WorldWideScience

Sample records for analog studies licensing

  1. Natural analog studies: Licensing perspective

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J.W. [Nuclear Regulatory Commission, Washington, DC (United States)

    1995-09-01

    This report describes the licensing perspective of the term {open_quotes}natural analog studies{close_quotes} as used in CFR Part 60. It describes the misunderstandings related to its definition which has become evident during discussions at the U.S Nuclear Regulatory Commission meetings and tries to clarify the appropriate applications of natural analog studies to aspects of repository site characterization.

  2. The role of natural analogs in the repository licensing process

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, W.M. [Center for Nuclear Waste Regulatory Analyses, San Antonio, TX (United States)

    1995-09-01

    The concept of a permanent geologic repository for high-level nuclear waste (NLW) is implicitly based on analogy to natural systems that have been stable for millions or billions of years. The time of radioactive and chemical toxicity of HLW exceeds the duration of human civilization, and it is impossible to demonstrate the accuracy of predictions of the behavior of engineered or social systems over such long periods.

  3. Changing mobility patterns and road mortality among pre-license teens in a late licensing country : an epidemiological study.

    NARCIS (Netherlands)

    Twisk, D.A.M. Bos, N.M. Shope, J.T. & Kok, G.

    2013-01-01

    Whereas the safety of teens in early licensing countries has been extensively studied, little is known about the safety of pre-license teens in late licensing countries, where these teens also may be at risk. This risk exists because of the combination of a) increasing use of travel modes with a hig

  4. 75 FR 7469 - Panel Member List for Hydropower Licensing Study Dispute Resolution; Notice Extending Filing Date...

    Science.gov (United States)

    2010-02-19

    ... Energy Regulatory Commission Panel Member List for Hydropower Licensing Study Dispute Resolution; Notice Extending Filing Date for Applications for Panel Member List for Hydropower Licensing Study Dispute... in the Commission's hydropower integrated licensing process (ILP) study dispute resolution...

  5. Natural Analog Studies at Pena Blanca, Mexico

    International Nuclear Information System (INIS)

    The significance of the Pena Blanca uranium deposits in the State of Chihuahua, Mexico as potential natural analogs for a nuclear waste repository in unsaturated welded tuff was first recognized in the 1980s. In the 1970s, the Pena Blanca region was a major target of uranium exploration and exploitation by the Mexican government. Since then the Nopal I uranium deposit has been studied extensively by researchers in the U.S., Mexico, and Europe. The Nopal I deposit represents an environment similar to that of the proposed high-level radioactive waste repository at Yucca Mountain in many ways. Both are located in semi-arid regions. Both are located in Tertiary rhyolitic tuffs overlying carbonate rocks that have been subjected to basin and range-style tectonic deformation. Both are located in a chemically oxidizing, unsaturated zone 200 m or more above the water table. The alteration of uraninite to secondary minerals at Nopal I may be similar to the alteration of uranium fuel rods in this type of setting. Investigations at Nopal I and in the surrounding Sierra Pena Blanca have included detailed outcrop mapping, hydrologic and isotopic studies of flow and transport, studies of mineral alteration, modeling, and performance assessment

  6. Natural Analog Studies at Pena Blanca, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    A.M. Simmons

    2005-07-11

    The significance of the Pena Blanca uranium deposits in the State of Chihuahua, Mexico as potential natural analogs for a nuclear waste repository in unsaturated welded tuff was first recognized in the 1980s. In the 1970s, the Pena Blanca region was a major target of uranium exploration and exploitation by the Mexican government. Since then the Nopal I uranium deposit has been studied extensively by researchers in the U.S., Mexico, and Europe. The Nopal I deposit represents an environment similar to that of the proposed high-level radioactive waste repository at Yucca Mountain in many ways. Both are located in semi-arid regions. Both are located in Tertiary rhyolitic tuffs overlying carbonate rocks that have been subjected to basin and range-style tectonic deformation. Both are located in a chemically oxidizing, unsaturated zone 200 m or more above the water table. The alteration of uraninite to secondary minerals at Nopal I may be similar to the alteration of uranium fuel rods in this type of setting. Investigations at Nopal I and in the surrounding Sierra Pena Blanca have included detailed outcrop mapping, hydrologic and isotopic studies of flow and transport, studies of mineral alteration, modeling, and performance assessment.

  7. Are study strategies related to medical licensing exam performance?

    OpenAIRE

    West, Courtney; Kurz, Terri; Smith, Sherry; Graham, Lori

    2014-01-01

    Objectives: To examine the relationship between study strategies and performance on a high stakes medical licensing exam entitled the United States Medical Licensing Examination Step 1. Methods: The action research project included seventy nine student participants at the Texas A&M Health Science Center College of Medicine during their pre-clinical education. Data collection included pre-matriculation and matriculation academic performance data, standardized exam data, and the Learning and St...

  8. Developing Fluorescent Hyaluronan Analogs for Hyaluronan Studies

    OpenAIRE

    Shi Ke; Arlin G. Cameron; Wei Wang

    2012-01-01

    Two kinds of fluorescent hyaluronan (HA) analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR) dye. At low labeling ratios, the hyaluronan uptake can be directly imaged while at high labeling ratios, the fluorescent signal is quenched and signal generation occur...

  9. Developing Fluorescent Hyaluronan Analogs for Hyaluronan Studies

    Directory of Open Access Journals (Sweden)

    Shi Ke

    2012-02-01

    Full Text Available Two kinds of fluorescent hyaluronan (HA analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR dye. At low labeling ratios, the hyaluronan uptake can be directly imaged while at high labeling ratios, the fluorescent signal is quenched and signal generation occurs only after degradation. It is found that the conjugate containing 1%–2% NIR dye can be used as a normal optical imaging agent, while bioactivable imaging agents are formed at 6% to 17% dye loading. It was determined that the conjugation of dye to HA with different loading percentages does not impact HA biodegradation by hyaluronidase (Hyal. The feasibility of using these two NIR fluorescent hyaluronan analogs for HA investigation was evaluated in vivo with optical imaging. The data demonstrates that the 1% dye loaded fluorescent HA can be used to monitor the behavior of HA and its fragments, whereas bioactivatable HA imaging agent (17% dye in HA is more suitable for detecting HA fragments.

  10. Zwittermicin A: Synthesis of Analogs and Structure-Activity Studies

    OpenAIRE

    Rogers, Evan W.; Dalisay, Doralyn S.; Molinski, Tadeusz F.

    2010-01-01

    Analogs and diastereomers of the natural product zwittermicin A were prepared. SAR studies of these compounds reveal the antifungal activity to be dependent singularly upon the natural constitution and configuration.

  11. European ITER site studies: Lessons learnt in safety and licensing

    International Nuclear Information System (INIS)

    On June 28th 2005, an agreement was reached among the ITER parties on the selection of EU Site of Cadarache in France. In consequence, the ITER generic site safety assessments had to be adapted to the French requirements in order to get the required license. It is precisely in this point that Europe has been working through the European ITER Site Studies contract framework. The main objective: to contribute to the ITER Organization to fulfill in time the deliverable of licensing files to the French authorities. This paper details the gained lessons by the organizations involved in the writing of supporting studies for these licensing files. The lessons learnt tackle a very wide range of technical and strategic aspects, some of them never considered before for a fusion facility. It could be mentioned, for instance, the application of international codes and standards to typical fusion components, the integration of the approach for accident evaluation, the compilation of safety feed-back from fusion experiments, the definition of waste treatment strategies or the incorporation of the human factor in design and operation among others. The effort has involved EFDA, the current F4E organization, EURATOM associations and European industries. Two facts have made specially challenging the task of support the licensing process: ITER being the first fusion reactor to be licensed as Installation Nucleaire de Base and the entry in force of a new nuclear regulation in France. So original and challenging scenario has lead to adaptation strategies and innovative for fusion approaches in safety and licensing studies. (author)

  12. 75 FR 44274 - Prospective Grant of Exclusive License: Use of Leptin and Leptin Analogs for the Treatment of...

    Science.gov (United States)

    2010-07-28

    ... leptin and leptin analogs for the treatment of lipodystrophy or a metabolic condition associated with... acts as an appetite suppressant. Lipodystrophy, a disorder characterized by pathological deposition of... multiple metabolic disorders--extreme insulin resistance, very high triglyceride levels, diabetes...

  13. Changing mobility patterns and road mortality among pre-license teens in a late licensing country : an epidemiological study.

    OpenAIRE

    Twisk, D.A.M. Bos, N.M. Shope, J.T. & Kok, G.

    2013-01-01

    Whereas the safety of teens in early licensing countries has been extensively studied, little is known about the safety of pre-license teens in late licensing countries, where these teens also may be at risk. This risk exists because of the combination of a) increasing use of travel modes with a high injury risk, such as bicycles and mopeds, b) inexperience, and c) teens’ developmental stage, known to be associated with risk taking and novelty seeking, especially among males. To explore the m...

  14. Radiohalogenated amphetamine analogs for blood flow and serotonin receptor studies

    International Nuclear Information System (INIS)

    The 4-radiohalo-2,5-dimethoxyamphetamine hallucinogens were first utilized in the 1970's for cerebral imaging studies by T. Sargent and A.T. Shulgin. Subsequently, other radioiodinated amphetamine analogs and distantly related diamines have been synthesized and used for clinical single photon studies of cerebral blood flow. A generator system for the production of the short-lived positron emitter 122I (3.5 min half-life) was developed, and several amphetamine and diamine compounds have been labeled with 122I for positron emission tomography (PET) studies of regional cerebral blood flow in animals and humans. The short half-life of 122I requires that the radiochemical syntheses be rapid and efficient. Both electrophilic deprotonation and demetallation reactions have been utilized to achieve this goal. Recently, there has been considerable evidence that some 4-halo-2,5-dimethoxyamphetamine analogs are highly specific serotonin receptor agonists. This has lead to the speculation that the binding of these agonists to a serotonin 5-HT2 receptor sub-type may be involved in hallucinogenesis. In an effort to help elucidate the role of these agents, several radioiodinated and radiobrominated 4-halo-2,5-dimethoxyamphetamine analogs have been synthesized for in vitro binding studies. Studies examining the in vivo interaction of these analogs with serotonin 5-HT2 receptors have been initiated with the synthesis of 4-(18F)fluoroalkyl-2,5-dimethoxyamphetamines

  15. Licensing method for new nuclear power plant: A study on decision making modeling

    Energy Technology Data Exchange (ETDEWEB)

    Ramli, N; Ohaga, E. O.; Jung, J. C. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2012-10-15

    This work provides a study on decision making modeling for a licensing method of a new nuclear power plant. SWOT analysis provides the licensing alternatives attributes, then the expectation from either COL or two step licensing method is decided by inputting the output from the Hurwitz mathematical model. From the analysis, COL shows the best candidate for both optimistic and pessimistic conditions.

  16. Licensing method for new nuclear power plant: A study on decision making modeling

    International Nuclear Information System (INIS)

    This work provides a study on decision making modeling for a licensing method of a new nuclear power plant. SWOT analysis provides the licensing alternatives attributes, then the expectation from either COL or two step licensing method is decided by inputting the output from the Hurwitz mathematical model. From the analysis, COL shows the best candidate for both optimistic and pessimistic conditions

  17. Application of natural analog studies to exploration for ore deposits

    International Nuclear Information System (INIS)

    Natural analogs are viewed as similarities in nature and are routinely utilized by exploration geologists in their search for economic mineral deposits. Ore deposit modeling is undertaken by geologists to direct their exploration activities toward favorable geologic environments and, therefore, successful programs. Two types of modeling are presented: (i) empirical model development based on the study of known ore deposit characteristics, and (ii) concept model development based on theoretical considerations and field observations that suggest a new deposit type, not known to exist in nature, may exist and justifies an exploration program. Key elements that are important in empirical model development are described, and examples of successful applications of these natural analogs to exploration are presented. A classical example of successful concept model development, the discovery of the McLaughlin gold mine in California, is presented. The utilization of natural analogs is an important facet of mineral exploration. Natural analogs guide explorationists in their search for new discoveries, increase the probability of success, and may decrease overall exploration expenditure

  18. Application of natural analog studies to exploration for ore deposits

    Energy Technology Data Exchange (ETDEWEB)

    Gustafson, D.L. [Consulting Economic Geologist, Reno, NV (United States)

    1995-09-01

    Natural analogs are viewed as similarities in nature and are routinely utilized by exploration geologists in their search for economic mineral deposits. Ore deposit modeling is undertaken by geologists to direct their exploration activities toward favorable geologic environments and, therefore, successful programs. Two types of modeling are presented: (i) empirical model development based on the study of known ore deposit characteristics, and (ii) concept model development based on theoretical considerations and field observations that suggest a new deposit type, not known to exist in nature, may exist and justifies an exploration program. Key elements that are important in empirical model development are described, and examples of successful applications of these natural analogs to exploration are presented. A classical example of successful concept model development, the discovery of the McLaughlin gold mine in California, is presented. The utilization of natural analogs is an important facet of mineral exploration. Natural analogs guide explorationists in their search for new discoveries, increase the probability of success, and may decrease overall exploration expenditure.

  19. VEHICLE LICENSE PLATE CHARACTER SEGMENTATION – A VEHICLE LICENSE PLATE CHARACTER SEGMENTATION – A STUDY

    Directory of Open Access Journals (Sweden)

    V. Karthi Keyan

    2013-02-01

    Full Text Available License plate recognition (LPR plays a major role in this busy world, as the number of vehicles increases day by day, theft of vehicles, breaking traffic rules, entering restricted area are also increases linearly, so to block this act license plate recognition system is designed. License Plate Recognition (LPR systems basically consist of 3 main processing steps such as: Detection of number plate, Segmentation of plate characters and Recognition of each character. Among this, character segmentation is a most challenging task, as the accuracy of the character recognition relies on the accuracy of the character segmentation. Problems of different lighting condition, adhesion, fracture, rivet, rotation degrades the accuracy of the character segmentation. So in order to overcome these problems and uplift the accuracy of character segmentation various algorithms are developed for this work. Purpose of this paper is to categorize the vehicle plate character and recognize the segmented characters.

  20. The Implementation of Integrated One-Stop Service at Licensing Service Agency in Order to Improve Licensing Service to Society (Case Study On Business License Service At Investment And Integrated Licensing Service Agency (IILSA Of Pasuruan City

    Directory of Open Access Journals (Sweden)

    Priyani Dini Pramita

    2014-10-01

    Full Text Available This study discusses about the implementation of integrated one-stop licensing services related to service of SIUP, conducted by the Investment and Integrated Licensing Service Agency (IILSA in Pasuruan City. In general there are any issues related to License for business activities, namely: the complicated procedures, high costs and legal uncertainty. To overcome this problem the government issued Permendagri number 24 of 2006 about Guidelines for the Implementation of One Stop Services. The focus of this study discusses the implementation of an integrated one-stop service, based on the rules associated with seeing some of the following elements: (1 executing actor (2 communication (3 resources (4 bureaucratic structure (5 the target group. This research used descriptive method with qualitative research approach. Activity of data analysis in this study consisted of data reduction, display and verification of data. The result of this research can be said that the implementation is done by IILSA of Pasuruan city has been good although there are a few things that need to be improved related to the internet connection is still an obstacle in the implementation of the operational in the delivery service for SIUP and also the lack of facilities and infrastructure available. Keywords: IILSA of Pasuruan City, Licensing Service, SIUP (Business License, Improve Service, The Implementation.

  1. Comparative Study on Innovation Incentives for Commercial Open Source Software under Different Licenses

    OpenAIRE

    Mingqing Xing

    2013-01-01

    This study compares technological innovation incentives for commercial open source software under two typical licenses (the GNU General Public License and the Berkeley Software Distribution License, i.e., GPL and BSD). In the case of private optimum, the incentive towards software features (resp. usability) innovation is always higher (resp. lower) under BSD than under GPL. Contrast to the private optimum, the social planner expects more investment in software feature under both BSD and GPL, ...

  2. Study and achievement of a digital-analog-divider

    International Nuclear Information System (INIS)

    This apparatus is designed to give directly, in digital form, the value of the ratio Vt1/V2 two analog voltages. It consists essentially of an analog-digital coder operating by successive weighing; the comparison voltage is made proportional to the divider V2 in the coder. The input dynamics are such that the voltages Vi and V2 are all in the range -50 mV to -5 V. Each of the circuits has an input impedance of about 10 KΩ. As for the quotient, it is a binary number given in series and parallel form; it is made up of 8 bits, this giving a change of 1/16 to 16 per jump of 1/16 in the zone where the accuracy is highest (V2 ≥ 800 mV). The time required for a division is, at best, 15 μsec. During the time of calculation, the voltages V1 and V2 should not vary by more than 1 per cent and 0.5 per cent respectively. The theory of the system and the investigation of a synoptic diagram, the study of the circuits and the actual construction are presented. (author)

  3. Potential threat to licensed nuclear activities from insiders (insider study). Technical report

    International Nuclear Information System (INIS)

    The Insider Study was undertaken by NRC staff at the request of the Commission. Its objectives were to: (1) determine the characteristics of potential insider adversaries to licensed nuclear activities; (2) examine security system vulnerabilities to insider adversaries; and (3) assess the effectiveness of techniques used to detect or prevent insider malevolence. The study analyzes insider characteristics as revealed in incidents of theft or sabotage that occurred in the nuclear industry, analogous industries, government agencies, and the military. Adversary characteristics are grouped into four categories: position-related, behavioral, resource and operational. It also analyzes (1) the five security vulnerabilities that most frequently accounted for the success of the insider crimes in the data base; (2) the 11 means by which insider crimes were most often detected; and (3) four major and six lesser methods aimed at preventing insider malevolence. In addition to case history information, the study contains data derived from non-NRC studies and from interviews with over 100 security experts in industry, government (federal and state), and law enforcement

  4. TV Analog Station Transmitters

    Data.gov (United States)

    Department of Homeland Security — This file is an extract from the Consolidated Database System (CDBS) licensed by the Media Bureau. It consists of Analog Television Stations (see Rule Part47 CFR...

  5. Rheology of lava flows on Mercury: An analog experimental study

    Science.gov (United States)

    Sehlke, A.; Whittington, A. G.

    2015-11-01

    We experimentally determined the rheological evolution of three basaltic analog compositions appropriate to Mercury's surface, during cooling, and crystallization. Investigated compositions are an enstatite basalt, and two magnesian basalts representing the compositional end-members of the northern volcanic plains with 0.19 wt % (NVP) and 6.26 wt % Na2O (NVP-Na). The viscosity-strain rate dependence of lava was quantified using concentric cylinder viscometry. We measured the viscosities of the crystal-free liquids from 1600°C down to the first detection of crystals. Liquidus temperatures of the three compositions studied are around 1360°C, and all three compositions are more viscous than Hawaiian basalt at the same temperature. The onset of pseudoplastic behavior was observed at crystal fractions ~0.05 to 0.10, which is consistent with previous studies on mafic lavas. We show that all lavas develop detectable yield strengths at crystal fractions around 0.20, beyond which the two-phase suspensions are better described as Herschel-Bulkley fluids. By analogy with the viscosity-strain rate conditions at which the pahoehoe to `a`a transition occurs in Kilauea basalt, this transition is predicted to occur at ~1260 ± 10°C for the enstatite basalt, at ~1285 ± 20°C for the NVP, and at ~1240 ± 40°C for the NVP-Na lavas. Our results indicate that Mercury lavas are broadly similar to terrestrial ones, which suggests that the extensive smooth lava plains of Mercury could be due to large effusion rates (flood basalts) and not to unusually fluid lavas.

  6. Feasibility Study of a Lunar Analog Bed Rest Model

    Science.gov (United States)

    Cromwell, Ronita L.; Platts, Steven H.; Yarbough, Patrice; Buccello-Stout, Regina

    2010-01-01

    The purpose of this study was to determine the feasibility of using a 9.5deg head-up tilt bed rest model to simulate the effects of the 1/6 g load to the human body that exists on the lunar surface. The lunar analog bed rest model utilized a modified hospital bed. The modifications included mounting the mattress on a sled that rolled on bearings to provide freedom of movement. The weight of the sled was off-loaded using a counterweight system to insure that 1/6 body weight was applied along the long axis (z-axis) of the body. Force was verified through use of a force plate mounted at the foot of the bed. A seating assembly was added to the bed to permit periods of sitting. Subjects alternated between standing and sitting positions throughout the day. A total of 35% of the day was spent in the standing position and 65% was spent sitting. In an effort to achieve physiologic fluid shifts expected for a 1/6 G environment, subjects wore compression stockings and performed unloaded foot and ankle exercises. Eight subjects (3 females and 5 males) participated in this study. Subjects spent 13 days in the pre-bed rest phase, 6 days in bed rest and 3 days post bed rest. Subjects consumed a standardized diet throughout the study. To determine feasibility, measures of subject comfort, force and plasma volume were collected. Subject comfort was assessed using a Likert scale. Subjects were asked to assess level of comfort (0-100) for 11 body regions and provide an overall rating. Results indicated minimal to no discomfort as most subjects reported scores of zero. Force measures were performed for each standing position and were validated against subject s calculated 1/6 body weight (r(sup 2) = 0.993). The carbon monoxide rebreathing technique was used to assess plasma volume during pre-bed rest and on the last day of bed rest. Plasma volume results indicated a significant decrease (p = 0.001) from pre to post bed rest values. Subjects lost on average 8.3% (sd = 6.1%) during the

  7. Evaluation environment for digital and analog pathology: a platform for validation studies.

    Science.gov (United States)

    Gallas, Brandon D; Gavrielides, Marios A; Conway, Catherine M; Ivansky, Adam; Keay, Tyler C; Cheng, Wei-Chung; Hipp, Jason; Hewitt, Stephen M

    2014-10-01

    We present a platform for designing and executing studies that compare pathologists interpreting histopathology of whole slide images (WSIs) on a computer display to pathologists interpreting glass slides on an optical microscope. eeDAP is an evaluation environment for digital and analog pathology. The key element in eeDAP is the registration of the WSI to the glass slide. Registration is accomplished through computer control of the microscope stage and a camera mounted on the microscope that acquires real-time images of the microscope field of view (FOV). Registration allows for the evaluation of the same regions of interest (ROIs) in both domains. This can reduce or eliminate disagreements that arise from pathologists interpreting different areas and focuses on the comparison of image quality. We reduced the pathologist interpretation area from an entire glass slide (10 to [Formula: see text]) to small ROIs ([Formula: see text]). We also made possible the evaluation of individual cells. We summarize eeDAP's software and hardware and provide calculations and corresponding images of the microscope FOV and the ROIs extracted from the WSIs. The eeDAP software can be downloaded from the Google code website (project: eeDAP) as a MATLAB source or as a precompiled stand-alone license-free application. PMID:26158076

  8. Building licenses for wind turbines. Preliminary directives and case studies

    Energy Technology Data Exchange (ETDEWEB)

    1982-12-01

    Directives for construction permits and operating licenses. Possible effects on the environment (nuissance, bird killing, noise and vibration, poor reception of radio and TV signals) are discussed briefly. Guidelines related to safety, construction and urban planning are dealt with and conditions for the erection of wind turbines are given. Legal aspects are surveyed.

  9. An In Situ Study of Analogical Reasoning in Novice and Experienced Design Engineers

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Christensen, B T

    2009-01-01

    This paper describes a study to understand the use of analogies by design engineers with different levels of experience in an adaptive design domain. Protocol analyses of 12 design engineers have been analyzed to understand the functions and reasoning of the analogies. The protocols are real......-world data from the aerospace industry. The findings indicate a significant difference in both the use of analogies by novices and experienced designers and the reasoning from the analogies. Novices were found to predominantly transfer information related to the geometric properties without explicit...... reference to relevant design issues or to the appropriateness of applying the analogy, whereas experienced designers tended to use analogies for problem solving and problem identification. Experienced designers were found to use the analogy to reason about the function of a component and the predicted...

  10. Comparative Study on Innovation Incentives for Commercial Open Source Software under Different Licenses

    Directory of Open Access Journals (Sweden)

    Mingqing Xing

    2013-02-01

    Full Text Available This study compares technological innovation incentives for commercial open source software under two typical licenses (the GNU General Public License and the Berkeley Software Distribution License, i.e., GPL and BSD. In the case of private optimum, the incentive towards software features (resp. usability innovation is always higher (resp. lower under BSD than under GPL. Contrast to the private optimum, the social planner expects more investment in software feature under both BSD and GPL, but less (resp. equivalent investment in software usability under BSD (resp. GPL.

  11. High accuracy computation with linear analog optical systems: a critical study

    OpenAIRE

    Psaltis, Demetri; Athale, Ravindra A.

    1986-01-01

    High accuracy optical processors based on the algorithm of digital multiplication by analog convolution (DMAC) are studied for ultimate performance limitations. Variations of optical processors that perform high accuracy vector-vector inner products are studied in abstract and with specific examples. It is concluded that the use of linear analog optical processors in performing digital computations with DMAC leads to impractical requirements for the accuracy of analog optical systems and the ...

  12. Dopamine D-2 activity of R-(-)-apomorphine and selected analogs : a microdialysis study

    NARCIS (Netherlands)

    Rodenhuis, N; Dijkstra, D; Vermeulen, ES; Timmerman, W; Wikstrom, HV

    2000-01-01

    In the present study, R-(-)-apomorphine and three of its analogs were studied for their potency in decreasing the release of dopamine in the striatum after subcutaneous administration and for their oral bioavailability using the microdialysis technique in freely moving rats. The analogs R-(-)-N-n-pr

  13. Embedding Analogical Reasoning into 5E Learning Model: A Study of the Solar System

    Science.gov (United States)

    Devecioglu-Kaymakci, Yasemin

    2016-01-01

    The purpose of this study was to investigate how the 5E learning model affects learning about the Solar System when an analogical model is utilized in teaching. The data were gathered in an urban middle school 7th grade science course while teaching relevant astronomy topics. The analogical model developed by the researchers was administered to 20…

  14. Analogical scaffolding and the learning of abstract ideas in physics: Empirical studies

    Directory of Open Access Journals (Sweden)

    Noah D. Finkelstein

    2007-09-01

    Full Text Available Previously, we proposed a model of student reasoning which combines the roles of representation, analogy, and layering of meaning—analogical scaffolding [Podolefsky and Finkelstein, Phys. Rev. ST Phys. Educ. Res. 3, 010109 (2007]. The present empirical studies build on this model to examine its utility and demonstrate the vital intertwining of representation, analogy, and conceptual learning in physics. In two studies of student reasoning using analogy, we show that representations couple to students’ existing prior knowledge and also lead to the dynamic formation of new knowledge. Students presented with abstract, concrete, or blended (both abstract and concrete representations produced markedly different response patterns. In the first study, using analogies to scaffold understanding of electromagnetic (EM waves, students in the blend group were more likely to reason productively about EM waves than students in the abstract group by as much as a factor of 3 (73% vs 24% correct, p=0.002 . In the second study, examining representation use within one domain (sound waves, the blend group was more likely to reason productively about sound waves than the abstract group by as much as a factor of 2 (48% vs 23% correct, p=0.002 . Using the analogical scaffolding model we examine when and why students succeed and fail to use analogies and interpret representations appropriately.

  15. Contractual Solutions in Electronic Publishing Industry: A Comparative study of License Agreements

    Directory of Open Access Journals (Sweden)

    K.T. Anuradha

    2005-10-01

    Full Text Available Information Technology (IT revolution has brought global change and has impact on electronic publishing industry also. In the digital and networked environment, publishers are concerned about protecting their products from illegal use. Copyright has been proclaimed as an important weapon by the publishers to safeguard their products. In view of the increasing importance that is gained by contract law in electronic publishing, more and more libraries are engaged in signing License Agreements for getting access to all types of electronic information products. It has become imperative on the part of librarians to have knowledge of License agreements and their clauses. The body of the license agreements differs from publisher to publisher and is product dependent too. Since there is a difference between the license agreements of societal publishers and commercial publishers, an attempt is made here to carry out a comparative study of the clauses of the license agreements among commercial publishers at the first level and societal publishers at the second level. It is observed that the licensors’ rights are well protected compared to that of licensees’ rights.

  16. Atomistic study of macroscopic analogs to short-chain molecules

    Science.gov (United States)

    Welch, Kyle J.; Kilmer, Clayton S. G.; Corwin, Eric I.

    2015-02-01

    We use a bath of chaotic surface waves in water to mechanically and macroscopically mimic the thermal behavior of a short articulated chain with only nearest-neighbor interactions. The chaotic waves provide isotropic and random agitation to which a temperature can be ascribed, allowing the chain to passively explore its degrees of freedom in analogy to thermal motion. We track the chain in real time and infer end-to-end potentials using Boltzmann statistics. We extrapolate our results, by using Monte Carlo simulations of self-avoiding polymers, to lengths not accessible in our system. In the long-chain limit we demonstrate universal scaling of the statistical parameters of all chains in agreement with well-known predictions for self-avoiding walks. However, we find that the behavior of chains below a characteristic length scale fundamentally differs. We find that short chains have much greater compressional stiffness than would be expected. However, chains rapidly soften as length increases to meet with expected scalings.

  17. Licensing experiences of safety critical software systems in nuclear applications a case study

    International Nuclear Information System (INIS)

    This paper summarizes results of reviews on the safety, critical software performed during the licensing process for the new Wolsung units. Each of these CANDU-type nuclear power plants has two micro-computerized shutdown systems. The SDS No. 1 program is graphically programmed in such a manner that its development process does not essentially differ from the design process of the conventional analog counterpart. This approach is understandable even to a reviewer in the regulatory agency without additional training in software engineering. The confidence in the reliability of this system is strengthened by the reverse verification and increased by extensive testing such as the reliability test. Concerning SDS No. 2, the development process is significantly influenced by the software cost reduction project of the U.S. naval research laboratory, and is, as a whole, clear and well structured except for the modules related to the operation of the computer itself. These modules contain some algorithms which are not easy to understand. However, their correctness verifications are requested by the reviewer and supplemented by the developer. After the clarification of these issues, there are no substantial problems that constitute a significant impediment to licensing. 32 refs., 7 figs

  18. The Cigar Lake analog study: An international R ampersand D project

    International Nuclear Information System (INIS)

    This paper provides background information and summarizes the results of AECL's analog study on the Cigar Lake uranium deposit. This R ampersand D project includes national and international cooperation with many organizations directly or indirectly involved in nuclear waste management research. The emphasis is on the analog aspects of this deposit and the implications of modelling activities related to the environmental and safety assessment of the Canadian disposal concept for nuclear fuel waste

  19. Quantitative analysis of carbonate sandbodies : outcrop analog study from an epicontinental basin (Triassic Germany)

    OpenAIRE

    Braun, Sascha

    2003-01-01

    Scope This outcrop analog study aims to provide quantitative data concerning dimensions, spatial distribution, internal structure and poro-perm characteristics of carbonate shoal bodies on a carbonate ramp system. Shelly-oolitic carbonate bodies of the SW-German Upper Muschelkalk represent excellent outcrop analogs for hydrocarbon reservoirs in epeiric carbonate systems of the Middle East (e.g. Khuff, Hanifa, Arab). Methods & data Sampling of a few thousand polished slabs and detail...

  20. General and specialized brain correlates for analogical reasoning: A meta-analysis of functional imaging studies.

    Science.gov (United States)

    Hobeika, Lucie; Diard-Detoeuf, Capucine; Garcin, Béatrice; Levy, Richard; Volle, Emmanuelle

    2016-05-01

    Reasoning by analogy allows us to link distinct domains of knowledge and to transfer solutions from one domain to another. Analogical reasoning has been studied using various tasks that have generally required the consideration of the relationships between objects and their integration to infer an analogy schema. However, these tasks varied in terms of the level and the nature of the relationships to consider (e.g., semantic, visuospatial). The aim of this study was to identify the cerebral network involved in analogical reasoning and its specialization based on the domains of information and task specificity. We conducted a coordinate-based meta-analysis of 27 experiments that used analogical reasoning tasks. The left rostrolateral prefrontal cortex was one of the regions most consistently activated across the studies. A comparison between semantic and visuospatial analogy tasks showed both domain-oriented regions in the inferior and middle frontal gyri and a domain-general region, the left rostrolateral prefrontal cortex, which was specialized for analogy tasks. A comparison of visuospatial analogy to matrix problem tasks revealed that these two relational reasoning tasks engage, at least in part, distinct right and left cerebral networks, particularly separate areas within the left rostrolateral prefrontal cortex. These findings highlight several cognitive and cerebral differences between relational reasoning tasks that can allow us to make predictions about the respective roles of distinct brain regions or networks. These results also provide new, testable anatomical hypotheses about reasoning disorders that are induced by brain damage. Hum Brain Mapp 37:1953-1969, 2016. © 2016 Wiley Periodicals, Inc. PMID:27012301

  1. Lessons from Natural Analog Studies for Geologic Disposal of High-Level Nuclear Waste (Invited)

    Science.gov (United States)

    Murphy, W. M.

    2009-12-01

    For over fifty years natural analog studies have provided lessons addressing scientific, technical, and social problems concerning geologic disposal of high-level nuclear waste. Idealized concepts for permanent disposal environments evolved from an understanding of the geological, geochemical and hydrological characteristics of analogous rocks including natural salt deposits (as advocated by the US National Academy of Sciences in 1957), ancient cratonic rocks (as investigated at Lac du Bonnet, Canada, Aspö, Sweden, and Vienne, France), and marine sedimentary rock formations (as studied at Mol, Belgium, and Bure, France). Additional multidisciplinary studies have been conducted at natural sites that bear characteristics analogous to potential repository systems, notably at natural uranium (and thorium) deposits including Poços de Caldas, Brazil, Alligator Rivers, Australia, Peña Blanca, Mexico, and Oklo, Gabon. Researchers of natural analogs for geologic disposal have addressed technical uncertainties regarding processes that have transpired over large time and space scales, which are generally inaccessible to laboratory studies. Principal questions for nuclear waste disposal include the geochemical stability and alteration rates of radionuclide bearing minerals and the mechanisms and rates of transport of radionuclides in groundwater. In their most direct applications, natural analogs studies have been devoted to testing specific models for repository performance and the experimental data that support those models. Parameters used in predictive performance assessment modeling have been compared to natural system data, including mineral solubilities, sorption coefficients, diffusion rates, and colloid transport properties. For example, the rate of uraninite oxidation and the natural paragenesis of uranium mineral alteration at Peña Blanca have been compared favorably to results of experimental studies of spent fuel alteration related to the proposed repository

  2. Barrier analogs: Long-term performance issues, preliminary studies, and recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Waugh, W.J. [Rust Geotech, Inc., Grand Junction, CO (United States). Environmental Sciences Lab.; Chatters, J.C.; Last, G.V.; Bjornstad, B.N.; Link, S.O. [Pacific Northwest Lab., Richland, WA (United States); Hunter, C.R. [Cascade Earth Sciences, La Grande, OR (United States)

    1994-02-01

    The US Department of Energy`s Hanford Protective Barrier Development Program is funding studies of natural analogs of the long-term performance of waste site covers. Natural-analog studies examine past environments as evidence for projecting the future performance of engineered structures. The information generated by analog studies is needed to (1) evaluate the designs and results of short term experiments and demonstrations, (2) formulate performance-modeling problems that bound expected changes in waste site environments, and (3) understand emergent system attributes that cannot be evaluated with short-term experiments or computer models. Waste site covers will be part of dynamic environmental systems with attributes that transcend the traits of engineered components. This report discusses results of the previously unreported preliminary studies conducted in 1983 and 1984. These results indicate that analogs could play an important role in predicting the long-term behavior of engineered waste covers. Layered exposures of glacial-flood-deposited gravels mantled with silt or sand that resemble contemporary barrier designs were examined. Bergmounds, another anomaly left by cataclysmic glacial floods, were also examined as analogs of surface gravel.

  3. Study of a conceptual nuclear energy center at Green River, Utah: institutional and licensing issues

    International Nuclear Information System (INIS)

    This document constitutes a segment of a feasibility study investigating the ramification of construcing a nuclear energy center in an arid western region. In this phase of the study, the institutional and licensing issues impacting a NEC were analyzed. The most prominent issue facing such a concept is the ownership form of NEC. In addition, legislation and regulation also have a substantial impact regardless of the ownership format

  4. Contribution of studies for environmental licensing to the knowledge of Santa Catarina avifauna in southern Brazil

    OpenAIRE

    Marcos Antônio Guimarães Azevedo

    2006-01-01

    The knowledge generated by studies for environmental licensing, even with reduced field samplings, can contribute to the recording of species of avifauna or actually extends the distribution in places of low knowledge. This study presents data obtained from preliminary reports of impact where the avifauna in seven projects in different ecosystems of Santa Catarina state was diagnosed between January 2001 and January 2004. Sightings had occurred, mainly, by visual or auditory contacts, using b...

  5. Halogenated cocaine analogs for PET and SPECT studies

    International Nuclear Information System (INIS)

    The authors report here the synthesis of fluorine and iodine phenyl substituted derivatives of [N-11C-methyl]cocaine in order to examine the sensitivity of the parent molecule to structural modification and to explore the possibility of labelling this molecule with the longer lived radionuclides fluorine-18 and iodine-123 for PET and SPECT studies. Tissue distribution studies were conducted in baboons with these analogues

  6. Use of Analogies in the Study of Diffusion

    Science.gov (United States)

    Letic, Milorad

    2014-01-01

    Emergent processes, such as diffusion, are considered more difficult to understand than direct processes. In physiology, most processes are presented as direct processes, so emergent processes, when encountered, are even more difficult to understand. It has been suggested that, when studying diffusion, misconceptions about random processes are the…

  7. Repository program licensing approach

    International Nuclear Information System (INIS)

    Yucca Mountain, Nevada is currently being studied by the US Department of Energy (DOE) as a potential site for a mined geologic repository for high-level nuclear waste. DOE has the responsibility to determine the suitability of the site and to develop a license application (LA) for authorization to construct the potential repository. If the site is suitable, the license application would be submitted to the US Nuclear Regulatory Commission (NRC). The repository program licensing approach is focused on the timely acquisition of information needed in licensing and the resolution of potential licensing issues with the NRC staff. Licensing involves an iterative process requiring refinements as data are acquired, analyzed, and evaluated. The repository licensing approach presented in this paper ensures that the information is available when needed to facilitate the licensing process. Identifying the information needed to evaluate compliance with the performance objectives in 10 CFR 60, monitoring the acquisition of such information, and developing a successful license application are integral elements of DOE's repository program licensing approach. Activities to characterize the site are being systematically conducted as planned in the Site Characterization Plan (SCP). In addition, DOE is implementing the issue resolution initiative, the license application annotated outline (LAAO) process, and interim licensability evaluations to update the early planning in the SCP and to focus site characterization, design, and performance assessment activities on the acquisition of information needed for a site suitability determination and licensing. Collectively, the issue resolution initiative, LAAO process, and interim licensability evaluations are key elements of a transition to the iterative process to answer the question: open-quotes When do we have enough data to support licensing?close quotes

  8. Anandamide and analogous endocannabinoids: a lipid self-assembly study

    Energy Technology Data Exchange (ETDEWEB)

    Sagnella, Sharon M.; Conn, Charlotte E.; Krodkiewska, Irena; Mulet, Xavier; Drummond, Calum J.

    2014-09-24

    Anandamide, the endogenous agonist of the cannabinoid receptors, has been widely studied for its interesting biological and medicinal properties and is recognized as a highly significant lipid signaling molecule within the nervous system. Few studies have, however, examined the effect of the physical conformation of anandamide on its function. The study presented herein has focused on characterizing the self-assembly behaviour of anandamide and four other endocannabinoid analogues of anandamide, viz., 2-arachidonyl glycerol, arachidonyl dopamine, 2-arachidonyl glycerol ether (noladin ether), and o-arachidonyl ethanolamide (virodhamine). Molecular modeling of the five endocannabinoid lipids indicates that the highly unsaturated arachidonyl chain has a preference for a U or J shaped conformation. Thermal phase studies of the neat amphiphiles showed that a glass transition was observed for all of the endocannabinoids at {approx} -110 C with the exception of anandamide, with a second glass transition occurring for 2-arachidonyl glycerol, 2-arachidonyl glycerol ether, and virodhamine (-86 C, -95 C, -46 C respectively). Both anandamide and arachidonyl dopamine displayed a crystal-isotropic melting point (-4.8 and -20.4 C respectively), while a liquid crystal-isotropic melting transition was seen for 2-arachidonyl glycerol (-40.7 C) and 2-arachidonyl glycerol ether (-71.2 C). No additional transitions were observed for virodhamine. Small angle X-ray scattering and cross polarized optical microscopy studies as a function of temperature indicated that in the presence of excess water, both 2-arachidonyl glycerol and anandamide form co-existing Q{sub II}{sup G} (gyroid) and Q{sub II}{sup D} (diamond) bicontinuous cubic phases from 0 C to 20 C, which are kinetically stable over a period of weeks but may not represent true thermodynamic equilibrium. Similarly, 2-arachidonyl glycerol ether acquired an inverse hexagonal (HII) phase in excess water from 0 C to 40 C, while

  9. A Study on the Standard of Optician National Licensing Examination by Job Analysis

    OpenAIRE

    Won Jin Lee; Chan Hee Won; Ki Choong Mah; Duk Yong Sung; Sung Soo Kang; Do Jin Youk; Hae Jong Park

    2004-01-01

    This study shows the optician's job analysis, some questionaire and their analysis. Job description drafed, the standard of questionaire was fixed. Job description is establised on the results of the job analysis by DACUM(Developing A Curriculum Method). The job description formed above 2.15 referred to the results of survey of the importance and perfomance frequency of the job. These elements made a draft of drawing up standard of the Optician National Licensing Examination by Job Analy...

  10. A study of the validity of the Korean Nurses' Licensing Examination

    OpenAIRE

    Hyang Yeon Lee; Cho Ja Kim; Sook Ja Lee; Ho Ran Park; In Sook Lee; Hoo Ja Kim; Young Mi Park

    2005-01-01

    This study tested the validity of subjects in the Korean Nurses' Licensing Examination (KNLE). To determine the validity of test items in the KNLE, the items testing each subject in the examination and all of the test items were compared. The homogeneity and proper degree of conceptual diversity of the items in the examination were tested by comparing the frameworks of the test items in the National Council Licensure Examination for Registered Nurses (NCLEX-RN) and the KNLE. The validity...

  11. A comparative study on fluorescent cholesterol analogs as versatile cellular reporters.

    Science.gov (United States)

    Sezgin, Erdinc; Can, Fatma Betul; Schneider, Falk; Clausen, Mathias P; Galiani, Silvia; Stanly, Tess A; Waithe, Dominic; Colaco, Alexandria; Honigmann, Alf; Wüstner, Daniel; Platt, Frances; Eggeling, Christian

    2016-02-01

    Cholesterol (Chol) is a crucial component of cellular membranes, but knowledge of its intracellular dynamics is scarce. Thus, it is of utmost interest to develop tools for visualization of Chol organization and dynamics in cells and tissues. For this purpose, many studies make use of fluorescently labeled Chol analogs. Unfortunately, the introduction of the label may influence the characteristics of the analog, such as its localization, interaction, and trafficking in cells; hence, it is important to get knowledge of such bias. In this report, we compared different fluorescent lipid analogs for their performance in cellular assays: 1) plasma membrane incorporation, specifically the preference for more ordered membrane environments in phase-separated giant unilamellar vesicles and giant plasma membrane vesicles; 2) cellular trafficking, specifically subcellular localization in Niemann-Pick type C disease cells; and 3) applicability in fluorescence correlation spectroscopy (FCS)-based and super-resolution stimulated emission depletion-FCS-based measurements of membrane diffusion dynamics. The analogs exhibited strong differences, with some indicating positive performance in the membrane-based experiments and others in the intracellular trafficking assay. However, none showed positive performance in all assays. Our results constitute a concise guide for the careful use of fluorescent Chol analogs in visualizing cellular Chol dynamics. PMID:26701325

  12. A comparative study on fluorescent cholesterol analogs as versatile cellular reporters

    DEFF Research Database (Denmark)

    Sezgin, Erdinc; Betul Can, Fatma; Schneider, Falk; Clausen, Mathias P.; Galiani, Silvia; Stanly, Tess A.; Waithe, Dominic; Colaco, Alexandria; Honigmann, Alf; Wüstner, Daniel; Platt, Frances; Eggeling, Christian

    2016-01-01

    performance in cellular assays: 1) plasma membrane incorporation, specifically the preference for more ordered membrane environments in phase separated giant unilamellar vesicles (GUVs) and giant plasma membrane vesicles (GPMVs); 2) cellular trafficking, specifically subcellular localization in Niemann-Pick C......Cholesterol is a crucial component of cellular membranes, but knowledge of its intracellular dynamics is scarce. Thus, it is of utmost interest to develop tools for visualization of cholesterol organization and dynamics in cells and tissues. For this purpose, many studies make use of fluorescently......-labeled cholesterol analogs. Unfortunately, the introduction of the label may influence the characteristics of the analog, such as its localization, interaction and trafficking in cells, hence it is important to get knowledge of such bias. In this report, we compared different fluorescent lipid analogs for their...

  13. A comparative study on fluorescent cholesterol analogs as versatile cellular reporters

    DEFF Research Database (Denmark)

    Sezgin, Erdinc; Betul Can, Fatma; Schneider, Falk;

    2016-01-01

    Cholesterol is a crucial component of cellular membranes, but knowledge of its intracellular dynamics is scarce. Thus, it is of utmost interest to develop tools for visualization of cholesterol organization and dynamics in cells and tissues. For this purpose, many studies make use of fluorescently......-labeled cholesterol analogs. Unfortunately, the introduction of the label may influence the characteristics of the analog, such as its localization, interaction and trafficking in cells, hence it is important to get knowledge of such bias. In this report, we compared different fluorescent lipid analogs for their...... performance in cellular assays: 1) plasma membrane incorporation, specifically the preference for more ordered membrane environments in phase separated giant unilamellar vesicles (GUVs) and giant plasma membrane vesicles (GPMVs); 2) cellular trafficking, specifically subcellular localization in Niemann-Pick C...

  14. X-ray Structural Studies of Prussian Blue Analog Heterostructures on Poly(ethylene terephthalate) Supports

    Energy Technology Data Exchange (ETDEWEB)

    Pajerowski, Daniel M. [NIST Center for Neutron Research, Gaithersburg, MD (United States); Zakrzewski, Brian M. [NIST Center for Neutron Research, Gaithersburg, MD (United States); Ravel, Bruce [Materials Science and Engineering Lab., Gaithersburg, MD (United States)

    2012-10-27

    We have used X-rays to study the structure of photomagnetic, heterostructured films of nickel hexacyanochromate and cobalt hexacyanoferrate Prussian blue analogs on poly(ethylene terephthalate) solid supports. The nature of the interface between supporting polymer and Prussian blue analog is investigated and either positive or negative ions will bind to the surface depending upon pre-treatment. Furthermore, for heterostructured films fabricated using layers of a few hundred nanometers, each layer retains a crystal structure similar to that in the homogeneous phase, while heterostructured films that layer nanometer scale layers result in a solid solution of the two compounds that may have bond deformation. These sequential adsorption films are polycrystalline.

  15. Study of $^{13}$Be through isobaric analog resonances in the Maya active target

    CERN Multimedia

    Riisager, K; Orr, N A; Jonson, B N G; Raabe, R; Fynbo, H O U; Nilsson, T

    We propose to perform an experiment with a $^{12}$Be beam and the Maya active target. We intend to study the ground state of $^{13}$Be through the population of its isobaric analog resonance in $^{13}$B. The resonance will be identified detecting its proton- and neutron-decay channels.

  16. ITER licensing

    International Nuclear Information System (INIS)

    ITER was fortunate to have four countries interested in ITER siting to the point where licensing discussions were initiated. This experience uncovered the challenges of licensing a first of a kind, fusion machine under different licensing regimes and helped prepare the way for the site specific licensing process. These initial steps in licensing ITER have allowed for refining the safety case and provide confidence that the design and safety approach will be licensable. With site-specific licensing underway, the necessary regulatory submissions have been defined and are well on the way to being completed. Of course, there is still work to be done and details to be sorted out. However, the informal international discussions to bring both the proponent and regulatory authority up to a common level of understanding have laid the foundation for a licensing process that should proceed smoothly. This paper provides observations from the perspective of the International Team. (author)

  17. Final report of the AECL/SKB Cigar Lake analog study. AECL research No. AECL-10851

    Energy Technology Data Exchange (ETDEWEB)

    Cramer, J.J.; Smellie, J.A.T. (eds.)

    1994-07-15

    AECL has conducted natural analog studies on the Cigar Lake uranium deposit in northern Saskatchewan since 1984 as part of the Canadian Nuclear Fuel Waste Management Program. This report provides background information and summarizes the results of the study, emphasizing the analog aspects and the implications of modelling activities related to the performance assessment of disposal concepts for nuclear fuel wastes developed in both Canada and Sweden. The study was undertaken to obtain an understanding of the process involved in, and the effects of, steady-state water-rock interaction and trace-element migration in and around the deposit, including paleo-migration processes since the deposit was formed. To achieve these objectives, databases and models were produced to evaluate the equilibrium thermodynamic codes and databases; the role of colloids, organics, and microbes in transport processes for radionuclides; and the stability of UO2 and the influence of radiolysis on UO2 dissolution and radionuclide migration.

  18. Assessing the "need to negotiate" in FERC licensing consultations: a study of two hydropower projects

    Science.gov (United States)

    Coughlan, Beth A. K.; Burkardt, Nina; Fulton, David

    1993-01-01

    We investigated the “need to negotiate” in a comparative case study of multi-agency negotiations in the FERC licensing process. Researchers interviewed participants in two cases involving environmental consultations and asked about parties' level of need to negotiate throughout the process. Participants identified a need to negotiate, and when this need was strongly felt, there was an increased opportunity for an agreement to be reached. An intense need to negotiate by all parties is not a prerequisite to successful agreements. When key participants have a strong need to negotiate, they can instigate negotiations and encourage the involvement of other parties.

  19. A Study on the Standard of Optician National Licensing Examination by Job Analysis

    Directory of Open Access Journals (Sweden)

    Won Jin Lee

    2004-01-01

    Full Text Available This study shows the optician's job analysis, some questionaire and their analysis. Job description drafed, the standard of questionaire was fixed. Job description is establised on the results of the job analysis by DACUM(Developing A Curriculum Method. The job description formed above 2.15 referred to the results of survey of the importance and perfomance frequency of the job. These elements made a draft of drawing up standard of the Optician National Licensing Examination by Job Analysis.

  20. Detecting Malingering in Compensated Low Back Pain Patients: An Analog Study

    OpenAIRE

    Grewe, Jennifer R.

    2010-01-01

    Given the prevalence and cost of low back pain, particularly among workers' compensation patients, it is advantageous to understand how various psychological constructs may be related to prolonged disability and failure to return to work. Malingering is a psychological construct that is clearly relevant for worker compensation populations and is a construct that is well suited for experimental control within an analog study. Malingering is the intentional exaggeration of physical or psycholog...

  1. Evaluation environment for digital and analog pathology: a platform for validation studies

    OpenAIRE

    Gallas, Brandon D.; Gavrielides, Marios A; Conway, Catherine M; Ivansky, Adam; Keay, Tyler C.; Cheng, Wei-Chung; Hipp, Jason; Hewitt, Stephen M

    2014-01-01

    Abstract. We present a platform for designing and executing studies that compare pathologists interpreting histopathology of whole slide images (WSIs) on a computer display to pathologists interpreting glass slides on an optical microscope. eeDAP is an evaluation environment for digital and analog pathology. The key element in eeDAP is the registration of the WSI to the glass slide. Registration is accomplished through computer control of the microscope stage and a camera mounted on the micro...

  2. U-Series Transport Studies at the Pena Blanca, Mexico Natural Analog Site

    International Nuclear Information System (INIS)

    Natural analogs provide a line of evidence that supports the understanding of how natural and engineered processes would occur over long time frames and large spatial scales at a potential nuclear waste repository at Yucca Mountain, Nevada. Studies of U-series disequilibria within and around uranium deposits can provide valuable information on the timing of actinide mobility and hence the stability of a potential repository over geologic time scales. The Nopal I uranium deposit at Pena Blanca, Mexico, is situated in unsaturated tuff that is similar in composition to the Topopah Spring Tuff of Yucca Mountain and closely matches other evaluation criteria for suitable natural analogs. By modeling the observed radioactive isotope disequilibria at Nopal I, we can estimate the rates of sorption-desorption and dissolution-precipitation of the radionuclides over time. Such information is vital to the testing or validation of performance assessment models for geologic nuclear waste disposal

  3. U-Series Transport Studies at the Pena Blanca, Mexico Natural Analog Site

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Simmons; M. T. Murrell

    2001-05-31

    Natural analogs provide a line of evidence that supports the understanding of how natural and engineered processes would occur over long time frames and large spatial scales at a potential nuclear waste repository at Yucca Mountain, Nevada. Studies of U-series disequilibria within and around uranium deposits can provide valuable information on the timing of actinide mobility and hence the stability of a potential repository over geologic time scales. The Nopal I uranium deposit at Pena Blanca, Mexico, is situated in unsaturated tuff that is similar in composition to the Topopah Spring Tuff of Yucca Mountain and closely matches other evaluation criteria for suitable natural analogs. By modeling the observed radioactive isotope disequilibria at Nopal I, we can estimate the rates of sorption-desorption and dissolution-precipitation of the radionuclides over time. Such information is vital to the testing or validation of performance assessment models for geologic nuclear waste disposal.

  4. Use of natural analog and modeling studies to constrain the effects of magmatic activity on long-term geologic repositories

    International Nuclear Information System (INIS)

    Examples of the application of natural-analog studies to the estimation of the consequences of a volcanic eruption penetrating a radioactive waste repository are given, including the criteria for analog selection and new data from ongoing studies. Examples of early modeling results focusing on the spatial and temporal scale of subsurface processes are also provided. All of these examples are taken from studies of the potential Yucca Mountain repository, Nevada, but similar approaches could be applied in other areas. In addition, studies of subsurface processes initiated by magmatic events serve as useful analogs for repository thermal loading studies

  5. Complexation of Iron by Dopamine Analogs; A Spectrophotometric and Potentiometric Study

    OpenAIRE

    *T. Fiaz; N. Fatima; S. Z. A. Zaidi

    2013-01-01

    The chelation of Bio-essential metal, Iron, with dopamine analogs was studied at 30±2°C. Fe2+ formed intense color complex with these molecules with an absorbance maxima in visible region. A distinct peak of Fe-Carbidopa complex at 364nm with molar absorptivity of 1600 M-1 cm-1 was observed while that of Fe-Levodopa and Fe-Methyldopa were observed at 730nm with molar absorptivities of 306 M-1 cm-1 and 2300 M-1 cm-1, respectively. Potentiometric studies of the complex indicate that Fe(II) ...

  6. Final report of the AECL/SKB Cigar Lake analog study

    International Nuclear Information System (INIS)

    The Cigar Lake uranium deposit is located in northern Saskatchewan, Canada. The 1.3-billion-year-old deposit is located at a depth of about 450 m below surface in a water-saturated sandstone at the unconformity contact with the high-grade metamorphic rocks of the Canadian Shield. The Cigar Lake deposit has many features that parallel those being considered within the Canadian concept for disposal of nuclear fuel waste. The study of these natural structures and processes provides valuable insight toward the eventual design and site selection of a nuclear fuel waste repository. The main feature of this analog is the absence of any indication on the surface of the rich uranium ore 450 m below. This indicates that the combination of natural barriers has been effective in isolating the uranium ore from the surface environment. More specifically, the deposit provides analog information relevant to the stability of UO2 fuel waste, the performance of clay-based barriers, radionuclide migration, colloid formation, radiolysis, fission-product geochemistry and general aspects of water-rock interaction. The main geochemical studies on this deposit focus on the evolution of groundwater compositions in the deposit and on their redox chemistry with respect to the uranium, iron and sulphide systems. Since 1984, through cooperation from the owners of the Cigar Lake deposit, analog studies have been conducted. AECL, with support from Ontario Hydro under the auspices of the CANDU Owners Group, initiated international participation in 1989 through collaboration with the Swedish Nuclear Fuel and Waste Management Company (SKB) and, more recently, with the Los Alamos National Laboratory (LANL). This report gives the results of the various studies carried out during the 3-year collaboration between AECL and SKB, as well as a summery of the LANL study. It provides detailed information on the generated databases and models, and integrates this information into conclusions for use in safety

  7. Contribution of studies for environmental licensing to the knowledge of Santa Catarina avifauna in southern Brazil

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Guimarães Azevedo

    2006-03-01

    Full Text Available The knowledge generated by studies for environmental licensing, even with reduced field samplings, can contribute to the recording of species of avifauna or actually extends the distribution in places of low knowledge. This study presents data obtained from preliminary reports of impact where the avifauna in seven projects in different ecosystems of Santa Catarina state was diagnosed between January 2001 and January 2004. Sightings had occurred, mainly, by visual or auditory contacts, using binoculars, hand-recorders and field guides. A total of 232 species of birds had been registered, increasing the known distribution by 66 species in different regions of Santa Catarina. The habitat most damaged by entrepreneurial activity was the forest, a factor of concern regarding the conservation of the avifauna that relied upon it. In general, the risk factors associated with the avifauna in Santa Catarina state are environmental degradation, capture of wildlife for breeding in captivity and, hunting for food.

  8. Archaeological analogous and industrials for deep storage: study of the archaeological metallic piece

    International Nuclear Information System (INIS)

    The aim of present research is to obtain information about archaeological analogous of iron and steel, useful for the model of deep geological repository (AGP). The analogous examined have remained buried between 1400 and 2400 years, in very assorted geochemical environments. The extraction of the archaeological pieces has been accomplished according to normalised protocols, trying to carry to the laboratory so the piece as its burial environment, avoiding all possible pollution. Trying to the archaeological analogous could provide valuable information to the AGP model, the study has been directed to related the physical-chemical characteristics of the terrain respect to the deterioration of the archaeological metallic piece. The geology of the surrounding terrain to the archaeological deposit, the geomorphological study of the terrain and data from the analysis of ground: pH, wetness, porosity, organic matter contents, bacteria presence, sulphates, carbonates, chlorides, etc., have allowed to explain the physical-chemical phenomena suffered by the archaeological iron and steel pieces. Also, an exhaustive study of the archaeological piece has been accomplished, concerning the microstructure of the corrosion layer and of the not deteriorated metallic rest. Obtained information concerns different items, such as corrosion velocity and formations of oxide layers, diffusion of chemical elements from the corrosion layer to the metal and viceversa, and structural changes in oxide layers and in the metallic remains by structural ageing. Obtained data have allowed to develop a mathematical model for calculation of corrosion velocity in buried iron and steels, based on physical-chemical variables of grounds, chemical composition and thermomechanical treatment given to the metal during its manufacture. (Author)

  9. Study on analogy between dynamic load and displacement-controlled load

    International Nuclear Information System (INIS)

    Difficulties in handling dynamic load with elastic–plastic analysis and/or structural component test significantly exist in the field of R and D for seismic resistive nuclear pipe systems. In previous studies, the analyses and the structural tests were conducted statically. Many of them have been suggesting conservativeness included in the current seismic criterion of the nuclear design code. Therefore, if analogy between the earthquake load and static displacement are proved, it should bring possibility of more reasonable criterion. The author studied analogy between dynamic load and static displacement using FEM analysis with elastic beam model and elastic–plastic shell model of an elbow. First, the dynamic load equivalent to 160% of ASME/JSME Code’s Level D limit was defined using the elastic beam model. Next, the defined dynamic load was given to the elastic–plastic shell model to acquire the non-linear behaviors such as the relative displacement trend and the plastic strain accumulation at crown of the elbow. Then, three cases of cyclic displacement trends, Case 1, 2 and 3, were defined base on the dynamic analysis results and given to the elastic–plastic shell model statically. Comparison between the dynamic analysis and the static analysis of Case 1 showed clear analogy between the dynamic load and the static displacement. Case 2, however, was found to be difficult to be judged at this moment. Case 3 was conservative throughout the loaded time and suggested possibility of the conservative displacement trend for static structural test without conducting the elastic–plastic analysis.

  10. Salivary amylase and stress during stressful environment: three Mars analog mission crews study.

    Science.gov (United States)

    Rai, Balwant; Kaur, Jasdeep; Foing, Bernard H

    2012-06-14

    After the establishment of the space age physicians, human factors engineers, neurologist and psychologists and their special attention to work on people's capability to meet up the physical, psychological, neuroscience and interpersonal strains of working in space, it has been regarded as an issue that seeks urgent consideration. Not study was conducted on effect of simulated Mars analog environment on stress and salivary amylase. So, this study aimed to confirm whether salivary amylase is act as stress biomarker in crew members who took part in Mars analog mission in an isolated and stressful environment. The 18 crew members were selected who took part in Mars Analog Research Station, Utah. Salivary amylase was measured using a biosensor of salivary amylase monitor and State-Trait Anxiety Inventory score at pre-extravehicular activity, post-extravehicular activity and on before mission. The state and trait anxiety scores at pre-extravehicular activity for each commander were elevated as compared to after extravehicular activity. There were significant differences in the state and trait anxiety scores between before extravehicular activity and after extravehicular activity of Commander and other members, also there were significant differences in values of before-extravehicular activity between commanders and other members. There were significant differences in values of salivary amylase at before extravehicular activity and after extravehicular activity between commander group and other members. There was significant correlation between salivary amylase and state and trait anxiety scores in all groups. Measuring salivary amylase level could be useful for stress assessment of crew members and population working in a stressful and isolated environment. PMID:22554904

  11. Is it time for studying real-life debiasing? Evaluation of the effectiveness of an analogical intervention technique

    OpenAIRE

    Balazs eAczel; Bence eBago; Aba eSzollosi; Andrei eFoldes; Bence eLukacs

    2015-01-01

    The aim of this study was to initiate the exploration of debiasing methods applicable in real-life settings for achieving lasting improvement in decision-making competence regarding multiple decision biases. Here, we tested the potentials of the analogical encoding method for decision debiasing. The advantage of this method is that it can foster the transfer from learning abstract principles to improving behavioral performance. For the purpose of the study, we devised an analogical debiasing ...

  12. Is it time for studying real-life debiasing? Evaluation of the effectiveness of an analogical intervention technique

    OpenAIRE

    Aczel, Balazs; Bago, Bence; Szollosi, Aba; Foldes, Andrei; Lukacs, Bence

    2015-01-01

    The aim of this study was to initiate the exploration of debiasing methods applicable in real-life settings for achieving lasting improvement in decision making competence regarding multiple decision biases. Here, we tested the potentials of the analogical encoding method for decision debiasing. The advantage of this method is that it can foster the transfer from learning abstract principles to improving behavioral performance. For the purpose of the study, we devised an analogical debiasing ...

  13. Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs.

    Science.gov (United States)

    Mazué, Frédéric; Colin, Didier; Gobbo, Jessica; Wegner, Maria; Rescifina, Antonio; Spatafora, Carmela; Fasseur, Dominique; Delmas, Dominique; Meunier, Philippe; Tringali, Corrado; Latruffe, Norbert

    2010-07-01

    Resveratrol is the subject of intense research because of the abundance of this compound in the human diet and as one of the most valuable natural chemopreventive agents. Further advances require new resveratrol analogs be used to identify the structural determinants of resveratrol for the inhibition potency of cell proliferation by comparing experimental and docking studies. Therefore, we synthesized new trans/(E)- and cis/(Z)-resveratrol - analogs not reported to date - by modifying the hydroxylation pattern of resveratrol and a double bond geometry. We included them in a larger panel of 14 molecules, including (Z)-3,5,4'-trimethoxystilbene, the most powerful molecule that is used as reference. Using a docking model complementary to experimental studies on the proliferation inhibition of the human colorectal tumor SW480 cell line, we show that methylation is the determinant substitution in inhibition efficacy, but only in molecules bearing a Z configuration. Most of the synthetic methylated derivatives (E or Z) stop mitosis at the M phase and lead to polyploid cells, while (E)-resveratrol inhibits cells at the S phase. Docking studies show that almost all of the docked structures of (Z)-polymethoxy isomers, but not most of the (E)-polymethoxy isomers substantially overlap the docked structure of combretastatin A-4, taken as reference ligand at the colchicine-tubulin binding site. PMID:20395019

  14. The Influence of Fees on Supervision of Licensed Professional Counselor Interns in Texas: A Mixed-Methods Study

    Science.gov (United States)

    Stark, Marcella Dortch

    2010-01-01

    Purpose. The purpose of this study was to explore the influence of payment status on perceptions of Licensed Professional Counselor (LPC) Interns regarding aspects of the supervisory relationship. Method. Survey responses from 230 LPC Interns in Texas were collected using SurveyMonkey[TM] (2009) to examine how supervision fees influence: (a)…

  15. Bioprinting of Micro-Organ Tissue Analog for Drug Metabolism Study

    Science.gov (United States)

    Sun, Wei

    An evolving application of tissue engineering is to develop in vitro 3D cell/tissue models for drug screening and pharmacological study. In order to test in space, these in vitro models are mostly manufactured through micro-fabrication techniques and incorporate living cells with MEMS or microfluidic devices. These cell-integrated microfluidic devices, or referred as microorgans, are effective in furnishing reliable and inexpensive drug metabolism and toxicity studies [1-3]. This paper will present an on-going research collaborated between Drexel University and NASA JSC Radiation Physics Laboratory for applying a direct cell printing technique to freeform fabrication of 3D liver tissue analog in drug metabolism study. The paper will discuss modeling, design, and solid freeform fabrication of micro-fluidic flow patterns and bioprinting of 3D micro-liver chamber that biomimics liver physiological microenvironment for enhanced drug metabolization. Technical details to address bioprinting of 3D liver tissue analog, integration with a microfluidic device, and basic drug metabolism study for NASA's interests will presented. 1. Holtorf H. Leslie J. Chang R, Nam J, Culbertson C, Sun W, Gonda S, "Development of a Three-Dimensional Tissue-on-a-Chip Micro-Organ Device for Pharmacokinetic Analysis", the 47th Annual Meeting of the American Society for Cell Biology, Washington, DC, December 1-5, 2007. 2. Chang, R., Nam, J., Culbertson C., Holtorf, H., Jeevarajan, A., Gonda, S. and Sun, W., "Bio-printing and Modeling of Flow Patterns for Cell Encapsulated 3D Liver Chambers For Pharmacokinetic Study", TERMIS North America 2007 Conference and Exposition, Westin Harbour Castle, Toronto, Canada, June 13-16, 2007. 3.Starly, B., Chang, R., Sun, W., Culbertson, C., Holtorf, H. and Gonda, S., "Bioprinted Tissue-on-chip Application for Pharmacokinetic Studies", Proceedings of World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, PA, USA, April 24-27, 2006.

  16. A study of the validity of the Korean Nurses' Licensing Examination

    Directory of Open Access Journals (Sweden)

    Hyang Yeon Lee

    2005-06-01

    Full Text Available This study tested the validity of subjects in the Korean Nurses' Licensing Examination (KNLE. To determine the validity of test items in the KNLE, the items testing each subject in the examination and all of the test items were compared. The homogeneity and proper degree of conceptual diversity of the items in the examination were tested by comparing the frameworks of the test items in the National Council Licensure Examination for Registered Nurses (NCLEX-RN and the KNLE. The validity of the KNLE was determined by examining the correlations between the scores that the same individuals obtained on the KNLE in 2002 and their college marks. This study showed that basic core items appeared repeatedly in the KNLE, and items in the examination were selected according to the importance of each subject examined. Therefore, a new test system based on united subjects should be considered to solve these problems. Further studies are needed to develop a framework for classifying the test items that should be included as united subjects through considering the job description and goals of study of nurses.

  17. Final report of the AECL/SKB Cigar Lake analog study

    International Nuclear Information System (INIS)

    The Cigar Lake uranium deposit is located in northern Saskatchewan, Canada. The 1.3-billion-year-old deposit is located at a depth of about 450 m below surface in a water-saturated sandstone at the unconformity contact with the high-grade metamorphic rocks of the Canadian Shield. The uranium mineralization, consisting primarily of uraninite (UO2), is surrounded by a clay-rich halo in both sandstone and basement rocks, and remains extremely well preserved and intact. The average grade of the mineralization is ∼ 8 wt.% U; locally grades are as high as ∼ 55 wt.%U. The Cigar lake deposit has many features that parallel those being considered within the Canadian concept for disposal of nuclear fuel waste. Specifically, the deposit provides analog information relevant to the stability of UO2 fuel waste, the performance of clay-based barriers, radionuclide migration, colloid formation, radiolysis, fission-product geochemistry and general aspects of water-rock interaction. The main geochemical studies on this deposit focus on the evolution of groundwater compositions in the deposit and on their redox chemistry with respect to the uranium, iron and sulphide systems. Since 1984, through cooperation from the owners of the Cigar lake deposit, analog studies have been conducted. AECL, with support from Ontario Hydro under the auspices of the CANDU Owners Group, initiated international participation in 1989 through collaboration with the Swedish Nuclear Fuel and Waste Management Company (SKB) and, more recently, with the Los Alamos National Laboratory (LANL). This report gives the results of the various studies carried out during the 3-year collaboration between AECL and SKB, as well as a summary of the LANL study. It provides detailed information on the generated databases and models, and integrates this information into conclusions for use in safety assessment of the Canadian, Swedish and United States disposal concepts. 15 refs., 25 figs., 55 tabs

  18. The Cigar Lake analog study: an international R and D Project

    International Nuclear Information System (INIS)

    The Cigar Lake analog study has provided valuable information and insight on a number of safety aspects in the Canadian nuclear fuel waste disposal concept. Some important general conclusions are as follows: uranium dioxide is stable under reducing conditions over geological time; clay (in this case illite) can provide sealing and is an efficient barrier to radionuclide and colloid migration; colloids were not important in radionuclide migration; organics and microbes are unlikely to adversely affect radionuclide migration in the near field; clay minerals control the bulk composition of groundwater, its redox geochemistry being controlled by iron and sulfur; radiolytic oxidation of uranium dioxide is overemphasized in some models. 11 refs., 3 figs., 1 tab

  19. Learners' Use of Analogy and Alternative Conceptions for Chemical Bonding: A Cross-Age Study.

    Science.gov (United States)

    Coll, Richard K.; Treagust, David F.

    2002-01-01

    Describes Australian secondary school, undergraduate, and postgraduate students' use of analogy and anthropomorphism along with their alternative conceptions for mental models of chemical bonding. Finds that learners make use of analogy and anthropomorphism to aid their explanations of chemical bonding, and in addition reveals that learners across…

  20. Interferon Analogs

    NARCIS (Netherlands)

    Poelstra, Klaas; Prakash, Jai; Beljaars, Eleonora; Bansal, Ruchi

    2015-01-01

    The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least

  1. Interferon Analogs

    NARCIS (Netherlands)

    Poelstra, Klaas; Prakash, Jai; Beljaars, Leonie; Bansal, Ruchi

    2010-01-01

    The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least

  2. Insulin analogs and cancer

    Directory of Open Access Journals (Sweden)

    Laura eSciacca

    2012-02-01

    Full Text Available Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time course of the effect. Modifications in the amino acid sequence of the insulin molecule change the pharmacokinetics and pharmacodynamics of the analogs in respect to human insulin. However, these changes can also modify the molecular and biological effects of the analogs. The rapid-acting insulin analogs, lispro, aspart and glulisine, have a rapid onset and shorter duration of action. The long-acting insulin analogs glargine and detemir have a protracted duration of action and a relatively smooth serum concentration profile. Insulin and its analogs may function as growth factors and therefore have a theoretical potential to promote tumor proliferation. A major question is whether analogs have an increased mitogenic activity in respect to insulin. These ligands can promote cell proliferation through many mechanisms like the prolonged stimulation of the insulin receptor, stimulation of the IGF-1 receptor (IGF-1R, prevalent activation of the ERK rather than the AKT intracellular post-receptor pathways. Studies on in vitro models indicate that short-acting analogs elicit molecular and biological effects that are similar to those of insulin. In contrast, long-acting analogs behave differently. Although not all data are homogeneous, both glargine and detemir have been found to have a decreased binding to IR but an increased binding to IGF-1R, a prevalent activation of the ERK pathway, and an increased mitogenic effect in respect to insulin. Recent retrospective epidemiological clinical studies have suggested that treatment with long-acting analogs (specifically glargine may increase the relative risk for cancer. Results are controversial and methodologically weak. Therefore prospective clinical studies are needed to evaluate the possible tumor growth-promoting effects of these insulin

  3. Evaluation of long-acting somatostatin analog injection devices by nurses: a quantitative study

    Directory of Open Access Journals (Sweden)

    Adelman DT

    2012-12-01

    Full Text Available Daphne T Adelman,1 Andrea Burgess,2 Philippa R Davies,31Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 2Neuroendocrine Tumor Department, The Christie, Manchester, UK; 3Neuroendocrine Tumor Unit, Royal Free Hospital, London, UKAbstract: The somatostatin analogs (SSAs lanreotide Autogel/Depot and octreotide long-acting release are used to treat acromegaly and neuroendocrine tumors. The present study evaluated opinions on SSA injection devices, including a recently approved lanreotide new device (lanreotide-ND, among nurses in Europe and the USA. Nurses injecting SSAs for at least three patients per year (n = 77 were interviewed regarding SSA devices. Device attributes were rated via questionnaire; nurses were then timed administering test injections with lanreotide-ND and octreotide long-acting release. The most important delivery system attributes were easy/convenient preparation and injection (ranked in the top five by 70% of nurses, low clogging risk (58%, and high product efficacy (55%. Compared with the octreotide long-acting release device, lanreotide-ND scored higher on 15/16 attributes, had shorter mean preparation and administration time (329 versus 66 seconds, respectively; P ≤ 0.01 and a higher overall preference score (70 versus 114, respectively; P ≤ 0.01. The five most important lanreotide-ND attributes were: prefilled device, confidence a full dose was delivered, low clogging risk, easy/convenient preparation and injection, and fast administration. These device features could lead to improvements in clinical practice and benefit patients/caregivers who administer SSAs at home.Keywords: nurse, somatostatin analog, device, lanreotide, octreotide

  4. Comparative study of the binding of Trypsin with bifendate and analogs by spectrofluorimetry

    Science.gov (United States)

    Li, Hua; Pu, Juanjuan; Wang, Yi; Liu, Chuang; Yu, Jie; Li, Tao; Wang, Ruiqiang

    2013-11-01

    The interactions between Trypsin and bifendate (DDB) or analogs (I, II and III) were investigated by fluorescence, UV-visible absorption, resonance light scattering, synchronous fluorescence and 3D spectroscopy under mimic physiological conditions. The results revealed that DDB and analogs caused the fluorescence quenching of Trypsin by the formation of DDB/I/II/III-Trypsin complex. The quenching and energy transfer mechanisms were discussed. The binding constants and thermodynamic parameters at three different temperatures were obtained. The hydrophobic interaction was the predominant intermolecular forces to stabilize the complex. Results showed that DDB was the stronger quencher and bound to Trypsin with higher affinity than other three analogs.

  5. Spectroscopic study on the interaction of Trypsin with Bicyclol and analogs

    Science.gov (United States)

    He, Wu; Dou, Huanjing; Zhang, Lu; Wang, Lvjing; Wang, Ruiyong; Chang, Junbiao

    2014-01-01

    The interactions between Trypsin and Bicyclol or analogs (Bifendate, I, II and III) were investigated by spectrophotometric methods. It was found that Bicyclol or analogs had strong ability to quench the intrinsic fluorescence of Trypsin by a static quenching procedure. The binding constants were obtained at three temperatures. The thermodynamics parameters reveal that the hydrophobic and electrostatic interactions play an important role in the interaction. Results showed that the microenvironments of tryptophan residue of Trypsin were disturbed by the analogs. Results indicated that Bifendate was the strongest quencher among five compounds.

  6. Hole Burning Imaging Studies of Cancerous and Analogous Normal Ovarian Tissues Utilizing Organelle Specific Dyes

    Energy Technology Data Exchange (ETDEWEB)

    Satoshi Matsuzaki

    2004-12-19

    Presented in this dissertation is the successful demonstration that nonphotochemical hole burning (NPWB) imaging can be used to study in vitro tissue cellular systems for discerning differences in cellular ultrastructures due to cancer development. This has been accomplished with the surgically removed cancerous ovarian and analogous normal peritoneal tissues from the same patient and the application of a fluorescent mitochondrion specific dye, Molecular Probe MitoFluor Far Red 680 (MF680), commonly known as rhodamine 800, that has been proven to exhibit efficient NPHB. From the results presented in Chapters 4 and 5 , and Appendix B, the following conclusions were made: (1) fluorescence excitation spectra of MF680 and confocal microscopy images of thin sliced tissues incubated with MF680 confirm the site-specificity of the probe molecules in the cellular systems. (2) Tunneling parameters, {lambda}{sub 0} and {sigma}{sub {lambda}}, as well as the standard hole burning parameters (namely, {gamma} and S), have been determined for the tissue samples by hole growth kinetics (HGK) analyses. Unlike the preliminary cultured cell studies, these parameters have not shown the ability to distinguish tissue cellular matrices surrounding the chromophores. (3) Effects of an external electric (Stark) field on the nonphotochemical holes have been used to determine the changes in permanent dipole moment (f{Delta}{mu}) for MF680 in tissue samples when burn laser polarization is parallel to the Stark field. Differences are detected between f{Delta}{mu}s in the two tissue samples, with the cancerous tissue exhibiting a more pronounced change (1.35-fold increase) in permanent dipole moment change relative to the normal analogs. It is speculated that the difference may be related to differences in mitochondrial membrane potentials in these tissue samples. (4) In the HGK mode, hole burning imaging (HBI) of cells adhered to coverslips and cooled to liquid helium temperatures in the

  7. Gene patents and licensing: case studies prepared for the Secretary's Advisory Committee on Genetics, Health, and Society.

    Science.gov (United States)

    Cook-Deegan, Robert; Heaney, Christopher

    2010-04-01

    Researchers at the Center for Public Genomics at Duke University analyzed how patenting and licensing affect clinical access to genetic testing in the United States. The research was requested by the Secretary's Advisory Committee on Genetics, Health, and Society. Conditions studied were breast and ovarian cancers, colon cancers, Alzheimer disease, cystic fibrosis, hearing loss, hereditary hemochromatosis, long QT syndrome, spinocerebellar ataxia, Tay-Sachs disease, and Canavan disease. PMID:20393303

  8. Gene Patents and Licensing: Case Studies Prepared for the Secretary's Advisory Committee on Genetics, Health, and Society

    OpenAIRE

    Cook-Deegan, Robert; Heaney, Christopher

    2010-01-01

    Researchers at the Center for Public Genomics (CpG) at Duke University analyzed how patenting and licensing affect clinical access to genetic testing in the United States. The research was requested by the Secretary's Advisory Committee on Genetics, Health, and Society (SACGHS). Conditions studied were breast and ovarian cancers, colon cancers, Alzheimer's disease, cystic fibrosis, hearing loss, hereditary hemochromatosis, Long QT syndrome, spinocerebellar ataxia, Tay-Sachs disease, and Canav...

  9. A Post Licensing Study of Community Effects at Two Operating Nuclear Power Plants. Final Report.

    Science.gov (United States)

    Purdy, Bruce J.; And Others

    In an effort to identify and assess the social, economic, and political effects of nuclear power plant construction and operation upon two host communities (Plymouth, Massachusetts and Waterford, Connecticut), a post-licensing review revealed that the primary impact of the nuclear power plants in both communities was an increase in the property…

  10. Feasibility Study of a WCDMA direct air-to-ground link in the UMTS licensed band

    OpenAIRE

    Raghavarapu, Dora Swamy Naidu

    2006-01-01

    The aim of this master's thesis is to assess the feasibility of UMTS for aeronautical communications. Specifically, we wish to determine how existing UMTS networks may be accessed by aircraft with a direct air-to-ground communications link based on the UMTS radio interface technology (Wideband CDMA) and using the same licensed spectrum as on the ground.

  11. Millimeter Wave Studies of Analogs to Optical Phenomena in Ferroelectric Crystals and Artificial Kerr Media.

    Science.gov (United States)

    Bobbs, Bradley Lance

    Refractive, absorptive, electrooptical, and nonlinear optical phenomena have traditionally been associated with visible light, but can readily be extended to include analogs for millimeter wave radiation. Studies of such analog phenomena can reveal material properties with remarkable enhancements over corresponding properties in the visible spectrum. This is particularly true for materials grown or developed specifically for millimeter wave applications. One class of materials investigated was tungsten bronze ferroelectric crystals. Indices of absorption and refraction of Sr_{rm x} Ba_{rm 1-x}Nb _2O_6 and Ba_{rm 2-x}Sr _{rm x}K_ {rm1-y}Na_{ rm y}Nb_5O _{15} at millimeter wave frequencies between 55 and 110 GHz and temperatures between 20 and 300K were derived from measurements of transmittance spectra containing Fabry-Perot fringes produced by crystal surface reflections. The anisotropies observed in both indices at these frequencies are huge compared with those at optical frequencies. Absorption in both materials decreases markedly upon cooling, but only for incident waves polarized along the crystal polar axis. Measurements of linear electrooptic modulation show this effect to be quite large at 300 K, but indicate a significant reduction upon cooling. An artificial Kerr medium consisting of a suspension of short graphite fibers was shown to provide an effective means for observing nonlinear millimeter wave interactions. Using a 18 GHz pump beam with up to 20 W continuous power, changes in the 94 GHz refractive index were measured by interferometry. The induced birefringence and anisotropic absorption indicate an alignment of the fibers with the electric field of the pump beam. The resulting nonlinear refractive index is predicted to be of sufficient magnitude to demonstrate millimeter wave bistability and phase conjugation by degenerate four-wave mixing. Although theoretical model fits to the experimental results show a reasonable degree of success, they also

  12. Combined Kinetic Studies and Computational Analysis on Kojic Acid Analogs as Tyrosinase Inhibitors

    Directory of Open Access Journals (Sweden)

    Carlyle Ribeiro Lima

    2014-07-01

    Full Text Available Tyrosinase is a key enzyme in melanin synthesis and widely distributed in plants and animals tissues. In mammals, this enzyme is related to pigment production, involved in wound healing, primary immune response and it can also contribute to catecholamines synthesis in the brain. Consequently, tyrosinase enzyme represents an attractive and selective target in the field of the medicine, cosmetics and bio-insecticides. In this paper, experimental kinetics and computational analysis were used to study the inhibition of tyrosinase by analogous of Kojic acid. The main interactions occurring between inhibitors-tyrosinase complexes and the influence of divalent cation (Cu2+ in enzymatic inhibition were investigated by using molecular docking, molecular dynamic simulations and electrostatic binding free energy by using the Linear Interaction Energy (LIE method. The results showed that the electrostatic binding free energy are correlated with values of constant inhibition (r2 = 0.97.Thus, the model obtained here could contribute to future studies of this important system and, therefore, eventually facilitate development of tyrosinase inhibitors.

  13. Metabolism of radiohafnium in rats and hamsters: a possible analog of plutonium for metabolic studies

    International Nuclear Information System (INIS)

    The metabolism of radiohafnium (175Hf + 181Hf) was studied in male Sprague-Dawley rats and Chinese hamsters for periods of up to 168 days. The results were compared with similar data for 239Pu in the same rat strain. In rats and hamsters the radiohafnium organ distribution was skeleton > skin > muscle > liver at about 7 days postinjection. Retention of radiohafnium and plutonium was similar in plasma and liver, as were the retention time observed for other organs: Absorption of radiohafnium from the gastrointestinal tract of rats was <0.05%. Biochemical studies showed that the radiohafnium was bound mainly to the iron-transport protein, transferrin, in blood plasma and in the liver cytosol of both the rat and the hamster, as has been observed also for plutonium. The metabolic behavior of radiohafnium mimics, to a large extent, that of plutonium, and it is suggested that radiohafnium can serve as a non-α-particle-emitting analog of plutonium for metabolic, biochemical, and selected human investigations

  14. The metabolism of radiohafnium in rats and hamsters: a possible analog of plutonium for metabolic studies

    International Nuclear Information System (INIS)

    The metabolism of radiohafnium (175Hf + 181Hf) was studied in male Sprague-Dawley rats and Chinese hamsters for periods of up to 168 days. The results were compared with similar data for 239Pu in the same rat strain. In rats and hamsters the radiohafnium organ distribution was skeleton greater than skin greater than muscle greater than liver at about 7 days postinjection. Retention of radiohafnium and plutonium was similar in plasma and liver, as were the retention times observed for other organs: Absorption of radiohafnium from the gastrointestinal tract of rats was less than 0.05%. Biochemical studies showed that the radiohafnium was bound mainly to the iron-transport protein, transferrin, in blood plasma and in the liver cytosol of both the rat and the hamster, as has been observed also for plutonium. The metabolic behavior of radiohafnium mimics, to a large extent, that of plutonium, and it is suggested that radiohafnium can serve as a non-alpha-particle-emitting analog of plutonium for metabolic, biochemical, and selected human investigations

  15. Importance of correction for intravascular radioactivity in dynamic PCT studies using glucose analogs

    International Nuclear Information System (INIS)

    Recently, there has been considerable controversy concerning the accuracy of single scan approaches for estimating glucose metabolic rate. An alternative is to acquire a dynamic sequence of PCT data to estimate the individual rate constants of the conventional 4-parameters model. A model developed that accounts not only for the arterial blood radioactivity, but also for the venous blood radioactivity which itself depends on the local blood flow value, the individual plasma and RBC components of the blood radioactivity, the hematocrit, and the transport rate constants k/sub 1/ and k/sub 2/. Computer simulations predict overestimation in k/sub 1/, k/sub 2/ and k/sub 3/ of 30%, 40%, and 20%, respectively. The overestimation in the estimated metabolic rate, which is proportional to the term k/sub 1/k/sub 3//(k/sub 2/+k/sub 3/), was less than 16%. Parameter values for PCT studies on human subjects using 2-FDG and 3-FDG were evaluated with and without corrections for blood-horns radioactivity. Percent overestimations were similar for both analogs. Results from human studies are in good agreement with those predicted by computer simulation

  16. Click-based synthesis of bromotyrosine alkaloid analogs as potential anti-biofilm leads for SAR studies.

    Science.gov (United States)

    Andjouh, S; Blache, Y

    2015-12-15

    A library of triazole-based analogs of bromotyramine alkaloids such as verongamines, hemibastadins, pseudoceramine D and clavatidine E was designed in order to identify promising leads that may help in the control of bacterial biofilms. Twenty-three compounds were screened for their biofilm inhibitory activity against three strains of Gram-negative bacteria. SAR studies revealed that hemibastadins analogs were the most active compounds which act as inhibitors of biofilm development (EC50 8.8-29μM) without effect on bacterial growth even at high concentrations (100μM). PMID:26564265

  17. Femtosecond Heterodyne Transient Grating Spectroscopic Studies of Intramolecular Charge Transfer Character of Peridinin and Peridinin Analogs

    Science.gov (United States)

    Bishop, Michael; Khosravi, Soroush; Obaid, Razib; Whitelock, Hope; Carroll, Ann Marie; Lafountain, Amy; Frank, Harry; Beck, Warren; Gibson, George; Berrah, Nora

    2016-05-01

    The peridinin chlorophyll-a protein is a light harvesting complex found in several species of dinoflagellates. Peridinin absorbs strongly in the mid-visible spectral region and, despite the lack of a strong permanent dipole moment in its lowest energy excited state, is able to transfer excitation energy quickly and efficiently to chlorophyll-a. It is believed that the high efficiency arises from the development of intramolecular charge-transfer (ICT) character upon photoexcitation. Recently, heterodyne transient grating spectroscopy has been used to study the ultrafast (ICT character in the case of peridinin, but up to now the work has not provided appropriate control experiments. The present experiments examine peridinin and two peridinin analogs, S1-peridinin and S2-peridinin. S1-peridinin is reported to have greatly diminished ICT character, and S2-peridinin is reported to have little-or-no ICT character. Heterodyne transient grating data will be presented and provide a more unambiguous characterization spectral and kinetic properties associated with the peridinin ICT state. Funded by the DoE-BES, Grant No. DE-SC0012376.

  18. Analog model

    International Nuclear Information System (INIS)

    The invention relates to devices for modelling the space-dependent kinetics of a nuclear reactor. It can be advantageously used in studying the dynamics of the neutron field in the core to determine the effect of the control rods on the power distribution in the core, for training purposes. The proposed analog model of a nuclear reactor comprises operational amplifiers and a grid of resistors simulating neutron diffusion. Connected to the grid nodes are supply resistors modelling absorption and multiplication of neutrons. This is achieved by that, in the proposed model, all resistors through which power is supplied to the grid nodes are interconnected by their other leads and coupled to the output of the amplifier unit common for all nodes. Therewith, the amlifier unit models the transfer function of a ''point'' reactor. Connected to the input of this unit which includes two to four amplifiers are resistors for addition of signals with a grid node. Coupled to the grid nodes via additional resistors are voltage sources simulating reactivity

  19. 3D-QSAR study of 20 (S)-camptothecin analogs

    Institute of Scientific and Technical Information of China (English)

    Ai-jun LU; Zhen-shan ZHANG; Ming-yue ZHENG; Han-jun ZOU; Xiao-min LUO; Hua-liang JIANG

    2007-01-01

    Aim: To build up a quantitative structure-activity relationship (QSAR) model of20 (S)-camptothecin (CPT) analogs for the prediction of the activity of new CPT analogs for drug design. Methods: A training set of 43 structurally diverse CPT analogs which were inhibitors of topoisomerase Ⅰ were used to construct a quan-titative structure-activity relationship model with a comparative molecular field analysis (CoMFA). The QSAR model was optimized using partial least squares(PLS) analysis. A test set of 10 compounds was evaluated using the model. Results: The CoMFA model was constructed successfully, and a good cross-validated correlation was obtained in which q2 was 0.495. Then, the analysis of the non-cross-validated PLS model in which r2 was 0.935 was built and permitted demonstrations of high predictability for the activities of the 10 CPT analogs in the test set selected in random. Conclusion: The CoMFA model indicated that bulky negative-charged group at position 9, 10 and 11 of CPT would increase activity, but excessively increasing bulky group at position 10 is adverse to inhibi-tory activity; substituents that occupy position 7 with the bulky positive group will enhance the inhibitive activity. The model can be used to design new CPT analogs and understand the mechanism of action.

  20. Moped collisions among patients with revoked drivers' licenses are a significant public health problem: a retrospective cohort study.

    Science.gov (United States)

    Braun, Benjamin M; Gries, Lynn M; Hildreth, Amy N; Miller, Anna N

    2014-08-01

    Many states do not require a license to operate a moped, defined as a motor vehicle with less than 50-cc engine displacement. These vehicles may therefore serve as a mode of transportation for those who are driving without a license and who may have a history of prior high-risk behavior. We hypothesized that those involved in moped collisions were more likely to have previous convictions for driving while intoxicated (DWI) and other non-DWI offenses than those on conventional motorcycles. At a Level I trauma center, we queried the trauma registry from January 2005 to October 2010 for admissions after motorcycle or moped collisions. Classification of mechanism of injury was verified through chart review. Corrections databases from our state were then reviewed for previous convictions for DWI and other offenses. One thousand seventy-three patients over the study period were involved in motorcycle or moped collisions; 94 were from another state. Of the patients identified from our state, 249 had moped collisions and 730 had motorcycle collisions. Forty-nine per cent (121) of moped drivers had a history of DWI versus only 8 per cent (56) of motorcycle drivers (P ≤ 0.05). Sixty-four per cent (161) of moped drivers were previously convicted of a crime versus 20 per cent (146) of those on motorcycles (P ≤ 0.05). Moped drivers were significantly more likely to have a prior conviction of DWI as well as prior convictions of other crimes, establishing a pattern of disregard for the law. The use of these vehicles without a license likely presents a risk to public safety. Legislation to require licensing before moped operation should be considered. PMID:25105400

  1. Analog earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, R.B. [Center for Nuclear Waste Regulatory Analyses, San Antonio, TX (United States)

    1995-09-01

    Analogs are used to understand complex or poorly understood phenomena for which little data may be available at the actual repository site. Earthquakes are complex phenomena, and they can have a large number of effects on the natural system, as well as on engineered structures. Instrumental data close to the source of large earthquakes are rarely obtained. The rare events for which measurements are available may be used, with modfications, as analogs for potential large earthquakes at sites where no earthquake data are available. In the following, several examples of nuclear reactor and liquified natural gas facility siting are discussed. A potential use of analog earthquakes is proposed for a high-level nuclear waste (HLW) repository.

  2. Contractual Solutions in Electronic Publishing Industry: A Comparative study of License Agreements

    OpenAIRE

    K.T. Anuradha; B M Meera

    2005-01-01

    Information Technology (IT) revolution has brought global change and has impact on electronic publishing industry also. In the digital and networked environment, publishers are concerned about protecting their products from illegal use. Copyright has been proclaimed as an important weapon by the publishers to safeguard their products. In view of the increasing importance that is gained by contract law in electronic publishing, more and more libraries are engaged in signing License Agreements ...

  3. Study of the interaction between bovine hemoglobin and analogs of biphenyldicarboxylate by spectrofluorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ruiyong, E-mail: wangry@zzu.edu.cn [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China); Yin, Yujing [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China); Wang, Ruiqiang [The First Afficiated Hospiatal of Zhengzhou University, Zhengzhou 450052 (China); Xie, Yuanzhe; Ge, Baoyu; Li, Zhigang; Li, Zhen; Shi, Jie [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China); Chang, Junbiao, E-mail: changjunbiao@zzu.edu.cn [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China)

    2013-12-15

    The interaction between bovine hemoglobin and analogs of Biphenyldicarboxylate was investigated by fluorescence, synchronous fluorescence, ultraviolet–vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra at pH 7.40. The quenching mechanism and binding constants were determined by the quenching of bovine hemoglobin fluorescence in presence of analogs. Results showed that the nature of the quenching was of static type. Both the van der Waals and hydrogen bonding played a major role in stabilizing the complex. The distance between donor and acceptors was obtained to be 2.11–2.25 nm according to Förster's theory. The influence of analogs on the conformation of bovine hemoglobin was investigated. -- Highlights: • The interactions between bovine hemoglobin and analogs of DDB have been investigated. • Results reveal that DDB has the strongest affinity for hemoglobin among four compounds. • The van der Waals and hydrogen bonding play major role in the binding process. • The influence of molecular structure on the binding aspects has been investigated.

  4. Study of the interaction between bovine hemoglobin and analogs of biphenyldicarboxylate by spectrofluorimetry

    International Nuclear Information System (INIS)

    The interaction between bovine hemoglobin and analogs of Biphenyldicarboxylate was investigated by fluorescence, synchronous fluorescence, ultraviolet–vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra at pH 7.40. The quenching mechanism and binding constants were determined by the quenching of bovine hemoglobin fluorescence in presence of analogs. Results showed that the nature of the quenching was of static type. Both the van der Waals and hydrogen bonding played a major role in stabilizing the complex. The distance between donor and acceptors was obtained to be 2.11–2.25 nm according to Förster's theory. The influence of analogs on the conformation of bovine hemoglobin was investigated. -- Highlights: • The interactions between bovine hemoglobin and analogs of DDB have been investigated. • Results reveal that DDB has the strongest affinity for hemoglobin among four compounds. • The van der Waals and hydrogen bonding play major role in the binding process. • The influence of molecular structure on the binding aspects has been investigated

  5. Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase

    DEFF Research Database (Denmark)

    Mikkelsen, Niels Egil; Munch-Petersen, Birgitte; Eklund, Hans

    2008-01-01

    relate them to the binding of substrate and feedback inhibitors. dCTP and dGTP binds similarly as the feedback inhibitor dTTP with the base in the substrate site. All investigated nucleoside analogs bind similarly as the pyrimidine substrates with many interactions in common. In contrast, the base of d...

  6. Studies on the Synthesis of a Natural Product-Piceatannol and its Analogs

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Piceatannol, (E)-3, 3(, 4, 5(-tetrahydroxy stilbene, a natural polyhydroxy stilbene, possesses many biological activities, its synthesis has been reported. We designed another route of its synthesis, which can be controlled more easily. The synthetic product was characterized by elemental analysis, IR, MS and 1H-NMR. Its analogs were synthesized by the similar method.

  7. In vitro and In vivo Studies on Stilbene Analogs as Potential Treatment Agents for Colon Cancer

    Science.gov (United States)

    Based upon the potential of resveratrol as a cancer chemopreventive agent, 27 stilbenes analogs were synthesized and tested against colon cancer cell line HT-29. Among these compounds, amino derivative (Z)-4-(3,5-dimethoxystyryl) aniline (4), (Z)-methyl 4-(3,5-dimethoxystyryl) benzoate (6) and (Z)-1...

  8. A Computational Study on Thiourea Analogs as Potent MK-2 Inhibitors

    Directory of Open Access Journals (Sweden)

    Guohui Li

    2012-06-01

    Full Text Available Mitogen-activated protein kinase-activated protein kinase 2 (MK-2 has been identified as a drug target for the treatment of inflammatory diseases. Currently, a series of thiourea analogs as potent MK-2 inhibitors were studied using comprehensive computational methods by 3D-QSAR, molecular docking and molecular dynamics simulations for a further improvement in activities. The optimal 3D models exhibit high statistical significance of the results, especially for the CoMFA results with r2ncv, q2 values of 0.974, 0.536 for the internal validation, and r2pred, r2m values of 0.910, 0.723 for the external validation and Roy’s index, respectively. In addition, more rigorous validation criteria suggested by Tropsha were also employed to check the built models. Graphic representation of the results, as contoured 3D coefficient plots, also provides a clue to the reasonable modification of molecules: (i The substituent with a bulky size and electron-rich group at the C5 position of the pyrazine ring is required to enhance the potency; (ii The H-bond acceptor group in the C3 position of the pyrazine ring is likely to be helpful to increase MK-2 inhibition; (iii The small and electropositive substituent as a hydrogen bond donor of the C2 position in the oxazolone ring is favored; In addition, several important amino acid residues were also identified as playing an important role in MK-2 inhibition. The agreement between 3D-QSAR, molecular docking and molecular dynamics simulations also proves the rationality of the developed models. These results, we hope, may be helpful in designing novel and potential MK-2 inhibitors.

  9. Analog-model studies of ground-water hydrology in the Houston District, Texas

    Science.gov (United States)

    Jorgensen, Donald G.

    1974-01-01

    The major water-bearing units in the Houston district are the Chicot and the Evangeline aquifers. The Chicot aquifer overlies the Evangeline aquifer, which is underlain by the Burkeville confining layer. Both aquifers consist of unconsolidated and discontinuous layers of sand and clay that dip toward the Gulf of Mexico. Heavy pumping of fresh water has caused large declines in the altitudes of the potentiometric surfaces in both aquifers and has created large cones of depression around Houston. The declines have caused compaction of clay layers, which has resulted in land surface subsidence and the movement of saline ground water toward the centers of the cones of depression. An electric analog model was used to study the hydrologic system and to simulate the declines in the altitudes of the potentiometric surfaces for several alternative plans of ground-water development. The results indicate that the largest part. of the pumped water comes from storage in the water-table part of the Chicot aquifer. Vertical leakage from the aquifers and water derived from the compaction of clay layers in the aquifers are also large sources of the water being pumped. The response of the system, as observed on the model, indicates that development of additional ground-water supplies from the water-table part of the Chicot aquifer north of Houston would result in a minimum decline of the altitudes of the potentiometric surfaces. Total withdrawals of about 1,000 million gallons (5.8 million cubic meters) per day may be possible without seriously, increasing subsidence or salt-water encroachment. Analyses of the recovery of water levels indicate that both land-surface subsidence and salt-water encroachment could be reduced by artificially recharging the artesian part of the aquifer.

  10. Making the best of licensing partnerships with diverse corporate cultures. A case study.

    OpenAIRE

    Vollner, Natalie

    2016-01-01

    This thesis explores what makes licensing partnerships with diverse corporate cultures successful and wherein lie the challenges of having different corporate cultures. Corporate cultures have been named  as  one  of the key reasons behind the success or failure of mergers and acquisitions, but there is far less research on the impact of corporate cultures in partnerships, which makes it a relevant topic to research. The research objective is to create a better understanding of what factors f...

  11. Hints of Habitable Environments on Mars Challenge Our Studies of Mars-Analog Sites on Earth

    Science.gov (United States)

    desMarais, David J

    2009-01-01

    environments persisted in the near-subsurface for hundreds of millions of years and might exist even today. Studies of Mars-analog environments must better understand subsurface nonphotosynthetic ecosystems and their biosignatures in mafic and ultramafic terranes. Studies must determine minimum needs for water activity and energy and also establish survival limits when conditions that support active metabolism and propagation become progressively less frequent over time.

  12. EXTENSION THROUGH ANALOGY A USEFUL METHOD IN THE STUDY OF DISPARITIES

    Directory of Open Access Journals (Sweden)

    Viorica PUSCACIU

    2006-01-01

    Full Text Available The method of extension through analogy is, in our view, useful for comparisons between miscellaneous economical indicators belonging to the same structure, also between indicators which belongs to various economical areas like cities, regions, countries. Taking into account Romania’s admission to the European Union, this method would establish the extant temporary disparities and would impress those responsible in the political economy. As a novelty we present it inthe context of square trends.

  13. Understanding Licensing Behavior

    DEFF Research Database (Denmark)

    Cabaleiro, Goretti; Moreira, Solon; Reichstein, Toke

    The potential for rent dissipation has been argued to be the main cause of firms? licensing out behavior being stifled.However, this aspect has been scarcely studied empirically. We draw on rent dissipation arguments, and hypothesize that firms suffering from the not-invented-here (NIH) syndrome...

  14. Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.

