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Sample records for ampulla of vater

  1. Benign anatomical mistakes: "ampulla of Vater" and "papilla of Vater".

    Science.gov (United States)

    Mirilas, Petros; Colborn, Gene L; Skandalakis, Lee J; Skandalakis, Panajiotis N; Zoras, Odysseas; Skandalakis, John E

    2005-03-01

    The anatomy of the ampullary termination of the bile and pancreatic ducts is complex; appropriate terminology for this area is confusing and inaccurate. We examine the terms "ampulla of Vater" and "papilla of Vater" for anatomical and historical correctness. The term "ampulla" refers to a dilated part of a duct or other channel. Thus, this word is topographically correct to describe the dilatation at the confluence of the bile and main pancreatic ducts; historically, however, there is considerable reason to believe that its first description was by Santorini rather than Vater. The eponymous term "papilla of Vater" is also incorrect historically. The use of eponyms is firmly entrenched in the medical literature, but some are so problematic that they should be discarded. The eponymous terms for both the ampulla and the papilla should be replaced with the terms "hepatopancreatic ampulla" (or "biliaropancreatic ampulla") and "major [or "greater"] duodenal papilla," respectively.

  2. Large cell neuroendocrine carcinoma of the ampulla of Vater.

    LENUS (Irish Health Repository)

    Beggs, Rachel E

    2012-09-01

    Large cell neuroendocrine carcinomas of the ampulla of Vater are rare and confer a very poor prognosis despite aggressive therapy. There are few case reports of large cell neuroendocrine carcinomas of the ampulla of Vater in the literature and to date no studies have been done to establish optimal management. We describe a pooled case series from published reports of neuroendocrine carcinomas of the ampulla of Vater including a case which presented to our institution.

  3. Carcinoma of ampulla of vater : emphasis on the CT technique

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    Jung, Hyun Seouk; Byun, Jae Young; Jung, So Lyung; Kim, Euy Neyng; Lee, Jae Moon; Shinn, Kyung Sub [Catholic Univ. Medical College, Seoul (Korea, Republic of)

    1997-06-01

    To demonstrate a CT technique by which carcinoma of the ampulla of Vater can be more accurately diagnosed, and to describe the radiologic findings of this carcinoma. We retrospectively reviewed CT findings in 26 patients with pathologically proven carcinoma of the ampulla of Vater. One additional cup of diluted oral contrast medium was ingested immediately before the scan. We analysed the difference in detection rate of the mass in the duodenal lumen with and without duodenal luminal opacification of gastrografin. We also evaluated the size and shape of the mass, dilatation of CBD and the pancreatic duct, and 1ymph node metastasis. In addition, we analyzed multimodality imaging findings(ultrasonogram(US):13;hypotonic duodenogram(HTDG):7;ERCP:17) of carcinoma of the ampulla of Vater. Nodular soft tissue masses protruding into the duodenal lumen were identified in 21 of 26 cases. In 95% of cases (21/22) with favorable opacification and distension of the duodenum, masses were clearly identified on CT imaging. However, in four cases with poor opacification and distension of the duodenum, masses could not be observed(P=0.000). The mass on CT scan showed a well-defined margin, round or lobulated contour, and contrast enhancement simiar to that of the pancreas. CBD dilatation was identified in 20 cases and pancreatic duct dilatation in 12. On US, protruding masses in the distal CBD were observed in nine of 13 cases(60%) and on HTDG, in six of seven cases(86%) as well-defined filling defects. Since the accuracy of CT diagnosis of intestinal lesions is directly proportional to the degree of intestinal distension and opacification with oral contrast, we believe that adequate CT technique for distending and opacitying the duodenal lumen are necessary for early diagnosis of carcinoma of the ampulla of Vater.

  4. Prognostic Factors of Ampulla of Vater Carcinoma after Radical Surgery

    Institute of Scientific and Technical Information of China (English)

    Dongbing Zhao; Yongkai Wu; Yi Shan; Chengfeng Wang; Ping Zhao

    2009-01-01

    OBJECTIVE Ampullary carcinoma is a rare disease with better prognosis than other periampullary neoplasms.This study investigated the association between clinicopathologiC factors and prognosis after radical resection of ampulla of Vater carcinoma.METHODS Clinical data from 105 patients who underwent radical pancreaticoduodenectomy from January 1990 to December 2005 were retrospectively analyzed by the Kaplan-Meier method,log-rank test,and the Cox proportional hazard model.RESULTS The in-hospital mortalitv rate was 8.6%,the lymph node metastasis rate was 37.1%,and the five-year survival rate was 42.8%.Pancreatic involvement(P=0.027),tumor diameter(P =0.008),T stage(P=0.003),TNM stage(P<0.001),and number of metastatic lymph nodes(P<0.001)were associated with prognosis when the univariate analysis was used.Multivariate analysis showed that the number of lymph node metastases (P<0.001;OR:1.923;CI:1.367-2.705)and tumot diameter(P=0.03;OR:1.432;CI:1.035-1.981) were the independent prognostic factors.CONCLUSION The number of metastatic lymph nodes and tumor diameter are important pathologic factors predicting prognosis of ampulla of Vater carcinoma after radical resection,and lymph node dissection during the radical surgery effectively improves the survival rate.

  5. Neuroendocrine carcinoma of the ampulla of Vater causing ectopic adrenocorticotropic hormone-dependent Cushing's syndrome

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    KATO, AKIHISA; HAYASHI, KAZUKI; NAITOH, ITARU; SENO, KYOJI; OKADA, YUKIKO; BAN, TESSHIN; KONDO, HIROMU; NISHI, YUJI; UMEMURA, SHUICHIRO; HORI, YASUKI; NATSUME, MAKOTO; JOH, TAKASHI

    2016-01-01

    Ectopic adrenocorticotropic hormone (ACTH) is rarely secreted by neuroendocrine tumors. Although neuroendocrine tumors may occur at any site in the gastrointestinal system, they very rarely occur in the ampulla of Vater and have a poor prognosis. The present study described the first Cushing's syndrome as a result of ectopic ACTH arising from the ampulla of Vater neuroendocrine carcinoma. A 69-year-old female was admitted with clinical features of Cushing's syndrome, confirmed biochemically by hypokalemia, and elevated levels of ACTH and cortisol. In further investigations, a tumor of the ampulla of Vater and liver metastases were detected. Pathological analysis of the biopsy confirmed a neuroendocrine carcinoma, which was immunohistochemically positive for chromogranin A, synaptophysin, cluster of differentiation 56 and ACTH. Therefore, the present study diagnosed a functional and metastatic neuroendocrine carcinoma of the ampulla of Vater with ectopic ACTH production causing Cushing's syndrome. The patient succumbed to mortality 4 months later, despite administration of combined chemotherapy with irinotecan and cisplatin. PMID:27330779

  6. A rare case of ectopic pancreas in the ampulla of Vater presented with obstructive jaundice.

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    Filippou, Dimitrios K; Vezakis, Antonios; Filippou, Georgios; Condilis, Nicolas; Rizos, Spiros; Skandalakis, Panagiotis

    2006-01-01

    A rare case of ectopic pancreas in the ampulla of Vater presented with obstructive jaundice. Ectopic pancreas is a common congenital disorder which is referred to as pancreatic rest. The incidence in autopsy series varies from 1 to 2% (range 0.55 to 13%). Most common site of ectopic pancreatic tissue is the stomach, although it can be found anywhere in the foregut and the proximal midgut. Ectopic pancreatic tissue in the ampulla of Vater is a very rare condition. Searching in the literature, using the terms "ectopic pancreas" and "Ampulla of Vater", we found only 10 records. The authors report on a rare case of a 69 years old female with ectopic pancreas in the ampulla of Vater, presented with painless obstructive jaundice, and the diagnostic and therapeutic strategy that followed.

  7. A Carcinoid Tumor of the Ampulla of Vater Treated by Endoscopic Snare Papillectomy

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    Pyun, Dae-Keun; Moon, Gyoo; Han, Jimin; Kim, Myung-Hwan; Lee, Sang Soo; Seo, Dong-Wan; Lee, Sung-Koo

    2004-01-01

    Here, a case of a patient with incidental finding of a carcinoid tumor of the ampulla of Vater, who was treated with endoscopic snare papillectomy, is reported. A 62-year-old male was admitted to our hospital due to a carcinoid tumor of the ampulla of Vater, which was found during follow-up endoscopy after an endoscopic mucosal resection of early gastric cancer. No lymphadenopathy or visceral metastasis was found on an abdominal CT scan, In-111 octerotide scan and EUS. The ampulla was then en...

  8. [Transduodenal ampullectomy: an useful alternative for the treatment of Vater's ampulla lesions. Case reports of an unfrecuent surgical technique].

    Science.gov (United States)

    Targarona Modena, Javier; Rosamedina, Jose Luis; Garatea, Rafael; Romero, Cesar; Lora, Alfonso; Contardo, Carlos; Mantila, Lidia; Yabar, Alejandro; Montoya, Eduardo

    2005-01-01

    The Vater's ampulla neoplasias are not very frequent lesions. The ampullectomy consists on the total resection of the Vater's ampulla and part of the duodenal wall with the later reconstruction and anastomosis of the common bile duct and the Wirsung's duct to the duodenum. The local resection of the ampulla is an alternative to the duodenopancreatectomy that has to be taken into account, especially in benign lesions as in the case of adenomas of the Vater's ampulla. Here we describe two cases one with adenoma of the Vater's ampulla, with a high degree dysplasia, who first underwent an ampullectomy and finally ended up in a duodenopancreatectomy due to the infiltration of the adenoma into the edge of section and other case of Lymphangioma of Vater's ampulla with no infiltration in the edge of section.

  9. Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater

    Institute of Scientific and Technical Information of China (English)

    Ji-Hong Sun; Ming Chao; Shi-Zheng Zhang; Guang-Qiang Zhang; Bin Li; Jian-Jun Wu

    2008-01-01

    Small cell neuroendocrine carcinoma of the ampulla of Vater is extremely rare and different from the common ampullary adenocarcinoma. The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma. Their coexistence has been rarely reported in the literature. We herein describe an unusual case of a small cell neuroendocrine carcinoma associated with a villous adenoma in the ampulla of Vater with emphasis on computed tomography (CT)and histopathological findings. We also discuss their clinical, histopathological and radiological features as well as possible histogenesis.

  10. A carcinoid tumor of the ampulla of Vater treated by endoscopic snare papillectomy.

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    Pyun, Dae-Keun; Moon, Gyoo; Han, Jimin; Kim, Myung-Hwan; Lee, Sang Soo; Seo, Dong-Wan; Lee, Sung-Koo

    2004-12-01

    Here, a case of a patient with incidental finding of a carcinoid tumor of the ampulla of Vater, who was treated with endoscopic snare papillectomy, is reported. A 62-year-old male was admitted to our hospital due to a carcinoid tumor of the ampulla of Vater, which was found during follow-up endoscopy after an endoscopic mucosal resection of early gastric cancer. No lymphadenopathy or visceral metastasis was found on an abdominal CT scan, In-111 octerotide scan and EUS. The ampulla was then en bloc removed by endoscopic snare papillectomy. The resected specimen revealed a 0.7 x 0.5 x 0.1 cm sized carcinoid tumor. All margins of resection were negative for tumor. After six months of follow-up, there was no evidence of recurrence and metastasis, either endoscopically or radiologically. To our knowledge, this case is the first report of an ampullary carcinoid tumor treated by endoscopic snare papillectomy in Korea.

  11. Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice

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    Filippou Dimitrios

    2006-01-01

    Full Text Available Malignant gastrointestinal stromal tumor (GIST consists a rare neoplasm, developing in small intestine and stomach. The presenting manifastations include weakness, weight loss, nausea, melena and anaemia. The present case refers to a 65 years old female patient with a GIST of the ampulla of Vater presenting with obstructive jaundice. Diagnosis was achieved pre-operatively by biopsies collected through diagnostic ERCP. The tumour was locally excised, with preservation of the ampulla. The histological analysis suggested low grade GIST positive for both CD 117 (c-kit and CD34. Two years after the surgery the patient remains free of disease. Malignant GIST of the ampulla of the Vater is extremely rare as only few similar cases have been described in the literature. This is the first time a GIST being presented as obstructive jaundice ever reported. Despite the unavailability of EUS-FNA, the diagnosis was set preoperatively and the tumor was resected.

  12. Adenocarcinoma of the ampulla of Vater metastasising into the right ventricle.

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    Moser, Magdalena; Wiedemann, Dominik; Kitzwögerer, Melitta; Frank, Herbert

    2016-04-08

    A 43-year-old woman, after resected adenocarcinoma of the ampulla of Vater, presented dyspnoea and beginning signs of right heart failure. Echocardiography revealed a mass within the right ventricle (RV) suspicious for a metastasis of the known adenocarcinoma. The decision for surgical resection was made by cardiovascular MR, which was able to delineate the infiltrative growth of a metastasis. An extensive resection had to be performed. Parts of the intraventricular septum as well as the tricuspid valve had to be resected. After six cycles of adjuvant systemic chemotherapy with gemcitabine and nab-paclitaxel, the patient had no macroscopic tumour recurrence. To our knowledge, this is the first report of a pancreatobiliary tumour metastasising exclusively to the RV of the heart. We conclude that in this special case aggressive surgical management following chemotherapy was very effective in controlling the disseminated adenocarcinoma of the ampulla of Vater.

  13. Carcinoid of the ampulla of Vater: Morphologic features and clinical implications

    Institute of Scientific and Technical Information of China (English)

    George A Poultsides; Wayne AI Frederick

    2006-01-01

    Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice. The published data indicate that these tumors, in contrast to their midgut counterparts, metastasize in approximately half of cases irrespective of primary tumor size. Therefore,radical excision in the form of pancreaticoduodenectomy is recommended regardless of tumor size. As with other gastrointestinal carcinoid tumors, biological treatment with octreotide analogues can be applied to symptomatic patients. Tumor-targeted radioactive therapy is a newly emerging treatment option. We here report case of a carcinoid tumor of the ampulla of Vater presenting as painless jaundice in a 65-year old man and review the relevant literature, giving special attention to the morphologic features, clinical characteristics, and treatment modalities associated with this disease process.

  14. Intradiverticular Ampulla of Vater: Personal Experience at ERCP

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    Girolamo Geraci

    2013-01-01

    Full Text Available Introduction. Conflicting results have been reported about the true impact of intradiverticula ampulla (IA on the technical success and complication rate of endoscopic retrograde cholangiopancreatography (ERCP. Patients. A total of 500 patients who underwent ERCP were divided into two groups according to the presence (group A, 81 patients or absence (group B, 419 patients of IA. Success rate, difficulty at cannulation, findings at ERCP, and procedure-related complications were retrospectively reviewed. Results. Successful cannulation was achieved in 100% of group A patients compared to 98% of group B patients (P = ns. There was a significant difference in the type of cannulation that was routinary in group B (, while requiring guidewire in group A (. Cholangitis (, microstones (, dilated common bile duct without stones (, stone recurrence (, and transient postprocedure hyperamylasemia ( were more frequently observed in group A. There was no significant difference in complication rate between both groups. Conclusions. The finding of an IA at ERCP should not be considered a predictor for failed cannulation. IA is associated with post-ERCP transient hyperamylasemia and is a risk factor for biliary stone disease and its recurrence.

  15. Non-familial double malignancy of the colon and ampulla of vater: A case report and review of literature

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    Rajesh Rajalingam

    2012-01-01

    Full Text Available Apart from their association in familial and hereditary cancer syndromes, sporadic double malignancies of the gastrointestinal tract involving the ampulla of Vater and colon are extremely rare. Although synchronous resection of the two by adding a colectomy to a pancreaticoduodenctomy can be accomplished with minimal increase in the surgical morbidity, a few patients, however, are best managed by a staged resection. We report a case of sporadic double malignancy of the ampulla of Vater and right colon who despite the best attempts continued to bleed and remained malnourished and was successfully managed by staged right hemicolectomy followed by a pancreaticoduodenectomy.

  16. KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression

    Institute of Scientific and Technical Information of China (English)

    Wei Tang; Masatoshi Makuuchi; Yoshinori Inagaki; Norihiro Kokudo; Qian Guo; Yasuji Seyama; Munehiro Nakata; Hiroshi Imamura; Keiji Sano; Yasuhiko Sugawara

    2005-01-01

    AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.

  17. Mucins in neoplasms of pancreas, ampulla of Vater and biliary system

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    Moschovis, Dimitrios; Bamias, Giorgos; Delladetsima, Ioanna

    2016-01-01

    Tumors of the pancreas, the ampulla of Vater, and the extrahepatic and intrahepatic bile ducts have significant histological similarities due to the common embryonic origin of the pancreatobiliary system. This obviates the need for discovery of biomarkers with diagnostic and prognostic value for these tumors. Mucins, especially MUC-1, -2, -4 and -5AC, are important candidates for developing into such reliable biomarkers. Increased expression of MUC1 occurs in pancreatic ductal adenocarcinomas and is associated with increased degrees of dysplasia in pancreatic intraepithelial neoplasia (PanIN). Positive expression of MUC2 in intraductal papillary mucinus neoplasms (IPMN) of the intestinal type indicates high potential progression to invasive carcinoma with de novo expression of MUC1, while absence of MUC2 expression in IPMNs of gastric type implies low potential to malignant evolution. De novo MUC4 expression correlates to the severity of dysplasia in PanIN and is associated with a poor prognosis in patients with pancreatic ductal adenocarcinomas. In biliary intraepithelial neoplasia (BilIN), increased expression of MUC1 is associated with higher degrees of dysplasia. Intrahepatic cholangiocarcinomas (ICC) are characterized by increased expression of all glycoforms of MUC1. Positive MUC2 expression in intraductal papillary neoplasm of the bile ducts (IPNB) of the intestinal type indicates high malignant potential with de novo expression of MUC1 in the invasive element. Absent MUC2 expression in any degree of BilIN may prove useful in differentiating them from IPNB. De novo expression of MUC4 is associated with poor prognosis in patients with ICC or carcinoma of the extrahepatic bile ducts (EHBDC). High de novo expression of MUC5AC is found in all degrees of BilIN and all types of IPNB and ICC. The MUC5AC is useful in the detection of neoplastic lesions of the bile duct at an early stage. Increased expression of mucin MUC1 in carcinoma of the ampulla of Vater

  18. Management of Duodenal Adenomas Involving the Ampulla of Vater – A Warning against Limited Resection

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    Jeremy Rossaak

    2008-03-01

    Full Text Available Duodenal adenomas are uncommon, however, when present a proportion have dysplasia associated with the adenoma and therefore require treatment. The options range from less invasive endoscopic treatments to a pancreaticoduodenectomy. This case report describes two patients with adenomas involving the ampulla of Vater. One patient had familial adenomatous polyposis, the other was a renal transplant patient with a large adenoma. Both patients’ adenomas contained high-grade dysplasia. Both patients underwent a pancreaticoduodenectomy. Histology of both specimens demonstrated that the adenoma had migrated up the bile duct for at least 7 mm, and the pancreatic duct for 8 mm in one patient. Limited resection of ampullary adenomas may leave residual adenomatous tissue in the bile duct with the risk of recurrent adenomatous disease and malignant transformation.

  19. Adenoma viloso com transformação carcinomatosa da ampola de Vater Villous adenoma with carcinomatous degeneration of the ampulla of Vater

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    Guilherme Pinto Bravo Neto

    2001-02-01

    Full Text Available Villous adenomas of the duodenum and ampulla of Vater are uncommon, but they have been diagnosed more frequently with the increasing use of upper gastrointestinal endoscopy. Differential diagnosis with villous adenocarcinoma may be difficult. The authors present a case of a 47-year-old man with a giant villous adenoma of the duodenum, with intermittent jaundice, that was treated by pancreatoduodenectomy.

  20. Metachronous Ampulla of Vater Carcinoma after Curative-Intent Surgery for Klatskin Tumor.

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    Chirita, D; Calita, M; Grasu, M; Dumitru, R; Gramaticu, I; Croitoru, A; Ionescu, M; Dumitrascu, T

    2015-01-01

    Resection represents the single hope for long-term survival in a patient diagnosed with a hilar cholangiocarcinoma (Klatskin tumor). However, the largest part of these patients develops a recurrent disease. Second metachronous periampullary cancers after a curative-intent surgery for a Klatskin tumor represent an exceptional pathology, and the management of these patients was poorly documented. Hereby, it is presented a 32-year-old patient with bile duct resection, left hemi-hepatectomy and loco-regional lymph nodes dissection, for a type IIIB Bismuth-Corlette Klatskin tumor, which, furthermore, 6 years later, underwent a pancreaticoduodenectomy for a metachronous carcinoma of the ampulla of Vater. The management and outcomes were discussed in the reported case, along with a literature review of the previously published patients. In conclusion, a metachronous periampullary carcinoma after resection of a Klatskin tumor should be distinguished from a loco-regional recurrent disease. While most of the patients with recurrences are suitable to only chemotherapy and or radiotherapy, a second curative-intent surgery (i.e., pancreaticoduodenectomy) is feasible in the largest part of the patients with a metachronous cancer, with good long-term outcomes.

  1. MEK inhibitor treatment is effective in a patient with metastatic carcinoma of the ampulla of Vater with BRAF and NRAS mutations shown by next-generation sequencing.

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    Tahover, Esther; Bar Shalom, Rachel; Bogot, Naama; Kelsen, David; Gabizon, Alberto

    2016-07-01

    Here, we present a case of an 84-year-old woman who developed obstructive jaundice and was diagnosed with nonoperable adenocarcinoma originating from the ampulla of Vater, a lethal disease with a median overall survival of less than a year. Her tumor was examined by next-generation sequencing, which showed BRAF and NRAS mutations. To target these mutations, a MEK inhibitor was chosen for treatment. The patient has been treated with a MEK inhibitor for the last 12 months since diagnosis, with clinical and laboratory improvement and manageable side effects. PET-computed tomography imaging has shown stable disease or improvement in the primary and metastatic lesions. This is the first case report of an ampulla of a Vater cancer patient with NRAS and BRAF mutations, identified in next-generation sequencing, and treated successfully with a MEK inhibitor.

  2. Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater: Three-year follow-up of exocrine pancreatic function and clinical symptoms

    Institute of Scientific and Technical Information of China (English)

    Nils Ewald; Axel Michael Marzeion; Reinhard Georg Bretzel; Hans Ulrich Kloer; Philip Daniel Hardt

    2007-01-01

    AIM: To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater.METHODS: After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type I), follow-up examinations were performed in 60 patients (mean follow-up time 37.7 mo). Patients were asked about clinical signs and symptoms at present and before intervention using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determination of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amylase were measured.RESULTS: Eighty percent of patients reported an improvement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (< 200 ng/g) of fecal elastase prior to ES. The levels of serum lipase and amylase as well as serum alcaline phosphatase (AP) and gamma-glutamyltranspeptidase (GGT) decreased significantly after ES.CONCLUSION: The results of this study demonstrate that patients with stenosis of the ampulla of Vater can be successfully treated with endoscopic sphincterotomy. The positive effect is not only indicated by sustained improvement of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function.

  3. Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes

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    G. Perrone

    2010-09-01

    Full Text Available The human equilibrative nucleoside transporter 1 (hENT1 is the major means by which gemcitabine enters human cells; recent evidence exists that hENT1 is expressed in carcinoma of the ampulla of Vater and that it should be considered as a molecular prognostic marker for patients with resected ampullary cancer. Aim of the present study is to evaluate the variations of hENT1 expression in ampullary carcinomas and to correlate such variations with histological subtypes and clinicopathological parameters. Forty-one ampullary carcinomas were histologically classified into intestinal, pancreaticobiliary and unusual types. hENT1 and Ki67 expression were evaluated by immunohistochemistry, and apoptotic cells were identified by the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate biotin nick end labelling (TUNEL method. hENT1 overexpression was detected in 63.4% ampullary carcinomas. A significant difference in terms of hENT1 and Ki67 expression was found between intestinal vs. pancreaticobiliary types (P=0.03 and P=0.009 respectively. Moreover, a significant statistical positive correlation was found between apoptotic and proliferative Index (P=0.036, while no significant correlation was found between hENT1 and apoptosis. Our results on hENT1 expression suggest that classification of ampullary carcinoma by morphological subtypes may represent an additional tool in prospective clinical trials aimed at examining treatment efficacy; in addition, data obtained from Ki67 and TUNEL suggest a key role of hENT1 in tumour growth of ampullary carcinoma.

  4. Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes

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    Perrone, G.; Morini, S.; Santini, D.; Rabitti, C.; Vincenzi, B.; Alloni, R.; Antinori, A.; Magistrelli, P.; Lai, R.; Cass, C.; Mackey, J.R.; Coppola, R.; Tonini, G.; Onetti Muda, A.

    2010-01-01

    The human equilibrative nucleoside transporter 1 (hENT1) is the major means by which gemcitabine enters human cells; recent evidence exists that hENT1 is expressed in carcinoma of the ampulla of Vater and that it should be considered as a molecular prognostic marker for patients with resected ampullary cancer. Aim of the present study is to evaluate the variations of hENT1 expression in ampullary carcinomas and to correlate such variations with histological subtypes and clinicopathological parameters. Forty-one ampullary carcinomas were histologically classified into intestinal, pancreaticobiliary and unusual types. hENT1 and Ki67 expression were evaluated by immunohistochemistry, and apoptotic cells were identified by the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate biotin nick end labelling (TUNEL) method. hENT1 overexpression was detected in 63.4% ampullary carcinomas. A significant difference in terms of hENT1 and Ki67 expression was found between intestinal vs. pancreaticobiliary types (P=0.03 and P=0.009 respectively). Moreover, a significant statistical positive correlation was found between apoptotic and proliferative Index (P=0.036), while no significant correlation was found between hENT1 and apoptosis. Our results on hENT1 expression suggest that classification of ampullary carcinoma by morphological subtypes may represent an additional tool in prospective clinical trials aimed at examining treatment efficacy; in addition, data obtained from Ki67 and TUNEL suggest a key role of hENT1 in tumour growth of ampullary carcinoma. PMID:20839414

  5. Transduodenal ampullectomy in the treatment of villous adenomas and adenocarcinomas of the Vater's ampulla Ampulectomía transduodenal en el tratamiento de los adenomas vellosos y adenocarcinomas de la ampolla de Vater

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    J. A. Fraguela Mariña

    2004-12-01

    Full Text Available Introduction: adenomas are the most frequent tumors of the Vater's ampulla. Their capacity for malignant transformation following the adenoma-carcinoma sequence is well known. It is because of this that resection after diagnosis is required. The identification of the appropriate technique according to tumor features would require that patients not be undertreated or overtreated, which would give rise to serious consequences derived from their location. Patients and methods: villous adenomas and adenocarcinomas of the Vater's ampulla candidates for local resection were revised from January 1st, 1998 through June 30th, 2003. We describe the methods of diagnosis and ampulectomy techniques we performed. Results: we performed an ampulectomy by first intention in all 8 patients included in this study. However, pancreatoduodenectomy was necessary in two patients because of the closeness of resection margins. We had no mortality in this series, and morbidity was limited to two episodes of digestive bleeding that were controlled by electrocoagulation and embolization. The mean follow-up was 28.5 months (range, 6-72 months. Conclusions: the difficulty of precise preoperatory diagnosis in adenomas of the Vater's ampulla demands resection after identification. Ampulectomy is the treatment of choice for villous adenomas and T1 adenocarcinomas, with 1 cm of resection margin to avoid local recurrence.Introducción: los tumores más frecuentes de la ampolla de Vater son los adenomas. Es conocida su capacidad de malignización mediante la secuencia adenoma-carcinoma, por lo que requieren su resección, tras su diagnóstico. El establecimiento de la técnica adecuada según las características del tumor permitiría no infratratar o sobretratar pacientes, con las graves consecuencias que se derivan de ello, debido a su localización. Pacientes y métodos: se revisan los adenomas vellosos y adenocarcinomas de ampolla de Vater subsidiarios de resección local desde

  6. Signet ring cell carcinoma of the ampulla of vater: Report of a case and a review of the literature

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    Masaki Wakasugi

    2015-01-01

    Conclusion: Investigation to confirm the histological origin of SRCC by immunohistochemical staining might inform the treatment strategy and identify patients with ampullary SRCC who may have a good prognosis.

  7. Tumor de colisión periampular Collision tumor of the ampulla of Vater: Carcinoid and adenocarcinoma

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    J. Ferrando Marco

    2007-04-01

    Full Text Available Presentamos un caso de tumor de colisión periampular en el que coexisten un tumor carcinoide de pared duodenal y un adenocarcinoma de cabeza de páncreas. El paciente era un varón de 64 años con historia reciente de diarreas al que se diagnosticó una ictericia obstructiva. Histopatológicamente el tumor resecado mostraba dos neoplasias independientes. Una de ellas constituida por cordones sólidos de células neuroendocrinas que afectaba pared duodenal. La otra está formada por un adenocarcinoma bien diferenciado procedente del páncreas. Ambas neoplasias fueron confirmadas inmunohistoquímicamente. Según la literatura anglosajona revisada tan sólo hemos encontrado seis casos de esta rara coexistencia neoplásica.We report the case of a periampullary collision tumor, in which a duodenal-wall carcinoid and an adenocarcinoma of the head of the pancreas coexisted. We describe the case of a 64-year-old man with a recent history of diarrhea, who was diagnosed with obstructive jaundice. A duodeno-pancreatectomy was performed, and the specimen showed two independent neoplasms in the histopathologic study. Solid cords and nests of neuroendocrine cells in the duodenal wall formed the carcinoid tumor, whereas the other neoplasm was made up of a well-differentiated adenocarcinoma of the pancreas. Both were confirmed by immunohistochemical analysis. According to the literature reviewed, this is the sixth reported case of this rare neoplastic association.

  8. Exceptional Response to Nanoparticle Albumin-Bound Paclitaxel and Gemcitabine in a Patient with a Refractory Adenocarcinoma of the Ampulla of Vater.

    Science.gov (United States)

    Kapp, Markus; Kosmala, Aleksander; Kircher, Stefan; Luber, Verena; Kunzmann, Volker

    2016-01-01

    Ampullary carcinoma is a rare tumor and evidence on the treatment of recurrent metastatic disease is scarce. We report the case of a 60-year-old patient with an R0-resected node-positive adenocarcinoma of the papilla of Vater of an initially diagnosed intestinal subtype who developed pulmonary metastases 2 months after adjuvant gemcitabine chemotherapy and, subsequently, liver metastases. Palliative combination chemotherapy with standard regimens for intestinal-type adenocarcinoma (FOLFOX and FOLFIRI) failed. However, subsequent combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine, a regimen with proven efficacy in metastatic adenocarcinoma of the pancreas, resulted in a durable, very good partial remission. Treatment was manageable and well tolerated. Primary tumor and metastatic tissue were reassessed by immunohistochemistry and had to be reclassified to a mixed phenotype containing predominant elements of the pancreatobiliary subtype. Our case suggests that combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine could represent a promising option for the treatment of this rare disease and warrants further investigation within controlled clinical trials. Moreover, thorough characterization of ampullary carcinomas by histomorphology and additional immunohistochemistry should become mandatory in order to start a chemotherapeutic regimen tailored for the definitive subtype.

  9. Exceptional Response to Nanoparticle Albumin-Bound Paclitaxel and Gemcitabine in a Patient with a Refractory Adenocarcinoma of the Ampulla of Vater

    Directory of Open Access Journals (Sweden)

    Markus Kapp

    2016-01-01

    Full Text Available Ampullary carcinoma is a rare tumor and evidence on the treatment of recurrent metastatic disease is scarce. We report the case of a 60-year-old patient with an R0-resected node-positive adenocarcinoma of the papilla of Vater of an initially diagnosed intestinal subtype who developed pulmonary metastases 2 months after adjuvant gemcitabine chemotherapy and, subsequently, liver metastases. Palliative combination chemotherapy with standard regimens for intestinal-type adenocarcinoma (FOLFOX and FOLFIRI failed. However, subsequent combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine, a regimen with proven efficacy in metastatic adenocarcinoma of the pancreas, resulted in a durable, very good partial remission. Treatment was manageable and well tolerated. Primary tumor and metastatic tissue were reassessed by immunohistochemistry and had to be reclassified to a mixed phenotype containing predominant elements of the pancreatobiliary subtype. Our case suggests that combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine could represent a promising option for the treatment of this rare disease and warrants further investigation within controlled clinical trials. Moreover, thorough characterization of ampullary carcinomas by histomorphology and additional immunohistochemistry should become mandatory in order to start a chemotherapeutic regimen tailored for the definitive subtype.

  10. Unusual histological findings after partial pancreaticoduodenectomy including benign multicystic mesothelioma, adenomyoma of the ampulla of Vater, and undifferentiated carcinoma, sarcomatoid variant: a case series

    Directory of Open Access Journals (Sweden)

    Eisenberger Claus F

    2010-12-01

    Full Text Available Abstract Introduction The standard operation for carcinoma of the pancreatic head is a partial pancreaticoduodenectomy. Unusual histological findings may occasionally occur in the surgical specimen. We present three unusual histologic diagnoses after pancreaticoduodenectomy. Case presentations In the first case, an 86-year-old Caucasian woman was admitted with abdominal pain and nausea. Preoperative evaluation showed a 3 cm cystic lesion in the head of the pancreas. Pathology revealed a benign multicystic mesothelioma. In the second case, a 45-year-old Caucasian man complained of nausea, vomiting and general malaise for several months. Endoscopic retrograde cholangiopancreatographic examination and a computed tomography scan showed a stenosis of the distal bile duct secondary to a mass in the head of the pancreas and duodenum. Histology showed an adenomyoma of the ampulla. In the third case, a 59-year-old Caucasian man presented with chronic alcoholic pancreatitis. A computed tomography scan revealed a 3.5 cm lesion in the head of the pancreas with cystic and solid components. Pathology showed an undifferentiated carcinoma, sarcomatoid variant. Conclusion Partial pancreaticoduodenectomy is usually performed for ductal adenocarcinomas, neuroendocrine tumors or chronic pancreatitis. Compared to the majority of the above diagnoses, the three cases in our study are very rare. Benign multicystic mesothelioma is a very rare tumor that originates from the peritoneum. Although it demonstrates a benign clinical behaviour, it frequently recurs after resection. Adenomyoma of the bile duct or ampullary region is a very unusual, benign, localized lesion characterized by adenomyomatous hyperplasia. Undifferentiated carcinoma, sarcomatoid variant, is an aggressive tumor and is characterized by spindle cells. As the lesions were suspicious for carcinoma, partial pancreaticoduodenectomy was justified in all three patients. The histologic diagnosis after partial

  11. MelanomaintheampullaofVater

    Institute of Scientific and Technical Information of China (English)

    Antonia Bendic; Merica Glavina Durdov; Radoslav Stipic; Ivana Karaman

    2013-01-01

    BACKGROUND: The most common tumors in the ampulla of Vater are adenocarcinomas. Although malignant melanoma usually occurs on the skin, it can also arise in the gastrointestinal and biliary tract. METHOD: We present a case of a 52-year-old, previously healthy man who presented with painless jaundice. RESULTS: Clinical examination revealed dilated intrahepatic and extrahepatic bile ducts and pancreatic duct due to the obstructive mass in the ampulla of Vater. The patient underwent pancreaticoduodenectomy and histopathological diagnosis of the resected tumor mass was malignant melanoma. Thorough clinical examination was preformed, but no other primary or metastatic site of melanoma could be found. In the next few months, the patient developed multiple liver metastases and died. CONCLUSION: An isolated amelanotic lesion in the ampulla of Vater can be a potential diagnostic pitfall, especially in patients who have had melanoma.

  12. Endoscopic papillectomy for tumors at ampulla of Vater%经内镜十二指肠乳头切除术治疗乳头部肿瘤的临床价值

    Institute of Scientific and Technical Information of China (English)

    覃华; 赵秋; 李德民; 王波; 李荣香; 张敏; 胡继芬; 王渝

    2012-01-01

    Objective To assess the feasibility,safety and efficacy of endoscopic papillectomy (EP) for tumors at the ampulla of Vater (AV).Methods A total of 15 patients with tumor at AV that were indicated for EP were included in this prospective study.Their clinical profiles,procedural parameters and outcome were evaluated.Results All patients underwent EP procedure successfully.Four patients who were diagnosed as having chronic inflammation in the reference endoscopy were confirmed as having adenoma after EP.Out of the 11 patients who were previously diagnosed as andenoma on biopsy,2 of low differentiated adenocarcinoma,1 of well differentiated adenocarcinoma and 1 malignant transformation were pathologically confirmed after EP.Stents were implanted in 8 patients with dilated pancreatic and/or common bile duct.Except for 2 cases of melena and 2 transient elevated level of blood amylase after EP,no other major complications occurred.Three patients,including 1 case of low-differentiated adenocarcinoma,1 case of malignant transformation and 1 case of lesion residual,were referred to surgery,another patient with low-differentiated adenocarcinoma declined any additional intervention because of old age.In the remaining 11 cases ( 11/15,73.3% ) including one well differentiated adenocarcinoma,no recurrence was observed during a follow-up period of 23.4 (5 to 47) months.Conclusion EP is a minimal invasive,safe and effective treatment for tumors at AV,which also can provide an accurate staging of the lesion.%目的 探讨经内镜十二指肠乳头切除术(EP)治疗十二指肠乳头部肿瘤的临床价值.方法 前瞻性观察研究15例经EP治疗的十二指肠乳头部肿瘤患者的临床疗效、并发症及随访观察结果,评价其临床价值.结果 所有15例患者均顺利完成EP治疗,其中4例术前病检为慢性炎症者术后病理诊断为腺瘤;11例术前病检为腺瘤者中术后病理诊断为高分化腺癌1例、低分化腺癌2

  13. Composite neuroendocrine and adenomatous carcinoma of the papilla of Vater

    Institute of Scientific and Technical Information of China (English)

    Joanna A Musialik; Maciej J Kohut; Tomasz Marek; Anatol Wodo(I)a(z)ski; Marek Hartleb

    2009-01-01

    Malignant tumors of papilla are usually adenocarcinomas.We present a 67-year-old female who became icteric as result of a malignant tumor infiltrating the papilla of Vater. Histopathological assessment of surgically excised tumor showed both neuroendocrine and adenocarcinomatous features. To our knowledge, this is the seventh report of this rare neoplastic association in the duodenal periampullary region.

  14. Acute Recurrent Pancreatitis: A Possible Clinical Manifestation of Ampullary Cancer

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    Athanasios Petrou

    2011-11-01

    Full Text Available Context Acute recurrent pancreatitis still poses diagnostic difficulties. The coexistence or moreover the causative relationship of carcinoma of the ampulla of Vater and acute recurrent pancreatitis is fairly rare. Case report We present a case of carcinoma of the ampulla of Vater that presented with acute recurrent necrotizing pancreatitis complicated with pseudocysts. A diagnosis of malignancy in the ampulla was only made after several ERCP attempts due to residual inflammation at the periampullary area. Conclusion Malignancy at the ampulla of Vater causing recurrent episodes of pancreatitis represents a realistic risk and attempts to diagnose the underlying cause should always take into account the possibility of cancer.

  15. Morphological observations of ampullae of lorenzini in Squatina guggenheim and S. occulta (Chondrichthyes, Elasmobranchii, Squatinidae).

    Science.gov (United States)

    Tavares Schäfer, Bárbara; Malavasi, Carlos Eduardo; Favaron, Phelipe Oliveira; Ambrósio, Carlos Eduardo; Miglino, Maria Angelica; Ferreira De Amorim, Alberto; Grassi Rici, Rose Eli

    2012-09-01

    We have conducted a morphological study of the ampullae of Lorenzini on two shark species from Squatina Genus. In both species, S. guggenheim and S. occulta, the ampullae were observed like small pores scattered in the head region similar to other species of the Chondrichthyes Class. However, differently of the other species a greatest density of ampullae of Lorenzini was observed along of the body surface. After fixation using 10% formaldehyde, the ampullae were removed and processed for light and scanning electron microscopy. Macroscopically, the two shark species differed by the presence of dorsal spines that appeared from the head to the first dorsal fin in S. guggenheim and were absent in S. occulta. Microscopically, there were no differences between the ampullae of Lorenzini channels in these two species. The wall of the ampulla was formed by a simple squamous epithelium. Bands of connective tissue, hyaline cartilage and collagen fibers were found between the ampulla and the skeletal striated muscle layer. Nerve branches responsible for conducting signal pulses to the central nervous system were visible between the muscle and connective tissue layers. Using scanning electron microscopy and histological analysis, we found that the channels were twisted and positioned parallel to the skin. The inside of the channels contained a large amount of a gelatinous secretion composed by polysaccharides. Therefore, we conclude that the morphological combination of extended distribution of the ampullae of Lorenzini and the body shape may represent an adaptation of these species to their way of life.

  16. Assessment of takotsubo (ampulla) cardiomyopathy using iodine-123 metaiodobenzylguanidine scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Pessoa, Pinheiro M.C.; Xavier, Salles S.; Lima, Souza Leao R.; Mansur, J.; Almeida, Altino S. de; Carvalho, Pires A.C.; Gutfilen, B.; Fonseca, Barbosa L.M. da [Hospital Univ. Clementino Fraga Filho, Univ. Federal do Rio de Janeiro (Brazil). Dept. de Radiologia

    2006-12-15

    Purpose: To evaluate the role of cardiac sympathetic innervation in patients whose clinical features consisted of chest pain, transient ST-segment elevation, left ventricular apical akinesis, minimal elevation of cardiac enzymes, and onset of symptoms shortly after a severe stress condition. Material and Methods: Five female patients, mean age 67{+-}14 years, underwent thoracic {sup 123}I-MIBG (planar and SPECT) and 67Ga citrate (planar) scans within 5 days after the onset of symptoms. The {sup 123}I-MIBG myocardial washout rate between early (30 min) and delayed (3 hours) planar images was calculated. All patients presented findings consistent with takotsubo-like syndrome. Echocardiograms showed the characteristic wall motion pattern of significant apical dysfunction. Acute-phase coronary angiographies revealed a non-obstructive pattern. A peculiar apical akinesis and basal normokinesis were observed on the ventriculograms. Results: Impairment of cardiac neuronal uptake of {sup 123}I-MIBG based on a reduction of the heart-to-mediastinum uptake ratio was observed in all patients, while the washout rate was raised in four patients. All patients presented an apical uptake defect in the {sup 123}I-MIBG SPECT and planar images and a normal 67Ga scintigraphy. Conclusion: Our data indicate that ampulla cardiomyopathy (AC) is associated with a cardiac sympathetic innervation deficit characterized by a reduced global {sup 123}I-MIBG uptake and an apical uptake defect. The lack of 67Ga uptake in the acute phase of this syndrome indicates that AC is probably not associated with an inflammatory process.

  17. Modifications of carbohydrate residues in the sheep oviductal ampulla after superovulation.

    Science.gov (United States)

    Desantis, S; Accogli, G; Silvestre, F; Binetti, F; Caira, M; Lacalandra, G M

    2015-04-01

    Epithelium of oviductal ampulla was studied in normal and in superovulated sheep using morphologic analysis and lectin glycohistochemistry. The lining epithelium consisted of two types of cells, ciliated and nonciliated cells. Unlike superovulated samples, the nonciliated cells from control ewes showed apical protrusions indicating an apocrine secretory activity. The ciliated cells showed lectin-binding sites mainly at the level of the cilia which bound all the used lectins except Peanut agglutinin, suggesting the lack of glycans terminating with Galβ1,3GalNAc. In superovulated specimens, the ciliated cells with high mannosylated glycans Concanavalin A (Con A) and GlcNAc and GalNac termini Griffonia simplicifolia agglutinin II (GSA II) and Dolicurus biflorus agglutinin (DBA) decreased. The luminal surface of nonciliated cells showed all investigated sugar residues in controls, whereas it was lacking in high mannosylated (Con A) and terminal GalNAcα1,3(LFucα1,2)Galβ1,3/4GlcNAcβ1 sequence (DBA) in superovulated ewes. Apical protrusions from control ampullae nonciliated cells showed glycans containing mannose, GlcNac, GalNAc, galactose, and α2,3-linked sialic acid (Con A, KOH-sialidase- Wheat germ agglutnin [WGA], GSA II, SBA, Griffonia simplicifolia agglutinin-isolectin B4 [GSA I-B4], Maackia amurensis agglutinin II [MAL II]). The supranuclear cytoplasm of nonciliated cells expressed terminal GlcNAc (GSA II) in all specimens, also O-linked glycans (mucin-type glycans) with GalNAc and sialic acid termini (Helix pomatia agglutinin [HPA] and MAL II) in control animals, and also N-linked glycans with fucose, galactose, lactosamine, and α2,3-linked sialic acid termini (Ulex europaeus agglutinin I [UEA I], GSA I-B4, Ricinus communis agglutinin120 [RCA120], and Sambucus nigra agglutinin [SNA] ) in superovulated ewes. These results report for the first time that the superovulation treatment affects the secretory activity and the glycan pattern of the epithelium lining

  18. Changes of ampulla pressure in the semicircular canal of pigeons by caloric stimulation

    Science.gov (United States)

    Wada, Yoshiro; Suzuki, Hiroyuki; Watanabe, Satoru

    Still now several hypotheses about the mechanisms of the caloric nystagmus have been in conclusive. In this study we confirmed the convection effect and the volume change effect of the endolymph in horizontal semicircular canal following the caloric stimulation using pigeons ( Columba livia). Although the direction of the caloric nystagmus depended on the head position and the stimulus site of calorization, the caloric nystagmus disappeared after plugging of horizontal semicircular canal. On the other hand, the ampulla pressure increased by cold calorization and decreased by hot calorization and these pressure changes had no relation to the head position. These results show that the main role of the mechanisms of the caloric nystagmus under 1G is the convection effect but the volume change effect may act on the caloric nystagmus not only under 1G but also under microgravity.

  19. Perforation of the Papilla of Vater in Wire-Guided Cannulation

    Directory of Open Access Journals (Sweden)

    Yuichi Takano

    2016-01-01

    Full Text Available Background. WGC in ERCP is considered a safe technique, although rare complications can occur. One unique complication of WGC is the perforation of the papilla of Vater by the guidewire. Subjects and Methods. Of 2032 patients who underwent ERCP at our department between January 2010 and December 2014, we selected 208 patients who underwent WGC for naïve papilla as subjects. A detailed examination of patients in whom a perforation occurred was conducted, and risk factors for perforations were investigated. Results. The perforation was observed in 7 of 208 patients (3.4%. All patients recovered with conservative treatment without the need for surgery. The perforation rate was significantly higher in the patients with juxtapapillary duodenal diverticula than those without diverticula (12.5% versus 0.6%, p<0.001. Cannulation of the bile duct was ultimately achieved in 5 of 7 patients; PSP was performed for 4 of these patients. Conclusion. Caution must be exercised when dealing with patients who have a juxtapapillary duodenal diverticula because they are at higher risk of perforations. Because these are small perforations made by a wire, most of them heal with conservative treatment. However, perforations can make cannulation difficult, and PSP may be useful for deep cannulation.

  20. Differential lectin binding patterns in the oviductal ampulla of the horse during oestrus

    Directory of Open Access Journals (Sweden)

    S Desantis

    2009-06-01

    Full Text Available We investigated the oligosaccharide sequence of glycoconjugates, mainly sialoglycoconjugates, in the horse oviductal ampulla during oestrus by means of lectin and pre-lectin methods such as the KOH-neuraminidase procedure to remove sialic acid residues and incubation with N-glycosidase F to cleave N-linked glycans. Ciliated cells displayed Nlinked oligosaccharides throughout the cytoplasm. The cilia glycocalyx expressed both N- and O-linked (mucin-type oligosaccharides, both showing a high variety of terminal sequences. In the most non-ciliated cells, the whole cytoplasm contained N-linked oligosaccharides with terminal aGal as well as mucin-type glycans with terminal Forssman pentasaccharides. In a few scattered non-ciliated cells, the whole cytoplasm displayed sialylated N-linked oligosaccharides with terminal Neu5Ac-GalNAc and O-linked glycans terminating with neutral and/or aGalNAc, Neu5Aca2,6Gal/ GalNAc, Neu5AcGalb1,3GalNAc. Supra-nuclear granules, probably Golgi zones, of non-ciliated cells showed mainly Olinked glycans rich in sialic acid residues. The luminal surface of non-ciliated cells showed N-linked oligosaccharides, containing terminal/internal aMan/aGlc, bGlcNAc and terminal aGal, as well as mucin-type oligosaccharides terminating with a large variety of either neutral saccharides or sialylated sequences. Apical protrusions containing O-linked oligosaccharides with terminal Forssman pentasaccharide, Neu5Ac-Galb1,4GlcNAc, Neu5Ac-GalNAc were seen in nonciliated cells scattered along the epithelium. These findings show the presence of sialoglycoconjugates in the oviductal ampulla epithelium of the mare and the existence of different lectin binding profiles between ciliated and non-ciliated (secretory cells, as well as the presence of non-ciliated cell sub-types which might determine functional differences along the ampullary epithelium of mare oviduct.

  1. VACTERL/VATER Association

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    Solomon Benjamin D

    2011-08-01

    Full Text Available Abstract VACTERL/VATER association is typically defined by the presence of at least three of the following congenital malformations: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities. In addition to these core component features, patients may also have other congenital anomalies. Although diagnostic criteria vary, the incidence is estimated at approximately 1 in 10,000 to 1 in 40,000 live-born infants. The condition is ascertained clinically by the presence of the above-mentioned malformations; importantly, there should be no clinical or laboratory-based evidence for the presence of one of the many similar conditions, as the differential diagnosis is relatively large. This differential diagnosis includes (but is not limited to Baller-Gerold syndrome, CHARGE syndrome, Currarino syndrome, deletion 22q11.2 syndrome, Fanconi anemia, Feingold syndrome, Fryns syndrome, MURCS association, oculo-auriculo-vertebral syndrome, Opitz G/BBB syndrome, Pallister-Hall syndrome, Townes-Brocks syndrome, and VACTERL with hydrocephalus. Though there are hints regarding causation, the aetiology has been identified only in a small fraction of patients to date, likely due to factors such as a high degree of clinical and causal heterogeneity, the largely sporadic nature of the disorder, and the presence of many similar conditions. New genetic research methods offer promise that the causes of VACTERL association will be better defined in the relatively near future. Antenatal diagnosis can be challenging, as certain component features can be difficult to ascertain prior to birth. The management of patients with VACTERL/VATER association typically centers around surgical correction of the specific congenital anomalies (typically anal atresia, certain types of cardiac malformations, and/or tracheo-esophageal fistula in the immediate postnatal period, followed by long-term medical management of sequelae of

  2. Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater

    Institute of Scientific and Technical Information of China (English)

    Klaus L Prenzel; Ute Warnecke-Eberz; Jan Brabender; Stephan E Baldus; Elfriede Bollschweiler; Christian A Gutschow; Uta Drebber; Arnulf H Hoelscher; Paul M Schneider

    2006-01-01

    AIM: We examined quantitative mRNA expression of growth factor receptors (c-erbB-1, c-erbB-2) and the anti-apoptosis gene survivin known to be regulated in pancreatic adenocarcinomas and compared the expression pattern with that in carcinomas of the papilla of Vater.METHODS: Quantitative real-time reverse transcriptasePCR (QRT-PCR, TaqmanTM) was performed to analyze mRNA expression levels of c-erbB-1, c-erbB-2 and survivin in normal and corresponding tumor samples of 31 pancreatic adenocarcinomas and 8 cancers of the papilla of Vater.RESULTS: The overall median mRNA expression of survivin was significantly increased in both adenocarcinoma of the pancreas (P<0.01) and papilla of Vater (P<0.008) compared with uninvolved normal control tissue. In pancreatic cancer, expression of c-erbB-1 was significantly decreased compared with the normal pancreatic tissue (P<0.03), whereas in the cancer of the papilla of Vater expression of c-erbB-2 was significantly downregulated (P<0.05) compared with the paired normal samples. Gene expression was not associated with tumor stage, differentiation or prognosis.CONCLUSION: The common anti-apoptosis gene survivin is overexpressed both in the cancer of the papilla of Vater and pancreas. In contrast, the growth factor receptor genes c-erbB-1 and c-erbB-2 are differentially regulated in both tumor entities adding further evidence that pancreatic cancer is biologically different from the cancer of papilla of Vater.

  3. Die Entdeckung der Differenz: Zur Besonderheit des Vaters für das Kind The Discovery of Difference: On the Noteworthiness of the Father for his Child

    Directory of Open Access Journals (Sweden)

    Beate Kortendiek

    2003-07-01

    Full Text Available In dem Sammelband wird in zehn Beiträgen aus psychoanalytischer und -therapeutischer sowie bindungs- und systemtheoretischer Perspektive nach der Bedeutung des Vaters für Säugling und Kleinkind gefragt. Hierbei geht es u.a. um die Analyse von Vaterlosigkeit, Bindungsentwicklungen, Spielsituationen und Schlafstörungen unter besonderer Berücksichtung der Entwicklung dyadischer und triadischer Beziehungen zwischen Vater, Mutter und Kind. Die Berichte sind von Wissenschaftler/-innen und Therapeut/-innen aus Österreich, Deutschland und der Schweiz verfasst und gehen zurück auf die Jahrestagung (2001 der „Deutschen Gesellschaft für die seelische Gesundheit in der frühen Kindheit“ (Germanspeeking Association für Infant Mental Health/GAIMH. Die Veröffentlichung ermöglicht einen Überblick über die aktuelle psychologisch orientierte Forschung und Debatte der frühen Beziehung zwischen Vater und Kind.The ten contributions to this anthology all address the relevance of the father for the baby and infant, employing psychoanalytical and therapeutic perspectives, as well as attachment theory and systemic theory. Among other things, the texts analyse growing up without a father, developing attachment, child play, and sleep disorders with a special focus on the development of dyadic and triadic relations between father, mother, and child. The individual reports were written by scientists and therapists in Austria, Germany, and Switzerland, and were inspired by the 2001 annual Meeting of the “German Speaking Association for Infant Mental Health (GAIMH.” This publication offers an overview of current psychological research and debates about early father-child relationships.

  4. Safe endoscopic resection of gangliocytic paraganglioma of the major duodenal papilla Ampulectomía endoscópica eficaz de un paraganglioma gangliocítico localizado en la papila de Vater

    Directory of Open Access Journals (Sweden)

    P. Sánchez-Pobre

    2004-09-01

    Full Text Available A case of gangliocytic paraganglioma of the papilla of Vater in a 76-year-old man with a history of recurrent obstructive jaundice is presented. This is the first case of gangliocytic paraganglioma of the major papilla succesfully resected by endoscopic ampullectomy.Se describe un caso de paraganglioma gangliocítico de la papila de Vater, en un varón de 76 años, manifestado con cuadros de ictericia obstructiva recidivante. Este es el primer caso descrito de paraganglioma de la papila mayor resuelto eficazmente mediante ampulectomía endoscópica.

  5. Complete Resection of Ampullary Paragangliomas Confined to the Submucosa on Endoscopic Ultrasound May Be Best Achieved by Radical Surgical Resection

    Directory of Open Access Journals (Sweden)

    Kevin A. Ghassemi

    2009-06-01

    Full Text Available Paragangliomas of the gastrointestinal tract generally are benign tumors usually found in the second portion of the duodenum. We present a case of paraganglioma of the ampulla of Vater confined to the submucosa on endoscopic ultrasound examination. This was initially treated by endoscopic resection, followed by pancreaticoduodenectomy after local resection margins were positive. Histopathology showed a well-differentiated ampullary paraganglioma confined to the submucosa, but with involvement of one regional lymph node. Only 25 prior cases of paraganglioma at the ampulla of Vater have been reported, and nine of these have demonstrated local or distant metastases. Because of their malignant potential, ampullary paragangliomas should be treated with radical resection if the goal is to achieve complete resection, even if preoperative imaging shows local confinement.

