States. Participants are randomly assigned into four conditions: (a) multimedia with analogy; (b) multimedia without analogy; (c) analogy without…

  7. HPLC and HPLC/MS/MS Studies on Stress, Accelerated and Intermediate Degradation Tests of Antivirally Active Tricyclic Analog of Acyclovir.

    Science.gov (United States)

    Lesniewska, Monika A; Dereziński, Paweł; Klupczyńska, Agnieszka; Kokot, Zenon J; Ostrowski, Tomasz; Zeidler, Joanna; Muszalska, Izabela

    2015-01-01

    The degradation behavior of a tricyclic analog of acyclovir [6-(4-MeOPh)-TACV] was determined in accordance with International Conference on Harmonization guidelines for good clinical practice under different stress conditions (neutral hydrolysis, strong acid/base degradation, oxidative decomposition, photodegradation, and thermal degradation). Accelerated [40±2°C/75%±5% relative humidity (RH)] and intermediate (30±2°C/65%±5% RH) stability tests were also performed. For observation of the degradation of the tested compound the RP-HPLC was used, whereas for the analysis of its degradation products HPLC/MS/MS was used. Degradation of the tested substance allowed its classification as unstable in neutral environment, acidic/alkaline medium, and in the presence of oxidizing agent. The tested compound was also light sensitive and was classified as photolabile both in solution and in the solid phase. However, the observed photodegradation in the solid phase was at a much lower level than in the case of photodegradation in solution. The study showed that both air temperature and RH had no significant effect on the stability of the tested substance during storage for 1 month at 100°C (dry heat) as well as during accelerated and intermediate tests. Based on the HPLC/MS/MS analysis, it can be concluded that acyclovir was formed as a degradation product of 6-(4-MeOPh)-TACV.

  8. In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations

    Directory of Open Access Journals (Sweden)

    Xiaodong Gao

    2016-05-01

    Full Text Available Checkpoint kinase 1 (Chk1 is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative structure–activity relationship (3D-QSAR modeling, molecular docking, and molecular dynamics simulations. The optimal QSAR models showed significant cross-validated correlation q2 values (0.531, 0.726, fitted correlation r2 coefficients (higher than 0.90, and standard error of prediction (less than 0.250. These results suggested that the developed models possess good predictive ability. Moreover, molecular docking and molecular dynamics simulations were applied to highlight the important interactions between the ligand and the Chk1 receptor protein. This study shows that hydrogen bonding and electrostatic forces are key interactions that confer bioactivity.

  9. Mutagenicity and antimutagenicity studies of DRDE-07 and its analogs against sulfur mustard in the in vitro Ames Salmonella/microsome assay.

    Science.gov (United States)

    Vijayan, Vinod; Pathak, Uma; Meshram, Ghansham Pundilikji

    2014-10-01

    Sulfur mustard (bis(2-chloroethyl) sulfide, SM), a chemical warfare agent, is classified as a class I human carcinogen by IARC. No effective antidote against this agent is available. The synthetic aminothiol, amifostine, earlier known as WR-2721, has been extensively used as a chemical radioprotector for normal tissues in cancer radiotherapy and chemotherapy. SM is a radiomimetic agent; this prompted us to evaluate the protective efficacy of amifostine and three of its analogs, DRDE-07 [S-2(2-aminoethylamino) ethyl phenyl sulphide], DRDE-30 [S-2(2-aminoethyl amino) ethyl propyl sulphide] and DRDE-35 [S-2(2-aminoethyl amino) ethyl butyl sulphide], against sulfur mustard-induced mutagenicity in the Ames Salmonella/microsome assay. The antidotes were also evaluated for possible mutagenic activity. DRDE-07 was mutagenic in strain TA104 in the absence of S9; DRDE-30 was mutagenic in strain TA100; amifostine and DRDE-35 did not show mutagenic activity in any of the five tester strains used. SM is mutagenic in strains TA97a and TA102, with or without S9 activation. In the antimutagenicity studies, DRDE-07 and DRDE-35 showed promising antimutagenic activity against SM in the absence of S9, in comparison to amifostine. DRDE-07 and DRDE-35 are promising protective agents against SM-induced mutagenicity. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Synthesis and Antifungal Activity against Fusarium oxysporum of Some Brassinin Analogs Derived from l-tryptophan: A DFT/B3LYP Study on the Reaction Mechanism

    Directory of Open Access Journals (Sweden)

    Diego Quiroga

    2016-10-01

    Full Text Available An efficient methodology to obtain novel antifungal analogs of brassinin 1 is described. Starting from l-tryptophan 2, N,N′-dialkylthiourea 4, 4-[(1H-indol-3-ylmethylene]-2-sulfanylidene-1,3-thiazolidin-5-one 5 and alkyl (2S-3-(1H-indol-3-yl-2-{[(alkylsulfanylcarbonothioyl]amino}propanoate 6 type compounds were obtained as main products in different ratios depending on the reaction conditions via a tandem dithiocarbamate formation and Michael addition reaction. In order to understand the dependence of the reaction conditions on the mechanism pathway, a DFT/B3LYP study was performed. The results suggested the existence of competitive mechanistic routes which involve the presence of an ionic dithiocarbamate intermediate 9. Antifungal activities of all products were then evaluated against Fusarium oxysporum through mycelial growth inhibition using a microscale amended-medium assay. IC50 values were thus determined for each compound. These results showed that 6-related compounds can be considered as promissory antifungal agents.

  11. Validation, acceptance and licensing

    International Nuclear Information System (INIS)

    Wene, C.O.

    1992-01-01

    The licensing process requires communication of complex scientific and technical information. In this paper transfer of such information is discussed using concepts and ideas from systems analysis, cybernetics and argumentation theory. A simple model for the decision process is developed. The analysis stresses the need for careful design of the communication channels between the three systems involved: the political system, the judicial-regulatory system and the scientific-technical community. The Dialogue - Scenario project initiated by the Swedish nuclear Inspectorate is briefly presented

  12. Licensed operating reactors

    International Nuclear Information System (INIS)

    1990-04-01

    The Operating Units Status Report --- Licensed Operating Reactors provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management from the Headquarters staff on NRC's Office of Enforcement (OE), from NRC's Regional Offices, and from utilities. The three sections of the report are: monthly highlights and statistics for commercial operating units, and errata from previously reported data; a compilation of detailed information on each unit, provided by NRC's Regional Offices, OE Headquarters and the utilities; and an appendix for miscellaneous information such as spent fuel storage capability, reactor-years of experience and non- power reactors in the US

  13. Licensed operating reactors

    International Nuclear Information System (INIS)

    1989-11-01

    The US Nuclear Regulatory Commission's monthly Licensed Operating Reactors Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. Since all of the data concerning operation of the units is provided by the utility operators less than two weeks after the end of the month, necessary corrections to published information are shown on the errata page

  14. Electronic devices for analog signal processing

    CERN Document Server

    Rybin, Yu K

    2012-01-01

    Electronic Devices for Analog Signal Processing is intended for engineers and post graduates and considers electronic devices applied to process analog signals in instrument making, automation, measurements, and other branches of technology. They perform various transformations of electrical signals: scaling, integration, logarithming, etc. The need in their deeper study is caused, on the one hand, by the extension of the forms of the input signal and increasing accuracy and performance of such devices, and on the other hand, new devices constantly emerge and are already widely used in practice, but no information about them are written in books on electronics. The basic approach of presenting the material in Electronic Devices for Analog Signal Processing can be formulated as follows: the study with help from self-education. While divided into seven chapters, each chapter contains theoretical material, examples of practical problems, questions and tests. The most difficult questions are marked by a diamon...

  15. NaturAnalogs for the Unsaturated Zone

    Energy Technology Data Exchange (ETDEWEB)

    A. Simmons; A. Unger; M. Murrell

    2000-03-08

    The purpose of this Analysis/Model Report (AMR) is to document natural and anthropogenic (human-induced) analog sites and processes that are applicable to flow and transport processes expected to occur at the potential Yucca Mountain repository in order to build increased confidence in modeling processes of Unsaturated Zone (UZ) flow and transport. This AMR was prepared in accordance with ''AMR Development Plan for U0135, Natural Analogs for the UZ'' (CRWMS 1999a). Knowledge from analog sites and processes is used as corroborating information to test and build confidence in flow and transport models of Yucca Mountain, Nevada. This AMR supports the Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR) and the Yucca Mountain Site Description. The objectives of this AMR are to test and build confidence in the representation of UZ processes in numerical models utilized in the UZ Flow and Transport Model. This is accomplished by: (1) applying data from Boxy Canyon, Idaho in simulations of UZ flow using the same methodologies incorporated in the Yucca Mountain UZ Flow and Transport Model to assess the fracture-matrix interaction conceptual model; (2) Providing a preliminary basis for analysis of radionuclide transport at Pena Blanca, Mexico as an analog of radionuclide transport at Yucca Mountain; and (3) Synthesizing existing information from natural analog studies to provide corroborating evidence for representation of ambient and thermally coupled UZ flow and transport processes in the UZ Model.

  16. Technology Licensing and Firm Innovation

    DEFF Research Database (Denmark)

    Moreira, Solon

    that facilitate or constrain firms' ability to deal with licensed-in technologies have received little attention. This paper starts investigating in a longitudinal setting the effect of technology licensing on the number of patents produced by the licensee within the three years subsequent to the technology...... acquisition. The findings indicate that technology licensing is positively related to the number of inventions produced by the licensee in the years subsequent to the licensing deal. Subsequently, I investigate the moderating effect that organizational slack and myopia have on this main relationship....... The findings also suggest that high levels of Organizational Slack (available financial resources) strengthen the positive effect of licensing on innovation. However, higher levels of Organizational Myopia (the extent to which a firm draws on its own knowledge) can decrease the main effect of licensing....

  17. Technology Licensing and Firm Innovation

    DEFF Research Database (Denmark)

    Moreira, Solon

    acquisition. The findings indicate that technology licensing is positively related to the number of inventions produced by the licensee in the years subsequent to the licensing deal. Subsequently, I investigate the moderating effect that organizational slack and myopia have on this main relationship...... that facilitate or constrain firms' ability to deal with licensed-in technologies have received little attention. This paper starts investigating in a longitudinal setting the effect of technology licensing on the number of patents produced by the licensee within the three years subsequent to the technology....... The findings also suggest that high levels of Organizational Slack (available financial resources) strengthen the positive effect of licensing on innovation. However, higher levels of Organizational Myopia (the extent to which a firm draws on its own knowledge) can decrease the main effect of licensing....

  18. The use of vitamin D analogs is independently associated with the favorable renal prognosis in chronic kidney disease stages 4-5: the CKD-ROUTE study.

    Science.gov (United States)

    Arai, Yohei; Kanda, Eiichiro; Iimori, Soichiro; Naito, Shotaro; Noda, Yumi; Kawasaki, Tomoki; Sato, Hidehiko; Ando, Ryoichi; Sasaki, Sei; Sohara, Eisei; Okado, Tomokazu; Rai, Tatemitsu; Uchida, Shinichi

    2017-06-01

    Vitamin D analogs have generally been recommended for treatment of mineral bone disease in chronic kidney disease (CKD). However, the association between this treatment and CKD progression has not yet been established. We designed a post hoc propensity score-matched cohort analysis derived from 3-year follow-up data of a prospective cohort. Adult participants with pre-dialysis CKD stages 4-5 who had newly been prescribed active vitamin D analogs during the observation period were eligible as matched cases. Then, matched controls were extracted from participants who had never been prescribed active vitamin D analogs. The primary outcome was a composite of end-stage renal disease or a 50 % reduction in estimated glomerular filtration rate (eGFR). A Cox proportional hazards model evaluated the association between the use of vitamin D analogs and the primary outcome. We enrolled 240 patients (males, 65 %). The number of matched cases and controls was 30 and 210, respectively. The primary outcome was observed in 94 patients, whereas 25 patients died. The mean ± standard deviation age and eGFR were 69 ± 12 years and 17 ± 5.7 ml/min/1.73 m 2 , respectively. In a Cox proportional hazard model, the use of vitamin D analogs was independently associated with a lower risk of the primary outcome (crude hazard ratio 0.41; 95 % confidence interval 0.19, 0.89; adjusted hazard ratio 0.38; 95 % confidence interval 0.17, 0.88). The use of vitamin D analogs is independently associated with the preservation of renal function in patients with pre-dialysis CKD stages 4-5.

  19. The future of vitamin D analogs

    Directory of Open Access Journals (Sweden)

    Carlien eLeyssens

    2014-04-01

    Full Text Available The active form of vitamin D3, 1,25-dihydroxyvitamin D3, is a major regulator of bone and calcium homeostasis. In addition, this hormone also inhibits the proliferation and stimulates the differentiation of normal as well as malignant cells. Supraphysiological doses of 1,25-dihydroxyvitamin D3 are required to reduce cancer cell proliferation. However, these doses will lead in vivo to calcemic side effects such as hypercalcemia and hypercalciuria. During the last 25 years, many structural analogs of 1,25-dihydroxyvitamin D3 have been synthesized by the introduction of chemical modifications in the A-ring, central CD-ring region or side chain of 1,25-dihydroxyvitamin D3 in the hope to find molecules with a clear dissociation between the beneficial antiproliferative effects and adverse calcemic side effects. One example of such an analog with a good dissociation ratio is calcipotriol (DaivonexR, which is clinically used to treat the hyperproliferative skin disease psoriasis. Other vitamin D analogs were clinically approved for the treatment of osteoporosis or secondary hyperparathyroidism. No vitamin D analog is currently used in the clinic for the treatment of cancer although several analogs have been shown to be potent drugs in animal models of cancer. Omics studies as well as in vitro cell biological experiments unraveled basic mechanisms involved in the antineoplastic effects of vitamin D and its analogs. 1,25-dihydroxyvitamin D3 and analogs act in a cell type- and tissue-specific manner. Moreover, a blockade in the transition of the G0/1 towards S phase of the cell cycle, induction of apoptosis, inhibition of migration and invasion of tumor cells together with effects on angiogenesis and inflammation have been implicated in the pleiotropic effects of 1,25-dihydroxyvitamin D3 and its analogs. In this review we will give an overview of the action of vitamin D analogs in tumor cells and look forward how these compounds could be introduced in the

  20. Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluation

    International Nuclear Information System (INIS)

    Koumarianou, Eftychia; Mikolajczak, Renata; Pawlak, Dariusz; Zikos, Xhristos; Bouziotis, Pinelopi; Garnuszek, Piotr; Karczmarczyk, Urszula; Maurin, Michal; Archimandritis, Spyridon C.

    2009-01-01

    Introduction: The aim of the study was to compare in vitro and in vivo a novel DOTA-chelated bombesin (BN) analog of the amino acid sequence, QRLGNQWAVGHLM-CONH 2 (BN[2-14]NH 2 ), labeled with 90 Y and 177 Lu, for its potential use in targeted radiotherapy of tumors expressing gastrin releasing peptide (GRP) receptors. The same amino acid sequence, but with different chelator, referred as BN1.1 (Gly-Gly-Cys-Aca-QRLGNQWAVGHLM-CONH 2 ), has already been studied and reported; however, the DOTA-chelated one, suitable for labeling with M +3 type radiometals, was not yet described. Methods: The conditions for labeling of DOTA-BN[2-14]NH 2 with noncarrier added 90 Y and with 177 Lu [specific activity (SA), 15 Ci/mg Lu] were investigated and optimized to provide 90 Y-DOTA-BN[2-14]NH 2 and 177 Lu-DOTA-BN[2-14]NH 2 of high SA. The stability of the radiolabeled compounds in human serum was evaluated over a period of 24 h. The human prostate cancer cell line PC-3, known to express GRP receptors, was used for in vitro evaluation of radiolabeled peptide affinity to GRP receptors and for assessment of cytotoxicity of both nonlabeled and radiolabeled peptide. Biodistribution accompanied by receptor blocking was studied in normal Swiss mice. Results: 90 Y-DOTA-BN[2-14]NH 2 and 177 Lu-DOTA-BN[2-14]NH 2 were obtained with radiochemical yield >98% and high SA (67.3 GBq 90 Y/μmol and 33.6 GBq 177 Lu/μmol, respectively). They were stable when incubated in human serum for up to 24 h. The binding affinities of DOTA-BN[2-14]NH 2 and both nat Y- and nat Lu-labeled analogs to GRP receptors were high (IC 50 =1.78, 1.99, and 1.34 nM, respectively), especially for the nat Lu-DOTA-BN[2-14]NH 2 complex. The cytotoxicity study of DOTA-BN[2-14]NH 2 to PC-3 cells revealed an IC 50 =6300 nM after 72 h of exposition, while the labeled derivatives showed no significant cytotoxic effect. The internalization rate to PC-3 cells was more rapid for 177 Lu-labeled peptide (84.87%) than for the 90 Y

  1. A Study on the regulation improvement through the analysis of domestic and international categorization and licensing process for large particle accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Gwon, Da-Yeong; Jeon, Yeo-Ryeong; Kim, Yong-Min [Catholic University of Daegu, Gyeongsan (Korea, Republic of); Jung, Nam-Suk; Lee, Hee-Seock [POSTECH, Pohang (Korea, Republic of)

    2016-10-15

    Many foreign countries use separate criteria and regulation procedure according to the categorization of accelerators. In Korea, nuclear and radiation related facilities are divided into 4 groups: 1) Nuclear Reactor and related facilities, 2) Nuclear fuel cycle, nuclear material facilities, 3) Disposal and transport, 4) Radioisotope and radiation generating devices related facilities. All accelerator facilities are categorized as group 4 regardless of their size and type. For facilities that belong to group 1 and 2, Radiation Environmental Impact Assessment Report(REIR) and Preliminary Decommissioning Plan Report(PDPR) should be submitted in construction licensing stage, but there are no rules about above documents for large particle accelerator facilities. Facilities that belong to 4) RI and RG, only two documents of Radiation Safety Report(RSR) and Safety Control Regulation(SCR) are submitted in licensing stage. Because there is no detailed guidelines according to facilities type, properties of each facility are not considered in preparation and licensing process. If we set up the categorization of accelerator facilities, we can expect the effective and safe construction and operation of the large accelerator facilities on the licensing and operation process. Similarly to other counties' criteria, 50 MeV of particle energy could be used as energy band of large particle accelerator. According to categorization, it is necessary to adopt graded licensing stages and separated safety documents. In case of large particle accelerators, it is appropriate to divide the licensing stages to construction and operation. We currently submit PDPR in case of reactor and related facilities, nuclear fuel cycle, and nuclear material facilities. Depending on the energy of particle accelerators, it is necessary to prepare the decontamination and decommissioning for the decrease of current and future burden from radioactive waste. From the arrangement of separated guidelines on

  2. Drawing Analogies in Environmental Education

    Science.gov (United States)

    Affifi, Ramsey

    2014-01-01

    Reconsidering the origin, process, and outcomes of analogy-making suggests practices for environmental educators who strive to disengage humans from the isolating illusions of dichotomizing frameworks. We can view analogies as outcomes of developmental processes within which human subjectivity is but an element, threading our sense of self back…

  3. Musik som analogi og metafor

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2014-01-01

    Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser......Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser...