    Science.gov (United States)

    Watson, Kimberly A; Chrysina, Evangelia D; Tsitsanou, Katerina E; Zographos, Spyros E; Archontis, Georgios; Fleet, George W J; Oikonomakos, Nikos G

    2005-12-01

    Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. Spirohydantoin of glucopyranose and N-acetyl-beta-D-glucopyranosylamine have been identified as the most potent inhibitors of GP that bind at the catalytic site. Four spirohydantoin and three beta-D-glucopyranosylamine analogs have been designed, synthesized and tested for inhibition of GP in kinetic experiments. Depending on the functional group introduced, the K(i) values varied from 16.5 microM to 1200 microM. In order to rationalize the kinetic results, we determined the crystal structures of the analogs in complex with GP. All the inhibitors bound at the catalytic site of the enzyme, by making direct and water-mediated hydrogen bonds with the protein and by inducing minor movements of the side chains of Asp283 and Asn284, of the 280s loop that blocks access of the substrate glycogen to the catalytic site, and changes in the water structure in the vicinity of the site. The differences observed in the Ki values of the analogs can be interpreted in terms of variations in hydrogen bonding and van der Waals interactions, desolvation effects, ligand conformational entropy, and displacement of water molecules on ligand binding to the catalytic site. PMID:16222658

  15. Study of a conceptual nuclear energy center at Green River, Utah: licensing considerations

    International Nuclear Information System (INIS)

    This report examines the laws governing the location of a 9-unit nuclear energy center (NEC) near Green River, Utah. The time frame being considered for development of the conceptual NEC is from 1995 to 2013. Accordingly, the report is forced to speculate about some aspects of the plant, its site and its construction. Most of the report examines existing legal requirements for constructing an NEC. Where pertinent, changes in the law are discussed that would affect an NEC that is to be licensed in one or two decades. In general, no insurmountable legal problems exist that would prevent an NEC from being licensed at the Green River location. Several legal requirements pose significant concerns and would have to be faced before an NEC could be built. Among the major legal constraints are radiation protection, regulatory approval of financing, access to water, and local zoning restrictions. Two other constraints that involve legal matters are the wisdom of standardization of the units and the responsibility of the NEC builder to correct socio-economic impacts on the local area

  16. A Simulation Study to Explore Configuring the New SAT® Critical Reading Section without Analogy Items. Research Report No. 2004-2. ETS RR-04-01

    Science.gov (United States)

    Liu, Jinghua; Feigenbaum, Miriam; Cook, Linda

    2004-01-01

    This study explored possible configurations of the new SAT® critical reading section without analogy items. The item pool contained items from SAT verbal (SAT-V) sections of 14 previously administered SAT tests, calibrated using the three-parameter logistic IRT model. Multiple versions of several prototypes that do not contain analogy items were…

  17. Experience in Application of Uncertainty Methods, Participation in Uncertainty Methods Study and Review of Methods Used in Licensing

    International Nuclear Information System (INIS)

    The paper covered the following topics: - application of uncertainty evaluation methods in Germany, - conclusions of the 'Uncertainty Methods Study', - short overview on the international situation in licensing, - further support development in GRS, future co-operation with FZK. The following conclusions had been drawn from the performed uncertainty analyses: - there were high requirements in determining uncertain input parameters: selection of suitable experimental and analytical information to determine ranges and probability distributions, and transfer of measured data into these ranges and distributions, - determination of ranges of calculation results were recommended for codes developed at GRS and important accident scenarios, - uncertainty importance ranking guides were leading to improvement of knowledge and effective code improvements. Recommendations had also been made with respect to the Uncertainty Method Study (UMS): - collection, qualification, review and dissemination of uncertainty data should be made more systematic, - code manuals should include relevant uncertainty information, - more efforts should be made to transform data measured in experiments and compared with posttest calculations into model parameters with uncertainties, - uncertainty analysis should be performed if useful conclusions are to be obtained from Best Estimate codes, - new generations of codes should provide 'internal assessment of uncertainty', - information gained in the UMS should be used to inform decisions on the conduct of uncertainty analyses, for example in the light of licensing requirements

  18. Licensing and Business Models

    OpenAIRE

    Onetti Alberto; Verma Sameer

    2008-01-01

    License affects software companies’ business activities. While proprietary software vendors create custom licenses, open source companies have less flexibility. The Open Source Initiative (OSI) defines a list of 72 licenses as open source (“OSI approved”). For a project to follow open source licensing, it has to pick licenses from this set. Logically, we expect that an open source company defines its business model around the license that it selects. Thus, we can assume that business model de...

  19. Nursing: Licensed Practical and Licensed Vocational Nurses

    Science.gov (United States)

    ... LPNs) and licensed vocational nurses (LVNs) provide basic nursing care. They work under the direction of registered ... licensed vocational nurses work in many settings, including nursing homes and extended care facilities, hospitals, physicians’ offices, ...

  20. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  1. The Monticello license renewal project

    International Nuclear Information System (INIS)

    Today, 111 nuclear power plants provide over 20 percent of the electrical energy generated in the United States. The operating license of the oldest operating plant will expire in 2003, one-third of the existing operating licenses will expire by 2010 and the newest plant's operating license will expire in 2033. The National Energy Strategy (NES) prepared by the Department of Energy (DOE) assumes that 70 percent of the current operating plants will continue to operate beyond their current license expiration. Power from current operating plants can assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth and improved U.S. competitiveness. In order to preserve this energy resource, three major tasks must be successfully completed: (1) establishment of regulations, technical standards, and procedures for the preparation and review of License Renewal Applications (LRAs); (2) development of technical criteria and bases for monitoring, refurbishing or replacing plant equipment; and (3) demonstration of the regulatory process by a plant obtaining a renewed license. Since 1986, the DOE has been working with the nuclear industry and the Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of a nuclear power plant by renewing the operating license. The Monticello Lead Plant demonstration project was initiated in September 1988, following the Pilot Plant studies. This paper is primarily focused on the status and insights gained from the Northern States Power Company (NSP) Monticello Lead Plant demonstration project. The following information is included: (1) Current Status - Monticello License Renewal Application; (2) Economic Analysis; (3) License Renewal Regulatory Uncertainty Issues; (4) Key Decisions; (5) Management Structure; (6) Technical and Licensing Perspective; (7) NRC Interactions; (8) Summary

  2. Study of archaeological analogs for the validation of nuclear glass long-term behavior models

    International Nuclear Information System (INIS)

    Fractured archaeological glass blocks collected from a shipwreck discovered in the Mediterranean Sea near Embiez Island (Var) were investigated because of their morphological analogy with vitrified nuclear waste and of a known and stable environment. These glasses are fractured due to a fast cooling after they were melted (like nuclear glass) and have been altered for 1800 years in seawater. This work results in the development and the validation of a geochemical model able to simulate the alteration of a fractured archaeological glass block over 1800 years. The kinetics associated with the different mechanisms (interdiffusion and dissolution) and the thermodynamic parameters of the model were determined by leaching experiments. The model implemented in HYTEC software was used to simulate crack alteration over 1800 years. The consistency between simulated alteration thicknesses and measured data on glass blocks validate the capacity of the model to predict long-term alteration. This model is able to account for the results from the characterization of crack network and its state of alteration. The cracks in the border zone are the most altered due to a fast renewal of the leaching solution, whereas internal cracks are thin because of complex interactions between glass alteration and transport of elements in solution (influence of initial crack aperture and of the crack sealing). The lowest alteration thicknesses, as well as their variability, can be explained. The analog behavior of archaeological and nuclear glasses from leaching experiments makes possible the transposition of the model to nuclear glass in geological repository. (author)

  3. The 2012 Transit of Venus for Cytherean Atmospheric Studies and as an Exoplanet Analog

    Science.gov (United States)

    Pasachoff, Jay M.; Schneider, G.; Babcock, B. A.; Lu, M.; Reardon, K. P.; Widemann, T.; Tanga, P.; Dantowitz, R.; Willson, R.; Kopp, G.; Yurchyshyn, V.; Sterling, A.; Scherrer, P.; Schou, J.; Golub, L.; Reeves, K.

    2012-10-01

    We worked to assemble as complete a dataset as possible for the Cytherean atmosphere in collaboration with Venus Express in situ and to provide an analog of spectral and total irradiance exoplanet measurements. From Haleakala, the whole transit was visible in coronal skies; our B images showed the evolution of the visibility of Venus's atmosphere and of the black-drop effect, as part of the Venus Twilight Experiment's 9 coronagraphs distributed worldwide with BVRI. We imaged the Cytherean atmosphere over two minutes before first contact, with subarcsecond resolution, with the coronagraph and a separate refractor. The IBIS imaging spectrometer at Sacramento Peak Observatory at H-alpha and carbon-dioxide also provided us high-resolution imaging. The NST of Big Bear Solar Observatory also provided high-resolution vacuum observations of the Cytherean atmosphere and black drop evolution. Our liaison with UH's Mees Solar Observatory scientists provided magneto-optical imaging at calcium and potassium. Spaceborne observations included the Solar Dynamics Observatory's AIA and HMI, and the Solar Optical Telescope (SOT) and X-ray Telescope (XRT) on Hinode, and total-solar-irradiance measurements with ACRIMSAT and SORCE/TIM, to characterize the event as an exoplanet-transit analog. Our expedition was sponsored by the Committee for Research and Exploration/National Geographic Society. Some of the funds for the carbon-dioxide filter for IBIS were provided by NASA through AAS's Small Research Grant Program. We thank Rob Lucas, Aram Friedman, and Eric Pilger '82 for assistance with Haleakala observing, Rob Ratkowski of Haleakala Amateur Astronomers for assistance with equipment and with the site, Stan Truitt for the loan of his Paramount ME, and Steve Bisque/Software Bisque for TheSky X controller. We thank Joseph Gangestad '06 of Aerospace Corp., a veteran of our 2004 expedition, for assistance at Big Bear. We thank the Lockheed Martin Solar and Astrophysics Laboratory and

  4. Brand Licensing : Once you pop you can’t stop: When brand licensing goes too far

    OpenAIRE

    Dementev, Kirill; Lukyanchenko, Yuliya; Emilsson, Cecilia

    2011-01-01

    Purpose: The purpose of this study is to investigate consumer’s attitude towards licensed products in relation to the parent brand, with respect to perceived quality, likelihood to buy and associations’ transferability. Background: Brand licensing has become one of an increasingly popular ways of stretching a brand into new product categories to reach more consumers in new markets. Despite the fact that brand licensing is less risky than building a brand from scratch, the odds that licensed p...

  5. Using the Transient Electromagnetic (TEM) Method for Mapping Deep Groundwater Tables in Mars Analog Environments: a Baseline Field Study.

    Science.gov (United States)

    Jernsletten, J. A.

    2004-05-01

    INTRODUCTION: The purpose of this study is to explore the use of electromagnetic geophysical techniques for mapping deep groundwater tables in Mars analog environments. In order to provide a baseline for such studies, and to evaluate the appropriateness of the Transient Electro-Magnetic (TEM) method in mapping deep groundwater tables, a field study was carried out in an area in the desert approximatelt 30 miles southwest of Tucson Arizona. The field area was chosen for its convenient logistics and access to technical support, as well as for its appropriateness as a baseline Mars analog site. DISCUSSION: The surface conditions at the site are less than ideal if the main motivation is to look for analogs for surface working conditions on Mars, due to a fairly dense cover of cacti and thorny brush. However, in a situation like in the present study, where the subsurface analog is of more interest, vegetation cover is only a logistical issue. The subsurface in the field area is quite conductive, a result of its clay-rich soil, and this may at first thought seem to make it a less than ideal location for Mars analog studies. The contrary is the case, however: In having to deal with the very conductive environment at the field area location for this baseline study, it is ensured that results and conclusions drawn from this work regarding issues such as working in a conductive environment and achieving certain depths of investigation can indeed be applied to planning field studies elsewhere. Further, the study is also designed to observe the effects of powerline noise on electromagnetic data, again presenting a very-difficult case, and further aiding in building a baseline case that is overall appropriately more difficult than most field studies will be (in terms of achieving good signal-to-noise ratios and depths of investigation). The field survey consisted of 40 in-loop TEM stations, divided into 3 lines, for 4 line-km of data. The survey was carried out by a crew of one

  6. Near-infrared spectroscopy of lacustrine sediments in the Great Salt Lake Desert: An analog study for Martian paleolake basins

    Science.gov (United States)

    Lynch, Kennda L.; Horgan, Briony H.; Munakata-Marr, Junko; Hanley, Jennifer; Schneider, Robin J.; Rey, Kevin A.; Spear, John R.; Jackson, W. Andrew; Ritter, Scott M.

    2015-03-01

    The identification and characterization of aqueous minerals within ancient lacustrine environments on Mars are a high priority for determining the past habitability of the red planet. Terrestrial analog studies are useful both for understanding the mineralogy of lacustrine sediments, how the mineralogy varies with location in a lacustrine environment, and for validating the use of certain techniques such as visible-near-infrared (VNIR) spectroscopy. In this study, sediments from the Pilot Valley paleolake basin of the Great Salt Lake desert were characterized using VNIR as an analog for Martian paleolake basins. The spectra and subsequent interpretations were then compared to mineralogical characterization by ground truth methods, including X-ray diffraction, automated scanning electron microscopy, and several geochemical analysis techniques. In general, there is good agreement between VNIR and ground truth methods on the major classes of minerals present in the lake sediments and VNIR spectra can also easily discriminate between clay-dominated and salt-dominated lacustrine terrains within the paleolake basin. However, detection of more detailed mineralogy is difficult with VNIR spectra alone as some minerals can dominate the spectra even at very low abundances. At this site, the VNIR spectra are dominated by absorption bands that are most consistent with gypsum and smectites, though the ground truth methods reveal more diverse mineral assemblages that include a variety of sulfates, primary and secondary phyllosilicates, carbonates, and chlorides. This study provides insight into the limitations regarding the use of VNIR in characterizing complex mineral assemblages inherent in lacustrine settings.

  7. Simulation study for cloud detection with space lidars by use of analog detection photomultiplier tubes.

    Science.gov (United States)

    Liu, Zhaoyan; Sugimoto, Nobuo

    2002-03-20

    Output signal electrons from photomultiplier tubes (PMTs) have neither a Gaussian nor a Poisson distribution because of changes induced by multiplication when the number of input signal photons and dark electrons is fewer than approximately 100. Therefore the assumption of a Gaussian distribution of signal electrons cannot be used in simulations for space lidar observations with PMTs, for which the number of return signal photons is normally small. A theory is introduced for analog detection with PMTs that have Poisson-distributed secondary-electron emission at each dynode stage. The theory is validated by straightforward numerical simulations. It is shown that the multiplication in PMTs is a multiply stochastic Poisson process and that the distribution of output signal electrons can be interpreted basically as Neyman type A. Analysis by the threshold method of cloud detection with a space lidar shows considerable difference between a Gaussian approximation and the exact distribution. The result indicates that the threshold level must be optimized for the exact distribution. Return signals were simulated for a proposed space lidar, and cloud detection with the threshold method was demonstrated. PMID:11921806

  8. Jarosite occurrence in the Deccan Volcanic Province of Kachchh, western India: Spectroscopic studies on a Martian analog locality

    Science.gov (United States)

    Bhattacharya, Satadru; Mitra, Souvik; Gupta, Saibal; Jain, Nirmala; Chauhan, Prakash; Parthasarathy, G.; Ajai

    2016-03-01

    The sulfate mineral jarosite is considered a key indicator of hydrous, acidic, and oxidizing conditions on the surface of early Mars. Here we report an analog terrestrial locality hosting jarosite from Matanumadh, Kachchh, western India, using detailed spectroscopic studies on weathered basalts of the Deccan Volcanic Province and overlying tuffaceous shales and sandstones of the Matanumadh Formation. Hyperspectral data in the visible/near-infrared (350-2500 nm) to midinfrared (4000-400 cm-1) region of the electromagnetic spectrum and X-ray diffraction patterns have been acquired on samples collected from the field to detect and characterize the hydrous sulfate and phyllosilicate phases present at the studied site. Hydrous sulfates occur in association with Al-rich phyllosilicates (kaolinite) that overlie a zone of Fe/Mg smectites in altered basalts. Jarosite is found within both saprolitic clay horizons altered from the basalt and within variegated sandstone and shale/clay units overlying the saprolite; it mostly occurs as secondary veins with or without gypsum. Jarosite is also seen as coatings on kaolinite clasts of varying shapes and sizes within the tuffaceous variegated sandstone unit. We argue that the overall geological setting of the Matanumadh area, with this unusual mineral assemblage developing within altered basalts and in the overlying sedimentary sequence, mimics the geological environment of many of the identified jarosite localities on Mars and can be considered as a Martian analog from this perspective.

  9. A comparative study of diastereomeric complexes formed by a prochiral substrate and three structurally analogous chiral molecules on Pt(111)

    Science.gov (United States)

    Lemay, Jean-Christian; Dong, Yi; Groves, Michael N.; Demers-Carpentier, Vincent; Goubert, Guillaume; Lafleur-Lambert, Raphaël; Boukouvalas, John; Hammer, Bjørk; McBreen, Peter H.

    2016-04-01

    A comparative study of chemisorbed bimolecular diastereomeric complexes formed by three structurally analogous chiral modifiers and a prochiral substrate on Pt(111) was performed using scanning tunneling microscopy (STM) and density functional theory (DFT) methods. The experiments determine, subject to a number of assumptions, the abundant binding configurations and whether the complexed substrate is organized into pro-S or pro-R states. The overall prochiral ratio (pr) estimated in this manner may be compared in each case to literature values for the enantiomeric ratio (er) observed in catalysis experiments. The experiments were performed using ketopantolactone as the substrate and (R)-1-(1-naphthyl)ethylamine, (R)-N-Methyl-1-(1-naphthyl)ethylamine and (R)-1-naphthyl-1,2-ethanediol as the structurally analogous chiral modifiers. The STM measurements were performed at room temperature to better mimic conditions under which the catalytic studies reported in the literature were performed. The results are discussed in terms of the stereochemical effects of subtle modifications of the structure of the chiral modifier.

  10. Spectral Study of Water Tracks as an Analog for Recurring Slope Lineae

    Science.gov (United States)

    Ojha, L.; Wilhelm, M. B.; Wray, J. J.

    2013-01-01

    Liquid water is a key requirement for life on Earth, and serves as an important constraint on present day habitability on Mars. Recurring Slope Lineae (RSL) are a unique phenomenon on Mars that may be formed by brine seeps. Their morphological, seasonal and temporal characteristics support this hypothesis; however, spectral evidence has been lacking. Ojha et al., 2013 recently analyzed CRISM images from all confirmed RSL in the southern mid-latitudes and equatorial regions and found no spectro-scopic evidence for water. Instead, enhanced abun-dances or distinct grain sizes of both ferric and ferrous minerals are observed at most sites. The strength of these spectral signatures changes as a function of sea-son, possibly indicating removal of a fine-grained sur-face component during RSL flow, precipitation of fer-ric oxides, and/or wetting of the substrate. Water tracks (WT) have been suggested as a terrestrial analog for RSL by Levy et al., 2011. WT are defined as dark surface features that extend downslope in a linear or branching fashion, usually oriented along the steepest local gradient, in the Dry Valleys of Antarctica. They can be 1-3 m in width and can have lengths up to 2 km. They share many morphological and seasonal characteristics with RSL including active growth during summer seasons and fading during winter. Snowmelt, ground ice melt and deliquescence by hygroscopic salts have been suggested as possible formation mechanisms for water tracks. No spectral work to date has been reported for water tracks.

  11. Driving Performance among Bioptic Telescope Users with Low Vision Two Years after Obtaining Their Driver's License: A Quasi-Experimental Study

    Science.gov (United States)

    Vincent, Claude; Lachance, Jean-Paul; Deaudelin, Isabelle

    2012-01-01

    This study sought to compare road safety of new drivers with low vision who have followed a specific pilot bioptic training program with other groups of drivers all matched for age and driving experience. A quasi-experimental design was used two years after drivers obtained their license. Drivers were classified in the experimental group (n = 10,…

  12. Electric Response of Hydrogen Peroxide-doped Water Ices: an Analog Study for Positive Hole Currents in Rocks

    Science.gov (United States)

    Stockburger, C. C.; Keller, C. T.; Gray, A.; Sornette, J.; Udom, A.; Cruikshank, D. P.; Freund, F.

    2013-12-01

    Hydrogen peroxide-doped water ices can be viewed an analog system to igneous and high-grade metamorphic rocks, which invariably contain peroxy defects, typically Si-OO-Si, and generate positive hole charge carriers when subjected to stress. By preparing pure water ice and hydrogen peroxide-doped water ices, freezing them to -80°C, allows us to control the concentration of peroxy defects (here hydrogen peroxide molecules) and study the electrical response, when the ices are subjected to stress. Blocks of pure water ice and hydrogen peroxide-doped water ices, -80°C, were prepared. Two methods to activate peroxy bonds were used: (i) stressing one end of rectangular blocks in a hydraulic press, (ii) subjecting one part of a 2-chamber plastic tray to intense ultrasound to create a gradient of activated charge carriers. In the hydraulic press experiments the pure water ice samples produced vanishingly small currents except for occasional transients, mostly negative, during fracturing of the ice. By contrast, hydrogen peroxide-doped water ices led to significant currents, consistently positive, flowing down the stress gradients. Using ultrasound as an activation method avoids fracturing. Therefore the results are much 'cleaner', not contaminated by hard-to-control fracture-induced currents. The positive sign of the currents suggests defect electrons, generated by the break-up of peroxy bonds of hydrogen peroxide molecules embedded in the ice structure, analogous to positive hole charge carriers that are stress-activated in rocks.

  13. Structural diagenesis in Upper Carboniferous tight gas sandstones. Lessons learned from the Piesberg analog study

    Energy Technology Data Exchange (ETDEWEB)

    Steindorf, P.; Hoehne, M.; Becker, S.; Hilgers, C. [RWTH Aachen Univ. (Germany). Energy and Mineral Resources Group (EMR); Koehrer, B. [Wintershall Holding GmbH, Barnstorf (Germany)

    2013-08-01

    unconventional reservoir properties at a subseismic scale, considering both the alteration and evolution of pore space during diagenesis and the formation of structures. Combined with well-log and core data, uncertainties in 3D-reservoir modeling parameters and fluid migration pathways from seismic- to micro-scale of analogous subsurface tight gas reservoirs may be significantly reduced. (orig.)

  14. Archaeological and industrial analogous for radioactive waste storage : study of metallic archaeological pieces (Archeo-II). Final report (June 2002)

    International Nuclear Information System (INIS)

    Present research represents the extension of project called ARCHEO-I. The investigation consists in a study of archaeological analogous of iron and steel, which contributes to consolidate the knowledge about behaviour and safety for the steel container of deep geological repositories (AGP). For AGP, attained information from archaeometallurgy links to geochemical surroundings gives knowledge about container's behaviour that can be patterned in order to assure design's security. The possibility to obtain real data of steel behaviour during centuries and thousand years, at the most diverse geochemical surroundings, allows a greater reliability in models. The study of each archaeological piece has been realised giving attention to surrounding terrain, depicting in a particular way the geology of different grounds and joining the information with physical-chemical parameters of the terrain. (Author)

  15. State Licenses & Permits

    Data.gov (United States)

    Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

  16. NMR studies of abasic sites in DNA duplexes: deoxyadenosine stacks into the helix opposite the cyclic analog of 2-deoxyribose

    International Nuclear Information System (INIS)

    Proton and phosphorus NMR studies are reported for the complementary d(C-A-T-G-A-G-T-A-C) x d(G-T-A-C-F-C-A-T-G) nonanucleotide duplex (designated AP/sub F/ 9-mer duplex) which contains a stable abasic site analog, F, in the center of the helix. This oligodeoxynucleotide contains a modified tetrahydrofuran moiety, isosteric with 2-deoxyribofuranose, which serves as a structural analog of a natural apurinic/apyrimidinic site. Exchangeable and nonexchangeable base and sugar protons, including those located at the abasic site, have been assigned in the complementary AP/sub F/ 9-mer duplex by recording and analyzing two-dimensional phase-sensitive NOESY data sets in H2O and D2O solution at low temperature (00C). These studies indicate that A5 inserts into the helix opposite the abasic site F14 and stacks with flanking G4 x C15 and G6 x C13 Watson-Crick base pairs. Base-sugar proton NOE connectivities were measured through G4-A5-G6 on the unmodified strand and between the base protons of C15 and the sugar protons of the 5'-flanking residue F14 on the modified strand. These studies establish that all glycosidic torsion angles are anti and that the helix is right-handed at and adjacent to the abasic site in the AP/sub F/ 9-mer duplex. Two of the 16 phosphodiester groups exhibit phosphorus resonances outside the normal spectral dispersion indicative of altered torsion angles at two of the phosphate groups in the backbone of the AP/sub F/ 9-mer duplex

  17. Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.

    Science.gov (United States)

    Dolot, Rafał; Kaczmarek, Renata; Sęda, Aleksandra; Krakowiak, Agnieszka; Baraniak, Janina; Nawrot, Barbara

    2016-06-01

    Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine triad proteins superfamily. HINT1 plays an important role in various biological processes, and it has been found in many species. Here, we report the first structure (at a 2.34Å resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide, containing bis-phosphorothioated glycerol mimicking a polyphosphate chain, obtained from a primitive monoclinic space group P21 crystal. In addition, the apo form of hHINT1 at the space group P21 refined to 1.92Å is reported for comparative studies. PMID:26905466

  18. Nuclear power stations licensing

    International Nuclear Information System (INIS)

    The judicial aspects of nuclear stations licensing are presented. The licensing systems of the United States, Spain, France and Federal Republic of Germany are focused. The decree n0 60.824 from July 7 sup(th), 1967 and the following legislation which define the systematic and area of competence in nuclear stations licensing are analysed

  19. Workshop on the role of natural analogs in geologic disposal of high-level nuclear waste: Proceedings

    International Nuclear Information System (INIS)

    A Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste was held in San Antonio, Texas on July 22--25, 1991. The proceedings comprise seventeen papers submitted by participants at the workshop. A series of papers addresses the relation of natural analog studies to the regulation, performance assessment, and licensing of a geologic repository. Applications of reasoning by analogy are illustrated in papers on the role of natural analogs in studies of earthquakes, petroleum, and mineral exploration. A summary is provided of a recently completed, internationally coordinated natural analog study at Pocos de Caldas, Brazil. Papers also cover problems and applications of natural analog studies in four technical areas of nuclear waste management-. waste form and waste package, near-field processes and environment, far-field processes and environment, and volcanism and tectonics. Summaries of working group deliberations in these four technical areas provide reviews and proposals for natural analog applications. Individual papers have been cataloged separately

  20. Workshop on the role of natural analogs in geologic disposal of high-level nuclear waste: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, L.A. [ed.] [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Murphy, W.M. [ed.] [Southwest Research Inst., San Antonio, TX (United States). Center for Nuclear Waste Regulatory Analyses

    1995-09-01

    A Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste was held in San Antonio, Texas on July 22--25, 1991. The proceedings comprise seventeen papers submitted by participants at the workshop. A series of papers addresses the relation of natural analog studies to the regulation, performance assessment, and licensing of a geologic repository. Applications of reasoning by analogy are illustrated in papers on the role of natural analogs in studies of earthquakes, petroleum, and mineral exploration. A summary is provided of a recently completed, internationally coordinated natural analog study at Pocos de Caldas, Brazil. Papers also cover problems and applications of natural analog studies in four technical areas of nuclear waste management-. waste form and waste package, near-field processes and environment, far-field processes and environment, and volcanism and tectonics. Summaries of working group deliberations in these four technical areas provide reviews and proposals for natural analog applications. Individual papers have been cataloged separately.

  1. Radar Sounding of Temperate Permafrost (Fairbanks, AK): Study of Dielectric and Scattering Losses in Mars-Analog Environment

    Science.gov (United States)

    Boisson, J.; Heggy, E.; Clifford, S. M.; Anglade, A.; Yoshikawa, K.

    2009-12-01

    Subsurface water on Mars has been subject to several hypothesis and debates. To access its potential distribution and state in the fractured Martian subsurface, two low-frequency radar sounders (MARSIS and SHARAD) are currently probing the Martian upper crust exploring dielectric evidence of volatiles presence. The identification of volatiles signatures using low frequency radars is constrained by our understanding of both dielectric and scattering losses mechanisms that are generated by the dielectric complexity and the heterogeneities of the Martian subsurface. Both of those parameters remain unfortunately poorly quantified in planetary analog environments. To address this issue, we conducted wide-band ground penetrating radar (GPR) investigations and resistivity survey on a permafrost terrain, at the Vault Creek located 21 km North of Fairbanks (Alaska, USA). The site presents a 40 m deep mining tunnel, which allows validating the subsurface composition and the different geologic interfaces as inferred from the radar echoes. The area shows several geomorphological and geophysical analogies to recently observed terrains in the high and mid-latitudes on Mars (e.g. permafrost, ground polygons and pingoos). The GPR surveys were performed at four central frequencies (40, 270, 400 and 900 MHz) along the same profile in order to monitor the attenuation mechanisms over the 40 to 900 MHz frequency band. The obtained data set provided an insight into characterizing and quantifying the different frequency-dependant loss mechanisms (mainly scattering and dielectric attenuation) that occur on the radar signal in permafrost. Scattering was found to dominate the overall observed attenuation starting 100 MHz and increased with frequency. Preliminary results suggest that the scattering losses are of 0.58dB/m at 270MHz compared to 0.80dB/m at 900MHz. Dielectric losses showed less frequency dependence than the scattering ones. The output of this study aims to constrain the

  2. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes

  3. Licensing to Market with Logit Demand Functions

    Institute of Scientific and Technical Information of China (English)

    YAN Qing-you; ZHU Li-li

    2009-01-01

    This paper studies the licensing of a brand innovation to a monopoly in an uncovered market characterized by a logit demand framework. The innovator is an outsider to the market and sells the license via fixed-fee, royalty or their combinations. It is shown that the license occurs irrespective of whether the utility of the new brand is improved or not, and that the optimal licensing policy for the innovator is fixed-fee only. Ultimately, the monopoly produces both the old and the new brand products, even in the case of utility-improving brand innovation. In addition, the incentive for the innovator was examined.

  4. The "Goldberg Variations" and Ian McEwan's Saturday - a study of interdisciplinary analogies

    OpenAIRE

    Lykka, Inga Hild

    2014-01-01

    This thesis examines the musical influence on Ian McEwan’s fiction, in particular that of the Goldberg Variations’ influence on his novel Saturday. This involves an interdisciplinary analysis that compares the two arts, and sheds light on both possibilities and difficulties with regards to which musical features are likely to occur in literature or not. The analysis is founded on previous interdisciplinary studies of music and literature in general, studies of representations of the Goldberg ...

  5. Analog and VLSI circuits

    CERN Document Server

    Chen, Wai-Kai

    2009-01-01

    Featuring hundreds of illustrations and references, this book provides the information on analog and VLSI circuits. It focuses on analog integrated circuits, presenting the knowledge on monolithic device models, analog circuit cells, high performance analog circuits, RF communication circuits, and PLL circuits.

  6. Study of eddy-initiated cavitation; cavitation in a venturi: analogy between water and sodium

    International Nuclear Information System (INIS)

    The test facilities and experimental research techniques are described: sodium loop, water loop, visualization of cavitation in water behind openings, cavitation detection. A theoretical study is then devoted to cavitation through separate bubbles, with special emphasis on flow in a venturi of gradually changing profile, and the relative motion of a cavitation bubble; a coherent model of equations describing the evolution of an isolated spherical bubble is given. A theoretical study of eddy-initiated cavitation is also presented. Finally the results of cavitation experiments carried out on the venturi line are given for sodium (at 5500, 4500, 2500) and water (at 160, 370, 570 and 700C)

  7. NMR study of the alpha cyclodextrin with a phospholipid analog dioctanoyl glycerol

    International Nuclear Information System (INIS)

    The molecular association of dioctanoyl glycerol (DOG) with the natural alpha cyclodextrin molecule (ACD) was studied using small unilamellar vesicles (SUV) by proton and 13CNMR. While no classic inclusion complex was found, a molecular association exists, leading to the formation of an insoluble precipitate. The possibility of a polar head group implication is discussed about the dimyristoyl phosphatidyl choline model. (authors). 4 refs., 4 figs

  8. Orbital and Ground-penetrating Radar Studies of Mars-analog Terrain in Egypt

    Science.gov (United States)

    Maxwell, T. A.; Grant, J. A.; Campbell, B. A.

    2007-05-01

    Several study groups have endorsed the concept of flying an imaging synthetic aperture radar (SAR) in orbit that would penetrate areas of thin surface cover revealing underlying terrain and providing additional information on surface roughness, physical properties and composition. Egypt provides many excellent terrestrial field sites to study both the processes that we expect to be revealed in a Mars SAR Mission, as well as the stratigraphic setting of past depositional environments that are similar to those seen in southern Egypt. We have used terrestrial orbital radar data for southern Egypt, comparing geologic materials and boundaries mapped in the field and with visible wavelengths (from Landsat) to those discerned via Shuttle Imaging Radar (SIR) -C, and field checking key sites to determine the depth, physical characteristics and types of geologic boundaries that contribute to the radar returns. In addition to stratigraphic mapping of the thickness and extent of near-surface units in the field, we have used ground-penetrating radar (GPR) to determine the lateral extent and depth of subsurface interfaces. In this manner, we expect to learn more about the capabilities and limitations of orbital and ground-based systems, the trade-offs between frequency, polarization and resolution in Mars-like terrain for detecting buried interfaces and structures, and more about the geologic history of southern Egypt. Several studies have concentrated on one of the areas of prominent radar-detected channels near Bir Safsaf in the southwest desert, we have concentrated on the Bir Kiseiba region, an area where the mixture of gravel spreads, buried paleochannels, and alluvium creates a setting that may mimic outflow deposit locations on Mars. While bedrock incised channels may stand out in SAR images because of a near-surface, sharp dielectric interface (such as those at Safsaf and in northern Sudan), the more complex problem of distinguishing fluvial patterns in Mars

  9. An Analog Study of First Language Dominance and Interference over Second Language

    OpenAIRE

    Houmanfar, Ramona; Hayes, Linda J.; Herbst, Scott A

    2005-01-01

    The purpose of this study was to design a model for “first language” dominance over “second language” performance and the interference of one language over the other. Two sets of equivalence relations showing a common element (i.e., the reference) were established under different contextual conditions. One set (“first language”) was over trained relative to the other (“second language”). Dominance of the “first language,” as demonstrated in relations involving the common element, was determin...

  10. Terrestrial Spaceflight Analogs: Antarctica

    Science.gov (United States)

    Crucian, Brian

    2013-01-01

    Alterations in immune cell distribution and function, circadian misalignment, stress and latent viral reactivation appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to those observed in Astronauts, either during or immediately following spaceflight. Others are unique to the Concordia analog. Based on some initial immune data and environmental conditions, Concordia winterover may be an appropriate analog for some flight-associated immune system changes and mission stress effects. An ongoing smaller control study at Neumayer III will address the influence of the hypoxic variable. Changes were observed in the peripheral blood leukocyte distribution consistent with immune mobilization, and similar to those observed during spaceflight. Alterations in cytokine production profiles were observed during winterover that are distinct from those observed during spaceflight, but potentially consistent with those observed during persistent hypobaric hypoxia. The reactivation of latent herpesviruses was observed during overwinter/isolation, that is consistently associated with dysregulation in immune function.

  11. A DFT/AB INITIO STUDY OF HYDROGEN BONDING AND CONFORMATIONAL PREFERENCE IN MODEL CELLOBIOSE ANALOGS USING B3LYP/6-311++G**

    Science.gov (United States)

    A series of beta-D-cellobiose analogs were studied at the B3LYP/6-311++G** level of theory to isolate and understand how the various electronic components of the beta-(1->4)-linked disaccharide, cellobiose, contribute to the energetic stability of the molecule in vacuo. Previous studies on beta-D-c...

  12. Science Teachers' Analogical Reasoning

    Science.gov (United States)

    Mozzer, Nilmara Braga; Justi, Rosária

    2013-08-01

    Analogies can play a relevant role in students' learning. However, for the effective use of analogies, teachers should not only have a well-prepared repertoire of validated analogies, which could serve as bridges between the students' prior knowledge and the scientific knowledge they desire them to understand, but also know how to introduce analogies in their lessons. Both aspects have been discussed in the literature in the last few decades. However, almost nothing is known about how teachers draw their own analogies for instructional purposes or, in other words, about how they reason analogically when planning and conducting teaching. This is the focus of this paper. Six secondary teachers were individually interviewed; the aim was to characterize how they perform each of the analogical reasoning subprocesses, as well as to identify their views on analogies and their use in science teaching. The results were analyzed by considering elements of both theories about analogical reasoning: the structural mapping proposed by Gentner and the analogical mechanism described by Vosniadou. A comprehensive discussion of our results makes it evident that teachers' content knowledge on scientific topics and on analogies as well as their pedagogical content knowledge on the use of analogies influence all their analogical reasoning subprocesses. Our results also point to the need for improving teachers' knowledge about analogies and their ability to perform analogical reasoning.

  13. Study of the electron transfer in analog compounds of the Prussia blue

    International Nuclear Information System (INIS)

    As answer to the necessity of the search of new nano structured materials, the present work was carried out that it studies the electron transfer in compound similar of the Prussia blue (CAAP), which are representative molecular materials, because its chromophore, magnetic, and electric properties, depend mainly on the processes that are made in their levels or orbital energy. It is known that these made up with octahedra symmetry that its are presented in form of powders, suffer processes of electron transfer when its are exposed to external stimulation by means of light (embracing the regions from the ultraviolet one until the infrared in the electromagnetic spectrum), because they are made up of mixed valency. To know that types of electronic transfers are those that are made in the study materials, 4 series of CAAP its were synthesized by the method of mixtures of aqueous solutions: M[Fe+3CN)6]2nH2O, M[Cr+3(CN)6]2nH2O, M[Mn+3(CN)6]3nH2O y M[Co+3(CN)6]3nH2O, and later on studied by means of the electron spectroscopy technique with a UV-SENSE spectrophotometer (Perkin-Elmer) in or n range of work of 250 to 1100 nm. Because to discuss the electronic structures of any compound, it is required the calculation of the energy levels, they took like reference the data tabulated by John Alexander and Harry Gray calculated by the modified theoretical approach of Wolfsberg-Helmhoz. When comparing the obtained spectra with the theoretical data, it was concludes that in the CAAP, its are carried out electronic transfers among orbital molecular metallic of the type d → d, and load transfer (TC) among orbital molecular of the ligand and metal. When being carried out a load transfer in the CAAP that initially are made up of under-spin these its are photoinduced to an excited state of high spin. In consequence it is possible to vary the interactions among the metals of transition of the CAAP and the ligands, allowing the extension of coordinated phenomena (as the magnetism

  14. Quality of sunglasses available in the Iranian market; a study with emphasis on sellers′ license

    Directory of Open Access Journals (Sweden)

    Nooshin Bazzazi

    2015-01-01

    Full Text Available Context: Sunglasses should follow minimum requirements to sufficiently protect eyes. It is not known whether all items obtainable from the market are appropriately designed. Aims: To compare ultraviolet (UV-protective properties of commercially available sunglasses obtained from authorized and unauthorized Iranian sellers. Settings and Study Design: An analytic-descriptive study performed in a metropolitan area (Tehran. Materials and Methods: Using a UV-visible standard spectrophotometer, the percentage transmittance was scanned between 280 and 400 nm in 348 pairs of nonprescription sunglasses (price range: 20-80 US$ obtained anonymously and randomly from authorized (permitted by the Ministry of Health, 189 pairs and unauthorized (159 pairs sellers in the Iranian capital city, Tehran. The Australian/New Zealand Standard (AS/NZS and the American National Standards Institute [ANSI] standards were followed. Statistical Analysis: Chi-square test, independent samples t-test or Mann-Whitney U-test. Results UV-protective properties of the sunglasses obtained from authorized sellers complied with AS/NZS and ANSI guidelines in 92.6% and 95.2% of items, respectively. The corresponding rates for sunglasses obtained from unauthorized sellers were 0% and 8.2%, respectively (P < 0.001 for both. The rate of defective polarizing capability of lenses was 27.4% in sunglasses obtained from authorized sellers versus 90.4% in sunglasses obtained from unauthorized sellers (P < 0.001. Neither brand nor price played significant contributions to UV protection/lens polarizing capability of sunglasses obtained from authorized sellers. Conclusions: Sunglasses provided by unauthorized sellers are alarmingly unreliable and could be potentially hazardous for the eye. Brand and price do not guarantee optimal protection against UV radiation or polarizing performance of the lens.

  15. Licensing of in situ leach recovery operations for the Crownpoint and Church Rock uranium deposits, New Mexico: A case study

    International Nuclear Information System (INIS)

    Licensing of in situ leach recovery operations in New Mexico, adjacent to the Navajo Indian Reservation, required significant effort on the part of Uranium Resources, Inc. and the subsidiary, Hydro Resources Inc., since the original application in 1988. On January 5, 1998, the U.S. Nuclear Regulatory Commission issued the license to operate following a lengthy Environmental Impact Statement process jointly managed by the U.S. Nuclear Regulatory Commission, the U.S. Bureau of Indian Affairs, and the U.S. Bureau of Land Management. The principal stakeholders include the State of New Mexico, the Navajo Nation and a number of citizen groups. The U.S. Environmental Protection Agency reviewed the Environmental Impact Statement. Since licensing, Hydro Resources Inc. overcame legal challenges to the source material license from groups opposed to uranium development and obtained the necessary water rights from the State of New Mexico on October 19, 1999. On January 19, 2000, the Navajo Nation lifted its 1983 moratorium on uranium mining for uranium in situ leach recovery. Since then, Hydro Resources Inc.'s focus has changed to preparing the Restoration Action Plan for Church Rock Section 17 site, Crownpoint Unit One, and Crownpoint. The U.S. Nuclear Regulatory Commission has since approved these plans. The Grants Uranium Region is located in northwestern New Mexico and is part of the Colorado Plateau physiographic province. The Jurassic Westwater Canyon Member of the Morrison Formation in the San Juan Basin hosts the uranium. The Crownpoint and Church Rock ore trends are monometallic, regional redox-controlled, roll-front type uranium deposits and occur as stacked roll-fronts. Other uranium deposits in the Grants Uranium Region include humate-type sandstone deposits including the Ambrosia Lakes District. Total low-cost Reasonably Assured Resources (RAR) for properties controlled by Hydro Resources Inc. includes 38,462 Tonnes U (100 million lbs U3O8). This paper reviews the

  16. Molecular modeling of fentanyl analogs

    Directory of Open Access Journals (Sweden)

    LJILJANA DOSEN-MICOVIC

    2004-11-01

    Full Text Available Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper.

  17. Trends in nuclear licensing

    International Nuclear Information System (INIS)

    The development of nuclear safety and licensing is briefly reviewed in four stages namely: The Formative Period (1946-1959), The Expansive Period (1960-1969), The Mature Period (1970-1979) and the Apprehensive Period (1980-1989). Particular safety issues in the respective periods are highlighted to indicate the changing emphasis of nuclear licensing over the past thirty years or so. Against this background, nuclear licensing. (author)

  18. Intuitive analog circuit design

    CERN Document Server

    Thompson, Marc

    2013-01-01

    Intuitive Analog Circuit Design outlines ways of thinking about analog circuits and systems that let you develop a feel for what a good, working analog circuit design should be. This book reflects author Marc Thompson's 30 years of experience designing analog and power electronics circuits and teaching graduate-level analog circuit design, and is the ideal reference for anyone who needs a straightforward introduction to the subject. In this book, Dr. Thompson describes intuitive and ""back-of-the-envelope"" techniques for designing and analyzing analog circuits, including transistor amplifi

  19. A comparison of acceptance- and control-based strategies for coping with food cravings: an analog study.

    Science.gov (United States)

    Forman, Evan M; Hoffman, Kimberly L; McGrath, Kathleen B; Herbert, James D; Brandsma, Lynn L; Lowe, Michael R

    2007-10-01

    The present study utilized an analog paradigm to investigate the effectiveness of two strategies for coping with food cravings, which was theorized to be critical to the maintenance of weight loss. Ninety-eight undergraduate students were given transparent boxes of chocolate Hershey's Kisses and instructed to keep the chocolates with them, but not to eat them, for 48 h. Before receiving the Kisses, participants were randomized to receive either (a) no intervention, (b) instruction in control-based coping strategies such as distraction and cognitive restructuring, or (c) instruction in acceptance-based strategies such as experiential acceptance and defusion techniques. Measures included the Power of Food Scale (PFS; a measure of psychological sensitivity to the food environment), self-report ratings of chocolate cravings and surreptitiously recorded chocolate consumption. Results suggested that the effect of the intervention depended on baseline PFS levels, such that acceptance-based strategies were associated with better outcomes (cravings, consumption) among those reporting the highest susceptibility to the presence of food, but greater cravings among those who scored lowest on the PFS. It was observed that craving self-report measures predicted chocolate consumption, and baseline PFS levels predicted both cravings and consumption. Results are discussed in terms of the implications for weight loss maintenance strategies. PMID:17544361

  20. Universal Licensing System (ULS)

    Data.gov (United States)

    Federal Communications Commission — The Universal Licensing System allows electronic filing of applications processed by the Commission. The ULS allows you to indicate the application purpose and...

  1. Licensing, supervision, retrofitting

    International Nuclear Information System (INIS)

    The lecture deals in detail with questions on the systematization and coordination of the elements the Atomic Energy Act defines as relevant to licensing; discretion to deny a licence for safety reasons - other licensing reservations under environmental law - protection of third parties - provisions for waste disposal and compliance with international obligations - protective aim of the law; questions on a concentrating effect in licensing and other administrative decisions; introduction of a plan approval procedure or site assessment and procedure; staged licensing procedure, dynamization of provisions against damage; subsequent obligations; introduction of periodical safety checks; abolition of the indemnification obligation pursuant to Paragraph 18 Section 3 of the Atomic Energy Act. (HSCH)

  2. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

  3. Study of effect of gate-length downscaling on the analog/RF performance and linearity investigation of InAs-based nanowire Tunnel FET

    Science.gov (United States)

    Biswal, Sudhansu Mohan; Baral, Biswajit; De, Debashis; Sarkar, Angsuman

    2016-03-01

    In this paper, we present a simulation study to report the effect of gate-length downscaling on the analog/RF performance and linearity investigation of InAs-based nanowire (NW) Tunnel FET (TFET). The different RF/analog and linearity figure of merits such as gm, RO, gm*RO, fT, fmax, GBW and 1-dB compression point of a NW TFET are extracted and the influence of gate-length downscaling on these parameters is analyzed. The RF/analog performance parameters obtained from InAs TFET is compared with an InAs MOSFET of identical dimension. Results reveal that superior RF and Linearity performance was obtained with gate-length downscaling for both devices under consideration. However, advantages of achieving improved RF performance with gate-length downscaling diminishes in terms of poor analog performance with gate-length downscaling for both the devices. This clearly indicates a trade-off between the analog and RF performance of a down-scaled InAs-based NW TFET and MOSFET. The results reveal that InAs TFET provides better fT, fmax and linearity performance in the saturation region than its MOSFET counterpart. It provides a reasonable RO, gm*RO at lower values of gate-overdrive voltage as compared to the InAs MOSFET. Therefore, this paper concludes that InAs NW TFETs have enormous potential to be a promising contender to the conventional bulk MOSFETs for realization of future generation low-power analog/RF applications.

  4. Analogies in the microscopic behavior of superfluid and classical helium studied by neturon scattering [Analogieen in het microscopische gedrag van superfluid en klassiek helium

    OpenAIRE

    Crevecoeur, R.M.

    1996-01-01

    In this thesis we have presented the results of a neutron scattering study of the analogies in the microscopic behavior of superfluid and classical helium. Therefore we performed both neutron-diffraction experiments to study the structure and inelastic neutron scattering experiments to study the dynamics of semi-classical helium at temperatures 4 and 8 K. Furthermore, we performed inelastic neutron scattering experiments on superfluid helium to study the multi-excitations. As a spin-off from ...

  5. Data-mining to build a knowledge representation store for clinical decision support. Studies on curation and validation based on machine performance in multiple choice medical licensing examinations.

    Science.gov (United States)

    Robson, Barry; Boray, Srinidhi

    2016-06-01

    Extracting medical knowledge by structured data mining of many medical records and from unstructured data mining of natural language source text on the Internet will become increasingly important for clinical decision support. Output from these sources can be transformed into large numbers of elements of knowledge in a Knowledge Representation Store (KRS), here using the notation and to some extent the algebraic principles of the Q-UEL Web-based universal exchange and inference language described previously, rooted in Dirac notation from quantum mechanics and linguistic theory. In a KRS, semantic structures or statements about the world of interest to medicine are analogous to natural language sentences seen as formed from noun phrases separated by verbs, prepositions and other descriptions of relationships. A convenient method of testing and better curating these elements of knowledge is by having the computer use them to take the test of a multiple choice medical licensing examination. It is a venture which perhaps tells us almost as much about the reasoning of students and examiners as it does about the requirements for Artificial Intelligence as employed in clinical decision making. It emphasizes the role of context and of contextual probabilities as opposed to the more familiar intrinsic probabilities, and of a preliminary form of logic that we call presyllogistic reasoning. PMID:27089305

  6. PERSONAL ATTRIBUTES ASSOCIATED WITH SUCCESSFUL MANAGEMENT IN THE HOSPITALITY INDUSTRY – A PILOT STUDY IN LICENSED RETAIL OPERATIONS

    OpenAIRE

    Ineson, Elizabeth M.; Stone, Graham J.

    2010-01-01

    The research sought to identify key qualities associated with successful licensed retail managers, defined as effective, efficient and profitable operators. Through semi-structured in-depth interviews, managers’ views on success criteria, and problems associated with this type of employment, were elicited. The greatest assets were considered to be personal stability, mobility, good health and support from relatives/family. Physical and mental stamina, well-developed interpersonal skills, anti...

  7. Licensing aspects regarding the RBMN project

    International Nuclear Information System (INIS)

    The licensing process of a waste disposal facility is a complex and demanding undertaking. It proceeds in phases, starting with the site selection and ending many decades later, when the radionuclides decayed and no longer offer possible hazard. That is one of the reasons why the licensing process for the Brazilian repository for low and intermediate level radioactive waste (RBMN Project) is a challenge for all the technicians involved. Besides that, the only national experience associated to this subject arose after a radiological accident in the State of Goias, in 1987. Two different institutions are involved in this licensing process: IBAMA, for environmental licensing, and CNEN, for nuclear licensing. Both of them will evaluate the possible impacts caused by the waste disposal, so it is essential to avoid conflicts and duplications of activities. The RBMN project has different teams for each main activity, and one of them is the Licensing group. This team has been planning the licensing activities for the repository, studying the legal framework and estimating costs and execution time for each step. This paper presents the status of the licensing activities regarding to the RBMN project done by the CNEN staff. (author)

  8. 50 CFR 260.50 - Suspension or revocation of license of licensed sampler or licensed inspector.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Suspension or revocation of license of... Licensing of Samplers and Inspectors § 260.50 Suspension or revocation of license of licensed sampler or... or evidence that he may wish to offer as to why his license should not be suspended or revoked....

  9. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

  10. Analog and hybrid computing

    CERN Document Server

    Hyndman, D E

    2013-01-01

    Analog and Hybrid Computing focuses on the operations of analog and hybrid computers. The book first outlines the history of computing devices that influenced the creation of analog and digital computers. The types of problems to be solved on computers, computing systems, and digital computers are discussed. The text looks at the theory and operation of electronic analog computers, including linear and non-linear computing units and use of analog computers as operational amplifiers. The monograph examines the preparation of problems to be deciphered on computers. Flow diagrams, methods of ampl

  11. Multilateral Collaborations in Analog Research

    Science.gov (United States)

    Cromwell, R. l.

    2016-01-01

    International collaborations in studies utilizing ground-based space flight analogs are an effective means for answering research questions common to participating agencies. These collaborations bring together worldwide experts to solve important space research questions. By collaborating unnecessary duplication of science is reduced, and the efficiency of analog use is improved. These studies also share resources among agencies for cost effective solutions to study implementation. Recently, NASA has engaged in collaborations with international partners at a variety of analog sites. The NASA Human Exploration Research Analog (HERA) is currently hosting investigator studies from NASA and from the German Space Agency (DLR). These isolation studies will answer questions in the areas of team cohesion, sleep and circadian rhythms, and neurobehavioral correlates to function. Planning for the next HERA campaign is underway as proposal selections are being made from the International Life Sciences Research Announcement (ILSRA). Studies selected from the ILSRA will be conducted across 4 HERA missions in 2017. NASA is planning collaborative studies with DLR at the :envihab facility in Cologne, Germany. Investigations were recently selected to study the effects of 0.5% CO2 exposure over 30 days of bed rest. These studies will help to determine the fidelity of this ground-based analog for studying the visual impairment intracranial pressure syndrome. NASA is also planning a multilateral collaboration at :envihab with DLR and the European Space Agency (ESA) to examine artificial gravity as a countermeasure to mitigate the effects of 60 days of bed rest. NASA is also considering collaborations with the Russian Institute for Biomedical Problems (IBMP) in studies that will utilize their Ground-based Experimental Facility (NEK). The NEK is comprised of 4 interconnected modules and a Martian surface simulator. This isolation analog can support 3 -10 crew members for long duration

  12. Analysis of translated tropes: metaphors, similes & analogies in a case study of the English & Dutch translations of the Russian poet Alexander Galich

    OpenAIRE

    Rura, Lidia

    2010-01-01

    Since Even-Zohar and Toury introduced a target-culture approach in translation studies, research focus turned to the effect of the target text on the reader. Consequently, it is, among other things, important to study the translation of typical elements of literary texts and their potential effect. This paper concentrates on the translation of a certain types of tropes dealing with comparison: metaphors, similes & analogies. Three categories of these tropes were selected for this paper: (i) ...