  6. Assessment of Takotsubo (ampulla) cardiomyopathy using {sup 99m}Tc-tetrofosmin myocardial SPECT. Comparison with acute coronary syndrome

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    Ito, Kazuki; Katoh, Shuji [Asahi Univ., Gifu (Japan). Murakami Memorial Hospital; Sugihara, Hiroki; Azuma, Akihiro; Nakagawa, Masao [Kyoto Prefectural Univ. of Medicine (Japan)

    2003-04-01

    We assessed Takotsubo (ampulla) cardiomyopathy compared with acute coronary syndrome (ACS) using two-dimensional echocardiography and {sup 99m}Tc-tetrofosmin myocardial SPECT. We examined 10 patients with Takotsubo cardiomyopathy and 16 with ACS at the time of emergency admission (acute phase), at three to nine days after the attack (subacute phase) and at one month after the attack (chronic phase). The left ventricle was divided into nine regions on echocardiograms and SPECT images, and the degree of abnormalities in each region was scored in five grades from normal (0) to severely abnormal (4). Coronary angiography revealed total or subtotal occlusion in patients with ACS but no stenotic legions in those with Takotsubo cardiomyopathy. The amount of ST segment elevation (mm) was 7.9{+-}3.4 in patients with Takotsubo cardiomyopathy and 7.3{+-}3.7 in those with ACS (N.S.). Abnormal wall motion scores on echocardiograms were 13.8{+-}4.4, 4.4{+-}3.8 and 1.8{+-}2.3 during the acute, subacute and chronic phases in patients with Takotsubo cardiomyopathy, and 13.9{+-}4.0, 11.7{+-}3.7, 7.6{+-}4.2, respectively in patients with ACS. The value of MB fraction of creatine phosphokinase (IU/l) was 34{+-}23 in patients with Takotsubo cardiomyopathy and 326{+-}98 in those with ACS (p<0.001). Abnormal myocardial perfusion scores on {sup 99m}Tc-tetrofosmin myocardial SPECT were 11.4{+-}3.2, 3.2{+-}3.3 and 0.7{+-}1.1 during the acute, subacute and chronic phases respectively, in patients with Takotsubo cardiomyopathy, and 15.8{+-}4.1, 13.5{+-}4.4, 8.2{+-}4.4, respectively, in those with ACS. The numbers of myocardial segments that did not uptake {sup 99m}Tc-tetrofosmin during the acute phase were 0.5{+-}0.8 and 3.6{+-}2.8 in patients with Takotsubo cardiomyopathy and ACS, respectively. Impaired coronary microcirculation might be a causative mechanism of Takotsubo cardiomyopathy. (author)

  7. Shell Colour Polymorphism in Bulla ampulla

    DEFF Research Database (Denmark)

    Cedhagen, Tomas

    1999-01-01

    Colour patterns of Bulla ampulla shells collected from Africa eastward to Pacific Islands were studied. 1\\vo common colour morphs were found. The typical morph is commonest. It is closely and finely mottled or all over with pinkish-gray on a creamy or flesh~tinted ground, with darker clouds......, irregular, V-shaped, or as longitudinal bands. The colouration of the other common morph is more uniform. It is lacking the darker clouds or bands and the colour is more greyish. The entire shell surface is densely mottled all over with small brown spots on a grey or beige background. Both morphs seem...

  8. Diagnostic Value of Ultrasonic Testing in Ampulla-type Renal Pelvis%超声检查在壶腹肾盂诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    马佳; 王萍; 卢金生

    2012-01-01

    Objective To analyze 1he ultrasound phenomenon of ampulla-type renal pelvis, and improve its ultrasound diagnostic accuracy rate . M eihods U ltrasound perform ance of 30 am pulla-type renal pelvis w hich w ere diagnosed Ihrough C T scan or X -ray intravenous pyebgram w as retrospective analyzed . Results The representation of am pulla-type renal pelvis is oval, obtuse triangle, shuttle shape or branches type, mainly wilh m ild-to-moderate set separation system ,and 1here were no sense of tension of 1he renalpelvis . Conclusion Full understanding 1he ultrasonographic feature of ampulla-type renal pelvis can help reducing 1he m isdiagnosis rate of ultrasonic .%目的 分析壶腹型肾盂的超声表现,提高壶腹肾盂的超声诊断正确率.方法 回顾分析30例经CT扫描或X线静脉肾盂造影证实的壶腹型肾盂的超声学表现.结果 壶腹肾盂表现为卵圆形、钝角三角形、梭型及树枝型,以轻中度集合系统分离为主,肾盂均无张力感.结论 充分了解壶腹型肾盂的声像图特点,可以帮助减少超声对壶腹肾盂的误诊率.

  9. Der Vater in der Eltern-Kleinkind-Psychotherapie

    OpenAIRE

    Barrows, Paul

    2000-01-01

    In dieser Arbeit wird diskutiert, daß und warum die Rolle des Vaters sowohl von Forschern als auch von Eltern-Kleinkind-Therapeuten bisher nur wenig beachtet wird und warum der Vater für die Entwicklung des Kindes bedeutsam ist. Anhand von Fallbeispielen wird gezeigt, daß der Vater häufig in die therapeutische Arbeit eingebunden werden muß, damit die Therapie erfolgreich sein kann. Zwei besondere Aspekte der Funktion des Vaters werden dargestellt: der direkte Einfluß seiner "Gespenster" auf d...

  10. Significance of cytomorphological and microbiological examination of bile collected by endoscopic cannulation of the papilla of vater

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    Misra Vatsala

    2009-07-01

    Full Text Available Background: Bile analysis yields important information such as "biliary microlithiasis" and biliary tract colonization by microorganisms like Salmonella typhi or paratyphi, Escherichia coli , etc., which may progresses to cholelithiasis and have been found to have a role in the development of gallbladder cancer in India. Aim: To perform microscopic, cytomorphological and microbiological examination of bile collected during endoscopic retrograde cholangiopancreatography in patients with benign and malignant lesions of the gallbladder. Materials and Methods: Bile was collected from 48 patients by a catheter inserted through the cystic duct during endoscopic retrograde cholangiopancreatography. Direct microscopy and grading of crystals was performed. Smears prepared from centrifuged deposits were stained with Giemsa, Papanicolaou stain and Gram′s stain for cytological and microbiological examination. Special staining for Helicobacter pylori was performed using Loeffler′s Methylene blue and Warthin Starry stain. The rest of the sample was used for culture and complete microbiological examination. Results: Thirty-six patients had inflammatory lesions while 12 had malignant lesions. Crystals were observed in 93% of the cases, 13 (28.8% had only cholesterol crystals, three (6.6% had bilirubinate and 29 (64.4% had both cholesterol and bilirubinate crystals. Smears from the centrifuged deposit mainly showed coccoid or cocobacillary bacteria on Gram′s staining (81.3%. Five of 12 (41.6% malignant cases showed epithelial atypia while none of the benign or inflammatory lesions showed such a change in hematoxylin and eosin and Pap-stained smears. Microbiologic analysis showed Staphylococcus aureus (14%, S. saprophyticus (5.5%, Peptococcus (5.5%, Peptostreptococcus (5.5%, Proteus mirabilis (5.5%, E. coli (17%, Enteorbacter cloacae (5.5% and H. pylori (2.8%. Conclusion: Complete microscopic and microbiological examination of bile directly obtained from

  11. Optimization of the generator settings for endobiliary radiofrequency ablation

    Institute of Scientific and Technical Information of China (English)

    Maximilien; Barret; Sarah; Leblanc; Ariane; Vienne; Alexandre; Rouquette; Frederic; Beuvon; Stanislas; Chaussade; Frederic; Prat

    2015-01-01

    AIM:To determine the optimal generator settings for endobiliary radiofrequency ablation. METHODS:Endobiliary radiofrequency ablation was performed in live swine on the ampulla of Vater,the common bile duct and in the hepatic parenchyma. Radiofrequency ablation time,"effect",and power were allowed to vary. The animals were sacrificed two hours after the procedure. Histopathological assessment of the depth of the thermal lesions was performed. RESULTS:Twenty-five radiofrequency bursts were applied in three swine. In the ampulla of Vater(n = 3),necrosis of the duodenal wall was observed starting with an effect set at 8,power output set at 10 W,and a 30 s shot duration,whereas superficial mucosal damage of up to 350 μm in depth was recorded for an effect set at 8,power output set at 6 W and a 30 s shot duration. In the common bile duct(n = 4),a 1070 μm,safe and efficient ablation was obtained for an effect set at 8,a power output of 8 W,and an ablation time of 30 s. Within the hepatic parenchyma(n = 18),the depth of tissue damage varied from 1620 μm(effect = 8,power = 10 W,ablation time = 15 s) to 4480 μm(effect = 8,power = 8 W,ablation time = 90 s). CONCLUSION:The duration of the catheter application appeared to be the most important parameter influencing the depth of the thermal injury during endobiliary radiofrequency ablation. In healthy swine,the currently recommended settings of the generator may induce severe,supratherapeutic tissue damage in the biliary tree,especially in the high-risk area of the ampulla of Vater.

  12. Angiodysplasia in gaint diverticulum of transverse duodenum causing massive gastrointestinal bleeding: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Pil Yeob; Lee, Sang Wook; Kwon, Jae Soo; Sung, Young Soon; Rho, Myoung Ho; Hwon, Oh Joon [Sungkyunkwan Univ. College of Medicine, Seoul (Korea, Republic of)

    1998-12-01

    The incidence of duodenal diverticulum found incidentally during upper gastrointestinal roentgenographic examination varies between 2% and 5%. The majority of cases occur along the medial aspect of the second portion of the duodenum, within 2.5 cm of the ampulla of Vater. The majority of duodenal diverticual are asymptomatic, but in some cases, complications such as diverticulitis, hemorrhage, perforation, and fistula formation occur in the third and fourth portions of the duodenum. We describe a case of giant diverticulum of the transverse duodenum, revealed by UGI and angiography, massive gastrointestinal bleeding in a 80-year-old patient.=20.

  13. Complications of gallstones: the Mirizzi syndrome, gallstone ileus, gallstone pancreatitis, complications of "lost" gallstones.

    Science.gov (United States)

    Zaliekas, Jill; Munson, J Lawrence

    2008-12-01

    Gallstones cause various problems besides simple biliary colic and choplecystitis. With chronicity of inflammation caused by gallstone obstruction of the cystic duct, the gallbladder may fuse to the extrahepatic biliary tree, causing Mirizzi syndrome, or fistulize into the intestinal tract, causing so-called gallstone ileus. Stones may pass out of the gallbladder and travel downstream through the common bile duct to obstruct the ampulla of Vater resulting in gallstone pancreatitis, or pass out of the gallbladder inadvertently during surgery, resulting in the syndromes associated with lost gallstones. This article examines these varied and complex complications, with recommendations for management based on the literature, the data, and perhaps some common sense.

  14. Obscure Gastrointestinal Bleeding from an Ampullary Tumour in a Patient with a Remote History of Renal Cell Carcinoma: A Diagnostic Conundrum

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    Rhonda M Janzen

    1998-01-01

    Full Text Available Metastasis of renal cell carcinoma to the ampulla of Vater is a rare occurrence. The outlined case, which presented as an upper gastrointestinal bleed, is only the eighth such reported case in the English-language literature. This case is the longest reported time interval between surgical nephrectomy to presentation with ampullary metastasis at 17.5 years. The ampullary source of bleeding in this case was initially obscure and missed by conventional gastroscopy. Diagnosis was made with a side-viewing endoscope, emphasizing the usefulness of this instrument in the investigation of active bleeding from a small bowel source.

  15. Dilatación de la papila de Vater con balón de gran diámetro para la extracción de coledocolitiasis Large balloon dilation for removal of bile duct stones

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    J. Espinel

    2008-10-01

    Full Text Available Objetivo: valorar la eficacia y seguridad de la dilatación de la papila de Vater con balones de gran diámetro (BGD para la extracción de coledocolitiasis en pacientes con factores que dificultan o hacen peligrosa la extracción, por las características de los cálculos o de la anatomía peripapilar. Diseño: prospectivo. Pacientes: estudio que incluye 93 pacientes a los que se realizó dilatación hidrostática de la papila con balones de gran diámetro entre junio de 2005 y enero de 2008 por presentar cálculos de gran tamaño, múltiples, colédoco distal afilado, papila peri/intradiverticular, esfinterotomía previa o Billroth-II. Se emplearon dilatadores CRE de diámetros entre 12 y 20 mm. Resultados: se consiguió la extracción de los cálculos en una sesión en todos los pacientes (100%. La mayor parte de las exploraciones (86% no requirieron tiempos prolongados para la extracción. Se precisó litotricia en el 3,2%. Hubo dos complicaciones leves (2,1%. Se detectó hiperamilasemia en el 16% de los pacientes. Conclusiones: la dilatación de la papila de Vater con balón de gran diámetro es una técnica eficaz y segura en la extracción de cálculos difíciles de la vía biliar, sin incrementar el tiempo de la exploración, ni las complicaciones, evitando la necesidad de litotricia en la mayoría de los pacientes.Aim: to assess the efficacy and safety of dilatation of the papilla of Vater with large balloons for the treatment of choledocolithiasis in patients with difficult or risky extraction due to stone characteristics or peripapillary anatomy. Design: prospective. Patients: this study includes 93 patients in whom large-balloon dilation was performed between June 2005 and January 2008. Patients had multiple large stones, tapered distal CBD (common bile duct, peri-/intra-diverticular papilla, and previous sphincterotomy or Billroth-II surgery. A controlled radial expansion (CRE balloon with a diameter range of 12-20 mm was used

  16. Laparoscopic Management of a Proximal Jejunal Gallstone Ileus with Patulous Ampulla and Choledochal Cyst-a Report of Unusual Presentation and a Review.

    Science.gov (United States)

    Narkhede, Rajvilas Anil; Bada, Vijaykumar C; Kona, Lakshmi Kumari

    2017-02-01

    Gallstone ileus is a diagnosis of rarity, and a proximal site of obstruction in a young patient is even rare. Of the three cases in our experience, we found two cases of gallstone ileus (GSI) with typical epidemiology and presentation, one had combination of multiple rare associations. We report such a case, suspected to have gallstone ileus on ultrasound and confirmed diagnosis on computed tomography. Presence of biliary-enteric fistula, old age, and obstructive features, as in typical cases, was a bigger asset for diagnosis, but it was difficult to entertain diagnosis of GSI in young girl in absence of a demonstrable biliary-enteric fistula, with uncommon association of choledochal cyst and sickle cell disease. A very surprising finding, dilated major papilla, could however explain the pathogenesis which has also been reported in the past. Although differential opinions regarding management exist, we decided to follow two-stage surgery as our institute protocol. A minimal access approach has been immensely helpful in accurate diagnosis, and expedative management with early recovery has been proven in the past studies which we agreed with our experience.

  17. Replacement Gastrostomy Tube Causing Acute Pancreatitis: Case Series with Review of Literature

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    Anish M Shah

    2012-01-01

    Full Text Available Context Percutaneous endoscopic gastrostomy (PEG feedings are generally considered safe with few serious complications. Acute pancreatitis is a rare complication associated with replacement percutaneous endoscopic gastrostomy tubes. Case report We report two cases of acute pancreatitis induced by migrated replacement percutaneous endoscopic gastrostomy tubes. Conclusions Migration of a balloon into the duodenum can result in external manipulation of the ampulla of Vater thereby disturbing the flow of pancreatic secretions leading to acute pancreatitis. Recognition of this complication is important and should be included as potential etiology of acute pancreatitis in patients receiving percutaneous endoscopic gastrostomy feedings. Periodic examination and documentation of the distance of the balloon from the skin should be performed to document the position of the tubes or any inadvertent migration of the tubes. The use of Foley catheters as permanent replacement tubes should be considered medically inappropriate.

  18. Transplante renal em paciente pediátrico com associação de Vater: relato de caso Transplante renal en paciente pediátrico con asociación de Vater: relato de caso Renal transplantation in Vater association patient: case report

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    Antonio Paulo Nogueira Costa

    2003-06-01

    : La asociación de Vater es una ocurrencia extremamente rara y compleja y el presente relato se prende a la realización, por la primera vez, de transplante renal con donador cadáver en niño portador de ese defecto congénito cuyo resultado fue enteramente satisfactorio.BACKGROUND AND OBJECTIVES: Vater association is a polytopic disorder including several malformations of which radial hypoplasia is the most common observed at birth. This report aimed at describing a case of Vater association in a child submitted to renal transplantation. CASE REPORT: Male patient, 11 years old, 23 kg, Hbs positive, submitted to esophagostomy at 30 hours of life. Since 7 years of age patient is submitted to hemodialysis, currently via atrial catheter for the lack of other access ways. Renal transplantation with cadaver donor was performed without intercurrences with adequate diuresis after vascular anastomoses. Right iliac fossa hematoma was drained in the first postoperative day. Patient was discharged 21 days after transplantation with normal renal function. CONCLUSIONS: Vater association is an extremely rare and complex event and this report aimed at describing for the first time a renal transplantation with cadaver donor in a child with this congenital defect, the result of which has been fully satisfactory.

  19. Hemosuccus Pancreaticus: An Uncommon Cause of Gastrointestinal Hemorrhage. A Case Report

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    Chattopadhyay TK

    2004-09-01

    Full Text Available CONTEXT: Pseudoaneurysms of peripancreatic arteries usually arise as a complication of acute and chronic pancreatitis. These pseudoaneurysms may either bleed intra abdominally following rupture or may erode into the adjacent hollow viscera and manifest as gastrointestinal bleeding. Pseudoaneurysms rarely communicate with the pancreatic duct and bleeding occurs from the ampulla of Vater in the form of hemosuccus pancreaticus. CASE REPORT: We report a patient with chronic pancreatitis who presented with hemosuccus pancreaticus. Contrast enhanced computerized tomography and angiography revealed bleeding from a left gastric artery pseudoaneurysm. Despite multiple attempts, embolization was unsuccessful due to arterial spasm. The patient was successfully managed at emergency surgery by excision of the pseudoaneurysm sac and ligation of the left gastric artery. CONCLUSION: Bleeding from visceral artery pseudoaneurysms rarely manifests itself as hemosuccus pancreaticus. Most cases can be managed by angio-embolization. However, in patients with recurrent bleeding or failed embolization, emergency surgery is required.

  20. Chronic Calcific Pancreatitis Presenting as an Isolated Left Perinephric Abscess: A Case Report and Review of the Literature

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    Ragesh Babu Thandassery

    2011-09-01

    Full Text Available Context Acute and chronic pancreatitis may present with pseudocysts in atypical locations. Activated pancreatic enzymes track along anatomic fascial planes causing digestion of the surrounding tissues and resulting in distant pseudocysts. Pseudocysts at atypical locations pose significant diagnostic as well as therapeutic challenges. Case report We report an unusual presentation of a pancreatic pseudocyst in a young male who presented with a left perinephric abscess. Percutaneous drainage was not successful in resolving the abscess and he was subsequently diagnosed as having chronic pancreatitis together with a left perinephric abscess. Needle knife sphincterotomy of the ampulla of Vater resulted in the gradual resolution of the abscess. Conclusion We report a rare presentation of chronic pancreatitis with a perinephric abscess and its non-surgical management. This case report indicates that any patient presenting with a perinephric abscess of unknown etiology not responding to conventional treatment modalities should be investigated for underlying pancreatitis.

  1. Massive upper gastrointestinal haemorrhage due to direct visceral erosion of splenic artery aneurysm.

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    Shahani R

    1994-10-01

    Full Text Available Six male patients (age group: 30-60 years with aneurysm of the splenic artery presented with massive upper gastrointestinal tract hemorrhage. Five patients presented with hematemesis and one with melena. Chronic pancreatitis was noted in all the patients, four of whom were chronic alcoholics. Endoscopy was not useful in diagnosis. Bleeding through the Ampulla of Vater was seen in the patient with melena. Angiography was diagnostic in all. Pancreatic resection including the aneurysm(2, and bipolar ligation with underrunning of the aneurysm (3 were the operative procedures. Distal pancreatectomy with pancreatogastrostomy was carried out in the patient with hemosuccus pancreaticus. If endoscopy is inconclusive, angiography and early intervention is recommended to reduce the high mortality associated with conservative management.

  2. Pancreatic and Gastric Heterotopia with Associated Submucosal Lipoma Presenting as a 7-cm Obstructive Tumor of the Ileum: Resection with Double Balloon Enteroscopy

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    Kun Jiang

    2015-07-01

    Full Text Available Pancreatic and gastric heterotopias are rare clinical entities which have been identified throughout the entire length of the gastrointestinal tract. Combined gastric and pancreatic heterotopias, although unusual, have been described in the duodenum and jejunum, and in other structures, including Meckel's diverticulum and the ampulla of Vater. We report a novel case of pancreatic and gastric heterotopia with an associated submucosal lipoma in a 38-year-old female with a recent history of rectal cancer and chronic crampy abdominal pain. On computed tomography, a 7-cm luminal polypoid mass extending into the distal ileum was discovered. The mass was successfully resected using retrograde double balloon enteroscopy. We believe this is the first report of all three histological entities co-existing in an obstructive ileal lesion in an adult. It highlights endoscopic resection trough double enteroscopy as a safe alternative to more invasive surgical approaches for this type of lesion.

  3. Primary combined carcinoid and adenocarcinoma of the ileum associated with transitional carcinoma of the bladder. Single case report Causa infrecuente de disfagia en el postoperatorio tardío de la cirugía de la hernia de hiato

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    I. D. Venizelos

    2007-03-01

    Full Text Available Composite neoplasms, carcinoid and adenocarcinoma have been reported to occur in several parts of the body, including the stomach, ampulla of Vater, large bowel, lung, and urinary bladder. Here we report a case of a 74-year-old male with a composite carcinoid-adenocarcinoma of the ileum associated with a transitional cell carcinoma of the bladder. The microscopical examination of the composite tumor showed an admixture of typical carcinoid tumor and moderately a differentiated adenocarcinoma. Immunohistochemically, the two components showed clear-cut differentiations. A review of the literature revealed that this is the first reported case of composite carcinoid-adenocarcinoma of the ileum associated with transitional cell carcinoma of the urinary bladder.Las neoplasias compuestas, el carcinoide y el adenocarcinoma se ha observado que aparecen en varias partes del organismo, como el estómago, la ampolla de Vater, el intestino grueso, el pulmón y la vejiga urinaria. Publicamos aquí el caso de un varón de 74 años con un tumor compuesto de tipo carcinoide-adenocarcinoma del íleon asociado a un carcinoma vesical de células transicionales. El examen macroscópico del tumor compuesto mostró una mezcla de tumor carcinoide típico y adenocarcinoma moderadamente diferenciado. Desde el punto de vista inmunohistoquímico, los dos componentes estaban claramente diferenciados. Una revisión de la bibliografía reveló que este es el primer caso que se publica de un tumor compuesto de tipo carcinoide-adenocarcinoma del íleon asociado a un carcinoma de células transicionales de la vejiga urinaria.

  4. Pancreas divisum and duodenal diverticula as two causes of acute or chronic pancreatitis that should not be overlooked: a case report

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    De Filippo Massimo

    2008-05-01

    Full Text Available Abstract Introduction Pancreas divisum is a congenital anatomical anomaly characterized by the lack of fusion of the ventral and dorsal parts of the pancreas during the eighth week of fetal development. This condition is found in 5% to 14% of the general population. In pancreas divisum, the increased incidence of acute and chronic pancreatitis is caused by inadequate drainage of secretions from the body, tail and part of the pancreatic head through an orifice that is too small. The incidence of diverticula in the second part of the duodenum is found in approximately 20% of the population. Compression of the duodenal diverticula at the end of the common bile duct leads to the formation of biliary lithiasis (a principal cause of acute pancreatitis, pain associated with biliary lithiasis owing to compression of the common bile duct (at times with jaundice, and compression of the last part of Wirsung's duct or the hepatopancreatic ampulla (ampulla of Vater that may lead to both acute and chronic pancreatitis. Case presentation We describe the radiological findings of the case of a 75-year-old man with recurrent acute pancreatitis due to a combination of pancreas divisum and duodenal diverticula. Conclusion Magnetic resonance cholangiopancreatography is advisable in patients with recurrent pancreatitis (both acute and chronic since it is the most appropriate noninvasive treatment for the study of the pancreatic system (and the eventual presence of pancreas divisum and the biliary systems (eventual presence of biliary microlithiasis. Moreover, it can lead to the diagnostic suspicion of duodenal diverticula, which can be confirmed through duodenography with X-ray or computed tomography scan with a radio-opaque contrast agent administered orally.

  5. Serum Hyperamylasemia as a prognostic indicator of acute viral hepatitis and cirrhosis of liver

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    N. Kaur

    2014-06-01

    Full Text Available Liver disease is a condition that causes liver inflammation or tissue damage and affects liver function. Liver functions tests are abnormal in various liver diseases such as hepatitis, cirrhosis and end stage liver disease. The study of pancreatic enzymes for prognostic purpose in evolving liver disease is gaining ground and act as prognostic indicator for liver diseases. Present study has been planned to assess the serum amylase status in 50 patients of acute viral hepatitis and 50 patients of cirrhosis of liver in comparison to 50 normal healthy control subjects. Levels of serum amylase were determined by CNP- G3 kinetic method. The serum levels of amylase were significantly raised (p<0.0001 in patients compared to control group and levels were observed to be constantly increased with increased severity of liver diseases. The probable cause of variation in serum amylase enzymes in acute viral hepatitis and cirrhosis of liver is its anatomical proximity and common egress system through Ampulla of vater into the duodenum.

  6. [Perforated duodenal diverticulum: report of a case].

    Science.gov (United States)

    Gulotta, G; Agosta, G; Romano, G

    2001-01-01

    After the colon, the duodenum is the most common site of diverticula. Duodenal diverticula can be divided into two types: intraluminal or extraluminal. The latter are more frequent, with a prevalence ranging from 0.6 to 27% in relation to the diagnostic methods utilized. Females are more often affected than males. About 70-75% of extraluminal duodenal diverticula are located in a circular area centred around the ampulla of Vater within a radius of 2-3 cm; these are defined as periampullary or juxtapapillary. Perforation is the rarest type of complication and can simulate different clinical conditions. CT plays a fundamental role in diagnosis also in relation to the different diverticular topography. Perforation is an indication for emergency surgery. The authors describe the clinical case of a duodenal diverticulum containing the outlet of the papilla, complicated by perforation; CT showed retroduodenal fluid and free air. Emergency surgery with an external biliary drainage, naso-biliary probe, and a diverticulo-jejunostomy on a Roux-en-Y defunctionalised loop, resolved the condition.

  7. Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy: A review of the literature and critical reappraisal of the implicated pathomechanism

    Institute of Scientific and Technical Information of China (English)

    Kosmas I Paraskevas; Costas Avgerinos; Costas Manes; Dimitris Lytras; Christos Dervenis

    2006-01-01

    Pylorus-preserving pancreaticoduodenectomy (PPPD)is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head,neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE)comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the efficacy of a recently reported (but not yet tested in largescale studies) modification, that is, PPPD with antecolic duodenojejunostomy.(C) 2006 The WJG Press. All rights reserved.

  8. Biliary tract intraductal papillary mucinous neoplasm: A brief report and review of literature

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    Raveendran Subhash

    2014-01-01

    Full Text Available Biliary Tract Intraductal Papillary Mucinous Neoplasm (BT-IPMN is a very rare entity, gradually emerging into attention as sporadic cases are being reported worldwide. In this brief report we discuss about such an entity from our part of the world, based on a case from our institution. A 47-year-old female was referred to our department with jaundice, intermittent fever with chills and rigor of 6 weeks duration. Initial evaluation revealed obstructive jaundice with distended gall bladder. Imaging with ultrasonogram (USG and magnetic resonance imaging (MRI showed hugely dilated intra and extrahepatic biliary radicles with multiple and diffuse soft tissue lesions filling the common bile duct (CBD extending to the ductal system of left lobe of liver. A side viewing endoscopy demonstrated mucin extruding from a prominent ampulla of Vater. The patient was managed successfully by left hepatectomy with pancreaticoduodenectomy (HPD. Gross pathological examination of the specimen showed marked dilatation of intra and extra hepatic bile ducts with multiple polypoidal lesions and plenty of mucin filling the entire biliary ductal system. Histopathology revealed predominantly intraductal papillary mucinous adenocarcinoma at the hilum extending to left bile duct with diffuse dysplastic changes throughout the biliary tree. Thus the clinical, radiological and pathological features of this lesion clearly fit into the diagnosis of BT-IPMN, which is slowly being established as a definite clinical entity with features much similar to its pancreatic counterpart.

  9. Cholangiocarcinoma: A position paper by the Italian Society of Gastroenterology (SIGE), the Italian Association of Hospital Gastroenterology (AIGO), the Italian Association of Medical Oncology (AIOM) and the Italian Association of Oncological Radiotherapy (AIRO).

    Science.gov (United States)

    Alvaro, Domenico; Cannizzaro, Renato; Labianca, Roberto; Valvo, Francesca; Farinati, Fabio

    2010-12-01

    The incidence of Cholangiocellular carcinoma (CCA) is increasing, due to a sharp increase of the intra-hepatic form. Evidence-ascertained risk factors for CCA are primary sclerosing cholangitis, Opistorchis viverrini infection, Caroli disease, congenital choledocal cist, Vater ampulla adenoma, bile duct adenoma and intra-hepatic lithiasis. Obesity, diabetes, smoking, abnormal biliary-pancreatic junction, bilio-enteric surgery, and viral cirrhosis are emerging risk factors, but their role still needs to be validated. Patients with primary sclerosing cholangitis should undergo surveillance, even though a survival benefit has not been clearly demonstrated. CCA is most often diagnosed in an advanced stage, when therapeutic options are limited to palliation. Diagnosis of the tumor is often difficult and multiple imaging techniques should be used, particularly for staging. Surgery is the standard of care for resectable CCA, whilst liver transplantation should be considered only in experimental settings. Metal stenting is the standard of care in inoperable patients with an expected survival >4 months. Gemcitabine or platinum analogues are recommended in advanced CCA whilst there are no validated neo-adjuvant treatments or second-line chemotherapies. Even though promising results have been obtained in CCA with radiotherapy, further randomized controlled trials are needed.

  10. Emergency Pancreatoduodenectomy with Preservation of Gastroduodenal Artery for Massive Gastrointestinal Bleeding due to Duodenal Metastasis by Clear Cell Renal Cell Carcinoma in a Patient with Celiac Artery Stenosis

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    Kyriakos Neofytou

    2014-01-01

    Full Text Available Duodenal metastasis from renal cell carcinoma is rare, and even rarer is a massive gastrointestinal bleeding from such tumours. Coeliac occlusive disease, although rarely symptomatic, can lead to ischaemic changes with anastomotic dehiscence and leaks when a patient undergoes pancreatoduodenectomy. A 41-year-old man with known metastasis to the adrenal glands and the second part of the duodenum close to the ampulla of Vater from clear cell renal cell carcinoma was admitted to our department due to massive gastrointestinal bleeding from the duodenal metastasis. Endoscopic control of the bleed was not possible, while the bleeding vessel embolization was able to control the haemorrhage only temporarily. An angiography during the embolization demonstrated the presence of stenosis of the coeliac artery and also hypertrophic inferior pancreaticoduodenal arteries supplying the proper hepatic artery via the gastroduodenal artery (GDA. The patient underwent emergency pancreatoduodenectomy with preservation of the gastroduodenal artery. The patient had an uneventful recovery and did not experience further bleeding. Also the blood flow to the liver was compromised as shown by the normal liver function tests (LFTs postoperatively. To the best of our knowledge, this is the first report of a preservation of the GDA during an emergency pancreatoduodenectomy.

  11. US-guided percutaneous transhepatic biliary drainage: comparative study of right-sided and left-sided approach

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Hwan; Cha, Soon Joo [College of Medicine, Inje Univ., Kimhae (Korea, Republic of)

    2002-02-01

    To compare the feasibility and safety of US-guided right and left percutaneous transhepatic biliary drainage (PTBD). Between March 1998 and May 1999, 32 patients underwent 36 US-guided right or left PTBD in referred order, alternatively. The causes of biliary obstruction were bile duct stone (n=2), bile duct carcinoma (n=10), carcinoma of the pancreas (n=9), GB carcinoma (n=7), metastasis to the porta hepatis (n=3), and carcinoma of the ampulla of vater (n=1). Technical success, procedure time, fluoroscopic time, and complications were evaluated. PTBD was successful in 94% of both right and left approach. The average procedure time was 9.7 {+-}3.8 min. in the right approach and 9.6 {+-}3.1 min. in the left approach, respectively (p=0.794). The average fluoroscopic time were 3.9{+-}2.4 min. in the right approach and 3.8{+-}2.2 min. in the left approach (p=0.892). A major complication, bile peritonitis, occurred in one of 16 patient with right-sided approach. Minor complications occurred in six right (2 hemobilia, 3 tube malfunction, 1 cholangitis) and three left (1 hemobilia, 1 fever, 1cholangitis) PTBD. There were no significant difference in the complication rates between right and left PTBD (p=0.729). There were no significant differences in feasibility and safety in US-guided right and left PTBD.

  12. A STUDY OF OBSTRUCTIVE JAUNDICE WITH FOCUS ON PREDICTIVE FACTORS FOR OUTCOME

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    Srinidhi

    2014-07-01

    Full Text Available BACKGROUND AND OBJECTIVES: Obstructive jaundice is a problem frequently encountered by general surgeons. A clear understanding of the etiology, presentation and management is a prerequisite for the management of obstructive jaundice. There is a need to identify the risk factors which may predict outcome. Hence, a detailed study of the various causes of obstructive jaundice and their management is of paramount importance. METHODS: A Prospective observational study was undertaken to investigate the pattern of clinical presentation, diagnosis and management of the different causes of obstructive jaundice. About 21 consecutive patients with symptoms and signs of obstructive jaundice were included in the study. Cases were admitted, examined, investigated and operated during the period of Nov 2010 to Aug 2012. RESULTS & CONCLUSION: The highest age incidence of obstructive jaundice was in the 50 - 80 years with maximum incidence in the 6th decade. There was an increased incidence in female i.e. M: F=1:2.5. Most common cause of obstructive jaundice is choledocholithiasis, followed by periampullary carcinoma. Among periampullary carcinoma, Ca head of pancreas and Ca Ampulla of Vater are the common causes. Jaundice is the most common presentation of surgical jaundice followed by pain abdomen, nausea/vomiting, itching, loss of weight and fever. Ultrasonography was the investigation of choice in our hospital. It is cheap, safe and reliable. Early diagnosis and management helps to reduce the mortality and morbidity rate. ERCP is comparatively as good as Open exploration of CBD and Choledochoduodenostomy for CBD calculi. Good survival benefit in cases of malignant obstructive jaundice depends on detecting the disease early in its course. It was noted on statistical analysis of malignant cases that the values of direct bilirubin levels were significantly higher in those patients who expired postoperatively compared to surviving patients. Hence these parameters

  13. Expression of Bcl-2 and Bax in extrahepatic biliary tract carcinoma and dysplasia

    Institute of Scientific and Technical Information of China (English)

    Sheng-Mian Li; Shu-Kun Yao; Nobuyoshi Yamamura; Toshitsugu Nakamura

    2003-01-01

    AIM: To compare the difference of expression of Bcl-2 and Bax in extrahepatic biliary tract carcinoma and dysplasia, and to analyze the role of Bcl-2 and Bax proteins in the progression from dysplasia to carcinoma and to evaluate the correlation of Bcl-2/Bax protein expression with the biological behaviors.METHODS: Expressions of Bcl-2 and Bax were examined immunohistochemically in 27 cases of extrahepatic biliary tract carcinomas (bile duct carcinoma: n=21, carcinoma of ampulla of Vater: n=6), and 10 cases of atypical dysplasia.Five cases of normal biliary epithelial tissues were used as controls. A semiquantitative scoring system was used to assess the Bcl-2 and Bax reactivity.RESULTS: The expression of Bd-2 was observed in 10 out of 27 (37.0 %) invasive carcinomas, 1 out of 10 clysplasias, none out of 5 normal epithelial tissues. Bax expression rate was 74.1% (20/27) in invasive carcinoma, 30 % (3/10) in dysplasia,and 40 % (2/5) in normal biliary epithelium. Bcl-2 and Bax activities were more intense in carcinoma than in dysplasia,with no significant difference in Bcl-2 expression (P=0.1:10),and significant difference in Bax expression (P=0.038). Level of Bax expression was higher in invasive carcinoma than in dysplasia and normal tissue (P=0.012). Bcl-2 expression was correlated to Bax expression (P=0.0059). However, Bcl-2/Bax expression had no correlation with histological subtype,grade of differentiation, or level of invasion.CONCLUSION: Increased Bcl-2/Bax expression from dysplasia to invasive tumors supports the view that this is the usual route for the development of extrahepatic biliary tract carcinoma. Bcl-2/Bax may be involved, at least in part,in the apoptotic activity in extrahepatic biliary carcinoma.

  14. 饮水低张MSCT技术在胆管梗阻性疾病中的应用%Diagnosis of biliary tract obstructive diseases by multislice CT after low tension and drinking water

    Institute of Scientific and Technical Information of China (English)

    高飞; 程涛; 韦炜

    2012-01-01

    Objective To explore the value of the multi-slice CT(MSCT) after low tension and drinking water in the diagnosis of biliary tract obstructive diseases. Methods Seventy six patients planning to be diagnosed as obstructive jaundice clinically were examined by multi-slice CT after low tension and drinking water, and their pathologic results were analyzed and compared. Results The third period of bile duct was positioned with the highest accuracy; bile duct stones were found with the highest qualitative accuracy in benign biliary obstruction; vater ampulla carcinoma and extrahepatic bile duct carcinoma were found with the higher qualitative accuracy in malignant biliary obstruction; there was "progressive expansion" in 24 cases, 17 cases of which were benign lesion and 7 cases of which were malignant lesion; there was "segmental expansion" in 12 cases, 7 cases of which were benign lesion and 5 cases of which were malignant lesion; there was "soft rattan" in 38 cases, 1 case of which was benign lesion and 37cases of which were malignant lesion; there were 25 cases of "edge sample" narrow and 16 cases of " beak kind" narrow, which were malignant lesion; 7 cases of "target sign" were choledocholithiasis; there were 25 cases of vater ampulla carci- nom,7 cases of which had "half levy", 8 cases of which had "double loop levy", 12 cases of which had "double duct", and 12 cases of which had "finger sign". Conclusion By means of multi-slice CT after low tension and drinking water,there were some characteristics in benign and malignant biliary tract obstructive diseases in CT performance, and thus MSCT positioning accuracy and qualitative accuracy can be improved by combining the various signs.%目的 探讨饮水低张MSCT技术在胆管梗阻疾病中的应用价值.方法对76例临床拟诊梗阻性黄疸患者行饮水低张MSCT扫描,分析其CT表现,与病理结果对照.结果定位准确率最高的为第3段胆管;良性胆道病变定性准确率最高的是胆管

  15. Spiral CT features of abdomen after whipple's operation

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    Kim, T. H.; Lee, K. Y.; Shin, K. H.; Jung, M. H.; Park, C. M.; Cha, I. H. [Korea Univ. College of Medicine, Seoul (Korea, Republic of)

    1997-04-01

    To assess the CT features of postoperative anatomical changes, surgical complications, and patterns of tumor recurrence after Whipple's operation. 42 spiral CT scans of 31 patients who had undergone Whipple's operation were retrospectively reviewed. Postoperative diagnoses were distal CBD cancer in 13 patients, cancer of the ampulla of Vater in ten, cancer of the head of the pancreas in seven, and microcystic cystadenocarcinoma of the pancreas in one. Time intervals between surgery and CT ranged from 1 week to 5 years. CT features of postoperative anastomotic changes, surgical complications, and patterns of tumor recurrence were analyzed. Gastro- or duodeno-jejunal anastomosis was seen in 32 CT scans(74%), pancreaticojejunostomy in 27(64%), and choledochojejunostomy in 24(57%). Pneumobilia was seen in ten patients(34%). Abnormal fluid collections in the peripancreatic and perihepatic space were demonstrated in two patients who underwent CT scans within 3 weeks after operation. Other complications included wound abscess(n=2), and portal vein occlusion(n=1). The most common site of metastasis was the lymph node(n=8)(retroperitoneal:n=5; mesentery root:n=4; and celiac:n=2), followed by the liver(n=6), peritoneum(n=3), adrenal gland(n=2), and afferent loop(n=1). In three cases, there was local recurrence in the pancreatic bed. To reduce possible diagnostic errors during CT interpretation, a Knowledge of normal postoperative anatomy, common complications, and patterns of disease recurrence following Whipple's operation is important.

  16. A case report of an ampullary tumor presenting with spontaneous perforation of an aberrant bile duct and treated with total laparoscopic pancreaticoduodenectomy

    Directory of Open Access Journals (Sweden)

    Kaplan Mehmet

    2012-07-01

    Full Text Available Abstract Background This case report discusses a patient who presented with bile peritonitis due to spontaneous perforation of an aberrant bile duct that originated in the triangular ligament of the liver. It was associated with an ampullary tumor and treated with total laparoscopic pancreaticoduodenectomy (TLPD. Case report A 58-year-old male patient was admitted to the emergency department of Medical Park Gaziantep Hospital in September 2009 with acute abdominal findings. He underwent an urgent laparoscopy, and, interestingly, bile peritonitis due to the rupture of an aberrant bile duct in the triangular ligament was noted. After laparoscopic treatment of the acute conditions, the follow-up examinations of the patient showed the finding of obstructive jaundice. Endoscopic retrograde cholangio-pancreatography revealed a 1-cm polypoid mass located at the ampulla of Vater (duodenal papilla with possible extension to the ampullary sphincter. A stent was inserted for temporary biliary drainage, and subsequent endoscopic biopsy showed the pathological finding of adenocarcinoma. After waiting for a 1-month period for the peritonitis to heal, the patient underwent pylorus-preserving TLPD and was discharged without any major complications on postoperative day 7. Conclusion In patients with bile peritonitis, it should be considered that the localization of the perforation may be in an aberrant bile duct localized at the triangular ligament and the etiology may be associated with an obstructing periampullary tumor. Laparoscopic pancreaticoduodenectomy is a feasible operative procedure in carefully selected patients. This technique can achieve adequate margins and follows oncological principles. Randomized comparative studies are needed to establish the superiority of minimally invasive surgery over traditional open surgery.

  17. Bone and brain metastases from ampullary adenocarcinoma

    Institute of Scientific and Technical Information of China (English)

    Ioannis A Voutsadakis; Stergios Doumas; Konstantinos Tsapakidis; Maria Papagianni; Christos N Papandreou

    2009-01-01

    Ampullary carcinoma is the second most common cancer of the peri-ampullary area after pancreatic carcinoma and metastasizes mostly intra-abdominally and to the liver. Extra-abdominal metastases are less frequent. In this report we describe the case of a patient with resected adenocarcinoma of the ampulla of Vater who developed skeletal metastases in the lower extremity and brain metastases. We briefly discuss aspects of this comparatively rare gastrointestinal malignancy.

  18. Ascariasis cholecystitis: An unusual cause

    Directory of Open Access Journals (Sweden)

    Shetty Balakrishna

    2008-01-01

    Full Text Available Ascariasis is the most common helminthic infection to infest man. Usually the adult worm lives in the small intestine. Rarely it migrates through the ampulla of vater and enters the common bile duct. We are reporting a case of gall bladder ascariasis causing acute cholecystitis treated by laparoscopic cholecystectomy. Presence of Ascaris lumbricoides in gallbladder is rare entity as it is difficult to reach there due to the narrow and tortuous cystic duct.

  19. Changes of endolymphatic pressure in the semicircular canal of pigeon by caloric stimulation

    Science.gov (United States)

    Wada, Y.; Suzuki, H.; Watanabe, S.

    1994-08-01

    It gets into difficult to explain the mechanism of caloric nystagmus only by convection theory from results of microgravity experiments. One of the other theories is an occurrence of a relative volume change due to a temperature change. Since the volume change must lead to a pressure change after caloric stimulation, we tried to measure the ampulla pressure of the horizontal semicircular canal in pigeons (Columba livia) using an improved servo micropipette system. The main result was that the ampulla pressure increased by cooling and decreased by heating. The changes of the ampulla pressure depended on the temperature change but were not influenced by the pigeon's head position.

  20. SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.

    Science.gov (United States)

    Agaimy, Abbas; Daum, Ondrej; Märkl, Bruno; Lichtmannegger, Ines; Michal, Michal; Hartmann, Arndt

    2016-04-01

    Undifferentiated gastrointestinal tract carcinomas are rare highly aggressive neoplasms with frequent but not obligatory rhabdoid features. Recent studies showed loss of SMARCB1 (INI1), a core subunit of the SWI/SNF chromatin remodeling complex, in 50% of tested cases. However, the molecular pathways underlying histologically similar but SMARCB1-intact cases are unknown. We herein analyzed 13 cases for expression of 4 SWI/SNF complex subunits SMARCB1, SMARCA2, SMARCA4, and ARID1A and the mismatch-repair proteins MLH1, MSH2, MSH6, and PMS2 by immunohistochemistry. Patients included 12 men and 1 woman aged 32 to 81 years (median, 57 y). Site of origin was colon (5), small bowel (2), stomach (3), small+large intestine (1), small intestine+ampulla of Vater (1), and esophagogastric junction (1). All tumors showed anaplastic large to medium-sized cells with variable rhabdoid features, pleomorphic giant cells, and, rarely, spindle cell foci. Abortive gland formation was seen in 3 cases and bona fide glandular component in 1 case. Most cases strongly expressed vimentin and variably pancytokeratin. In total, 12/13 cases (92%) showed loss of at least 1 SWI/SNF component. Loss of SMARCB1 (5/13), SMARCA2 (10/13), SMARCA4 (2/13), and ARID1A (2/13) was observed either in combination or isolated. SMARCA2 loss was isolated in 5 cases and coexisted with lost SMARCB1 in 5 cases (all 5 SMARCB1-deficient tumors showed loss of SMARCA2 as well). Co-inactivation of SMARCB1 and SMARCA4 or of SMARCA2 and SMARCA4 was not observed. Two mismatch-repair-deficient cases (MLH1/PMS2) showed concurrent loss of SMARCB1, SMARCA2, and (one of them) ARID1A. This study illustrates for the first time loss of different components of the SWI/SNF complex other than SMARCB1 in undifferentiated gastrointestinal carcinomas including novel SMARCA4-deficient and SMARCA2-deficient cases. Our results underline the close link between SWI/SNF deficiency and the aggressive rhabdoid phenotype. Frequent loss of SMARCA

  1. A new method of preventing bile duct injury in laparoscopic cholecystectomy

    Institute of Scientific and Technical Information of China (English)

    Fang Xu; Cheng-Gang Xu; De-Zheng Xu

    2004-01-01

    AIM: Of all the complications of laparoscopic cholectecystomy,bile duct injury (BDI) is the most serious complication.The prevention of injury to the common bile duct (CBD) remains a significant concern in laparoscopic cholecystectomy (LC).Different kinds of methods have been advanced to avoid this injury but no single method has gained wide acceptance.Because of various limitations of current methodologies we began a study using cold light illumination of the extrahepatic biliary system (light cholangiography LCP) to better visualize this area and thereby reduce the risk of bile duct injury.METHODS: Thirty-six patients with cholelithiasis were divided into two groups.Group Ⅰ (16 cases) received LCP and group Ⅱ (20 cases) received methelenum coeruleum cholangiography (MCCP).In group Ⅰ cold light was used to illuminate the common bile duct by leading an optical fiber into the common duct with a duodenoscope at the time of LC.The light coming from the fiber in the CBD could clearly illuminate the location of CBD and hepatic duct establishing its location relative to the cystic duct.This method was compared with the dye injection technique using methelenum coeruleum.RESULTS: In group Ⅰ thirteen cases were successfully illuminated and three failed.The cause of three failed cases was due to the difficulty in inserting the fiber into the ampulla of Vater.No complications occurred in the thirteen successful cases.In each of these successful cases the location of the common and hepatic ducts was clearly seen differentiating the ductal system from surrounding anatomy.In ten cases both the left and right hepatic ducts could be seen and in three only the right hepatic ducts were seen.In four of the thirteen cases,cystic ducts were also seen.In group Ⅱ,eighteen of the twenty cases were successful.The location of extrahepatic ducts became blue differentiating the ductal system from surrounding anatomy.Two cases failed due to a stone obstructing the cystic duct

  2. Cancers of the pancreas and biliary tract: epidemiological considerations.

    Science.gov (United States)

    Fraumeni, J F

    1975-11-01

    often with other risk factors. In some respects, bile duct and pancreatic tumors are alike. The male predominance of both tumors, an association between cholecystectomy and pancreatic cancer, and other considerations have prompted the notion that the same biliary carcinogens may affect the bile duct, ampulla of Vater, or, by reflux, the pancreatic duct. Various epidemiological and interdisciplinary approaches are needed to further clarify the origins of biliary tract and pancreatic cancers, but nutritional studies hold special promise in laying the groundwork for prevention of these tumors.

  3. Anomalous opening of the common bile duct into the duodenal bulb: endoscopic treatment

    Directory of Open Access Journals (Sweden)

    Oguz Dilek

    2007-07-01

    Full Text Available Abstract Background Anomalous biliary opening especially the presence of the ampulla of Vater in the duodenal bulb is a very rare phenomenon. We report clinical implications, laboratory and ERCP findings and also therapeutic approaches in 53 cases. Methods The data were collected from the records of 12.158 ERCP. The diagnosis was established as an anomalous opening of the common bile duct (CBD into the duodenal bulb when there is an orifice observed in the bulb with the absence of a papillary structure at its normal localization and when the CBD is visualized by cholangiography through this orifice without evidence of any other opening. Results A total of 53 cases were recruited. There was an obvious male preponderance (M/F: 49/4. Demographic data and ERCP findings were available for all, but clinical characteristics and laboratory findings could be obtained from 39 patients with full records. Thirty – seven of 39 cases had abdominal pain (95% and 23 of them (59% had cholangitis as well. Elevated AP and GGT were found in 97.4% (52/53. History of cholecystectomy was present in 64% of the cases, recurrent cholangitis in 26% and duodenal ulcer in 45%. Normal papilla was not observed in any of the patients and a cleft-like opening was evident instead. The CBD was hook shaped at the distal part that opens to the duodenal bulb. Pancreatic duct (PD was opening separately into the bulb in all the cases when it was possible to visualize. Dilated CBD in ERCP was evident in 94% and the CBD stone was demonstrated in 51%. PD was dilated in four of 12 (33% cases. None of them has a history of pancreatitis. Endoscopically, Papillary Balloon Dilatation instead of Sphincterotomy carried out in 19 of 27 patients (70% with choledocholithiazis. Remaining eight patients had undergone surgery (30%. Clinical symptoms were resolved with medical treatment in 16(32% patients with dilated CBD but no stone. Perforation and bleeding were occurred only in two patients

  4. Robot-assisted pancreatoduodenectomy with preservation of the vascular supply for autologous islet cell isolation and transplantation: a case report

    Directory of Open Access Journals (Sweden)

    Giulianotti Piero

    2012-03-01

    Full Text Available Abstract Introduction For patients with chronic pancreatitis presenting with medically intractable abdominal pain, surgical intervention may be the only treatment option. However, extensive pancreatic resections are typically performed open and are associated with a substantial amount of postoperative pain, wound complications and long recovery time. Minimally invasive surgery offers an avenue to improve results; however, current limitations of laparoscopic surgery render its application in the setting of chronic pancreatitis technically demanding. Additionally, pancreatic resections are associated with a high incidence of diabetes. Transplantation of islets isolated from the resected pancreas portion offers a way to prevent post-surgical diabetes; however, preservation of the vascular supply during pancreatic resection, which determines islet cell viability, is technically difficult using current laparoscopic approaches. With recent advances in the surgical field, robotic surgery now provides a means to overcome these obstacles to achieve the end goals of pain relief and preserved endocrine function. We present the first report of a novel, minimally invasive robotic approach for resection of the pancreatic head that preserves vascular supply and enables the isolation of a high yield of viable islets for transplantation. Case presentation A 35-year old Caucasian woman presented with intractable chronic abdominal pain secondary to chronic pancreatitis, with a stricture of her main pancreatic duct at the level of the ampulla of Vater and distal dilatation. She was offered a robotic-assisted pylorus-preserving pancreatoduodenectomy and subsequent islet transplantation, to both provide pain relief and preserve insulin-secretory reserves. Conclusion We present a novel, minimally invasive robotic approach for resection of the pancreatic head with complete preservation of the vascular supply, minimal warm ischemia time (less than three minutes and

  5. Diet and biliary tract cancer risk in Shanghai, China

    Science.gov (United States)

    Nelson, Shakira M.; Gao, Yu-Tang; Nogueira, Leticia M.; Shen, Ming-Chang; Wang, Bingsheng; Rashid, Asif; Hsing, Ann W.; Koshiol, Jill

    2017-01-01

    Trends in biliary tract cancer incidence rates have increased in Shanghai, China. These trends have coincided with economic and developmental growth, as well as a shift in dietary patterns to a more Westernized diet. To examine the effect of dietary changes on incident disease, we evaluated associations between diet and biliary tract cancers amongst men and women from a population-based case-control study in Shanghai, China. Biliary tract cancer cases were recruited from 42 collaborating hospitals in urban Shanghai, and population-based controls were randomly selected from the Shanghai Household Registry. Food frequency questionnaire data were available for 225 gallbladder, 190 extrahepatic bile duct, and 68 ampulla of Vater cancer cases. A total of 39 food groups were created and examined for associations with biliary tract cancer. Interestingly, only four food groups demonstrated a suggested association with gallbladder, extrahepatic bile duct, or ampulla of Vater cancers. The allium food group, consisting of onions, garlic, and shallots showed an inverse association with gallbladder cancer (OR: 0.81, 95% CI: 0.68–0.97). Similar trends were seen in the food group containing seaweed and kelp (OR: 0.79, 95% CI: 0.67–0.96). In contrast, both preserved vegetables and salted meats food groups showed positive associations with gallbladder cancer (OR:1.27, 95% CI: 1.06–1.52; OR: 1.18, 95% CI: 1.02–1.37, respectively). Each of these four food groups showed similar trends for extrahepatic bile duct and ampulla of Vater cancers. The results of our analysis suggest intake of foods with greater anti-inflammatory properties may play a role in decreasing the risk of biliary tract cancers. Future studies should be done to better understand effects of cultural changes on diet, and to further examine the impact diet and inflammation have on biliary tract cancer incidence. PMID:28288186

  6. Vater einer großen Nachkommenschaft von Forschungsreisenden ...“ Ehrungen Alexander von Humboldts im Jahre 1869

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    Ilse Jahn

    2004-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn 1869 the “Naturwissenschaftlicher Verein” was founded in Magdeburg (Saxony Anhalt. That was the time when the scientific world celebrated Alexander von Humboldt’s 100th birthday. In this context, Humboldt’s achievements were remembered during the founding ceremony of that society. The paper which was read in September 2003 on a meeting of this organisation, focuses on three famous naturalists who celebrated Humboldt because they owed him much help in their own professional careers. The botanist Matthias Jacob Schleiden gave a memorial speech in 1869 in Dresden. The physiologist and pioneer of electro-biology Emil du Bois-Reymond honoured his mentor A. v. Humboldt on the occasion of the dedication of the statues of Wilhelm and Alexander in 1883 in Berlin. Charles Darwin expressed his gratitude to Humboldt by sending him in 1839 the report of his travels and received an interesting reply. These three scholars represented a new epoch in the development of the natural sciences. The paper includes a recently re-discovered letter from Humboldt to Schleiden, dated April 13, 1842.

  7. Recurrent abdominal complaints caused by a cecal neurofibroma: A case report

    Institute of Scientific and Technical Information of China (English)

    Willem Donk; Paul Poyck; Pieter Westenend; Wilco Lesterhuis; Fried Hesp

    2011-01-01

    Gastrointestinal involvement of neurofibromatosis type 1 (NF1, Von Recklinghausen's disease) is generally associated with the upper gastrointestinal tract. Abdominal manifestation of NF1 includes several tumors such as malignant peripheral nerve sheath tumors, gastrointestinal stromal tumors and ampulla of vater tumors. However, colonic involvement in NF1 patients is rare. We report a case of a patient presenting with dysphagia, weight loss, intermittent abdominal pain and constipation caused by a single cecal neurofibroma obstructing the ileocecal valve. Also gastrointestinal involvement of the lower tract should be considered in patients with NF1 presenting with abdominal complaints.

  8. A case of dextrocardia, radial ray malformation and renal anomaly.

    Science.gov (United States)

    Nallegowda, M; Singh, U; Shivananda; Shukla, R; Kabra, M

    2003-10-01

    A 12-year-old boy is described with bilateral radial club hands, scoliosis, hypospadias, isolated dextrocardia, hypoplastic ribs, an ectopic kidney and spina bifida occulta. Although some of the clinical features of this patient are seen in VATER association and sacrococcygeal dysgenesis, the presence of dextrocardia, facial dysmorphism, radial, renal and vertebral anomalies preclude these diagnoses.

  9. The illusion of severe carpal tunnel syndrome (CTS).

    Science.gov (United States)

    Gutmann, Ludwig; Nance, Christopher

    2010-02-01

    Thenar atrophy occurs in patients with severe carpal tunnel syndrome (CTS) of long-standing duration. In this report we present a young woman with mild bilateral CTS, based on electrophysiological studies, in whom marked thenar atrophy was on a congenital basis related to the VATER association (vertebral anomalies, anal atresia, tracheoesophageal fistula, and radial or renal abnormalities).

  10. [Prospects of intraoperative dynamic cholangio-manometry by tensor detectors with graphic recording of pressure function].