  4. Legal foundations of adaptive licensing.

    Science.gov (United States)

    Oye, K; Baird, L G; Chia, A; Hocking, S; Hutt, P B; Lee, D; Norwalk, L; Salvatore, V

    2013-09-01

    In April 2012, MIT's Center for Biomedical Innovation and the European Medicines Agency (EMA) cosponsored a workshop on legal foundations of adaptive pharmaceuticals licensing. Past and present attorneys from the US Food and Drug Administration (FDA), the EMA, and Health Sciences Agency Singapore (HSA) found that existing statutes provided authority for adaptive licensing (AL). By contrast, an attorney from Health Canada identified gaps in authority. Reimbursement during initial phases of adaptive approaches to licensing was deemed consistent with existing statutes in all jurisdictions.

  5. The analogic model ''RIC'' of thermal behaviour of mass concrete

    International Nuclear Information System (INIS)

    Gonzalez Redondo, M.; Gonzalez de Posada, F.; Plana Claver, J.

    1997-01-01

    In order to study the thermal field and calorific flows in heat sources (i.e. mass concrete during setting) we have conceived, built and experimented with an analogical electric model. This model, named RIC, consists of resistors (R) and capacitors (C) in which nodes an electric current (I) has been injected. Several analogical constants were used for the mathematical approximation. Thus, this paper describes the analogical RIC model, simulating heat generation, boundary and initial conditions and concreting. (Author) 4 refs

  6. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    1983-01-01

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

  7. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    1982-05-01

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

  8. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    1982-08-01

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

  9. Brand Licensing Processes and Workflows

    OpenAIRE

    Törmä, Kalle

    2017-01-01

    The purpose of this Bachelor’s thesis project is to provide an end-to-end brand licensing workflow mapping and give the reader understanding of the brand licensing workflows and how they are connected in the overall process. Brand licensing business is not too familiar in Finland and could offer an opportunity for a new income stream for many companies. To manage the brand licensing program, the company needs to understand the processes associated in the business model. The goal is to res...

  10. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    1983-03-01

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

  11. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    1982-11-01

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

  12. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    1982-07-01

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

  13. Post licensing case study of community effects at two operating nuclear power plants. Final report, March 1975--March 1976

    International Nuclear Information System (INIS)

    Purdy, B.J.; Peelle, E.; Bjornstad, D.J.; Mattingly, T.J. Jr.; Soderstrom, J.; DeVault, R.C.

    1976-06-01

    The social, economic, and political/institutional impacts of two operating nuclear power complexes on two New England communities are studied. The report includes discussions of the study design and objectives, profiles of the towns of Plymouth, Massachusetts, and Waterford, Connecticut, and analysis of the social, economic, and political impacts as observed by members of the ORNL staff. Results are presented from an attitude survey as well as a social impact classification schema devised as a methodological tool

  14. Changes in analogical reasoning in adulthood.

    Science.gov (United States)

    Clark, E; Gardner, M K; Brown, G; Howell, R J

    1990-01-01

    This study sought to investigate adult intellectual development through an analysis of a particular type of cognitive ability, verbal analogical reasoning. The performance of 60 individuals between the ages of 20 and 79 was compared on 100 verbal analogies. The subjects consisted of six groups of ten individuals each (five males and five females), matched as a group for education and gender. Solution times and error rates served as the dependent measures. Results showed that there was a significant trend for the older subjects (60- and 70-year-olds) to be slower than the young subjects (20-, 30-, 40-, and 50-year-olds), but not necessarily more error prone. These data suggest that verbal analogical reasoning changes with age. Supplemental data demonstrated a change in other abilities as well (i.e., decline in perceptual-motor speed and spatial skill).

  15. Novel Gemini vitamin D3 analogs

    DEFF Research Database (Denmark)

    Okamoto, Ryoko; Gery, Sigal; Kuwayama, Yoshio

    2014-01-01

    We have synthesized 39 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] analogs having two side chains attached to carbon-20 (Gemini) with various modifications and compared their anticancer activities. Five structure-function rules emerged to identify analogs with enhanced anticancer activity. One...... of these active analogs, BXL-01-0126, was more potent than 1,25(OH)2D3 in mediating 50% clonal inhibition of cancer cell growth. Murine studies found that BXL-01-0126 and 1,25(OH)2D3 had nearly the same potency to raise serum calcium levels. Taken together, BXL-01-0126 when compared to 1,25(OH)2D3 has greater...

  16. Local licensers and recovering in VP ellipsis

    Directory of Open Access Journals (Sweden)

    Sonia Cyrino

    2005-12-01

    Full Text Available The core properties of VP ellipsis in English and Portuguese may be captured assuming that the elliptical constituent is licensed under local c-command by a verbal element in a sentence functional head. However, the lack of VP ellipsis in most Romance languages and in German, despite the existence of verb movement to sentence functional projections in these languages, suggests that a parameter is involved. Empirical evidence indicates that this parametric variation should not be attributed to a specific functional head because the functional head occupied by the verbal licenser may vary across languages and language varieties. So we will claim that the existence vs. absence of VP ellipsis in the languages considered in this study is due to the features of the functional head that intervenes between the verbal licenser and the elliptical vP phase.

  17. Analogical reasoning abilities of recovering alcoholics.

    Science.gov (United States)

    Gardner, M K; Clark, E; Bowman, M A; Miller, P J

    1989-08-01

    This study investigated analogical reasoning abilities of alcoholics who had been abstinent from alcohol for at least 1 year. Their performance was compared to that of nonalcoholic controls matched as a group for education, age, and gender. Solution times and error rates were modeled using a regression model. Results showed a nonsignificant trend for alcoholics to be faster, but more error prone, than controls. The same componential model applied to both groups, and fit them equally well. Although differences have been found in analogical reasoning ability between controls and alcoholics immediately following detoxification, we find no evidence of differences after extended periods of sobriety.

  18. Effect of a combined continuous and intermittent transcutaneous electrical nerve stimulation on pain perception of burn patients evaluated by visual analog scale: a pilot study

    Directory of Open Access Journals (Sweden)

    Pérez-Ruvalcaba I

    2015-12-01

    Full Text Available Irma Pérez-Ruvalcaba,1 Viridiana Sánchez-Hernández,1 Arieh R Mercado-Sesma2,3 1Burn Unit, Hospital de Especialidades, Centro Médico Nacional de Occidente, Mexican Institute of Social Security, 2Health Sciences Department, Centro Universitario de Tonalá, University of Guadalajara, Guadalajara, Mexico; 3Diabetes sin Complicaciones, Zapopan, Mexico Aim: The aim of this study was to assess the effect of continuous and intermittent electrical transcutaneous nerve stimulation on the perception of pain in patients with burns of different types. Materials and methods: A pilot study was conducted in 14 patients (age 30.9±7.5 years with second- and third-degree burns of different types. The burn types included electrical, fire/flame, and chemical. All patients received continuous and intermittent electrical transcutaneous nerve stimulation sessions three times per week for 4 weeks. Each session had a duration of 30 minutes. A pair of electrodes were placed around the burn. The primary efficacy endpoint was the perception of pain assessed by a visual analog scale at baseline and at the 30th day. Results: A significant reduction of pain perception was reported (8.0±1.7 vs 1.0±0.5; P=0.027 by all patients after electrical stimulation therapy. There were no reports of adverse events during the intervention period. Conclusion: Electrical stimulation could be a potential nonpharmacological therapeutic option for pain management in burn patients. Keywords: TENS, burn pain, pain management, electrotherapy

  19. The Public Opinion participation in the Nuclear Facilities Licensing Regime: A study for The Egyptian Nuclear Law and other countries laws

    International Nuclear Information System (INIS)

    Ali, A. M.; Abd El-Moniem, A. E.

    2012-12-01

    This paper deals with the Nuclear Facilities Licensing Regime and the public Opinion participation. It discusses the general conceptual framework such as the importance of public opinion in the licensing process for nuclear facilities. It deals with the transparency principle and the nuclear safety. It also an analysis the Egyptian nuclear law for regulating the nuclear and radiological activities(law No.7) and its provisions that regulate the participation of the public in the licensing process (Article No.12 paragraph No.7 and 16 ) that staled that the regulatory body will set the regulation to involve the public in the licensing and it will also issues publicly a garrulity report about the nuclear safety situation in the state. It also deals with the legal rules for licensing and the participation of public in it many states such as Japan, France and Germany. The paper concluded that the lunch of a nuclear programme should lunch, in parallel, a programme for the public communications because in the absent of such a public programme, the political decisions of nuclear programme might be lose its effectiveness and the programme might be slow dow. (Author)

  20. Study of proton radiation effects on analog IC designed for high energy physics in a BICMOS-JFET Radhard SOI technology

    Energy Technology Data Exchange (ETDEWEB)

    Dentan, M.; Delagnes, E.; Fourches, N.; Rouger, M. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee; Truche, R.; Delevoye, E.; Pontcharra, J. de; Blanc, J.P. [CEA Centre d`Etudes de Grenoble, 38 (France). Lab. d`Electronique et d`Instrumentation; Flament, O.; Leray, J.L.; Musseau, O. [CEA Centre d`Etudes de Bruyeres-le-Chatel, 91 (France); Blanquart, L.; Habrard, M.C.; Clemens, J.C.; Delpierre, P.; Mouthuy, T.

    1994-12-31

    We present results from a fast charge amplifier and a wideband analog buffer fabricated in a BiCMOS-JFET Radhard SOI technology and irradiated up to 4.5 10{sup 14} protons/cm{sup 2}. Simulations using main parameters from irradiated components fit roughly these results. (authors). 6 refs., 6 figs.

  1. Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats

    Czech Academy of Sciences Publication Activity Database

    Jíchová, Š.; Kopkan, L.; Husková, Z.; Doleželová, Š.; Neckář, Jan; Kujal, P.; Vernerová, Z.; Kramer, H. J.; Sadowski, J.; Kompanowska; Jezierska, E.; Reddy, N. R.; Falck, J. R.; Imig, J. D.; Červenka, L.

    2016-01-01

    Roč. 34, č. 10 (2016), s. 2008-2025 ISSN 0263-6352 R&D Projects: GA ČR(CZ) GA15-07544S Institutional support: RVO:67985823 Keywords : epoxyeicosatrienoic acid analog * malignant hypertension * renal blood flow autoregulation * renin-angiotensin system * sodium excretion Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 4.085, year: 2016

  2. A study on the satisfaction of medical licensing examination and the present condition of skill test in medical schools

    Directory of Open Access Journals (Sweden)

    Jang Hee Park

    2004-01-01

    Full Text Available lt has been an issue whether the current medical examination system can evaluate medical students' competencies efficiently. This study was performed to survey on the satisfaction for the current medical examination system and present situation for clinical skill test in medical schools. We conducted a survey for this research and the subjects of this study were deans, medical professors, resident and medical students. We met with interesting results. First, most respondents answered the current medical examination system couldn't evaluate the medical students' competencies efficiently. Second, many residents thought preparing for paper-pencil test was not helpful for training, while experiencing clinical skill test was helpful for it. Third, the current contents and methods to evaluate clinical skill in the medical schools were variable and desirable. We concluded it was high time to change our medical examination system for evaluating the clinical skill performance of medical students.

  3. Experiments of analog states on Lead 206 and 207

    International Nuclear Information System (INIS)

    Adam, Albert

    1967-01-01

    This research thesis aims at verifying hypotheses according to which the spread of analog states decreases as much as nuclei are far from a double magic nucleus, under some conditions. Therefore, analog states of lead 207 and 208 have been studied by proton scattering on targets in lead 206 and 207. Some theoretical aspects of analog states of isobaric spin are presented. An experimental method of determination of excitation functions is described. Results obtained for analog states in bismuth 207-208 are discussed. Results obtained on four steady lead isotopes in different laboratories are compared [fr

  4. Children's analogical reasoning in a third-grade science discussion

    Science.gov (United States)

    May, David B.; Hammer, David; Roy, Patricia

    2006-03-01

    Expert scientific inquiry involves the generation and use of analogies. How and when students might develop this aspect of expertise has implications for understanding how and when instruction might facilitate that development. In a study of K-8 student inquiry in physical science, we are examining cases of spontaneous analogy generation. In the case we present here, a third-grader generates an analogy and modifies it to reconcile his classmates' counterarguments, allowing us to identify in these third-graders specific aspects of nascent expertise in analogy use. Promoting abilities and inclinations such as these children display requires that educators recognize and respond to them.

  5. Measuring fatigue in rheumatoid arthritis: a cross-sectional study to evaluate the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional questionnaire, visual analog scales, and numerical rating scales.

    Science.gov (United States)

    Nicklin, Joanna; Cramp, Fiona; Kirwan, John; Greenwood, Rosemary; Urban, Marie; Hewlett, Sarah

    2010-11-01

    Current patient-reported outcome measures of fatigue in rheumatoid arthritis (RA) have limitations, providing only a global perspective. This study constructed a questionnaire (the Bristol RA Fatigue Multi-Dimensional Questionnaire [BRAF-MDQ]) from 45 preliminary questions derived from analysis of patient interviews and surveys and explored its structure for fatigue dimensions. The BRAF-MDQ and short BRAF numerical rating scales (NRS) and visual analog scales (VAS) for severity, effect, and ability to cope with fatigue were evaluated for validity. Two hundred twenty-nine RA patients with fatigue (VAS score ≥5 of 10) completed preliminary BRAF and comparator fatigue scales. Iterative analyses informed item removal or retention in the BRAF-MDQ and identification of subscales (using Cronbach's alpha for internal consistency and factor analysis to identify dimensions). The BRAF-MDQ and short scales were tested in relation to potentially associated variables for criterion and construct validity (Spearman's correlation). The 20-item BRAF-MDQ had good internal consistency (Cronbach's α = 0.932), criterion validity (correlation with other fatigue scales: r = 0.643-0.813), and construct validity (correlations with disability, mood, helplessness, and pain: r = 0.340-0.627). Factor analysis showed 4 distinct dimensions (physical fatigue, living with fatigue, cognition fatigue, and emotional fatigue), which correlated well with the RA Multidimensional Assessment of Fatigue scale (r = 0.548-0.834). The BRAF VAS and NRS showed similar criterion and construct validity. The BRAF instruments include standardized NRS and VAS for fatigue severity, effect, and coping, are RA specific, and have evidence to support validity. The BRAF-MDQ uniquely measures 4 separate dimensions, which may facilitate development of individually-tailored fatigue management programs. Copyright © 2010 by the American College of Rheumatology.

  6. Analog fourier transform channelizer and OFDM receiver

    OpenAIRE

    2007-01-01

    An OFDM receiver having an analog multiplier based I-Q channelizing filter, samples and holds consecutive analog I-Q samples of an I-Q baseband, the I-Q basebands having OFDM sub-channels. A lattice of analog I-Q multipliers and analog I-Q summers concurrently receives the held analog I-Q samples, performs analog I-Q multiplications and analog I-Q additions to concurrently generate a plurality of analog I-Q output signals, representing an N-point discrete Fourier transform of the held analog ...

  7. Licensed operating reactors

    International Nuclear Information System (INIS)

    1989-08-01

    THE OPERATING UNITS STATUS REPORT - LICENSED OPERATING REACTORS provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management from the Headquarters staff of NRC's Office of Enforcement (OE), from NRC's Regional Offices, and from utilities. The three sections of the report are: monthly highlights and statistics for commercial operating units, and errata from previously reported data; a compilation of detailed information on each unit, provided by NRC's Regional Offices, OE Headquarters and the utilities; and an appendix for miscellaneous information such as spent fuel storage capability, reactor-years of experience and non-power reactors in the US

  8. Licensed operating reactors

    International Nuclear Information System (INIS)

    1991-08-01

    The Nuclear Regulatory Commission's annual summary of licensed nuclear power reactor data is based primarily on the report of operating data submitted by licensees for each unit for the month of December because that report contains data for the month of December, the year to date (in this case calendar 1990) and cumulative data, usually from the date of commercial operation. The data is not independently verified, but various computer checks are made. The report is divided into two sections. The first contains summary highlights and the second contains data on each individual unit in commercial operation. Section 1 capacity and availability factors are simple arithmetic averages. Section 2 items in the cumulative column are generally as reported by the licensee and notes as to the use of weighted averages and starting dates other than commercial operation are provided

  9. Licensed operating reactors

    International Nuclear Information System (INIS)

    1989-08-01

    The US Nuclear Regulatory Commission's monthly LICENSED OPERATING REACTORS Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  10. Licensed operating reactors

    International Nuclear Information System (INIS)

    1990-01-01

    The US Nuclear Regulatory Commission's monthly LICENSED OPERATING REACTORS Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the Utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  11. Licensed operating reactors

    International Nuclear Information System (INIS)

    Hartfield, R.A.

    1990-03-01

    The US Nuclear Regulatory Commission's monthly Licensed Operating Reactors Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the Utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  12. Is the link from working memory to analogy causal? No analogy improvements following working memory training gains.

    Directory of Open Access Journals (Sweden)

    J Elizabeth Richey

    Full Text Available Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data, but less work has tested this relationship through experimental manipulation. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although somewhat controversial, body of literature suggests complex working memory training can sometimes lead to working memory improvements that transfer to novel working memory tasks. This study investigated whether working memory improvements, if replicated, would increase analogical reasoning ability. We assessed participants' performance on verbal and visual analogy tasks after a complex working memory training program incorporating verbal and spatial tasks. Participants' improvements on the working memory training tasks transferred to other short-term and working memory tasks, supporting the possibility of broad effects of working memory training. However, we found no effects on analogical reasoning. We propose several possible explanations for the lack of an impact of working memory improvements on analogical reasoning.