  13. Sociological impacts of nuclear generating stations - summary report on the NRC post-licensing studies. Final report 1 Oct 78-4 Jan 82

    International Nuclear Information System (INIS)

    The Post-Licensing Studies had four objectives. The first was to identify the socioeconomic effects resulting from the construction and operation of each of twelve nuclear power stations. The socioeconomic variables examined included: economic, demographic, housing, government, public response, and social organization characteristics. The second objective was to determine the way in which the identified effects were evaluated by study area groups. The third objective was to identify the determinants of the project-related effects. This task required knowledge of what combination of site, project, or other determinants was responsible for the project-related effects and for the evaluation of the effects. The fourth objective was to make recommendations with respect to assessment methodologies that could best be used to project the socioeconomic effects of the construction and operation of proposed nuclear generating stations. The objectives of the Post-Licensing Studies are met by the twelve individual case studies and by the Summary Report. The case studies identified the nuclear power stations and describe the evaluation of the effects by area residents. The Summary Report describes the collective findings of the individual case studies, compares the findings across sites to identify possible determinants of the effects, and examines the implication of the findings for future siting decisions and for the methodology most appropriate for projective assessments

  14. Product Licenses Database Application

    CERN Document Server

    Tonkovikj, Petar

    2016-01-01

    The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

  15. Terrestrial Analog Field Investigations to Enable Science and Exploration Studies of Impacts and Volcanism on the Moon, NEAs, and Moons of Mars

    Science.gov (United States)

    Heldmann, Jennifer Lynne; Colaprete, Anthony; Cohen, Barbara; Elphic, Richard; Garry, William; Hodges, Kip; Hughes, Scott; Kim, Kyeon; Lim, Darlene; McKay, Chris; Osinski, Gordon R.; Petro, Noah; Sears, Derek; Squyres, Steve; Tornabene, Livio

    2013-01-01

    Terrestrial analog studies are a critical component for furthering our understanding of geologic processes on the Moon, near-Earth asteroids (NEAs), and the moons of Mars. Carefully chosen analog sites provide a unique natural laboratory with high relevance to the associated science on these solar system target bodies. Volcanism and impact cratering are fundamental processes on the Moon, NEAs, and Phobos and Deimos. The terrestrial volcanic and impact records remain invaluable for our understanding of these processes throughout our solar system, since these are our primary source of firsthand knowledge on volcanic landform formation and modification as well as the three-dimensional structural and lithological character of impact craters. Regarding impact cratering, terrestrial fieldwork can help us to understand the origin and emplacement of impactites, the history of impact bombardment in the inner Solar System, the formation of complex impact craters, and the effects of shock on planetary materials. Volcanism is another dominant geologic process that has significantly shaped the surface of planetary bodies and many asteroids. Through terrestrial field investigations we can study the processes, geomorphic features and rock types related to fissure eruptions, volcanic constructs, lava tubes, flows and pyroclastic deposits. Also, terrestrial analog studies have the advantage of enabling simultaneous robotic and/or human exploration testing in a low cost, low risk, high fidelity environment to test technologies and concepts of operations for future missions to the target bodies. Of particular interest is the importance and role of robotic precursor missions prior to human operations for which there is little to no actual mission experience to draw upon. Also critical to understanding new worlds is sample return, and analog studies enable us to develop the appropriate procedures for collecting samples in a manner that will best achieve the science objectives.

  16. Using a water tank analogy to transform students’ intuitive knowledge of dynamic systems. A qualitative study of the case of motion

    OpenAIRE

    Saldarriaga, Maria

    2011-01-01

    This dissertation is a study of the effects of a water tank analogy on students’ intuitive knowledge of basic dynamic systems of motion. Prior research from science education shows that student understandings of science concepts and phenomena are frequently at odds with scientific laws and principles. Students bring to formal instruction a repertoire of intuitive knowledge of the physical world that they develop through their interpretation and assimilation of daily life experi...

  17. Analogy-Enhanced Instruction: Effects on Reasoning Skills in Science

    Science.gov (United States)

    Remigio, Krisette B.; Yangco, Rosanelia T.; Espinosa, Allen A.

    2014-01-01

    The study examined the reasoning skills of first year high school students after learning general science concepts through analogies. Two intact heterogeneous sections were randomly assigned to Analogy-Enhanced Instruction (AEI) group and Non Analogy-Enhanced (NAEI) group. Various analogies were incorporated in the lessons of the AEI group for…

  18. Allegheny County Dog Licenses

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — A list of dog license dates, dog breeds, and dog name by zip code. Currently this dataset does not include City of Pittsburgh dogs.

  19. The Analogical Mind

    OpenAIRE

    Holyoak, Keith J.; Thagard, P.

    1997-01-01

    We examine the use of analogy in human thinking from the perspective of a multiconstraint theory, which postulates three basic types of constraints: similarity, structure and purpose. The operation of these constraints is apparent in both laboratory experiments on analogy and in naturalistic settings, including politics, psychotherapy, and scientific research. We sketch how the multiconstraint theory can be implemented in detailed computational simulations of the analogical human mind.

  20. Analog circuit design

    CERN Document Server

    Dobkin, Bob

    2012-01-01

    Analog circuit and system design today is more essential than ever before. With the growth of digital systems, wireless communications, complex industrial and automotive systems, designers are being challenged to develop sophisticated analog solutions. This comprehensive source book of circuit design solutions aids engineers with elegant and practical design techniques that focus on common analog challenges. The book's in-depth application examples provide insight into circuit design and application solutions that you can apply in today's demanding designs. <

  1. Nuclear facilities licensing

    International Nuclear Information System (INIS)

    The need for the adoption of a legal and normative system, defining objectives, pescriptions and the process of nuclear licensing and building of nuclear power plants in Brazil is enphasized. General rules for the development of this system are presented. The Brazilian rules on the matter are discussed. A general view of the German legal system for nuclear power plant licensing and the IAEA recommendations on the subject are finally presented. (A.L.S.L.)

  2. The ESA-NASA CHOICE Study: Winterover at Concordia Station, Interior Antarctica, A Potential Analog for Spaceflight-Associated Immune Dysregulation

    Science.gov (United States)

    Crucian, B. E.; Stowe, R. P.; Mehta, S. K.; Quiriarte, H.; Pierson, D L.; Sams, C. F.

    2010-01-01

    For ground-based space physiological research, the choice of terrestrial analog must carefully match the system of interest. Antarctica winter-over at the European Concordia Station is potentially a superior ground-analog for spaceflight-associated immune dysregulation (SAID). Concordia missions consist of prolonged durations in an extreme/dangerous environment, station-based habitation, isolation, disrupted circadian rhythms and international crews. The ESA-NASA CHOICE study assesses innate and adaptive immunity, viral reactivation and stress factors during Concordia winterover deployment. Initial data obtained from the first study deployment (2009 mission; 'n' of 6) will be presented, and logistical challenges regarding analog usage for biological studies will also be discussed. The total WBC increased, and alterations in some peripheral leukocyte populations were observed during winterover at Concordia Station. Percentages of lymphocytes and monocytes increased, and levels of senescent CD8+ T cells were increased during deployment. Transient increases in constitutively activated T cell subsets were observed, at mission time points associated with endemic disease outbreaks. T cell function (early blastogenesis response) was increased near the entry/exit deployment phases, and production of most measured cytokines increased during deployment. Salivary cortisol demonstrated high variability during winterover, but was generally increased. A 2-point circadian rhythm of cortisol measurement (morning/evening) was unaltered during winterover. Perceived stress was mildly elevated during winterover. Other measures, including in-vitro DTH assessment, viral specific T cell number/function and latent herpesvirus reactivation have not yet been completed for the 2009 winterover subjects. Based on the preliminary data, alterations in immune cell distribution and function appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to

  3. Investigation of 3′-debenzoyl-3′-(3-([124I]-iodobenzoyl))paclitaxel analog as a radio-tracer to study multidrug resistance in vivo

    International Nuclear Information System (INIS)

    A study was carried out to identify a suitable radioactive paclitaxel analog and to use it to investigate tumor multidrug resistance in vivo. 3′-Debenzoyl-3′-(3-([124I]-iodobenzoyl))paclitaxel was prepared by aromatic iodination of 3′-debenzoyl-3′-(3-trimethylstannylbenzoyl)paclitaxel. Uptake of the labeled paclitaxel analog in nude mice bearing tumor with the paclitaxel sensitive cancer cell lines MCF7 and MDA-435/LCC6(WT), and multidrug resistant cell lines NCI/ADR-RES and MDA-435/LCC6(MDR), was studied. There was no difference in drug level between the sensitive and resistant MDA-435/LCC6 tumors at 6 h post-injection. However, at 6 h, there was a significant increase in drug level for the MCF7 tumor as compared with the NCI/ADR-RES tumor, presumably due to increased drug retention. At 24 h, drug uptake/retention was significantly higher in both sensitive tumor cell lines as compared to their drug resistant counterparts. Pretreatment of mice with MDR transport modulators, Cyclosporine or tRA 96029, did not increase the level of labeled paclitaxel analog in the drug resistant MDA-435/LCC6(MDR) tumor. On the other hand, at 24 h Cyclosporine apparently increased analog level in the drug sensitive MDA-435/LCC6(WT) tumor, aiding drug imaging studies. - Highlights: ► 3′-Debenzoyl-3′-(3-iodobenzoyl)paclitaxel cytotoxicity was comparable to paclitaxel. ► 3′-Debenzoyl-3′-(3-([124I]-iodobenzoyl)paclitaxel was synthesized. ► Uptake of the drug was higher in sensitive tumor compared to the resistant tumor. ► The Pgp-modulators had a positive effect on drug-sensitive tumor. ► The sensitive tumor was visible in images obtained using micoPET.

  4. Analog synthetic biology.

    Science.gov (United States)

    Sarpeshkar, R

    2014-03-28

    We analyse the pros and cons of analog versus digital computation in living cells. Our analysis is based on fundamental laws of noise in gene and protein expression, which set limits on the energy, time, space, molecular count and part-count resources needed to compute at a given level of precision. We conclude that analog computation is significantly more efficient in its use of resources than deterministic digital computation even at relatively high levels of precision in the cell. Based on this analysis, we conclude that synthetic biology must use analog, collective analog, probabilistic and hybrid analog-digital computational approaches; otherwise, even relatively simple synthetic computations in cells such as addition will exceed energy and molecular-count budgets. We present schematics for efficiently representing analog DNA-protein computation in cells. Analog electronic flow in subthreshold transistors and analog molecular flux in chemical reactions obey Boltzmann exponential laws of thermodynamics and are described by astoundingly similar logarithmic electrochemical potentials. Therefore, cytomorphic circuits can help to map circuit designs between electronic and biochemical domains. We review recent work that uses positive-feedback linearization circuits to architect wide-dynamic-range logarithmic analog computation in Escherichia coli using three transcription factors, nearly two orders of magnitude more efficient in parts than prior digital implementations. PMID:24567476

  5. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes. Revision 7 was published in January 1993 and became effective in August 1993. Supplement 1 is being issued primarily to implement administrative changes to the requalification examination program resulting from the amendment to 10 CFR 55 that eliminated the requirement for every licensed operator to pass an NRC-conducted requalification examination as a condition for license renewal. The supplement does not substantially alter either the initial or requalification examination processes and will become effective 30 days after its publication is noticed in the Federal Register. The corporate notification letters issued after the effective date will provide facility licensees with at least 90 days notice that the examinations will be administered in accordance with the revised procedures

  6. 7 CFR 52.32 - Suspension or revocation of license of licensed sampler or licensed inspector.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Suspension or revocation of license of licensed... Inspection and Certification Licensing of Samplers and Inspectors § 52.32 Suspension or revocation of license..., with the Secretary supported by any argument or evidence that he may wish to offer as to why...

  7. Molecular analogs of the hemihelix: A computational study of chain molecules containing left- and right-handed helices

    Science.gov (United States)

    Pichierri, Fabio

    2014-08-01

    Using density functional theory (DFT) we design two novel chain molecules containing a left-handed (thia)helicene unit connected to a right-handed (thia)helicene unit via a phosphoroussbnd phosphorous (Psbnd P) bond. These chains represent the molecular analogs of the novel hemihelix structure recently discovered by a group of Harvard University scientists. The HOMO and LUMO levels of the heterochiral chains, termed hemihelicenes, are localized on the left- and right-handed blocks, respectively. In contrast, the frontier orbitals of the chains containing homochiral (thia)helicenes connected by a Psbnd P bond are delocalized all over the chain.

  8. Natural analogs in the host rock salt. Pt. 1. General study (2011). Pt. 2. Detail studies (2012-2013); Natuerliche Analoga im Wirtsgestein Salz. T. 1. Generelle Studie (2011). T. 2. Detailstudien (2012-2013)

    Energy Technology Data Exchange (ETDEWEB)

    Brasser, Thomas; Fahrenholz, Christine; Kull, Herbert; Meleshyn, Artur; Moenig, Heike; Noseck, Ulrich; Schoenwiese, Dagmar; Wolf, Jens

    2014-12-15

    The first part of the project ISIBELII on natural analogs in the host rock salt included a summary of available studies on the topic to be used in a safety analysis for a final repository for heat generating radioactive waste. In 2012 the results of the preliminary safety analysis Gorleben was available, including results on the fracturing of anhydrite, the formation of cryogenic gaps and the influence of earthquakes. The requirements for the barrier system have been modified due to the safety requirements for the final disposal of heat-generating radioactive wastes valid since 2010. For containers the functionality gas to be demonstrated for 500 years. The following issues are covered: natural analogs for the integrity demonstration of the geological barrier, natural analogs for the integrity demonstration of geotechnical barriers, natural analogs for the evaluation of release scenarios. The detail studies include anhydrite fracturing, salt grit compaction, chemical composition of fluid inclusions, thermal stability of salt rock, mechanical stability of salt rock, influence of earthquakes, qualified closures, iron corrosion, and microbial processes.

  9. Improving the Business Trade Licensing Reform Environment

    OpenAIRE

    Gamser, Matthew

    2003-01-01

    This case study of Kenyan business trade licensing shows that red-tape costs can be cut if reform is championed strongly and there is a strong case in terms of costs and benefits. The reform of business registration, trade licensing and other business entry procedures is a cost effective and progressive way to promote indigenous private sector development. But, reform needs more than good cost-benefit analysis and legal drafting; it also requires building constituencies and continuous advocacy.

  10. Hydraulic Capacitor Analogy

    Science.gov (United States)

    Baser, Mustafa

    2007-01-01

    Students have difficulties in physics because of the abstract nature of concepts and principles. One of the effective methods for overcoming students' difficulties is the use of analogies to visualize abstract concepts to promote conceptual understanding. According to Iding, analogies are consistent with the tenets of constructivist learning…

  11. Analog pulse processor

    Science.gov (United States)

    Wessendorf, Kurt O.; Kemper, Dale A.

    2003-06-03

    A very low power analog pulse processing system implemented as an ASIC useful for processing signals from radiation detectors, among other things. The system incorporates the functions of a charge sensitive amplifier, a shaping amplifier, a peak sample and hold circuit, and, optionally, an analog to digital converter and associated drivers.

  12. Analysis of analogies used by science teachers

    Science.gov (United States)

    Dagher, Zoubeida R.

    Science teachers use analogies that display a rich variety of form and content. An account of science teacher analogies that relies solely on systems of analysis imported from other fields of inquiry tends to obscure the unique features of these analogies as they operate within classroom discourse. This study examines teachers' analogies in context and highlights some of their special characteristics. The purpose of this analysis is to increase our understanding of how analogies operate in naturalistic instructional settings and to generate new research questions about science teaching and learning in view of the broader dimensions of the curriculum.Science isa very human activity. It involves human actors and judgements, rivalries and antagonisms, mysteries and surprises, the creative use of metaphor and analogy. It is fallible, often uncertain, and sometimes creatively ambiguous [Lemke, 1990, p. 134].Received: 1 June 1993; Revised: 29 November 1993;

  13. Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor

    Directory of Open Access Journals (Sweden)

    Chean Hui Ng

    2014-08-01

    Full Text Available The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides. The search for selective LOX inhibitors may provide new therapeutic approach for inflammatory diseases. Herein, we report the synthesis of tHGA analogs using simple Friedel-Craft acylation and alkylation reactions with the aim of obtaining a better insight into the structure-activity relationships of the compounds. All the synthesized analogs showed potent soybean 15-LOX inhibitory activity in a dose-dependent manner (IC50 = 10.31–27.61 μM where compound 3e was two-fold more active than tHGA. Molecular docking was then applied to reveal the important binding interactions of compound 3e in soybean 15-LOX binding site. The findings suggest that the presence of longer acyl bearing aliphatic chain (5Cs and aromatic groups could significantly affect the enzymatic activity.

  14. Analogical Processes and College Developmental Reading

    Science.gov (United States)

    Paulson, Eric J.

    2014-01-01

    Although a solid body of research concerning the role of analogies in reading processes has emerged at a variety of age groups and reading proficiencies, few of those studies have focused on analogy use by readers enrolled in college developmental reading courses. The current study explores whether 232 students enrolled in mandatory (by placement…

  15. GOVERNOR ORGANIZATIONS ACTIVITY LICENSING

    Directory of Open Access Journals (Sweden)

    Maslennikova L. V.

    2015-03-01

    Full Text Available The author analyses the licensing of governor organizations activity in connection with amendments to the Housing Code of the Russian Federation by adoption of a Federal law of 21.07.2014 N 255-FZ «On amendments to the Housing Code of the Russian Federation, some legislative acts of the Russian Federation and on declare force Certain Provisions of Legislative Acts of the Russian Federation void » and the Government Resolution adoption of the of 28.10.2014г. N 1110 «On entrepreneur activity in apartment buildings’ government licensing». The urgency of the issue of the apartment buildings licensing activity is associated with the modernization of housing and communal services and legal regulation in this area. Introduction of the governor organizations activity licensing without securing in law the concept of "governor organizations" is a significant flaw of the legislator. As a result, the author gives the concept of governor organizations based on the analysis of scientific papers and current legislation. In addition, the article analyzes the introduction of licensing control, assesses the established order of the three registers on the governor organizations activity. The presented paper examines the experience of foreign countries associated with the activities on the apartment building common property management as well, and the state control over such activity. The authors examine violations of housing legislation that may cause the governor organizations and their officials’ administrative responsibility

  16. Development of licensing process of nuclear power plants (NPPs) for Kenya

    Energy Technology Data Exchange (ETDEWEB)

    Shadrack, A. K. [Radiation Protection Board, Mombasa (Kenya)

    2012-03-15

    This research paper presents the findings of a comprehensive survey and analysis of the licensing procedures of six leading countries with nuclear power technology. The main objective of this study was to develop a generic reference licensing procedure of nuclear power plants for Kenya based on the best practices from the licensing procedures of six countries such as US, republic of Korea Canada, Japan, UK, France and Japan. Based on the analysis results, a generic reference licensing process for Kenya was developed and two future research areas significant for the establishment of nuclear regulation infrastructure for Kenya recommended. The analysis process classified the licensing process according to licensing stages, licensing steps, and levels of authorization. Finally, a two - step licensing procedures for Kenya was established comprising of 3 licensing stages, 3 licensing steps, and 3 levels of authorization. This research paper is useful as a draft for legislation process for nuclear power plants sitting, design, construction, commissioning, operation, and decommissioning in Kenya.

  17. Meat analog: a review.

    Science.gov (United States)

    Malav, O P; Talukder, S; Gokulakrishnan, P; Chand, S

    2015-01-01

    The health-conscious consumers are in search of nutritious and convenient food item which can be best suited in their busy life. The vegetarianism is the key for the search of such food which resembles the meat in respect of nutrition and sensory characters, but not of animal origin and contains vegetable or its modified form, this is the point when meat analog evolved out and gets shape. The consumers gets full satisfaction by consumption of meat analog due to its typical meaty texture, appearance and the flavor which are being imparted during the skilled production of meat analog. The supplement of protein in vegetarian diet through meat alike food can be fulfilled by incorporating protein-rich vegetative food grade materials in meat analog and by adopting proper technological process which can promote the proper fabrication of meat analog with acceptable meat like texture, appearance, flavor, etc. The easily available vegetables, cereals, and pulses in India have great advantages and prospects to be used in food products and it can improve the nutritional and functional characters of the food items. The various form and functional characters of food items are available world over and attracts the meat technologists and the food processors to bring some innovativeness in meat analog and its presentation and marketability so that the acceptability of meat analog can be overgrown by the consumers. PMID:24915320

  18. Nuclear licensing in Slovenia

    International Nuclear Information System (INIS)

    The article presents the approach to nuclear licensing in Slovenia. The paper describes, the initialization, internal authorization and review process in the Krsko NPP. The overall process includes preparation, internal independent evaluation, the Krsko Operating Committee and the Krsko Safety Committee review and internal approval. In addition, the continuation of the licensing process is discussed which includes independent evaluation by an authorized institution and a regulatory body approval process. This regulatory body approval process includes official hearing of the licensee, communication with the licensee, and final issuance of a license amendment. The internal evaluation, which follows the methodology of US NRC (defined in 10 CFR 50.59 and NUMARC 125) is described. This concept is partially implemented in domestic legislation.(author)

  19. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  20. BMU support in the licensing procedure concerning the decommissioning of the repository for radioactive waste Morsleben (ERAM). Studies and results

    International Nuclear Information System (INIS)

    To support the BMU in the licensing procedure concerning the decommissioning of the repository for radioactive waste Morsleben, GRS has derived requirements for the application and safety demonstration procedure as well as for the corresponding stages of work under nuclear as well as conventional engineering aspects. This report gives a survey of the current status of development of the definitive decommissioning concept, the requisite long-term safety case, and the planning status concerning the legal areas of conventional engineering touched by the plans put forward by the licensee. The comments on the characterisation under radiological and chemotoxic aspects of the materials emplaced and on the identification of the work necessary to establish the design conditions of the technical facilities until plan approval were updated in line with the development of the plans and the information provided. A comment was prepared on the latest technical plans concerning the premature backfilling of the central area of the Bartensleben mine. The reporting period covers the work carried out in the year 2001. (orig.)

  1. Troubleshooting analog circuits

    CERN Document Server

    Pease, Robert A

    1991-01-01

    Troubleshooting Analog Circuits is a guidebook for solving product or process related problems in analog circuits. The book also provides advice in selecting equipment, preventing problems, and general tips. The coverage of the book includes the philosophy of troubleshooting; the modes of failure of various components; and preventive measures. The text also deals with the active components of analog circuits, including diodes and rectifiers, optically coupled devices, solar cells, and batteries. The book will be of great use to both students and practitioners of electronics engineering. Other

  2. License to Learn

    DEFF Research Database (Denmark)

    Leone, Maria Isabella; Boccardelli, Paolo; Reichstein, Toke;

    2016-01-01

    . Licensees that are more familiar with the licensed technology are in less need of assistance from the licensors to assimilate and integrate the knowledge. However, this substitution effect is neutralized once the hurdle of invention has been overcome, meaning that the licensees have succeeded to ignite the......This article introduces the distinction between thin and thick contracts to the investigation of licensing-in as a mechanism for technological learning. Thick contracts include a clause specifying that the licensors are obligated to assist the licensees in assimilating and integrating the...

  3. Archaeological analogous and industrials for deep storage: study of the archaeological metallic piece; Analogos arqueologicos e industriales para almacenamientos profundos: estudio de piezas arqueologicas metalicas

    Energy Technology Data Exchange (ETDEWEB)

    Criado Portal, A. J.; Martinez Garcia, J. A.; Calabres Molina, R.; Garcia abajo, A.; Penco Valenzuela, F.; Lecanda Esteban, J. A.; Garcia Bartual, M.; Jimenez Gonzalez, J. M.; Bravo Munoz, E.; Rodriguez Lobo, L. M.; Fernandez Cascos, T.; Fernandes Cordero, O.; Montero Ruiz, I.

    2000-07-01

    The aim of present research is to obtain information about archaeological analogous of iron and steel, useful for the model of deep geological repository (AGP). The analogous examined have remained buried between 1400 and 2400 years, in very assorted geochemical environments. The extraction of the archaeological pieces has been accomplished according to normalised protocols, trying to carry to the laboratory so the piece as its burial environment, avoiding all possible pollution. Trying to the archaeological analogous could provide valuable information to the AGP model, the study has been directed to related the physical-chemical characteristics of the terrain respect to the deterioration of the archaeological metallic piece. The geology of the surrounding terrain to the archaeological deposit, the geomorphological study of the terrain and data from the analysis of ground: pH, wetness, porosity, organic matter contents, bacteria presence, sulphates, carbonates, chlorides, etc., have allowed to explain the physical-chemical phenomena suffered by the archaeological iron and steel pieces. Also, an exhaustive study of the archaeological piece has been accomplished, concerning the microstructure of the corrosion layer and of the not deteriorated metallic rest. Obtained information concerns different items, such as corrosion velocity and formations of oxide layers, diffusion of chemical elements from the corrosion layer to the metal and viceversa, and structural changes in oxide layers and in the metallic remains by structural ageing. Obtained data have allowed to develop a mathematical model for calculation of corrosion velocity in buried iron and steels, based on physical-chemical variables of grounds, chemical composition and thermomechanical treatment given to the metal during its manufacture. (Author)

  4. Young Children's Analogical Reasoning in Science Domains

    Science.gov (United States)

    Haglund, Jesper; Jeppsson, Fredrik; Andersson, Johanna

    2012-01-01

    This exploratory study in a classroom setting investigates first graders' (age 7-8 years, N = 25) ability to perform analogical reasoning and create their own analogies for two irreversible natural phenomena: mixing and heat transfer. We found that the children who contributed actively to a full-class discussion were consistently successful at…

  5. A Comparative study of Analog and digital Controller On DC/DC Buck-Boost Converter Four Switch for Mobile Device Applications

    Directory of Open Access Journals (Sweden)

    Benlafkih Abdessamad

    2013-01-01

    Full Text Available this paper presents comparative performance between Analog and digital controller on DC/DC buck-boost converter four switch. The design of power electronic converter circuit with the use of closed loop scheme needs modeling and then simulating the converter using the modeled equations. This can easily be done with the help of state equations and MATLAB/SIMULINK as a tool for simulation of those state equations. DC/DC Buckboost converter in this study is operated in buck (step-down and boost (step-up modes.

  6. A Comparative study of Analog and digital Controller On DC/DC Buck-Boost Converter Four Switch for Mobile Device Applications

    OpenAIRE

    Benlafkih Abdessamad; Krit Salah-Ddine; Chafik Elidrissi Mohamed

    2013-01-01

    this paper presents comparative performance between Analog and digital controller on DC/DC buck-boost converter four switch. The design of power electronic converter circuit with the use of closed loop scheme needs modeling and then simulating the converter using the modeled equations. This can easily be done with the help of state equations and MATLAB/SIMULINK as a tool for simulation of those state equations. DC/DC Buckboost converter in this study is operated in buck (step-down) and boost ...

  7. Challenges in Analogical Reasoning

    CERN Document Server

    Lin, Shih-Yin

    2016-01-01

    Learning physics requires understanding the applicability of fundamental principles in a variety of contexts that share deep features. One way to help students learn physics is via analogical reasoning. Students can be taught to make an analogy between situations that are more familiar or easier to understand and another situation where the same physics principle is involved but that is more difficult to handle. Here, we examine introductory physics students' ability to use analogies in solving problems involving Newton's second law. Students enrolled in an algebra-based introductory physics course were given a solved problem involving tension in a rope and were then asked to solve another problem for which the physics is very similar but involved a frictional force. They were asked to point out the similarities between the two problems and then use the analogy to solve the friction problem.

  8. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    The Operating Reactors Licensing Actions Summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors

  9. Analog circuits cookbook

    CERN Document Server

    Hickman, Ian

    2013-01-01

    Analog Circuits Cookbook presents articles about advanced circuit techniques, components and concepts, useful IC for analog signal processing in the audio range, direct digital synthesis, and ingenious video op-amp. The book also includes articles about amplitude measurements on RF signals, linear optical imager, power supplies and devices, and RF circuits and techniques. Professionals and students of electrical engineering will find the book informative and useful.

  10. Synthesis of Paclitaxel Analogs

    OpenAIRE

    Xu, Zhibing

    2010-01-01

    Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel analogs have been synthesized and their biological activities have been evaluated. In order to reduce the myelosuppression effect of the paclitaxel, several C3â ² and C4 paclitaxel analogs have been synth...

  11. Trends in CANDU licensing

    International Nuclear Information System (INIS)

    Modern utilities view nuclear power more and more as a commodity - it must compete 'today' with current alternatives to attract their investment. With its long construction times and large capital investment, nuclear plants are vulnerable to delays once they have been committed. There are two related issues. Where the purchaser and the regulator are experienced in CANDU, the thrust is a very practical one: to identify and resolve major licensing risks at a very early stage in the project. Thus for a Canadian project, the designer (AECL) and the prospective purchaser would deal directly with the AECB. However CANDU has also been successfully licensed in other countries, including Korea, Romania, Argentina, India and Pakistan. Each of these countries has its own regulatory agency responsible for licensing the plant. In addition, however, the foreign customer and regulator may seek input from the AECB, up to and including a statement of licensability in Canada; this is not normally needed for a ''repeat'' plant and/or if the customer is experienced in CANDU, but can be requested if the plant configuration has been modified significantly from an already-operating CANDU. It is thus the responsibility of the designer to initiate early discussions with the AECB so the foreign CANDU meets the expectations of its customers

  12. A License To Deal.

    Science.gov (United States)

    Sanville, Tom

    1999-01-01

    Discusses consortium-based licensing as a means of meeting libraries' information resources needs. Topics include information needs, the need for more affordable information, requirements for libraries and for vendors, competition across disciplines, saving money, pricing and market practices, experiences at OhioLINK, and future possibilities.…

  13. Electrical Circuits and Water Analogies

    Science.gov (United States)

    Smith, Frederick A.; Wilson, Jerry D.

    1974-01-01

    Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

  14. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis

  15. Folding model study of the isobaric analog excitation: isovector density dependence, Lane potential and nuclear symmetry energy

    CERN Document Server

    Khoa, Dao T; Cuong, Do Cong

    2007-01-01

    A consistent folding model analysis of the ($\\Delta S=0, \\Delta T=1$) charge exchange \\pn reaction measured with $^{48}$Ca, $^{90}$Zr, $^{120}$Sn and $^{208}$Pb targets at the proton energies of 35 and 45 MeV is done within a two-channel coupling formalism. The nuclear ground state densities given by the Hartree-Fock-Bogoljubov formalism and the density dependent CDM3Y6 interaction were used as inputs for the folding calculation of the nucleon optical potential and \\pn form factor. To have an accurate isospin dependence of the interaction, a complex isovector density dependence of the CDM3Y6 interaction has been carefully calibrated against the microscopic Brueckner-Hatree-Fock calculation by Jeukenne, Lejeune and Mahaux before being used as folding input. Since the isovector coupling was used to explicitly link the isovector part of the nucleon optical potential to the cross section of \\pn reaction exciting the 0$^+$ isobaric analog states in $^{48}$Sc, $^{90}$Nb, $^{120}$Sb and $^{208}$Bi, the newly paramet...

  16. Influence of Underlap on Gate Stack DG-MOSFET for analytical study of Analog/RF performance

    Science.gov (United States)

    Kundu, Atanu; Dasgupta, Arpan; Das, Rahul; Chakraborty, Shramana; Dutta, Arka; Sarkar, Chandan K.

    2016-06-01

    In this paper, the characteristics of 18 nm Underlap Double Gate (U-DG) NMOSFET with gate stack, (GS) are presented. The high-k dielectric as gate insulator under consideration is Hafnium Dioxide (HfO2). The SiO2 padding reduces the effect of scattering at the silicon and oxide interface. The ratio of on current to off current is used for optimizing the underlap length. The Analog and RF performance comparison are shown in this paper considering the drain current (Id), the transconductance (gm), the intrinsic gain (gmRo), the intrinsic capacitances (Cgs, Cgd), the intrinsic resistances (Rgs, Rgd), the transport delay (τm), the intrinsic inductance (Hsd), the unity current gain cut-off frequency (fT) and the maximum frequency of oscillation (fmax). RF parameters are extracted using the Non Quasi Static (NQS) model of the U-DG MOSFET. The performance of single stage amplifiers using the devices is also analyzed. The sharpest transition is shown in case of U-DG-GS MOSFET with optimized underlap length and enhancement in the intrinsic capacitances and resistances, and unity Gain Bandwidth product in case of devices with GS.

  17. Four Essays on Technology Licensing and Firm Innovation

    DEFF Research Database (Denmark)

    Moreira, Solon

    &D strategies. On the supply side, the existing literature has been focused on understanding how technology licensing can be used by firms as a mechanism to recover investments in innovative activities and to foster learning opportunities. On the demand side, it has been shown that licensing is an important...... source that firms can tap into to feed their internal needs for innovative knowledge. While several studies have examined technology licensing through the lens of the licensor, research on how firms rely on licensing contracts to acquire knowledge and improve their innovation performance still leaves...... much to be investigated. Furthermore, with few exceptions, neither organizational nor contractual characteristics related to the licensing deals have received enough attention as determinants of the capacity of the acquiring firm to benefit from licensing in a new technology. The purpose of this...

  18. Survey and Evaluation of Digital I and C Licensing Experiences

    International Nuclear Information System (INIS)

    Digital I and C licensing experiences showed significant performance variance among different cases, i.e., some were smooth and efficient while others were lengthy and problematic. In order to explain the causes of such variance and to develop more efficient licensing techniques, we conducted an in-depth survey and analysis of these licensing experiences. By viewing the licensing process as an evidence- confidence conversion process, a Licensing Performance Model has been developed and used as a framework to analyze the behavior characteristics of licensing activities. The model identified major factors and functions that dominate the performance of licensing process, among which the proficiency maturity and evidence profiles are the most critical factors that affect the licensing performance. During the evaluation step we were able to apply this model to explain why some previous licensing cases were successful and some were troublesome. This successful application shows the validity of the proposed model. Finally, we presented insights into the nature of licensing process gained form this study and recommended approaches for improving licensing performance. In this paper we reported the preliminary result of our survey and evaluation of major digital I and C licensing experiences accumulated in the recent years. The motivation is that we noticed the performance variance among different digital I and C licensing cases, i.e., some were smooth and efficient while others were lengthy and problematic. In order to explain the causes of such variance and to develop techniques for improving the effectiveness of licensing process, we conducted an in-depth survey and analysis of these experiences. By viewing the licensing process as a confidence conversion process, a Licensing Performance Model is developed and used as a framework to analyze the behavior characteristics of licensing activities. The model identified major factors and functions that dominate the performance

  19. Computational approaches to analogical reasoning current trends

    CERN Document Server

    Richard, Gilles

    2014-01-01

    Analogical reasoning is known as a powerful mode for drawing plausible conclusions and solving problems. It has been the topic of a huge number of works by philosophers, anthropologists, linguists, psychologists, and computer scientists. As such, it has been early studied in artificial intelligence, with a particular renewal of interest in the last decade. The present volume provides a structured view of current research trends on computational approaches to analogical reasoning. It starts with an overview of the field, with an extensive bibliography. The 14 collected contributions cover a large scope of issues. First, the use of analogical proportions and analogies is explained and discussed in various natural language processing problems, as well as in automated deduction. Then, different formal frameworks for handling analogies are presented, dealing with case-based reasoning, heuristic-driven theory projection, commonsense reasoning about incomplete rule bases, logical proportions induced by similarity an...

  20. Cyclic pentapeptide analogs based on endomorphin-2 structure: cyclization studies using liquid chromatography combined with on-line mass spectrometry and tandem mass spectrometry.

    Science.gov (United States)

    Piekielna, Justyna; Kluczyk, Alicja; Perlikowska, Renata; Janecka, Anna

    2014-05-01

    The cyclization of linear analogs based on endomorphin-2 structure, Tyr/Dmt-d-Lys-Phe-Phe-Asp-NH2 and Tyr/Dmt-d-Cys-Phe-Phe-Cys-NH2 (where Dmt=2',6'-dimethyltyrosine), resulting in obtaining lactam or disulfide derivatives, was studied using liquid chromatography combined with on-line mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS). In case of cyclization via an amide bond, the formation of the cyclic monomers, cyclic but not linear dimers and even traces of cyclic trimers was observed. Disulfide bridge containing peptides was obtained by the solid-phase synthesis of the linear sequences, followed by either in-solution or on-resin cyclization. In case of the in-solution cyclization, the expected cyclic monomers were the only products. When oxidation of the cysteine residues was performed when the peptides were still on the resin, cyclic monomer and two cyclodimers, parallel and antiparallel, were found. Digestion of the isolated cyclodimers with α-chymotrypsin allowed for their unambiguous identification. The comparison of the cyclic monomer/dimer ratios for analogs with Tyr versus Dmt in position 1 revealed that the presence of the exocyclic Dmt favored formation of the cyclic monomer, most likely due to the increased steric bulk of this amino acid side-chain as compared with Tyr. PMID:24525024

  1. In vitro and in vivo studies in Balb-c and nude mice of a new 177Lu-Bombesin analog developed for prostate tumor diagnosis and treatment

    International Nuclear Information System (INIS)

    In this work we describe the radiolabeling with 177Lu and some properties of the novel bombesin analog BBNp6 - DOTA-X-BBN(6-14), where X is a spacer of six aminoacids. Bombesin (BBN) is an analog of human gastrin releasing peptide (GRP) isolated from the skin of the frog Bombina bombina in 1970. Development of radiolabeled BBN derivatives as agents for diagnostic imaging and systemic radiotherapy has increased considerable because of the observation that GRP receptors (GRPr) are over-expressed in a variety of human tumor cells, such as prostate tumor cells. 177Lu-labeled peptides are attractive due to the excellent radiophysical properties and commercial availability of the radiometal. BBNp6 was labeled with high yield after reacting with 92.5 MBq of 177LuCl3 at 90 deg C for 30 minutes and this mixture kept stable for more than 96 hours at 4 deg C and 1 hour in human plasma. In vivo studies showed a multicompartimental distribution model with fast blood clearance, mainly performed by renal pathway. In addition, 177Lu-BBNp6 showed high affinity for PC-3 tumor xenografts, but not for pancreas and intestine (GRP positive tissues), suggesting its specificity and usefulness for prostate tumor treatment. Moreover, scintigraphic images showed that this derivative can also be a tool in this tumor diagnosis. So, BBNp6 is a promising radiopharmaceutical for prostate tumor imaging and treatment. (author)

  2. Digital and analog communication systems

    Science.gov (United States)

    Shanmugam, K. S.

    1979-01-01

    The book presents an introductory treatment of digital and analog communication systems with emphasis on digital systems. Attention is given to the following topics: systems and signal analysis, random signal theory, information and channel capacity, baseband data transmission, analog signal transmission, noise in analog communication systems, digital carrier modulation schemes, error control coding, and the digital transmission of analog signals.

  3. Analogical Reasoning in Geometry Education

    Science.gov (United States)

    Magdas, Ioana

    2015-01-01

    The analogical reasoning isn't used only in mathematics but also in everyday life. In this article we approach the analogical reasoning in Geometry Education. The novelty of this article is a classification of geometrical analogies by reasoning type and their exemplification. Our classification includes: analogies for understanding and setting a…

  4. Electrical analogous in viscoelasticity

    Science.gov (United States)

    Ala, Guido; Di Paola, Mario; Francomano, Elisa; Li, Yan; Pinnola, Francesco P.

    2014-07-01

    In this paper, electrical analogous models of fractional hereditary materials are introduced. Based on recent works by the authors, mechanical models of materials viscoelasticity behavior are firstly approached by using fractional mathematical operators. Viscoelastic models have elastic and viscous components which are obtained by combining springs and dashpots. Various arrangements of these elements can be used, and all of these viscoelastic models can be equivalently modeled as electrical circuits, where the spring and dashpot are analogous to the capacitance and resistance, respectively. The proposed models are validated by using modal analysis. Moreover, a comparison with numerical experiments based on finite difference time domain method shows that, for long time simulations, the correct time behavior can be obtained only with modal analysis. The use of electrical analogous in viscoelasticity can better reveal the real behavior of fractional hereditary materials.

  5. Automatic Licenses Plate Recognition

    OpenAIRE

    Ronak P Patel; Narendra M Patel; Keyur Brahmbhatt

    2013-01-01

    This paper describes the Smart Vehicle Screening System, which can be installed into a tollboothfor automated recognition of vehicle license plate information using a photograph of a vehicle. An automatedsystem could then be implemented to control the payment of fees, parking areas, highways, bridges ortunnels, etc. This paper contains new algorithm for recognition number plate using Morphological operation,Thresholding operation, Edge detection, Bounding box analysis for number plate extract...

  6. New capabilities for older aircraft: A study of pilot integration of retro-fit digital avionics to analog-instrumented flight decks

    Science.gov (United States)

    Breuer, Glynn E.

    The purpose of this study was to determine whether applying Gilbert's Behavior Engineering Model to military tactical aviation organizations would foster effective user integration of retro-fit digital avionics in analog-instrumented flight decks. This study examined the relationship between the reported presence of environmental supports and personal repertory supports as defined by Gilbert, and the reported self-efficacy of users of retro-fit digital avionics to analog flight decks, and examined the efficacious behaviors of users as they attain mastery of the equipment and procedures, and user reported best practices and criteria for masterful performance in the use of retro-fit digital avionics and components. This study used a mixed methodology, using quantitative surveys to measure the perceived level of organizational supports that foster mastery of retro-fit digital avionic components, and qualitative interviews to ascertain the efficacious behaviors and best practices of masterful users of these devices. The results of this study indicate that there is some relationship between the reported presence of organizational supports and personal repertory supports and the reported self-mastery and perceived organizational mastery of retro-fit digital avionics applied to the operation of the research aircraft. The primary recommendation is that unit leadership decide exactly the capabilities desired from retro-fit equipment, publish these standards, ensure training in these standards is effective, and evaluate performance based on these standards. Conclusions indicate that sufficient time and resources are available to the individual within the study population, and the organization as a whole, to apply Gilbert's criteria toward the mastery of retro-fit digital avionics applied to the operation of the research aircraft.

  7. Advanced reactor licensing issues

    International Nuclear Information System (INIS)

    In July 1986 the US Nuclear Regulatory Commission issued a Policy Statement on the Regulation of Advanced Nuclear Power Plants. As part of this policy advanced reactor designers were encouraged to interact with NRC early in the design process to obtain feedback regarding licensing requirements for advanced reactors. Accordingly, the staff has been interacting with the Department of Energy (DOE) and its contractors on the review of three advanced reactor conceptual designs: one modular High Temperature Gas-Cooled Reactor (MHTGR) and two Liquid Metal Reactors (LMRs). As a result of these interactions certain safety issues associated with these advanced reactor designs have been identified as key to the licensability of the designs as proposed by DOE. The major issues in this regard are: (1) selection and treatment of accident scenarios; (2) selection of siting source term; (3) performance and reliability of reactor shutdown and decay heat removal systems; (4) need for conventional containment; (5) need for conventional emergency evacuation; (6) role of the operator; (7) treatment of balance of plant; and (8) modular approach. This paper provides a status of the NRC review effort, describes the above issues in more detail and provides the current status and approach to the development of licensing guidance on each

  8. Study of the photon-induced formation and subsequent desorption of CH3OH and H2CO in interstellar ice analogs

    Science.gov (United States)

    Martín-Doménech, R.; Muñoz Caro, G. M.; Cruz-Díaz, G. A.

    2016-04-01

    Context. Methanol and formaldehyde are two simple organic molecules that are ubiquitously detected in the interstellar medium, in both the solid and gaseous phases. An origin in the solid phase and a subsequent nonthermal desorption into the gas phase is often invoked to explain their abundances in some of the environments where they are found. Experimental simulations under astrophysically relevant conditions have been carried out in the past four decades in order to find a suitable mechanism for that process. Aims: In particular, photodesorption from pure methanol ice (and presumably from pure formaldehyde ice) has been found to be negligible in previous works, probably because both molecules are very readily dissociated by vacuum-UV photons. Therefore, we explore the in situ formation and subsequent photon-induced desorption of these species, studying the UV photoprocessing of pure ethanol ice, and a more realistic binary H2O:CH4 ice analog. Methods: Experimental simulations were performed in an ultra-high vacuum chamber. Pure ethanol and binary H2O:CH4 ice samples deposited onto an infrared transparent window at 8 K were UV-irradiated using a microwave-discharged hydrogen flow lamp. Evidence of photochemical production of these two species and subsequent UV-photon-induced desorption into the gas phase were searched for by means of a Fourier transform infrared spectrometer and a quadrupole mass spectrometer, respectively. After irradiation, ice samples were warmed up to room temperature until complete sublimation was attained for detection of volatile products. Results: Formation of CH3OH was only observed during photoprocessing of the H2O:CH4 ice analog, accounting for ~4% of the initial CH4 ice column density, but no photon-induced desorption was detected. Photochemical production of H2CO was observed in both series of experiments. Formation of formaldehyde accounted for ≤45% conversion of the initial ethanol ice, but it could not be quantified during

  9. Ground Penetrating Radar Field Studies of Lunar-Analog Geologic Settings and Processes: Barringer Meteor Crater and Northern Arizona Volcanics

    Science.gov (United States)

    Russell, P. S.; Grant, J. A.; Williams, K. K.; Bussey, B.

    2010-12-01

    Ground-Penetrating Radar (GPR) data from terrestrial analog environments can help constrain models for evolution of the lunar surface, aid in interpretation of orbital SAR data, and help predict what might be encountered in the subsurface during future, landed, scientific or engineering operations on the Moon. GPR can yield insight into the physical properties, clast-size distribution, and layering of the subsurface, granting a unique view of the processes affecting an area over geologic time. The purpose of our work is to demonstrate these capabilities at sites at which geologic processes, settings, and/or materials are similar to those that may be encountered on the moon, especially lava flows, impact-crater ejecta, and layered materials with varying properties. We present results from transects obtained at Barringer Meteor Crater, SP Volcano cinder cone, and Sunset Crater Volcano National Monument, all in northern Arizona. Transects were taken at several sites on the ejecta of Meteor Crater, all within a crater radius (~400 m) of the crater rim. Those taken across ejecta lobes or mounds reveal the subsurface contact of the ejecta upper surface and overlying, embaying sediments deposited by later alluvial, colluvial, and/or aeolian processes. Existing mine shafts and pits on the south side of the crater provide cross sections of the subsurface against which we compare adjacent GPR transects. The ‘actual’ number, size, and depth of clasts in the top 1-2 m of the subsurface are estimated from photos of the exposed cross sections. In GPR radargrams, reflections attributed to blocks in the top 2-5 m of the subsurface are counted, and their depth distribution noted. Taking GPR measurements along a transect at two frequencies (200 and 400 MHz) and to various depths, we obtain the ratio of the actual number of blocks in the subsurface to the number detectable with GPR, as well as an assessment of how GPR detections in ejecta decline with depth and depend on antenna

  10. Quantum Analog Computing

    Science.gov (United States)

    Zak, M.

    1998-01-01

    Quantum analog computing is based upon similarity between mathematical formalism of quantum mechanics and phenomena to be computed. It exploits a dynamical convergence of several competing phenomena to an attractor which can represent an externum of a function, an image, a solution to a system of ODE, or a stochastic process.

  11. Towards analogy in toponyms

    Czech Academy of Sciences Publication Activity Database

    Štěpán, Pavel

    Cluj : Mega, 2013 - (Felecan, O.), s. 379-383 ISBN 978-606-543-343-4. [Name and Naming /2./ Onomastics in Contemporary Public Space. Baia Mare (RO), 09.05.2013-11.05.2013] R&D Projects: GA ČR GPP406/12/P600 Institutional support: RVO:68378092 Keywords : onomastics * toponyms * analogy Subject RIV: AI - Linguistics

  12. Commitment of Licensed Social Workers to Aging Practice

    Science.gov (United States)

    Simons, Kelsey; Bonifas, Robin; Gammonley, Denise

    2011-01-01

    This study sought to identify client, professional, and employment characteristics that enhance licensed social workers' commitment to aging practice. A series of binary logistic regressions were performed using data from 181 licensed, full-time social workers who reported aging as their primary specialty area as part of the 2004 NASW's national…

  13. Study on radiolabeling of 1, 2, 3-triazole analogs with fac-[188Re(CO)3(H2O)3]+ via click chemistry

    International Nuclear Information System (INIS)

    Click chemistry was used to study on radiolabeling of 1, 2, 3-triazole analogs with. fac-[188Re(CO)3(H2O)3]+. CuSO4/L-sodium ascorbate was chosen as the catalyst system, three terminal alkynes were conjugated with two different azides respectively, and then the new prepared fac-[188Re(CO)3(H2O)3]+ was coordinated to the six triazoles. The results showed that the radiochemical yields (RCY) of the conjugation of fac-[188Re(CO)3]+ with six triazoles were over 90%, and the triazoles showed high stability in phosphate-buffered saline and new-born calf serum. The preliminary biological evaluation results showed that the new 188Re-labeling method via click chemistry could have general application in labeling bioactive molecules in high radiochemical yield and high specific activity for further SPECT research. (authors)

  14. FTIR-ATR study of the influence of the pyrimidine analog of fluphenazine on the chain-melting phase transition of sphingomyelin membranes

    Science.gov (United States)

    Kuć, Marta; Cieślik-Boczula, Katarzyna; Świątek, Piotr; Jaszczyszyn, Agata; Gąsiorowski, Kazimierz; Malinka, Wiesław

    2015-09-01

    The membrane perturbing potency of the highly effective anti-multidrug resistance (MDR) pyrimidine analog of fluphenazine (FPh-prm), has been studied using attenuated total reflectance Fourier-transfer infrared spectroscopy (FTIR-ATR). The temperature- and FPh-prm-dose-dependent evolutions of the infrared spectra of FPh-prm/sphingomyelin (SM) mixtures were analyzed using principal component analysis (PCA). It has been postulated that the distinct anti-MDR activity of FPh-prm could be related to its ability to affect the modification of SM membranes. A reduction in the temperature of the chain-melting phase transition was observed in FPh-prm-mixed SM membranes together with the loosing of the phase transition cooperativity. Increasing the temperature led to the trans to gauche isomerization of FPh-prm-rich lipid membranes, which resulted in the gradual release of FPh-prm from the lipid membrane to the water phase.