    Science.gov (United States)

    Tsatsanidi, K N; Pugaev, A V; Gordeev, P S; Sandrikov, V A; Mukha, A V; Gambarian, A R

    1991-02-01

    Intraoperative cholangio-manometry with a miniature tensor sensor and graphic recording of the results were conducted to study the function of the major duodenal papilla in 53 patients. A periodical activity of the ampulla of the papilla was revealed, which was characterized by certain values of the peak and basal pressure, and duration of contraction and relaxation periods. The numerical values and the pattern of the pressure curve differed in patients with obstructive cholecystitis, biliary pancreatitis, and a concrement incarcerated in the ampulla of the papilla. The informativeness of the study increases with the use of the glucagon test.

  11. Excitatory and inhibitory synaptic mechanisms at the first stage of integration in the electroreception system of the shark

    DEFF Research Database (Denmark)

    Rotem, Naama; Sestieri, Emanuel; Hounsgaard, Jørn Dybkjær;

    2014-01-01

    , the afferent nerve originating from the ampullae of Lorenzini targets specific neurons located at the Dorsal Octavolateral Nucleus (DON), the first stage of integration in the electroreception system. Using intracellular recordings in an isolated brainstem preparation from the shark we analyze the properties...

  12. Anatomical basis of a passive mechanism for ovum retention at the ampulloisthmic junction.

    Science.gov (United States)

    Halbert, S A; Szal, S E; Broderson, S H

    1988-08-01

    The unexplained behavior of egg retention at the ampulloisthmic junction (AIJ) is a mechanical phenomenon; therefore the key to this process must lie in the anatomy of the oviduct. To investigate the concept that simple anatomical differences between ampulla and isthmus cause AIJ retention, we quantified, in these two regions of the rabbit oviduct, the structural characteristics of the tubal wall that show marked differences: wall thickness and luminal caliber. The oviductal wall greatly increases in thickness and decreases in luminal caliber abruptly at the transition from ampulla to isthmus. These passive mechanical factors predict a dramatically reduced distensibility of the isthmic wall compared to that of the ampulla, and these factors provide us with a simple model to account for the apparent sphincteric activity of the AIJ. Actual measurements of tubal distensibility confirmed our prediction. In addition, egg transport studies following microsurgical removal of the AIJ showed normal transport, an indication that no special structure need exist at the AIJ. We conclude that the contrasting morphology of the ampulla and isthmus may suffice to explain AIJ retention, and no special active mechanism need be postulated.

  13. Identification of new cancer biomarkers based on aberrant mucin glycoforms by in situ proximity ligation

    DEFF Research Database (Denmark)

    Pinto, Rita; Carvalho, Ana S; Conze, Tim

    2012-01-01

    ) based on existing monoclonal antibodies directed to MUC1, MUC2, MUC5AC and MUC6 mucins and to cancer-associated carbohydrate antigens Tn, Sialyl-Tn (STn), T, Sialyl-Le(a) (SLe(a) ) and Sialyl-Le(x) (SLe(x) ) we screened a series of 28 mucinous adenocarcinomas from different locations (stomach, ampulla...

  14. HYDRODYNAMIC BEHAVIOR OF AN UNDERWATER MOVING BODY AFTER WATER ENTRY

    Institute of Scientific and Technical Information of China (English)

    施红辉; 高见卓也

    2001-01-01

    An experimental study was conducted to investigate the vater entry phenomenon. A facility was designed to carry out the tests with the entry velocities of around 352 m/s. Visualization, pressure measurement, velocity measurement and underwater impact test were performed to investigate the hydroballistic behavior of the underwater moving body, the underwater flow field, the supercavitation,etc.. This study shows that the motion of a high-speed underwater body is strongly three-dimensional and chaotic. Furthermore, it is found that the distribution of the trajectory deflection of the underwater projectile depends on the depth of water. It is also found by measuring the deformation on a witness plate submerged in water,that the impact energy of an underwater projectile is reduced as it penetrates deeper into vater.

  15. Altered cupular mechanics: a cause of peripheral vestibular disorders?

    Science.gov (United States)

    Helling, Kai; Watanabe, Nobuhiro; Jijiwa, Hiroyasu; Mizuno, Yoshio; Watanabe, Satoru; Scherer, Hans

    2002-06-01

    It has taken many decades to arrive at today's concept of cupula mechanics in the stimulation of endolymphatic flows on the hair cells in the ampullae of the semicircular canal. While Steinhausen assumed free swing-door movement of the cupula in the 1930s, Hillman was the first to demonstrate firm cupula attachment to the ampulla wall as a physiological necessity in the 1970s. In contrast to the present clinical concepts of acute peripheral vestibular functional disorders (circulatory disturbances, viral or bacterial infection, altered electrolytes in the endolymph), this study examines the extent to which an impaired attachment mechanism can trigger peripheral vestibular disorders. For this purpose, we used a pigeon model (n = 8), in which mechanical detachment of the cupula from the ampulla wall was achieved by means of a targeted pressure increase in the ampulla of the lateral semicircular canal. In two additional animals the labyrinth was completely destroyed on one side in order to directly compare partial and complete vestibular disorders. In this way partial damage to the lateral semicircular canal ampulla presents a clinical picture whose symptoms are very similar to those of an idiopathic vestibular disorder in humans. Their intensity and course of compensation differ markedly from the symptoms of complete vestibular destruction. Subsequent histological examination revealed that the hair cells remained intact during the experimental detachment of the cupula. Our results thus show that only altered cupula mechanics seem to trigger the clinical picture of a peripheral vestibular disorder. This may result in completely new approaches to differential diagnosis and the therapy of vestibular neuronitis.

  16. ABO-incompatible living donor intestinal transplantation: report of one case%ABO血型不合亲属活体小肠移植一例报告

    Institute of Scientific and Technical Information of China (English)

    吴国生; 赵青川; 王为忠; 王勉; 施海; 陈冬利; 郑建勇; 赵正维; 李孟彬

    2014-01-01

    目的 总结1例ABO血型不合亲属活体小肠移植的治疗经验.方法 患者为女性,16岁,ABO血型为B型,因全部小肠和右半结肠坏死行肠切除、十二指肠残端关闭、胃造瘘术.供者为患者父亲,48岁,血型为AB型.患者术前应用血浆置换、利妥昔单抗与静脉注射人免疫球蛋白的联合方案去除抗B血型抗体.术中移植供者远端回肠180 cm.术后主要以他克莫司及皮质激素为主进行免疫抑制治疗.结果 受者术后15 d发生1次轻度急性排斥反应,经激素冲击及抗胸腺细胞免疫球蛋白治疗,成功逆转.由于受者胃排空障碍,术后45 d开始进流质饮食,60 d后经口进食耐受良好,后完全脱离肠外营养.随访12个月,移植肠功能良好,体质量较术前增加4 kg.供者术后6d出院,恢复良好.结论 当无ABO血型相同或相容的供者时,可以考虑行血型不合的小肠移植,但应注意选择合适的受者,采取安全有效的免疫抑制方案.%Objective To summarize the therapeutic experience of one case of an ABO incompatible living-related intestinal transplantation with an 18-month follow-up.Method A 16-yearold girl was referred with suspected bowel infarction secondary to superior mesenteric thrombosis.Exploratory laparotomy revealed an extensive bowel necrosis,requiring removal of the third and fourth part of the duodenum,the entire small bowel and the ascending and the proximal transverse colon.The duodenum was closed just distal to the ampulla of Vater and a gastrostomy tube was placed for drainage.After discussion with her family,we decided to undertake a living-related intestinal transplantation.Lab tests indicated her B blood-type but absence of ABO identical or compatible donors in her family.During a long waiting period for a cadaveric donor,she developed several episodes of recurrent aspiration and the lung cavitation.Her 48-year-old father with an AB blood-type was considered as donor.Induction therapy included

  17. Prenatal diagnosis of a case with anencephaly-omphalocele-unilateral absent radial ray.

    Science.gov (United States)

    Ceylaner, S; Ceylaner, G; Altun, M; Coşkun, A; Danisman, N

    2009-01-01

    We report here a female fetus with anencephaly, omphalocele and unilateral radial aplasia. The combination of two of these three malformations were reported in a number of patients diagnosed as Gershoni-Barush syndrome, ORR phenotype, VATER association, Schisis association, OEIS complex, Schinzel phocomelia syndrome and Acalvaria but they have not been reported all together in the same patient up to date. We hypothesize that, some or all these syndromes given above may be related etiologically.

  18. Ab Initio structure determination of vaterite by automated electron diffraction.

    Science.gov (United States)

    Mugnaioli, Enrico; Andrusenko, Iryna; Schüler, Timo; Loges, Niklas; Dinnebier, Robert E; Panthöfer, Martin; Tremel, Wolfgang; Kolb, Ute

    2012-07-09

    "This is a mineral about which there has been much discussion" is a typical statement about vaterite in older standard textbooks of inorganic chemistry. This polymorph of CaCO(3) was first mentioned by H. Vater in 1897, plays key roles in weathering and biomineralization processes, but occurs only in the form of nanosized crystals, unsuitable for structure determination. Its structure could now be solved by automated electron diffraction tomography from 50 nm sized nanocrystals.

  19. The Manipulation effectivity of cell co-cultures in 5% CO2 incubation system to increase in vitro cattle embryo production

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    Ferry Lismanto Syaiful

    2010-03-01

    Full Text Available The purpose of this research is to determine the effectivity of various cell co-cultures of cattle embryo production by in vitro CO2 5% incubation system and get the best cell co-culture. Cell co-culture which are used in the synthesis is the oviduct cells, isthmus cells, ampulla cells, follicle cells and without cells. Data were analyzed based on completely randomized desiggn. The average growth rate/ cleavage in various cell culture was: the oviduct cell 59.24%, ampulla cell 58.69%, isthmus cell 58.25%, follicle cell 52.24% and without cells 47.76%. The average growth of 8-16 cells embryos to various cell co-culture was: the oviduct cell 46.02%, ampulla cell 45.45%, isthmus cell 45.15%, follicle cell 43.07%, and without cell 38.50%. The mean percentage of morula in various cell co-culture treatment was: the oviduct cell 20.59%, ampulla cell 20.48%, isthmus cell 20.30%, follicle cell 16.96% and without cell 12.58%. The average percentage of embryonic growth (cleavage, 8-16 cells and morula was not significantly different (P > 0.05. The treatment of a variety of cell co-culture increased significantly (P>0.05, blastocysts production, namely: the oviduct cell 3.28%, ampulla cell 3.22%, isthmus cell 3.08%, follicle cell 2.45% and without cell 1.97%. In conclusion, the treatment of various cell co-culture in 5%CO2 incubation system can increace the growth of cattle embryos in vitro.

  20. Rapid Recovery from Acute Liver Failure Secondary to Pancreatoduodenectomy-Related Non-Alcoholic Steatohepatitis

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    Kazushige Nirei

    2013-01-01

    Full Text Available This report describes a case of liver failure secondary to pancreatoduodenectomy and rapid recovery following treatment. A 68-year-old woman with cancer on the ampulla of Vater underwent surgery for pancreatoduodenectomy. The patient developed liver failure 3 months postsurgically. She was hospitalized after presenting with jaundice, hypoalbuminemia and decreased serum zinc. Computed tomography (CT of the abdomen showed a reduction in CT attenuation values postoperatively. We suspected fatty liver due to impaired absorption caused by pancreatoduodenectomy. We initiated treatment with branched-chain amino acids and a zinc formulation orally. Trace elements were administered intravenously. Two months after treatment, there was a noticeable improvement in CT findings. The patient’s jaundice and hypoalbuminemia prompted a liver biopsy, which led to a diagnosis of non-alcoholic steatohepatitis.

  1. Reporting tumor molecular heterogeneity in histopathological diagnosis.

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    Andrea Mafficini

    Full Text Available Detection of molecular tumor heterogeneity has become of paramount importance with the advent of targeted therapies. Analysis for detection should be comprehensive, timely and based on routinely available tumor samples.To evaluate the diagnostic potential of targeted multigene next-generation sequencing (TM-NGS in characterizing gastrointestinal cancer molecular heterogeneity.35 gastrointestinal tract tumors, five of each intestinal type gastric carcinomas, pancreatic ductal adenocarcinomas, pancreatic intraductal papillary mucinous neoplasms, ampulla of Vater carcinomas, hepatocellular carcinomas, cholangiocarcinomas, pancreatic solid pseudopapillary tumors were assessed for mutations in 46 cancer-associated genes, using Ion Torrent semiconductor-based TM-NGS. One ampulla of Vater carcinoma cell line and one hepatic carcinosarcoma served to assess assay sensitivity. TP53, PIK3CA, KRAS, and BRAF mutations were validated by conventional Sanger sequencing.TM-NGS yielded overlapping results on matched fresh-frozen and formalin-fixed paraffin-embedded (FFPE tissues, with a mutation detection limit of 1% for fresh-frozen high molecular weight DNA and 2% for FFPE partially degraded DNA. At least one somatic mutation was observed in all tumors tested; multiple alterations were detected in 20/35 (57% tumors. Seven cancers displayed significant differences in allelic frequencies for distinct mutations, indicating the presence of intratumor molecular heterogeneity; this was confirmed on selected samples by immunohistochemistry of p53 and Smad4, showing concordance with mutational analysis.TM-NGS is able to detect and quantitate multiple gene alterations from limited amounts of DNA, moving one step closer to a next-generation histopathologic diagnosis that integrates morphologic, immunophenotypic, and multigene mutational analysis on routinely processed tissues, essential for personalized cancer therapy.

  2. Reporting Tumor Molecular Heterogeneity in Histopathological Diagnosis

    Science.gov (United States)

    Mafficini, Andrea; Amato, Eliana; Fassan, Matteo; Simbolo, Michele; Antonello, Davide; Vicentini, Caterina; Scardoni, Maria; Bersani, Samantha; Gottardi, Marisa; Rusev, Borislav; Malpeli, Giorgio; Corbo, Vincenzo; Barbi, Stefano; Sikora, Katarzyna O.; Lawlor, Rita T.; Tortora, Giampaolo; Scarpa, Aldo

    2014-01-01

    Background Detection of molecular tumor heterogeneity has become of paramount importance with the advent of targeted therapies. Analysis for detection should be comprehensive, timely and based on routinely available tumor samples. Aim To evaluate the diagnostic potential of targeted multigene next-generation sequencing (TM-NGS) in characterizing gastrointestinal cancer molecular heterogeneity. Methods 35 gastrointestinal tract tumors, five of each intestinal type gastric carcinomas, pancreatic ductal adenocarcinomas, pancreatic intraductal papillary mucinous neoplasms, ampulla of Vater carcinomas, hepatocellular carcinomas, cholangiocarcinomas, pancreatic solid pseudopapillary tumors were assessed for mutations in 46 cancer-associated genes, using Ion Torrent semiconductor-based TM-NGS. One ampulla of Vater carcinoma cell line and one hepatic carcinosarcoma served to assess assay sensitivity. TP53, PIK3CA, KRAS, and BRAF mutations were validated by conventional Sanger sequencing. Results TM-NGS yielded overlapping results on matched fresh-frozen and formalin-fixed paraffin-embedded (FFPE) tissues, with a mutation detection limit of 1% for fresh-frozen high molecular weight DNA and 2% for FFPE partially degraded DNA. At least one somatic mutation was observed in all tumors tested; multiple alterations were detected in 20/35 (57%) tumors. Seven cancers displayed significant differences in allelic frequencies for distinct mutations, indicating the presence of intratumor molecular heterogeneity; this was confirmed on selected samples by immunohistochemistry of p53 and Smad4, showing concordance with mutational analysis. Conclusions TM-NGS is able to detect and quantitate multiple gene alterations from limited amounts of DNA, moving one step closer to a next-generation histopathologic diagnosis that integrates morphologic, immunophenotypic, and multigene mutational analysis on routinely processed tissues, essential for personalized cancer therapy. PMID:25127237

  3. KRAS mutation as a prognostic factor in ampullary adenocarcinoma: a meta-analysis and review

    Science.gov (United States)

    Kim, Bum Jun; Jang, Hyun Joo; Kim, Jung Han; Kim, Hyeong Su; Lee, Jin

    2016-01-01

    Ampullary adenocarcinoma (A-AC) is a rare malignancy arising from the ampulla of Vater. KRAS mutation is detected in 30–40% of patients with A-AC, but its clinical implication and prognostic value are not well described. We conducted this meta-analysis to investigate the association between KRAS mutation and prognosis in patients with A-AC. We searched Pubmed, MEDLINE, EMBASE, and the Cochrane Library databases for articles including following terms in their titles, abstracts, or keywords: ‘ampullary or periampullary or ampulla of vater’, ‘cancer or carcinoma’, and ‘KRAS’. There were five studies with survival data of patients. A total of 388 patients with A-AC from the 5 studies were included in the overall survival (OS) analysis, and 169 patients from 2 studies were eligible for the relapse-free-survival (RFS) analysis. Out of 388 patients, 175 (45%) had KRAS mutation. There was no association between KRAS mutation and OS (HR = 1.06, 95% CI: 0.87–1.29, P = 0.58). However, there was a significant correlation between KRAS mutation and worse RFS (HR = 2.74, 95% CI: 1.52–4.92, P = 0.0008). In conclusion, this meta-analysis indicates that KRAS mutation is associated with poor RFS, but not with OS in patients with A-AC. PMID:27517148

  4. Role of MRCP Imaging of Gallbladder Triangle in Predicting Difficulty of Laparoscopic Cholecystectomy%磁共振胆胰管成像中胆囊三角的解剖关系对预测腹腔镜胆囊切除术难度的价值

    Institute of Scientific and Technical Information of China (English)

    孙荣勋; 张华云; 吉学生; 俞建平; 石长青; 章勇; 李吉; 陈润浩

    2011-01-01

    目的:探讨磁共振胆胰管成像(MRCP)中胆囊三角解剖结构的显像对预测腹腔镜胆囊切除术(LC)手术难度的价值.方法:对232例LC病例术前行MRCP检查,记录胆囊管能否显示、胆囊管开口位置、胆囊壶腹和胆囊管的毗邻关系、壶腹部胆囊壁厚度、胆囊壶腹和胆总管的毗邻关系、胆囊颈部有无结石嵌顿、胆囊内有无胆汁,将这些变量与胆囊三角的解剖时间做Logistic回归分析.结果:MRCP中胆囊管显示不清胆囊壶腹和胆囊管的、兔尾型毗邻关系、胆囊管开口于壶腹中份、壶腹部胆囊壁增厚均能提示手术难度增加.结论:MRCP中胆囊三角结构显像能预测LC手术难度.%Objective:To evaluate MRCP imaging of gallbladder triangle in predicting difficulty of laparoscopic cholecystectomy. Methods:A total of 232 patients received MRCP examination, and the following data were recorded: presence of cystic duct imaging, location of cystic duct entrance, relationship between cystic ampullae and cystic duct, presence of stone incarceration in cystic cervix, thickness of cystic ampullae wall, relationship between cystic ampullae and common bile duct, presence of bile imaging in cyst. Logistic regression analysis was performed to analyse the dissecting time of gallbladder triangle and above data. Results:The following findings prompt difficult operation that are no imaging of cystic duct, type of rabbit tail of relationship between cystic ampullae and duct, cystic duct stating at the middle of ampullae and thicker ampullae wall. Conclusions: MRCP findings on gallbladder triangle can predict difficulty of LC.

  5. A study of morphometric variations of fallopian tube in female foetuses

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    Toleti Sarada

    2015-05-01

    Conclusion: Majority of the foetuses length of the fallopian tubes vary from 5-8 cm. Single tube absent in two foetuses, one foetus left side complete absence and another foetus right side absence of ampulla, infundibulum and fimbria i.e. of about 6% congenital absence of tube is important for obstetricians for treating infertility. [Int J Res Med Sci 2015; 3(5.000: 1041-1045

  6. Electrical Resistivity of an Elasmobranch's Ampullary Jelly in Varying Electric and Magnetic Fields

    Science.gov (United States)

    Brown, Brandon; Hughes, Mary E.

    2001-03-01

    The ampullae of Lorenzini are believed to function as the electroreceptive organs in elasmobranch fishes. Though the entire excised organs have been the subject of electrical transport measurements, the jelly that fills the ampullae -- composed primarily of glycoproteins with proteins and dissolved salts -- has received less scrutiny. The specific electromagnetic properties of the jelly contribute to electroreception, and we hope to supply useful parameters to modeling efforts via precise electrical characterization. We report preliminary resistivity measurements from ampullary jelly removed, post mortem, from an adult triaenodon obesus (white-tip reef shark). We present data over a broad range of applied electrical currents. We also present data of the resistivity as a function of applied magnetic field strength.

  7. The role of perilymph in the response of the semicircular canals to angular acceleration.

    Science.gov (United States)

    Anliker, M.; Van Buskirk, W.

    1971-01-01

    A new model for the response of the semicircular canals to angular motion is postulated. This model is based on evidence that the bony canal is not compartmentalized and assumes that the ampulla wall is highly flexible. It is shown that the perilymph induces a cupula displacement far greater than that produced by the endolymph alone. The predicted dynamic behavior of the canals on the basis of this model is found to be consistent with experimental observations.

  8. The role of perilymph in the response of the semicircular canals to angular acceleration. [dynamic model for perilymph induced displacement of cupula

    Science.gov (United States)

    Anliker, M.; Vanbuskirk, W.

    1973-01-01

    A new model for the response of the semicircular canals to angular motion is postulated. This model is based on evidence that the bony canal is not compartmentalized and assumes that the ampulla wall is highly flexible. It is shown that the perilymph induces a cupula displacement far greater than that produced by the endolymph alone. The predicted dynamic behavior of the canals on the basis of this model is found to be consistent with experimental observations.

  9. What's in the Gift? Towards a Molecular Dissection of Nuptial Feeding in a Cricket.

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    Yannick Pauchet

    Full Text Available Nuptial gifts produced by males and transferred to females during copulation are common in insects. Yet, their precise composition and subsequent physiological effects on the female recipient remain unresolved. Male decorated crickets Gryllodes sigillatus transfer a spermatophore to the female during copulation that is composed of an edible gift, the spermatophylax, and the ampulla that contains the ejaculate. After transfer of the spermatophore, the female detaches the spermatophylax and starts to eat it while sperm from the ampulla are evacuated into the female reproductive tract. When the female has finished consuming the spermatophylax, she detaches the ampulla and terminates sperm transfer. Hence, one simple function of the spermatophylax is to ensure complete sperm transfer by distracting the female from prematurely removing the ampulla. However, the majority of orally active components of the spermatophylax itself and their subsequent effects on female behavior have not been identified. Here, we report the first analysis of the proteome of the G. sigillatus spermatophylax and the transcriptome of the male accessory glands that make these proteins. The accessory gland transcriptome was assembled into 17,691 transcripts whilst about 30 proteins were detected within the mature spermatophylax itself. Of these 30 proteins, 18 were encoded by accessory gland encoded messages. Most spermatophylax proteins show no similarity to proteins with known biological functions and are therefore largely novel. A spermatophylax protein shows similarity to protease inhibitors suggesting that it may protect the biologically active components from digestion within the gut of the female recipient. Another protein shares similarity with previously characterized insect polypeptide growth factors suggesting that it may play a role in altering female reproductive physiology concurrent with fertilization. Characterization of the spermatophylax proteome provides the

  10. Distribution of lymphocytes, immunoglobulin-containing cells, macrophages, and dendritic cells in the accessory sex glands of rams experimentally infected with Actinobacillus seminis

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    Jorge Acosta-Dibarrat

    2016-05-01

    Full Text Available Abstract: The distribution of cells involved in the immune response in accessory sex glands of rams experimentally infected with Actinobacillus seminis was studied. Twelve one-year old rams were experimentally infected by intraurethral (IU (n=4 and intraepididymal (IE (n=4 route, and four control (CON animals were used. The animals were slaughtered 35 days post-inoculation, samples were taken from accessory sex glands, and bacteriology and histopathology tests were performed. The presence of CD4, CD8 and TCRγδ (WC1 lymphocytes, CD45RO cells, macrophages (CD14, dendritic cells (CD1b, IgA-, IgG- and IgM-containing cells (IgCC was determined. Animals of the IE group developed clinical epididymitis. No lesions were seen in rams of the IU group; two of the intraepididymal inoculated CON developed small lesions in the epididymis. A. seminis isolates were achieved from 6:16 (37.5% accessory sex glands in the IE group, but not in the IU and CON groups. In the CON group, IgA- and IgM- containing cells predominated in the bulbourethral glands and the disseminated prostate, and they were scarce or null in the vesicles and ampullae. A significant increase of IgA-, IgG- and IgM- containing cells was confirmed in the seminal vesicles, the ampullae and the bulbourethral glands in the IE group. In the IE and IU groups, an increase in CD4, CD8, WC1, CD45RO and CD14 was evidenced in the vesicles and ampullae. CD1b dendritic cells were present in the ampullae and vesicles with inflammatory processes. A. seminis triggered a local immune response in the IE and IU groups. These results indicate a different pattern of infiltrating immune cells in the accessory sex glands of infected A. seminis rams.

  11. Spontaneous motility of the pig oviduct in vitro.

    Science.gov (United States)

    Rodriguez-Martinez, H; Einarsson, S; Larsson, B; Akusu, M; Settergren, I

    1982-02-01

    The spontaneous motility of the pig oviductal isthmus and ampulla during the estrous cycle was recorded in vitro using an intraluminally located pressure microtransducer. A very high motility was recorded in the isthmic portion throughout the whole cycle, while the ampulla revealed an active pattern during the periovulatory period only. In proestrus the tubal pattern in both segments consisted of regular contractions of high frequency, increasing in amplitude when approaching estrus. During heat the motility changed abruptly, and was characterized by the presence of regular strong waves in the two tubal segments. This pattern might contribute to the transport of gametes to the fertilization site. After ovulation, during the time when ova are retained in the oviducts, the high preovulatory peaks disappeared. The isthmic pattern showed regular phasic contractions of high frequency and amplitude, while the ampullar motility was low. The ova are arrested at the level of the ampullar-isthmic junction (AIJ) during this period. During the short period when eggs are passing to the uterus, the ampullar motility remained low, while the isthmus showed a very active pattern with the presence of heavy contractions. This suggests the active participation of the isthmus in ovum descent. During the rest of the luteal phase, the ampulla maintained its stable low motility, while the isthmus showed an irregular although still active pattern characterized by heavy outbursts of increased activity superimposed on a consistent basal contractility.

  12. Ampullary organ morphology of freshwater salmontail catfish, Arius graeffei.

    Science.gov (United States)

    Whitehead, D L; Tibbetts, I R; Daddow, L Y

    2000-11-01

    Two types of ampullary organs are present in the skin of the freshwater salmontail catfish, Arius graeffei, each consisting of a short canal (0.2-0.5 mm) oriented perpendicular to the basement membrane and ending in an ampulla. Histochemical staining techniques (Alcian blue and Lillie's allochrome) indicate that the ampullary canals contain an acidic mucopolysaccharide gel, which is uniform in its staining properties along the canals. Type II ampullary organs consist of a canal, the wall of which is lined with cuboidal epithelial cells. The canal opens into an ampulla with 50-60 receptor cells. Electron microscopy reveals that the pear-shaped receptor cells bear microvilli on their luminal surface and lie adjacent to an unmyelinated neuron. Type III ampullary organs differ from Type II in that the canal wall consists of cells that possess a protein-rich sac at the luminal apex and have a polymorphic nucleus. The canals of Type III ampullary organs open to an ampulla with 8-30 receptor cells similar in both staining properties and structure to those of the Type II organ. In both types of ampullary organs, supportive cells surround each receptor cell except at the apex of the receptor cell.

  13. Efficacy of Black Tea as a Negative Oral Contrast Agent for MR Cholangiopancreatography (MRCP

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    Amir Hossein Jalali

    2010-05-01

    Full Text Available Background/Objective: Evaluation of the use of black tea as negative oral contrast agent in MR cholangiopancreatography (MRCP."nPatients and Methods: Thirty-five patients (mean age, 50.3±19.2 years, who were referred for MRCP, entered in this study. MRCP was performed before, after 5 minutes and after 15 minutes following consumption of 300 ml of black tea. Depiction of the gall bladder, cystic duct, proximal and distal parts of the common bile duct (CBD, intra hepatic ducts, ampula of Vater, main pancreatic duct (MPD and signal loss of the stomach and three different segments of the duodenum were investigated according to VAS and Lickert scores."nResults: Regarding visibility of seven different anatomical parts of the pancreatobiliary tree (gall bladder, cystic duct, CBD, common hepatic duct, intrahepatic duct, ampula of Vater and MPD, the post procedure images were better visualized only in the distal part of CBD, ampula of vater and MPD both in Lickert and VAS scoring (all Ps≤0.001."nThere was no significant difference between the images 5 and 15 minutes after tea consumption. Regarding the obliteration of high signal in the stomach and three different parts of the duodenum, all post tea images of the mentioned parts showed significant disappearance of high signal in Lickert and VAS scoring systems (all Ps≤0.001. "nConclusion: Black tea is an affordable, cheap, available, safe, and efficient oral negative contrast agent for MRCP which reduces the signal intensity of fluids in the gastrointestinal tract and is also efficient for better depiction of MPD, distal part of CBD and ampula.

  14. Application of Posterior Triangulation Approach with Drawing Cholecyst Ampulla and Observing Rouviere Ditch in Laparoscopic Cholecystectomy%提壶腹看Rouviere沟后三角入路法在腹腔镜胆囊切除中的应用

    Institute of Scientific and Technical Information of China (English)

    刘斌; 刘坤; 黄侣新; 柏磊; 陈江

    2013-01-01

    目的 探讨腹腔镜胆囊切除术(LC)中采用提胆囊壶腹、看Rouviere沟、胆囊后三角入路法切除胆囊,对成功完成LC和预防胆管、血管损伤的临床意义.方法 2009年7月至2011年12月期间应用提胆囊壶腹、看Rouviere沟、从胆囊后三角入路法(研究组)切除胆囊112例,同期常规方法(对照组)行LC 55例,比较2组的临床疗效.结果 2组一般临床资料比较差异无统计学意义(P>0.05),具有可比性.研究组112例成功完成了LC,无中转开腹及并发症发生.对照组55例LC发生并发症3例,其中2例胆管损伤及1例左肝动脉损伤.研究组的并发症发生率明显低于对照组[0(0/112)比5.45% (3/55),P<0.05],研究组和对照组间术中出血量、手术时间、住院时间及中转开腹率差异均无统计学意义[术中出血量:(8.95±3.95) mL比(8.09±3.91) mL,P-0.189;手术时间:(84.72±37.15) min比(77.05±37.22) min,P-0.212;住院时间:(6.40±2.39)d比(7.02±3.41)d,P=0.178].结论 在LC中,采用提胆囊壶腹、看Rouviere沟、从胆囊后三角入路法,相对容易精准解剖壶腹部与胆囊管移行区,完整显露胆囊壶腹部、胆囊管、胆总管及胆囊动脉,既是成功完成LC的保证,又可有效避免术中胆管和血管的损伤.

  15. A 56-year-old woman with ampullary adenocarcinoma and acute pancreatitis Mujer de 56 años con adenocarcinoma de la ampolla de Vater y pancreatitis aguda

    Directory of Open Access Journals (Sweden)

    V. M. Santos

    2012-12-01

    Full Text Available A 56-year-old woman was admitted with jaundice, and laboratory data were indicative of pancreatitis, which recurred in spite of adequate clinical and nutritional management. The patient was an overweight diabetic using metformin, who had antecedents of cholelithiasis and recent cholecystectomy. Clinical and laboratory features were not conclusive about the cause of this acute pancreatitis. However, imaging data contributed to diagnosis suspicion, and the histopathology study of the transpapillary biopsy confirmed the ampullary adenocarcinoma. Whipple´s surgery was the procedure of choice, associated with radical lymphadenectomy, followed by an uneventful outcome. Recrudescence of signs and symptoms of acute pancreatitis, with elevated serum levels of bilirrubins and of hepatic canalicular enzymes, should enhance the suspicion index about periampullary tumors. High levels of CA 19-9 can constitute a useful marker of this condition. Transpapillary biopsy can characterize the diagnosis of ampullary malignancies.Se presenta el caso de una mujer de 56 años, que presentaba ictericia y cuyos exámenes de laboratorio fueran indicativos de pancreatitis. Presentó recurrencia a pesar de las medidas clínicas y nutricionales adecuadas. La paciente era diabética, con sobrepeso, tomaba metformina y con antecedentes de colelitiasis y reciente colecistectomía. Los datos clínicos y del laboratorio no fueron concluyentes acerca del origen de esta pancreatitis aguda. Sin embargo, los estudios de imagen contribuyeron a la sospecha del diagnóstico; los estudios de citologia exfoliativa y de biopsia transpapilar confirmaron un adenocarcinoma ampular. La cirugía de Whipple fue el procedimiento de opción, asociado con linfadenectomía radical, con resultado favorable. El recrudecimiento de señales y síntomas de pancreatitis aguda, con niveles séricos elevados de bilirrubina y de enzimas hepáticos debe reforzar el índice de sospecha acerca de tumores

  16. Larval Fish of Selected Aquatic Habitats on the Lower Mississippi River.

    Science.gov (United States)

    1983-02-01

    high stages, with an 18.7-m difference in vater level. The aver- age water velocity within the main channel is from 0.9 to 1.9 a/sec with a maximum...flowmeter readings . In the case of the habitat comparisons, stations representing the locations (e.g., main channel or Carolina Revetment) were pooled...34Larval Suckers (Pisces- Catostomidae ) from the Lower Mississippi River," Association of Southeastern Biologists Bulletin, Vol 25, No. 2, p 56. ! ! 1979a

  17. Microanatomy of the carunculae major artery and its clinical significance%十二指肠大乳头血供的临床解剖学研究

    Institute of Scientific and Technical Information of China (English)

    张国飞; 石小田

    2015-01-01

    Objective To provide exact and reliable morphological data for the operation of endoscop-ic sphincterotomy (EST). Method (1) 20 cadeveric duodenum and pancreas were perfused with latex. (2) The resource, number, diameter, branches of all carunculae major arteries of these specimens and the distance from vascular origin to Vater bulb, the inner margin of duodenum and carunculae major were observed. Results (1) Carunculae major arteries originated from the anterior and posterior arterial arches, and each had two branches. The diameter of the two branches of the anterior carunculae major artery was (1.3±0.1) mm and (1.0±0.2) mm. The distance from the vascular origin of the two branches to the Vater’s ampulla, the inner mar-gin of duodenum and carunculae major was (5.7 ± 0.6) mm and (6.0 ± 0.4) mm, (8.7 ± 1.1) mm and (9.7 ± 1.7) mm, (16±0.9) mm and (16±1.5) mm, respectively. The diameter of the two branches of the posterior caruncu-lae major artery was (0.62 ± 0.02) mm and (0.98 ± 0.06) mm. The distance from the vascular origin of the two branches to Vater’s ampulla, the inner margin of duodenum and carunculae major were (11 ± 0.7) mm and (16.4±0.4) mm ,(13±0.3) mm and (17.9±0.3) mm, (16±0.7) mm and (19.2±0.6) mm, respectively. (2) The first branch of the anterior carunculae major arteries was at the direction 10~11 o'clock and the second branch was at the position 2~3 o'clock. The first branch of the posterior carunculae major arteries was at the position of 8~9 o'clock and the second branch was at the position of 4~5 o'clock. The branches of carunculae major arteries were primarily located at the position of 8~11 o'clock and secondarily at the position of 2~5 o'clock, and least at 11~1 as well as 6~7 o'clock. Conclusion In EST the incision should be made at the direction of 11~1 or 6~7 o'clock.%目的:为内窥镜下十二指肠乳头括约肌切开术( EST)与内镜乳头气囊扩张术(EPBD)取结石术提供形态学依据。方法(1)20例

  18. Ultrastructure study of the excretory system and the genital primordium of the infective stage of Onchocerca volvulus (Nematoda:Filarioidea).

    Science.gov (United States)

    Strote, G; Bonow, I

    1995-01-01

    The electron microscopic investigation of the anterior part of the infective third-stage juvenile of Onchocerca volvulus provides first insights into the structure of the excretory system of this developmental stage of the parasite. The most anterior part of this system consists of a cell process of the syncytial excretory cells. At this height the excretory cells enclose the cuticle-lined excretory channel. The channel is in the process of elongation in the anterior-posterior direction, indicated by cell division in this region. More posteriad an ampulla-like structure is forming in the cytoplasm of the excretory cells. The inner surface of this ampulla is lined with a small number of single microvilli. In this part of the system the cytoplasm of the excretory cells is rich in Golgi bodies and endocytic vesicles. The ampulla has direct access to the exterior by the excretory duct. The excretory duct is a cuticle-lined structure surrounded by supporting fibres of an additional cell. This duct cell connects the excretory duct to the body-wall cuticle at the excretory pore. Adjacent to the region of the excretory system a cell is found that resembles a gland cell. This cell is in close contact to the ventral nerve cord. The genital primordia of the third-stage juvenile consist of several dividing cells. The female genital primordium is seen at the junction of the muscular with the glandular oesophagus and the male primordium can be found at the junction of the glandular oesophagus with the gut.

  19. Biliary endoprosthesis

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jung Hyeok; Kim, Yong Sun; Jang, Byung Won; Kim, Tae Hun; Kim, Yong Joo; Kang, Duk Sik [Kyungpook National University College of Medicine, Daegu (Korea, Republic of)

    1986-02-15

    Biliary endoprosthesis could provide permanent internal biliary drainage in patient with obstructive jaundice with advantages of absence of troublesome external catheter and no loss of fluid, bile and electrolytes over external drainage. Incidence of sepsis and cholangitis be lowered. Endoprosthesis was performed in 18 patients of obstructive jaundice from January, 1985 to December, 1985 at Department of Radiology, Kyungpook National University Hospital. The results are as follows 2. The cases of obstructive jaundice included bile duct cancer in 11, stomach ca. metastasis in 3, ca. of ampulla of Vater in 1, ca. of head of pancreas in 1, CBD cancer with postop. recurrence in 1, and impacted CBD stone in 1 case. 2. The levels of obstruction were at the trifurcation in 8, CHD in 5, proximal CBD in 3, and distal CBD in 2 cases. 3. Decline of serum bilirubin level was noted in 15 cases with the most rapid decline within 1 week after the procedure. 4. The complication occurred in 5 cases. The three cases were recovered spontaneously, but one died of bile peritonitis, another experienced obstruction of endoprosthesis. 5. The endoprosthesis is beneficial in treatment of obstructive jaundice for which surgery is not indicated, and saving expensive abdominal surgery and less advantageous percutaneous external drainage, hence enhancing life quality.

  20. Pancreaticobiliary reflux as a high-risk factor for biliarymalignancy: Clinical features and diagnostic advancements

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Pancreaticobiliary junction is composed of complexstructure with which biliary duct and pancreatic ductassemble and go out into the ampulla of Vater duringduodenum wall surrounding the sphincter of Oddi.Although the sphincter of Oddi functionally preventsthe reflux of pancreatic juice, pancreaticobiliary reflux(PBR) occurs when function of the sphincter of Oddihalt. The anatomically abnormal junction is termedpancreaticobiliary maljunction (PBM) and is characterizedby pancreatic and bile ducts joining outside of theduodenal wall. PBM is an important anatomical findingbecause many studies have revealed that biliarymalignancies are related due to the carcinogenetic effectof the pancreatic back flow on the biliary mucosa. Onthe other hand, several studies have been published onthe reflux of pancreatic juice into the bile duct withoutmorphological PBM, and the correlation of such caseswith biliary diseases, especially biliary malignancies, isdrawing considerable attention. Although it has longbeen possible to diagnose PBM by various imagingmodalities, PBR without PBM has remained difficult toassess. Therefore, the pathological features of PBRwithout PBM have not been yet fully elucidated. Lately,a new method of diagnosing PBR without PBM hasappeared, and the features of PBR without PBM shouldsoon be better understood.

  1. Photodynamic therapy in gastrointestinal cancer: a realistic option?

    Science.gov (United States)

    Barr, H

    2000-02-01

    Photodynamic therapy is now a useful and practical option of the local treatment of gastrointestinal cancers. There is increasing screening and surveillance of patients at risk of oesophageal and gastric cancers. The early detection of disease is often unhelpful if an elderly or frail patient needs to be subjected to radical resectional surgery. Photodynamic therapy can eradicate and cure early mucosal disease following a single endoscopic treatment. If the disease is more advanced good local control and palliation is often possible. Overall, palliation can often be achieved using simpler methods which are highly effective and not associated with the problems of prolonged photosensitisation. It is rapidly becoming clear that the ideal indication is for the treatment of dysplastic lesions in the oesophagus associated with columnar-lined oesophagus (Barrett's oesophagus). In these circumstances a heterogeneous field change often with multifocal dysplasia or cancer can be widely eradicated. Similar areas of squamous dysplasia in the upper oesophagus can be treated. At present a major complication of stricture formation is associated with the use of some photosensitisers. The treatment of cancer at the ampulla of Vater and choriocarcinoma is also proving very effective. The treatment can be performed at endoscopy and is well tolerated and safe.

  2. The Rare Cancer Network: ongoing studies and future strategy

    Directory of Open Access Journals (Sweden)

    Mahmut Ozsahin

    2014-08-01

    Full Text Available The Rare Cancer Network (RCN was formed in the early 1990’s to create a global network that could pool knowledge and resources in the studies of rare malignancies whose infrequency prevented both their study with prospective clinical trials. To date, the RCN has initiated 74 studies resulting in 46 peer reviewed publications. The First International Symposium of the Rare Cancer Network took place in Nice in March of 2014. Status updates and proposals for new studies were heard for fifteen topics. Ongoing studies continue for cardiac sarcomas, thyroid cancers, glomus tumors, and adult medulloblastomas. New proposals were presented at the symposium for primary hepatic lymphoma, solitary fibrous tumors, Rosai-Dorfman disease, tumors of the ampulla of Vater, salivary gland tumors, anorectal melanoma, midline nuclear protein in testes carcinoma, pulmonary lymphoepithelioma-like carcinoma, adenoid cystic carcinoma of the trachea, osteosarcomas of the mandible, and extra-cranial hemangiopericytoma. This manuscript presents the abstracts of those proposals and updates on ongoing studies, as well a brief summary of the vision and future of the RCN.

  3. Larval structure of Passalus gravelyi and sexual dimorphism in Passalid larvae.

    Science.gov (United States)

    Mattos, Ingrid; Mermudes, José Ricardo Miras; Reyes-Castillo, Pedro

    2015-09-01

    The adults and larvae of Passalidae are subsocial insects commonly found in tropical forests, living in decaying wood gallery systems constructed by adults. Currently, few repots on the larvae of Neotropical Passalidae have been published and information is scarce. In this study, the Passalus (Pertinax) gravelyi Moreira, 1922 larvae is described for the first time, based on ten larval specimens 1 (1° instar), 4 (2° instar), and 5 (3° instar) associated with three adults collected from a single colony at the Parque Nacional do Itatiaia (Itatiaia, Rio de Janeiro, Brazil). The description was carried out based on electronic and digital photographs of diagnostic structures, with some details on the systematic of the species. The larvae of Passalus gravelyi has the general setal 'Pertinax' pattern and differed from others by 16 to 18 setae on the anal ring, the other larvae data from Brazilian species show the anal ring with 10 to 12 setae. A discussion on the presence of sexual dimorphism in 62 species of two and three instars of Passalidae larvae is provided for the first time. Besides, a description of the terminal ampulla present as a cuticular structure found in the medial-ventral area of the 9th abdominal sternite in males is also given. The terminal ampulla was only observed in the Passalidae male larvae and was not visible in female larvae. The terminal ampulla are acknowledged now in males of 64 passalid species, that are taxonomically distributed in world tropical forests, at the Oriental and Australian subfamily Aulacocyclinae (Aulacocyclini & Ceracupini) and the cosmotropical subfamily Passalinae (Solenocyclini, Macrolinini, Passalini, & Proculini).

  4. Morphometric Study of the Mare Oviductal Mucosa at Different Reproductive Stages.

    Science.gov (United States)

    Mouguelar, Horacio; Díaz, Tomás; Borghi, Damiana; Quinteros, Rolando; Bonino, Facundo; Apichela, Silvana Andrea; Aguilar, José Javier

    2015-11-01

    The objectives of this work were to describe some morphometric characteristics and to establish quantitative parameters of different regions of the equine oviductal mucosa from the isthmus, ampullary-isthmic junction (AIJ), and ampulla. Twenty-one mixed-bred mares were used for this study. Mares were selected in the following reproductive phases: anestrus, estrus, and diestrus. The left oviducts were examined with light microscopy, and rights ones were studied through the intraoviductal molds. The isthmus showed the smallest luminal area, mucosal area, epithelial perimeter, and luminal diameter. On the molds surfaces, some grooves extended as longitudinal canals, reducing their depth as they approached to the AIJ. Several small height projections, some obliquely positioned towards utero-tubal junction, were observed in all reproductive phases. These formations may represent pockets or cul-de-sacs in the basal areas of the epithelial folds. The AIJ mucosa gradually changed from the smooth isthmic region toward highly folded ampulla. The number and complexity of epithelial folds showed moderate increase in the same way that many of the morphometric parameters. Multiple curves were observed on the molds of the AIJ, creating a zigzag path in the oviductal lumen. In the ampulla, the high branched epithelial folds occupied most of the lumen, leaving a small luminal area free. A linear relationship between epithelial perimeter and mucosal area was found. The presence of glandular-like structures was observed in all the reproductive stages studied. The equine endosalpinx reveals a highly complex tridimensional arrangement where each region shows very particular and specific designs.

  5. An experimental study on a function of the cupula. Effect of cupula removal on the ampullary nerve action potential.

    Science.gov (United States)

    Suzuki, M; Harada, Y; Sugata, Y

    1984-01-01

    We used a posterior semicircular canal that had been isolated from a frog. From the utricular side the ampulla was cut open at a position one third of the way along the long axis. The cupula was removed through this opening using a glass micropipette. The action potential from the posterior ampullary nerve was recorded before and after removal of the cupula. After removal, the action potential disappeared almost completely. When the cupula was put back on the crista, the action potential was restored. When the cupula was put back upside down, the action potential recovered, but to a lesser extent.

  6. The organization of ampullary sense organs in the electric fish, Gymnarchus niloticus.

    Science.gov (United States)

    Mullinger, A M

    1969-01-01

    Three types (A, B, and C) of ampullary sense organs occur in the skin of Gymnarchus niloticus. In type A the ampulla is connected to the surface of the skin by an open duct whereas in B and C organs it is closed, though overlain by specialized epidermal cells. In each case the receptor cell surface in contact with the ampullary lumen bears microvilli; these are more highly developed in B and C organs than in type A. Fine structural observations are consistent with the view that the organs are electric receptors of three different types.

  7. 壶腹周围癌早期诊断和鉴别诊断%Eady and differential diagnosis of periampullary cancer

    Institute of Scientific and Technical Information of China (English)

    赵玉沛

    2008-01-01

    Periampullary cancer is a kind of malignant cancer of digestive tract.It arises within 2 cm of the major duodenal papilla and eomprises cancers of the ampulla,distal comliiOll bile duct,pancreas and duodenum.Their clinical features and anatomic locations are similar,as are the therapeutic approaches.However,their long-term outcomes vary.Due to the bad prognosis,it is very important to make an early,accurate diagnosis and differential diagnosis of periampullary cancer.This article summarizes some basic methods and new developments of early and differential diagnosis of poriampullary cancer.

  8. Male and female reproductive systems of Stolas conspersa (Germar (Coleoptera, Chrysomelidae, Cassidinae

    Directory of Open Access Journals (Sweden)

    Marianna V. P. Simões

    2012-03-01

    Full Text Available Male and female reproductive systems of Stolas conspersa (Germar (Coleoptera, Chrysomelidae, Cassidinae. The male and female reproductive systems of Stolas conspersa (Germar, 1824 are described and illustrated for the first time. The male reproductive system shows no difference from the subfamily pattern, which is a tubular well-developed median lobe; "Y", "V" or T-shaped tegmen; reduced pygidium; internal sac membranous and tubular; flagellum generally well developed needle-like structured and gastral spiculum absent. However, the female differs from the pattern proposed for Stolas in two aspects: ovary with 28 ovarioles and a reduced ampulla with indistinct velum.

  9. Dynamic and ultrastructural study of sphincter of Oddi in early-stage cholelithiasis in rabbits with hypercholesterolemia

    Institute of Scientific and Technical Information of China (English)

    Jing Guo Wei; Yao Cheng Wang; Fan Du; Hou Jun Yu

    2000-01-01

    AIM To study the relationship between preformation of gallstone and the kinetics and ultrastructure of sphincter of Oddi.METHODS Adult female rabbits were used and divided into 3 groups, and fed with either normal or high cholesterol diet for four or eight weeks.Each group contained eight rabbits. The manometry of sphincter of Oddi, biliary cineradiography, gallbladder volume measurement and ultrastructure observation under electron microscope were performed.RESULTS In groups Ⅰ and Ⅱ, the basal pressure in low-pressure ampulla or high pressure zone of sphincter of Oddi was elevated, the amplitude of phasic contraction was decreased and the volume of gallbladder were increased, with a significant difference (P<0.01) from those of control. Gallstones were found in group Ⅱ rabbits (7/8). Under cineradiography, low-pressure ampulla showed a spasmodic status without apparent peristaltic contraction. Under electron microscope, inside the muscular cells of sphincter of Oddi,loosening of microfilament and swelling of plasmosomes which congregated at the top were observed. The amount showed no obvious change under nitric oxide synthase (NOS) stain.CONCLUSION Twisting of the microfilament and disarrangement of kink macula densa inside the muscular cells suggested that the sphincter of Oddi was under spasmodic status. The impaired diastolic function caused and aggravated the stasis of cystic bile. The swelling plasmosome could be one of the important factors in elevating the tonic pressure of sphincter of Oddi.

  10. Ascariasis of the pancreatic duct.

    Science.gov (United States)

    Klimovskij, Michail; Dulskas, Audrius; Kraulyte, Zita; Mikalauskas, Saulius

    2015-09-15

    Ascariasis is a common helminthic disease worldwide, although Lithuania and other European countries are not considered endemic areas. The presence of the Ascaris worm in the biliary tree causes choledocholithiasis-like symptoms. We report a case of pancreatic duct ascariasis causing such symptoms. A 73-year-old Lithuanian woman underwent endoscopic retrograde cholangiopancreatography (ERCP) suspecting choledocholithiasis. Contrast injection into the common bile duct demonstrated a slightly dilated biliary tree without any filling defects, and the tail of an Ascaris worm protruding from the opening of the papilla Vater. The worm was captured by a snare but escaped deep into the duct. After a small wirsungotomy the worm was retrieved from the pancreatic duct. The patient received a 150 mg dose of levamisole orally repeated 7 days later and was discharged after complete resolution of symptoms. This first reported sporadic case of pancreatic duct ascariasis in Lithuania was successfully treated with ERCP and Levamisole.

  11. Structural characteristics and development of ampullary organs in Acipenser naccarii.

    Science.gov (United States)

    Camacho, Susana; Ostos, Maria Del Valle; Llorente, José Ignacio; Sanz, Ana; García, Manuel; Domezain, Alberto; Carmona, Ramón

    2007-09-01

    Ampullary organs of Acipenser naccarii sturgeons were examined by optical and electronic microscopy (transmission electron microscopy and scanning electron microscopy) from hatching until 1 month later when the juvenile phase is completely established. It was observed that, when A. naccarii begins to feed actively, the ultrastructural characteristics of ampullary organs already correspond to those of adult animals. These organs may, therefore, be functional and, together with taste buds, facilitate food search after exhaustion of yolk sac food reserves. Mature ampullary organs of A. naccarii are formed by an ampulla that communicates with the exterior by means of a short channel. These ampullae correspond to the sensory portion of these receptors and are formed by two cell types: receptor cells and support cells. Receptor cells present a kinocilium on their free surface and establish ribbon synapses with axon nerve endings that arise from the underlying conjunctive tissue. Support cells enclose receptor cells, bear stereocilia and occasional cilia, and are of a secretory nature. The mucus associated with ampullary organs mainly comprises neutral mucopolysaccharides, whereas mucopolysaccharides are usually acid in other fish groups.

  12. Minute ampullary carcinoid tumor with lymph node metastases: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Sakano Shigeru

    2009-01-01

    Full Text Available Abstract Background Carcinoid tumors are usually considered to have a low degree of malignancy and show slow progression. One of the factors indicating the malignancy of these tumors is their size, and small ampullary carcinoid tumors have been sometimes treated by endoscopic resection. Case presentation We report a case of a 63-year-old woman with a minute ampullary carcinoid tumor that was 7 mm in diameter, but was associated with 2 peripancreatic lymph node metastases. Mild elevation of liver enzymes was found at her regular medical check-up. Computed tomography (CT revealed a markedly dilated common bile duct (CBD and two enlarged peripancreatic lymph nodes. Endoscopy showed that the ampulla was slightly enlarged by a submucosal tumor. The biopsy specimen revealed tumor cells that showed monotonous proliferation suggestive of a carcinoid tumor. She underwent a pylorus-preserving whipple resection with lymph node dissection. The resected lesion was a small submucosal tumor (7 mm in diameter at the ampulla, with metastasis to 2 peripancreatic lymph nodes, and it was diagnosed as a malignant carcinoid tumor. Conclusion Recently there have been some reports of endoscopic ampullectomy for small carcinoid tumors. However, this case suggests that attention should be paid to the possibility of lymph node metastases as well as that of regional infiltration of the tumor even for minute ampullary carcinoid tumors to provide the best chance for cure.

  13. A morphological and molecular assessment of the genus Sinotubimorpha (Halymeniaceae, Rhodophyta)

    Institute of Scientific and Technical Information of China (English)

    Ying-Wen SHENG; Wen ZHANG; Dan ZHAO; Hong-Wei WANG

    2012-01-01

    A critical reassessment of the morphological features of two closely related red algal genera,Grateloupia C.Agardh and Sinotubimorpha W.X.Li & Z.F.Ding (Halymeniaceae),pointed out that members of the two genera had most morphological characteristics in common,including the Grateloupia type auxiliary cell ampullae.Sinotubimorpha hitherto was distinguished from Grateloupia by:(i) the hollow axis; (ii) the presence of secondary filaments in ampullae; (iii) 1- to 3-celled carpogonial branch; and (iv) the occasional production of 1- to 4-celled flanking filaments on carpogonium.However,when these features were re-examined among 37 Chinese species of genera described in Flora Algarum Marinarum Sinicarum and one newly reported species,Grateloupia orientalis,we found that it was difficult to draw a clear-cut distinction between the two genera based only on morphological differences.In rbcL sequence analysis,all the species of Sinotubimorpha with G.catenata formed a single monophyletic subclade within the large Grateloupia clade of the Halymeniaceae.It is therefore suggested that all the Chinese species of Sinotubimorpha,S.catenata,S.guangdongensis,S.qingdaoensis,S.claviformis,and S.ramosissima should be synonymous with G.catenata,and that Sinotubimorpha should be included in synonymy under Grateloupia.

  14. Expression and Localization of Ryanodine Receptors in the Frog Semicircular Canal

    Directory of Open Access Journals (Sweden)

    Paola Perin

    2012-01-01

    Full Text Available Several experiments suggest an important role for store-released Ca2+ in hair cell organs: drugs targeting IP3 and ryanodine (RyRs receptors affect release from hair cells, and stores are thought to be involved in vesicle recycling at ribbon synapses. In this work we investigated the semicircular canal distribution of RyRs by immunofluorescence, using slice preparations of the sensory epithelium (to distinguish cell types and flat mounts of the simpler nonsensory regions. RyRs were present in hair cells, mostly in supranuclear spots, but not in supporting cells; as regards nonsensory regions, they were also localized in dark cells and cells from the ductus. No labeling was found in nerve terminals, although nerve branches could be observed in proximity to hair cell RyR spots. The differential expression of RyR isoforms was studied by RT-PCR and immunoblotting, showing the presence of RyRα in both ampulla and canal arm and RyRβ in the ampulla only.

  15. Expression and localization of ryanodine receptors in the frog semicircular canal.

    Science.gov (United States)

    Perin, Paola; Botta, Laura; Tritto, Simona; Laforenza, Umberto

    2012-01-01

    Several experiments suggest an important role for store-released Ca²⁺ in hair cell organs: drugs targeting IP₃ and ryanodine (RyRs) receptors affect release from hair cells, and stores are thought to be involved in vesicle recycling at ribbon synapses. In this work we investigated the semicircular canal distribution of RyRs by immunofluorescence, using slice preparations of the sensory epithelium (to distinguish cell types) and flat mounts of the simpler nonsensory regions. RyRs were present in hair cells, mostly in supranuclear spots, but not in supporting cells; as regards nonsensory regions, they were also localized in dark cells and cells from the ductus. No labeling was found in nerve terminals, although nerve branches could be observed in proximity to hair cell RyR spots. The differential expression of RyR isoforms was studied by RT-PCR and immunoblotting, showing the presence of RyRα in both ampulla and canal arm and RyRβ in the ampulla only.

  16. The role of the accessory pancreatic duct of Santorini in pancreatic drainage in children (with emphasis on choledochal cyst patients)

    Energy Technology Data Exchange (ETDEWEB)

    Perisic, V.N.; Mihailovic, T.; Milovanovic, D. (Mother and Child Health Inst., Novi Beograd (Yugoslavia)); Tomomasa, T.; Kuroume, T. (Gunma Univ., Maebashi (Japan). Dept. of Pediatrics)

    1991-05-01

    Pancreatic drainage patterns have been studied by endoscopic retrograde cholangiopancreatography (ERCP) in four children with choledochal cyst (CC). The first two had mild or chemical pancreatitis; the third had a history of recurrent cholangitis and was diagnosed as chronic pancreatitis. The fourth manifested with severe, acute pancreatitis. All children were found to have an impaired flow through the papilla of Vater. In the first three cases, the duct of Santorini (DS) seemed to play an important role in the pancreatic drainage. In the fourth case, however, the duct was found to be absent. ERCP findings in additional eleven children without CC also were reviewed, and in this group the DS did not seem to play any significant role in pancreatic drainage. These results indicate that in children with common bile duct (CBD) anomalies, the DS may relieve the obstruction and ameliorate the pancreatitis. (orig.).

  17. Spondylo-costal dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Kozlowski, K.

    1984-02-01

    Fourteen patients with spondylo-costal dysplasia were analysed. 3 of them presented without obvious associated anomalies ''pure'' spondylo-costal dysplasias; 2 had several components consistent with Vater (Vacterl)-Association; 2 showed malformations which are often encountered in Vater (Vacterl)-Association; 4 presented with minor malformations; 3 had major associated malformations rarely seen in Vater (Vacterl)-Association. Thoracic spine and costal malsegmentation can be sporadically observed in other ''errors in septation complex'' (axial mesodermal dysplasia) including severe myelomeningocoele and diastematomyelia.

  18. En varice i vortexvenens ampul er en sjælden differentialdiagnose til malignt melanom i årehinden

    DEFF Research Database (Denmark)

    Rimsaite, Audrone; Andersen, Carl Uggerhøj

    2015-01-01

    Melanoma of the choroid is the most frequent primary intra-ocular malignancy whereas a varix of the vortex vein ampulla is a benign, rare and asymptomatic condition requiring no treatment. A varix of the vortex vein ampulla is usually found acci-dentally and can easily be mistaken for a choroidal...

  19. Akut pancreatitis forårsaget af galdesten i barnealderen

    DEFF Research Database (Denmark)

    Zachariassen, G; Saffar, D F; Mortensen, J

    1999-01-01

    A 10 year-old girl presented with acute abdominal pain. Serum-amylase was 3959 U/l. Ultrasonography showed dilatation of both the common bile duct and the pancreatic duct and a high density area near the ampulla. Endoscopic retrograde cholangiography (ERC) verified a stone near the ampulla, which...

  20. Pancreaticoduodenectomy for periampullary tumors at Dr. Cipto Mangunkusumo Hospital, Jakarta

    Directory of Open Access Journals (Sweden)

    Toar J.M. Lalisang

    2004-09-01

    Full Text Available We reported our experience on 31 pancreaticoduodenectomy out of 141 periampullary tumors during 1994 until 2002; 16 of them were female, and age average 17-68 years. Jaundice was the most common presenting sign; 14 patients showed plasma albumin lower than 3.5 g/dl, and 10 patients had bilirubin level more than 10 mg/dl. We performed classical Whipple technique in 17, pyloric preserving pancreaticoduodenectomy in 11, and total pancreaticoduodenectomy in 3 patients. The mean of operative time was 436 minutes (290-570 minutes. The patients were grouped into 2 periods, between 1994-1999 and thereafter. With experience, the amount of blood loss has decreased from 2000 ml to 400 ml. Histopathologic results showed adenocarcinoma of the pancreas head in 11, adenocarcinoma of the ampulla of Vater in 11, carcinoma of duodenum in 4, head of pancreas benign cyst in 2, and benign tumor in 3 patients. The surgical mortality was 4 in the first 12 patients, in contrast to only 1 in the last 19 patients. The most serious complication was pancreatic leakage in 14 patients, in 4 of them it was responsible as the cause of death. The length of stay after operation varied between 12 and 47 days. Until the end of this report 7 patients are still alive, and 4 patients lost of contact. Recurrence was detected in 13 out of 22 survivors, occurring between 4 to 24 months after operation and 12 patients died 2-3 months later. Three patients died due to other causes. We conclude that pancreoticoduodenectomy is an effective technique, and the operative mortality is decreasing. Furthermore, morbidity especially from pancreatic leakages can be treated in our hospital. (Med J Indones 2004; 13: 166-70 Keywords: operative outcome, Whipple technique, pancreatic leakage

  1. Endobronchial metastases from extrathoracic malignancies.

    Science.gov (United States)

    Akoglu, Sebahat; Uçan, Eyüp S; Celik, Gülperi; Sener, Gülper; Sevinç, Can; Kilinç, Oğuz; Itil, Oya

    2005-01-01

    Endobronchial metastases (EBM) from extrapulmonary malignant tumors are rare. The most common extrathoracic malignancies associated with EBM are breast, renal and colorectal carcinomas. In this study, we aimed to evaluate the clinical, radiographic and bronchoscopic aspects of patients with EBM who were diagnosed between 1992 and 2002. Data about patients' clinical conditions, symptoms, radiographic and endoscopic findings, and histopathological examination results were investigated. EBM was defined as bronchoscopically visible lesions histopathologically identical to the primary tumor in patients with extrapulmonary malignancies. We found 15 cases with EBM. Primary tumors included breast (3), colorectal (3), and renal (2) carcinomas; Malignant Melanoma (2); synovial sarcoma (1), ampulla of Vater adenocarcinoma (1), pheochromocytoma (1), hypernephroma (1), and Hodgkin's Disease (1). The most common symptoms were dyspnea (80%), cough (66.6%) and hemoptysis (33.3%). Multiple (40%) or single (13.3%) pulmonary nodules, mediastinal or hilar lymphadenopathy (40%), and effusion (40%) were the most common radiographic findings. The mean interval from initial diagnosis to diagnosis of EBM was 32.8 months (range, 0-96 months) and median survival time was 18 months (range, 4-84). As a conclusion, various extrapulmonary tumors can metastasize to the bronchus. Symptoms and radiographic findings are similar with those in primary lung cancer. Therefore, EBM should be discriminated from primary lung cancer histopathologically. Although mean survival time is usually short, long-term survivors were reported. Consequently, treatment must be planned according to the histology of the primary tumor, evidence of metastasis to other sites and medical status of the patient.

  2. Infiltration of local immune cells in the sow reproductive tracts after intra-uterine and deep intra-uterine insemination with a reduced number of spermatozoa is less than conventional artificial insemination.

    Science.gov (United States)

    Tummaruk, Padet; Tienthai, Paisan

    2011-05-01

    The present study investigated the infiltration of leukocyte subpopulations in the utero-tubal junction (UTJ) and each part of the oviducts at about 24 hr after intra-uterine insemination (IUI) and deep intra-uterine insemination (DIUI) compared to conventional artificial insemination (CAI) in sows. Fifteen crossbred Landrace x Yorkshire multiparous sows were used (CAI, n=5; IUI, n=5; DIUI, n=5). The sperm dose contained 3,000 × 10(6) (100 ml), 1,000 × 10(6) (50 ml) and 150 × 10(6) (5 ml) motile spermatozoa for CAI, IUI and DIUI, respectively. The sows were inseminated with extended fresh semen at 6 to 8 hr prior to the expected time of ovulation. At 25.2 ± 1.6 hr after insemination, the oviducts and the UTJ were collected. The tissue samples of UTJ, caudal isthmus, cranial isthmus and ampulla were transversely cut to a thickness of 5 µm and stained with H&E. The total numbers of lymphocytes, neutrophils, macrophages, eosinophils and plasma cells were determined under light microscope. It was found that the numbers of lymphocytes, eosinophils and macrophages after CAI, IUI and DIUI were not significantly different (P>0.1) in both epithelial and sub-epithelial connective tissue layer of the UTJ, caudal isthmus, cranial isthmus and ampulla. Intra-epithelial neutrophils in the UTJ were higher than cranial isthmus (P<0.05) and ampulla (P<0.05). In the UTJ, the intra-epithelial neutrophil in the CAI group was higher than DIUI group (P<0.01). Plasma cells in sub-epithelial layer of the endosalpinx in the CAI group were higher than DIUI group (P<0.05) and tended to be higher than the IUI group (P=0.08). In conclusion, compared to CAI, IUI and DIUI do not influence the infiltration of lymphocytes, macrophages and eosinophils in the UTJ and the oviduct prior to fertilization. But a lower number of neutrophils in the intra-epithelial layer of the UTJ and plasma cells in the sub-epithelial layers of the oviduct was observed in the DIUI group compared to CAI.

  3. Scanning electron microscopy of the vestibular end organs. [morphological indexes of inner ear anatomy and microstructure

    Science.gov (United States)

    Lindeman, H. H.; Ades, H. W.; West, R. W.

    1973-01-01

    The vestibular end organs, after chemical fixation, were freeze dried, coated with gold and palladium, and studied in the scanning microscope. Scanning microscopy gives a good three dimensional view of the sensory areas and allows study of both gross anatomy and microstructures. Cross anatomical features of the structure of the ampullae are demonstrated. The form of the statoconia in different species of animals is shown. New aspects of the structure of the sensory hairs are revealed. The hair bundles in the central areas of the cristae and in the striola of the maculae differ structurally from the hair bundles at the periphery of the sensory regions. Furthermore, some hair bundles consisting of very short stereocilia were observed. The relationship between the cupula and the statoconial membrane to the epithelial surface is discussed.

  4. Myoelectrical activity and transport of unfertilized ova in the oviduct of the mouse in vitro.

    Science.gov (United States)

    Talo, A

    1980-09-01

    The relationship of myoelectrical activity to locations and movements of eggs was analysed in 12 mouse oviducts in vitro. When the eggs were in the ampulla the ampullary activity did not spread through the ampullary-isthmic junction (AIJ), and a narrow region of activity of lower frequency separated the ampullary and isthmic activities. When the eggs were in the isthmus the activity beginning on the isthmic side of the AIJ spread towards the uterus for progressively longer distances. Eggs were near or at the front of the plateau formed by this activity. A separate activity arising in one or more areas of the uterine side of the plateau often spread in the ovarian direction, thus opposing movements of eggs and fluid in the uterine direction. Transport of unfertilized eggs appears to be regulated by a small number of relatively stable pacemakers in the mouse oviduct.

  5. The Smell of Relics: Authenticating Saintly Bones and the Role of Scent in the Sensory Experience of Medieval Christian Veneration

    Directory of Open Access Journals (Sweden)

    Paul Anthony Brazinski

    2013-09-01

    Full Text Available ''The archaeology of smell is a burgeoning field in recent scholarship. This paper adds to existing literature by investigating the function of smell in relation to relic sales and veneration in medieval Europe, a hitherto understudied area of research. Collating historical texts concerning the translatio of saintly relics in Western Europe and the Byzantine Empire with archaeological sources associated with relic veneration and religious worship (including ampullae, unguentaria, sarcophagi, holy oils, pillow graves, and silk, this paper suggests that (1 smell was used in the medieval world as a means to challenge or confirm a relic’s authenticity, and (2 olfactory liquids that imbued or permeated material objects in the context of worship functioned as a means of focusing attention on relic veneration and were an essential part of the cult and/or pilgrimage experience.

  6. Anatomy of Tunga trimamillata Pampiglione et al., 2002 (Insecta, Siphonaptera, Tungidae and developmental phases of the gravid female

    Directory of Open Access Journals (Sweden)

    Pampiglione S.

    2005-09-01

    Full Text Available This paper deals with some internal anatomical features observed in histological sections and freshly dissected mounts of Tunga trimamillata, a Siphonaptera recently discovered in Andean regions of Ecuador from several mammals, including man. It was possible to study in males and also non-gravid and gravid females, the location and anatomy of several organs not previously described for this species: the testes, epididymis, ganglia, Malpighian tubules, eyes, rectal ampulla with one of its pads and structures which could be interpreted as midgut diverticula, whose presence has not been recorded in the Siphonaptera. The process of neosomy in the female during pregnancy is illustrated by photographs of the consecutive developmental phases, taken at the stereomicroscope. Furthermore, some details of the exoskeleton, spermatheca during different phases of pregnancy of the gravid female and the presence of a foreign body (parasite? within the haemocoel have been displayed in specimens cleared with Hoyer’s medium.

  7. Vestibular tributaries to the vein of the vestibular aqueduct

    DEFF Research Database (Denmark)

    Hansen, Jesper Marsner; Qvortrup, Klaus; Friis, Morten

    2010-01-01

    CONCLUSION: The vein of the vestibular aqueduct drains blood from areas extensively lined by vestibular dark cells (VDCs). A possible involvement in the pathogenesis of an impaired endolymphatic homeostasis can be envisioned at the level of the dark cells area. OBJECTIVES: The aim of this study...... was to investigate the vascular relationship between the vein of the vestibular aqueduct and the vestibular apparatus, with focus on the VDCs. METHODS: Sixteen male Wistar rats were divided into groups of 6 and 10. In the first group, 2 µm thick sections including the vein of the vestibular aqueduct, utricle......, and crista ampullaris of the lateral ampulla were examined by light microscopy and computer-generated three-dimensional imaging. In the second group, ultrathin sections including venules and VDCs were examined by transmission electron microscopy. RESULTS: A microvascular network was observed in close...

  8. Immunolocalization of nerve growth factor (NGF) and its receptors (TrkA and p75LNGFR) in the reproductive organs of Shiba goats.

    Science.gov (United States)

    Ren, LongQuan; Medan, Mohamed S; Weng, Qiang; Jin, Wanzhu; Li, ChunMei; Watanabe, Gen; Taya, Kazuyoshi

    2005-06-01

    The objective of this study was to determine the immunolocalization of NGF and its receptors (TrkA and p75LNGFR) in the reproductive tract of the Japanese Shiba goats. Five adult goats were used in this study and sections of ovaries, uteri and oviducts were immunostained by the avidin-biotin-peroxidase complex method (ABC). The results showed that NGF and its receptors (TrkA and p75LNGFR) were expressed in granulosa cells, theca cells, interstitial cells and lutein cells in ovaries. Immunoreactions for NGF, TrkA and p75LNGFR were also detectable in epithelial cells and muscle cells of the ampulla and isthmus of the oviduct, and in epithelial cells and uterine glands of the uterus. These results strongly suggest autocrine and paracrine regulation of reproductive function by NGF in the reproductive tract of female Shiba goats.

  9. Immunolocalization of NGF and its receptors trkA and p75 in the oviducts of golden hamsters during the estrous cycle.

    Science.gov (United States)

    Weng, Qiang; Shi, ZhanQuan; Watanabe, Gen; Taya, Kazuyoshi

    2009-10-01

    To investigate the physiological roles of nerve growth factor (NGF) in the oviduct of golden hamsters during the estrous cycle, the localization of NGF and its receptors, trkA and p75, were determined by immunohistochemistry. Positive staining of NGF, trkA, and p75 was present in epithelial cells and muscle cells of the infundibulum, ampulla, and isthmus in the oviduct. The intensities of the immunohistochemical signals for NGF, trkA, and p75 did not markedly change in any segment of the oviduct during the estrous cycle. These results suggest that NGF may play autocrine/paracrine roles in oviductal transport, fertilization, capacitation of spermatozoa and early embryonic development in the oviduct of golden hamsters.

  10. Presentation and Surgical Management of Duodenal Duplication in Adults

    Directory of Open Access Journals (Sweden)

    Caroline C. Jadlowiec

    2015-01-01

    Full Text Available Duodenal duplications in adults are exceedingly rare and their diagnosis remains difficult as symptoms are largely nonspecific. Clinical presentations include pancreatitis, biliary obstruction, gastrointestinal bleeding from ectopic gastric mucosa, and malignancy. A case of duodenal duplication in a 59-year-old female is presented, and her treatment course is reviewed with description of combined surgical and endoscopic approach to repair, along with a review of historic and current recommendations for management. Traditionally, gastrointestinal duplications have been treated with surgical resection; however, for duodenal duplications, the anatomic proximity to the biliopancreatic ampulla makes surgical management challenging. Recently, advances in endoscopy have improved the clinical success of cystic intraluminal duodenal duplications. Despite these advances, surgical resection is still recommended for extraluminal tubular duplications although combined techniques may be necessary for long tubular duplications. For duodenal duplications, a combined approach of partial excision combined with mucosal stripping may offer advantage.

  11. Cupula motion in the semicircular canal of the skate, Raja erinacea. An experimental investigation.

    Science.gov (United States)

    Oman, C M; Frishkopf, L S; Goldstein, M H

    1979-01-01

    An upper bound on the magnitude of semicurcular canal cupula motion was experimentally determined in the isolated labyrinth of the skate, Raja erinacea. To visualize the cupula, a glass pipette was pushed through the ampullary wall, and local regions of the cupula were stained by slow infusion of small amounts of Alcian Blue dye. Caloric stimuli which produced large changes in single unit activity in the ampullary nerve and which often recruited several larger, previously silent units were found to produce on detectable cupula motion as seen through the ampulla wall. However when the cupula was first grossly displaced, motion was thereafter observed in response to identical caloric stimuli. Analysis of afferent responses indicates that the normal range of cupula motion in the skate is below the optical resolution of the method, conservatively estimated as 3--5 micrometers.

  12. Sylphellapuccoon gen. n., sp. n. and two additional new species of aquatic oligochaetes (Lumbriculidae, Clitellata) from poorly-known lotic habitats in North Carolina (USA).

    Science.gov (United States)

    Rodriguez, Pilar; Fend, Steven V; Lenat, David R

    2014-01-01

    Three new species of Lumbriculidae were collected from floodplain seeps and small streams in southeastern North America. Some of these habitats are naturally acidic. Sylphellapuccoon gen. n., sp. n. has prosoporous male ducts in X-XI, and spermathecae in XII-XIII. Muscular, spherical atrial ampullae and acuminate penial sheaths distinguish this monotypic new genus from other lumbriculid genera having similar arrangements of reproductive organs. Cookidriluspocosinus sp. n. resembles its two subterranean, Palearctic congeners in the arrangement of reproductive organs, but is easily distinguished by the position of the spermathecal pores in front of the chaetae in X-XIII. Stylodriluscoreyi sp. n. differs from congeners having simple-pointed chaetae and elongate atria primarily by the structure of the male duct and the large clusters of prostate cells. Streams and wetlands of Southeastern USA have a remarkably high diversity of endemic lumbriculids, and these poorly-known invertebrates should be considered in conservation efforts.

  13. Sylphella puccoon gen. n., sp. n. and two additional new species of aquatic oligochaetes (Lumbriculidae, Clitellata from poorly-known lotic habitats in North Carolina (USA

    Directory of Open Access Journals (Sweden)

    Pilar Rodriguez

    2014-11-01

    Full Text Available Three new species of Lumbriculidae were collected from floodplain seeps and small streams in southeastern North America. Some of these habitats are naturally acidic. Sylphella puccoon gen. n., sp. n. has prosoporous male ducts in X–XI, and spermathecae in XII–XIII. Muscular, spherical atrial ampullae and acuminate penial sheaths distinguish this monotypic new genus from other lumbriculid genera having similar arrangements of reproductive organs. Cookidrilus pocosinus sp. n. resembles its two subterranean, Palearctic congeners in the arrangement of reproductive organs, but is easily distinguished by the position of the spermathecal pores in front of the chaetae in X–XIII. Stylodrilus coreyi sp. n. differs from congeners having simple-pointed chaetae and elongate atria primarily by the structure of the male duct and the large clusters of prostate cells. Streams and wetlands of Southeastern USA have a remarkably high diversity of endemic lumbriculids, and these poorly-known invertebrates should be considered in conservation efforts.

  14. Mathematical Model of the Cupula-Endolymph System with Morphological Parameters for the Axolotl (Ambystoma tigrinum) Semicircular Canals.

    Science.gov (United States)

    Vega, Rosario; Alexandrov, Vladimir V; Alexandrova, Tamara B; Soto, Enrique

    2008-08-26

    By combining mathematical methods with the morphological analysis of the semicircular canals of the axolotl (Ambystoma tigrinum), a system of differential equations describing the mechanical coupling in the semicircular canals was obtained. The coefficients of this system have an explicit physiological meaning that allows for the introduction of morphological and dynamical parameters directly into the differential equations. The cupula of the semicircular canals was modeled both as a piston and as a membrane (diaphragm like), and the duct canals as toroids with two main regions: i) the semicircular canal duct and, ii) a larger diameter region corresponding to the ampulla and the utricle. The endolymph motion was described by the Navier-Stokes equations. The analysis of the model demonstrated that cupular behavior dynamics under periodic stimulation is equivalent in both the piston and the membrane cupular models, thus a general model in which the detailed cupular structure is not relevant was derived.

  15. Three-dimensional modeling of a patent ductus arteriosus in a cat.

    Science.gov (United States)

    Saunders, A B; Birch, S A

    2015-12-01

    A left-to-right shunting patent ductus arteriosus was diagnosed in a 13-week-old, 2.5 kg, male, domestic Shorthair cat with a continuous murmur. Echocardiographic abnormalities were identified, including: cardiomegaly, wide and presumably short ductal ampulla, and a large right branch pulmonary artery. When these findings were combined with the small patient size, additional imaging was considered prior to surgical ligation, and computed tomography angiography was preferred over standard angiography to provide multi-dimensional appreciation of the anatomy prior to surgery. The dataset from a computed tomography angiographic study performed prior to surgical ligation was used to create a three-dimensional model of the heart and great vessels. The rendered images accurately depicted the cardiac anatomy in situ, which can be utilized for surgical procedural planning and to enhance visuospatial understanding of the anatomy at all levels of training.

  16. Detection of the matrix metalloproteinases MMP-2 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 in llama (Lama glama) oviduct.

    Science.gov (United States)

    Zampini, R; Argañaraz, M E; Miceli, D C; Apichela, S A

    2014-06-01

    Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are involved in several reproductive events like oocyte-spermatozoa interaction and semen liquefaction. In order to study their role in the llama oviductal reproductive process, MMP activity in oviductal fluid (OF) was assayed. Considering that llama genome sequences are partially known, a strategy to procure cDNA sequences of MMP-2, MMP-9, TIMP-1 and TIMP-2 was designed. Afterwards, their expression patterns in the different llama oviductal segments were assayed. Gelatine zymograms detected 62 and 94 kDa protease activities that matched MMP-2 and pro-MMP-9, respectively. Expression pattern analysis showed that MMP and TIMP mRNAs were present in ampulla, isthmus, utero-tubal junction (UTJ) and papilla. Altogether, these findings support the argument that MMPs/TIMPs are produced in the oviduct and secreted into the oviductal lumen. Our results encourage further studies to elucidate the role of these proteins in reproductive oviductal events.

  17. En varice i vortexvenens ampul er en sjælden differentialdiagnose til malignt melanom i årehinden

    DEFF Research Database (Denmark)

    Rimsaite, Audrone; Andersen, Carl Uggerhøj

    2015-01-01

    Melanoma of the choroid is the most frequent primary intra-ocular malignancy whereas a varix of the vortex vein ampulla is a benign, rare and asymptomatic condition requiring no treatment. A varix of the vortex vein ampulla is usually found acci-dentally and can easily be mistaken for a choroidal...... melanoma, a naevus or a haemorrhage. We present a case of a varix of the vortex vein ampulla, which can be distinguished from other more serious conditions by using simple clinical methods....

  18. Transport of ova transferred to rabbit oviducts at varying intervals after human chorionic gonadotropin injection.

    Science.gov (United States)

    Weinberg, L; Pauerstein, C J

    1980-01-01

    Ova obtained from donors were transfered to the oviducts of New Zealand White rabbits at various times after injection of human chorionic gonadotropin. The rabbits were killed at varying intervals after transfer. The genital tracts were removed, divided into segments (ampulla, isthmus, uterus, and vagina), and flushed to recover the ova. The experiments demonstrated the following: (1) A mechanism is present that retains some of the transferred ova above the ampullary-isthmic junction (AIJ). This mechanism is most efficient 60 hours after hCG injection. (2) Transferred ova that succeed in negotiating the AIJ are found in locations appropriate to the time elapsed from ovulation, rather than from transfer; i.e., they "catch up" to the endogenous ova.

  19. Co-Speciation of Earthworms and their nephridial symbionts, Acidovorax Spp

    DEFF Research Database (Denmark)

    Lund, Marie Braad; Fritz, Michael; Holmstrup, Martin

    2006-01-01

    the extracted DNA. The presence of the symbionts in the ampulla was verified by performing fluorescence in situ hybridization (FISH) on all worm species using an Acidovorax-specific probe. Earthworm and symbiont phylogeny was largely congruent, indicating that host and symbiont have indeed co-evolved since...... within the genus Acidovorax [2], and they are transmitted vertically [3]. For these reasons, we suggest that the earthworm-Acidovorax association has evolved by co-speciation. This hypothesis was tested by a comparative study of earthworm and symbiont phylogeny. Different earthworm species were collected...... in Denmark and DNA was extracted from their nephridia. Earthworm phylogeny was resolved on the basis of mitochondrial cytochrome c oxidase subunit I (COI) by direct PCR amplification and sequencing from the nephridial DNA extract. Symbiont 16S rRNA gene sequences were retrieved by cloning and sequencing...

  20. Sperm head binding to epithelium of the oviduct isthmus is not an essential preliminary to mammalian fertilization - review.

    Science.gov (United States)

    Hunter, R H F

    2011-08-01

    In endeavouring to understand the nature of sperm-oviduct interactions in mammals, attention was focused on experimental models in which fertilization can occur without a preliminary phase of sperm head binding to the isthmus epithelium. The ovarian endocrine milieu imposed on the oviduct tissues plays an important role in the binding phenomenon, although less so after the time of ovulation. Nonetheless, a sperm suspension introduced into the peritoneal cavity or surgical insemination directly into the oviduct ampulla before ovulation can result in fertilization, as can a surgical model in which the isthmus has been resected and the remaining portions of the duct reanastomosed. Mating or artificial insemination after ovulation in pigs permits rapid sperm transport to the site of fertilization, and the frequency of polyspermic penetration increases with the post-ovulatory age of eggs.Strategies underlying sperm binding were considered, especially in terms of preovulatory sperm storage and suppression of full membranous maturation. These, in turn, raised the problem of how sperm binding in vitro to oviduct cells from prepuberal animals or to cells harvested during the luteal phase of the estrous cycle, or to cells from the ampulla or even the tracheal epithelium, can act to regulate sperm storage and maturation with precision. In an evolutionary perspective, preovulatory binding of diverse populations of cells to the endosalpinx may have developed as a form of fine tuning to assist in sperm selection, to synchronize completion of capacitation with the events of ovulation, and to promote monospermic fertilization by a controlled release of competent gametes.

  1. In vitro assessment of some sperm function following exposure to levonorgestrel in human fallopian tubes

    Directory of Open Access Journals (Sweden)

    Hermanny Alexia

    2012-01-01

    Full Text Available Abstract Background The mechanism of action of levonorgestrel (LNG as emergency contraception (EC remains a subject of debate and its effect on sperm function has been only partially explained. The aim of this study was to assess whether LNG at a similar dose to those found in serum following oral intake for EC could affect spermatozoa when exposed to human fallopian tubes in vitro. Methods Fifteen mini-laparotomies were performed, the side on which ovulation occurred was recorded, and both tubes were removed and perfused with a suspension containing 1 × 10(6 motile spermatozoa, with or without LNG. Following 4-hour incubation, the tubes were sectioned to separate the isthmus and the ampulla. Each segment was flushed and the material was evaluated to quantify the number of motile sperm, the number of spermatozoa adhering to the oviductal epithelium and the acrosome reaction (AR rate. Results The addition of LNG did not significantly alter the number of recovered motile spermatozoa either at the isthmus or at the ampulla, nor did it have any effect on the number of recovered spermatozoa adhered to the human tubal epithelium. Furthermore, LNG did not affect the AR rate. No significant differences were found even when the side on which ovulation occurred was taken into account. Conclusions In a similar dose to that observed in serum following oral intake for EC, LNG had no effect on the number of motile spermatozoa recovered from the human fallopian tubes in vitro, on their adhesion to the tubal epithelium, distribution or AR rate. The possible effect of LNG as EC on sperm function remains poorly understood.

  2. Concentrations and contractile effects of substance P in the human ampullary-isthmic junction.

    Science.gov (United States)

    Forman, A; Andersson, K E; Maigaard, S; Ulmsten, U

    1985-05-01

    From 20 women undergoing hysterectomy, strip preparations were isolated from the outer, longitudinal and the inner, circular smooth muscle layer of the ampullary-isthmic junction (AIJ), together with small arterial segments dissected as ring preparations from the root of the mesosalpinx. The specimens were mounted in organ baths and isometric tension was recorded. In addition, tissue concentrations of substance P (SP) in the ampulla, AIJ and utero-tubal junction were determined by radioimmunoassay. Tissue concentrations of SP expressed as pmol X g tissue-1 (wet weight, +/- SE) amounted to 3.09 +/- 1.40 in the utero-tubal junction, 1.08 +/- 0.299 in the AIJ and 0.742 +/- 0.299 in the ampulla. In strips of circular muscle, SP at concentrations of 10(-7) -3 X 10(-6) mol X l-1 elicited a combined phasic and tonic response and in longitudinal muscle a mainly tonic contraction was produced. In both tissues, contractions elicited by SP were rapidly abolished in calcium-free medium. Nifedipine abolished the phasic contraction elicited in circular muscle by SP while the tonic response was resistant. The contraction in longitudinal muscle was reduced by 20-30%. Vasoactive intestinal polypeptide (VIP) decreased tension in preparations contracted by SP, prostaglandin F2 alpha and K+-depolarization (124 mmol X l(-1). In unstimulated oviductal arterial preparations, SP had no effect, while the peptide induced a transient relaxation of noradrenaline contracted preparations, and slightly decreased tension of K+-depolarized vessels. The results suggest that SP may be involved in the control of motility of the human AIJ.

  3. Endoscopic Ultrasound (EUS)-Guided Pancreatic Duct Drainage: The Basics of When and How to Perform EUS-Guided Pancreatic Duct Interventions

    Science.gov (United States)

    Chapman, Christopher G.; Waxman, Irving; Siddiqui, Uzma D.

    2016-01-01

    Despite the advances in endoscopy, endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD) remains a technically challenging procedure. Technical success rates are greater than 70%; however, the average rate of adverse events is nearly 20%, which increases to 55% when stent migration is included. Until recently, a significant difficulty with this technique was the absence of dedicated devices. Proper patient selection is of utmost importance, and EUS-PDD should be reserved for patients who have failed endoscopic retrograde pancreatography. Furthermore, EUS-PDD must be performed by experienced endoscopists who are familiar with the technique. The most common indications include chronic pancreatitis induced strictures and stones, disconnected pancreatic ducts, inaccessible ampulla, and post-surgical altered anatomy. This manuscript will review the accessories used, techniques employed, and published literature reporting outcomes as well as adverse events regarding EUS-PDD. PMID:27012290

  4. Trinocladus divnae and montiella filipovici: A new species (Dasycladales, green algae from the Upper Cretaceous of the Mountain Paštrik (Mirdita Zone

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    Radoičić Rajka

    2006-01-01

    Full Text Available Two new dasycladalean species from the Upper Cretaceous of the Mountain Paštrik, Kukes Cretaceous Unit of the Mirdita Zone are described: Trinocladus divnae sp. nov. is characterized by variable size of the thallus, relatively narrow main axis, typical Trinocladus organization of the laterals and thin calcification limited to the distal part of the thallus which includes a swollen part of secondaries and short tertiaries. Often, the internal portion of the whorls (except sometimes the main stem membrane, tends to dissolve and form dissolution cavities filled with cement. Montiella filipovici sp. nov. is characterized by a primary skeleton made of a thin individual sheath around a fertile ampullae, often obliterated by recrystallization. Four to six laterals, each giving one secondary and one fertile ampulla located on the upper side of the relatively thick short primary lateral. Upper Cenomanian limestone with Cisalveolina fraasi and Trinocladus divnae sp. nov. was deposited immediately before the events that resulted in sea level rising. The middle and upper Cenomanian eustatic-tectonic processes had different effects in the Paštrik shallow water areas, depending on the distance from the basinal part of the Unit. Bathymetric changes in a part of the Paštrik sedimentary area were not significant, even negligible. Montiella filipovici is found in the post-fraasi shallow water sequence, assigned to the ?uppermost Cenomanian-lowermost Turonian (= Whiteinella archaeocretacea Zone p. p.; a short stratigraphic gap, in a part of the area, is noted. Shallow water limestone with Turonian taxa, corresponding to the helvetca Zone, occurs a few meters upward. Supplementary note: the species Cylindroporella parva RADOIČIĆ is transferred in the genus Montiella, the species Permocalculus elliotti JOHNSON is transferred in the genus Trinocladus, while the species Trinocladus bellus YU JING is transferred in the genus Belzungia.

  5. Operational Management and Complication Prevention of Laparoscopic Cholecystectomy for Gangrenous Cholecystitis Caused by Incarcerated Gallstones:Report of 36 Cases%结石嵌顿坏疽性胆囊炎腹腔镜手术处理与并发症预防(附36例报告)

    Institute of Scientific and Technical Information of China (English)

    秦建民; 倪雷; 赵威; 张敏; 陈诚; 潘刚; 陈腾

    2015-01-01

    Objective To explore the operational management and complication prevention of laparoscopic cholecystectomy for gangrenous cholecystitis caused by incarcerated gallstones . Methods Laparoscopic cholecystectomy was urgently performed in 36 patients with gangrenous cholecystitis caused by incarcerated gallstones .The puncture was performed to decompress the gallbladder at the bottom of the gallbladder in order to reveal the gallbladder ampulla .The gallbladder wall was opened to take out stones when the gallbladder ampulla could not be revealed after decompression .The front and rear gallbladder triangles were bluntly dissected adjacent to the gallbladder ampulla to reveal the cystic duct .Then the cystic duct was clipped and cut off near the gallbladder ampulla .The cystic duct was closed with 4-0 absorbed stitches or left open with residual gallbladder mucosa in the gallbladder neck . Results Laparoscopic cholecystectomy was performed in 35 patients, with a conversion to open cholecystectomy performed in 1 patient.The operation time was 45-150 min, with a mean of 55 min.The mean intraoperative blood loss was 80 ml (range, 50-250 ml).The hospital stay was 3 -10 d, with a mean of 4.5 d.The bile leakage occurred in 1 patient after operation , which was cured with conservative treatment .There were no complications such as abdominal bleeding or infection in all the patients .A total of 31 patients were followed up for 6-18 months ( mean, 11 months ) .No abdominal pain , jaundice , bile duct stricture , or secondary bile duct calculus occurred in all the patients . Conclusion It is crucial in laparoscopic cholecystectomy for gangrenous cholecystitis caused by incarcerated gallstones that preoperative imaging examination , fine intraoperative performance , and rational management are emphasized.%目的:探讨结石嵌顿坏疽性胆囊炎腹腔镜胆囊切除术的技巧与并发症预防。方法2009年6月~2014年6月急诊LC治疗结石嵌顿坏疽性胆囊炎36

  6. Natriuretic peptide type C induces sperm attraction for fertilization in mouse

    Science.gov (United States)

    Kong, Nana; Xu, Xiaoting; Zhang, Yu; Wang, Yakun; Hao, Xiaoqiong; Zhao, Yu; Qiao, Jie; Xia, Guoliang; Zhang, Meijia

    2017-01-01

    Mammalian spermatozoa undergo selective movement along the isthmus of the oviduct to the ampulla during ovulation, which is a prerequisite for fertilization. The factor(s) that involves in selective spermatozoa movement is still unknown. In this study, we found that the oviductal epithelium in mouse ampulla expressed high levels of natriuretic peptide type C (NPPC) in the presence of ovulated oocyte-cumulus complexes (OCCs). Spermatozoa expressed NPPC receptor natriuretic peptide receptor 2 (NPR2, a guanylyl cyclase) on the midpiece of flagellum. NPPC increased intracellular levels of cGMP and Ca2+ of spermatozoa, and induced sperm accumulation in the capillary by attraction. Importantly, spermatozoa from Npr2 mutant mice were not attracted by NPPC, preventing fertilization in vivo. Oocyte-derived paracrine factors promoted the expression of Nppc mRNA in the ampulla. Therefore, NPPC secreted by oviductal ampulla attracts spermatozoa towards oocytes, which is essential for fertilization. PMID:28054671

  7. Identificação trans-operatória do óstio do Wirsung após a papilo-esfincterotomia Intra-operatory identification of the ostium of Wirsung's pancreatic duct after sphincterotomy

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    A.L. da Silva

    1999-04-01

    Full Text Available OBJETIVO: Contribuir para o achado do óstio de Wirsung durante a técnica da papilo-esfincteroplastia, prevenindo a pancreatite aguda pós-operatória. CASUÍSTICA E MÉTODO: Foram estudados 27 pacientes submetidos a papilo-esfincteroplastia por coledocolitíase com ou sem odite. Após a papilo-esfincterotomia (PET terapêutica, por via duodenal, realizou-se estudo da localização do óstio do ducto de Wirsung. A PET transforma a ampola de Vater em um triângulo isósceles, cujas medidas foram obtidas através de compasso. Utilizando-as, o óstio do Wirsung poderá ser facilmente identificado e cateterizado no trans-operatório, antes de se fazer a sutura muco-mucosa da papila seccionada. RESULTADOS: O óstio geralmente é encontrado medialmente na metade esquerda do triângulo e a uma distância média de 0,19cm a 0,25cm acima da base do triângulo, considerando-se a ausência ou presença de inflamação, respectivamente. CONCLUSÃO: A determinação transoperatória das distâncias padronizadas neste estudo, permite a detecção e cateterização segura do óstio do Wirsung na presença ou não de odite.PURPOSE: The aim of this study is to suggest a feasible method to find the ostium of the Wirsung's duct during sphincteroplasty of the Vater's papilla, in order to avoid post-operative complications such as acute pancreatitis. PATIENTS AND METHODS: A total of 27 patients were submitted to sphincteroplasty for choledocolithiasis with or without Odditis. After therapeutic papillotomy and sphincterotomy through the duodenun, the location of the ostium of the Wirsung's duct was determined and studied. After papillotomy, the Vater's papilla becomes an isosceles triangle and its measurements were made with a compass. Thereby the ostium of Wirsung's duct was easily detected and a catheter was inserted before the suture of the mucosa of the papilla. RESULTS: The ostium was generally found medially, on the left side of the triangle, 0.19cm to 0.25cm

  8. No Stone Left Unturned: Using Choledocholithiasis to Open a Papillary Stenosis via a Choledochodudenal Fistula.

    Science.gov (United States)

    West, Sara; Shellenberger, M Joshua

    2016-01-01

    In a patient found to have cholelithiasis and choledocholithiasis, a choledochoduodenal fistula was used to gain access to the bile duct. Due to severe stenosis and atrophy of the major papilla, cannulation was not possible. Stones were purposely impacted in the native ampulla to cause bulging and stretching of the stenosis. Once the stenosis was stretched, the bile and pancreatic duct were accessed via the native ampulla, allowing for stone removal.

  9. No Stone Left Unturned: Using Choledocholithiasis to Open a Papillary Stenosis via a Choledochodudenal Fistula

    OpenAIRE

    West, Sara; Shellenberger, M. Joshua

    2016-01-01

    In a patient found to have cholelithiasis and choledocholithiasis, a choledochoduodenal fistula was used to gain access to the bile duct. Due to severe stenosis and atrophy of the major papilla, cannulation was not possible. Stones were purposely impacted in the native ampulla to cause bulging and stretching of the stenosis. Once the stenosis was stretched, the bile and pancreatic duct were accessed via the native ampulla, allowing for stone removal.

  10. [German-Hungarian medical relationships during the Enlightenment; including an 18th century work on inoculation against plague].

    Science.gov (United States)

    Schultheisz, E

    2001-09-01

    The influence of German science and medicine on the development of Hungarian medicine in the age of Enlightenment has been extraordinary strong. Many Hungarian medical students stayed in German medical faculties. The medical interrelationships between Germany and Hungary in the 18th century are discussed in an overview according to the following dimensions: education of protestant Hungarian medical students at German >Aufklaerungs-Universitaeten<, practical and theoretical resonance, membership of scientific societies, personal contacts and correspondence. Outstanding personalities of this area were Daniel Fischer, István Weszprémi, Abraham Vater. Special attention is given to a new idea: inoculation against plague was first described by A. Vater in his work Blattern-Beltzen (1721). Thirty years later I. Weszprémi published his original conception - independently from Vater - in the Tentamen de inoculanda peste (1755).

  11. Ultrasound-guided percutaneous transhepatic biliary drainage: Experiences in 146 patients

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jai Keun [Sohwa Children' s Hospital, Seoul(Korea, Republic of); Yu, Jeong Sik; Kim, Ki Whang; Chung, Soo Yoon; Jeong, Mi Gyoung [Yonsei University College of Medicine, Seoul (Korea, Republic of); Choi, Deuk Lin; Kwon, Gui Hyang; Lee, Hae Kyung [Soonchunhyang University College of Medicine, Seoul (Korea, Republic of)

    1999-03-15

    Percutaneous biliary drainage is an important technique for palliative therapy of obstructive biliary disease and diagnostic information. The purpose of this study is to review and evaluate the experiences of ultrasound-guided percutaneous transhepatic biliary drainage. Ultrasound-guided percutaneous transhepatic biliary drainage was performed on 146 occasions in 134 patients. The causes of biliary obstruction were: benign diseases (19 cases, 14.2%) such as bile duct stones or stricture, cholangiocarcinoma (37 cases, 27.6%), pancreatic carcinoma (35 cases, 26.1%), metastasis (22 cases, 16.5%), gall bladder cancer (14 cases, 10.4%), ampulla of Vater cancer (4 cases, 3.0%), hepatocellular carcinoma (3 cases, 2.2%). Retrospectively reviewing medical records, we found out frequency of external or external/internal biliary drainages, puncture of left or right hepatic duct, and presence of bileinfection. Ultrasound-guided percutaneous transhepatic biliary drainage was compared with conventional biliary drainage of previous reports on the basis of frequency of complications. External (124 procedures, 84.9%) and external/internal biliary drainage (22 procedures, 15.1%) were carried out by puncture of dilated right (59.6%) or left (40.4%) intrahepatic duct. Sixty-nine complications occurred in 47 patients. Catheter related complications (33/69, 47.8%) were most common: catheter dislodgement (17/69, 24.6%), malfunction (9/69, 13.1%), leakage (7/69, 10.1%). Other minor complications such as simple fever (16/69, 23.2%), cholangitis (7/69, 10.1%), hemobilia (4/69, 5.8%), biloma (2/69, 2.9%) and wound infection (1/69, 1.5%) occurred. Major complications including sepsis (4/69, 5.8%) and bile peritonitis (2/69, 2.9%) were also noted. Puncture-related complications such as hemobilia, biloma and bile peritonitis occurred in 8 cases (5.5%). Comparing with conventional X-ray guided drainage, ultrasound-guided percutaneous transhepatic biliary drainage is a safe procedure for

  12. Association between alcohol consumption and cancers in the Chinese population--a systematic review and meta-analysis.

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    Ying Li

    Full Text Available BACKGROUND: Alcohol consumption is increasing worldwide and is associated with numerous cancers. This systematic review examined the role of alcohol in the incidence of cancer in the Chinese population. METHODS: Medline/PubMed, EMBASE, CNKI and VIP were searched to identify relevant studies. Cohort and case-control studies on the effect of alcohol use on cancers in Chinese were included. Study quality was evaluated using the Newcastle-Ottawa Scale. Data were independently abstracted by two reviewers. Odds ratios (OR or relative risks (RR were pooled using RevMan 5.0. Heterogeneity was evaluated using the Q test and I-squared statistic. P<.01 was considered statistically significant. RESULTS: Pooled results from cohort studies indicated that alcohol consumption was not associated with gastric cancer, esophageal cancers (EC or lung cancer. Meta-analysis of case-control studies showed that alcohol consumption was a significant risk factor for five cancers; the pooled ORs were 1.79 (99% CI, 1.47-2.17 EC, 1.40 (99% CI, 1.19-1.64 gastric cancer, 1.56 (99% CI, 1.16-2.09 hepatocellular carcinoma, 1.21 (99% CI, 1.00-1.46 nasopharyngeal cancer and 1.71 (99% CI, 1.20-2.44 oral cancer. Pooled ORs of the case-control studies showed that alcohol consumption was protective for female breast cancer and gallbladder cancer: OR 0.76 (99% CI, 0.60-0.97 and 0.70 (99% CI, 0.49-1.00 respectively. There was no significant correlation between alcohol consumption and lung cancer, colorectal cancer, pancreatic cancer, cancer of the ampulla of Vater, prostate cancer or extrahepatic cholangiocarcinoma. Combined results of case-control and cohort studies showed that alcohol consumption was associated with 1.78- and 1.40-fold higher risks of EC and gastric cancer but was not significantly associated with lung cancer. CONCLUSIONS: Health programs focused on limiting alcohol intake may be important for cancer control in China. Further studies are needed to examine the

  13. The role of magnetic resonance cholangiopancreatography (MRCP) in choledocholithiasis

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Yukinao; Nishikawa, Kunihisa; Ohtaki, Tetsuo; Hata, Masanori; Miyaji, Hideki; Hayashi, Shigeyuki [Fukui Red Cross Hospital (Japan)

    2001-07-01

    Recently, magnetic resonance cholangiopancreatography (MRCP) has been widely used in the clinical field as a noninvasive method to visualize the main pancreatic duct and the biliary system. We evaluated the accuracy of MRCP, abdominal CT and abdominal urtrasonography in the diagnosis of choledocholithiasis in comparison with that of endoscopic retrograde cholangiopancreatography (ERCP). Forty patients with choledocholithiasis with some complications, such as icterus, pancreatitis or cholangitis, were examined by MRCP, CT, US and ERCP. We studied the detection rate of the common bile duct stones in MRCP, CT, US separately, and the diagnostic value of each of the other techniques was compared with that of ERCP. The detection rate of common bile duct stones in MRCP, CT and US was 87.5%, 80.5% and 45.0%, respectively. The combined detection rate in MRCP and CT, MRCP and US, CT and US, and MRCP, CT and US was 95.0%, 97.5%, 80.0% and 100%, respectively. MRCP could not efficiently detect common bile duct stones less than 5 mm in size. Moreover, it was impossible to detect impacted stones in the papilla of Vater by MRCP. Currently, it would seem that the combination of MRCP, CT and US has comparable efficacy for the diagnosis of common bile duct stones in patients with the complications to that of ERCP. (author)

  14. ["For me, painting is a continuation of dreaming by different means" (Neo Rauch 2006). Contributions of art to psychoanalytic dream interpretation].

    Science.gov (United States)

    Danckwardt, Joachim F

    2008-01-01

    This paper maintains that pictorial and scenic thinking (represented in dreams, daydreams, paintings, pictorial language) is not a regressive phenomenon usurping ego energy. It is rather a kind of thinking with eyes, hands and feet resp. with formative means such as point, line, plane, space, movement, color, and contrast which constitute consciousness from the ocean of the inner and outer unconscious. This is shown by discussing the painting "Vater [Father]" (2007) of Neo Rauch as well as the views of, among others, Kandinsky, Klee, and Rothko. Rauch's notion of painting as a continuation of dreaming is confirmed by a re-analysis of Freud's dream of the "castle by the sea". Here dream-work is similar to picture and film work. The choice of formative means determines whether pictures will be born or something else: a dream, fantasy, idea or interpretation, and by the same token it determines the kind of picture, dream, fantasy etc. Freud's dream of the "castle by the sea" is a "specimen dream" for interpretation via retranslation of picture/dream-work.

  15. [A Case of Invasive Intraductal Papillary Mucinous Carcinoma, Penetrating the Stomach, Colon, and Jejunum].

    Science.gov (United States)

    Goto, Tadahiro; Toyama, Hirochika; Asari, Sadaki; Terai, Sachio; Kinoshita, Hisoka; Matsumoto, Taku; Kuramitsu, Kaori; Tanaka, Motofumi; Takebe, Atsushi; Kido, Masahiro; Matsumoto, Ippei; Ajiki, Tetsuo; Fukumoto, Takumi; Ku, Yonson

    2015-11-01

    A 69-year-old woman was admitted to a nearby clinic complaining of abdominal pain. Abdominal CT showed a 10 cm diameter huge cystic lesion in the body and tail of the pancreas. The patient was referred to our institution for treatment. Endoscopic ultrasonography (EUS) revealed a cystic mass with a solid lesion. Endoscopic retrograde pancreatography(ERP) demonstrated mucous at the opening of the papilla of Vater and dilatation of the pancreatic duct with a solid nodule. Contrast radiography revealed a fistula from the tumor to the jejunum. A biopsy specimen from the lesion showed adenocarcinoma. Intraoperative findings showed a tumor occupying the pancreas body and tail with suspected invasion to the stomach, jejunum, and transverse colon. We performed distal pancreatectomy with partial resection of stomach, jejunum, and colon. Pathological findings showed an invasive type of IPMC, with invasion to the subserosal layer of the stomach and colon and the mucous layer of the jejunum. While IPMC is recognized as a slow growing malignancy, some cases of invasive carcinoma with fistulation into adjacent organs have been reported. To our knowledge, a case of IPMC penetrating to 3 adjacent organs is rare.

  16. A case of methicillin-resistant Staphylococcus aureus infection following bile duct stenting

    Institute of Scientific and Technical Information of China (English)

    Markus K Diener; Alexis Ulrich; Theresia Weber; Moritz N Wente; Markus W Büchler; Helmut Friess

    2005-01-01

    AIM: To present a case of methicillin-resistant Staphylococcus aureus (MRSA) infection following bile duct stenting in a patient with malignant biliary obstruction.METHODS: A 78-year-old male patient was admitted to a community hospital with progredient painless jaundice lasting over two weeks, weight loss and sweating at night.Whether a stent should be implanted pre-operatively in jaundiced patients or whether these patients should directly undergo surgical resection, was discussed.RESULTS: ERC and a biopsy from the papilla of Vater revealed an adenocarcinoma. In addition, a 7-Ch plastic stent was placed into the common bile duct. Persistent abdominal pain, increasing jaundice, weakness and indigestion led to the transfer of the patient to our hospital.A pylorus-preserving pancreatoduodenectomy wasperformed. Intraoperatively, bile leaked out of the transected choledochus andthe stent was found to be dislocated in the duodenum. A smear of the bile revealed an infection with MRSA, leading to post-operative isolation of the patient.CONCLUSION:As biliary stents can cause severe infection of the bile, the need for pre-operative placement of biliary stents should be carefully evaluated in each individual case.

  17. Mucin-hypersecreting bile duct neoplasm characterized by clinicopathological resemblance to intraductal papillary mucinous neoplasm (IPMN of the pancreas

    Directory of Open Access Journals (Sweden)

    Harimoto Norifumi

    2007-08-01

    Full Text Available Abstract Background Although intraductal papillary mucinous neoplasm (IPMN of the pancreas is acceptable as a distinct disease entity, the concept of mucin-secreting biliary tumors has not been fully established. Case presentation We describe herein a case of mucin secreting biliary neoplasm. Imaging revealed a cystic lesion 2 cm in diameter at the left lateral segment of the liver. Duodenal endoscopy revealed mucin secretion through an enlarged papilla of Vater. On the cholangiogram, the cystic lesion communicated with bile duct, and large filling defects caused by mucin were observed in the dilated common bile duct. This lesion was diagnosed as a mucin-secreting bile duct tumor. Left and caudate lobectomy of the liver with extrahepatic bile duct resection and reconstruction was performed according to the possibility of the tumor's malignant behavior. Histological examination of the specimen revealed biliary cystic wall was covered by micropapillary neoplastic epithelium with mucin secretion lacking stromal invasion nor ovarian-like stroma. The patient has remained well with no evidence of recurrence for 38 months since her operation. Conclusion It is only recently that the term "intraductal papillary mucinous neoplasm (IPMN," which is accepted as a distinct disease entity of the pancreas, has begun to be used for mucin-secreting bile duct tumor. This case also seemed to be intraductal papillary neoplasm with prominent cystic dilatation of the bile duct.

  18. What does the Unexpected Detection of Water Vapor in Arcturus' Atmosphere Tell us?

    CERN Document Server

    Ryde, N; Richter, M J; Lacy, J H; Greathouse, T K; Ryde, Nils; Lambert, David L.; Richter, Matthew J.; Lacy, John H.; Greathouse, Thomas K.

    2002-01-01

    In this talk I presented and discussed our unexpected detection of water vapor in the disk-averaged spectrum of the K2IIIp red giant Arcturus [for details, see Ryde et al. (2002)]. Arcturus, or alpha Bootes is, with its effective temperature of 4300 K, the hottest star yet to show water vapor features. We argue that the water vapor is photospheric and that its detection provides us with new insights into the outer parts of the photosphere. We are not able to model the vater vapor with a standard, one-component, 1D, radiative-equilibrium, LTE model photosphere, which probably means we are lacking essential physics in such models. However, we are able to model several OH lines of different excitation and the water-vapor lines satisfactorily after lowering the temperature structure of the very outer parts of the photosphere at log tau_500=-3.8 and beyond compared to a flux-constant, hydrostatic, standard marcs model photosphere. Our new semi-empirical model is consistently calculated from the given temperature s...

  19. Die Erfindung des „traditionellen Vaters“ The Invention of the ‘Traditional Father’

    Directory of Open Access Journals (Sweden)

    Julia Nentwich

    2006-07-01

    Full Text Available In den meisten Diskussionen zum Thema ‚Vater‘ wird vom „traditionellen“ Vater gesprochen. Die Kritik, dass dabei nicht hinreichend geklärt wird, was damit jeweils gemeint ist und was sich hinter diesen Vorstellungen verbirgt, ist für Barbara Drinck Ausgangspunkt, verschiedene Vaterdiskurse zu analysieren. Sie untersucht in beeindruckender Detailgenauigkeit die wichtigsten Vatertheorien und Vaterbilder auf der Grundlage von pädagogischen, psychologischen und soziologischen Beiträgen der letzten 250 Jahre.In most discussions on the topic of the ‘father,’ the reference is made to the ‘traditional’ father. The inadequately explained criticism of this fact, what is meant by this criticism, and what hides behind these conceptions form Barbara Drinck’s point of departure for her analysis of various father discourses. She examines the important father theories and father images with impressive detail-specific precision on the basis of pedagogical, psychological, and sociological contributions from the last 250 years.

  20. Overlap of PIV syndrome, VACTERL and Pallister-Hall syndrome: clinical and molecular analysis.

    Science.gov (United States)

    Killoran, C E; Abbott, M; McKusick, V A; Biesecker, L G

    2000-07-01

    The polydactyly, imperforate anus, vertebral anomalies syndrome (PIV, OMIM 174100) was determined as a distinct syndrome by Say and Gerald in 1968 (Say B, Gerald PS. Lancet 1968: 2: 688). We noted that the features of PIV overlap with the VATER association and Pallister-Hall syndrome (PHS, OMIM 146510), which includes polydactyly, (central or postaxial), shortened fingers, hypoplastic nails, renal anomalies, imperforate anus, and hypothalamic hamartoma. Truncation mutations in GL13, a zinc finger transcription factor gene, have been shown to cause PHS. We performed a molecular evaluation on a patient diagnosed with PIV, whose mother, grandfather, and maternal aunt had similar malformations. We sequenced the GLI3 gene in the patient to determine if she had a mutation. The patient was found to have a deletion in nucleotides 2188-2207 causing a frameshift mutation that predicts a truncated protein product of the gene. Later clinical studies demonstrated that the patient also has a hypothalamic hamartoma, a finding in PHS. We concluded that this family had atypical PHS and not PIV. This result has prompted us to re-evaluate the PIV literature to see if PIV is a valid entity. Based on these data and our examination of the literature, we conclude that PIV is not a valid diagnostic entity. We conclude that patients diagnosed with PIV should be reclassified as having VACTERL, or PHS, or another syndrome with overlapping malformations.

  1. Electrical activity in the human oviduct during the menstrual cycle.

    Science.gov (United States)

    Talo, A; Pulkkinen, M O

    1982-01-15

    Electrical activity in 25 isolated human oviducts on different days of the menstrual cycle was recorded with six simultaneous suction electrodes in at least 18 locations. During the follicular phase, electrical activity consisted of a smooth, single slow spike that lasted 3 to 6 seconds, and on which was superimposed a fast spike(s) in the ampulla immediately after menstruation. The shape of this activity changed at midcycle, first in the ampulla and later in the isthmus, to a burst of potentials; in the ampulla it sometimes changed to a slow wave on which was superimposed a series of fast spikes. The pacemakers were stable and their number few. The electrical activity spread with a velocity of 1 to 3 mm/sec. The probability of spread toward the uterus varied with the location in the oviduct and with the day of the cycle. After menstruation, electrical activity spread in the uterine direction. On cycle day 12, activity spread toward the ampullary-isthmic junction (AIJ) from both ends of the oviduct. On days 14 and 15, it spread a short distance from the ampulla to the isthmus, through the AIJ. On cycle day 18, spread toward the uterus covered the uterine half of the ampulla. AIJ, and the isthmus. Two to 5 days later, no constant features could be detected in the spread. These findings suggest that the human oviduct functions like the oviducts of other mammalian species, with the spread of electrical activity and the transport of ova being related.

  2. Expression and immunolocalization of membrane progesterone receptors in the bovine oviduct.

    Science.gov (United States)

    Kowalik, M K; Martyniak, M; Rekawiecki, R; Kotwica, J

    2016-04-01

    The oviduct plays a crucial role in the transport and maturation of gametes and ensures suitable conditions for fertility and early embryo development. One regulator of oviduct function is progesterone (P4), which affects the cell by interacting with nuclear progesterone receptors (PGRs) and through nongenomic mechanisms, presumably involving membrane PGRs. The aim of this study was to evaluate the expression of messenger RNAS (mRNAs) and proteins for progesterone receptor membrane component (PGRMC) 1 and 2 and membrane progestin receptors (mPR) α, β, and γ and to use immunohistochemistry to demonstrate their cell-specific localization in the bovine oviduct. Oviducts ipsilateral and contralateral to the corpus luteum or to the dominant follicle were collected from cows on days 6 to 12 (midluteal stage) and 18 to 20 (follicular stage) of the estrous cycle and divided into 3 parts (infundibulum, ampulla, and isthmus). There were no differences (P > 0.05) in the PGRMC1, PGRMC2, mPRα, β, and γ mRNA expression between ipsi- and contralateral oviducts. However, the same parts of the oviduct collected during the different stages of the estrous cycle showed higher (P < 0.05) mRNA levels of PGRMC1, PGRMC2, and mPRα on days 18 to 20 than on days 6 to 12 of the estrous cycle. mPRα and mPRβ mRNA levels were higher (P < 0.05) in the infundibulum than in the isthmus, whereas PGRMC1 expression was higher (P < 0.05) in the infundibulum than in ampulla. Immunohistochemistry was used to detect PGRMC1, PGRMC2, PRα, β, and γ proteins in all parts of both oviducts from days 6 to 12 and 18 to 20 of the estrous cycle. There were no differences in the staining intensity and cellular localization of the studied proteins between the ipsi- and contralateral oviducts and between the studied stages of the estrous cycle. A strong positive reaction was observed in luminal cells, but this reaction was less evident in myocytes and stromal cells. All proteins were also localized to the

  3. Study of 50 cases of modern management of ectopic pregnancy

    Directory of Open Access Journals (Sweden)

    Rajita S. Jani

    2014-04-01

    Results: Lower abdominal pain was most common presenting symptom of ectopic pregnancy in 96% cases. The classical triad of symptoms (amenorrhea, abdominal pain and vaginal bleeding was present in only 28% cases. PID contributed 24% cases and previous abortion contributed 28% cases indicating these two as the common risk factors. Ampulla was the commonest site for ectopic pregnancy, in 52% cases. Salpingostomy performed mainly at this site. In 6% cases ectopic pregnancy in infundibulum were treated with fimbrial expression and fimbriectomy. 22% patients were managed medically (methotraxte. These were the cases having unruptured ectopic pregnancy and ectopic mass <4 cm. Laparoscopy was done in 34% cases, in 2 cases it was converted to laparotomy. While open laparotomy was done in 40% cases. Conclusions: Ectopic pregnancy is a treatable problem. Ultrasonography plays central role in the diagnosis and management. Mode of therapy is determined by a combination of clinical symptoms, sonography findings and serum b-HCG values. Surgical management is still a cornerstone of management of ectopic pregnancy. But now scope of medical and laparoscopic management is also there. In recent years laparotomy has been replaced by laparoscopic surgery which is more conservative, minimally invasive and less time consuming which leads to quick recovery. [Int J Reprod Contracept Obstet Gynecol 2014; 3(2.000: 374-379

  4. Mechanics of the cupula: effects of its thickness.

    Science.gov (United States)

    Njeugna, E; Eichhorn, J L; Kopp, C; Harlicot, P

    1992-01-01

    Mechanical aspects of the ampullar diaphragm, that is the crista ampullaris and the cupula, related to its thickness, are studied by a numerical method. Numerical methods are able to go beyond the limits of analytical approaches and are the only methods able to take into account this thickness. A finite elements method is applied to the median plane slice of the ampullar diaphragm. One assumes that the cupula sticks firmly without slipping, to the ampullar wall and to the crista ampullaris. The computation takes into account the pressures on the liquid interfaces and the deformations of the ampulla. So the volume swept over by the cupula during quasi-static deformations can be evaluated and the global elasticity coefficient of the human cupula can be calculated. The related value of the long time constant of the semicircular canal is close to the value obtained when measuring, in vivo, the activity on the vestibular nerve in animals. The thick cupula model clearly shows two different spatial distributions of strain on the hairs of the sensory cells, leading to a discrimination between the vestibular inflating pressure and the transcupular pressure difference. This result matches recent neurophysiological data and brings a new insight in the mechanics of the vestibular angular accelerometer and its regulation.

  5. Percutaneous transhepatic cholangiographic evaluation of obstructive jaundice

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hee Tae; Kim, Hong Soo; Kim, Jong Deok; Rhee, Hak Song [Presbyterian Medical Center, Jeonju (Korea, Republic of)

    1983-12-15

    PTC is the single most valuable diagnostic method available to evaluate the size, shape and site of the causes of obstructive jaundice among various radiological procedures. The authors reviewed and radiologically classified the PTC films of 203 cases of obstructive jaundice from July, 1977 to June, 1983 at Presbyterian Medical Center, Jeonju confirmed clinically, operatively and pathologically. The results are as follows; 1. The most common cause of obstructive jaundice was bile duct stone (64/203: 31.53%) and the other causes were bile duct cancer (43/203: 21.18%), pancreas cancer (41/203: 20.19%), biliary ascariasis and/or clonorchiasis (20/203: 9.8%), ampulla and duodenal cancer (7/203: 3.45%), fibrotic stenosis of sphincter of Oddi (6/203: 2.96%) etc. in the order. Of these primary involvement with cancer was more frequent (91/203: 44.33%) than stone. 3. The average maximal diameter of extrahepatic bile duct just proximal to the site of obstruction or stenosis by stones or by cancers was nearly equal (2.36 cm : 2.38 cm). 4. Cancers caused complete bile duct obstruction in about 75% (68/91) of cases and also were associated with intrahepatic duct dilatation about 92% (84/91) of cases. But in contrast biliary calculi showed good drainage of contrast medium in 75% (48/64) of cases and 92% (59/64) showed normal diameter.

  6. Effects of an electric field on white sharks: in situ testing of an electric deterrent.

    Directory of Open Access Journals (Sweden)

    Charlie Huveneers

    Full Text Available Elasmobranchs can detect minute electromagnetic fields, <1 nV cm(-1, using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1 the behaviour of 18 white sharks (Carcharodon carcharias near a static bait, and (2 the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks.

  7. Surgical Management of Ampullary Somatostatinoma

    Directory of Open Access Journals (Sweden)

    Nicholas Phillips

    2016-07-01

    Full Text Available Introduction Somatostatinomas of the ampulla are rare neuroendocrine tumours with limited studies in the literature. These are often associated with familial genetic predisposition e.g. NF 1 and Von Hippel-Lindau Syndrome. Histology commonly shows classical features such as Psammoma bodies. The classical presentation with inhibitory syndrome is rare, but ampullary mass effects can cause an earlier presentation with potentially better outcomes with earlier intervention and treatment. Case series We report three cases of ampullary somatostatisnomas: one sporadic and two familial, associated with neurofibromatosis type 1. The first patient presented with pruritus, the second with recurrent pancreatitis and the third, with elevated CA19-9 levels. Various preoperative localisation techniques were employed and one had an attempted endoscopic resection yielding involved margins. All patients underwent pancreaticoduodenectomy, of which one was laparoscopic assisted. The median size of the tumour was 10 mm and one patient had nodal involvement. All 3 patients have remained disease free at most recent follow up ranging from 1.5 to 11 years. Discussion Ampullary somatostatinomas can present early with mass related effects while inhibitory syndrome is rare. Early detection and intervention in ampullary somatostatinoma may contribute to better outcomes than pancreatic somatostatinomas. Long-term survival is achievable through pancreaticoduodenectomy for resectable ampullary somatostatinoma and laparoscopic approach is a feasible and viable option.

  8. Ultrastructural aspects of the oesophageal and reproductive systems of the equine parasite Strongylus vulgaris.

    Science.gov (United States)

    Mobarak, M S; Ryan, M F

    2002-06-01

    The ultrastructure of the dorsal oesophageal gland ampulla and its relationship with the oesophagus, oesophageal ultrastructure, and control mechanisms in oesophageal activity were studied. Terminal ducts of the sub-ventral glands open through the oesophageal crown at the base of the buccal cavity. The terminal duct of the dorsal oesophageal gland running through the dorsal gutter opens to the exterior at the rim 'groove' of the buccal capsule. The posterior oesophageal region is clavate and the cuticle of the lumen folds to form outlet valves, 'valvulae'. An inconspicuous oesophago-intestinal valve (three lobes) connects oesophagus and intestine and is visualized in the open and shut position. In the female reproductive tract, with the exception of the uterus, the cells lie on a thick, irregular (convoluted) basal lamina. The apical plasma membrane of the uterus, and seminal receptacle, extend into the lumen by microvilli-like projections with which spermatozoa make intimate contact. The lumen of the uterus is filled with oocytes, fertilized and unfertilized. Testicular cells have two parts linked by a rachis. Spermatocytes are elongated with a large nucleus, distinct nuclear membrane, and many granules. The apical membrane of the rachis forms long microvilli-like projections with balloon-like tips. The amoeboid spermatozoa contain membrane specializations, a nucleus devoid of a membrane, and are enclosed by a pseudopodial-like extension.

  9. A Rare Case of Intussusception Associated with Metastasize Small Cell Carcinoma of Lung

    Directory of Open Access Journals (Sweden)

    Razrim Rahim

    2012-11-01

    Full Text Available Intussusception is common cause of bowel obstruction in the paediatric age group compared to the elderly population. Many times, The diagnosis may be difficult because of asymptomatic nature of thisbowel disorder. We hereby describe the case of a 75-year-old male who presented with lethargy, weakness,loss of movement in the joints and was found to be anemic. The haemoglobin level was low so he wastransfused with packed cells. On gastrointestinal (GI endoscopy, upper GI bleed was observed. A mass was observed beyond ampulla at the 2nd and 3rd part of the duodenal junction. Computerized tomography (CTscan also showed a mass at the head of pancreas and the lesion at the left lung. In view of persistent bleed,‘Whipple’s procedure’ was performed. Histopathological examination showed small cell carcinoma of the lungs with metastasis to the pancreas and the jejunum. We here discuss the case of intussusception with intestinal metastasis which presented with gastrointestinal bleeding.

  10. Effects of delayed transfer and treatment with oestrogen on the transport of microspheres by the rat oviduct.

    Science.gov (United States)

    Moore, G D; Croxatto, H B

    1988-07-01

    Starch or dextran blue microspheres were transferred microsurgically to the infundibulum of the oviduct on Days 1, 2, or 3 of pregnancy of control and oestradiol-treated rats. The animals were killed a few hours to several days after transfer to assess the number and distribution of ova and microspheres in the tract. After transfer on Day 1 of pregnancy, microspheres and eggs crossed the ampullary-isthmic junction (AIJ) 18 h after ovulation. After transfer on Day 2 of pregnancy, more than 50% of microspheres were retained in the ampulla, indicating that the AIJ changes again 34 h after ovulation. Treatment with oestradiol did not advance the passage of eggs or microspheres across the AIJ but caused accelerated transport through the isthmus as soon as the eggs or microspheres reached this segment. Dextran blue microspheres were seen to move back and forth in the isthmus of control anaesthetized rats at a frequency of 5-6 times/min. Between 7 and 20 h after treatment with oestradiol the frequency of these movements was significantly augmented, indicating that increased frequency of contractions of the smooth muscle of the isthmus precedes and accompanies accelerated transport of ova through this segment.

  11. Gastrointestinal hormones and motility of the human sphincter of Oddi.

    Science.gov (United States)

    Ono, K; Suzuki, H; Hada, R; Sasaki, M; Endoh, M

    1985-07-01

    We investigated the mechanism of humoral control of bile discharge into the duodenum. The actions of the GB, SO and duodenum were monitered by cinecholecystocholangiogrphy combined with manometry of the SO area using a hydraulic-capillary infusion system or MIKRO-TIP, and these were correlated with the plasma concentrations of GI hormones. We concluded that one of the most significant roles of the sphincter of Oddi is to limit bile flow. This postulation was favored by the observation of so-called 'spasm' of the SO where 8 to 10 contractions per min., in contrast to 'normal' contraction of 2 to 4 per min., were seen. On this special occasion, no discharge of the contrast material into the duodenum was noticed. Exogenous or endogenous CCK causes a coordinated action of the GB contraction, the SO relaxation and relaxation of the adjacent segment of the duodenum, resulting in an effective discharge of bile into the duodenum. The effect of Pancreozymin on bile discharge revealed by endoscopic cinematography was that Pancreozymin first made the orifice of the papilla of Vater widely open with a profuse bile flow and following this, caused a repeated shuttering action of the orifice with minimal discharge of bile. This observation opposes the opinion that active SO contractile activity is necessary to bile flow into the duodenum. Caerulein or CCK-33 caused no 'post-inhibition' enhancement of the SO activity that was seen in case of Pancreozymin administration. Motilin, calcium or other substances contained in Pancreozymin (Boots) might be causative for this enhancement.

  12. Repair of postirradiation damage to colorectum: a progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bricker, E.M.; Johnston, W.D.; Patwardhan, R.V.

    1981-05-01

    The results of 21 operations for repair of rectovaginal fistula and/or stricture secondary to irradiation for pelvic cancer are presented. The operations rely on the use of proximal nonirradiated colon with normal blood supply for effecting the repair. In patients having had a previous colostomy, it is possible to use the proximal end of the bypassed colon for this purpose. There is minimal dissection of the rectal ampulla and the presacral space is never entered. Continuity is established by anastomosis to the anterior rectal wall via an abdominal approach alone, or by a combined abdominovaginal or abdominoperineal approach. It has been found that nonirradiated colon of normal vascularity can be expected to heal to irradiated colon or rectum, thus making the extensive resections associated with correction of these abnormalities unnecessary. The functional result in 18 of 19 patients who underwent this procedure was satisfactory to excellent. One patient had a poor result because of partial rectal incontinence. Two operations out of the 21 were total failures and one of these patients died of complications secondary to irradiation damage to the small intestine. One patient has not yet had final colostomy closure. The results are considered promising enough to warrant continued trial.

  13. Endoscopic ultrasound for the characterization and staging of rectal cancer. Current state of the method. Technological advances and perspectives.

    Science.gov (United States)

    Gersak, Mariana M; Badea, Radu; Graur, Florin; Hajja, Nadim Al; Furcea, Luminita; Dudea, Sorin M

    2015-06-01

    Endoscopic ultrasound is the most accurate type of examination for the assessment of rectal tumors. Over the years, the method has advanced from gray-scale examination to intravenous contrast media administration and to different types of elastography. The multimodal approach of tumors (transrectal, transvaginal) is adapted to each case. 3D ultrasound is useful for spatial representation and precise measurement of tumor formations, using CT/MR image reconstruction; color elastography is useful for tumor characterization and staging; endoscopic ultrasound using intravenous contrast agents can help study the amount of contrast agent targeted at the level of the tumor formations and contrast wash-in/wash-out time, based on the curves displayed on the device. The transvaginal approach often allows better visualization of the tumor than the transrectal approach. Performing the procedure with the rectal ampulla distended with contrast agent may be seen as an optimization of the examination methodology. All these aspects are additional methods for gray-scale endoscopic ultrasound, capable of increasing diagnostic accuracy. This paper aims at reviewing the progress of transrectal and transvaginal ultrasound, generically called endoscopic ultrasound, for rectal tumor diagnosis and staging, with emphasis on the current state of the method and its development trends.

  14. Simulation of cupulolithiasis and canalolithiasis by an animal model.

    Science.gov (United States)

    Valli, Paolo; Botta, Laura; Zucca, Gianpiero; Valli, Stefano; Buizza, Angelo

    2008-01-01

    The physical mechanisms responsible for cupulolithiasis and canalolithiasis have been investigated by two groups of experiments in isolated posterior semicircular canal (SCC) of frog (Rana esculenta L.). First, clouds of 10-30 isolated otoconia were let to fall (snowfall of otoconia) either through the ampulla onto the cupula, or inside the long arm of the canal, opposite to the cupula. Second, microspheres ranging 30 to 350 microm in diameter were gently moved to and fro inside the long arm of the canal by a micromanipulator. The effects were evaluated by recording the firing rate (Nfr) of the ampullary nerve. Snowfall of otoconia produced detectable changes of Nfr only when otoconia got in contact with the cupula, but not when falling through the endolymph. Movement of the microspheres in the canal long arm induced Nfr changes only if the microsphere diameter exceeded about 50 microm. Although the exact microsphere size needed for receptor stimulation may depend on the experimental conditions, these results strongly suggest that debris moving inside a SCC (canalolithiasis) can produce transcupular pressures able to stimulate ampullar receptors only if they have suitable size, whereas isolated otoconia cannot, except when lying on the cupula (cupulolithiasis).

  15. Cryptosporidium spp. infection in mares and foals of the northwest region of São Paulo State, Brazil.

    Science.gov (United States)

    Inácio, Sandra Valéria; de Brito, Roberta Lomonte Lemos; Zucatto, Anaiza Simão; Coelho, Willian Marinho Dourado; de Aquino, Monally Conceição Costa; Aguirre, André de Abreu Rangel; Perri, Silvia Helena Venturoli; Meireles, Marcelo Vasconcelos; Bresciani, Katia Denise Saraiva

    2012-01-01

    The present study aimed to analyze the occurrence of infection by Cryptosporidium spp. in mares and their respective foals. This study was carried out in 11 farms located in the municipalities of Araçatuba, Birigui, Guararapes and Santo Antônio do Aracangua, in the northwest region of the State of Sao Paulo, from November 2010 to March 2011. A total of 98 mares and 98 foals of several breeds were analyzed; among foals, 59 were males and 39 females, aged from three to 330 days. Feces were collected directly from the rectal ampulla, purified and processed according to modified Kinyoun stain. Occurrence of Cryptosporidium spp. was 21.4% (21/98) for foals and 18.4% (18/98) for mares. Occurrence of Cryptosporidium spp. had significant association with breeds and age of animals. Results obtained led to the conclusion that foals older than two months and Mangalarga animals are less susceptible to the occurrence of Cryptosporidium spp.

  16. Gross anatomy of the intestine and its mesentery in the nutria (Myocastor coypus).

    Science.gov (United States)

    Pérez, W; Lima, M; Bielli, A

    2008-11-01

    The intestines and mesentery of the nutria (Myocastor coypus) have not been fully described. In the present study 30 adult nutrias were studied using gross dissection. The small intestine was divided into the duodenum, jejunum and ileum as usual. The duodenum started at the pylorus with a cranial portion, which dilated forming a duodenal ampulla. The ileum was located within the concavity of the caecum and attached to the coiled caecum by means of the iliocaecal fold. The ascending colon had two ansae, one proximal and one distal. The proximal ansa was fixed to the caecum by the caecocolic fold. The base of the caecum and a short proximal part of the ascending colon belonging to the proximal ansa were attached to the mesoduodenum descendens. The distal ansa of the ascending colon had a proximal part which was sacculated and a distal part which was smooth. The two parts of the distal ansa of the ascending colon were parallel and joined by a flexure of variable localisation. The smooth part of the distal ansa of the ascending colon was attached to the initial portion of the descending colon by a peritoneal fold. The short transverse colon was directly attached to the mesoduodenum and greater omentum. In conclusion, we have described the anatomy of the intestines of the nutria and its mesentery in detail, and provided a nomenclature list adapted to the Nomina Anatomica Veterinaria.

  17. Immunolocalization of FGF8/10 in the Apical Epidermal Peg and Blastema of the regenerating tail in lizard marks this apical growing area.

    Science.gov (United States)

    Alibardi, Lorenzo

    2016-07-01

    Previous studies have shown that Fibroblast Growth Factors are present in the regenerating tail tissues of lizards where they may stimulate the process of regeneration. The present study is focused on the immunolocalization of FGF8 and FGF10 in the regenerating lizard tail, two signaling proteins of the apical epidermal cup/ridge and mesenchymal blastema sustaining tail and limb regeneration in amphibians and the development of the tail and limbs in vertebrate embryos. Main immunoreactive protein bands at 15-18kDa for FGF8/10 are detected in the regenerating epidermis and only a band at 30 or 35kDa in the underlying connective tissues. FGF8 appears particularly localized in cells and nuclei of the apical epidermal peg and of the ependymal ampulla present at the tip of the regenerating tail. FGF10 is also immuno-localized in the apical epidermis but is particularly intensely localized in the mesenchyme of the apical blastema. In accordance with previous studies, the present observations supports the hypothesis that the apical epidermal peg and the ependymal tube with the few regenerated neurons present within it, release FGF8/10 that may contribute to maintenance of cell proliferation in the apical front of the mesenchyme for the growth of the regenerating tail.

  18. Hydrodynamical properties of recombinant spider silk proteins: Effects of pH, salts and shear, and implications for the spinning process.

    Science.gov (United States)

    Leclerc, Jérémie; Lefèvre, Thierry; Gauthier, Martin; Gagné, Stéphane M; Auger, Michèle

    2013-09-01

    We have investigated the effect of pH, salts and shear on the hydrodynamical diameter of recombinant major ampullate (MA) rMaSpI silk proteins in solution as a function of time using (1) H solution NMR spectroscopy. The results indicate that the silk proteins in solution are composed of two diffusing populations, a high proportion of "native" solubilized proteins and a small amount of high molecular weight oligomers. Similar results are observed with the MA gland content. Salts help maintaining the proteins in a compact form in solution over time and inhibit aggregation, the absence of salts triggering protein assembly leading to a gel state. Moreover, the aggregation kinetics of rMaSpI at low salt concentration accelerates as the pH is close to the isoelectric point of the proteins, suggesting that the pH decrease tends to slow down aggregation. The data also support the strong impact of shear on the spinning process and suggest that the assembly is driven by a nucleation conformational conversion mechanism. Thus, the adjustment of the physicochemical conditions in the ampulla seems to promote a stable, long term storage. In addition, the optimization of protein conformation as well as their unfolding and aggregation propensity in the duct leads to a specifically organized structure.

  19. Reproductive Biology of Bothrops erythromelas from the Brazilian Caatinga

    Directory of Open Access Journals (Sweden)

    Verônica Alberto Barros

    2014-01-01

    Full Text Available The reproductive biology of Bothrops erythromelas, a small pit viper from the Caatinga, a semiarid biome in Brazil, is described based on analysis of individuals deposited in zoological collections. Males are smaller and also attain sexual maturity at a smaller size than females. Female reproductive cycle is seasonal with an extended period of secondary vitellogenesis and births occurring in a restricted period from late spring to early summer. Sperm storage in females may probably occur in infundibular tubular glands and uterine muscular twisting (UMT, which is a polymorphic condition within B. erythromelas. Seasonal spermatogenesis in males is variable with some intraspecific variation regarding the male reproductive stage per season. Most males are reproductively active during spring/summer and reproductively quiescent during autumn/winter, although some individuals vary (e.g., show testicular spermatogenesis and active sexual segment of the kidneys (SSK during winter. The SSK could be identified in every male. Most males showed highly hypertrophied SSK in spring/summer and moderately hypertrophied SSK in autumn/winter. The ampulla ductus deferentis was observed and histochemical reactions were conducted. We discuss the probable influence of the unique environmental conditions of the Caatinga region and phylogenetic inertia in the reproductive patterns of this snake species.

  20. Complementary role of helical CT cholangiography to MR cholangiography in the evaluation of biliary function and kinetics

    Energy Technology Data Exchange (ETDEWEB)

    Eracleous, Eleni; Genagritis, Marios; Kontou, Allayioti Maria [Diagnostic Center of Ayios Therissos, Department of Radiology, Nicosia (Cyprus); Papanikolaou, Nicos; Prassopoullos, P.; Chrysikopoulos, Haris; Gourtsoyiannis, Nicholas [University of Crete, Department of Radiology, Heraklion (Greece); Allan, Paul [Royal Infirmary of Edinburgh, Department of Radiology, Edinburgh (United Kingdom)

    2005-10-01

    To explore the potential role of computed tomographic cholangiography (CTC) in relation to magnetic resonance cholangiography (MRC) in cases in which knowledge of biliary kinetics and functional information are important for therapeutic decisions, 31 patients (14 men and 17 women) underwent MRC followed by CTC. We examined nine post-cholecystectomy cases with right upper quadrant abdominal pain, six cases with a previous biliary-enteric anastomosis and clinical evidence of cholangitis, eight biliary strictures with pain or symptoms of cholangitis, four cases with strong clinical evidence of sclerosing cholangitis, three cases with suspected post-laparoscopic cholecystectomy bile leakage, and one case with chronic pancreatitis and a common bile duct stent associated with cholangitis. In relation to MRC, CTC provided additional biliary functional information as follows: abnormal biliary drainage through the ampulla in 7/9 cholecystectomy cases, impaired drainage in 3/6 biliary-enteric anastomoses, and complete obstruction in 2/8 biliary strictures. CTC diagnosed early sclerosing cholangitis in 4/4 cases and confirmed suspected bile leakage in 1/3 post-laparoscopic cholecystectomy patients, and the patency of the biliary stent in the patient with chronic pancreatitis. Thus, CTC provides clinically important information about the function and kinetics of bile and complements findings obtained by MRC. (orig.)

  1. Cupula displacement, hair bundle deflection, and physiological responses in the transparent semicircular canal of young eel.

    Science.gov (United States)

    Rüsch, A; Thurm, U

    1989-03-01

    The transparent labyrinth of young eels (Anguilla anguilla L.) was used in toto for studying the configuration of cupula displacement, deflection of the hair bundle, and correlated changes in transepithelial voltage (delta TEV) and nerve activity (delta NA) in the semicircular canal. Microcapillaries were introduced into the canal through holes produced by a microthermocauter. Mechanical stimulation was applied either by injection of fluid into the ampulla or by electromagnetically displacing ferrofluid as a piston within the canal. Motion of individual kinocilia, stained cupulae or the ferrofluid piston was analysed by double-exposed microphotographs, photodiodes, or a video-system. The three-dimensional cupula displacement configuration was found to be piston- to diaphragm-like. Hair bundles at different sites on the crista exhibit differences in amplitude and time course of deflection. The transfer factor between shifts of the canal fluid and the tips of the kinocilia is 0.4-0.6. Displacements in opposite directions induce delta TEV and delta NA of opposite sign. Various tests confirmed delta TEV to reflect receptor potential responses. Nerve activity adapts to a tonic response with a time constant of 6.4 s. No similar adaptation occurred in delta TEV. Stimulus-response curves of TEV- and NA-responses are similar and sigmoid in shape with saturation at ciliary deflections of roughly +6 degrees and -3 degrees.

  2. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling.

    Science.gov (United States)

    Lin, Zhengshi; Cantos, Raquel; Patente, Maria; Wu, Doris K

    2005-05-01

    Gbx2 is a homeobox-containing transcription factor that is related to unplugged in Drosophila. In mice, Gbx2 and Otx2 negatively regulate each other to establish the mid-hindbrain boundary in the neural tube. Here, we show that Gbx2 is required for the development of the mouse inner ear. Absence of the endolymphatic duct and swelling of the membranous labyrinth are common features in Gbx2-/- inner ears. More severe mutant phenotypes include absence of the anterior and posterior semicircular canals, and a malformed saccule and cochlear duct. However, formation of the lateral semicircular canal and its ampulla is usually unaffected. These inner ear phenotypes are remarkably similar to those reported in kreisler mice, which have inner ear defects attributed to defects in the hindbrain. Based on gene expression analyses, we propose that activation of Gbx2 expression within the inner ear is an important pathway whereby signals from the hindbrain regulate inner ear development. In addition, our results suggest that Gbx2 normally promotes dorsal fates such as the endolymphatic duct and semicircular canals by positively regulating genes such as Wnt2b and Dlx5. However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression.

  3. Effect of tamoxifen on cytosolic estrogen receptor in the different parts of fallopian tube and uterus during ovum transport.

    Science.gov (United States)

    Gupta, J S; Roy, S K

    1987-12-01

    The effect of tamoxifen (ICI-46474) (alpha-[4-(beta-N-dimethylamino ethoxy)-phenyl]alpha'-ethyl trans stilbene on estrogen cytosolic receptor was observed in different parts of fallopian tube and uterus of rabbits during ovum transport. Tubal segments viz. ampulla (A), ampullary isthmic junction (AIJ), isthmus (I), uterine isthmic junction (UIJ) and uterus (U) were studied during the passage of ovum. Significant differences were observed in normal, drug treated and pregnant animals at 14, 24, 34, 48, 72, 144 and 168 h. In treated animals during 14 h post-coitum (p.c.) to 34 h p.c. the ampullary cytosol receptor concentration increased and suddenly decreased at 48 h p.c. whereas from 72 h p.c. to 144 h p.c. it increased gradually. Tamoxifen accelerated the rate of egg transport decreasing tubal cytosolic receptors at 48 h p.c. However, beyond 48 h p.c. receptors increased till 144 h p.c. Results suggest that tamoxifen modulated tubal cytosolic estrogen receptors during egg transport and prevents pregnancy.

  4. Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear.

    Science.gov (United States)

    Dernedde, Jens; Weise, Christoph; Müller, Eva-Christina; Hagiwara, Akira; Bachmann, Sebastian; Suzuki, Mamoru; Reutter, Werner; Tauber, Rudolf; Scherer, Hans

    2014-01-01

    The extracellular membranes of the inner ear are essential constituents to maintain sensory functions, the cupula for sensing torsional movements of the head, the otoconial membrane for sensing linear movements and accelerations like gravity, and the tectorial membrane in the cochlea for hearing. So far a number of structural proteins have been described, but for the gelatinous cupula precise data are missing. Here, we describe for the first time a major proteinogenic component of the cupula structure with an apparent molecular mass of 45 kDa from salmon. Analyses of respective peptides revealed highly conserved amino-acid sequences with identity to zona pellucida-like domain proteins. Immunohistochemistry studies localized the protein in the ampulla of the inner ear from salmon and according to its anatomical appearance we identified this glycoprotein as Cupulin. Future research on structure and function of zona pellucida-like domain proteins will enhance our knowledge of inner ear diseases, like sudden loss of vestibular function and other disturbances.

  5. Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear.

    Directory of Open Access Journals (Sweden)

    Jens Dernedde

    Full Text Available The extracellular membranes of the inner ear are essential constituents to maintain sensory functions, the cupula for sensing torsional movements of the head, the otoconial membrane for sensing linear movements and accelerations like gravity, and the tectorial membrane in the cochlea for hearing. So far a number of structural proteins have been described, but for the gelatinous cupula precise data are missing. Here, we describe for the first time a major proteinogenic component of the cupula structure with an apparent molecular mass of 45 kDa from salmon. Analyses of respective peptides revealed highly conserved amino-acid sequences with identity to zona pellucida-like domain proteins. Immunohistochemistry studies localized the protein in the ampulla of the inner ear from salmon and according to its anatomical appearance we identified this glycoprotein as Cupulin. Future research on structure and function of zona pellucida-like domain proteins will enhance our knowledge of inner ear diseases, like sudden loss of vestibular function and other disturbances.

  6. Clincial analysis of the relative onset factors of 120 cases of ectopic pregnancy%120例异位妊娠发病相关因素的临床分析

    Institute of Scientific and Technical Information of China (English)

    任英俊

    2011-01-01

    目的 探讨异位妊娠的发病相关因素及治疗方法,为生育健康和保健工作提供科学依据.方法 回顾性分析2006年7月至2010年5月本院收治的120例异位妊娠患者的临床资料.结果 壶腹部妊娠较其他部位输卵管妊娠比例明显增高(P0.05).结论 异位妊娠的致病因素复杂,盆腔炎性病变、流产史、宫内节育器史、异位妊娠史是异位妊娠发生的危险因素.%Objective To investigate the incidence of ectopic pregnancy-related factors and treatment,and provide scientific basis for reproductive health and health care. Methods Retrospective analysis from July 2006 to May 2010,120 cases of ectopic pregnancy treated patients with clinical information.Results The rate of ectopic pregnancy in the ampullae of oviduct was markedly higher than that in other part of oviduct(P0.05).Conclusions The ectopic pregnancy risk factors is complex,including pelvic inflammatory disease, abortion, IUD and ectopic pregnancy history.

  7. The structure of the cushions in the feet of African elephants (Loxodonta africana).

    Science.gov (United States)

    Weissengruber, G E; Egger, G F; Hutchinson, J R; Groenewald, H B; Elsässer, L; Famini, D; Forstenpointner, G

    2006-12-01

    The uniquely designed limbs of the African elephant, Loxodonta africana, support the weight of the largest terrestrial animal. Besides other morphological peculiarities, the feet are equipped with large subcutaneous cushions which play an important role in distributing forces during weight bearing and in storing or absorbing mechanical forces. Although the cushions have been discussed in the literature and captive elephants, in particular, are frequently affected by foot disorders, precise morphological data are sparse. The cushions in the feet of African elephants were examined by means of standard anatomical and histological techniques, computed tomography (CT) and magnetic resonance imaging (MRI). In both the forelimb and the hindlimb a 6th ray, the prepollex or prehallux, is present. These cartilaginous rods support the metacarpal or metatarsal compartment of the cushions. None of the rays touches the ground directly. The cushions consist of sheets or strands of fibrous connective tissue forming larger metacarpal/metatarsal and digital compartments and smaller chambers which were filled with adipose tissue. The compartments are situated between tarsal, metatarsal, metacarpal bones, proximal phalanges or other structures of the locomotor apparatus covering the bones palmarly/plantarly and the thick sole skin. Within the cushions, collagen, reticulin and elastic fibres are found. In the main parts, vascular supply is good and numerous nerves course within the entire cushion. Vater-Pacinian corpuscles are embedded within the collagenous tissue of the cushions and within the dermis. Meissner corpuscles are found in the dermal papillae of the foot skin. The micromorphology of elephant feet cushions resembles that of digital cushions in cattle or of the foot pads in humans but not that of digital cushions in horses. Besides their important mechanical properties, foot cushions in elephants seem to be very sensitive structures.

  8. Broken heart as work-related accident: Occupational stress as a cause of takotsubo cardiomyopathy in 55-year-old female teacher – Role of automated function imaging in diagnostic workflow

    Directory of Open Access Journals (Sweden)

    Agnieszka Mielczarek

    2015-12-01

    Full Text Available Takotsubo cardiomiopathy (TTC (known also as “ampulla cardiomyopathy,” “apical ballooning” or “broken heart syndrome” is connected with a temporary systolic left ventricular dysfunction without the culprit coronary lesion. Takotsubo cardiomyopathy was first described in 1990 in Japan after octopus trapping pot with a round bottom and narrow neck similar in shape to left ventriculogram in TTC patients. The occurrence of TTC is usually precipitated by a stressful event with a clinical presentation mimicking myocardial infarction: chest pain, ST-T segment elevation or T-wave inversion, a rise in cardiac troponin, and contractility abnormalities in echocardiography. A left ventricular dysfunction is transient and improves within a few weeks. Takotsubo cardiomyopathy typically occurs in postmenopausal women and the postulated mechanism is catecholamine overstimulation. Moreover, the distribution of contractility impairments usually does not correspond with typical region supplied by a single coronary artery. Therefore, the assessment of regional pattern of systolic dysfunction with speckle-tracking echocardiography and automated function imaging (AFI technique may be important in diagnosis of TTC and may improve our insight into its patophysiology. We described a 55-year-old female teacher with TTC diagnosed after acute psychological stress in workplace. The provoking factor related with occupational stress and pattern of contraction abnormalities documented with AFI technique including basal segments of left ventricle make this case atypical.

  9. Percutaneous Transhepatic Removal of Bile Duct Stones: Results of 261 Patients

    Energy Technology Data Exchange (ETDEWEB)

    Ozcan, Nevzat, E-mail: nevzatcan@yahoo.com; Kahriman, Guven, E-mail: guvenkahriman@hotmail.com; Mavili, Ertugrul, E-mail: ertmavili@yahoo.com [Erciyes University, Department of Radiology, Medical Faculty (Turkey)

    2012-08-15

    Purpose: To determine the effectiveness of percutaneous transhepatic removal of bile duct stones when the procedure of endoscopic therapy fails for reasons of anatomical anomalies or is rejected by the patient. Methods: Between April 2001 and May 2010, 261 patients (138 male patients and 123 female patients; age range, 14-92 years; mean age, 64.6 years) with bile duct stones (common bile duct [CBD] stones = 248 patients and hepatolithiasis = 13 patients) were included in the study. Percutaneous transhepatic cholangiography was performed, and stones were identified. Percutaneous transhepatic balloon dilation of the papilla of Vater was performed. Then stones were pushed out into the duodenum with a Fogarty balloon catheter. If the stone diameter was larger than 15 mm, then basket lithotripsy was performed before balloon dilation. Results: Overall success rate was 95.7%. The procedure was successful in 97.5% of patients with CBD stones and in 61.5% of patients with hepatolithiasis. A total of 18 major complications (6.8%), including cholangitis (n = 7), subcapsular biloma (n = 4), subcapsular hematoma (n = 1), subcapsular abscess (n = 1), bile peritonitis (n = 1), duodenal perforation (n = 1), CBD perforation (n = 1), gastroduodenal artery pseudoaneurysm (n = 1), and right hepatic artery transection (n = 1), were observed after the procedure. There was no mortality. Conclusion: Our experience suggests that percutaneous transhepatic stone expulsion into the duodenum through the papilla is an effective and safe approach in the nonoperative management of the bile duct stones. It is a feasible alternative to surgery when endoscopic extraction fails or is rejected by the patient.

  10. Ascaris lumbricoides and its invasion of the accessory cystic duct: an unusual presentation.

    Science.gov (United States)

    Majid, Zain; Masood, Irfan; Pirzada, Muhammad Taqi

    2015-04-01

    Around the world, Ascaris lumbricoides is the most common helminthic infection. We describe the case of a 25-year-old woman, known to have had Ascaris infestation, presenting with abdominal pain, constipation and jaundice together with fever and tachycardia. There was tenderness in the right hypochondrium and liver function tests confirmed cholestatic jaundice. An abdominal ultrasound showed multiple linear echogenic foci in the distal small intestine along with cholelithiasis and a thick-walled gall bladder with a single stone compressing the common bile duct (Mirizzi syndrome). The patient underwent exploratory laparotomy; more than 100 worms were found inside the small intestine and they were removed by enterotomy and manual decompression. No worm could be palpated within the common bile duct (CBD). Cholecystectomy was performed, during which an accessory cystic duct was noted opening into the common bile duct superiorly to the main cystic duct. A 10 cm live worm was found coming out of it and was removed via forceps. Later on an endoscopic retrograde cholangio-pancreatogram (ERCP) showed a widened ampulla, a mildly dilated common bile duct, but without any filling defects. The patient made an uneventful postoperative recovery being discharged on the ninth day. Worms in an accessory cystic duct have not been report in the medical literature so far.

  11. Male and female reproductive systems of Stolas conspersa (Germar (Coleoptera, Chrysomelidae, Cassidinae

    Directory of Open Access Journals (Sweden)

    Marianna V. P. Simões

    2012-03-01

    Full Text Available Male and female reproductive systems of Stolas conspersa (Germar (Coleoptera, Chrysomelidae, Cassidinae. The male and female reproductive systems of Stolas conspersa (Germar, 1824 are described and illustrated for the first time. The male reproductive system shows no difference from the subfamily pattern, which is a tubular well-developed median lobe; "Y", "V" or T-shaped tegmen; reduced pygidium; internal sac membranous and tubular; flagellum generally well developed needle-like structured and gastral spiculum absent. However, the female differs from the pattern proposed for Stolas in two aspects: ovary with 28 ovarioles and a reduced ampulla with indistinct velum.Sistema reprodutivo masculino e feminino de Stolas conspersa (Germar (Coleoptera, Chrysomelidae, Cassidinae. O sistema reprodutivo do macho e fêmea de Stolas conspersa (Germar, 1824 são descritos pela primeira vez. Neste estudo, foi observado que o macho não diverge do padrão proposto para a subfamília, que é edeago tubular e bem desenvolvido; tégmen em forma de "Y", "V" ou "T"; pigídio reduzido; saco interno membranoso e tubular; flagellum geralmente bem desenvolvido, em forma de agulha e espículo gastral ausente. Por outro lado, o sistema reprodutor feminino diverge do padrão usual proposto para o gênero Stolas em dois aspectos: ovário com 28 ovaríolos e ampola reduzida com velum não distinto.

  12. Cardiac surgery of premature and low birthweight newborns: is a change of fate possible?

    Science.gov (United States)

    Alkan-Bozkaya, Tijen; Türkoğlu, Halil; Akçevin, Atif; Paker, Tufan; Ozkan-Çerçi, Hilda; Dindar, Aygün; Ersoy, Cihangir; Bayer, Vedat; Aşkin, Demet; Undar, Akif

    2010-11-01

    Low birthweight (LBW) continues to be a high-risk factor in surgery for congenital heart disease. This risk is particularly very high in very low birthweight infants under 1500g and extremely LBW infants under 1000g. From January 2005 to December 2008, 33 consecutive LBW neonates underwent cardiac surgery in our clinic in keeping with the criteria for choice of surgery. Their weight range was between 800 and 1900g. Nine of them were under 1000g. Cardiopulmonary bypass (CPB) was used in 17 patients (39.5%) and pulsatile perfusion mode was applied to patients in the CPB group. The same surgical team operated to achieve palliation (8 patients, 24.2%) or full repair (25 patients, 75.8%). Median gestational age was 36 weeks with 12 (36.4%) premature babies (≤37 weeks). Median age at operation was 5 days. Pathologies were single ventricle (n=3), pulmonary atresia-ventricular septal defect (n=3), aortic coarctation (n=10), aorticopulmonary window and interrupted aortic arch combination (n=6), patent arterial duct (n=11), critical aortic stenosis (n=8), and tetralogy of Fallot with pulmonary atresia (n=2). One infant had VATER syndrome. Selective cerebral perfusion technique was used in complex arch pathologies for cerebral protection. Median follow-up was 14 months. There were four early postoperative deaths. None of the cases showed a need for early reoperation. The acceptable early- and midterm mortality rates in this group suggest that these operations can be successfully performed. There is a need for further multicenter studies to evaluate these high-risk groups.

  13. 超声诊断胆总管扩张128例分析%Ultrasonic Diagnosis of Common Bile Duct Expansion in 128 Cases Analysis

    Institute of Scientific and Technical Information of China (English)

    朱渊

    2015-01-01

    Objective To discuss the common diseases and the cor esponding ultrasonic diagnosis of common bile duct dilatation.Methods The clinical data of 128 patients with common bile duct dilatation were retrospectively analyzed from 2013 to 2005.Methods:From 2005 to 2013 were retrospectively studied 128 cases of ultrasound diagnosis of common bile duct expansion in patients with clinical data.Results 128 cases of common bile duct stones were in 68 cases,26 cases of common bile duct ascariasis,12 cases of carcinoma of head of pancreas,5 cases of choledochal cyst,4 cases of carcinoma of ampul a of Vater,other diseases (including pancreatitis,cholangitis,the gal bladder and biliary surgery after disease)in 9 cases,unexplained cases in 3 cases.Conclusion The ultrasound examination has important value in the diagnosis and treatment of common bile duct disease.%目的探讨引起胆总管扩张的常见疾病及相应超声诊断分析。方法回顾性分析2005~2013年收治的128例超声诊断为胆总管扩张患者临床资料。结果128例中胆总管结石68例,胆总管蛔虫症26例,胰头癌12例,胆总管囊肿5例,壶腹癌4例,其它疾病(包括胰腺炎,胆管炎,胆囊胆道术后等疾病)9例,不明原因病例3例。结论超声检查对胆总管疾病的诊断及治疗有重要价值。

  14. The Return of Superman – Die Vermittlung eines neuen südkoreanischen Vaterideals durch eine doppelte Narrationsstruktur

    Directory of Open Access Journals (Sweden)

    Christian Toth

    2016-08-01

    Full Text Available In der südkoreanischen Reality-TV-Serie The Return of Superman kümmern sich prominente Väter 48 Stunden lang alleine um ihre Kinder, während die Mütter entweder arbeiten oder einen Kurzurlaub machen. Die südkoreanische Kultur ist stark konfuzianisch geprägt und damit traditionell paternalistisch, sodass Väter primär Versorger und nur sekundär Vater sind und dadurch quantitativ und qualitativ wenig Zeit in der Familie und mit ihren Kindern verbringen. Die Väter in der Serie entgegnen dieser traditionellen Vaterrolle eine neue, moderne Rolle. Sie verbringen viel Zeit mit ihren Kindern, sind ihnen physisch und emotional sehr nahe und vermitteln über die Sendung ihren Erfahrungszuwachs, ihre Freude und Erziehungsratschläge. Diese widersprüchlichen Vaterrollen werden aus einer kulturtheoretischen Perspektive diskutiert und anhand ausgewählter Szenen der Serie kontrastiert, um die Generierung serieller Narrationsstrukturen auf ihre Serialisierungslogik zu prüfen. Dabei wird deutlich, dass sich die Lebenswelt ‹normaler› südkoreanischen Familien stark von der vorgelebten Lebenswelt der ‹Supermänner› unterscheidet und sie damit die Ausnahme von der Regel sind, wenngleich sie als Vorreiter für einen möglichen Wertewandel in der südkoreanischen Gesellschaft angesehen werden können. Für die Serienforschung werden kulturspezifische Analysestrukturen und innovative Elemente serieller Darstellungen benannt, sowie das Spezifikum dieses Serienformats in der doppelten Narrationsstruktur einer Unterhaltungs- und Dokumentationsnarration aufgezeigt.

  15. Reversible transient apical ballooning syndrome with coronary lesions

    Institute of Scientific and Technical Information of China (English)

    Yunshan Cao; Min Zhang; Xiang Li; Ping Xie; Lynn Cronin

    2009-01-01

    Transient apical ballooning syndrome(Tako-Tsubo syndrome or ampulla cardiomyopathy) occurs predominantly in women over 60 years of age with a history of recent physical or psychological stress. We present a case of a male patient with reversible transient apical ballooning syndrome with significant coronary lesions and other ECG changes that did not explain the clinical symptoms.

  16. Tratamiento paliativo de la obstrucción tumoral del vaciamiento gástrico con prótesis metálicas autoexpandibles insertadas endoscópicamente Palliative management of malignant gastric outlet obstruction with endoscopically inserted self-expanding metal stents

    Directory of Open Access Journals (Sweden)

    J. García-Cano

    2008-06-01

    Full Text Available Antecedentes y objetivo: la inserción de prótesis metálicas autoexpandibles para paliar la obstrucción tumoral del vaciamiento gástrico es un procedimiento mínimamente invasivo, que cada vez se utiliza con más frecuencia. Presentamos la experiencia de esta técnica en un hospital de nivel II del Sistema Nacional de Salud. Pacientes y métodos: estudio retrospectivo de un periodo de cinco años (2003-2007, en los que se trató de resolver la obstrucción tumoral del vaciamiento gástrico en 27 ocasiones a 23 pacientes (media de 0,45 procedimientos por mes, mediante la inserción endoscópica de prótesis no recubiertas (Wallstent® y Wallflex®. Resultados: la inserción fue técnicamente posible en el 100% de los 27 intentos. Se obtuvo un buen resultado clínico en 25 ocasiones (92,5%. Se utilizó sólo endoscopia 10 (37% veces y en las otras 17 (63% también fluoroscopia. Tras la inserción de la prótesis se intervino a un paciente con intención curativa y a otro, en el que la prótesis no funcionó, para realizar una derivación paliativa. Cuatro prótesis se obstruyeron por crecimiento tumoral, recanalizándose mediante la inserción de nuevas prótesis. En tres ocasiones se produjo ictericia obstructiva en prótesis que cubrían la papila de Vater. No hubo otras complicaciones. Tampoco mortalidad derivada del procedimiento. La media de supervivencia fue de 104 días (rango 28-400, DE ± 94. Conclusiones: en nuestra experiencia, la inserción endoscópica de prótesis metálicas autoexpandibles parece un método seguro y eficaz en el tratamiento paliativo de la obstrucción tumoral del vaciamiento gástrico y puede llevarse a cabo con éxito en un centro de nuestras características.Aim and background: the insertion of self-expanding metal stents to palliate malignant gastric outlet obstruction is a minimally invasive procedure that is being increasingly used. We discuss experience with this technique in a level-II hospital in the

  17. Distichopora vervoorti, a new shallow-water stylasterid coral (Cnidaria: Hydrozoa: Stylasteridae) from Bali, Indonesia

    NARCIS (Netherlands)

    Cairns, S.D.; Hoeksema, B.W.

    1998-01-01

    A new species of stylasterid coral, Distichopora vervoorti, is described from shallow water off Bali, Indonesia. Although similar to D. irregularis in having meandering pore rows, it differs from that species in colony and branch shape, coenosteal colour, and expression of the ampullae.

  18. Biliær papillomatose er en sjælden årsag til intermitterende obstruktiv ikterus

    DEFF Research Database (Denmark)

    Veedfald, Simon; Vainer, Ben; Wettergren, André

    2011-01-01

    Over a five-year period a 67 year-old male had been experiencing recurring bouts of biliary obstruction with occasional superimposed cholangitis. Renewed endoscopic retrograde cholangiopancreatography revealed amorphous filling defects and excessive mucinous discharge from the papilla of Vater....... Subsequent choledochoscopy demonstrated exophytic papillomatous lesions in the common and left hepatic bile duct. An extended left hemihepatectomy and resection of the common hepatic bile duct was performed. Histological examination revealed biliary papillomatosis - a rare lesion believed to be premalignant....

  19. INDUCTION OF GONADAL MATURATION OF POND CULTURED MALE TIGER SHRIMP, Penaeus monodon WITH DIFFERENT DOSAGES OF GONADOTROPIN RELEASING HORMONE ANALOGUE AGAINST EYE STALK ABLATION

    Directory of Open Access Journals (Sweden)

    Asda Laining

    2016-12-01

    Full Text Available Very low naturally mating rate of pond-reared tiger shrimp broodstock is probably due to the slow maturation of the male stock. The aim of this study was to evaluate the salmon gonadotrophin releasing hormone analoque (sGnRHa in stimulating the gonadal maturation of male stock of pond-reared tiger shrimp. The treatments were three dosages of sGnRHa at 0.1 (OV-1, 0.2 (OV-2, and 0.3 (OV-3 mL/kg of shrimp weight and control was eye stalk ablation (AB. The sGnRHa was administered via injection three times with one week interval. Male stocks with average initial body weight of 82.1 g were randomly distributed into four of 10 m3 concrete tanks, 26 males for each tank. Variables observed were performances of spermatophores and profiles of amino acid and fatty acid of muscle of the male stocks. After induction, number of male maturing indicated by spermatophores releasing from terminal ampullas was higher in shrimp induced with OV-1 (80.8% compared to control which was only 46.1%. Furthermore, shrimp treated OV-2 had the highest spermatophore weight of 0.16 g compared to control (0.11 g and other two groups. Amino acid profiles improved as the dose of sGnRHa increased up to 0.2 mL/kg from 61.23% for ablated male becoming 71.27% for OV-2. Total fatty acid also tended to improve by increasing the dose of hormone injection, however, the ablated male had higher total fatty acid content than that of OV-1. The present finding demonstrated that the dose of sGnRHa to stimulate the gonadal maturation of pond-reared male tiger shrimp could be applied at range between 0.1-0.2 mL/kg of shrimp weight.

  20. A comparison of the electrosensory morphology of a euryhaline and a marine stingray.

    Science.gov (United States)

    Camilieri-Asch, Victoria; Kempster, Ryan M; Collin, Shaun P; Johnstone, Ron W; Theiss, Susan M

    2013-10-01

    The electrosensory system is found in all chondrichthyan fishes and is used for several biological functions, most notably prey detection. Variation in the physical parameters of a habitat type, i.e. water conductivity, may influence the morphology of the electrosensory system. Thus, the electrosensory systems of freshwater rays are considerably different from those of fully marine species; however, little research has so far examined the morphology and distribution of these systems in euryhaline elasmobranchs. The present study investigates and compares the morphology and distribution of electrosensory organs in two sympatric stingray species: the (euryhaline) estuary stingray, Dasyatis fluviorum, and the (marine) blue-spotted maskray, Neotrygon kuhlii. Both species possess a significantly higher number of ventral electrosensory pores than previously assessed elasmobranchs. This correlates with a diet consisting of benthic infaunal and epifaunal prey, where the electrosensory pore distribution patterns are likely to be a function of both ecology and phylogeny. The gross morphology of the electrosensory system in D. fluviorum is more similar to that of other marine elasmobranch species, rather than that of freshwater species. Both D. fluviorum and N. kuhlii possess 'macro-ampullae' with branching canals leading to several alveoli. The size of the pores and the length of the canals in D. fluviorum are smaller than in N. kuhlii, which is likely to be an adaptation to habitats with lower conductivity. This study indicates that the morphology of the electrosensory system in a euryhaline elasmobranch species seems very similar to that of their fully marine counterparts. However, some morphological differences are present between these two sympatric species, which are thought to be linked to their habitat type.

  1. Effect of clomiphene on nuclear estrogen receptor of the fallopian tube during ovum transport in rabbits.

    Science.gov (United States)

    Gupta, J S; Roy, S K

    1989-01-01

    The effect of clomiphene on nuclear estrogen receptors of the Fallopian tube during ovum transport in the rabbit has been studied. Nuclear binding capacity was observed in ampulla (A), ampullary-isthmic junction (AIJ), isthmus (I), uterine-isthmic junction (UIJ) and uterus (U). Receptor concentration decreased in all segments of the tube after administration of clomiphene in mated animals. The bindings are of high affinity and low capacity. Important alterations were observed during transport when compared to that of 14, 24, 34, 48, 72, 144 and 168 hr post-coitum (p.c). At 24 hr p.c binding increased only in I and decreased in A and AIJ. Retention of eggs at I at 24 hr p.c showed as increase in binding at I. Egg transport was accelerated and eggs reached prematurely in the uterus due to the influence of clomiphene. Binding in I remained constant from 48 hr p.c to 144 hr p.c but concurrently the binding level increased in U from 34 hr p.c. The elevation of nuclear estrogen receptor level was maximum at 24 hr p.c which coincided with increased plasma estrogen level. The result of such study showed that clomiphene depleted nuclear estrogen receptor complex in the fallopian tube before transfer to the uterus. Further, observation indicated that clomiphene acted directly on the rate of egg transport because of the variations in estrogen receptors during different time periods. Thus, clomiphene reduced the quantity of estrogen receptor i.e., insensitiveness to estrogen. The variations in estrogen binding to its receptor and plasma level at different post-coital periods are modulated by clomiphene resulting in the acceleration of egg transport and prevention of pregnancy.

  2. Morphology and functions of the human seminal vesicle.

    Science.gov (United States)

    Aumüller, G; Riva, A

    1992-01-01

    The seminal vesicles originate in embryos of about 58 mm crown-rump-length from the Wolffian duct under the influence of testosterone. Along with the ampulla of the vas deferens and the ejaculatory duct, they form a functional unit that develops slowly until the onset of puberty. Developmental malformations occur as uni- or bilateral agenesis, aplasia, cysts, or ureterovesicular fistules. After puberty, the glands form sac-like structures which have a capacity of about 3.4-4.5 ccm and contribute about 70% of the seminal fluid. In addition to secretion, they are capable of reabsorption of fluids or dissolved substances, and of spermatophagy (ingestion and degradation of damaged spermatozoa by epithelial cells). Secretory activity of the glands is a measure of testosterone supplementation to the epithelium. Nervous regulation of secretion is realized by cholinergic post-ganglionic, sympathetic (and perhaps parasympathetic) fibres, derived from pelvic plexus. Contraction of the muscular wall occurs under the influence of excitatory adrenergic and modulatory NPY-encephalin-peptidergic nerve fibres. The secretory products of the seminal vesicles encompass (1) ions (K+: 1.1 mM ml-1) (2) low molecular weight substances (fructose: above 1.2 mg ml-1; prostaglandins above 250 microliters ml-1, (3) peptides (endorphin: 330 pg ml-1), and (4) proteins. In addition to plasma protein related forms such as transferrin, lactoferrin, and fibronectin, specific proteins such as semenogelin (52 kDa) are synthesized, the scaffold protein of semen coagulate forming the substrate for PSA (prostate specific antigen), sperm motility inhibitor (ca. 18 kDa), and others (placental protein 5, protein kinase inhibitor, carboanhydrase, 5'-nucleotidase), some of which are immunosuppressive. Therefore, functions of the seminal vesicles concern (a) formation of seminal coagulum, (b) modification of sperm functions (motility, capacitation), and (c) immunosuppression. Additional functions within the

  3. Investigation of the potential of optical coherence tomography (OCT) as a non-invasive diagnostic tool in reproductive medicine

    Science.gov (United States)

    Trottmann, Matthias; Homann, Christian; Leeb, R.; Doering, D.; Kuznetsova, J.; Reese, S.; Stief, C. G.; Koelle, S.; Sroka, R.

    2015-02-01

    Introduction and objective: In Europe, nearly every sixth couple in the reproductive age is involuntarily childless. In about 30%, both male and female reveal fertility problems. In about 10% of infertile men, azoospermia is the underlying cause. As conventional therapeutic options are limited, surgical testicular sperm extraction (TESE) is necessary to obtain sperms for assisted reproductive techniques. Regarding the females, up to 30% of all idiopathic infertilities are due to alterations of the uterine tube So far, no imaging technique, which does not require any labelling, is available to evaluate the male and female genital tract at a microscopic level under in vivo conditions. Thus, the aim of this study was to investigate the potential of optical coherence tomography (OCT) as a non-invasive diagnostic tool in gynaecology and andrology. Material and Methods: Tissues samples from the bovine testis, epididymis, vas deferens, ovary, oviduct (ampulla and isthmus) and uterus were obtained immediately after slaughter (14 cows aged 3 to 8 years and 14 bulls aged 3 to 6 years; breeds: Holstein- Friesian, and Deutsches Fleckvieh). Imaging was done by using the US Food and Drug Administration (FDA) approved probe-based Niris Imaging System (Imalux, Cleveland, Ohio, USA) and the Telesto 1325 nm OCT System and Ganymede 930 nm OCT System (Thorlabs Inc., Dachau, Germany). All images obtained were compared to histological images after paraffin embedding and HE staining. Results: OCT imaging visualized the microarchitecture of the testis, epididymis, spermatic duct and the ovary, oviduct and uterus. Using the Thorlabs systems a axial resolution of approx. 5μm and lateral resolution of 8- 15μm could be achieved. Different optical tissue volumes could be visualized, which depends on the optical penetration depth of the wavelength of the system used. While the tissue volume observed by probe based Imalux-OCT is similar to the used Thorlabs systems, the optical resolution is

  4. Examination of the cupula and stereocilia of the horizontal semicircular canal in the toadfish Opsanus tau.

    Science.gov (United States)

    Silver, R B; Reeves, A P; Steinacker, A; Highstein, S M

    1998-12-01

    We imaged the horizontal semicircular canal (HSCC) crista and cupula of toadfish, Opsanus tau, by using a) confocal light microscopy of isolated vital HSCC; b) serial sections of fixed, trichrome-stained HSCC; and c) scanning electron microscopy of fixed HSCCs. HSCC were dissections which included an ampulla and an attached canal tube (long and slender canal portion), and, in some cases, a small portion of the utricular wall. Cupulae were seen as multipartite mucus connective tissue shells rising from the crista and extending toward the ampullary roof. They were composed of several refractile bands traversing the cupulae perpendicular to longitudinal fibers extending from the cupular base to its apex. Alcian green-stained cupulae showed an asymmetric alcianphilic, dark, X-shaped structure, indicating that the pillar is rich in mucin and carbohydrate, an interpretation supported by images of trichrome-stained sections. The cupular antrum is devoid of prominent refractile fibers. No tubes or channels were observed in the cupula or antrum of vital preparations. Cupular shell fibers cover the surface of the crista, are roughly parallel, and are associated with a translucent material having a refractive index greater than the surrounding endolymph. Stereocilia were thin, 100-microm-long structures, with little longitudinal curvature, which end with no end bulb. No strands extend from stereocilia to the roof or other portions of the cupular antrum. Gross movements of stereocilia were not seen in mechanically quiescent preparations. Within the cupular antrum, stereocilia were parallel to connective tissue fibers, all embedded in an isotropic gel. This fiber-reinforced gel and cupular matrix are sensitive to N-acetlyneuraminidase and beta-N-acetyl glucosaminidase, and minimally sensitive to beta-N-acetyl hexosaminidase. Connective tissue fibers may serve to stiffen the gel, whose matrix would restrict lateral motion of embedded fibers and stereocilia thereby providing

  5. Morphology and Aquaporin Immunohistochemistry of the Uterine Tube of Saanen Goats (Capra hircus): Comparison Throughout the Reproductive Cycle.

    Science.gov (United States)

    Arrighi, S; Bosi, G; Frattini, S; Coizet, B; Groppetti, D; Pecile, A

    2016-06-01

    The expression of six different aquaporins (AQP1, 2, 3, 4, 5 and 9), integral membrane water channels that facilitate bi-directional passive movement of water, was investigated by immunohistochemistry in the uterine tube of pre-pubertal and adult Saanen goats (Capra hircus), comparing the different phases of the oestrous cycle. Regional morphology and secretory processes were markedly different during the goat oestrous cycle. The tested AQP molecules showed different expression patterns in comparison with already studied species. AQP1-immunoreactivity was evidenced at the endothelium of blood vessels and in nerve fibres, regardless of the tubal tract and cycle period. AQP4-immunoreactivity was shown on the lateral plasmalemma in the basal third of the epithelial cells at infundibulum and ampulla level in the cycling goats, more evidently during follicular than during luteal phase. No AQP4-immunoreactivity was noticed at the level of the isthmus region, regardless of the cycle phase. AQP5-immunoreactivity, localized at the apical surface of epithelial cells, increased from pre-puberty to adulthood. Thereafter, AQP5-immunoreactivity was prominent during the follicular phase, when it strongly decorated the apical plasmalemma of all epithelial cells at ampullary level. During luteal phase, immunoreactivity was discontinuous, being weak to strong at the apex of the secretory cells protruding into the lumen. In the isthmus region, the strongest AQP5-immunoreactivity was seen during follicular phase, with a clear localization in the apical plasmalemma of all the epithelial cells and also on the lateral plasmalemma. AQP2, 3 and 9 were undetectable all along the goat uterine tube. Likely, a collaboration of different AQP molecules sustains the fluid production in the goat uterine tube. AQP1-mediated transudation from the blood capillaries, together with permeation of the epithelium by AQP4 in the basal rim of the epithelial cells and final intervening of apical AQP5, could

  6. Impact of ACTH administration on the oviductal sperm reservoir in sows: the local endocrine environment and distribution of spermatozoa.

    Science.gov (United States)

    Brandt, Y; Lang, A; Madej, A; Rodriguez-Martinez, H; Einarsson, S

    2006-03-01

    The objective of the study was to investigate if short-term stress in sows (simulated by injections of synthetic adrenocorticotrophic hormone (ACTH)) during standing oestrus had a negative effect on the local environment in the utero-tubal junction (UTJ) and isthmus and the distribution of spermatozoa in these segments. Fourteen sows were monitored for ovulation using ultrasonography in two consecutive oestruses. The sows were fitted with jugular catheters and, from onset of the second oestrus, blood samples were collected every second hour. In the 2nd oestrus, seven sows were given ACTH every second hour, from the onset of standing oestrus until the sow ovulated (ACTH-group), whereas the other seven sows remained as controls (C-group) and were given NaCl solution. The sows were artificially inseminated 16-18 h before expected ovulation. Six hours after ovulation the sows were anaesthetised, and blood samples were repeatedly taken from veins draining the uterus and the UTJ-isthmus, respectively. This oviduct was thereafter removed and divided in four adjacent sections consisting of: (i) the UTJ, (ii) the first, and (iii) the second isthmus segment prior to (iv), the ampullary-isthmic junction (AIJ) and the ampulla. The three first-mentioned segments were flushed to retrieve spermatozoa, whereas the last one was flushed to collect oocytes/ova. The number of spermatozoa attached to the zona pellucida was counted. The concentrations of cortisol in jugular blood of the ACTH-group sows during the time of ACTH-injections were significantly higher than of the C-group sows (pAIJ. In conclusion, simulated stress induced by injections of ACTH during standing oestrus results in elevated concentrations of progesterone before ovulation and may interfere with the rise of progesterone after ovulation. However, ACTH-injections appeared to augment transport of spermatozoa through the female genital tract of pigs.

  7. Number of spermatozoa in the crypts of the sperm reservoir at about 24 h after a low-dose intrauterine and deep intrauterine insemination in sows.

    Science.gov (United States)

    Tummaruk, P; Tienthai, P

    2010-04-01

    The aim of this study was to investigate the number of spermatozoa in the crypts of the utero-tubal junction (UTJ) and the oviduct of sows approximately 24 h after intrauterine insemination (IUI) and deep intrauterine insemination (DIUI) and compared with that of conventional artificial insemination (AI). Fifteen crossbred Landrace x Yorkshire (LY) multiparous sows were used in the experiment. Transrectal ultrasonography was performed every 4 h to examine the time of ovulation in relation to oestrous behaviour. The sows were inseminated with a single dose of diluted fresh semen by the AI (n = 5), IUI (n = 5) and DIUI (n = 5) at approximately 6-8 h prior to the expected time of ovulation, during the second oestrus after weaning. The sperm dose contained 3000 x 10(6) spermatozoa in 100 ml for AI, 1,000 x 10(6) spermatozoa in 50 ml for IUI and 150 x 10(6) spermatozoa in 5 ml for DIUI. The sows were anaesthetized and ovario-hysterectomized approximately 24 h after insemination. The oviducts and the proximal part of the uterine horns (1 cm) on each side of the reproductive tracts were collected. The section was divided into four parts, i.e. UTJ, caudal isthmus, cranial isthmus and ampulla. The spermatozoa in the lumen in each part were flushed several times with phosphate buffer solution. After flushing, the UTJ and all parts of the oviducts were immersed in a 10% neutral buffered formalin solution. The UTJ and each part of the oviducts were cut into four equal parts and embedded in a paraffin block. The tissue sections were transversely sectioned to a thickness of 5 mum. Every fifth serial section was mounted and stained with haematoxylin and eosin. The total number of spermatozoa from 32 sections in each parts of the tissue (16 sections from the left side and 16 sections from the right side) was determined under light microscope. The results reveal that most of the spermatozoa in the histological section were located in groups in the epithelial crypts. The means of

  8. Amino acid composition of the bushcricket spermatophore and the function of courtship feeding: Variable composition suggests a dynamic role of the nuptial gift.

    Science.gov (United States)

    Jarrige, Alicia; Body, Mélanie; Giron, David; Greenfield, Michael D; Goubault, Marlène

    2015-11-01

    Nuptial gifts are packages of non-gametic material transferred by males to females at mating. These gifts are common in bushcrickets, where males produce a complex spermatophore consisting in a sperm-containing ampulla and an edible sperm-free spermatophylax. Two non-mutually exclusive hypotheses have been suggested to explain the function of the spermatophylax: the paternal investment hypothesis proposes that it represents a male nutritional investment in offspring; the mating effort hypothesis proposes that the spermatophylax maximizes the male's sperm transfer. Because gift production may represent significant energy expenditure, males are expected to adjust their investment relative to the perceived quality of the female. In this study, we first examined the free amino acid composition and protein-bound amino acid composition of the nuptial gift in the bushcricket, Ephippiger diurnus (Orthoptera: Tettigoniidae). Second, we investigated whether this composition was altered according to female age and body weight. Our study represents the first investigation of both free and protein-bound amino acid fractions of a bushcricket spermatophylax. We found that composition of the nuptial gift varied both qualitatively and quantitatively with respect to traits of the receiving female: older females received larger amounts of protein-bound amino acids (both essential and non-essential), less water and less free glycine. This result suggests that gift composition is highly labile in E. diurnus, and we propose that gift allocation might represent a form of cryptic male mate choice, allowing males to maximize their chances of paternity according to the risk of sperm competition that is associated with mate quality.

  9. Discrimination of suppurative cholangitis from nonsuppurative cholangitis with computed tomography (CT)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Nam Kyung [Department of Diagnostic Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, Busan 602-739 (Korea, Republic of); Kim, Suk [Department of Diagnostic Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, Busan 602-739 (Korea, Republic of)], E-mail: kimsuk@medigate.net; Lee, Jun Woo; Kim, Chang Won [Department of Diagnostic Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, Busan 602-739 (Korea, Republic of); Kim, Gwang Ha; Kang, Dae Hwan [Department of Gastrointestinal Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, Busan 602-739 (Korea, Republic of); Jo, Hong Jae [Department of Surgery, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Pusan National University, Busan 602-739 (Korea, Republic of)

    2009-03-15

    Purpose: Suppurative cholangitis is characterized by obstruction, inflammation, and pyogenic infection of the biliary tract. This disease represents a true emergency. The purpose of this study was to compare the computed tomography (CT) findings between acute calculous suppurative and nonsuppurative cholangitis and to determine if there are findings that assist in the differential diagnosis. Materials and methods: Fifteen patients with acute suppurative cholangitis were enrolled in this study. Findings at endoscopic retrograde cholangiopancreaticography (ERCP) were the standard of reference for suppurative cholangitis. To compare the findings of suppurative cholangitis with those of nonsuppurative cholangitis, 35 patients with nonsuppurative cholangitis were randomly selected. The following findings were evaluated: the presence of papillitis, the presence of stones in the ampulla, the presence of intrahepatic stones, the presence of early inhomogeneous enhancement of the liver, the degree of bile duct dilatation, the degree of bile duct wall thickening and presence of cholecystitis. Sensitivity and specificity for each of the individual findings were calculated. Statistical analyses were performed the Pearson {chi}{sup 2} test, Fisher's exact test and the Mann-Whitney U test. Results: Papillitis showed the highest specificity 86% with 60% sensitivity. Marked inhomogeneous enhancement of the liver during the arterial phase showed 80% specificity with 60% sensitivity. In multivariate logistic analysis, papillitis and marked early inhomogeneous enhancement of the liver were the most significant predictors of acute suppurative cholangitis. The combination of these two CT findings improved specificity (97% specificity) for the diagnosis of suppurative cholangitis. Conclusion: Papillitis and marked early inhomogeneous enhancement of the liver were found to be the most discriminative CT findings for the diagnosis of acute suppurative cholangitis and the

  10. Estradiol binding in different parts of the rabbit oviduct during egg transport.

    Science.gov (United States)

    Puri, R K; Roy, S K

    1981-10-01

    Binding of estradiol (E2) was determined in the nuclei and cytosols from ampullary (A), ampullary-isthmic junction (AIJ) and isthmic (I) segments of the rabbit Fallopian tube during the passage of the egg. In the estrus rabbits, low concentration of cytosol and high concentration of nuclear bindings in I was recorded in contrast to that of A. However AIJ had similar levels as that of A. Important alterations were recorded when binding of estradiol was compared at 12, 14, 24, 48, 70 and 144 h post coitum (p.c.). At 12 h the nuclear binding was decreased in all portions of the oviduct, while cytosol binding was increased. When ova are present in the ampulla (14 h p.c.) level of nuclear binding decreased while that of cytosol increased; but both types of bindings increased when eggs are normality in AIJ (24 h p.c.). The level of nuclear binding begins to increase in the isthmus reaching maximum at 48 h and then gradually declines at 70 h. The estradiol binding further declined in A and AIJ, but I showed no significant change at 144 h (the eggs being in uterus). In cytosol maximum binding was obtained at 70 h, thereafter the level in all portions recorded a decrease at 144 h p.c. On the basis of these findings it is concluded that there is some correlation between egg transport and different levels of estradiol binding in tubal segments. Increased influence of estradiol is required for the retention of egg at AIJ and also for the transport through the isthmus. However, a decrease in the level of the hormone would be necessary for the release of tubal lock at AIJ.

  11. Bad基因在黄体期绵羊生殖器官中表达的比较研究%The on comparison of expression of Bad gene in generative organ of sheep at luteal phase

    Institute of Scientific and Technical Information of China (English)

    葛晨霞; 王龙涛; 李向军; 贾博寅; 马磊; 姜怀志

    2011-01-01

    DUring luteal phase (LP) immunohistochemistry was used to confirm and locate apoptosis cells and to detect the expression of Bad in major reproductive organs (ovaries, oviduct and uterus) of Small-tails Han Sheep (SHS) and Suffolk Sheep (SS),which have high and low productivity,respectively. Bad gene was expressed in most of luteal cells. secretory cells and part of ciliated cell in fimbriaend of fallopian tube, ampullae and isthmusthe epithelia at luteal phase of submited positiveness, ciliated cell was stained strongly at luteal phase. The expression inten difference was unsharpness in different position of fimhriae tubae at contemporaneous. Staining was moderate with Bad positive cells in fimbriaend of fallopian tube,ampullae and isthmusthe epithelia. Staining was light with Bad positive cells in endometrial gland and endometrium cotyledon Average optical density and average positive area were measured by computator image analysis software in different of position between Small-tails Hah Sheep (SHS) and Suffolk Sheep (SS) but also had several visible differences in reproductive organs. The ratio of positive cells and AO of endometrium cotyledon stroma of SHS was higher significantly than SS in LP (P<0. 01). The result showed that the difference of apoptosis in reproductive organs and expression of Bad between SHS and SS maybe is agroundwork which result in of their differential productivity.%以黄体期小尾寒羊和萨福克羊为研究对象,采用免疫组织化学技术,针对Bad基因在母羊生殖器官卵巢,输卵管和子宫中的表达与定位进行初步研究,在卵巢中Bad基因均在多数黄体细胞中表达;在输卵管宫管结合部、峡部和壶腹部的分泌细胞Bad基因均有不同程度的表达,未发现纤毛细胞Bad阳性细胞;子宫内膜腺体小泡表达Bad阳性,子宫内膜子叶、基质的阳性细胞数极少,阳性细胞呈轻度着色,显弱阳性.利用计算机图像分析技术测量小尾寒羊和萨福克

  12. Oestrus synchronization treatment induces histomorphological changes on the uterine tube epithelium of the gilt.

    Science.gov (United States)

    Juárez-Mosqueda, M L; Anzaldúa Arce, S R; Palma Lara, I; García Dalmán, C; Cornejo Cortés, M A; Córdova Izquierdo, A; Villaseñor Gaona, H; Trujillo Ortega, M E

    2015-12-01

    The aim of this study was to determine the histomorphological changes that occurred in response to two treatments for oestrus synchronization in three different regions of the gilt's uterine tubes epithelium: the ampulla (AMP), ampulla-isthmic junction (AIJ) and isthmus (IST). Nine prepuberal gilts were divided into three groups (n = 3): (1) eCG 400 IU and hCG 200 IU (eCG/hCG), (2) progesterone agonist (P4) and (3) control group. The number of secretory cells (stained with periodic acid-Schiff reaction or PAS-positive cells) decreased in the AMP in the P4 treated group when compared to the control group, whereas, no difference was observed in the number of PAS-negative cells in the AMP of the three groups. A significant decrease in the number of PAS-positive cells was observed in the AIJ and IST of the P4 treated group when compared to the eCG/hCG and control groups. An increase in the number of PAS-negative cells was observed in the AIJ and IST in the P4 treated group. The epithelium height in the AMP and AIJ was increased in the eCG/hCG group when compared to the control and P4 groups. In this last group, we observed a reduced height compared with the other two groups for the AIJ. In the IST, there were no significant changes in the epithelium height of the control or the other two groups (eCG/hCG and P4). The epithelial cells of the P4 treated group had the least amount of cytoplasmic granules and the lowest intensity of PAS staining in the AMP, AIJ and IST. Animals treated with eCG/hCG showed an intermediate number of cytoplasmic granules and intensity in all regions evaluated. These data show that P4 treatment for synchronization induces a significant (P epithelium. Moreover, eCG/hCG treatment increased the height of the epithelium in the AMP and AIJ, while in this last region, the P4 treatment decreased the epithelium height. These results show that synchronization treatments with P4 and in a smaller proportion with eCG/hCG can modify the amount of PAS

  13. A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear.

    Directory of Open Access Journals (Sweden)

    Katherine L Hammond

    Full Text Available The Bone Morphogenetic Protein (BMP genes bmp2 and bmp4 are expressed in highly conserved patterns in the developing vertebrate inner ear. It has, however, proved difficult to elucidate the function of BMPs during ear development as mutations in these genes cause early embryonic lethality. Previous studies using conditional approaches in mouse and chicken have shown that Bmp4 has a role in semicircular canal and crista development, but there is currently no direct evidence for the role of Bmp2 in the developing inner ear.We have used an RNA rescue strategy to test the role of bmp2b in the zebrafish inner ear directly. Injection of bmp2b or smad5 mRNA into homozygous mutant swirl (bmp2b(-/- embryos rescues the early patterning defects in these mutants and the fish survive to adulthood. As injected RNA will only last, at most, for the first few days of embryogenesis, all later development occurs in the absence of bmp2b function. Although rescued swirl adult fish are viable, they have balance defects suggestive of vestibular dysfunction. Analysis of the inner ears of these fish reveals a total absence of semicircular canal ducts, structures involved in the detection of angular motion. All other regions of the ear, including the ampullae and cristae, are present and appear normal. Early stages of otic development in rescued swirl embryos are also normal.Our findings demonstrate a critical late role for bmp2b in the morphogenesis of semicircular canals in the zebrafish inner ear. This is the first demonstration of a developmental role for any gene during post-embryonic stages of otic morphogenesis in the zebrafish. Despite differences in the early stages of semicircular canal formation between zebrafish and amniotes, the role of Bmp2 in semicircular canal duct outgrowth is likely to be conserved between different vertebrate species.

  14. Potential for electropositive metal to reduce the interactions of Atlantic sturgeon with fishing gear.

    Science.gov (United States)

    Bouyoucos, Ian; Bushnell, Peter; Brill, Richard

    2014-02-01

    Atlantic sturgeon (Acipenser oxyrhynchus) populations have been declared either endangered or threatened under the U.S. Endangered Species Act. Effective measures to repel sturgeon from fishing gear would be beneficial to both fish and fishers because they could reduce both fishery-associated mortality and the need for seasonal and area closures of specific fisheries. Some chondrostean fishes (e.g., sturgeons and paddlefishes) can detect weak electric field gradients (possibly as low as 5 Μv/cm) due to arrays of electroreceptors (ampullae of Lorenzini) on their snout and gill covers. Weak electric fields, such as those produced by electropositive metals (typically mixtures of the lanthanide elements), could therefore potentially be used as a deterrent. To test this idea, we recorded the behavioral responses of juvenile Atlantic sturgeon (31-43 cm fork length) to electropositive metal (primarily a mixture of the lanthanide elements neodymium and praseodymium) both in the presence and absence of food stimuli. Trials were conducted in an approximately 2.5 m diameter × 0.3 m deep tank, and fish behaviors were recorded with an overhead digital video camera. Video records were subsequently digitized (x, y coordinate system), the distance between the fish and the electropositive metal calculated, and data summarized by compiling frequency distributions with 5-cm bins. Juvenile sturgeon showed clear avoidance of electropositive metal but only when food was present. On the basis of our results, we conclude that the electropositive metals, or other sources of weak electric fields, may eventually be used to reduce the interactions of Atlantic sturgeon with fishing gear, but further investigation is needed.

  15. Positron Emission Tomography with 2-Deoxy-2-[18F] Fluoro-DGlucose in the Detection of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas

    Directory of Open Access Journals (Sweden)

    Brian KP Goh

    2007-05-01

    Full Text Available A 79-year-old Indian male was admitted with upper abdominal discomfort of 1-year duration which was associated with loss of weight and appetite. Clinical examination of the abdomen did not reveal any palpable masses. Laboratory investigations including a complete blood count, liver function tests and serum amylase were unremarkable. Standard serum tumor markers were within normal limits: carbohydrate antigen (CA 19-9, 13.4 U/mL (reference range: 3-45 U/mL; carcinoembryonic antigen (CEA, 1.4 μg/L (reference range: 0.5-3.5 μg/L and alphafetoprotein, 1.3 μg/L (reference range: 1-10 μg/L. A contrast-enhanced computed tomographic (CT scan demonstrated a cystically dilated and tortuous pancreatic duct measuring 1.9 cm, suggestive of an intraductal papillary mucinous neoplasm (IPMN. The common bile duct was dilated up to the level of the ampulla and a 3.2x2.0 cm heterogeneous soft tissue mass was observed in the head of the pancreas which extended into the duodenum, suggestive of a malignant lesion (Images 1 and 2. Fusion positron emission tomography/computed tomography (PET/CT was subsequently performed with 12.7 mCi of 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG administered intravenously. A whole body PET/CT scan was performed 60 minutes later with CT data used for attenuation correction and anatomical correlation. This confirmed a metabolically active focus within the pancreatic head mass with a standard uptake value (SUVmax of 3.5 compatible with carcinoma (Image 3.

  16. Optimizing management of pancreaticopleural fistulas

    Institute of Scientific and Technical Information of China (English)

    Marek Wronski; Maciej Slodkowski; Wlodzimierz Cebulski; Daniel Moronczyk; Ireneusz W Krasnodebski

    2011-01-01

    AIM: To evaluate the management of pancreaticopleu ral fistulas involving early endoscopic instrumentation of the pancreatic duct.METHODS: Eight patients with a spontaneous pancre aticopleural fistula underwent endoscopic retrograde cholangiopancreatography (ERCP) with an intention to stent the site of a ductal disruption as the primary treatment. Imaging features and management were evaluated retrospectively and compared with outcome.RESULTS: In one case, the stent bridged the site of a ductal disruption. The fistula in this patient closed within 3 wk. The main pancreatic duct in this case appeared normal, except for a leak located in the body of the pancreas. In another patient, the papilla of Vater could not be found and cannulation of the pancreatic duct failed. This patient underwent surgical treatment. In the remaining 6 cases, it was impossible to insert a stent into the main pancreatic duct properly so as to cover the site of leakage or traverse a stenosis situated down stream to the fistula. The placement of the stent failedbecause intraductal stones (n = 2) and ductal strictures (n = 2) precluded its passage or the stent was too short to reach the fistula located in the distal part of the pan creas (n = 2). In 3 out of these 6 patients, the pancre aticopleural fistula closed on further medical treatment. In these cases, the main pancreatic duct was normal or only mildly dilated, and there was a leakage at the body/tail of the pancreas. In one of these 3 patients, additional percutaneous drainage of the peripancreatic fluid collections allowed better control of the leakage and facilitated resolution of the fistula. The remaining 3 patients had a tight stenosis of the main pancreatic duct resistible to dilatation and the stent could not be inserted across the stenosis. Subsequent conservative treatment proved unsuccessful in these patients. After a failed therapeutic ERCP, 3 patients in our series devel oped super infection of the pleural or peripancreatic

  17. Capsule endoscopy and push enteroscopy in the diagnosis of obscure gastrointestinal bleeding

    Institute of Scientific and Technical Information of China (English)

    戈之铮; 胡运彪; 萧树东

    2004-01-01

    Background In obscure gastrointestinal (GI) bleeding, it is often difficult to detect the bleeding sites located in the small bowel with conventional radiological, scintigraphic or angiographic techniques. Push enteroscopy and capsule endoscopy are currently considered to be the most effective diagnostic procedures. The aim of this study was to compare the detection rates between capsule endoscopy and push enteroscopy. Methods From May 2002 through January 2003, we prospectively examined by capsule endoscopy 39 patients with suspected small bowel diseases, in particular GI bleeding of unknown origin in Renji Hospital. Among them, 32 complained of obscure recurrent GI bleeding. Between January 1993 and October 1996, we used push enteroscopy on 36 patients who suffered from unexplained GI bleeding. All patients had prior normal results on gastroscopy, colonoscopy, small bowel barium radiography, scintigraphy and/or angiography. Results M2A capsule endoscopy disclosed abnormal small bowel findings in 26 (82%) out of 32 patients. Twenty-one of them had significant pathological findings explaining their clinical disorders. Diagnostic yield was therefore 66% (21 of 32 patients). Definite bleeding sites diagnosed by capsule endoscopy in 21 patients included angiodysplasia (8), inflammatory small-bowel (5), small-bowel polyps (4), gastrointestinal stromal tumour (2), carcinoid tumour and lipoma (1), and hemorrhagic gastritis (1). Push enteroscopy detected the definite sources of bleeding in 9 (25%) of the 36 patients. Patients with definite bleeding sources included angiodysplasias (2), leiomyosarcoma (2), leiomyoma (1), lymphoma (1), Crohn's disease (1), small-bowel polyps (1) and adenocarcinoma of ampulla (1). Suspected bleeding sources were shown by push enteroscopy in two additional patients (6%), and in other five patients (16%) by capsule endoscopy.Conclusions The present study of patients with obscure GI bleeding showed that capsule endoscopy significantly superior

  18. Size of the Ovulatory Follicle Dictates Spatial Differences in the Oviductal Transcriptome in Cattle

    Science.gov (United States)

    Gonella-Diaza, Angela María; da Silva Andrade, Sónia Cristina; Sponchiado, Mariana; Pugliesi, Guilherme; Mesquita, Fernando Silveira; Van Hoeck, Veerle; de Francisco Strefezzi, Ricardo; Gasparin, Gustavo R.; Coutinho, Luiz L.; Binelli, Mario

    2015-01-01

    In cattle, molecular control of oviduct receptivity to the embryo is poorly understood. Here, we used a bovine model for receptivity based on size of the pre-ovulatory follicle to compare oviductal global and candidate gene transcript abundance on day 4 of the estrous cycle. Growth of the pre-ovulatory follicle (POF) of Nelore (Bos indicus) cows was manipulated to produce two groups: large POF large corpus luteum (CL) group (LF-LCL; greater receptivity) and small POF-small CL group (SF-SCL). Oviductal samples were collected four days after GnRH-induced ovulation. Ampulla and isthmus transcriptome was obtained by RNA-seq, regional gene expression was assessed by qPCR, and PGR and ERa protein distribution was evaluated by immunohistochemistry. There was a greater abundance of PGR and ERa in the oviduct of LF-LCL animals thus indicating a greater availability of receptors and possibly sex steroids stimulated signaling in both regions. Transcriptomic profiles indicated a series of genes associated with functional characteristics of the oviduct that are regulated by the periovulatory sex steroid milieu and that potentially affect oviductal receptivity and early embryo development. They include tissue morphology changes (extra cellular matrix remodeling), cellular changes (proliferation), and secretion changes (growth factors, ions and metal transporters), and were enriched for the genes with increased expression in the LF-LCL group. In conclusion, differences in the periovulatory sex steroid milieu lead to different oviductal gene expression profiles that could modify the oviductal environment to affect embryo survival and development. PMID:26699362

  19. [Etiological factors of acute pancreatitis].

    Science.gov (United States)

    Spicák, J

    2002-09-01

    Acute pancreatitis develops immediately after the causative impulse, while chronic pancreatitis develops after the long-term action of the noxious agent. A typical representative of acute pancreatitis is biliary pancreatitis, chronic pancreatitis develops in alcoholism and has a long latency. As alcoholic pancreatitis is manifested at first as a rule by a potent attack, it is classified in this stage as acute pancreatitis. The most frequent etiological factors in our civilization are thus cholelithiasis and alcoholism (both account for 20-50% in different studies). The assumed pathogenetic principles in acute biliary pancreatitis are the common canal of both efferent ducts above the obturated papilla, duodenopancreatic reflux and intrapancreatic hypertension. A detailed interpretation is however lacking. The pathogenesis of alcoholic pancreatitis is more complicated. Among others some part is played by changes in the calcium concentration and fusion of cellular membranes. Idiopathic pancreatitis occurs in up to 10%, part of the are due to undiagnosed alcoholism and cholelithiasis. Other etiologies are exceptional. Similarly as in cholelithiasis pancreatitis develops also during other pathological processes in the area of the papilla of Vater such as dysfunction of the sphincter of Oddi, ampulloma and juxtapapillary diverticulum, it is however usually mild. The incidence of postoperative pancreatitis is declining. Its lethality is 30% and the diagnosis is difficult. In the pathogenesis changes of the ion concentration are involved, hypoxia and mechanical disorders of the integrity of the gland. Pancreatitis develops in association with other infections--frequently in mumps, rarely in hepatitis, tuberculosis, typhoid and mycoses. Viral pancreatitis is usually mild. In parasitoses pancreatitis develops due to a block of the papilla Vateri. In hyperparathyroidism chronic pancreatitis is more likely to develop, recent data are lacking. As to dyslipoproteinaemias

  20. Bad基因在小尾寒羊输卵管上皮组织的表达%Expression of Bad gene in uterine tubal epithelium of small-tails han sheep

    Institute of Scientific and Technical Information of China (English)

    葛晨霞; 王龙涛; 李向军; 姜怀志

    2011-01-01

    The expression level of gene Bad in uterine tubal epithelium was detected adopting immunohistochemistry stain.Average optical density and average positive area were measured by computator image analysis software in different position and different stage of genesial cycle,in order to analysis the expression of pro-apoptosis gene Bad in uterine tubal epithelium.The result showed that part of ciliated cells in fimbriaend of fallopian tube,ampullae and isthmusthe epithelia of follicular phase and luteal phase of submited positiveness were stained stronger at luteal phase than those at follicular phase.The expression difference was unsharp in different position of fimbriae tubae at contemporaneousness.The secretory cells were positive at follicular phase and luteal phase, different position had no difference at the same phase,therefor,staining was stronger at luteal phase than follicular phase in the same region.The difference of average optical density and positive area rate in ampullae and isthmus epithelia were unsharp(P>0.05) ,while significant difference between fimbriaend of fallopian tube and isthmus at luteal phase or at follicular phase(P<0.05).It was significant difference in average optical density and positive area rate in identity position at different phase(P<0.05).It is concluded that Bad expressed in oviduct epithelia of small tails han sheep could participate the regulation of cyclic variation of oviduct epithelia.%采用免疫组织化学方法检测小尾寒羊输卵管上皮组织中Bad基因的表达水平,利用计算机图像分析技术测量小尾寒羊生殖周期的不同阶段输卵管上皮组织Bad基因表达的平均光密度和平均阳性面积.结果显示,小尾寒羊输卵管伞部、壶腹部和峡部上皮组织中的部分纤毛细胞在卵泡期和黄体期呈阳性,黄体期纤毛细胞较卵泡期表达强.同时期各部位表达强度的差异不明显.黄体期和卵泡期的分泌细胞均呈阳性,同时期不同部

  1. Defecography of rectal wall prolapse conditions; Defecografia nelle malattie parietali del retto da prolasso

    Energy Technology Data Exchange (ETDEWEB)

    Salzano, A.; Muto, M.; De Rosa, A. [Azienda Sanitaria di Rilievo Nazionale A. Cardarelli, Naples (Italy). Servizio di Neuroradiologia; Ginolfi, F.; Carbone, M.; Amodio, F.; Rossi, E. [Naples Univ. Federico 2. (Italy). Ist. di Scienze Radiologiche; Tuccillo, M. [Azienda Sanitaria di Rilirvo Nazionale A. Cardarelli, Naples (Italy). 2. Servizio di Radiologia

    1999-06-01

    Pelvic floor and rectal prolapse conditions have greatly benefited by new imaging and instrumental diagnostic approaches, and especially defecography, for both pathophysiological interpretation and differential diagnosis. The authors investigated the efficacy of defecography in the assessment of rectal prolapse, and in particular the role of videproctography in diagnosis such dynamic disorders. The dynamic changes of ampulla are well depicted by videoproctography, which showed anorectum normalization and spontaneous reduction of invagination after intussusception. Defecography exhibited good capabilities in showing rectal wall function abnormalities. Finally, some features of videoproctography such as low radiation dose, non-invasiveness and ease of execution, make the examination acceptable to patients with anorectal disorders and for the follow-up of rectal prolapse. [Italian] Le malattie del pavimento pelvico e dei prolassi del retto hanno tratto numerosi vantaggi da nuovi approcci di diagnostica per immagini e strumentali, specialmente dall'esame defecografico, sia nell'interpretazione fisiopatologica che nella diagnostica differenziale dei disordini anorettali. Scopo del lavoro: valutare l'efficacia della metodica defecografica nel riconoscimento delle malattie da prolasso del retto e in particolare il ruolo svolto dalla videoproctografia nella documentazione diagnostica e nel definire i principali elementi semeiologici riscontrabili in tali malattie in modo dinamico. Le fasi dinamiche della valutazione morfologica e posizionale dell'ampolla rettale sono ben evidenti nella viedeoproctografia, che documenta dopo l'intussuscezione la normalizzazione del complesso anorettale e la riduzione spontanea dell'invaginazione parietale. In questo studio si sottolineano le possibilita' diagnostiche della defecografia integrata da videoproctografia nel riconoscimento delle malattie parietali funzionali del retto e alcune peculiarita

  2. Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin.

    Directory of Open Access Journals (Sweden)

    Hyoung-Mi Kim

    Full Text Available Loss-of-function mutations of SLC26A4/pendrin are among the most prevalent causes of deafness. Deafness and vestibular dysfunction in the corresponding mouse model, Slc26a4(-/-, are associated with an enlargement and acidification of the membranous labyrinth. Here we relate the onset of expression of the HCO(3 (- transporter pendrin to the luminal pH and to enlargement-associated epithelial cell stretching. We determined expression with immunocytochemistry, cell stretching by digital morphometry and pH with double-barreled ion-selective electrodes. Pendrin was first expressed in the endolymphatic sac at embryonic day (E 11.5, in the cochlear hook-region at E13.5, in the utricle and saccule at E14.5, in ampullae at E16.5, and in the upper turn of the cochlea at E17.5. Epithelial cell stretching in Slc26a4(-/- mice began at E14.5. pH changes occurred first in the cochlea at E15.5 and in the endolymphatic sac at E17.5. At postnatal day 2, stria vascularis, outer sulcus and Reissner's membrane epithelial cells, and utricular and saccular transitional cells were stretched, whereas sensory cells in the cochlea, utricle and saccule did not differ between Slc26a4(+/- and Slc26a4(-/- mice. Structural development of stria vascularis, including vascularization, was retarded in Slc26a4(-/- mice. In conclusion, the data demonstrate that the enlargement and stretching of non-sensory epithelial cells precedes luminal acidification in the cochlea and the endolymphatic sac. Stretching and luminal acidification may alter cell-to-cell communication and lead to the observed retarded development of stria vascularis, which may be an important step on the path to deafness in Slc26a4(-/- mice, and possibly in humans, lacking functional pendrin expression.

  3. Effects of contrast media on the hepato-pancreato-biliary system

    Institute of Scientific and Technical Information of China (English)

    Omer Topcu; Atilla Kurt; Isilay Nadir; Sema Arici; Ayhan Koyuncu; Cengiz Aydin

    2009-01-01

    AIM: To determine the effects of high osmolarity contrast media (HOCM) and iso-osmolar contrast media (CM) application, with or without pressure, on hepato-pancreato-biliary (HPB) system. METHODS: Sixty rats were divided into six equal groups as follows: Group 1: (0.9% NaCl, control), Group 2: (diatrizoate meglumine Na, ionic HOCM, Urographin~(R)), Group 3: (iodixanol, iso-osmolar nonionic CM, Visipaque~(R)); each of which was applied without pressure, whereas the animals of the remaining three groups (1p, 2p, 3p) were subjected to the same CM with pressure. We performed a duodenal puncture and introduced a catheter into the ampulla. After the catheterization, 0.2 mL CM or 0.9%NaCl was injected with or without pressure. Blood samples were taken for biochemical evaluations. The histopathological examinations of liver, common bile duct, and pancreas were performed. RESULTS: There were no significant differences between the six groups for blood amylase, alanine aminotransferases, aspartate aminotransferases, bilirubin levels ( P > 0.05). Alkaline phosphatase and γ glutamyl transaminase levels were higher ( P 0.05) between HOCM (2, 2p) and iso-osmolar CM (3, 3p) groups. Bile duct proliferation and regeneration in the Urographin(R) Groups (2, 2p) were significantly higher ( P 0.05) between the groups. Application of the CM with pressure did not cause additional damage to the HPB system. CONCLUSION: Iso-osmolar, non-ionic CM could be more reliable than the ionic HOCM, whereas the application of pressure during the CM application had no effect on the HPB system.

  4. Clincial analysis about the relative factors of ectopic pregnancy occurrence%异位妊娠发病相关因素的临床分析

    Institute of Scientific and Technical Information of China (English)

    叶凤霞

    2009-01-01

    Objective To analyze the relative factors of ectopic pregnancy occurrence to provide scientitfic evidence for the procreation health care work. Methods 240 cases of ectopic pregnancy were diagnosed in our hospital from December 2005 to December 2008. The mean age was 26 years with a range of 18~42 years. The position, occurrence rate, relative factors, and treatment of ectopic pregnancy were analyzed. Results The rate of ectopic pregnancy in the ampullae of oviduct was marked higher than that in the other part of oviduct (P0.05). Condusion The increased ectopic pregnancy occurrence was obviously related with pelvic inflammatory disease, abortion, IUD, and pathological change'in oviduct. Pelvic inflammatory disease, abortion his-tory and ectopic pregnancy history were the important factors.%目的 通过对异位妊娠发病的相关因素进行分析探讨,为生育健康保健工作提供科学依据.方法 2005年12月~2008年12月来我院就诊,经过相关检查确诊为畀位妊娠患者240例.对其发病部位、发生率、发病的相关因素、治疗方法等进行临床分析.结果 壶腹部妊娠较其他部位输卵管妊娠比例明显增高,P0.05.结论 异位妊娠发病率的增加与盆腔炎、流产、IUD、输卵管病理改变有明显的相关性,盆腔炎、流产史及异位妊娠史是重要因素.

  5. A Study of Technical Approach Methods to Transabdominal Ultrasonography of the Extrahepatic Bile Ducts and of Following Effects from the Scan Training

    Energy Technology Data Exchange (ETDEWEB)

    Lee, In Ja [Dept. of Radiological Technology, Dongnam Health College, Suwon (Korea, Republic of); Kang, Dae Hyun [Dept. of Diagnostic Radiology, Korea University Guro Hospital, Seoul (Korea, Republic of); Kim, Bo Young [Seoul Sansung Clinic, Seoul (Korea, Republic of)

    2008-06-15

    The purposes of this study are to analyze abnormal dilatation of the extrahepatic bile ducts by using transabdominal ultrasound, to confirm the existence of bile ducts diseases and their interrelationship, and for it to give a new theoretical basis for the technical access to extrahepatic bile ducts, upon which to analyze the ripple effects of the scan training. After teaching technical access process based on the new theory about extrahepatic bile duct to the thirty students who are studying ultrasonography, we allocated three hours per one student (30 mins 6 times) to focus on the training of scanning skill. Training has been performed by one-to-one method. For evaluation, all the students have to perform the scans on (1) confluence of the right and left hepatic ducts (extrahepatic bile ducts and cystic duct), (2) the suprapancreatic bile duct, (3) the intrapancreatic bile duct, (4) intrapapilla Duct, based on the clearly divided concept. The existing training and methods have had low confidency about transabdominal ultrasonography of the extrahepatic bile duct and had limitation with which they could image only the suprapancreatic bile duct. The evaluation after finishing the train based on the new theory, however, all the students (30 students) can access to (1) confluence of the right and left hepatic ducts(extrahepatic bile ducts and cystic duct), (2) the suprapancreatic bile duct objectively. 24 students can access to (3) the intrapancreatic bile duct and only one student can even make an image for (4) the intrapapilla Duct Though the evaluation on extrahepatic bile duct has to be performed with multi-sided method considering intrahepatic cause, bile duct cause and pathophysiological cause, only if we can image the extrahepatic bile duct to ampular of Vater objectively and confidently, we can greatly reduce invasive procedure such as ERCP, which is for the purpose of simple differential diagnosis and painful to the patients. Therefore if we concentrate on

  6. Microbiologically Influenced Corrosion of Pilings

    Science.gov (United States)

    2014-03-04

    reported in all climatic conditions on unprotectej suJ pilings m contact with saline water (ie scawater and hrackisli ’.vater’’ tliat is siibj^ct... Pilings 6. AUTHOR(S) Brenda J. Little and Richard I. Ray 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Research Laboratory...ACRONYM(S) ONR 11. SPONSOR/MONITOR’S REPORT NUMBER(S| 13. SUPPLEMENTARY NOTES Ao/£/o/3lz<l 14. ABSTRACT Sheet piles , used as retaining walls

  7. American Prometheus. The Triumph and Tragedy of J. Robert Oppenheimer. Biography; J. Robert Oppenheimer. Die Biographie

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Kai; Sherwin, Martin J.

    2009-07-01

    A definitive portrait of legendary scientist J. Robert Oppenheimer, the ''father'' of the atomic bomb, discusses his seminal role in the twentieth-century scientific world, as well as his lesser-known roles as family man, supposed communist, and head of Princeton's Institute for Advanced Studies. ''American Prometheus'' is a rich evocation of America in mid-century and a compelling portrait of scientist J. Robert Oppenheimer, a man shaped by its major events--the Depression, World War II, and the Cold War. (orig.) [German] J. Robert Oppenheimer (1904-1967), der ''Vater der Atombombe'', zaehlt zu den schillerndsten Figuren der juengeren Zeitgeschichte. Fuer ihre glaenzende Biographie des ''amerikanischen Prometheus'' erhielten der Journalist Kai Bird und der Historiker Martin J. Sherwin den Pulitzer-Preis. Exemplarisch lassen sie das Drama eines Forschers lebendig werden, der sich zwischen Erkenntnisdrang und ethischer Verantwortung entscheiden muss. Oppenheimer leitete das streng geheime Manhattan-Projekt in der Wueste von New Mexico, wo am 16. Juli 1945 die erste Atombombe gezuendet wurde. Kurz darauf starben in Hiroshima und Nagasaki mehr als 200 000 Menschen durch die neue ''Wunderwaffe'' - die Menschheit war ins Atomzeitalter eingetreten. Erschuettert von der Zerstoerungskraft seiner Schoepfung, engagierte sich Oppenheimer fortan gegen den Einsatz nuklearer Waffen. Das machte ihn im Amerika der McCarthy-Aera verdaechtig. Er geriet ins Visier des FBI, wurde als Spion der Sowjetunion verleumdet und musste den Staatsdienst quittieren. Sein Privatleben wurde an die Oeffentlichkeit gezerrt, seine Wohnung verwanzt, sein Telefon abgehoert. Erst 1963 rehabilitierte ihn Praesident Kennedy. Ueber dreissig Jahre hinweg haben die Autoren Interviews mit Oppenheimers Angehoerigen, Freunden und Kollegen gefuehrt, FBI-Akten gesichtet, Tonbaender von Reden und Verhoeren

  8. Diagnostic value of magnetic resonance cholangiopancreatography in low choledochal joint and its complications%MRCP对胆囊管低位汇合及其并发症的诊断价值

    Institute of Scientific and Technical Information of China (English)

    赵欣; 谢明; 陈竹卿; 王振山; 张书泽

    2015-01-01

    To investigate the diagnostic value of magnetic resonance cholangiopancreatography (MRCP) for di-agnosing low choledochal joint and its complications. MRCP results of 29 low choledochal joint patients con-firmed were analyzed retrospectively, and then compared with those by endoscopic retrograde cholaniopancreatography (ERCP). MRCP could display clearly the location of low choledochal joint, and the patients with complications involved 4 ones with cholecystolithiasis, 5 ones with cholangiolithiasis, 15 ones with cholecystolithiasis and cholangiolithi-asis, 3 ones with Mirizz syndrome, 2 ones with pancreatitis, 1 case with carcinoma of head of pancreas after cholecystec-tomy and 1 case of Vater ampullary carcinoma. Interoperative and ERCP findings proved that MRCP could be used for the diagnosis of low choledochal joint and its complications with no missed diagnosis. MRCP can be involved for the diagnosis of low choledochal joint and its complications, and thus can be used for preoperative planning and treat-ment of the complications.%目的:探讨磁共振胰胆管成像(magnetic resonance cholangiopancreatography,MRCP)对胆囊管低位汇合及其并发症的诊断价值。方法:回顾性分析29例MRCP检查发现的胆囊管低位汇合病例,与术中或内镜逆行胰胆管造影(endoscopic retrograde cholangiopancreatography,ERCP)检查结果相对照。结果:MRCP能清晰显示胆囊管汇入位置,并发症包括单纯胆囊结石4例,单纯胆管结石5例,胆囊及胆管均有结石15例,合并Mirizzi综合征3例,合并胰腺炎2例,胆囊切除术后患者合并胰头癌1例,合并乏特氏壶腹癌1例。对照术中或ERCP所见,MRCP术前检查胆囊管低位汇合及其并发症诊断符合率为100%。结论:MRCP可清晰显示胆囊管低位汇合及其并发症,能为术前制订手术方案及并发症处理提供重要信息。

  9. The modified ampullar approach for vestibular implant surgery: Feasibility and its first application in a human with a long-term vestibular loss

    Directory of Open Access Journals (Sweden)

    Raymond eVan De Berg

    2012-02-01

    Full Text Available Objective: To assess, for the first time in a human with a long-term vestibular loss, a modified approach to the ampullae and the feasibility of evoking a VOR by ampullar stimulation.Material and methods: Peroperative stimulation of the ampullae, using the ampullar approach, was performed under full anaesthesia during cochlear implantation in a 21-year old female patient, who had experienced bilateral vestibular areflexia and sensorineural hearing loss for almost twenty years. Results: The modified ampullar approach was performed successfully with as minimally invasive surgery as possible. Ampullar stimulation evoked eye movements containing vectors congruent with the stimulated canal. As expected, the preliminary electrophysiological data were influenced by the general anaesthesia, which resulted in current spread and reduced maximum amplitudes of eye movement. Nevertheless, they confirm the feasibility of ampullar stimulation.Conclusion: The modified ampullar approach provides safe access to the ampullae using as minimally invasive surgery as possible. For the first time in a human with long-term bilateral vestibular areflexia, it is shown that the VOR can be evoked by ampullar stimulation, even when there has been no vestibular function for almost twenty years. This approach should be considered in vestibular surgery, as it provides safe access to one of the most favourable stimulus locations for development of a vestibular implant.

  10. Digitalised endoscopic retrograde pancreatography (D-ERP): A comparison with ERCP

    Energy Technology Data Exchange (ETDEWEB)

    Soimakallio, S.; Pirinen, A.; Suhonen, M.

    1988-06-01

    Cannulation of the papilla of Vater was successful in 49 out of 65 cases (75.4%) and digital imaging of the pancreas in 38% of cases. Visualisation of the pancreatic duct with D-ERP was comparable to that of conventional ERCP. Absent or faint opacification of the parenchyma was seen in 39.5% of patients. Both methods were equally effective for the diagnosis of pancreatic tumours. D-ERP was better than ERCP for the diagnosis of chronic pancreatitis. Two patients (4.1%) had clinical evidence of mild acute pancreatitis following pancreatic duct injections.

  11. The effect of DDT and its metabolite (DDE) on prostaglandin secretion from epithelial cells and on contractions of the smooth muscle of the bovine oviduct in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Wrobel, Michal H.; Mlynarczuk, Jaroslaw; Kotwica, Jan, E-mail: janko@pan.olsztyn.pl

    2012-03-01

    The insecticide DDT and its metabolite (DDE), due to their lipolytic nature and resistance to biodegradation, are accumulated in the living tissues. In cows, DDT and DDE were found to affect prostaglandin (PG) secretion from the endometrium and contractions of the myometrium. In this study, the impact of both xenobiotics (0.1, 1, 10 or 100 ng/ml) on the function of epithelial cells and muscle strips of bovine oviducts from 1 to 5 day of the oestrous cycle was examined. Therefore the concentration of PGE2 and PGFM (a metabolite of PGF2α) in culture media, mRNA expression of genes involved in PGs synthesis in epithelial cells and the force and amplitude of strips contractions were measured after 2 and 24 or 48 h of incubation. Neither DDT nor DDE affected the viability of cells after 48 h (P > 0.05). Both DDT and DDE increased the concentrations of PGFM in culture medium and secretion of PGE2 after only 2 h of cell culture (P < 0.05). Similar effects were seen for the influence of DDE on amount of PGFM after 48 h, while DDT decreased secretion of PGE2 (P < 0.05). DDT after 2 h increased (P < 0.05) mRNA expression of PGF2α synthase (PGFS), while both xenobiotics decreased (P < 0.05) mRNA expression of cyclooxygenase-2 (COX-2) after 24 h. DTT also increased the force of isthmus contractions after 2 h, as did both xenobiotics after 48 h (P < 0.05). Moreover, after 2 and 48 h, DDE stimulated the amplitude of contractions of the isthmus as well as the ampulla, (P < 0.05). The effect of both compounds on oviduct contractions was diminished by indomethacin, which blocks PG synthesis. We conclude that oviductal secretion of prostaglandins is affected, by DDT and DDE. The influence of these xenobiotics on PGF2α and PGE2 secretion and ratio may be part of the mechanism by which both DDT and its metabolite disturb the contractions of oviductal muscle. -- Highlights: ► DDT and its metabolite – DDE are accumulated in the living tissues. ► The insecticides affected PGF2

  12. HIPOPLASIA DEL PULGAR: PRESENTACIÓN CLÍNICA Y RECONSTRUCCIÓN Hipoplasia of the thumb: Clinical presentation and reconstruction

    Directory of Open Access Journals (Sweden)

    Enrique M Vergara Amador

    2008-03-01

    ógicas o renales. Pacientes con deficiencia longitudinal del radio tienen peores resultados que los pacientes que tuvieron hipoplasia única del pulgar. En general los resultados fueron buenos y están de acuerdo con los reportes de la literatura donde escriben que el procedimiento ideal para la reconstrucción de un pulgar hipoplásico tipo IIIb, IV y V sigue siendo la pulgarización.Background. in the genesis of the partial or total absence of the thumb they are genetic, environmental factors or a combination of both. It is take part of a syndrome or to be isolated and frequently associated with problems of radial longitudinal deficiency of the forearm. Objective. The purpose of this study is mostar the experience, the focus of the processing and the results obtained since the point esthetic and functional view. The most it accepted classification is the proposal by Blauth that helps to determine the forecast and the processing. Materials and methods. it is a work type series of cases in 22 children with hipoplasia of the thumb, with a minimum of 12 months, (average 28 months. In 15 cases there were association of radial dysplasia or another anomaly among them 4 patients with VATER, and the 7 remaining they corresponded to hipoplasia of the thumb as only entity. We carried out tendon transfer, with opening of the first comisure in 2 patients with hipoplasia type II. In 3 patients, with hipoplasia type III A, one carries out corner opening, transfer of the superficial flexor of the 4 finger to correct instability of the articulation MF and opposition of the thumb, and transfer for extension of the thumb. In 17 cases one carries out pollicization of the index. Results. The outcome was evaluated in: non pinch, lateral pinch and fingertip pinch; the grade of opposition like good, minimal and non opposition, and the aesthetic result according to the satisfaction of the parents in bad, regular and good. The five children reconstructed with transfers of tendons and comisure

  13. 10955例经内镜逆行胰胆管造影术患者临床总结分析%Retrospective analysis of 10 955 cases of ERCP from a single endoscopy center

    Institute of Scientific and Technical Information of China (English)

    高飞; 麻树人; 张宁; 张迎春; 赵云峰; 高峰; 艾美娜; 杨卓; 宫照杰

    2013-01-01

    stone (40.85%),hilar bile duct carcinoma (10.53%),acute suppurative cholangitis (10.44%),cancer of head of pancreas (10.04%),chronic pancreatitis (8.24%),extrahepatic bile duct cancer (7.68%),periampullary cancer (6.96%),acute pancreatitis with bile duct stones (3.94%),benign stenosis of Vater's papilla (3.88%) and duodenal papillary cancer (3.50%).Extrahepatic bile duct stone,acute suppurative cholangitis and benign stenosis of Vater's papilla were more common in patients of 40-50 years old,and chronic pancreatitis was more often seen patients of 50-60 years old,while acute pancreatitis with bile duct stones,hilar bile duct carcinoma,extrahepatic bile duct cancer,cancer of head of pancreas,periampullary cancer,duodenal papillary cancer were more common in patients of 70-80 years old.In the recent 3 years,98.74% ERCP procedures was done under total intravenous anesthesia (TIVA).Conclusion ERCP is a key method for diagnosis and treatment of extrahepatic bile duct stone,acute suppurative cholangitis and malignant biliary obstructive disease,especially for extremely elderly patients.ERCP under total intravenous anesthesia is safe and effective.

  14. The effect of DDT and its metabolite (DDE) on prostaglandin secretion from epithelial cells and on contractions of the smooth muscle of the bovine oviduct in vitro.

    Science.gov (United States)

    Wrobel, Michal H; Mlynarczuk, Jaroslaw; Kotwica, Jan

    2012-03-01

    The insecticide DDT and its metabolite (DDE), due to their lipolytic nature and resistance to biodegradation, are accumulated in the living tissues. In cows, DDT and DDE were found to affect prostaglandin (PG) secretion from the endometrium and contractions of the myometrium. In this study, the impact of both xenobiotics (0.1, 1, 10 or 100ng/ml) on the function of epithelial cells and muscle strips of bovine oviducts from 1 to 5day of the oestrous cycle was examined. Therefore the concentration of PGE2 and PGFM (a metabolite of PGF2α) in culture media, mRNA expression of genes involved in PGs synthesis in epithelial cells and the force and amplitude of strips contractions were measured after 2 and 24 or 48h of incubation. Neither DDT nor DDE affected the viability of cells after 48h (P>0.05). Both DDT and DDE increased the concentrations of PGFM in culture medium and secretion of PGE2 after only 2h of cell culture (P<0.05). Similar effects were seen for the influence of DDE on amount of PGFM after 48h, while DDT decreased secretion of PGE2 (P<0.05). DDT after 2h increased (P<0.05) mRNA expression of PGF2α synthase (PGFS), while both xenobiotics decreased (P<0.05) mRNA expression of cyclooxygenase-2 (COX-2) after 24h. DTT also increased the force of isthmus contractions after 2h, as did both xenobiotics after 48h (P<0.05). Moreover, after 2 and 48h, DDE stimulated the amplitude of contractions of the isthmus as well as the ampulla, (P<0.05). The effect of both compounds on oviduct contractions was diminished by indomethacin, which blocks PG synthesis. We conclude that oviductal secretion of prostaglandins is affected, by DDT and DDE. The influence of these xenobiotics on PGF2α and PGE2 secretion and ratio may be part of the mechanism by which both DDT and its metabolite disturb the contractions of oviductal muscle.

  15. Comprehensive review of the anatomy and physiology of male ejaculation: Premature ejaculation is not a disease.

    Science.gov (United States)

    Puppo, Vincenzo; Puppo, Giulia

    2016-01-01

    Human semen contains spermatozoa secreted by the testes and a mixture of components produced by the bulbo-urethral and Littre (paraurethral) glands, prostate, seminal vesicles, ampulla, and epididymis. Ejaculation is used as a synonym for the external ejection of semen, but it comprises two phases: emission and expulsion. As semen collects in the prostatic urethra, the rapid preorgasmic distension of the urethral bulb is pathognomonic of impeding orgasm, and the man experiences a sensation that ejaculation is inevitable (in women, emission is the only phase of orgasm). The semen is propelled along the penile urethra mainly by the bulbocavernosus muscle. With Kegel exercises, it is possible to train the perineal muscles. Immediately after the expulsion phase the male enters a refractory period, a recovery time during which further orgasm or ejaculation is physiologically impossible. Age affects the recovery time: as a man grows older, the refractory period increases. Sexual medicine experts consider premature ejaculation only in the case of vaginal intercourse, but vaginal orgasm has no scientific basis, so the duration of intercourse is not important for a woman's orgasm. The key to female orgasm are the female erectile organs; vaginal orgasm, G-spot, G-spot amplification, clitoral bulbs, clitoris-urethra-vaginal complex, internal clitoris and female ejaculation are terms without scientific basis. Female sexual dysfunctions are popular because they are based on something that does not exist, i.e. the vaginal orgasm. The physiology of ejaculation and orgasm is not impaired in premature ejaculation: it is not a disease, and non-coital sexual acts after male ejaculation can be used to produce orgasm in women. Teenagers and men can understand their sexual responses by masturbation and learn ejaculatory control with the stop-start method and the squeeze technique. Premature ejaculation must not be classified as a male sexual dysfunction. It has become the center of a

  16. The Mecyclothorax beetles (Coleoptera, Carabidae, Moriomorphini of Tahiti, Society Islands

    Directory of Open Access Journals (Sweden)

    James Liebherr

    2013-08-01

    Full Text Available The 101 species of Mecyclothorax Sharp known to inhabit Tahiti Island, French Polynesia are taxonomically revised, including 28 species that are newly described: M. claridgeiae sp. n., M. jeanyvesi sp. n., M. poria sp. n., M. aano sp. n., M. papau sp. n., M. manina sp. n., M. everardi sp. n., M. ramagei sp. n., M. pitohitiensis sp. n., M. curtisi sp. n., M. hoeahiti sp. n., M. ninamu sp. n., M. kokone sp. n., M. paahonu sp. n., M. kayballae sp. n., M. ehu sp. n., M. papuhiti sp. n., M. tuea sp. n., M. taatitore sp. n., M. konemata sp. n., M. arboricola sp. n., M. rahimata sp. n., M. oaoa sp. n., M. maninapopoti sp. n., M. hunapopoti sp. n., M. fefemata sp. n., M. maninamata sp. n., and M. niho sp. n. Mecyclothorax muriauxioides Perrault, 1984 is newly synonymized with M. muriauxi Perrault, 1978. Lectotypes are designated for: Thriscothorax altiusculus Britton, 1938; T. bryobius Britton, 1938; Mecyclothorax globosus Britton, 1948: and M. sabulicola Britton, 1948. Dichotomous identification keys augmented by dorsal habitus and male aedeagal photographs are provided to the various species-groups and all included species. The spermatophore of M. papau sp. n. is described, with the ampulla and collar found to correspond dimensionally to the length of the internal sac flagellar plate. Variation among characters of the female reproductive tract is presented for all newly described plus other representative species comprising the radiation. Taxa are assigned to species groups, modified from the classification of G.G. Perrault, based on derived character states polarized using the Australian outgroup taxon Mecyclothorax punctipennis (MacLeay. Much of the species-level diversity on this small Pacific island is partitioned allopatrically over very small distributional ranges. No species is shared between Tahiti Nui and Tahiti Iti, and nearly all species in Tahiti Nui are geographically restricted to one ridgelike massif of that volcano. Cladistically

  17. Diagnostic and interventional radiology in the post-operative period and follow-up of patients after rectal resection with coloanal anastomosis

    Energy Technology Data Exchange (ETDEWEB)

    Severini, A.; Civelli, E.M.; Uslenghi, E.; Cozzi, G.; Salvetti, M.; Milella, M. [Department of Radiology, National Cancer Institute of Milan, via Venezian 1, I-23100 Milan (Italy); Gallino, G.; Bonfanti, G.; Belli, F.; Leo, E. [Department of Surgery, National Cancer Institute of Milan, via Venezian 1, I-23100 Milan (Italy)

    2000-07-01

    Surgical treatment of carcinoma of the distal third of the rectum with anal sphincter preservation is increasingly used in accredited cancer centers. This study aimed to evaluate the diagnostic usefulness of radiological investigations in the management of patients who had undergone resection with coloanal anastomosis for carcinoma of the rectum, in the immediate post-operative period, during closure of the protective colostomy and in the follow-up of symptomatic recanalized patients. A total of 175 patients who had undergone total rectal resection with end-to-side anastomosis for carcinoma of the distal third of the rectal ampulla, most of whom had received postoperative radiotherapy, were evaluated radiologically. In the postoperative period radiological investigation was ordered only for symptomatic patients to detect pathology of the anastomosis and the pouch sutures and was used direct film abdominal radiography and contrast-enhanced radiography of the rectal stump with a water-soluble radio-opaque agent. Before closure of the colostomy, 2 months after rectal excision or approximately 4 months after if postoperative radiotherapy was given, the anastomosis and pouch of all patients, even asymptomatic ones, were studied with water-soluble contrast enema to check for normal canalization. In the follow-up after recanalization radiological examinations were done to complete the study of the large intestine if the endoscopist was not able to examine it up to the cecum. Of the 175 patients examined radiologically during the postoperative period and/or subsequent follow-up, 95 showed no pathological findings. Seventy-nine patients had fistulas of the coloanal anastomosis or the pouch, 23 of which supplied a presacral collection. In the absence of severe sepsis, the only therapeutic measures were systemic antibiotics and washing of the surgical catheters to maintain efficient operation. In 2 patients in whom transanal drainage was performed radiologically the fistula

  18. Caspase-9在肉用绵羊主要生殖器官中的分布研究%Light Microscope Immunocytochemical Studies of the Distribution of Caspase-9 in the Reproductive Organs of Meat Sheep

    Institute of Scientific and Technical Information of China (English)

    张涛杰; 崔燕; 余四九; 樊江峰; 刘犇; 郑凯

    2011-01-01

    通过试验研究凋亡因子Caspase-9在肉用绵羊主要生殖器官中的表达,并探讨其生理意义.利用免疫组织化学的方法对Caspase-9在肉用绵羊主要生殖器官中的表达进行研究.研究结果显示,Caspase-9只在细胞质中表达,其在卵巢中主要分布于原始卵泡、初级卵泡及颗粒性黄体细胞,而卵泡膜性黄体细胞中未见表达;黄体期,主要表达于子宫的浅层腺体腺上皮细胞、子宫内膜上皮细胞、子宫颈黏膜固有层的淋巴小结、输卵管黏膜上皮分泌细胞和纤毛细胞、峡部的浆液性腺的腺上皮细胞;卵泡期,子宫和输卵管各个部位阳性反应不明显.在正常生理情况下,Caspase-9参与了肉用绵羊主要生殖器官周期性变化的调控和子宫黏膜免疫,对生殖器官功能的稳定发挥起着重要作用.%The expression of the apoptotic gene caspase-9 in the reproductive organs of meat sheep was observed and its physiological significance was determined by using immunohistochemistric technology. Caspase-9 was only found in the cytoplasm. The majority of positive cells in the ovary were observed in primordial and primary follicles. In the later luteal phase, Caspase-9 was positive in granular lutein cells but negative in theca lutein cells; during the luteal phase, Caspase-9 was positive in endometrial epithelium and shallow glands of the oviduct, the lymphatic nodule of the cercix uteri, the ciliated cell and secretory cell of the mucous epithelium in ampulla tubae uterinae ,and the epithelium of serous gland of the tubal isthmus; during the follicular phase, no obvious positive expression was found. All results mentioned above indicate that Caspase-9 participate in the regulation of apoptosis and immunological tissue of the major reproductive organs of meat sheep. It is important for the stability of reproductive organs in meat sheep.

  19. The Expression and Change of the β3 Integrin Subunit and Fibronectin in Normal Human Oviductal Tissue and Tubal Ectopic Pregnant Tissue

    Institute of Scientific and Technical Information of China (English)

    Chun-jie MA; Wei-jie ZHU; Hai-yan JIN; Guang-yu JIANG; Hong SHEN; Hong LI; Ming-han XIA

    2003-01-01

    Objective To investigate the expression and change of the β3 integrin subunit and fibronectin in normal human oviductal tissue during various phases of the menstrual cycle and tubal ectopic pregnant tissue Methods Samples of normal ( n=29 ) and pregnant fallopian tube ( n=22 ) tissues were obtained from women who had normal cycle and history of normal pregnancy. Normal oviductal tissue samples were divided into 4 groups based on their menstrual cycle.Both expression and distribution of the β3 subunit and fibronectin were determined with the immunohistochemical method and the image analysis.Results The β3 subunit was expressed in the cytoplasm of ciliated cells. The expression level of the β3 subunit was higher after ovulation than that before ovulation in isthmus epithelium (P <0.001), and declined significantly after ovulation in ampullae epithelium (P<0. 001). In umbrella epithelium within 4 days after ovulation, the expression level of the β3 subunit was observed at rather higher level among other phases (P <0.001). The ciliated and secretory cells of the epithelium except for where the pregnancy occurred in tubal pregnancy expressed the β3 subunit, and no significant relationship was found between the normal tubal tissue of the secretory phase and tubal ectopic pregnant tissue (P>0. 05). Fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. The expression level of fibronectin was higher in the hyperplastic phase than that in the secretory one (P <0. 001). And it was lower in normal tubal tissue of the secretory phase than that in tubal ectopic pregnant tissue (P <0.001).Conclusion The β3 integrin subunit was expressed in the ciliated cells of human oviductal epithelium, and fibronectin was expressed in the basement membrane of human oviductal epithelium and matrix. Their expression and change in oviductal tissue is based on different phases of menstrual cycle. Theβ3 subunit could not related to the

  20. Study of responsible arteries of duodenal ulcer hemorrhage and the significance of transcatheter arterial embolization%十二指肠溃疡出血责任动脉的研究及在栓塞治疗中的意义

    Institute of Scientific and Technical Information of China (English)

    李强; 吴亮; 汤继军

    2014-01-01

    Objective To study the responsible arteries of duodenal ulcer hemorrhage and the significance of transcatheter arterial embolization.Methods There were 1 7 patients of massive bleeding of duodenal ulcer,in which 1 6 patients were diagnosed and 8 ca-ses were treated by endoscope initially.DSAs were performed at gastr-oduodenal arteries or their ramus in all patients.DSA signs were analysed by two salted docters together.At first the responsible ar-teries for duodenal ulcer hemorrhage were affirmed,and then endo-vascular embolization was performed.Results The responsible arteries for duodenal ampulla ulcer hemorrhage were the ascending duodenal artery(ADA)、the pancreaticoduodenal trunk(PDT)、the supraduodenal artery(SDA)and the retroduodenal artery (RDA).The responsible arteries for descendant duodenum ulcer hemorrhage were the anterior superior pancreaticoduodenal artery (ASPDA)and the posterior superior pancreaticoduodenal artery(PSPDA).The positive rate of bleeding that showed the signs of bleeding was 100%,the s-uccess rate of the operations was 100%,the complete efficiency ra-te of hemostasis was 88.2%,the par-tial efficiency rate of hemostas was 1 1.8%.Conclusion The responsible arteries of duodenal ulcer hemorrhage are multiples,which is important for guiding transcatheter arterial embolization of the responsible arteries of duodenal ulcer hemorrhage accurately.%目的:探讨十二指肠溃疡出血的责任动脉及在栓塞治疗中的意义。方法17例十二指肠溃疡大出血患者,分析其 DSA表现,判定出血的责任动脉,然后实施栓塞治疗。结果十二指肠球部溃疡出血的责任动脉为十二指肠升动脉(ADA)、十二指肠胰干(PDT)、十二指肠上动脉(SDA)、十二指肠后动脉(RDA),十二指肠降部溃疡出血的责任动脉为胰十二指肠上前动脉(ASPDA)和胰十二指肠上后动脉(PSPDA)。结论十二指肠溃疡出血的责任动脉众多,准确判定十二指肠溃疡出血的责任动

  1. A study on the changing of the irradiated mice salivary glands and it's influence to the pancreas

    Energy Technology Data Exchange (ETDEWEB)

    Funahara, Takayuki; Nasu, Masanori; Furumoto, Keiichi (Nippon Dental Univ., Tokyo (Japan))

    1991-02-01

    X-ray irradiation (10 Gy) was given to the salivary gland in mice. Protein and glycoprotein syntheses in the salivary glands and pancreas were examined by using {sup 3}H-leucine and {sup 14}C-acetylglucosamine as tracers. Quantitative analysis of serum amylase and histochemical examination were also conducted. Uptake of {sup 3}H-leucine was low in the parotid, submandibular, and sublingual glands 3 and 7 days after irradiation, which were close to those in the non-irradiated group 21 days after irradiation. Uptake of {sup 14}C-acetylglucosamine in the parotid, submandibular, and sublingual glands varied with time, which was similar to that of {sup 3}H-leucine uptake. The uptake of both {sup 14}C-acetylglucosamine and {sup 3}H-leucine in the pancreas, as opposed to that in the salivary glands, varied with time, with the highest levels on Days 3 and 7, respectively. Serum amylase level, determined by the maltopentaose method, was 5,341+-772 mU/ml in the non-irradiated group. On Day 3, it was 6,706+-583 mU/ml. This was slightly higher than the level in the non-irradiated group on Days 7 and 21, with no statistically significant difference. Hematoxylin-eosin staining revealed hypertrophy of the glandular cells on Day 3, atrophy of the glandular cells on Day 7, and irregular cell arrangement on Day 21 for the parotid gland; and atrophied granular ampulla on Day 3, and hypertrophy on Day 7 for the submandibular gland. No marked changes were observed in either the sublingual gland or pancreas. Ninhydrin staining revealed a decreased stainability in the submandibular gland on Day 3; and an increased stainability in the pancreas on Day 7. In conclusion, protein and glycoprotein syntheses in the salivary glands after X-ray irradiation of 10 Gy decreased on Days 3 and 7, respectively. This seemed to be associated with compensatory function of the pancreas. (N.K.).

  2. Magnetic field effects on the vestibular system: calculation of the pressure on the cupula due to ionic current-induced Lorentz force

    Science.gov (United States)

    Antunes, A.; Glover, P. M.; Li, Y.; Mian, O. S.; Day, B. L.

    2012-07-01

    Large static magnetic fields may be employed in magnetic resonance imaging (MRI). At high magnetic field strengths (usually from about 3 T and above) it is possible for humans to perceive a number of effects. One such effect is mild vertigo. Recently, Roberts et al (2011 Current Biology 21 1635-40) proposed a Lorentz-force mechanism resulting from the ionic currents occurring naturally in the endolymph of the vestibular system. In the present work a more detailed calculation of the forces and resulting pressures in the vestibular system is carried out using a numerical model. Firstly, realistic 3D finite element conductivity and fluid maps of the utricle and a single semi-circular canal containing the current sources (dark cells) and sinks (hair cells) of the utricle and ampulla were constructed. Secondly, the electrical current densities in the fluid are calculated. Thirdly, the developed Lorentz force is used directly in the Navier-Stokes equation and the trans-cupular pressure is computed. Since the driving force field is relatively large in comparison with the advective acceleration, we demonstrate that it is possible to perform an approximation in the Navier-Stokes equations that reduces the problem to solving a simpler Poisson equation. This simplification allows rapid and easy calculation for many different directions of applied magnetic field. At 7 T a maximum cupula pressure difference of 1.6 mPa was calculated for the combined ampullar (0.7 µA) and utricular (3.31 µA) distributed current sources, assuming a hair-cell resting current of 100 pA per unit. These pressure values are up to an order of magnitude lower than those proposed by Roberts et al using a simplistic model and calculation, and are in good agreement with the estimated pressure values for nystagmus velocities in caloric experiments. This modeling work supports the hypothesis that the Lorentz force mechanism is a significant contributor to the perception of magnetic field induced vertigo.

  3. Magnetic field effects on the vestibular system: calculation of the pressure on the cupula due to ionic current-induced Lorentz force.

    Science.gov (United States)

    Antunes, A; Glover, P M; Li, Y; Mian, O S; Day, B L

    2012-07-21

    Large static magnetic fields may be employed in magnetic resonance imaging (MRI). At high magnetic field strengths (usually from about 3 T and above) it is possible for humans to perceive a number of effects. One such effect is mild vertigo. Recently, Roberts et al (2011 Current Biology 21 1635-40) proposed a Lorentz-force mechanism resulting from the ionic currents occurring naturally in the endolymph of the vestibular system. In the present work a more detailed calculation of the forces and resulting pressures in the vestibular system is carried out using a numerical model. Firstly, realistic 3D finite element conductivity and fluid maps of the utricle and a single semi-circular canal containing the current sources (dark cells) and sinks (hair cells) of the utricle and ampulla were constructed. Secondly, the electrical current densities in the fluid are calculated. Thirdly, the developed Lorentz force is used directly in the Navier-Stokes equation and the trans-cupular pressure is computed. Since the driving force field is relatively large in comparison with the advective acceleration, we demonstrate that it is possible to perform an approximation in the Navier-Stokes equations that reduces the problem to solving a simpler Poisson equation. This simplification allows rapid and easy calculation for many different directions of applied magnetic field. At 7 T a maximum cupula pressure difference of 1.6 mPa was calculated for the combined ampullar (0.7 µA) and utricular (3.31 µA) distributed current sources, assuming a hair-cell resting current of 100 pA per unit. These pressure values are up to an order of magnitude lower than those proposed by Roberts et al using a simplistic model and calculation, and are in good agreement with the estimated pressure values for nystagmus velocities in caloric experiments. This modeling work supports the hypothesis that the Lorentz force mechanism is a significant contributor to the perception of magnetic field induced vertigo.

  4. Cryptosporidium spp. infection in mares and foals of the northwest region of São Paulo State, Brazil Infecção por Cryptosporidium spp. em éguas e potros da região noroeste do estado de São Paulo, Brasil

    Directory of Open Access Journals (Sweden)

    Sandra Valéria Inácio

    2012-12-01

    Full Text Available The present study aimed to analyze the occurrence of infection by Cryptosporidium spp. in mares and their respective foals. This study was carried out in 11 farms located in the municipalities of Araçatuba, Birigui, Guararapes and Santo Antônio do Aracangua, in the northwest region of the State of Sao Paulo, from November 2010 to March 2011. A total of 98 mares and 98 foals of several breeds were analyzed; among foals, 59 were males and 39 females, aged from three to 330 days. Feces were collected directly from the rectal ampulla, purified and processed according to modified Kinyoun stain. Occurrence of Cryptosporidium spp. was 21.4% (21/98 for foals and 18.4% (18/98 for mares. Occurrence of Cryptosporidium spp. had significant association with breeds and age of animals. Results obtained led to the conclusion that foals older than two months and Mangalarga animals are less susceptible to the occurrence of Cryptosporidium spp.O presente estudo teve como objetivo analisar a ocorrência da infecção por Cryptosporidium spp. em éguas e seus respectivos potros. Este estudo foi realizado em 11 fazendas localizadas nos municípios de Araçatuba, Birigui, Guararapes e Santo Antônio do Aracangua, na região Noroeste do Estado de São Paulo, de novembro de 2010 a março de 2011. Um total de 98 éguas e 98 potros de diversas raças foram analisados, sendo que, entre os filhotes, 59 eram machos e 39 fêmeas, cujas idades variavam de três até 330 dias. Fezes foram colhidas diretamente da ampola retal, purificadas e processadas pela técnica de Kinyoun modificada. A ocorrência de Cryptosporidium spp. observada foi de 21,4% (21/98 para potros e 18,4% (18/98 para éguas. A ocorrência de Cryptosporidium spp. teve uma associação significativa com a raça e a idade dos animais. A partir dos resultados obtidos, conclui-se neste estudo que potros com idade superior a dois meses e animais da raça Mangalarga foram menos susceptíveis à ocorrência de

  5. Clinical Value of Magnetic Resonance Imaging Dynamic Enhanced Scan and Magnetic Resonance Cholangiopancreatography for the Diagnosis of Biliary Obstruction%MRI动态增强扫描联合磁共振胰胆管造影在胆道梗阻性疾病诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    韩波

    2012-01-01

    Objective To investigate the value of magnetic resonance imaging dynamic enhanced scan ( LAVA ) combined with magnetic resonance cholangiopancreatography ( MRCP ) in the diagnosis of biliary obstruction. Methods 40 patients with obstructive jaundice admitted to our hospital from July 2010 and May 2011 were tested with MRI and MRCP. The imaging features of benign and malignant diseases were analyzed retrospectively. Results Among the 40 patients, there were 13 patients with distal bile duct carcinoma, 5 patients with hilar bile duct carcinoma, 4 patients with pancreas head carcinoma, 2 patients with duodenal carcinoma, 1 patient with ampulla carcinoma, 1 patient with duodenal diverticulitis, 12 patients with gallstone and 2 patients with IPMN. Conclusion MRI and MRCP could definitely demonstrate the biliary obstruction disease. The imaging results play an important role in differential diagnosis and in estimating the level of the process as well as guiding the treatment.%目的 探讨MRI动态增强扫描(LAVA)联合磁共振胰胆管造影(MRCP)对胆道梗阻性疾病的诊断价值.方法 选取2010-07-01-2011-05-01我院收治的40例梗阻性黄疸患者,均行LAVA、MRCP检查,对良恶性胆道梗阻的LAVA、MRCP影像学特征进行回顾性分析.结果 LAVA、MRCP检查显示:40例梗阻性黄疸患者中,末端胆管癌13例,肝门胆管癌5例,胰头癌4例,十二指肠癌2例,壶腹癌1例,十二指肠憩室炎1例,胆管结石12例,胰腺导管内乳头状黏液瘤2例.结论 LAVA和MRCP的联合应用对胆道梗阻性疾病的鉴别诊断具有重要价值,其影像学结果对临床治疗决策有指导意义.

  6. Oviduct fluid pH in intact and unilaterally ovariectomized pigs.

    Science.gov (United States)

    Nichol, R; Hunter, R H; Cooke, G M

    1997-09-01

    The pH of the oviduct lumen was measured at different stages of the estrous cycle in the ampulla and ampullary-isthmic junction (AIJ) of intact and unilaterally ovariectomized mated or nonmated pigs. The pH profile consisted of high frequency small peaks superimposed on low frequency large amplitude peaks. One animal examined at midcycle exhibited fluctuations in pH (peak to nadir; delta pH) of 0.3 and 0.7 units in the ampulla and AIJ, respectively, and the frequencies of the large peaks in these regions were 2.6 and 1.6 peaks.min-1, respectively. In six preovulatory unmated pigs, the delta pH (mean +/- SE) was 0.50 +/- 0.04 units in both regions and the large peak frequencies were 0.6 +/- 0.06 peaks.min-1. In one animal that was assessed during ovulation, the pH showed deviations of up to 0.4 pH units, which were probably due to the alkalinity of follicular fluid accompanying the ovulated eggs. In the ampullae of five unilaterally ovariectomized postovulatory-mated pigs, the delta pH in oviducts with and without an ipsilateral ovary was significantly lower than preovulatory (p AIJ with an ipsilateral ovary (0.11 +/- 0.02 units) was significantly lower than before ovulation (0.54 +/- 0.04 units) and also when compared with the contralateral AIJ (0.36 +/- 0.06 units) (p < 0.05). The ovary also influenced the small peak frequency, which was significantly higher if the ipsilateral ovary was absent (10.7 +/- 1.5 vs. 14.9 +/- 1.6 peaks.min-1, respectively). Thus, oviduct fluid pH is controlled by both systemic and local mechanisms, and the ipsilateral ovary and (or) embryonic factors influence the pH profile of the oviduct.

  7. [Intraductal papillary mucinous tumor: diagnostic and therapeutic approach].

    Science.gov (United States)

    Seijo Ríos, Susana; Lariño Noia, José; Iglesias García, Julio; Lozano León, Antonio; Domínguez Muñoz, Juan Enrique

    2008-02-01

    Primary cystic pancreatic neoplasms are rare tumors, with an approximate prevalence of 10% of cystic pancreatic lesions. Most of these lesions correspond to mucinous cystic neoplasm, serous cystoadenoma and intraductal papillary mucinous tumor (IPMT). IPMT is characterized by diffuse dilatation of the main pancreatic duct and/or side branches with inner defects related to mucin or tumor, or mucin extrusion from a patent ampulla. IPMT has a low potential for malignancy, with a low growth rate, a low rate of metastatic spread and postsurgical recurrence. Over the last few years, major advances have been made in the diagnostic and therapeutic management of this tumor.

  8. Tricks and tips in pancreatoduodenectomy

    Institute of Scientific and Technical Information of China (English)

    Anna; Pallisera; Rafael; Morales; Jose; Manuel; Ramia

    2014-01-01

    Pancreaticoduodenectomy(PD) is the standard surgical treatment for tumors of the pancreatic head, proximal bile duct, duodenum and ampulla, and represents the only hope of cure in cases of malignancy. Since its initial description in 1935 by Whipple et al, this complex surgical technique has evolved and undergone several modifications. We review three key issues in PD:(1) the initial approach to the superior mesenteric artery, known as the artery-first approach;(2) arterial complications caused by anatomic variants of the hepatic artery or celiac artery stenosis; and(3) the extent of lymphadenectomy.

  9. New Eclipidrilus species (Annelida, Clitellata, Lumbriculidae) from southeastern North America

    Science.gov (United States)

    Fend, Steven V.; Lenat, David R.

    2012-01-01

    Three new species of Lumbriculidae from southeastern North America are attributed to Eclipidrilus Eisen. All are small worms (diameter 0.2–0.5 mm), having semi-prosoporous male ducts with the atria in X, and spermathecae in IX. Eclipidrilus breviatriatus n. sp. and E. microthecus n. sp. have crosshatched atrial musculature, similar to some E. (Eclipidrilus) species, but they differ from congeners in having small, compact spermathecal ampullae. Eclipidrilus macphersonae n. sp. has a single, median atrium and spermatheca. The new species have been collected only in Sandhills and Middle Atlantic Coastal Plain streams of North Carolina.

  10. Diagnosis and management of intraductal papillary mucinous neoplasm in pancreas(IPMN)by endoscopy%内镜诊治胰腺导管内乳头状粘液性肿瘤的应用

    Institute of Scientific and Technical Information of China (English)

    杨蕾; 张斌; 李长铧; 邱云峰; 刘洋

    2012-01-01

    目的 探讨胰腺导管内乳头状粘液性肿瘤(IPMN)的诊断、内镜下治疗,以提高对该疾病的认识及内镜对其诊断及治疗的意义.方法 回顾性分析经内镜诊治的IPMN患者12例,总结并分析他们的一般情况、临床症状、影像学检查、实验室检查、内镜下治疗等方面资料.结果 12例IPMN患者以老年男性为主,无特异性临床表现,主要发生部位为胰头或钩突部,CT主要表现为囊实性低密度影,其内可有壁结节,胰管扩张伴或不伴胆管扩张,2例侵及胰腺实质.磁共振胰胆管造影(MRCP)主要表现为胰管扩张,胰腺萎缩,胰头部圆形高信号影.内镜下逆行胰胆管造影(ERCP)显示十二指肠乳头膨大,开口扩张,可见胶冻样粘液流出,胰管造影显示胰管全程扩张或胰头部囊状扩张,3例伴胆总管、肝内胆管扩张.9例行ERCP治疗,清除粘液栓并置入胰管支架,3例同时置入胆管支架.结论 IPMN是一种特殊类型的胰腺囊性疾病,影像学检查有其独特的表现,ERCP对其诊断及治疗有重要意义.%Objective To study the clinical diagnosis and treatment of intraductal papillary mucinous neoplasm in pancreas ( IPMN ) and evaluate the role of endoscopy in diagnosis and treatment. Methods The data of 12 patients with IPMN including general state of health, clinical characteristic of imaging findings, treatment by ERCP were retrospectively reviewed. Results This group is mainly of old men and no specific clinical information. CT demonstrated the cystic and solid lesion in the head or uncinate process of pancreas with mural nodules and dilatation of pancreatic duct. MRCP showed dilatation of pancreatic duct, high signal in the head of pancreas and atrophy of pancreas. ERCP was performed in all patients and found an abnormal protruding papilla of Vater with expulsion of mucous material, of whom 3 cases with dilatation of main pancreatic duct, 5 cases with cystic dilatation of head pancreatic duct, 3

  11. Letter to the Editor

    Directory of Open Access Journals (Sweden)

    Paula Hurtado

    2010-06-01

    Full Text Available Given the academic spirit of Colombia Médica, let us make some comments on the article «Unilateral renal agenesis: case review of ambulatory pediatric nephrology clinics in Cali, by Dr. Consuelo Restrepo de Rovetto et al.1 As for the assertion «There are no national or local statistics in Colombia to know the frequency, clinical aspects and complications of this anomaly» even when it is true that in our country there is little information on the epidemiological behavior of this type of pathology, we have found in the literature two articles: one published by Zarante et al. in Biomédica in 2010 (published online since 01.09.09, which mentions a prevalence of unilateral renal agenesis of 0.94 per 10,000, in the evaluation of 52,744 births in four Colombian cities2. Another article published by García et al.3 in the same journal in 2003, reported a prevalence of unilateral agenesis or kidney dysplasia of 1.76 per 10,000 births in the evaluation of 5686 births in Bogotá. Additionally, in the results section «Single kidney associated to other pathologies was found in 46.5% cases: occult spina bifida and congenital scoliosis, three cases; anorectal malformations, 3 cases; chromosome syndromes, 2 cases; Klippel-Feil syndrome, two cases; cryptorchidie, 1 case; tricuspid insufficiency, 1 case; pre-auricular appendix in 1 case, and a case of morbid obesity.  No patient with myeloid-Vater sequence or meningocele was found», which states that no patients were found with a diagnosis of Vater sequence. We would like to clarify that the term Vater sequence is currently not appropriate and it has been replaced by the term VACTERL association from the acronym vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal malformations, and limb defects4. The term association refers to «the occurrence of multiple idiopathic congenital malformations during blastogenesis»5. Given this definition, and knowing that there are no

  12. CORRESPONDENCIA

    Directory of Open Access Journals (Sweden)

    Consuelo Restrepo

    2010-06-01

    Full Text Available Letter to the Editor:Given the academic spirit of Colombia Médica, let us make some comments on the article «Unilateral renal agenesis: case review of ambulatory pediatric nephrology clinics in Cali, by Dr. Consuelo Restrepo de Rovetto et al.1As for the assertion «There are no national or local statistics in Colombia to know the frequency, clinical aspects and complications of this anomaly» even when it is true that in our country there is little information on the epidemiological behavior of this type of pathology, we have found in the literature two articles: one published by Zarante et al. in Biomédica in 2010 (published online since 01.09.09, which mentions a prevalence of unilateral renal agenesis of 0.94 per 10,000, in the evaluation of 52,744 births in four Colombian cities2. Another article published by García et al.3 in the same journal in 2003, reported a prevalence of unilateral agenesis or kidney dysplasia of 1.76 per 10,000 births in the evaluation of 5686 births in Bogotá.Additionally, in the results section «Single kidney associated to other pathologies was found in 46.5% cases: occult spina bifida and congenital scoliosis, three cases; anorectal malformations, 3 cases; chromosome syndromes, 2 cases; Klippel-Feil syndrome, two cases; cryptorchidie, 1 case; tricuspid insufficiency, 1 case; pre-auricular appendix in 1 case, and a case of morbid obesity. No patient with myeloid-Vater sequence or meningocele was found», which states that no patients were found with a diagnosis of Vater sequence. We would like to clarify that the term Vater sequence is currently not appropriate and it has been replaced by the term VACTERL association from the acronym vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal malformations, and limb defects4. The term association refers to «the occurrence of multiple idiopathic congenital malformations during blastogenesis»5. Given this definition, and knowing that

  13. Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract

    Science.gov (United States)

    González-Arto, Marta; Aguilar, David; Gaspar-Torrubia, Elena; Gallego, Margarita; Carvajal-Serna, Melissa; Herrera-Marcos, Luis V.; Serrano-Blesa, Edith; Hamilton, Thais Rose dos Santos; Pérez-Pé, Rosaura; Muiño-Blanco, Teresa; Cebrián-Pérez, José A.; Casao, Adriana

    2017-01-01

    Some melatonin functions in mammals are exerted through MT1 and MT2 receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens. Real-time polymerase chain reaction (qPCR) revealed higher levels of m-RNA for both receptors in the testis, ampulla, seminal vesicles, and vas deferens, than in the other organs of the reproductive tract (p < 0.05). Western blot analyses showed protein bands compatible with the MT1 in the testis and cauda epididymis, and for the MT2 in the cauda epididymis and deferent duct. Immunohistochemistry analyses revealed the presence of MT1 receptors in spermatogonias, spermatocytes, and spermatids, and MT2 receptors in the newly-formed spermatozoa in the testis, whereas both receptors were located in the epithelial cells of the ampulla, seminal vesicles, and ductus deferens. Indirect immunofluorescence showed significant differences in the immunolocation of both receptors in spermatozoa during their transit in the epididymis. In conclusion, it was demonstrated that melatonin receptors are present in the ram reproductive tract. These results open the way for new studies on the molecular mechanism of melatonin and the biological significance of its receptors. PMID:28335493

  14. Cupula-receptor cell relationships with evidence provided by SEM microdissection.

    Science.gov (United States)

    Barber, V C; Emerson, C J

    1979-01-01

    Ampullae from the inner ear of the skate, Raja ocellata, were examined by SEM to further elucidate the relationships of the sensory hairs of the receptor cells to the overlying cupula. Specimens were prepared by a variety of methods and were fractured to visualize these relationships. Critical point drying resulted in good cellular and sensory hair preservation, but the cupulae were grossly shrunken. Freeze-dried cupulae, in contrast, more closely approximated the in vivo condition. Although tissues suffered freezing damage, sensory hair bundles were readily discerned. In both critical point dried and freeze-dried ampullae, the peripheral hair cell bundles and the kinocilia of most of the central hair cells, extended across the subcupular space and contacted the cupular material. Some of the specimens were further investigated by dissection in the SEM, the process being viewed in real time stereo. Microdissection confirmed that most kinocilia were attached to the cupula. When the cupula was displaced, sensory hair bundles remained attached to it and broke preferentially at their base from the receptor cells.

  15. Duodenal organ injury severity (OIS) and outcome.

    Science.gov (United States)

    Kline, G; Lucas, C E; Ledgerwood, A M; Saxe, J M

    1994-07-01

    The effect of organ injury severity on outcome was assessed in 101 patients treated for duodenal trauma. Most patients were men (89%) and victims of penetrating wounds (93%). Grade I is minor hematoma or incomplete perforation; Grade II is major hematoma or small complete perforation; Grade III is large perforation excluding ampulla; Grade IV is large perforation at ampulla; Grade V is duodenopancreatic crunch. The injuries were as follows: Grade I (5 patients), Grade II (31), Grade III (40), Grade IV (12), and Grade V (13). Fourteen patients exsanguinated from associated vessel injury; each had Grade IV or Grade V injury. All 36 patients with Grade I and Grade II injury had primary repair; the single death was due to liver necrosis. Most (31 patients) Grade III injuries and three Grade IV injuries were treated by primary repair alone; the three deaths were unrelated to the duodenal injury. Other major injuries were treated by duodenal exclusion (4 patients), duodenal diverticulization (6), or resection (4); the single death was unrelated to the duodenum. Primary closure is favored for minor injuries and most Grade III injuries. Severe injuries may require exclusion, diverticulization, or resection.

  16. Duodenal Duplication Cyst: A Rare Differential Diagnosis in a Neonate with Bilious Vomiting

    Science.gov (United States)

    Župančić, Božidar; Gliha, Andro; Fuenzalida, Jose Varas; Višnjić, Stjepan

    2015-01-01

    Bilious vomiting is a relevant sign in neonates that requires immediate evaluation and diagnosis. A duplication of the intestinal tract is a possible cause of obstruction if located distally to the major duodenal papilla of Vater and most of them involve the jejunum, stomach, or colon. Duodenal duplications are very rare and can have an endoscopic or surgical treatment after diagnosis. We present a case of a 16-day-old term newborn that consulted because of bilious vomiting and after evaluation with imaging and upper endoscopy, a duodenal duplication cyst was found at the level of the third portion causing compression of the intestinal lumen that required surgical resolution with duodenocystostomy. PMID:26788454

  17. Väterforschung als Familienforschung Fatherhood research as family research

    Directory of Open Access Journals (Sweden)

    Walter Bien

    2004-11-01

    Full Text Available Männer im Übergang zur Vaterschaft von Ariane Schorn ist ein interessantes, empfehlenswertes Buch, das einen wichtigen, bisher wenig beleuchteten Aspekt im Alltag eines Großteils der Bevölkerung umfasst, immerhin sind bzw. werden zwischen70 und 80% aller Männer im Laufe ihres Lebens einmal Vater. Das Buch zeigt eine lebendige, nicht immer einfache Entwicklung in einer schwierigen Zeit der Familientriade.Männer im Übergang zur Vaterschaft (Men in transition to fatherhood by Ariane Schorn is an interesting and recommendable book. It is concerned with an important yet little explored aspect of the everyday life of a majority of people—after all, between 70 and 80 percent of all men become fathers at some point in their life. The book shows a lively, but not always simple process in a time that is quite difficult for the family triad.

  18. Muusikamaailm / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2011-01-01

    Muusikasõnumeid mujalt maailmast: BBC Proms - maailma suurim muusikafestival. Arvo Pärdi "Vater unser" kõlas kingitusena paavstile. Lera Auerbachi muusika on jätkuvalt menukas. Preemiaid ja tunnustusi

  19. Un modelo descriptivo del sistema reproductor hembra del coipo (Myocastor coypus II: los órganos tubulares (A descriptive model of the female reproductive system of coypu (Myocastor coypus II: tubular organs

    Directory of Open Access Journals (Sweden)

    Felipe, A. E.

    2006-03-01

    prominence. The mucous tunic of infundibulum and ampulla had many longitudinal folds with fine secondary and tertiary branches. Folds were low and undivided at the isthmus. The mucosa of the oviducts was covered by high epithelium. The double uterus consisted of two uteri with cavities quite independent from each other. A gross septum separated the cervical canals which still remained separately in the dorsal surface of the cervix. The mucous epithelium of the horns was composed of ciliated cylindrical cells that contained oval nuclei in basal position. There were abundant endometrial glands in the horns. The epithelium of the endocervix was composed of large columnar cells, with a mucus-secreting appearance. All along the uterine horns the lamina propria was composed of a lax connective tissue. The myometrium was very well-developed. The perimetrium was a serous membrane with many longitudinal muscle fibres. The vagina was a tubular organ. The fornix was divided into five cul-de-sacs. The vaginal mucosa was covered by a stratified squamous epithelium. The connective-epithelial junction was notably irregular due to the presence of many connective papillae which projected themselves from the lamina propria into the basal epithelium. The general morphology of the reproductive organs of the Myocastor coypus is typical of the hystricomorph rodents studied.

  20. Therapeutic value of endoscopic metal pyloric stent implantation for gastric outlet obstruction%经内镜放置幽门金属支架对胃出口梗阻的治疗价值

    Institute of Scientific and Technical Information of China (English)

    朱静; 张杰; 陈婧; 郎海波; 于剑锋; 郝建宇

    2012-01-01

    目的 探讨经内镜放置幽门金属支架对胃出口梗阻的治疗价值.方法 对2008年1月至2012年1月因多种良恶性疾病引起胃出口梗阻而接受内镜下幽门金属支架植入术的21例患者的病例资料进行回顾性分析.结果 21例成功进行了幽门十二指肠支架置入术,14例24小时内症状明显缓解,1例于48小时后行CRE球囊扩张后缓解,总缓解率为71.4%.21例中有3例十二指肠壶腹部受累伴梗阻性黄疸的病例成功进行了双支架的置入治疗.3例出现术中出血,对症治疗后停止.1例良性狭窄病例使用覆膜支架发生移位,4例出现支架术后再堵塞,其中2例行二次支架置入.恶性肿瘤引起的狭窄术后生存时间平均为2.5个月.结论 对由于各种原因导致胃出口梗阻且无法手术或拒绝外科治疗的患者,幽门支架的置入可有效解除梗阻,改善患者生活质量.%Objective To evaluate the therapeutic value of endoscopic implantation of metal stent in gastric outlet obstruction. Methods Data of 21 patients who developed benign or malignant gastric outlet obstruction from January 2008 to January 2011 were retrospectively reviewed. Results Endoscopic metal pyloric stents were successfully placed in 21 patients. Symptoms were subsided in 14 patients. 1 patient subsided after CRE ballon in 48 hours. Response rate was 71.4%. 3 duodenal patients ampulla involvement with cases of obstructive jaundice successfully treated two-stent implantation. Bleeding occurred in 3 patients, 1 case of benign stenosis using stent occurred displacement , Obstruction occurred in 4 patients, and 2 of them received the second metal pyloric stent. The average survival time of obstruction patient with malignant was 2.5 months. Conclusion No chance of surgical treatment or refuse surgery patients because of some causes gastric outlet obstruction can effectively remove the obstruction and improve patients quality of life.

  1. Histomorfometria e histoquímica da tuba uterina e do útero de ratas púberes e pré-púberes induzidas ao hipertireoidismo Histomorphometry and histochemistry of the uterine tubes and uterus of puberal and prepuberal rats induced for hyperthyroidism

    Directory of Open Access Journals (Sweden)

    T.S. Oliveira

    2005-08-01

    histomorphometry and histochemical analyses. The ampulla's epithelial height has risen under the thyroxine treatment in proestrus-estrus as well as in metestrus-diestrus, becoming similar to the isthmus. The hyperthyroidism increased the PAS positive and acid mucosubstances secretions of the infundibulum on the estrogenic phase coming up to the isthmus. The uterine wall in the estrogenic phase was thicker due to the thyroxine action on the endometrium and myometrium. The secretory activity and uterine collagen composition did not differ between treatments. In puberal rats, the hyperthyroidism increased the thickness of the myometrium and the uterine wall, but did not alter the uterine tubes. Hyperthyroidism on prepuberal rats induced significant changes only in the uterus. After sexual maturity, changes in the uterus and uterine tubes were observed with variable intensity and were dependent on the estrous cycle phase.

  2. A terapêutica endoscópica nas complicações biliares pós-transplante hepático Endoscopic management of biliary complications after liver transplantation

    Directory of Open Access Journals (Sweden)

    Jeany Borges e Silva Ribeiro

    2012-12-01

    cholangiopancreatography due to suspected biliary complications. RESULTS: Fifteen patients were included (10 male, mean age of 49.57 years and 36 endoscopic retrograde cholangiopancreatographies were undertaken (2.4/patient. Biliary stricture was diagnosed in 13 patients and endoscopic treatment was successful in 56% (38,46% still in treatment. Biliary leaks were found in one patient and dysfunction of the hepatobilliary ampulla with choledocholithiasis was diagnosed in one patient, both cured by endoscopic treatment. CONCLUSIONS: Post-liver transplantation biliary complications are relatively common and endoscopic treatment may result in satisfactory outcome. Stenosis was the more frequent complication in this series.

  3. Risk factors of post endoscopic retrograde cholangiopancreatography complicated pancreatitis%经内镜逆行胰胆管造影术后并发胰腺炎危险因素分析

    Institute of Scientific and Technical Information of China (English)

    黄继征; 霞明; 龚传明; 程建国; 文峰

    2011-01-01

    Objective To explore the risk factors of post endoscopic retrograde cholangiopancreatography(ERCP) complicated pancreatitis(PEP) and to provide references to its prevention. Methods Totally 1 896 patients who underwent ERCP were divided into PEP group ( n= 285) and non-PEP group ( n= 1 161 ). The risk factors of patients, operation and operator were analyzed. Results In patient factors, female, age( less than 60), pancreatitis history,without choledocholithiasis, suspected Oddi's sphincter dysfunction were the risk factors for PEP ( P < 0.05 ), but bilirubin increase, common bile duct diameter( less than 0.4cm), ampulla diverticulum, complicated diabetes or hypertension were not related with PEP( P > 0.05 ). In operation factors, pancreas imaging, pancreatic duct sphincterotomy, aerocyst dilatation of bililary sphincter muscle were related with PEP( P < 0.05 ), but the remedial or diagnostic ERCP, Oddi's sphincterometry, bile duct sphincterotomy were not related with PEP. For operators, fewer operation cases, prolonged operation time and difficult intubation were related with PEP ( P < 0.05 ), but ERCP operation defeat was not the risk factor for PEP ( P>0.05 ). Conclusion Female, aged under 60, pancreatitis history, suspected Oddi's sphincter dysfunction, poor pancreas imaging and operator's skill as well as difficult intubation were the main risk factors for PEP.%目的 探讨经内镜逆行胰胆管造影术(ERCP)后并发胰腺炎(PEP)的危险因素,为PEP的预防提供参考.方法 回顾性分析1 896例ERCP患者,分为PEP组(n=285)及无PEP组(n=1 161),对比分析两组各相关危险因素,涉及患者因素、操作因素及术者因素.结果 患者因素中女性、年龄(小于60岁)、胰腺炎病史、无胆总管结石、疑有Oddi括约肌功能障碍者易并发PEP(P0.05).操作因素中胰腺显影、胰管括约肌切开术、胆道括约肌气囊扩张术患者在PEP组所占比例明显高于无PEP组(P0.05).结论 年龄小于60

  4. Self-image and perception of mother and father in psychotic and borderline patients.

    Science.gov (United States)

    Armelius, K; Granberg

    2000-02-01

    Psychotic and borderline patients rated their self-image and their perception of their mother and father using the Structural Analysis of Social Behavior model (SASB). The borderline patients had more negative images of themselves and their parents, especially their fathers, than did the psychotic patients and the normal subjects, while the psychotic patients' ratings did not differ much from those of the normal subjects. The self-image was related to the images of both parents for borderline patients and normal subjects, while for the psychotic patients only the image of the mother was important for the self-image. In addition, the psychotic patients did not differentiate between the poles of control and autonomy in the introjected self-image. It was concluded that borderline patients are characterized by negative attachment, while psychotic patients are characterized by poor separation from the mother and poor differentiation between autonomy and control. The paper also discusses how this may influence the patients' relations to others. Psychotische und Borderline Patienten beurteilten ihr Selbstbild und ihre Wahrnehmung von Mutter und Vater mit Hilfe der strukturalen Analyse sozialen Verhaltens (SASB). Die Borderline Patienten hattten negativere Selbstbilder und Elternbilder (speziell Vaterbilder) als die psychotischen Patienten und gesunde Personen. Die Beurteilungen der psychotischen Patienten unterschieden sich dagegen nicht besonders von jenen Gesunder. Das Selbstbild stand in Beziehung zu beiden Elternbildern bei den Borderline Patienten und den Gesunden, während bei den psychotischen Patienten nur das Mutterbild für das Selbstbild bedeutsam war. Außerdem konnte bei den psychotischen Patienten nicht zwischen den Polen der Kontrolle und Autonomie bzgl. der introjizierten Selbstbilder differenziert werden. Aus den Ergebnissen wird gefolgert, dass Borderline Patienten durch eine negative Bindung charackterisiert sind, psychotische Patienten dagegen durch

  5. CBA小鼠内耳感觉上皮的参考数据%Reference data of sensory epithelium in the inner ear in CBA mice

    Institute of Scientific and Technical Information of China (English)

    刘洪; 丁大连; 孙虹; 蒋海燕; RichardSalvi

    2011-01-01

    Objective To provide useful reference data of sensory epithelium in the inner ear, the cochlear and vestibular system were carefully measured in CBA mice. Methods Six young CBA mice at three months of age were used for this study. The surface preparations of cochlear basilar membrane and vestibular end-organs were measured under light microscope. The length and the width of basilar membrane and organ of Corti were examined along the cochlear basilar membrane. In addition, the total number and the density of cochlear hair cell along the basilar membrane were also calculated. To evaluate the vestibular end-organs, the total amount of hair cells in macula of saccule and utricle were counted. The hair cell density of striola region and marginal region in saccule and utricle were calculated respectively, and the density of hair cells in cristae in membranous ampulla of three semicircular canals were also counted. Results The total length of the cochlear basilar membrane was 5.76 ±0.196 mm in CBA mice. The width of basilar membrane was 339.1 ±9.87 μm at 1.5 mm, 304.5 ± 11.82 μm at 3 mm, and 300.1 ±7.22μm at 5 mm from the cochlear base respectively. This indicated that the width of cochlear basilar membrane was gradually narrowing from base to apex. In contrast, the width of organ of Corti was 37.80±2.24 μm at 1.5 mm, 45.00±2.67μm at 3 mm, and 52.20 ± 3.16 fun at 5 mm from the base respectively, which demonstrated that the width of organ of Corti was gradually increasing from base to apex. The total number of cochlear hair cells in CBA mice was 3116.41 ± 151.91, which included 680.67 ± 17.50 inner hair cells and 2435.8 ± 143.46 outer hair cells. The density of cochlear hair cells was similar across the entire length of the cochlea with a density of 541.1 ± 9.36/mm. The density of inner hair cells and outer hair cells were 118.3±2.68/mm and 422.8 ± 11.87/mm respectively. The total number of hair cells in macula of utricle and saccule were 3300 ± 177

  6. Refractory obstructive jaundice in a child affected with thalassodrepanocytosis: a new endoscopic approach

    Directory of Open Access Journals (Sweden)

    Barresi Luca

    2010-10-01

    Full Text Available Abstract Background Liver involvement, including elevated direct-reacting bilirubin levels, is common in patients with sickle cell disease. Fifty to seventy percent of sickle cell patients have pigmented gallstones due to precipitation of unconjugated bilirubin, and cholelithiasis or choledocholithiasis are common complications. The highest prevalence of these complications occurs in patients with Gilbert's syndrome because of the combined effect of increased bilirubin production and reduced bilirubin-diphosphate-glucuronosyltransferase enzyme activity. Cholelithiasis is also a common complication in patients with thalassemia. Endoscopic removal of choledochal stones does not always resolve the clinical picture, as in cases of dysfunction of the Vater's papilla, increased bile density due to persistently impaired bile flow or distortion of the choledocus due to dilatation, or inflammation secondary to gallstone. Case presentation We report here a case of severe and persistent obstructive jaundice in a child affected with thalassodrepanocytosis and Gilbert's syndrome, previously, and unsuccessfully, treated with endoscopic removal of choledochal stones. Deep and thorough biliary washing, and stenting with a new removable polytetrafluoroethylene (PTFE-covered flared-type stent led to complete resolution of the obstructive jaundice. Conclusions This report shows that an aggressive endoscopic approach in this select category of patients can help resolve the severe complication of hemolytic anemia, thus avoiding surgery.

  7. [Hemobilia].

    Science.gov (United States)

    Galun, D; Basarić, D; Lekić, N; Raznatović, Z; Barović, S; Bulajić, P; Zuvela, M; Milićević, M

    2007-01-01

    The phenomenon now known as haemobilia was first recorded in XVII century by well known anatomist from Cambridge, Francis Glisson and his description was published in Anatomia Hepatis in 1654. Until today etiology, clinical presentation and management are clearly defined. Haemobilia is a rare clinical condition that has to be considered in differential diagnosis of upper gastrointestinal bleeding. In Western countries, the leading cause of haemobilia is hepatic trauma with bleeding from an intrahepatic branch of the hepatic artery into a biliary duct (mostly iatrogenic in origin, e.g. needle biopsy of the liver or percutaneous cholangiography). Less common causes include hepatic neoplasm; rupture of a hepatic artery aneurysm, hepatic abscess, choledocholithiasis and in the Orient, additional causes include ductal parasitism by Ascaris lumbricoides and Oriental cholangiohepatitis. Clinical presentation of heamobilia includes one symptom and two signs (Quinke triad): a. upper abdominal pain, b. upper gastrointestinal bleeding and c. jaundice. The complications of haemobilia are uncommon and include pancreatitis, cholecystitis and cholangitis. Investigation of haemobilia depends on clinical presentation. For patients with upper gastrointestinal bleeding oesophagogastroduodenoscopy is the first investigation choice. The presence of blood clot at the papilla of Vater clearly indicates the bleeding from biliary tree. Other investigations include CT and angiography. The management of haemobilia is directed at stopping bleeding and relieving biliary obstruction. Today, transarterial embolization is the golden standard in the management of heamobilia and if it fails further management is surgical.

  8. Endoscopic ultrasound-guided choledochoduodenostomy in patients with failed endoscopic retrograde cholangiopancreatography

    Institute of Scientific and Technical Information of China (English)

    Takao Itoi; Fumihide Itokawa; Atsushi Sofuni; Toshio Kurihara; Takayoshi Tsuchiya; Kentaro Ishii; Shujiro Tsuji; Nobuhito Ikeuchi; Fuminori Moriyasu

    2008-01-01

    Endoscopic ultrasonography (EUS)-guided biliary drainage was performed for treatment of patients who have obstructive jaundice in cases of failed endoscopic retrograde cholangiopancreatography (ERCP). In the present study, we introduced the feasibility and outcome of EUS-guided choledochoduodenostomy in four patients who failed in ERCP. We performed the procedure in 2 papilla of Vater, including one resectable case, and 2 cases of cancer of the head of pancreas. Using a curved linear array echoendoscope, a 19 G needle or a needle knife was punctured transduodenally into the bile duct under EUS visualization. Using a biliary catheter for dilation, or papillary balloon dilator, a 7-Fr plastic stent was inserted through the choledochoduodenostomy site into the extrahepatic bile duct. In 3 (75%) of 4 cases, an indwelling plastic stent was placed, and in one case in which the stent could not be advanced into the bile duct, a naso-biliary drainage tube was placed instead. In all cases, the obstructive jaundice rapidly improved after the procedure. Focal peritonitis and bleeding not requiring blood transfusion was seen in one case. In this case, pancreatoduodenectomy was performed and the surgical findings revealed severe adhesion around the choledochoduodenostomy site. Although further studies and development of devices are mandatory, EUS-guided choledochoduodenostomy appears to be an effective alternative to ERCP in selected cases.

  9. Microwave -assisted Synthesis Calcium Carbonate in Water/Ethylene Glycol Mixed Solvents%水/乙二醇混合溶剂中微波辅助合成碳酸钙

    Institute of Scientific and Technical Information of China (English)

    孙新园; 张群; 陈敏; 潘玉锁

    2012-01-01

    在水/乙二醇混合溶剂中,通过微波辅助加热的方法,研究溶液过饱和度对碳酸钙成核生长的影响。分别采用扫描电子显微镜(SEM)、X-射线粉末衍射(XRD)对所得的样品进行了表征。结果表明,过饱和度的改变对碳酸钙形貌和晶型具有非常明显的影响,分别获得了菱面体状方解石、纤维捆扎状文石、松树枝状球霰石为主体的碳酸钙晶体。%In this paper, the influence of diffident supersaturations of the bulk solution on the nucleation and crystal growth of calcium carbonate is studied through the method of microwave - assisted beating in water/ethylene glycol mixed solvents. The ob- tained crystals are characterized by scanning electron microscopy (SEM) and X -ray diffraction (XRD). The resuh shows that the morphologies and polymorphs are obvious varied from rhombohedron calcite, fiber strapping aragonite to pine - dendritic vater- ite with the changes of supersaturations.

  10. Familienfreundliche Betriebe nehmen auf Vaterschaft Rücksicht! Family-Friendly Businesses Show Consideration for Fatherhood!

    Directory of Open Access Journals (Sweden)

    Martin R. Textor

    2004-11-01

    Full Text Available Das Handbuch VäterArbeit zeigt auf, wie wichtig es ist, das Thema „Vatersein“ in Unternehmen und Organisationen zu diskutieren und betriebliche Maßnahmen zur Unterstützung einer kindgerechten Ausübung von Vaterschaft zu initiieren und umzusetzen. Die Politik muss dafür die entsprechenden gesetzlichen Rahmenbedingungen schaffen. Väter sollten ihre Rollen hinterfragen und die schon gegebenen Spielräume hinsichtlich einer verbesserten Vereinbarkeit von Familie und Beruf nutzen.Handbuch VaterArbeit (The CareerFather Handbook illustrates how important it is to discuss the subject of “being a father” in businesses and organizations and to initiate and apply company measures to promote a practice of fatherhood that is equitable to the child. Policy must establish the corresponding legal framework and conditions for this. Fathers should question their roles and utilize the latitude already present that promotes an improved agreement between family and job.

  11. Historisches Rätsel Als Autodidakt in die Astronomie

    Science.gov (United States)

    Loos, Andreas

    2003-05-01

    Die Sterne standen günstig für den Gesuchten: Sein Vater hatte ein Astronomiestudium abgeschlossen, wurde aber bald Direktor einer Lebensversicherung. Die Familie verfügte dadurch über ein gesichertes Einkommen - und über astronomisches Knowhow.

  12. Conflito de gerações: O expressionismo e Christoph Meckel

    Directory of Open Access Journals (Sweden)

    Claudia Dornbusch

    1997-11-01

    Full Text Available In diesem Artikel geht es darum, Charakteristika des deutschen Expressionismus und ihre Varianten in der deutschen Gegenwarsliteratur nachzuweisen. Unter dem Gesichtspunkt des Generationenkonflikts wird das 1980 veröffentlichte Werk Suchbild über meinen Vater von Christoph Meckel untersucht.

  13. The analysis on wire intervention therapy under the guidance of hysteroscope and laparoscope in the treatment of 100 patients with tubal infertility%宫腹腔镜联合导丝介入诊治输卵管性不孕症100例分析

    Institute of Scientific and Technical Information of China (English)

    武英敏

    2011-01-01

    separated and there was Methylene blue liquid outflowed from the bilateral tubal. 12 cases had one side blockage, false positive of HSG was 14.06%. 24 tubules underwent ostomy at the tubal ampulla umbrella. ②57 patients (57%) were identified with pelvic lesion, and pelvic inflammation as the predominant reason, followed by endometriosis, polycystic ovary syndrome and tuberculosis. The procedures were consisted with adhesion decomposition, endometriosis clearance and drilling of the polycystic ovary. No procedures were tried for the least promising function recovery of severe adhesion. ③Endometritis and polyps were the first and second lesions by hysteroscope. The procedures were consisted with adhesion decomposition of the endometriosis, fenestration of the oviducts and excision of polyps. No procedure was performed for the tuberculous scars. The pregnancy rates were accumulated to 41.8% in two years after operation. Conclusion: The wire intervention operation under the guidance of hysteroscope and laparoscope show a significance of diagnosis and therapy. The procedure time is shortened and more cost is saved, especially for the class I blockage. It is also important for guiding the following therapy.

  14. Peritonite meconial como diagnóstico diferencial de ascite fetal: relato de caso Meconium peritonitis in the differential diagnosis of fetal ascites: a case report

    Directory of Open Access Journals (Sweden)

    Melania Maria Ramos de Amorim

    1999-07-01

    include fetal ascites and intra-abdominal calcifications. Evidence suggests that prenatal diagnosis can improve postnatal prognosis. Case Report: R.C.M.S., 22 years, II pregnancy O para, presented ultrasound (12/02/98 with diagnosis of fetal ascites. Investigation for hydrops fetalis was performed and immune and nonimmune causes were excluded. Severe fetal ascites persisted on subsequent ultrasound examinations, without calcifications. Vaginal delivery occurred at 36 weeks (01/02/99, with polyhydramnios. Female neonate weighing 2,670 g, with signs of respiratory distress, abdominal distension and petechiae. Abdominal distension worsened progressively, with palpation of a petrous tumor in the right upper quadrant and elimination of white mucus at rectal examination. Radiological findings (01/04/99 were disseminated abdominal calcifications, intestinal dilatation and absence of gas at rectal ampulla. Exploratory laparotomy was indicated with diagnosis of meconium peritonitis. A giant meconium cyst and ileal atresia were observed and lysis of adhesions and ileostomy were performed. Initial postoperative evolution was satisfactory but was subsequently complicated by sepsis and neonatal death occurred (01/09/99. Conclusion: meconium peritonitis should be remembered at differential diagnosis of fetal ascites. In the present case, surgical indication could be anticipated if prenatal diagnosis were established, with improvement of neonatal evolution.

  15. Rare presentation of Brunner's gland adenoma:another differentiation in patients with recurrent"idiopathic" pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Soumil Vyas; James RA Skipworth; Dimitrios Lytras; Claire Smyth; Anthony Mee; Adrian Hatfield; Charles Imber; George Webster

    2012-01-01

    BACKGROUND: Brunner's  gland  adenoma  (BGA)  is  an unusual benign neoplasm arising from Brunner's glands in the duodenum. When symptomatic it presents either with duodenal obstruction  or  bleeding.  However,  pancreatitis  secondary  to ampullary obstruction from a BGA is very rare. METHODS: A  23-year-old  female  presented  with  recurrent episodes  of  "idiopathic"  pancreatitis.  She  was  extensively investigated  and  was  found  to  have  a  large  polypoid  BGA, intermittently obstructing the ampulla. This created a ball-valve  effect  causing  secondary  intermittent  obstruction  of the pancreatic duct resulting in pancreatitis. The condition was cured surgically, through transduodenal excision of the BGA. We reviewed the surgical literature pertaining to these unusual  and  similar  causes  of  obstructive  pancreatitis,  not related to gallstones. RESULTS: BGA of the duodenum is a rare cause of pancreatitis. Extensive  investigations  should  be  carried  out  in  all  cases  of unexplained  pancreatitis  before  classifying  the  condition as  "idiopathic".  Discovery  of  a  lesion  of  this  nature  gives  an opportunity to provide a permanent surgical cure. CONCLUSIONS: BGA adds an unusual etiology for pancreatitis. All  patients  with  pancreatitis  should  undergo  extensive investigations  before  being  termed  "idiopathic".  Surgical excision of the BGA provides a definitive curative treatment for the adenoma and pancreatitis.

  16. Tumor budding in upper gastrointestinal carcinomas

    Directory of Open Access Journals (Sweden)

    Viktor Hendrik Koelzer

    2014-08-01

    Full Text Available The basis of personalized medicine in oncology is the prediction of an individual’s risk of relapse and death from disease. The presence of tumor budding (TB at the tumor-host interface of gastrointestinal cancers has been recognized as a hallmark of unfavorable disease biology. TB is defined as the presence of dedifferentiated cells or small clusters of up to five cells at the tumor invasive front and can be observed in aggressive carcinomas of the esophagus, stomach, pancreas, ampulla, colon and rectum. Presence of TB reproducibly correlates with advanced tumor stage, frequent lymphovascular invasion, nodal and distant metastasis. The UICC has officially recognized TB as additional independent prognostic factor in cancers of the colon and rectum. Recent studies have also characterized TB as a promising prognostic indicator for clinical management of esophageal squamous cell carcinoma, adenocarcinoma of the gastro-esophageal junction and gastric adenocarcinoma. However, several important issues have to be addressed for application in daily diagnostic practice: 1 Validation of prognostic scoring systems for tumor budding in large, multi-center studies 2 Consensus on the optimal assessment method 3 Inter-observer reproducibility. This review provides a comprehensive analysis of TB in cancers of the upper gastrointestinal tract including critical appraisal of perspectives for further study.

  17. Pancreatic Perivascular Epithelioid Cell Tumour Presenting with Upper Gastrointestinal Bleeding

    Directory of Open Access Journals (Sweden)

    Christos Petrides

    2015-01-01

    Full Text Available PEComa is a family of rare mesenchymal tumours which can occur in any part of the human body. Primary PEComas of the pancreas are extremely rare tumours with uncertain malignant potential. A 17-year-old female was admitted to the hospital due to melena. She required several transfusions. CT scan demonstrated a mass at the head of the pancreas measuring 4.2 cm in maximum diameter. An endoscopic ultrasound showed an ulcerating malignant looking mass infiltrating 50% of the wall of the second part of the duodenum in the region of the ampulla. Multiple biopsies taken showed extensive ulceration with granulation tissue formation and underlying large macrophages without being able to establish a definite diagnosis. We proceeded with pylorus-preserving pancreaticoduodenectomy. The postoperative course of the patient was unremarkable, and she was discharged on the 8th postoperative day. Histology examination of the specimen showed a PEComa of pancreas. Eighteen months after resection the patient is disease free. To the best of our knowledge this is the first time we describe a case of a pancreatic PEComa presenting with massive gastrointestinal bleeding.

  18. Alkaline phosphatase in stallion semen: characterization and clinical applications.

    Science.gov (United States)

    Turner, R M O; McDonnell, S M

    2003-06-01

    Significant amounts of alkaline phosphatase (AP) activity have been found in semen plasma from numerous species. In species in which the majority of semen plasma AP (SPAP) activity originates from the epididymis and testicle, SPAP activity can be used clinically as a marker to differentiate testicular origin azoospermia or oligospermia from ejaculatory failure. Information on SPAP activity in stallions to date has been limited. In this study, a standard clinical chemistry analyzer was used to determine AP activity in pre-ejaculatory fluid and ejaculates from groups of normal stallions. Additionally, accessory glands, epididymides, testicles and other components of the urogenital tract of normal stallions were assayed to determine which tissues contain SPAP activity. The results indicated that levels of AP activity are low in pre-ejaculatory fluid, but significantly higher in ejaculatory fluid from normal stallions. Spermatozoa were not a significant source of SPAP activity. High levels of SPAP activity were found in the testes and epididymides. These findings suggest that SPAP activity is a candidate for a sperm-independent marker for ejaculation in the stallion. Finally, AP activity was determined in ejaculatory fluid from a stallion with bilaterally blocked ampullae, both before and after relief of the blockage. While the blockage was present, AP activity in ejaculatory fluid was low. However, following relief of the blockage, AP activity in ejaculatory fluid rose dramatically, thus suggesting that AP activity will be useful as an inexpensive, simple clinical assay for differentiating ejaculatory failure or excurrent duct blockages from testicular origin azoospermia and oligospermia.

  19. Re-identifying Grateloupia yangjiangensis (Rhodophyta, Halymeniaceae) based on morphological observations, life history and rbcL sequence analyses

    Institute of Scientific and Technical Information of China (English)

    WANG Hongwei; GUO Shaoru; ZHANG Xiaoming; ZHAO Dan; ZHANG Wen; LUAN Rixiao

    2014-01-01

    On the basis of morphological observations, life history and molecular phylogeny, Grateloupia yangjiangen-sis, which is similar to G. filicina, G. orientalis, G. catenata, and G. ramosissima in appearance, was re-exam-ined. The results are as follows:(1) the auxiliary-cell ampullae of G. yangjiangensis were of Grateloupia type, thalli was fleshy and gelatinous in texture, and the erect axes were compressed;the cortex was 0.25-0.30 mm thick, consisting of five to seven outer layers, and there were five inner layers of triangular or stellate cells;(2) there was no filamentous stage in the development of the carpospores;(3) the ribulose-1,5-bisphosphate carboxylase/oxygenase gene (rbcL) sequence of four G. yangjiangensis examined showed that there was no intergeneric divergence among them, and for the phylogenetic tree, four sequences of G. yangjiangensis formed a single monophyletic subclade within the large Grateloupia clade of Halymeniaceae. In conclusion, G. yangjiangensis was a single species within the genus Grateloupia. This research provided criterion for identification and cultivation of G. yangjiangensis.

  20. Pineapple juice as a negative oral contrast agent in magnetic resonance cholangiopancreatography: a preliminary evaluation.

    Science.gov (United States)

    Riordan, R D; Khonsari, M; Jeffries, J; Maskell, G F; Cook, P G

    2004-12-01

    The quality of magnetic resonance cholangiopancreatography (MRCP) images is frequently degraded by high signal from the gastrointestinal tract. The aim of this study is to evaluate pineapple juice (PJ) as an oral negative contrast agent in MRCP. Preliminary in vitro evaluation demonstrated that PJ shortened T(2) relaxation time and hence decreased T(2) signal intensity on a standard MRCP sequence to a similar degree to a commercially available negative contrast agent (ferumoxsil). Electrothermal atomic absorption spectrometry assay demonstrated a high manganese concentration in PJ of 2.76 mg dl(-1), which is likely to be responsible for its T(2) imaging properties. MRCP was subsequently performed in 10 healthy volunteers, before and at 15 min and 30 min following ingestion of 400 ml of PJ. Images were assessed blindly by two Consultant Radiologists using a standard grading technique based on contrast effect (degree of suppression of bowel signal), and image effect (diagnostic quality). There were statistically significant improvements in contrast and image effect between pre and post PJ images. There was particularly significant improvement in visualization of the pancreatic duct, but no significant difference between 15 min and 30 min post PJ images. Visualization of the ampulla, common bile duct, common hepatic and central intrahepatic ducts were also significantly improved at 15 min following PJ. Our results demonstrate that PJ, may be used as an alternative to commercially available negative oral contrast agent in MRCP.

  1. Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Presenting with Torsional Downbeating Nystagmus: An Apogeotropic Variant

    Directory of Open Access Journals (Sweden)

    Paolo Vannucchi

    2012-01-01

    Full Text Available The aim of this study is to verify the hypothesis that free-floating particles could sometimes localize into the distal portion of the non ampullary arm of the posterior semicircular canal (PSC so that assuming the Dix-Hallpike’s positions, the clot could move towards the ampulla eliciting a inhibitory torsional-down beating paroxysmal positional nystagmus (PPNy, instead of typical excitatory torsional-up beating PPNy. Among 45 patients with vestibular signs suggesting anterior semicircular canal paroxysmal positional vertigo (PPV, collected from February 2003 to August 2006, we detected a group of 6 subjects whose clinical findings showed a singular behaviour during follow-up. At the first check-up, all patients were submitted to different types of physical manoeuvres for ASC canalolithiasis. Patients were controlled during the same session and after one week. When we found that nystagmus was qualitatively changed we adopted the appropriate physical therapies for that sign. At a next check-up, after having performed some physical therapies, all patients had a typical PSC PPNy of the opposite side, with respect to that of the ASC initially diagnosed. Basing on these observations we conclude that PSC PPV, similarly to lateral semicircular canal PPV, could manifests in a apogeotropic variant.

  2. Reality named endoscopic ultrasound biliary drainage

    Institute of Scientific and Technical Information of China (English)

    Hugo; Gon?alo; Guedes; Roberto; Iglesias; Lopes; Joel; Fernandez; de; Oliveira; Everson; Luiz; de; Almeida; Artifon

    2015-01-01

    Endoscopic ultrasound(EUS) is used for diagnosis and evaluation of many diseases of the gastrointestinal (GI) tract. In the past, it was used to guide a cholangio-graphy, but nowadays it emerges as a powerful thera-peutic tool in biliary drainage. The aims of this review are: outline the rationale for endoscopic ultrasound-guided biliary drainage(EGBD); detail the procedural technique; evaluate the clinical outcomes and limitations of the method; and provide recommendations for the practicing clinician. In cases of failed endoscopic retro-grade cholangiopancreatography(ERCP), patients are usually referred for either percutaneous transhepatic biliary drainage(PTBD) or surgical bypass. Both these procedures have high rates of undesirable complications. EGBD is an attractive alternative to PTBD or surgery when ERCP fails. EGBD can be performed at two locations: transhepatic or extrahepatic, and the stent can be inserted in an antegrade or retrograde fashion. The drainage route can be transluminal, duodenal or trans-papillary, which, again, can be antegrade or retrograde [rendezvous(EUS-RV)]. Complications of all techniques combined include pneumoperitoneum, bleeding, bile leak/peritonitis and cholangitis. We recommend EGBD when bile duct access is not possible because of failed cannulation, altered upper GI tract anatomy, gastric outlet obstruction, a distorted ampulla or a periampullary diverticulum, as a minimally invasive alternative to surgery or radiology.

  3. Hepatic artery pseudoaneurysm caused by acute idiopathic pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Yeon Hwa Yu; Joo Hyun Sohn; Tae Yeob Kim; Jae Yoon Jeong; Dong Soo Han; Yong Cheol Jeon; Min Young Kim

    2012-01-01

    Hepatic artery pseudoaneurysm (HAP) is a very rare disease but in cases of complication,there is a very high mortality.The most common cause of HAP is iatrogenic trauma such as liver biopsy,transhepatic biliary drainage,cholecystectomy and hepatectomy.HAP may also occur with complications such as infections or inflammation associated with septic emboli.HAP has been reported rarely in patients with acute pancreatitis.As far as we are aware,there is no report of a case caused by acute idiopathic pancreatitis,particularly.We report a case of HAP caused by acute idiopathic pancreatitis which developed in a 61-year-old woman.The woman initially presented with acute pancreatitis due to unknown cause.After conservative management,her symptoms seemed to have improved.But eight days after admission,abdominal pain abruptly became worse again.Abdominal computed tomography (CT) was rechecked and it detected a new HAP that was not seen in a previous abdominal CT.Endoscopic retrograde cholangiopancreatography (ERCP) was performed because of a suspicion of hemobilia as a cause of aggravated abdominal pain.ERCP confirmed hemobilia by observing fresh blood clots at the opening of the ampulla and several filling defects in the distal common bile duct on cholangiogram.Without any particular treatment such as embolization or surgical ligation,HAP thrombosed spontaneously.Three months after discharge,abdominal CT demonstrated that HAP in the left lateral segment had disappeared.

  4. Diagnostic and therapeutic endoscopic approaches to intraductal papillary mucinous neoplasm.

    Science.gov (United States)

    Turner, Brian G; Brugge, William R

    2010-10-27

    Pancreatic cystic lesions are increasingly identified on routine imaging. One specific lesion, known as intraductal papillary mucinous neoplasm (IPMN), is a mucinous, pancreatic lesion characterized by papillary cells projecting from the pancreatic ductal epithelium. The finding of mucin extruding from the ampulla is essentially pathognomonic for diagnosing these lesions. IPMNs are of particular interest due to their malignant potential. Lesions range from benign, adenomatous growths to high-grade dysplasia and invasive cancer. These mucinous lesions therefore require immediate attention to determine the probability of malignancy and whether observation or resection is the best management choice. Unresected lesions need long-term surveillance monitoring for malignant transformation. The accurate diagnosis of these lesions is particularly challenging due to the substantial similarities in morphology of pancreatic cystic lesions and limitations in current imaging technologies. Endoscopic evaluation of these lesions provides additional imaging, molecular, and histologic data to aid in the identification of IPMN and to determine treatment course. The aim of this article is to focus on the diagnostic and therapeutic endoscopic approaches to IPMN.

  5. Grateloupia tenuis Wang et Luan sp. nov. (Halymeniaceae, Rhodophyta: A New Species from South China Sea Based on Morphological Observation and rbcL Gene Sequences Analysis

    Directory of Open Access Journals (Sweden)

    Ling Yu

    2013-01-01

    Full Text Available Grateloupia tenuis Wang et Luan sp. nov. is a new species described from Lingshui, Hainan Province, South China Sea. Based on the external form and internal structure, combined with rbcL gene sequence analysis, Grateloupia tenuis is distinct from other Grateloupia species as follows: (1 thalli is slippery and cartilaginous in texture; possess fewer branches, relatively slight main axes, and two or three dichotomous branches; (2 cortex is 5-6 layers; medulla is solid when young, but hollow in old branches; reproductive structures are dispersed in main axes of thalli and lower portions of branchlets; exhibits Grateloupia-type auxiliary cell ampullae; (3 the four studied G. tenuis sequences were positioned in a large Grateloupia clade of Halymeniaceae, which included sister group generitype G. filicina with 68 bp differences; G. tenuis was determined to be a sister taxon to the G. catenata, G. ramosissima, G. orientalis, and G. filiformis subclade. The pairwise distances between G. tenuis and these species were 39 to 50 bp. The sequences of G. tenuis differed by 81–108 bp from the sequences of other samples in Grateloupia; there are 114–133 bp changes between G. tenuis and other genera of Halymeniaceae. In final analysis, we considered Grateloupia tenuis Wang et Luan sp. nov. to be a new species of genus Grateloupia.

  6. Semiconductor gel in shark sense organs?

    Science.gov (United States)

    Fields, R Douglas; Fields, Kyle D; Fields, Melanie C

    2007-10-22

    Sharks can sense bioelectric fields of prey and other animals in seawater using an extraordinary system of sense organs (ampullae of Lorenzini) [R.D. Fields, The shark's electric sense. Sci. Am. 297 (2007) 74-81]. A recent study reported that these sense organs also enable sharks to locate prey-rich thermal fronts using a novel mode of temperature reception without ion channels. The study reported that gel extracted from the organs operates as a thermoelectric semiconductor, generating electricity when it is heated or cooled [B.R. Brown, Neurophysiology: sensing temperature without ion channels, Nature 421 (2003) 495]. Here we report biophysical studies that call into question this mechanism of sensory transduction. Our experiments indicate that the material exhibits no unusual thermoelectric or electromechanical properties, and that the thermoelectric response is an artifact caused by temperature effects on the measurement electrodes. No response is seen when non-metallic electrodes (carbon or salt bridges) are used, and ordinary seawater produces the same effect as shark organ gel when silver wire electrodes are used. These data are consistent with the voltages arising from electrochemical electrode potentials rather generated intrinsically within the sample. This new evidence, together with the anatomy of the organs and behavioral studies in the literature, best support the conclusion that the biological function of these sense organs is to detect electric fields.

  7. Constipation: A common problem in childhood

    Directory of Open Access Journals (Sweden)

    Bukarica Svetlana

    2005-01-01

    Full Text Available Introduction Constipation in children is defined as the infrequent and difficult passage of hard stool, not necessarily associated with infrequent stools. All healthy newborns have their first stool within the first 24 to 48 hours after birth. Intestinal transit time increases with age, therapy decreasing the frequency of stooling. Anatomy and Physiology of Anus and Rectum Acquisition of fecal continence requires: normal internal and external anal sphincters, puborectal muscle as well as intact sensory input from both the rectal vault and anal canal. Etiology and Differential Diagnosis During the first year of life, failure to have bowel movement every other day warrants evaluation. During infancy, constipation is usually due to dietary manipulations, malnutrition or some other functional abnormalities. Anatomic causes are found only in 5% of patients. Diagnosis and Therapy Diagnosis relies on history and physical examination. Digital rectal examination usually reveals a shorter anal canal with decreased sphincter tone. The rectal ampulla is dilated and filled with stool. Anorectal manometry is helpful in differentiating functional constipation from aganglionosis or other neurologic problems. Treatment varies depending on the underlying cause. Bowel retraining, aimed at establishing regular daily bowel movement, is of utmost importance in children. The response to treatment is usually dramatic. Conclusion Constipation in children causes anxiety in the family and successful treatment requires persistent reassurance and repeated reevaluation.

  8. The recently-described ascidian species Molgula tectiformis is a direct developer.

    Science.gov (United States)

    Tagawa, K; Jeffery, W R; Satoh, N

    1997-04-01

    Molgula tectiformis is a new ascidian species recently described by Nishikawa (1991). In Otsuchi Bay, Iwate, Japan, they are easily obtainable from cages for culturing scallops. We report here that M. tectiformis is another example of a direct developer: their embryonic development is lacking the tadpole larva. The fertilized egg is orange and about 150 microns in diameter. At 18 degrees C, the egg cleaves at about 20 min intervals and gastrulation occurs about 5 hr after fertilization. In contrast to conventionally-developing ascidians, M. tectiformis does not form a tadpole larva. Immediately before hatching, three stolons or ampullae begin to extend from the tailless embryo. After hatching the stolons mediate the attachment of the juvenile body to the substratum. Histochemistry for tissue-specific enzyme activity did not detect muscle-specific acetyl-cholinesterase, endoderm-specific alkaline phosphatase, and pigment cell-specific tyrosinase. In addition, in situ hybridization could not prove the presence of muscle actin gene transcripts in the embryo. These results suggest that these larval tissues do not differentiate in M. tectiformis embryos. Because M. tectiformis is common and gravid year-around in Otsuchi Bay, this direct developer provides the opportunity for further analysis of molecular changes during evolution that cause an alternative mode of development.

  9. 2. symposium energy crops 2009; 2. Symposium Energiepflanzen 2009

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-27

    Within the meeting '2nd Symposium energy plants 2009', held at 17th to 18th November, 2009, in Berlin (Federal Republic of Germany), the following lectures were held: (1) The bio energy policy of the Federal Government in the area of attention between climatic protection, ecology and economy (Ilse Aigner); (2) Chances and threatens of cultivation of energy plants for a sustainable energy supply (Alois Heissenhuber); (3) Certification as a prerequisite of the global exploration of bio energy (Andreas Feige); (4) A project support in the field of cultivation of energy plants, a review (Andreas Schuette); (5) Results from the investigation of the crop rotation in the EVA network (Armin Vater); (6) Optimisation of the cultivation technology of sorghum millets (Christian Roehricht); (7) The two-culture utilization system - a comparison between ecologic and conventional cultivation (Reinhold Stuelpnagel); (8) Crop rotation with energy plants - Chances and threatens for the plant protection (Baerbel Gerowitt); (9) Efficiency of utilization of water for energy plants (Siegfried Schittenhelm); (10) Utilization of arable food grasses and permanent grassland as a substrate for biogas (Matthias Benke); (11) Economical evaluation of plant fermentation substrates (Dominik Reus); (12) Energy plants as a challenge for the agricultural engineering (Heiner Bruening); (13) Influence of the design of cultivation on the subsequent effects of the cultivation of energy plants (Michael Glemnitz); (14) Energy plants and waters protection - Key aspects and possible options of action (Heike Nitsch); (15) Neophytes as energy plants - Chances and threatens (Werner Kuhn); (16) Manifold in te landscape - extensive cultivation systems with renewable raw materials as an option for nature protection? (Peer Heck); (17) Ecologic aspects of agro forestry systems (Holger Gruenewald); (18) Enhancement of the potential of energy yield of winter wheat (Wolfgang Friedt); (19) Interspersed silphie

  10. Die Konstruktion von Müttern, Vätern und Eltern

    Directory of Open Access Journals (Sweden)

    Ellinor Forster

    2004-11-01

    Full Text Available Durch die Frauen- und Geschlechterforschung wurde der Blick der Wohlfahrtsstaatsanalysen auf die unbezahlte Arbeit von Ehefrauen und Müttern sowie die wohlfahrtsstaatlichen Reformen für diese Gruppen ausgedehnt. Die vorliegende Untersuchung knüpft an die zunächst auf Mutterschaftskonzepte zentrierte Wohlfahrtsstaatsforschung an, geht jedoch darüber hinaus, indem sie den Gegenstandsbereich um die Erforschung der Vater- und Elternschaft erweitert.

  11. Buchbesprechungen und neuere Testverfahren

    OpenAIRE

    2006-01-01

    Buchbesprechungen: Siegler, R.; DeLoache, J.; Eisenberg, N. (2005): Entwicklungspsychologie im Kindes- und Jugendalter, herausgegeben von S. Pauen. Heidelberg. Dammasch, F.; Metzger, H.-G. (Hg.) (2005): Die Bedeutung des Vaters. Psychoanalytische Perspektiven. Frankfurt a. M.. Jacobs, C.; Petermann, F. (2005): Diagnostik von Rechenstörungen. Göttingen. Katz-Bernstein, N. (2005): Selektiver Mutismus bei Kindern. Erscheinungsbilder, Diagnostik, Therapie. München. Wirschi...

  12. Historisches Rätsel Der rastlose Amerikaner

    Science.gov (United States)

    Loos, Andreas

    2004-09-01

    In der Schule, die er mit acht Jahren zum ersten Mal von innen sah, hielt man ihn nicht für allzu helle - schließlich hinkte der Kleine oft hinter der Klasse her. Und es hat etwas Tragisches, wenn der wohl berühmteste Erfinder aller Zeiten und Halter von 2000 Patenten im Alter über seinen Vater sagt: Er dachte, ich sei dumm. Und ich meinte schon fast selbst, ich sei ein Dummkopf.

  13. Väterforschung als Familienforschung

    Directory of Open Access Journals (Sweden)

    Walter Bien

    2004-11-01

    Full Text Available Männer im Übergang zur Vaterschaft von Ariane Schorn ist ein interessantes, empfehlenswertes Buch, das einen wichtigen, bisher wenig beleuchteten Aspekt im Alltag eines Großteils der Bevölkerung umfasst, immerhin sind bzw. werden zwischen70 und 80% aller Männer im Laufe ihres Lebens einmal Vater. Das Buch zeigt eine lebendige, nicht immer einfache Entwicklung in einer schwierigen Zeit der Familientriade.

  14. Die Erfindung des „traditionellen Vaters“

    Directory of Open Access Journals (Sweden)

    Julia Nentwich

    2006-07-01

    Full Text Available In den meisten Diskussionen zum Thema ‚Vater‘ wird vom „traditionellen“ Vater gesprochen. Die Kritik, dass dabei nicht hinreichend geklärt wird, was damit jeweils gemeint ist und was sich hinter diesen Vorstellungen verbirgt, ist für Barbara Drinck Ausgangspunkt, verschiedene Vaterdiskurse zu analysieren. Sie untersucht in beeindruckender Detailgenauigkeit die wichtigsten Vatertheorien und Vaterbilder auf der Grundlage von pädagogischen, psychologischen und soziologischen Beiträgen der letzten 250 Jahre.

  15. Marine alien species in Greek Seas: Additions and amendments by 2010

    Directory of Open Access Journals (Sweden)

    A. ZENETOS

    2012-12-01

    Full Text Available An update of the inventory of alien marine species from the coastal and offshore waters of Greece is presented. Records were compiled based on the existing scientific and grey literature, including the HCMR database of Greek alien species (ELNAIS, technical reports, scientific congresses, academic dissertations, websites, and unpublished/personal observations. 47 species were added to the inventory, including 34 invertebrates, one vertebrate (fish, three plants, eight protozoa, and one cyanobacterium. With the new records, the inventory of alien marine species of Greece now includes a total of 237 species (33 macrophytes, 131 invertebrates, 42 vertebrates, two bacteria and 29 protozoans. Among these, the presence of the gastropodHypselodoris infucata, the bivalvesDendrostrea frons and Septifer forskaliand the chondrichthyan Rhizoprionodon acutus is reported here for the first time. Based on molecular analysis, the occurrence of Bulla arabica in Greek waters is confirmed, and the suggestion that previous records of Bulla ampulla in the Mediterranean should be considered as misidentification of B. arabica is further supported. The acclimitization status of earlier records was revised in the light of new data, and thus the fishEnchelycore anatina, Seriola fasciata andTylerius spinosissimus, the red algaeHypnea cornuta and Sarconema scinaioides, the scyphomedusaCassiopea andromeda, the cephalopodSepioteuthis lessoniana, the nudibranchChromodoris annulata and the bivalvesGastrochaena cymbium andPseudochama corbieri were upgraded from casual records to established populations. The increased rate of introductions of warm water species confirms previous findings, which link the rate of introduction in the eastern Mediterranean to climate change.

  16. [Ectopic pregnancy at the Ignace Deen University Hospital in Conakry: epidemiologic, social, demographic, therapeutic, and prognostic aspects].

    Science.gov (United States)

    Baldé, I S; Diallo, F B; Conté, I; Diallo, M H; Sylla, I; Diallo, B S; Diallo, T S; Sy, T

    2014-01-01

    The objectives of this study were to calculate the frequency of ectopic pregnancy in the department, define its epidemiological, diagnostic, therapeutic, and prognostic aspects, and determine a clear therapeutic approach appropriate to our setting. In this prospective study, we compiled all cases of ectopic pregnancy seen in 2011 and 2012 in the obstetrics-gynecology department at Ignace Deen University Hospital in Conakry. Ectopic pregnancies represented 1.3% of all deliveries over this period. In the 111 cases in this population, women aged 30-34 years accounted for 31.5%, those pregnant for the first time 40.5%, nulliparous women 35.1%, married women 72.1%, those without schooling 43.2%), and those with a history of sexually transmitted infection 57.6% (these categories are not exclusive, and the same women may be included in several). Secondary amenorrhea with abdominopelvic pain and metrorrhagia was the reason for admission in 56.5% of cases. Ultrasound in early pregnancy is infrequent in Conakry. Almost all of our patients underwent emergency surgery (80.2%) More than half of the ectopic pregnancies were located in the ampulla of the uterine tubes (73.0%). There were three abdominal pregnancies and 2 ovarian. In all cases the treatment was surgical, most often salpingectomy. Postoperative complications occurred in 35.1% of cases, most often anemia (27.9% of all cases) requiring blood transfusion in 11.7% of all cases before, during, or after surgery. The maternal death rate was 1.8%. Ectopic pregnancy remains a major concern at Ignace Deen CHU. Reduction of its frequency requires increased population awareness of sexually transmitted infections and illegal abortions. Management should be prompt and appropriate.

  17. Sulphated glycosaminoglycans (S-GAGs) and syndecans in the bovine oviduct.

    Science.gov (United States)

    Bergqvist, Ann-Sofi; Rodríguez-Martínez, Heriberto

    2006-06-01

    In vivo, bull sperm capacitation seems to occur mainly in the oviduct. Capacitation of bull spermatozoa can be triggered in vitro by exposure to heparin, a heavily sulphated glycosaminoglycan (S-GAG). We determined the concentration of S-GAGs in oviductal fluid from dairy heifers, collected over the course of several oestrous cycles via surgically implanted intraluminal catheters. We also investigated the presence of syndecans, i.e. heparan sulphate proteoglycans, in the bovine oviductal epithelium of Swedish dairy cattle during standing oestrus and the luteal phase of the oestrous cycle, using immunohistochemistry for three different polyclonal antibodies raised against human syndecan-2 and rat syndecan-1 and syndecan-2, respectively. The concentration of S-GAGs in oviductal fluid obtained from the ampullar segment of the oviduct was significantly higher (P=0.0026) than it was in fluid from the isthmic segment during the functional period, i.e. from prooestrus to metaoestrus (73.5+/-10.49 mg/L in ampullar ODF, compared to 43.2+/-10.74 mg/L in isthmic ODF); least square mean (L.S.M.)+/-standard error of the mean (S.E.M.). There was also a significantly higher concentration of S-GAGs in the fluid from the oviduct ipsilateral to the ovulation side 73.5+/-10.54 mg/L on the ovulation side, compared to 43.1+/-10.71 mg/L in the oviduct on the contralateral side (L.S.M.+/-S.E.M., P=0.0026) during this period. Both syndecan-1 and syndecan-2 were present in the epithelial cells lining all studied segments of the bovine oviduct, i.e. the UTJ, isthmus and ampulla, during both standing oestrus and dioestrus. The syndecans and S-GAGs found may influence the gametes, while they reside in the oviduct; the amounts of S-GAGs found in the bovine oviduct seem sufficient to act as capacitating factors in vivo.

  18. Electrosensitive spatial vectors in elasmobranch fishes: implications for source localization.

    Directory of Open Access Journals (Sweden)

    Ariel C Rivera-Vicente

    Full Text Available The electrosense of sharks and rays is used to detect weak dipole-like bioelectric fields of prey, mates and predators, and several models propose a use for the detection of streaming ocean currents and swimming-induced fields for geomagnetic orientation. We assessed pore distributions, canal vectors, complementarity and possible evolutionary divergent functions for ampullary clusters in two sharks, the scalloped hammerhead (Sphyrna lewini and the sandbar shark (Carcharhinus plumbeus, and the brown stingray (Dasyatis lata. Canal projections were determined from measured coordinates of each electrosensory pore and corresponding ampulla relative to the body axis. These species share three ampullary groups: the buccal (BUC, mandibular (MAN and superficial ophthalmic (SO, which is subdivided into anterior (SOa and posterior (SOp in sharks. The stingray also has a hyoid (HYO cluster. The SOp in both sharks contains the longest (most sensitive canals with main projections in the posterior-lateral quadrants of the horizontal plane. In contrast, stingray SO canals are few and short with the posterior-lateral projections subsumed by the HYO. There was strong projection coincidence by BUC and SOp canals in the posterior lateral quadrant of the hammerhead shark, and laterally among the stingray BUC and HYO. The shark SOa and stingray SO and BUC contain short canals located anterior to the mouth for detection of prey at close distance. The MAN canals of all species project in anterior or posterior directions behind the mouth and likely coordinate prey capture. Vertical elevation was greatest in the BUC of the sandbar shark, restricted by the hammerhead cephalofoil and extremely limited in the dorsoventrally flattened stingray. These results are consistent with the functional subunit hypothesis that predicts specialized ampullary functions for processing of weak dipole and geomagnetic induced fields, and provides an anatomical basis for future experiments on

  19. Helical CT defecography; La defecografia con Tomografia Computerizzata spirale

    Energy Technology Data Exchange (ETDEWEB)

    Ferrando, R.; Fiorini, G.; Beghello, A.; Cicio, G.R.; Derchi, L.E.; Consigliere, M.; Resasco, M. [Genua Univ., Genua (Italy). Ist. di Radiologia, Cattedra R; Tornago, S. [Genua Univ. Genua (Italy). 2 Clinica Ortopedica

    1999-11-01

    The purpose of this work is to investigate the possible role of Helical CT defecography in pelvic floor disorders by comparing the results of the investigations with those of conventional defecography. The series analyzed consisted of 90 patients, namely 62 women and 28 men, ranging in age 24-82 years. They were all submitted to conventional defecography, and 18 questionable cases were also studied with Helical CT defecography. The conventional examination was performed during the 4 standard phases of resting, squeezing, Valsalva and straining; it is used a remote-control unit. The parameters for Helical CT defecography were: 5 mm beam collimation, pitch 2, 120 KV, 250 m As and 18-20 degrees gantry inclination to acquire coronal images of the pelvic floor. The rectal ampulla was distended with a bolus of 300 mL nonionic iodinated contrast agent (dilution: 3g/cc). The patient wore a napkin and was seated on the table, except for those who could not hold the position and were thus examined supine. Twenty-second helical scans were performed at rest and during evacuation; multiplanar reconstructions were obtained especially on the sagittal plane for comparison with conventional defecographic images. Coronal Helical CT defecography images permitted to map the perineal floor muscles, while sagittal reconstructions provided information on the ampulla and the levator ani. To conclude, Helical CT defecography performed well in study of pelvic floor disorders and can follow conventional defecography especially in questionable cases. [Italian] Scopo di questo lavoro e' ricercare un ruolo per la defeco-TC con apparecchiatura elicoidale nello studio delle malattie del pavimento pelvico confrontandola con i risultati consolidati della defecografia tradizionale. Si sono visionati 90 pazienti, 62 femmine e 28 maschi, con eta' compresa tra 24 e 82 anni, con defecografia tradizionale; di questi, 18 casi con diagnosi dubbia sono stati studiati anche con defeco-TC spirale

  20. Vaterschaft nach der Scheidung – Die Perspektive der Väter Fatherhood After Divorce—The Fathers’ Perspective

    Directory of Open Access Journals (Sweden)

    Michael Matzner

    2004-11-01

    Full Text Available Während man in Deutschland die Situation von allein erziehenden Müttern gut erforscht hat, wandte man sich den von ihren Kindern getrennt lebenden Vätern nur äußerst selten zu. Dies ist mehr als erstaunlich, wenn man sich die in die Millionen gehende Zahl betroffener Väter und Kinder vor Augen führt. Allein im Jahr 2000 wurden 95.000 Ehepaare mit minderjährigen Kindern (146.000 geschieden. Bei Gerhard Amendts empirischer Studie handelt es sich um die erste deutschsprachige, als Buch erschienene wissenschaftliche Veröffentlichung zum Thema „Scheidungsväter“. Amendt beantwortet aus der Perspektive der Väter folgende Fragen: Wie sprechen Väter über ihre Scheidung und wie gehen sie mit den Scheidungsfolgen um? Wie verbringen sie die Zeit mit ihren Kindern? Warum brechen manche von ihnen den Kontakt zu den Kindern ab? Der neue Zugang zum Thema Scheidung bzw. Trennung über die Person des Vaters war längst überfällig und bringt neue Perspektiven und Erkenntnisse in die wissenschaftliche Debatte.While the situation of single mothers has been duly researched in Germany, very rarely has attention been given to fathers who live separated from their children. This is truly remarkable when one surveys the number, rising into the millions, of fathers and children affected. In the year 2000 alone, 95,000 married couples with dependant children (146,000 divorced. Gerhard Amendt’s empirical study can be seen as the first German-language, book length, scientific publication on “divorced fathers.” Arendt answers the following questions from the perspective of the fathers: How do fathers talk about divorce and how do they deal with the consequences of divorce? How do they spend time with their children? Why do some of them cut off contact to their children? This new access to the issues of divorce or separation with regard to the father was long overdue and brings new perspectives and realizations to the scientific debate.

  1. Das Werk des Architekten Peter Neufert.

    OpenAIRE

    Ghise-Beer, Anka

    2001-01-01

    Die folgende Arbeit thematisiert den Architekten Peter Neufert (1925-1999), Sohn des Bauhaus-Architekten Ernst Neufert (Autor der "Bauentwurfslehre", 1936). Nach dem Zweiten Weltkrieg beginnt Peter Neufert, erst noch gemeinsam mit seinem Vater, später im Alleingang, sein eigenständiges architektonisches Werk aufzubauen. 1953 wird das "Atelier Neufert" in Köln eröffnet und Neufert zählt vorwiegend ab Mitte der 50er und in den 60er Jahren zu einem der bekanntesten Architektenpersönlichkeiten Kö...

  2. Sperm capacitation in the porcine oviduct.

    Science.gov (United States)

    Tienthai, P; Johannisson, A; Rodriguez-Martinez, H

    2004-01-01

    In vitro studies suggests that sperm capacitation occurs in the sperm reservoir (SR) of the pig, with spermatozoa progressing towards the ampullary-isthmic junction (AIJ) around ovulation as a consequence of capacitation/hyperactivation. In contrast, in vivo studies are scarce. Consequently, we determined the degree of capacitation in boar spermatozoa that were retrieved from the SR of sows at well-defined periods of spontaneous standing oestrus, namely pre-, peri- and post-ovulation, using flow cytometry of Merocyanine-540/Yo-Pro-1-loaded spermatozoa. SR-spermatozoa retrieved and incubated in non-capacitating medium (bicarbonate-free mBO [mBO-]) were largely viable (70-85%) and uncapacitated (69-73%), irrespective of the stage of oestrus considered. Those undergoing capacitation were a minor proportion (1-5%) during pre- and peri-ovulation, but they significantly increased (14%) in post-ovulation oestrus. To clarify whether these SR-spermatozoa were able to undergo capacitation under stimuli, sperm aliquots were challenged in vitro either by incubation in a bicarbonate-rich medium (capacitation medium, mBO+), then further in mBO+ with 20% (v/v) of in vivo collected homologous pre-ovulatory isthmic oviductal fluid (IOF), or incubation with hyaluronan (HA, 500 microg/ml). Exposure to mBO+ significantly increased the sub-population of capacitated spermatozoa from the pre- and peri-ovulation SR, indicating that the uncapacitated SR-spermatozoa were responsive to the effector/inducer bicarbonate at levels recorded in peri-ovulatory AIJ/ampulla in vivo. While addition of IOF or HA to SR-spermatozoa incubated in capacitating medium (mBO+) maintained sperm viability without obviously inducing capacitation in pre- or peri-ovulatory SR-spermatozoa, they significantly increased these percentages during post-ovulation, when compared to baseline values of control incubations (mBO-). The results suggest that massive sperm capacitation does not occur in vivo in the porcine SR

  3. Falciform ligament abscess from left sided portal pyaemia following malignant obstructive cholangitis

    Directory of Open Access Journals (Sweden)

    Warren Leigh R

    2012-12-01

    Full Text Available Abstract Abscess formation of the falciform ligament is incredibly rare and perplexing when encountered for the first time. It is reported to occur in the setting of cholecystitis and cholangitis, but the pathophysiology is poorly understood. In this case report, we present a 73-year-old man with falciform ligament abscess following cholangitis from an obstructive ampullary carcinoma. The patient was referred to the Royal Adelaide Hospital from a country hospital, with progressive jaundice, anorexia and nausea. Prior to transfer, he deteriorated with cholangitis, dehydration and renal failure. On arrival, his abdomen was exquisitely tender along the course of the falciform ligament. His blood tests revealed an elevated white cell count of 14.9 x 103/μl, bilirubin of 291μmol/l and creatinine of 347 μmol/l. His CA 19-9 was markedly elevated at 35,000 kU/l. A non-contrast computed tomography (CT demonstrated gross biliary dilatation and a collection tracking along the path of the falciform ligament to the umbilicus. The patient was commenced on intravenous antibiotics and underwent an urgent endoscopic retrograde cholangiopancreatogram (ERCP with sphincterotomy and biliary stent drainage. Cholangiogram revealed a grossly dilated biliary tree, with abrupt transition at the ampulla, which on biopsy confirmed an obstructing ampullary carcinoma. Following ERCP, his jaundice and abdominal tenderness resolved. He was optimized over 4 weeks for an elective pancreaticoduodenectomy. At operation, we found abscess transformation of the falciform ligament. Copious amounts of pus and necrotic material was drained. Part of the round ligament was resected along the undersurface of the liver. Histology showed that there was prominent histiocytic inflammation with granular acellular eosinophilic components. The patient recovered slowly but uneventfully. A contrast CT scan undertaken 2 weeks post-operatively (approximately 7 weeks after the initial CT revealed

  4. Malignant biliary obstruction: treatment with interventional radiology

    Institute of Scientific and Technical Information of China (English)

    翟仁友; 钱晓军; 戴定可; 于平

    2003-01-01

    Objective To evaluate the method of palliative drainage by means of metallic indwelling stents or plastic tubes for patients with malignant biliary obstruction. Methods From January 1995 to Febuary 2001, 243 consecutive patients (161 men and 82 women; aged 26-91 years, mean of 61.3 years) with malignant biliary obstruction were treated with transhepatic placement of metallic stents and/or plastic tubes. Among them, 47 patients had pancreatic carcinoma, 98 cholangiocarcinoma, 28 metastatic carcinoma and 60 hepatic carcinoma. 169 stents of nine types were used in this series. After stenting, 47 patients were treated for local tumors. Procedure- and device-related complications were recorded. Patient survival and stent patency rates were calculated with Kaplan-Meier survival analysis.Results One hundred and three patients underwent successfully stent placement for the first time. Others had their stents installed 1-2 weeks after catheterization. Stents were used in 132 patients. Ninety-five patients were treated with a single stent. Seventeen patients had two stents installed for bilateral drainage,20 patients had two stents installed from top to bottom to create stenting of adequate ength, and 12 patients had stents placed across the ampulla. The 2-month mortality rate was 8.64% (21/243). Major complications occurred in two patients (0.8%, 2/243). Minor complications included self-limited bleeding into the drainage tubes and fever. The average patency of the initial stent was 7.5 months and average survival was 9 months. Thirteen patients received brachytherapy in their stents, 15 extra radiation therapy, and 19 intra-arterial infusion chemotherapy. The 47 patients treated for local tumors had an average survival of 11.3 months (log rank 32.8,P<0.001) with an average patency of 9.7 months(log rank 4.7,P<0.05).Conclusion Percutaneous transhepatic bile drainage as a palliative procedure is well tolerated by patients. After stenting, treatment for local tumor may

  5. 体外受精取卵日手淫取精失败的取精方法%Research on methods to obtain sperm after failing to obtain sperm by masturbation in oocyte retrieval for in vitro fertilization

    Institute of Scientific and Technical Information of China (English)

    蒲军; 丘彦

    2011-01-01

    目的 研究体外受精取卵日手淫取精失败的取精方法.方法 对120例体外受精取卵日手淫取精失败的临床资料进行回顾分析.结果 120例患者分别采用药物治疗法、性交法、阴茎头震荡刺激法、经直肠输精管壶腹和精囊及前列腺按摩法、经皮穿刺附睾睾丸法5种方法作为手淫取精失败的替代取精法,120例患者全部取精成功.结论 性交法、经皮穿刺附睾睾丸取精法是较满意的两种替代方法.提前冷冻精子是解决体外受精取卵日手淫取精失败的最佳方案.%Objective To research the methods to obtain sperm after failing to obtain sperm by masturbation in oocyte retrieval for in vitro fertilization. Methods To retrospectively analyse the clinical data of 120 patients failing to obtain sperm by masturbation in oocyte retrieval for in vitro fertilization. Results 120 patients adopted 5 methods respectively to obtain sperm for substitution,which including drug treatment,coitus,shaking and stimulating balanus,pressing ampulla of deferent duct and seminal vesicle and prostate per rectum, percutaneous epididymal and testicular sperm aspiration. Conclusion There are two frequently used methods to obtain sperm by coitus and percutaneous epididymal and testicular sperm aspiration for substitution. It is the optimal method to freeze sperm in advance to deal with one patient fail to obtain sperm by masturbation in oocyte retrieval for in vitro fertilization.

  6. Laryngo-tracheo-oesophageal clefts

    Directory of Open Access Journals (Sweden)

    Leboulanger Nicolas

    2011-12-01

    Full Text Available Abstract A laryngo-tracheo-esophageal cleft (LC is a congenital malformation characterized by an abnormal, posterior, sagittal communication between the larynx and the pharynx, possibly extending downward between the trachea and the esophagus. The estimated annual incidence of LC is 1/10,000 to 1/20,000 live births, accounting for 0.2% to 1.5% of congenital malformations of the larynx. These incidence rates may however be underestimated due to difficulty in diagnosing minor forms and a high mortality rate in severe forms. A slightly higher incidence has been reported in boys than in girls. No specific geographic distribution has been found. Depending on the severity of the malformation, patients may present with stridor, hoarse cry, swallowing difficulties, aspirations, cough, dyspnea and cyanosis through to early respiratory distress. Five types of laryngo-tracheo-esophageal cleft have been described based on the downward extension of the cleft, which typically correlates with the severity of symptoms: Type 0 laryngo-tracheo-esophageal cleft to Type 4 laryngo-tracheo-esophageal cleft. LC is often associated with other congenital abnormalities/anomalies (16% to 68%, mainly involving the gastro-intestinal tract, which include laryngomalacia, tracheo-bronchial dyskinesia, tracheo-bronchomalacia (mostly in types 3 and 4, and gastro-esophageal reflux disease (GERD. The syndromes most frequently associated with an LC are Opitz/BBB syndrome, Pallister Hall syndrome, VACTERL/VATER association, and CHARGE syndrome. Laryngeal clefts result from failure of fusion of the posterior cricoid lamina and abnormal development of the tracheo-esophageal septum. The causes of the embryological developmental anomalies leading to LC are not known but are thought to be multifactorial. LC appears to be mostly sporadic although some familial cases with suspected autosomal dominant transmission have been reported. The age of diagnosis depends mainly on the severity of

  7. Sobre traducciones fracasadas:

    OpenAIRE

    Dieter Messner

    2010-01-01

    V članku so obravnavani prevodi književnih besedil Petra Handkeja (Der Chinese des Schmerzes) in Christine Nöstlinger (Der geheime Großvater/el abuelo misterioso in Anatol und die Wurschtelfrau/Anatol y Desiree) iz nemščine v španščino ter Juana Marséja (El amante bilingüe) iz španščine v nemščino. Analizirani so pokrajinski in sociolektalni izrazi, ki jih avtorji uporabljajo za označevanje pokrajin in oseb. Španski prevodi avstrijskih avtorjev kažejo, da so prevajalci pri delu uporabljali zg...

  8. Franz Kafka: Raízes

    Directory of Open Access Journals (Sweden)

    George Bernard Sperber

    1997-11-01

    Full Text Available Der Text versucht den Wurzeln des Schaffens Franz Kafkas nachzugehen, und sucht diese in verschiedenen, konzentrischen und exzentrischen Kreisen. Ein erster un enger Kreis ist der der Familie Kafkas, mit der vorherrschenden Figur des autoritären Vaters. Ein zweiter und weiterer Kreis ist der des Prager Judentums, mit dem ihm auferlegten Außenseitertum, das auch den dritten und noch breiteren Kreis bedingt, und zwar den der deutschsprachigen Bevölkerung Prags am Anfang des Jahrhunderts. Die aus diesen Kreisen sprießenden Wurzeln bedingen das Außenseitertum Kafkas, befähigen ihn aber auch die Rolle des Dichters als Propheten zu übernehmen.

  9. Selected Abstracts of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-10-01

    Full Text Available Selected Abstracts of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016ABS 1. ABNORMAL FETAL GROWTH ALTERS THE METABOLIC PROFILE OF EARLY HUMAN MILK • A. Kontogeorgou, Ch. Fotakis, D.D. Briana, T. Boutsikou, A. Malamitsi-Puchner, P. ZoumpoulakisABS 2. VENTED BASE FEEDING BOTTLE IN PRETERM INFANTS WITH GERD SYMPTOMS: EFFECTS ON RESPIRATION-DEGLUTITION PATTERNS AND REFLUX • E. Cocchi, C. Zavattero, E. Maggiora, C. Peila, A. Coscia, E. Bertino, F. CresiABS 3. ANALYSIS OF CIRCULATING miRNAs IN OBESE CHILDREN BORN SMALL FOR GESTATIONAL AGE • M.F. Faienza, F. Marzano, G. D'Amato, E. Inzaghi, A. Annese, M.F. Caratozzolo, A.M. D'Erchia, M. Chiara, D. Horner, E. Sbisà, L. Cavallo, G. Pesole, S. Cianfarani, A. Del Vecchio, A. TulloABS 4. CELOSOMY: OMPHALOCELE AND GASTROSCHISIS • F. Ayari, H. Chourou, H. Mannai, M. Chour, I. Ksibi, N. Ben Ameur, M. Ben Ammara, S. KacemABS 5. BREAST MILK IN INTRAUTERINE GROWTH RESTRICTION: DIFFERENCES COMPARED TO ADEQUATE FOR GESTATIONAL AGE INFANTS • C. Fadda, A. Reali, R. Pintus, F. Deidda, A. DessìABS 6. A RATHER UNIQUE AND UNEXPECTED PEDIATRIC SURGICAL CASE • G. Gaido, E.M. Nyaga, P.E. RolandiABS 7. VATER SYNDROME • M. Tuveri, C. Porcu, G. Ottonello, L. SabaABS 8. SEVERE NECROTIZING ENTEROCOLITIS ASSOCIATED WITH GASTROSCHISIS: DIFFICULTIES OF CARE • F. Ayari, W. Barbaria, E. Marmech, I. Ksibi, M. Cheour, N. Ben Ameur, M. Ben Ammara, S. KacemABS 9. RECURRENT ABDOMINAL PAIN AND JUVENILE SOLITARY POLYP (JSP: A CASE REPORT • L. Nai Fovino, V. Rametta, F. Rigon, G. Passarella, F. Rimondi, C. