WorldWideScience

Sample records for analog studies licensing

  1. Natural analog studies: Licensing perspective

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J.W. [Nuclear Regulatory Commission, Washington, DC (United States)

    1995-09-01

    This report describes the licensing perspective of the term {open_quotes}natural analog studies{close_quotes} as used in CFR Part 60. It describes the misunderstandings related to its definition which has become evident during discussions at the U.S Nuclear Regulatory Commission meetings and tries to clarify the appropriate applications of natural analog studies to aspects of repository site characterization.

  2. The role of natural analogs in the repository licensing process

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, W.M. [Center for Nuclear Waste Regulatory Analyses, San Antonio, TX (United States)

    1995-09-01

    The concept of a permanent geologic repository for high-level nuclear waste (NLW) is implicitly based on analogy to natural systems that have been stable for millions or billions of years. The time of radioactive and chemical toxicity of HLW exceeds the duration of human civilization, and it is impossible to demonstrate the accuracy of predictions of the behavior of engineered or social systems over such long periods.

  3. Changing mobility patterns and road mortality among pre-license teens in a late licensing country : an epidemiological study.

    NARCIS (Netherlands)

    Twisk, D.A.M. Bos, N.M. Shope, J.T. & Kok, G.

    2013-01-01

    Whereas the safety of teens in early licensing countries has been extensively studied, little is known about the safety of pre-license teens in late licensing countries, where these teens also may be at risk. This risk exists because of the combination of a) increasing use of travel modes with a hig

  4. Phenomenological Study of Special Education Teachers Using an Emergency License

    Science.gov (United States)

    Alborn-Yilek, Susan

    2010-01-01

    The shortage of special education teachers is critical. One means used to increase the supply of available teachers is to issue an emergency license to teachers not fully certified in special education. This is a phenomenological study of four general education teachers practicing special education using an emergency license. Their experience is…

  5. Analogies as categorization phenomena: Studies from scientific discourse

    Science.gov (United States)

    Atkins, Leslie Jill

    Studies on the role of analogies in science classrooms have tended to focus on analogies that come from the teacher or curriculum, and not the analogies that students generate. Such studies are derivative of an educational system that values content knowledge over scientific creativity, and derivative of a model of teaching in which the teacher's role is to convey content knowledge. This dissertation begins with the contention that science classrooms should encourage scientific thinking and one role of the teacher is to model that behavior and identify and encourage it in her students. One element of scientific thinking is analogy. This dissertation focuses on student-generated analogies in science, and offers a model for understanding these. I provide evidence that generated analogies are assertions of categorization, and the base of an analogy is the constructed prototype of an ad hoc category. Drawing from research on categorization, I argue that generated analogies are based in schemas and cognitive models. This model allows for a clear distinction between analogy and literal similarity; prior to this research analogy has been considered to exist on a spectrum of similarity, differing from literal similarity to the degree that structural relations hold but features do not. I argue for a definition in which generated analogies are an assertion of an unexpected categorization: that is, they are asserted as contradictions to an expected schema.

  6. Natural Analog Studies at Pena Blanca, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    A.M. Simmons

    2005-07-11

    The significance of the Pena Blanca uranium deposits in the State of Chihuahua, Mexico as potential natural analogs for a nuclear waste repository in unsaturated welded tuff was first recognized in the 1980s. In the 1970s, the Pena Blanca region was a major target of uranium exploration and exploitation by the Mexican government. Since then the Nopal I uranium deposit has been studied extensively by researchers in the U.S., Mexico, and Europe. The Nopal I deposit represents an environment similar to that of the proposed high-level radioactive waste repository at Yucca Mountain in many ways. Both are located in semi-arid regions. Both are located in Tertiary rhyolitic tuffs overlying carbonate rocks that have been subjected to basin and range-style tectonic deformation. Both are located in a chemically oxidizing, unsaturated zone 200 m or more above the water table. The alteration of uraninite to secondary minerals at Nopal I may be similar to the alteration of uranium fuel rods in this type of setting. Investigations at Nopal I and in the surrounding Sierra Pena Blanca have included detailed outcrop mapping, hydrologic and isotopic studies of flow and transport, studies of mineral alteration, modeling, and performance assessment.

  7. Developing Fluorescent Hyaluronan Analogs for Hyaluronan Studies

    Directory of Open Access Journals (Sweden)

    Shi Ke

    2012-02-01

    Full Text Available Two kinds of fluorescent hyaluronan (HA analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR dye. At low labeling ratios, the hyaluronan uptake can be directly imaged while at high labeling ratios, the fluorescent signal is quenched and signal generation occurs only after degradation. It is found that the conjugate containing 1%–2% NIR dye can be used as a normal optical imaging agent, while bioactivable imaging agents are formed at 6% to 17% dye loading. It was determined that the conjugation of dye to HA with different loading percentages does not impact HA biodegradation by hyaluronidase (Hyal. The feasibility of using these two NIR fluorescent hyaluronan analogs for HA investigation was evaluated in vivo with optical imaging. The data demonstrates that the 1% dye loaded fluorescent HA can be used to monitor the behavior of HA and its fragments, whereas bioactivatable HA imaging agent (17% dye in HA is more suitable for detecting HA fragments.

  8. Licensing method for new nuclear power plant: A study on decision making modeling

    Energy Technology Data Exchange (ETDEWEB)

    Ramli, N; Ohaga, E. O.; Jung, J. C. [KEPCO International Nuclear Graduate School, Ulsan (Korea, Republic of)

    2012-10-15

    This work provides a study on decision making modeling for a licensing method of a new nuclear power plant. SWOT analysis provides the licensing alternatives attributes, then the expectation from either COL or two step licensing method is decided by inputting the output from the Hurwitz mathematical model. From the analysis, COL shows the best candidate for both optimistic and pessimistic conditions.

  9. A COMPARATIVE STUDY OF STATE LICENSING BOARDS FOR SCHOOL ADMINISTRATION AND OTHER SELECTED PROFESSIONS.

    Science.gov (United States)

    MOLINARI, RALPH G.; AND OTHERS

    COMPARISON OF THE COMPOSITION, CHARACTERISTICS, AND CURRENT LICENSING PRACTICES OF STATE LICENSING BOARDS FOR EDUCATIONAL ADMINISTRATION WITH LICENSING PROGRAMS FOR SEVEN OTHER PROFESSIONS, (ACCOUNTANCY, ARCHITECTURE, DENTISTRY, ENGINEERING, LAW, MEDICINE, AND NURSING) WAS THE PURPOSE OF THIS NATIONWIDE STUDY. THE RESEARCH PROCEDURES WERE DIVIDED…

  10. The Implementation of Integrated One-Stop Service at Licensing Service Agency in Order to Improve Licensing Service to Society (Case Study On Business License Service At Investment And Integrated Licensing Service Agency (IILSA Of Pasuruan City

    Directory of Open Access Journals (Sweden)

    Priyani Dini Pramita

    2014-10-01

    Full Text Available This study discusses about the implementation of integrated one-stop licensing services related to service of SIUP, conducted by the Investment and Integrated Licensing Service Agency (IILSA in Pasuruan City. In general there are any issues related to License for business activities, namely: the complicated procedures, high costs and legal uncertainty. To overcome this problem the government issued Permendagri number 24 of 2006 about Guidelines for the Implementation of One Stop Services. The focus of this study discusses the implementation of an integrated one-stop service, based on the rules associated with seeing some of the following elements: (1 executing actor (2 communication (3 resources (4 bureaucratic structure (5 the target group. This research used descriptive method with qualitative research approach. Activity of data analysis in this study consisted of data reduction, display and verification of data. The result of this research can be said that the implementation is done by IILSA of Pasuruan city has been good although there are a few things that need to be improved related to the internet connection is still an obstacle in the implementation of the operational in the delivery service for SIUP and also the lack of facilities and infrastructure available. Keywords: IILSA of Pasuruan City, Licensing Service, SIUP (Business License, Improve Service, The Implementation.

  11. Lunar Analog

    Science.gov (United States)

    Cromwell, Ronita L.

    2009-01-01

    In this viewgraph presentation, a ground-based lunar analog is developed for the return of manned space flight to the Moon. The contents include: 1) Digital Astronaut; 2) Bed Design; 3) Lunar Analog Feasibility Study; 4) Preliminary Data; 5) Pre-pilot Study; 6) Selection of Stockings; 7) Lunar Analog Pilot Study; 8) Bed Design for Lunar Analog Pilot.

  12. Application of natural analog studies to exploration for ore deposits

    Energy Technology Data Exchange (ETDEWEB)

    Gustafson, D.L. [Consulting Economic Geologist, Reno, NV (United States)

    1995-09-01

    Natural analogs are viewed as similarities in nature and are routinely utilized by exploration geologists in their search for economic mineral deposits. Ore deposit modeling is undertaken by geologists to direct their exploration activities toward favorable geologic environments and, therefore, successful programs. Two types of modeling are presented: (i) empirical model development based on the study of known ore deposit characteristics, and (ii) concept model development based on theoretical considerations and field observations that suggest a new deposit type, not known to exist in nature, may exist and justifies an exploration program. Key elements that are important in empirical model development are described, and examples of successful applications of these natural analogs to exploration are presented. A classical example of successful concept model development, the discovery of the McLaughlin gold mine in California, is presented. The utilization of natural analogs is an important facet of mineral exploration. Natural analogs guide explorationists in their search for new discoveries, increase the probability of success, and may decrease overall exploration expenditure.

  13. Study on CCR5 analogs and affinity peptides.

    Science.gov (United States)

    Wu, Yingping; Deng, Riqiang; Wu, Wenyan

    2012-03-01

    The G protein-coupled receptor of human chemokine receptor 5 (CCR5) is a key target in the human immunodeficiency virus (HIV) infection process due to its major involvement in binding to the HIV type 1 (HIV-1) envelope glycoprotein gp120 and facilitating virus entry into the cells. The identification of naturally occurring CCR5 mutations (especially CCR5 delta-32) has allowed us to address the CCR5 molecule as a promising target to prevent or resist HIV infection in vivo. To obtain high-affinity peptides that can be used to block CCR5, CCR5 analogs with high conformational similarity are required. In this study, two recombinant proteins named CCR5 N-Linker-E2 and CCR5 mN-E1-E2 containing the fragments of the CCR5 N-terminal, the first extracellular loop or the second extracellular loop are cloned from a full-length human CCR5 cDNA. The recombinant human CCR5 analogs with self-cleavage activity of the intein Mxe or Ssp in the vector pTwinI were then produced with a high-yield expression and purification system in Escherichia coli. Experiments of extracellular epitope-activity identification (such as immunoprecipitation and indirective/competitive enzyme-linked immunosorbent assay) confirmed the close similarity between the epitope activity of the CCR5 analogs and that of the natural CCR5, suggesting the applicability of the recombinant CCR5 analogs as antagonists of the chemokine ligands. Subsequent screening of high-affinity peptides from the phage random-peptides library acquired nine polypeptides, which could be used as CCR5 peptide antagonists. The CCR5 analogs and affinity peptides elucidated in this paper provide us with a basis for further study of the mechanism of inhibition of HIV-1 infection.

  14. TV Analog Station Transmitters

    Data.gov (United States)

    Department of Homeland Security — This file is an extract from the Consolidated Database System (CDBS) licensed by the Media Bureau. It consists of Analog Television Stations (see Rule Part47 CFR...

  15. Comparative Study on Innovation Incentives for Commercial Open Source Software under Different Licenses

    Directory of Open Access Journals (Sweden)

    Mingqing Xing

    2013-02-01

    Full Text Available This study compares technological innovation incentives for commercial open source software under two typical licenses (the GNU General Public License and the Berkeley Software Distribution License, i.e., GPL and BSD. In the case of private optimum, the incentive towards software features (resp. usability innovation is always higher (resp. lower under BSD than under GPL. Contrast to the private optimum, the social planner expects more investment in software feature under both BSD and GPL, but less (resp. equivalent investment in software usability under BSD (resp. GPL.

  16. 9 CFR 102.3 - License applications.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false License applications. 102.3 Section... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL PRODUCTS § 102.3 License applications. (a) U.S. Veterinary Biologics Establishment License. (1)...

  17. Occupational Licensing

    OpenAIRE

    Morris M. Kleiner

    2000-01-01

    The study of the regulation of occupations has a long and distinguished tradition in economics. In this paper, I present the central arguments and unresolved issues involving the costs and benefits of occupational licensing. The main benefits that are suggested for occupational licensing involve improving quality for those persons receiving the service. In contrast, the costs attributed to this labor market institution are that it restricts the supply of labor to the occupation and thereby dr...

  18. An In Situ Study of Analogical Reasoning in Novice and Experienced Design Engineers

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Christensen, B T

    2009-01-01

    This paper describes a study to understand the use of analogies by design engineers with different levels of experience in an adaptive design domain. Protocol analyses of 12 design engineers have been analyzed to understand the functions and reasoning of the analogies. The protocols are real......-world data from the aerospace industry. The findings indicate a significant difference in both the use of analogies by novices and experienced designers and the reasoning from the analogies. Novices were found to predominantly transfer information related to the geometric properties without explicit...... reference to relevant design issues or to the appropriateness of applying the analogy, whereas experienced designers tended to use analogies for problem solving and problem identification. Experienced designers were found to use the analogy to reason about the function of a component and the predicted...

  19. Contractual Solutions in Electronic Publishing Industry: A Comparative study of License Agreements

    Directory of Open Access Journals (Sweden)

    K.T. Anuradha

    2005-10-01

    Full Text Available Information Technology (IT revolution has brought global change and has impact on electronic publishing industry also. In the digital and networked environment, publishers are concerned about protecting their products from illegal use. Copyright has been proclaimed as an important weapon by the publishers to safeguard their products. In view of the increasing importance that is gained by contract law in electronic publishing, more and more libraries are engaged in signing License Agreements for getting access to all types of electronic information products. It has become imperative on the part of librarians to have knowledge of License agreements and their clauses. The body of the license agreements differs from publisher to publisher and is product dependent too. Since there is a difference between the license agreements of societal publishers and commercial publishers, an attempt is made here to carry out a comparative study of the clauses of the license agreements among commercial publishers at the first level and societal publishers at the second level. It is observed that the licensors’ rights are well protected compared to that of licensees’ rights.

  20. Development of neuropeptide analogs capable of traversing the integument: A case study using diapause hormone analogs in Helicoverpa zea.

    Science.gov (United States)

    Zhang, Qirui; Nachman, Ronald J; Kaczmarek, Krzysztof; Kierus, Krzysztof; Zabrocki, Janusz; Denlinger, David L

    2015-12-01

    Diapause hormone and its analogs terminate pupal diapause in Helicoverpa zea when injected, but if such agents are to be used as effective diapause disruptors it will be essential to develop simple techniques for administering active compounds that can exert their effect by penetrating the insect epidermis. In the current study, we used two molecules previously shown to have high diapause-terminating activity as lead molecules to rationally design and synthesize new amphiphilic compounds with modified hydrophobic components. An assay for diapause termination identified 13 active compounds with EC50's ranging from 0.9 to 46.0 pmol per pupa. Three compounds, Decyl-1963, Dodecyl-1967, and Heptyl-1965, selected from the 13 compounds most active in breaking diapause following injection, also successfully prevented newly-formed pupae from entering diapause when applied topically. These compounds feature straight-chain, aliphatic hydrocarbons from 7 to 12 carbons in length; DH analogs with either a short-chain length of 4 or an aromatic phenethyl group failed to act topically. Compared to a high diapause incidence of 80-90% in controls, diapause incidence in pupae receiving a 10 nmole topical application of Decyl-1963, Dodecyl-1967, or Heptyl-1965 dropped to 30-45%. Decyl-1963 and Dodecyl-1967 also remained effective when topically applied at the 1 nmole level. These results suggest the feasibility of developing DH agonists that can be applied topically and suggest the identity of new lead molecules for development of additional topically-active DH analogs. The ability to penetrate the insect epidermis and/or midgut lining is critical if such agents are to be considered for future use as pest management tools.

  1. Embedding Analogical Reasoning into 5E Learning Model: A Study of the Solar System

    Science.gov (United States)

    Devecioglu-Kaymakci, Yasemin

    2016-01-01

    The purpose of this study was to investigate how the 5E learning model affects learning about the Solar System when an analogical model is utilized in teaching. The data were gathered in an urban middle school 7th grade science course while teaching relevant astronomy topics. The analogical model developed by the researchers was administered to 20…

  2. 9 CFR 102.6 - Conditional licenses.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL...) of this part, issue a conditional U.S. Veterinary Biological Product License to an establishment... available, the Administrator shall either reissue the U.S. Veterinary Biological Product License or allow...

  3. Analogical scaffolding and the learning of abstract ideas in physics: Empirical studies

    Directory of Open Access Journals (Sweden)

    Noah D. Finkelstein

    2007-09-01

    Full Text Available Previously, we proposed a model of student reasoning which combines the roles of representation, analogy, and layering of meaning—analogical scaffolding [Podolefsky and Finkelstein, Phys. Rev. ST Phys. Educ. Res. 3, 010109 (2007]. The present empirical studies build on this model to examine its utility and demonstrate the vital intertwining of representation, analogy, and conceptual learning in physics. In two studies of student reasoning using analogy, we show that representations couple to students’ existing prior knowledge and also lead to the dynamic formation of new knowledge. Students presented with abstract, concrete, or blended (both abstract and concrete representations produced markedly different response patterns. In the first study, using analogies to scaffold understanding of electromagnetic (EM waves, students in the blend group were more likely to reason productively about EM waves than students in the abstract group by as much as a factor of 3 (73% vs 24% correct, p=0.002 . In the second study, examining representation use within one domain (sound waves, the blend group was more likely to reason productively about sound waves than the abstract group by as much as a factor of 2 (48% vs 23% correct, p=0.002 . Using the analogical scaffolding model we examine when and why students succeed and fail to use analogies and interpret representations appropriately.

  4. A comparative study on fluorescent cholesterol analogs as versatile cellular reporters

    DEFF Research Database (Denmark)

    Sezgin, Erdinc; Betul Can, Fatma; Schneider, Falk

    2016-01-01

    Cholesterol is a crucial component of cellular membranes, but knowledge of its intracellular dynamics is scarce. Thus, it is of utmost interest to develop tools for visualization of cholesterol organization and dynamics in cells and tissues. For this purpose, many studies make use of fluorescently......-labeled cholesterol analogs. Unfortunately, the introduction of the label may influence the characteristics of the analog, such as its localization, interaction and trafficking in cells, hence it is important to get knowledge of such bias. In this report, we compared different fluorescent lipid analogs...

  5. A study of the validity of the Korean Nurses' Licensing Examination

    OpenAIRE

    Hyang Yeon Lee; Cho Ja Kim; Sook Ja Lee; Ho Ran Park; In Sook Lee; Hoo Ja Kim; Young Mi Park

    2005-01-01

    This study tested the validity of subjects in the Korean Nurses' Licensing Examination (KNLE). To determine the validity of test items in the KNLE, the items testing each subject in the examination and all of the test items were compared. The homogeneity and proper degree of conceptual diversity of the items in the examination were tested by comparing the frameworks of the test items in the National Council Licensure Examination for Registered Nurses (NCLEX-RN) and the KNLE. The validity...

  6. Study of structure-activity relationship in Aurein 1.2 analogs.

    Science.gov (United States)

    Soufian, Safieh; Hassani, Leila

    2011-07-15

    Two new analogs of Aurein 1.2 antimicrobial peptide were synthesized and the antimicrobial activities were investigated. The results showed that the activity of G1R/F3W analog was higher than the native peptide and the F3W analog. Circular dichroism studies also showed that the secondary structure of the F3W was concentration-dependent, whereas, there was no such relationship seen in the case of G1R/F3W analog. It has been proposed that G1R/F3W activity was based on a single mechanism (snorkeling), while Aurein 1.2 and F3W utilized the snorkeling mechanism at low concentrations (0-0.01 mM) and the carpet mechanism at higher concentrations (0.01-0.1 mM). This study suggests that one pay attention to the concentration of biomolecules in peptide-based drug design.

  7. General and specialized brain correlates for analogical reasoning: A meta-analysis of functional imaging studies.

    Science.gov (United States)

    Hobeika, Lucie; Diard-Detoeuf, Capucine; Garcin, Béatrice; Levy, Richard; Volle, Emmanuelle

    2016-05-01

    Reasoning by analogy allows us to link distinct domains of knowledge and to transfer solutions from one domain to another. Analogical reasoning has been studied using various tasks that have generally required the consideration of the relationships between objects and their integration to infer an analogy schema. However, these tasks varied in terms of the level and the nature of the relationships to consider (e.g., semantic, visuospatial). The aim of this study was to identify the cerebral network involved in analogical reasoning and its specialization based on the domains of information and task specificity. We conducted a coordinate-based meta-analysis of 27 experiments that used analogical reasoning tasks. The left rostrolateral prefrontal cortex was one of the regions most consistently activated across the studies. A comparison between semantic and visuospatial analogy tasks showed both domain-oriented regions in the inferior and middle frontal gyri and a domain-general region, the left rostrolateral prefrontal cortex, which was specialized for analogy tasks. A comparison of visuospatial analogy to matrix problem tasks revealed that these two relational reasoning tasks engage, at least in part, distinct right and left cerebral networks, particularly separate areas within the left rostrolateral prefrontal cortex. These findings highlight several cognitive and cerebral differences between relational reasoning tasks that can allow us to make predictions about the respective roles of distinct brain regions or networks. These results also provide new, testable anatomical hypotheses about reasoning disorders that are induced by brain damage. Hum Brain Mapp 37:1953-1969, 2016. © 2016 Wiley Periodicals, Inc.

  8. The Higgs mechanism and superconductivity: A case study of formal analogies

    Science.gov (United States)

    Fraser, Doreen; Koberinski, Adam

    2016-08-01

    Following the experimental discovery of the Higgs boson, physicists explained the discovery to the public by appealing to analogies with condensed matter physics. The historical root of these analogies is the analogies to models of superconductivity that inspired the introduction of spontaneous symmetry breaking (SSB) into particle physics in the early 1960s. We offer a historical and philosophical analysis of the analogies between the Higgs model of the electroweak (EW) interaction and the Ginsburg-Landau (GL) and Bardeen-Cooper-Schrieffer (BCS) models of superconductivity, respectively. The conclusion of our analysis is that both sets of analogies are purely formal in virtue of the fact that they are accompanied by substantial physical disanalogies. In particular, the formal analogies do not map the temporal, causal, or modal structures of SSB in superconductivity to temporal, causal, or modal structures in the Higgs model. These substantial physical disanalogies mean that analogies to models of superconductivity cannot supply the basis for the physical interpretation of EW SSB; however, an appreciation of the contrast between the physical interpretations of SSB in superconductivity and the Higgs model does help to clarify some foundational issues. Unlike SSB in superconductivity, SSB in the Higgs sector of the Standard Model (without the addition of new physics) is neither a temporal nor a causal process. We discuss the implications for the 'eating' metaphor for mass gain in the Higgs model. Furthermore, the distinction between the phenomenological GL model and the dynamical BCS model does not carry over to EW models, which clarifies the desiderata for the so-called 'dynamical' models of EW SSB (e.g., minimal technicolor). Finally, the development of the Higgs model is an illuminating case study for philosophers of science because it illustrates how purely formal analogies can play a fruitful heuristic role in physics.

  9. Lessons from Natural Analog Studies for Geologic Disposal of High-Level Nuclear Waste (Invited)

    Science.gov (United States)

    Murphy, W. M.

    2009-12-01

    For over fifty years natural analog studies have provided lessons addressing scientific, technical, and social problems concerning geologic disposal of high-level nuclear waste. Idealized concepts for permanent disposal environments evolved from an understanding of the geological, geochemical and hydrological characteristics of analogous rocks including natural salt deposits (as advocated by the US National Academy of Sciences in 1957), ancient cratonic rocks (as investigated at Lac du Bonnet, Canada, Aspö, Sweden, and Vienne, France), and marine sedimentary rock formations (as studied at Mol, Belgium, and Bure, France). Additional multidisciplinary studies have been conducted at natural sites that bear characteristics analogous to potential repository systems, notably at natural uranium (and thorium) deposits including Poços de Caldas, Brazil, Alligator Rivers, Australia, Peña Blanca, Mexico, and Oklo, Gabon. Researchers of natural analogs for geologic disposal have addressed technical uncertainties regarding processes that have transpired over large time and space scales, which are generally inaccessible to laboratory studies. Principal questions for nuclear waste disposal include the geochemical stability and alteration rates of radionuclide bearing minerals and the mechanisms and rates of transport of radionuclides in groundwater. In their most direct applications, natural analogs studies have been devoted to testing specific models for repository performance and the experimental data that support those models. Parameters used in predictive performance assessment modeling have been compared to natural system data, including mineral solubilities, sorption coefficients, diffusion rates, and colloid transport properties. For example, the rate of uraninite oxidation and the natural paragenesis of uranium mineral alteration at Peña Blanca have been compared favorably to results of experimental studies of spent fuel alteration related to the proposed repository

  10. Barrier analogs: Long-term performance issues, preliminary studies, and recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Waugh, W.J. [Rust Geotech, Inc., Grand Junction, CO (United States). Environmental Sciences Lab.; Chatters, J.C.; Last, G.V.; Bjornstad, B.N.; Link, S.O. [Pacific Northwest Lab., Richland, WA (United States); Hunter, C.R. [Cascade Earth Sciences, La Grande, OR (United States)

    1994-02-01

    The US Department of Energy`s Hanford Protective Barrier Development Program is funding studies of natural analogs of the long-term performance of waste site covers. Natural-analog studies examine past environments as evidence for projecting the future performance of engineered structures. The information generated by analog studies is needed to (1) evaluate the designs and results of short term experiments and demonstrations, (2) formulate performance-modeling problems that bound expected changes in waste site environments, and (3) understand emergent system attributes that cannot be evaluated with short-term experiments or computer models. Waste site covers will be part of dynamic environmental systems with attributes that transcend the traits of engineered components. This report discusses results of the previously unreported preliminary studies conducted in 1983 and 1984. These results indicate that analogs could play an important role in predicting the long-term behavior of engineered waste covers. Layered exposures of glacial-flood-deposited gravels mantled with silt or sand that resemble contemporary barrier designs were examined. Bergmounds, another anomaly left by cataclysmic glacial floods, were also examined as analogs of surface gravel.

  11. Anandamide and analogous endocannabinoids: a lipid self-assembly study

    Energy Technology Data Exchange (ETDEWEB)

    Sagnella, Sharon M.; Conn, Charlotte E.; Krodkiewska, Irena; Mulet, Xavier; Drummond, Calum J.

    2014-09-24

    Anandamide, the endogenous agonist of the cannabinoid receptors, has been widely studied for its interesting biological and medicinal properties and is recognized as a highly significant lipid signaling molecule within the nervous system. Few studies have, however, examined the effect of the physical conformation of anandamide on its function. The study presented herein has focused on characterizing the self-assembly behaviour of anandamide and four other endocannabinoid analogues of anandamide, viz., 2-arachidonyl glycerol, arachidonyl dopamine, 2-arachidonyl glycerol ether (noladin ether), and o-arachidonyl ethanolamide (virodhamine). Molecular modeling of the five endocannabinoid lipids indicates that the highly unsaturated arachidonyl chain has a preference for a U or J shaped conformation. Thermal phase studies of the neat amphiphiles showed that a glass transition was observed for all of the endocannabinoids at {approx} -110 C with the exception of anandamide, with a second glass transition occurring for 2-arachidonyl glycerol, 2-arachidonyl glycerol ether, and virodhamine (-86 C, -95 C, -46 C respectively). Both anandamide and arachidonyl dopamine displayed a crystal-isotropic melting point (-4.8 and -20.4 C respectively), while a liquid crystal-isotropic melting transition was seen for 2-arachidonyl glycerol (-40.7 C) and 2-arachidonyl glycerol ether (-71.2 C). No additional transitions were observed for virodhamine. Small angle X-ray scattering and cross polarized optical microscopy studies as a function of temperature indicated that in the presence of excess water, both 2-arachidonyl glycerol and anandamide form co-existing Q{sub II}{sup G} (gyroid) and Q{sub II}{sup D} (diamond) bicontinuous cubic phases from 0 C to 20 C, which are kinetically stable over a period of weeks but may not represent true thermodynamic equilibrium. Similarly, 2-arachidonyl glycerol ether acquired an inverse hexagonal (HII) phase in excess water from 0 C to 40 C, while

  12. Mineralogical studies of lunar meteorites and their lunar analogs

    Science.gov (United States)

    Takeda, H.; Mori, H.; Miyamoto, M.; Ishii, T.

    1985-01-01

    The minerology and textural properties of three lunar meteorites (Yamato 791197, ALH81005, and Yamato 82192) were analyzed and compared with lunar surface rock samples. The chemical composition and textures of pyroxene and the occurrance of glass matrices were specifically addressed. The study of glass in the lunar meteorites suggests that the glass was not produced by a meteorite impact which excavated the mass into orbit towards the Earth. The glass had been devitrified on the lunar surface before the excavation, and new glass was not produced by the last impact.

  13. A study on the application of two different acoustic analogies to experimental PIV data

    NARCIS (Netherlands)

    Koschatzky, V.; Westerweel, J.; Boersma, B.J.

    2011-01-01

    The aim of the present study is to compare two different acoustic analogies applied to time-resolved particle image velocimetry (PIV) data for the prediction of the acoustic far-field generated by the flow over a rectangular cavity. We consider the model problem of sound radiating from an open, two-

  14. Study of $^{13}$Be through isobaric analog resonances in the Maya active target

    CERN Multimedia

    Riisager, K; Orr, N A; Jonson, B N G; Raabe, R; Fynbo, H O U; Nilsson, T

    We propose to perform an experiment with a $^{12}$Be beam and the Maya active target. We intend to study the ground state of $^{13}$Be through the population of its isobaric analog resonance in $^{13}$B. The resonance will be identified detecting its proton- and neutron-decay channels.

  15. The neuromechanism underlying verbal analogical reasoning of metaphorical relations: an event-related potentials study.

    Science.gov (United States)

    Zhao, Ming; Meng, Huishan; Xu, Zhiyuan; Du, Fenglei; Liu, Tao; Li, Yongxin; Chen, Feiyan

    2011-11-24

    Using event-related potentials (ERPs), this study investigated the neuromechanism underlying verbal analogical reasoning of two different metaphorical relations: attributive metaphor and relational metaphor. The analogical reasoning of attributive metaphor (AM-AR) involves a superficial similarity between analogues, while the analogical reasoning of relational metaphor (RM-AR) requires a structural similarity. Subjects were asked to judge whether one word pair was semantically analogous to another word pair. Results showed that the schema induction stage elicited a greater N400 component at the right anterior scalp for the AM-AR and RM-AR tasks, possibly attributable to semantic processing of metaphorical word pairs. The N400 was then followed by a widely distributed P300 and a late negative component (LNC1) at the left anterior scalp. The P300 was possibly related to the formation of a relational category, while the LNC1 was possibly related to the maintenance of a reasoning cue in working memory. The analogy mapping stage elicited broadly distributed N400 and LNC2, which might indicate the presence of semantic retrieval and analogical transfer. In the answer production stage, all conditions elicited the P2 component due to early stimulus encoding. The largest P2 amplitude was in the RM-AR task. The RM-AR elicited a larger LPC than did the AM-AR, even though the baseline correction was taken as a control for the differential P2 effect. The LPC effect might suggest that relational metaphors involved more integration processing than attributive metaphors.

  16. 9 CFR 102.2 - Licenses required.

    Science.gov (United States)

    2010-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR BIOLOGICAL PRODUCTS § 102.2 Licenses required. (a) Every person who prepares biological products subject to the Virus-Serum-Toxin...

  17. Contribution of studies for environmental licensing to the knowledge of Santa Catarina avifauna in southern Brazil

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Guimarães Azevedo

    2006-03-01

    Full Text Available The knowledge generated by studies for environmental licensing, even with reduced field samplings, can contribute to the recording of species of avifauna or actually extends the distribution in places of low knowledge. This study presents data obtained from preliminary reports of impact where the avifauna in seven projects in different ecosystems of Santa Catarina state was diagnosed between January 2001 and January 2004. Sightings had occurred, mainly, by visual or auditory contacts, using binoculars, hand-recorders and field guides. A total of 232 species of birds had been registered, increasing the known distribution by 66 species in different regions of Santa Catarina. The habitat most damaged by entrepreneurial activity was the forest, a factor of concern regarding the conservation of the avifauna that relied upon it. In general, the risk factors associated with the avifauna in Santa Catarina state are environmental degradation, capture of wildlife for breeding in captivity and, hunting for food.

  18. Corruption Risks in Water Licensing. With case studies from Chile and Kazakhstan

    NARCIS (Netherlands)

    Warner, J.F.; Butterworth, J.; Wegerich, K.; Mora Vallejo, A.P.; Martinez, A.; Gouet, C.; Visscher, J.T.

    2009-01-01

    Water resource licensing is increasingly becoming a cornerstone for integrated water resources management (IWRM). Licensing and other allocation mechanisms are important because they underpin who gets access to water and provide a means to manage water fairly, efficiently and sustainably. Water lice

  19. Final report of the AECL/SKB Cigar Lake analog study. AECL research No. AECL-10851

    Energy Technology Data Exchange (ETDEWEB)

    Cramer, J.J.; Smellie, J.A.T. (eds.)

    1994-07-15

    AECL has conducted natural analog studies on the Cigar Lake uranium deposit in northern Saskatchewan since 1984 as part of the Canadian Nuclear Fuel Waste Management Program. This report provides background information and summarizes the results of the study, emphasizing the analog aspects and the implications of modelling activities related to the performance assessment of disposal concepts for nuclear fuel wastes developed in both Canada and Sweden. The study was undertaken to obtain an understanding of the process involved in, and the effects of, steady-state water-rock interaction and trace-element migration in and around the deposit, including paleo-migration processes since the deposit was formed. To achieve these objectives, databases and models were produced to evaluate the equilibrium thermodynamic codes and databases; the role of colloids, organics, and microbes in transport processes for radionuclides; and the stability of UO2 and the influence of radiolysis on UO2 dissolution and radionuclide migration.

  20. A Study of Greek Teachers' Satisfaction with the Implementation of the European Pedagogical ICT License Pilot Course

    Science.gov (United States)

    Mouzakis, Charalambos; Roussakis, Ioannis; Tsagarissianos, George

    2010-01-01

    The survey presented in this study examines Greek teachers' satisfaction with the implementation of the European Pedagogical Information and Communication Technology License (EPICT) pilot course. A total of 51 primary and secondary education teachers participated in the study that followed the pilot course concerning the integration of ICT in the…

  1. Using Analogies in Teaching Physics: A Study on Latvian Teachers' Views and Experience

    Science.gov (United States)

    Jonane, Lolita

    2015-01-01

    The role of analogies as tools for teaching difficult science concepts has been widely discussed in science education. The application of analogies in the context of sustainable education involves richer potential. The purposeful use of appropriate analogies can facilitate analogical thinking and transfer skills, as well as develop abilities which…

  2. “The balancing act”— Licensed practical nurse experiences of falls and fall prevention: a qualitative study

    Directory of Open Access Journals (Sweden)

    Häggqvist Beatrice

    2012-10-01

    Full Text Available Abstract Background Falls are common in old age and may have serious consequences. There are many strategies to predict and prevent falls from occurring in long-term care and hospitals. The aim of this study was to describe licensed practical nurse experiences of predicting and preventing further falls when working with patients who had experienced a fall-related fracture. Licensed practical nurses are the main caretakers that work most closely with the patients. Methods A qualitative study of focus groups interviews and field observations was done. 15 licensed practical nurses from a rehabilitation ward and an acute ward in a hospital in northern Sweden were interviewed. Content was analyzed using qualitative content analysis. Results The result of the licensed practical nurse thoughts and experiences about risk of falling and fall prevention work is represented in one theme, “the balancing act”. The theme includes three categories: “the right to decide”, “the constant watch”, and “the ongoing negotiation” as well as nine subcategories. The analysis showed similarities and differences between rehabilitation and acute wards. At both wards it was a core strategy in the licensed practical nurse work to always be ready and to pay attention to patients’ appearance and behavior. At the rehabilitation ward, it was an explicit working task to judge the patients’ risk of falling and to be active to prevent falls. At the acute ward, the words “risk of falling” were not used and fall prevention were not discussed; instead the licensed practical nurses used for example “dizzy and pale”. The results also indicated differences in components that facilitate workplace learning and knowledge transfer. Conclusions Differences between the wards are most probably rooted in organizational differences. When it is expected by the leadership, licensed practical nurses can express patient risk of falling, share their observations with others

  3. A Case Study Analysing the Process of Analogy-Based Learning in a Teaching Unit about Simple Electric Circuits

    Science.gov (United States)

    Paatz, Roland; Ryder, James; Schwedes, Hannelore; Scott, Philip

    2004-01-01

    The purpose of this case study is to analyse the learning processes of a 16-year-old student as she learns about simple electric circuits in response to an analogy-based teaching sequence. Analogical thinking processes are modelled by a sequence of four steps according to Gentner's structure mapping theory (activate base domain, postulate local…

  4. U-Series Transport Studies at the Pena Blanca, Mexico Natural Analog Site

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Simmons; M. T. Murrell

    2001-05-31

    Natural analogs provide a line of evidence that supports the understanding of how natural and engineered processes would occur over long time frames and large spatial scales at a potential nuclear waste repository at Yucca Mountain, Nevada. Studies of U-series disequilibria within and around uranium deposits can provide valuable information on the timing of actinide mobility and hence the stability of a potential repository over geologic time scales. The Nopal I uranium deposit at Pena Blanca, Mexico, is situated in unsaturated tuff that is similar in composition to the Topopah Spring Tuff of Yucca Mountain and closely matches other evaluation criteria for suitable natural analogs. By modeling the observed radioactive isotope disequilibria at Nopal I, we can estimate the rates of sorption-desorption and dissolution-precipitation of the radionuclides over time. Such information is vital to the testing or validation of performance assessment models for geologic nuclear waste disposal.

  5. A study of the validity of the Korean Nurses' Licensing Examination

    Directory of Open Access Journals (Sweden)

    Hyang Yeon Lee

    2005-06-01

    Full Text Available This study tested the validity of subjects in the Korean Nurses' Licensing Examination (KNLE. To determine the validity of test items in the KNLE, the items testing each subject in the examination and all of the test items were compared. The homogeneity and proper degree of conceptual diversity of the items in the examination were tested by comparing the frameworks of the test items in the National Council Licensure Examination for Registered Nurses (NCLEX-RN and the KNLE. The validity of the KNLE was determined by examining the correlations between the scores that the same individuals obtained on the KNLE in 2002 and their college marks. This study showed that basic core items appeared repeatedly in the KNLE, and items in the examination were selected according to the importance of each subject examined. Therefore, a new test system based on united subjects should be considered to solve these problems. Further studies are needed to develop a framework for classifying the test items that should be included as united subjects through considering the job description and goals of study of nurses.

  6. Nursing: Licensed Practical and Licensed Vocational Nurses

    Science.gov (United States)

    ... Projected Employment, 2024 Change, 2014-24 Employment by Industry Percent Numeric SOURCE: U.S. Bureau of Labor Statistics, Employment Projections program Licensed practical and licensed vocational ...

  7. Design, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit.

    Science.gov (United States)

    Wu, Chunjiang; Wang, Min; Tang, Qidong; Luo, Rong; Chen, Le; Zheng, Pengwu; Zhu, Wufu

    2015-10-23

    Two series of novel sorafenib analogs containing a sulfonylurea unit were synthesized and their chemical structures were confirmed by ¹H-NMR, ¹³C-NMR, MS spectrum and elemental analysis. The synthesized compounds were evaluated for the cytotoxicity against A549, Hela, MCF-7, and PC-3 cancer cell lines. Some of the compounds showed moderate cytotoxic activity, especially compounds 1-(2,4-difluorophenylsulfonyl)-3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea (6c) and 1-(4-bromophenylsulfonyl)-3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea (6f) with the IC50 values against four cancer cell lines ranging from 16.54±1.22 to 63.92±1.81 μM, respectively. Inhibitory rates against vascular endothelial growth factor receptor-2 (VEGFR2/KDR) kinase at 10 μM of target compounds were further carried out in this paper in order to investigate the target of these compounds. Structure-activity relationships (SARs) and docking studies indicated that the sulfonylurea unit was important to these kinds of compounds. None of the substitutions in the phenoxy group and small halogen atoms such as 2,4-difluoro substitution of the aryl group contributed to the activity. The results suggested that sulfonylurea sorafenib analogs are worthy of further study.

  8. Using Student-Generated Analogies to Investigate Conceptions of Energy: A multidisciplinary study

    Science.gov (United States)

    Anderman Lancor, Rachael

    2014-01-01

    The concept of energy is widely employed in introductory science courses. However, the term energy is defined and utilized in different ways depending on the context, even within a given discipline. Through the lens of metaphor theory, these various definitions of energy are seen as metaphors that highlight and obscure characteristics of energy. Working under this framework, undergraduate students in introductory biology, chemistry, and physics courses were asked to write analogies that reflect their understanding of the role of energy in the context of ecosystems (n = 49), chemical reactions (n = 36), mechanical systems (n = 65), and electrical circuits (n = 44). These analogies were analyzed qualitatively using metaphor theory to gain understanding of how students conceptualize energy in these different contexts. The results of this study indicate that students use seven different conceptual metaphors to explain the role of energy in various scientific contexts: energy as a substance that can be accounted for, energy as a substance that can flow, can change forms, can be carried, can be lost, can be an ingredient or a product, and energy as a process or interaction. This result gives teachers a framework to use in evaluating student ideas about energy.

  9. A Post Licensing Study of Community Effects at Two Operating Nuclear Power Plants. Final Report.

    Science.gov (United States)

    Purdy, Bruce J.; And Others

    In an effort to identify and assess the social, economic, and political effects of nuclear power plant construction and operation upon two host communities (Plymouth, Massachusetts and Waterford, Connecticut), a post-licensing review revealed that the primary impact of the nuclear power plants in both communities was an increase in the property…

  10. Bioprinting of Micro-Organ Tissue Analog for Drug Metabolism Study

    Science.gov (United States)

    Sun, Wei

    An evolving application of tissue engineering is to develop in vitro 3D cell/tissue models for drug screening and pharmacological study. In order to test in space, these in vitro models are mostly manufactured through micro-fabrication techniques and incorporate living cells with MEMS or microfluidic devices. These cell-integrated microfluidic devices, or referred as microorgans, are effective in furnishing reliable and inexpensive drug metabolism and toxicity studies [1-3]. This paper will present an on-going research collaborated between Drexel University and NASA JSC Radiation Physics Laboratory for applying a direct cell printing technique to freeform fabrication of 3D liver tissue analog in drug metabolism study. The paper will discuss modeling, design, and solid freeform fabrication of micro-fluidic flow patterns and bioprinting of 3D micro-liver chamber that biomimics liver physiological microenvironment for enhanced drug metabolization. Technical details to address bioprinting of 3D liver tissue analog, integration with a microfluidic device, and basic drug metabolism study for NASA's interests will presented. 1. Holtorf H. Leslie J. Chang R, Nam J, Culbertson C, Sun W, Gonda S, "Development of a Three-Dimensional Tissue-on-a-Chip Micro-Organ Device for Pharmacokinetic Analysis", the 47th Annual Meeting of the American Society for Cell Biology, Washington, DC, December 1-5, 2007. 2. Chang, R., Nam, J., Culbertson C., Holtorf, H., Jeevarajan, A., Gonda, S. and Sun, W., "Bio-printing and Modeling of Flow Patterns for Cell Encapsulated 3D Liver Chambers For Pharmacokinetic Study", TERMIS North America 2007 Conference and Exposition, Westin Harbour Castle, Toronto, Canada, June 13-16, 2007. 3.Starly, B., Chang, R., Sun, W., Culbertson, C., Holtorf, H. and Gonda, S., "Bioprinted Tissue-on-chip Application for Pharmacokinetic Studies", Proceedings of World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, PA, USA, April 24-27, 2006.

  11. Analog computing

    CERN Document Server

    Ulmann, Bernd

    2013-01-01

    This book is a comprehensive introduction to analog computing. As most textbooks about this powerful computing paradigm date back to the 1960s and 1970s, it fills a void and forges a bridge from the early days of analog computing to future applications. The idea of analog computing is not new. In fact, this computing paradigm is nearly forgotten, although it offers a path to both high-speed and low-power computing, which are in even more demand now than they were back in the heyday of electronic analog computers.

  12. Bed Rest is an Analog to Study the Physiological Changes of Spaceflight and to Evaluate Countermeasures

    Science.gov (United States)

    Pfannenstiel, P.; Ottenbacher, M.; Inniss, A.; Ware, D.; Anderson, K.; Stranges, S.; Keith, K.; Cromwell, R.; Neigut. J.; Powell, D.

    2012-01-01

    The UTMB/NASA Flight Analog Research Unit is an inpatient unit with a bionutrition kitchen and unique testing areas for studying subjects subjected to 6 degree head-down complete bed rest for prolonged periods as an analog for zero gravity. Bed rest allows study of physiological changes and performance of functional tasks representative of critical interplanetary mission operations and measures of the efficacy of countermeasures designed to protect against the resulting deleterious effects. METHODS/STUDY POPULATION: Subjects are healthy adults 24-55 years old; 60 75 in tall; body mass index 18.5-30; and bone mineral density normal by DXA scan. Over 100 subjects have been studied in 7 campaigns since 2004. The iRAT countermeasure combines high intensity interval aerobic exercises on alternating days with continuous aerobic exercise. Resistance exercise is performed 3 days per week. Subjects are tested on an integrated suite of functional and interdisciplinary physiological tests before and after 70 days of total bed rest. RESULTS/ANTICIPATED RESULTS: It is anticipated that post-bed rest functional performance will be predicted by a weighted combination of sensorimotor, cardiovascular and muscle physiological factors. Control subjects who do not participate in the exercise countermeasure will have significantly greater decreases in these parameters. DISCUSSION/SIGNIFICANCE OF IMPACT: Astronauts experience alterations in multiple physiological systems due to exposure to the microgravity, leading to disruption in the ability to perform functional tasks after reintroduction to a gravitational environment. Current flight exercise countermeasures are not fully protective of cardiovascular, muscle and bone health. There is a need to refine and optimize countermeasures to mitigate health risks associated with long-term space missions.

  13. Neutron-skin thickness from the study of the anti-analog giant dipole resonance

    NARCIS (Netherlands)

    Krasznahorkay, A.; Stuhl, L.; Csatlós, M.; Algora, A.; Gulyás, J.; Timár, J.; Paar, N.; Vretenar, D.; Boretzky, K.; Heil, M.; Litvinov, Yu A.; Rossi, D.; Scheidenberger, C.; Simon, H.; Weick, H.; Bracco, A.; Brambilla, S.; Blasi, N.; Camera, F.; Giaz, A.; Million, B.; Pellegri, L.; Riboldi, S.; Wieland, O.; Altstadt, S.; Fonseca, M.; Glorius, J.; Göbel, K.; Heftrich, T.; Koloczek, A.; Kräckmann, S.; Langer, C.; Plag, R.; Pohl, M.; Rastrepina, G.; Reifarth, R.; Schmidt, S.; Sonnabend, K.; Weigand, M.; Harakeh, M. N.; Kalantar-Nayestanaki, N.; Rigollet, C.; Bagchi, S.; Najafi, M. A.; Aumann, T.; Atar, L.; Heine, M.; Holl, M.; Movsesyan, A.; Schrock, P.; Volkov, V.; Wamers, F.; Fiori, E.; Löher, B.; Marganiec, J.; Savran, D.; Johansson, H. T.; Fernández, P. Diaz; Garg, U.; Balabanski, D. L.

    2012-01-01

    The gamma-decay of the anti-analog of the giant dipole resonance (AGDR) has been measured to the isobaric analog state excited in the p(124Sn,n) reaction at a beam energy of 600 MeV/nucleon. The energy of the transition was also calculated with state-of-the-art self-consistent random-phase approxima

  14. 9 CFR 102.1 - Licenses issued by the Administrator.

    Science.gov (United States)

    2010-01-01

    ... OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR... biological products under the Virus-Serum-Toxin Act shall hold an unexpired and unrevoked U.S. Veterinary... CFR parts 103 or 106 of this subchapter....