  15. Comparative evaluation of pressure generated on a simulated maxillary oral analog by impression materials in custom trays of different spacer designs: An in vitro study

    Science.gov (United States)

    Chopra, Sakshi; Gupta, Narendra Kumar; Tandan, Amrit; Dwivedi, Ravi; Gupta, Swati; Agarwal, Garima

    2016-01-01

    Introduction: Literature reveals that masticatory load on denture bearing tissues through complete dentures should be maximum on primary stress bearing areas and least on relief area in accordance with the histology of underlying tissues. A study to validate the existing beliefs was planned to compare the pressure on mucosa using selective pressure technique and minimal pressure technique, with the incorporation of two different impression materials utilizing the pressure sensors during secondary impression procedure. Materials and Methods: The study was performed using a maxillary analog. Three pressure sensors were imbedded in the oral analog, one in the mid palatine area and the other two in the right and left ridge crest. Custom trays of two different configurations were fabricated. The two impression materials tested were light body and zinc oxide eugenol. A total of 40 impressions were made. A constant weight of 1 kg was placed, and the pressure was recorded as initial and end pressures. Results: A significant difference in the pressure produced using different impression materials was found (P zinc oxide eugenol impression materials. The presence of relief did affect the magnitude of pressure at various locations. Conclusion: All impression materials produced pressure during maxillary edentulous impression making. Tray modification is an important factor in changing the amount of pressure produced. The impression materials used also had a significant role to play on the pressures acting on the tissues during impression procedure. Clinical Implication: Light body VPS impression material may be recommended to achieve minimal pressure on the denture bearing tissues in both selective as well as minimal pressure techniques. PMID:27041902

  16. Comparative evaluation of pressure generated on a simulated maxillary oral analog by impression materials in custom trays of different spacer designs: An in vitro study

    Directory of Open Access Journals (Sweden)

    Sakshi Chopra

    2016-01-01

    Full Text Available Introduction: Literature reveals that masticatory load on denture bearing tissues through complete dentures should be maximum on primary stress bearing areas and least on relief area in accordance with the histology of underlying tissues. A study to validate the existing beliefs was planned to compare the pressure on mucosa using selective pressure technique and minimal pressure technique, with the incorporation of two different impression materials utilizing the pressure sensors during secondary impression procedure. Materials and Methods: The study was performed using a maxillary analog. Three pressure sensors were imbedded in the oral analog, one in the mid palatine area and the other two in the right and left ridge crest. Custom trays of two different configurations were fabricated. The two impression materials tested were light body and zinc oxide eugenol. A total of 40 impressions were made. A constant weight of 1 kg was placed, and the pressure was recorded as initial and end pressures. Results: A significant difference in the pressure produced using different impression materials was found (P < 0.001. Light body vinyl polysiloxane produced significantly lesser pressure than zinc oxide eugenol impression materials. The presence of relief did affect the magnitude of pressure at various locations. Conclusion: All impression materials produced pressure during maxillary edentulous impression making. Tray modification is an important factor in changing the amount of pressure produced. The impression materials used also had a significant role to play on the pressures acting on the tissues during impression procedure. Clinical Implication: Light body VPS impression material may be recommended to achieve minimal pressure on the denture bearing tissues in both selective as well as minimal pressure techniques.

  17. Fostering Multilateral Involvement in Analog Research

    Science.gov (United States)

    Cromwell, Ronita L.

    2015-01-01

    International collaboration in space flight research is an effective means for conducting investigations and utilizing limited resources to the fullest extent. Through these multilateral collaborations mutual research questions can be investigated and resources contributed by each international partner to maximize the scientific benefits to all parties. Recently the international partners embraced this approach to initiate collaborations in ground-based space flight analog environments. In 2011, the International Analog Research Working Group was established, and later named the International Human Space Flight Analog Research Coordination Group (HANA). Among the goals of this working group are to 1) establish a framework to coordinate research campaigns, as appropriate, to minimize duplication of effort and enhance synergy; 2) define what analogs are best to use for collaborative interests; and 3) facilitate interaction between discipline experts in order to have the full benefit of international expertise. To accomplish these goals, HANA is currently engaged in developing international research campaigns in ground-based analogs. Plans are being made for an international solicitation for proposals to address research of common interest to all international partners. This solicitation with identify an analog environment that will best accommodate the types of investigations requested. Once selected, studies will be integrated into a campaign and implemented at the analog site. Through these combined efforts, research beneficial to all partners will be conducted efficiently to further address human risks of space exploration.

  18. Regulatory requirements for replacement of analog systems with digital upgrades

    International Nuclear Information System (INIS)

    This paper reviews briefly the regulatory guidelines which must be met in order to replace analog systems in nuclear power plants with digital systems. There is a move to do such replacements for a number of reasons: analog systems are aging, and showing considerable drift; few vendors manufacture analog systems today; support and parts are hard to get; digital systems provide flexibility. There is a safety concern however about undesirable and unpredictable effects to digital safety equipment due to plant transients, accidents, post-accident condition, and EMI/RF environmental interferences. License holders must comply with the requirements of 10 C.F.R. 50.59, which deals with safety concerns with respect to any changes to operating plants which may have an impact on the safety of the plant. NRC staff is taking the position that all digital upgrades will require an evaluation under this regulation

  19. Exporting the Canadian licensing program

    International Nuclear Information System (INIS)

    This paper deals with the problems of an overseas regulatory agency in licensing a Canadian-supplied nuclear plant which is referenced to a plant in Canada. Firstly, the general problems associated with the use of a reference plant are discussed. This is followed by a discussion of specific problems which arise from the licensing practices in Canada. The paper concludes with recommendations to simplify the task of demonstrating the licensability of an overseas CANDU plant

  20. Patent license negotiation :best practices

    OpenAIRE

    Giordano-Coltart, J. (Jennifer); Calkins, C.W. (Charles)

    2009-01-01

    In all areas of the biotechnology and pharmaceutical industries, the licensing of intellectual property is in most cases an essential step in the translation of basic research into a commercial product. Negotiating IP licensing agreements and developing the terms of the business transaction involve evaluating numerous factors pertaining to the specific circumstances of the parties and the technology at issue. As the quality of the business relationship after licensing of the intellectual prop...

  1. Licensed operating reactors

    International Nuclear Information System (INIS)

    The Operating Units Status Report --- Licensed Operating Reactors provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management from the Headquarters staff on NRC's Office of Enforcement (OE), from NRC's Regional Offices, and from utilities. The three sections of the report are: monthly highlights and statistics for commercial operating units, and errata from previously reported data; a compilation of detailed information on each unit, provided by NRC's Regional Offices, OE Headquarters and the utilities; and an appendix for miscellaneous information such as spent fuel storage capability, reactor-years of experience and non- power reactors in the US

  2. Licensed operating reactors

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission's monthly Licensed Operating Reactors Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. Since all of the data concerning operation of the units is provided by the utility operators less than two weeks after the end of the month, necessary corrections to published information are shown on the errata page

  3. Validation, acceptance and licensing

    International Nuclear Information System (INIS)

    The licensing process requires communication of complex scientific and technical information. In this paper transfer of such information is discussed using concepts and ideas from systems analysis, cybernetics and argumentation theory. A simple model for the decision process is developed. The analysis stresses the need for careful design of the communication channels between the three systems involved: the political system, the judicial-regulatory system and the scientific-technical community. The Dialogue - Scenario project initiated by the Swedish nuclear Inspectorate is briefly presented

  4. FCC Universal Licensing System (ULS)

    Data.gov (United States)

    Federal Communications Commission — The Universal Licensing System allows electronic filing of applications processed by the Commission. The ULS allows you to indicate the application purpose and...

  5. Operating reactors licensing actions summary

    International Nuclear Information System (INIS)

    The operating reactors licensing actions summary is designed to provide the management of the Nuclear Regulatory Commission (NRC) with an overview of licensing actions dealing with operating power and nonpower reactors. These reports utilize data collected from the Division of Licensing in the Office of Nuclear Reactor Regulation and are prepared by the Office of Management and Program Analysis. This summary report is published primarily for internal NRC use in managing the operating reactors licensing actions program. Its content will change based on NRC management informational requirements

  6. Implementing neural architectures using analog VLSI circuits

    OpenAIRE

    Maher, Mary Ann C.; DeWeerth, Stephen P.; Mahowald, Misha A.; Mead, Carver A.

    1989-01-01

    Analog very large-scale integrated (VLSI) technology can be used not only to study and simulate biological systems, but also to emulate them in designing artificial sensory systems. A methodology for building these systems in CMOS VLSI technology has been developed using analog micropower circuit elements that can be hierarchically combined. Using this methodology, experimental VLSI chips of visual and motor subsystems have been designed and fabricated. These chips exhibit behavior similar to...

  7. USW area analogs

    OpenAIRE

    Everett, Keith R.

    2005-01-01

    The purpose of this project is to investigate the feasibility of and methodology for the development of a set of environmental analogs of operational Undersea Warfare (USW) areas within fleet training areas. It is primarily a discussion of the identification of parameters that characterize the tactical USW environment, prioritization of these parameters, identification of existing databases that contain these parameters and an outline of the processes required to extract the desired data fro...

  8. Analogy, Explanation, and Proof

    Directory of Open Access Journals (Sweden)

    John eHummel

    2014-11-01

    Full Text Available People are habitual explanation generators. At its most mundane, our propensity to explain allows us to infer that we should not drink milk that smells sour; at the other extreme, it allows us to establish facts (e.g., theorems in mathematical logic whose truth was not even known prior to the existence of the explanation (proof. What do the cognitive operations underlying the (inductive inference that the milk is sour have in common with the (deductive proof that, say, the square root of two is irrational? Our ability to generate explanations bears striking similarities to our ability to make analogies. Both reflect a capacity to generate inferences and generalizations that go beyond the featural similarities between a novel problem and familiar problems in terms of which the novel problem may be understood. However, a notable difference between analogy-making and explanation-generation is that the former is a process in which a single source situation is used to reason about a single target, whereas the latter often requires the reasoner to integrate multiple sources of knowledge. This small-seeming difference poses a challenge to the task of marshaling our understanding of analogical reasoning in the service of understanding explanation. We describe a model of explanation, derived from a model of analogy, adapted to permit systematic violations of this one-to-one mapping constraint. Simulation results demonstrate that the resulting model can generate explanations for novel explananda and that, like the explanations generated by human reasoners, these explanations vary in their coherence.

  9. ADSL Analog Front End

    OpenAIRE

    Stojković, Nino

    2006-01-01

    In this paper the Asymmetric Digital Subscriber Line (ADSL) analog front end (AFE) designs are described and compared. AFE is the part of ADSL modems most responsible for quality signal transmission over phone wires. It can be divided into the transmitting path (TX) circuitry, the receiving path (RX) circuitry and the hybrid network and transformer. The operations and realizations of each functional block are presented. There are the D/A converter, the filter and the line driver in the TX pat...

  10. Analog Signal Processing

    OpenAIRE

    Caloz, Christophe; Gupta, Shulabh; Zhang, Qingfeng; Nikfal, Babak

    2013-01-01

    Analog signal processing (ASP) is presented as a systematic approach to address future challenges in high speed and high frequency microwave applications. The general concept of ASP is explained with the help of examples emphasizing basic ASP effects, such as time spreading and compression, chirping and frequency discrimination. Phasers, which represent the core of ASP systems, are explained to be elements exhibiting a frequency-dependent group delay response, and hence a nonlinear phase resp...

  11. Post licensing case study of community effects at two operating nuclear power plants. Final report, March 1975--March 1976

    Energy Technology Data Exchange (ETDEWEB)

    Purdy, B.J.; Peelle, E.; Bjornstad, D.J.; Mattingly, T.J. Jr.; Soderstrom, J.; DeVault, R.C.

    1976-06-01

    The social, economic, and political/institutional impacts of two operating nuclear power complexes on two New England communities are studied. The report includes discussions of the study design and objectives, profiles of the towns of Plymouth, Massachusetts, and Waterford, Connecticut, and analysis of the social, economic, and political impacts as observed by members of the ORNL staff. Results are presented from an attitude survey as well as a social impact classification schema devised as a methodological tool.

  12. Post licensing case study of community effects at two operating nuclear power plants. Final report, March 1975--March 1976

    International Nuclear Information System (INIS)

    The social, economic, and political/institutional impacts of two operating nuclear power complexes on two New England communities are studied. The report includes discussions of the study design and objectives, profiles of the towns of Plymouth, Massachusetts, and Waterford, Connecticut, and analysis of the social, economic, and political impacts as observed by members of the ORNL staff. Results are presented from an attitude survey as well as a social impact classification schema devised as a methodological tool

  13. A Transiting Jupiter Analog

    CERN Document Server

    Kipping, David M; Henze, Chris; Teachey, Alex; Isaacson, Howard T; Petigura, Erik A; Marcy, Geoffrey W; Buchhave, Lars A; Chen, Jingjing; Bryson, Steve T; Sandford, Emily

    2016-01-01

    Decadal-long radial velocity surveys have recently started to discover analogs to the most influential planet of our solar system, Jupiter. Detecting and characterizing these worlds is expected to shape our understanding of our uniqueness in the cosmos. Despite the great successes of recent transit surveys, Jupiter analogs represent a terra incognita, owing to the strong intrinsic bias of this method against long orbital periods. We here report on the first validated transiting Jupiter analog, Kepler-167e (KOI-490.02), discovered using Kepler archival photometry orbiting the K4-dwarf KIC-3239945. With a radius of $(0.91\\pm0.02)$ $R_{\\mathrm{Jup}}$, a low orbital eccentricity ($0.06_{-0.04}^{+0.10}$) and an equilibrium temperature of $(131\\pm3)$ K, Kepler-167e bears many of the basic hallmarks of Jupiter. Kepler-167e is accompanied by three Super-Earths on compact orbits, which we also validate, leaving a large cavity of transiting worlds around the habitable-zone. With two transits and continuous photometric ...

  14. Spiral structure in galaxies: analogies

    Energy Technology Data Exchange (ETDEWEB)

    Kirkpatrick, R.C.

    1976-01-01

    The vortex analogy to galactic spiral structures is considered. Caution against carrying the analogy past its region of applicability is noted; and some experiments with vorticities are mentioned. (JFP)

  15. Blast from the past? A comparative analysis of broadcasting licensing in the digital era

    OpenAIRE

    Schweizer, Corinne; Puppis, Manuel; Künzler, Matthias (Hrsg.); Studer, Samuel

    2014-01-01

    The advent of new broadcasting technologies has eliminated spectrum scarcity as a constraint on broadcasting, and with it one of the justifications for broadcast licensing. Have nations moved away from licensing as a form of regulation of their broadcasting sectors? And concomitantly, is there less opportunity to use licensing as a means of promoting the public interest in broadcasting? The authors address these questions through a comparative study of licensing requirements for terrestrial b...

  16. Licensing Trends for Construction of New Nuclear Plants

    International Nuclear Information System (INIS)

    Currently in Korea, an SFR (Sodium-cooled Fast Reactor) technology proving stage reactor called PGSFR (Prototype Gen-IV SFR) is being developed by KAERI and KEPCO E and C to be constructed by 2028. After the accident of the Fukushima nuclear power plants, how to regulate and license newly developing nuclear reactors requiring higher safety goals has been issued. As a result, in leading nuclear nations developing new reactors, the close cooperation between the developer and the regulator is becoming very important. In this study, the licensing processes of leading nuclear countries were surveyed and compared with that of Korea, and a new licensing direction for PGSFR was suggested. Reviewing licensing processes for newly developing reactors of other countries, the first step of the licensing process is the pre-safety review, which is to review the reactor design. This process is not legally binding, but is a review process for a better understanding of newly applied technologies by regulators prior to starting the legally binding licensing process as the construction and operation licensing. This process provides an opportunity for the reactor developer to adopt the regulator's licensing direction and a goal to designing newly developing reactors to meet the safety requirements

  17. The Age of Analog Networks

    OpenAIRE

    Mattiussi, Claudio; Swiss Federal Institute of Technology in Lausanne (EPFL); Marbach, Daniel; Swiss Federal Institute of Technology in Lausanne (EPFL); Dürr, Peter; Swiss Federal Institute of Technology in Lausanne (EPFL); Floreano, Dario; Swiss Federal Institute of Technology in Lausanne (EPFL)

    2008-01-01

    A large class of systems of biological and technological relevance can be described as analog networks, that is, collections of dynamical devices interconnected by links of varying strength. Some examples of analog networks are genetic regulatory networks, metabolic networks, neural networks, analog electronic circuits, and control systems. Analog networks are typically complex systems which include nonlinear feedback loops and possess temporal dynamics at different timescales. When tackled b...

  18. Children with Disabilities in the Child Protective Services System: An Analog Study of Investigation and Case Management

    Science.gov (United States)

    Manders, Jeanette E.; Stoneman, Zolinda

    2009-01-01

    Objective: The study used a series of vignettes to investigate how the presence of three disabilities (cerebral palsy, intellectual disabilities, emotional/behavioral disabilities) affects the processes and outcomes of child abuse investigations at two levels of child injury severity (moderate, severe). Method: Seventy-five CPS case workers…

  19. Use of insulin and insulin analogs and risk of cancer - systematic review and meta-analysis of observational studies

    DEFF Research Database (Denmark)

    Karlstad, Oystein; Starup-Linde, Jacob; Vestergaard, Peter;

    2013-01-01

    . Meta-analyses were significant for: Insulin vs No Insulin: Increased risk for pancreas, liver, kidney, stomach and respiratory cancer, decreased risk for prostate cancer. Insulin vs Non-Insulin Antidiabetics: Increased risk for any, pancreatic and colorectal cancer. Glargine vs Non-Glargine Insulin......BACKGROUND: An association of insulin use and risk of cancer has been reported but evidence is conflicting and methodological issues have been identified. OBJECTIVE: To summarize results regarding insulin use and cancer risk by a systematic review and meta-analysis of cohort and case......-control studies examining risk of cancer associated with insulin use in patients with diabetes. DATA SOURCES: Systematic literature search in 5 databases: PubMed, Embase, Web of Science, Scopus and Cochrane Library. STUDY ELIGIBILITY CRITERIA (PICOS): POPULATION: diabetes patients. EXPOSURE: Users of any...

  20. WNA Licensing and Permitting Survey

    International Nuclear Information System (INIS)

    This presentation treats of licensing and permitting practices - views of the international nuclear industry. It provides an overview of a survey by WNA on licensing that was completed in September 2012. It explains that responses to the survey were received from utilities, vendors and architect engineer firms across 4 continents. It notes that all nuclear stakeholders agree that safety and security is paramount in any licensing process. It also notes that the survey focuses the interaction of regulatory process with the industry's commercial activities, such as procurement, contracting, and finance. The results of the survey indicate that one licensing model does not fit all and that the regulatory, political and economic environments are very diverse across countries. The presentation highlights differences and some pros and cons for one-step and two-or multi-step licensing. It also highlights the importance of pre-licensing activities. It notes that vendor and site selection are also different and can be commercial or government influenced. Regarding contracting, the survey indicates that it is not practical to develop or advocate for standardization because of the diversity of factors driving commercial considerations. Regarding financing, it highlights the importance of a clear and predictable licensing regime to the availability of financing. It concludes by noting that international harmonization of safety requirements and standardization of designs would greatly facilitate licensing, although there still remains a long way to go in that regard

  1. Responsibilities of NARM Licensing States

    International Nuclear Information System (INIS)

    There are 30 Licensing States of Naturally Occurring and Accelerator-Produced Radioactive Materials (NARM) in the U.S. In these States NARM is licensed in a similar manner as is by-product material in the Agreement States. Each Licensing State has the responsibility to identify and evaluate NARM products including informing other State and Federal radiation control agencies of potential problems encountered during the lifetime of the product. Licensing States have authority to perform on-site inspections of manufacturers, enforce radiation regulations, require compliance with all conditions of the license, and amend or terminate the license for possession and use of NARM. A Licensing State also has the responsibility to accept the recommendation on NARM products evaluated by other Licensing States. To assist States in the evaluation of NARM products the Conference of Radiation Control Program Directors developed a report entitled 'Guides for Naturally Occurring and Accelerator-Produced Radioactive Materials (NARM).' The NARM Guides report (HEW Publication (FDA) 77-8025) was published by the Bureau of Radiological Health/FDA in July 1977. The NARM Guides establish uniform criteria for evaluating the manufacture, assembly and distribution of NARM products in the U.S. The Radioactive Materials Reference Manual which is coordinated by BRH/FDA is the medium for communicating NARM information with the radiation control agencies of the 50 States, certain Federal and local agencies. (author)

  2. Sulfates on Mars as Markers of Aqueous Processes: An Integrated Multidisciplinary Study of Minerals, Mars Analog sites and Recent Mission Data

    Science.gov (United States)

    Bishop, J. L.; Lane, M. D.; Dyar, M. D.; Brown, A. J.; Parente, M.

    2006-01-01

    Our analyses of sulfate minerals, analog sites, and Martian spectra and spectral images is focused on characterization of the Martian surface and in particular identification of aqueous processes there.

  3. Potential of Probing the Lunar Regolith using Rover-Mounted Ground Penetrating Radar: Moses Lake Dune Field Analog Study

    Science.gov (United States)

    Horz, F.; Heggy, E.; Fong, T.; Kring, D.; Deans, M.; Anglade, A.; Mahiouz, K.; Bualat, M.; Lee, P.; Bluethmann, W.

    2009-01-01

    Probing radars have been widely recognized by the science community to be an efficient tool to explore lunar subsurface providing a unique capability to address several scientific and operational issues. A wideband (200 to 1200 MHz) Ground Penetrating Radar (GPR) mounted on a surface rover can provide high vertical resolution and probing depth from few tens of centimeters to few tens of meters depending on the sounding frequency and the ground conductivity. This in term can provide a better understand regolith thickness, elemental iron concentration (including ilmenite), volatile presence, structural anomalies and fracturing. All those objectives are of important significance for understanding the local geology and potential sustainable resources for future landing sites in particular exploring the thickness, structural heterogeneity and potential volatiles presence in the lunar regolith. While the operation and data collection of GPR is a straightforward case for most terrestrial surveys, it is a challenging task for remote planetary study especially on robotic platforms due to the complexity of remote operation in rough terrains and the data collection constrains imposed by the mechanical motion of the rover and limitation in data transfer. Nevertheless, Rover mounted GPR can be of great support to perform systematic subsurface surveys for a given landing site as it can provide scientific and operational support in exploring subsurface resources and sample collections which can increase the efficiency of the EVA activities for potential human crews as part of the NASA Constellation Program. In this study we attempt to explore the operational challenges and their impact on the EVA scientific return for operating a rover mounted GPR in support of potential human activity on the moon. In this first field study, we mainly focused on the ability of GPR to support subsurface sample collection and explore shallow subsurface volatiles.

  4. Structure Based Docking and Molecular Dynamic Studies of Plasmodial Cysteine Proteases against a South African Natural Compound and its Analogs.

    Science.gov (United States)

    Musyoka, Thommas M; Kanzi, Aquillah M; Lobb, Kevin A; Tastan Bishop, Özlem

    2016-01-01

    Identification of potential drug targets as well as development of novel antimalarial chemotherapies with unique mode of actions due to drug resistance by Plasmodium parasites are inevitable. Falcipains (falcipain-2 and falcipain-3) of Plasmodium falciparum, which catalyse the haemoglobin degradation process, are validated drug targets. Previous attempts to develop peptide based drugs against these enzymes have been futile due to the poor pharmacological profiles and susceptibility to degradation by host enzymes. This study aimed to identify potential non-peptide inhibitors against falcipains and their homologs from other Plasmodium species. Structure based virtual docking approach was used to screen a small non-peptidic library of natural compounds from South Africa against 11 proteins. A potential hit, 5α-Pregna-1,20-dien-3-one (5PGA), with inhibitory activity against plasmodial proteases and selectivity on human cathepsins was identified. A 3D similarity search on the ZINC database using 5PGA identified five potential hits based on their docking energies. The key interacting residues of proteins with compounds were identified via molecular dynamics and free binding energy calculations. Overall, this study provides a basis for further chemical design for more effective derivatives of these compounds. Interestingly, as these compounds have cholesterol-like nuclei, they and their derivatives might be well tolerated in humans. PMID:27030511

  5. Study of nuclear reactions and analog isobar states in the system He8 + p for low energy with the help of MAYA active target

    International Nuclear Information System (INIS)

    With the resent improvements in the field of exotics beams, and specially with the SPIRAL facility at GANIL, we were able to study He9 shell inversion already known for Be11 and Li10, which are two members of the N=7 family. A new detector was developed and also the software tools for the data analysis. This detector is at the same time the target (active-target) and is called MAYA. The He9 was studied by determining the properties of its isobaric analogue states in Li9. The characteristics of the IAS (isomeric analog state) states were determined by an analysis of the resonances in the elastic scattering cross section for He8 + p from 2 up to 3.9 MeV/n. A study of (p,d) and (p,t) reactions was done too, in this domain of energy. By comparing the experimental results with calculations, an assignation of spin and parity for two states in He9 was possible. (author)

  6. MEMS-based flexible reflective analog modulators (FRAM) for projection displays: a technology review and scale-down study

    Science.gov (United States)

    Picard, Francis; Ilias, Samir; Asselin, Daniel; Boucher, Marc-André; Duchesne, François; Jacob, Michel; Larouche, Carl; Vachon, Carl; Niall, Keith K.; Jerominek, Hubert

    2011-02-01

    A MEMS based technology for projection display is reviewed. This technology relies on mechanically flexible and reflective microbridges made of aluminum alloy. A linear array of such micromirrors is combined with illumination and Schlieren optics to produce a pixels line. Each microbridge in the array is individually controlled using electrostatic actuation to adjust the pixels intensities. Results of the simulation, fabrication and characterization of these microdevices are presented. Activation voltages below 250 V with response times below 10 μs were obtained for 25 μm × 25 μm micromirrors. With appropriate actuation voltage waveforms, response times of 5 μs and less are achievable. A damage threshold of the mirrors above 8 kW/cm2 has been evaluated. Development of the technology has produced projector engines demonstrating this light modulation principle. The most recent of these engines is DVI compatible and displays VGA video streams at 60 Hz. Recently applications have emerged that impose more stringent requirements on the dimensions of the MEMS array and associated optical system. This triggered a scale down study to evaluate the minimum micromirror size achievable, the impact of this reduced size on the damage threshold and the achievable minimum size of the associated optical system. Preliminary results of this scale down study are reported. FRAM with active surface as small as 5 μm × 5 μm have been investigated. Simulations have shown that such micromirrors could be activated with 107 V to achieve f-number of 1.25. The damage threshold has been estimated for various FRAM sizes. Finally, design of a conceptual miniaturized projector based on 1000×1 array of 5 μm × 5 μm micromirrors is presented. The volume of this projector concept is about 12 cm3.

  7. MEMS-based flexible reflective analog modulators (FRAM) for projection displays: a technology review and scale-down study

    International Nuclear Information System (INIS)

    A MEMS based technology for projection display is reviewed. This technology relies on mechanically flexible and reflective microbridges made of aluminum alloy. A linear array of such micromirrors is combined with illumination and Schlieren optics to produce a pixels line. Each microbridge in the array is individually controlled using electrostatic actuation to adjust the pixels intensities. Results of the simulation, fabrication and characterization of these microdevices are presented. Activation voltages below 250 V with response times below 10 μs were obtained for 25 μm x 25 μm micromirrors. With appropriate actuation voltage waveforms, response times of 5 μs and less are achievable. A damage threshold of the mirrors above 8 kW/cm2 has been evaluated. Development of the technology has produced projector engines demonstrating this light modulation principle. The most recent of these engines is DVI compatible and displays VGA video streams at 60 Hz. Recently applications have emerged that impose more stringent requirements on the dimensions of the MEMS array and associated optical system. This triggered a scale down study to evaluate the minimum micromirror size achievable, the impact of this reduced size on the damage threshold and the achievable minimum size of the associated optical system. Preliminary results of this scale down study are reported. FRAM with active surface as small as 5 μm x 5 μm have been investigated. Simulations have shown that such micromirrors could be activated with 107 V to achieve f-number of 1.25. The damage threshold has been estimated for various FRAM sizes. Finally, design of a conceptual miniaturized projector based on 1000x1 array of 5 μm x 5 μm micromirrors is presented. The volume of this projector concept is about 12 cm3.

  8. Licensing Experience for EPR Flamanville 3

    International Nuclear Information System (INIS)

    This presentation discusses the three stages of the EPR Flamanville 3 Licensing process: the political decision to build a new nuclear power plant, the authorization decree for nuclear power plant creation/construction license, and the commission and operation license. The operating license process requires the operator to submit the safety analysis report, the general operating rules, a study on waste management, the onsite emergency plan, and an update, as necessary of the decommissioning plan and the environmental impact assessment. The presentation follows with a discussion on the licensing of the Flamanville 3 EPR reactor. Flamanville 3 licensing was a longstanding and continuous process taking 18 years for the 3 main steps (1989 to 2007) and resulting in the authorization decree. The presentation describes the safety objectives utilized in the process, the integration of recent operating experience, innovations, and design and manufacturing. It also highlights several examples of modifications that resulted from the technical assessment supporting the authorization decree, including diversification of emergency electrical supply, practical elimination of fuel melt in the fuel pool, and diversification of heat sink and essential service water system. It reviews the contents of the authorization decree. Next, it discusses current on-going activities and milestones related to commissioning and operating license application and notes that current ASN/IRSN review activities are focused on a number of topics, including accident studies, I and C, protection system, internal and external events, detailed design of systems playing a safety role as supporting systems, equipment qualification to accident conditions, radiological consequences, several accident management, probabilistic studies, and several other topics. It explains that a 'focusing' review principle is used to inform the level of review for each topic. This principle is used to choose the SSCs that will

  9. Licensed operating reactors

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission's monthly Licensed Operating Reactors Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the Utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  10. Licensed operating reactors

    International Nuclear Information System (INIS)

    THE OPERATING UNITS STATUS REPORT - LICENSED OPERATING REACTORS provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management from the Headquarters staff of NRC's Office of Enforcement (OE), from NRC's Regional Offices, and from utilities. The three sections of the report are: monthly highlights and statistics for commercial operating units, and errata from previously reported data; a compilation of detailed information on each unit, provided by NRC's Regional Offices, OE Headquarters and the utilities; and an appendix for miscellaneous information such as spent fuel storage capability, reactor-years of experience and non-power reactors in the US

  11. Licensed operating reactors

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission's monthly LICENSED OPERATING REACTORS Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the Utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  12. Licensed operating reactors

    International Nuclear Information System (INIS)

    The Nuclear Regulatory Commission's annual summary of licensed nuclear power reactor data is based primarily on the report of operating data submitted by licensees for each unit for the month of December because that report contains data for the month of December, the year to date (in this case calendar 1990) and cumulative data, usually from the date of commercial operation. The data is not independently verified, but various computer checks are made. The report is divided into two sections. The first contains summary highlights and the second contains data on each individual unit in commercial operation. Section 1 capacity and availability factors are simple arithmetic averages. Section 2 items in the cumulative column are generally as reported by the licensee and notes as to the use of weighted averages and starting dates other than commercial operation are provided

  13. Licensed operating reactors

    International Nuclear Information System (INIS)

    The Nuclear Regulatory Commissions annual summary of licensed nuclear power reactor data is based primarily on the report of operating data submitted by licensees for each unit for the month of December, the year to date (in this case calendar year 1993) and cumulative data, usually for the date of commercial operation. The data is not independently verified, but various computer checks are made. The report is divided into two sections. The first contains summary highlights and the second contains data on each individual unit in commercial operation. Section 1 capacity and availability factors are simple arithmetic averages. Section 2 items in the cumulative column are generally as reported by the licensee and notes as to the use of weighted averages and starting dates other than commercial operation are provided

  14. Licensed operating reactors

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission's monthly LICENSED OPERATING REACTORS Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  15. Decommissioning licensing procedure

    International Nuclear Information System (INIS)

    Decommissioning or closure of a nuclear power plant, defined as the fact that takes place from the moment that the plant stops producing for the purpose it was built, is causing preocupation. So this specialist meeting on Regulatory Review seems to be the right place for presenting and discusing the need of considering the decommissioning in the safety analysis report. The main goal of this paper related to the licensing procedure is to suggest the need of a new chapter in the Preliminary Safety Analysis Report (P.S.A.R.) dealing with the decommissioning of the nuclear power plant. Therefore, after a brief introduction the problem is exposed from the point of view of nuclear safety and finally a format of the new chapter is proposed. (author)

  16. ESD analog circuits and design

    CERN Document Server

    Voldman, Steven H

    2014-01-01

    A comprehensive and in-depth review of analog circuit layout, schematic architecture, device, power network and ESD design This book will provide a balanced overview of analog circuit design layout, analog circuit schematic development, architecture of chips, and ESD design.  It will start at an introductory level and will bring the reader right up to the state-of-the-art. Two critical design aspects for analog and power integrated circuits are combined. The first design aspect covers analog circuit design techniques to achieve the desired circuit performance. The second and main aspect pres

  17. IRIS Licensing Status

    Energy Technology Data Exchange (ETDEWEB)

    Kling, Charles L.; Carelli, Mario D. [Westinghouse Electric Company, Windsor (United States)

    2006-04-15

    The International Reactor Innovative and Secure (IRIS) nuclear power plant is well into the pre-application review process with the US NRC and has accomplished its first near term goal of obtaining US NRC feedback on the long term testing program. To date, the IRIS team has submitted to the US NRC a number of documents patterned after the Evaluation Model Development and Assessment Process (EMDAP) outlined in Regulatory Guide 1,203. They have covered a detailed description of IRIS, initial safety analysis results, PIRT development for limiting transients, scaling analysis and a description of the test program. The IRIS Safety-by-Desing{sup TM} intrinsically eliminates and/or significantly reduces the consequences of traditional LWR accidents. In addition, the fewer passive safety systems are similar in principle to those of the US NRC approved AP1000 design. For these reasons, the IRIS testing program only needs to include those features unique to the IRIS design. NRC feedback was that the planned test program appeared to be complete and could generate sufficient information to support a Design Certification (DC) submittal. The US NRC has also stated that a DC application must include complete information regarding the test program. On this basis the IRIS team has initiated an aggressive program to conduct IRIS testing to support a DC submittal by the end of 2008. Subsequent US NRC review should be expeditious because of the AP1000 precedent, allowing IRIS to obtain its Final Design Approval (FDA) in 2012; thereby, maintaining its goal of deployment in the 2015-2017 time frame. The next steps in the pre-application review process will be to provide the US NRC with a road map of the anticipated IRIS licensing process, a review of current licensing requirements showing that IRIS meets or exceeds all current criteria and information to support the long term goal of redefining the Emergency Planning Zone (EPZ)

  18. Waste management and licensing

    International Nuclear Information System (INIS)

    It is the Court's consideration of the repercussions the regulation on waste management of Sect. 9a of the Atomic Energy Law will have, relating to the licensing of a plant according to Sect. 7 (2) of the Atomic Energy Law which is noteworthy. Overruling its former legal conception, the Administrative Court Schleswig now assumes, together with the public opinion, that the problem of waste management being brought to a point only with the initial operation of a nuclear power station is accordingly to be taken into account in line with the discretion of licensing according to Sect. 7 (2) of the Atomic Energy Law. In addition, the Administrative Court expressed its opinion on the extent to the right of a neighbour to a nuclear power station to file suit. According to the Sections 114 and 42 (2) of the rules of Administrative Courts it is true that a plaintiff cannot take action to set aside the licence because public interests have not been taken into account sufficiently, but he may do so because his own interests have not been included in the discretionary decision. The Administrative Court is reserved when qualifying the regulation on waste management with regard to the intensity of legal control. The Court is not supposed to replace controversial issues of technology and natural sciences on the part of the executive and its experts by its own assessment. According to the proceedings, the judicial review refers to the finding as to whether decisions made by authorities are suited - according to the way in which they were made - to guarantee the safety standard prescribed in Subdivision 3 of Sect. 7 (2) of the Atomic Energy Law. (HSCH)

  19. Mountain building, from subduction to collision and erosion: insights from 30 years of field and analog modeling studies (Stephan Mueller Medal Lecture)

    Science.gov (United States)

    Malavieille, J.

    2012-04-01

    Through a rapid overview of my research career, I will outline the role of the primary mechanisms and processes, which exert a strong control on mountain building. Field observations (both from structural geology on-land and marine geophysical surveys at sea), and analog modeling are the two main approaches that I used and developed during more than 30 years of research studying mountain belts at Montpellier University. The substantial contributions made through collaborations and exchanges with colleagues and students will be acknowledged. As mountain belts are long lived structures, their evolution involves numerous processes that interact since the early history, beginning during oceanic subduction and ending during the late orogenic evolution which leads to erosion and the ultimate destruction of topography. Most orogens form in subduction settings due to plate convergence involving large horizontal shortening and strong deformation of the crust developing into an overall wedge shape during their evolution. I will focus on orogens caused by subduction of a continental margin lower-plate under an oceanic or continental upper-plate following oceanic subduction, a process also commonly known as collision. After development of a sedimentary accretionary prism and closure of the oceanic domain, continuous subduction of the lithospheric mantle induces deformation of the continental crust and controls the structural asymmetry of the mountain belt. Since the pioneer works by Dahlen, Davis and Suppe in the Eighties, mountain belts have been often considered by geologists as crustal scale accretionary wedges whose deformation mechanisms can be satisfactorily described by a Coulomb behavior. The theory offers a simple mechanical framework allowing a division into different tectonic regimes depending on wedge stability : critical, undercritical, overcritical. Since then, it has been shown that orogens commonly adopt a distinct geometry with a low-tapered pro-wedge facing

  20. Discrete Calculus by Analogy

    CERN Document Server

    Izadi, F A; Bagirov, G

    2009-01-01

    With its origins stretching back several centuries, discrete calculus is now an increasingly central methodology for many problems related to discrete systems and algorithms. The topics covered here usually arise in many branches of science and technology, especially in discrete mathematics, numerical analysis, statistics and probability theory as well as in electrical engineering, but our viewpoint here is that these topics belong to a much more general realm of mathematics; namely calculus and differential equations because of the remarkable analogy of the subject to this branch of mathemati

  1. An analog electronic cochlea

    OpenAIRE

    Lyon, Richard F.; Mead, Carver

    1988-01-01

    An engineered system that hears, such as a speech recognizer, can be designed by modeling the cochlea, or inner ear, and higher levels of the auditory nervous system. To be useful in such a system, a model of the cochlea should incorporate a variety of known effects, such as an asymmetric low-pass/bandpass response at each output channel, a short ringing time, and active adaptation to a wide range of input signal levels. An analog electronic cochlea has been built in CMOS VLSI technolog...

  2. The licensing procedure under Atomic Energy Law

    International Nuclear Information System (INIS)

    This post-doctoral thesis of 1981 has been updated to include developments in this field up to the year 1983. The author discusses in detail all questions relating to the peaceful uses of nuclear energy in the Federal Republic of Germany, predominantly from the point of view of administrative law. He investigates nuclear energy and its contribution to electricity supplies with a view to other energy sources, renewable energy sources, alternative energy policies, nuclear fuel and the fuel cycle, development of the nuclear industry, nuclear power stations in operation, under construction, or in development. Following a survey of the nuclear controversy, both on the national and the international level, the author reviews the legal system and arising controversies in the Federal Republic of Germany, defining the purpose of this thesis to be the systematic analysis of the available legal instruments, in order to show structural deficiencies in the planning law relating to nuclear power stations, and thus reasons of ambiguities within the licensing procedure. The author studies the following terms and requirements: licensing requirements and licensability, the licensing method and scenario, the legal character of licences, their contents and effects within the stepwise procedure, and due publication. (HSCH)

  3. Licensing failure in the European decentralised procedure.

    Science.gov (United States)

    Langedijk, Joris; Ebbers, Hans C; Mantel-Teeuwisse, Aukje K; Kruger-Peters, Alexandra G; Leufkens, Hubert G M

    2016-05-25

    The majority of the licensing applications in the European Union are submitted via the decentralised procedure. Little is known about licensing failure (i.e. refusal or withdrawal of a marketing authorisation application) in the EU decentralised procedure compared to the EU centralised procedure and the approval procedure in the United States. The study aim was to determine the frequency of and determinants for licensing failure of marketing authorisation applications submitted via this procedure. We assessed procedures that failed between 2008 and 2012 with The Netherlands as leading authority and assessed the remaining major objections. In total 492 procedures were completed, of which 48 (9.8%) failed: 8 refused, 40 withdrawn. A wide variety of major objections was identified and included both quality (48 major objections) and clinical (45 major objections) issues. The low failure rate may be related to the regular interaction between competent authorities and applicants during the procedure. Some degree of licensing failure may be inevitable, as it may also be affected by the financial feasibility or willingness to resolve major objections, as well as other reasons to withdraw an application besides the raised major objections. PMID:26493584

  4. Cesium and its analogs, rubidium and potassium, in rhombohedral [NaZr2(PO4)3 type] and cubic (langbeinite type) phosphates: 1. Crystal-chemical studies

    International Nuclear Information System (INIS)

    The published crystallographic data on cesium, rubidium, and potassium phosphates crystallizing in the NaZr2(PO4)3 and langbeinite structural types are summarized and correlated. The existence of new phosphates, analogs of langbeinite mineral, is predicted. The phosphates of the suggested compositions are prepared and studied by X-ray and neutron diffraction and by IR spectroscopy. Phosphates of the formulas A2RZr(PO4)3, A2B0.5Zr1.5(PO4)3, and ABR2(PO4)3 (A = K, Rb, Cs; B = Mg, Sr, Ba; R = La-Nd, Sm-Lu, Fe, Ga) have a cubic cell, space group P213. The nit cell parameters of the phosphates in these series vary only slightly with variation of the cationic composition. Variations in the bond lengths and bond angles in the langbeinite structure depending on the cation are estimated from the results of structural studies. Cesium can be incorporated in cubic framework phosphates in an amount of up to 38 wt %. The langbeinite structure is characterized by wide possibilities of isomorphous substitutions involving large alkali and alkaline-earth metal cations arranged in the framework voids and small cations of p-, d-, and f-block elements in oxidation states 2+, 3+, and 4+, arranged in the framework positions. A specific role of lanthanides in formation of the langbeinite-type framework is noted

  5. Effect of a combined continuous and intermittent transcutaneous electrical nerve stimulation on pain perception of burn patients evaluated by visual analog scale: a pilot study

    Science.gov (United States)

    Pérez-Ruvalcaba, Irma; Sánchez-Hernández, Viridiana; Mercado-Sesma, Arieh R

    2015-01-01

    Aim The aim of this study was to assess the effect of continuous and intermittent electrical transcutaneous nerve stimulation on the perception of pain in patients with burns of different types. Materials and methods A pilot study was conducted in 14 patients (age 30.9±7.5 years) with second- and third-degree burns of different types. The burn types included electrical, fire/flame, and chemical. All patients received continuous and intermittent electrical transcutaneous nerve stimulation sessions three times per week for 4 weeks. Each session had a duration of 30 minutes. A pair of electrodes were placed around the burn. The primary efficacy endpoint was the perception of pain assessed by a visual analog scale at baseline and at the 30th day. Results A significant reduction of pain perception was reported (8.0±1.7 vs 1.0±0.5; P=0.027) by all patients after electrical stimulation therapy. There were no reports of adverse events during the intervention period. Conclusion Electrical stimulation could be a potential nonpharmacological therapeutic option for pain management in burn patients. PMID:26719723

  6. The road to MYRRHA. The pre-licensing phase and FEED

    International Nuclear Information System (INIS)

    The article discusses the study phase of the future research reactor MYRRHA. This study phase covers three major areas: Research and Development, licensing and engineering. In 2013, substantial progress was made in the licensing and engineering processes: licensing is currently in the pre-licensing phase, while, for engineering, the Front-end Engineering and Design (FEED) contract was signed for the construction of the non-nuclear parts of MYRRHA. The article highlights work associated with the the pre-licensing phase and the FEED.

  7. Essays on the economics of licensing nuclear power plants

    International Nuclear Information System (INIS)

    Regulation and licensing of nuclear power plants by the United States Atomic Energy Commission and the United States Nuclear Regulatory Commission are discussed. Chapter 1 overviews the licensing process and issues raised in licensing cases. Based on a sample of plants licensed between 1967 and 1978, a statistical study of the impact of public participation in licensing is performed. The study concludes that public participation has had a major impact on licensing and power-plant costs. The impact is due to a fundamental weakness of the Commissions: their inability to resolve certain issues related to acceptable social risk. The study has important policy implications for reforming the Federal licensing process. Chapter 2 contains an analysis of the Price-Anderson Act, a Federal program for compensating victims of large nuclear accidents. The Price-Anderson Act is placed within the context of generalized federal disaster relief. A model is developed that allows an evaluation programs on the basis of moral hazard and equity principles. Chapter 3 analyzes the Nuclear Regulatory Commission's treatment of its mandatory antitrust review of applicants for nuclear power plants. The main conclusion of the chapter is that the reviews have not addressed the central economic issues of antitrust that are relevant to nuclear power. Instead, the reviews contribute to further cartelization of the electric utility industry. While politically expedient, the reviews are counter-productive to the development of an optimal industry structure

  8. A bilateral frontoparietal network underlies visuospatial analogical reasoning.

    Science.gov (United States)

    Watson, Christine E; Chatterjee, Anjan

    2012-02-01

    Our ability to reason by analogy facilitates problem solving and allows us to communicate ideas efficiently. In this study, we examined the neural correlates of analogical reasoning and, more specifically, the contribution of rostrolateral prefrontal cortex (RLPFC) to reasoning. This area of the brain has been hypothesized to integrate relational information, as in analogy, or the outcomes of subgoals, as in multi-tasking and complex problem solving. Using fMRI, we compared visuospatial analogical reasoning to a control task that was as complex and difficult as the analogies and required the coordination of subgoals but not the integration of relations. We found that analogical reasoning more strongly activated bilateral RLPFC, suggesting that anterior prefrontal cortex is preferentially recruited by the integration of relational knowledge. Consistent with the need for inhibition during analogy, bilateral, and particularly right, inferior frontal gyri were also more active during analogy. Finally, greater activity in bilateral inferior parietal cortex during the analogy task is consistent with recent evidence for the neural basis of spatial relation knowledge. Together, these findings indicate that a network of frontoparietal areas underlies analogical reasoning; we also suggest that hemispheric differences may emerge depending on the visuospatial or verbal/semantic nature of the analogies. PMID:21982934

  9. Study of the photon-induced formation and subsequent desorption of CH3 OH and H2 CO in interstellar ice analogs

    CERN Document Server

    Martín-Doménech, R; Cruz-Díaz, G A

    2016-01-01

    Methanol and formaldehyde are two simple organic molecules that are ubiquitously detected in the interstellar medium. An origin in the solid phase and a subsequent nonthermal desorption into the gas phase is often invoked to explain their abundances in some of the environments where they are found. Experimental simulations under astrophysically relevant conditions have been carried out to find a suitable mechanism for that process. We explore the in situ formation and subsequent photon-induced desorption of these species, studying the UV photoprocessing of pure ethanol ice, and a more realistic binary H2O:CH4 ice analog. Ice samples deposited onto an infrared transparent window at 8 K were UV-irradiated using a microwave-discharged hydrogen flow lamp. Evidence of photochemical production of these two species and subsequent UV-photon-induced desorption into the gas phase were searched for by means of a Fourier transform infrared spectrometer and a quadrupole mass spectrometer, respectively. Formation of CH3OH ...

  10. Application of 4D-QSAR Studies to a Series of Raloxifene Analogs and Design of Potential Selective Estrogen Receptor Modulators

    Directory of Open Access Journals (Sweden)

    Carlos Rangel Rodrigues

    2012-06-01

    Full Text Available Four-dimensional quantitative structure-activity relationship (4D-QSAR analysis was applied on a series of 54 2-arylbenzothiophene derivatives, synthesized by Grese and coworkers, based on raloxifene (an estrogen receptor-alpha antagonist, and evaluated as ERa ligands and as inhibitors of estrogen-stimulated proliferation of MCF-7 breast cancer cells. The conformations of each analogue, sampled from a molecular dynamics simulation, were placed in a grid cell lattice according to three trial alignments, considering two grid cell sizes (1.0 and 2.0 Å. The QSAR equations, generated by a combined scheme of genetic algorithms (GA and partial least squares (PLS regression, were evaluated by “leave-one-out” cross-validation, using a training set of 41 compounds. External validation was performed using a test set of 13 compounds. The obtained 4D-QSAR models are in agreement with the proposed mechanism of action for raloxifene. This study allowed a quantitative prediction of compounds’ potency and supported the design of new raloxifene analogs.

  11. In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations.

    Science.gov (United States)

    Gao, Xiaodong; Han, Liping; Ren, Yujie

    2016-01-01

    Checkpoint kinase 1 (Chk1) is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling, molecular docking, and molecular dynamics simulations. The optimal QSAR models showed significant cross-validated correlation q² values (0.531, 0.726), fitted correlation r² coefficients (higher than 0.90), and standard error of prediction (less than 0.250). These results suggested that the developed models possess good predictive ability. Moreover, molecular docking and molecular dynamics simulations were applied to highlight the important interactions between the ligand and the Chk1 receptor protein. This study shows that hydrogen bonding and electrostatic forces are key interactions that confer bioactivity. PMID:27164065

  12. In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations

    Directory of Open Access Journals (Sweden)

    Xiaodong Gao

    2016-05-01

    Full Text Available Checkpoint kinase 1 (Chk1 is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative structure–activity relationship (3D-QSAR modeling, molecular docking, and molecular dynamics simulations. The optimal QSAR models showed significant cross-validated correlation q2 values (0.531, 0.726, fitted correlation r2 coefficients (higher than 0.90, and standard error of prediction (less than 0.250. These results suggested that the developed models possess good predictive ability. Moreover, molecular docking and molecular dynamics simulations were applied to highlight the important interactions between the ligand and the Chk1 receptor protein. This study shows that hydrogen bonding and electrostatic forces are key interactions that confer bioactivity.

  13. Importance of the tryptophans of gramicidin for its lipid structure modulating activity in lysophosphatidylcholine and phosphatidylethanolamine model membranes. A comparative study employing gramicidin analogs and a synthetic α-helical hydrophobic polypeptide

    NARCIS (Netherlands)

    Aranda, F.J.; Killian, J.A.; Kruijff, B. de

    1987-01-01

    The importance of the tryptophan residues of gramicidin for the lipid structure modulating activity of this pentadecapeptide was investigated by studying the interaction of gramicidin analogs A, B, C (which have a tryptophan, phenylalanine and tyrosine in position 11, respectively) and tryptophan-N-

  14. Harmonisation of licensing processes for decommissioning. Options and limitations

    International Nuclear Information System (INIS)

    The shutdown of eight reactors in Germany in the wake of Fukushima 2011 and the scheduled phase-out of the remaining units in several steps ending 2022 has obviously triggered a wave of applications for decommissioning and dismantling licences. It would seem natural to strive for a harmonised handling of these processes, analogous to the 'convoi' concept which was successfully employed for licensing and construction of the three most recent German NPPs in the 1980s. However, a comparative analysis shows that the motivation of all players is much different from that of earlier times and that harmonisation of licensing processes for dismantling is not as crucial for operators, authorities and technical support organisations as it was for construction.