  13. Is the Link from Working Memory to Analogy Causal? No Analogy Improvements following Working Memory Training Gains

    Science.gov (United States)

    Richey, J. Elizabeth; Phillips, Jeffrey S.; Schunn, Christian D.; Schneider, Walter

    2014-01-01

    Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data [1], but less work has tested this relationship through experimental manipulation [2]. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although somewhat controversial, body of literature suggests complex working memory training can sometimes lead to working memory improvements that transfer to novel working memory tasks. This study investigated whether working memory improvements, if replicated, would increase analogical reasoning ability. We assessed participants’ performance on verbal and visual analogy tasks after a complex working memory training program incorporating verbal and spatial tasks [3], [4]. Participants’ improvements on the working memory training tasks transferred to other short-term and working memory tasks, supporting the possibility of broad effects of working memory training. However, we found no effects on analogical reasoning. We propose several possible explanations for the lack of an impact of working memory improvements on analogical reasoning. PMID:25188356

  14. Is the link from working memory to analogy causal? No analogy improvements following working memory training gains.

    Science.gov (United States)

    Richey, J Elizabeth; Phillips, Jeffrey S; Schunn, Christian D; Schneider, Walter

    2014-01-01

    Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data, but less work has tested this relationship through experimental manipulation. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although somewhat controversial, body of literature suggests complex working memory training can sometimes lead to working memory improvements that transfer to novel working memory tasks. This study investigated whether working memory improvements, if replicated, would increase analogical reasoning ability. We assessed participants' performance on verbal and visual analogy tasks after a complex working memory training program incorporating verbal and spatial tasks. Participants' improvements on the working memory training tasks transferred to other short-term and working memory tasks, supporting the possibility of broad effects of working memory training. However, we found no effects on analogical reasoning. We propose several possible explanations for the lack of an impact of working memory improvements on analogical reasoning.

  15. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel J M

    2010-01-01

    The design of an analog-to-digital converter or digital-to-analog converter is one of the most fascinating tasks in micro-electronics. In a converter the analog world with all its intricacies meets the realm of the formal digital abstraction. Both disciplines must be understood for an optimum conversion solution. In a converter also system challenges meet technology opportunities. Modern systems rely on analog-to-digital converters as an essential part of the complex chain to access the physical world. And processors need the ultimate performance of digital-to-analog converters to present the results of their complex algorithms. The same progress in CMOS technology that enables these VLSI digital systems creates new challenges for analog-to-digital converters: lower signal swings, less power and variability issues. Last but not least, the analog-to-digital converter must follow the cost reduction trend. These changing boundary conditions require micro-electronics engineers to consider their design choices for...

  16. Waste management and licensing

    International Nuclear Information System (INIS)

    Dauk, W.

    1980-01-01

    It is the Court's consideration of the repercussions the regulation on waste management of Sect. 9a of the Atomic Energy Law will have, relating to the licensing of a plant according to Sect. 7 (2) of the Atomic Energy Law which is noteworthy. Overruling its former legal conception, the Administrative Court Schleswig now assumes, together with the public opinion, that the problem of waste management being brought to a point only with the initial operation of a nuclear power station is accordingly to be taken into account in line with the discretion of licensing according to Sect. 7 (2) of the Atomic Energy Law. In addition, the Administrative Court expressed its opinion on the extent to the right of a neighbour to a nuclear power station to file suit. According to the Sections 114 and 42 (2) of the rules of Administrative Courts it is true that a plaintiff cannot take action to set aside the licence because public interests have not been taken into account sufficiently, but he may do so because his own interests have not been included in the discretionary decision. The Administrative Court is reserved when qualifying the regulation on waste management with regard to the intensity of legal control. The Court is not supposed to replace controversial issues of technology and natural sciences on the part of the executive and its experts by its own assessment. According to the proceedings, the judicial review refers to the finding as to whether decisions made by authorities are suited - according to the way in which they were made - to guarantee the safety standard prescribed in Subdivision 3 of Sect. 7 (2) of the Atomic Energy Law. (HSCH) [de

  17. Using Analogies to Prevent Misconceptions about Chemical Equilibrium

    Science.gov (United States)

    Sahin Pekmez, Esin

    2010-01-01

    The main purpose of this study was to find the effectiveness of using analogies to prevent misconceptions about chemical equilibrium. Nineteen analogies, which were based on dynamic aspects of chemical equilibrium and application of Le Chatelier's principle, were developed. The participations of this study consisted of 11th grade students (n: 151)…

  18. 7 CFR 6.33 - License fee.

    Science.gov (United States)

    2010-01-01

    .... Where the license at issue is a historical license, this will result, pursuant to § 6.23(b), in the person's loss of historical eligibility for such license. (d) Licensees may elect not to accept certain... License fee. (a) A fee will be assessed each quota year for each license to defray the Department's costs...

  19. 10 CFR 60.43 - License specification.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License specification. 60.43 Section 60.43 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES Licenses License Issuance and Amendment § 60.43 License specification. (a) A license issued under this part shall...

  20. 31 CFR 575.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 575.500 Section..., and Statements of Licensing Policy § 575.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken pursuant to part 501...

  1. 31 CFR 595.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 595.500 Section..., Authorizations, and Statements of Licensing Policy § 595.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken pursuant to part 501...

  2. 31 CFR 545.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 545.500 Section..., Authorizations and Statements of Licensing Policy § 545.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken pursuant to part 501...

  3. 31 CFR 538.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 538.500 Section..., and Statements of Licensing Policy § 538.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken pursuant to part 501...

  4. 31 CFR 501.801 - Licensing.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing. 501.801 Section 501.801... § 501.801 Licensing. (a) General licenses. General licenses have been issued authorizing under... either will be specified by the statement of licensing policy in the part under which the registration...

  5. 31 CFR 560.500 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 560.500 Section..., Authorizations and Statements of Licensing Policy § 560.500 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken pursuant to part 501...

  6. A Meta-Analytic Review of Moral Licensing

    NARCIS (Netherlands)

    Blanken, Irene; van de Ven, Niels; Zeelenberg, Marcel

    2015-01-01

    Moral licensing refers to the effect that when people initially behave in a moral way, they are later more likely to display behaviors that are immoral, unethical, or otherwise problematic. We provide a state-of-the-art overview of moral licensing by conducting a meta-analysis of 91 studies (7,397

  7. A meta-analytic review of moral licensing

    NARCIS (Netherlands)

    Blanken, I.; van de Ven, N.; Zeelenberg, M.

    2015-01-01

    Moral licensing refers to the effect that when people initially behave in a moral way, they are later more likely to display behaviors that are immoral, unethical, or otherwise problematic. We provide a state-of-the-art overview of moral licensing by conducting a meta-analysis of 91 studies (7,397

  8. Publishing and Alternative Licensing Model of Africa (PALM Africa ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant will allow PALM Africa to conduct a comparative study of the viability of publishing demonstration projects involving flexible licensing agreements in South Africa and Uganda. The team will help local publishers better understand and use alternative licensing and new business models that take advantage of the ...

  9. Welfare Effects of Entry into International Markets with Licensing

    Science.gov (United States)

    Ferreira, F. A.; Ferreira, Fl.

    2008-10-01

    We study the effects of entry of a foreign firm on domestic welfare in the presence of licensing, when the entrant is technologically inferior to the incumbent. We show that foreign entry increases domestic welfare for intermediate (respectively, sufficiently large) technological differences between the firms under licensing with fixed fee (respectively, output royalty).

  10. Effects of Test Item Disclosure on Medical Licensing Examination

    Science.gov (United States)

    Yang, Eunbae B.; Lee, Myung Ae; Park, Yoon Soo

    2018-01-01

    In 2012, the National Health Personnel Licensing Examination Board of Korea decided to publicly disclose all test items and answers to satisfy the test takers' right to know and enhance the transparency of tests administered by the government. This study investigated the effects of item disclosure on the medical licensing examination (MLE),…

  11. Responsibilities of NARM Licensing States

    International Nuclear Information System (INIS)

    Tapert, Allan C.; Bailey, Edgar D.

    1978-01-01

    There are 30 Licensing States of Naturally Occurring and Accelerator-Produced Radioactive Materials (NARM) in the U.S. In these States NARM is licensed in a similar manner as is by-product material in the Agreement States. Each Licensing State has the responsibility to identify and evaluate NARM products including informing other State and Federal radiation control agencies of potential problems encountered during the lifetime of the product. Licensing States have authority to perform on-site inspections of manufacturers, enforce radiation regulations, require compliance with all conditions of the license, and amend or terminate the license for possession and use of NARM. A Licensing State also has the responsibility to accept the recommendation on NARM products evaluated by other Licensing States. To assist States in the evaluation of NARM products the Conference of Radiation Control Program Directors developed a report entitled 'Guides for Naturally Occurring and Accelerator-Produced Radioactive Materials (NARM).' The NARM Guides report (HEW Publication (FDA) 77-8025) was published by the Bureau of Radiological Health/FDA in July 1977. The NARM Guides establish uniform criteria for evaluating the manufacture, assembly and distribution of NARM products in the U.S. The Radioactive Materials Reference Manual which is coordinated by BRH/FDA is the medium for communicating NARM information with the radiation control agencies of the 50 States, certain Federal and local agencies. (author)

  12. Gemini analogs of vitamin D.

    Science.gov (United States)

    Pazos, Gonzalo; Rivadulla, Marcos L; Pérez-García, Xenxo; Gandara, Zoila; Pérez, Manuel

    2014-01-01

    The Gemini analogs are the last significant contribution to the family of vitamin D derivatives in medicine, for the treatment of cancer. The first Gemini analog was characterized by two symmetric side chains at C-20. Following numerous modifications, the most active analog bears a C-23-triple bond, C-26, 27- hexafluoro substituents on one side chain and a terminal trideuteromethylhydroxy group on the other side chain. This progression was possible due to improvements in the synthetic methods for the preparation of these derivatives, which allowed for increasing molecular complexity and complete diastereoselective control at C-20 and the substituted sidechains.

  13. Analog Systems for Gravity Duals

    OpenAIRE

    Hossenfelder, S.

    2014-01-01

    We show that analog gravity systems exist for charged, planar black holes in asymptotic Anti-de Sitter space. These black holes have been employed to describe, via the gauge-gravity duality, strongly coupled condensed matter systems on the boundary of AdS-space. The analog gravity system is a different condensed matter system that, in a suitable limit, describes the same bulk physics as the theory on the AdS boundary. This combination of the gauge-gravity duality and analog gravity therefore ...

  14. Licensing Process for Nuclear Installations

    International Nuclear Information System (INIS)

    2011-01-01

    This Safety Guide describes how the licensing process should be applied at the various stages of the lifetime of a nuclear installation, with discussion of topics and required documents to be considered at each stage. Recommendations on the application by a regulatory body of a graded approach in the licensing process are also provided. It also describes the processes that should be undertaken to meet the regulatory and legal requirements in a Member State to authorize the establishment of a nuclear installation and/or initiation of its activities. While this Safety Guide focuses on safety at nuclear installations, it is noted that integration of safety and security aspects should be considered and evaluated by the regulatory body in the licensing process. Contents: 1. Introduction; 2. General recommendations for the licensing process; 3. Steps of the licensing process; Appendix I: Examples of documents to be submitted to the regulatory body.

  15. Altered Underlying Renal Tubular Function in Patients With Chronic Hepatitis B Receiving Nucleos(t)ide Analogs in a Real-World Setting: The MENTE Study.

    Science.gov (United States)

    Rodríguez-Nóvoa, Sonia; García-Samaniego, Javier; Prieto, Martín; Calleja, José L; Pascasio, Juan M; Delgado Blanco, Manuel; Crespo, Javier; Buti, María; Bonet Vidal, Maria L; Arenas Ruiz Tapiador, Juan; Fernández-Rodríguez, Conrado; Solá, Ricard; Fraga, Enrique; González Diéguez, Luisa; Núñez, Oscar; Praga, Manuel; Del Pino-Montes, Javier; Romero-Gómez, Manuel; Morillas, Rosa; Diago, Moisés; Castro, Ángeles

    2016-10-01

    Cases of renal tubular dysfunction have been reported in patients with hepatitis B and in patients with human immunodeficiency virus who are undergoing tenofovir treatment. However, little is known about the impact on tubular function in patients with chronic hepatitis B (CHB) under long-term use of entecavir (ETV) and tenofovir disoproxil fumarate (TDF). We evaluated markers of renal tubular function and bone turnover in patients with CHB treated with ETV or TDF. A multicenter, cross-sectional study was performed on markers of renal tubular function and bone turnover in hepatitis B virus-monoinfected patients on long-term treatment with Entecavir or Tenofovir (the MENTE study). The analyzed parameters were: retinol-binding protein/creatinine, neutrophil gelatinase-associated lipocalin/creatinine, excretion of phosphates, uric acid excretion, glomerular filtrate, protein/creatinine, albumin/creatinine, serum creatinine, phosphate, CTX, P1NP, vitamin D, and parathormone. A total of 280 patients (ETV: 89, TDF: 69, control: 122) were included in this study. The TDF group was associated with altered levels of retinol-binding protein (RBP)/creatinine (TDF 25% vs. 7% ETV and control; P<0.001). Protein/creatinine, uric acid excretion, P1NP1, and parathormone were higher in the TDF group. The proportion of patients with serum phosphate <2.5 mg/dL was higher in both the ETV and the TDF groups compared with the control. The multivariate analysis showed that the use of TDF was independently associated with a higher risk of altered excretion of RBP/creatinine (4.4; interquartile range: 1.4 to 14; P=0.013). We found an independent association between TDF use and altered RBP excretion. This finding indicates subclinical tubular damage. Because tubular dysfunction can precede the decline of renal function, close monitoring of RBP levels in patients with CHB on nucleos(t)ide analog treatment must be performed for early detection of TDF-related renal toxicity. In this study, these

  16. Analog filters in nanometer CMOS

    CERN Document Server

    Uhrmann, Heimo; Zimmermann, Horst

    2014-01-01

    Starting from the basics of analog filters and the poor transistor characteristics in nanometer CMOS 10 high-performance analog filters developed by the authors in 120 nm and 65 nm CMOS are described extensively. Among them are gm-C filters, current-mode filters, and active filters for system-on-chip realization for Bluetooth, WCDMA, UWB, DVB-H, and LTE applications. For the active filters several operational amplifier designs are described. The book, furthermore, contains a review of the newest state of research on low-voltage low-power analog filters. To cover the topic of the book comprehensively, linearization issues and measurement methods for the characterization of advanced analog filters are introduced in addition. Numerous elaborate illustrations promote an easy comprehension. This book will be of value to engineers and researchers in industry as well as scientists and Ph.D students at universities. The book is also recommendable to graduate students specializing on nanoelectronics, microelectronics ...

  17. Teenagers' licensing decisions and their views of licensing policies: a national survey.

    Science.gov (United States)

    Williams, Allan F

    2011-08-01

    One objective was to determine teenage licensing rates on a national basis, interest in early licensure, and reasons for delay. A second objective was to learn teenagers' opinions about licensing policies, important in states considering ways to upgrade their current licensing systems. One thousand three hundred eighty-three 15- to 18-year-olds completed an online survey in November 2010. They were drawn from a nationally representative panel of US households recruited using probability-based sampling. The panel included cell phone-only households, and Internet access was provided to those without it. Weighting procedures were applied so that the study population represented the national US population of 15- to 18-year-olds. Most teens said that they were interested in getting a license as soon as legally possible, but many had not started the process. At 16, teens were about equally divided among those who had not started, those in the learner stage, and those with a restricted or full license. At 18, 62 percent had full licenses; 22 percent had not started. For those old enough to start, lack of a car, costs, parent availability, ability to get around without a car, and being busy with other activities were leading reasons for delay. The majority of teens were not in favor of higher licensing ages. Forty-six percent thought the minimum learner age should be 16; 30 percent thought the full license age should be 18 or older. The majority approved of night (78%) and passenger (57%) restrictions, and 85 and 93 percent endorsed cell phone and texting bans, respectively. When these policies were packaged together in a single law that included an age 16 start, night, passenger, cell phone and texting bans, and a full license at age 18, 74 percent of teens were in favor. Teenagers are not as supportive of strong licensing policies as parents of teens, but there is evidence that they will support comprehensive policies likely to lead to further reductions in teen crash

  18. Effectiveness of Oregon's teen licensing program.

    Science.gov (United States)

    2008-06-01

    Significant changes in Oregons teen licensing laws went into effect on March 1, 2000. The new laws expanded the provisional driving license program which had been in effect since October 1989 and established a graduated driver licensing (GDL) prog...

  19. 31 CFR 596.306 - License.

    Science.gov (United States)

    2010-07-01

    ... ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.306 License. Except as otherwise specified, the term license means any license or...

  20. 31 CFR 596.305 - General license.

    Science.gov (United States)

    2010-07-01

    ... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM LIST GOVERNMENTS SANCTIONS REGULATIONS General Definitions § 596.305 General license. The term general license means any license or authorization...

  1. 47 CFR 25.212 - Narrowband analog transmissions, digital transmissions, and video transmissions in the GSO Fixed...

    Science.gov (United States)

    2010-10-01

    ... be routinely licensed for transmission of SCPC services if the maximum power densities into the antenna do not exceed +0.5 dBW/4 kHz for analog SCPC carriers with bandwidths up to 200 kHz, and do not exceed −2.7 dBW/4 kHz for narrow and/or wideband digital SCPC carriers. (2) For earth stations licensed...

  2. Use of analogies by novice and experienced design engineers

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Christensen, Bo T.

    2008-01-01

    This paper describes a study to understand the use of analogies by design engineers with different levels of experience. Protocol analyses of twelve design engineers have been analysed to understand the functions and reasoning of the analogies. The protocols are real world data from the aerospace...

  3. Introducing Analog Drawing into a Prison Art Education Setting.

    Science.gov (United States)

    Yesh, Patrick

    A qualitative research study documents the progress of an adult male art student enrolled in a grade nine art class of adult males in a federal, maximum security penitentiary. Analog drawings were used as part of the curriculum. An analog drawing is a symbolic drawing expressing one's emotions, ideas, and feelings, often used to identify and help…

  4. Young Children's Analogical Problem Solving: Gaining Insights from Video Displays

    Science.gov (United States)

    Chen, Zhe; Siegler, Robert S.

    2013-01-01

    This study examined how toddlers gain insights from source video displays and use the insights to solve analogous problems. Two- to 2.5-year-olds viewed a source video illustrating a problem-solving strategy and then attempted to solve analogous problems. Older but not younger toddlers extracted the problem-solving strategy depicted in the video…

  5. Young Children's Analogical Reasoning: The Role of Immediate Feedback

    Science.gov (United States)

    Chiu, Shuhui; Alexander, Patricia A.