  15. Is it time for studying real-life debiasing? Evaluation of the effectiveness of an analogical intervention technique

    Directory of Open Access Journals (Sweden)

    Balazs eAczel

    2015-08-01

    Full Text Available The aim of this study was to initiate the exploration of debiasing methods applicable in real-life settings for achieving lasting improvement in decision-making competence regarding multiple decision biases. Here, we tested the potentials of the analogical encoding method for decision debiasing. The advantage of this method is that it can foster the transfer from learning abstract principles to improving behavioral performance. For the purpose of the study, we devised an analogical debiasing technique for ten biases (covariation detection, insensitivity to sample size, base rate neglect, regression to the mean, outcome bias, sunk cost fallacy, framing effect, anchoring bias, overconfidence bias, planning fallacy and assessed the susceptibility of the participants (N = 154 to these biases before and four weeks after the training. We also compared the effect of the analogical training to the effect of an ‘awareness training’ and a ‘no-training’ control group. Results suggested improved performance of the analogical training group only on tasks where the violations of statistical principles are measured. The interpretation of these findings require further investigation, yet it is possible that analogical training may be the most effective in the case of learning abstract concepts, such as statistical principles, which are otherwise difficult to master. The study encourages a systematic research of debiasing trainings and the development of intervention assessment methods to measure the endurance of behavior change in decision debiasing.

  16. Understanding Licensing Behavior

    DEFF Research Database (Denmark)

    Cabaleiro, Goretti; Moreira, Solon; Reichstein, Toke

    The potential for rent dissipation has been argued to be the main cause of firms? licensing out behavior being stifled.However, this aspect has been scarcely studied empirically. We draw on rent dissipation arguments, and hypothesize that firms suffering from the not-invented-here (NIH) syndrome...

  17. Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies.

    Science.gov (United States)

    Taha, Muhammad; Ismail, Nor Hadiani; Imran, Syahrul; Wadood, Abdul; Rahim, Fazal; Khan, Khalid Muhammad; Riaz, Muhammad

    2016-06-01

    Benzothiazole analogs (1-20) have been synthesized, characterized by EI-MS and (1)H NMR, and evaluated for urease inhibition activity. All compounds showed excellent urease inhibitory potential varying from 1.4±0.10 to 34.43±2.10μM when compared with standard thiourea (IC50 19.46±1.20μM). Among the series seventeen (17) analogs 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, and 18 showed outstanding urease inhibitory potential. Analogs 15 and 19 also showed good urease inhibition activity. When we compare the activity of N-phenylthiourea 20 with all substituted phenyl derivatives (1-18) we found that compound 15 showed less activity than compound 20 having 3-methoxy substituent. The binding interactions of these active analogs were confirmed through molecular docking.

  18. Studies of chaos and thermal noise in a driven Josephson junction using an electronic analog

    Energy Technology Data Exchange (ETDEWEB)

    Pegrum, C.M.; Gurney, W.S.C.; Nisbet, R.M.

    1989-03-01

    Using an electronic analog of a resistively shunted driven Josephson junction, the authors have demonstrated a number of effects, including the appearance of a devil's staircase in the current-voltage characteristic, the onset of chaos, and the effect of noise on these phenomena. The authors stress that the analog is simple, but models the junction behavior with a high degree of accuracy and detail.

  19. Molecular simulation of N-acetylneuraminic acid analogs and molecular dynamics studies of cholera toxin-Neu5Gc complex.

    Science.gov (United States)

    Blessy, J Jino; Sharmila, D Jeya Sundara

    2015-01-01

    Cholera toxin (CT) is an AB5 protein complex secreted by the pathogen Vibrio cholera, which is responsible for cholera infection. N-acetylneuraminic acid (NeuNAc) is a derivative of neuraminic acid with nine-carbon backbone. NeuNAc is distributed on the cell surface mainly located in the terminal components of glycoconjugates, and also plays an important role in cell-cell interaction. In our current study, molecular docking and molecular dynamic (MD) simulations were implemented to identify the potent NeuNAc analogs with high-inhibitory activity against CT protein. Thirty-four NeuNAc analogs, modified in different positions C-1/C-2/C-4/C-5/C-7/C-8/C-9, were modeled and docked against the active site of CT protein. Among the 34 NeuNAc analogs, the analog Neu5Gc shows the least extra precision glide score of -9.52 and glide energy of -44.71 kcal/mol. NeuNAc analogs block the CT active site residues HIS:13, ASN:90, LYS:91, GLN:56, GLN:61, and TRP:88 through intermolecular hydrogen bonding. The MD simulation for CT-Neu5Gc docking complex was performed using Desmond. MD simulation of CT-Neu5Gc complex reveals the stable nature of docking interaction.

  20. Hole Burning Imaging Studies of Cancerous and Analogous Normal Ovarian Tissues Utilizing Organelle Specific Dyes

    Energy Technology Data Exchange (ETDEWEB)

    Matsuzaki, Satoshi [Iowa State Univ., Ames, IA (United States)

    2004-01-01

    Presented in this dissertation is the successful demonstration that nonphotochemical hole burning (NPWB) imaging can be used to study in vitro tissue cellular systems for discerning differences in cellular ultrastructures due to cancer development. This has been accomplished with the surgically removed cancerous ovarian and analogous normal peritoneal tissues from the same patient and the application of a fluorescent mitochondrion specific dye, Molecular Probe MitoFluor Far Red 680 (MF680), commonly known as rhodamine 800, that has been proven to exhibit efficient NPHB. From the results presented in Chapters 4 and 5 , and Appendix B, the following conclusions were made: (1) fluorescence excitation spectra of MF680 and confocal microscopy images of thin sliced tissues incubated with MF680 confirm the site-specificity of the probe molecules in the cellular systems. (2) Tunneling parameters, {lambda}{sub 0} and σΛ, as well as the standard hole burning parameters (namely, γ and S), have been determined for the tissue samples by hole growth kinetics (HGK) analyses. Unlike the preliminary cultured cell studies, these parameters have not shown the ability to distinguish tissue cellular matrices surrounding the chromophores. (3) Effects of an external electric (Stark) field on the nonphotochemical holes have been used to determine the changes in permanent dipole moment (fΔμ) for MF680 in tissue samples when burn laser polarization is parallel to the Stark field. Differences are detected between fΔμs in the two tissue samples, with the cancerous tissue exhibiting a more pronounced change (1.35-fold increase) in permanent dipole moment change relative to the normal analogs. It is speculated that the difference may be related to differences in mitochondrial membrane potentials in these tissue samples. (4) In the HGK mode, hole burning imaging (HBI) of cells adhered to coverslips and cooled to liquid helium temperatures in the complete absence of

  1. Hole Burning Imaging Studies of Cancerous and Analogous Normal Ovarian Tissues Utilizing Organelle Specific Dyes

    Energy Technology Data Exchange (ETDEWEB)

    Satoshi Matsuzaki

    2004-12-19

    Presented in this dissertation is the successful demonstration that nonphotochemical hole burning (NPWB) imaging can be used to study in vitro tissue cellular systems for discerning differences in cellular ultrastructures due to cancer development. This has been accomplished with the surgically removed cancerous ovarian and analogous normal peritoneal tissues from the same patient and the application of a fluorescent mitochondrion specific dye, Molecular Probe MitoFluor Far Red 680 (MF680), commonly known as rhodamine 800, that has been proven to exhibit efficient NPHB. From the results presented in Chapters 4 and 5 , and Appendix B, the following conclusions were made: (1) fluorescence excitation spectra of MF680 and confocal microscopy images of thin sliced tissues incubated with MF680 confirm the site-specificity of the probe molecules in the cellular systems. (2) Tunneling parameters, {lambda}{sub 0} and {sigma}{sub {lambda}}, as well as the standard hole burning parameters (namely, {gamma} and S), have been determined for the tissue samples by hole growth kinetics (HGK) analyses. Unlike the preliminary cultured cell studies, these parameters have not shown the ability to distinguish tissue cellular matrices surrounding the chromophores. (3) Effects of an external electric (Stark) field on the nonphotochemical holes have been used to determine the changes in permanent dipole moment (f{Delta}{mu}) for MF680 in tissue samples when burn laser polarization is parallel to the Stark field. Differences are detected between f{Delta}{mu}s in the two tissue samples, with the cancerous tissue exhibiting a more pronounced change (1.35-fold increase) in permanent dipole moment change relative to the normal analogs. It is speculated that the difference may be related to differences in mitochondrial membrane potentials in these tissue samples. (4) In the HGK mode, hole burning imaging (HBI) of cells adhered to coverslips and cooled to liquid helium temperatures in the

  2. 2015 Business Licenses

    Data.gov (United States)

    City of Jackson, Mississippi — This data displays all business license information for the year of 2015. This information details license classifications and status. This information will updated...

  3. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  4. Investigating reinforcer magnitude and reinforcer delay: a contingency management analog study.

    Science.gov (United States)

    Packer, Robert R; Howell, Donelle N; McPherson, Sterling; Roll, John M

    2012-08-01

    The influence of reinforcer magnitude and reinforcer delay on smoking abstinence was studied using an analog model of contingency management. Participants (N = 103, 74% men) visited our laboratory 3 times daily for 5 days and received money for providing a breath sample that indicated smoking abstinence (carbon monoxide level ≤6 parts per million). Using a factorial design, we assigned participants randomly to 1 of 4 groups that could earn a total of either $207.50 (high-magnitude condition) or $70.00 (low-magnitude condition), and received earnings either at each visit (no-delay condition) or in a single lump sum 1 week following the study (delay condition). High-magnitude reinforcement, regardless of delay, was associated with higher rates of abstinence than was low-magnitude reinforcement. High magnitude of reinforcement provided immediately but in incremental amounts was associated with longer intervals to relapse during treatment in comparison with high-magnitude reinforcement provided in a single lump sum after a delay. Low rates of responding in the low-magnitude conditions made interpretation of the impact of delay in those conditions difficult. These findings further demonstrate that high magnitude of reinforcement results in better outcomes than does low magnitude of reinforcement, and that a delay to reinforcement can be detrimental-even when a high magnitude of reinforcement is provided.

  5. Stereoselective synthesis of an iodinated resveratrol analog: Preliminary bioevaluation studies of the radioiodinated species

    Energy Technology Data Exchange (ETDEWEB)

    Dhyani, Manish V.; Kameswaran, Mythili; Korde, Aruna G.; Pandey, Usha [Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Chattopadhyay, Subrata [Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Banerjee, Sharmila, E-mail: sharmila@barc.gov.i [Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2011-07-15

    Stereoselective synthesis of an E-hydroxystilbene has been carried out using the McMurry reaction. Synthesis of a monoiodinated hydroxystilbene has been carried out by a McMurry cross-coupling reaction. For the purpose of biological evaluation, the facile electrophilic substitution route has been attempted to radioiodinate it with {sup 125}I. The HPLC pattern of the radioiodinated hydroxystilbene, which could be obtained in >90% radiochemical purity, was found to be identical to that of its non-radioactive analog that has been independently prepared using the McMurry cross-coupling route. In vitro cell uptake studies were carried out in breast cancer cells MCF7, overexpressing estrogen receptors. In vivo biodistribution studies in female Swiss mice show a uterine uptake of 0.85{+-}0.4% ID/g at 3 h.p.i. with a uterus to muscle ratio of 2.83. Uptake in the thyroid was insignificant indicating good in vivo stability of the radioiodinated hydroxystilbene.

  6. Combined Kinetic Studies and Computational Analysis on Kojic Acid Analogs as Tyrosinase Inhibitors

    Directory of Open Access Journals (Sweden)

    Carlyle Ribeiro Lima

    2014-07-01

    Full Text Available Tyrosinase is a key enzyme in melanin synthesis and widely distributed in plants and animals tissues. In mammals, this enzyme is related to pigment production, involved in wound healing, primary immune response and it can also contribute to catecholamines synthesis in the brain. Consequently, tyrosinase enzyme represents an attractive and selective target in the field of the medicine, cosmetics and bio-insecticides. In this paper, experimental kinetics and computational analysis were used to study the inhibition of tyrosinase by analogous of Kojic acid. The main interactions occurring between inhibitors-tyrosinase complexes and the influence of divalent cation (Cu2+ in enzymatic inhibition were investigated by using molecular docking, molecular dynamic simulations and electrostatic binding free energy by using the Linear Interaction Energy (LIE method. The results showed that the electrostatic binding free energy are correlated with values of constant inhibition (r2 = 0.97.Thus, the model obtained here could contribute to future studies of this important system and, therefore, eventually facilitate development of tyrosinase inhibitors.

  7. Femtosecond Heterodyne Transient Grating Spectroscopic Studies of Intramolecular Charge Transfer Character of Peridinin and Peridinin Analogs

    Science.gov (United States)

    Bishop, Michael; Khosravi, Soroush; Obaid, Razib; Whitelock, Hope; Carroll, Ann Marie; Lafountain, Amy; Frank, Harry; Beck, Warren; Gibson, George; Berrah, Nora

    2016-05-01

    The peridinin chlorophyll-a protein is a light harvesting complex found in several species of dinoflagellates. Peridinin absorbs strongly in the mid-visible spectral region and, despite the lack of a strong permanent dipole moment in its lowest energy excited state, is able to transfer excitation energy quickly and efficiently to chlorophyll-a. It is believed that the high efficiency arises from the development of intramolecular charge-transfer (ICT) character upon photoexcitation. Recently, heterodyne transient grating spectroscopy has been used to study the ultrafast (<50 fs) dynamics of β carotene and peridinin. The studies show evidence for a structurally displaced intermediate in both cases and strong ICT character in the case of peridinin, but up to now the work has not provided appropriate control experiments. The present experiments examine peridinin and two peridinin analogs, S1-peridinin and S2-peridinin. S1-peridinin is reported to have greatly diminished ICT character, and S2-peridinin is reported to have little-or-no ICT character. Heterodyne transient grating data will be presented and provide a more unambiguous characterization spectral and kinetic properties associated with the peridinin ICT state. Funded by the DoE-BES, Grant No. DE-SC0012376.

  8. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs.

    Science.gov (United States)

    Taha, Muhammad; Ismail, Nor Hadiani; Imran, Syahrul; Rahim, Fazal; Wadood, Abdul; Khan, Huma; Ullah, Hayat; Salar, Uzma; Khan, Khalid Mohammed

    2016-10-01

    Hybrid bisindole-thiosemicarbazides analogs (1-18) were synthesized and screened for β-glucuronidase activity. All compounds showed varied degree of β-glucuronidase inhibitory potential when compared with standard d-saccharic acid 1,4-lactone (IC50=48.4±1.25μM). Compounds 4, 7, 9, 6, 5, 12, 17 and 18 showed exceptional β-glucuronidase inhibition with IC50 values ranging from 0.1 to 5.7μM. Compounds 1, 3, 8, 16, 13, 2 and 14 also showed better activities than standard with IC50 values ranging from 7.12 to 15.0μM. The remaining compounds 10, 11, and 15 showed good inhibitory potential with IC50 values 33.2±0.75, 21.4±0.30 and 28.12±0.25μM respectively. Molecular docking studies were carried out to confirm the binding interaction of the compounds.

  9. Analogous Study of the Linguistic Knowledge between Monolingual and Bilingual Students in the Minority Region of Northwestern China

    Science.gov (United States)

    He, Hao

    2008-01-01

    Minority students' English learning is a special and an indispensable component of English education system in China. This article studies students' linguistic knowledge that live in Northwestern China--Gan Nan Autonomy State of Gan Su Province with majority population of Tibetan, mixed with Chinese and some Muslim. An analogous analysis is…

  10. 3D-QSAR study of 20 (S)-camptothecin analogs

    Institute of Scientific and Technical Information of China (English)

    Ai-jun LU; Zhen-shan ZHANG; Ming-yue ZHENG; Han-jun ZOU; Xiao-min LUO; Hua-liang JIANG

    2007-01-01

    Aim: To build up a quantitative structure-activity relationship (QSAR) model of20 (S)-camptothecin (CPT) analogs for the prediction of the activity of new CPT analogs for drug design. Methods: A training set of 43 structurally diverse CPT analogs which were inhibitors of topoisomerase Ⅰ were used to construct a quan-titative structure-activity relationship model with a comparative molecular field analysis (CoMFA). The QSAR model was optimized using partial least squares(PLS) analysis. A test set of 10 compounds was evaluated using the model. Results: The CoMFA model was constructed successfully, and a good cross-validated correlation was obtained in which q2 was 0.495. Then, the analysis of the non-cross-validated PLS model in which r2 was 0.935 was built and permitted demonstrations of high predictability for the activities of the 10 CPT analogs in the test set selected in random. Conclusion: The CoMFA model indicated that bulky negative-charged group at position 9, 10 and 11 of CPT would increase activity, but excessively increasing bulky group at position 10 is adverse to inhibi-tory activity; substituents that occupy position 7 with the bulky positive group will enhance the inhibitive activity. The model can be used to design new CPT analogs and understand the mechanism of action.

  11. Analog earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, R.B. [Center for Nuclear Waste Regulatory Analyses, San Antonio, TX (United States)

    1995-09-01

    Analogs are used to understand complex or poorly understood phenomena for which little data may be available at the actual repository site. Earthquakes are complex phenomena, and they can have a large number of effects on the natural system, as well as on engineered structures. Instrumental data close to the source of large earthquakes are rarely obtained. The rare events for which measurements are available may be used, with modfications, as analogs for potential large earthquakes at sites where no earthquake data are available. In the following, several examples of nuclear reactor and liquified natural gas facility siting are discussed. A potential use of analog earthquakes is proposed for a high-level nuclear waste (HLW) repository.

  12. Neutron-skin thickness from the study of the anti-analog giant dipole resonance

    OpenAIRE

    2012-01-01

    The gamma-decay of the anti-analog of the giant dipole resonance (AGDR) has been measured to the isobaric analog state excited in the p(124Sn,n) reaction at a beam energy of 600 MeV/nucleon. The energy of the transition was also calculated with state-of-the-art self-consistent random-phase approximation (RPA) and turned out to be very sensitive to the neutron-skin thickness (\\DeltaR_(pn)). By comparing the theoretical results with the measured one, the \\DeltaR_(pn) value for 124Sn was deduced...

  13. Design and Synthesis of an Inositol Phosphate Analog Based on Computational Docking Studies.

    Science.gov (United States)

    Peng, Zhenghong; Maxwell, David; Sun, Duoli; Ying, Yunming; Schuber, Paul T; Bhanu Prasad, Basvoju A; Gelovani, Juri; Yung, Wai-Kwan Alfred; Bornmann, William G

    2014-01-28

    A virtual library of 54 inositol analog mimics of In(1,4,5)P3 has been docked, scored, and ranked within the binding site of human inositol 1,4,5-trisphosphate 3-kinase A (IP3-3KA). Chemical synthesis of the best scoring structure that also met distance criteria for 3'-OH to -P in Phosphate has been attempted along with the synthesis of (1S,2R,3S,4S)-3-fluoro-2,4-dihydroxycyclohexanecarboxylic acid as an inositol analog, useful for non-invasive visualization and quantitation of IP3-3KA enzymatic activity.

  14. Studies on the Synthesis of a Natural Product-Piceatannol and its Analogs

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Piceatannol, (E)-3, 3(, 4, 5(-tetrahydroxy stilbene, a natural polyhydroxy stilbene, possesses many biological activities, its synthesis has been reported. We designed another route of its synthesis, which can be controlled more easily. The synthetic product was characterized by elemental analysis, IR, MS and 1H-NMR. Its analogs were synthesized by the similar method.

  15. Study of the interaction between bovine hemoglobin and analogs of biphenyldicarboxylate by spectrofluorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ruiyong, E-mail: wangry@zzu.edu.cn [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China); Yin, Yujing [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China); Wang, Ruiqiang [The First Afficiated Hospiatal of Zhengzhou University, Zhengzhou 450052 (China); Xie, Yuanzhe; Ge, Baoyu; Li, Zhigang; Li, Zhen; Shi, Jie [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China); Chang, Junbiao, E-mail: changjunbiao@zzu.edu.cn [Department of Chemistry, Zhengzhou University, Zhengzhou 450001 (China)

    2013-12-15

    The interaction between bovine hemoglobin and analogs of Biphenyldicarboxylate was investigated by fluorescence, synchronous fluorescence, ultraviolet–vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra at pH 7.40. The quenching mechanism and binding constants were determined by the quenching of bovine hemoglobin fluorescence in presence of analogs. Results showed that the nature of the quenching was of static type. Both the van der Waals and hydrogen bonding played a major role in stabilizing the complex. The distance between donor and acceptors was obtained to be 2.11–2.25 nm according to Förster's theory. The influence of analogs on the conformation of bovine hemoglobin was investigated. -- Highlights: • The interactions between bovine hemoglobin and analogs of DDB have been investigated. • Results reveal that DDB has the strongest affinity for hemoglobin among four compounds. • The van der Waals and hydrogen bonding play major role in the binding process. • The influence of molecular structure on the binding aspects has been investigated.

  16. Overcoming Junior High School Students' Misconceptions About Microscopic Views of Phase Change: A Study of an Analogy Activity

    Science.gov (United States)

    Tsai, Chin-Chung

    1999-03-01

    This study was conducted to examine the effectiveness of an analogy activity, which was designed to overcome junior high students' misconceptions about the microscopic views of phase change. Eighty Taiwanese 8 th graders were randomly assigned to either a control group or an experimental group. For the control group, the subjects were instructed through traditional teaching whereas for the experimental group, an analogy activity was conducted on students. This specific analogy activity was presented in the form of role-playing in which students acted as particles and worked together to perform the conditions of phase changes. Through analyzing these students' drawings of the atom arrangements for the three states of some substances, it was found that the students of experimental group, though in many cases, did not perform statistically better than did those of control group in an immediate posttest. The comparisons of a delay test between these two groups indicated that the analogy activity had clearly positive impacts on students' conceptual change on these scientific concepts in terms of long-term observations.

  17. Implementation study of an analog spiking neural network for assisting cardiac delay prediction in a cardiac resynchronization therapy device.

    Science.gov (United States)

    Sun, Qing; Schwartz, François; Michel, Jacques; Herve, Yannick; Dalmolin, Renzo

    2011-06-01

    In this paper, we aim at developing an analog spiking neural network (SNN) for reinforcing the performance of conventional cardiac resynchronization therapy (CRT) devices (also called biventricular pacemakers). Targeting an alternative analog solution in 0.13- μm CMOS technology, this paper proposes an approach to improve cardiac delay predictions in every cardiac period in order to assist the CRT device to provide real-time optimal heartbeats. The primary analog SNN architecture is proposed and its implementation is studied to fulfill the requirement of very low energy consumption. By using the Hebbian learning and reinforcement learning algorithms, the intended adaptive CRT device works with different functional modes. The simulations of both learning algorithms have been carried out, and they were shown to demonstrate the global functionalities. To improve the realism of the system, we introduce various heart behavior models (with constant/variable heart rates) that allow pathologic simulations with/without noise on the signals of the input sensors. The simulations of the global system (pacemaker models coupled with heart models) have been investigated and used to validate the analog spiking neural network implementation.

  18. In vitro and in vivo studies of the effects of halogenated histidine analogs on Plasmodium falciparum.

    Science.gov (United States)

    Panton, L J; Rossan, R N; Escajadillo, A; Matsumoto, Y; Lee, A T; Labroo, V M; Kirk, K L; Cohen, L A; Aikawa, M; Howard, R J

    1988-11-01

    The effects of four halogenated analogs of histidine on in vitro growth of Plasmodium falciparum malaria parasites were monitored by measurement of the incorporation of 3H-labeled amino acids into parasite proteins and by light and electron microscopy. The uptake of [3H]isoleucine was reduced to 50% of the control value by addition of 70 microM 2-fluoro-L-histidine (2-F-HIS) or 420 microM 2-iodo-L-histidine (2-I-HIS). [3H]histidine uptake into acid-insoluble material was affected equally by these two compounds, 50% inhibition resulting at 200 microM concentration. Morphological analysis of parasite development proved a sensitive assay, since development of mature trophozoites was inhibited 50% by 25 microM 2-F-HIS or 100 2-I-HIS. Electron microscopy studies suggested different mechanisms of action of 2-F-HIS and 2-I-HIS on P. falciparum. 2-F-HIS produced a decrease in knob number at the erythrocyte surface and accumulation of electron-dense material under the parasite membrane. 2-I-HIS had no obvious effect on knobs or electron-dense material but affected parasite morphology. Surprisingly, 2-chloro-L-histidine and 2-bromo-L-histidine did not inhibit P. falciparum in vitro, even though their halogen atom substituents are intermediate in size between F and I atoms. 2-F-HIS and 2-I-HIS were tested in vivo against P. falciparum in owl monkeys (Aotus sp.) but were ineffective at doses that were nontoxic.

  19. Preliminary Study on the Establishment of Regulatory Infrastructure for a Commercial SMART Licensing

    Energy Technology Data Exchange (ETDEWEB)

    Yune, Young Gill; Roh, Kyung Wan; Kang, Dong Gu; Kim, Hho Jung; Jo, Jong Chull [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2007-10-15

    The SMART, an integral type of PWR with the capacity of 330MWth, has been developed for multi-purposes such as seawater desalination, ship propulsion, and district heating in Korea since early 1990s. The basic design of the SMART had been completed in 2002. For the demonstration of the safety and performance of the SMART, a project to construct a 1/5 scaled-down prototype reactor with capacity of 65MWth, called as SMART-P(SMART Pilot Plant), has been performed from 2002 to 2006. However, in 2006, the project to construct the SMART-P was replaced with a preliminary project to develop a commercial SMART in order to advance commercialization of the SMART. Since the SMART is the first commercial reactor adopting the integral design concept and new system/components such as passive residual heat removal system, canned motor pump, and helical tube steam generator in Korea, some verification tests need to be performed to demonstrate the safety and performance of the SMART. Also, since several new design computer codes that have not yet been confirmed by the regulatory body are expected to be used in the design, some validation tests should be performed to demonstrate their applicability for important accident phenomena. In order to carry out the SMART development project satisfactorily and to prevent any undesirable delay of licensing process, it is necessary to establish a well-planned verification test program in advance through the early identification of the scope and items of the verification tests. Also, the issues for which either policy decision-makings or detailed technical evaluations are needed should be identified in an early stage of design, and the regulatory positions for the issues should be provided either timely or in advance. Advance identification of regulatory requirements/guides to be amended or newly developed enables to provide regulatory directions for such items in the early stage of design. The objective of this paper is to introduce the current

  20. Fractured reservoir analogs: case study of paelocirculation markers on Tamariu's Granite.

    Science.gov (United States)

    Bertrand, Lionel; Legarzic, Edouard; Geraud, Yves; Diraison, Marc

    2013-04-01

    In fractured crystalline reservoirs, the grain matrix has in general a very low permeability and the fluid flow is localized in the fracture pattern. The flow in such fracture network is generally complicated to characterize, in on hand because many parameters (length, connectivity, aperture, tortuosity,…) are acting on the fluid flow, in other hand because the fractures at a reservoir scale using seismic data are not easy to characterize. In fact, the only information we have on fracture in buried reservoir are at a local scale with boreholes and at a kilometric scale with seismic. The study of field analogs is one way to establish a better comprehension of the fracture pattern between those two scales. Regional and outcrop studies on Tamariu's granite, which outcrops on the Catalonian Coastal Ranges, has permit the characterization of the faults and fractures at different scales. The faults network defines different sizes of structural blocks bordered by faults. In an unfaulted structural block, the granite exhibits a fracture network filled with hydrothermal carbonates, markers of important paleofluid circulation. These carbonates were analysed at different scales using fracture mapping, calcimetry and microscopy on thin- sections in order to define the location and the volume of the carbonates precipitation and to have an estimation of the paleo-porosity used by the fluids in the fracture network. With precise fracture maps, we analysed the principal flow direction and the nature of the hydrothermal deposits. The same maps, combined with calcimetry measurements, allow us to quantify the 2D volume of porosity used by the paleofluids. We have quantified the carbonates in different areas of percolation: the main veins, breccias cimented by carbonates, fractured granite and poorly fractured granite. The percentage of paleofluids markers reaches to 3% of the granitic rock, and the main part of them are localized in some fractured corridor composed of mains veins

  1. Neutron-skin thickness from the study of the anti-analog giant dipole resonance

    Science.gov (United States)

    Krasznahorkay, A.; Stuhl, L.; Csatlós, M.; Algora, A.; Gulyás, J.; Timár, J.; Paar, N.; Vretenar, D.; Harakeh, M. N.; Boretzky, K.; Heil, M.; Litvinov, Yu. A.; Rossi, D.; Scheidenberger, C.; Simon, H.; Weick, H.; Bracco, A.; Brambilla, S.; Blasi, N.; Camera, F.; Giaz, A.; Million, B.; Pellegri, L.; Riboldi, S.; Wieland, O.; Altstadt, S.; Fonseca, M.; Glorius, J.; Göbel, K.; Heftrich, T.; Koloczek, A.; Kräckmann, S.; Langer, C.; Plag, R.; Pohl, M.; Rastrepina, G.; Reifarth, R.; Schmidt, S.; Sonnabend, K.; Weigand, M.; Kalantar-Nayestanaki, N.; Rigollet, C.; Bagchi, S.; Najafi, M. A.; Aumann, T.; Atar, L.; Heine, M.; Holl, M.; Movsesyan, A.; Schrock, P.; Volkov, V.; Wamers, F.; Fiori, E.; Löher, B.; Marganiec, J.; Savran, D.; Johansson, H. T.; Fernández, P. Diaz; Garg, U.; Balabanski, D. L.

    2012-10-01

    The γ-decay of the anti-analog of the giant dipole resonance (AGDR) to the isobaric analog state has been measured following the p(124Sn,n) reaction at a beam energy of 600 MeV/nucleon. The energy of the transition was also calculated with state-of-the-art self-consistent relativistic random-phase approximation (RPA) and turned out to be very sensitive to the neutronskin thickness (ΔRpn). By comparing the theoretical results with the measured one, the ΔRpn value for 124Sn was deduced to be 0.21 ± 0.07 fm, which agrees well with the previous results. The present method offers new possibilities for measuring the neutron-skin thicknesses of very exotic isotopes.

  2. Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study

    Science.gov (United States)

    Lebov, Jill F.; Engel, Lawrence S.; Richardson, David; Hogan, Susan L.; Hoppin, Jane A.; Sandler, Dale P.

    2017-01-01

    Objectives Experimental studies suggest a relationship between pesticide exposure and renal impairment, but epidemiological evidence is limited. We evaluated the association between exposure to 41 specific pesticides and end-stage renal disease (ESRD) incidence in the Agricultural Health Study (AHS), a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. Methods Via linkage to the United States Renal Data System, we identified 320 ESRD cases diagnosed between enrollment (1993-1997) and December 2011 among 55,580 male licensed pesticide applicators. Participants provided pesticide use information via self-administered questionnaires. Lifetime pesticide use was defined as the product of duration and frequency of use and then modified by an intensity factor to account for differences in pesticide application practices. Cox proportional hazards models, adjusted for age and state, were used to estimate associations between ESRD and: 1) ordinal categories of intensity-weighted lifetime use of 41 pesticides, 2) poisoning and high-level pesticide exposures, and 3) pesticide exposure resulting in a medical visit or hospitalization. Results Positive exposure-response trends were observed for the herbicides alachlor, atrazine, metolachlor, paraquat, and pendimethalin, and the insecticide chlordane. More than one medical visit due to pesticide use (HR = 2.13; 95% CI: 1.17, 3.89) and hospitalization due to pesticide use (HR = 3.05; 95% CI: 1.67, 5.58) were significantly associated with ESRD. Conclusions Our findings support an association between ESRD and chronic exposure to specific pesticides and suggest pesticide exposures resulting in medical visits may increase the risk of ESRD. PMID:26177651

  3. EXTENSION THROUGH ANALOGY A USEFUL METHOD IN THE STUDY OF DISPARITIES

    Directory of Open Access Journals (Sweden)

    Viorica PUSCACIU

    2006-01-01

    Full Text Available The method of extension through analogy is, in our view, useful for comparisons between miscellaneous economical indicators belonging to the same structure, also between indicators which belongs to various economical areas like cities, regions, countries. Taking into account Romania’s admission to the European Union, this method would establish the extant temporary disparities and would impress those responsible in the political economy. As a novelty we present it inthe context of square trends.

  4. Filed-Analog Study: Efficiency of microbial fossilization in sulfate-rich playas

    Science.gov (United States)

    Glamoclija, M.; Zeidan, M.; Potochniak, S.

    2015-12-01

    The samples with the highest priority for sample return will be samples that contain potential life signatures. Sulfate-rich salts have been identified as important component of Mars sedimentary deposits, illustrating the importance of near-surface hydrological processes during the planet's history. The presence of Noachian/early Hesperian sulfate-rich deposits have been identified by the MER's Opportunity at Meridiani Planum and by MRO mission in sedimentary sequences within Gale crater, the Mars Science Laboratory landing site. White Sands National Monument, which we are using as a terrestrial analog in our study, holds active playas that may contain different sizes of water bodies during the year. Alkali Flat contains also preserved deposits of Pleistocene Lake Otero. The presence of a range of modern playas and equivalent Pleistocene deposits allows for an excellent comparison of these different extreme transitional habitats and potential of preservation of organics in an evaporitic playa setting. We have performed shallow drilling (1m) of the Lake Lucero deposits and of Lake Otero evaporitic sequence. The XRD analysis revealed that samples are mainly composed of gypsum and minor mineral phases as brushite, halite and quartz. SEM/EDS revealed the presence of amorphous phases such as halite, glauberite, magnesium chlorite salt, and diatom shells and biofilm. Biofilm is found in near surface samples, which may be attributed to microbial adaptation to desert environment and considered as one of the characteristics of modern and not fossil microbial communities. The compositional difference of salt precipitates associated with potentially geologically old biofilm and the modern counterpart are still ongoing and our findings will be presented at the conference. Further, comparison of environmental physicochemical conditions and molecular biology will be used to determine the characteristics of modern microbial habitats/deposits and to attempt to distinguish them

  5. Problem gambling and the circumstances facing older people : a study of gaming machine players aged 60+ in licensed clubs.

    Science.gov (United States)

    Southwell, Jenni; Boreham, Paul; Laffan, Warren

    2008-06-01

    Local gambling venues are an important contemporary context for older people's gambling in many parts of the world typically being more accessible to this segment of the population than traditional, centralised gambling venues, such as casinos. This study, undertaken in South East Queensland, analyses older people's electronic gaming machine (EGM) behaviour and motivations, specifically in the context of licensed social and recreational clubs-a popular local gambling venue in many parts of Australia. The study gathered data via a postal survey of 80 managers of licensed clubs, interviews with Gambling Help services and a survey of 414 people aged 60+ who regularly play EGMs, self-administered on site at local clubs. The analysis undertaken suggests that certain age-related circumstances of older people-such as being without a partner, having a disability that impacts on everyday activities, having a low annual income, and no longer participating in the workforce-are associated with higher overall levels of motivation for playing EGMs and greater reliance on EGMs to meet social, recreational and mental health needs. Over a quarter of the older people surveyed (27%) reported drawing on their savings to fund their EGM gambling. Certain categories of older people, including those who were without a partner and those with a disability, were more likely to report drawing on their savings to fund EGM play and betting more than they could afford to lose, pointing to age-related vulnerabilities older people may experience to the negative impacts of gambling given the greater likelihood of their dependency on smaller, fixed incomes. The explanatory contribution of a range of demographic and motivational variables on problem/moderate risk gambling status was computed via a logistic regression model. Younger age (60-69), male gender, single marital status and being motivated to play EGMs to experience excitement and to win money all emerged as significant predictors in the

  6. Eryptosis-inducing activity of bisphenol A and its analogs in human red blood cells (in vitro study).

    Science.gov (United States)

    Maćczak, Aneta; Cyrkler, Monika; Bukowska, Bożena; Michałowicz, Jaromir

    2016-04-15

    Bisphenols are important chemicals that are widely used in the manufacturing of polycarbonates, epoxy resin and thermal paper, and thus the exposure of humans to these substances has been noted. The purpose of this study was to assess eryptotic changes in human erythrocytes exposed (in vitro) to bisphenol A (BPA) and its selected analogs, i.e.,bisphenol F (BPF), bisphenol S (BPS) and bisphenol AF (BPAF). The erythrocytes were incubated with compounds studied at concentrations ranging from 1 to 250μg/mL for 4, 12 or 24h. The results showed that BPA and its analogs increased cytosolic calcium ions level with the strongest effect noted for BPAF. It has also been revealed that all bisphenols analyzed, and BPAF and BPF in particular increased phosphatidylserine translocation in red blood cells, which confirmed that they exhibited eryptotic potential in this cell type. Furthermore, it was shown that BPA and its analogs caused significant increase in calpain and caspase-3 activities, while the strongest effect was noted for BPAF. BPS, which is the main substituent of bisphenol A in polymers and thermal paper production exhibited similar eryptotic potential to BPA. Eryptotic changes in human erythrocytes were provoked by bisphenols at concentrations, which may influence the human body during occupational exposure or subacute poisoning with these compounds.

  7. Learning-by-Licensing: How Chinese Firms Benefit From Licensing-In Technologies

    DEFF Research Database (Denmark)

    Wang, Yuandi; Roijakkers, N.; Vanhaverbeke, W.

    2012-01-01

    performance lies in differences of absorptive capacity. In this study, we intend to relax this assumption and use data about 186 Chinese indigenous firms to investigate how differences in in-licensing portfolios lead to different effects on innovation performance. We find that firms benefit from prior in......This paper explores how interfirm variations in their in-licensed technology portfolios influence subsequent innovation performance. Existing studies mainly assume licensed technologies are homogeneously accessible to firms, and a prevailing explanation as to why firms vary in their innovation......-licensing technologies and the result is related to four dimensions of their licensing portfolios. We find that 1) the scale of firms' technology in-licensing has an inverted-U relationship with their subsequent innovation performance; 2) firms that license-in foreign technologies tend to outperform those...

  8. Driving Performance among Bioptic Telescope Users with Low Vision Two Years after Obtaining Their Driver's License: A Quasi-Experimental Study

    Science.gov (United States)

    Vincent, Claude; Lachance, Jean-Paul; Deaudelin, Isabelle

    2012-01-01

    This study sought to compare road safety of new drivers with low vision who have followed a specific pilot bioptic training program with other groups of drivers all matched for age and driving experience. A quasi-experimental design was used two years after drivers obtained their license. Drivers were classified in the experimental group (n = 10,…

  9. The neural basis of analogical reasoning: an event-related potential study.

    Science.gov (United States)

    Qiu, Jiang; Li, Hong; Chen, Antao; Zhang, Qinglin

    2008-10-01

    The spatiotemporal analysis of brain activation during the execution of easy analogy (EA) and difficult analogy (DA) tasks was investigated using high-density event-related brain potentials (ERPs). Results showed that reasoning tasks (schema induction) elicited a more negative ERP deflection (N500-1000) than did the baseline task (BS) between 500 and 1000 ms. Dipole source analysis of difference waves (EA-BS and DA-BS) indicated that the negative components were both localized near the left thalamus, possibly associated with the retrieval of alphabetical information. Furthermore, DA elicited a more positive ERP component (P600-1000) than did EA in the same time window. Two generators of P600-1000 were located in the medial prefrontal cortex (BA10) and the left frontal cortex (BA6) which was possibly involved in integrating information in schema abstraction. In the stage of analogy mapping, a greater negativity (N400-600) in the reasoning tasks as compared to BS was found over fronto-central scalp regions. A generator of this effect was located in the left fusiform gyrus and was possibly related to associative memory and activation of schema. Then, a greater negativity in the reasoning tasks, in comparison to BS task, developed between 900-1200 ms (LNC1) and 2000-2500 ms (LNC2). Dipole source analysis (EA-BS) localized the generator of LNC1 in the left prefrontal cortex (BA 10) which was possibly related to mapping the schema to the target problem, and the generator of LNC2 in the left prefrontal cortex (BA 9) which was possibly related to deciding whether a conclusion correctly follows from the schema.

  10. 10 CFR 72.6 - License required; types of licenses.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License required; types of licenses. 72.6 Section 72.6... Provisions § 72.6 License required; types of licenses. (a) Licenses for the receipt, handling, storage, and transfer of spent fuel or high-level radioactive waste are of two types: general and specific. Licenses...

  11. In vitro and in vivo studies of the effects of halogenated histidine analogs on Plasmodium falciparum.

    OpenAIRE

    Panton, L J; Rossan, R N; Escajadillo, A; Matsumoto, Y; Lee, A.T.; Labroo, V M; Kirk, K L; Cohen, L. A.; Aikawa, M.; Howard, R J

    1988-01-01

    The effects of four halogenated analogs of histidine on in vitro growth of Plasmodium falciparum malaria parasites were monitored by measurement of the incorporation of 3H-labeled amino acids into parasite proteins and by light and electron microscopy. The uptake of [3H]isoleucine was reduced to 50% of the control value by addition of 70 microM 2-fluoro-L-histidine (2-F-HIS) or 420 microM 2-iodo-L-histidine (2-I-HIS). [3H]histidine uptake into acid-insoluble material was affected equally by t...

  12. Establishment of licensing process for development reactors

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Jong Chull; Yune, Young Gill; Kim, Woong Sik (and others)

    2006-02-15

    A study on licensing processes for development reactors has been performed to prepare the licensing of development reactors developed in Korea. The contents and results of the study are summarized as follows. The licensing processes for nuclear reactors in Korea, U.S.A., Japan, France, U.K., Canada, and IAEA were surveyed and analyzed to obtain technical bases necessary for establishing licensing processes applicable to development reactors in Korea. Based on the technical bases obtained the above analysis, the purpose, power output, and design characteristics of development reactors were analyzed in detail. The analysis results suggested that development reactors should be classified as a new reactor category (called as 'development reactor') separated from the current reactor categories such as the research reactor and the power reactor. Therefore, it is proposed to establish a new reactor category classified as 'development reactor' for the development reactors. And licensing processes, including licensing technical requirements, licensing document requirements, and other regulatory requirements, were also proposed for the development reactors. In order to institutionalize the licensing processes developed in this study, it is necessary to revise the current laws. Therefore, draft provisions of Atomic Energy Act, Enforcement Decree of the Atomic Energy Act, and Enforcement Regulation of the Atomic Energy Act have been developed for the preparation of the future legalization of the licensing processes proposed for the development reactors. Conclusively, a proposal of licensing processes and draft provisions of laws have been developed for the development reactors. The results proposed in this study can be applied directly to the licensing of the future development reactors. Furthermore, they will also contribute to establishing successfully the licensing processes of the development reactors.

  13. State Licenses & Permits

    Data.gov (United States)

    Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

  14. Technology licensing in China

    DEFF Research Database (Denmark)

    Wang, Yuandi; Li-Ying, Jason; Chen, Jin

    2015-01-01

    We explore the landscape of technology licensing among Chinese entities in the period 2000–12, using a unique database on technological licensing from the State Intellectual Property Office of China. We find that: first, among Chinese licensee organizations, firms have dominated in terms...... of the number of licensed technologies; second, the geographical distribution of licensed technologies among the provinces has gradually reached a new quantitative balance; third, utility models are the most popular technologies to be licensed and the majority of technology licensing in China has been between...... Chinese entities, and most transactions have been local within provinces; and finally, Chinese firms have gradually in-licensed newer and newer technologies, but the technologies in-licensed from foreign sources are by no means state-of-the-art. We make several suggestions for innovation policy...

  15. 2-(pyrazin-2-yloxy)acetohydrazide analogs QSAR Study: An insight into the structural basis of antimycobacterial activity.

    Science.gov (United States)

    Gupta, Revathi A; Gupta, Arun K; Soni, Love K; Kaskhedikar, Satish Gopalrao

    2010-11-01

    Quantitative structure activity relationship analysis based on classical Hansch approach was adopted on reported novel series of 2-(pyrazin-2-yloxy)acetohydrazide analogs. Various types of descriptors like topological, spatial, thermodynamic, and electronic were used to derive a quantitative relationship between the antitubercular activity and structural properties. The consensus scoring function showed a significant statistics of training and test set. Coefficient of determination (r²) of consensus model and predictive squared correlation coefficient (r²(pred)) were found to be 0.889 and 0.782, respectively. The model is not only able to predict the activity of test compounds but also explained the important structural features of the molecules in a quantitative manner. The study revealed that antimycobacterium activity is predominantly explained by the molecular connectivity indices of length 6, hydrogen donor feature of the analogs, and shape factors of the substituent. The comparative investigation of antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Salmonella typhi provided structural insights on how modulation of the molecular connectivity indices, energy of lowest unoccupied molecular orbital, accessible surface area, and moment of inertia of the analogs could be usefully made to optimize the antibacterial activity.

  16. Interactions of biocidal guanidine hydrochloride polymer analogs with model membranes: a comparative biophysical study

    Institute of Scientific and Technical Information of China (English)

    Zhongxin Zhou; Anna Zheng; Jianjiang Zhong

    2011-01-01

    Four synthesized biocidal guanidine hydrochloride polymers with different alkyl chain length,including polyhexamethylene guanidine hydrochloride and its three new analogs,were used to investigate their interactions with phospholipids vesicles mimicking bacterial membrane.Characterization was conducted by using fluorescence dye leakage,isothermal titration calorimetry,and differential scanning calorimetry.The results showed that the gradually lengthened alkyl chain of the polymer increased the biocidal activity,accompanied with the increased dye leakage rate and the increased binding constant and energy change value of polymer-membrane interaction.The polymer-membrane interaction induced the change of pretransition and main phase transition (decreased temperature and increased width) of phospholipids vesicles,suggesting the conformational change in the phospholipids headgroups and disordering in the hydrophobic regions of lipid membranes.The above information revealed that the membrane disruption actions of guanidine hydrochloride polymers are the results of the polymer's strong binding to the phospholipids membrane and the subsequent perturbations of the polar headgroups and hydrophobic core region of the phospholipids membrane.The alkyl chain structure significantly affects the binding constant and energy change value of the polymer-membrane interactions and the perturbation extent of the phospholipids membrane,which lead to the different biocidal activity of the polymer analogs.This work provides important information about the membrane disruption action mechanism of biocidal guanidine hydrochloride polymers.

  17. Licensing of Practices

    CERN Document Server

    2001-01-01

    All practices are licensed by Radiation Protection Centre (RPC). RPC verifies if license seeker is prepares to work with sources in an adequate and safe manner. Types of licences defined in the Republic of Lithuania are listed. Data on the number of licensees and of licenses issued in 1999-2001 is presented.

  18. Licensing-In Fosters Rapid Invention!

    DEFF Research Database (Denmark)

    Leone, Maria Isabella; Reichstein, Toke

    2012-01-01

    Drawing on contractual economics and innovation management, licensing-in is hypothesized to accelerate licensees' invention process. Studying a matched dataset of licensees and non-licensees, licensees are shown to be faster at inventing, but the effect is negated if the license includes a grant......-back clause, shifting incentives from licensee to licensor. Also, the effect is significantly reduced if the licensee is unfamiliar with the licensed technology. The effect of the grant-back clause is offset if the licensee is unfamiliar with the licensed technology, suggesting that the licensee retains...

  19. Licensing to Market with Logit Demand Functions

    Institute of Scientific and Technical Information of China (English)

    YAN Qing-you; ZHU Li-li

    2009-01-01

    This paper studies the licensing of a brand innovation to a monopoly in an uncovered market characterized by a logit demand framework. The innovator is an outsider to the market and sells the license via fixed-fee, royalty or their combinations. It is shown that the license occurs irrespective of whether the utility of the new brand is improved or not, and that the optimal licensing policy for the innovator is fixed-fee only. Ultimately, the monopoly produces both the old and the new brand products, even in the case of utility-improving brand innovation. In addition, the incentive for the innovator was examined.

  20. The 2012 Transit of Venus for Cytherean Atmospheric Studies and as an Exoplanet Analog

    Science.gov (United States)

    Pasachoff, Jay M.; Schneider, G.; Babcock, B. A.; Lu, M.; Reardon, K. P.; Widemann, T.; Tanga, P.; Dantowitz, R.; Willson, R.; Kopp, G.; Yurchyshyn, V.; Sterling, A.; Scherrer, P.; Schou, J.; Golub, L.; Reeves, K.