  15. Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluation

    International Nuclear Information System (INIS)

    Introduction: The aim of the study was to compare in vitro and in vivo a novel DOTA-chelated bombesin (BN) analog of the amino acid sequence, QRLGNQWAVGHLM-CONH2 (BN[2-14]NH2), labeled with 90Y and 177Lu, for its potential use in targeted radiotherapy of tumors expressing gastrin releasing peptide (GRP) receptors. The same amino acid sequence, but with different chelator, referred as BN1.1 (Gly-Gly-Cys-Aca-QRLGNQWAVGHLM-CONH2), has already been studied and reported; however, the DOTA-chelated one, suitable for labeling with M+3 type radiometals, was not yet described. Methods: The conditions for labeling of DOTA-BN[2-14]NH2 with noncarrier added 90Y and with 177Lu [specific activity (SA), 15 Ci/mg Lu] were investigated and optimized to provide 90Y-DOTA-BN[2-14]NH2 and 177Lu-DOTA-BN[2-14]NH2 of high SA. The stability of the radiolabeled compounds in human serum was evaluated over a period of 24 h. The human prostate cancer cell line PC-3, known to express GRP receptors, was used for in vitro evaluation of radiolabeled peptide affinity to GRP receptors and for assessment of cytotoxicity of both nonlabeled and radiolabeled peptide. Biodistribution accompanied by receptor blocking was studied in normal Swiss mice. Results: 90Y-DOTA-BN[2-14]NH2 and 177Lu-DOTA-BN[2-14]NH2 were obtained with radiochemical yield >98% and high SA (67.3 GBq 90Y/μmol and 33.6 GBq 177Lu/μmol, respectively). They were stable when incubated in human serum for up to 24 h. The binding affinities of DOTA-BN[2-14]NH2 and both natY- and natLu-labeled analogs to GRP receptors were high (IC50=1.78, 1.99, and 1.34 nM, respectively), especially for the natLu-DOTA-BN[2-14]NH2 complex. The cytotoxicity study of DOTA-BN[2-14]NH2 to PC-3 cells revealed an IC50=6300 nM after 72 h of exposition, while the labeled derivatives showed no significant cytotoxic effect. The internalization rate to PC-3 cells was more rapid for 177Lu-labeled peptide (84.87%) than for the 90Y-labeled one (80.79%), while the efflux

  16. Approaches to synthetic platelet analogs.

    Science.gov (United States)

    Modery-Pawlowski, Christa L; Tian, Lewis L; Pan, Victor; McCrae, Keith R; Mitragotri, Samir; Sen Gupta, Anirban

    2013-01-01

    Platelet transfusion is routinely used for treating bleeding complications in patients with hematologic or oncologic clotting disorders, chemo/radiotherapy-induced myelosuppression, trauma and surgery. Currently, these transfusions mostly use allogeneic platelet concentrates, while products like lyophilized platelets, cold-stored platelets and infusible platelet membranes are under investigation. These natural platelet-based products pose considerable risks of contamination, resulting in short shelf-life (3-5 days). Recent advances in pathogen reduction technologies have increased shelf-life to ~7 days. Furthermore, natural platelets are short in supply and also cause several biological side effects. Hence, there is significant clinical interest in platelet-mimetic synthetic analogs that can allow long storage-life and minimum side effects. Accordingly, several designs have been studied which decorate synthetic particles with motifs that promote platelet-mimetic adhesion or aggregation. Recent refinement in this design involves combining the adhesion and aggregation functionalities on a single particle platform. Further refinement is being focused on constructing particles that also mimic natural platelet's shape, size and elasticity, to influence margination and wall-interaction. The optimum design of a synthetic platelet analog would require efficient integration of platelet's physico-mechanical properties and biological functionalities. We present a comprehensive review of these approaches and provide our opinion regarding the future directions of this research. PMID:23092864

  17. 3~11岁儿童类比推理发展的研究%3~11Years Old Children’s Analogical Reasoning:A Developmental Study

    Institute of Scientific and Technical Information of China (English)

    费广洪; 王淑娟

    2014-01-01

    该研究随机抽取180名3~11岁儿童,采用几何图形、关系图形、词语、数字、故事五种材料,考察儿童类比推理发展的年龄特点和规律。结果发现:(1)4~5岁儿童开始能够进行类比推理,类比推理随年龄的增长逐渐发展,呈上升趋势;(2)儿童类比推理的发展表现出阶段性的特点;(3)儿童类比推理的发展不受材料影响,具有一定稳定性;(4)小学高年级儿童类比推理发展水平较高,学前儿童水平较低。%This study randomly selected 180 children aged 3~11,used five kinds of materials including geometry,relations graphics, word,number and story to investigate the age characteristic of the children’s analogical reasoning development. The results showed that:(1)4~5 years old children began to be able to analogize and the ability of analogical reasoning gradually developed along with the growth of the age.(2)The development of children’s analogical reasoning showed the characteristic of stage 4~11 years old children’ s analogical reasoning development can be divided into four stages.(3)The development of children’s analogical reasoning is not affect-ed by materials,has certain stability.(4)The developmental level of elementary school higher grade children’s in analogical reasoning is higher but the developmental level of pre-school children’s in analogical reasoning is lower.

  18. Vorticity in analog gravity

    Science.gov (United States)

    Cropp, Bethan; Liberati, Stefano; Turcati, Rodrigo

    2016-06-01

    In the analog gravity framework, the acoustic disturbances in a moving fluid can be described by an equation of motion identical to a relativistic scalar massless field propagating in curved space-time. This description is possible only when the fluid under consideration is barotropic, inviscid, and irrotational. In this case, the propagation of the perturbations is governed by an acoustic metric that depends algebrically on the local speed of sound, density, and the background flow velocity, the latter assumed to be vorticity-free. In this work we provide a straightforward extension in order to go beyond the irrotational constraint. Using a charged—relativistic and nonrelativistic—Bose–Einstein condensate as a physical system, we show that in the low-momentum limit and performing the eikonal approximation we can derive a d’Alembertian equation of motion for the charged phonons where the emergent acoustic metric depends on flow velocity in the presence of vorticity.

  19. Feedback in analog circuits

    CERN Document Server

    Ochoa, Agustin

    2016-01-01

    This book describes a consistent and direct methodology to the analysis and design of analog circuits with particular application to circuits containing feedback. The analysis and design of circuits containing feedback is generally presented by either following a series of examples where each circuit is simplified through the use of insight or experience (someone else’s), or a complete nodal-matrix analysis generating lots of algebra. Neither of these approaches leads to gaining insight into the design process easily. The author develops a systematic approach to circuit analysis, the Driving Point Impedance and Signal Flow Graphs (DPI/SFG) method that does not require a-priori insight to the circuit being considered and results in factored analysis supporting the design function. This approach enables designers to account fully for loading and the bi-directional nature of elements both in the feedback path and in the amplifier itself, properties many times assumed negligible and ignored. Feedback circuits a...

  20. Licensed operating reactors

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission's monthly LICENSED OPERATING REACTORS Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. Since all of the data concerning operation of the units is provided by the utility operators less than two weeks after the end of the month, necessary corrections to published information are shown on the ERRATA page. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the Utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  1. License restrictions at Barnwell

    Energy Technology Data Exchange (ETDEWEB)

    Autry, V.R. [S.C. Dept. of Health and Environmental Control, Columbia, SC (United States). Bureau of Radiological Health

    1991-12-31

    The State of South Carolina was delegated the authority by the US Nuclear Regulatory Commission to regulate the receipt, possession, use and disposal of radioactive material as an Agreement State. Since 1970, the state has been the principal regulatory authority for the Barnwell Low-Level Waste Disposal Facility operated by Chem-Nuclear Systems, Inc. The radioactive material license issued authorizing the receipt and disposal of low-level waste contains numerous restrictions to ensure environmental protection and compliance with shallow land disposal performance criteria. Low-level waste has evolved from minimally contaminated items to complex waste streams containing high concentrations of radionuclides and processing chemicals which necessitated these restrictions. Additionally, some waste with their specific radionuclides and concentration levels, many classified as low-level radioactive waste, are not appropriate for shallow land disposal unless additional precautions are taken. This paper will represent a number of these restrictions, the rationale for them, and how they are being dealt with at the Barnwell disposal facility.

  2. Licensed operating reactors

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission's monthly LICENSED OPERATING REACTORS Status Summary Report provides data on the operation of nuclear units as timely and accurately as possible. This information is collected by the Office of Information Resources Management, from the Headquarters Staff of NRC's Office of Inspection and Enforcement, from NRC's Regional Offices, and from utilities. Since all of the data concerning operation of the units are provided by the utility operators less than two weeks after the end of the month, necessary corrections to published information are shown on the ERRATA page. This report is divided into three sections: the first contains monthly highlights and statistics for commercial operating units, and errata from previously reported data; the second is a compilation of detailed information on each unit, provided by NRC Regional Offices, IE Headquarters and the Utilities; and the third section is an appendix for miscellaneous information such as spent fuel storage capability, reactor years of experience and non-power reactors in the United States

  3. VEHICLES LICENSED IN SWITZERLAND

    CERN Multimedia

    Service des Relations avec les Pays-Hôtes

    2000-01-01

    1.\tVehicle licensinga)\tTime limitsVehicles must have a Swiss registration document and Swiss number plates: -\tif the owner has been residing in Switzerland for more than one year without a break of more than three consecutive months and has been using it for more than one month on Swiss territory, or -\tif the vehicle itself has been on Swiss territory for more than one year without a break of more than three consecutive months. b)\tTechnical details Vehicles belonging to non-Swiss members of the personnel who hold a carte de légitimation issued by the Swiss Federal Department of Foreign Affairs (hereinafter referred to as 'DFAE') and who were not permanently resident in Switzerland before taking up their appointment may be licensed in Switzerland with virtually no restrictions provided that their owner produces: -\tthe vehicle registration document and number plates of the country in which the car was previously registered, or -\ta manufacturer's certi...

  4. CANDU 9 enhancements and licensing

    International Nuclear Information System (INIS)

    The CANDU 9 design has followed the evolutionary product development approach that has characterized the CANDU family of nuclear power plants. In addition to utilizing proven equipment and systems from operating stations, the CANDU 9 design has looked ahead to incorporate design and safety enhancements necessary to meet evolving utility and licensing requirements. With the requirement that the CANDU 9 design should be licensable for both domestic and foreign potential users, the pre-project Basic Design Engineering program included a two year formal extensive review by the Canadian Regulatory Agency, the Atomic Energy Control Board . Documentation submitted for the licensing review included the licensing basis, safety requirements and safety analyses necessary to demonstrate compliance with regulations and to assess system design and performance

  5. 10 CFR 50.52 - Combining licenses.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Combining licenses. 50.52 Section 50.52 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Issuance, Limitations, and Conditions of Licenses and Construction Permits § 50.52 Combining licenses. The Commission may combine in...

  6. Analogy-Based Expectation Equilibrium

    OpenAIRE

    Jehiel, P

    2001-01-01

    It is assumed that players bundle nodes in which other players must move into analogy classes, and players only have expectations about the average behavior in every class. A solution concept is proposed for multi-stage games with perfect information: at every node players choose best-responses to their analogy-based expectations, and expectations are correct on average over those various nodes pooled together into the same analogy classes. The approach is applied to a variety of games. It is...

  7. Beginning analog electronics through projects

    CERN Document Server

    Singmin, Andrew

    2001-01-01

    Analog electronics is the simplest way to start a fun, informative, learning program. Beginning Analog Electronics Through Projects, Second Edition was written with the needs of beginning hobbyists and students in mind. This revision of Andrew Singmin's popular Beginning Electronics Through Projects provides practical exercises, building techniques, and ideas for useful electronics projects. Additionally, it features new material on analog and digital electronics, and new projects for troubleshooting test equipment.Published in the tradition of Beginning Electronics Through Projects an

  8. Analog and digital signal processing

    Science.gov (United States)

    Baher, H.

    The techniques of signal processing in both the analog and digital domains are addressed in a fashion suitable for undergraduate courses in modern electrical engineering. The topics considered include: spectral analysis of continuous and discrete signals, analysis of continuous and discrete systems and networks using transform methods, design of analog and digital filters, digitization of analog signals, power spectrum estimation of stochastic signals, FFT algorithms, finite word-length effects in digital signal processes, linear estimation, and adaptive filtering.

  9. New Insight into the Nature of Bonding in the Dimers of Lappert's Stannylene and Its Ge Analogs: A Quantum Mechanical Study.

    Science.gov (United States)

    Sedlak, Robert; Stasyuk, Olga A; Fonseca Guerra, Célia; Řezáč, Jan; Růžička, Aleš; Hobza, Pavel

    2016-04-12

    The strength and nature of the connection in Lappert's stannylene dimer ({Sn[CH(SiMe3)2]2}2) and its smaller analogs, simplified stannylenes, as well as similar Ge complexes were studied by means of DFT-D3 calculations, energy decomposition analysis (EDA), electrostatic potential (ESP), and natural population analysis. The trans-bent structure of the investigated molecules was rationalized by means of EDA, ESP, and molecular orbital (MO) analyses. The different ESPs for the monomers studied are a result of different hybridization of the Sn (Ge) atoms. The comparably strong stabilization in the largest and the smallest systems with a dramatically different substituent size is explained by the different nature of the binding between monomers. For all complexes, it has been found that the total attractive interaction is mostly provided by the electrostatic component (>50%), followed by orbital interaction and dispersion. In the largest molecule (Lappert's stannylene), the dispersion interaction plays a more significant role in stabilization and its magnitude is comparable to that of orbital interaction; on the other hand in the smallest molecule (SnH2), where bulky substituents are replaced by H only, the dispersion energy is less important and the E-E bond is more of a charge-transfer character, caused by donor-acceptor orbital interactions. The charge transfer in Ge dimers is greater than in the Sn ones due to shorter distances between monomers, which cause better ⟨HOMO/LUMO⟩ overlaps. The easier dimerization of Lappert's stannylene as compared to Kira's ({Sn[(Me3Si)2CHCH2CH2CH(SiMe3)2-κ(2)C,C']}) stannylene is explained by the different orientation of their substituents-asymmetry promotes dimerization. PMID:26953594

  10. Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies.

    Science.gov (United States)

    Drzezga, A; Darsow, U; Treede, R D; Siebner, H; Frisch, M; Munz, F; Weilke, F; Ring, J; Schwaiger, M; Bartenstein, P

    2001-05-01

    The aim of this study was to identify the functional cerebral network involved in the central processing of itch and to detect analogies and differences to previously identified cerebral activation patterns triggered by painful noxious stimuli. Repeated positron emission tomography regional cerebral blood flow (rCBF) measurements using O15-labeled water were performed in six healthy right-handed male subjects (mean age 32 +/- 2 years). Each subject underwent 12 sequential rCBF measurements. In all subjects a standardized skin prick test was performed on the right forearm 2 min before each rCBF measurement. For activation, histamine was applied in nine tests in logarithmically increasing concentrations from 0.03 to 8%. Three tests were performed with isotonic saline solution serving as a control condition. Itch intensity and unpleasantness were registered with a visual analogue scale during each test. Subtraction analysis between activation and control conditions as well as correlation analysis with covariates were performed. Itch induced a significant activation in the predominantly contralateral somatosensory cortex and in the ipsilateral and contralateral motor areas (supplementary motor area (SMA), premotor cortex, primary motor cortex). Additional significant activations were found in the prefrontal cortex and the cingulate gyrus, but not in subcortical structures nor in the secondary somatosensory cortex. In correlation analyses, several cortical areas showed a graded increase in rCBF with the logarithm of the histamine concentration (bilateral sensorimotor areas and cingulate cortex; contralateral insula, superior temporal cortex and prefrontal cortex) and with itch unpleasantness (contralateral sensorimotor cortex, prefrontal cortex and posterior insula; ipsilateral SMA). Induction of itch results in the activation of a distributed cerebral network. Itch and pain seem to share common pathways (a medial and a lateral processing pathway and a strong projection

  11. Effect of a combined continuous and intermittent transcutaneous electrical nerve stimulation on pain perception of burn patients evaluated by visual analog scale: a pilot study

    Directory of Open Access Journals (Sweden)

    Pérez-Ruvalcaba I

    2015-12-01

    Full Text Available Irma Pérez-Ruvalcaba,1 Viridiana Sánchez-Hernández,1 Arieh R Mercado-Sesma2,3 1Burn Unit, Hospital de Especialidades, Centro Médico Nacional de Occidente, Mexican Institute of Social Security, 2Health Sciences Department, Centro Universitario de Tonalá, University of Guadalajara, Guadalajara, Mexico; 3Diabetes sin Complicaciones, Zapopan, Mexico Aim: The aim of this study was to assess the effect of continuous and intermittent electrical transcutaneous nerve stimulation on the perception of pain in patients with burns of different types. Materials and methods: A pilot study was conducted in 14 patients (age 30.9±7.5 years with second- and third-degree burns of different types. The burn types included electrical, fire/flame, and chemical. All patients received continuous and intermittent electrical transcutaneous nerve stimulation sessions three times per week for 4 weeks. Each session had a duration of 30 minutes. A pair of electrodes were placed around the burn. The primary efficacy endpoint was the perception of pain assessed by a visual analog scale at baseline and at the 30th day. Results: A significant reduction of pain perception was reported (8.0±1.7 vs 1.0±0.5; P=0.027 by all patients after electrical stimulation therapy. There were no reports of adverse events during the intervention period. Conclusion: Electrical stimulation could be a potential nonpharmacological therapeutic option for pain management in burn patients. Keywords: TENS, burn pain, pain management, electrotherapy

  12. Unionization Structure, Licensing and Innovation

    OpenAIRE

    Mukherjee, Arijit; Pennings, Enrico

    2005-01-01

    This discussion paper led to a publication in the 'International Journal of Industrial Organization', 29(2), 232-41.Taking technological differences between firms as given, we show that the technologically advanced firm has a stronger incentive for technology licensing under a decentralized unionization structure than with centralized wage setting. Furthermore, We show that, in presence of licensing, the incentive for innovation may also be stronger under decentralized unions. Unions have a c...

  13. 7 CFR 51.34 - Suspension or revocation of license of a licensed inspector.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Suspension or revocation of license of a licensed... revocation of license of a licensed inspector. Pending final action by the Secretary, the Administrator may..., supported by any argument or evidence that he may wish to offer as to why his license should not...

  14. Evaluation of Terminated Nuclear Material Licenses

    International Nuclear Information System (INIS)

    This report presents the results of a six-year project that reviewed material licenses that had been terminated during the period from inception of licensing until approximately late-1994. The material licenses covered in the review project were Part 30, byproduct material licenses; Part 40, source material licenses; and Part 70, special nuclear material licenses. This report describes the methodology developed for the project, summarizes the findings of the license file inventory process, and describes the findings of the reviews or evaluations of the license files. The evaluation identified nuclear material use sites that need review of the licensing material or more direct follow-up of some type. The review process also identified licenses authorized to possess sealed sources for which there was incomplete or missing documentation of the fate of the sources

  15. US licensing process and ABWR certification

    International Nuclear Information System (INIS)

    The Part 50 licensing process establishes a two-step licensing process whereby the U.S. Nuclear Regulatory Commission (NRC) authorizes construction through issuance of a construction permit and authorizes operation by issuance of an operating license. At each stage, the NRC staff conducts technical reviews, and there is potential for public hearings. The purpose of the Part 52 licensing process is to provide a regulatory framework that brings about early resolution of licensing issues in comparison with the Part 50 process. Because issues are not resolved early in the Part 50 licensing process, approval of an operating license is not assured until after a significant investment has been made in the plant. Part 52 increases the stability and certainty of the licensing process by providing for the early resolution of safety and environmental issues. The Part 52 licensing process features early site permits, design certification, and combined construction permits and operating licenses

  16. Electronic devices for analog signal processing

    CERN Document Server

    Rybin, Yu K

    2012-01-01

    Electronic Devices for Analog Signal Processing is intended for engineers and post graduates and considers electronic devices applied to process analog signals in instrument making, automation, measurements, and other branches of technology. They perform various transformations of electrical signals: scaling, integration, logarithming, etc. The need in their deeper study is caused, on the one hand, by the extension of the forms of the input signal and increasing accuracy and performance of such devices, and on the other hand, new devices constantly emerge and are already widely used in practice, but no information about them are written in books on electronics. The basic approach of presenting the material in Electronic Devices for Analog Signal Processing can be formulated as follows: the study with help from self-education. While divided into seven chapters, each chapter contains theoretical material, examples of practical problems, questions and tests. The most difficult questions are marked by a diamon...

  17. Learning-by-Licensing: How Chinese Firms Benefit From Licensing-In Technologies

    DEFF Research Database (Denmark)

    Wang, Yuandi; Roijakkers, N.; Vanhaverbeke, W.

    2012-01-01

    performance lies in differences of absorptive capacity. In this study, we intend to relax this assumption and use data about 186 Chinese indigenous firms to investigate how differences in in-licensing portfolios lead to different effects on innovation performance. We find that firms benefit from prior in...

  18. COMPARISON OF CERTAIN ABILITIES NEEDED BY WORKERS IN LICENSED NURSERIES AND LICENSED ORNAMENTAL HORTICULTURE BUSINESSES.

    Science.gov (United States)

    DILLON, ROY D.

    THIS STUDY WAS CONDUCTED TO DETERMINE THE EXTENT TO WHICH WORKERS WITH THE JOB TITLES OF GENERAL DIRECTORS, SALESMEN, SUPERVISORS, AND FIELD WORKERS IN LICENSED NURSERIES NEEDED AGRICULTURALLY ORIENTED KNOWLEDGE OF THE SAME KIND AND LEVEL AS WORKERS IN COMPARABLE JOB TITLES IN ORNAMENTAL HORTICULTURE BUSINESSES. DATA WERE COLLECTED BY PERSONAL…

  19. AN EVALUATIONOF LICENSE PLATE RECOGNITION ALGORITHMS

    Directory of Open Access Journals (Sweden)

    Hadi Sharifi Kolour

    2011-01-01

    Full Text Available In the last decades vehicle license plate recognition systems are as central part in many traffic management and security systems such as automatic speed control, tracking stolen cars, automatic toll management, and access control to limited areas. There are many techniques for license plate detection. The goal of this paper is study and evaluate some most important LPD algorithms and compared them in terms of accuracy, performance, complexity, and their usefulness in different environmental condition. This evaluation gives views to the developers or end-users to choose the most appropriate technique for their applications. Our study and investigation show that the dynamic programming algorithm is the fastest and the Gabor transform is the most accuracy algorithm compared to other algorithms.

  20. Study of proton radiation effects on analog IC designed for high energy physics in a BICMOS-JFET Radhard SOI technology

    International Nuclear Information System (INIS)

    We present results from a fast charge amplifier and a wideband analog buffer fabricated in a BiCMOS-JFET Radhard SOI technology and irradiated up to 4.5 1014 protons/cm2. Simulations using main parameters from irradiated components fit roughly these results. (authors). 6 refs., 6 figs

  1. Natural Analogs for the Unsaturated Zone

    International Nuclear Information System (INIS)

    The purpose of this Analysis/Model Report (AMR) is to document natural and anthropogenic (human-induced) analog sites and processes that are applicable to flow and transport processes expected to occur at the potential Yucca Mountain repository in order to build increased confidence in modeling processes of Unsaturated Zone (UZ) flow and transport. This AMR was prepared in accordance with ''AMR Development Plan for U0135, Natural Analogs for the UZ'' (CRWMS 1999a). Knowledge from analog sites and processes is used as corroborating information to test and build confidence in flow and transport models of Yucca Mountain, Nevada. This AMR supports the Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR) and the Yucca Mountain Site Description. The objectives of this AMR are to test and build confidence in the representation of UZ processes in numerical models utilized in the UZ Flow and Transport Model. This is accomplished by: (1) applying data from Boxy Canyon, Idaho in simulations of UZ flow using the same methodologies incorporated in the Yucca Mountain UZ Flow and Transport Model to assess the fracture-matrix interaction conceptual model; (2) Providing a preliminary basis for analysis of radionuclide transport at Pena Blanca, Mexico as an analog of radionuclide transport at Yucca Mountain; and (3) Synthesizing existing information from natural analog studies to provide corroborating evidence for representation of ambient and thermally coupled UZ flow and transport processes in the UZ Model

  2. NaturAnalogs for the Unsaturated Zone

    Energy Technology Data Exchange (ETDEWEB)

    A. Simmons; A. Unger; M. Murrell

    2000-03-08

    The purpose of this Analysis/Model Report (AMR) is to document natural and anthropogenic (human-induced) analog sites and processes that are applicable to flow and transport processes expected to occur at the potential Yucca Mountain repository in order to build increased confidence in modeling processes of Unsaturated Zone (UZ) flow and transport. This AMR was prepared in accordance with ''AMR Development Plan for U0135, Natural Analogs for the UZ'' (CRWMS 1999a). Knowledge from analog sites and processes is used as corroborating information to test and build confidence in flow and transport models of Yucca Mountain, Nevada. This AMR supports the Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR) and the Yucca Mountain Site Description. The objectives of this AMR are to test and build confidence in the representation of UZ processes in numerical models utilized in the UZ Flow and Transport Model. This is accomplished by: (1) applying data from Boxy Canyon, Idaho in simulations of UZ flow using the same methodologies incorporated in the Yucca Mountain UZ Flow and Transport Model to assess the fracture-matrix interaction conceptual model; (2) Providing a preliminary basis for analysis of radionuclide transport at Pena Blanca, Mexico as an analog of radionuclide transport at Yucca Mountain; and (3) Synthesizing existing information from natural analog studies to provide corroborating evidence for representation of ambient and thermally coupled UZ flow and transport processes in the UZ Model.

  3. A Bilateral Frontoparietal Network Underlies Visuospatial Analogical Reasoning

    OpenAIRE

    Watson, Christine E.; Chatterjee, Anjan

    2011-01-01

    Our ability to reason by analogy facilitates problem solving and allows us to communicate ideas efficiently. In this study, we examined the neural correlates of analogical reasoning and, more specifically, the contribution of rostrolateral prefrontal cortex (RLPFC) to reasoning. This area of the brain has been hypothesized to integrate relational information, as in analogy, or the outcomes of subgoals, as in multi-tasking and complex problem solving. Using fMRI, we compared visuospatial analo...

  4. The analogic model ''RIC'' of thermal behaviour of mass concrete

    International Nuclear Information System (INIS)

    In order to study the thermal field and calorific flows in heat sources (i.e. mass concrete during setting) we have conceived, built and experimented with an analogical electric model. This model, named RIC, consists of resistors (R) and capacitors (C) in which nodes an electric current (I) has been injected. Several analogical constants were used for the mathematical approximation. Thus, this paper describes the analogical RIC model, simulating heat generation, boundary and initial conditions and concreting. (Author) 4 refs

  5. The future of vitamin D analogs

    Directory of Open Access Journals (Sweden)

    Carlien eLeyssens

    2014-04-01

    Full Text Available The active form of vitamin D3, 1,25-dihydroxyvitamin D3, is a major regulator of bone and calcium homeostasis. In addition, this hormone also inhibits the proliferation and stimulates the differentiation of normal as well as malignant cells. Supraphysiological doses of 1,25-dihydroxyvitamin D3 are required to reduce cancer cell proliferation. However, these doses will lead in vivo to calcemic side effects such as hypercalcemia and hypercalciuria. During the last 25 years, many structural analogs of 1,25-dihydroxyvitamin D3 have been synthesized by the introduction of chemical modifications in the A-ring, central CD-ring region or side chain of 1,25-dihydroxyvitamin D3 in the hope to find molecules with a clear dissociation between the beneficial antiproliferative effects and adverse calcemic side effects. One example of such an analog with a good dissociation ratio is calcipotriol (DaivonexR, which is clinically used to treat the hyperproliferative skin disease psoriasis. Other vitamin D analogs were clinically approved for the treatment of osteoporosis or secondary hyperparathyroidism. No vitamin D analog is currently used in the clinic for the treatment of cancer although several analogs have been shown to be potent drugs in animal models of cancer. Omics studies as well as in vitro cell biological experiments unraveled basic mechanisms involved in the antineoplastic effects of vitamin D and its analogs. 1,25-dihydroxyvitamin D3 and analogs act in a cell type- and tissue-specific manner. Moreover, a blockade in the transition of the G0/1 towards S phase of the cell cycle, induction of apoptosis, inhibition of migration and invasion of tumor cells together with effects on angiogenesis and inflammation have been implicated in the pleiotropic effects of 1,25-dihydroxyvitamin D3 and its analogs. In this review we will give an overview of the action of vitamin D analogs in tumor cells and look forward how these compounds could be introduced in the

  6. Generic environmental impact statement for license renewal of nuclear plants

    International Nuclear Information System (INIS)

    Volume 2 of the Generic Environmental Impact Statement for License Renewal of Nuclear Plants contains the appendices. These include: (A) General characterisitics and environmental settings of domestic nuclear plants, (B) Definition of impact initiators, (C) Socioeconomics and case studies, (D) Aquatic organisms and human health, (E) Radiation protection considerations, (F) Methodology for assessing impacts to aquatic ecology and water resources, (G) Postulated accidents, and (H) Environmental statutes and regulations affecting license renewal

  7. Isolated transfer of analog signals

    Science.gov (United States)

    Bezdek, T.

    1974-01-01

    Technique transfers analog signal levels across high isolation boundary without circuit performance being affected by magnetizing reactance or leakage inductance. Transfers of analog information across isolated boundary are made by interrupting signal flow, with switch, in such a manner as to produce alternating signal which is applied to transformer.

  8. Drawing Analogies in Environmental Education

    Science.gov (United States)

    Affifi, Ramsey

    2014-01-01

    Reconsidering the origin, process, and outcomes of analogy-making suggests practices for environmental educators who strive to disengage humans from the isolating illusions of dichotomizing frameworks. We can view analogies as outcomes of developmental processes within which human subjectivity is but an element, threading our sense of self back…

  9. Analog elements for transuranic chemistries

    International Nuclear Information System (INIS)

    A chemical extraction technique for estimating the biologically available fraction of nonessential trace elements in soils has been developed. This procedure has been used in evaluating the uptake of naturally occurring transuranic analog elements from soils into several foodstuffs. The availability of the natural elements has been compared with the availability of their analog transuranics which have been derived from global fallout

  10. Doing mathematics convention, subject, calculation, analogy

    CERN Document Server

    Krieger, Martin H

    2003-01-01

    This book discusses some ways of doing mathematical work and the subject matter that is being worked upon and created. It argues that the conventions we adopt, the subject areas we delimit, what we can prove and calculate about the physical world, and the analogies that work for mathematicians - all depend on mathematics, what will work out and what won't. And the mathematics, as it is done, is shaped and supported, or not, by convention, subject matter, calculation, and analogy. The cases studied include the central limit theorem of statistics, the sound of the shape of a drum, the connection

  11. Importance of the tryptophans of gramicidin for its lipid structure modulating activity in lysophosphatidylcholine and phosphatidylethanolamine model membranes. A comparative study employing gramicidin analogs and a synthetic α-helical hydrophobic polypeptide

    OpenAIRE

    Aranda, F J; Killian, J A; Kruijff, B. de

    1987-01-01

    The importance of the tryptophan residues of gramicidin for the lipid structure modulating activity of this pentadecapeptide was investigated by studying the interaction of gramicidin analogs A, B, C (which have a tryptophan, phenylalanine and tyrosine in position 11, respectively) and tryptophan-N-formylated gramicidin (in which the four tryptophan residues have been formylated) with several phospholipid systems. In addition in α-helical model pentadecapeptide (P15) was studied to further te...

  12. Development of licensing process for SMART-P

    International Nuclear Information System (INIS)

    The basic design of System-integrated Modular Advanced Reactor (SMART), a small-to-medium sized integral type pressurized water reactor (PWR) with the capacity of 330MWth, has been developed in Korea. Presently, for the purpose of demonstrating the safety and performance of the SMART design, 'Development Project of SMART-P (SMART-Pilot Plant)' is being performed as one of the 'National Mid and Long-term Atomic Energy R and D Programs', which includes design, construction, and start-up operation of the SMART-P with the capacity of 65MWth, a 1/5 scaled-down design of the SMART. At the same time, a study on the establishment of a licensing process for the SMART-P has been carried out by KINS in order to prepare for the forthcoming SMART-P licensing. The results of this study performed from Aug. of 2002 to June of 2004 can be summarized as follows: (1) The construction purpose and design characteristics of the SMRAT-P were reviewed. (2) The licensing processes for reactors in Korea, U.S.A., Japan, France, U.K., Canada, and IAEA were analyzed. (3) Reactor classification criteria were established based on the analysis results for the foreign licensing processes. And a development direction for the licensing process applicable to the development reactor was established. (4) 4 candidate models of licensing process for the development reactor were proposed based on the domestic licensing processes considering the general trends and practices of the foreign licensing processes. Evaluation of the candidate models were performed. (5) Through the expert review of the candidate models, an optimized model was finally selected and an implementation plan for the optimized model including legalization was established. The licensing process for the development reactor proposed in this study can be applied directly to the licensing of the SMART-P. Furthermore, it will be also applied to the licensing of the development reactors for the advanced reactors such as the GEN-IV

  13. Experiments of analog states on Lead 206 and 207

    International Nuclear Information System (INIS)

    This research thesis aims at verifying hypotheses according to which the spread of analog states decreases as much as nuclei are far from a double magic nucleus, under some conditions. Therefore, analog states of lead 207 and 208 have been studied by proton scattering on targets in lead 206 and 207. Some theoretical aspects of analog states of isobaric spin are presented. An experimental method of determination of excitation functions is described. Results obtained for analog states in bismuth 207-208 are discussed. Results obtained on four steady lead isotopes in different laboratories are compared

  14. Licensing reform in the USA

    International Nuclear Information System (INIS)

    The licensing process for nuclear power plants in the USA is currently in two distinct stages: the issuance of a construction permit followed later by the issuance of an operation license. The ''two-step'' process has come under heavy criticism from the U.S. nuclear industry on the grounds that it causes uncertainty and delays and therefore inhibits new commitments to nuclear power plants. In 1989 the NRC published new regulations for the licensing of nuclear power plants which provide for the issuance of early site permits, safety certifications of standard designs, and combined construction permits and operating licences. The new rule was challenged by intervenors representing antinuclear groups who filed a legal challenge seeking to have the rule set aside on the grounds that it violates the Atomic Energy Act which they allege makes two-step licensing mandatory. In November 1990 the US Court of Appeals upheld the NRC's authority to issue combined licenses. An appeal for a rehearing has been filed. The paper analyses the events and the possible consequences of an adverse court decision. It reviews the options open to the NRC and industry if the court decision is upheld. The possibility of congressional action to amend the Atomic Energy Act is discussed. (author)

  15. Hydrothermal circulation at the world's highest lake? An environmental study of the Licancabur Volcano crater lake as a terrestrial analog to martian paleolakes.

    Science.gov (United States)

    Hock, A. N.; Cabrol, N. A.; Grin, E. A.; Fike, D. A.; Paige, D. A.; 2002 Licancabur Expedition Team

    2003-04-01

    At approximately 6000 meters above sea level, the crater of Licancabur Volcano (22 50'S, 67 53'W) houses the highest lake in the world, yet remains largely unexplored. In particular, the physical environment of the lake--particularly its stability and any remaining geothermal activity--is not well understood. Using a model for the temperature of maximum density for freshwater as a function of pressure (Eklund), we calculated that the bottom water temperature of the summit lake should be approximately 4 C. However, Leach et al. measured the water temperature at depth to be 6 C. This discrepancy, as well as the observation that the lake remains liquid for much of the year despite sub freezing air temperatures, suggests that there may be a heat source supporting the lake's temperature and biological community. We present the results of two studies here: the goal of this work is to understand the role of geothermal fluid input to the summit lake in terms of energy balance, the physical constraints on endemic biology, and the analogy to ancient martian hydrothermal systems (e.g. volcanic lakes, crater lakes, hot springs, etc.). First, we present physical data from the lake in a new model of energy balance. In situ measurements of pH, temperature, and total dissolved solids suggest that the Licancabur summit lake is a ¨low-activity¨ (as per Pasternack and Varekamp) lake with a diffuse geothermal fluid input. Secondly, mass spectrometry and ion chromatography were used to study water samples taken from the summit lake, as well as two local lagunas and several geothermal springs at the base of the volcano. The case for a hydrothermal system in the summit lake is further strengthened here by preliminary ion chromatography results, which show elevated concentrations of sulfate and chloride with respect to local meteoric waters. Understanding the relationship between the physical environment and biotic community remains the mainstay for future work on this project in an

  16. Biological Analogs for Language Contact Situations

    Science.gov (United States)

    Seliger, Herbert W.

    1977-01-01

    This article proposes that language contact can be best understood if the entire range of such situations from second language learning to evolution of dialects and creoles is studied within a framework analogical to the symbiosis of living organisms. Language contact is viewed in terms of dynamic evolutionary stages. (CHK)

  17. Radiation Behavior of Analog Neural Network Chip

    Science.gov (United States)

    Langenbacher, H.; Zee, F.; Daud, T.; Thakoor, A.

    1996-01-01

    A neural network experiment conducted for the Space Technology Research Vehicle (STRV-1) 1-b launched in June 1994. Identical sets of analog feed-forward neural network chips was used to study and compare the effects of space and ground radiation on the chips. Three failure mechanisms are noted.

  18. Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: Relevance of p53 and its clinical implications

    OpenAIRE

    Valdez, Benigno C.; Wang, Guiyun; Murray, David; Nieto, Yago; Li, Yang; Shah, Jatin; Turturro, Francesco; Wang, Michael; Weber, Donna M.; Champlin, Richard E.; Qazilbash, Muzaffar H; Andersson, Borje S.

    2013-01-01

    Hematopoietic stem cell transplantation (HSCT) is an established treatment for multiple myeloma (MM), a plasma cell malignancy. To identify an improved pretransplant conditioning regimen, we investigated the cytotoxicity of gemcitabine (Gem) and clofarabine (Clo) combinations toward MM cell lines and patient cell samples. A strong synergism of the two nucleoside analogs, when combined at their approximate IC10 concentrations, was observed. This synergism could be partly due to the observed Ge...

  19. NRC licensing of uranium enrichment plants

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission (NRC) is preparing a rule making that establishes the licensing requirements for low-enriched uranium enrichment plants. Although implementation of this rule making is timed to correspond with receipt of a license application for the Louisiana Energy Services centrifuge enrichment plant, the rule making is applicable to all uranium enrichment technologies. If ownership of the US gaseous diffusion plants and/or atomic vapor laser isotope separation is transferred to a private or government corporation, these plants also would be licensable under the new rule making. The Safeguards Studies Department was tasked by the NRC to provide technical assistance in support of the rule making and guidance preparation process. The initial and primary effort of this task involved the characterization of the potential safeguards concerns associated with a commercial enrichment plant, and the licensing issues associated with these concerns. The primary safeguards considerations were identified as detection of the loss of special nuclear material, detection of unauthorized production of material of low strategic significance, and detection of production of uranium enriched to >10% 235U. The primary safeguards concerns identified were (1) large absolute limit of error associated with the material balance closing, (2) the inability to shutdown some technologies to perform a cleanout inventory of the process system, and (3) the flexibility of some technologies to produce higher enrichments. Unauthorized production scenarios were identified for some technologies that could prevent conventional material control and accounting programs from detecting the production and removal of 5 kg 235U as highly enriched uranium. Safeguards techniques were identified to mitigate these concerns

  20. 76 FR 31616 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2011-06-01

    ... model. Radiology 2006 Apr;239(1);86-93. Licensing Status: Available for licensing. Licensing Contacts...@mail.nih.gov . Collaborative Research Opportunity: The NIH Clinical Center, Interventional...

  1. Licensing process characteristics of Small Modular Reactors and spent nuclear fuel repository

    Energy Technology Data Exchange (ETDEWEB)

    Söderholm, Kristiina, E-mail: kristiina.soderholm@fortum.com [Fortum Power (Finland); Tuunanen, Jari, E-mail: jari.tuunanen@fortum.com [Fortum Power (Finland); Amaba, Ben, E-mail: baamaba@us.ibm.com [IBM Complex Systems (United States); Bergqvist, Sofia, E-mail: sofia.bergqvist@se.ibm.com [IBM Rational Software (Sweden); Lusardi, Paul, E-mail: plusardi@nuscalepower.com [NuScale Power (United States)

    2014-09-15

    Highlights: • We examine the licensing process challenges of modular nuclear facilities. • We compare the features of Small Modular Reactors and spent nuclear fuel repository. • We present the need of nuclear licensing simplification. • Part of the licensing is proposed to be internationally applicable. • Systems engineering and requirements engineering benefits are presented. - Abstract: This paper aims to increase the understanding of the licensing processes characteristics of Small Modular Reactors (SMR) compared with licensing of spent nuclear fuel repository. The basis of the SMR licensing process development lies in licensing processes used in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their various licensing processes and recent actions in the new NPP construction. Certain aspects of the aviation industry licensing process have also been studied and selected practices have been investigated as possibly suitable for use in nuclear licensing. Suitable features for SMR licensing are emphasized and suggested. The licensing features of the spent nuclear fuel deep repository along with similar features of SMR licensing are discussed. Since there are similar types of challenges of lengthy licensing time frames, as well as modular features to be taken into account in licensing, these two different nuclear industry fields can be compared. The main SMR features to take into account in licensing are: • Standardization of the design. • Modularity. • Mass production. • Serial construction. Modularity can be divided into two different categories: the first category is simply a single power plant unit constructed of independently engineered modules (e.g. construction process for Westinghouse AP-1000 NPP) and the second one a power plant composed of many reactor modules, which are manufactured in factories and installed as needed (e.g. NuScale Power SMR design). The deep underground repository

  2. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel J M

    2010-01-01

    The design of an analog-to-digital converter or digital-to-analog converter is one of the most fascinating tasks in micro-electronics. In a converter the analog world with all its intricacies meets the realm of the formal digital abstraction. Both disciplines must be understood for an optimum conversion solution. In a converter also system challenges meet technology opportunities. Modern systems rely on analog-to-digital converters as an essential part of the complex chain to access the physical world. And processors need the ultimate performance of digital-to-analog converters to present the results of their complex algorithms. The same progress in CMOS technology that enables these VLSI digital systems creates new challenges for analog-to-digital converters: lower signal swings, less power and variability issues. Last but not least, the analog-to-digital converter must follow the cost reduction trend. These changing boundary conditions require micro-electronics engineers to consider their design choices for...

  3. Nuclear power plant operator licensing

    International Nuclear Information System (INIS)

    The guide applies to the nuclear power plant operator licensing procedure referred to the section 128 of the Finnish Nuclear Energy Degree. The licensing procedure applies to shift supervisors and those operators of the shift teams of nuclear power plant units who manipulate the controls of nuclear power plants systems in the main control room. The qualification requirements presented in the guide also apply to nuclear safety engineers who work in the main control room and provide support to the shift supervisors, operation engineers who are the immediate superiors of shift supervisors, heads of the operational planning units and simulator instructors. The operator licensing procedure for other nuclear facilities are decided case by case. The requirements for the basic education, work experience and the initial, refresher and complementary training of nuclear power plant operating personnel are presented in the YVL guide 1.7. (2 refs.)

  4. NRC licensing requirements: DOD options

    Energy Technology Data Exchange (ETDEWEB)

    Pike, W.J.; O' Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with /sup 90/Sr or /sup 238/Pu; radioisotopic dynamic electric generators with /sup 90/Sr or /sup 238/Pu; and applications of radioisotopes for luminous sources (lights) with /sup 3/H, /sup 85/Kr, or /sup 147/Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process.

  5. NRC licensing requirements: DOD options

    International Nuclear Information System (INIS)

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with 90Sr or 238Pu; radioisotopic dynamic electric generators with 90Sr or 238Pu; and applications of radioisotopes for luminous sources (lights) with 3H, 85Kr, or 147Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process

  6. Osilodrostat (LCI699), a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats

    Energy Technology Data Exchange (ETDEWEB)

    Li, Li, E-mail: li1.li@novartis.com [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Vashisht, Kapil; Boisclair, Julie [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Li, Wenkui; Lin, Tsu-han [Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Schmid, Herbert A. [Novartis Oncology Development, Basel (Switzerland); Kluwe, William; Schoenfeld, Heidi; Hoffmann, Peter [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States)

    2015-08-01

    The somatostatin analog pasireotide and the 11β-hydroxylase inhibitor osilodrostat (LCI699) reduce cortisol levels by distinct mechanisms of action. There exists a scientific rationale to investigate the clinical efficacy of these two agents in combination. This manuscript reports the results of a toxicology study in rats, evaluating different doses of osilodrostat and pasireotide alone and in combination. Sixty male and 60 female rats were randomized into single-sex groups to receive daily doses of pasireotide (0.3 mg/kg/day, subcutaneously), osilodrostat (20 mg/kg/day, orally), osilodrostat/pasireotide in combination (low dose, 1.5/0.03 mg/kg/day; mid-dose, 5/0.1 mg/kg/day; or high dose, 20/0.3 mg/kg/day), or vehicle for 13 weeks. Mean body-weight gains from baseline to Week 13 were significantly lower in the pasireotide-alone and combined-treatment groups compared to controls, and were significantly higher in female rats receiving osilodrostat monotherapy. Osilodrostat and pasireotide monotherapies were associated with significant changes in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat alone was associated with adrenocortical hypertrophy and hepatocellular hypertrophy. In combination, osilodrostat/pasireotide did not exacerbate any target organ changes and ameliorated the liver and adrenal gland changes observed with monotherapy. C{sub max} and AUC{sub 0–24h} of osilodrostat and pasireotide increased in an approximately dose-proportional manner. In conclusion, the pasireotide and osilodrostat combination did not exacerbate changes in target organ weight or toxicity compared with either monotherapy, and had an acceptable safety profile; addition of pasireotide to the osilodrostat regimen may attenuate potential adrenal gland hyperactivation and hepatocellular hypertrophy, which are potential side effects of osilodrostat monotherapy. - Highlights: • We examined the target organ toxicity of SOM230

  7. Osilodrostat (LCI699), a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats

    International Nuclear Information System (INIS)

    The somatostatin analog pasireotide and the 11β-hydroxylase inhibitor osilodrostat (LCI699) reduce cortisol levels by distinct mechanisms of action. There exists a scientific rationale to investigate the clinical efficacy of these two agents in combination. This manuscript reports the results of a toxicology study in rats, evaluating different doses of osilodrostat and pasireotide alone and in combination. Sixty male and 60 female rats were randomized into single-sex groups to receive daily doses of pasireotide (0.3 mg/kg/day, subcutaneously), osilodrostat (20 mg/kg/day, orally), osilodrostat/pasireotide in combination (low dose, 1.5/0.03 mg/kg/day; mid-dose, 5/0.1 mg/kg/day; or high dose, 20/0.3 mg/kg/day), or vehicle for 13 weeks. Mean body-weight gains from baseline to Week 13 were significantly lower in the pasireotide-alone and combined-treatment groups compared to controls, and were significantly higher in female rats receiving osilodrostat monotherapy. Osilodrostat and pasireotide monotherapies were associated with significant changes in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat alone was associated with adrenocortical hypertrophy and hepatocellular hypertrophy. In combination, osilodrostat/pasireotide did not exacerbate any target organ changes and ameliorated the liver and adrenal gland changes observed with monotherapy. Cmax and AUC0–24h of osilodrostat and pasireotide increased in an approximately dose-proportional manner. In conclusion, the pasireotide and osilodrostat combination did not exacerbate changes in target organ weight or toxicity compared with either monotherapy, and had an acceptable safety profile; addition of pasireotide to the osilodrostat regimen may attenuate potential adrenal gland hyperactivation and hepatocellular hypertrophy, which are potential side effects of osilodrostat monotherapy. - Highlights: • We examined the target organ toxicity of SOM230 (pasireotide

  8. Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats

    OpenAIRE

    Jun-Xian, YU; Voruganti, Sukesh; Dan-Dan, LI; Qin, Jiang-Jiang; Nag, Subhasree; Xu, Su; Velu, Sadanandan E.; Wang, Wei; Zhang, Ruiwen

    2015-01-01

    We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers. Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog, TCBA-TPQ, and conducted a pharmacokinetic study in laboratory rats. Our results indicated that the HPLC-MS/MS method was precise, accurate, and specific. Using this method, we carried out in vitro...

  9. Applying analog integrated circuits for HERO protection

    Science.gov (United States)

    Willis, Kenneth E.; Blachowski, Thomas J.

    1994-01-01

    One of the most efficient methods for protecting electro-explosive devices (EED's) from HERO and ESD is to shield the EED in a conducting shell (Faraday cage). Electrical energy is transferred to the bridge by means of a magnetic coupling which passes through a portion of the conducting shell that is made from a magnetically permeable but electrically conducting material. This technique was perfected by ML Aviation, a U.K. company, in the early 80's, and was called a Radio Frequency Attenuation Connector (RFAC). It is now in wide use in the U.K. Previously, the disadvantage of RFAC over more conventional methods was its relatively high cost, largely driven by a thick film hybrid circuit used to switch the primary of the transformer. Recently, through a licensing agreement, this technology has been transferred to the U.S. and significant cost reductions and performance improvements have been achieved by the introduction of analog integrated circuits. An integrated circuit performs the following functions: (1) Chops the DC input to a signal suitable for driving the primary of the transformer; (2) Verifies the input voltage is above a threshold; (3) Verifies the input voltage is valid for a pre set time before enabling the device; (4) Provides thermal protection of the circuit; and (5) Provides an external input for independent logic level enabling of the power transfer mechanism. This paper describes the new RFAC product and its applications.

  10. Analog Systems for Gravity Duals

    OpenAIRE

    Hossenfelder, S.

    2014-01-01

    We show that analog gravity systems exist for charged, planar black holes in asymptotic Anti-de Sitter space. These black holes have been employed to describe, via the gauge-gravity duality, strongly coupled condensed matter systems on the boundary of AdS-space. The analog gravity system is a different condensed matter system that, in a suitable limit, describes the same bulk physics as the theory on the AdS boundary. This combination of the gauge-gravity duality and analog gravity therefore ...

  11. Technology Licensing and Firm Innovation

    DEFF Research Database (Denmark)

    Moreira, Solon

    Although licensing has repeatedly been acknowledged to be a major vehicle for firms to acquire external knowledge, surprisingly little is known about how firms use it as part of their overall inventive efforts. Furthermore, with the exception of absorptive capacity, the organizational determinants...... relationship. The findings also suggest that high levels of Organizational Slack (available financial resources) strengthen the positive effect of licensing on innovation. However, higher levels of Organizational Myopia (the extent to which a firm draws on its own knowledge) can decrease the main effect of...

  12. A Developers Bill of Rights: What Open Source Developers Want in a Software License

    OpenAIRE

    MacCormack, Alan

    2007-01-01

    In this paper, we study open source developers' perspectives on the nature and structure of software licenses as well as the processes through which these licenses are designed. Recent history has shown that software licensing approaches are critical to the dynamics of the software industry and the open source ecosystem, and thus of interest to the many policy makers and practitioners that follow this part of the global economy. The study is timely, since it informs the debate on the revision...

  13. Use of analogies by novice and experienced design engineers

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Christensen, Bo T.

    2008-01-01

    This paper describes a study to understand the use of analogies by design engineers with different levels of experience. Protocol analyses of twelve design engineers have been analysed to understand the functions and reasoning of the analogies. The protocols are real world data from the aerospace...

  14. Analysis of Attention and Analogical Reasoning in Children of Poverty

    Science.gov (United States)

    Weatherholt, Tara N.; Harris, Ruby C.; Burns, Barbara M.; Clement, Catherine

    2006-01-01

    This study examined the relationship between specific attentional aspects of processing capacity and analogical reasoning in children from low-income families. 77 children aged 48-77 (M = 56.7) months were assessed on an analogical reasoning task (matrices subtest of the Kaufman Brief Intelligence Test) and on computerized attention tasks designed…

  15. Young Children's Analogical Problem Solving: Gaining Insights from Video Displays

    Science.gov (United States)

    Chen, Zhe; Siegler, Robert S.

    2013-01-01

    This study examined how toddlers gain insights from source video displays and use the insights to solve analogous problems. Two- to 2.5-year-olds viewed a source video illustrating a problem-solving strategy and then attempted to solve analogous problems. Older but not younger toddlers extracted the problem-solving strategy depicted in the video…

  16. Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats.

    Science.gov (United States)

    Yu, Jun-Xian; Voruganti, Sukesh; Li, Dan-Dan; Qin, Jiang-Jiang; Nag, Subhasree; Xu, Su; Velu, Sadanandan E; Wang, Wei; Zhang, Ruiwen

    2015-07-01

    We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers. Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog, TCBA-TPQ, and conducted a pharmacokinetic study in laboratory rats. Our results indicated that the HPLC-MS/MS method was precise, accurate, and specific. Using this method, we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats. Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog. PMID:26233847

  17. Analog filters in nanometer CMOS

    CERN Document Server

    Uhrmann, Heimo; Zimmermann, Horst

    2014-01-01

    Starting from the basics of analog filters and the poor transistor characteristics in nanometer CMOS 10 high-performance analog filters developed by the authors in 120 nm and 65 nm CMOS are described extensively. Among them are gm-C filters, current-mode filters, and active filters for system-on-chip realization for Bluetooth, WCDMA, UWB, DVB-H, and LTE applications. For the active filters several operational amplifier designs are described. The book, furthermore, contains a review of the newest state of research on low-voltage low-power analog filters. To cover the topic of the book comprehensively, linearization issues and measurement methods for the characterization of advanced analog filters are introduced in addition. Numerous elaborate illustrations promote an easy comprehension. This book will be of value to engineers and researchers in industry as well as scientists and Ph.D students at universities. The book is also recommendable to graduate students specializing on nanoelectronics, microelectronics ...

  18. Managing Licensing in a Market for Technology

    DEFF Research Database (Denmark)

    Arora, Ashish; Fosfuri, Andrea; Rønde, Thomas

    2013-01-01

    valuable licensing opportunities because the rewards for licensing are (optimally) weaker than those for product market profits. This distortion is stronger when production-based incentives, especially private benefits, of business unit managers are more powerful, making centralization more attractive......Technology licensing is an important means for companies to extract more value from their intellectual assets. We build a model that helps understand how licensing activity should be organized within large corporations. More specifically, we compare decentralization—where the business unit using...... the technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend on product market performance. If licensing is decentralized, the business unit forgoes...

  19. Guide to request license for teletherapy practice

    International Nuclear Information System (INIS)

    In this work the steps to request license for teletherapy practice are described , among these steps they it continued it plows to request the qualified personnel's yams, the operation authorization, application purpose, license type

  20. List of Nuclear Materials Licensing Actions Received

    Data.gov (United States)

    Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

  1. Scallop License Limitation Program (SLLP) Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A federal Scallop License Limitation Program (SLLP) license is required onboard any vessel deployed in scallop fisheries in Federal waters off Alaska (except for...

  2. Towards power centric analog design

    OpenAIRE

    Svensson, Christer

    2015-01-01

    Power consumption of analog systems is poorly understoodtoday, in contrast to the very well developed analysis of digitalpower consumption. We show that there is good opportunity todevelop also the analog power understanding to a similar levelas the digital. Such an understanding will have a large impact inthe design of future electronic systems, where low power consumptionwill be crucial. Eventually we may reach a power centricanalog design methodology.

  3. Legal Challenges to Licensing Examinations.

    Science.gov (United States)

    Pyburn, Keith M., Jr.

    1990-01-01

    Discrepancies between court and professional association views of licensing examinations are discussed. Litigation associated with Title VII of the Civil Rights Act of 1964 and constitutional law is considered. Courts should examine professional standards and apply those that are consistent with the court's determination of the proper…

  4. In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations

    OpenAIRE

    Xiaodong Gao; Liping Han; Yujie Ren

    2016-01-01

    Checkpoint kinase 1 (Chk1) is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative structure–activity relationship (3D-QSAR) modeling, molecular docking, and molecular dynamics simulatio...

  5. 25 CFR 11.601 - Marriage licenses.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Marriage licenses. 11.601 Section 11.601 Indians BUREAU... ORDER CODE Domestic Relations § 11.601 Marriage licenses. A marriage license shall be issued by the clerk of the court in the absence of any showing that the proposed marriage would be invalid under...

  6. Operation of Trades Licensing Office after the amendment of Trades Licensing Act

    OpenAIRE

    Neužilová, Barbora

    2011-01-01

    My work "Operation of Trades Licensing Office after amendement of the Trades Licensing Act" deals with valid legal regulation of the Trade Licensing Act, which the officers follow. My work is divided into two parts. The first part contains the valid legal regulation. Here I analyse not only the Trades Licensing Act, but also the law about Trades Licensing Offices. Further, the practical part follows. At the beginnning of the practical part of my work I describe the operations of the rele...

  7. Molecular interactions between (--epigallocatechin gallate analogs and pancreatic lipase.

    Directory of Open Access Journals (Sweden)

    Shihui Wang

    Full Text Available The molecular interactions between pancreatic lipase (PL and four tea polyphenols (EGCG analogs, like (--epigallocatechin gallate (EGCG, (--gallocatechin gallate (GCG, (--epicatechin gallate (ECG, and (--epigallocatechin (EC, were studied from PL activity, conformation, kinetics and thermodynamics. It was observed that EGCG analogs inhibited PL activity, and their inhibitory rates decreased by the order of EGCG>GCG>ECG>EC. PL activity at first decreased rapidly and then slowly with the increase of EGCG analogs concentrations. α-Helix content of PL secondary structure decreased dependent on EGCG analogs concentration by the order of EGCG>GCG>ECG>EC. EGCG, ECG, and EC could quench PL fluorescence both dynamically and statically, while GCG only quenched statically. EGCG analogs would induce PL self-assembly into complexes and the hydrodynamic radii of the complexes possessed a close relationship with the inhibitory rates. Kinetics analysis showed that EGCG analogs non-competitively inhibited PL activity and did not bind to PL catalytic site. DSC measurement revealed that EGCG analogs decreased the transition midpoint temperature of PL enzyme, suggesting that these compounds reduced PL enzyme thermostability. In vitro renaturation through urea solution indicated that interactions between PL and EGCG analogs were weak and non-covalent.

  8. A Pilot Study of the Effect of a Change in the Scheduling of Canadian Medical Licensing Examinations on Two Cohorts of Students Studying in Ireland

    Directory of Open Access Journals (Sweden)

    Kate Niethammer

    2015-03-01

    Full Text Available Background: The Medical Council of Canada and most Canadian residency programs require international medical graduates seeking training in Ca­nada to pass the Medical Council of Canada Entrance Examination, in addition to the newly established National Collaborative Assessment. In order to facilitate this additional examination, the Medical Council of Canada has altered the suggested examination timeline and examination eligibility criteria. Methods: A cross-sectional survey was sent via an online survey tool to members of the North American Irish Medical Student Association. The survey aimed to elicit differences in the Medical Council of Canada Entrance Examination experience between two cohorts of Canadians studying abroad in Ireland: those who completed the examination before and after the new timeline. Statistical analysis was conducted with independent t-tests and Pearson’s Chi-Square tests using SPSS version 21. Results: Of 24 respondents, 13 had completed the examination after the timeline change. Participants who attended the examination prior to the change achieved higher results (353.8 ± 56.5 than participants who attended the examination after the change (342.3 ± 35.1, although not statistically significant (p=0.56. In the cohort who took the examination after the timeline change, 61.5% of participants expressed discontent with their examination results; 84.6% ‘strongly agreed’ or ‘agreed’ to feeling disadvantaged due to the change. Conclusion: The new Medical Council of Canada examination timeline has had an impact on the examination experience of Canadians studying in Ireland. Simple modifications to the current timeline are warranted to reduce unnecessary disadvantage for this cohort of students applying to postgraduate training in Canada.

  9. Licensing process for the power increase

    International Nuclear Information System (INIS)

    The licensing process for the power increase of a nuclear power station is presented, this includes the description of the effective normative framework, the attributions of the one Mexican regulator organism in nuclear matter, the definition and importance of the power level of a nuclear reactor for the safety studies. Also, the types of power increase according to its magnitude, and the regulator process that it includes the scope and the detail of the required information that it should be evaluated by the one regulator organism are discussed. Finally it offers a summary of the experience that one has in Mexico for this type of processes. (Author)

  10. Wavelet packet based feature extraction and recognition of license plate characters

    Institute of Scientific and Technical Information of China (English)

    HUANG Wei; LU Xiaobo; LING Xiaojing

    2005-01-01

    To study the characteristics of license plate characters recognition, this paper proposes a method for feature extraction of license plate characters based on two-dimensional wavelet packet. We decompose license plate character images with two dimensional-wavelet packet and search for the optimal wavelet packet basis. This paper presents a criterion of searching for the optimal wavelet packet basis, and a practical algorithm. The obtained optimal wavelet packet basis is used as the feature of license plate character, and a BP neural network is used to classify the character.The testing results show that the proposed method achieved higher recognition rate than the traditional methods.

  11. Crows spontaneously exhibit analogical reasoning.

    Science.gov (United States)

    Smirnova, Anna; Zorina, Zoya; Obozova, Tanya; Wasserman, Edward

    2015-01-19

    Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually. In RMTS, choice of test pair BB would be correct if the sample pair were AA, whereas choice of test pair EF would be correct if the sample pair were CD. Critically, no items in the correct test pair physically match items in the sample pair, thus demanding that only relational sameness or differentness is available to support accurate choice responding. Initial evidence suggested that only humans and apes can successfully learn RMTS with pairs of sample and test items; however, monkeys have subsequently done so. Here, we report that crows too exhibit relational matching behavior. Even more importantly, crows spontaneously display relational responding without ever having been trained on RMTS; they had only been trained on identity matching-to-sample (IMTS). Such robust and uninstructed relational matching behavior represents the most convincing evidence yet of analogical reasoning in a nonprimate species, as apes alone have spontaneously exhibited RMTS behavior after only IMTS training. PMID:25532894

  12. A single center, open, randomized study investigating the clinical safety and the endothelial modulating effects of a prostacyclin analog in combination with eptifibatide in patients having undergone primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction

    DEFF Research Database (Denmark)

    Holmvang, Lene; Ostrowski, Sisse Rye; Dridi, Nadia Paarup;

    2012-01-01

    Treatment with the endothelial modulator prostacyclin may be beneficial in patients with endothelial dysfunction. The primary aim of the present pilot study was to evaluate the safety and the potential endothelial modulating affect of the prostacyclin analog iloprost in patients with a recent ST...... segment elevation myocardial infarction (STEMI). Seventeen patients were randomized to either 24h of iloprost infusion in combination with low dose eptifibatide infusion or saline infusion+eptifibatide. The study was randomized and open labeled. None of the patients experienced any bleeding complications...... activated endothelium in patients with a recent STEMI. ClinicalTrials.gov: NCT01179776....

  13. Managing Licensing in a Market for Technology

    DEFF Research Database (Denmark)

    Arora, Ashish; Rønde, Thomas; Fosfuri, Andrea

    Over the last decade, companies have paid greater attention to the management of their intellectual assets. We build a model that helps understand how licensing activity should be organized within large corporations. More specifically, we compare decentralization—where the business unit using the...... technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend upon product market performance. If licensing is decentralized, the business unit forgoes valuable...... licensing opportunities since the rewards for licensing are (optimally) weaker than those for product market profits. This distortion is stronger when production-based incentives are more powerful, making centralization more attractive. Growth of technology markets favors centralization and drives higher...

  14. Licensing plan for UMTRA project disposal sites

    International Nuclear Information System (INIS)

    The Uranium Mill Tailings Remedial Action (UMTRA) Project Office developed a plan to define UMTRA Project licensing program objectives and establish a process enabling the DOE to document completion of remedial actions in compliance with 40 CFR 1 92 and the requirements of the NRC general license. This document supersedes the January 1987 Project Licensing Plan (DOE, 1987). The plan summarizes the legislative and regulatory basis for licensing, identifies participating agencies and their roles and responsibilities, defines key activities and milestones in the licensing process, and details the coordination of these activities. This plan provides an overview of the UMTRA Project from the end of remedial actions through the NRC's acceptance of a disposal site under the general license. The licensing process integrates large phases of the UMTRA Project. Other programmatic UMTRA Project documents listed in Section 6.0 provide supporting information

  15. Analog electronics for radiation detection

    CERN Document Server

    2016-01-01

    Analog Electronics for Radiation Detection showcases the latest advances in readout electronics for particle, or radiation, detectors. Featuring chapters written by international experts in their respective fields, this authoritative text: Defines the main design parameters of front-end circuitry developed in microelectronics technologies Explains the basis for the use of complementary metal oxide semiconductor (CMOS) image sensors for the detection of charged particles and other non-consumer applications Delivers an in-depth review of analog-to-digital converters (ADCs), evaluating the pros and cons of ADCs integrated at the pixel, column, and per-chip levels Describes incremental sigma delta ADCs, time-to-digital converter (TDC) architectures, and digital pulse-processing techniques complementary to analog processing Examines the fundamental parameters and front-end types associated with silicon photomultipliers used for single visible-light photon detection Discusses pixel sensors ...

  16. Streamlining the license renewal review process

    International Nuclear Information System (INIS)

    The staff of the NRC has been developing three regulatory guidance documents for license renewal: the Generic Aging Lessons Learned (GALL) report, Standard Review Plan for License Renewal (SRP-LR), and Regulatory Guide (RG) for Standard Format and Content for Applications to Renew Nuclear Power Plant Operating Licenses. These documents are designed to streamline the license renewal review process by providing clear guidance for license renewal applicants and the NRC staff in preparing and reviewing license renewal applications. The GALL report systematically catalogs aging effects on structures and components; identifies the relevant existing plant programs; and evaluates the existing programs against the attributes considered necessary for an aging management program to be acceptable for license renewal. The GALL report also provides guidance for the augmentation of existing plant programs for license renewal. The revised SRP-LR allows an applicant to reference the GALL report to preclude further NRC staff evaluation if the plant's existing programs meet the criteria described in the GALL report. During the review process, the NRC staff will focus primarily on existing programs that should be augmented or new programs developed specifically for license renewal. The Regulatory Guide is expected to endorse the Nuclear Energy Institute (NEI) guideline, NEI 95-10, Revision 2, entitled 'Industry Guideline for Implementing the Requirements of 10 CFR Part 54 - The License Renewal Rule', which provides guidance for preparing a license renewal application. This paper will provide an introduction to the GALL report, SRP-LR, Regulatory Guide, and NEI 95-10 to show how these documents are interrelated and how they will be used to streamline the license renewal review process. This topic will be of interest to domestic power utilities considering license renewal and international ICONE participants seeking state-of-the-art information about license renewal in the United States

  17. Asserting the primacy of health over patent rights: a comparative study of the processes that led to the use of compulsory licensing in Thailand and Brazil.

    Science.gov (United States)

    Rosenberg, Stephanie T

    2014-08-01

    Since the 1970s, the United States has adopted a trade policy agenda that has forced countries to trade away flexible patent provisions for access to US markets. While pharmaceutical companies have argued that the recognition of patent rights is essential for recovering investments in research and development of pharmaceuticals and incentivizing future innovation, the lack of competition has had damaging consequences for public health, as companies tend to set the prices of treatments beyond the reach of consumers and government programs. Thailand and Brazil are bound by law to provide universal access to anti-retroviral treatment (ART) to People Living with HIV/AIDS (PLWHA). This has been made possible in part due to the universal health care systems in each country and the countries' local technical and industrial capacities that provide the government with affordable generic medicines. The introduction of stronger intellectual property protection laws however, has limited possibilities for procuring generic medicines and inflated the cost of treatment. Between 2006-2008, Thailand and Brazil used compulsory licensing to authorize generic competition against the consent of the pharmaceutical companies in order to guarantee the right to health and ensure the viability of government health budgets. This paper will demonstrate how the interaction between individual / collective action and structural and institutional elements in Thailand and Brazil produced propitious conditions for each country to assert the primacy of health over patent rights. PMID:24750542

  18. The post-closure radiological safety case for a spent fuel repository in Sweden - An international peer review of the SKB license-application study of March 2011

    International Nuclear Information System (INIS)

    Sweden is at the forefront among countries developing plans for a deep geological repository of highly radioactive waste. There is no such repository in operation yet worldwide, but Sweden, Finland and France are approaching the licensing stage. At the request of the Swedish government, the NEA organised an international peer review of the post-closure radiological safety case produced by the Swedish Nuclear Fuel and Waste Management Company (SKB) in support of the application for a general licence to construct and operate a spent nuclear fuel geological repository in the municipality of Oesthammar. The purpose of the review was to help the Swedish government, the public and relevant organisations by providing an international reference regarding the maturity of SKB's spent fuel disposal programme vis-a-vis best practices in long-term disposal safety and radiological protection. The International Review Team (IRT) consisted of ten international specialists, who were free of conflict of interest with the SKB and brought complementary expertise to the review. This report provides the background and findings of the international peer review. The review's findings are presented at several levels of detail in order to be accessible to both specialist and non-specialist readers

  19. A safety licensable computing architecture

    CERN Document Server

    Halang, WA; Jung, S-K; Scheepstra, JJ

    1993-01-01

    This book describes the design of a low complexity, fault-detecting computer architecture for utilisation in programmable logic controllers (PLCs) for process control purposes. The cyclic operating mode of PLCs and a specification level graphical programming paradigm based on interconnecting application-oriented standard software function modules are architecturally supported. Thus, by design, there is no semantic gap between the specification, programming and machine execution levels enabling the safety licensing of application software by diverse back translation, an extremely simple but rig

  20. Comparing Analog and Digital Hearing Aids in Reducing Hearing Disability

    OpenAIRE

    Ghassem Mohammad Khani; Mohammad Hassan Khalesi; Soghrat Faghih Zadeh; Bahieh Kohansal; Zahra Jafari

    2004-01-01

    Objective: Comparing analog and digital hearing aids reducing disability caused by hearing deficiency among moderate to severe sensorineural hearing-impaired persons. Method and Material: This descriptive-analytic study was carried out on two groups of subjects participated in this study in some audiology clinics of hearing aid since May 2002 to October 2003. Twenty subjects wore analog hearing aids and twenty one subjects wore digital hearing aids. In this study , no subject had previous mid...

  1. Application handbook for analog IC

    International Nuclear Information System (INIS)

    This book consists of ten chapters, which are prolog on analog IC and digital, basic function of OP amp for operation, characteristic on direct current and interchange, Op amp and linear circuit, nonlinear arithmetic circuit, filter circuit, oscillation circuit and V-F converter, D-A converter, A-D converter on introduction eight bit and 12 bit, I C for power supply and switching regulator. Each chapter has the explanations of specific function of the programs, filter circuit, converters. So, this book is a application handbook for analog IC.

  2. NASA HRP Immunology Discipline - Use of Terrestrial Analogs

    Science.gov (United States)

    Crucian, Brian

    2014-01-01

    Due to the cost and operational constraints, as well as technical implementation limitations, it is desirous to perform relevant space physiology investigations first in terrestrial 'space analogs'. This is particularly true for initial investigations, which may then provide appropriate focus for subsequent flight investigations, or for mechanistic investigations that simply cannot be performed during spaceflight. Appropriate analog choice is extremely important. There are a wide variety of terrestrial space analogs, each relevant to a particular physiological discipline (or disciplines) and each with a particular fidelity (or lack thereof) to spaceflight, and each with unique operational constraints. The HRP Immunology Discipline is tasked with managing the HRP Risk concerning clinical risk for Astronaut crews related to spaceflight-associated immune dysregulation. Such dysregulation has been documented to occur during spaceflight, and found to persist for the duration of a 6-month ISS mission. Studies continue to characterize the onorbit phenomenon, but it generally consists of diminished immunocyte function, dysregulated cytokine profiles, and persistent herpesvirus reactivation. Causes are thought to synergistically include microgravity, psychological or physiological stress, radiation, and/or circadian misalignment. An appropriate terrestrial analog for immune dysregulation would replicate as many of these influences as possible. Such analogs may include clinostat or bioreactor cell culture (microgravity), hindlimb suspension (stress, fluid shifts, hypokinesis), or human deployment to remote or extreme environments (isolation, stress, circadian). Also, the laboratory setting may be used as an analog, or to augment analogs, such as sleep deprivation/misalignment or human centrifugation to replicate gravitational stress. As an appropriate example of a NASA Disciplines use of Terrestrial space analogs, this talk will discuss spaceflight associated immune

  3. Heat Transfer Analogies

    International Nuclear Information System (INIS)

    This report contains descriptions of various analogues utilised to study different steady-state and unsteady-state heat transfer problems. The analogues covered are as follows: 1 . Hydraulic: a) water flow b) air flow 2. Membrane 3. Geometric Electrical: a) Electrolytic-tank b) Conducting sheet 4. Network; a) Resistance b) R-C A comparison of the different analogues is presented in the form of a table

  4. High resolution tomography using analog coding

    International Nuclear Information System (INIS)

    As part of a 30-year program in the development of positron instrumentation, the authors have developed a high resolution bismuth germanate (BGO) ring tomography (PCR) employing 360 detectors and 90 photomultiplier tubes for one plane. The detectors are shaped as trapezoid and are 4 mm wide at the front end. When assembled, they form an essentially continuous cylindrical detector. Light from a scintillation in the detector is viewed through a cylindrical light pipe by the photomultiplier tubes. By use of an analog coding scheme, the detector emitting light is identified from the phototube signals. In effect, each phototube can identify four crystals. PCR is designed as a static device and does not use interpolative motion. This results in considerable advantage when performing dynamic studies. PCR is the positron tomography analog of the γ-camera widely used in nuclear medicine

  5. Licensing systems and inspection of nuclear installations in NEA Member countries. Part 1, Description of licensing systems

    International Nuclear Information System (INIS)

    This study provides an assessment of the legislative and regulatory provisions applicable and of the practices followed in the countries concerned and is divided into two separate sections. This document is the first part only. It contains the description of national licensing and inspection systems for nuclear installations in the twenty OECD countries which have specific regulations in this field. Each analysis has been presented following a plan which is as standardised as possible so as to facilitate comparison between the national systems. Part II, which is not included in this document, contains the diagrams illustrating the steps in the licensing procedure and the duties of the bodies involved as well as certain additional documents. It also includes a table showing the sequence of the main steps in the licensing process in the countries covered by this Study

  6. International Alligator Rivers Analog Project

    International Nuclear Information System (INIS)

    The Australian Nuclear Science and Technology Organization (ANSTO), the Japan Atomic Energy Research Institute, the Swedish Nuclear Power Inspectorate, the U.K. Department of the Environment, the US Nuclear Regulatory Commission (NRC), and the Power Reactor and Nuclear Fuel Development Corporation of Japan are participating under the aegis of the Nuclear Energy Agency in the International Alligator Rivers Analog Project. The project has a duration of 3 yr, starting in 1988. The project has grown out of a research program on uranium ore bodies as analogs of high-level waste (HLW) repositories undertaken by ANSTO supported by the NRC. A primary objective of the project is to develop an approach to radionuclide transport model validation that may be used by the participants to support assessments of the safety of radioactive waste repositories. The approach involves integrating mathematical and physical modeling with hydrological and geochemical field and laboratory investigations of the analog site. The Koongarra uranium ore body has been chosen as the analog site because it has a secondary ore body that has formed over the past million years as a result of leaching by groundwater flowing through fractures in the primary ore body

  7. Multichannel analog temperature sensing system

    International Nuclear Information System (INIS)

    A multichannel system that protects the numerous and costly water-cooled magnet coils on the translation section of the FRX-C/T magnetic fusion experiment is described. The system comprises a thermistor for each coil, a constant current circuit for each thermistor, and a multichannel analog-to-digital converter interfaced to the computer

  8. Analog Input Data Acquisition Software

    Science.gov (United States)

    Arens, Ellen

    2009-01-01

    DAQ Master Software allows users to easily set up a system to monitor up to five analog input channels and save the data after acquisition. This program was written in LabVIEW 8.0, and requires the LabVIEW runtime engine 8.0 to run the executable.

  9. Multichannel analog temperature sensing system

    Science.gov (United States)

    Gribble, R.

    1985-08-01

    A multichannel system that protects the numerous and costly water-cooled magnet coils on the translation section of the FRX-C/T magnetic fusion experiment is described. The system comprises a thermistor for each coil, a constant current circuit for each thermistor, and a multichannel analog-to-digital converter interfaced to the computer.

  10. A case history of successful nuclear power plant licensing

    International Nuclear Information System (INIS)

    Statewide siting studies, site-selection, site characterization and receipt of a construction permit for the Palo Verde Project were accomplished in 50 months. This achievement was made possible by (1) providing experienced project management leadership by the licensee, (2) retaining an attorney experienced with Nuclear Regulatory Commission (NRC) licensing, (3) developing a strategy for decision-making and licensing that was responsive to the needs of the NRC, (4) selecting a qualified investigative team of contractors and subcontractors, and (5) installing an architect/engineer to manage the contractors and provide independent review. A similar approach, applied to a high-level radioactive-waste repository program, should contribute to comparable licensing success

  11. License-Exempt Child Care Providers: A Needs Assessment for Designing an Implementation Model

    Science.gov (United States)

    Roseburr, Linda Joyce

    2008-01-01

    Many children from low-income families appear to be not receiving quality child care from their license-exempt subsidized child-care providers. The purpose of this qualitative case study was to obtain data from a sample of license-exempt providers/caregivers and parents from a mailed self-administered survey and telephone interview. Four research…

  12. Four Facets of Privacy and Intellectual Freedom in Licensing Contracts for Electronic Journals

    Science.gov (United States)

    Rubel, Alan; Zhang, Mei

    2015-01-01

    This is a study of the treatment of library patron privacy in licenses for electronic journals in academic libraries. We begin by distinguishing four facets of privacy and intellectual freedom based on the LIS and philosophical literature. Next, we perform a content analysis of 42 license agreements for electronic journals, focusing on terms for…

  13. The Prevalence and Effects of Occupational Licensing. NBER Working Paper No. 14308

    Science.gov (United States)

    Kleiner, Morris M.; Krueger, Alan B.

    2008-01-01

    This study provides the first nation-wide analysis of the labor market implications of occupational licensing for the U.S. labor market, using data from a specially designed Gallup survey. We find that in 2006, 29 percent of the workforce was required to hold an occupational license from a government agency, which is a higher percentage than that…

  14. Driving Cessation Anno 2010 Which Older Drivers Give Up Their License and Why? Evidence From Denmark

    DEFF Research Database (Denmark)

    Siren, Anu Kristiina; Haustein, Sonja

    2016-01-01

    renew their licenses. The results partly recapture the findings of earlier studies. However, in contrast to former cohorts, a much higher percentage of older drivers intended to keep their licenses. The strongest factors predicting the intention to renew were active car use, feeling safe as a driver...

  15. 78 FR 7438 - Prospective Grant of Exclusive License: Development of Human Monoclonal Antibodies Against DR4

    Science.gov (United States)

    2013-02-01

    ... HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive License: Development of... America. The prospective start-up exclusive commercial license territory may be worldwide and the field of... antibodies could be used as a research tool for the study of DR4. The prospective start-up...

  16. Driving Cessation Anno 2010 Which Older Drivers Give Up Their License and Why? Evidence From Denmark

    DEFF Research Database (Denmark)

    Siren, Anu Kristiina; Haustein, Sonja

    2016-01-01

    This study focuses on the decision to either stop or continue driving among a cohort of Danish seniors whose driving licenses expire, for the first time, at the age of 70. Based on 1,537 standardized telephone interviews with licensed drivers, we compared persons who intended to renew or not to...

  17. Braneworld physics from the analog-gravity perspective

    CERN Document Server

    Barcelo, C; Barcelo, Carlos; Campos, Antonio

    2003-01-01

    We study Randall-Sundrum brane models from the viewpoint of condensed matter/quantum optics. Following the idea of analog gravity we obtain effective metrics in fluid and Bose-Einstein-condensate systems mimicking those in the brane framework. We see that the effect of warp factors in the bulk geometry translates into finite-size of the analog systems. We stress that many open questions in braneworld physics can benefit from the understanding of critical phenomena of surfaces in finite analog systems.

  18. Backtracking quantum trajectories with analog feedback

    Science.gov (United States)

    de Lange*, G.; Ristè*, D.; Tiggelman, M. J.; Eichler, C.; Tornberg, L.; Johansson, G.; Wallraff, A.; Schouten, R. N.; Dicarlo, L.

    2014-03-01

    Circuit quantum electrodynamics offers a nearly ideal platform for the fundamental study of continuous quantum measurement. A nondemolition measurement of a superconducting qubit can be performed via homodyne detection of microwave transmission through a dispersively coupled cavity. By boosting the homodyne signal with a nearly noiseless phase-sensitive parametric amplifier, we experimentally show that a form of measurement backaction, consisting of stochastic quantum phase kicks on the measured qubit, is highly correlated with the fluctuations in the continuous homodyne record. We demonstrate a real-time analog feedback scheme that counteracts these phase kicks and thereby reduces measurement-induced dephasing. We develop a numerical optimization technique to overcome the bandwidth limitations of the amplification chain and provide a theoretical model for the optimization result. A quantum efficiency of 50% is extracted for the complete analog feedback loop. Finally, we discuss the integration of this analog feedback technique to improve performance in our recent demonstration of entanglement by dispersive parity measurement. *equal contribution. Research funded by NWO and the EU projects SOLID and SCALEQIT.

  19. Finnish experiences on licensing and using of programmable digital systems in nuclear power plants

    International Nuclear Information System (INIS)

    Finnish utility companies, Imatran Voima Oy (IVO) and Teollisuuden Voima (TVO), and the licensing authority, the Finnish Centre for Radiation and Nuclear Safety (STUK), are preparing for a new nuclear power plant in Finland. Plant vendors are proposing programmable digital automation systems for both the safety-related and the operational I and C (instrumentation and control) systems in this new unit. Also in existing plant units the replacement of certain old analog systems with state-of-the-art digital ones will become necessary in the years to come. Licensing of programmable systems for safety critical applications requires a new approach due to the special properties and failure modes of these systems. The major difficulties seem to be in the assessment and quantification of software reliability. The Technical Research Centre of Finland has in co-operation with the authority and the utilities conducted a project (AJA) to develop domestically applicable licensing requirements, guidelines and practices. International standards, guidelines and licensing practices have been analyzed in order to specify national licensing requirements. The paper describes and discusses the findings and experiences of the AJA project so far. The experience in introducing advanced programmable digital control and computer systems in the operating nuclear power plants will be covered briefly. Although these systems are not safety-related but systems of more general interest regarding nuclear safety, some routines regarding the licensing of safety- related systems have been followed. In these backfitting and replacement projects some experience have been gained in how to license safety-related programmable systems. (Author) 31 refs., 2 figs

  20. Set of criteria for licensing procedures

    International Nuclear Information System (INIS)

    A general model of licensing procedures thought to be the most appropriate for small countries is discussed. Because of the similarities in the administration and economy of small countries, the licensing process proceeds on a step-by-step basis and the licensing procedures, as one of the steps in the is process, consists of two parts: a pre-licensing period and the main part, i.e. issuing of the license. A detailed discussion of the directives of the nuclear authority for the selection of the site for a nuclear facility is provided, together with some remarks on the directives for the other licensing procedures. The licensee has to provide a special answer in a specific case which need not agree strictly with the general directives. However, the licensee is required to give a detailed explanation of the other case. (author). 4 figs

  1. Licensing new uranium production projects in Argentina

    International Nuclear Information System (INIS)

    Due to the decision to complete construction and begin operation of the Atucha II Plant, Argentina's nuclear reactor fuel requirements will increase in the mid-term from 120 tU/year to 220 tU/year. Current market conditions justify reactivation of indigenous production of uranium concentrates that could progressively replace imports. Consequently, CNEA presented to the Mendoza Province and national (Nuclear Regulatory Authority) licensing authorities a proposal for reactivation of the San Rafael Mining-Milling Complex. The main step in the licensing process is the Environmental Impact Assessment (EIA). This includes both assessment of the engineering for remediation of waste generated during previous production activities, and of environmental management of future production activities. The EIA was carried out by the National Technological University. The Cerro Solo Project, Chubut Province, which is currently at the pre-feasibility stage, is being considered for initiation of the feasibility study and development-production stage. Under present market conditions, the estimated project production cost has become competitive, and the resources of the project could be sufficient to supply the long-term needs of Argentina's nuclear power plants. Taking into account the increasing interest in environmental issues, and stricter environmental regulations, the main challenges to re-activation of uranium production in Argentina are: improvement of interaction with local communities; training of skilled personnel in waste management; and developing cost estimates and plans for mine-mill closure. (author)

  2. Technology Spillover and Licensing Strategy of Patentee

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The optimal license proportions with and without technology spillover are analyzed with a game-theoretical approach when a patent-holding firm licensed non-drastic process innovation to his incumbent rivals by means of a first price sealed bid auction. The optimal strategy is obtained through solving the game by backward induction. It is found that the range of optimal license proportion is narrower when there is spillover compared to the no spillover case.

  3. Licensing documentation and licensing process for dismantling and decontamination projects in Lithuania

    Energy Technology Data Exchange (ETDEWEB)

    Uspuras, Eugenijus; Rimkevicius, Sigitas; Babilas, Egidijus [Lithuanian Energy Institute (LEI), Kaunas (Lithuania)

    2013-07-01

    One of the main tasks of any decommissioning project is the licensing process which allows implementation of developed strategies in real NPP. The Lithuanian laws on nuclear energy and on radioactive waste management require that the dismantling and decontamination (D and D) projects shall be licensed by the Lithuanian State Nuclear Power Safety Inspectorate (VATESI) and other Authorities. Licensing is an inseparable part of the Lithuania regulatory and supervisory system for safety of nuclear facilities. The licensing process starts when NPP submits the first licensing document(s) to the Authorities. It is completed when all the licensing documents are approved by the Authorities and authorization to start D and D works is received by NPP. Current paper will discuss one of the main steps in D and D projects implementation process - Licensing and will provide information about D and D licensing approach used in Lithuania. (orig.)

  4. Licensing documentation and licensing process for dismantling and decontamination projects in Lithuania

    International Nuclear Information System (INIS)

    One of the main tasks of any decommissioning project is the licensing process which allows implementation of developed strategies in real NPP. The Lithuanian laws on nuclear energy and on radioactive waste management require that the dismantling and decontamination (D and D) projects shall be licensed by the Lithuanian State Nuclear Power Safety Inspectorate (VATESI) and other Authorities. Licensing is an inseparable part of the Lithuania regulatory and supervisory system for safety of nuclear facilities. The licensing process starts when NPP submits the first licensing document(s) to the Authorities. It is completed when all the licensing documents are approved by the Authorities and authorization to start D and D works is received by NPP. Current paper will discuss one of the main steps in D and D projects implementation process - Licensing and will provide information about D and D licensing approach used in Lithuania. (orig.)

  5. Analog circuit design art, science and personalities

    CERN Document Server

    Williams, Jim

    1991-01-01

    This book is far more than just another tutorial or reference guide - it's a tour through the world of analog design, combining theory and applications with the philosophies behind the design process. Readers will learn how leading analog circuit designers approach problems and how they think about solutions to those problems. They'll also learn about the `analog way' - a broad, flexible method of thinking about analog design tasks.A comprehensive and useful guide to analog theory and applications. Covers visualizing the operation of analog circuits. Looks at how to rap

  6. Initiatives in transport cask licensing

    International Nuclear Information System (INIS)

    The variations in research reactor fuel form, configuration, irradiation characteristics, and transport cask have required a substantial number of transport cask licensing actions associated with foreign research reactor spent fuel transportation. When compounded by limited time for shipment preparations, due to contract timing or delayed receipt of technical data, the number and timing of certifications has adversely impacted the ability of regulatory agencies to support intended shipping schedules. This issue was brought into focus at a april, 1998 meeting among DOE, the US Nuclear Regulatory Commission, and DOE's spent fuel transportation contractors. (author)

  7. Vehicle License Plate Recognition Syst

    Directory of Open Access Journals (Sweden)

    Meenakshi,R. B. Dubey

    2012-12-01

    Full Text Available The vehicle license plate recognition system has greater efficiency for vehicle monitoring in automatic zone access control. This Plate recognition system will avoid special tags, since all vehicles possess a unique registration number plate. A number of techniques have been used for car plate characters recognition. This system uses neural network character recognition and pattern matching of characters as two character recognition techniques. In this approach multilayer feed-forward back-propagation algorithm is used. The performance of the proposed algorithm has been tested on several car plates and provides very satisfactory results.

  8. Vehicle License Plate Recognition System

    Directory of Open Access Journals (Sweden)

    Meenakshi

    2012-12-01

    Full Text Available The vehicle license plate recognition system has greater efficiency for vehicle monitoring in automatic zone access control. This Plate recognition system will avoid special tags, since all vehicles possess a unique registration number plate. A number of techniques have been used for car plate characters recognition. This system uses neural network character recognition and pattern matching of characters as two character recognition techniques. In this approach multilayer feed-forward back-propagation algorithm is used. The performance of the proposed algorithm has been tested on several car plates and provides very satisfactory results.

  9. Initiatives in transport cask license

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, John [NAC International, Aiken, SC (United States). Foreign Research Reactor Liaison]. E-mail: nacaiken@aol.com

    1998-07-01

    The variations in research reactor fuel form, configuration, irradiation characteristics, and transport cask have required a substantial number of transport cask licensing actions associated with foreign research reactor spent fuel transportation. When compounded by limited time for shipment preparations, due to contract timing or delayed receipt of technical data, the number and timing of certifications has adversely impacted the ability of regulatory agencies to support intended shipping schedules. This issue was brought into focus at a april, 1998 meeting among DOE, the US Nuclear Regulatory Commission, and DOE's spent fuel transportation contractors. (author)

  10. Spaceflight Sensorimotor Analogs: Simulating Acute and Adaptive Effects

    Science.gov (United States)

    Taylor, Laura C.; Harm, Deborah L.; Kozlovskaya, Inessa; Reschke, Millard F.; Wood, Scott J.

    2009-01-01

    Adaptive changes in sensorimotor function during spaceflight are reflected by spatial disorientation, motion sickness, gaze destabilization and decrements in balance, locomotion and eye-hand coordination that occur during and following transitions between different gravitational states. The purpose of this study was to conduct a meta-synthesis of data from spaceflight analogs to evaluate their effectiveness in simulating adaptive changes in sensorimotor function. METHODS. The analogs under review were categorized as either acute analogs used to simulate performance decrements accompanied with transient changes, or adaptive analogs used to drive sensorimotor learning to altered sensory feedback. The effectiveness of each analog was evaluated in terms of mechanisms of action, magnitude and time course of observed deficits compared to spaceflight data, and the effects of amplitude and exposure duration. RESULTS. Parabolic flight has been used extensively to examine effects of acute variation in gravitational loads, ranging from hypergravity to microgravity. More recently, galvanic vestibular stimulation has been used to elicit acute postural, locomotor and gaze dysfunction by disrupting vestibular afferents. Patient populations, e.g., with bilateral vestibular loss or cerebellar dysfunction, have been proposed to model acute sensorimotor dysfunction. Early research sponsored by NASA involved living onboard rotating rooms, which appeared to approximate the time course of adaptation and post-exposure recovery observed in astronauts following spaceflight. Exposure to different bed-rest paradigms (6 deg head down, dry immersion) result in similar motor deficits to that observed following spaceflight. Shorter adaptive analogs have incorporated virtual reality environments, visual distortion paradigms, exposure to conflicting tilt-translation cues, and exposure to 3Gx centrifugation. As with spaceflight, there is considerable variability in responses to most of the analogs

  11. Texas site selection and licensing status

    Energy Technology Data Exchange (ETDEWEB)

    Avant, R.V. Jr.

    1989-11-01

    Texas has identified a potential site in Hudspeth County in far West Texas near the town of Fort Hancock. Over the past year the Texas Low-Level Radioactive Waste Disposal Authority has been conducting detailed geology, hydrology, meteorology, soils, and flora and fauna evaluations. An authorization by the Board of Directors of the Authority to proceed with a license application, assuming that the detailed evaluation indicates that the site is suitable, is expected by September. A prototype license has been prepared in anticipation of the order to proceed with licensing, and the formal license application is expected to be submitted to the Texas Department of Health-Bureau of Radiation Control in December, meeting the license application milestone. Although site selection processes in all siting areas across the country have experienced organized opposition, El Paso County has funded a particularly well-organized, well-financed program to legally and technically stop consideration of the Fort Hancock site prior to the licensing process. Many procedural, regulatory, and technical issues have been raised which have required responses from the Authority in order to proceed with licensing. This has provided a unique perspective of what to expect from well-organized opposition at the licensing stage. This paper presents an update on the Texas siting activity with detailed information on the site evaluation and license application. Experience of dealing with issues raised by opposition relating to NRC guidelines and rules is also discussed.

  12. Licensing Electronic Content in Today's Information Marketplace

    Science.gov (United States)

    Okerson, Ann

    This session will develop topics such as: what is a license, what is a shrinkwrap license and is it binding, how do licenses or contracts relate to national copyright laws, what is a good negotiating stance, what to look for in a license (key issues), and where to look for more information. The session will be outlined by a series of overheads that can help to guide the library professional who needs to work through these matters during the course of negotiating for electronic information content. The article contains the text of the transparencies shown during the presentation.

  13. Overview of the Yucca Mountain Licensing Process

    International Nuclear Information System (INIS)

    This paper presents an overview of the licensing process for a Yucca Mountain repository for high-level radioactive waste and spent nuclear fuel. The paper discusses the steps in the licensing proceeding, the roles of the participants, the licensing and hearing requirements contained in the Code of Federal Regulations. A description of the Nuclear Regulatory Commission (NRC) staff acceptance and compliance reviews of the Department of Energy (DOE) application for a construction authorization and a license to receive and possess high-level radioactive waste and spent nuclear fuel is provided. The paper also includes a detailed description of the hearing process

  14. Folding model study of the charge-exchange scattering to the isobaric analog state and implication for the nuclear symmetry energy

    Energy Technology Data Exchange (ETDEWEB)

    Khoa, Dao T.; Thang, Dang Ngoc [VINATOM, Institute for Nuclear Science and Technique, Hanoi (Viet Nam); Loc, Bui Minh [VINATOM, Institute for Nuclear Science and Technique, Hanoi (Viet Nam); University of Pedagogy, Ho Chi Minh City (Viet Nam)

    2014-02-15

    The Fermi transition (ΔL = ΔS = 0 and ΔT = 1) between the nuclear isobaric analog states (IAS), induced by the charge-exchange (p, n) or ({sup 3}He, t) reaction, can be considered as ''elastic'' scattering of proton or {sup 3}He by the isovector term of the optical potential (OP) that flips the projectile isospin. The accurately measured (p, n) or ({sup 3}He, t) scattering cross section to the IAS can be used, therefore, to probe the isospin dependence of the proton or {sup 3}He optical potential. Within the folding model, the isovector part of the OP is determined exclusively by the neutron-proton difference in the nuclear densities and the isospin dependence of the effective nucleon-nucleon (NN) interaction. Because the isovector coupling explicitly links the isovector part of the proton or {sup 3}He optical potential to the cross section of the charge-exchange (p, n) or ({sup 3}He, t) scattering to the IAS, the isospin dependence of the effective (in-medium) NN interaction can be well tested in the folding model analysis of these charge-exchange reactions. On the other hand, the same isospin- and density-dependent NN interaction can also be used in a Hartree-Fock calculation of asymmetric nuclear matter, to estimate the nuclear matter energy and its asymmetry part (the nuclear symmetry energy). As a result, the fine-tuning of the isospin dependence of the effective NN interaction against the measured (p, n) or ({sup 3}He, t) cross sections should allow us to make some realistic prediction of the nuclear symmetry energy and its density dependence. (orig.)

  15. 10 CFR 52.173 - Duration of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Duration of manufacturing license. 52.173 Section 52.173... POWER PLANTS Manufacturing Licenses § 52.173 Duration of manufacturing license. A manufacturing license... issuance. A holder of a manufacturing license may not initiate the manufacture of a reactor less than...

  16. 10 CFR 52.105 - Transfer of combined license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Transfer of combined license. 52.105 Section 52.105 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.105 Transfer of combined license. A combined license may be transferred...

  17. Energy Harvesting Using an Analog Circuit under Multimodal Vibration

    OpenAIRE

    Shigeru Shimose; Kanjuro Makihara; Junjiro Onoda

    2013-01-01

    The efficiency of harvesting energy from a vibrating structure using a piezoelectric transducer and a simple analog circuit is investigated experimentally. This analog circuit was originally invented for a synchronized switch damping on inductor (SSDI) technique, which enhances the damping of mechanical vibration. In this study, the circuit is used to implement a synchronized switch harvesting on inductor (SSHI) technique. A multiple degree of freedom (MDOF) structure is excited by single sin...

  18. Presence of organophosphorus pesticide oxygen analogs in air samples

    OpenAIRE

    Armstrong, Jenna L.; Fenske, Richard A; Yost, Michael G.; Galvin, Kit; Tchong-French, Maria; Yu, Jianbo

    2013-01-01

    A number of recent toxicity studies have highlighted the increased potency of oxygen analogs (oxons) of several organophosphorus (OP) pesticides. These findings were a major concern after environmental oxons were identified in environmental samples from air and surfaces following agricultural spray applications in California and Washington State. This paper reports on the validity of oxygen analog measurements in air samples for the OP pesticide, chlorpyrifos. Controlled environmental and lab...

  19. Benefit of Analog, Programmable and Digital Hearing Aids

    OpenAIRE

    Jamileh Fatahi; Mansoureh Adel Ghahraman; Azadeh Ebrahimi; Faranak Ehsani; Samaneh Pourhadi

    2006-01-01

    Background and Aims: As the hearing aid technology progressively promotes toward replacing analog hearing aids with digital and programmable ones, comparison of the patient satisfaction of those kinds of hearing aids by means of a valuable tool seems so necessary. So, the aim of this study was to compare self-reported benefit of analog, digitally controlled programmable and digital hearing aids for reducing disability caused by hearing impairment in mild to severe sensorineural hearing impair...

  20. Deficits in analogical reasoning in adolescents with traumatic brain injury

    OpenAIRE

    Krawczyk, Daniel C.; Gerri Hanten; Elisabeth A. Wilde; Levin, Harvey S.

    2010-01-01

    Individuals with traumatic brain injury (TBI) exhibit deficits in executive control, which may impact their reasoning abilities. Analogical reasoning requires working memory and inhibitory abilities. In this study, we tested adolescents with moderate to severe TBI and typically-developing (TD) controls on a set of picture analogy problems. Three factors were varied: complexity (number of relations in the problems), distraction (distractor item present or absent), and animacy (living or non-li...

  1. Deficits in Analogical Reasoning in Adolescents with Traumatic Brain Injury

    OpenAIRE

    Krawczyk, Daniel C.; Hanten, Gerri; Elisabeth A. Wilde; Li, Xiaoqi; Schnelle, Kathleen P.; Merkley, Tricia L.; Vasquez, Ana C.; Cook, Lori G.; McClelland, Michelle; Chapman, Sandra B.; Levin, Harvey S.

    2010-01-01

    Individuals with traumatic brain injury (TBI) exhibit deficits in executive control, which may impact their reasoning abilities. Analogical reasoning requires working memory and inhibitory abilities. In this study, we tested adolescents with moderate to severe TBI and typically developing (TD) controls on a set of picture analogy problems. Three factors were varied: complexity (number of relations in the problems), distraction (distractor item present or absent), and animacy (living or non-li...

  2. Licensed Practical Nurses in Occupational Health. An Initial Survey.

    Science.gov (United States)

    Lee, Jane A.; And Others

    The study, conducted in 1971, assessed characteristics of licensed practical nurses (LPN's) who worked in occupational health nursing. The survey instrument, a questionnaire, was returned by 591 LPN's in occupational health and provided data related to: personal characteristics, work and setting, administrative and professional functioning,…

  3. Licensing systems and inspection of nuclear installations 1991

    International Nuclear Information System (INIS)

    This revised and updated study provides a description of the nuclear licensing regulations and practices applied in OECD countries with specific provisions in that field. The national systems have been described according to a standard format to facilitate comparisons and research. In most cases, the descriptions are supplemented by flow charts illustrating the procedures and specifying the different authorities involved

  4. 76 FR 38463 - SAFE Mortgage Licensing Act: Minimum Licensing Standards and Oversight Responsibilities

    Science.gov (United States)

    2011-06-30

    ... On December 15, 2009, at 74 FR 66548, HUD published a proposed rule to clarify HUD's responsibilities... Mortgage Licensing Act: Minimum Licensing Standards and Oversight Responsibilities; Final Rule #0;#0...: Minimum Licensing Standards and Oversight Responsibilities AGENCY: Office of the Assistant Secretary...

  5. Synaptic dynamics in analog VLSI.

    Science.gov (United States)

    Bartolozzi, Chiara; Indiveri, Giacomo

    2007-10-01

    Synapses are crucial elements for computation and information transfer in both real and artificial neural systems. Recent experimental findings and theoretical models of pulse-based neural networks suggest that synaptic dynamics can play a crucial role for learning neural codes and encoding spatiotemporal spike patterns. Within the context of hardware implementations of pulse-based neural networks, several analog VLSI circuits modeling synaptic functionality have been proposed. We present an overview of previously proposed circuits and describe a novel analog VLSI synaptic circuit suitable for integration in large VLSI spike-based neural systems. The circuit proposed is based on a computational model that fits the real postsynaptic currents with exponentials. We present experimental data showing how the circuit exhibits realistic dynamics and show how it can be connected to additional modules for implementing a wide range of synaptic properties. PMID:17716003

  6. Mechanical Analogies of Fractional Elements

    Institute of Scientific and Technical Information of China (English)

    HU Kai-Xin; ZHU Ke-Qin

    2009-01-01

    A Fractional element model describes a special kind of viscoelastic material.Its stress is proportional to the fractional-order derivative of strain. Physically the mechanical analogies of fractional elements can be represented by spring-dashpot fractal networks. We introduce a constitutive operator in the constitutive equations of viscoelastic materials.To derive constitutive operators for spring-dashpot fractal networks, we use Heaviside operational calculus, which provides explicit answers not otherwise obtainable simply.Then the series-parallel formulas for the constitutive operator are derived. Using these formulas, a constitutive equation of fractional element with 1/2-order derivative is obtained.Finally we find the way to derive the constitutive equations with other fractional-order derivatives and their mechanical analogies.

  7. Bottomed analog of Z+(4433)

    International Nuclear Information System (INIS)

    The newly observed Z+(4433) resonance by BELLE is believed to be a tetraquark bound state made up of (cu)(cd). We propose the bottomed analog of this bound state, namely, by replacing one of the charm quarks by a bottom quark, thus forming Zbc0,±,±±. One of the Zbc is doubly charged. The predicted mass of Zbc is around 7.6 GeV. This doubly charged bound state can be detected by its decay into Bc±π±. Similarly, we can also replace both charm quark and antiquark of the Z+(4433) by bottom quark and antiquark, respectively, thus forming Zbb the bottomonium analog of Z+(4433). The predicted mass of Zbb is about 10.7 GeV

  8. Analog Nonvolatile Computer Memory Circuits

    Science.gov (United States)

    MacLeod, Todd

    2007-01-01

    In nonvolatile random-access memory (RAM) circuits of a proposed type, digital data would be stored in analog form in ferroelectric field-effect transistors (FFETs). This type of memory circuit would offer advantages over prior volatile and nonvolatile types: In a conventional complementary metal oxide/semiconductor static RAM, six transistors must be used to store one bit, and storage is volatile in that data are lost when power is turned off. In a conventional dynamic RAM, three transistors must be used to store one bit, and the stored bit must be refreshed every few milliseconds. In contrast, in a RAM according to the proposal, data would be retained when power was turned off, each memory cell would contain only two FFETs, and the cell could store multiple bits (the exact number of bits depending on the specific design). Conventional flash memory circuits afford nonvolatile storage, but they operate at reading and writing times of the order of thousands of conventional computer memory reading and writing times and, hence, are suitable for use only as off-line storage devices. In addition, flash memories cease to function after limited numbers of writing cycles. The proposed memory circuits would not be subject to either of these limitations. Prior developmental nonvolatile ferroelectric memories are limited to one bit per cell, whereas, as stated above, the proposed memories would not be so limited. The design of a memory circuit according to the proposal must reflect the fact that FFET storage is only partly nonvolatile, in that the signal stored in an FFET decays gradually over time. (Retention times of some advanced FFETs exceed ten years.) Instead of storing a single bit of data as either a positively or negatively saturated state in a ferroelectric device, each memory cell according to the proposal would store two values. The two FFETs in each cell would be denoted the storage FFET and the control FFET. The storage FFET would store an analog signal value

  9. High fluid intelligence and analogical reasoning

    OpenAIRE

    Preusse, Franziska

    2011-01-01

    Hitherto, previous studies on the cerebral correlates of fluid intelligence (fluIQ) used tasks that did not exclusively demand fluIQ, or were restricted to participants of average fluIQ (ave-fluIQ) solving intelligence test items of varying difficulty, thus not allowing assumptions on interindividual differences in fluIQ. Geometric analogical reasoning (GAR) demands fluIQ very purely and thus is an eligible approach for research on interindividual differences in fluIQ. In a first study, we ...

  10. Reproductive 'surrogacy' and parental licensing.

    Science.gov (United States)

    Overall, Christine

    2015-06-01

    A serious moral weakness of reproductive 'surrogacy' is that it can be harmful to the children who are created. This article presents a proposal for mitigating this weakness. Currently, the practice of commercial 'surrogacy' operates only in the interests of the adults involved (the gestator and the commissioning individuals who employ her), not in the interests of the child who is created. Whether 'surrogacy' is seen as the purchase of a baby, the purchase of parental rights, or the purchase of reproductive labor, all three views share the same significant flaws. They endorse the transfer, for a fee, of the infant from the woman who gestated it to those who commissioned it, but without justifying such a transfer; they fail to demonstrate that the commissioners have any entitlement to the infant, or, for that matter, suitability to be the infant's parents; and they fail to take any notice of the infant's needs, interests, and wellbeing. A mere genetic connection is not enough to establish that the commissioners are entitled to receive the baby or that they are competent to raise it. Their good intentions, however caring, are not enough. Therefore, just as in the practice of adoption, there should be a formal institutionalized system for screening and licensing the prospective social parents, which would make the infant's needs, interests, and wellbeing paramount. I reply to several potential objections to this proposal, including the objection that genetic parents who raise their own child are not screened and licensed. PMID:25082172

  11. Cask development, testing, and licensing

    International Nuclear Information System (INIS)

    The NuPac 125-B Rail Cask was developed to provide a safe means of transporting the damaged core of Three Mile Island Unit 2 from the TMI site at Middletown, PA, to the Idaho National Engineering laboratory (INEL) at Idaho Falls, ID. The development of the NuPac 125-B Rail Cask posed two engineering and technical management challenges; Licensing Strategy - The NuPac 125-B Rail Cask represented the first irradiated fuel rail cask developed within the United States in the past decade, a decade characterized by changing nuclear regulations, and Accelerated Schedule - The TMI-2 defueling schedule demanded a cask development schedule one-third as long as normally required. These challenges governed the overall development and licensing process for the cask. First, a high degree of conservation was incorporated into the design to allow quick, simplified demonstrations of adequacy to regulatory staff. Second, redundant design techniques were employed in all areas of uncertainty. The testing program eliminated performance uncertainties and validated predictions and predictive models. Drop tests of a quarter-scale model of the cask were conducted, and results were correlated with analytic predictions to verify structural and mechanical performance of the cask. Full-scale tests of the canisters were conducted to verify structural behavior of canister internals which provide criticality control. This paper describes the testing program for the NuPac 125-B Rail Cask, presents results therefrom, and correlates findings with Regulation 10 CFR 71 of the U.S. Nuclear Regulatory Commission

  12. Licensing process for safety-critical software-based systems

    Energy Technology Data Exchange (ETDEWEB)

    Haapanen, P. [VTT Automation, Espoo (Finland); Korhonen, J. [VTT Electronics, Espoo (Finland); Pulkkinen, U. [VTT Automation, Espoo (Finland)

    2000-12-01

    . Many of the methods and tools needed in the licensing process are still under development and further research is needed to establish a flexible and cost effective process. Also the database for the assessment methods is still inadequate. Other recently published reports in OHA-report series handle the statistical reliability assessment (STUK-YTO-TR 119), usage models (STUK-YTO-TR 128), handling of programmable automation in plant PSA-studies (STUK-YTO-TR 129)and diversity requirements (STUK-YTO-TR 142).(orig.)

  13. Licensing process for safety-critical software-based systems

    International Nuclear Information System (INIS)

    methods and tools needed in the licensing process are still under development and further research is needed to establish a flexible and cost effective process. Also the database for the assessment methods is still inadequate. Other recently published reports in OHA-report series handle the statistical reliability assessment (STUK-YTO-TR 119), usage models (STUK-YTO-TR 128), handling of programmable automation in plant PSA-studies (STUK-YTO-TR 129)and diversity requirements (STUK-YTO-TR 142).(orig.)

  14. A Postcolonial Feminist Critique of Harem Analogies in Psychological Science

    Directory of Open Access Journals (Sweden)

    Natasha Bharj

    2015-08-01

    Full Text Available Since the 1930s, psychologists have used the term harem as an analogy for social relations among animals. In doing so they draw upon gendered and racial stereotypes located in the history of colonialism. We present an experimental study on the harem analogy as a means of confronting and challenging colonial undercurrents in psychological science. We investigated whether the use of this colonialist image in studies of animal societies could subtly affect thinking about Middle Eastern Muslim people. Two-hundred and forty-nine participants read about animal societies; in the experimental condition these were described as “harems” and accompanied by the analogy of harems in Middle Eastern Muslim societies. In the two control conditions, animal societies were either described as “groups” or “harems”, with no mention of the analogy. In the experimental condition, participants falsely remembered descriptions of Muslim people of the Middle East as applying to animals. This finding replicates the “resistance is futile” effect (Blanchette & Dunbar, 2002; Perrott, Gentner, & Bodenhausen, 2005 by which false remembering of analogical statements as previously seen literal descriptions is taken as suggestive of analogical mapping between two disparate concepts. As such, the study contributes to debate between feminist and evolutionary psychology about the value-neutrality of psychology, and to postcolonial critique of the partiality of mainstream psychological accounts of the universality of nature and society.

  15. A Global Analog of Cheshire Charge

    OpenAIRE

    McGraw, Patrick

    1994-01-01

    It is shown that a model with a spontaneously broken global symmetry can support defects analogous to Alice strings, and a process analogous to Cheshire charge exchange can take place. A possible realization in superfluid He-3 is pointed out.

  16. Licensing issues associated with the use of computers in the nuclear industry

    International Nuclear Information System (INIS)

    Computers are increasingly important to ensuring the safety of nuclear power stations. They have been proposed or introduced into operator information systems, operational control systems, as well as into systems for core protection and plant protection. Although the developments in the individual countries are not at the same pace, they do tend to render similar results. Particular licensing problems arise because of the increasing complexity of computer systems and the software involved. In the past licensing has been closely connected with the mental understanding of the systems to be licensed. This understanding is endangered with greater complexity of the systems. Although several ''manual'' methods of licensing exist, the problem of cost effective licensing is still more or less unsolved. For the future it is expected that tools will reduce the licensing efforts leaving the licenser and assessor free to concentrate on the most important issues. Such tools will probably make use of artificial intelligence techniques. They will enable the inclusion of more complex functions into safety systems and thereby increase the number of safety criteria and the number of echelons od defense. Another important use of artificial intelligence techniques will be the area of operator information systems and maintenance, including computer hardware maintenance. They will provide early detection of problems in the plant and thereby largely enhance plant availability and safety. Further studies are being proposed in the fields of software licensing tools, artificial intelligence, fail-safe and fault-tolerant software architectures, test procedures and system specification

  17. Energy Harvesting Using an Analog Circuit under Multimodal Vibration

    Directory of Open Access Journals (Sweden)

    Shigeru Shimose

    2013-01-01

    Full Text Available The efficiency of harvesting energy from a vibrating structure using a piezoelectric transducer and a simple analog circuit is investigated experimentally. This analog circuit was originally invented for a synchronized switch damping on inductor (SSDI technique, which enhances the damping of mechanical vibration. In this study, the circuit is used to implement a synchronized switch harvesting on inductor (SSHI technique. A multiple degree of freedom (MDOF structure is excited by single sinusoidal forces at its resonant frequencies and by random forces. The piezoelectric transducer converts this mechanical energy into electrical energy which is harvested using a standard rectifier bridge circuit with and without our analog circuit. Experimental results show that our analog circuit makes it possible to harvest twice as much energy under both single sinusoidal and random vibration excitations.

  18. Atheism and Analogy: Aquinas Against the Atheists

    OpenAIRE

    Linford, Daniel J.

    2014-01-01

    In the 13th century, Thomas Aquinas developed two models for how humans may speak of God - either by the analogy of proportion or by the analogy of proportionality. Aquinas's doctrines initiated a theological debate concerning analogy that spanned several centuries. In the 18th century, there appeared two closely related arguments for atheism which both utilized analogy for their own purposes. In this thesis, I show that one argument, articulated by the French materialist Paul-Henri Thiry Bar...

  19. Benefit of Analog, Programmable and Digital Hearing Aids

    Directory of Open Access Journals (Sweden)

    Jamileh Fatahi

    2006-12-01

    Full Text Available Background and Aims: As the hearing aid technology progressively promotes toward replacing analog hearing aids with digital and programmable ones, comparison of the patient satisfaction of those kinds of hearing aids by means of a valuable tool seems so necessary. So, the aim of this study was to compare self-reported benefit of analog, digitally controlled programmable and digital hearing aids for reducing disability caused by hearing impairment in mild to severe sensorineural hearing impaired persons. Materials and Methods: This cross-sectional study was performed on 90 persons with mild to severe sensorineural hearing loss dividing into three groups: 43 subjects were fitted with digital, 15 with programmable, 32 with analog hearing aids. After pure tone audiometry, Abbreviated profile of hearing aid benefit (APHAB was completed before and one month after using hearing aids to determine the benefit of them. Results: Global APHAB mean scores for digital, programmable and analog hearing aids were 49.05, 33.19 and 39.53, respectively. Ease of Communication subscale mean scores were 53.46 for digitals, 37.66 for programmables and 39.09 for analogs. Background noise subscale mean scores for digital programmable and analog hearing aids were 46.36, 25.53 and 35.31, respectively. Global and also both subscale mean scores showed significant difference between digital hearing aids and programmable and analog ones. There was no significant difference between reverberation subscale mean scores of three groups. Conclusion: It seems digital hearing aids may be more beneficial to reduce disability caused by hearing loss than analog and programmable hearing aids are.

  20. 75 FR 70674 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2010-11-18

    ... valid bonds. License Number: 020760F. Name: AAA Cuban Transportation Cargo & Logistics, Inc. Address... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant...

  1. Licensing of ''grandfather's'' facilities: Ukrainian experience

    International Nuclear Information System (INIS)

    In the former USSR, unlike most countries, radioactive waste management activities including waste disposal needed no license. But after the USSR breakdown the Ukrainian Parliament -- Verkhovna Rada -- invoked the revised Law on Business activities. According to Article 4 of the Law, in order to treat or to dispose radioactive waste every enterprise has to get a special permission or license. In compliance with the Law, the Cabinet of Ministers by its Ordinance of January 13, 1993, authorized the Ukrainian State Committee for Nuclear and Radiation Safety (UkrSCNRS) to issue special permissions or licenses for waste treatment and disposal. And that requirement was valid not only for future activities but also for existing facilities in operation. Taking into account the undergoing legislative process, SCNRS began to develop its licensing process without waiting for the special nuclear laws to be passed. On the basis of the legislation already in effect, first of all the Law on Enterprises (full responsibility of enterprises for their activities) and Law on Business activities (requirement to have a license for special types of activities), the newly formed national regulatory body had to identify all the enterprises that needed to be licensed, to establish relevant procedures, to develop related regulatory documents, to implement these procedures and documents at operating enterprises, and for each case to make a decision concerning feasibility of issuing a license, period of validity and license conditions

  2. 22 CFR 96.30 - State licensing.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false State licensing. 96.30 Section 96.30 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES ACCREDITATION OF AGENCIES AND APPROVAL OF PERSONS UNDER THE INTERCOUNTRY ADOPTION ACT OF 2000 (IAA) Standards for Convention Accreditation and Approval Licensing and Corporate Governance §...

  3. NEG-shift, Licensing, and Repair Strategies

    DEFF Research Database (Denmark)

    Christensen, Ken Ramshøj

    2008-01-01

    I entertain the idea that the cross-linguistic variation in the licensing of NEG-shift, the movement of negative objects to spec-NegP, can be accounted for by a few representational constraints that are not directly related to case licensing or feature checking, and which potentially conflict wit...

  4. Licensing-In Fosters Rapid Invention!

    DEFF Research Database (Denmark)

    Leone, Maria Isabella; Reichstein, Toke

    2012-01-01

    -back clause, shifting incentives from licensee to licensor. Also, the effect is significantly reduced if the licensee is unfamiliar with the licensed technology. The effect of the grant-back clause is offset if the licensee is unfamiliar with the licensed technology, suggesting that the licensee retains the...... incentives to invent under these circumstances...

  5. 9 CFR 166.10 - Licensing.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Licensing. 166.10 Section 166.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.10 Licensing. (a) Application....

  6. 75 FR 62692 - Dairy Import Licensing Program

    Science.gov (United States)

    2010-10-13

    ... the historical license reduction provisions of the Dairy Import Licensing Program, 7 CFR part 6, for a... this proposed rule to Ron Lord, Branch Chief, Sugar and Dairy Branch, Import and Trade Support Programs... CONTACT: Ron Lord, Branch Chief, Sugar and Dairy Branch, Import and Trade Support Programs...

  7. Licensing of radioactive material (CPR Part 2)

    International Nuclear Information System (INIS)

    This Code of PAEC Regulations (CPR) part 2 sets forth the rules and regulations applicable to all persons in the Philippines governing the licensing of radioactive materials by the Philippine Nuclear Research Institute (PNRI). The following are the parts of the CPR, 1) General provisions, 2) Exceptions, 3) Licenses, 4) Records, reports, inspections and tests, and 5) Enforcement. (ELC)

  8. Licensing Teachers: Design for a Teaching Profession.

    Science.gov (United States)

    Wise, Arthur E.; And Others

    This report presents a new comprehensive design for licensing teachers. The design would require beginning teachers to complete a supervised internship as the penultimate step in the licensing process. Local school districts, operating under state guidelines, would be expected to make carefully planned internships available to all beginning…

  9. Current status of the PBMR licensing project

    International Nuclear Information System (INIS)

    The CNS is currently reviewing the PBMR conceptual design from a licensibility point of view. The PBMR concept is based on a High Temperature Gas Cooled Reactor - pebble bed reactor type. It is anticipated that the PBMR design will rely on inherent safety characteristics to contain fission products within fuel over the full range of design basis events. This feature combined with the high temperature integrity of the fuel and structural graphite, allows the safe use of a high coolant temperature, which allows consideration of the future development of this reactor for non-electrical applications of nuclear heat for industrial use. The CNS licensing approach requires that the licensing and design basis of the plant should respect prevailing international norms and practices and that a quantitative risk assessment should demonstrate compliance with the CNS fundamental safety standards. The first stage of the licensing process is now ongoing; this is a pre-application phase, which will result in a statement on licensibility being issued. Identification of the specific documentation requirements and information needed is required across every step of the licensing process. Top level regulatory requirements have been established for the PBMR. They include the CNS fundamental safety standard and basic licensing criteria, which describes requirements on licensees of nuclear installations regarding risk assessment and compliance with the safety criteria and define classification of licensing basis events. (author)

  10. Reasoning by analogy requires the left frontal pole: lesion-deficit mapping and clinical implications.

    Science.gov (United States)

    Urbanski, Marika; Bréchemier, Marie-Laure; Garcin, Béatrice; Bendetowicz, David; Thiebaut de Schotten, Michel; Foulon, Chris; Rosso, Charlotte; Clarençon, Frédéric; Dupont, Sophie; Pradat-Diehl, Pascale; Labeyrie, Marc-Antoine; Levy, Richard; Volle, Emmanuelle

    2016-06-01

    SEE BURGESS DOI101093/BRAIN/AWW092 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE  : Analogical reasoning is at the core of the generalization and abstraction processes that enable concept formation and creativity. The impact of neurological diseases on analogical reasoning is poorly known, despite its importance in everyday life and in society. Neuroimaging studies of healthy subjects and the few studies that have been performed on patients have highlighted the importance of the prefrontal cortex in analogical reasoning. However, the critical cerebral bases for analogical reasoning deficits remain elusive. In the current study, we examined analogical reasoning abilities in 27 patients with focal damage in the frontal lobes and performed voxel-based lesion-behaviour mapping and tractography analyses to investigate the structures critical for analogical reasoning. The findings revealed that damage to the left rostrolateral prefrontal region (or some of its long-range connections) specifically impaired the ability to reason by analogies. A short version of the analogy task predicted the existence of a left rostrolateral prefrontal lesion with good accuracy. Experimental manipulations of the analogy tasks suggested that this region plays a role in relational matching or integration. The current lesion approach demonstrated that the left rostrolateral prefrontal region is a critical node in the analogy network. Our results also suggested that analogy tasks should be translated to clinical practice to refine the neuropsychological assessment of patients with frontal lobe lesions. PMID:27076181

  11. Personality Factors and Nuclear Power Plant Operators: Initial License Success

    Science.gov (United States)

    DeVita-Cochrane, Cynthia

    Commercial nuclear power utilities are under pressure to effectively recruit and retain licensed reactor operators in light of poor candidate training completion rates and recent candidate failures on the Nuclear Regulatory Commission (NRC) license exam. One candidate failure can cost a utility over $400,000, making the successful licensing of new operators a critical path to operational excellence. This study was designed to discover if the NEO-PI-3, a 5-factor measure of personality, could improve selection in nuclear utilities by identifying personality factors that predict license candidate success. Two large U.S. commercial nuclear power corporations provided potential participant contact information and candidate results on the 2014 NRC exam from their nuclear power units nation-wide. License candidates who participated (n = 75) completed the NEO-PI-3 personality test and results were compared to 3 outcomes on the NRC exam: written exam, simulated operating exam, and overall exam result. Significant correlations were found between several personality factors and both written and operating exam outcomes on the NRC exam. Further, a regression analysis indicated that personality factors, particularly Conscientiousness, predicted simulated operating exam scores. The results of this study may be used to support the use of the NEO-PI-3 to improve operator selection as an addition to the current selection protocol. Positive social change implications from this study include support for the use of a personality measure by utilities to improve their return-on-investment in candidates and by individual candidates to avoid career failures. The results of this study may also positively impact the public by supporting the safe and reliable operation of commercial nuclear power utilities in the United States.

  12. eeDAP: an evaluation environment for digital and analog pathology

    Science.gov (United States)

    Gallas, Brandon D.; Cheng, Wei-Chung; Gavrielides, Marios A.; Ivansky, Adam; Keay, Tyler; Wunderlich, Adam; Hipp, Jason; Hewitt, Stephen M.

    2014-03-01

    Purpose: The purpose of this work is to present a platform for designing and executing studies that compare pathologists interpreting histopathology of whole slide images (WSI) on a computer display to pathologists interpreting glass slides on an optical microscope. Methods: Here we present eeDAP, an evaluation environment for digital and analog pathology. The key element in eeDAP is the registration of theWSI to the glass slide. Registration is accomplished through computer control of the microscope stage and a camera mounted on the microscope that acquires images of the real time microscope view. Registration allows for the evaluation of the same regions of interest (ROIs) in both domains. This can reduce or eliminate disagreements that arise from pathologists interpreting different areas and focuses the comparison on image quality. Results: We reduced the pathologist interpretation area from an entire glass slide (≈10-30 mm)2 to small ROIs google.com (project: eeDAP) as Matlab source or as a precompiled stand-alone license-free application.

  13. Early Warning of Heat/Cold Waves as a Smart City Subsystem: A Retrospective Case Study of Non-anticipative Analog methodology

    Directory of Open Access Journals (Sweden)

    Dmytro Zubov

    2015-12-01

    Full Text Available In this paper, the self-organizing inductive methodology is applied for the non-anticipative analog forecasting of the heat/cold waves in the natural environment subsystem of the smart city. The prediction algorithm is described by two paradigms. First one (short range uses quantum computing formalism. D-Wave adiabatic quantum computing Ising model is employed and evaluated for the forecasting of positive extremes of daily mean air temperature. Forecast models are designed with two to five qubits, which represent 2-, 3-, 4-, and 5-day historical data, respectively. Ising model’s real-valued weights and dimensionless coefficients are calculated using daily mean air temperatures from 119 places around the world as well as sea level (Aburatsu, Japan. The proposed forecast quantum computing algorithm is simulated based on traditional computer architecture and combinatorial optimization of Ising model parameters for the Ronald Reagan Washington National Airport dataset with 1-day lead-time on learning sample 1975-2010 yr. Analysis of the forecast accuracy (ratio of successful predictions to total number of predictions on the validation sample 2011-2014 yr shows that Ising model with three qubits has 100% accuracy, which is significant as compared to other methods. However, number of identified heat waves is small (only one out of nineteen in this case. Second paradigm (long range uses classical computation in the Microsoft Azure public cloud. Here, the forecast method identifies the dependencies between the current values of two meteorological variables and the future state of another variable. The method is applied to the prediction of heat/cold waves at Ronald Reagan Washington National Airport. The data include the above-stated datasets plus monthly mean Darwin and Tahiti sea level pressures, SOI, equatorial SOI, sea surface temperature, and multivariate ENSO index (131 datasets in total. Every dataset is split into two samples, for learning and

  14. Analog circuit design art, science, and personalities

    CERN Document Server

    Williams, Jim

    1991-01-01

    Analog Circuit Design: Art, Science, and Personalities discusses the many approaches and styles in the practice of analog circuit design. The book is written in an informal yet informative manner, making it easily understandable to those new in the field. The selection covers the definition, history, current practice, and future direction of analog design; the practice proper; and the styles in analog circuit design. The book also includes the problems usually encountered in analog circuit design; approach to feedback loop design; and other different techniques and applications. The text is

  15. Analog and mixed-signal electronics

    CERN Document Server

    Stephan, Karl

    2015-01-01

    A practical guide to analog and mixed-signal electronics, with an emphasis on design problems and applications This book provides an in-depth coverage of essential analog and mixed-signal topics such as power amplifiers, active filters, noise and dynamic range, analog-to-digital and digital-to-analog conversion techniques, phase-locked loops, and switching power supplies. Readers will learn the basics of linear systems, types of nonlinearities and their effects, op-amp circuits, the high-gain analog filter-amplifier, and signal generation. The author uses system design examples to motivate

  16. 7 CFR 735.103 - Amendments to license.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE REGULATIONS FOR WAREHOUSES REGULATIONS FOR THE UNITED STATES WAREHOUSE ACT Warehouse Licensing... licensing and examination fees; (c) Receipt of bonding or other financial assurance if required in...

  17. Cartographic distortions make dielectric spacetime analog models imperfect mimickers

    Science.gov (United States)

    Fathi, Mohsen; Thompson, Robert T.

    2016-06-01

    It is commonly assumed that if the optical metric of a dielectric medium is identical to the metric of a vacuum space-time then light propagation through the dielectric mimics light propagation in the vacuum. However, just as the curved surface of the Earth cannot be mapped into a flat plane without distortion of some surface features, so too is it impossible to project the behavior of light from the vacuum into a dielectric analog residing in Minkowski space-time without introducing distortions. We study the covariance properties of dielectric analog space-times and the kinematics of a congruence of light in the analog, and show how certain features can be faithfully emulated in the analog depending on the choice of projection, but that not all features can be simultaneously emulated without distortion. These findings indicate conceptual weaknesses in the idea of using analog space-times as a basis for transformation optics, and we show that a certain formulation of transformation optics closely related to analog space-times resolves these issues.

  18. A heat exchanger analogy of automotive paint ovens

    International Nuclear Information System (INIS)

    Computational prediction of vehicle temperatures in an automotive paint oven is essential to predict paint quality and manufacturability. The complex geometry of vehicles, varying scales in the flow, transient nature of the process, and the tightly coupled conjugate heat transfer render the numerical models computationally very expensive. Here, a novel, simplified model of the oven is developed using an analogy to a three-stream cross flow heat exchanger that transfers heat from air to a series of moving bodies and supporting carriers. The analogous heat exchanger equations are developed and solved numerically. Steady state Computational Fluid Dynamics (CFD) simulations are carried out to model the flow field and to extract the heat transfer coefficients around the body and carriers. The air temperature distribution from the CFD models is used as a boundary condition in the analogous model. Correction coefficients are used in the analogy to take care of various assumptions. These are determined from existing test data. The same corrections are used to predict air temperatures for a modified configuration of the oven and a different vehicle. The method can be used to conduct control volume analysis of ovens to determine energy efficiency, and to study new vehicle or oven designs. -- Highlights: • Analogy of an automotive paint oven as a three stream cross flow heat exchanger. • The three streams are vehicle bodies, carriers and hot air. • Convection coefficients and inlet air stream temperatures from steady CFD simulations. • Analogy useful for overall energy efficiency analysis of conveyor ovens in general

  19. Department of Energy interest and involvement in nuclear plant license renewal activities

    International Nuclear Information System (INIS)

    Recognizing the importance of nuclear license renewal to the nation's energy strategy, the Department of Energy (DOE) initiated a plant lifetime improvement program during 1985 to determine the feasibility of the license renewal option for US nuclear plants. Initial activities of the DOE program focused on determining whether there were technical and economic obstacles that might preclude or limit the successful implementation of the license renewal option. To make this determination, DOE co-sponsored with the Electric Power Research Institute (EPRI) 'pilot-plant' efforts by Virginia Electric Power and Northern States Power. Both pilot-plant efforts concluded that life extension is technically and economically feasible. In parallel with the pilot plant activities, DOE performed national economic studies that demonstrated the economic desirability of life extension. Having demonstrated the feasibility of life extension, DOE, in conjunction with EPRI, selected two lead plants to demonstrate the license renewal process. These lead plants are Yankees Atomic's Yankee Rowe facility and Northern States Power's Monticello facility. DOE also initiated activities to develop the technical and regulatory bases to support the license renewal process in the United States. These include (1) development of a methodology for identifying systems, structures, and components important to license renewal, (2) development of industry reports that describe industry-accepted approaches for license renewal of ten important classes of equipment, (3) development of technical basis to support license renewal, and (4) interaction/negotiation with the NRC through the Nuclear Management Resources Council (NUMARC) regarding appropriate regulatory requirements for license renewal. DOE has recently identified nuclear plant license renewal to be an important element of its National Energy Strategy. This paper summarizes the significant results, conclusions and ongoing activities of the DOE effort

  20. Practical analog electronics for technicians

    CERN Document Server

    Kimber, W A

    2013-01-01

    'Practical Analog Electronics for Technicians' not only provides an accessible introduction to electronics, but also supplies all the problems and practical activities needed to gain hands-on knowledge and experience. This emphasis on practice is surprisingly unusual in electronics texts, and has already gained Will Kimber popularity through the companion volume, 'Practical Digital Electronics for Technicians'. Written to cover the Advanced GNVQ optional unit in electronics, this book is also ideal for BTEC National, A-level electronics and City & Guilds courses. Together with 'Practical Digit

  1. Classical analogy of Fano resonances

    International Nuclear Information System (INIS)

    We present an analogy of Fano resonances in quantum interference to classical resonances in the harmonic oscillator system. It has a manifestation as a coupled behaviour of two effective oscillators associated with propagating and evanescent waves. We illustrate this point by considering a classical system of two coupled oscillators and interfering electron waves in a quasi-one-dimensional narrow constriction with a quantum dot. Our approach provides a novel insight into Fano resonance physics and provides a helpful view in teaching Fano resonances

  2. Field Validation of Secondary Data Sources for Enumerating Retail Tobacco Outlets in a State without Tobacco Outlet Licensing

    OpenAIRE

    D’Angelo, Heather; Fleischhacker, Sheila; Rose, Shyanika W; Ribisl, Kurt M.

    2014-01-01

    Identifying tobacco retail outlets for U.S. FDA compliance checks or calculating tobacco outlet is difficult in the 13 states without tobacco retail licensing or where licensing lists are unavailable for research. This study uses primary data collection to identify tobacco outlets in three counties in a non-licensing state and validate two commercial secondary data sources. We calculated sensitivity and positive predictive values (PPV) to validate the secondary data sources, and conducted a g...

  3. Analog modelling of obduction processes

    Science.gov (United States)

    Agard, P.; Zuo, X.; Funiciello, F.; Bellahsen, N.; Faccenna, C.; Savva, D.

    2012-04-01

    Obduction corresponds to one of plate tectonics oddities, whereby dense, oceanic rocks (ophiolites) are presumably 'thrust' on top of light, continental ones, as for the short-lived, almost synchronous Peri-Arabic obduction (which took place along thousands of km from Turkey to Oman in c. 5-10 Ma). Analog modelling experiments were performed to study the mechanisms of obduction initiation and test various triggering hypotheses (i.e., plate acceleration, slab hitting the 660 km discontinuity, ridge subduction; Agard et al., 2007). The experimental setup comprises (1) an upper mantle, modelled as a low-viscosity transparent Newtonian glucose syrup filling a rigid Plexiglas tank and (2) high-viscosity silicone plates (Rhodrosil Gomme with PDMS iron fillers to reproduce densities of continental or oceanic plates), located at the centre of the tank above the syrup to simulate the subducting and the overriding plates - and avoid friction on the sides of the tank. Convergence is simulated by pushing on a piston at one end of the model with velocities comparable to those of plate tectonics (i.e., in the range 1-10 cm/yr). The reference set-up includes, from one end to the other (~60 cm): (i) the piston, (ii) a continental margin containing a transition zone to the adjacent oceanic plate, (iii) a weakness zone with variable resistance and dip (W), (iv) an oceanic plate - with or without a spreading ridge, (v) a subduction zone (S) dipping away from the piston and (vi) an upper, active continental margin, below which the oceanic plate is being subducted at the start of the experiment (as is known to have been the case in Oman). Several configurations were tested and over thirty different parametric tests were performed. Special emphasis was placed on comparing different types of weakness zone (W) and the extent of mechanical coupling across them, particularly when plates were accelerated. Displacements, together with along-strike and across-strike internal deformation in all

  4. Analog computation with dynamical systems

    Science.gov (United States)

    Siegelmann, Hava T.; Fishman, Shmuel

    1998-09-01

    Physical systems exhibit various levels of complexity: their long term dynamics may converge to fixed points or exhibit complex chaotic behavior. This paper presents a theory that enables to interpret natural processes as special purpose analog computers. Since physical systems are naturally described in continuous time, a definition of computational complexity for continuous time systems is required. In analogy with the classical discrete theory we develop fundamentals of computational complexity for dynamical systems, discrete or continuous in time, on the basis of an intrinsic time scale of the system. Dissipative dynamical systems are classified into the computational complexity classes P d, Co-RP d, NP d and EXP d, corresponding to their standard counterparts, according to the complexity of their long term behavior. The complexity of chaotic attractors relative to regular ones leads to the conjecture P d ≠ NP d. Continuous time flows have been proven useful in solving various practical problems. Our theory provides the tools for an algorithmic analysis of such flows. As an example we analyze the continuous Hopfield network.

  5. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel J. M

    2013-01-01

    This textbook is appropriate for use in graduate-level curricula in analog to digital conversion, as well as for practicing engineers in need of a state-of-the-art reference on data converters.  It discusses various analog-to-digital conversion principles, including sampling, quantization, reference generation, nyquist architectures and sigma-delta modulation.  This book presents an overview of the state-of-the-art in this field and focuses on issues of optimizing accuracy and speed, while reducing the power level. This new, second edition emphasizes novel calibration concepts, the specific requirements of new systems, the consequences of 45-nm technology and the need for a more statistical approach to accuracy.  Pedagogical enhancements to this edition include more than twice the exercises available in the first edition, solved examples to introduce all key, new concepts and warnings, remarks and hints, from a practitioner’s perspective, wherever appropriate.  Considerable background information and pr...

  6. AVC/H.264 patent portfolio license

    Science.gov (United States)

    Skandalis, Dean A.

    2006-08-01

    MPEG LA, LLC offers a joint patent license for the AVC (a/k/a H.264) Standard (ISO/IEC IS 14496-10:2004). Like MPEG LA's other licenses, the AVC Patent Portfolio License is offered for the convenience of the marketplace as an alternative enabling users to access essential intellectual property owned by many patent holders under a single license rather than negotiating licenses with each of them individually. The AVC Patent Portfolio License includes essential patents owned by DAEWOO Electronics Corporation; Electronics and Telecommunications Research Institute (ETRI); France Telecom, societe anonyme; Fujitsu Limited; Hitachi, Ltd.; Koninklijke Philips Electronics N.V.; LG Electronics Inc.; Matsushita Electric Industrial Co., Ltd.; Microsoft Corporation; Mitsubishi Electric Corporation; Robert Bosch GmbH; Samsung Electronics Co., Ltd.; Sedna Patent Services, LLC; Sharp Kabushiki Kaisha; Siemens AG; Sony Corporation; The Trustees of Columbia University in the City of New York; Toshiba Corporation; UB Video Inc.; and Victor Company of Japan, Limited. Another is expected also to join as of August 1, 2006. MPEG LA's objective is to provide worldwide access to as much AVC essential intellectual property as possible for the benefit of AVC users. Therefore, any party that believes it has essential patents is welcome to submit them for evaluation of their essentiality and inclusion in the License if found essential.

  7. Regulation and license for NPP in Indonesia

    International Nuclear Information System (INIS)

    Any activity relating to nuclear energy shall maintain safety, security, safeguards, health worker and public as well as environmental protection, according to article 16(1) act No. 10 year 1997 on Nuclear Energy. The act No. 10 year 1997 on Nuclear Energy stipulated independent government agency as nuclear energy regulatory called BAPETEN (Nuclear Energy Regulatory Agency). BAPETEN has task to make regulation, licensing process and inspection. Bapeten shall have a licensing and inspection system in fulfilling his function to issued licensing according to Nuclear Energy Act. In Article 17 stipulated that any nuclear energy utilization or construction and operation of nuclear reactor and other nuclear installation as well as decommissioning of nuclear reactor shall have license. Requirements and process to issue license for nuclear reactor stipulated further in Government Regulation no. 43 year 2006. The purpose of the Government Regulation No. 43 is to stipulate licensing of nuclear reactor in order to assure the health of worker and public, environment protection and security of nuclear material and nuclear facility. Requirement and guidance in licensing NPP mandated by Government Regulation or Presidential Decree stipulated in Bapeten Chairman Regulation

  8. Hanau licenses voided by German state court

    International Nuclear Information System (INIS)

    On July 21, the Higher Administrative Court in the German state of Hesse declared illegal three of the first four partial construction licenses for the plutonium section of the Siemens fuel fabrication complex at Hanau. The licenses were issued in the late 1980s by the former Christian Democrat administration of Hesse, but final licensing of the plant - now 90 percent complete - has been held up by the Social Democrat/Green Party coalition government that is now in power. The court ruling came as a result of four cases, and a so-called urgent application, initiated by antinuclear groups in the area

  9. Licensed bases management for advanced nuclear plants

    International Nuclear Information System (INIS)

    Prospective Advanced Nuclear Plant (ANP) owners must have high confidence that the integrity of the licensed bases (LB) of a plant will be effectively maintained over its life cycle. Currently, licensing engineers use text retrieval systems, database managers, and checklists to access, update, and maintain vast and disparate licensing information libraries. This paper describes the demonstration of a ''twin-engine'' approach that integrates a program from the emerging class of concept searching tools with a modern Product Data Management System (PDMS) to enhance the management of LB information for an example ANP design. (author)

  10. PBMR-SA licensing project organization

    International Nuclear Information System (INIS)

    The South African nuclear regulatory authority, the Council for Nuclear Safety (CNS), is beginning the safety review of the Pebble Bed Modular Reactor (PBMR) design under development by the South African National Electrical Utility, Eskom. This paper describes the CNS licensing process, including the establishment of basic licensing criteria, general design criteria, and specific design rules, as well the safety assessment to be conducted in accordance with the established structure. It also summarises the CNS PBMR review project activities, including the overall organisational arrangements, licensing basis, safety and risk assessment, general operating rules and plant design engineering, and pre-operational testing. (author)

  11. Automatic activation of categorical and abstract analogical relations in analogical reasoning.

    Science.gov (United States)

    Green, Adam E; Fugelsang, Jonathan A; Dunbar, Kevin N

    2006-10-01

    We examined activation of concepts during analogical reasoning. Subjects made either analogical judgments or categorical judgments about four-word sets. After each four-word set, they named the ink color of a single word in a modified Stroop task. Words that referred to category relations were primed (as indicated by longer response times on Stroop color naming) subsequent to analogical judgments and categorical judgments. This finding suggests that activation of category concepts plays a fundamental role in analogical thinking. When colored words referred to analogical relations, priming occurred subsequent to analogical judgments, but not to categorical judgments, even though identical four-word stimuli were used for both types of judgments. This finding lends empirical support to the hypothesis that, when people comprehend the analogy between two items, they activate an abstract analogical relation that is distinct from the specific content items that compose the analogy. PMID:17263066

  12. Isolation and characterization of soybean NBS analogs

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Isolation of plant resistance genes is greatly helpful to crop resistance breeding and the insight of resistance mechanism. The cloned plant resistance genes are classified into four classes according to their putative structural domain, of which the majority possesses nucleotide-binding site (NBS) domain that consists of P-loop, kinase2a and kinase3a. The conservation of this domain affords the potential possibility of cloning the plant resistance genes, which is homology-based cloning technique. In the present study, the degenerate oligonucleotide primers were designed according to the tobacco N and Arabidopsis RPS2, and 358 clones were isolated from the genomic DNA of resistance soybean cultivar Kefeng1, resistant to soybean mosaic virus, and 4 open-reading NBS analogs were finally characterized and designated as KNBS1, KNBS2, KNBS3 and KNBS4. Southern hybridization suggested that they were present with multicopy in the soybean genome; KNBS4 was mapped to F linkage group and KNBS2 co-located J linkage group with the SCAR marker of Rsa resistant to soybean mosaic virus by RFLP analysis. Northern analysis suggested that KNBS2- related sequence was low and constitutively expressed in the root, stem and leaves of soybean. The detailed characterization of NBS analogs is very helpful to ultimately cloning the soybean resistance gene.

  13. The exoplanets analogy to the Multiverse

    CERN Document Server

    Kinouchi, Osame

    2015-01-01

    The idea of a Mutiverse is controversial, although it is a natural possible solution to particle physics and cosmological fine-tuning problems (FTPs). Here I explore the analogy between the Multiverse proposal and the proposal that there exist an infinite number of stellar systems with planets in a flat Universe, the Multiplanetverse. Although the measure problem is present in this scenario, the idea of a Multiplanetverse has predictive power, even in the absence of direct evidence for exoplanets that appeared since the 90s. We argue that the fine-tuning of Earth to life (and not only the fine-tuning of life to Earth) could predict with certainty the existence of exoplanets decades or even centuries before that direct evidence. Several other predictions can be made by studying only the Earth and the Sun, without any information about stars. The analogy also shows that theories that defend that the Earth is the unique existing planet and that, at the same time, is fine-tuned to life by pure chance (or pure phy...

  14. Analog IC reliability in nanometer CMOS

    CERN Document Server

    Maricau, Elie

    2013-01-01

    This book focuses on modeling, simulation and analysis of analog circuit aging. First, all important nanometer CMOS physical effects resulting in circuit unreliability are reviewed. Then, transistor aging compact models for circuit simulation are discussed and several methods for efficient circuit reliability simulation are explained and compared. Ultimately, the impact of transistor aging on analog circuits is studied. Aging-resilient and aging-immune circuits are identified and the impact of technology scaling is discussed.   The models and simulation techniques described in the book are intended as an aid for device engineers, circuit designers and the EDA community to understand and to mitigate the impact of aging effects on nanometer CMOS ICs.   ·         Enables readers to understand long-term reliability of an integrated circuit; ·         Reviews CMOS unreliability effects, with focus on those that will emerge in future CMOS nodes; ·         Provides overview of models for...

  15. Palytoxin and Analogs: Biological and Ecological Effects

    Directory of Open Access Journals (Sweden)

    Vítor Ramos

    2010-06-01

    Full Text Available Palytoxin (PTX is a potent marine toxin that was originally found in soft corals from tropical areas of the Pacific Ocean. Soon after, its occurrence was observed in numerous other marine organisms from the same ecological region. More recently, several analogs of PTX were discovered, remarkably all from species of the dinoflagellate genus Ostreopsis. Since these dinoflagellates are also found in other tropical and even in temperate regions, the formerly unsuspected broad distribution of these toxins was revealed. Toxicological studies with these compounds shows repeatedly low LD50 values in different mammals, revealing an acute toxic effect on several organs, as demonstrated by different routes of exposure. Bioassays tested for some marine invertebrates and evidences from environmental populations exposed to the toxins also give indications of the high impact that these compounds may have on natural food webs. The recognition of its wide distribution coupled with the poisoning effects that these toxins can have on animals and especially on humans have concerned the scientific community. In this paper, we review the current knowledge on the effects of PTX and its analogs on different organisms, exposing the impact that these toxins may have in coastal ecosystems.

  16. Evaluation of the Tubulin-Bound Paclitaxel Conformation: Synthesis, Biology and SAR Studies of C-4 to C-3′ Bridged Paclitaxel Analogs

    OpenAIRE

    Ganesh, Thota; Yang, Chao; Norris, Andrew,; Glass, Tom; Bane, Susan; Ravindra, Rudravajhala; Banerjee, Abhijit; Metaferia, Belhu; Thomas, Shala L.; Giannakakou, Paraskevi; Alcaraz, Ana A.; Lakdawala, Ami S.; Snyder, James P.; Kingston, David G I

    2007-01-01

    The important anticancer drug paclitaxel binds to the β-subunit of the αβ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have been made for it. In previous work we presented experimental and theoretical evidence that paclitaxel adopts a T-shaped conformation when it is bound to tubulin. In this study we report additional exp...

  17. QCD analogy for quantum gravity

    Science.gov (United States)

    Holdom, Bob; Ren, Jing

    2016-06-01

    Quadratic gravity presents us with a renormalizable, asymptotically free theory of quantum gravity. When its couplings grow strong at some scale, as in QCD, then this strong scale sets the Planck mass. QCD has a gluon that does not appear in the physical spectrum. Quadratic gravity has a spin-2 ghost that we conjecture does not appear in the physical spectrum. We discuss how the QCD analogy leads to this conjecture and to the possible emergence of general relativity. Certain aspects of the QCD path integral and its measure are also similar for quadratic gravity. With the addition of the Einstein-Hilbert term, quadratic gravity has a dimensionful parameter that seems to control a quantum phase transition and the size of a mass gap in the strong phase.

  18. The licensing dilemma: understanding the determinants of the rate of technology licensing

    OpenAIRE

    2006-01-01

    The licensing of technology entails a trade-off: licensing payments net of transaction costs (revenue effect) must be balanced against the lower price-cost margin and/or reduced market share implied by increased competition (profit dissipation effect) from the licensee. We argue that the presence of multiple technology holders, which compete in the market for technology, changes such a trade-off and triggers more aggressive licensing behavior. To test our theory, we analyze technology licensi...

  19. The annotated outlined process for a mined geologic disposal system license application

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) is studying Yucca Mountain, Nevada, as a potential site for a mined geologic repository for high-level nuclear waste. DOE has the responsibility to license the potential repository; if the site is found suitable, a license application would be submitted to the U.S. Nuclear Regulatory Commission (NRC). Current plans are to submit the license application in 2001. To manage development of the license application, DOE has developed the Mined Geologic Disposal System Annotated Outline for License Application (AO). The AO provides a method to verify the site characterization program and to implement the guidance given by the NRC in their draft regulatory guide on the license application. In addition, the AO facilities focused interactions with the NRC and will contribute to the clarification of the regulations. The development of the AO is an interactive process; revisions are produced semiannually, and transmitted to the NRC to provide information and to facilitate NRC's staff guidance to DOE. The AO is an effective method to manage the complex and challenging regulatory and technical information requirements for development of the license application

  20. Priming analogical reasoning with false memories.

    Science.gov (United States)

    Howe, Mark L; Garner, Sarah R; Threadgold, Emma; Ball, Linden J

    2015-08-01

    Like true memories, false memories are capable of priming answers to insight-based problems. Recent research has attempted to extend this paradigm to more advanced problem-solving tasks, including those involving verbal analogical reasoning. However, these experiments are constrained inasmuch as problem solutions could be generated via spreading activation mechanisms (much like false memories themselves) rather than using complex reasoning processes. In three experiments we examined false memory priming of complex analogical reasoning tasks in the absence of simple semantic associations. In Experiment 1, we demonstrated the robustness of false memory priming in analogical reasoning when backward associative strength among the problem terms was eliminated. In Experiments 2a and 2b, we extended these findings by demonstrating priming on newly created homonym analogies that can only be solved by inhibiting semantic associations within the analogy. Overall, the findings of the present experiments provide evidence that the efficacy of false memory priming extends to complex analogical reasoning problems. PMID:25784574

  1. Compulsory licenses for pharmaceuticals: an inconvenient truth?

    OpenAIRE

    Thambisetty, Sivaramjani

    2013-01-01

    LSE’s Sivaramjani Thambisetty discusses the legal and strategic implications for the pharmaceutical industry of the Indian decision to uphold the grant of the first compulsory license on a patented drug.

  2. Whom to Choose as License Partner?

    DEFF Research Database (Denmark)

    Laursen, Keld; Reichstein, Toke; Trombini, Giulia

    2013-01-01

    benefits and obviate issues related to technology transfer and knowledge recombination. At the same time, firms wish to select a partner operating in a different product market to minimize competitive downside issues and to access other product markets, skills and resources. We contend interdependence......This paper investigates the matching of firms on the market for technology. The paper forwards two dimensions along which license formation occurs: technology and product-market. Both sides of the market search for a partner representing potential for high technology synergies to maximize licensing...... between technology and market forces: if partners are market distant, the likelihood of technology license contractual partnership decreases with partners’ technological distance. Using data on the formation of license partnerships in the global biopharmaceutical industry over the period 1994-2004 the...

  3. Licensing and Certification District Offices, California

    Data.gov (United States)

    U.S. Department of Health & Human Services — This data contains a list of California Licensing and Certification District Offices. The California Department of Public Health, Center for Health Care Quality,...

  4. Licensing of HTGRs in the United States

    International Nuclear Information System (INIS)

    The licensing history of the high-temperature gas-cooled reactor (HTGR) in the United States is given historical perspective. The experience began with the licensing of the Peach Bottom Atomic Power Station and extends to the continuing experience at the Fort St. Vrain Nuclear Generating Station. Additional experience was obtained from the licensing reviews in the mid-1970s of the large HTGR plants that were to be built by Philadelphia Electric Company and Delmarva Power and Light. Also, information was provided by the licensing review of the General Atomic standard plant by the U.S. Nuclear Regulatory Commission (NRC) at about the same time. These experiences are summarized in terms of the principal design criteria that were required by the regulatory authority for each project. These criteria include specification of the design basis accidents that were postulated for the plant safety analysis. Several technical issues raised by the NRC during their review of the large HTGR are presented. (author)

  5. Visualization of License Plate Recognition System

    Directory of Open Access Journals (Sweden)

    Zhiyi Ruan

    2013-11-01

    Full Text Available The image of the license plate is located and segmented by some digital-image processing technologies such as gray-scale processing, gray-scale stretching and filtering, edge detection, morphological processing, Hough transformation etc. According to the characteristics of the license plate, binary matrix of character image sets the fuzzy matrix, and based on the principle of proximity computing space of closeness to get the fuzzy pattern recognition of characters. On the basis of the data of image pixels, the samples which are randomly selected under noisy condition and which are treated by morphological processing are randomly selected, and then the samples are used to test the simulation and identification of Back Propagation (BP Neural Networks. With the mathematical software-Matlab programming, the license plates are recognized. The aim is to develop the Visualization of user interface in License Plate Recognition System.  

  6. Licensing Opportunities for NIH, CDC & FDA Technologies

    Data.gov (United States)

    U.S. Department of Health & Human Services — This dataset represents all technologies available for licensing from the National Institutes of Health (NIH), the Food and Drug Administration (FDA), and the...

  7. 10 CFR 55.57 - Renewal of licenses.

    Science.gov (United States)

    2010-01-01

    ... Administrator specified in § 55.5(b). (3) Provide written evidence of the applicant's experience under the... 10 Energy 2 2010-01-01 2010-01-01 false Renewal of licenses. 55.57 Section 55.57 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Licenses § 55.57 Renewal of licenses. (a) The...

  8. 7 CFR 6.32 - Globalization of licenses.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Globalization of licenses. 6.32 Section 6.32 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.32 Globalization of licenses. If the Licensing Authority determines that entries of an...

  9. 78 FR 21366 - Ocean Transportation Intermediary License Revocations

    Science.gov (United States)

    2013-04-10

    ... Ocean Transportation Intermediary License Revocations The Commission gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to section 19 of the Shipping Act... 26, 2013. Reason: Voluntary Surrender of License. License No.: 022076NF. Name: KT Logistics,...

  10. 10 CFR 52.175 - Transfer of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Transfer of manufacturing license. 52.175 Section 52.175 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.175 Transfer of manufacturing license. A manufacturing...

  11. 10 CFR 52.167 - Issuance of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Issuance of manufacturing license. 52.167 Section 52.167... POWER PLANTS Manufacturing Licenses § 52.167 Issuance of manufacturing license. (a) After completing any... manufacturing license if the Commission finds that: (1) Applicable standards and requirements of the Act and...

  12. 10 CFR 51.54 - Environmental report-manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report-manufacturing license. 51.54 Section... report—manufacturing license. (a) Each applicant for a manufacturing license under subpart F of part 52... Environmental Report—Manufacturing License.” The environmental report must address the costs and benefits...

  13. 21 CFR 601.5 - Revocation of license.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Revocation of license. 601.5 Section 601.5 Food... LICENSING General Provisions § 601.5 Revocation of license. (a) A biologics license shall be revoked upon... for, and offering an opportunity for a hearing on the proposed revocation if the Commissioner...

  14. 7 CFR 58.34 - Suspension or revocation of license.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Suspension or revocation of license. 58.34 Section 58... Dairy Products Licensing of Inspectors Or Graders § 58.34 Suspension or revocation of license. For good... by any argument or evidence that he may wish to offer as to why his license should not be...

  15. 10 CFR 52.104 - Duration of combined license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Duration of combined license. 52.104 Section 52.104 Energy... Combined Licenses § 52.104 Duration of combined license. A combined license is issued for a specified... criteria are met under § 52.103(g) or allowing operation during an interim period under the...

  16. 10 CFR 52.103 - Operation under a combined license.

    Science.gov (United States)

    2010-01-01

    ... the combined license will be processed as a request for action in accordance with 10 CFR 2.206. The... 10 Energy 2 2010-01-01 2010-01-01 false Operation under a combined license. 52.103 Section 52.103... POWER PLANTS Combined Licenses § 52.103 Operation under a combined license. (a) The licensee...

  17. 10 CFR 52.109 - Continuation of combined license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Continuation of combined license. 52.109 Section 52.109... POWER PLANTS Combined Licenses § 52.109 Continuation of combined license. Each combined license for a... applicable to the facility in accordance with the NRC's regulations and the provisions of the...

  18. Analog circuit design scalable analog circuit design, high speed D/A converters, RF power amplifiers

    CERN Document Server

    Huijsing, Johan

    2007-01-01

    Preface. Part I: Scalable Analog Circuit Design. Introduction. Scalable High-Speed Analog Circuit Design; M. Vertregt, P. Scholtens. Scalable High Resolution Mixed Mode Circuit Design; R.J. Brewer. Scalable 'High Voltages' Integrated Circuit Design for XDSL Type of Applications; D. Rossi. Scalability of Wire-Line Analog Front-Ends; K. Bult. Reusable IP Analog Circuit Design; J. Hauptmann, A. Wiesbauer, H. Weinberger. Process Migration Tools for Analog and Digital Circuits; K. Francken, G. Gielen. Part II: High-Speed D/A Converters. Introduction. Introduction to High-Speed Digital-to-Analog Con

  19. The Effects of Music and Movement Opportunity on the Analogical Reasoning Performance of African American and White School Children: A Preliminary Study.

    Science.gov (United States)

    Allen, Brenda A.; Butler, Lisa

    1996-01-01

    Studies contextual factors informed by cultural experiences and their influence on learning task performance in 15 African American and 13 white children. The African American children performed better when allowed to coordinate movement and music to the learning task while white students had the opposite results. (GR)

  20. Establishing a safety and licensing basis for generation IV advanced reactors. License by test

    International Nuclear Information System (INIS)

    The license by test approach to licensing is a novel method of licensing reactors. It provides an opportunity to deal with innovative non-water reactors in a direct way on a time scale that could permit early certification based on tests of a demonstration reactor. The uncertainties in the design and significant contributors to risk would be identified in the PRA during the design. Deterministic analysis computer codes could be tested on a real reactor. Scaling effects and associated uncertainties would be minimized. License by test is an approach that has sufficient merit to be developed and tested