    2014-01-01

    In this study, a computerized measure, Interactive Analogical Measure (IAM), was developed and used to assess young children's ability to reason analogically. The IAM was equipped to provide corrective feedback and the effects of that feedback were tested for experimental and control groups. A group of 5-year-olds (N = 80) participated in the…

  6. Analysis of Attention and Analogical Reasoning in Children of Poverty

    Science.gov (United States)

    Weatherholt, Tara N.; Harris, Ruby C.; Burns, Barbara M.; Clement, Catherine

    2006-01-01

    This study examined the relationship between specific attentional aspects of processing capacity and analogical reasoning in children from low-income families. 77 children aged 48-77 (M = 56.7) months were assessed on an analogical reasoning task (matrices subtest of the Kaufman Brief Intelligence Test) and on computerized attention tasks designed…

  7. Osilodrostat (LCI699), a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats

    Energy Technology Data Exchange (ETDEWEB)

    Li, Li, E-mail: li1.li@novartis.com [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Vashisht, Kapil; Boisclair, Julie [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Li, Wenkui; Lin, Tsu-han [Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Schmid, Herbert A. [Novartis Oncology Development, Basel (Switzerland); Kluwe, William; Schoenfeld, Heidi; Hoffmann, Peter [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States)

    2015-08-01

    The somatostatin analog pasireotide and the 11β-hydroxylase inhibitor osilodrostat (LCI699) reduce cortisol levels by distinct mechanisms of action. There exists a scientific rationale to investigate the clinical efficacy of these two agents in combination. This manuscript reports the results of a toxicology study in rats, evaluating different doses of osilodrostat and pasireotide alone and in combination. Sixty male and 60 female rats were randomized into single-sex groups to receive daily doses of pasireotide (0.3 mg/kg/day, subcutaneously), osilodrostat (20 mg/kg/day, orally), osilodrostat/pasireotide in combination (low dose, 1.5/0.03 mg/kg/day; mid-dose, 5/0.1 mg/kg/day; or high dose, 20/0.3 mg/kg/day), or vehicle for 13 weeks. Mean body-weight gains from baseline to Week 13 were significantly lower in the pasireotide-alone and combined-treatment groups compared to controls, and were significantly higher in female rats receiving osilodrostat monotherapy. Osilodrostat and pasireotide monotherapies were associated with significant changes in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat alone was associated with adrenocortical hypertrophy and hepatocellular hypertrophy. In combination, osilodrostat/pasireotide did not exacerbate any target organ changes and ameliorated the liver and adrenal gland changes observed with monotherapy. C{sub max} and AUC{sub 0–24h} of osilodrostat and pasireotide increased in an approximately dose-proportional manner. In conclusion, the pasireotide and osilodrostat combination did not exacerbate changes in target organ weight or toxicity compared with either monotherapy, and had an acceptable safety profile; addition of pasireotide to the osilodrostat regimen may attenuate potential adrenal gland hyperactivation and hepatocellular hypertrophy, which are potential side effects of osilodrostat monotherapy. - Highlights: • We examined the target organ toxicity of SOM230

  8. Licensed operating reactors

    International Nuclear Information System (INIS)

    1989-06-01

    The US Nuclear Regulatory Commission's monthly LICENSED OPERATING REACTORS Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. Since all of the data concerning operation of the units are provided by the utility operators less than two weeks after the end of the month, necessary corrections to published information are shown on the ERRATA page. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the Utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  9. Graduated Driver Licensing

    Science.gov (United States)

    Bates, Lyndel J.; Allen, Siobhan; Armstrong, Kerry; Watson, Barry; King, Mark J.; Davey, Jeremy

    2014-01-01

    Graduated driver licensing (GDL) aims to gradually increase the exposure of new drivers to more complex driving situations and typically consists of learner, provisional and open licence phases. The first phase, the learner licence, is designed to allow novice drivers to obtain practical driving experience in lower risk situations. The learner licence can delay licensure, encourage novice drivers to learn under supervision, mandate the number of hours of practice required to progress to the next phase and encourage parental involvement. The second phase, the provisional licence, establishes various driving restrictions and thereby reduces exposure to situations of higher risk, such as driving at night, with passengers or after drinking alcohol. Parental involvement with a GDL system appears essential in helping novices obtain sufficient practice and in enforcing compliance with restrictions once the new driver obtains a provisional licence. Given the significant number of young drivers involved in crashes within Oman, GDL is one countermeasure that may be beneficial in reducing crash risk and involvement for this group. PMID:25364543

  10. VEHICLES LICENSED IN SWITZERLAND

    CERN Multimedia

    Service des Relations avec les Pays-Hôtes

    2000-01-01

    1.\tVehicle licensinga)\tTime limitsVehicles must have a Swiss registration document and Swiss number plates: -\tif the owner has been residing in Switzerland for more than one year without a break of more than three consecutive months and has been using it for more than one month on Swiss territory, or -\tif the vehicle itself has been on Swiss territory for more than one year without a break of more than three consecutive months. b)\tTechnical details Vehicles belonging to non-Swiss members of the personnel who hold a carte de légitimation issued by the Swiss Federal Department of Foreign Affairs (hereinafter referred to as 'DFAE') and who were not permanently resident in Switzerland before taking up their appointment may be licensed in Switzerland with virtually no restrictions provided that their owner produces: -\tthe vehicle registration document and number plates of the country in which the car was previously registered, or -\ta manufacturer's certi...

  11. Licensing criteria for nuclear medicine

    International Nuclear Information System (INIS)

    Westerman, B.R.

    1986-01-01

    The use of radioactive materials in medicine is one of the most highly regulated areas the physician has to deal with. There are three basic types of licenses for use of radioactive material defined in the Code of Federal Regulations (CFR), chapter 10, part 35. These are the general license, which is mainly applicable to small volume in vitro work; the specific license, which is used in most medical facilities; and the broad license, which is suited for larger research-oriented practices. Licensing requires proof of competence of the user and of adequate provision for protection of public health. Materials used in medicine are grouped for convenience into three diagnostic categories and two therapeutic categories. A sixth group, for sealed implants, is not generally applicable in nuclear medicine. Training and experience of users may be documented in a number of ways, including board certification in nuclear medicine. Therapeutic applications require additional proof of direct personal experience. The radiation safety officer is a pivotal individual in the licensing procedure, being directly responsible for carrying out the highly detailed requirements for protection of personnel and patients. A radiation safety program based on the as low as reasonably achievable (ALARA) concept requires personal monitoring, inventory control, detection and control of contamination, and strict adherence to licensing rules. Training of personnel and proper maintenance of equipment and facilities are also vital parts of the licensing process. The requirements of licensing and for renewal are clearly spelled out by the various regulatory agencies and require meticulous record keeping with documentation that all prescribed procedures have been followed and duly recorded

  12. Licensing Trends for Construction of New Nuclear Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Bae-Hyeuk; Ahn, Kyu-Suk; Kim, Young-Gyun; Kim, Tae-Wan; Baek, Jong-Hyuk [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    Currently in Korea, an SFR (Sodium-cooled Fast Reactor) technology proving stage reactor called PGSFR (Prototype Gen-IV SFR) is being developed by KAERI and KEPCO E and C to be constructed by 2028. After the accident of the Fukushima nuclear power plants, how to regulate and license newly developing nuclear reactors requiring higher safety goals has been issued. As a result, in leading nuclear nations developing new reactors, the close cooperation between the developer and the regulator is becoming very important. In this study, the licensing processes of leading nuclear countries were surveyed and compared with that of Korea, and a new licensing direction for PGSFR was suggested. Reviewing licensing processes for newly developing reactors of other countries, the first step of the licensing process is the pre-safety review, which is to review the reactor design. This process is not legally binding, but is a review process for a better understanding of newly applied technologies by regulators prior to starting the legally binding licensing process as the construction and operation licensing. This process provides an opportunity for the reactor developer to adopt the regulator's licensing direction and a goal to designing newly developing reactors to meet the safety requirements.

  13. Analog approach to mixed analog-digital circuit simulation

    Science.gov (United States)

    Ogrodzki, Jan

    2013-10-01

    Logic simulation of digital circuits is a well explored research area. Most up-to-date CAD tools for digital circuits simulation use an event driven, selective trace algorithm and Hardware Description Languages (HDL), e.g. the VHDL. This techniques enable simulation of mixed circuits, as well, where an analog part is connected to the digital one through D/A and A/D converters. The event-driven mixed simulation applies a unified, digital-circuits dedicated method to both digital and analog subsystems. In recent years HDL techniques have been also applied to mixed domains, as e.g. in the VHDL-AMS. This paper presents an approach dual to the event-driven one, where an analog part together with a digital one and with converters is treated as the analog subsystem and is simulated by means of circuit simulation techniques. In our problem an analog solver used yields some numerical problems caused by nonlinearities of digital elements. Efficient methods for overriding these difficulties have been proposed.

  14. Regulatory guidance for license renewal

    International Nuclear Information System (INIS)

    Thoma, John A.

    1991-01-01

    The proposed 10 CFR Part 54 rule proceduralizes the process for license renewal by identifying both the administrative and technical requirements for a renewal application. To amplify and support this regulation, written guidance has been provided in the form of a draft Regulatory Guide (DG 1009) and a draft Standard Review Plan for License Renewal (NUREG 1299). This guidance is scheduled to be finalized in 1992. Similar guidance will be provided for the proposed revisions to 10 CFR Part 51 concerning the environmental aspects of license renewal. (author)

  15. Applying analog integrated circuits for HERO protection

    Science.gov (United States)

    Willis, Kenneth E.; Blachowski, Thomas J.

    1994-01-01

    One of the most efficient methods for protecting electro-explosive devices (EED's) from HERO and ESD is to shield the EED in a conducting shell (Faraday cage). Electrical energy is transferred to the bridge by means of a magnetic coupling which passes through a portion of the conducting shell that is made from a magnetically permeable but electrically conducting material. This technique was perfected by ML Aviation, a U.K. company, in the early 80's, and was called a Radio Frequency Attenuation Connector (RFAC). It is now in wide use in the U.K. Previously, the disadvantage of RFAC over more conventional methods was its relatively high cost, largely driven by a thick film hybrid circuit used to switch the primary of the transformer. Recently, through a licensing agreement, this technology has been transferred to the U.S. and significant cost reductions and performance improvements have been achieved by the introduction of analog integrated circuits. An integrated circuit performs the following functions: (1) Chops the DC input to a signal suitable for driving the primary of the transformer; (2) Verifies the input voltage is above a threshold; (3) Verifies the input voltage is valid for a pre set time before enabling the device; (4) Provides thermal protection of the circuit; and (5) Provides an external input for independent logic level enabling of the power transfer mechanism. This paper describes the new RFAC product and its applications.

  16. Insider patent holder licensing in an oligopoly market with different cost structures: Fixed-fee, royalty, and auction

    OpenAIRE

    Ming-Chung Chang

    2010-01-01

    The issue of the optimal licensing contract in firms having different cost structures is studied when the innovator is a producing patent holder who has three alternative licensing strategies, namely, the fixed-fee, royalty rate, and auction strategies. We conclude that the auction licensing strategy is not the best strategy when the innovator is a producing patent holder. This finding differs from that of Kabiraj (2004) where the auction licensing method is the optimal licensing strategy whe...

  17. License plate recognition (phase B).

    Science.gov (United States)

    2010-06-01

    License Plate Recognition (LPR) technology has been used for off-line automobile enforcement purposes. The technology has seen mixed success with correct reading rate as high as 60 to 80% depending on the specific application and environment. This li...

  18. Fast multichannel analog storage system

    International Nuclear Information System (INIS)

    Freytag, D.R.

    1982-11-01

    A Multichannel Analog Storage System based on a commercial 32-channel parallel in/serial out (PISO) analog shift register is described. The basic unit is a single width CAMAC module containing 512 analog cells and the associated logic for data storage and subsequent readout. At sampling rates of up to 30 MHz the signals are strobed directly into the PISO. At higher rates signals are strobed into a fast presampling stage and subsequently transferred in block form into an array of PISO's. Sampling rates of 300 MHz have been achieved with the present device and 1000 MHz are possible with improved signal drivers. The system is well suited for simultaneous handling of many signal channels with moderate numbers of samples in each channel. RMS noise over full scale signal has been measured as 1:3000 (approx. = 11 bit). However, nonlinearities in the response and differences in sensitivity of the analog cells require an elaborate calibration system in order to realize 11 bit accuracy for the analog information

  19. Licensing of nuclear reactor operators

    International Nuclear Information System (INIS)

    1979-09-01

    Recommendations are presented for the licensing of nuclear reactor operators in units licensed according to the legislation in effect. They apply to all physical persons designated by the Operating Organization of the nuclear reactor or reactors to execute any of the following functional activities: a) to manipulate the controls of a definite reactor b) to direct the authorized activities of the reactor operators licesed according to the present recommendations. (F.E.) [pt

  20. Molecular interactions between (--epigallocatechin gallate analogs and pancreatic lipase.

    Directory of Open Access Journals (Sweden)

    Shihui Wang

    Full Text Available The molecular interactions between pancreatic lipase (PL and four tea polyphenols (EGCG analogs, like (--epigallocatechin gallate (EGCG, (--gallocatechin gallate (GCG, (--epicatechin gallate (ECG, and (--epigallocatechin (EC, were studied from PL activity, conformation, kinetics and thermodynamics. It was observed that EGCG analogs inhibited PL activity, and their inhibitory rates decreased by the order of EGCG>GCG>ECG>EC. PL activity at first decreased rapidly and then slowly with the increase of EGCG analogs concentrations. α-Helix content of PL secondary structure decreased dependent on EGCG analogs concentration by the order of EGCG>GCG>ECG>EC. EGCG, ECG, and EC could quench PL fluorescence both dynamically and statically, while GCG only quenched statically. EGCG analogs would induce PL self-assembly into complexes and the hydrodynamic radii of the complexes possessed a close relationship with the inhibitory rates. Kinetics analysis showed that EGCG analogs non-competitively inhibited PL activity and did not bind to PL catalytic site. DSC measurement revealed that EGCG analogs decreased the transition midpoint temperature of PL enzyme, suggesting that these compounds reduced PL enzyme thermostability. In vitro renaturation through urea solution indicated that interactions between PL and EGCG analogs were weak and non-covalent.

  1. Analogical reasoning and aging: the processing speed and inhibition hypothesis.

    Science.gov (United States)

    Bugaiska, Aurélia; Thibaut, Jean-Pierre

    2015-01-01

    This study was designed to investigate the effect of aging on analogical reasoning by manipulating the strength of semantic association (LowAssoc or HighAssoc) and the number of distracters' semantic analogies of the A:B::C:D type and to determine which factors might be responsible for the age-related differences on analogical reasoning by testing two different theoretical frameworks: the inhibition hypothesis and the speed mediation hypothesis. We compared young adults and two groups of aging people (old and old-old) with word analogies of the A:B::C:D format. Results indicate an age-related effect on analogical reasoning, this effect being greatest with LowAssoc analogies. It was not associated with the presence of semantic distractors. Moreover, the results show that the variance part of the analogy task due to age was mainly explained by processing speed (rather than by inhibition) in the case of old participants and by both processing speed and inhibition in the old-old group. These results are discussed in relation to current models of aging and their interaction with the processes involved in analogical reasoning.

  2. Postulated licensing schedule for an independent spent-fuel-storage installation

    International Nuclear Information System (INIS)

    Ludwick, J.D.

    1982-11-01

    A review of licensing requirements, processes, and anticipated actions for independent spent fuel storage installations (ISFSIs) was conducted in order to develop an estimated schedule and sequence of events for licensing a new ISFSI. This estimate will be useful to potential ISFSI owners in planning for the licensing of their facilities. It is concluded that, although many uncertainties exist with respect to such things as legal appeals, about 29 months are estimated to elapse between license application and license issuance for an ISFSI. This estimate is in reasonable agreement with a previous time estimate for licensing an ISFSI, and, taking into account the special circumstances involved, with the actual licensing schedule for the GE-Morris ISFSI. However, individual portions of the licensing schedule from each case studied sometimes vary significantly

  3. The USNCR license renewal process

    International Nuclear Information System (INIS)

    Kuo, Pao-Tsin

    2002-01-01

    The US Congress promulgated a law in 1954, entitled 'Atomic Energy Act'. This Act states that operating licenses for commercial nuclear power plants are limited to a fixed term of 40 years, but they may be renewed for a period not to exceed 20 years. The terms were established mainly for economic considerations, not based on technical limitations. The U.S. Nuclear Regulatory Commission (USNRC) published the license renewal rule, Title 10 of the Code of Federal Regulations, Part 54 (10 CFR Part 54), in December, 1991. The rule has since been amended in May, 1995. The underlying principle of the rule is that the regulatory process is adequate for ensuring safety of operating plants. The regulatory process includes NRC's issuance of Orders, Bulletins, Generic Letters, and Information Notices, as well as a number of special inspections in addition to the continuous oversight and routine inspection activities performed by on-site inspectors. Because of this comprehensive regulatory process, compilation of the current license basis or re-verification of the current licensing basis is not considered necessary for a license renewal review. The USNRC also determined on the basis of the findings of its research programs that active structures and components are well maintained by the existing programs. Therefore, the focus of the license renewal review is on passive, long-lived structures and components and on time-limited ageing analyses. The time-limited ageing analyses are for those structures and components which were originally designed to a 40 year service life

  4. Analog electronics for radiation detection

    CERN Document Server

    2016-01-01

    Analog Electronics for Radiation Detection showcases the latest advances in readout electronics for particle, or radiation, detectors. Featuring chapters written by international experts in their respective fields, this authoritative text: Defines the main design parameters of front-end circuitry developed in microelectronics technologies Explains the basis for the use of complementary metal oxide semiconductor (CMOS) image sensors for the detection of charged particles and other non-consumer applications Delivers an in-depth review of analog-to-digital converters (ADCs), evaluating the pros and cons of ADCs integrated at the pixel, column, and per-chip levels Describes incremental sigma delta ADCs, time-to-digital converter (TDC) architectures, and digital pulse-processing techniques complementary to analog processing Examines the fundamental parameters and front-end types associated with silicon photomultipliers used for single visible-light photon detection Discusses pixel sensors ...

  5. Essays on the economics of licensing nuclear power plants

    International Nuclear Information System (INIS)

    Cohen, L.R.

    1979-01-01

    Regulation and licensing of nuclear power plants by the United States Atomic Energy Commission and the United States Nuclear Regulatory Commission are discussed. Chapter 1 overviews the licensing process and issues raised in licensing cases. Based on a sample of plants licensed between 1967 and 1978, a statistical study of the impact of public participation in licensing is performed. The study concludes that public participation has had a major impact on licensing and power-plant costs. The impact is due to a fundamental weakness of the Commissions: their inability to resolve certain issues related to acceptable social risk. The study has important policy implications for reforming the Federal licensing process. Chapter 2 contains an analysis of the Price-Anderson Act, a Federal program for compensating victims of large nuclear accidents. The Price-Anderson Act is placed within the context of generalized federal disaster relief. A model is developed that allows an evaluation programs on the basis of moral hazard and equity principles. Chapter 3 analyzes the Nuclear Regulatory Commission's treatment of its mandatory antitrust review of applicants for nuclear power plants. The main conclusion of the chapter is that the reviews have not addressed the central economic issues of antitrust that are relevant to nuclear power. Instead, the reviews contribute to further cartelization of the electric utility industry. While politically expedient, the reviews are counter-productive to the development of an optimal industry structure

  6. Study of the National Science Foundation's South Pole Station as an analogous data base for the logistical support of a Moon laboratory

    Science.gov (United States)

    Hickam, H. H., Jr.