    2012-10-01

    We worked to assemble as complete a dataset as possible for the Cytherean atmosphere in collaboration with Venus Express in situ and to provide an analog of spectral and total irradiance exoplanet measurements. From Haleakala, the whole transit was visible in coronal skies; our B images showed the evolution of the visibility of Venus's atmosphere and of the black-drop effect, as part of the Venus Twilight Experiment's 9 coronagraphs distributed worldwide with BVRI. We imaged the Cytherean atmosphere over two minutes before first contact, with subarcsecond resolution, with the coronagraph and a separate refractor. The IBIS imaging spectrometer at Sacramento Peak Observatory at H-alpha and carbon-dioxide also provided us high-resolution imaging. The NST of Big Bear Solar Observatory also provided high-resolution vacuum observations of the Cytherean atmosphere and black drop evolution. Our liaison with UH's Mees Solar Observatory scientists provided magneto-optical imaging at calcium and potassium. Spaceborne observations included the Solar Dynamics Observatory's AIA and HMI, and the Solar Optical Telescope (SOT) and X-ray Telescope (XRT) on Hinode, and total-solar-irradiance measurements with ACRIMSAT and SORCE/TIM, to characterize the event as an exoplanet-transit analog. Our expedition was sponsored by the Committee for Research and Exploration/National Geographic Society. Some of the funds for the carbon-dioxide filter for IBIS were provided by NASA through AAS's Small Research Grant Program. We thank Rob Lucas, Aram Friedman, and Eric Pilger '82 for assistance with Haleakala observing, Rob Ratkowski of Haleakala Amateur Astronomers for assistance with equipment and with the site, Stan Truitt for the loan of his Paramount ME, and Steve Bisque/Software Bisque for TheSky X controller. We thank Joseph Gangestad '06 of Aerospace Corp., a veteran of our 2004 expedition, for assistance at Big Bear. We thank the Lockheed Martin Solar and Astrophysics Laboratory and

  1. Licensing in the Patent Thicket - Timing and Benefits

    OpenAIRE

    Siebert, Ralph Bernd; Graevenitz, Georg von

    2011-01-01

    Licensing can be a solution for hold-up in patent thickets. In this paper we study whether licensing is an effective solution for hold-up. To do this we distinguish between ex ante and ex post licensing. A theoretical model shows that firms’ expectations of blocking in a patent thicket determine whether they license ex ante while ex post licensing arises if expected blocking was low but realized blocking turns out to be high. It can also be shown that ex ante licensing will allow firms to ...

  2. Bisphenol A and its analogs exhibit different apoptotic potential in peripheral blood mononuclear cells (in vitro study).

    Science.gov (United States)

    Mokra, Katarzyna; Kocia, Magdalena; Michałowicz, Jaromir

    2015-10-01

    There are only a few studies that have assessed the effect of bisphenol A (BPA) on human blood cells and no study has been conducted to analyze the impact of BPA analogs on human leucocytes. In this study, we have investigated the effect of BPA and its analogs like bisphenol F (BPF), bisphenol S (BPS) and bisphenol AF (BPAF) on apoptosis induction in human peripheral blood mononuclear cells (PBMCs). In order to clarify the mechanism of bisphenols-induced programmed cell death, changes in various signaling molecules of this process have been assessed. We observed an increase in cytosolic calcium ions (Ca(2+)) level and reduction of transmembrane mitochondrial potential (ΔΨm) in PBMCs incubated with all compounds examined, and particularly BPA and BPAF. All compounds studied changed PBMCs membrane permeability, activated caspase-8, -9, -3 and induced PARP-1 cleavage and chromatin condensation, which confirmed that they were capable of inducing apoptosis both via intrinsic and extrinsic pathway. Moreover, we have found that modus operandi of bisphenols studied was different. We noticed that BPAF and BPS caused mainly necrotic and apoptotic changes, respectively, whereas BPA induced comparable apoptotic and necrotic effects in the incubated cells.

  3. A Study of an Architecture Design Learning Process Based on Social Learning, Course Teaching, Interaction, and Analogical Thinking

    Directory of Open Access Journals (Sweden)

    Yun-Wu Wu

    2014-01-01

    Full Text Available The students in the vocational education of architecture design in Taiwan often face many learning obstacles, such as no problem solving ability and lack of creativity. Therefore, this study used a social learning model as a learning strategy in the architecture design learning process to solve related learning difficulties. Firstly, this study used cognitive development teaching activities and a learning process based on analogical thinking and analogical reasoning to build the social learning model. Secondly, the social learning model of this study was implemented in the teaching of a required course of architecture design for 120 freshmen in China University of Technology. The questionnaire survey results were then statically analyzed and compared to measure the differences in the students’ knowledge about architecture designs before and after the teaching in this study. In this study, the social learning model is proven helpful in inspiring the students’ creativity by converting new knowledge of architecture design into schemas and hence retaining the new knowledge for future application. The social learning model can be applied in the teaching of architecture design in other schools, while more research can be conducted in the future to further confirm its feasibility to promote effective learning.

  4. Mathematical problem solving by analogy.

    Science.gov (United States)

    Novick, L R; Holyoak, K J

    1991-05-01

    We report the results of 2 experiments and a verbal protocol study examining the component processes of solving mathematical word problems by analogy. College students first studied a problem and its solution, which provided a potential source for analogical transfer. Then they attempted to solve several analogous problems. For some problems, subjects received one of a variety of hints designed to reduce or eliminate the difficulty of some of the major processes hypothesized to be involved in analogical transfer. Our studies yielded 4 major findings. First, the process of mapping the features of the source and target problems and the process of adapting the source solution procedure for use in solving the target problem were clearly distinguished: (a) Successful mapping was found to be insufficient for successful transfer and (b) adaptation was found to be a major source of transfer difficulty. Second, we obtained direct evidence that schema induction is a natural consequence of analogical transfer. The schema was found to co-exist with the problems from which it was induced, and both the schema and the individual problems facilitated later transfer. Third, for our multiple-solution problems, the relation between analogical transfer and solution accuracy was mediated by the degree of time pressure exerted for the test problems. Finally, mathematical expertise was a significant predictor of analogical transfer, but general analogical reasoning ability was not. The implications of the results for models of analogical transfer and for instruction were considered.

  5. Experimental Validation of RELAP5 and TRACE5 for Licensing Studies of the Boron Injection System of Atucha II

    Directory of Open Access Journals (Sweden)

    Alejandro I. Lazarte

    2011-01-01

    Full Text Available This paper presents an experimental validation of RELAP5 and TRACE5 for licensing studies of the Atucha II-PHWR nuclear power plant. A scaled experimental facility, representing the boron injection system of Atucha II, was built. The system has a fundamental importance for loss of coolant accidents (LOCA and anticipated transients without scram (ATWS. The experiment consists of the discharge of a tank that represents the boron tank filled with air or a mixture of air-water onto a discharge tank that represents the moderator tank. Both tanks are connected by a pipe which includes a valve and an orifice plate to model the pressure losses due to the fittings in the real system. The pressure and water level measured in the tanks are compared with the RELAP5 and TRACE5 predictions. The codes predict the pressure in the tanks accurately. However, both codes overpredict the heat transfer in the boron tank air-water interface which produces a greater expansion of the air which leads to a small discrepancy in the boron tank level prediction.

  6. Effects of Four Formulations of Prostaglandin Analogs on Eye Surface Cells. A Comparative Study.

    Directory of Open Access Journals (Sweden)

    Fernando Pérez-Roca

    Full Text Available We evaluated the cytotoxic effects of four prostaglandin analogs (PGAs used to treat glaucoma. First we established primary cultures of conjunctival stromal cells from healthy donors. Then cell cultures were incubated with different concentrations (0, 0.1, 1, 5, 25, 50 and 100% of commercial formulations of bimatoprost, tafluprost, travoprost and latanoprost for increasing periods (5 and 30 min, 1 h, 6 h and 24 h and cell survival was assessed with three different methods: WST-1, MTT and calcein/AM-ethidium homodimer-1 assays. Our results showed that all PGAs were associated with a certain level of cell damage, which correlated significantly with the concentration of PGA used, and to a lesser extent with culture time. Tafluprost tended to be less toxic than bimatoprost, travoprost and latanoprost after all culture periods. The results for WST-1, MTT and calcein/AM-ethidium homodimer-1 correlated closely. When the average lethal dose 50 was calculated, we found that the most cytotoxic drug was latanoprost, whereas tafluprost was the most sparing of the ocular surface in vitro. These results indicate the need to design novel PGAs with high effectiveness but free from the cytotoxic effects that we found, or at least to obtain drugs that are functional at low dosages. The fact that the commercial formulation of tafluprost used in this work was preservative-free may support the current tendency to eliminate preservatives from eye drops for clinical use.

  7. Here, There, and Everywhere: A Case Study of Science through Analogy, Near and Far

    Science.gov (United States)

    Watzke, M.; Arcand, K.

    2014-07-01

    Here, There, and Everywhere (HTE) is a program that consists of a series of exhibitions, posters, and supporting hands-on activities that utilize analogies in the teaching of science, engineering, and technology to provide multi-generational and family-friendly content in English and Spanish to small community centers, libraries, and under-resourced small science centers. The purpose of the program is to connect crosscutting science content (in earth, atmospheric and planetary sciences, and astrophysics) with everyday phenomena. By using different modes of content delivery (physical exhibits and handouts, interpretive stations, facilitated activities for educators, and online resources), HTE helps to demonstrate the universality of physical laws and the connection between our everyday world and the universe as a whole to members of the public who may not identify strongly with science. HTE is part of a series of so-called public science projects created and developed by the Education and Public Outreach (EPO) group at the Chandra X-ray Center (CXC). This paper will outline how HTE fits into the lineage of this particular type of science outreach that aims to engage the greater public in non-traditional venues for science learning and appreciation.

  8. Uptake of radiolabeled morphiceptin and its analogs by experimental mammary adenocarcinoma: in vitro and in vivo studies

    Energy Technology Data Exchange (ETDEWEB)

    Mirowski, M. E-mail: mirowski@ich.pharm.am.lodz.pl; Wiercioch, R.; Janecka, A.; Balcerczak, E.; Byszewska, E.; Birnbaum, G.; Byzia, Sz.; Garnuszek, P.; Wierzbicki, R

    2004-05-01

    Morphiceptin (Tyr-Pro-Phe-Pro-NH{sub 2}) and its analogs modified at position 3: [D-Phe{sup 3}]morphiceptin, [D-ClPhe{sup 3}]morphiceptin and [D-Cl{sub 2}Phe{sup 3}]morphiceptin were synthesized and labeled with [{sup 125}I] or [{sup 131}I]. Their binding to membranes isolated from experimental adenocarcinoma was examined in vitro with the use of a cross-linking assay followed by the Western blot technique. The radioactive complex had molecular weight of about 65 kDa and was detectable by anti-{mu}-opioid receptor polyclonal antibody. Expression of the {mu}-opioid receptor in mouse mammary adenocarcinoma was confirmed by reverse transcriptase-polymerase chain reaction. The binding studies showed the highest affinity and capacity for [D-Phe{sup 3}]morphiceptin (K{sub d} 0.39 and B{sub max} 1112) and [D-ClPhe{sup 3}]morphiceptin (K{sub d} 1.8 and B{sub max} 220). Morphiceptin and its D-Cl{sub 2}Phe analog had significantly lower B{sub max} values (131 and 83, respectively). Biodistribution experiments in tumor-bearing C3H/Bi mice with the use of the {sup 131}I-labeled peptides confirmed the results of our in vitro studies. The highest accumulation of radioactive peptides in the tumor tissue was also found for peptides with D-Phe and D-ClPhe.

  9. Studies on azaspiracid biotoxins. II. Mass spectral behavior and structural elucidation of azaspiracid analogs.

    Science.gov (United States)

    Brombacher, Stephan; Edmonds, Suzanne; Volmer, Dietrich A

    2002-01-01

    In this report, the mass spectral analysis of azaspiracid biotoxins is described. Specifically, the collision-induced dissociation (CID) behavior and differences between CID spectra obtained on a triple-quadrupole, a quadrupole time-of-flight, and an ion-trap mass spectrometer are addressed here. The CID spectra obtained on the triple-quadrupole mass spectrometer allowed the classification of the major product ions of the five investigated compounds (AZA 1-5) into five distinct fragment ion groups, according to the backbone cleavage positions. Although the identification of unknown azaspiracids was difficult based on CID alone, the spectra provided sufficient structural information to allow confirmation of known azaspiracids in marine samples. Furthermore, we were able to detect two new azaspiracid analogs (AZA 1b and 6) in our samples and provide a preliminary structural analysis. The proposed dissociation pathways under tandem mass spectrometry (MS/MS) conditions were confirmed by a comparison with accurate mass data from electrospray quadrupole time-of-flight MS/MS experiments. Regular sequential MS(n) analysis on an ion-trap mass spectrometer was more restricted in comparison to the triple-quadrupole mass spectrometer, because the azaspiracids underwent multiple [M + H - nH(2)O](+) (n = 1-6) losses from the precursor ion under CID. Thus, the structural information obtained from MS(n) experiments was somewhat limited. To overcome this limitation, we developed a wide-range excitation technique using a 180-u window that provided results comparable to the triple-quadrupole instrument. To demonstrate the potential of the method, we applied it to the analysis of degraded azaspiracids from mussel tissue extracts.

  10. Biopharmaceutical Characterization and Bioavailability Study of a Tetrazole Analog of Clofibric Acid in Rat

    Directory of Open Access Journals (Sweden)

    Nancy Vara-Gama

    2017-02-01

    Full Text Available In the current investigation, the physicochemical, biopharmaceutical and pharmacokinetic characterization of a new clofibric acid analog (Compound 1 was evaluated. Compound 1 showed affinity by lipophilic phase in 1 to 5 pH interval, indicating that this compound would be absorbed favorably in duodenum or jejunum. Also, Compound 1 possess two ionic species, first above of pH 4.43 and, the second one is present over pH 6.08. The apparent permeability in everted sac rat intestine model was 8.73 × 10−6 cm/s in duodenum and 1.62 × 10−5 cm/s in jejunum, suggesting that Compound 1 has low permeability. Elimination constant after an oral administration of 50 μg/kg in Wistar rat was 1.81 h−1, absorption constant was 3.05 h−1, Cmax was 3.57 μg/mL at 0.33 h, AUC0–α was 956.54 μ/mL·h and distribution volume was 419.4 mL. To IV administration at the same dose, ke was 1.21 h−1, Vd was 399.6 mL and AUC0–α was 747.81 μ/mL·h. No significant differences were observed between pharmacokinetic parameters at every administration route. Bioavailability evaluated was 10.4%. Compound 1 is metabolized to Compound 2 probably by enzymatic hydrolysis, and it showed a half-life of 9.24 h. With these properties, Compound 1 would be considered as a prodrug of Compound 2 with potential as an antidiabetic and anti dyslipidemic agent.

  11. Workshop on the role of natural analogs in geologic disposal of high-level nuclear waste: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, L.A. [ed.] [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Murphy, W.M. [ed.] [Southwest Research Inst., San Antonio, TX (United States). Center for Nuclear Waste Regulatory Analyses

    1995-09-01

    A Workshop on the Role of Natural Analogs in Geologic Disposal of High-Level Nuclear Waste was held in San Antonio, Texas on July 22--25, 1991. The proceedings comprise seventeen papers submitted by participants at the workshop. A series of papers addresses the relation of natural analog studies to the regulation, performance assessment, and licensing of a geologic repository. Applications of reasoning by analogy are illustrated in papers on the role of natural analogs in studies of earthquakes, petroleum, and mineral exploration. A summary is provided of a recently completed, internationally coordinated natural analog study at Pocos de Caldas, Brazil. Papers also cover problems and applications of natural analog studies in four technical areas of nuclear waste management-. waste form and waste package, near-field processes and environment, far-field processes and environment, and volcanism and tectonics. Summaries of working group deliberations in these four technical areas provide reviews and proposals for natural analog applications. Individual papers have been cataloged separately.

  12. Hapten-antibody recognition studies in competitive immunoassay of α-zearalanol analogs by computational chemistry and Pearson Correlation analysis.

    Science.gov (United States)

    Wang, Zhanhui; Luo, Pengjie; Cheng, Linli; Zhang, Suxia; Shen, Jianzhong

    2011-01-01

    The molecular recognition of hapten-antibody is a fundamental event in competitive immunoassay, which guarantees the sensitivity and specificity of immunoassay for the detection of haptens. The aim of this study is to investigate the correlation between binding ability of one monoclonal antibody, 1H9B4, recognizing and the molecular aspects of α-zearalanol analogs. The mouse-derived monoclonal antibody was produced by using α-zearalanol conjugated to bovine serum albumin as an immunogen. The antibody recognition abilities, expressed as IC(50) values, were determined by a competitive ELISA. All of the hapten molecules were optimized by Density Function Theory (DFT) at B3LYP/ 6-31G* level and the conformation and electrostatic molecular isosurface were employed to explain the molecular recognition between α-zearalanol analogs and antibody 1H9B4. Pearson Correlation analysis between molecular descriptors and IC(50) values was qualitatively undertaken and the results showed that one molecular descriptor, surface of the hapten molecule, clearly demonstrated linear relationship with antibody recognition ability, where the relationship coefficient was 0.88 and the correlation was significant at p Pearson Correlation analysis can be used as tool to help the immunochemistries better understand the processing of antibody recognition of hapten molecules in competitive immunoassay.

  13. Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2/TNFα

    Directory of Open Access Journals (Sweden)

    Hui-Ying Li

    2012-01-01

    Full Text Available This work is to study the baicalin and its three analogs, baicalin, wogonoside, and wogonin, on the protective effect of neuron from oxygen-glucose deprivation (OGD and toll-like receptor 2 (TLR2 expression in OGD damage. The results showed that baicalin and its three analogs did protect neurons from OGD damage and downregulated protein level of TLR2. D-Glucopyranosiduronic acid on site 7 in the structure played a core of cytotoxicity of these flavonoid analogs. The methoxyl group on carbon 8 of the structure had the relation with TLR2 protein expression, as well as the anti-inflammation. In addition, we detected caspase3 and antioxidation capability, to investigate the effect of four analogs on cell apoptosis and total antioxidation competence in OGD model.

  14. Conjecturing via Reconceived Classical Analogy

    Science.gov (United States)

    Lee, Kyeong-Hwa; Sriraman, Bharath

    2011-01-01

    Analogical reasoning is believed to be an efficient means of problem solving and construction of knowledge during the search for and the analysis of new mathematical objects. However, there is growing concern that despite everyday usage, learners are unable to transfer analogical reasoning to learning situations. This study aims at facilitating…

  15. Structural diagenesis in Upper Carboniferous tight gas sandstones. Lessons learned from the Piesberg analog study

    Energy Technology Data Exchange (ETDEWEB)

    Steindorf, P.; Hoehne, M.; Becker, S.; Hilgers, C. [RWTH Aachen Univ. (Germany). Energy and Mineral Resources Group (EMR); Koehrer, B. [Wintershall Holding GmbH, Barnstorf (Germany)

    2013-08-01

    unconventional reservoir properties at a subseismic scale, considering both the alteration and evolution of pore space during diagenesis and the formation of structures. Combined with well-log and core data, uncertainties in 3D-reservoir modeling parameters and fluid migration pathways from seismic- to micro-scale of analogous subsurface tight gas reservoirs may be significantly reduced. (orig.)

  16. Quality of sunglasses available in the Iranian market; a study with emphasis on sellers′ license

    Directory of Open Access Journals (Sweden)

    Nooshin Bazzazi

    2015-01-01

    Full Text Available Context: Sunglasses should follow minimum requirements to sufficiently protect eyes. It is not known whether all items obtainable from the market are appropriately designed. Aims: To compare ultraviolet (UV-protective properties of commercially available sunglasses obtained from authorized and unauthorized Iranian sellers. Settings and Study Design: An analytic-descriptive study performed in a metropolitan area (Tehran. Materials and Methods: Using a UV-visible standard spectrophotometer, the percentage transmittance was scanned between 280 and 400 nm in 348 pairs of nonprescription sunglasses (price range: 20-80 US$ obtained anonymously and randomly from authorized (permitted by the Ministry of Health, 189 pairs and unauthorized (159 pairs sellers in the Iranian capital city, Tehran. The Australian/New Zealand Standard (AS/NZS and the American National Standards Institute [ANSI] standards were followed. Statistical Analysis: Chi-square test, independent samples t-test or Mann-Whitney U-test. Results UV-protective properties of the sunglasses obtained from authorized sellers complied with AS/NZS and ANSI guidelines in 92.6% and 95.2% of items, respectively. The corresponding rates for sunglasses obtained from unauthorized sellers were 0% and 8.2%, respectively (P < 0.001 for both. The rate of defective polarizing capability of lenses was 27.4% in sunglasses obtained from authorized sellers versus 90.4% in sunglasses obtained from unauthorized sellers (P < 0.001. Neither brand nor price played significant contributions to UV protection/lens polarizing capability of sunglasses obtained from authorized sellers. Conclusions: Sunglasses provided by unauthorized sellers are alarmingly unreliable and could be potentially hazardous for the eye. Brand and price do not guarantee optimal protection against UV radiation or polarizing performance of the lens.

  17. Laboratory Studies of the Heterogeneous Uptake of Methane on Martian Soil Analogs: Determination of Upper Limits of Reactivity

    Science.gov (United States)

    Gough, R. V.; Hatch, C. D.; Tolbert, M. A.

    2007-12-01

    In order to constrain possible methane sources on Mars, it is necessary to understand the type and magnitude of all possible methane sinks. We have performed laboratory experiments to determine the importance of heterogeneous uptake of methane on mineral surfaces analogous to Martian surface material. The uptake of methane on sodium montmorillonite and Mars soil simulant JSC-1 (a palagonite) was studied using a Knusden cell flow reactor capable of achieving Martian temperature, pressure and relative humidity conditions. A quadrupole mass spectrometer was used to detect any decrease in methane flow due to heterogeneous uptake and infrared spectroscopy was used to detect any adsorbed species on the particles. Experiments were performed under Martian temperatures (from 195 to 215 K), and under both dry conditions and 45% RH. As montmorillonite clay possesses unique swelling properties in the presence of water vapor, experiments were performed in which the clay was simultaneously exposed to water and methane, and also experiments in which the clay was equilibrated with water vapor prior to methane exposure. We found no methane uptake relative to an unreactive blank Si wafer on any of the Martian soil analogs studied under any conditions. These negative results place upper limits on the heterogeneous reactivity of methane on the Martian surface. We have determined that the initial uptake coefficient of methane on palagonite is less than 3.66×10-10 (±1.41×10-11) and the initial uptake coefficient, γ0, of methane on montmorillonite is less than 7.52×10-10 (±2.56×10-11). These studies demonstrate methane uptake by mineral surfaces is not expected to be a significant methane sink, as the process likely occurs on a time scale much longer than photolysis.

  18. 9 CFR 107.2 - Products under State license.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Products under State license. 107.2 Section 107.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS EXEMPTIONS FROM...

  19. Data-mining to build a knowledge representation store for clinical decision support. Studies on curation and validation based on machine performance in multiple choice medical licensing examinations.

    Science.gov (United States)

    Robson, Barry; Boray, Srinidhi

    2016-06-01

    Extracting medical knowledge by structured data mining of many medical records and from unstructured data mining of natural language source text on the Internet will become increasingly important for clinical decision support. Output from these sources can be transformed into large numbers of elements of knowledge in a Knowledge Representation Store (KRS), here using the notation and to some extent the algebraic principles of the Q-UEL Web-based universal exchange and inference language described previously, rooted in Dirac notation from quantum mechanics and linguistic theory. In a KRS, semantic structures or statements about the world of interest to medicine are analogous to natural language sentences seen as formed from noun phrases separated by verbs, prepositions and other descriptions of relationships. A convenient method of testing and better curating these elements of knowledge is by having the computer use them to take the test of a multiple choice medical licensing examination. It is a venture which perhaps tells us almost as much about the reasoning of students and examiners as it does about the requirements for Artificial Intelligence as employed in clinical decision making. It emphasizes the role of context and of contextual probabilities as opposed to the more familiar intrinsic probabilities, and of a preliminary form of logic that we call presyllogistic reasoning.

  20. Insights from a Geophysical and Geomorphological Mars Analog Field Study at the Great Kobuk Sand Dunes, Northwestern Alaska

    Science.gov (United States)

    McGinnis, R. N.; Dinwiddie, C. L.; Stillman, D.; Bjella, K.; Hooper, D. M.; Grimm, R. E.

    2010-12-01

    Terrestrial dune systems are used as natural analogs to improve understanding of the processes by which planetary dunes form and evolve. Selected terrestrial analogs are often warm-climate dune fields devoid of frozen volatiles, but cold-climate dunes offer a better analog for polar dunes on Mars. The cold-climate Great Kobuk Sand Dunes (GKSD) of Kobuk Valley National Park, Alaska, are a high-latitude, slowly migrating analog for polar, inter- and intracrater dune fields on Mars. The 67°N latitude, 62 km2 GKSD consist of moderately well sorted, fine-grained sands deposited within the Kobuk River valley ~50 km north of the Arctic Circle and ~160 km inland from Kotzebue Sound. Winds at the GKSD are influenced significantly by complex surrounding topography, an influence that is similar to many high-latitude inter- and intracrater dune fields on Mars. Average annual temperature and precipitation at the GKSD are -5°C and 430 mm. The dune field is generally resistant to atmospheric forcing (wind) for a significant portion of the year because of snowcover, similar to the effect that seasonal CO2 and H2O frost mantling have on Martian polar dunes. The dune field, which ranges in elevation from 33 to 170 m above mean sea level, consists of sand sheets as well as climbing and reversing barchanoid, transverse, longitudinal, and star dunes. Several tributaries to the Kobuk River bound and dissect the GKSD, producing cutbank exposures and alcoves that reveal internal structure. We report results from our detailed geophysical and geomorphological site characterization field study, which was conducted near peak freeze conditions from March 15 through April 2, 2010. We used multifrequency ground-penetrating radar (25, 50, 100, 250, 500, 1000 MHz) and capacitively coupled resistivity methods to image the internal structure of representative dunes, and performed ground truthing using a sampling auger, natural exposures, and Real-Time Kinematic Differential GPS. Data from twenty

  1. LICENSE PLATE LOCALIZATION USING GABOR FILTERS AND NEURAL NETWORKS

    Directory of Open Access Journals (Sweden)

    Sami Ktata

    2013-01-01

    Full Text Available Vehicle License Plate Detection (LPD is an important step for the vehicle plate recognition which can be used in the intelligent transport systems. Many methods have been proposed for the detection of license plates based on: Mathematical morphology, Discrete Wavelet Transform, Hough Transform and others. In general, an LPR system includes four main parts: Vehicle image acquisition, license plate detection, character segmentation and character recognition. In this study, we present a robust method for extracting and detecting license plates, from simple images of Tunisian vehicles, based on Gabor filters and neural networks. The proposed method is designed to perform recognition of any kind of license plates under any environmental conditions.

  2. Treprostinil sodium (Remodulin), a prostacyclin analog, in the treatment of critical limb ischemia: open-label study.

    Science.gov (United States)

    Berman, Scott; Quick, Rhonda; Yoder, Pam; Voigt, Sonia; Strootman, Deborah; Wade, Michael

    2006-01-01

    The purpose of this study was to assess the safety of continuous subcutaneous therapy with treprostinil sodium (Remodulin), a prostacyclin analog, and its effect on ischemic rest pain and ischemic wound healing in subjects with critical limb ischemia (CLI) and no planned revascularization procedure. This was a 12-week, open-label, single-center pilot study enrolling 10 subjects (mean age 82.4 years) with Fontaine stage III to IV (Rutherford class 4-6) peripheral arterial disease and ankle brachial indices less than 0.55. The primary end point was safety, and the secondary end points were the effects of treatment on ischemic rest pain, limb salvage, and wound healing. There was a 62% reduction in mean worst rest pain and a 57% reduction in mean average rest pain at week 12, with most subjects using less pain medication. Three subjects experienced complete healing of their wounds. No subject developed a new wound during the trial. Treprostinil was generally well tolerated. Subcutaneous infusion-site pain was the most frequently reported side effect, with one subject withdrawing from the study as a result. Jaw pain was reported by two subjects. One subject experienced two serious adverse events considered unrelated to treprostinil (cholecystitis and congestive heart failure). This study demonstrates that chronic, continuous subcutaneous treprostinil is safe and can be useful in the treatment of ischemic pain and wounds in subjects with CLI. Future controlled studies are needed to evaluate these effects and determine appropriate patient selection.

  3. An Analog Study of First Language Dominance and Interference over Second Language

    Science.gov (United States)

    Houmanfar, R.; Hayes, L. J.; Herbst, S. A.

    2005-01-01

    The purpose of this study was to design a model for "first language" dominance over "second language" performance and the interference of one language over the other. Two sets of equivalence relations showing a common element (i.e., the reference) were established under different contextual conditions. One set ("first language") was over trained…

  4. Terrestrial Spaceflight Analogs: Antarctica

    Science.gov (United States)

    Crucian, Brian

    2013-01-01

    Alterations in immune cell distribution and function, circadian misalignment, stress and latent viral reactivation appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to those observed in Astronauts, either during or immediately following spaceflight. Others are unique to the Concordia analog. Based on some initial immune data and environmental conditions, Concordia winterover may be an appropriate analog for some flight-associated immune system changes and mission stress effects. An ongoing smaller control study at Neumayer III will address the influence of the hypoxic variable. Changes were observed in the peripheral blood leukocyte distribution consistent with immune mobilization, and similar to those observed during spaceflight. Alterations in cytokine production profiles were observed during winterover that are distinct from those observed during spaceflight, but potentially consistent with those observed during persistent hypobaric hypoxia. The reactivation of latent herpesviruses was observed during overwinter/isolation, that is consistently associated with dysregulation in immune function.

  5. Bisphenol A and its analogs induce morphological and biochemical alterations in human peripheral blood mononuclear cells (in vitro study).

    Science.gov (United States)

    Michałowicz, Jaromir; Mokra, Katarzyna; Bąk, Agata

    2015-10-01

    Few studies have addressed the cellular effects of bisphenol S (BPS) and bisphenol AF (BPAF) on cells, and no study has been conducted to analyze the mechanism of action of bisphenols in blood cells. In this study, the effect of bisphenol A (BPA), bisphenol F (BPF), BPS and BPAF on human peripheral blood mononuclear cells (PBMCs) was analyzed. It was shown that BPA, BPF and BPAF in particular, decreased cell viability, which was associated with depletion of intracellular ATP level and alterations in PBMCs size and granulation. Bisphenols enhanced ROS (including OH˙) formation, which led to damage to lipids and proteins in PBMCs. The most significant alterations in ROS level were induced by BPF, and particularly BPAF. Moreover, it was shown that BPAF most strongly provoked lipid peroxidation, while BPA and BPS caused the greatest damage to proteins. It may be concluded that BPA and its analogs were capable of inducing oxidative stress and damage in PBMCs in the concentrations ranging from 0.06 to 0.5 μM (0.02-0.1 μg/ml), which may be present in human blood as a result of environmental exposure. Although, most of bisphenols studied decreased cell viability, size and ATP level at higher concentrations, BPAF exhibited its cytotoxic potential at low concentrations ranging from 0.3 to 3 μM (0.1-1.0 μg/ml) that may correspond to concentrations in humans following occupational exposure.

  6. Product Licenses Database Application

    CERN Document Server

    Tonkovikj, Petar

    2016-01-01

    The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

  7. In Silico Analog Design for Terbinafine Against Trichophyton rubrum: A Preliminary Study.

    Science.gov (United States)

    Karumuri, Sudha; Singh, Puneet Kumar; Shukla, Pratyoosh

    2015-09-01

    The diseases caused by dermatophytes are common among several other infections which cause serious threat to human health. It is evident that enzyme squalene epoxidase is responsible for prolonged dermatophyte infection and it is appealing to note that this enzyme is also responsible for fatty acid synthesis in these groups of fungi. In the present study, terbinafine drug which targets enzyme squalene epoxidase has been explored to design its various novel analogues. The present study suggests that many more prominent drug analogues could be constituted which may be crucial towards designing new drug candidates. In the present study, we have designed a series of such analogues viz. [(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)(naphthalen-1-ylmethyl)amine, N-[8-({[(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)amino}methyl)naphthalen-1-yl]-2-(sulfoamino) acetamide, {[4-(dihydroxyamino)-8-({[(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)amino}methyl)naphthalen-1-yl]sulfanyl}methanol and (R)-{[4-({[(2E,6R)-6,7-dimethyloct-2-en-4-yn-1-yl](methyl)amino}methyl)-5-[(hydroxysulfamoyl)amino]naphthalen-1-yl]amino}sulfinic acid. Moreover, further by molecular docking approach the binding between enzyme and designed analogues was further analysed. The present preliminary report suggested a considerably good docking interaction score of -338.75 kcal/mol between terbinafine and squalene epoxidase from Trichophyton rubrum. This preliminary study implies that few designed candidate ligands can be effectual towards the activity of this enzyme and can play crucial role in pathogenesis control of T. rubrum.

  8. Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies.

    Science.gov (United States)

    Rateb, Heba S; Ahmed, Hany E A; Ahmed, Sahar; Ihmaid, Saleh; Afifi, Tarek H

    2016-01-01

    In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives (4a-i, 5a-f, and 6a-c) were synthesized, fully characterized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the discovery of nine compounds 4c, 4f, 4g, 4h, 4i, 5c, 5d, 5e, and 6c (MIC range from 0.49 to 31.5 μg/mL) with potent antibacterial, antifungal, and antimycobacterial activities. Ampicillin, ciprofloxacin, amphotericin B were used as references for antibacterial and antifungal screening respectively, while isoniazid was used as a reference for antimycobacterial testing. Furthermore, molecular modeling studies were done to explore the binding mode of the most active derivatives to M. tuberculosis enoyl reductase (InhA) and DNA gyrase B. Our study showed the importance of both hydrogen bonding and hydrophobic interactions as a key interaction with the target enzymes.

  9. Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies

    Science.gov (United States)

    Rateb, Heba S.; Ahmed, Hany E. A.; Ahmed, Sahar; Ihmaid, Saleh; Afifi, Tarek H

    2016-01-01

    In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives (4a-i, 5a-f, and 6a-c) were synthesized, fully characterized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the discovery of nine compounds 4c, 4f, 4g, 4h, 4i, 5c, 5d, 5e, and 6c (MIC range from 0.49 to 31.5 μg/mL) with potent antibacterial, antifungal, and antimycobacterial activities. Ampicillin, ciprofloxacin, amphotericin B were used as references for antibacterial and antifungal screening respectively, while isoniazid was used as a reference for antimycobacterial testing. Furthermore, molecular modeling studies were done to explore the binding mode of the most active derivatives to M. tuberculosis enoyl reductase (InhA) and DNA gyrase B. Our study showed the importance of both hydrogen bonding and hydrophobic interactions as a key interaction with the target enzymes.

  10. Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications.

    Science.gov (United States)

    Mo, Jiao; Guo, Yang; Yang, Yu-She; Shen, Jing-Shan; Jin, Guo-Zhang; Zhen, Xuechu

    2007-01-01

    Tetrahydroprotoberberines (THPBs) represent a series of compounds extracted from the Chinese herb Corydalis ambigua and various species of Stephania. THPBs, dependent on the presence of hydroxyl groups in its structure, are divided into three types: nonhydroxyl-THPBs, monohydroxyl-THPBs and dihydroxyl-THPBs. THPBs are identified as a new category of dopamine receptor ligands. Among all THPBs, dihydroxyl-THPBs attracted particular attention because of their dual actions on dopamine (DA) receptors. They exhibit D(1) receptor agonistic activity while acting as D(2) receptor antagonists. This unique pharmacological profile made dihydroxyl-THPBs such as l-stepholidine (l-SPD) potential agents in the treatment of drug addiction, Parkinson's disease, and especially, schizophrenia. Clinical studies have shown that co-administration of l-SPD with a typical antipsychotic drug significantly enhances the therapeutic effects and remarkably reduces the tardive dyskinesia induced by the typical antipsychotic drug used with schizophrenic patients. Moreover, l-SPD alone was shown to have therapeutic value without inducing significant extrapyramidal side effects and also seemed to reduce the negative symptoms of schizophrenia. This is confirmed in experimental studies using animal models of schizophrenia, in which l-SPD improved social interaction and cognitive function, inhibited hyperactivity in schizophrenic animals. This review discusses the chemistry, pharmacology and clinical implications of l-THPBs in the drug development for psychosis and neurobiological diseases.

  11. A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077.

    Science.gov (United States)

    Britten, C D; Rowinsky, E K; Baker, S D; Weiss, G R; Smith, L; Stephenson, J; Rothenberg, M; Smetzer, L; Cramer, J; Collins, W; Von Hoff, D D; Eckhardt, S G

    2000-01-01

    This Phase I study was performed to evaluate the tolerability and pharmacokinetic behavior of MKT-077, a water soluble rhodacyanine dye analogue, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. Thirteen patients with advanced solid malignancies were treated with MKT-077 administered as a 30-min i.v. infusion weekly for 4 weeks every 6 weeks at doses ranging from 42 to 126 mg/m2/week. The principal toxicity was renal magnesium wasting, which was dose-limiting (grade 3) in one patient at each of the 84- and 126-mg/m2 dose levels. The other three patients at the 126-mg/m2 dose level developed grade 2 hypomagnesemia, which was cumulative in nature, improved with i.v. magnesium supplementation, and was controlled in two patients by the administration of prophylactic magnesium before and after treatment with MKT-077. Given the requirement for extensive monitoring of serum magnesium levels, dose escalation >126 mg/m2 was not considered feasible. Thus, the recommended dose for disease-oriented studies with this schedule of MKT-077 is 126 mg/m2/week. Pharmacokinetic studies revealed a prolonged terminal half-life (37 +/- 17 h) and a large volume of distribution (685 +/- 430 liters/m2). Clearance averaged 39 +/- 13 liters/h/m2. Peak MKT-077 plasma concentrations (1.2 +/-0.31 to 6.3 +/- 5.3 microg/ml) exceeded the IC50 concentrations required for human CX-1 colon, MCF-breast, CRL-1420 pancreas, EJ bladder, and LOX melanoma tumor cell lines in vitro (0.15-0.5 microg/ml). These results indicate that at the recommended dose level of 126 mg/m2/week of MKT-077, the toxicity profile was consistent with the preferential accumulation of the agent within tumor cell mitochondria, and biologically relevant plasma concentrations were achieved.

  12. Analog Studies of Thermomechanical Fatigue and Abrasive Wear of Cast and Forged Steels for "Autoforge" Dies

    Science.gov (United States)

    Kolesnikov, M. S.; Mironova, Yu. S.; Mukhametzyanova, G. F.; Novikova, I. E.; Novikov, V. Yu.

    2014-07-01

    Processes of thermomechanical fatigue and abrasive wear of suspension-cast precipitation-hardening ferrite-carbide steel 30T6NTiC-1.5 and standard steel 4Kh5MFS are studied. The dominant kinds of fracture typical for dies for semisolid stamping are determined. The factors and parameters of cyclic temperature and force loading are shown to produce a selective action on the competing kinds of damage of the die steels. A comparative analysis of the properties of the steels is performed. Steel 30T6NTiC-1.5 is shown to have substantial advantages over steel 4Kh5FMS traditionally used for making "Autoforge" dies.

  13. Molecular modeling of fentanyl analogs

    Directory of Open Access Journals (Sweden)

    LJILJANA DOSEN-MICOVIC

    2004-11-01

    Full Text Available Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper.

  14. Design, synthesis, and docking studies of afatinib analogs bearing cinnamamide moiety as potent EGFR inhibitors.

    Science.gov (United States)

    Tu, Yuanbiao; OuYang, Yiqiang; Xu, Shan; Zhu, Yan; Li, Gen; Sun, Chao; Zheng, Pengwu; Zhu, Wufu

    2016-04-01

    Two series of afatinib derivatives bearing cinnamamide moiety (10a-n and 11a-h) were designed, synthesized and evaluated for the IC50 values against four cancer cell lines (A549, PC-3, MCF-7 and Hela). Two selected compounds (10e, 10k) were further evaluated for the inhibitory activity against EGFR and VEGFR2/KDR kinases. Seven of the compounds showed excellent cytotoxicity activity and selectivity with the IC50 values in single-digit μM to nanomole range. Three of them are equal to more active than positive control afatinib against one or more cell lines. The most promising compound 10k showed the best activity against A549, PC-3, MCF-7 and Hela cancer cell lines and EGFR kinase, with the IC50 values of 0.07 ± 0.02 μM, 7.67 ± 0.97 μM, 4.65 ± 0.90 μM and 4.83 ± 1.28 μM, which were equal to more active than afatinib (0.05 ± 0.01 μM, 4.1 ± 2.47 μM, 5.83 ± 1.89 μM and 6.81 ± 1.77 μM), respectively. Activity of compounds 10e (IC50 9.1 nM) and 10k (IC50 3.6 nM) against EGFR kinase were equal to the reference compound afatinib (IC50 1.6 nM). Structure-activity relationships (SARs) and docking studies indicated that replacement of the aqueous solubility 4-(dimethylamino)but-2-enamide group by cinnamamide moiety didn't decrease the antitumor activity. The results suggested that methoxy substitution had a significant impact on the activity and methoxy substituted on C-4 or C-2,3,4 position was benefit for the activity.

  15. Allegheny County Dog Licenses

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — A list of dog license dates, dog breeds, and dog name by zip code. Currently this dataset does not include City of Pittsburgh dogs.

  16. Learning by Analogy: Discriminating between Potential Analogs

    Science.gov (United States)

    Richland, Lindsey E.; McDonough, Ian M.

    2010-01-01

    The ability to successfully discriminate between multiple potentially relevant source analogs when solving new problems is crucial to proficiency in a mathematics domain. Experimental findings in two different mathematical contexts demonstrate that providing cues to support comparative reasoning during an initial instructional analogy, relative to…

  17. Mechanisms of Peptide Fragmentation from Time-and Energy-Resolved Surface-Induced Dissociation Studies: Dissociation of Angiotensin Analogs

    Energy Technology Data Exchange (ETDEWEB)

    Laskin, Julia; Bailey, Thomas H.; Futrell, Jean H.

    2006-03-01

    Energetics and mechanism of dissociation of singly protonated angiotensin III (RVYIHPF) and its analogs RVYIFPF, RVYIYPF, RVYIHAF, and RVYIHDF was studied using surface-induced dissociation (SID) in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially configured for studying ion activation by collisions with surfaces. The energetics and dynamics of peptide fragmentation were deduced by modeling the time- and energy-resolved survival curves for each precursor ion using an RRKM based approach developed in our laboratory. Fragmentation mechanisms were inferred from comparison of time- and energy-resolved fragmentation efficiency curves (TFECs) of different fragment ions followed by RRKM modeling of dissociation of angiotensin III into six major families of fragment ions. Detailed modeling demonstrated that dissociation of these peptides is dominated by loss of ammonia from the precursor ion and characterized by a high energy barrier of 1.6 eV. Loss of NH3 and subsequent rearrangement of the MH-NH3 ion results in proton mobilization and release of ca. 30 kcal/mol into internal excitation of the MH-NH3 ion. The resulting highly excited ion accesses a variety of non-specific dissociation pathways with very high rate constants. Fast fragmentation of excited MH-NH3 ion forms a variety of abundant bn-NH3 and an-NH3 fragment ions. Abundant XH and HX internal fragments are also formed, reflecting the stability of histidine-containing diketopiperazine structures.

  18. Mechanisms of peptide fragmentation from time- and energy-resolved surface-induced dissociation studies: Dissociation of angiotensin analogs

    Science.gov (United States)

    Laskin, Julia; Bailey, Thomas H.; Futrell, Jean H.

    2006-03-01

    Energetics and mechanism of dissociation of singly protonated angiotensin III (RVYIHPF) and its analogs RVYIFPF, RVYIYPF, RVYIHAF and RVYIHDF was studied using surface-induced dissociation (SID) in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially configured for studying ion activation by collisions with surfaces. The energetics and dynamics of peptide fragmentation were deduced by modeling the time- and energy-resolved survival curves for each precursor ion using an RRKM-based approach developed in our laboratory. Fragmentation mechanisms were inferred from comparison of time- and energy-resolved fragmentation efficiency curves (TFECs) of different fragment ions followed by RRKM modeling of dissociation of angiotensin III into six major families of fragment ions. Detailed modeling demonstrated that dissociation of these peptides is dominated by loss of ammonia from the precursor ion and characterized by a high-energy barrier of 1.6 eV. Loss of NH3 and subsequent rearrangement of the MH+-NH3 ion results in proton mobilization and release of ca. 30 kcal/mol into internal excitation of the MH+-NH3 ion. The resulting highly excited ion accesses a variety of non-specific dissociation pathways with very high rate constants. Fast fragmentation of excited MH+-NH3 ion forms a variety of abundant bn-NH3 and an-NH3 fragment ions. Abundant XH and HX internal fragments are also formed, reflecting the stability of histidine-containing diketopiperazine structures.

  19. Intuitive analog circuit design

    CERN Document Server

    Thompson, Marc

    2013-01-01

    Intuitive Analog Circuit Design outlines ways of thinking about analog circuits and systems that let you develop a feel for what a good, working analog circuit design should be. This book reflects author Marc Thompson's 30 years of experience designing analog and power electronics circuits and teaching graduate-level analog circuit design, and is the ideal reference for anyone who needs a straightforward introduction to the subject. In this book, Dr. Thompson describes intuitive and ""back-of-the-envelope"" techniques for designing and analyzing analog circuits, including transistor amplifi

  20. Libraries, licensing and the challenge of stewardship.

    OpenAIRE

    Farb, Sharon

    2006-01-01

    Stewardship has always figured predominantly in the mission of libraries. This paper discusses major findings and implications of a study of licensing in U.S. academic libraries. The data suggests that not all libraries are accepting their heritage role — that is, they are not planning for long–term preservation and access for their growing licensed digital collections and resources. Instead they rely increasingly on third parties to perform this fundamental function. This shift may have far–...

  1. Improving the Business Trade Licensing Reform Environment

    OpenAIRE

    Gamser, Matthew

    2003-01-01

    This case study of Kenyan business trade licensing shows that red-tape costs can be cut if reform is championed strongly and there is a strong case in terms of costs and benefits. The reform of business registration, trade licensing and other business entry procedures is a cost effective and progressive way to promote indigenous private sector development. But, reform needs more than good cost-benefit analysis and legal drafting; it also requires building constituencies and continuous advocacy.

  2. Studies toward the unique pederin family member psymberin: full structure elucidation, two alternative total syntheses, and analogs.

    Science.gov (United States)

    Feng, Yu; Jiang, Xin; De Brabander, Jef K

    2012-10-17

    Two synthetic approaches to psymberin have been accomplished. A highly convergent first generation synthesis led to the complete stereochemical assignment and demonstrated that psymberin and irciniastatin A are identical compounds. This synthesis featured a diastereoselective aldol coupling between the aryl fragment and a central tetrahydropyran core and a novel one-pot procedure to convert an amide, via intermediacy of a sensitive methyl imidate, to the N-acyl aminal reminiscent of psymberin. The highlights of the second generation synthesis include an efficient iridium-catalyzed enantioselective bisallylation of neopentyl glycol and a stepwise Sonogashira coupling/cycloisomerization/reduction sequence to construct the dihydroisocoumarin unit. The two synthetic avenues were achieved in 17-18 steps (longest linear sequence, ~14-15 isolations) from 3 fragments prepared in 7-8 (first generation) and 3-8 (second generation) steps each. This convergent approach allowed for the preparation of sufficient amounts of psymberin (~ 0.5 g) for follow-up biological studies. Meanwhile, our highly flexible strategy enabled the design and synthesis of multiple analogs, including a psymberin-pederin hybrid, termed psympederin, that proved crucial to a comprehensive understanding of the chemical biology of psymberin and related compounds that will be described in a subsequent manuscript.