    1993-01-01

    The day will come when the United States will want to return to the Earth's Moon. When that occurs, NASA may look to the Apollo program for technical and inspirational guidance. The Apollo program, however, was designed to be an end to itself--the landing of a man on the Moon and his return safely within the decade of the 1960's. When that was accomplished, the program folded because it was not self-sustaining. The next time we return to the Moon, we should base our planning on a program that is designed to be a sustained effort for an indefinite period. It is the thrust of this report that the South Pole Station of the National Science Foundation can be used to develop analogs for the construction, funding, and logistical support of a lunar base. Other analogs include transportation and national efforts versus international cooperation. A recommended lunar base using the South Pole Station as inspiration is provided, as well as details concerning economical construction of the base over a 22-year period.

  7. Managing Licensing in a Market for Technology

    DEFF Research Database (Denmark)

    Arora, Ashish; Rønde, Thomas; Fosfuri, Andrea

    the technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend upon product market performance. If licensing is decentralized, the business unit forgoes valuable...

  8. Managing Licensing in a Market for Technology

    DEFF Research Database (Denmark)

    Arora, Ashish; Fosfuri, Andrea; Rønde, Thomas

    2013-01-01

    the technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend on product market performance. If licensing is decentralized, the business unit forgoes valuable...

  9. 31 CFR 536.100 - Licensing procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Licensing procedures. 536.100 Section... This Part to Other Laws and Regulations § 536.100 Licensing procedures. For provisions relating to licensing procedures, see part 501, subpart E, of this chapter. Licensing actions taken pursuant to part 501...

  10. 37 CFR 404.6 - Nonexclusive licenses.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Nonexclusive licenses. 404.6 Section 404.6 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR TECHNOLOGY POLICY, DEPARTMENT OF COMMERCE LICENSING OF GOVERNMENT OWNED INVENTIONS § 404.6 Nonexclusive licenses. Nonexclusive licenses may...

  11. To License or Not to License Remanufacturing Business?

    Directory of Open Access Journals (Sweden)

    Zu-Jun Ma

    2018-01-01

    Full Text Available Many original equipment manufacturers (OEMs face the choice of whether to license an independent remanufacturer (IR to remanufacture their used products. In this paper, we develop closed-loop supply chain models with licensed and unlicensed remanufacturing operations to analyze the competition and cooperation between an OEM and an IR. The OEM sells new products and collects used products through trade-ins, while the IR intercepts the OEM’s cores to produce remanufactured products and sell them in the same market. We derive optimal decisions for each of the two types of firms in licensed and unlicensed remanufacturing scenarios and identify conditions under which the OEM and the IR would be most likely to cooperate with each other in implementing remanufacturing. The results show although it is beneficial for an OEM to license an IR to remanufacture its cores, it is not always necessary for an IR to accept OEM’s authorization. Moreover, we contrast the result for licensed remanufacturing scenario in the decentralized system with that in the centrally coordinated system to quantify potential inefficiency resulting from decentralization of decision making.

  12. 27 CFR 478.95 - Certified copy of license.

    Science.gov (United States)

    2010-04-01

    ... Conduct of Business § 478.95 Certified copy of license. The license furnished to each person licensed... copies of the license to the Chief, Federal Firearms Licensing Center. The request must set forth the...

  13. NASA HRP Immunology Discipline - Use of Terrestrial Analogs

    Science.gov (United States)

    Crucian, Brian

    2014-01-01

    Due to the cost and operational constraints, as well as technical implementation limitations, it is desirous to perform relevant space physiology investigations first in terrestrial 'space analogs'. This is particularly true for initial investigations, which may then provide appropriate focus for subsequent flight investigations, or for mechanistic investigations that simply cannot be performed during spaceflight. Appropriate analog choice is extremely important. There are a wide variety of terrestrial space analogs, each relevant to a particular physiological discipline (or disciplines) and each with a particular fidelity (or lack thereof) to spaceflight, and each with unique operational constraints. The HRP Immunology Discipline is tasked with managing the HRP Risk concerning clinical risk for Astronaut crews related to spaceflight-associated immune dysregulation. Such dysregulation has been documented to occur during spaceflight, and found to persist for the duration of a 6-month ISS mission. Studies continue to characterize the onorbit phenomenon, but it generally consists of diminished immunocyte function, dysregulated cytokine profiles, and persistent herpesvirus reactivation. Causes are thought to synergistically include microgravity, psychological or physiological stress, radiation, and/or circadian misalignment. An appropriate terrestrial analog for immune dysregulation would replicate as many of these influences as possible. Such analogs may include clinostat or bioreactor cell culture (microgravity), hindlimb suspension (stress, fluid shifts, hypokinesis), or human deployment to remote or extreme environments (isolation, stress, circadian). Also, the laboratory setting may be used as an analog, or to augment analogs, such as sleep deprivation/misalignment or human centrifugation to replicate gravitational stress. As an appropriate example of a NASA Disciplines use of Terrestrial space analogs, this talk will discuss spaceflight associated immune

  14. Evaluation of Terminated Nuclear Material Licenses

    International Nuclear Information System (INIS)

    Spencer, K.M.; Zeighami, E.A.

    1999-01-01

    This report presents the results of a six-year project that reviewed material licenses that had been terminated during the period from inception of licensing until approximately late-1994. The material licenses covered in the review project were Part 30, byproduct material licenses; Part 40, source material licenses; and Part 70, special nuclear material licenses. This report describes the methodology developed for the project, summarizes the findings of the license file inventory process, and describes the findings of the reviews or evaluations of the license files. The evaluation identified nuclear material use sites that need review of the licensing material or more direct follow-up of some type. The review process also identified licenses authorized to possess sealed sources for which there was incomplete or missing documentation of the fate of the sources

  15. Heat Transfer Analogies

    International Nuclear Information System (INIS)

    Bhattacharyya, A.

    1965-11-01

    This report contains descriptions of various analogues utilised to study different steady-state and unsteady-state heat transfer problems. The analogues covered are as follows: 1 . Hydraulic: a) water flow b) air flow 2. Membrane 3. Geometric Electrical: a) Electrolytic-tank b) Conducting sheet 4. Network; a) Resistance b) R-C A comparison of the different analogues is presented in the form of a table

  16. 10 CFR 171.15 - Annual fees: Reactor licenses and independent spent fuel storage licenses.

    Science.gov (United States)

    2010-01-01

    ... (non-power) reactor licensed under part 50 of this chapter, unless the reactor is exempted from fees... 10 Energy 2 2010-01-01 2010-01-01 false Annual fees: Reactor licenses and independent spent fuel... REACTOR LICENSES AND FUEL CYCLE LICENSES AND MATERIALS LICENSES, INCLUDING HOLDERS OF CERTIFICATES OF...

  17. 49205 ANALOGE OG DIGITALE FILTRE

    DEFF Research Database (Denmark)

    Gaunholt, Hans

    1997-01-01

    Theese lecture notes treats the fundamental theory and the most commonly used design methods for passive- active and digital filters with special emphasis on microelectronic realizations. The lecture notes covers 75% of the material taught in the course 49205 Analog and Digital Filters...

  18. Drawing Analogies to Deepen Learning

    Science.gov (United States)

    Fava, Michelle

    2017-01-01

    This article offers examples of how drawing can facilitate thinking skills that promote analogical reasoning to enable deeper learning. The instructional design applies cognitive principles, briefly described here. The workshops were developed iteratively, through feedback from student and teacher participants. Elements of the UK National…

  19. CMOS Analog IC Design: Fundamentals

    DEFF Research Database (Denmark)

    Bruun, Erik

    This book is intended for use as the main textbook for an introductory course in CMOS analog integrated circuit design. It is aimed at electronics engineering students who have followed basic courses in mathematics, physics, circuit theory, electronics and signal processing. It takes the students...

  20. Paper Analogies Enhance Biology Teaching.

    Science.gov (United States)

    Stencel, John E.

    1997-01-01

    Describes how to use paper analogies as models to illustrate various concepts in biology, human anatomy, and physiology classes. Models include biochemical paper models, protein papergrams, a paper model of early brain development, and a 3-D paper model of a eukaryotic cell. (AIM)

  1. License application approach for the California LLRW disposal facility

    International Nuclear Information System (INIS)

    Gaynor, R.K.; Romano, S.A.; Hanrahan, T.P.

    1990-01-01

    US Ecology, Inc. is the State of California's license designee to site, develop and operate a low-level radioactive waste (LLRW) disposal facility to serve member states of the Southwestern Compact. US Ecology identified a proposed site in the Ward Valley of southeastern California in March 1988. Following proposed site selection, US Ecology undertook studies required to prepare a license application. US Ecology's license application for this desert site was deemed complete for detailed regulatory review by the California Department of Health Services (DHS) in December 1989. By mutual agreement, disposal of mixed waste is not proposed pending the State of California's decision on appropriate management of this small LLRW subset

  2. Human capital development and a Social License to Operate

    DEFF Research Database (Denmark)

    Smits, Coco C. A.; Justinussen, Jens Christian Svabo; Bertelsen, Rasmus Gjedssø

    2016-01-01

    of a Social License to Operate addresses the acceptance of an activity by local communities and other stakeholders. This manuscript explores the role human capital development in obtaining and maintaining a Social License to Operate in Iceland, the Faroe Islands and Greenland. As trust and legitimacy...... are the two fundamental principles on which a Social License to Operate is based, these are being examined more closely. On the basis of three case studies, this manuscript explores how human capital development can contribute to the legitimacy of Arctic energy development and trust building between various...

  3. Variations in teenage activities with and without a driver's license.

    Science.gov (United States)

    Preusser, D F; Leaf, W A; Ferguson, S A; Williams, A F

    2000-01-01

    High school students were surveyed every 6 months from their freshman through senior years concerning licensing, driving, and transportation to and from their various activities. Students in Delaware (learner's permit can be issued at age 15 years, 10 months; driver's license at age 16) were compared with students in Connecticut and New York (permit at age 16; license at age 16) and in New Jersey (license at age 17). During the junior year, most Delaware students, some New York and Connecticut students, and few New Jersey students were licensed. However, even during the junior year, students in the respective states did not differ significantly with respect to time spent at activities such as a paying job, homework, watching television, dating, parties, being with friends, talking on the phone, or participating in sports or school activities. Graduated licensing systems can delay full-privilege teenage licensure and reduce teenage crash rates. These systems also can increase the number of times parents and others must drive. However, the present study's results indicate that licensing delays of as much as 1 year have minimal effects on the nondriving activities of high school students.

  4. COMPARISON OF CERTAIN ABILITIES NEEDED BY WORKERS IN LICENSED NURSERIES AND LICENSED ORNAMENTAL HORTICULTURE BUSINESSES.

    Science.gov (United States)

    DILLON, ROY D.

    THIS STUDY WAS CONDUCTED TO DETERMINE THE EXTENT TO WHICH WORKERS WITH THE JOB TITLES OF GENERAL DIRECTORS, SALESMEN, SUPERVISORS, AND FIELD WORKERS IN LICENSED NURSERIES NEEDED AGRICULTURALLY ORIENTED KNOWLEDGE OF THE SAME KIND AND LEVEL AS WORKERS IN COMPARABLE JOB TITLES IN ORNAMENTAL HORTICULTURE BUSINESSES. DATA WERE COLLECTED BY PERSONAL…

  5. Licensing reform in the USA

    International Nuclear Information System (INIS)

    1991-01-01

    The licensing process for nuclear power plants in the USA is currently in two distinct stages: the issuance of a construction permit followed later by the issuance of an operation license. The ''two-step'' process has come under heavy criticism from the U.S. nuclear industry on the grounds that it causes uncertainty and delays and therefore inhibits new commitments to nuclear power plants. In 1989 the NRC published new regulations for the licensing of nuclear power plants which provide for the issuance of early site permits, safety certifications of standard designs, and combined construction permits and operating licences. The new rule was challenged by intervenors representing antinuclear groups who filed a legal challenge seeking to have the rule set aside on the grounds that it violates the Atomic Energy Act which they allege makes two-step licensing mandatory. In November 1990 the US Court of Appeals upheld the NRC's authority to issue combined licenses. An appeal for a rehearing has been filed. The paper analyses the events and the possible consequences of an adverse court decision. It reviews the options open to the NRC and industry if the court decision is upheld. The possibility of congressional action to amend the Atomic Energy Act is discussed. (author)

  6. Crows spontaneously exhibit analogical reasoning.

    Science.gov (United States)

    Smirnova, Anna; Zorina, Zoya; Obozova, Tanya; Wasserman, Edward

    2015-01-19

    Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually. In RMTS, choice of test pair BB would be correct if the sample pair were AA, whereas choice of test pair EF would be correct if the sample pair were CD. Critically, no items in the correct test pair physically match items in the sample pair, thus demanding that only relational sameness or differentness is available to support accurate choice responding. Initial evidence suggested that only humans and apes can successfully learn RMTS with pairs of sample and test items; however, monkeys have subsequently done so. Here, we report that crows too exhibit relational matching behavior. Even more importantly, crows spontaneously display relational responding without ever having been trained on RMTS; they had only been trained on identity matching-to-sample (IMTS). Such robust and uninstructed relational matching behavior represents the most convincing evidence yet of analogical reasoning in a nonprimate species, as apes alone have spontaneously exhibited RMTS behavior after only IMTS training. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Generating explanations via analogical comparison.

    Science.gov (United States)

    Hoyos, Christian; Gentner, Dedre

    2017-10-01

    Generating explanations can be highly effective in promoting learning in both adults and children. Our interest is in the mechanisms that underlie this effect and in whether and how they operate in early learning. In adult reasoning, explanation may call on many subprocesses-including comparison, counterfactual reasoning, and reasoning by exclusion; but it is unlikely that all these processes are available to young children. We propose that one process that may serve both children and adults is comparison. In this study, we asked whether children would use the results of a comparison experience when asked to explain why a model skyscraper was stable. We focused on a challenging principle-that diagonal cross-bracing lends stability to physical structures (Gentner et al., Cognitive Science, 40, 224-240, 2016). Six-year-olds either received no training or interacted with model skyscrapers in one of three different conditions, designed to vary in their potential to invite and support comparison. In the Single Model condition, children interacted with a single braced model. In the comparison conditions (Low Alignability and High Alignability), children compared braced and unbraced models. Following experience with the models, children were asked to explain why the braced model was stable. They then received two transfer tasks. We found that children who received highly alignable pairs were most likely to (a) produce brace-based explanations and (b) transfer the brace principle to a dissimilar context. This provides evidence that children can benefit from analogical comparison in generating explanations and also suggests limitations on this ability.

  8. Development of Venus Balloon Seismology Missions Through Earth Analog Experiments

    Science.gov (United States)

    Krishnamoorthy, S.; Komjathy, A.; Cutts, J. A.; Pauken, M. T.; Garcia, R. F.; Mimoun, D.; Jackson, J. M.; Kedar, S.; Smrekar, S. E.; Hall, J. L.

    2017-11-01

    The study of a planet’s seismic activity is central to the understanding of its internal structure. We discuss advances made through Earth analog testing for performing remote seismology on Venus using balloons floated in the mid-atmosphere.

  9. Systems engineering and the licensing of Small Modular Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Kulesa, T., E-mail: tkulesa@us.ibm.com [IBM, Philidelphia, Pennsylvania (United States); Soderholm, K., E-mail: Kristiina.Soderholm@fortum.com [Fortum Power (Finland); Fechtelkotter, P., E-mail: pfech@us.ibm.com [IBM, Boston, Massacheusets (United States)

    2014-07-01

    Both global warming and the need for dependable sources of energy continue to make nuclear power generation an appealing option. But a history of cost overruns, project delays, and environmental disaster has pushed the industry to innovate and design a more flexible, scalable, and safe source of nuclear energy - the small modular reactor. Innovation in generation technology creates disruption in already complex licensing and regulatory processes. This paper discusses how the application of systems engineering and requirements management can help combat confusion, rework, and efficiency problems across the engineering and compliance life cycle. The paper is based on the PhD Dissertation 'Licensing Model Development for Small Modular Reactors (SMRs) - Focusing on Finnish Regulatory Framework', approved in 2013. The result of the study gives recommendations and tools to develop and optimize the licensing process for SMRs. The most important SMR-specific feature, in terms of licensing, is the modularity of the design. Here the modularity indicates multi-module SMR designs, which creates new challenges in the licensing process. Another feature impacting licensing feasibility is the plan to build many standardized power plants in series and use factory-fabricated modules to optimize the construction costs. SMR licensing challenges are under discussion in many international forums, such as World Nuclear Association Cooperation in Reactor Design Evaluation and Licensing Small Modular Reactor group (WNA CORDEL SMR) group and IAEA INPRO regulators' forum. This paper also presents an application of the new licensing process using Systems Engineering, Requirements Management, and Project Management practices and tools. (author)

  10. The time factor in environmental licensing procedures

    International Nuclear Information System (INIS)

    Rombach, P.

    2000-01-01

    The speed of planning and licensing procedures play a large part in the severity of Germany an attractive business location. A comparison is made between licensing procedures in Germany and abroad, whether they take longer and if so, how much; case studies one used as comparable illustrations of construction-, emission-, and waste-regulatory procedures in Germany, France and the USA. The second main part concerns the analysis of the fundamental delaying factors and comentional acceleration instruments in Germany. Applications, effectiveness and reliability of the new concepts (official Projectmanagenment, conflicts of interest, updating of the InvErl- and WohnbaulandG) as well as alternative proposals are developed on the basis of experiences in France and the USA. (orig./HP) [de

  11. Nuclear power plant operator licensing

    International Nuclear Information System (INIS)

    1997-01-01

    The guide applies to the nuclear power plant operator licensing procedure referred to the section 128 of the Finnish Nuclear Energy Degree. The licensing procedure applies to shift supervisors and those operators of the shift teams of nuclear power plant units who manipulate the controls of nuclear power plants systems in the main control room. The qualification requirements presented in the guide also apply to nuclear safety engineers who work in the main control room and provide support to the shift supervisors, operation engineers who are the immediate superiors of shift supervisors, heads of the operational planning units and simulator instructors. The operator licensing procedure for other nuclear facilities are decided case by case. The requirements for the basic education, work experience and the initial, refresher and complementary training of nuclear power plant operating personnel are presented in the YVL guide 1.7. (2 refs.)

  12. NRC licensing requirements: DOD options

    International Nuclear Information System (INIS)

    Pike, W.J.; O'Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with 90 Sr or 238 Pu; radioisotopic dynamic electric generators with 90 Sr or 238 Pu; and applications of radioisotopes for luminous sources (lights) with 3 H, 85 Kr, or 147 Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process

  13. NRC licensing requirements: DOD options

    Energy Technology Data Exchange (ETDEWEB)

    Pike, W.J.; O' Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with /sup 90/Sr or /sup 238/Pu; radioisotopic dynamic electric generators with /sup 90/Sr or /sup 238/Pu; and applications of radioisotopes for luminous sources (lights) with /sup 3/H, /sup 85/Kr, or /sup 147/Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process.