  3. A comparison of acceptance- and control-based strategies for coping with food cravings: an analog study.

    Science.gov (United States)

    Forman, Evan M; Hoffman, Kimberly L; McGrath, Kathleen B; Herbert, James D; Brandsma, Lynn L; Lowe, Michael R

    2007-10-01

    The present study utilized an analog paradigm to investigate the effectiveness of two strategies for coping with food cravings, which was theorized to be critical to the maintenance of weight loss. Ninety-eight undergraduate students were given transparent boxes of chocolate Hershey's Kisses and instructed to keep the chocolates with them, but not to eat them, for 48 h. Before receiving the Kisses, participants were randomized to receive either (a) no intervention, (b) instruction in control-based coping strategies such as distraction and cognitive restructuring, or (c) instruction in acceptance-based strategies such as experiential acceptance and defusion techniques. Measures included the Power of Food Scale (PFS; a measure of psychological sensitivity to the food environment), self-report ratings of chocolate cravings and surreptitiously recorded chocolate consumption. Results suggested that the effect of the intervention depended on baseline PFS levels, such that acceptance-based strategies were associated with better outcomes (cravings, consumption) among those reporting the highest susceptibility to the presence of food, but greater cravings among those who scored lowest on the PFS. It was observed that craving self-report measures predicted chocolate consumption, and baseline PFS levels predicted both cravings and consumption. Results are discussed in terms of the implications for weight loss maintenance strategies.

  4. Determination of an organic-acid analog of DOC for use in copper toxicity studies on salmonids

    Energy Technology Data Exchange (ETDEWEB)

    MacRae, R.K.; Meyer, J.S.; Hansen, J.A.; Bergman, H.L. [Univ. of Wyoming, Laramie, WY (United States); Maest, A.; Marr, J.; Beltman, D.; Lipton, J. [Hagler Bailly, Inc., Boulder, CO (United States)

    1995-12-31

    Concentrations of dissolved copper in streams draining mine sites often exceed concentrations shown to cause acute and chronic mortality in salmonids. However, toxicity and impaired behaviors may be modified by dissolved organic carbon (DOC) and other inorganic components present in the site water. The effects of DOC on copper speciation, and thus bioavailability and toxicity, were determined by titrating stream waters with copper, using a cupric ion-specific electrode to detect free copper concentrations. Effects of various competing cations (e.g., Ca{sup +2}, Co{sup +2}) on copper-DOC binding were also evaluated. Titration results were evaluated using Scatchard and non-linear regression analyses to quantify the strength and capacity of copper-DOC binding. Inorganic speciation was determined using the geochemical model MINEQL{sup +}. Results of these titrations indicated the presence of two or three distinct copper binding components in site water DOC. Three commercially available organic acids where then chosen to mimic the binding characteristics of natural DOC. This DOC-analog was used successfully in fish toxicity studies to evaluate the influence of DOC on copper bioavailability. Geochemical models were developed to predict copper speciation in both laboratory test waters and site waters, for any typical combination of water chemistry parameters (pH, alkalinity, [DOC], etc.). A combined interpretation of fish toxicity and modeling results indicate that some DOC-bound copper was bioavailable.

  5. Fragmentation energetics for angiotensin II and its analogs from time- and energy-resolved surface-induced dissociation studies

    Science.gov (United States)

    Laskin, Julia; Bailey, Thomas H.; Futrell, Jean H.

    2004-05-01

    Surface-induced dissociation (SID) of four model peptides: DRVYIHPF, RVYIHPF, RVYIHAF, and RVYIHDF was studied using a novel Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially configured for SID experiments. The energetics and dynamics of peptide fragmentation were deduced by modeling the time- and energy-resolved survival curves for each precursor ion using an RRKM based approach developed in our laboratory. Accurate dissociation parameters can be obtained from these experiments because collision-energy-resolved SID data are very sensitive to both the energetics and dynamics of dissociation. We found that transition from selective to non-selective fragmentation as ion kinetic energy is increased is associated with a substantial (ca. 0.5 eV) increase in the dissociation energy and a 3-4 orders of magnitude increase in the pre-exponential factor. Dissociation thresholds for angiotensin analogs derived from the experimental data are as follows: 1.62 eV for RVYIHAF and RVYIHPF, 1.14 eV for RVYIHDF and 1.13 eV for DRVYIHPF. Pre-exponential factors of 8.2×1011, 7.2×1012, 3.1×108, and 5.0×107 s-1 were obtained for RVYIHPF, RVYIHAF, RVYIHDF, and DRVYIHPF, respectively. Contribution from shattering to the total decomposition of the precursor ion increases for kinetically hindered fragmentation. The largest contribution is observed for a peptide ion that has the largest negative reaction entropy--DRVYIHPF.

  6. 行政许可的外部性初探%Externally Study of the Administrative Licensing

    Institute of Scientific and Technical Information of China (English)

    杨学斌

    2012-01-01

    政府的行政许可行为同市场主体行为一样,都会产生大量的溢出效应,被称之为外部性。这种外部性的存在既不利于行政许可追求公共利益最大化的目标,也在一定程度上影响到了社会的公平,必须内部化。而征收类似庇古税等费用、明确产权、将更多行政许可的决策权交予民众、建立各地区间的利益协调机制是内部化的重要措施。%The action of administrative licensing of the government is the same as the behavior of market players,produces massive spillover effects,which called externality.The existence of the externality is not conducive to the pursuit of public benefit maximization,but also to some extent affects the social justice,it must be internalized.Collecting fees such as pigou tax,clearing property rights,giving more decision-making power of administrative licensing to citizens,and setting up interests of the coordination mechanism the across regions are the important measures of internalization.

  7. Interpretation of surface properties of comet 67P/Churyumov-Gerasimenko using bidirectional reflectance studies of laboratory cometary analogs

    Science.gov (United States)

    Jost, Bernhard; Pommerol, Antoine; Poch, Olivier; Fornasier, Sonia; Hasselmann, Pedro Henrique; Feller, Clément; Carrasco, Nathalie; Szopa, Cyril; Thomas, Nicolas

    2016-10-01

    The European Space Agency's Rosetta mission has been orbiting the nucleus of comet 67P/Churyumov-Gerasimenko (67P) for more than 2 years. An enormous quantity of surface data at variable spatial resolution and over a wide range of the electromagnetic spectrum has been acquired by a series of complementary instruments during this period. The long accompany time allowed characterization and comparison of spectrophotometric properties in the pre- and post-perihelion phase.A profound knowledge of laboratory analogues of cometary surfaces is essential for interpreting remote sensing data. The LOSSy laboratory (Laboratory for Outflow Studies of Sublimating Materials) at the University of Bern was set up to study the spectrophotometric properties of ice-bearing cometary nucleus analogs. The laboratory is equipped with two instruments: the PHIRE-2 radio-goniometer [2], designed to measure the bidirectional visible reflectance of samples under a wide range of geometries and the SCITEAS simulation chamber [3], designed to study the evolution of icy samples subliming under low pressure/temperature conditions by hyperspectral imaging in the VIS-NIR range.We present reflectance data of various well characterized and reproducible mixtures of fine grained ice particles, tholins, and carbonaceous compounds that we systematically compare to the phase curves, albedo, spectrum and phase reddening observed by Rosetta at 67P [4].Our results allow us setting a lower limit of a few micrometers on the dust particle size and demonstrate that meter-sized bright patches have to be relatively dust free at small scale. Further we show that the most porous samples (p≈80%) best match the phase curve of 67P.[1] Keller, H. U., et al., 2007, Space Sci. Rev. 128, 26[2] Jost, B., et al., 2016. Icarus 264, 109-131.[3] Pommerol, A., et al., 2015. Planet Space Sci 109, 106-122.[4] Fornasier, S., et al., 2015. A&A 583, A30.

  8. A meta-analytic review of moral licensing.

    Science.gov (United States)

    Blanken, Irene; van de Ven, Niels; Zeelenberg, Marcel

    2015-04-01

    Moral licensing refers to the effect that when people initially behave in a moral way, they are later more likely to display behaviors that are immoral, unethical, or otherwise problematic. We provide a state-of-the-art overview of moral licensing by conducting a meta-analysis of 91 studies (7,397 participants) that compare a licensing condition with a control condition. Based on this analysis, the magnitude of the moral licensing effect is estimated to be a Cohen's d of 0.31. We tested potential moderators and found that published studies tend to have larger moral licensing effects than unpublished studies. We found no empirical evidence for other moderators that were theorized to be of importance. The effect size estimate implies that studies require many more participants to draw solid conclusions about moral licensing and its possible moderators.

  9. Volcanic settings and their reservoir potential: An outcrop analog study on the Miocene Tepoztlán Formation, Central Mexico

    Science.gov (United States)

    Lenhardt, Nils; Götz, Annette E.

    2011-07-01

    The reservoir potential of volcanic and associated sedimentary rocks is less documented in regard to groundwater resources, and oil and gas storage compared to siliciclastic and carbonate systems. Outcrop analog studies within a volcanic setting enable to identify spatio-temporal architectural elements and geometric features of different rock units and their petrophysical properties such as porosity and permeability, which are important information for reservoir characterization. Despite the wide distribution of volcanic rocks in Mexico, their reservoir potential has been little studied in the past. In the Valley of Mexico, situated 4000 m above the Neogene volcanic rocks, groundwater is a matter of major importance as more than 20 million people and 42% of the industrial capacity of the Mexican nation depend on it for most of their water supply. Here, we present porosity and permeability data of 108 rock samples representing five different lithofacies types of the Miocene Tepoztlán Formation. This 800 m thick formation mainly consists of pyroclastic rocks, mass flow and fluvial deposits and is part of the southern Transmexican Volcanic Belt, cropping out south of the Valley of Mexico and within the two states of Morelos and Mexico State. Porosities range from 1.4% to 56.7%; average porosity is 24.8%. Generally, permeabilities are low to median (0.2-933.3 mD) with an average permeability of 88.5 mD. The lavas are characterized by the highest porosity values followed by tuffs, conglomerates, sandstones and tuffaceous breccias. On the contrary, the highest permeabilities can be found in the conglomerates, followed by tuffs, tuffaceous breccias, sandstones and lavas. The knowledge of these petrophysical rock properties provides important information on the reservoir potential of volcanic settings to be integrated to 3D subsurface models.

  10. Structured Analog CMOS Design

    CERN Document Server

    Stefanovic, Danica

    2008-01-01

    Structured Analog CMOS Design describes a structured analog design approach that makes it possible to simplify complex analog design problems and develop a design strategy that can be used for the design of large number of analog cells. It intentionally avoids treating the analog design as a mathematical problem, developing a design procedure based on the understanding of device physics and approximations that give insight into parameter interdependences. The proposed transistor-level design procedure is based on the EKV modeling approach and relies on the device inversion level as a fundament

  11. Analog and hybrid computing

    CERN Document Server

    Hyndman, D E

    2013-01-01

    Analog and Hybrid Computing focuses on the operations of analog and hybrid computers. The book first outlines the history of computing devices that influenced the creation of analog and digital computers. The types of problems to be solved on computers, computing systems, and digital computers are discussed. The text looks at the theory and operation of electronic analog computers, including linear and non-linear computing units and use of analog computers as operational amplifiers. The monograph examines the preparation of problems to be deciphered on computers. Flow diagrams, methods of ampl

  12. Implementing a Public Health Objective for Alcohol Premises Licensing in Scotland: A Qualitative Study of Strategies, Values, and Perceptions of Evidence

    Science.gov (United States)

    Fitzgerald, Niamh; Nicholls, James; Winterbottom, Jo; Katikireddi, Srinivasa Vittal

    2017-01-01

    The public health objective for alcohol premises licensing, established in Scotland in 2005, is unique globally. We explored how public health practitioners engaged with the licensing system following this change, and what helped or hindered their efforts. Semi-structured interviews were conducted with 13 public health actors, audio-recorded, and analysed using an inductive framework approach. Many interviewees viewed the new objective as synonymous with reducing population-level alcohol consumption; however, this view was not always shared by licensing actors, some of whom did not accept public health as a legitimate goal of licensing, or prioritised economic development instead. Some interviewees were surprised that the public health evidence they presented to licensing boards did not result in their hoped-for outcomes; they reported that licensing officials did not always understand or value health data or statistical evidence. While some tried to give “impartial” advice to licensing boards, this was not always easy; others were clear that their role was one of “winning hearts and minds” through relationship-building with licensing actors over time. Notwithstanding the introduction of the public health objective, there remain significant, and political, challenges in orienting local premises licensing boards towards decisions to reduce the availability of alcohol in Scotland. PMID:28241512

  13. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  14. Attempted Isolation, Spectroscopic Characterization, and Computational Study of Diazirinone (N2CO), its Analogs, and their Precursors

    Science.gov (United States)

    Esselman, Brian J.; Nolan, Alex M.; Amberger, Brent K.; Shaffer, Chris J.; Woods, R. Claude; Stanton, John F.; McMahon, Robert J.

    2010-11-01

    Intrigued by the 2005 reported synthesis of diazirinone, we carried out further experimental and theoretical studies aimed at the detailed matrix-isolation and millimeter-wave spectroscopic characterizations. Diazirinone is a peculiar isoconjugate of two very stable molecules, CO and N2, which may be of astrochemical interest. Unfortunately, the previous reported methods of diazirinone generation did not yield this species, but rather its decomposition products. Encouraged by the many computational studies of the N2CO potential energy surface that all found diazirinone to be the lowest energy isomer, save its decomposition products, we proposed a new method of preparation of diazirinone from the photolysis or thermolysis of carbonyl diazide by loss of two nitrogen molecules. We were able to generate the highly explosive carbonyl diazide in sufficient yield from the reaction of triphosgene and sodium azide. This has allowed us to obtain a matrix-isolation and gas phase IR spectrum of carbonyl diazide which has a gas-phase lifetime of several days. We are currently engaged in the safe purification and distillation of our sample and obtaining a millimeter-wave spectrum of carbonyl diazide. We will attempt to photolyze or thermolyze this molecule to release diazirinone and characterize it by millimeter-wave spectroscopy to pave the way for possible astrochemical detection. In order to provide better mechanistic insight into the decomposition of carbonyl diazide to diazirinone, we have engaged in a DFT and ab initio computational study of several possible pathways. Our preliminary results suggest that of the pathways studied, a step-wise process in which an acyclic CON4 species is generated by loss of nitrogen followed by possible rearrangement and further loss of N2 is most likely. These results will be compared to the analogous reactions for azirinone (HC2NO), our next likely synthetic and spectroscopic target. The millimeter-wave absorption spectrometer used in this

  15. 47 CFR 13.17 - Replacement license.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.17 Replacement... Operator License, Marine Radio Operator Permit, First Class Radiotelegraph Operator's Certificate, Second... Radio Operator's License, Restricted GMDSS Radio Operator License, GMDSS Radio Maintainer's License,...

  16. 42 CFR 431.703 - Licensing requirement.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION State Programs for Licensing Nursing Home Administrators § 431.703 Licensing requirement. The State licensing program must provide that only nursing homes supervised by an administrator licensed in accordance with...

  17. License plate detection algorithm

    Science.gov (United States)

    Broitman, Michael; Klopovsky, Yuri; Silinskis, Normunds

    2013-12-01

    A novel algorithm for vehicle license plates localization is proposed. The algorithm is based on pixel intensity transition gradient analysis. Near to 2500 natural-scene gray-level vehicle images of different backgrounds and ambient illumination was tested. The best set of algorithm's parameters produces detection rate up to 0.94. Taking into account abnormal camera location during our tests and therefore geometrical distortion and troubles from trees this result could be considered as passable. Correlation between source data, such as license Plate dimensions and texture, cameras location and others, and parameters of algorithm were also defined.

  18. Digital Content Licensing

    DEFF Research Database (Denmark)

    Schwemer, Sebastian Felix

    -legislative) initiatives, which support the facilitation of multi-territorial licensing and cross-border access to content. It investigates the regulation of two online markets, which have recently been subject to scrutiny by the EU institutions: the audiovisual and the music sector, both addressed by ex ante sector...... and to enable cross-border access, and furthermore that the regulatory interventions to date may have been more driven by a competition and subsidiary a harmonisation agenda than a focus on the consumers and innovative service providers. Keywords: copyright licensing, cross-border access, sector...

  19. Structure-activity relationship studies of N-sulfonyl analogs of cocaine: role of ionic interaction in cocaine binding.

    Science.gov (United States)

    Kozikowski, A P; Saiah, M K; Bergmann, J S; Johnson, K M

    1994-09-30

    Six new N-sulfonylated analogs of cocaine have been prepared, and these compounds have been evaluated for their ability to inhibit [3H]mazindol binding and [3H]dopamine uptake into striatal synaptosomes. The N-sulfonyl compounds still inhibited binding and uptake at low micromolar concentrations despite the neutral character of the tropane nitrogen, thus suggesting that the binding of cocaine to the dopamine transporter may not require protonation of its nitrogen and ionic interaction with its recognition site.

  20. Oral prostacycline analog and clopidogrel combination provides early maturation and long-term survival after arteriovenous fistula creation: A randomized controlled study.

    Science.gov (United States)

    Abacilar, A F; Atalay, H; Dogan, O F

    2015-01-01

    Vascular access is used as a lifeline for hemodialysis in patients with end stage renal disease failure (ESRD). Failure of arteriovenous fistula (AVF) maturation is still high. The purpose of this study was to research the effects of clopidogrel in combination with oral iloprost, a synthetic analog of prostacyclin PGI2. Ninety-six diabetic ESRD patients were divided into two groups. In the first group (Group 1, N = 50), clopidogrel (75 mg daily dose) and an oral prostacycline analog (200 mg daily dose) were administered. In the second group (Group 2, N = 46), placebo was given. All patients took study medication 7-10 days prior to surgery. A Doppler ultrasound (USG) was performed for measurement of arterial and venous diameters, and peak systolic velocity of arterial flow based on subsequent fistula adequacy. Autogenous AVFs were constructed in forearm as distally as possible in all patients. Both groups were followed-up for a year. In the placebo group, early AVF thrombosis was detected in two patients (4.3%). AVF maturation failure was noted in 14 patients (30.4%) in placebo group and in four patients (8%) in clopidogrel plus oral prostacycline analog group in the early postoperative period (P = 0.001). The mean maturation time was 38 ± 6.5 and 53 ± 12.8 days in study and placebo groups, respectively (P = 0.023). The mean blood flow was 352 ± 94 mL/min in placebo group and 604 ± 125 mL/min in study group (P = 0.001). The arterial end diastolic velocity was 116 ± 14 cm/s in study group and 72 ± 21 cm/s in placebo group (P = 0.036) 1 year after the surgery. Our data indicated that clopidogrel and oral prostacycline analog combination is effective and safe for the prevention of primary AVF failure in hemodialysis patients and decreased acute and chronic thrombotic events.

  1. A License To Deal.

    Science.gov (United States)

    Sanville, Tom

    1999-01-01

    Discusses consortium-based licensing as a means of meeting libraries' information resources needs. Topics include information needs, the need for more affordable information, requirements for libraries and for vendors, competition across disciplines, saving money, pricing and market practices, experiences at OhioLINK, and future possibilities.…

  2. Analogy-Enhanced Instruction: Effects on Reasoning Skills in Science

    Science.gov (United States)

    Remigio, Krisette B.; Yangco, Rosanelia T.; Espinosa, Allen A.

    2014-01-01

    The study examined the reasoning skills of first year high school students after learning general science concepts through analogies. Two intact heterogeneous sections were randomly assigned to Analogy-Enhanced Instruction (AEI) group and Non Analogy-Enhanced (NAEI) group. Various analogies were incorporated in the lessons of the AEI group for…

  3. Analogy in CLAM

    OpenAIRE

    Melis, Erica

    1999-01-01

    CL A M is a proof planner, developed by the Dream group in Edinburgh,that mainly operates for inductive proofs. This paper addresses the questionhow an analogy model that I developed independently of CL A M can beapplied to CL A M and it presents analogy-driven proof plan construction as acontrol strategy of CL A M . This strategy is realized as a derivational analogythat includes the reformulation of proof plans. The analogical replay checkswhether the reformulated justifications of the sour...

  4. Analog circuit design

    CERN Document Server

    Dobkin, Bob

    2012-01-01

    Analog circuit and system design today is more essential than ever before. With the growth of digital systems, wireless communications, complex industrial and automotive systems, designers are being challenged to develop sophisticated analog solutions. This comprehensive source book of circuit design solutions aids engineers with elegant and practical design techniques that focus on common analog challenges. The book's in-depth application examples provide insight into circuit design and application solutions that you can apply in today's demanding designs. <

  5. Analogies of Information Security

    OpenAIRE

    Sole, Amund Bauck

    2016-01-01

    In this thesis it will be tested wither analogies and metaphors would make it easier to teach the fundamental subjects of information security and hacking to people with no previous background in computer science and only basic computer skills. This will be done by conducting interview on people with no background in computer science to see what analogies work the best for different topics in information security. From the analogy getting the best response, a small game will be designed with ...

  6. The ESA-NASA CHOICE Study: Winterover at Concordia Station, Interior Antarctica, A Potential Analog for Spaceflight-Associated Immune Dysregulation

    Science.gov (United States)

    Crucian, B. E.; Stowe, R. P.; Mehta, S. K.; Quiriarte, H.; Pierson, D L.; Sams, C. F.

    2010-01-01

    For ground-based space physiological research, the choice of terrestrial analog must carefully match the system of interest. Antarctica winter-over at the European Concordia Station is potentially a superior ground-analog for spaceflight-associated immune dysregulation (SAID). Concordia missions consist of prolonged durations in an extreme/dangerous environment, station-based habitation, isolation, disrupted circadian rhythms and international crews. The ESA-NASA CHOICE study assesses innate and adaptive immunity, viral reactivation and stress factors during Concordia winterover deployment. Initial data obtained from the first study deployment (2009 mission; 'n' of 6) will be presented, and logistical challenges regarding analog usage for biological studies will also be discussed. The total WBC increased, and alterations in some peripheral leukocyte populations were observed during winterover at Concordia Station. Percentages of lymphocytes and monocytes increased, and levels of senescent CD8+ T cells were increased during deployment. Transient increases in constitutively activated T cell subsets were observed, at mission time points associated with endemic disease outbreaks. T cell function (early blastogenesis response) was increased near the entry/exit deployment phases, and production of most measured cytokines increased during deployment. Salivary cortisol demonstrated high variability during winterover, but was generally increased. A 2-point circadian rhythm of cortisol measurement (morning/evening) was unaltered during winterover. Perceived stress was mildly elevated during winterover. Other measures, including in-vitro DTH assessment, viral specific T cell number/function and latent herpesvirus reactivation have not yet been completed for the 2009 winterover subjects. Based on the preliminary data, alterations in immune cell distribution and function appear to persist during Antarctic winterover at Concordia Station. Some of these changes are similar to

  7. To License or Not to License Revisited: An Examination of State Statutes Regarding Private Investigators and Digital Examiners

    Directory of Open Access Journals (Sweden)

    Thomas Lonardo

    2009-09-01

    Full Text Available In this update to the previous year's study, the authors examine statutes that regulate, license, and enforce investigative functions in each US state. After identification and review of Private Investigator licensing requirements, the authors find that very few state statutes explicitly differentiate between Private Investigators and Digital Examiners. After contacting all state agencies the authors present a distinct grouping organizing state approaches to professional Digital Examiner licensing. The authors conclude that states must differentiate between Private Investigator and Digital Examiner licensing requirements and oversight.

  8. The ESA-NASA 'CHOICE' Study: Winterover at Concordia Station, Interior Antarctica, as an Analog for Spaceflight-Associated Immune Dysregu1ation

    Science.gov (United States)

    Crucian, Brian E,; Feuerecker, M.; Salam, A. P.; Rybka, A.; Stowe, R. P.; Morrels, M.; Mehta, S. K.; Quiriarte, H.; Quintens, Roel; Thieme, U.; Kaufmann, I.; Baatout, D. S.; Pierson, D. L.; Sams, C. F.; Chouker, A.

    2011-01-01

    For ground-based space physiological research, the choice of analog must carefully match the system of interest. Antarctica winter-over at the European Concordia Station is potentially a ground-analog for spaceflight-associated immune dysregulation (SAID). Concordia missions consist of prolonged durations in an extreme/dangerous environment, station-based habitation, isolation, disrupted circadian rhythms and international crews. The ESA-NASA CHOICE study assess innate and adaptive immunity, viral reactivataion and stress factors during Concordia winter-over deployment. To date, not all samples have been analyzed. Here, only data will be preliminary presented for those parameters where sample/data analysis is completed (i.e., Leukocyte subsets, T cell function, and intracellular/secreted cytokine profiles.)

  9. Challenges in Using Analogies

    Science.gov (United States)

    Lin, Shih-Yin; Singh, Chandralekha

    2011-01-01

    Learning physics requires understanding the applicability of fundamental principles in a variety of contexts that share deep features. One way to help students learn physics is via analogical reasoning. Students can be taught to make an analogy between situations that are more familiar or easier to understand and another situation where the same…

  10. Hydraulic Capacitor Analogy

    Science.gov (United States)

    Baser, Mustafa

    2007-01-01

    Students have difficulties in physics because of the abstract nature of concepts and principles. One of the effective methods for overcoming students' difficulties is the use of analogies to visualize abstract concepts to promote conceptual understanding. According to Iding, analogies are consistent with the tenets of constructivist learning…

  11. Natural analogs in the host rock salt. Pt. 1. General study (2011). Pt. 2. Detail studies (2012-2013); Natuerliche Analoga im Wirtsgestein Salz. T. 1. Generelle Studie (2011). T. 2. Detailstudien (2012-2013)

    Energy Technology Data Exchange (ETDEWEB)

    Brasser, Thomas; Fahrenholz, Christine; Kull, Herbert; Meleshyn, Artur; Moenig, Heike; Noseck, Ulrich; Schoenwiese, Dagmar; Wolf, Jens

    2014-12-15

    The first part of the project ISIBELII on natural analogs in the host rock salt included a summary of available studies on the topic to be used in a safety analysis for a final repository for heat generating radioactive waste. In 2012 the results of the preliminary safety analysis Gorleben was available, including results on the fracturing of anhydrite, the formation of cryogenic gaps and the influence of earthquakes. The requirements for the barrier system have been modified due to the safety requirements for the final disposal of heat-generating radioactive wastes valid since 2010. For containers the functionality gas to be demonstrated for 500 years. The following issues are covered: natural analogs for the integrity demonstration of the geological barrier, natural analogs for the integrity demonstration of geotechnical barriers, natural analogs for the evaluation of release scenarios. The detail studies include anhydrite fracturing, salt grit compaction, chemical composition of fluid inclusions, thermal stability of salt rock, mechanical stability of salt rock, influence of earthquakes, qualified closures, iron corrosion, and microbial processes.

  12. License to Learn

    DEFF Research Database (Denmark)

    Leone, Maria Isabella; Boccardelli, Paolo; Reichstein, Toke;

    2016-01-01

    This article introduces the distinction between thin and thick contracts to the investigation of licensing-in as a mechanism for technological learning. Thick contracts include a clause specifying that the licensors are obligated to assist the licensees in assimilating and integrating....... Licensees that are more familiar with the licensed technology are in less need of assistance from the licensors to assimilate and integrate the knowledge. However, this substitution effect is neutralized once the hurdle of invention has been overcome, meaning that the licensees have succeeded to ignite...... the technology. Drawing on a sample of 133 licensees and an equal number of matched nonlicensees, we present empirical evidence that thick contracts propel the licensees' likelihood of introducing new inventions. It is also found that thick contracts act as a substitute for licensees' absorptive capacity...

  13. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.

    Science.gov (United States)

    Kumar, Vidya P; Cisneros, Jose A; Frey, Kathleen M; Castellanos-Gonzalez, Alejandro; Wang, Yiqiang; Gangjee, Aleem; White, A Clinton; Jorgensen, William L; Anderson, Karen S

    2014-09-01

    Cryptosporidium is the causative agent of a gastrointestinal disease, cryptosporidiosis, which is often fatal in immunocompromised individuals and children. Thymidylate synthase (TS) and dihydrofolate reductase (DHFR) are essential enzymes in the folate biosynthesis pathway and are well established as drug targets in cancer, bacterial infections, and malaria. Cryptosporidium hominis has a bifunctional thymidylate synthase and dihydrofolate reductase enzyme, compared to separate enzymes in the host. We evaluated lead compound 1 from a novel series of antifolates, 2-amino-4-oxo-5-substituted pyrrolo[2,3-d]pyrimidines as an inhibitor of Cryptosporidium hominis thymidylate synthase with selectivity over the human enzyme. Complementing the enzyme inhibition compound 1 also has anti-cryptosporidial activity in cell culture. A crystal structure with compound 1 bound to the TS active site is discussed in terms of several van der Waals, hydrophobic and hydrogen bond interactions with the protein residues and the substrate analog 5-fluorodeoxyuridine monophosphate (TS), cofactor NADPH and inhibitor methotrexate (DHFR). Another crystal structure in complex with compound 1 bound in both the TS and DHFR active sites is also reported here. The crystal structures provide clues for analog design and for the design of ChTS-DHFR specific inhibitors.

  14. Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor

    Directory of Open Access Journals (Sweden)

    Chean Hui Ng

    2014-08-01

    Full Text Available The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides. The search for selective LOX inhibitors may provide new therapeutic approach for inflammatory diseases. Herein, we report the synthesis of tHGA analogs using simple Friedel-Craft acylation and alkylation reactions with the aim of obtaining a better insight into the structure-activity relationships of the compounds. All the synthesized analogs showed potent soybean 15-LOX inhibitory activity in a dose-dependent manner (IC50 = 10.31–27.61 μM where compound 3e was two-fold more active than tHGA. Molecular docking was then applied to reveal the important binding interactions of compound 3e in soybean 15-LOX binding site. The findings suggest that the presence of longer acyl bearing aliphatic chain (5Cs and aromatic groups could significantly affect the enzymatic activity.

  15. Commitment of Licensed Social Workers to Aging Practice

    Science.gov (United States)

    Simons, Kelsey; Bonifas, Robin; Gammonley, Denise

    2011-01-01

    This study sought to identify client, professional, and employment characteristics that enhance licensed social workers' commitment to aging practice. A series of binary logistic regressions were performed using data from 181 licensed, full-time social workers who reported aging as their primary specialty area as part of the 2004 NASW's national…

  16. Troubleshooting analog circuits

    CERN Document Server

    Pease, Robert A

    1991-01-01

    Troubleshooting Analog Circuits is a guidebook for solving product or process related problems in analog circuits. The book also provides advice in selecting equipment, preventing problems, and general tips. The coverage of the book includes the philosophy of troubleshooting; the modes of failure of various components; and preventive measures. The text also deals with the active components of analog circuits, including diodes and rectifiers, optically coupled devices, solar cells, and batteries. The book will be of great use to both students and practitioners of electronics engineering. Other

  17. Technology Licensing and Firm Innovation

    DEFF Research Database (Denmark)

    Moreira, Solon

    that facilitate or constrain firms' ability to deal with licensed-in technologies have received little attention. This paper starts investigating in a longitudinal setting the effect of technology licensing on the number of patents produced by the licensee within the three years subsequent to the technology...... acquisition. The findings indicate that technology licensing is positively related to the number of inventions produced by the licensee in the years subsequent to the licensing deal. Subsequently, I investigate the moderating effect that organizational slack and myopia have on this main relationship....... The findings also suggest that high levels of Organizational Slack (available financial resources) strengthen the positive effect of licensing on innovation. However, higher levels of Organizational Myopia (the extent to which a firm draws on its own knowledge) can decrease the main effect of licensing....

  18. 47 CFR 78.29 - License period.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false License period. 78.29 Section 78.29... SERVICE Applications and Licenses § 78.29 License period. Licenses for CARS stations will be issued for a period not to exceed five (5) years. On and after February 1, 1966, licenses for CARS stations...

  19. 7 CFR 6.33 - License fee.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false License fee. 6.33 Section 6.33 Agriculture Office of... License fee. (a) A fee will be assessed each quota year for each license to defray the Department's costs... preceding the quota year for which the fee is assessed. (b) The license fee for each license issued is...

  20. 47 CFR 5.71 - License period.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false License period. 5.71 Section 5.71...) Applications and Licenses § 5.71 License period. (a) The regular license period for stations in the Experimental Radio Service is either 2 or 5 years. An applicant desiring to apply for a 5-year license...

  1. 47 CFR 1.945 - License grants.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false License grants. 1.945 Section 1.945... Applications and Proceedings Application Requirements and Procedures § 1.945 License grants. (a) License grants—auctionable license applications. Procedures for grant of licenses that are subject to competitive...

  2. Analog multivariate counting analyzers

    CERN Document Server

    Nikitin, A V; Armstrong, T P

    2003-01-01

    Characterizing rates of occurrence of various features of a signal is of great importance in numerous types of physical measurements. Such signal features can be defined as certain discrete coincidence events, e.g. crossings of a signal with a given threshold, or occurrence of extrema of a certain amplitude. We describe measuring rates of such events by means of analog multivariate counting analyzers. Given a continuous scalar or multicomponent (vector) input signal, an analog counting analyzer outputs a continuous signal with the instantaneous magnitude equal to the rate of occurrence of certain coincidence events. The analog nature of the proposed analyzers allows us to reformulate many problems of the traditional counting measurements, and cast them in a form which is readily addressed by methods of differential calculus rather than by algebraic or logical means of digital signal processing. Analog counting analyzers can be easily implemented in discrete or integrated electronic circuits, do not suffer fro...

  3. Challenges in Analogical Reasoning

    CERN Document Server

    Lin, Shih-Yin

    2016-01-01

    Learning physics requires understanding the applicability of fundamental principles in a variety of contexts that share deep features. One way to help students learn physics is via analogical reasoning. Students can be taught to make an analogy between situations that are more familiar or easier to understand and another situation where the same physics principle is involved but that is more difficult to handle. Here, we examine introductory physics students' ability to use analogies in solving problems involving Newton's second law. Students enrolled in an algebra-based introductory physics course were given a solved problem involving tension in a rope and were then asked to solve another problem for which the physics is very similar but involved a frictional force. They were asked to point out the similarities between the two problems and then use the analogy to solve the friction problem.

  4. FCC Universal Licensing System (ULS)

    Data.gov (United States)

    Federal Communications Commission — The Universal Licensing System allows electronic filing of applications processed by the Commission. The ULS allows you to indicate the application purpose and radio...

  5. Archaeological analogous and industrials for deep storage: study of the archaeological metallic piece; Analogos arqueologicos e industriales para almacenamientos profundos: estudio de piezas arqueologicas metalicas

    Energy Technology Data Exchange (ETDEWEB)

    Criado Portal, A. J.; Martinez Garcia, J. A.; Calabres Molina, R.; Garcia abajo, A.; Penco Valenzuela, F.; Lecanda Esteban, J. A.; Garcia Bartual, M.; Jimenez Gonzalez, J. M.; Bravo Munoz, E.; Rodriguez Lobo, L. M.; Fernandez Cascos, T.; Fernandes Cordero, O.; Montero Ruiz, I.

    2000-07-01

    The aim of present research is to obtain information about archaeological analogous of iron and steel, useful for the model of deep geological repository (AGP). The analogous examined have remained buried between 1400 and 2400 years, in very assorted geochemical environments. The extraction of the archaeological pieces has been accomplished according to normalised protocols, trying to carry to the laboratory so the piece as its burial environment, avoiding all possible pollution. Trying to the archaeological analogous could provide valuable information to the AGP model, the study has been directed to related the physical-chemical characteristics of the terrain respect to the deterioration of the archaeological metallic piece. The geology of the surrounding terrain to the archaeological deposit, the geomorphological study of the terrain and data from the analysis of ground: pH, wetness, porosity, organic matter contents, bacteria presence, sulphates, carbonates, chlorides, etc., have allowed to explain the physical-chemical phenomena suffered by the archaeological iron and steel pieces. Also, an exhaustive study of the archaeological piece has been accomplished, concerning the microstructure of the corrosion layer and of the not deteriorated metallic rest. Obtained information concerns different items, such as corrosion velocity and formations of oxide layers, diffusion of chemical elements from the corrosion layer to the metal and viceversa, and structural changes in oxide layers and in the metallic remains by structural ageing. Obtained data have allowed to develop a mathematical model for calculation of corrosion velocity in buried iron and steels, based on physical-chemical variables of grounds, chemical composition and thermomechanical treatment given to the metal during its manufacture. (Author)

  6. Synthesis of Paclitaxel Analogs

    OpenAIRE

    Xu, Zhibing

    2010-01-01

    Paclitaxel is one of the most successful anti-cancer drugs, particularly in the treatment of breast cancer and ovarian cancer. For the investigation of the interaction between paclitaxel and MD-2 protein, and development of new antagonists for lipopolysaccharide, several C10 A-nor-paclitaxel analogs have been synthesized and their biological activities have been evaluated. In order to reduce the myelosuppression effect of the paclitaxel, several C3â ² and C4 paclitaxel analogs have been synth...

  7. FGF growth factor analogs

    Science.gov (United States)

    Zamora, Paul O [Gaithersburg, MD; Pena, Louis A [Poquott, NY; Lin, Xinhua [Plainview, NY; Takahashi, Kazuyuki [Germantown, MD

    2012-07-24

    The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

  8. Analog circuits cookbook

    CERN Document Server

    Hickman, Ian

    2013-01-01

    Analog Circuits Cookbook presents articles about advanced circuit techniques, components and concepts, useful IC for analog signal processing in the audio range, direct digital synthesis, and ingenious video op-amp. The book also includes articles about amplitude measurements on RF signals, linear optical imager, power supplies and devices, and RF circuits and techniques. Professionals and students of electrical engineering will find the book informative and useful.

  9. Licensing Trends for Construction of New Nuclear Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Bae-Hyeuk; Ahn, Kyu-Suk; Kim, Young-Gyun; Kim, Tae-Wan; Baek, Jong-Hyuk [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    Currently in Korea, an SFR (Sodium-cooled Fast Reactor) technology proving stage reactor called PGSFR (Prototype Gen-IV SFR) is being developed by KAERI and KEPCO E and C to be constructed by 2028. After the accident of the Fukushima nuclear power plants, how to regulate and license newly developing nuclear reactors requiring higher safety goals has been issued. As a result, in leading nuclear nations developing new reactors, the close cooperation between the developer and the regulator is becoming very important. In this study, the licensing processes of leading nuclear countries were surveyed and compared with that of Korea, and a new licensing direction for PGSFR was suggested. Reviewing licensing processes for newly developing reactors of other countries, the first step of the licensing process is the pre-safety review, which is to review the reactor design. This process is not legally binding, but is a review process for a better understanding of newly applied technologies by regulators prior to starting the legally binding licensing process as the construction and operation licensing. This process provides an opportunity for the reactor developer to adopt the regulator's licensing direction and a goal to designing newly developing reactors to meet the safety requirements.

  10. A Comparative study of Analog and digital Controller On DC/DC Buck-Boost Converter Four Switch for Mobile Device Applications

    Directory of Open Access Journals (Sweden)

    Benlafkih Abdessamad

    2013-01-01

    Full Text Available this paper presents comparative performance between Analog and digital controller on DC/DC buck-boost converter four switch. The design of power electronic converter circuit with the use of closed loop scheme needs modeling and then simulating the converter using the modeled equations. This can easily be done with the help of state equations and MATLAB/SIMULINK as a tool for simulation of those state equations. DC/DC Buckboost converter in this study is operated in buck (step-down and boost (step-up modes.

  11. An adaptive, dose-finding, seamless phase 2/3 study of a long-acting glucagon-like peptide-1 analog (dulaglutide): trial design and baseline characteristics.

    Science.gov (United States)

    Geiger, Mary Jane; Skrivanek, Zachary; Gaydos, Brenda; Chien, Jenny; Berry, Scott; Berry, Donald

    2012-11-01

    Dulaglutide (dula, LY2189265) is a once-weekly glucagon-like peptide-1 analog in development for the treatment of type 2 diabetes mellitus. An adaptive, dose-finding, inferentially seamless phase 2/3 study was designed to support the development of this novel diabetes therapeutic. The study is divided into two stages based on two randomization schemes: a Bayesian adaptive scheme (stage 1) and a fixed scheme (stage 2). Stage 1 of the trial employs an adaptive, dose-finding design to lead to a dula dose-selection decision or early study termination due to futility. If dose selection occurs, the study proceeds to stage 2 to allow continued evaluation of the selected dula doses. At completion, the entire study will serve as a confirmatory phase 3 trial. The final study design is discussed, along with specifics pertaining to the actual execution of this study and selected baseline characteristics of the participants.

  12. Electrical Circuits and Water Analogies

    Science.gov (United States)

    Smith, Frederick A.; Wilson, Jerry D.

    1974-01-01

    Briefly describes water analogies for electrical circuits and presents plans for the construction of apparatus to demonstrate these analogies. Demonstrations include series circuits, parallel circuits, and capacitors. (GS)

  13. Influence of Underlap on Gate Stack DG-MOSFET for analytical study of Analog/RF performance

    Science.gov (United States)

    Kundu, Atanu; Dasgupta, Arpan; Das, Rahul; Chakraborty, Shramana; Dutta, Arka; Sarkar, Chandan K.

    2016-06-01

    In this paper, the characteristics of 18 nm Underlap Double Gate (U-DG) NMOSFET with gate stack, (GS) are presented. The high-k dielectric as gate insulator under consideration is Hafnium Dioxide (HfO2). The SiO2 padding reduces the effect of scattering at the silicon and oxide interface. The ratio of on current to off current is used for optimizing the underlap length. The Analog and RF performance comparison are shown in this paper considering the drain current (Id), the transconductance (gm), the intrinsic gain (gmRo), the intrinsic capacitances (Cgs, Cgd), the intrinsic resistances (Rgs, Rgd), the transport delay (τm), the intrinsic inductance (Hsd), the unity current gain cut-off frequency (fT) and the maximum frequency of oscillation (fmax). RF parameters are extracted using the Non Quasi Static (NQS) model of the U-DG MOSFET. The performance of single stage amplifiers using the devices is also analyzed. The sharpest transition is shown in case of U-DG-GS MOSFET with optimized underlap length and enhancement in the intrinsic capacitances and resistances, and unity Gain Bandwidth product in case of devices with GS.

  14. Managing Licensing in a Market for Technology

    DEFF Research Database (Denmark)

    Arora, Ashish; Fosfuri, Andrea; Rønde, Thomas

    2013-01-01

    the technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend on product market performance. If licensing is decentralized, the business unit forgoes valuable...... licensing opportunities because the rewards for licensing are (optimally) weaker than those for product market profits. This distortion is stronger when production-based incentives, especially private benefits, of business unit managers are more powerful, making centralization more attractive. Surprisingly...

  15. Managing Licensing in a Market for Technology

    DEFF Research Database (Denmark)

    Arora, Ashish; Rønde, Thomas; Fosfuri, Andrea

    the technology makes licensing decisions—to centralized licensing. The business unit has superior information about licensing opportunities but may not have the appropriate incentives because its rewards depend upon product market performance. If licensing is decentralized, the business unit forgoes valuable...... licensing opportunities since the rewards for licensing are (optimally) weaker than those for product market profits. This distortion is stronger when production-based incentives are more powerful, making centralization more attractive. Growth of technology markets favors centralization and drives higher...

  16. Antibacterial and Antibiofilm Activities of Makaluvamine Analogs

    Directory of Open Access Journals (Sweden)

    Bhavitavya Nijampatnam

    2014-09-01

    Full Text Available Streptococcus mutans is a key etiological agent in the formation of dental caries. The major virulence factor is its ability to form biofilms. Inhibition of S. mutans biofilms offers therapeutic prospects for the treatment and the prevention of dental caries. In this study, 14 analogs of makaluvamine, a marine alkaloid, were evaluated for their antibacterial activity against S. mutans and for their ability to inhibit S. mutans biofilm formation. All analogs contained the tricyclic pyrroloiminoquinone core of makaluvamines. The structural variations of the analogs are on the amino substituents at the 7-position of the ring and the inclusion of a tosyl group on the pyrrole ring N of the makaluvamine core. The makaluvamine analogs displayed biofilm inhibition with IC50 values ranging from 0.4 μM to 88 μM. Further, the observed bactericidal activity of the majority of the analogs was found to be consistent with the anti-biofilm activity, leading to the conclusion that the anti-biofilm activity of these analogs stems from their ability to kill S. mutans. However, three of the most potent N-tosyl analogs showed biofilm IC50 values at least an order of magnitude lower than that of bactericidal activity, indicating that the biofilm activity of these analogs is more selective and perhaps independent of bactericidal activity.

  17. Computational approaches to analogical reasoning current trends

    CERN Document Server

    Richard, Gilles

    2014-01-01

    Analogical reasoning is known as a powerful mode for drawing plausible conclusions and solving problems. It has been the topic of a huge number of works by philosophers, anthropologists, linguists, psychologists, and computer scientists. As such, it has been early studied in artificial intelligence, with a particular renewal of interest in the last decade. The present volume provides a structured view of current research trends on computational approaches to analogical reasoning. It starts with an overview of the field, with an extensive bibliography. The 14 collected contributions cover a large scope of issues. First, the use of analogical proportions and analogies is explained and discussed in various natural language processing problems, as well as in automated deduction. Then, different formal frameworks for handling analogies are presented, dealing with case-based reasoning, heuristic-driven theory projection, commonsense reasoning about incomplete rule bases, logical proportions induced by similarity an...

  18. 42 CFR 431.710 - Provisional licenses.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION State Programs for Licensing Nursing Home Administrators § 431.710 Provisional licenses. To fill a position of nursing...

  19. A study on the effects of RGB-D database scale and quality on depth analogy performance

    Science.gov (United States)

    Kim, Sunok; Kim, Youngjung; Sohn, Kwanghoon

    2016-06-01

    In the past few years, depth estimation from a single image has received increased attentions due to its wide applicability in image and video understanding. For realizing these tasks, many approaches have been developed for estimating depth from a single image based on various depth cues such as shading, motion, etc. However, they failed to estimate plausible depth map when input color image is derived from different category in training images. To alleviate these problems, data-driven approaches have been popularly developed by leveraging the discriminative power of a large scale RGB-D database. These approaches assume that there exists appearance- depth correlation in natural scenes. However, this assumption is likely to be ambiguous when local image regions have similar appearance but different geometric placement within the scene. Recently, a depth analogy (DA) has been developed by using the correlation between color image and depth gradient. DA addresses depth ambiguity problem effectively and shows reliable performance. However, no experiments are conducted to investigate the relationship between database scale and the quality of the estimated depth map. In this paper, we extensively examine the effects of database scale and quality on the performance of DA method. In order to compare the quality of DA, we collect a large scale RGB-D database using Microsoft Kinect v1 and Kinect v2 on indoor and ZED stereo camera on outdoor environments. Since the depth map obtained by Kinect v2 has high quality compared to that of Kinect v1, the depth maps from the database from Kinect v2 are more reliable. It represents that the high quality and large scale RGB-D database guarantees the high quality of the depth estimation. The experimental results show that the high quality and large scale training database leads high quality estimated depth map in both indoor and outdoor scenes.

  20. Digital and analog communication systems

    Science.gov (United States)

    Shanmugam, K. S.

    1979-01-01

    The book presents an introductory treatment of digital and analog communication systems with emphasis on digital systems. Attention is given to the following topics: systems and signal analysis, random signal theory, information and channel capacity, baseband data transmission, analog signal transmission, noise in analog communication systems, digital carrier modulation schemes, error control coding, and the digital transmission of analog signals.

  1. Analogical Reasoning in Geometry Education

    Science.gov (United States)

    Magdas, Ioana

    2015-01-01

    The analogical reasoning isn't used only in mathematics but also in everyday life. In this article we approach the analogical reasoning in Geometry Education. The novelty of this article is a classification of geometrical analogies by reasoning type and their exemplification. Our classification includes: analogies for understanding and setting a…

  2. 77 FR 65699 - Prospective Grant of Exclusive License: Development of Chemopreventive Treatments for Head and...

    Science.gov (United States)

    2012-10-30

    ... Cavity'' (HHS Ref. No. E-282-2009/0) to Rapamycin Holdings, Inc., which is located in San Antonio, TX... the expiration or termination of the exclusive evaluation option license, Rapamycin Holdings, Inc... disease. Rapamycin and its analogs are known to inhibit the activity of mTOR so in principle they...

  3. Cyclic pentapeptide analogs based on endomorphin-2 structure: cyclization studies using liquid chromatography combined with on-line mass spectrometry and tandem mass spectrometry.