  14. Concept Confusion and Concept Discernment in Basic Magnetism Using Analogical Reasoning

    Science.gov (United States)

    Lemmer, Miriam; Morabe, Olebogeng Nicodimus

    2017-01-01

    Analogical reasoning is central to all learning, whether in daily life situations, in the classroom or while doing research. Although analogies can aid the learning process of making sense of phenomena and understanding new ideas in terms of known ideas, these should be used with care. This article reports a study of the use of analogies and the…

  15. Individual differences in spontaneous analogical transfer.

    Science.gov (United States)

    Kubricht, James R; Lu, Hongjing; Holyoak, Keith J

    2017-05-01

    Research on analogical problem solving has shown that people often fail to spontaneously notice the relevance of a semantically remote source analog when solving a target problem, although they are able to form mappings and derive inferences when given a hint to recall the source. Relatively little work has investigated possible individual differences that predict spontaneous transfer, or how such differences may interact with interventions that facilitate transfer. In this study, fluid intelligence was measured for participants in an analogical problem-solving task, using an abridged version of the Raven's Progressive Matrices (RPM) test. In two experiments, we systematically compared the effect of augmenting verbal descriptions of the source with animations or static diagrams. Solution rates to Duncker's radiation problem were measured across varying source presentation conditions, and participants' understanding of the relevant source material was assessed. The pattern of transfer was best fit by a moderated mediation model: the positive impact of fluid intelligence on spontaneous transfer was mediated by its influence on source comprehension; however, this path was in turn modulated by provision of a supplemental animation via its influence on comprehension of the source. Animated source depictions were most beneficial in facilitating spontaneous transfer for those participants with low scores on the fluid intelligence measure.

  16. Eye Movements Reveal Optimal Strategies for Analogical Reasoning.

    Science.gov (United States)

    Vendetti, Michael S; Starr, Ariel; Johnson, Elizabeth L; Modavi, Kiana; Bunge, Silvia A

    2017-01-01

    Analogical reasoning refers to the process of drawing inferences on the basis of the relational similarity between two domains. Although this complex cognitive ability has been the focus of inquiry for many years, most models rely on measures that cannot capture individuals' thought processes moment by moment. In the present study, we used participants' eye movements to investigate reasoning strategies in real time while solving visual propositional analogy problems (A:B::C:D). We included both a semantic and a perceptual lure on every trial to determine how these types of distracting information influence reasoning strategies. Participants spent more time fixating the analogy terms and the target relative to the other response choices, and made more saccades between the A and B items than between any other items. Participants' eyes were initially drawn to perceptual lures when looking at response choices, but they nonetheless performed the task accurately. We used participants' gaze sequences to classify each trial as representing one of three classic analogy problem solving strategies and related strategy usage to analogical reasoning performance. A project-first strategy, in which participants first extrapolate the relation between the AB pair and then generalize that relation for the C item, was both the most commonly used strategy as well as the optimal strategy for solving visual analogy problems. These findings provide new insight into the role of strategic processing in analogical problem solving.

  17. Eye Movements Reveal Optimal Strategies for Analogical Reasoning

    Directory of Open Access Journals (Sweden)

    Michael S. Vendetti

    2017-06-01

    Full Text Available Analogical reasoning refers to the process of drawing inferences on the basis of the relational similarity between two domains. Although this complex cognitive ability has been the focus of inquiry for many years, most models rely on measures that cannot capture individuals' thought processes moment by moment. In the present study, we used participants' eye movements to investigate reasoning strategies in real time while solving visual propositional analogy problems (A:B::C:D. We included both a semantic and a perceptual lure on every trial to determine how these types of distracting information influence reasoning strategies. Participants spent more time fixating the analogy terms and the target relative to the other response choices, and made more saccades between the A and B items than between any other items. Participants' eyes were initially drawn to perceptual lures when looking at response choices, but they nonetheless performed the task accurately. We used participants' gaze sequences to classify each trial as representing one of three classic analogy problem solving strategies and related strategy usage to analogical reasoning performance. A project-first strategy, in which participants first extrapolate the relation between the AB pair and then generalize that relation for the C item, was both the most commonly used strategy as well as the optimal strategy for solving visual analogy problems. These findings provide new insight into the role of strategic processing in analogical problem solving.

  18. Analog circuit design art, science and personalities

    CERN Document Server

    Williams, Jim

    1991-01-01

    This book is far more than just another tutorial or reference guide - it's a tour through the world of analog design, combining theory and applications with the philosophies behind the design process. Readers will learn how leading analog circuit designers approach problems and how they think about solutions to those problems. They'll also learn about the `analog way' - a broad, flexible method of thinking about analog design tasks.A comprehensive and useful guide to analog theory and applications. Covers visualizing the operation of analog circuits. Looks at how to rap

  19. Consistency Versus Licensing Effects of Past Moral Behavior.

    Science.gov (United States)

    Mullen, Elizabeth; Monin, Benoît

    2016-01-01

    Why does past moral behavior sometimes lead people to do more of the same (consistency), whereas sometimes it liberates them to do the opposite (licensing)? We organize the literature on moderators of moral consistency versus licensing effects using five conceptual themes: construal level, progress versus commitment, identification, value reflection, and ambiguity. Our review reveals that individuals are more likely to exhibit consistency when they focus abstractly on the connection between their initial behavior and their values, whereas they are more likely to exhibit licensing when they think concretely about what they have accomplished with their initial behavior-as long as the second behavior does not blatantly threaten a cherished identity. Moreover, many studies lacked baseline conditions ("donut" designs), leaving it ambiguous whether licensing was observed. And although many proposed moderators yielded significant interactions, evidence for both significant consistency and balancing simple effects in the same study was nearly nonexistent.

  20. Generic environmental impact statement for license renewal of nuclear plants

    International Nuclear Information System (INIS)

    1996-05-01

    Volume 2 of the Generic Environmental Impact Statement for License Renewal of Nuclear Plants contains the appendices. These include: (A) General characterisitics and environmental settings of domestic nuclear plants, (B) Definition of impact initiators, (C) Socioeconomics and case studies, (D) Aquatic organisms and human health, (E) Radiation protection considerations, (F) Methodology for assessing impacts to aquatic ecology and water resources, (G) Postulated accidents, and (H) Environmental statutes and regulations affecting license renewal

  1. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel

    2017-01-01

    This textbook is appropriate for use in graduate-level curricula in analog-to-digital conversion, as well as for practicing engineers in need of a state-of-the-art reference on data converters. It discusses various analog-to-digital conversion principles, including sampling, quantization, reference generation, nyquist architectures and sigma-delta modulation. This book presents an overview of the state of the art in this field and focuses on issues of optimizing accuracy and speed, while reducing the power level. This new, third edition emphasizes novel calibration concepts, the specific requirements of new systems, the consequences of 22-nm technology and the need for a more statistical approach to accuracy. Pedagogical enhancements to this edition include additional, new exercises, solved examples to introduce all key, new concepts and warnings, remarks and hints, from a practitioner’s perspective, wherever appropriate. Considerable background information and practical tips, from designing a PCB, to lay-o...

  2. Scaling analysis in bepu licensing of LWR

    Energy Technology Data Exchange (ETDEWEB)

    D' auria, Francesco; Lanfredini, Marco; Muellner, Nikolaus [University of Pisa, Pisa (Italy)

    2012-08-15

    'Scaling' plays an important role for safety analyses in the licensing of water cooled nuclear power reactors. Accident analyses, a sub set of safety analyses, is mostly based on nuclear reactor system thermal hydraulics, and therefore based on an adequate experimental data base, and in recent licensing applications, on best estimate computer code calculations. In the field of nuclear reactor technology, only a small set of the needed experiments can be executed at a nuclear power plant; the major part of experiments, either because of economics or because of safety concerns, has to be executed at reduced scale facilities. How to address the scaling issue has been the subject of numerous investigations in the past few decades (a lot of work has been performed in the 80thies and 90thies of the last century), and is still the focus of many scientific studies. The present paper proposes a 'roadmap' to scaling. Key elements are the 'scaling-pyramid', related 'scaling bridges' and a logical path across scaling achievements (which constitute the 'scaling puzzle'). The objective is addressing the scaling issue when demonstrating the applicability of the system codes, the 'key-to-scaling', in the licensing process of a nuclear power plant. The proposed 'road map to scaling' aims at solving the 'scaling puzzle', by introducing a unified approach to the problem.

  3. Scaling analysis in bepu licensing of LWR

    International Nuclear Information System (INIS)

    D'auria, Francesco; Lanfredini, Marco; Muellner, Nikolaus

    2012-01-01

    'Scaling' plays an important role for safety analyses in the licensing of water cooled nuclear power reactors. Accident analyses, a sub set of safety analyses, is mostly based on nuclear reactor system thermal hydraulics, and therefore based on an adequate experimental data base, and in recent licensing applications, on best estimate computer code calculations. In the field of nuclear reactor technology, only a small set of the needed experiments can be executed at a nuclear power plant; the major part of experiments, either because of economics or because of safety concerns, has to be executed at reduced scale facilities. How to address the scaling issue has been the subject of numerous investigations in the past few decades (a lot of work has been performed in the 80thies and 90thies of the last century), and is still the focus of many scientific studies. The present paper proposes a 'roadmap' to scaling. Key elements are the 'scaling-pyramid', related 'scaling bridges' and a logical path across scaling achievements (which constitute the 'scaling puzzle'). The objective is addressing the scaling issue when demonstrating the applicability of the system codes, the 'key-to-scaling', in the licensing process of a nuclear power plant. The proposed 'road map to scaling' aims at solving the 'scaling puzzle', by introducing a unified approach to the problem.

  4. Novel phosphanucleoside analogs of dideoxynucleosides

    Czech Academy of Sciences Publication Activity Database

    Páv, Ondřej; Buděšínský, Miloš; Rosenberg, Ivan

    2017-01-01

    Roč. 73, č. 34 (2017), s. 5220-5228 ISSN 0040-4020 R&D Projects: GA ČR(CZ) GA17-12703S; GA ČR GA13-26526S; GA MZd NV15-31604A Institutional support: RVO:61388963 Keywords : phosphanucleoside * nucleoside analog * ring-closing metathesis * stereoselective hydroboration * chiral resolution Subject RIV: CC - Organic Chemistry OBOR OECD: Organic chemistry Impact factor: 2.651, year: 2016

  5. Electrostatic analogy for symmetron gravity

    Science.gov (United States)

    Ogden, Lillie; Brown, Katherine; Mathur, Harsh; Rovelli, Kevin

    2017-12-01

    The symmetron model is a scalar-tensor theory of gravity with a screening mechanism that suppresses the effect of the symmetron field at high densities characteristic of the Solar System and laboratory scales but allows it to act with gravitational strength at low density on the cosmological scale. We elucidate the screening mechanism by showing that in the quasistatic Newtonian limit there are precise analogies between symmetron gravity and electrostatics for both strong and weak screening. For strong screening we find that large dense bodies behave in a manner analogous to perfect conductors in electrostatics. Based on this analogy we find that the symmetron field exhibits a lightning rod effect wherein the field gradients are enhanced near the ends of pointed or elongated objects. An ellipsoid placed in a uniform symmetron gradient is shown to experience a torque. By symmetry there is no gravitational torque in this case. Hence this effect unmasks the symmetron and might serve as the basis for future laboratory experiments. The symmetron force between a point mass and a large dense body includes a component corresponding to the interaction of the point mass with its image in the larger body. None of these effects have counterparts in the Newtonian limit of Einstein gravity. We discuss the similarities between symmetron gravity and the chameleon model as well as the differences between the two.

  6. Defects and their consequences in the nuclear licensing procedure. A study into the procedure for the elaboration of the 5th part-permit issued to the MOX unit of the Hanau nuclear fuel fabrication plant

    International Nuclear Information System (INIS)

    Lange, K.

    1994-01-01

    The expert opinion presented in the book deals with a nuclear licensing procedure and its specific aspects in terms of the nuclear law and the factual and dogmatic situation. As to the facts, one major peculiarity is stated, namely the close cooperation between the licensing authority and the plant owner applying for the license, and also between the licensing authority and the expert preparing the expert opinion. The expert opinion in this book concretizes essential elements of the nuclear licensing procedure, such as examination of the licensing requirements by the competent authority, the participation of other authorities and departments, the participation of experts, distinctness, submission in writing, detailed explanation. Examining the consequences of non-compliance with any of the procedural provisions however shows that the punishments by the law do not really bite: defects in a licensing procedure will only in exceptional cases lead to complete or partial invalidity of a licence. Recourse to the courts will be successful only in case of infringement of subjective rights. A licence resulting from a defective licensing procedure can, if at all, only be declared null and void by the licensing authority whose scope of discretion under the Atomic Energy Act is subject only to the Federal Government's power to give instructions to the Land Governments. This makes clear that it is very important to see to it that the licensing authorities strictly adhere to the legal provisions in force governing the administrative licensing procedure. (orig./HSCH) [de

  7. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost Study Groups.

    Science.gov (United States)

    Camras, C B; Alm, A; Watson, P; Stjernschantz, J

    1996-11-01

    To determine efficacy and safety of latanoprost, a prostaglandin analog for glaucoma, during 1 year of treatment. After baseline measurements, 0.005% latanoprost was topically applied once daily for 12 months in patients from Scandinavia, the United Kingdom, and the United States who had elevated intraocular pressure (IOP). Diagnoses included ocular hypertension, chronic open-angle glaucoma, exfoliation syndrome, and pigment dispersion syndrome. Treatment was masked for the first 6 months and open-label during the second 6 months. Of the 272 patients initially enrolled, withdrawals were due to inadequate IOP control (1%), increased iris pigmentation (5%), other ocular problems (3%), systemic medical problems (3%), and nonmedical reasons (14%). Latanoprost significantly (P color. Overall, latanoprost caused a possible or definite increase in iris pigmentation in 12% of the 272 patients, all of whom had multicolored irides at baseline. One half of these patients with increased pigmentation withdrew before completing 1 year of therapy. Visual field, optic disc cupping, visual acuity, refractive error, conjunctival hyperemia, aqueous flare, anterior chamber cellular response, lens examination, blood pressure, heart rate, blood tests, and urinalysis were not appreciably altered. Latanoprost safely and effectively reduces IOP for 1 year in patients of diverse nationalities, providing further evidence for its usefulness in chronic glaucoma therapy.

  8. In-silico Comparative Study and Quantitative Structure-activity Relationship Analysis of Some Structural and Physiochemical Descriptors of Elvitegravir Analogs.

    Science.gov (United States)

    Satpathy, R; Ghosh, S

    2011-07-01

    Elvitegravir is a new-generation drug which acts as an integrase inhibitor of the HIV virus. The potential inhibition has been tested from the clinical trial data. Here the work basically deals with the quantitative structure-activity relationship (QSAR) analysis by considering some of the physiochemical descriptors like molecular weight, logP, molar volume, and structural descriptors like Winers index, and molecular topological index of the drug analogs. The descriptors were calculated from the E-Dragon server and the multiple linear regression equation models were built by using Minitab tools. The different combinations of structural and physiochemical descriptors were considered for model derivation. The best three models were chosen by observing high R-Sq value, high F-value and low residual errors. The P values (regression) for the three models indicates the significance of the considered descriptors.The overall results obtained with these model suggest that for this perticular drug the activity is dependent on physiochemical descriptors.

  9. Bacterial Peptide deformylase inhibition of cyano substituted biaryl analogs: Synthesis, in vitro biological evaluation, molecular docking study and in silico ADME prediction.

    Science.gov (United States)

    Khan, Firoz A Kalam; Patil, Rajendra H; Shinde, Devanand B; Sangshetti, Jaiprakash N

    2016-08-15

    Herein, we report the synthesis and screening of cyano substituted biaryl analogs 5(a-m) as Peptide deformylase (PDF) enzyme inhibitors. The compounds 5a (IC50 value=13.16μM), 5d (IC50 value=15.66μM) and 5j (IC50 value=19.16μM) had shown good PDF inhibition activity. The compounds 5a (MIC range=11.00-15.83μg/mL), 5b (MIC range=23.75-28.50μg/mL) and 5j (MIC range=7.66-16.91μg/mL) had also shown potent antibacterial activity when compared with ciprofloxacin (MIC range=25-50μg/mL). Thus, the active derivatives were not only potent PDF inhibitors but also efficient antibacterial agents. In order to gain more insight on the binding mode of the compounds with PDF, the synthesized compounds 5(a-m) were docked against PDF enzyme of Escherichia coli and compounds exhibited good binding properties. In silico ADME properties of synthesized compounds were also analyzed and showed potential to develop as good oral drug candidates. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Licensing Process for International Projects

    International Nuclear Information System (INIS)

    Raetzke, Christan

    2014-01-01

    Christan Raetzke, lawyer, then outlined why nuclear constructions were always international projects and in which cases it would make sense to also make the licensing process be international. His law consulting firm CONLAR focuses specifically on design review so he could adequately present why an international process would make a lot of sense without being a loss of sovereignty

  11. Cross Domain Analogies for Learning Domain Theories

    National Research Council Canada - National Science Library

    Klenk, Matthew; Forbus, Ken

    2007-01-01

    .... This work describes a method for learning new domain theories by analogy. We use analogies between pairs of problems and worked solutions to create a domain mapping between a familiar and a new domain...

  12. The Development of Analogical Reasoning Processes.

    Science.gov (United States)

    Sternberg, Robert J.; Rifkin, Bathsheva

    1979-01-01

    Two experiments were conducted to test the generalizability to children of a theory of analogical reasoning processes, originally proposed for adults, and to examine the development of analogical reasoning processes in terms of five proposed sources of cognitive development. (MP)

  13. To License or Not to License Revisited: An Examination of State Statutes Regarding Private Investigators and Digital Examiners

    OpenAIRE

    Thomas Lonardo; Doug White; Alan Rea

    2009-01-01

    In this update to the previous year's study, the authors examine statutes that regulate, license, and enforce investigative functions in each US state. After identification and review of Private Investigator licensing requirements, the authors find that very few state statutes explicitly differentiate between Private Investigators and Digital Examiners. After contacting all state agencies the authors present a distinct grouping organizing state approaches to professional Digital Examiner lice...

  14. Managing technology licensing for stochastic R&D: from the perspective of an enterprise information system

    Science.gov (United States)

    Hong, Xianpei; Zhao, Dan; Wang, Zongjun

    2016-10-01

    Enterprise information technology (IT) plays an important role in technology innovation management for high-tech enterprises. However, to date most studies on enterprise technology innovation have assumed that the research and development (R&D) outcome is certain. This assumption does not always hold in practice. Motivated by the current practice of some IT industries, we establish a three-stage duopoly game model, including the R&D stage, the licensing stage and the output stage, to investigate the influence of bargaining power and technology spillover on the optimal licensing policy for the innovating enterprise when the outcome of R&D is uncertain. Our results demonstrate that (1) if the licensor has low (high) bargaining power, fixed-fee (royalty) licensing is always superior to royalty (fixed-fee) licensing to the licensor regardless of technology spillover; (2) if the licensor has moderate bargaining power and technology spillover is low (high) as well, fixed-fee (royalty) licensing is superior to royalty (fixed-fee) licensing; (3) under two-part tariff licensing and the assumption of licensors with full bargaining power, if a negative prepaid fixed fee is not allowed, two-part tariff licensing is equivalent to royalty licensing which is the optimal licensing policy; if negative prepaid fixed fee is allowed, the optimal policy is two-part tariff licensing.

  15. High fluid intelligence and analogical reasoning

    OpenAIRE

    Preusse, Franziska

    2011-01-01

    Hitherto, previous studies on the cerebral correlates of fluid intelligence (fluIQ) used tasks that did not exclusively demand fluIQ, or were restricted to participants of average fluIQ (ave-fluIQ) solving intelligence test items of varying difficulty, thus not allowing assumptions on interindividual differences in fluIQ. Geometric analogical reasoning (GAR) demands fluIQ very purely and thus is an eligible approach for research on interindividual differences in fluIQ. In a first study, we ...

  16. Science Teachers' Analogical Reasoning

    Science.gov (United States)

    Mozzer, Nilmara Braga; Justi, Rosária

    2013-01-01

    Analogies can play a relevant role in students' learning. However, for the effective use of analogies, teachers should not only have a well-prepared repertoire of validated analogies, which could serve as bridges between the students' prior knowledge and the scientific knowledge they desire them to understand, but also know how to…

  17. The Micro-Category Account of Analogy

    Science.gov (United States)

    Green, Adam E.; Fugelsang, Jonathan A.; Kraemer, David J. M.; Dunbar, Kevin N.

    2008-01-01

    Here, we investigate how activation of mental representations of categories during analogical reasoning influences subsequent cognitive processing. Specifically, we present and test the central predictions of the "Micro-Category" account of analogy. This account emphasizes the role of categories in aligning terms for analogical mapping. In a…

  18. Software approach to automatic patching of analog computer

    Science.gov (United States)

    1973-01-01

    The Automatic Patching Verification program (APV) is described which provides the hybrid computer programmer with a convenient method of performing a static check of the analog portion of his study. The static check insures that the program is patched as specified, and that the computing components being used are operating correctly. The APV language the programmer uses to specify his conditions and interconnections is similar to the FORTRAN language in syntax. The APV control program reads APV source program statements from an assigned input device. Each source program statement is processed immediately after it is read. A statement may select an analog console, set an analog mode, set a potentiometer or DAC, or read from the analog console and perform a test. Statements are read and processed sequentially. If an error condition is detected, an output occurs on an assigned output device. When an end statement is read, the test is terminated.

  19. Interaction of algorithm and implementation for analog VLSI stereo vision

    Science.gov (United States)

    Hakkarainen, J. M.; Little, James J.; Lee, Hae-Seung; Wyatt, John L., Jr.

    1991-07-01

    Design of a high-speed stereo vision system in analog VLSI technology is reported. The goal is to determine how the advantages of analog VLSI--small area, high speed, and low power-- can be exploited, and how the effects of its principal disadvantages--limited accuracy, inflexibility, and lack of storage capacity--can be minimized. Three stereo algorithms are considered, and a simulation study is presented to examine details of the interaction between algorithm and analog VLSI implementation. The Marr-Poggio-Drumheller algorithm is shown to be best suited for analog VLSI implementation. A CCD/CMOS stereo system implementation is proposed, capable of operation at 6000 image frame pairs per second for 48 X 48 images, and faster than frame rate operation on 256 X 256 binocular image pairs.

  20. List of Nuclear Materials Licensing Actions Received

    Data.gov (United States)

    Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

  1. Guide to request license for teletherapy practice

    International Nuclear Information System (INIS)

    2000-01-01

    In this work the steps to request license for teletherapy practice are described , among these steps they it continued it plows to request the qualified personnel's yams, the operation authorization, application purpose, license type

  2. Trends in Hepatitis B Virus Resistance to Nucleoside/Nucleotide Analogs in North China from 2009 to 2016: A Retrospective Study.

    Science.gov (United States)

    Guo, Xianghua; Wu, Jushan; Wei, Feili; Ouyang, Yabo; Li, Qing; Liu, Kai; Wang, Yanjun; Zhang, Yulin; Chen, Dexi

    2018-04-11

    Nucleos(t)ide analogs (NAs) are widely used in anti-hepatitis B virus (HBV) therapy for effective inhibition of HBV replication. However, HBV resistance to NAs has emerged, resulting in virus reactivation and disease recurrence. Big data on the current dynamic of HBV resistance profiles are still rare in China. Herein, we analyzed 4,491 plasma samples with HBV primary genotypic resistance mutations representative of the general HBV resistance situation in northern China from 2009 to 2016. We found that entecavir (ETV), representing 52.8% of 12,713 NAs users in the North of China in 2016, has become the major NA for treating Chinese patients infected with HBV. Despite more than 50% of M204I/V±L180M among all HBV resistance cases annually and extensive exposure of the patients to lamivudine (LAM), telbivudine (LdT), and adefovir dipivoxil (ADV), ETV resistance also showed dramatically increased incidence, which climbed to 17.1% in 2016. Moreover, A181T/V, ETV-resistant mutations, and multidrug-resistant mutations were found more frequently in HBV genotype C than in HBV genotype B, 21.2% vs. 8.5%, 12.5% vs. 7.9%, and 5.9% vs. 3%, respectively, whereas M204I and N236T were more predominant in genotype B than in genotype C, 40.3% vs. 20.8%, and 11.3% vs. 1.8%, respectively. In conclusion, we have reported dynamic changes of HBV NA-resistance mutation patterns and the current NA usage profile for anti-HBV treatment in North China in the past 8 years. Our data provides valuable information on HBV NA resistance that is an important reference for clinics to devise more effective treatment regimens for individual patients. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  3. Folding model study of the charge-exchange scattering to the isobaric analog state and implication for the nuclear symmetry energy

    Energy Technology Data Exchange (ETDEWEB)

    Khoa, Dao T.; Thang, Dang Ngoc [VINATOM, Institute for Nuclear Science and Technique, Hanoi (Viet Nam); Loc, Bui Minh [VINATOM, Institute for Nuclear Science and Technique, Hanoi (Viet Nam); University of Pedagogy, Ho Chi Minh City (Viet Nam)

    2014-02-15

    The Fermi transition (ΔL = ΔS = 0 and ΔT = 1) between the nuclear isobaric analog states (IAS), induced by the charge-exchange (p, n) or ({sup 3}He, t) reaction, can be considered as ''elastic'' scattering of proton or {sup 3}He by the isovector term of the optical potential (OP) that flips the projectile isospin. The accurately measured (p, n) or ({sup 3}He, t) scattering cross section to the IAS can be used, therefore, to probe the isospin dependence of the proton or {sup 3}He optical potential. Within the folding model, the isovector part of the OP is determined exclusively by the neutron-proton difference in the nuclear densities and the isospin dependence of the effective nucleon-nucleon (NN) interaction. Because the isovector coupling explicitly links the isovector part of the proton or {sup 3}He optical potential to the cross section of the charge-exchange (p, n) or ({sup 3}He, t) scattering to the IAS, the isospin dependence of the effective (in-medium) NN interaction can be well tested in the folding model analysis of these charge-exchange reactions. On the other hand, the same isospin- and density-dependent NN interaction can also be used in a Hartree-Fock calculation of asymmetric nuclear matter, to estimate the nuclear matter energy and its asymmetry part (the nuclear symmetry energy). As a result, the fine-tuning of the isospin dependence of the effective NN interaction against the measured (p, n) or ({sup 3}He, t) cross sections should allow us to make some realistic prediction of the nuclear symmetry energy and its density dependence. (orig.)

  4. Folding model study of the charge-exchange scattering to the isobaric analog state and implication for the nuclear symmetry energy

    International Nuclear Information System (INIS)

    Khoa, Dao T.; Thang, Dang Ngoc; Loc, Bui Minh

    2014-01-01

    The Fermi transition (ΔL = ΔS = 0 and ΔT = 1) between the nuclear isobaric analog states (IAS), induced by the charge-exchange (p, n) or ( 3 He, t) reaction, can be considered as ''elastic'' scattering of proton or 3 He by the isovector term of the optical potential (OP) that flips the projectile isospin. The accurately measured (p, n) or ( 3 He, t) scattering cross section to the IAS can be used, therefore, to probe the isospin dependence of the proton or 3 He optical potential. Within the folding model, the isovector part of the OP is determined exclusively by the neutron-proton difference in the nuclear densities and the isospin dependence of the effective nucleon-nucleon (NN) interaction. Because the isovector coupling explicitly links the isovector part of the proton or 3 He optical potential to the cross section of the charge-exchange (p, n) or ( 3 He, t) scattering to the IAS, the isospin dependence of the effective (in-medium) NN interaction can be well tested in the folding model analysis of these charge-exchange reactions. On the other hand, the same isospin- and density-dependent NN interaction can also be used in a Hartree-Fock calculation of asymmetric nuclear matter, to estimate the nuclear matter energy and its asymmetry part (the nuclear symmetry energy). As a result, the fine-tuning of the isospin dependence of the effective NN interaction against the measured (p, n) or ( 3 He, t) cross sections should allow us to make some realistic prediction of the nuclear symmetry energy and its density dependence. (orig.)

  5. The influence of occupational licensing and regulation

    OpenAIRE

    Kleiner, Morris M.

    2017-01-01

    Since the end of World War II, occupational licensing has been one of the fastest growing labor market institutions in the developed world. The economics literature suggests that licensing can influence wage determination, the speed at which workers find employment, pension and health benefits, and prices. Moreover, there is little evidence to show that licensing improves service quality, health, or safety in developed nations. So, why is occupational licensing is growing when there are such ...

  6. 15 CFR 17.1 - Licensing rules.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Licensing rules. 17.1 Section 17.1 Commerce and Foreign Trade Office of the Secretary of Commerce LICENSING OF GOVERNMENT-OWNED INVENTIONS IN THE CUSTODY OF THE DEPARTMENT OF COMMERCE Licensing of Rights in Domestic Patents and Patent Applications § 17.1 Licensing rules. (a) The...

  7. Managing Licensing in a Market for Technology

    OpenAIRE

    Ashish Arora; Andrea Fosfuri; Thomas Roende

    2012-01-01

    Over the last decade, companies have paid greater attention to the management of their intellectual assets. We build a model that helps understand how licensing activity should be organized within large corporations. More specifically, we compare decentralization--where the business unit using the technology makes licensing decisions--to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewar...

  8. Bargaining and delay in patent licensing

    OpenAIRE

    MAULEON, Ana; VANNETELBOSCH, Vincent; VERGARI, Cecilia

    2010-01-01

    We consider a model of licensing of a non-drastic innovation in which the patent holder (an outside innovator) negotiates either up-front fixed fees or per-unit royal- ties with two firms producing horizontally differentiated brands and competing à la Cournot. We investigate how licensing schemes (fixed fee or per-unit royalty) and the number of licenses sold (exclusive licensing or complete technology diffusion) affect price agreements and delays in reaching an agreement. We show that the pa...

  9. Elaborate analogies in science text: Tools for enhancing preservice teachers' knowledge and attitudes

    Science.gov (United States)

    Paris, Nita A.

    2000-11-01

    The present study consisted of two experiments in which the learners read and studied texts about three fundamentally important science concepts. The learners, who were preservice teachers, read a control text with no analogy, a text with a simple analogy, and a text with an elaborate analogy. An elaborate analogy is one that consists of text and pictorial components in which similarities between the analog and the target concept are made explicit. The findings support the use of elaborate analogies in text for improving the science knowledge and attitudes of preservice teachers by relating familiar ideas to new ideas, thereby increasing the relevance and the comprehensibility of the new ideas. Increasing the relevancy of science text by inclusion of an elaborate analogy had an affective, cognitive, and metacognitive impact on learning. Data were examined either by a univariate analysis of variance for repeated measures or a Friedman's test for related samples. These data were supplemented by participants' qualitative responses which were categorized. The results indicated that elaborate analogies in text increased learners' interest in both the conceptual topic of the text and the text itself. Furthermore, the elaborate analogies enhanced learners' science concept learning and inference-making as well. In addition, elaborate analogies increased learners' metacognitive ability to accurately assess their knowledge of science concepts. Finally, elaborate analogies enhanced preservice teachers' self-efficacy for teaching science. The results are consistent with the view that use of analogies to enhance science attitudes and knowledge is inherently constructive in nature. The present findings suggest that current practices of how preservice teachers learn science should be adapted to take advantage of analogies in a more systematic way. Future researchers should investigate the usefulness of elaborate analogies for enhancing metacognition in domain novices and domain

  10. Are all analogies created equal? Prefrontal cortical functioning may predict types of analogical reasoning.

    Science.gov (United States)

    Chrysikou, Evangelia G; Thompson-Schill, Sharon L

    2010-06-01

    Abstract The proposed theory can account for analogies based on learned relationships between elements in the source and target domains. However, its explanatory power regarding the discovery of new relationships during analogical reasoning is limited. We offer an alternative perspective for the role of PFC in analogical thought that may better address different types of analogical mappings.

  11. Application of up-front licensing

    International Nuclear Information System (INIS)

    Grant, S.D.; Snell, V.G.

    1995-01-01

    AECL has been pioneering 'up-front' licensing of new reactor designs. The CANDU 3 design has been formally reviewed by AECB staff for a number of years. The CANDU 9 design has just started the up-front licensing process. The process gives designers, regulators and potential customers early confidence in the licensability of future plants. (author). 4 refs., 2 tabs

  12. 7 CFR 1530.103 - License eligibility.

    Science.gov (United States)

    2010-01-01

    ... license held by an affiliated person. (c) Notwithstanding paragraph (b) of this section, a person who owns one or more wholly-owned subsidiary corporations manufacturing sugar containing products or producing... license. The sum total of license limits for the parent corporation and its wholly-owned subsidiary...

  13. 10 CFR 81.20 - Nonexclusive licenses.

    Science.gov (United States)

    2010-01-01

    ...) The license may extend to wholly-owned subsidiaries of the licensee but shall be nonassignable, or... 10 Energy 2 2010-01-01 2010-01-01 false Nonexclusive licenses. 81.20 Section 81.20 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) STANDARD SPECIFICATIONS FOR THE GRANTING OF PATENT LICENSES Nrc-Owned...

  14. 47 CFR 73.731 - Licensing requirements.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Licensing requirements. 73.731 Section 73.731 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES International Broadcast Stations § 73.731 Licensing requirements. (a) A license for an international broadcasting station will be issued...

  15. 47 CFR 90.1307 - Licensing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Licensing. 90.1307 Section 90.1307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Wireless Broadband Services in the 3650-3700 MHz Band § 90.1307 Licensing. The 3650-3700 MHz band is licensed on the basis of no...

  16. 47 CFR 90.1207 - Licensing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Licensing. 90.1207 Section 90.1207 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Regulations Governing Licensing and Use of Frequencies in the 4940-4990 MHz Band § 90.1207 Licensing. (a) A 4940-4990 MHz band...

  17. 9 CFR 166.10 - Licensing.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Licensing. 166.10 Section 166.10... HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application. Any... regulations. (1) Prior to licensing, each applicant shall demonstrate during an inspection of the premises...

  18. 47 CFR 74.632 - Licensing requirements.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Licensing requirements. 74.632 Section 74.632 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES EXPERIMENTAL RADIO... Stations § 74.632 Licensing requirements. (a) Licenses for television pickup, television STL, television...

  19. 25 CFR 140.12 - License renewal.

    Science.gov (United States)

    2010-04-01

    ... INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES LICENSED INDIAN TRADERS § 140.12 License...-054, through the superintendent, at least 30 days prior to the expiration of the existing license, and the superintendent must report as to the record the applicant has made as a trader and his fitness to...

  20. 25 CFR 11.601 - Marriage licenses.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Marriage licenses. 11.601 Section 11.601 Indians BUREAU... ORDER CODE Domestic Relations § 11.601 Marriage licenses. A marriage license shall be issued by the clerk of the court in the absence of any showing that the proposed marriage would be invalid under any...

  1. Resistive RAMs as analog trimming elements

    Science.gov (United States)

    Aziza, H.; Perez, A.; Portal, J. M.

    2018-04-01

    This work investigates the use of Resistive Random Access Memory (RRAM) as an analog trimming device. The analog storage feature of the RRAM cell is evaluated and the ability of the RRAM to hold several resistance states is exploited to propose analog trim elements. To modulate the memory cell resistance, a series of short programming pulses are applied across the RRAM cell allowing a fine calibration of the RRAM resistance. The RRAM non volatility feature makes the analog device powers up already calibrated for the system in which the analog trimmed structure is embedded. To validate the concept, a test structure consisting of a voltage reference is evaluated.

  2. Analog and mixed-signal electronics

    CERN Document Server

    Stephan, Karl

    2015-01-01

    A practical guide to analog and mixed-signal electronics, with an emphasis on design problems and applications This book provides an in-depth coverage of essential analog and mixed-signal topics such as power amplifiers, active filters, noise and dynamic range, analog-to-digital and digital-to-analog conversion techniques, phase-locked loops, and switching power supplies. Readers will learn the basics of linear systems, types of nonlinearities and their effects, op-amp circuits, the high-gain analog filter-amplifier, and signal generation. The author uses system design examples to motivate

  3. Analog circuit design art, science, and personalities

    CERN Document Server

    Williams, Jim

    1991-01-01

    Analog Circuit Design: Art, Science, and Personalities discusses the many approaches and styles in the practice of analog circuit design. The book is written in an informal yet informative manner, making it easily understandable to those new in the field. The selection covers the definition, history, current practice, and future direction of analog design; the practice proper; and the styles in analog circuit design. The book also includes the problems usually encountered in analog circuit design; approach to feedback loop design; and other different techniques and applications. The text is

  4. Analog to digital conversion for nuclear spectrometry

    International Nuclear Information System (INIS)

    Carvalho, P.V.R. de.