    Science.gov (United States)

    Piekielna, Justyna; Kluczyk, Alicja; Perlikowska, Renata; Janecka, Anna

    2014-05-01

    The cyclization of linear analogs based on endomorphin-2 structure, Tyr/Dmt-d-Lys-Phe-Phe-Asp-NH2 and Tyr/Dmt-d-Cys-Phe-Phe-Cys-NH2 (where Dmt=2',6'-dimethyltyrosine), resulting in obtaining lactam or disulfide derivatives, was studied using liquid chromatography combined with on-line mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS). In case of cyclization via an amide bond, the formation of the cyclic monomers, cyclic but not linear dimers and even traces of cyclic trimers was observed. Disulfide bridge containing peptides was obtained by the solid-phase synthesis of the linear sequences, followed by either in-solution or on-resin cyclization. In case of the in-solution cyclization, the expected cyclic monomers were the only products. When oxidation of the cysteine residues was performed when the peptides were still on the resin, cyclic monomer and two cyclodimers, parallel and antiparallel, were found. Digestion of the isolated cyclodimers with α-chymotrypsin allowed for their unambiguous identification. The comparison of the cyclic monomer/dimer ratios for analogs with Tyr versus Dmt in position 1 revealed that the presence of the exocyclic Dmt favored formation of the cyclic monomer, most likely due to the increased steric bulk of this amino acid side-chain as compared with Tyr.

  4. Neutron-skin thickness of 208Pb, and symmetry-energy constraints from the study of the anti-analog giant dipole resonance

    CERN Document Server

    Krasznahorkay, A; Csige, L; Eriksen, T K; Giacoppo, F; Görgen, A; Hagen, T W; Harakeh, M N; Julin, R; Koehler, P; Paar, N; Siem, S; Stuhl, L; Tornyi, T; Vretenar, D

    2013-01-01

    The 208Pb(p,ngamma p)207Pb reaction at a beam energy of 30 MeV has been used to excite the anti-analog of the giant dipole resonance (AGDR) and to measure its gamma-decay of to the isobaric analog state. The energy of the transition has also been calculated with the self-consistent relativistic random-phase approximation (RRPA), and found to be linearly correlated to the predicted value of the neutron-skin thickness (DR_pn). By comparing the theoretical results with the measured transition energy, the value of 0.190 +- 0.028 fm has been determined for DR_pn of 208Pb, in agreement with previous experimental results. The AGDR excitation energy has also been used to calculate the symmetry energy at saturation (J=32.7+- 0.6 MeV) and the slope of the symmetry energy (L=49.7 +- 4.4 MeV), resulting in more stringent constraints than most of the previous studies.

  5. Ethnographic analogy, the comparative method, and archaeological special pleading.

    Science.gov (United States)

    Currie, Adrian

    2016-02-01

    Ethnographic analogy, the use of comparative data from anthropology to inform reconstructions of past human societies, has a troubled history. Archaeologists often express concern about, or outright reject, the practice--and sometimes do so in problematically general terms. This is odd, as (or so I argue) the use of comparative data in archaeology is the same pattern of reasoning as the 'comparative method' in biology, which is a well-developed and robust set of inferences which play a central role in discovering the biological past. In pointing out this continuity, I argue that there is no 'special pleading' on the part of archaeologists in this regard: biologists must overcome analogous epistemic difficulties in their use of comparative data. I then go on to emphasize the local, empirically tractable ways in which particular ethnographic analogies may be licensed.

  6. Knowledge Sharing among University Students Facilitated with a Creative Commons Licensing Mechanism: A Case Study in a Programming Course

    Science.gov (United States)

    Liu, Chen-Chung; Lin, Chia-Ching; Chang, Chun-Yi; Chao, Po-Yao

    2014-01-01

    Creative Commons (CC) mechanism has been suggested as a potential means to foster a reliable environment for online knowledge sharing activity. This study investigates the role of the CC mechanism in supporting knowledge sharing among a group of university students studying programming from the perspectives of social cognitive and social capital…

  7. Playing with a double-edged sword: Analogies in biochemistry

    Science.gov (United States)

    Orgill, Marykay

    Analogy pervades our everyday reasoning. No situation we encounter is exactly like a situation we have encountered previously, and our ability to learn and survive in the world is based on our ability to find similarities between past and present situations and use the knowledge we have gained from past situations to manage current situations. Analogies can be powerful teaching tools because they can make new material intelligible to students by comparing it to material that is already familiar. It is clear, though, that not all analogies are good and that not all good analogies are useful to all students. In this study, I have used textbook analysis, classroom observations, student interviews and instructor interviews to determine the role that analogies play in biochemistry learning. Analogies are an important teaching technique in biochemistry classes, being used more often in both biochemistry classes and textbooks than they are in high school chemistry classes and textbooks. Most biochemistry students like, pay particular attention to, and remember the analogies their instructors provide; and they use these analogies to understand, visualize, and recall information from class. Even though students like and use analogies, they do not understand what analogies are or the mechanism by which they improve learning. For the students, analogies are simply any teaching technique that eases understanding, visualization, or recall. Instructors, on the other hand, have a good understanding of what analogies are and of how they should be presented in class; but they do not use analogies as effectively as they should. They do not plan, explain or identify the limitations of the analogies they use in class. However, regardless of how effectively instructors present analogies in class, this study indicates that, in general, analogies are useful in promoting understanding, visualization, recall, and motivation in biochemistry students at all levels. They would be even more

  8. Post licensing case study of community effects at two operating nuclear power plants. Final report, March 1975--March 1976

    Energy Technology Data Exchange (ETDEWEB)

    Purdy, B.J.; Peelle, E.; Bjornstad, D.J.; Mattingly, T.J. Jr.; Soderstrom, J.; DeVault, R.C.

    1976-06-01

    The social, economic, and political/institutional impacts of two operating nuclear power complexes on two New England communities are studied. The report includes discussions of the study design and objectives, profiles of the towns of Plymouth, Massachusetts, and Waterford, Connecticut, and analysis of the social, economic, and political impacts as observed by members of the ORNL staff. Results are presented from an attitude survey as well as a social impact classification schema devised as a methodological tool.

  9. Human capital development and a Social License to Operate

    DEFF Research Database (Denmark)

    Smits, Coco; Justinussen, Jens Christian Svabo; Bertelsen, Rasmus Gjedssø

    2016-01-01

    of a Social License to Operate addresses the acceptance of an activity by local communities and other stakeholders. This manuscript explores the role human capital development in obtaining and maintaining a Social License to Operate in Iceland, the Faroe Islands and Greenland. As trust and legitimacy...... are the two fundamental principles on which a Social License to Operate is based, these are being examined more closely. On the basis of three case studies, this manuscript explores how human capital development can contribute to the legitimacy of Arctic energy development and trust building between various...

  10. Analogy, explanation, and proof.

    Science.gov (United States)

    Hummel, John E; Licato, John; Bringsjord, Selmer

    2014-01-01

    People are habitual explanation generators. At its most mundane, our propensity to explain allows us to infer that we should not drink milk that smells sour; at the other extreme, it allows us to establish facts (e.g., theorems in mathematical logic) whose truth was not even known prior to the existence of the explanation (proof). What do the cognitive operations underlying the inference that the milk is sour have in common with the proof that, say, the square root of two is irrational? Our ability to generate explanations bears striking similarities to our ability to make analogies. Both reflect a capacity to generate inferences and generalizations that go beyond the featural similarities between a novel problem and familiar problems in terms of which the novel problem may be understood. However, a notable difference between analogy-making and explanation-generation is that the former is a process in which a single source situation is used to reason about a single target, whereas the latter often requires the reasoner to integrate multiple sources of knowledge. This seemingly small difference poses a challenge to the task of marshaling our understanding of analogical reasoning to understanding explanation. We describe a model of explanation, derived from a model of analogy, adapted to permit systematic violations of this one-to-one mapping constraint. Simulation results demonstrate that the resulting model can generate explanations for novel explananda and that, like the explanations generated by human reasoners, these explanations vary in their coherence.

  11. Quantum Analog Computing

    Science.gov (United States)

    Zak, M.

    1998-01-01

    Quantum analog computing is based upon similarity between mathematical formalism of quantum mechanics and phenomena to be computed. It exploits a dynamical convergence of several competing phenomena to an attractor which can represent an externum of a function, an image, a solution to a system of ODE, or a stochastic process.

  12. Are Scientific Analogies Metaphors?

    Science.gov (United States)

    1981-02-01

    psychospiritual processes. A more modern example of unclarified analogy is Freud’s (1973; reprinted from 1955) discussion of anal- eroticism , in which...299-304. Freud, S. On transformations of instinct as exemplified in anal eroticism . In J. Strachey (Ed.), The standard 37 edition of the complete

  13. Investigating and Theorizing Discourse during Analogy Writing in Chemistry

    Science.gov (United States)

    Bellocchi, Alberto; Ritchie, Stephen M.

    2011-01-01

    Explanations of the role of analogies in learning science at a cognitive level are made in terms of creating bridges between new information and students' prior knowledge. In this empirical study of learning with analogies in an 11th grade chemistry class, we explore an alternative explanation at the "social" level where analogy shapes…

  14. Ground Penetrating Radar Field Studies of Lunar-Analog Geologic Settings and Processes: Barringer Meteor Crater and Northern Arizona Volcanics

    Science.gov (United States)

    Russell, P. S.; Grant, J. A.; Williams, K. K.; Bussey, B.

    2010-12-01

    Ground-Penetrating Radar (GPR) data from terrestrial analog environments can help constrain models for evolution of the lunar surface, aid in interpretation of orbital SAR data, and help predict what might be encountered in the subsurface during future, landed, scientific or engineering operations on the Moon. GPR can yield insight into the physical properties, clast-size distribution, and layering of the subsurface, granting a unique view of the processes affecting an area over geologic time. The purpose of our work is to demonstrate these capabilities at sites at which geologic processes, settings, and/or materials are similar to those that may be encountered on the moon, especially lava flows, impact-crater ejecta, and layered materials with varying properties. We present results from transects obtained at Barringer Meteor Crater, SP Volcano cinder cone, and Sunset Crater Volcano National Monument, all in northern Arizona. Transects were taken at several sites on the ejecta of Meteor Crater, all within a crater radius (~400 m) of the crater rim. Those taken across ejecta lobes or mounds reveal the subsurface contact of the ejecta upper surface and overlying, embaying sediments deposited by later alluvial, colluvial, and/or aeolian processes. Existing mine shafts and pits on the south side of the crater provide cross sections of the subsurface against which we compare adjacent GPR transects. The ‘actual’ number, size, and depth of clasts in the top 1-2 m of the subsurface are estimated from photos of the exposed cross sections. In GPR radargrams, reflections attributed to blocks in the top 2-5 m of the subsurface are counted, and their depth distribution noted. Taking GPR measurements along a transect at two frequencies (200 and 400 MHz) and to various depths, we obtain the ratio of the actual number of blocks in the subsurface to the number detectable with GPR, as well as an assessment of how GPR detections in ejecta decline with depth and depend on antenna

  15. Copyright licenses and legal deposit practices of grey multimedia materials

    OpenAIRE

    Debbie L. Rabina; GreyNet, Grey Literature Network Service

    2008-01-01

    The purpose of this study is to determine whether the type of copyright license under which grey multimedia materials are published makes a difference in terms of their inclusion in library catalogs. The two types of copyright licenses examined are Creative Commons and traditional copyright, and the library catalogs examined is that of the United States Library of Congress and national catalogs of countries represented in the population of the study. The population included grey multimedia ma...

  16. 25 CFR 558.5 - License suspension.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false License suspension. 558.5 Section 558.5 Indians NATIONAL... MANAGEMENT OFFICIALS § 558.5 License suspension. (a) If, after the issuance of a gaming license, the... tribe shall suspend such license and shall notify in writing the licensee of the suspension and...

  17. 31 CFR 536.305 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 536.305 Section 536.305 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Definitions § 536.305 General license. The term general license means any license or authorization the...

  18. 31 CFR 596.306 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 596.306 Section 596.306 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... Definitions § 596.306 License. Except as otherwise specified, the term license means any license...

  19. 47 CFR 27.13 - License period.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false License period. 27.13 Section 27.13... COMMUNICATIONS SERVICES Applications and Licenses § 27.13 License period. (a) 2305-2320 MHz and 2345-2360 MHz... beyond the end of the license term if no broadcast service had been provided, whichever period is...

  20. 31 CFR 586.305 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 586.305 Section 586...) KOSOVO SANCTIONS REGULATIONS General Definitions § 586.305 General license. The term general license means any license or authorization the terms of which are set forth in this part....

  1. 31 CFR 535.316 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 535.316 Section 535.316 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN....316 License. Except as otherwise specified, the term license shall mean any license or...

  2. 31 CFR 598.308 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 598.308 Section 598.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... Definitions § 598.308 License. Except as otherwise specified, the term license means any license...

  3. 31 CFR 515.317 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 515.317 Section 515.317 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 515.317 General license. A general license is any license or authorization the terms of which are...

  4. 31 CFR 575.313 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 575.313 Section 575.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... License. Except as otherwise specified, the term license means any license or authorization contained...

  5. 31 CFR 585.307 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 585.307 Section 585.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... General Definitions § 585.307 General license. The term general license means any license or...

  6. 31 CFR 560.311 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 560.311 Section 560.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 560.311 General license. The term general license means any license or authorization the terms...

  7. 27 CFR 555.42 - License fees.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false License fees. 555.42... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Licenses and Permits § 555.42 License fees. (a) Each applicant shall pay a fee for obtaining a three year license, a separate fee...

  8. 31 CFR 500.317 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 500.317 Section 500.317 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 500.317 General license. A general license is any license or authorization the terms of which are...

  9. 31 CFR 595.308 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 595.308 Section 595.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... License. Except as otherwise specified, the term license means any license or authorization contained...

  10. 31 CFR 596.305 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 596.305 Section 596.305 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... General Definitions § 596.305 General license. The term general license means any license or...

  11. 31 CFR 538.304 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 538.304 Section 538.304 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 538.304 General license. The term general license means any license or authorization the terms...

  12. 47 CFR 24.15 - License period.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false License period. 24.15 Section 24.15 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Applications and Licenses General Filing Requirements § 24.15 License period. Licenses for...

  13. 31 CFR 515.318 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 515.318 Section 515.318 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 515.318 Specific license. A specific license is any license or authorization issued pursuant to...

  14. 19 CFR 112.21 - License required.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false License required. 112.21 Section 112.21 Customs... CARRIERS, CARTMEN, AND LIGHTERMEN Licensing of Cartmen and Lightermen § 112.21 License required. A customhouse cartage or lighterage license issued by the port director in accordance with this part or...

  15. 27 CFR 478.42 - License fees.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false License fees. 478.42... EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE IN FIREARMS AND AMMUNITION Licenses § 478.42 License fees. Each applicant shall pay a fee for obtaining a firearms license or...

  16. 32 CFR 746.6 - Nonexclusive license.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Nonexclusive license. 746.6 Section 746.6... Nonexclusive license. (a) Availability of licenses. Each government invention normally shall be made available for the granting of nonexclusive revocable licenses, subject to the provisions of any other...

  17. 31 CFR 535.318 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 535.318 Section 535.318 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 535.318 Specific license. A specific license is any license or authorization issued pursuant to...

  18. 31 CFR 575.305 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 575.305 Section 575.305 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....305 General license. The term general license means any license or authorization the terms of...

  19. 31 CFR 585.308 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 585.308 Section 585.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... General Definitions § 585.308 Specific license. The term specific license means any license...

  20. 31 CFR 500.318 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 500.318 Section 500.318 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 500.318 Specific license. A specific license is any license or authorization issued pursuant to...

  1. 31 CFR 538.308 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 538.308 Section 538.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... License. Except as otherwise specified, the term license means any license or authorization contained...

  2. 31 CFR 586.315 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 586.315 Section 586...) KOSOVO SANCTIONS REGULATIONS General Definitions § 586.315 Specific license. The term specific license means any license or authorization not set forth in this part but issued pursuant to this part....

  3. 31 CFR 585.306 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 585.306 Section 585.306 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... Definitions § 585.306 License. Except as otherwise specified, the term license means any license...

  4. 10 CFR 40.3 - License requirements.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false License requirements. 40.3 Section 40.3 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF SOURCE MATERIAL General Provisions § 40.3 License requirements. A..., unless authorized in a specific or general license issued by the Commission under the regulations in...

  5. 31 CFR 536.313 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 536.313 Section 536.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... Definitions § 536.313 Specific license. The term specific license means any license or authorization not...

  6. 31 CFR 595.312 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 595.312 Section 595.312 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 595.312 Specific license. The term specific license means any license or authorization not set...

  7. 31 CFR 560.312 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 560.312 Section 560.312 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 560.312 Specific license. The term specific license means any license or authorization not set...

  8. 31 CFR 575.316 - Special license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Special license. 575.316 Section 575.316 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....316 Special license. The term specific license means any license or authorization not set forth...

  9. 31 CFR 597.313 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 597.313 Section 597.313 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... Definitions § 597.313 License. Except as otherwise specified, the term license means any license...

  10. 31 CFR 535.317 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 535.317 Section 535.317 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 535.317 General license. A general license is any license or authorization the terms of which are...

  11. 31 CFR 586.311 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 586.311 Section 586.311... SANCTIONS REGULATIONS General Definitions § 586.311 License. Except as otherwise specified, the term license means any license or authorization contained in or issued pursuant to this part....

  12. 31 CFR 560.310 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 560.310 Section 560.310 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... License. Except as otherwise specified, the term license means any license or authorization contained...

  13. 31 CFR 515.316 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 515.316 Section 515.316 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... License. Except as otherwise specified, the term license shall mean any license or authorization...

  14. 10 CFR 55.3 - License requirements.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License requirements. 55.3 Section 55.3 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES General Provisions § 55.3 License requirements. A person must be authorized by a license issued by the Commission to perform the function of an operator...

  15. 31 CFR 536.308 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 536.308 Section 536.308 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN... Definitions § 536.308 License. Except as otherwise specified, the term license means any license...

  16. 31 CFR 538.311 - Specific license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Specific license. 538.311 Section 538.311 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 538.311 Specific license. The term specific license means any license or authorization not set...

  17. 32 CFR 643.72 - License.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true License. 643.72 Section 643.72 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE Licenses § 643.72 License. A license is a bare authority to do a specified act upon the property of the...

  18. 31 CFR 500.316 - License.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false License. 500.316 Section 500.316 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN....316 License. Except as otherwise specified, the term license shall mean any license or...

  19. 31 CFR 595.305 - General license.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false General license. 595.305 Section 595.305 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... § 595.305 General license. The term general license means any license or authorization the terms...

  20. Processing Polarity Items: Contrastive Licensing Costs

    Science.gov (United States)

    Saddy, Douglas; Drenhaus, Heiner; Frisch, Stefan

    2004-01-01

    We describe an experiment that investigated the failure to license polarity items in German using event-related brain potentials (ERPs). The results reveal distinct processing reflexes associated with failure to license positive polarity items in comparison to failure to license negative polarity items. Failure to license both negative and…

  1. 42 CFR 431.705 - Licensing authority.

    Science.gov (United States)

    2010-10-01

    ...) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION State Programs for Licensing Nursing Home Administrators § 431.705 Licensing authority. (a) The State licensing program must provide for licensing of nursing home administrators by— (1) The agency designated under the healing arts...

  2. Inviting Argument by Analogy: Analogical-Mapping-Based Comparison Activities as a Scaffold for Small-Group Argumentation

    Science.gov (United States)

    Emig, Brandon R.; McDonald, Scott; Zembal-Saul, Carla; Strauss, Susan G.

    2014-01-01

    This study invited small groups to make several arguments by analogy about simple machines. Groups were first provided training on analogical (structure) mapping and were then invited to use analogical mapping as a scaffold to make arguments. In making these arguments, groups were asked to consider three simple machines: two machines that they had…

  3. Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents.

    Science.gov (United States)

    Wen, Jiachen; Bao, Yu; Niu, Qun; Liu, Jiang; Yang, Jinyu; Wang, Wanqiao; Jiang, Tao; Fan, Yinbo; Li, Kun; Wang, Jian; Zhao, Linxiang; Liu, Dan

    2016-09-01

    In this study, a concise synthetic method of psammaplin A was achieved from 3-bromo-4-hydroxybenzaldahyde and hydantoin through a four-step synthesis via Knoevenagel condensation, hydrolysis, oximation and amidation in 37% overall yield. A collection of novel psammaplin A analogs focused on the variations of substituents at the benzene ring and modifications at the oxime moiety were synthesized. Among all the synthesized compounds, 5d and 5e showed better HDAC inhibition than psammaplin A and comparable cytotoxicity against four cancer cell lines (PC-3, MCF-7, A549 and HL-60). Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.

  4. Factors associated with adherence to nucleos(t)ide analogs in chronic hepatitis B patients: results from a 1-year follow-up study.

    Science.gov (United States)

    Peng, Jie; Yin, Junhua; Cai, Shaohang; Yu, Tao; Zhong, Chunxiu

    2015-01-01

    Little is known about the factors associated with patient compliance with nucleos(t)ide analog (NUC) treatment for chronic hepatitis B (CHB). The purpose of this study was to examine the association between sociodemographic and clinical characteristics and adherence to NUCs among patients with CHB. A total of 211 CHB patients receiving NUC monotherapy were asked to report the number of prescribed doses of medication they had taken during the last 90 days. A total of four 3-month adherence scores were averaged to obtain a combined rate of NUC adherence during a 1-year follow up period. The mean age of the patients was 29.6 years, 79% were men, and 68% had no prior NUC treatment for CHB. Females, patients without a previous NUC treatment, and those who had NUC drug resistance showed better adherence to NUC treatment, and compliance was better with telbivudine than with lamivudine and entecavir.

  5. Managing technology licensing for stochastic R&D: from the perspective of an enterprise information system

    Science.gov (United States)

    Hong, Xianpei; Zhao, Dan; Wang, Zongjun

    2016-10-01

    Enterprise information technology (IT) plays an important role in technology innovation management for high-tech enterprises. However, to date most studies on enterprise technology innovation have assumed that the research and development (R&D) outcome is certain. This assumption does not always hold in practice. Motivated by the current practice of some IT industries, we establish a three-stage duopoly game model, including the R&D stage, the licensing stage and the output stage, to investigate the influence of bargaining power and technology spillover on the optimal licensing policy for the innovating enterprise when the outcome of R&D is uncertain. Our results demonstrate that (1) if the licensor has low (high) bargaining power, fixed-fee (royalty) licensing is always superior to royalty (fixed-fee) licensing to the licensor regardless of technology spillover; (2) if the licensor has moderate bargaining power and technology spillover is low (high) as well, fixed-fee (royalty) licensing is superior to royalty (fixed-fee) licensing; (3) under two-part tariff licensing and the assumption of licensors with full bargaining power, if a negative prepaid fixed fee is not allowed, two-part tariff licensing is equivalent to royalty licensing which is the optimal licensing policy; if negative prepaid fixed fee is allowed, the optimal policy is two-part tariff licensing.

  6. Comparative evaluation of pressure generated on a simulated maxillary oral analog by impression materials in custom trays of different spacer designs: An in vitro study

    Directory of Open Access Journals (Sweden)

    Sakshi Chopra

    2016-01-01

    Full Text Available Introduction: Literature reveals that masticatory load on denture bearing tissues through complete dentures should be maximum on primary stress bearing areas and least on relief area in accordance with the histology of underlying tissues. A study to validate the existing beliefs was planned to compare the pressure on mucosa using selective pressure technique and minimal pressure technique, with the incorporation of two different impression materials utilizing the pressure sensors during secondary impression procedure. Materials and Methods: The study was performed using a maxillary analog. Three pressure sensors were imbedded in the oral analog, one in the mid palatine area and the other two in the right and left ridge crest. Custom trays of two different configurations were fabricated. The two impression materials tested were light body and zinc oxide eugenol. A total of 40 impressions were made. A constant weight of 1 kg was placed, and the pressure was recorded as initial and end pressures. Results: A significant difference in the pressure produced using different impression materials was found (P < 0.001. Light body vinyl polysiloxane produced significantly lesser pressure than zinc oxide eugenol impression materials. The presence of relief did affect the magnitude of pressure at various locations. Conclusion: All impression materials produced pressure during maxillary edentulous impression making. Tray modification is an important factor in changing the amount of pressure produced. The impression materials used also had a significant role to play on the pressures acting on the tissues during impression procedure. Clinical Implication: Light body VPS impression material may be recommended to achieve minimal pressure on the denture bearing tissues in both selective as well as minimal pressure techniques.

  7. Study on Analogy Theory of Physical Simulation of In - situ Combustion%火烧油层物理模拟相似原理研究

    Institute of Scientific and Technical Information of China (English)

    刘其成; 程海清; 张勇; 赵庆辉; 刘宝良

    2013-01-01

    根据火烧油层燃烧特征,提出一种表征稠油燃烧过程参与反应的四相七组分化学动力学关系式,建立了描述火烧油层采油过程中质变、传质、传热数学模型.采用无因次处理及量纲分析方法,推导出较为完整的火烧油层物理模拟相似准则数群,示例了3种条件下的相似准则数,并对其适应性进行了分析.该研究可用于指导火烧油层物理模拟实验研究工作.%The kinetics relations of 4 - phase 7 - component that participates chemical reaction during heavy oil combustion is raised and the mathematical models of mass variation, mass transfer and heat transfer that describe in - situ combustion during production are established based on the characteristics of in - situ combustion. The relatively complete group number of analogy criteria of physical simulation of in - situ combustion is derived, analogy criterion number under 3 conditions is demonstrated and the adaptability to the criterion number is analyzed by using dimensionless process and dimension analyses. The study results can be used to guide experimental study of physical simulation of in - situ combustion.

  8. Anti-inflammatory effect of thalidomide dithiocarbamate and dithioate analogs.

    Science.gov (United States)

    Talaat, Roba; El-Sayed, Waheba; Agwa, Hussein S; Gamal-Eldeen, Amira M; Moawia, Shaden; Zahran, Magdy A H

    2015-08-05

    Thalidomide has anti-inflammatory, immunomodulatory, and anti-angiogenic properties. It has been used to treat a variety of cancers and autoimmune diseases. This study aimed to characterize anti-inflammatory activities of novel thalidomide analogs by exploring their effects on splenocytes proliferation and macrophage functions and their antioxidant activity. MTT assay was used to assess the cytotoxic effect of thalidomide analogs against splenocytes. Tumor necrosis factor (TNF-α) and nuclear factor kappa B (NF-κB-P65) were determined by enzyme-linked immunosorbent assay (ELISA). Nitric oxide (NO) was estimated by colorimetric assay. Antioxidant activity was examined by ORAC assay. Our results demonstrated that thalidomide dithioate analog 2 and thalidomide dithiocarbamate analog 4 produced a slight increase in splenocyte proliferation compared with thalidomide. Thalidomide dithiocarbamate analog 1 is a potent inhibitor of TNF-α production, whereas thalidomide dithiocarbamate analog 5 is a potent inhibitor of both TNF-α and NO. Analog 2 has a pronounced inhibitory effect on NF-κB-P65 production level. All thalidomide analogs showed prooxidant activity against hydroxyl (OH) radical. Analog 1 and thalidomide dithioate analog 3 have prooxidant activity against peroxyl (ROO) radical in relation to thalidomide. On the other hand, analog 4 has a potent scavenging capacity against peroxyl (ROO) radical compared with thalidomide. Taken together, the results of this study suggest that thalidomide analogs might have valuable anti-inflammatory activities with more pronounced effect than thalidomide itself.

  9. COMPARISON OF CERTAIN ABILITIES NEEDED BY WORKERS IN LICENSED NURSERIES AND LICENSED ORNAMENTAL HORTICULTURE BUSINESSES.

    Science.gov (United States)

    DILLON, ROY D.

    THIS STUDY WAS CONDUCTED TO DETERMINE THE EXTENT TO WHICH WORKERS WITH THE JOB TITLES OF GENERAL DIRECTORS, SALESMEN, SUPERVISORS, AND FIELD WORKERS IN LICENSED NURSERIES NEEDED AGRICULTURALLY ORIENTED KNOWLEDGE OF THE SAME KIND AND LEVEL AS WORKERS IN COMPARABLE JOB TITLES IN ORNAMENTAL HORTICULTURE BUSINESSES. DATA WERE COLLECTED BY PERSONAL…

  10. Learning Domain Theories via Analogical Transfer

    Science.gov (United States)

    2007-01-01

    Shive & Weber 1982). In the linear kinematics section of the textbook used for this study ( Giancoli 1991), there are eight worked out examples...is analogous to the dynamics of linear motion” (p. 197, Giancoli 1991). This is common practice in textbooks, and analogies between domains form the...and Worked Solution All problems and worked solutions used in this work were taken from the same physics textbook ( Giancoli 1991). Problems are

  11. VEHICLES LICENSED IN SWITZERLAND

    CERN Multimedia

    Service des Relations avec les Pays-Hôtes

    2000-01-01

    1.\tVehicle licensinga)\tTime limitsVehicles must have a Swiss registration document and Swiss number plates: -\tif the owner has been residing in Switzerland for more than one year without a break of more than three consecutive months and has been using it for more than one month on Swiss territory, or -\tif the vehicle itself has been on Swiss territory for more than one year without a break of more than three consecutive months. b)\tTechnical details Vehicles belonging to non-Swiss members of the personnel who hold a carte de légitimation issued by the Swiss Federal Department of Foreign Affairs (hereinafter referred to as 'DFAE') and who were not permanently resident in Switzerland before taking up their appointment may be licensed in Switzerland with virtually no restrictions provided that their owner produces: -\tthe vehicle registration document and number plates of the country in which the car was previously registered, or -\ta manufacturer's certi...

  12. License restrictions at Barnwell

    Energy Technology Data Exchange (ETDEWEB)

    Autry, V.R. [S.C. Dept. of Health and Environmental Control, Columbia, SC (United States). Bureau of Radiological Health

    1991-12-31

    The State of South Carolina was delegated the authority by the US Nuclear Regulatory Commission to regulate the receipt, possession, use and disposal of radioactive material as an Agreement State. Since 1970, the state has been the principal regulatory authority for the Barnwell Low-Level Waste Disposal Facility operated by Chem-Nuclear Systems, Inc. The radioactive material license issued authorizing the receipt and disposal of low-level waste contains numerous restrictions to ensure environmental protection and compliance with shallow land disposal performance criteria. Low-level waste has evolved from minimally contaminated items to complex waste streams containing high concentrations of radionuclides and processing chemicals which necessitated these restrictions. Additionally, some waste with their specific radionuclides and concentration levels, many classified as low-level radioactive waste, are not appropriate for shallow land disposal unless additional precautions are taken. This paper will represent a number of these restrictions, the rationale for them, and how they are being dealt with at the Barnwell disposal facility.

  13. Analogy, Explanation, and Proof

    Directory of Open Access Journals (Sweden)

    John eHummel

    2014-11-01

    Full Text Available People are habitual explanation generators. At its most mundane, our propensity to explain allows us to infer that we should not drink milk that smells sour; at the other extreme, it allows us to establish facts (e.g., theorems in mathematical logic whose truth was not even known prior to the existence of the explanation (proof. What do the cognitive operations underlying the (inductive inference that the milk is sour have in common with the (deductive proof that, say, the square root of two is irrational? Our ability to generate explanations bears striking similarities to our ability to make analogies. Both reflect a capacity to generate inferences and generalizations that go beyond the featural similarities between a novel problem and familiar problems in terms of which the novel problem may be understood. However, a notable difference between analogy-making and explanation-generation is that the former is a process in which a single source situation is used to reason about a single target, whereas the latter often requires the reasoner to integrate multiple sources of knowledge. This small-seeming difference poses a challenge to the task of marshaling our understanding of analogical reasoning in the service of understanding explanation. We describe a model of explanation, derived from a model of analogy, adapted to permit systematic violations of this one-to-one mapping constraint. Simulation results demonstrate that the resulting model can generate explanations for novel explananda and that, like the explanations generated by human reasoners, these explanations vary in their coherence.

  14. A Transiting Jupiter Analog

    CERN Document Server

    Kipping, David M; Henze, Chris; Teachey, Alex; Isaacson, Howard T; Petigura, Erik A; Marcy, Geoffrey W; Buchhave, Lars A; Chen, Jingjing; Bryson, Steve T; Sandford, Emily

    2016-01-01

    Decadal-long radial velocity surveys have recently started to discover analogs to the most influential planet of our solar system, Jupiter. Detecting and characterizing these worlds is expected to shape our understanding of our uniqueness in the cosmos. Despite the great successes of recent transit surveys, Jupiter analogs represent a terra incognita, owing to the strong intrinsic bias of this method against long orbital periods. We here report on the first validated transiting Jupiter analog, Kepler-167e (KOI-490.02), discovered using Kepler archival photometry orbiting the K4-dwarf KIC-3239945. With a radius of $(0.91\\pm0.02)$ $R_{\\mathrm{Jup}}$, a low orbital eccentricity ($0.06_{-0.04}^{+0.10}$) and an equilibrium temperature of $(131\\pm3)$ K, Kepler-167e bears many of the basic hallmarks of Jupiter. Kepler-167e is accompanied by three Super-Earths on compact orbits, which we also validate, leaving a large cavity of transiting worlds around the habitable-zone. With two transits and continuous photometric ...

  15. Use of analogy in learning physics: The role of representations

    Directory of Open Access Journals (Sweden)

    Noah D. Finkelstein

    2006-07-01

    Full Text Available Previous studies have demonstrated that analogies can promote student learning in physics and can be productively taught to students to support their learning, under certain conditions. We build on these studies to explore the use of analogy by students in a large introductory college physics course. In the first large-scale study of its kind, we demonstrate that different analogies can lead to varied student reasoning. When different analogies were used to teach electromagnetic (EM waves, we found that students explicitly mapped characteristics either of waves on strings or sound waves to EM waves, depending upon which analogy students were taught. We extend these results by investigating how students use analogies. Our findings suggest that representational format plays a key role in the use of analogy.

  16. Use of insulin and insulin analogs and risk of cancer - systematic review and meta-analysis of observational studies

    DEFF Research Database (Denmark)

    Karlstad, Oystein; Starup-Linde, Jacob; Vestergaard, Peter;

    2013-01-01

    -control studies examining risk of cancer associated with insulin use in patients with diabetes. DATA SOURCES: Systematic literature search in 5 databases: PubMed, Embase, Web of Science, Scopus and Cochrane Library. STUDY ELIGIBILITY CRITERIA (PICOS): POPULATION: diabetes patients. EXPOSURE: Users of any...

  17. Inductive, Analogical, and Communicative Generalization

    Directory of Open Access Journals (Sweden)

    Adri Smaling

    2003-03-01

    Full Text Available Three forms of inductive generalization - statistical generalization, variation-based generalization and theory-carried generalization - are insufficient concerning case-to-case generalization, which is a form of analogical generalization. The quality of case-to-case generalization needs to be reinforced by setting up explicit analogical argumentation. To evaluate analogical argumentation six criteria are discussed. Good analogical reasoning is an indispensable support to forms of communicative generalization - receptive and responsive (participative generalization — as well as exemplary generalization.

  18. Development of licensing process for SMART-P

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Jong Chull; Yune, Young Gill; Kim, Woong Sik (and others)

    2004-06-15

    The basic design of System-integrated Modular Advanced Reactor (SMART), a small-to-medium sized integral type pressurized water reactor (PWR) with the capacity of 330MWth, has been developed in Korea. Presently, for the purpose of demonstrating the safety and performance of the SMART design, 'Development Project of SMART-P (SMART-Pilot Plant)' is being performed as one of the 'National Mid and Long-term Atomic Energy R and D Programs', which includes design, construction, and start-up operation of the SMART-P with the capacity of 65MWth, a 1/5 scaled-down design of the SMART. At the same time, a study on the establishment of a licensing process for the SMART-P has been carried out by KINS in order to prepare for the forthcoming SMART-P licensing. The results of this study performed from Aug. of 2002 to June of 2004 can be summarized as follows: (1) The construction purpose and design characteristics of the SMRAT-P were reviewed. (2) The licensing processes for reactors in Korea, U.S.A., Japan, France, U.K., Canada, and IAEA were analyzed. (3) Reactor classification criteria were established based on the analysis results for the foreign licensing processes. And a development direction for the licensing process applicable to the development reactor was established. (4) 4 candidate models of licensing process for the development reactor were proposed based on the domestic licensing processes considering the general trends and practices of the foreign licensing processes. Evaluation of the candidate models were performed. (5) Through the expert review of the candidate models, an optimized model was finally selected and an implementation plan for the optimized model including legalization was established. The licensing process for the development reactor proposed in this study can be applied directly to the licensing of the SMART-P. Furthermore, it will be also applied to the licensing of the development reactors for the advanced reactors such as the

  19. Hegel, Analogy, and Extraterrestrial Life

    Science.gov (United States)

    Ross, Joseph T.

    Georg Wilhelm Friedrich Hegel rejected the possibility of life outside of the Earth, according to several scholars of extraterrestrial life. Their position is that the solar system and specifically the planet Earth is the unique place in the cosmos where life, intelligence, and rationality can be. The present study offers a very different interpretation of Hegel's statements about the place of life on Earth by suggesting that, although Hegel did not believe that there were other solar systems where rationality is present, he did in fact suggest that planets in general, not the Earth exclusively, have life and possibly also intelligent inhabitants. Analogical syllogisms are superficial, according to Hegel, insofar as they try to conclude that there is life on the Moon even though there is no evidence of water or air on that body. Similar analogical arguments for life on the Sun made by Johann Elert Bode and William Herschel were considered by Hegel to be equally superficial. Analogical arguments were also used by astronomers and philosophers to suggest that life could be found on other planets in our solar system. Hegel offers no critique of analogical arguments for life on other planets, and in fact Hegel believed that life would be found on other planets. Planets, after all, have meteorological processes and therefore are "living" according to his philosophical account, unlike the Moon, Sun, and comets. Whereas William Herschel was already finding great similarities between the Sun and the stars and had extended these similarities to the property of having planets or being themselves inhabitable worlds, Hegel rejected this analogy. The Sun and stars have some properties in common, but for Hegel one cannot conclude from these similarities to the necessity that stars have planets. Hegel's arguments against the presence of life in the solar system were not directed against other planets, but rather against the Sun and Moon, both of which he said have a different

  20. TOWARDS A MATHEMATICAL THEORY OF ANALOGY

    OpenAIRE

    Haraguchi, Makoto

    1985-01-01

    This paper presents a mathematical theory of analogy, which should be a basis in developing analogical reasoning by a computer. The analogy is a partial identity between two sets of facts. In order to compare several analogies, we introduce an ordering of analogies, and we define two types of optimal analogies, maximal analogies and greatest ones. We show a condition under which the greatest analogy exists, and also present a top-down procedure to find the maximal analogies.

  1. Effects of Topic Familiarity on Analogical Transfer in Problem-Solving: A Think-Aloud Study of Two Singular Cases

    Science.gov (United States)

    Gómez Ferragud, Carlos B.; Solaz-Portolés, Joan Josep; Sanjosé, Vicente

    2015-01-01

    We conducted a qualitative research of case studies based on think-aloud protocols. The aim was to carry out in-depth analyse secondary students' cognitive difficulties appearing in early stages of transfer processes in problem-solving. The task was to relate several source problems to a target problem, in order to solve it effectively. Source and…

  2. To License or Not to License Updated: An Examination of State Statutes Regarding Private Investigators and Digital Examiners

    Directory of Open Access Journals (Sweden)

    Thomas Lonardo

    2012-09-01

    Full Text Available In this update to the 2009 year's study, the authors examine statutes that regulate, license, and enforce investigative functions in each US state. After identification and review of Private Investigator licensing requirements, the authors find that very few state statutes explicitly differentiate between Private Investigators and Digital Examiners, but do see a trend of more states making some distinction. The authors contacted all state regulatory agencies where statutory language was not explicit, and as a result, set forth the various state approaches to professional Digital Examiner licensing. As was the case in the previous two iterations of this research, the authors conclude that states must differentiate between Private Investigator and Digital Examiner licensing requirements and oversight.

  3. Do Restricted Driver's Licenses Lower Crash Risk among Older Drivers? A Survival Analysis of Insurance Data from British Columbia

    Science.gov (United States)

    Nasvadi, Glenyth Caragata; Wister, Andrew

    2009-01-01

    Purpose: Faced with an aging driving population, interest is increasing in the use of restricted licenses or "graduated delicensing" for older drivers to allow them to safely retain a driver's license. The primary purpose of this study was to determine whether restricted licenses are successful at mitigating number of crashes per year…

  4. ESD analog circuits and design

    CERN Document Server

    Voldman, Steven H

    2014-01-01

    A comprehensive and in-depth review of analog circuit layout, schematic architecture, device, power network and ESD design This book will provide a balanced overview of analog circuit design layout, analog circuit schematic development, architecture of chips, and ESD design.  It will start at an introductory level and will bring the reader right up to the state-of-the-art. Two critical design aspects for analog and power integrated circuits are combined. The first design aspect covers analog circuit design techniques to achieve the desired circuit performance. The second and main aspect pres

  5. Development of analogical problem-solving skill.

    Science.gov (United States)

    Holyoak, K J; Junn, E N; Billman, D O

    1984-12-01

    3 experiments were performed to assess children's ability to solve a problem by analogy to a superficially dissimilar situation. Preschoolers and fifth and sixth graders were asked to solve a problem that allowed multiple solutions. Some subjects were first read a story that included an analogous problem and its solution. When the mapping between the relations involved in the corresponding solutions was relatively simple, and the corresponding instruments were perceptually and functionally similar, even preschoolers were able to use the analogy to derive a solution to the transfer problem (Experiment 1). Furthermore, salient similarity of the instruments was neither sufficient (Experiment 2) nor necessary (Experiment 3) for success by preschool subjects. When the story analog mapped well onto the transfer problem, 4-year-olds were often able to generate a solution that required transformation of an object with little perceptual or semantic similarity to the instrument used in the base analog (Experiment 3). The older children used analogies in a manner qualitatively similar to that observed in comparable studies with adults (Experiment 1), whereas the younger children exhibited different limitations.

  6. The Moon as a recorder of organic evolution in the early solar system: a lunar regolith analog study.

    Science.gov (United States)

    Matthewman, Richard; Court, Richard W; Crawford, Ian A; Jones, Adrian P; Joy, Katherine H; Sephton, Mark A

    2015-02-01

    The organic record of Earth older than ∼3.8 Ga has been effectively erased. Some insight is provided to us by meteorites as well as remote and direct observations of asteroids and comets left over from the formation of the Solar System. These primitive objects provide a record of early chemical evolution and a sample of material that has been delivered to Earth's surface throughout the past 4.5 billion years. Yet an effective chronicle of organic evolution on all Solar System objects, including that on planetary surfaces, is more difficult to find. Fortunately, early Earth would not have been the only recipient of organic matter-containing objects in the early Solar System. For example, a recently proposed model suggests the possibility that volatiles, including organic material, remain archived in buried paleoregolith deposits intercalated with lava flows on the Moon. Where asteroids and comets allow the study of processes before planet formation, the lunar record could extend that chronicle to early biological evolution on the planets. In this study, we use selected free and polymeric organic materials to assess the hypothesis that organic matter can survive the effects of heating in the lunar regolith by overlying lava flows. Results indicate that the presence of lunar regolith simulant appears to promote polymerization and, therefore, preservation of organic matter. Once polymerized, the mineral-hosted newly formed organic network is relatively protected from further thermal degradation. Our findings reveal the thermal conditions under which preservation of organic matter on the Moon is viable.

  7. A Vehicle License Plate Detection and Recognition System

    Directory of Open Access Journals (Sweden)

    Khalid W. Maglad

    2012-01-01

    Full Text Available Problem statement: Automatic vehicle license plate detection and recognition is a key technique in most of traffic related applications and is an active research topic in the image processing domain. Different methods, techniques and algorithms have been developed for license plate detection and recognitions. Approach: Due to the varying characteristics of the license plate from country to country like numbering system, colors, language of characters, style (font and sizes of license plate, further research is still needed in this area. Results: In most of the Middle East countries, they use the combination of Arabic and English letters, along with their countries logo. Thus, it makes the localization of plate number, the differentiation between Arabic and English letters and logo’s object and finally the recognition of those characters become a more challenging research task. The use of artificial neural network has proved itself beneficial for plate recognition, but it has not been applied for the plate detection. Radial Basis Function (RBF neural network is used both for the detection and recognition of Saudi Arabian license plates. Conclusion/Recommendations: The proposed approach has been tested on 200 front images of national license plate of Saudi Arabia. A higher percentage of accuracy has been obtained to show that the significant of this approach. The study could be further investigated in other Middle East countries.

  8. Molecular docking, kinetics study, and structure-activity relationship analysis of quercetin and its analogous as Helicobacter pylori urease inhibitors.

    Science.gov (United States)

    Xiao, Zhu-Ping; Wang, Xu-Dong; Peng, Zhi-Yun; Huang, Shen; Yang, Pan; Li, Qing-Shan; Zhou, Li-Hu; Hu, Xiao-Jun; Wu, Li-Jun; Zhou, Yin; Zhu, Hai-Liang

    2012-10-24

    It was disclosed in our group for the first time that the flavonoids in Lonicera japonica Thunb. are related to its therapy for gastric ulcer. Based on this finding, 20 flavonoids were selected for Helicobacter pylori urease inhibitory activity evaluation, and quercetin showed excellent potency with IC(50) of 11.2 ± 0.9 μM. Structure-activity relationship analysis revealed that removal of the 5-, 3-, or 3'-OH in quercetin led to a sharp decrease in activity. Thus, 3- and 5-OH as well as 3',4'-dihydroxyl groups are believed to be the key structural characteristics for active compounds, which was supported by the molecular docking study. Meanwhile, the results obtained from molecular docking and enzymatic kinetics research strongly suggested that quercetin is a noncompetitive urease inhibitor, indicating that quercetin may be able to tolerate extensive structural modification irrespective of the shape of the active site cavity and could be used as a lead candidate for the development of novel urease inhibitors.

  9. Mountain building, from subduction to collision and erosion: insights from 30 years of field and analog modeling studies (Stephan Mueller Medal Lecture)

    Science.gov (United States)

    Malavieille, J.

    2012-04-01

    Through a rapid overview of my research career, I will outline the role of the primary mechanisms and processes, which exert a strong control on mountain building. Field observations (both from structural geology on-land and marine geophysical surveys at sea), and analog modeling are the two main approaches that I used and developed during more than 30 years of research studying mountain belts at Montpellier University. The substantial contributions made through collaborations and exchanges with colleagues and students will be acknowledged. As mountain belts are long lived structures, their evolution involves numerous processes that interact since the early history, beginning during oceanic subduction and ending during the late orogenic evolution which leads to erosion and the ultimate destruction of topography. Most orogens form in subduction settings due to plate convergence involving large horizontal shortening and strong deformation of the crust developing into an overall wedge shape during their evolution. I will focus on orogens caused by subduction of a continental margin lower-plate under an oceanic or continental upper-plate following oceanic subduction, a process also commonly known as collision. After development of a sedimentary accretionary prism and closure of the oceanic domain, continuous subduction of the lithospheric mantle induces deformation of the continental crust and controls the structural asymmetry of the mountain belt. Since the pioneer works by Dahlen, Davis and Suppe in the Eighties, mountain belts have been often considered by geologists as crustal scale accretionary wedges whose deformation mechanisms can be satisfactorily described by a Coulomb behavior. The theory offers a simple mechanical framework allowing a division into different tectonic regimes depending on wedge stability : critical, undercritical, overcritical. Since then, it has been shown that orogens commonly adopt a distinct geometry with a low-tapered pro-wedge facing

  10. Pharmacophore modeling and conformational analysis in the gas phase and in aqueous solution of regioisomeric melatonin analogs. A theoretical and experimental study

    Science.gov (United States)

    Mendoza-Figueroa, Humberto; Martínez-Gudiño, Gelacio; Villanueva-Luna, Jorge E.; Trujillo-Serrato, Joel J.; Morales-Ríos, Martha S.

    2017-04-01

    In this work, 2-(N-acylaminoalkyl)indoles 1a-1d, that incorporate a pMeOBn group at the 3-position of the indole ring were virtual screened as potential melatoninergic ligands by analog-based design study using pharmacophore modeling. Pharmacophore models for melatoninergic agonist and antagonist activity were developed in order to identify the molecular constraints that define the geometric relationship among chemical features in each model. The best hypothesis consisted of six features for agonists and eight features for antagonists. The models suggest that the agonists and antagonists can share the same 3D arrangement for the six common pharmacophoric elements identified: two hydrogen bond acceptors (HBA), one hydrogen bond donor (HBD), one hydrophobic area (H), and two aromatic rings (AR). The extra hydrofobic interaction might be used as criterion for identified the pharmacological antagonist profile. Based on the pharmacophore fit, it was found that structures 1c and 1d show a good structural overlay that meets the requirements for the antagonistic pharmacophore hypothesis. Molecular modeling studies using the PCM solvation model predicted that the most stable conformers of 1a-1d match the antagonist pharmacophore hypothesis in contrast to those in the gas phase. Structures 1a-1c were synthesized only but the activities were not tested.

  11. Excited state intramolecular proton transfer (ESIPT) in 2-(2'-hydroxyphenyl)benzoxazole and its naphthalene-fused analogs: a TD-DFT quantum chemical study.

    Science.gov (United States)

    Roohi, Hossein; Hejazi, Fahimeh; Mohtamedifar, Nafiseh; Jahantab, Mahjobeh

    2014-01-24

    The intramolecular proton transfer reactions in 2-(2'-hydroxyphenyl)benzoxazole (HBO) and its naphthalene-fused analogs, (HNB1-3) in both S0 and S1 states at the PBE1PBE/6-311++G(2d,2p) level of theory in the gas phase and water have been investigated to find the effects of extension of aromaticity on the intramolecular proton transfer and photophysical properties. The results show that the ground state intramolecular proton transfer (GSIPT) in the studied species is impossible. Excited states potential energy surface calculations support the existence of ESIPT process. Structural parameters, relative energy of isomers, H-bonding energy, adsorption and emission bands, vertical excitation and emission energies, oscillator strength, fluorescence rate constant, dipole moment, atomic charges and electron density at critical points were calculated. Orbital analysis shows that vertical S0→S1 transition in the studied molecules corresponds essentially to the excitation from HOMO (π) to LUMO (π(*)). The potential of HNB2 molecule as an emissive and electron transport material in designing improved organic white light emitting diodes is predicted in this work. Our calculations are also supported by the experimental observations.

  12. Effect of a combined continuous and intermittent transcutaneous electrical nerve stimulation on pain perception of burn patients evaluated by visual analog scale: a pilot study

    Science.gov (United States)

    Pérez-Ruvalcaba, Irma; Sánchez-Hernández, Viridiana; Mercado-Sesma, Arieh R

    2015-01-01

    Aim The aim of this study was to assess the effect of continuous and intermittent electrical transcutaneous nerve stimulation on the perception of pain in patients with burns of different types. Materials and methods A pilot study was conducted in 14 patients (age 30.9±7.5 years) with second- and third-degree burns of different types. The burn types included electrical, fire/flame, and chemical. All patients received continuous and intermittent electrical transcutaneous nerve stimulation sessions three times per week for 4 weeks. Each session had a duration of 30 minutes. A pair of electrodes were placed around the burn. The primary efficacy endpoint was the perception of pain assessed by a visual analog scale at baseline and at the 30th day. Results A significant reduction of pain perception was reported (8.0±1.7 vs 1.0±0.5; P=0.027) by all patients after electrical stimulation therapy. There were no reports of adverse events during the intervention period. Conclusion Electrical stimulation could be a potential nonpharmacological therapeutic option for pain management in burn patients. PMID:26719723

  13. Albert Einstein, Analogizer Extraordinaire

    CERN Document Server

    CERN. Geneva

    2007-01-01

    Where does deep insight in physics come from? It is tempting to think that it comes from the purest and most precise of reasoning, following ironclad laws of thought that compel the clear mind completely rigidly. And yet the truth is quite otherwise. One finds, when one looks closely at any major discovery, that the greatest of physicists are, in some sense, the most crazily daring and irrational of all physicists. Albert Einstein exemplifies this thesis in spades. In this talk I will describe the key role, throughout Albert Einstein's fabulously creative life, played by wild guesses made by analogy lacking any basis whatsoever in pure reasoning. In particular, in this year of 2007, the centenary of 1907, I will describe how over the course of two years (1905 through 1907) of pondering, Einstein slowly came, via analogy, to understand the full, radical consequences of the equation that he had first discovered and published in 1905, arguably the most famous equation of all time: E = mc2.

  14. NRC licensing requirements: DOD options

    Energy Technology Data Exchange (ETDEWEB)

    Pike, W.J.; O' Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with /sup 90/Sr or /sup 238/Pu; radioisotopic dynamic electric generators with /sup 90/Sr or /sup 238/Pu; and applications of radioisotopes for luminous sources (lights) with /sup 3/H, /sup 85/Kr, or /sup 147/Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process.

  15. 76 FR 62408 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2011-10-07

    ... COMMISSION Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary licenses have been reissued by the Federal Maritime Commission... Commission pertaining to the licensing of Ocean Transportation Intermediaries, 46 CFR part 515. License...

  16. Driving Cessation Anno 2010 Which Older Drivers Give Up Their License and Why? Evidence From Denmark

    DEFF Research Database (Denmark)

    Siren, Anu Kristiina; Haustein, Sonja

    2016-01-01

    This study focuses on the decision to either stop or continue driving among a cohort of Danish seniors whose driving licenses expire, for the first time, at the age of 70. Based on 1,537 standardized telephone interviews with licensed drivers, we compared persons who intended to renew...... or not to renew their licenses. The results partly recapture the findings of earlier studies. However, in contrast to former cohorts, a much higher percentage of older drivers intended to keep their licenses. The strongest factors predicting the intention to renew were active car use, feeling safe as a driver...

  17. The Neuromechanism Underlying Language Analogical Reasoning:Evidence from An ERP Study%语言类比推理的神经机制:来自ERP研究的证据

    Institute of Scientific and Technical Information of China (English)

    赵鸣; 徐知媛; 刘涛; 杜锋磊; 李永欣; 陈飞燕

    2012-01-01

    实验通过“A∶B∶∶C∶D”范式,采用事件相关电位技术,考察了语言类比推理的神经机制.实验结果显示:图式生成阶段诱发出N400和P300成分,反映了类比源域的词对概念通达和词对关系抽取的加工过程;类比映射阶段诱发出N400和晚期负成分LNC,反映了类比目标域前项词汇概念意义的激活,以及将已获取的图式关系类比映射于目标域,并进行推理的加工过程.研究结果表明,语言类比推理的神经机制复杂,牵涉到一系列认知加工步骤;LNC成分与类比映射阶段的加工关系密切,其波幅和头皮分布的广泛性情况与类比映射关系的复杂程度成正比.%Analogical reasoning as the mechanism of acquisition of new information by inspection of specific instances, is clearly at the heart of advanced human cognitive capabilities and creativity. Especially, language analogical reasoning, as an important part of everyday discourse, is the most common one. Only a few brain imaging studies have used verbal analogies to explore the neural substrates of analogical thinking. Nevertheless, hemodynamic techniques have excellent spatial resolution but poor temporal resolution; hence, these results could not clearly reflect different substeps of analogical processes. Compared with hemodynamic techniques, event-related potentials (ERPs), as an electromagnetic technique, are sensitive to the time course of cognitive processes. However, there has no ERP study on this matter so far. Using the "A:B::C:D" paradigm, this study investigated the neuromechanism underlying language analogical reasoning by ERPs. Six hundred two-character Chinese noun words were chosen from the Contemporary Chinese Dictionary (the fifth edition) to serve as experimental stimuli. One hundred fifty trials consisting of four noun words were used in three analogy tasks with three semantic relations: metaphor, category and isomorphism, each analogy task had SO trials. Fourteen

  18. In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations.

    Science.gov (United States)

    Gao, Xiaodong; Han, Liping; Ren, Yujie

    2016-05-05

    Checkpoint kinase 1 (Chk1) is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling, molecular docking, and molecular dynamics simulations. The optimal QSAR models showed significant cross-validated correlation q² values (0.531, 0.726), fitted correlation r² coefficients (higher than 0.90), and standard error of prediction (less than 0.250). These results suggested that the developed models possess good predictive ability. Moreover, molecular docking and molecular dynamics simulations were applied to highlight the important interactions between the ligand and the Chk1 receptor protein. This study shows that hydrogen bonding and electrostatic forces are key interactions that confer bioactivity.

  19. Synthesis and Antifungal Activity against Fusarium oxysporum of Some Brassinin Analogs Derived from l-tryptophan: A DFT/B3LYP Study on the Reaction Mechanism

    Directory of Open Access Journals (Sweden)

    Diego Quiroga

    2016-10-01

    Full Text Available An efficient methodology to obtain novel antifungal analogs of brassinin 1 is described. Starting from l-tryptophan 2, N,N′-dialkylthiourea 4, 4-[(1H-indol-3-ylmethylene]-2-sulfanylidene-1,3-thiazolidin-5-one 5 and alkyl (2S-3-(1H-indol-3-yl-2-{[(alkylsulfanylcarbonothioyl]amino}propanoate 6 type compounds were obtained as main products in different ratios depending on the reaction conditions via a tandem dithiocarbamate formation and Michael addition reaction. In order to understand the dependence of the reaction conditions on the mechanism pathway, a DFT/B3LYP study was performed. The results suggested the existence of competitive mechanistic routes which involve the presence of an ionic dithiocarbamate intermediate 9. Antifungal activities of all products were then evaluated against Fusarium oxysporum through mycelial growth inhibition using a microscale amended-medium assay. IC50 values were thus determined for each compound. These results showed that 6-related compounds can be considered as promissory antifungal agents.

  20. In Silico Exploration of 1,7-Diazacarbazole Analogs as Checkpoint Kinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study, and Molecular Dynamics Simulations

    Directory of Open Access Journals (Sweden)

    Xiaodong Gao

    2016-05-01

    Full Text Available Checkpoint kinase 1 (Chk1 is an important serine/threonine kinase with a self-protection function. The combination of Chk1 inhibitors and anti-cancer drugs can enhance the selectivity of tumor therapy. In this work, a set of 1,7-diazacarbazole analogs were identified as potent Chk1 inhibitors through a series of computer-aided drug design processes, including three-dimensional quantitative structure–activity relationship (3D-QSAR modeling, molecular docking, and molecular dynamics simulations. The optimal QSAR models showed significant cross-validated correlation q2 values (0.531, 0.726, fitted correlation r2 coefficients (higher than 0.90, and standard error of prediction (less than 0.250. These results suggested that the developed models possess good predictive ability. Moreover, molecular docking and molecular dynamics simulations were applied to highlight the important interactions between the ligand and the Chk1 receptor protein. This study shows that hydrogen bonding and electrostatic forces are key interactions that confer bioactivity.

  1. Factors associated with adherence to nucleos(tide analogs in chronic hepatitis B patients: results from a 1-year follow-up study

    Directory of Open Access Journals (Sweden)

    Peng J

    2015-01-01

    Full Text Available Jie Peng, Junhua Yin, Shaohang Cai, Tao Yu, Chunxiu Zhong Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China Abstract: Little is known about the factors associated with patient compliance with nucleos(tide analog (NUC treatment for chronic hepatitis B (CHB. The purpose of this study was to examine the association between sociodemographic and clinical characteristics and adherence to NUCs among patients with CHB. A total of 211 CHB patients receiving NUC monotherapy were asked to report the number of prescribed doses of medication they had taken during the last 90 days. A total of four 3-month adherence scores were averaged to obtain a combined rate of NUC adherence during a 1-year follow up period. The mean age of the patients was 29.6 years, 79% were men, and 68% had no prior NUC treatment for CHB. Females, patients without a previous NUC treatment, and those who had NUC drug resistance showed better adherence to NUC treatment, and compliance was better with telbivudine than with lamivudine and entecavir. Keywords: chronic hepatitis B, nucleos(tide analogues, adherence, follow-up, resistance

  2. Study of the photon-induced formation and subsequent desorption of CH3 OH and H2 CO in interstellar ice analogs

    CERN Document Server

    Martín-Doménech, R; Cruz-Díaz, G A

    2016-01-01

    Methanol and formaldehyde are two simple organic molecules that are ubiquitously detected in the interstellar medium. An origin in the solid phase and a subsequent nonthermal desorption into the gas phase is often invoked to explain their abundances in some of the environments where they are found. Experimental simulations under astrophysically relevant conditions have been carried out to find a suitable mechanism for that process. We explore the in situ formation and subsequent photon-induced desorption of these species, studying the UV photoprocessing of pure ethanol ice, and a more realistic binary H2O:CH4 ice analog. Ice samples deposited onto an infrared transparent window at 8 K were UV-irradiated using a microwave-discharged hydrogen flow lamp. Evidence of photochemical production of these two species and subsequent UV-photon-induced desorption into the gas phase were searched for by means of a Fourier transform infrared spectrometer and a quadrupole mass spectrometer, respectively. Formation of CH3OH ...

  3. List of Nuclear Materials Licensing Actions Received

    Data.gov (United States)

    Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

  4. Scallop License Limitation Program (SLLP) Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A federal Scallop License Limitation Program (SLLP) license is required onboard any vessel deployed in scallop fisheries in Federal waters off Alaska (except for...

  5. Importance of tunneling in H-abstraction reactions by OH radicals. The case of CH4 + OH studied through isotope-substituted analogs

    Science.gov (United States)

    Lamberts, T.; Fedoseev, G.; Kästner, J.; Ioppolo, S.; Linnartz, H.

    2017-03-01

    We present a combined experimental and theoretical study focussing on the quantum tunneling of atoms in the reaction between CH4 and OH. The importance of this reaction pathway is derived by investigating isotope substituted analogs. Quantitative reaction rates needed for astrochemical models at low temperature are currently unavailable both in the solid state and in the gas phase. Here, we study tunneling effects upon hydrogen abstraction in CH4 + OH by focusing on two reactions: CH4 + OD → CH3 + HDO and CD4 + OH → CD3 + HDO. The experimental study shows that the solid-state reaction rate RCH4 + OD is higher than RCD4 + OH at 15 K. Experimental results are accompanied by calculations of the corresponding unimolecular and bimolecular reaction rate constants using instanton theory taking into account surface effects. For the work presented here, the unimolecular reactions are particularly interesting as these provide insight into reactions following a Langmuir-Hinshelwood process. The resulting ratio of the rate constants shows that the H abstraction (kCH4 + OD) is approximately ten times faster than D-abstraction (kCD4 + OH) at 65 K. We conclude that tunneling is involved at low temperatures in the abstraction reactions studied here. The unimolecular rate constants can be used by the modeling community as a first approach to describe OH-mediated abstraction reactions in the solid phase. For this reason we provide fits of our calculated rate constants that allow the inclusion of these reactions in models in a straightforward fashion.

  6. Vorticity in analog gravity

    Science.gov (United States)

    Cropp, Bethan; Liberati, Stefano; Turcati, Rodrigo

    2016-06-01

    In the analog gravity framework, the acoustic disturbances in a moving fluid can be described by an equation of motion identical to a relativistic scalar massless field propagating in curved space-time. This description is possible only when the fluid under consideration is barotropic, inviscid, and irrotational. In this case, the propagation of the perturbations is governed by an acoustic metric that depends algebrically on the local speed of sound, density, and the background flow velocity, the latter assumed to be vorticity-free. In this work we provide a straightforward extension in order to go beyond the irrotational constraint. Using a charged—relativistic and nonrelativistic—Bose-Einstein condensate as a physical system, we show that in the low-momentum limit and performing the eikonal approximation we can derive a d’Alembertian equation of motion for the charged phonons where the emergent acoustic metric depends on flow velocity in the presence of vorticity.

  7. Feedback in analog circuits

    CERN Document Server

    Ochoa, Agustin

    2016-01-01

    This book describes a consistent and direct methodology to the analysis and design of analog circuits with particular application to circuits containing feedback. The analysis and design of circuits containing feedback is generally presented by either following a series of examples where each circuit is simplified through the use of insight or experience (someone else’s), or a complete nodal-matrix analysis generating lots of algebra. Neither of these approaches leads to gaining insight into the design process easily. The author develops a systematic approach to circuit analysis, the Driving Point Impedance and Signal Flow Graphs (DPI/SFG) method that does not require a-priori insight to the circuit being considered and results in factored analysis supporting the design function. This approach enables designers to account fully for loading and the bi-directional nature of elements both in the feedback path and in the amplifier itself, properties many times assumed negligible and ignored. Feedback circuits a...

  8. Effects of Multimedia and Schema Induced Analogical Reasoning on Science Learning

    Science.gov (United States)

    Zheng, R. Z.; Yang, W.; Garcia, D.; McCadden, E. P.

    2008-01-01

    The present study investigates the effects of multimedia and schema induced analogical reasoning on science learning. It involves 89 fourth grade elementary students in the north-east of the United States. Participants are randomly assigned into four conditions: (a) multimedia with analogy; (b) multimedia without analogy; (c) analogy without…

  9. 3~11岁儿童类比推理发展的研究%3~11Years Old Children’s Analogical Reasoning:A Developmental Study

    Institute of Scientific and Technical Information of China (English)

    费广洪; 王淑娟

    2014-01-01

    该研究随机抽取180名3~11岁儿童,采用几何图形、关系图形、词语、数字、故事五种材料,考察儿童类比推理发展的年龄特点和规律。结果发现:(1)4~5岁儿童开始能够进行类比推理,类比推理随年龄的增长逐渐发展,呈上升趋势;(2)儿童类比推理的发展表现出阶段性的特点;(3)儿童类比推理的发展不受材料影响,具有一定稳定性;(4)小学高年级儿童类比推理发展水平较高,学前儿童水平较低。%This study randomly selected 180 children aged 3~11,used five kinds of materials including geometry,relations graphics, word,number and story to investigate the age characteristic of the children’s analogical reasoning development. The results showed that:(1)4~5 years old children began to be able to analogize and the ability of analogical reasoning gradually developed along with the growth of the age.(2)The development of children’s analogical reasoning showed the characteristic of stage 4~11 years old children’ s analogical reasoning development can be divided into four stages.(3)The development of children’s analogical reasoning is not affect-ed by materials,has certain stability.(4)The developmental level of elementary school higher grade children’s in analogical reasoning is higher but the developmental level of pre-school children’s in analogical reasoning is lower.

  10. 25 CFR 11.601 - Marriage licenses.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Marriage licenses. 11.601 Section 11.601 Indians BUREAU... ORDER CODE Domestic Relations § 11.601 Marriage licenses. A marriage license shall be issued by the clerk of the court in the absence of any showing that the proposed marriage would be invalid under...

  11. 14 CFR 1274.942 - Export licenses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Export licenses. 1274.942 Section 1274.942... FIRMS Other Provisions and Special Conditions § 1274.942 Export licenses. Export Licenses July 2002 (a) The Recipient shall comply with all U.S. export control laws and regulations, including...

  12. 7 CFR 1530.103 - License eligibility.

    Science.gov (United States)

    2010-01-01

    ... license held by an affiliated person. (c) Notwithstanding paragraph (b) of this section, a person who owns one or more wholly-owned subsidiary corporations manufacturing sugar containing products or producing... license. The sum total of license limits for the parent corporation and its wholly-owned...

  13. 47 CFR 13.15 - License term.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false License term. 13.15 Section 13.15 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.15 License term... years from the date of issuance. (b) General Radiotelephone Operator Licenses, Restricted...

  14. 10 CFR 61.3 - License required.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License required. 61.3 Section 61.3 Energy NUCLEAR... Provisions § 61.3 License required. (a) No person may receive, possess, and dispose of radioactive waste... license issued by the Commission pursuant to this part, or unless exemption has been granted by...

  15. 10 CFR 60.3 - License required.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License required. 60.3 Section 60.3 Energy NUCLEAR... Provisions § 60.3 License required. (a) DOE shall not receive or possess source, special nuclear, or byproduct material at a geologic repository operations area except as authorized by a license issued by...

  16. 10 CFR 70.3 - License requirements.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License requirements. 70.3 Section 70.3 Energy NUCLEAR... License requirements. No person subject to the regulations in this part shall receive title to, own... license issued by the Commission pursuant to these regulations....

  17. 10 CFR 35.11 - License required.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false License required. 35.11 Section 35.11 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.11 License required. (a) A... for medical use only in accordance with a specific license issued by the Commission or an...

  18. 10 CFR 35.18 - License issuance.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false License issuance. 35.18 Section 35.18 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.18 License issuance. (a) The Commission shall issue a license for the medical use of byproduct material if— (1) The applicant has...

  19. 47 CFR 27.1212 - License term.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false License term. 27.1212 Section 27.1212... COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1212 License term. (a) BRS/EBS licenses shall be issued for a period of 10 years beginning with the date of grant. (b) An...

  20. 10 CFR 63.3 - License required.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false License required. 63.3 Section 63.3 Energy NUCLEAR... MOUNTAIN, NEVADA General Provisions § 63.3 License required. (a) DOE may not receive nor possess source... except as authorized by a license issued by the Commission under this part. (b) DOE may not...

  1. 22 CFR 120.20 - License.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false License. 120.20 Section 120.20 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.20 License. License means a document bearing the word “license” issued by the Directorate of Defense...

  2. 27 CFR 478.44 - Original license.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Original license. 478.44... EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE IN FIREARMS AND AMMUNITION Licenses § 478.44 Original license. (a)(1) Any person who intends to engage in business as a firearms or...

  3. Beginning analog electronics through projects

    CERN Document Server

    Singmin, Andrew

    2001-01-01

    Analog electronics is the simplest way to start a fun, informative, learning program. Beginning Analog Electronics Through Projects, Second Edition was written with the needs of beginning hobbyists and students in mind. This revision of Andrew Singmin's popular Beginning Electronics Through Projects provides practical exercises, building techniques, and ideas for useful electronics projects. Additionally, it features new material on analog and digital electronics, and new projects for troubleshooting test equipment.Published in the tradition of Beginning Electronics Through Projects an

  4. License plate recognition using DTCNNs

    NARCIS (Netherlands)

    ter Brugge, M.H; Stevens, J.H; Nijhuis, J.A G; Spaanenburg, L; Tavsanonoglu, V

    1998-01-01

    Automatic license plate recognition requires a series of complex image processing steps. For practical use, the amount of data to he processed must be minimized early on. This paper shows that the computationally most intensive steps can be realized by DTCNNs. Moreover; high-level operations like fi

  5. Wavelet packet based feature extraction and recognition of license plate characters

    Institute of Scientific and Technical Information of China (English)

    HUANG Wei; LU Xiaobo; LING Xiaojing

    2005-01-01

    To study the characteristics of license plate characters recognition, this paper proposes a method for feature extraction of license plate characters based on two-dimensional wavelet packet. We decompose license plate character images with two dimensional-wavelet packet and search for the optimal wavelet packet basis. This paper presents a criterion of searching for the optimal wavelet packet basis, and a practical algorithm. The obtained optimal wavelet packet basis is used as the feature of license plate character, and a BP neural network is used to classify the character.The testing results show that the proposed method achieved higher recognition rate than the traditional methods.

  6. Analog Module Placement Design Using Genetic Algorithm

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    This paper presents a novel genetic algorithm for analog module placement based on ageneralization of the two-dimensional bin packing problem. The genetic encoding and operators assure that allproblem constraints are always satisfied. Thus the potential problems of adding penalty terms to the costfunction are eliminated so that the search configuration space is drastically decreased. The dedicated costfunction is based on the special requirements of analog integrated circuits. A fractional factorial experimentwas conducted using an orthogonal array to study the algorithm parameters. A meta GA was applied todetermine the optimal parameter values. The algorithm was tested with several local benchmark circuits. Theexperimental results show that the algorithm has better performance than the simulated annealing approachwith satisfactory results comparable to manual placement. This study demonstrates the effectiveness of thegenetic algorithm in the analog module placement problem. The algorithm has been successfully used in alayout synthesis tool.

  7. Electronic devices for analog signal processing

    CERN Document Server

    Rybin, Yu K

    2012-01-01

    Electronic Devices for Analog Signal Processing is intended for engineers and post graduates and considers electronic devices applied to process analog signals in instrument making, automation, measurements, and other branches of technology. They perform various transformations of electrical signals: scaling, integration, logarithming, etc. The need in their deeper study is caused, on the one hand, by the extension of the forms of the input signal and increasing accuracy and performance of such devices, and on the other hand, new devices constantly emerge and are already widely used in practice, but no information about them are written in books on electronics. The basic approach of presenting the material in Electronic Devices for Analog Signal Processing can be formulated as follows: the study with help from self-education. While divided into seven chapters, each chapter contains theoretical material, examples of practical problems, questions and tests. The most difficult questions are marked by a diamon...

  8. Effect of a combined continuous and intermittent transcutaneous electrical nerve stimulation on pain perception of burn patients evaluated by visual analog scale: a pilot study

    Directory of Open Access Journals (Sweden)

    Pérez-Ruvalcaba I

    2015-12-01

    Full Text Available Irma Pérez-Ruvalcaba,1 Viridiana Sánchez-Hernández,1 Arieh R Mercado-Sesma2,3 1Burn Unit, Hospital de Especialidades, Centro Médico Nacional de Occidente, Mexican Institute of Social Security, 2Health Sciences Department, Centro Universitario de Tonalá, University of Guadalajara, Guadalajara, Mexico; 3Diabetes sin Complicaciones, Zapopan, Mexico Aim: The aim of this study was to assess the effect of continuous and intermittent electrical transcutaneous nerve stimulation on the perception of pain in patients with burns of different types. Materials and methods: A pilot study was conducted in 14 patients (age 30.9±7.5 years with second- and third-degree burns of different types. The burn types included electrical, fire/flame, and chemical. All patients received continuous and intermittent electrical transcutaneous nerve stimulation sessions three times per week for 4 weeks. Each session had a duration of 30 minutes. A pair of electrodes were placed around the burn. The primary efficacy endpoint was the perception of pain assessed by a visual analog scale at baseline and at the 30th day. Results: A significant reduction of pain perception was reported (8.0±1.7 vs 1.0±0.5; P=0.027 by all patients after electrical stimulation therapy. There were no reports of adverse events during the intervention period. Conclusion: Electrical stimulation could be a potential nonpharmacological therapeutic option for pain management in burn patients. Keywords: TENS, burn pain, pain management, electrotherapy

  9. [Analogies and analogy research in technical biology and bionics].

    Science.gov (United States)

    Nachtigall, Werner

    2010-01-01

    The procedural approaches of Technical Biology and Bionics are characterized, and analogy research is identified as their common basis. The actual creative aspect in bionical research lies in recognizing and exploiting technically oriented analogies underlying a specific biological prototype to indicate a specific technical application.

  10. Magnetic activity of seismic solar analogs

    CERN Document Server

    Salabert, D

    2016-01-01

    We present our latest results on the solar-stellar connection by studying 18 solar analogs that we identified among the Kepler seismic sample (Salabert et al., 2016a). We measured their magnetic activity properties using observations collected by the Kepler satellite and the ground-based, high-resolution Hermes spectrograph. The photospheric (Sph) and chromospheric (S) magnetic activity proxies of these seismic solar analogs are compared in relation to solar activity. We show that the activity of the Sun is actually comparable to the activity of the seismic solar analogs. Furthermore, we report on the discovery of temporal variability in the acoustic frequencies of the young (1 Gyr-old) solar analog KIC10644253 with a modulation of about 1.5 years, which agrees with the derived photospheric activity (Salabert et al., 2016b). It could actually be the signature of the short-period modulation, or quasi-biennal oscillation, of its magnetic activity as observed in the Sun and the 1-Gyr-old solar analog HD30495. In...

  11. NaturAnalogs for the Unsaturated Zone

    Energy Technology Data Exchange (ETDEWEB)

    A. Simmons; A. Unger; M. Murrell

    2000-03-08

    The purpose of this Analysis/Model Report (AMR) is to document natural and anthropogenic (human-induced) analog sites and processes that are applicable to flow and transport processes expected to occur at the potential Yucca Mountain repository in order to build increased confidence in modeling processes of Unsaturated Zone (UZ) flow and transport. This AMR was prepared in accordance with ''AMR Development Plan for U0135, Natural Analogs for the UZ'' (CRWMS 1999a). Knowledge from analog sites and processes is used as corroborating information to test and build confidence in flow and transport models of Yucca Mountain, Nevada. This AMR supports the Unsaturated Zone (UZ) Flow and Transport Process Model Report (PMR) and the Yucca Mountain Site Description. The objectives of this AMR are to test and build confidence in the representation of UZ processes in numerical models utilized in the UZ Flow and Transport Model. This is accomplished by: (1) applying data from Boxy Canyon, Idaho in simulations of UZ flow using the same methodologies incorporated in the Yucca Mountain UZ Flow and Transport Model to assess the fracture-matrix interaction conceptual model; (2) Providing a preliminary basis for analysis of radionuclide transport at Pena Blanca, Mexico as an analog of radionuclide transport at Yucca Mountain; and (3) Synthesizing existing information from natural analog studies to provide corroborating evidence for representation of ambient and thermally coupled UZ flow and transport processes in the UZ Model.

  12. The Location Algorithm of the Inclined License Plates Based on Mathematical Morphology and Orientation Field

    Institute of Scientific and Technical Information of China (English)

    LIANGDong; GAOJun; CAOWei; FUQizhong; ZHAOJing

    2003-01-01

    The license plate recognition (LPR), as an important measure of traffic controlling and information management, is being paid more and more attention. The location and detection of the inclined license plate is an important problem in the License Plate Recognition Sys-tem. But now most of the proposed location algorithms are based on the condition of the horizontal license. These methods don't work well on inclined license plate. At the same time, the method based on Hough Transform is pro-posed to detect the inclined angle of the license plate, but it has many limitations. In order to solve this problem,we propose a new method to locate the inclined plate region using Mathematical Morphology and Orientation Field. The algorithm consists of preprocessing, inclined an-gel detecting and license plate location modules. Firstly,we adopt the gray extension method to improve the ob-serving quality of the images and study the intrinsic char-acteristic of texture and shape of vehicle license, such as the size, space and height of characters, then we construct the morphologic operator to make a series of morphologicoperations and locate the plate region roughly in the pre-processed image; secondly we make the horizontal and ver-tical projection, get the coordinate of the down left corner and top right corner in the license plate, and detect the inclined angle of the license plate with Orientation Field;lastly, the results of projecting and Orientation Field cal-culating are used to locate the license plate precisely. We practise our method on images under different illumination condition, and the experimental results show that the accu-racy of inclined angel detection and license plate extraction based on Mathematical Morphology and Orientation Field is significant.

  13. Spectrophotometry of (32) Pomona, (145) Adeona, (704) Interamnia, (779) Nina, (330825) 2008 XE3, and 2012 QG42 and laboratory study of possible analog samples

    Science.gov (United States)

    Busarev, Vladimir V.; Barabanov, Sergey I.; Rusakov, Vyacheslav S.; Puzin, Vasiliy B.; Kravtsov, Valery V.

    2015-12-01

    Six asteroids including two NEAs, one of which is PHA, accessible for observation in September 2012 were investigated using a low-resolution (R ≈ 100) spectrophotometry in the range 0.35-0.90 μm with the aim to study features of their reflectance spectra. A high-altitude position of our Terskol Observatory (3150 m above sea level) favorable for the near-UV and visible-range observations of celestial objects allowed us to probably detect some new spectral features of the asteroids. Two subtle absorption bands centered at 0.53 and 0.74 μm were found in the reflectance spectra of S-type (32) Pomona and interpreted as signs of presence of pyroxenes in the asteroid surface matter and its different oxidation. Very similar absorption bands centered at 0.38, 0.44 and 0.67-0.71 μm have been registered in the reflectance spectra of (145) Adeona, (704) Interamnia, and (779) Nina of primitive types. We performed laboratory investigations of ground samples of known carbonaceous chondrites, Orguel (CI), Mighei (CM2), Murchison (CM2), Boriskino (CM2), and seven samples of low-iron Mg serpentines as possible analogs of the primitive asteroids. In the course of this work, we discovered an intense absorption band (up to ∼25%) centered at 0.44 μm in reflectance spectra of the low-Fe serpentine samples. As it turned out, the equivalent width of the band has a high correlation with content of Fe3+ (octahedral and tetrahedral) in the samples. It may be considered as a confirmation of the previously proposed mechanism of the absorption due to electronic transitions in exchange-coupled pairs (ECP) of Fe3+ neighboring cations. It means that the absorption feature can be used as an indicator of ferric iron in oxidized and hydrated low-Fe compounds on the surface of asteroids and other atmosphereless celestial bodies. Moreover, our measurements showed that the mechanism of light absorption is partially or completely blocked in the case of intermediate to high iron contents. Therefore

  14. The future of vitamin D analogs

    Directory of Open Access Journals (Sweden)

    Carlien eLeyssens

    2014-04-01

    Full Text Available The active form of vitamin D3, 1,25-dihydroxyvitamin D3, is a major regulator of bone and calcium homeostasis. In addition, this hormone also inhibits the proliferation and stimulates the differentiation of normal as well as malignant cells. Supraphysiological doses of 1,25-dihydroxyvitamin D3 are required to reduce cancer cell proliferation. However, these doses will lead in vivo to calcemic side effects such as hypercalcemia and hypercalciuria. During the last 25 years, many structural analogs of 1,25-dihydroxyvitamin D3 have been synthesized by the introduction of chemical modifications in the A-ring, central CD-ring region or side chain of 1,25-dihydroxyvitamin D3 in the hope to find molecules with a clear dissociation between the beneficial antiproliferative effects and adverse calcemic side effects. One example of such an analog with a good dissociation ratio is calcipotriol (DaivonexR, which is clinically used to treat the hyperproliferative skin disease psoriasis. Other vitamin D analogs were clinically approved for the treatment of osteoporosis or secondary hyperparathyroidism. No vitamin D analog is currently used in the clinic for the treatment of cancer although several analogs have been shown to be potent drugs in animal models of cancer. Omics studies as well as in vitro cell biological experiments unraveled basic mechanisms involved in the antineoplastic effects of vitamin D and its analogs. 1,25-dihydroxyvitamin D3 and analogs act in a cell type- and tissue-specific manner. Moreover, a blockade in the transition of the G0/1 towards S phase of the cell cycle, induction of apoptosis, inhibition of migration and invasion of tumor cells together with effects on angiogenesis and inflammation have been implicated in the pleiotropic effects of 1,25-dihydroxyvitamin D3 and its analogs. In this review we will give an overview of the action of vitamin D analogs in tumor cells and look forward how these compounds could be introduced in the

  15. Evaluating the Usefulness of Compulsory Licensing in Developing Countries: A Comparative Study of Thai and Brazilian Experiences Regarding Access to Aids Treatments.

    Science.gov (United States)

    Guennif, Samira

    2016-10-04

    While compulsory licensing (CL) is described in the TRIPS agreement as flexibility to protect public health by improving access to medicines in developing countries, a recent literature contends adversely that CL may harm public health. Therefore, this article intends to evaluate the usefulness of CL in the South through the prism of obligations and goals entrusted to patent holders (the effective and non-abusive exploitation of patents in order to achieve industrial and health developments) and in light of experiences in Thailand and Brazil regarding access to antiretroviral drugs. In this way, it shows that the obligations assigned to patent holders were better served by the recipients of CL and brought significant health and industrial benefits in the two high middle-income countries. In particular, CL allowed the scaling-up of free and universal access to antiretroviral drugs by assuring the financial sustainability of these public health programs endangered by monopolistic practices from patent holders.

  16. Musik som analogi og metafor

    DEFF Research Database (Denmark)

    2014-01-01

    Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser......Indeholder underkapitlerne: 2.5.1 Musik som analogi 2.5.2 Musik som metafor 2.5.3 Musikkens psykologiske funktioner - en taxonomi og metaforisk lytning til fire baroksatser...

  17. Fungitoxicity of chemical analogs with heartwood toxins.

    Science.gov (United States)

    Grohs, B M; Kunz, B

    1998-07-01

    Trans-stilbene and tropolone as chemical analogs with naturally occurring fungitoxic heartwood compounds were studied with respect to their fungitoxic potency. While stilbene showed no fungitoxic activity towards the fungi Aureobasidium pullulans var. melanogenum, Penicillium glabrum, and Trichoderma harzianum in the concentrations tested, the minimal inhibiting concentration of tropolone was 10(-3) M for Penicillium glabrum and Trichoderma harzianum, and 10(-5) M for Aureobasidium pullulans var. melanogenum. In all cases, the effect of tropolone was a fungistatic one. Using chemical analogs for assessing the chemical basis of the fungitoxicity of tropolone, this substance proved to be the only compound tested which possesses fungitoxic properties.

  18. Implementing neural architectures using analog VLSI circuits

    Science.gov (United States)

    Maher, Mary Ann C.; Deweerth, Stephen P.; Mahowald, Misha A.; Mead, Carver A.

    1989-05-01

    Analog very large-scale integrated (VLSI) technology can be used not only to study and simulate biological systems, but also to emulate them in designing artificial sensory systems. A methodology for building these systems in CMOS VLSI technology has been developed using analog micropower circuit elements that can be hierarchically combined. Using this methodology, experimental VLSI chips of visual and motor subsystems have been designed and fabricated. These chips exhibit behavior similar to that of biological systems, and perform computations useful for artificial sensory systems.

  19. Using Analogies to Prevent Misconceptions about Chemical Equilibrium

    Science.gov (United States)

    Sahin Pekmez, Esin

    2010-01-01

    The main purpose of this study was to find the effectiveness of using analogies to prevent misconceptions about chemical equilibrium. Nineteen analogies, which were based on dynamic aspects of chemical equilibrium and application of Le Chatelier's principle, were developed. The participations of this study consisted of 11th grade students (n: 151)…

  20. Vehicle License Plate Character Segmentation

    Institute of Scientific and Technical Information of China (English)

    Mei-Sen Pan; Jun-Biao Yan; Zheng-Hong Xiao

    2008-01-01

    Vehicle license plate (VLP) character segmentation is an important part of the vehicle license plate recognition system (VLPRS). This paper proposes a least square method (LSM) to treat horizontal tilt and vertical tilt in VLP images. Auxiliary lines are added into the image (or the tilt-corrected image) to make the separated parts of each Chinese character to be an interconnected region. The noise regions will be eliminated after two fusing images are merged according to the minimum principle of gray values.Then, the characters are segmented by projection method (PM) and the final character images are obtained. The experimental results show that this method features fast processing and good performance in segmentation.

  1. Four Facets of Privacy and Intellectual Freedom in Licensing Contracts for Electronic Journals

    Science.gov (United States)

    Rubel, Alan; Zhang, Mei

    2015-01-01

    This is a study of the treatment of library patron privacy in licenses for electronic journals in academic libraries. We begin by distinguishing four facets of privacy and intellectual freedom based on the LIS and philosophical literature. Next, we perform a content analysis of 42 license agreements for electronic journals, focusing on terms for…

  2. A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230, a multireceptor-targeted somatostatin analog, in healthy volunteers

    Directory of Open Access Journals (Sweden)

    Golor G

    2012-04-01

    Full Text Available Georg Golor1, Ke Hu2, Matthieu Ruffin3, Alexandra Buchelt3, Emmanuel Bouillaud3, Yanfeng Wang2, Mario Maldonado31Parexel International GmbH, Berlin, Germany; 2Novartis Pharmaceuticals, East Hanover, NJ, USA; 3Novartis Pharma AG, Basel, SwitzerlandAbstract: Pasireotide (SOM230 is a multireceptor-targeted somatostatin analog with high binding affinity for four of the five somatostatin receptor subtypes (sst1,2,3 and sst5, and potential clinical activity in several neuroendocrine and oncologic conditions, including acromegaly, Cushing’s disease, and neuroendocrine tumors (NET. This manuscript reports the first-in-man dose-escalation study of pasireotide, evaluating its safety, tolerability, and pharmacokinetics (PK in healthy male volunteers. A single dose of pasireotide 1–1200 µg was administered subcutaneously in four to eight subjects per dose level, with two additional subjects per cohort administered placebo. PK and safety evaluations were carried out over 7 days post-dose. Growth hormone (GH suppression was evaluated using a GH-releasing hormone stimulation test on Day –1 and Day 1 at 3–5 hours post-injection. Seventy-two subjects completed the study. Pasireotide was well tolerated with no serious adverse events observed at any dose. Transient elevations in blood glucose levels were observed 2–6 hours after administration of pasireotide at doses between 200 µg and 1200 µg, but this resolved without intervention by 23 hours post-dosing. The maximum tolerable dose was not established within the tested range. Pasireotide demonstrated a favorable PK profile with fast absorption (tmax: 0.25–0.5 hours, low clearance (CL/F: 8–13 L/hour, long effective elimination half-life (mean t½,ß: 7–11 hours, and a proportional dose-exposure relationship. GH suppression of 79%–96% was observed at single pasireotide doses between 200 µg and 1200 µg. In conclusion, pasireotide demonstrated favorable safety, tolerability, and PK profiles

  3. Distributed Episodic and Analogical Reasoning (DEAR)

    Science.gov (United States)

    2010-04-01

    ends analysis Carbonell 1983 Modeling of Analogy Making Structure Mapping Theory (SMT) Gentner 1984 Agent based approach to analogy making...Mapping Engine (SME) Forbus 1990 Learning by analogy with larger domains Prodigy/Analogy Veloso and Carbonell 1991 Analogical Retrieval Engine MAC/FAC

  4. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel J M

    2010-01-01

    The design of an analog-to-digital converter or digital-to-analog converter is one of the most fascinating tasks in micro-electronics. In a converter the analog world with all its intricacies meets the realm of the formal digital abstraction. Both disciplines must be understood for an optimum conversion solution. In a converter also system challenges meet technology opportunities. Modern systems rely on analog-to-digital converters as an essential part of the complex chain to access the physical world. And processors need the ultimate performance of digital-to-analog converters to present the results of their complex algorithms. The same progress in CMOS technology that enables these VLSI digital systems creates new challenges for analog-to-digital converters: lower signal swings, less power and variability issues. Last but not least, the analog-to-digital converter must follow the cost reduction trend. These changing boundary conditions require micro-electronics engineers to consider their design choices for...

  5. What are the impacts of giving up the driver license?

    DEFF Research Database (Denmark)

    Siren, Anu Kristiina; Haustein, Sonja

    Objectives: Driving cessation is a gradual process, where driver’s self-regulation plays an important role. Age-based license renewal procedures may interfere with this process and trigger premature driving cessation. The present study compares drivers aged 69 years at the baseline who either...... renewed their driver’s license (“renewers”) or did not (“non-renewers”) over a two-year period. Methods: Data were collected by interviewing a sample of older Danish people in 2009 (n = 1,792) and in 2012 (n = 863). The standardized interviews covered respondents’ background information, health and well......-being, and modal choices and transportation patterns. Results: Non-renewers had poorer health already at baseline. However, they did become more dependent on others in their out-of-home activities after giving up their license. In travel frequency, neither the differences between renewers and non-renewers nor...

  6. Chinese license plate character segmentation using multiscale template matching

    Science.gov (United States)

    Tian, Jiangmin; Wang, Guoyou; Liu, Jianguo; Xia, Yuanchun

    2016-09-01

    Character segmentation (CS) plays an important role in automatic license plate recognition and has been studied for decades. A method using multiscale template matching is proposed to settle the problem of CS for Chinese license plates. It is carried out on a binary image integrated from maximally stable extremal region detection and Otsu thresholding. Afterward, a uniform harrow-shaped template with variable length is designed, by virtue of which a three-dimensional matching space is constructed for searching of candidate segmentations. These segmentations are detected at matches with local minimum responses. Finally, the vertical boundaries of each single character are located for subsequent recognition. Experiments on a data set including 2349 license plate images of different quality levels show that the proposed method can achieve a higher accuracy at comparable time cost and is robust to images in poor conditions.

  7. Illusory Licensing Effects across Dependency Types: ERP Evidence

    Science.gov (United States)

    Xiang, Ming; Dillon, Brian; Phillips, Colin

    2009-01-01

    A number of recent studies have argued that grammatical illusions can arise in the process of completing linguistic dependencies, such that unlicensed material is temporarily treated as licensed due to the presence of a potential licensor that is semantically appropriate but in a syntactically inappropriate position. A frequently studied case…

  8. Sulfonimidamide analogs of oncolytic sulfonylureas.

    Science.gov (United States)

    Toth, J E; Grindey, G B; Ehlhardt, W J; Ray, J E; Boder, G B; Bewley, J R; Klingerman, K K; Gates, S B; Rinzel, S M; Schultz, R M; Weir, L C; Worzalla, J F

    1997-03-14

    A series of sulfonimidamide analogs of the oncolytic diarylsulfonylureas was synthesized and evaluated for (1) in vitro cytotoxicity against CEM cells, (2) in vivo antitumor activity against subaxillary implanted 6C3HED lymphosarcoma, and (3) metabolic breakdown to the o-sulfate of p-chloroaniline. The separated enantiomers of one sulfonimidamide analog displayed very different activities in the in vivo screening model. In general, several analogs demonstrated excellent growth inhibitory activity in the 6C3HED model when dosed orally or intraperitoneally. A correlative structure-activity relationship to the oncolytic sulfonylureas was not apparent.

  9. Osilodrostat (LCI699), a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats

    Energy Technology Data Exchange (ETDEWEB)

    Li, Li, E-mail: li1.li@novartis.com [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Vashisht, Kapil; Boisclair, Julie [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Li, Wenkui; Lin, Tsu-han [Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States); Schmid, Herbert A. [Novartis Oncology Development, Basel (Switzerland); Kluwe, William; Schoenfeld, Heidi; Hoffmann, Peter [Preclinical Safety, Novartis Institutes for BioMedical Research, East Hanover, NJ (United States)

    2015-08-01

    The somatostatin analog pasireotide and the 11β-hydroxylase inhibitor osilodrostat (LCI699) reduce cortisol levels by distinct mechanisms of action. There exists a scientific rationale to investigate the clinical efficacy of these two agents in combination. This manuscript reports the results of a toxicology study in rats, evaluating different doses of osilodrostat and pasireotide alone and in combination. Sixty male and 60 female rats were randomized into single-sex groups to receive daily doses of pasireotide (0.3 mg/kg/day, subcutaneously), osilodrostat (20 mg/kg/day, orally), osilodrostat/pasireotide in combination (low dose, 1.5/0.03 mg/kg/day; mid-dose, 5/0.1 mg/kg/day; or high dose, 20/0.3 mg/kg/day), or vehicle for 13 weeks. Mean body-weight gains from baseline to Week 13 were significantly lower in the pasireotide-alone and combined-treatment groups compared to controls, and were significantly higher in female rats receiving osilodrostat monotherapy. Osilodrostat and pasireotide monotherapies were associated with significant changes in the histology and mean weights of the pituitary and adrenal glands, liver, and ovary/oviduct. Osilodrostat alone was associated with adrenocortical hypertrophy and hepatocellular hypertrophy. In combination, osilodrostat/pasireotide did not exacerbate any target organ changes and ameliorated the liver and adrenal gland changes observed with monotherapy. C{sub max} and AUC{sub 0–24h} of osilodrostat and pasireotide increased in an approximately dose-proportional manner. In conclusion, the pasireotide and osilodrostat combination did not exacerbate changes in target organ weight or toxicity compared with either monotherapy, and had an acceptable safety profile; addition of pasireotide to the osilodrostat regimen may attenuate potential adrenal gland hyperactivation and hepatocellular hypertrophy, which are potential side effects of osilodrostat monotherapy. - Highlights: • We examined the target organ toxicity of SOM230

  10. The interplay of conflict and analogy in multidisciplinary teams.

    Science.gov (United States)

    Paletz, Susannah B F; Schunn, Christian D; Kim, Kevin H

    2013-01-01

    Creative teamwork in multidisciplinary teams is a topic of interest to cognitive psychologists on the one hand, and to both social and organizational psychologists on the other. However, the interconnections between cognitive and social layers have been rarely explored. Drawing on mental models and dissonance theories, the current study takes a central variable studied by cognitive psychologists-analogy-and examines its relationship to a central variable examined by social psychologists-conflict. In an observational, field study, over 11h of audio-video data from conversations of the Mars Exploration Rover scientists were coded for different types of analogy and micro-conflicts that reveal the character of underlying psychological mechanisms. Two different types of time-lagged logistic models applied to these data revealed asymmetric patterns of associations between analogy and conflict. Within-domain analogies, but not within-discipline or outside-discipline analogies, preceded science and work process conflicts, suggesting that in multidisciplinary teams, representational gaps in very close domains will be more likely to spark conflict. But analogies also occurred in reaction to conflict: Process and negative conflicts, but not task conflicts, preceded within-discipline analogies, but not to within-domain or outside-discipline analogies. This study demonstrates ways in which cognition can be bidirectionally tied to social processes and discourse.

  11. Reflexivity: Licensing or enforcing

    NARCIS (Netherlands)

    Schadler, D.

    2014-01-01

    During my research I looked at 117 languages and their anaphoric systems. The main goal of this study was to analyse reflexivization, its reasons and effects, by covering cross-linguistic data and by taking into account the variation we find on a macro- and micro-level. To be more precise, throughou

  12. Asserting the primacy of health over patent rights: a comparative study of the processes that led to the use of compulsory licensing in Thailand and Brazil.

    Science.gov (United States)

    Rosenberg, Stephanie T

    2014-08-01

    Since the 1970s, the United States has adopted a trade policy agenda that has forced countries to trade away flexible patent provisions for access to US markets. While pharmaceutical companies have argued that the recognition of patent rights is essential for recovering investments in research and development of pharmaceuticals and incentivizing future innovation, the lack of competition has had damaging consequences for public health, as companies tend to set the prices of treatments beyond the reach of consumers and government programs. Thailand and Brazil are bound by law to provide universal access to anti-retroviral treatment (ART) to People Living with HIV/AIDS (PLWHA). This has been made possible in part due to the universal health care systems in each country and the countries' local technical and industrial capacities that provide the government with affordable generic medicines. The introduction of stronger intellectual property protection laws however, has limited possibilities for procuring generic medicines and inflated the cost of treatment. Between 2006-2008, Thailand and Brazil used compulsory licensing to authorize generic competition against the consent of the pharmaceutical companies in order to guarantee the right to health and ensure the viability of government health budgets. This paper will demonstrate how the interaction between individual / collective action and structural and institutional elements in Thailand and Brazil produced propitious conditions for each country to assert the primacy of health over patent rights.

  13. A Pilot Study of the Effect of a Change in the Scheduling of Canadian Medical Licensing Examinations on Two Cohorts of Students Studying in Ireland

    Directory of Open Access Journals (Sweden)

    Kate Niethammer

    2015-03-01

    Full Text Available Background: The Medical Council of Canada and most Canadian residency programs require international medical graduates seeking training in Ca­nada to pass the Medical Council of Canada Entrance Examination, in addition to the newly established National Collaborative Assessment. In order to facilitate this additional examination, the Medical Council of Canada has altered the suggested examination timeline and examination eligibility criteria. Methods: A cross-sectional survey was sent via an online survey tool to members of the North American Irish Medical Student Association. The survey aimed to elicit differences in the Medical Council of Canada Entrance Examination experience between two cohorts of Canadians studying abroad in Ireland: those who completed the examination before and after the new timeline. Statistical analysis was conducted with independent t-tests and Pearson’s Chi-Square tests using SPSS version 21. Results: Of 24 respondents, 13 had completed the examination after the timeline change. Participants who attended the examination prior to the change achieved higher results (353.8 ± 56.5 than participants who attended the examination after the change (342.3 ± 35.1, although not statistically significant (p=0.56. In the cohort who took the examination after the timeline change, 61.5% of participants expressed discontent with their examination results; 84.6% ‘strongly agreed’ or ‘agreed’ to feeling disadvantaged due to the change. Conclusion: The new Medical Council of Canada examination timeline has had an impact on the examination experience of Canadians studying in Ireland. Simple modifications to the current timeline are warranted to reduce unnecessary disadvantage for this cohort of students applying to postgraduate training in Canada.

  14. Analog CMOS contrastive Hebbian networks

    Science.gov (United States)

    Schneider, Christian; Card, Howard

    1992-09-01

    CMOS VLSI circuits implementing an analog neural network with on-chip contrastive Hebbian learning and capacitive synaptic weight storage have been designed and fabricated. Weights are refreshed by periodic repetition of the training data. To evaluate circuit performance in a medium-sized system, these circuits were used to build a 132 synapse neural network. An adaptive neural system, such as the one described in this paper, can compensate for imperfections in the components from which it is constructed, and thus it is possible to build this type of system using simple, silicon area-efficient analog circuits. Because these analog VLSI circuits are far more compact than their digital counterparts, analog VLSI neural network implementations are potentially more efficient than digital ones.

  15. Solving a problem by analogy

    Science.gov (United States)

    Easton, Don

    1999-03-01

    This note is a description of a student solution to a problem. I found the solution exciting because it exemplifies the kind of solution by analogy that Feynman describes in The Feynman Lectures on Physics.

  16. Analog filters in nanometer CMOS

    CERN Document Server

    Uhrmann, Heimo; Zimmermann, Horst

    2014-01-01

    Starting from the basics of analog filters and the poor transistor characteristics in nanometer CMOS 10 high-performance analog filters developed by the authors in 120 nm and 65 nm CMOS are described extensively. Among them are gm-C filters, current-mode filters, and active filters for system-on-chip realization for Bluetooth, WCDMA, UWB, DVB-H, and LTE applications. For the active filters several operational amplifier designs are described. The book, furthermore, contains a review of the newest state of research on low-voltage low-power analog filters. To cover the topic of the book comprehensively, linearization issues and measurement methods for the characterization of advanced analog filters are introduced in addition. Numerous elaborate illustrations promote an easy comprehension. This book will be of value to engineers and researchers in industry as well as scientists and Ph.D students at universities. The book is also recommendable to graduate students specializing on nanoelectronics, microelectronics ...

  17. “一带一路”沿线省份发明专利实施许可的实证研究%An Empirical Study on Invention Patent Licensing in Provinces along "the Belt and Road" in China

    Institute of Scientific and Technical Information of China (English)

    宋澜; 戚云龙

    2016-01-01

    Purpose/Significance] In order to deeply understand the current situation and problems of technology diffusion in provinces a-long "the Belt and Road", make pointed inter-regional policy support for technology diffusion, and improve overall competitiveness of China in the international technology market. [ Method/Process] This paper utilizes social network analysis method, selects invention pa-tent licensing data in 2015 as research object, analyzes centricity and control force of these provinces in the overall network, and calculates domestic and international influence domains and technology types according to out-degree and in-degree. [ Result/Conclusion] The study finds that provinces along"the Belt and Road" show a"core-margin" distribution in the overall network, that the regional structure of invention patent licensing does not agree with strategic orientation, and some other issues. Then to construct the Technology Poverty Al-leviation Joint Conference, to explore a new"Internet+Patent Licensing" international technology diffusion model, and some other policy suggestions are put forward.%[目的/意义]为深入了解“一带一路”沿线省份技术扩散的现状和问题,从而有针对性地构建跨域技术扩散政策支撑,提升中国在国际技术市场上的整体竞争力。[方法/过程]运用社会网络分析方法,选取2015年中国发明专利许可数据作为研究对象,分析各省份在整体网络中的中心性和控制能力,并分别从出度和入度统计外部、内部发明专利许可影响域和技术类型。[结果/结论]研究发现:“一带一路”沿线省份在整体网络中呈现“核心-边缘”分布,专利许可地域结构与战略导向不一致等问题,提出了建立科技扶贫联席会议、探索“互联网+专利许可”的国际技术扩散模式等建议。

  18. 10 CFR 52.173 - Duration of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Duration of manufacturing license. 52.173 Section 52.173... POWER PLANTS Manufacturing Licenses § 52.173 Duration of manufacturing license. A manufacturing license... issuance. A holder of a manufacturing license may not initiate the manufacture of a reactor less than...

  19. 10 CFR 39.13 - Specific licenses for well logging.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific licenses for well logging. 39.13 Section 39.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Specific Licensing Requirements § 39.13 Specific licenses for well logging. The Commission will approve an application for a specific license for the...

  20. 48 CFR 227.7203-4 - License rights.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License rights. 227.7203-4... Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license. The... license, under an irrevocable license granted or obtained by the contractor which developed the...

  1. 48 CFR 227.7103-4 - License rights.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License rights. 227.7103-4... 227.7103-4 License rights. (a) Grant of license. The Government obtains rights in technical data, including a copyright license, under and irrevocable license granted or obtained for the Government by...

  2. Technology Spillover and Licensing Strategy of Patentee

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The optimal license proportions with and without technology spillover are analyzed with a game-theoretical approach when a patent-holding firm licensed non-drastic process innovation to his incumbent rivals by means of a first price sealed bid auction. The optimal strategy is obtained through solving the game by backward induction. It is found that the range of optimal license proportion is narrower when there is spillover compared to the no spillover case.

  3. Analog electronic neural network circuits

    Energy Technology Data Exchange (ETDEWEB)

    Graf, H.P.; Jackel, L.D. (AT and T Bell Labs., Holmdel, NJ (USA))

    1989-07-01

    The large interconnectivity and moderate precision required in neural network models present new opportunities for analog computing. This paper discusses analog circuits for a variety of problems such as pattern matching, optimization, and learning. Most of the circuits build so far are relatively small, exploratory designs. The most mature circuits are those for template matching. Chips performing this function are now being applied to pattern recognition problems.

  4. Texas site selection and licensing status

    Energy Technology Data Exchange (ETDEWEB)

    Avant, R.V. Jr.

    1989-11-01

    Texas has identified a potential site in Hudspeth County in far West Texas near the town of Fort Hancock. Over the past year the Texas Low-Level Radioactive Waste Disposal Authority has been conducting detailed geology, hydrology, meteorology, soils, and flora and fauna evaluations. An authorization by the Board of Directors of the Authority to proceed with a license application, assuming that the detailed evaluation indicates that the site is suitable, is expected by September. A prototype license has been prepared in anticipation of the order to proceed with licensing, and the formal license application is expected to be submitted to the Texas Department of Health-Bureau of Radiation Control in December, meeting the license application milestone. Although site selection processes in all siting areas across the country have experienced organized opposition, El Paso County has funded a particularly well-organized, well-financed program to legally and technically stop consideration of the Fort Hancock site prior to the licensing process. Many procedural, regulatory, and technical issues have been raised which have required responses from the Authority in order to proceed with licensing. This has provided a unique perspective of what to expect from well-organized opposition at the licensing stage. This paper presents an update on the Texas siting activity with detailed information on the site evaluation and license application. Experience of dealing with issues raised by opposition relating to NRC guidelines and rules is also discussed.

  5. Compulsory licensing of patents in India.

    Science.gov (United States)

    Chaudhry, Rahul

    2016-09-01

    This article deals with compulsory licensing scenarios in India, provides a background of relevant provisions in the Patents Act and examines how these provisions are Trade-Related Aspects of Intellectual Property Rights compliant. This article further discusses the procedure followed by India in granting a compulsory license, provides an overview of compulsory license applications filed in India to date and judicial precedence regarding the same. This article also highlights how compulsory licensing is a great safeguard that balances the interests of the innovators and the public at large.

  6. 76 FR 44939 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2011-07-27

    ... interventional MRI devices. Development Status: Proof of principle has been demonstrated on a prototype device... disease states making Ubl4a an attractive biomarker for the study of disease development or as a tool for...--Research Tool. Patent protection is not being pursued for this technology. Licensing Status:...

  7. The Licensing of Negative Sensitive Items in Jordanian Arabic

    Science.gov (United States)

    Alsarayreh, Atef

    2012-01-01

    This study investigates the licensing conditions on Negative Sensitive Items (NSIs) in Jordanian Arabic (JA). JA exhibits both types of NSIs that are discussed in the literature: Negative Polarity Items (NPIs) and Negative Concord Items (NCIs). Although these two sets of items seem to form a natural class in the sense that they show certain…

  8. 78 FR 42527 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2013-07-16

    ... HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing...: Allows for study of the role of the M3 receptors in the pancreas without whole body effects confounding the results. Development Stage: In vivo data available (animal) Inventor: J rgen Wess, Ph.D....

  9. Licensing process for safety-critical software-based systems

    Energy Technology Data Exchange (ETDEWEB)

    Haapanen, P. [VTT Automation, Espoo (Finland); Korhonen, J. [VTT Electronics, Espoo (Finland); Pulkkinen, U. [VTT Automation, Espoo (Finland)

    2000-12-01

    . Many of the methods and tools needed in the licensing process are still under development and further research is needed to establish a flexible and cost effective process. Also the database for the assessment methods is still inadequate. Other recently published reports in OHA-report series handle the statistical reliability assessment (STUK-YTO-TR 119), usage models (STUK-YTO-TR 128), handling of programmable automation in plant PSA-studies (STUK-YTO-TR 129)and diversity requirements (STUK-YTO-TR 142).(orig.)

  10. Analog approach to mixed analog-digital circuit simulation

    Science.gov (United States)

    Ogrodzki, Jan

    2013-10-01

    Logic simulation of digital circuits is a well explored research area. Most up-to-date CAD tools for digital circuits simulation use an event driven, selective trace algorithm and Hardware Description Languages (HDL), e.g. the VHDL. This techniques enable simulation of mixed circuits, as well, where an analog part is connected to the digital one through D/A and A/D converters. The event-driven mixed simulation applies a unified, digital-circuits dedicated method to both digital and analog subsystems. In recent years HDL techniques have been also applied to mixed domains, as e.g. in the VHDL-AMS. This paper presents an approach dual to the event-driven one, where an analog part together with a digital one and with converters is treated as the analog subsystem and is simulated by means of circuit simulation techniques. In our problem an analog solver used yields some numerical problems caused by nonlinearities of digital elements. Efficient methods for overriding these difficulties have been proposed.

  11. Vehicle License Plate Recognition Syst

    Directory of Open Access Journals (Sweden)

    Meenakshi,R. B. Dubey

    2012-12-01

    Full Text Available The vehicle license plate recognition system has greater efficiency for vehicle monitoring in automatic zone access control. This Plate recognition system will avoid special tags, since all vehicles possess a unique registration number plate. A number of techniques have been used for car plate characters recognition. This system uses neural network character recognition and pattern matching of characters as two character recognition techniques. In this approach multilayer feed-forward back-propagation algorithm is used. The performance of the proposed algorithm has been tested on several car plates and provides very satisfactory results.

  12. 78 FR 78956 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-27

    ...), Xiqian (aka Steven) Wei, President, Application Type: New NVO & OFF License Blue Ocean Logistics... Ocean Transportation Intermediary License Applicants The Commission gives notice that the following applicants have filed an application for an Ocean Transportation Intermediary (OTI) license as a...

  13. 75 FR 66104 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-10-27

    ... Toxicity''. Licensing Status: Available for licensing. Licensing Contact: David A. Lambertson, PhD; 301-435... responses. Blood. 2006 Jun 15;107(12):4597-4605. . 4. Biragyn A, Ruffini PA, Coscia M, Harvey LK, Neelapu...

  14. 76 FR 50216 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2011-08-12

    ... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... corresponding date shown below: License Number: 002364F. Name: Reiko Soejima Gibbs and James Thomas Gibbs...

  15. 76 FR 78007 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2011-12-15

    ... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary license has been revoked pursuant to section... corresponding date shown below: License Number: 018407N. Name: Pacific Atlantic Lines, Inc. Address:...

  16. 76 FR 7210 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2011-02-09

    ... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... corresponding date shown below: License Number: 2226F. Name: Foley, III, William Cody dba Cody...

  17. 76 FR 62408 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2011-10-07

    ... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... corresponding date shown below: License Number: 3105F. Name: CJG International, Inc. Address: 40397 Big Oak...

  18. 76 FR 79682 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2011-12-22

    ... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... corresponding date shown below: License Number: 4365N. Name: Logistics Management International, Inc....

  19. 76 FR 28780 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2011-05-18

    ... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... corresponding date shown below: License Number: 2813F. Name: Vital International Freight Services, Inc....

  20. 77 FR 35386 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2012-06-13

    ... COMMISSION Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... corresponding date shown below: License Number: 018547N. Name: Pallets in Motion. Address: 1140 E....

  1. 77 FR 1937 - Ocean Transportation Intermediary License; Revocation

    Science.gov (United States)

    2012-01-12

    ... Ocean Transportation Intermediary License; Revocation The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... corresponding date shown below: License Number: 018906NF. Name: Tri-Net Logistics Management, Inc. Address:...

  2. 77 FR 42312 - Ocean Transportation Intermediary License; Revocations

    Science.gov (United States)

    2012-07-18

    ... Ocean Transportation Intermediary License; Revocations The Federal Maritime Commission hereby gives notice that the following Ocean Transportation Intermediary licenses have been revoked pursuant to... bond. LICENSE NUMBER: 023327N. NAME: G & F West Indies Shipping, Inc. ADDRESS: 1416 Blue Hill...

  3. 75 FR 41501 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-07-16

    .... Inventors: Shyamasundaran Kottilil (NIAID), Howard Young (NCI), Michael Polis (NIAID), Anthony Suffredini... automation. Inventors: David W. Dorward, Vinod Nair, Elizabeth R. Fischer, Bryan Hansen (NIAID). Patent...-2008/2-PCT-01). Licensing Status: Available for licensing. ] Licensing Contact: Michael Shmilovich,...

  4. Molecular interactions between (--epigallocatechin gallate analogs and pancreatic lipase.

    Directory of Open Access Journals (Sweden)

    Shihui Wang

    Full Text Available The molecular interactions between pancreatic lipase (PL and four tea polyphenols (EGCG analogs, like (--epigallocatechin gallate (EGCG, (--gallocatechin gallate (GCG, (--epicatechin gallate (ECG, and (--epigallocatechin (EC, were studied from PL activity, conformation, kinetics and thermodynamics. It was observed that EGCG analogs inhibited PL activity, and their inhibitory rates decreased by the order of EGCG>GCG>ECG>EC. PL activity at first decreased rapidly and then slowly with the increase of EGCG analogs concentrations. α-Helix content of PL secondary structure decreased dependent on EGCG analogs concentration by the order of EGCG>GCG>ECG>EC. EGCG, ECG, and EC could quench PL fluorescence both dynamically and statically, while GCG only quenched statically. EGCG analogs would induce PL self-assembly into complexes and the hydrodynamic radii of the complexes possessed a close relationship with the inhibitory rates. Kinetics analysis showed that EGCG analogs non-competitively inhibited PL activity and did not bind to PL catalytic site. DSC measurement revealed that EGCG analogs decreased the transition midpoint temperature of PL enzyme, suggesting that these compounds reduced PL enzyme thermostability. In vitro renaturation through urea solution indicated that interactions between PL and EGCG analogs were weak and non-covalent.

  5. All-optical analog comparator

    Science.gov (United States)

    Li, Pu; Yi, Xiaogang; Liu, Xianglian; Zhao, Dongliang; Zhao, Yongpeng; Wang, Yuncai

    2016-08-01

    An analog comparator is one of the core units in all-optical analog-to-digital conversion (AO-ADC) systems, which digitizes different amplitude levels into two levels of logical ‘1’ or ‘0’ by comparing with a defined decision threshold. Although various outstanding photonic ADC approaches have been reported, almost all of them necessitate an electrical comparator to carry out this binarization. The use of an electrical comparator is in contradiction to the aim of developing all-optical devices. In this work, we propose a new concept of an all-optical analog comparator and numerically demonstrate an implementation based on a quarter-wavelength-shifted distributed feedback laser diode (QWS DFB-LD) with multiple quantum well (MQW) structures. Our results show that the all-optical comparator is very well suited for true AO-ADCs, enabling the whole digital conversion from an analog optical signal (continuous-time signal or discrete pulse signal) to a binary representation totally in the optical domain. In particular, this all-optical analog comparator possesses a low threshold power (several mW), high extinction ratio (up to 40 dB), fast operation rate (of the order of tens of Gb/s) and a step-like transfer function.

  6. Personality Factors and Nuclear Power Plant Operators: Initial License Success

    Science.gov (United States)

    DeVita-Cochrane, Cynthia

    Commercial nuclear power utilities are under pressure to effectively recruit and retain licensed reactor operators in light of poor candidate training completion rates and recent candidate failures on the Nuclear Regulatory Commission (NRC) license exam. One candidate failure can cost a utility over $400,000, making the successful licensing of new operators a critical path to operational excellence. This study was designed to discover if the NEO-PI-3, a 5-factor measure of personality, could improve selection in nuclear utilities by identifying personality factors that predict license candidate success. Two large U.S. commercial nuclear power corporations provided potential participant contact information and candidate results on the 2014 NRC exam from their nuclear power units nation-wide. License candidates who participated (n = 75) completed the NEO-PI-3 personality test and results were compared to 3 outcomes on the NRC exam: written exam, simulated operating exam, and overall exam result. Significant correlations were found between several personality factors and both written and operating exam outcomes on the NRC exam. Further, a regression analysis indicated that personality factors, particularly Conscientiousness, predicted simulated operating exam scores. The results of this study may be used to support the use of the NEO-PI-3 to improve operator selection as an addition to the current selection protocol. Positive social change implications from this study include support for the use of a personality measure by utilities to improve their return-on-investment in candidates and by individual candidates to avoid career failures. The results of this study may also positively impact the public by supporting the safe and reliable operation of commercial nuclear power utilities in the United States.

  7. 32 CFR 643.126 - Transportation licenses.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Transportation licenses. 643.126 Section 643.126... ESTATE Additional Authority of Commanders § 643.126 Transportation licenses. Installation commanders are... free competitive proposals of all available companies or individuals. (b) DD Form 694...

  8. 76 FR 32866 - Cable Landing Licenses; Correction

    Science.gov (United States)

    2011-06-07

    ... Systems Agency in the regulations that we published in the Federal Register of January 14, 2002, 67 FR... COMMISSION 47 CFR Part 1 Cable Landing Licenses; Correction AGENCY: Federal Communications Commission. ACTION... streamlined processing of cable landing license applications. Need for Correction As published, the...

  9. Licensing failure in the European decentralised procedure

    NARCIS (Netherlands)

    Langedijk, Joris; Ebbers, Hans C; Mantel-Teeuwisse, Aukje K; Kruger-Peters, Alexandra G; Leufkens, Hubert G M

    2016-01-01

    The majority of the licensing applications in the European Union are submitted via the decentralised procedure. Little is known about licensing failure (i.e. refusal or withdrawal of a marketing authorisation application) in the EU decentralised procedure compared to the EU centralised procedure and

  10. 24 CFR 244.2 - License.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false License. 244.2 Section 244.2 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF... FOR GROUP PRACTICE FACILITIES Eligibility Requirements § 244.2 License. The Commissioner shall...

  11. Overdragelse af immaterielle licenser ved virksomhedsoverdragelser

    DEFF Research Database (Denmark)

    Liin, Birgit; Bülow, Christian

    2012-01-01

    Artiklen belyser mulighederhne for at overdrage immaterielle licenser i forbindelse med virksomhedsoverdragelser i og uden for konkurs, herunder med hjemmel i konkuslovens § 14 c, stk. 2, fra virksomheder under rekonstruktionsbehandling.......Artiklen belyser mulighederhne for at overdrage immaterielle licenser i forbindelse med virksomhedsoverdragelser i og uden for konkurs, herunder med hjemmel i konkuslovens § 14 c, stk. 2, fra virksomheder under rekonstruktionsbehandling....

  12. China Unicom obtained Macao 3G license

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Macao Telecommunications Administration announced the competitive tender result of 3G license yesterday. There had 5 telecom operators bidding 3 licenses, China Unicom (Macao), Hutchison Telephone (Macao) and CTM won their bids. The other two tender are DIGI and Kong Seng.

  13. 36 CFR 271.4 - Commercial license.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Commercial license. 271.4 Section 271.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE USE OF âSMOKEY BEARâ SYMBOL § 271.4 Commercial license. (a) The Chief may authorize the commercial...

  14. Your EHR license agreement: critical issues.

    Science.gov (United States)

    Shay, Daniel F

    2014-01-01

    This article discusses several key provisions and concepts in software license agreements for electronic health records. It offers insight into what physician practices can expect to find in their license agreements, as well as practical advice on beneficial provisions. The article examines contractual language relating to term and termination, technical specifications and support, and compliance with governmental programs.

  15. 24 CFR 232.2 - License.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false License. 232.2 Section 232.2... Eligibility Requirements § 232.2 License. The Commissioner shall not insure any mortgage under this part... facility is or is to be located, and the appropriate agency for such jurisdiction provides a...

  16. NEG-shift, Licensing, and Repair Strategies

    DEFF Research Database (Denmark)

    Christensen, Ken Ramshøj

    2008-01-01

    I entertain the idea that the cross-linguistic variation in the licensing of NEG-shift, the movement of negative objects to spec-NegP, can be accounted for by a few representational constraints that are not directly related to case licensing or feature checking, and which potentially conflict wit...

  17. License - DMPD | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us DMPD Lice... terms and conditions of the Standard License and the Additional License described below. The Standard License specifies the lice...ments you must follow in using this database. The Additional License specifies those items that are exceptio...nally permitted even though they are generally prohibited in the Standard License. Standard License The Standard Lice...nse for this database is the license specified in the Creative Commons A

  18. 42 CFR 431.709 - Issuance and revocation of license.

    Science.gov (United States)

    2010-10-01

    ... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION State Programs for Licensing Nursing Home Administrators § 431.709 Issuance and revocation of license. Except...

  19. Test Wiseness and Analogy Test Performance

    Science.gov (United States)

    Moore, James C.

    1971-01-01

    Subjects received self instruction on how to approach analogy questions. Instruction was directed toward knowledge of the general format of analogy questions in standarized tests and the 15 types of relationships commonly asked for in analogy questions. An analogies post-test showed a significant effect for the group. (Author)

  20. Analog electronics for radiation detection

    CERN Document Server

    2016-01-01

    Analog Electronics for Radiation Detection showcases the latest advances in readout electronics for particle, or radiation, detectors. Featuring chapters written by international experts in their respective fields, this authoritative text: Defines the main design parameters of front-end circuitry developed in microelectronics technologies Explains the basis for the use of complementary metal oxide semiconductor (CMOS) image sensors for the detection of charged particles and other non-consumer applications Delivers an in-depth review of analog-to-digital converters (ADCs), evaluating the pros and cons of ADCs integrated at the pixel, column, and per-chip levels Describes incremental sigma delta ADCs, time-to-digital converter (TDC) architectures, and digital pulse-processing techniques complementary to analog processing Examines the fundamental parameters and front-end types associated with silicon photomultipliers used for single visible-light photon detection Discusses pixel sensors ...

  1. Analog-digital codesign using coarse quantization

    Science.gov (United States)

    Kokkeler, Andre Bernardus Joseph

    With regards to electronic systems, two important trends can be observed. The first trend is generally known as Moore's law: the digital processing capacity per chip is increasing a factor two every 18 months. Another part of the first trend is that the performance increase of integrated linear or analog processing is slow, a factor two every 4.7 years. The second trend is that the rate of data exchange between electronic systems is increasing rapidly. Because of these high data rates especially the design of data converters from analog to digital (ADCs) is demanding. For a specific set of applications, the requirements for the ADC can be relaxed by reducing the resolution of the conversion from analog to digital. Within these specific applications, signal characteristics rather than instantaneous values of the signal are determined. Reducing the resolution to an extreme extend is called 'coarse quantization'. The design of mixed signal systems is guided by a Y-chart design methodology. Analog-Digital Codesign, guided by the Y-chart approach, leads to mixed-signal systems with reduced costs compared to systems designed with the traditional methodology. The Y-chart approach also enables the use of coarse quantization as an additional design parameter to further reduce costs. This is illustrated by two case studies. The first case study concentrates on the design of a digital predistorter for Power Amplifiers (PAs) in telecommunication transmitters. In the second case study, we reconsider the design of a part of a Radio Telescope, used for Radio Astronomy. This part is called the Tied Array Adder and it sums signals from different telescopes. Both case studies show that coarse quantization can lead to mixed-signal systems with lower costs but system parameters will change. The explicit reconsideration of functional specifications, facilitated by the Y-chart approach, is therefore essential for the introduction of coarse quantization.

  2. An examination of the perceived teaching competencies of novice alternatively licensed and traditionally licensed high school science teachers

    Science.gov (United States)

    Shea, Kathleen A.

    In most states, there are two routes to teacher licensure; traditional and alternative. The alternative route provides an accelerated entry into the classroom, often without the individual engaging in education coursework or a practicum. No matter the route, teaching skills continue to be learned by novice teachers while in the classroom with the guidance of a school-based mentor. In this study, the perceptions of mentor teachers of traditionally and alternatively licensed high school science teachers were compared with respect to mentees' science teaching competency. Further, the study explored the novice teachers' self-perception of their teaching competency. A survey, consisting of 56 Likert-type questions, was completed by mentors (N = 79) and novice high school science teachers (N = 83) in six northeastern states. The results revealed a statistically significant difference in the perceptions of the mentors of traditionally and alternatively licensed novice high school science teachers in the areas of general pedagogical knowledge, pedagogical content knowledge and professional growth, with more favorable perceptions recorded by mentors of traditionally licensed science teachers. There were no differences in the perceptions of the mentors with respect to novice high school teachers' content knowledge. There was no statistical difference in the self-perceptions of competency of the novice teachers. While alternative routes to licensure in science may be a necessity, the results of this study indicate that the lack of professional preparation may need to be addressed at the school level through the agency of the mentor. This study indicates that mentors must be prepared to provide alternatively licensed novice teachers with different assistance to that given to traditionally licensed novice teachers. School districts are urged to develop mentoring programs designed to develop the teaching competency of all novice teachers regardless of the route that led them

  3. All-optical analog comparator

    OpenAIRE

    Pu Li; Xiaogang Yi; Xianglian Liu; Dongliang Zhao; Yongpeng Zhao; Yuncai Wang

    2016-01-01

    An analog comparator is one of the core units in all-optical analog-to-digital conversion (AO-ADC) systems, which digitizes different amplitude levels into two levels of logical ‘1’ or ‘0’ by comparing with a defined decision threshold. Although various outstanding photonic ADC approaches have been reported, almost all of them necessitate an electrical comparator to carry out this binarization. The use of an electrical comparator is in contradiction to the aim of developing all-optical device...

  4. NASA HRP Immunology Discipline - Use of Terrestrial Analogs

    Science.gov (United States)

    Crucian, Brian

    2014-01-01

    Due to the cost and operational constraints, as well as technical implementation limitations, it is desirous to perform relevant space physiology investigations first in terrestrial 'space analogs'. This is particularly true for initial investigations, which may then provide appropriate focus for subsequent flight investigations, or for mechanistic investigations that simply cannot be performed during spaceflight. Appropriate analog choice is extremely important. There are a wide variety of terrestrial space analogs, each relevant to a particular physiological discipline (or disciplines) and each with a particular fidelity (or lack thereof) to spaceflight, and each with unique operational constraints. The HRP Immunology Discipline is tasked with managing the HRP Risk concerning clinical risk for Astronaut crews related to spaceflight-associated immune dysregulation. Such dysregulation has been documented to occur during spaceflight, and found to persist for the duration of a 6-month ISS mission. Studies continue to characterize the onorbit phenomenon, but it generally consists of diminished immunocyte function, dysregulated cytokine profiles, and persistent herpesvirus reactivation. Causes are thought to synergistically include microgravity, psychological or physiological stress, radiation, and/or circadian misalignment. An appropriate terrestrial analog for immune dysregulation would replicate as many of these influences as possible. Such analogs may include clinostat or bioreactor cell culture (microgravity), hindlimb suspension (stress, fluid shifts, hypokinesis), or human deployment to remote or extreme environments (isolation, stress, circadian). Also, the laboratory setting may be used as an analog, or to augment analogs, such as sleep deprivation/misalignment or human centrifugation to replicate gravitational stress. As an appropriate example of a NASA Disciplines use of Terrestrial space analogs, this talk will discuss spaceflight associated immune

  5. A new program on digitizing analog seismograms

    Science.gov (United States)

    Wang, Maofa; Jiang, Qigang; Liu, Qingjie; Huang, Meng

    2016-08-01

    Historical seismograms contain a great variety of useful information which can be used in the study of earthquakes. It is necessary for researchers to digitize analog records and extract the information just as modern computing analysis requires. Firstly, an algorithm based on color scene filed method is presented in order to digitize analog seismograms. Secondly, an interactive software program using C# has been developed to digitize seismogram traces from raster files quickly and accurately. The program can deal with gray-scale images stored in a suitable file format and it offers two different methods: manual digitization and automatic digitization. The test result of the program shows that the methods presented in this paper can lead to good performance.

  6. Mathematical Analogy and Metaphorical Insight

    Science.gov (United States)

    Zwicky, Jan

    2010-01-01

    How are we to understand the power of certain literary metaphors? The author argues that the apprehension of good metaphors is importantly similar to the apprehension of fruitful mathematical analogies: both involve a structural realignment of vision. The author then explores consequences of this claim, drawing conceptually significant parallels…

  7. Geometrical Analogies in Mathematics Lessons

    Science.gov (United States)

    Eid, Wolfram

    2007-01-01

    A typical form of thinking to approach problem solutions humanly is thinking in analogous structures. Therefore school, especially mathematical lessons should help to form and to develop corresponding heuristic abilities of the pupils. In the contribution, a summary of possibilities of mathematics lessons regarding this shall particularly be…

  8. Schema Training in Analogical Reasoning.

    Science.gov (United States)

    Robins, Shani; Mayer, Richard E.

    1993-01-01

    In 3 experiments, 93, 97, and 86 college students, respectively, learned how to solve 20 verbal analogy problems and took transfer and memory tests. Results are inconsistent with active responding theory and further indicate that schema induction is maximized when the schemas are made salient and the cognitive system is not overloaded. (SLD)

  9. 49205 ANALOGE OG DIGITALE FILTRE

    DEFF Research Database (Denmark)

    Gaunholt, Hans

    1997-01-01

    Theese lecture notes treats the fundamental theory and the most commonly used design methods for passive- active and digital filters with special emphasis on microelectronic realizations. The lecture notes covers 75% of the material taught in the course 49205 Analog and Digital Filters...

  10. Analog Input Data Acquisition Software

    Science.gov (United States)

    Arens, Ellen

    2009-01-01

    DAQ Master Software allows users to easily set up a system to monitor up to five analog input channels and save the data after acquisition. This program was written in LabVIEW 8.0, and requires the LabVIEW runtime engine 8.0 to run the executable.

  11. International Alligator Rivers Analog Project

    Energy Technology Data Exchange (ETDEWEB)

    Bichard, G.F.

    1988-01-01

    The Australian Nuclear Science and Technology Organization (ANSTO), the Japan Atomic Energy Research Institute, the Swedish Nuclear Power Inspectorate, the U.K. Department of the Environment, the US Nuclear Regulatory Commission (NRC), and the Power Reactor and Nuclear Fuel Development Corporation of Japan are participating under the aegis of the Nuclear Energy Agency in the International Alligator Rivers Analog Project. The project has a duration of 3 yr, starting in 1988. The project has grown out of a research program on uranium ore bodies as analogs of high-level waste (HLW) repositories undertaken by ANSTO supported by the NRC. A primary objective of the project is to develop an approach to radionuclide transport model validation that may be used by the participants to support assessments of the safety of radioactive waste repositories. The approach involves integrating mathematical and physical modeling with hydrological and geochemical field and laboratory investigations of the analog site. The Koongarra uranium ore body has been chosen as the analog site because it has a secondary ore body that has formed over the past million years as a result of leaching by groundwater flowing through fractures in the primary ore body.

  12. The Effects of Analogies and Mathematics Ability on Students' Programming Learning Using Computer-Based Learning.

    Science.gov (United States)

    Lai, Shu-Ling; Repman, Judith L.

    1996-01-01

    Purposes of this study were to determine: (1) if analogies and elaboration and placement of the analogies help novices learning a computer-programming language; (2) if students' mathematics ability influences programming learning; and (3) the interaction effects between analogy and mathematics ability. Subjects were 156 college students. Results…

  13. Analog Filter Design Rules for Multilevel Polybinary Signaling Generation

    DEFF Research Database (Denmark)

    Vegas Olmos, Juan José; Cavallero, Francisco javier Vaquero; Tafur Monroy, Idelfonso

    2014-01-01

    Polybinary signaling has gained attention lately due to its generation simplicity and reduced spectral usage. This paper presents a study on the requirements for analog filters for the generation of multilevel polybinary signals with three to nine levels.......Polybinary signaling has gained attention lately due to its generation simplicity and reduced spectral usage. This paper presents a study on the requirements for analog filters for the generation of multilevel polybinary signals with three to nine levels....

  14. Braneworld physics from the analog-gravity perspective

    CERN Document Server

    Barcelo, C; Barcelo, Carlos; Campos, Antonio

    2003-01-01

    We study Randall-Sundrum brane models from the viewpoint of condensed matter/quantum optics. Following the idea of analog gravity we obtain effective metrics in fluid and Bose-Einstein-condensate systems mimicking those in the brane framework. We see that the effect of warp factors in the bulk geometry translates into finite-size of the analog systems. We stress that many open questions in braneworld physics can benefit from the understanding of critical phenomena of surfaces in finite analog systems.

  15. Inhibition of a plant virus infection by analogs of melittin.

    Science.gov (United States)

    Marcos, J F; Beachy, R N; Houghten, R A; Blondelle, S E; Pérez-Payá, E

    1995-01-01

    An approach that enables identification of specific synthetic peptide inhibitors of plant viral infection is reported. Synthetic analogs of melittin that have sequence and structural similarities to an essential domain of tobacco mosaic virus coat protein were found to possess highly specific antiviral activity. This approach involves modification of residues located at positions analogous to those that are critical for virus assembly. The degree of inhibition found correlates well with sequence similarities between the viral capsid protein and the melittin analogs studied as well as with the induced conformational changes that result upon interaction of the peptides and ribonucleic acid. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:8618922

  16. Study of G-S/D underlap for enhanced analog performance and RF/circuit analysis of UTB InAs-OI-Si MOSFET using NQS small signal model

    Science.gov (United States)

    Maity, Subir Kumar; Pandit, Soumya

    2017-01-01

    InGaAs (and its variant) appears to be a promising channel material for high-performance, low-power scaled CMOS applications due to its excellent carrier transport properties. However, MOS transistors made of this suffer from poor electrostatic integrity. In this work, we consider an underlap ultra thin body (UTB) InAs-on-Insulator n-channel MOS transistor, and study the effect of varying the gate-source/drain (G-S/D) underlap length on the analog performance of the device with the help of technology computer-aided design (TCAD) simulation, calibrated with Schrodinger-Poisson solver and experimental results. The underlap technique improves the gate electrostatic integrity which in turn improves the analog performance. We develop a non-quasi-static (NQS) small signal equivalent circuit model of the device which is used for study of the RF performance. With increase of the underlap length, the unity gain cut-off frequency degrades and the maximum oscillation frequency improves beyond a certain value of the underlap length. We further study the gain-frequency response of a common source amplifier using the NQS model, through SPICE simulation and observe that the voltage gain and the gain bandwidth improves.

  17. Studies of Spin-Liquid and Analog to Helium-4 Melting Curve in a 3D Frustrated Magnet: Gd3Ga5O12

    Science.gov (United States)

    Tsui, Y. K.

    2000-03-01

    Gadolinium gallium garnet, Gd_3Ga_5O_12 (GGG) has an extraordinary low temperature phase diagram [1,2]. Although the Curie-Weiss temperature of GGG is ~ -2 K, GGG shows no long range order down to T ~ 0.4 K. At low temperatures, GGG has a spin glass phase at low fields (properties of the intermediate field (IF) state through heat capacity, thermal conductivity, and magnetocaloric measurements [3]. Our results show a sharp high-field phase boundary of the thermal irreversibility of the spin glass phase of GGG implying that the IF phase is distinct from the spin glass. The lower field boundary of the AFM phase is shown to have distinct minimum at T ~ 0.2 K, in analogy to the minimum in the melting curve of ^4He. The existence of such a minimum is confirmed by measurements of the latent heat of the transition below that temperature and is consistent with our heat capacity data. Currently we are measuring the dc magnetization (M) of GGG. Our preliminary data confirm the clear boundary between the spin glass and the IF states. M also shows indications of the reentrance of the IF phase. [1] P. Schiffer et al., Phys. Rev. Lett. 73, 2500 (1994). [2] P. Schiffer et al., Phys. Rev. Lett. 74, 2379 (1995). [3] Y.K. Tsui et al., Phys. Rev. Lett. 82, 3532 (1999).

  18. Folding model study of the charge-exchange scattering to the isobaric analog state and implication for the nuclear symmetry energy

    CERN Document Server

    Khoa, Dao T; Thang, Dang Ngoc

    2013-01-01

    The Fermi transition (\\Delta L=\\Delta S=0 and \\Delta T=1) between the nuclear isobaric analog states (IAS), induced by the charge-exchange (p,n) or (3He,t) reaction, can be considered as "elastic" scattering of proton or 3He by the isovector term of the optical potential (OP) that flips the projectile isospin. The accurately measured (p,n) or (3He,t) scattering cross-section to the IAS can be used, therefore, to probe the isospin dependence of the proton or 3He optical potential. Within the folding model, the isovector part of the OP is determined exclusively by the neutron-proton difference in the nuclear densities and the isospin dependence of the effective nucleon-nucleon (NN) interaction. Because the isovector coupling explicitly links the isovector part of the proton or 3He optical potential to the cross section of the charge-exchange (p,n) or (3He,t) scattering to the IAS, the isospin dependence of the effective (in-medium) NN interaction can be well tested in the folding model analysis of these charge-...

  19. 10 CFR 52.109 - Continuation of combined license.

    Science.gov (United States)

    2010-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.109 Continuation of combined license. Each combined license for a... continue to maintain the facility, including, where applicable, the storage, control and maintenance of...

  20. 10 CFR 51.54 - Environmental report-manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Environmental report-manufacturing license. 51.54 Section... report—manufacturing license. (a) Each applicant for a manufacturing license under subpart F of part 52... Environmental Report—Manufacturing License.” The environmental report must address the costs and benefits...

  1. 10 CFR 52.175 - Transfer of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Transfer of manufacturing license. 52.175 Section 52.175 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Manufacturing Licenses § 52.175 Transfer of manufacturing license. A manufacturing...

  2. 10 CFR 52.167 - Issuance of manufacturing license.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Issuance of manufacturing license. 52.167 Section 52.167... POWER PLANTS Manufacturing Licenses § 52.167 Issuance of manufacturing license. (a) After completing any... manufacturing license if the Commission finds that: (1) Applicable standards and requirements of the Act and...

  3. 75 FR 60124 - Ocean Transportation Intermediary License Revocations

    Science.gov (United States)

    2010-09-29

    .... LICENSE NUMBER: 019206NF. NAME: Fun N Stuff International USA, Inc. dba Air Ocean Land Transport Logistics...: Surrendered license voluntarily. LICENSE NUMBER: 020934N. NAME: D.L. International Logistics Inc. ADDRESS... corresponding date shown below: LICENSE NUMBER: 003555F. NAME: Thomas Griffin International, Inc. ADDRESS:...

  4. 78 FR 79018 - Request for a License To Export Deuterium

    Science.gov (United States)

    2013-12-27

    ... COMMISSION Request for a License To Export Deuterium Pursuant to 10 CFR 110.70 (b) ``Public Notice of Receipt... received the following request for an export license. Copies of the request are available electronically.... The information concerning this export license application follows. ] NRC Export License...

  5. 7 CFR 6.32 - Globalization of licenses.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Globalization of licenses. 6.32 Section 6.32 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES Dairy Tariff-Rate Import Quota Licensing § 6.32 Globalization of licenses. If the Licensing Authority determines that entries of an...

  6. 76 FR 7210 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2011-02-09

    ... Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary license has been reissued by the Federal Maritime Commission pursuant to section 19... to the licensing of Ocean Transportation Intermediaries, 46 CFR part 515. License No....

  7. 77 FR 13605 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2012-03-07

    ... Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary licenses have been reissued by the Federal Maritime Commission pursuant to section 19... to the licensing of Ocean Transportation Intermediaries, 46 CFR Part 515. License no....

  8. 48 CFR 252.227-7004 - License grant.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License grant. 252.227... Clauses 252.227-7004 License grant. As prescribed at 227.7009-3(a), insert the following clause in patent releases, license agreements, and assignments: License Grant (AUG 1984) (a) The Contractor hereby grants...

  9. 76 FR 30360 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-05-25

    ...] [FR Doc No: 2011-12969] FEDERAL MARITIME COMMISSION Ocean Transportation Intermediary License... Commission an application for a license as a Non-Vessel-Operating Common Carrier (NVO) and/or Ocean Freight... applications to amend an existing OTI license or the Qualifying Individual (QI) for a license....

  10. 76 FR 16421 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2011-03-23

    ... Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary licenses have been reissued by the Federal Maritime Commission pursuant to section 19... to the licensing of Ocean Transportation Intermediaries, 46 CFR part 515. License No....

  11. 48 CFR 252.227-7005 - License term.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false License term. 252.227-7005... Clauses 252.227-7005 License term. As prescribed at 227.7009-3(b), insert one of the following clauses in patent releases, license agreements, and assignments: License Term (OCT 2001) Alternate I (AUG 1984)....

  12. 77 FR 1937 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2012-01-12

    ... Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary licenses have been reissued by the Federal Maritime Commission pursuant to section 19... to the licensing of Ocean Transportation Intermediaries, 46 CFR part 515. License No....

  13. 76 FR 28779 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2011-05-18

    ... Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary licenses have been reissued by the Federal Maritime Commission pursuant to section 19... to the licensing of Ocean Transportation Intermediaries, 46 CFR part 515. License No....

  14. 76 FR 50216 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2011-08-12

    ... Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary licenses have been reissued by the Federal Maritime Commission pursuant to section 19... to the licensing of Ocean Transportation Intermediaries, 46 CFR part 515. License No....

  15. 76 FR 76411 - Ocean Transportation Intermediary License; Reissuance

    Science.gov (United States)

    2011-12-07

    ... Ocean Transportation Intermediary License; Reissuance Notice is hereby given that the following Ocean Transportation Intermediary licenses have been reissued by the Federal Maritime Commission pursuant to section 19... to the licensing of Ocean Transportation Intermediaries, 46 CFR part 515. ] License No....

  16. 7 CFR 51.35 - Surrender of license.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Surrender of license. 51.35 Section 51.35 Agriculture... Licensing of Inspectors § 51.35 Surrender of license. Upon termination of his services as a licensed... the office of inspection serving the area in which he is located. These same provisions shall apply...

  17. eeDAP: an evaluation environment for digital and analog pathology

    Science.gov (United States)

    Gallas, Brandon D.; Cheng, Wei-Chung; Gavrielides, Marios A.; Ivansky, Adam; Keay, Tyler; Wunderlich, Adam; Hipp, Jason; Hewitt, Stephen M.

    2014-03-01

    Purpose: The purpose of this work is to present a platform for designing and executing studies that compare pathologists interpreting histopathology of whole slide images (WSI) on a computer display to pathologists interpreting glass slides on an optical microscope. Methods: Here we present eeDAP, an evaluation environment for digital and analog pathology. The key element in eeDAP is the registration of theWSI to the glass slide. Registration is accomplished through computer control of the microscope stage and a camera mounted on the microscope that acquires images of the real time microscope view. Registration allows for the evaluation of the same regions of interest (ROIs) in both domains. This can reduce or eliminate disagreements that arise from pathologists interpreting different areas and focuses the comparison on image quality. Results: We reduced the pathologist interpretation area from an entire glass slide (≈10-30 mm)2 to small ROIs google.com (project: eeDAP) as Matlab source or as a precompiled stand-alone license-free application.

  18. Analog circuit design art, science and personalities

    CERN Document Server

    Williams, Jim

    1991-01-01

    This book is far more than just another tutorial or reference guide - it's a tour through the world of analog design, combining theory and applications with the philosophies behind the design process. Readers will learn how leading analog circuit designers approach problems and how they think about solutions to those problems. They'll also learn about the `analog way' - a broad, flexible method of thinking about analog design tasks.A comprehensive and useful guide to analog theory and applications. Covers visualizing the operation of analog circuits. Looks at how to rap

  19. 7 CFR 46.6 - License fees.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE MARKETING OF PERISHABLE AGRICULTURAL COMMODITIES REGULATIONS (OTHER THAN RULES OF PRACTICE) UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT, 1930 Licenses § 46.6...

  20. 7 CFR 46.3 - License required.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE MARKETING OF PERISHABLE AGRICULTURAL COMMODITIES REGULATIONS (OTHER THAN RULES OF PRACTICE) UNDER THE PERISHABLE AGRICULTURAL COMMODITIES ACT, 1930 Licenses § 46.3...

  1. Licensing Opportunities for NIH, CDC & FDA Technologies

    Data.gov (United States)

    U.S. Department of Health & Human Services — This dataset represents all technologies available for licensing from the National Institutes of Health (NIH), the Food and Drug Administration (FDA), and the Center...

  2. 36 CFR 25.2 - License.

    Science.gov (United States)

    2010-07-01

    ... desire a shortened tour, to arrange for such service as may suit their convenience. 8. (a) Not to operate... motor vehicle operator's license issued by the State in which the national military park is located....

  3. Whom to Choose as License Partner?

    DEFF Research Database (Denmark)

    Laursen, Keld; Reichstein, Toke; Trombini, Giulia

    2013-01-01

    This paper investigates the matching of firms on the market for technology. The paper forwards two dimensions along which license formation occurs: technology and product-market. Both sides of the market search for a partner representing potential for high technology synergies to maximize licensing...... benefits and obviate issues related to technology transfer and knowledge recombination. At the same time, firms wish to select a partner operating in a different product market to minimize competitive downside issues and to access other product markets, skills and resources. We contend interdependence...... between technology and market forces: if partners are market distant, the likelihood of technology license contractual partnership decreases with partners’ technological distance. Using data on the formation of license partnerships in the global biopharmaceutical industry over the period 1994...

  4. 78 FR 17450 - Notice of Issuance of Materials License Renewal, Operating License SUA-1341, Uranium One USA, Inc...

    Science.gov (United States)

    2013-03-21

    ... COMMISSION Notice of Issuance of Materials License Renewal, Operating License SUA-1341, Uranium One USA, Inc., Willow Creek Uranium In Situ Recovery Project AGENCY: Nuclear Regulatory Commission. ACTION: Notice of... license renewal for Materials License No. SUA- 1341 to Uranium One USA, Inc. (Uranium One) for its...

  5. 77 FR 13376 - Notice of License Termination for the University of Arizona Research Reactor, License No. R-52

    Science.gov (United States)

    2012-03-06

    ... COMMISSION Notice of License Termination for the University of Arizona Research Reactor, License No. R-52 The... No. R-52, for the University of Arizona Research Reactor (UARR). The NRC has terminated the license... released for unrestricted use. Therefore, Facility Operating License No. R-52 is terminated. For...

  6. 78 FR 12365 - License Amendment Request for United Nuclear Corporation, Church Rock Mill-License No. SUA-1475

    Science.gov (United States)

    2013-02-22

    ... COMMISSION License Amendment Request for United Nuclear Corporation, Church Rock Mill--License No. SUA-1475... Materials License Number SUA-1475 for the UNC Church Rock Mill site located in New Mexico (the UNC license... flow model for the UNC Church Rock Mill site and adjacent downgradient areas . In a letter...

  7. Chemical and physical effects in the bulk of cometary analogs

    Science.gov (United States)

    Roessler, K.; Benit, Jean; Sauer, M.

    1992-01-01

    KOSI comet simulation experiments were designed as a macroscopic tester for the studies of physicochemical problems inherent to comet bodies. The analog samples consist of H2O and CO2 ice, organic admixtures, mineral dust, and carbon. Two of the fundamental changes the analogs undergo when submitted to 'insolation' by artificial sunlight, i.e., the diffusion of frozen gases and subsequent crust formation and the natural isotopic fractionation, are reported.

  8. Holism and nonseparability by analogy

    Science.gov (United States)

    Arageorgis, Aristidis

    2013-08-01

    This paper explores the issues of holism and nonseparability in relativistic quantum field theory (QFT) by focusing on an analog of the typical model featuring in many discussions of holism and nonseparability in nonrelativistic quantum mechanics. It is argued that the quantum field theoretic model does exhibit holism in a metaphysical sense and that there are plausible grounds to view QFT holistic in an epistemological sense. However, the complexities arising from the fact that quantum fields have infinite degrees of freedom prohibit the exploitation of the elaborated analogy toward demonstrating that the QFT model exhibits the kind of state nonseparability familiar from ordinary quantum mechanics. Still, it is argued that the QFT model does satisfy a rather weak epistemological criterion for state nonseparability.

  9. Synaptic dynamics in analog VLSI.

    Science.gov (United States)

    Bartolozzi, Chiara; Indiveri, Giacomo

    2007-10-01

    Synapses are crucial elements for computation and information transfer in both real and artificial neural systems. Recent experimental findings and theoretical models of pulse-based neural networks suggest that synaptic dynamics can play a crucial role for learning neural codes and encoding spatiotemporal spike patterns. Within the context of hardware implementations of pulse-based neural networks, several analog VLSI circuits modeling synaptic functionality have been proposed. We present an overview of previously proposed circuits and describe a novel analog VLSI synaptic circuit suitable for integration in large VLSI spike-based neural systems. The circuit proposed is based on a computational model that fits the real postsynaptic currents with exponentials. We present experimental data showing how the circuit exhibits realistic dynamics and show how it can be connected to additional modules for implementing a wide range of synaptic properties.

  10. Mechanical Analogies of Fractional Elements

    Institute of Scientific and Technical Information of China (English)

    HU Kai-Xin; ZHU Ke-Qin

    2009-01-01

    A Fractional element model describes a special kind of viscoelastic material.Its stress is proportional to the fractional-order derivative of strain. Physically the mechanical analogies of fractional elements can be represented by spring-dashpot fractal networks. We introduce a constitutive operator in the constitutive equations of viscoelastic materials.To derive constitutive operators for spring-dashpot fractal networks, we use Heaviside operational calculus, which provides explicit answers not otherwise obtainable simply.Then the series-parallel formulas for the constitutive operator are derived. Using these formulas, a constitutive equation of fractional element with 1/2-order derivative is obtained.Finally we find the way to derive the constitutive equations with other fractional-order derivatives and their mechanical analogies.

  11. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel

    2017-01-01

    This textbook is appropriate for use in graduate-level curricula in analog-to-digital conversion, as well as for practicing engineers in need of a state-of-the-art reference on data converters. It discusses various analog-to-digital conversion principles, including sampling, quantization, reference generation, nyquist architectures and sigma-delta modulation. This book presents an overview of the state of the art in this field and focuses on issues of optimizing accuracy and speed, while reducing the power level. This new, third edition emphasizes novel calibration concepts, the specific requirements of new systems, the consequences of 22-nm technology and the need for a more statistical approach to accuracy. Pedagogical enhancements to this edition include additional, new exercises, solved examples to introduce all key, new concepts and warnings, remarks and hints, from a practitioner’s perspective, wherever appropriate. Considerable background information and practical tips, from designing a PCB, to lay-o...

  12. Folding model study of the charge-exchange scattering to the isobaric analog state and implication for the nuclear symmetry energy

    Energy Technology Data Exchange (ETDEWEB)

    Khoa, Dao T.; Thang, Dang Ngoc [VINATOM, Institute for Nuclear Science and Technique, Hanoi (Viet Nam); Loc, Bui Minh [VINATOM, Institute for Nuclear Science and Technique, Hanoi (Viet Nam); University of Pedagogy, Ho Chi Minh City (Viet Nam)

    2014-02-15

    The Fermi transition (ΔL = ΔS = 0 and ΔT = 1) between the nuclear isobaric analog states (IAS), induced by the charge-exchange (p, n) or ({sup 3}He, t) reaction, can be considered as ''elastic'' scattering of proton or {sup 3}He by the isovector term of the optical potential (OP) that flips the projectile isospin. The accurately measured (p, n) or ({sup 3}He, t) scattering cross section to the IAS can be used, therefore, to probe the isospin dependence of the proton or {sup 3}He optical potential. Within the folding model, the isovector part of the OP is determined exclusively by the neutron-proton difference in the nuclear densities and the isospin dependence of the effective nucleon-nucleon (NN) interaction. Because the isovector coupling explicitly links the isovector part of the proton or {sup 3}He optical potential to the cross section of the charge-exchange (p, n) or ({sup 3}He, t) scattering to the IAS, the isospin dependence of the effective (in-medium) NN interaction can be well tested in the folding model analysis of these charge-exchange reactions. On the other hand, the same isospin- and density-dependent NN interaction can also be used in a Hartree-Fock calculation of asymmetric nuclear matter, to estimate the nuclear matter energy and its asymmetry part (the nuclear symmetry energy). As a result, the fine-tuning of the isospin dependence of the effective NN interaction against the measured (p, n) or ({sup 3}He, t) cross sections should allow us to make some realistic prediction of the nuclear symmetry energy and its density dependence. (orig.)

  13. License - RMG | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us RMG License Lice...ith the terms and conditions of the license described below. The license specifies the license terms regardi...ng the use of this database and the requirements you must follow in using this database. The lice.... If you use data from this database, please be sure attribute this database as follows: Rice Mitochondrial ...Genome © National Institute of Agrobiological Sciences licensed under CC Attribut

  14. Current safety issues of CANDU licensing

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. [University of Ottawa, Ottawa (Canada); Natalizio, A. [ENSAC Associates, Ontario (Canada)

    1994-01-15

    As requested by Korea Institute of Nuclear Safety(KINS), the status of five generic licensing issues has been examined and their potential impact on a new plant that would be constructed in Canada has been evaluated. The results and conclusions of this evaluation are summarized as follows: steam explosion in calandria, hydrogen explosion in containment, use of PSA in reactor licensing, human factors, safety critical software.

  15. Impact of Ohio Administrative License Suspension*

    OpenAIRE

    Voas, Robert B.; Tippetts, A. Scott; Taylor, Eileen P.

    1998-01-01

    This report covers an analysis of the driving records of Ohio’s 45,788 drivers who were convicted of driving under the influence (DUI) between July 1, 1990, and August 30, 1995, to determine the specific deterrent impact of the Ohio administrative license suspension (ALS**) law on DUI recidivism. Our data support the conclusion that, under the ALS law, license suspensions were earlier and more certain. Consequently, the number of drunk-driving convictions, moving offenses, and crashes of firs...

  16. Low Power CMOS Analog Multiplier

    Directory of Open Access Journals (Sweden)

    Shipra Sachan

    2015-12-01

    Full Text Available In this paper Low power low voltage CMOS analog multiplier circuit is proposed. It is based on flipped voltage follower. It consists of four voltage adders and a multiplier core. The circuit is analyzed and designed in 0.18um CMOS process model and simulation results have shown that, under single 0.9V supply voltage, and it consumes only 31.8µW quiescent power and 110MHZ bandwidth.

  17. Revised Subjects of the Current Korean Oriental Pharmacists' Licensing Examination

    Directory of Open Access Journals (Sweden)

    Jong-Pil Lim

    2007-12-01

    Full Text Available This study is designed to draw out new integrated subjects of the Korean Oriental Pharmacists??Licensing Examination (KOPLE. In 2004, for the revision of subjects, we have analyzed the curriculums of the Oriental Pharmacy department, the oriental pharmacist?占퐏 (OP?占퐏 job description book, and the elementary items of KOPLE. We also examined the system of the Chinese Herb Pharmacists??Examination and other health personnel licensing examinations and studied the data of items and compared them with KOPLE. We heard the public opinion on the present KOPLE. We developed a subfield of 18 subjects, a middle category of 188 items, and a small category of 1,026 items. We proposed a new KOPLE that consists of three subjects: basic oriental pharmacy, applied oriental pharmacy, and laws and regulations.

  18. Benchmark for license plate character segmentation

    Science.gov (United States)

    Gonçalves, Gabriel Resende; da Silva, Sirlene Pio Gomes; Menotti, David; Shwartz, William Robson

    2016-09-01

    Automatic license plate recognition (ALPR) has been the focus of many researches in the past years. In general, ALPR is divided into the following problems: detection of on-track vehicles, license plate detection, segmentation of license plate characters, and optical character recognition (OCR). Even though commercial solutions are available for controlled acquisition conditions, e.g., the entrance of a parking lot, ALPR is still an open problem when dealing with data acquired from uncontrolled environments, such as roads and highways when relying only on imaging sensors. Due to the multiple orientations and scales of the license plates captured by the camera, a very challenging task of the ALPR is the license plate character segmentation (LPCS) step, because its effectiveness is required to be (near) optimal to achieve a high recognition rate by the OCR. To tackle the LPCS problem, this work proposes a benchmark composed of a dataset designed to focus specifically on the character segmentation step of the ALPR within an evaluation protocol. Furthermore, we propose the Jaccard-centroid coefficient, an evaluation measure more suitable than the Jaccard coefficient regarding the location of the bounding box within the ground-truth annotation. The dataset is composed of 2000 Brazilian license plates consisting of 14000 alphanumeric symbols and their corresponding bounding box annotations. We also present a straightforward approach to perform LPCS efficiently. Finally, we provide an experimental evaluation for the dataset based on five LPCS approaches and demonstrate the importance of character segmentation for achieving an accurate OCR.

  19. A global analog of Cheshire charge

    CERN Document Server

    McGraw, P

    1994-01-01

    It is shown that a model with a spontaneously broken global symmetry can support defects analogous to Alice strings, and a process analogous to Cheshire charge exchange can take place. A possible realization in superfluid He-3 is pointed out.

  20. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Mata, Jonatas F.C. da; Vasconcelos, Vanderley de; Mesquita, Amir Z., E-mail: jonatasfmata@yahoo.com.br, E-mail: vasconv@cdtn.br, E-mail: amir@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  1. Digitoxin and its analogs as novel cancer therapeutics

    Directory of Open Access Journals (Sweden)

    Elbaz Hosam A

    2012-04-01

    Full Text Available Abstract A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs.

  2. Interaction of algorithm and implementation for analog VLSI stereo vision

    Science.gov (United States)

    Hakkarainen, J. M.; Little, James J.; Lee, Hae-Seung; Wyatt, John L., Jr.

    1991-07-01

    Design of a high-speed stereo vision system in analog VLSI technology is reported. The goal is to determine how the advantages of analog VLSI--small area, high speed, and low power-- can be exploited, and how the effects of its principal disadvantages--limited accuracy, inflexibility, and lack of storage capacity--can be minimized. Three stereo algorithms are considered, and a simulation study is presented to examine details of the interaction between algorithm and analog VLSI implementation. The Marr-Poggio-Drumheller algorithm is shown to be best suited for analog VLSI implementation. A CCD/CMOS stereo system implementation is proposed, capable of operation at 6000 image frame pairs per second for 48 X 48 images, and faster than frame rate operation on 256 X 256 binocular image pairs.

  3. Energy Harvesting Using an Analog Circuit under Multimodal Vibration

    Directory of Open Access Journals (Sweden)

    Shigeru Shimose

    2013-01-01

    Full Text Available The efficiency of harvesting energy from a vibrating structure using a piezoelectric transducer and a simple analog circuit is investigated experimentally. This analog circuit was originally invented for a synchronized switch damping on inductor (SSDI technique, which enhances the damping of mechanical vibration. In this study, the circuit is used to implement a synchronized switch harvesting on inductor (SSHI technique. A multiple degree of freedom (MDOF structure is excited by single sinusoidal forces at its resonant frequencies and by random forces. The piezoelectric transducer converts this mechanical energy into electrical energy which is harvested using a standard rectifier bridge circuit with and without our analog circuit. Experimental results show that our analog circuit makes it possible to harvest twice as much energy under both single sinusoidal and random vibration excitations.

  4. Investigating visual analogies for visual insight problems

    OpenAIRE

    Corina Sas; Eric Luchian; Linden Ball

    2010-01-01

    Much research has focused on the impact of analogies in insight problem solving, but less work has investigated how the visual analogies for insight are actually constructed. Thus, it appears that in the search for their facilitative impact on the incubation effect, the understanding of what makes good visual analogies has somehow been lost. This paper presents preliminary work of constructing a set of 6 visual analogies and evaluating their impact on solving the visual problem of eight coins...

  5. Quality Assessment of Compressed Video for Automatic License Plate Recognition

    DEFF Research Database (Denmark)

    Ukhanova, Ann; Støttrup-Andersen, Jesper; Forchhammer, Søren;

    2014-01-01

    Definition of video quality requirements for video surveillance poses new questions in the area of quality assessment. This paper presents a quality assessment experiment for an automatic license plate recognition scenario. We explore the influence of the compression by H.264/AVC and H.265/HEVC...... recognition in our study has a behavior similar to human recognition, allowing the use of the same mathematical models. We furthermore propose an application of one of the models for video surveillance systems...

  6. Analogical Reasoning: A Review of the Literature.

    Science.gov (United States)

    Dawis, Rene V.; Siojo, Luis T.

    The mathematical and philosophical origins of "analogy" are described and their influence on the thinking of intelligence theorists is traced. Theories of intelligence and cognition bearing on analogical reasoning are examined, specifically those of Spearman, Thorndike, Guilford and Piaget. The analogy test item is shown to be a paradigm…

  7. Reasoning by Analogy in Constructing Mathematical Ideas.

    Science.gov (United States)

    English, Lyn D.

    A powerful way of understanding something new is by analogy with something already known. An analogy is defined as a mapping from one structure, which is already known (the base or source), to another structure that is to be inferred or discovered (the target). The research community has given considerable attention to analogical reasoning in the…

  8. Reasoning by analogy requires the left frontal pole: lesion-deficit mapping and clinical implications.

    Science.gov (United States)

    Urbanski, Marika; Bréchemier, Marie-Laure; Garcin, Béatrice; Bendetowicz, David; Thiebaut de Schotten, Michel; Foulon, Chris; Rosso, Charlotte; Clarençon, Frédéric; Dupont, Sophie; Pradat-Diehl, Pascale; Labeyrie, Marc-Antoine; Levy, Richard; Volle, Emmanuelle

    2016-06-01

    SEE BURGESS DOI101093/BRAIN/AWW092 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE  : Analogical reasoning is at the core of the generalization and abstraction processes that enable concept formation and creativity. The impact of neurological diseases on analogical reasoning is poorly known, despite its importance in everyday life and in society. Neuroimaging studies of healthy subjects and the few studies that have been performed on patients have highlighted the importance of the prefrontal cortex in analogical reasoning. However, the critical cerebral bases for analogical reasoning deficits remain elusive. In the current study, we examined analogical reasoning abilities in 27 patients with focal damage in the frontal lobes and performed voxel-based lesion-behaviour mapping and tractography analyses to investigate the structures critical for analogical reasoning. The findings revealed that damage to the left rostrolateral prefrontal region (or some of its long-range connections) specifically impaired the ability to reason by analogies. A short version of the analogy task predicted the existence of a left rostrolateral prefrontal lesion with good accuracy. Experimental manipulations of the analogy tasks suggested that this region plays a role in relational matching or integration. The current lesion approach demonstrated that the left rostrolateral prefrontal region is a critical node in the analogy network. Our results also suggested that analogy tasks should be translated to clinical practice to refine the neuropsychological assessment of patients with frontal lobe lesions.

  9. The National Site Licensing of Electronic Resources: An Institutional Perspective

    Directory of Open Access Journals (Sweden)

    Xiaohua Zhu

    2011-06-01

    Full Text Available While academic libraries in most countries are struggling to negotiate with publishers and vendors individually or collaboratively via consortia, a few countries have experimented with a different model, national site licensing (NSL. Because NSL often involves government and large-scale collaboration, it has the potential to solve many problems in the complex licensing world. However, not many nations have adopted it. This study uses historical research approach and the comparative case study research method to explore the seemingly low level of adoption. The cases include the Canadian National Site Licensing Project (CNSLP, the United Kingdom’s National Electronic Site Licensing Initiative (NESLI, and the United States, which has not adopted NSL. The theoretical framework guiding the research design and data collection is W. Richard Scott’s institutional theory, which utilizes three supporting pillars—regulative, normative, and cultural-cognitive—to analyze institutional processes. In this study, the regulative pillar and the normative pillar of NSL adoption— an institutional construction and change—are examined. Data were collected from monographs, research articles, government documents, and relevant websites. Based on the analysis of these cases, a preliminary model is proposed for the adoption of NSL. The factors that support a country’s adoption of NSL include the need for new institutions, a centralized educational policy-making system and funding system, supportive political trends, and the tradition of cooperation. The factors that may prevent a country from adopting NSL include decentralized educational policy and funding, diversity and the large number of institutions, the concern for the “Big Deal,” and the concern for monopoly.

  10. The need for national medical licensing examination in Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Alzahrani Khalid

    2008-11-01

    Full Text Available Abstract Background Medical education in Saudi Arabia is facing multiple challenges, including the rapid increase in the number of medical schools over a short period of time, the influx of foreign medical graduates to work in Saudi Arabia, the award of scholarships to hundreds of students to study medicine in various countries, and the absence of published national guidelines for minimal acceptable competencies of a medical graduate. Discussion We are arguing for the need for a Saudi national medical licensing examination that consists of two parts: Part I (Written which tests the basic science and clinical knowledge and Part II (Objective Structured Clinical Examination which tests the clinical skills and attitudes. We propose this examination to be mandated as a licensure requirement for practicing medicine in Saudi Arabia. Conclusion The driving and hindering forces as well as the strengths and weaknesses of implementing the licensing examination are discussed in details in this debate.

  11. Technology Licensing Strategy for Network Product in a Service Industry

    Directory of Open Access Journals (Sweden)

    Xianpei Hong

    2015-01-01

    Full Text Available Technology licensing has gained significant attention in literature and practice as a rapid and effective way to improve firm’s capability of technology innovation. In this paper, we investigate a duopolistic service provider competition market, where service providers develop and sell a kind of network product. In this setting, we analyze the innovating service provider’s four licensing strategies: no licensing, fixed fee licensing, royalty licensing, and two-part tariff licensing. The literature suggests that when the network products can be completely substituted, two-part tariff licensing is the optimal strategy of the innovating service provider. We find that when the network products cannot be completely substituted, two-part tariff licensing is not always optimal. The degree of the product differentiation, the intensity of the network effects, and the R&D cost of the potential licensee play a key role in determining the innovating service provider’s optimal licensing strategies.

  12. Structure- and isoform-specific glucuronidation of six curcumin analogs.

    Science.gov (United States)

    Lu, Danyi; Liu, Hui; Ye, Wencai; Wang, Ying; Wu, Baojian

    2017-04-01

    1. In the present study, we aimed to characterize the glucuronidation of six curcumin analogs (i.e. RAO-3, RAO-8, RAO-9, RAO-18, RAO-19, and RAO-23) derived from galangal using human liver microsomes (HLM) and twelve expressed UGT enzymes. 2. Formation of glucuronide was confirmed using high-resolution mass spectrometry. Single glucuronide metabolite was generated from each of six curcumin analogs. The fragmentation patterns were analyzed and were found to differ significantly between alcoholic and phenolic glucuronides. 3. All six curcumin analogs except one (RAO-23) underwent significant glucuronidation in HLM and expressed UGT enzymes. In general, the methoxy group (close to the phenolic hydroxyl group) enhanced the glucuronidation liability of the curcumin analogs. 4. UGT1A9 and UGT2B7 were primarily responsible for the glucuronidation of two alcoholic analogs (RAO-3 and RAO-18). By contrast, UGT1A9 and four UGT2Bs (UGT2B4, 2B7, 2B15 and 2B17) played important roles in conjugating three phenolic analogs (RAO-8, RAO-9, and RAO-19). Interestingly, the conjugated double bonds system (in the aliphatic chain) was crucial to the substrate selectivity of gastrointestinal UGTs (i.e. UGT1A7, 1A8 and 1A10). 5. In conclusion, glucuronidation of six curcumin analogs from galangal were structure- and isoform-specific. The knowledge should be useful in identifying a curcumin analog with improved metabolic property.

  13. Analog circuit design art, science, and personalities

    CERN Document Server

    Williams, Jim

    1991-01-01

    Analog Circuit Design: Art, Science, and Personalities discusses the many approaches and styles in the practice of analog circuit design. The book is written in an informal yet informative manner, making it easily understandable to those new in the field. The selection covers the definition, history, current practice, and future direction of analog design; the practice proper; and the styles in analog circuit design. The book also includes the problems usually encountered in analog circuit design; approach to feedback loop design; and other different techniques and applications. The text is

  14. Analog and mixed-signal electronics

    CERN Document Server

    Stephan, Karl

    2015-01-01

    A practical guide to analog and mixed-signal electronics, with an emphasis on design problems and applications This book provides an in-depth coverage of essential analog and mixed-signal topics such as power amplifiers, active filters, noise and dynamic range, analog-to-digital and digital-to-analog conversion techniques, phase-locked loops, and switching power supplies. Readers will learn the basics of linear systems, types of nonlinearities and their effects, op-amp circuits, the high-gain analog filter-amplifier, and signal generation. The author uses system design examples to motivate

  15. Cartographic distortions make dielectric spacetime analog models imperfect mimickers

    Science.gov (United States)

    Fathi, Mohsen; Thompson, Robert T.

    2016-06-01

    It is commonly assumed that if the optical metric of a dielectric medium is identical to the metric of a vacuum space-time then light propagation through the dielectric mimics light propagation in the vacuum. However, just as the curved surface of the Earth cannot be mapped into a flat plane without distortion of some surface features, so too is it impossible to project the behavior of light from the vacuum into a dielectric analog residing in Minkowski space-time without introducing distortions. We study the covariance properties of dielectric analog space-times and the kinematics of a congruence of light in the analog, and show how certain features can be faithfully emulated in the analog depending on the choice of projection, but that not all features can be simultaneously emulated without distortion. These findings indicate conceptual weaknesses in the idea of using analog space-times as a basis for transformation optics, and we show that a certain formulation of transformation optics closely related to analog space-times resolves these issues.

  16. Early Warning of Heat/Cold Waves as a Smart City Subsystem: A Retrospective Case Study of Non-anticipative Analog methodology

    Directory of Open Access Journals (Sweden)

    Dmytro Zubov

    2015-12-01

    Full Text Available In this paper, the self-organizing inductive methodology is applied for the non-anticipative analog forecasting of the heat/cold waves in the natural environment subsystem of the smart city. The prediction algorithm is described by two paradigms. First one (short range uses quantum computing formalism. D-Wave adiabatic quantum computing Ising model is employed and evaluated for the forecasting of positive extremes of daily mean air temperature. Forecast models are designed with two to five qubits, which represent 2-, 3-, 4-, and 5-day historical data, respectively. Ising model’s real-valued weights and dimensionless coefficients are calculated using daily mean air temperatures from 119 places around the world as well as sea level (Aburatsu, Japan. The proposed forecast quantum computing algorithm is simulated based on traditional computer architecture and combinatorial optimization of Ising model parameters for the Ronald Reagan Washington National Airport dataset with 1-day lead-time on learning sample 1975-2010 yr. Analysis of the forecast accuracy (ratio of successful predictions to total number of predictions on the validation sample 2011-2014 yr shows that Ising model with three qubits has 100% accuracy, which is significant as compared to other methods. However, number of identified heat waves is small (only one out of nineteen in this case. Second paradigm (long range uses classical computation in the Microsoft Azure public cloud. Here, the forecast method identifies the dependencies between the current values of two meteorological variables and the future state of another variable. The method is applied to the prediction of heat/cold waves at Ronald Reagan Washington National Airport. The data include the above-stated datasets plus monthly mean Darwin and Tahiti sea level pressures, SOI, equatorial SOI, sea surface temperature, and multivariate ENSO index (131 datasets in total. Every dataset is split into two samples, for learning and

  17. Practical analog electronics for technicians

    CERN Document Server

    Kimber, W A

    2013-01-01

    'Practical Analog Electronics for Technicians' not only provides an accessible introduction to electronics, but also supplies all the problems and practical activities needed to gain hands-on knowledge and experience. This emphasis on practice is surprisingly unusual in electronics texts, and has already gained Will Kimber popularity through the companion volume, 'Practical Digital Electronics for Technicians'. Written to cover the Advanced GNVQ optional unit in electronics, this book is also ideal for BTEC National, A-level electronics and City & Guilds courses. Together with 'Practical Digit

  18. Use of Curricular and Extracurricular Assessments to Predict Performance on the United States Medical Licensing Examination (USMLE) Step 1: A Multi-Year Study

    Science.gov (United States)

    Gandy, Robyn A.; Herial, Nabeel A.; Khuder, Sadik A.; Metting, Patricia J.

    2008-01-01

    This paper studies student performance predictions based on the United States Medical Licensure Exam (USMLE) Step 1. Subjects were second-year medical students from academic years of 2002 through 2006 (n = 711). Three measures of basic science knowledge (two curricular and one extracurricular) were evaluated as predictors of USMLE Step 1 scores.…

  19. The Demand for Associate Degree Nursing Education in Central Indiana: A Study of the Personal, Academic, and Professional Characteristics of Licensed Practical Nurses.

    Science.gov (United States)

    Peters, Faye L.; Khoury, Robert M.

    Since 1977, Indiana University--Purdue University at Indianapolis, Columbus Campus has been exploring the potential for offering a nursing program under the aegis of the the Indiana University School of Nursing. In May 1984, a study was conducted to determine community support for the development of a major nursing component for a Licensed…

  20. How do Analogizing and Mental Simulation Influence Team Dynamics in Innovative Product Design?

    DEFF Research Database (Denmark)

    Casakin, Hernan; Ball, Linden J.; Christensen, Bo T.;

    2015-01-01

    The aim of this study was to gain further insight into how analogical reasoning and mental simulation, two cognitive strategies, influence team dynamics in innovative product design. A particular emphasis was placed on exploring the association between these two strategies and team cohesion...... and team collaboration. Analogies were coded for “analogical distance” (i.e., within domain or between domain) and “analogical purpose” (i.e., problem identification, function finding, solution generation, and explanation). The results indicated that the presence of either analogizing or mental simulation...... was related to team cohesion and team collaboration, with mental simulation having an especially marked association with team collaboration. Within-domain analogizing was found to enhance team collaboration, but it did not influence team cohesion. Furthermore, all types of analogical purpose showed a similar...

  1. Transfer Between Analogies: How Solving One Analogy Problem Helps to Solve Another

    OpenAIRE

    Keane, Mark T.

    1995-01-01

    This paper deals with transfer between analogies; with what people acquire from one analogy problem-solving episode that can be re-applied to a subsequent analogy, problem-solving episode. This issue must be resolved if we are to understand the nature of expertise and the appropriate use of analogy in education. There are two main explanations of what subjects acquire from an analogy problem-solving episode. The schema-induction hypothesis maintains that subjects acquire an abs...

  2. Study on Licensing Strategies of New Product Innovation in a Differentiated Stackelberg Duopoly%异质 Stackelberg 寡头竞争下创新产品技术许可策略研究

    Institute of Scientific and Technical Information of China (English)

    王静; 包振华

    2015-01-01

    Based on a differentiated Stackelberg duopoly,this paper established a licensing game model in which an in-cumbent innovator competing with a potential rival can develop the technology for the new product,or accept the licensing to enter the market.Depending on the two scenarios for the development cost,the optimal two-part tariff licensing strategies for the innovator were investigated.It concludes that the technology is always licensed and the optimal licensing contract depends on the development cost incurred by the rival,the market parameter and the substitution coefficient.%基于异质产品 Stackelberg 寡头竞争模型,建立了拥有新产品创新技术在位厂商与潜在竞争对手间的技术许可博弈模型。模型中假设潜在竞争对手可以接受许可,也可通过自我研发创新技术进入市场参与竞争。根据潜在竞争对手研发成本的高低,研究了创新厂商的最优两部制收费策略。研究结果表明:潜在竞争者总会接受创新技术许可,最优许可策略依赖于研发成本、市场参数以及产品的替代系数。

  3. Small modular reactors: current status, economic aspects and licensing

    Energy Technology Data Exchange (ETDEWEB)

    Zimbron E, E. [Instituto Tecnologico de Estudios Superiores de Monterrey, Campus Santa Fe, Av. Carlos Lazo No. 100, Santa Fe, 01389 Mexico D. F. (Mexico); Puente E, F., E-mail: erick.zimbron@gmail.com [ININ, Direccion de Investigacion Cientifica, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    Interest for nuclear energy had resurgence since the beginning of the new century. This was a consequence of the new world conditions and needs: increasing energy demands (mainly from developing countries), awareness of the importance of energetic security and the necessity of limiting carbon emissions. In this nuclear boom, Small Modular Reactors (SMRs) develop and start to consolidate as a viable option for the present energy market. Their modular characteristics, lower initial capital cost, passive safety features and their niche applications, situate them as a technology with various advantages. The following study will present and analysis that will help to comprehend the SMRs present status. Information will show planned reactors, reactors in construction and in operation, advantages and challenges of their implementation, relevant economic aspects and important licensing factors that need to be highlighted. The analysis showed that the SMR technology is still in an initial stage that could reach and important development point in the next ten years. In this period, many of the reactors that are in design stage or that are through their licensing process might be constructed and could be getting ready for a commercial status. On the other hand, it has been observed that there are two main economic factors that need to be considered for any SMRs implementation project. First, the costs (initial, operation, maintenance, fuel and decommissioning) and second their possible niche market applications. Additionally, it has been noted that the licensing process is one of the greatest challenges for SMR general development. Licensing is mainly related to topic such as Emergency Planning Zone, first-of-a-kind engineering, passive safety features, proliferation resistance, multiple module designs and staffing. Previous information will serve as a base for carrying out a feasibility assessment analysis for SMR in Mexico. This part will be the last section of the project

  4. SSERVI Analog Regolith Simulant Testbed Facility

    Science.gov (United States)

    Minafra, Joseph; Schmidt, Gregory; Bailey, Brad; Gibbs, Kristina

    2016-10-01

    The Solar System Exploration Research Virtual Institute (SSERVI) at NASA's Ames Research Center in California's Silicon Valley was founded in 2013 to act as a virtual institute that provides interdisciplinary research centered on the goals of its supporting directorates: NASA Science Mission Directorate (SMD) and the Human Exploration & Operations Mission Directorate (HEOMD).Primary research goals of the Institute revolve around the integration of science and exploration to gain knowledge required for the future of human space exploration beyond low Earth orbit. SSERVI intends to leverage existing JSC1A regolith simulant resources into the creation of a regolith simulant testbed facility. The purpose of this testbed concept is to provide the planetary exploration community with a readily available capability to test hardware and conduct research in a large simulant environment.SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers.SSERVI provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment.The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area, including dust mitigation and safety oversight.Facility hardware and environment testing scenarios could include, Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, Surface features (i.e. grades and rocks)Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and

  5. License - PLACE | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us PLACE License Lice... with the terms and conditions of the license described below. The license specifies the license terms regar...ding the use of this database and the requirements you must follow in using this database. The lice... Institute of Agrobiological Sciences licensed under CC Attribution-Share Alike 2... to this database, you are licensed to: freely access part or whole of this database, and acquire data; free

  6. License - KOME | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us KOME License Lice...with the terms and conditions of the license described below. The license specifies the license terms regard...ing the use of this database and the requirements you must follow in using this database. The lice...uchi (National Institute of Agrobiological Sciences) licensed under CC Attributio...e . With regard to this database, you are licensed to: freely access part or whole of this database, and acq

  7. License - RPSD | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us RPSD License Lice...with the terms and conditions of the license described below. The license specifies the license terms regard...ing the use of this database and the requirements you must follow in using this database. The lice...on of Protein © National Institute of Agrobiological Sciences licensed under CC A...found here . With regard to this database, you are licensed to: freely access part or whole of this database

  8. License - DGBY | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available [ Credits ] BLAST Search Image Search Home About Archive Update History Contact us DGBY License Lice...with the terms and conditions of the license described below. The license specifies the license terms regard...ing the use of this database and the requirements you must follow in using this database. The lice...(National Food Research Institute) licensed under CC Attribution-Share Alike 2.1 ... this database, you are licensed to: freely access part or whole of this database, and acquire data; freely

  9. A BWR licensing experience in the USA

    Energy Technology Data Exchange (ETDEWEB)

    Powers, J.; Ogura, C. [Toshiba America Nuclear Energy, Charlotte, North Carolina (United States); Arai, K. [Toshiba Corporation, Yokohama, Kanagawa (Japan); Thomas, S.; Mookhoek, B., E-mail: jim.powers@toshiba.com [Nuclear Innovation North America, Lake Jackson, Texas (United States)

    2015-09-15

    The US-Advanced Boiling Water Reactor (A BWR), certified by the United States Nuclear Regulatory Commission (US NRC), is a third generation, evolutionary boiling water reactor design which is the reference for the South Texas Project Units 3 and 4 (STP3-4) Combined License Application (Cola). Nuclear Innovation North America (Nina) is the License Applicant for this new build project, and Toshiba is the selected primary technology contractor. The STP3-4 project has finished the US NRC technical review of the Cola through the final meeting of the Advisory Committee on Reactor Safeguards (ACRS), and the Final Safety Evaluation Report (FSER) is scheduled to be issued by the US NRC in the middle of 2015. The next steps are to support the Mandatory Hearing process, and voting by the NRC commissioners on the motion to grant the Combined License, which is scheduled beginning of 2016 according to US NRC schedule as of March 30, 2015. This paper summarizes the history and progress of the US-A BWR licensing, including the experiences of the Licensee, Nina, and Toshiba as the Epc team worked through the Code of Federal Regulations Title 10 (10-Cfr) Part 52 process, and provides some perspectives on how the related licensing material would also be of value within a 10-Cfr Part 50, two-step process to minimize schedule and financial risks which could arise from ongoing technical developments and regulatory reviews. (Author)

  10. Patents and licensing in pharmaceutical industry

    Directory of Open Access Journals (Sweden)

    Katerina Ancevska Netkovska

    2005-05-01

    Full Text Available Intellectual property rights (IPR have been defined as ideas, inventions, and creative expressions based on which there is a public willingness to bestow the status of property. IPR provide certain exclusive rights to the inventors or creators of that property, in order to enable them to reap commercial benefits from their creative efforts or reputation. There are several types of intellectual property protection like patent, copyright, trademark, etc. Patent is recognition for an invention, which satisfies the criteria of global novelty, non-obviousness, and industrial application. IPR is prerequisite for better identification, planning, commercialization, rendering, and thereby protection of invention or creativity. Each industry should evolve its own IPR policies, management style, strategies, and so on depending on its area of specialty. Pharmaceutical industry currently has an evolving IPR strategy requiring a better focus and approach in the coming era. The protection of inventions with patents in the pharmaceutical industry have a specific role in the development of society and represent one of the drivers of economic development. The license agreements are considered as one of the most common types of transfer of industrial property rights. The right holders often transfer their rights to patents by concluding licensing agreement. While the patent license may give the license a right to use the technology many license agreements have provisions for the transfer of know-how in addition to the patent.

  11. Analog modelling of obduction processes

    Science.gov (United States)

    Agard, P.; Zuo, X.; Funiciello, F.; Bellahsen, N.; Faccenna, C.; Savva, D.

    2012-04-01

    Obduction corresponds to one of plate tectonics oddities, whereby dense, oceanic rocks (ophiolites) are presumably 'thrust' on top of light, continental ones, as for the short-lived, almost synchronous Peri-Arabic obduction (which took place along thousands of km from Turkey to Oman in c. 5-10 Ma). Analog modelling experiments were performed to study the mechanisms of obduction initiation and test various triggering hypotheses (i.e., plate acceleration, slab hitting the 660 km discontinuity, ridge subduction; Agard et al., 2007). The experimental setup comprises (1) an upper mantle, modelled as a low-viscosity transparent Newtonian glucose syrup filling a rigid Plexiglas tank and (2) high-viscosity silicone plates (Rhodrosil Gomme with PDMS iron fillers to reproduce densities of continental or oceanic plates), located at the centre of the tank above the syrup to simulate the subducting and the overriding plates - and avoid friction on the sides of the tank. Convergence is simulated by pushing on a piston at one end of the model with velocities comparable to those of plate tectonics (i.e., in the range 1-10 cm/yr). The reference set-up includes, from one end to the other (~60 cm): (i) the piston, (ii) a continental margin containing a transition zone to the adjacent oceanic plate, (iii) a weakness zone with variable resistance and dip (W), (iv) an oceanic plate - with or without a spreading ridge, (v) a subduction zone (S) dipping away from the piston and (vi) an upper, active continental margin, below which the oceanic plate is being subducted at the start of the experiment (as is known to have been the case in Oman). Several configurations were tested and over thirty different parametric tests were performed. Special emphasis was placed on comparing different types of weakness zone (W) and the extent of mechanical coupling across them, particularly when plates were accelerated. Displacements, together with along-strike and across-strike internal deformation in all

  12. Analog-to-digital conversion

    CERN Document Server

    Pelgrom, Marcel J. M

    2013-01-01

    This textbook is appropriate for use in graduate-level curricula in analog to digital conversion, as well as for practicing engineers in need of a state-of-the-art reference on data converters.  It discusses various analog-to-digital conversion principles, including sampling, quantization, reference generation, nyquist architectures and sigma-delta modulation.  This book presents an overview of the state-of-the-art in this field and focuses on issues of optimizing accuracy and speed, while reducing the power level. This new, second edition emphasizes novel calibration concepts, the specific requirements of new systems, the consequences of 45-nm technology and the need for a more statistical approach to accuracy.  Pedagogical enhancements to this edition include more than twice the exercises available in the first edition, solved examples to introduce all key, new concepts and warnings, remarks and hints, from a practitioner’s perspective, wherever appropriate.  Considerable background information and pr...

  13. From the Chemistry Lab to Licensing

    Science.gov (United States)

    Savino, Joseph M.; Street, Kenneth W.; Philipp, Warren H.

    1998-01-01

    This is a story of technology maturation and transfer, and licensing. It traces the history of the recently patented ion- exchange material (IEM) from the accidental discovery that this polymer, a battery separator of marginal performance, picked up copper from distilled water passing through corroded copper tubing in the laboratory, to a point where five organizations and one individual have applied for licenses to manufacture and market it or to use it in a wide variety of applications. This story discusses in detail the problems of converting an immature technology into a mature and eventually commercialized technology, without dedicated resources. Readers will develop an appreciation for how the obstacles to maturation and licensing of the technology were faced and overcome. The lessons learned will be discussed, with the hope of enhancing the technology transfer process.

  14. Partner Selection in Technological Licensing Agreements

    DEFF Research Database (Denmark)

    Laursen, Keld; Trombini, Giulia

    as attractors, and market competition and potential involuntary spillovers act as repellants. Firms seek potential licensing partners by trying to maximize technological synergies while attempting to minimize the competitive downsides. We hypothesize that when licensees engage in matches involving a partner...... that is technologically unrelated, ex ante familiarity with the licensors’ technology is required. We contend also that there is interdependence between technological learning and market competition: if partners are in the same product markets, the likelihood of technology license contractual partnerships decreases...... with partners’ technological relatedness. We use data on the formation of license partnerships in the global biopharmaceutical industry over the period 1994-2004 and find that, on the whole, there is empirical support for our theoretical predictions....

  15. Functional and topological studies with Trp-containing analogs of the peptide StII(1-30) derived from the N-terminus of the pore forming toxin sticholysin II: contribution to understand its orientation in membrane.

    Science.gov (United States)

    Ros, Uris; Souto, Ana Lucia C F; de Oliveira, Felipe J; Crusca, Edson; Pazos, Fabiola; Cilli, Eduardo M; Lanio, Maria E; Schreier, Shirley; Alvarez, Carlos

    2013-07-01

    Sticholysin II (St II) is the most potent cytolysin produced by the sea anemone Stichodactyla helianthus, exerting hemolytic activity via pore formation in membranes. The toxin's N-terminus contains an amphipathic α-helix that is very likely involved in pore formation. We have previously demonstrated that the synthetic peptide StII(1-30) encompassing the 1-30 segment of St II forms pores of similar radius to that of the protein (around 1 nm), being a good model of toxin functionality. Here we have studied the functional and conformational properties of fluorescent analogs of StII(1-30) in lipid membranes. The analogs were obtained by replacing Leu residues at positions 2, 12, 17, and 24 with the intrinsically fluorescent amino acid Trp (StII(1-30L2W), StII(1-30L12W), StII(1-30L17W), or StII(1-30L24W), respectively). The exchange by Trp did not significantly modify the activity and conformation of the parent peptide. The blue-shift and intensity enhancement of fluorescence in the presence of membrane indicated that Trp at position 2 is more deeply buried in the hydrophobic region of the bilayer. These experiments, as well as assays with water-soluble or spin-labeled lipid-soluble fluorescence quenchers suggest an orientation of StII(1-30) with its N-terminus oriented towards the hydrophobic core of the bilayer while the rest of the peptide is more exposed to the aqueous environment, as hypothesized for sticholysins.

  16. Analogies as Tools for Meaning Making in Elementary Science Education: How Do They Work in Classroom Settings?

    Science.gov (United States)

    Guerra-Ramos, Maria Teresa

    2011-01-01

    In this paper there is a critical overview of the role of analogies as tools for meaning making in science education, their advantages and disadvantages. Two empirical studies on the use of analogies in primary classrooms are discussed and analysed. In the first study, the "string circuit" analogy was used in the teaching of electric circuits with…

  17. PC-based car license plate reader

    Science.gov (United States)

    Hwang, Chung-Mu; Shu, Shyh-Yeong; Chen, Wen-Yu; Chen, Yie-Wern; Wen, Kuang-Pu

    1992-11-01

    A car license plate reader (CLPR) using fuzzy inference and neural network algorithm has been developed in Industrial Technology Research Institute (ITRI) and installed in highway toll stations to identify stolen cars. It takes an average of 0.7 seconds to recognize a car license plate by using a PC with 80486-50 CPU. The recognition rate of the system is about 97%. The techniques of CLPR include vehicle sensing, image grab control, optic pre- processing, lighting, and optic character recognition (OCR). The CLPR can be used in vehicle flow statistics, the checking of stolen vehicles, automatic charging systems in parking lots or garage management, and so on.

  18. Amygdalin analogs for the treatment of psoriasis.

    Science.gov (United States)

    Perez, Juan J

    2013-05-01

    Psoriasis is one of the most prevalent immune-mediated illness worldwide. The disease can still only be managed rather than cured, so treatments are aimed at clearing skin lesions and preventing their recurrence. Several treatments are available depending on the extent of the psoriatic lesion. Among the topical treatments corticostereoids, vitamin D3 analogs and retinoids are commonly used. However, these treatments may have adverse effects in the long term. Conversely, systemic conventional treatments include immunosuppresors such as cyclosporin or methotrexate associated with high toxicity levels. Biologicals are alternative therapeutical agents introduced in the last 10 years. These include fusion proteins or monoclonal antibodies designed to inhibit the action of specific cytokines or to prevent T-lymphocyte activation. However, due to recent knowledge on the etiology of the disease, diverse new small molecules have appeared as promising alternatives for the treatment of psoriasis. Among them, inhibitors of JAK3, inhibitors of PDE 4 and amygdalin analogs. The latter are promising small molecules presently in preclinical studies which are the object of the present report.

  19. Analog IC reliability in nanometer CMOS

    CERN Document Server

    Maricau, Elie

    2013-01-01

    This book focuses on modeling, simulation and analysis of analog circuit aging. First, all important nanometer CMOS physical effects resulting in circuit unreliability are reviewed. Then, transistor aging compact models for circuit simulation are discussed and several methods for efficient circuit reliability simulation are explained and compared. Ultimately, the impact of transistor aging on analog circuits is studied. Aging-resilient and aging-immune circuits are identified and the impact of technology scaling is discussed.   The models and simulation techniques described in the book are intended as an aid for device engineers, circuit designers and the EDA community to understand and to mitigate the impact of aging effects on nanometer CMOS ICs.   ·         Enables readers to understand long-term reliability of an integrated circuit; ·         Reviews CMOS unreliability effects, with focus on those that will emerge in future CMOS nodes; ·         Provides overview of models for...

  20. Metaphor and analogy in everyday problem solving.

    Science.gov (United States)

    Keefer, Lucas A; Landau, Mark J

    2016-11-01

    Early accounts of problem solving focused on the ways people represent information directly related to target problems and possible solutions. Subsequent theory and research point to the role of peripheral influences such as heuristics and bodily states. We discuss how metaphor and analogy similarly influence stages of everyday problem solving: Both processes mentally map features of a target problem onto the structure of a relatively more familiar concept. When individuals apply this structure, they use a well-known concept as a framework for reasoning about real world problems and candidate solutions. Early studies found that analogy use helped people gain insight into novel problems. More recent research on metaphor goes further to show that activating mappings has subtle, sometimes surprising effects on judgment and reasoning in everyday problem solving. These findings highlight situations in which mappings can help or hinder efforts to solve problems. WIREs Cogn Sci 2016, 7:394-405. doi: 10.1002/wcs.1407 For further resources related to this article, please visit the WIREs website.