    1982-04-01

    A study of the analog to digital conversion techniques for nuclear spectrometry is presented and the main design philosophies of nuclear ADC's are compared. Among them, the most suitable for the current Brazilian conditions, concerning the specifications and components avaiability is the one that employs a statistical correction of successive approximation converters. This technique is described in full detail. A prototype has been developed an tested for the practical demonstration of the theoretical conclusions. These tests was carried on nuclear spectrometry data aquisition system whose implementation is also described. (Author) [pt

  5. Practical analog electronics for technicians

    CERN Document Server

    Kimber, W A

    2013-01-01

    'Practical Analog Electronics for Technicians' not only provides an accessible introduction to electronics, but also supplies all the problems and practical activities needed to gain hands-on knowledge and experience. This emphasis on practice is surprisingly unusual in electronics texts, and has already gained Will Kimber popularity through the companion volume, 'Practical Digital Electronics for Technicians'. Written to cover the Advanced GNVQ optional unit in electronics, this book is also ideal for BTEC National, A-level electronics and City & Guilds courses. Together with 'Practical Digit

  6. Licensing open spectrum systems

    OpenAIRE

    Vázquez, Miguel Angel; Pérez Neira, Ana Isabel; Lagunas Hernandez, Miguel A.

    2012-01-01

    This paper studies how the spectrum regulation could change in the future open spectrum communication systems. Due to their huge success in short-range communication systems (WiFi, Zigbee, ...), broader area telecommunication providers might mimic the open spectrum philosophy to their systems. Nevertheless, current wireless open spectrum systems are not designed for wide areas and they do not provide QoS to their users. This work proposes an alternative to the nowadays open spectrum systems i...

  7. Licensing process characteristics of Small Modular Reactors and spent nuclear fuel repository

    Energy Technology Data Exchange (ETDEWEB)

    Söderholm, Kristiina, E-mail: kristiina.soderholm@fortum.com [Fortum Power (Finland); Tuunanen, Jari, E-mail: jari.tuunanen@fortum.com [Fortum Power (Finland); Amaba, Ben, E-mail: baamaba@us.ibm.com [IBM Complex Systems (United States); Bergqvist, Sofia, E-mail: sofia.bergqvist@se.ibm.com [IBM Rational Software (Sweden); Lusardi, Paul, E-mail: plusardi@nuscalepower.com [NuScale Power (United States)

    2014-09-15

    Highlights: • We examine the licensing process challenges of modular nuclear facilities. • We compare the features of Small Modular Reactors and spent nuclear fuel repository. • We present the need of nuclear licensing simplification. • Part of the licensing is proposed to be internationally applicable. • Systems engineering and requirements engineering benefits are presented. - Abstract: This paper aims to increase the understanding of the licensing processes characteristics of Small Modular Reactors (SMR) compared with licensing of spent nuclear fuel repository. The basis of the SMR licensing process development lies in licensing processes used in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their various licensing processes and recent actions in the new NPP construction. Certain aspects of the aviation industry licensing process have also been studied and selected practices have been investigated as possibly suitable for use in nuclear licensing. Suitable features for SMR licensing are emphasized and suggested. The licensing features of the spent nuclear fuel deep repository along with similar features of SMR licensing are discussed. Since there are similar types of challenges of lengthy licensing time frames, as well as modular features to be taken into account in licensing, these two different nuclear industry fields can be compared. The main SMR features to take into account in licensing are: • Standardization of the design. • Modularity. • Mass production. • Serial construction. Modularity can be divided into two different categories: the first category is simply a single power plant unit constructed of independently engineered modules (e.g. construction process for Westinghouse AP-1000 NPP) and the second one a power plant composed of many reactor modules, which are manufactured in factories and installed as needed (e.g. NuScale Power SMR design). The deep underground repository

  8. Bupropion Binds to Two Sites in the Torpedo Nicotinic Acetylcholine Receptor Transmembrane Domain: A Photoaffinity Labeling Study with the Bupropion Analog [125I]-SADU-3-72

    Science.gov (United States)

    Pandhare, Akash; Hamouda, Ayman K.; Staggs, Brandon; Aggarwal, Shaili; Duddempudi, Phaneendra K.; Lever, John R.; Lapinsky, David J.; Jansen, Michaela; Cohen, Jonathan B.; Blanton, Michael P.

    2012-01-01

    Bupropion, a clinically-used antidepressant and smoking-cessation drug, acts as a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). To identify its binding site(s) in nAChRs, we developed a photoreactive bupropion analog, (±)-2-(N-tert-butylamino)-3′-[125I]-iodo-4′-azidopropiophenone (SADU-3-72). Based upon inhibition of [125I]SADU-3-72 binding, SADU-3-72 binds with high affinity (IC50 = 0.8 μM) to the Torpedo nAChR in the resting (closed channel) state and in the agonist-induced desensitized state, and bupropion binds to that site with three-fold higher affinity in the desensitized (IC50 = 1.2 μM) than in the resting state. Photolabeling of Torpedo nAChRs with [125I]SADU-3-72 followed by limited in-gel digestion of nAChR subunits with endoproteinase Glu-C established the presence of [125I]SADU-3-72 photoincorporation within nAChR subunit fragments containing M1-M2-M3 helices (αV8-20K, βV8-22/23K and γV8-24K) or M1-M2 helices (δV8-14). Photolabeling within βV8-22/23K, γV8-24K and δV8-14 was reduced in the desensitized state and inhibited by ion channel blockers selective for the resting (tetracaine) or desensitized (thienycyclohexylpiperidine (TCP)) state, and this pharmacologically specific photolabeling was localized to the M2-9 leucine ring (δLeu265, βLeu257) within the ion channel. In contrast, photolabeling within the αV8-20K was enhanced in the desensitized state and not inhibited by TCP, but was inhibited by bupropion. This agonist-enhanced photolabeling was localized to αTyr213 in αM1. These results establish the presence of two distinct bupropion binding sites within the Torpedo nAChR transmembrane domain: a high affinity site at the middle (M2-9) of the ion channel and a second site near the extracellular end of αM1 within a previously described halothane (general anesthetic) binding pocket. PMID:22394379

  9. A heat exchanger analogy of automotive paint ovens

    International Nuclear Information System (INIS)

    Rao, Preetham P.

    2013-01-01

    Computational prediction of vehicle temperatures in an automotive paint oven is essential to predict paint quality and manufacturability. The complex geometry of vehicles, varying scales in the flow, transient nature of the process, and the tightly coupled conjugate heat transfer render the numerical models computationally very expensive. Here, a novel, simplified model of the oven is developed using an analogy to a three-stream cross flow heat exchanger that transfers heat from air to a series of moving bodies and supporting carriers. The analogous heat exchanger equations are developed and solved numerically. Steady state Computational Fluid Dynamics (CFD) simulations are carried out to model the flow field and to extract the heat transfer coefficients around the body and carriers. The air temperature distribution from the CFD models is used as a boundary condition in the analogous model. Correction coefficients are used in the analogy to take care of various assumptions. These are determined from existing test data. The same corrections are used to predict air temperatures for a modified configuration of the oven and a different vehicle. The method can be used to conduct control volume analysis of ovens to determine energy efficiency, and to study new vehicle or oven designs. -- Highlights: • Analogy of an automotive paint oven as a three stream cross flow heat exchanger. • The three streams are vehicle bodies, carriers and hot air. • Convection coefficients and inlet air stream temperatures from steady CFD simulations. • Analogy useful for overall energy efficiency analysis of conveyor ovens in general

  10. Music Licensing Rights and Wrongs

    OpenAIRE

    Jacobsen, Rasmus; Kustková, Zuzana; Løvås, Johanna; Manniche, Ósk; Petersen, Maria; Sandermann, Wiebke; Veitová, Kristyna

    2014-01-01

    The project revolves around the issue of copyright and more specifically playing music in public. To shed light on the issue it uses an exemplary case to illustrate its points. The case is an episode that occurred in 1995 where the American Girl Scouts were asked to pay licenses for public performances at their camps. The specific case was chosen because it has clear contradictions between the aspect of law and the aspect of morality. The ideas of several both contemporary and ...

  11. Reliability of analog quantum simulation

    Energy Technology Data Exchange (ETDEWEB)

    Sarovar, Mohan [Sandia National Laboratories, Digital and Quantum Information Systems, Livermore, CA (United States); Zhang, Jun; Zeng, Lishan [Shanghai Jiao Tong University, Joint Institute of UMich-SJTU, Key Laboratory of System Control and Information Processing (MOE), Shanghai (China)

    2017-12-15

    Analog quantum simulators (AQS) will likely be the first nontrivial application of quantum technology for predictive simulation. However, there remain questions regarding the degree of confidence that can be placed in the results of AQS since they do not naturally incorporate error correction. Specifically, how do we know whether an analog simulation of a quantum model will produce predictions that agree with the ideal model in the presence of inevitable imperfections? At the same time there is a widely held expectation that certain quantum simulation questions will be robust to errors and perturbations in the underlying hardware. Resolving these two points of view is a critical step in making the most of this promising technology. In this work we formalize the notion of AQS reliability by determining sensitivity of AQS outputs to underlying parameters, and formulate conditions for robust simulation. Our approach naturally reveals the importance of model symmetries in dictating the robust properties. To demonstrate the approach, we characterize the robust features of a variety of quantum many-body models. (orig.)

  12. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel J. M

    2013-01-01

    This textbook is appropriate for use in graduate-level curricula in analog to digital conversion, as well as for practicing engineers in need of a state-of-the-art reference on data converters.  It discusses various analog-to-digital conversion principles, including sampling, quantization, reference generation, nyquist architectures and sigma-delta modulation.  This book presents an overview of the state-of-the-art in this field and focuses on issues of optimizing accuracy and speed, while reducing the power level. This new, second edition emphasizes novel calibration concepts, the specific requirements of new systems, the consequences of 45-nm technology and the need for a more statistical approach to accuracy.  Pedagogical enhancements to this edition include more than twice the exercises available in the first edition, solved examples to introduce all key, new concepts and warnings, remarks and hints, from a practitioner’s perspective, wherever appropriate.  Considerable background information and pr...

  13. Analogical reasoning in schizophrenic delusions.

    Science.gov (United States)

    Simpson, Jane; Done, D John

    2004-09-01

    Reasoning ability has often been argued to be impaired in people with schizophrenic delusions, although evidence for this is far from convincing. This experiment examined the analogical reasoning abilities of several groups of patients, including non-deluded and deluded schizophrenics, to test the hypothesis that performance by the deluded schizophrenic group would be impaired. Eleven deluded schizophrenics, 10 depressed subjects, seven non-deluded schizophrenics and 16 matched non-psychiatric controls, who were matched on a number of key variables, were asked to solve an analogical reasoning task. Performance by the deluded schizophrenic group was certainly impaired when compared with the depressed and non-psychiatric control groups though less convincingly so when compared with the non-deluded schizophrenic group. The impairment shown by the deluded schizophrenic group seemed to occur at the initial stage of the reasoning task. The particular type of impairment shown by the deluded subjects was assessed in relation to other cognitive problems already researched and the implications of these problems on reasoning tasks and theories of delusions was discussed.

  14. Licensing of the Ignalina NPP

    International Nuclear Information System (INIS)

    Kutas, S.

    1999-01-01

    Since 1991 State Nuclear Power Safety Inspectorate (VATESI) has regulated Ignalina NPP operation by issuing annual operating permits. Those have been issued following submission of specified documents by the Ignalina NPP that have been reviewed by VATESI. However, according to to the procedures that are now established in the Law on Nuclear Energy and subordinate regulations the use of nuclear energy in the Republic of Lithuania is subject to strict licensing. Therefore a decision about the licence for continued operation of unit 1 should be taken. Licence would be granted by VATESI in cooperation with the Ministry of Health, Ministry of Environment and the institutions of local authorities. Ignalina NPP presented to the VATESI safety analysis report (SAR) with other documents. SAR was made mainly by foreign experts and financed by European Bank for Reconstruction and Development (EBRD). VATESI in this process is supported by western regulators. A special project LAP - Licensing Assistance Project was launched to help VATESI perform licensing according western practices

  15. Asserting the primacy of health over patent rights: a comparative study of the processes that led to the use of compulsory licensing in Thailand and Brazil.

    Science.gov (United States)

    Rosenberg, Stephanie T

    2014-08-01

    Since the 1970s, the United States has adopted a trade policy agenda that has forced countries to trade away flexible patent provisions for access to US markets. While pharmaceutical companies have argued that the recognition of patent rights is essential for recovering investments in research and development of pharmaceuticals and incentivizing future innovation, the lack of competition has had damaging consequences for public health, as companies tend to set the prices of treatments beyond the reach of consumers and government programs. Thailand and Brazil are bound by law to provide universal access to anti-retroviral treatment (ART) to People Living with HIV/AIDS (PLWHA). This has been made possible in part due to the universal health care systems in each country and the countries' local technical and industrial capacities that provide the government with affordable generic medicines. The introduction of stronger intellectual property protection laws however, has limited possibilities for procuring generic medicines and inflated the cost of treatment. Between 2006-2008, Thailand and Brazil used compulsory licensing to authorize generic competition against the consent of the pharmaceutical companies in order to guarantee the right to health and ensure the viability of government health budgets. This paper will demonstrate how the interaction between individual / collective action and structural and institutional elements in Thailand and Brazil produced propitious conditions for each country to assert the primacy of health over patent rights. © 2014 John Wiley & Sons Ltd.

  16. Evaluating the Usefulness of Compulsory Licensing in Developing Countries: A Comparative Study of Thai and Brazilian Experiences Regarding Access to Aids Treatments.

    Science.gov (United States)

    Guennif, Samira

    2017-08-01

    While compulsory licensing (CL) is described in the TRIPS agreement as flexibility to protect public health by improving access to medicines in developing countries, a recent literature contends adversely that CL may harm public health. Therefore, this article intends to evaluate the usefulness of CL in the South through the prism of obligations and goals entrusted to patent holders (the effective and non-abusive exploitation of patents in order to achieve industrial and health developments) and in light of experiences in Thailand and Brazil regarding access to antiretroviral drugs. In this way, it shows that the obligations assigned to patent holders were better served by the recipients of CL and brought significant health and industrial benefits in the two high middle-income countries. In particular, CL allowed the scaling-up of free and universal access to antiretroviral drugs by assuring the financial sustainability of these public health programs endangered by monopolistic practices from patent holders. © 2016 John Wiley & Sons Ltd.

  17. The post-closure radiological safety case for a spent fuel repository in Sweden - An international peer review of the SKB license-application study of March 2011

    International Nuclear Information System (INIS)

    2012-01-01

    Sweden is at the forefront among countries developing plans for a deep geological repository of highly radioactive waste. There is no such repository in operation yet worldwide, but Sweden, Finland and France are approaching the licensing stage. At the request of the Swedish government, the NEA organised an international peer review of the post-closure radiological safety case produced by the Swedish Nuclear Fuel and Waste Management Company (SKB) in support of the application for a general licence to construct and operate a spent nuclear fuel geological repository in the municipality of Oesthammar. The purpose of the review was to help the Swedish government, the public and relevant organisations by providing an international reference regarding the maturity of SKB's spent fuel disposal programme vis-a-vis best practices in long-term disposal safety and radiological protection. The International Review Team (IRT) consisted of ten international specialists, who were free of conflict of interest with the SKB and brought complementary expertise to the review. This report provides the background and findings of the international peer review. The review's findings are presented at several levels of detail in order to be accessible to both specialist and non-specialist readers

  18. SSERVI Analog Regolith Simulant Testbed Facility

    Science.gov (United States)

    Minafra, Joseph; Schmidt, Gregory; Bailey, Brad; Gibbs, Kristina

    2016-10-01

    The Solar System Exploration Research Virtual Institute (SSERVI) at NASA's Ames Research Center in California's Silicon Valley was founded in 2013 to act as a virtual institute that provides interdisciplinary research centered on the goals of its supporting directorates: NASA Science Mission Directorate (SMD) and the Human Exploration & Operations Mission Directorate (HEOMD).Primary research goals of the Institute revolve around the integration of science and exploration to gain knowledge required for the future of human space exploration beyond low Earth orbit. SSERVI intends to leverage existing JSC1A regolith simulant resources into the creation of a regolith simulant testbed facility. The purpose of this testbed concept is to provide the planetary exploration community with a readily available capability to test hardware and conduct research in a large simulant environment.SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers.SSERVI provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment.The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area, including dust mitigation and safety oversight.Facility hardware and environment testing scenarios could include, Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, Surface features (i.e. grades and rocks)Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and

  19. Analog modelling of obduction processes

    Science.gov (United States)

    Agard, P.; Zuo, X.; Funiciello, F.; Bellahsen, N.; Faccenna, C.; Savva, D.

    2012-04-01

    Obduction corresponds to one of plate tectonics oddities, whereby dense, oceanic rocks (ophiolites) are presumably 'thrust' on top of light, continental ones, as for the short-lived, almost synchronous Peri-Arabic obduction (which took place along thousands of km from Turkey to Oman in c. 5-10 Ma). Analog modelling experiments were performed to study the mechanisms of obduction initiation and test various triggering hypotheses (i.e., plate acceleration, slab hitting the 660 km discontinuity, ridge subduction; Agard et al., 2007). The experimental setup comprises (1) an upper mantle, modelled as a low-viscosity transparent Newtonian glucose syrup filling a rigid Plexiglas tank and (2) high-viscosity silicone plates (Rhodrosil Gomme with PDMS iron fillers to reproduce densities of continental or oceanic plates), located at the centre of the tank above the syrup to simulate the subducting and the overriding plates - and avoid friction on the sides of the tank. Convergence is simulated by pushing on a piston at one end of the model with velocities comparable to those of plate tectonics (i.e., in the range 1-10 cm/yr). The reference set-up includes, from one end to the other (~60 cm): (i) the piston, (ii) a continental margin containing a transition zone to the adjacent oceanic plate, (iii) a weakness zone with variable resistance and dip (W), (iv) an oceanic plate - with or without a spreading ridge, (v) a subduction zone (S) dipping away from the piston and (vi) an upper, active continental margin, below which the oceanic plate is being subducted at the start of the experiment (as is known to have been the case in Oman). Several configurations were tested and over thirty different parametric tests were performed. Special emphasis was placed on comparing different types of weakness zone (W) and the extent of mechanical coupling across them, particularly when plates were accelerated. Displacements, together with along-strike and across-strike internal deformation in all

  20. Licensing process for the power increase

    International Nuclear Information System (INIS)

    Perez P, R.; Mamani A, Y.R.; Salgado G, J.R.

    2006-01-01

    The licensing process for the power increase of a nuclear power station is presented, this includes the description of the effective normative framework, the attributions of the one Mexican regulator organism in nuclear matter, the definition and importance of the power level of a nuclear reactor for the safety studies. Also, the types of power increase according to its magnitude, and the regulator process that it includes the scope and the detail of the required information that it should be evaluated by the one regulator organism are discussed. Finally it offers a summary of the experience that one has in Mexico for this type of processes. (Author)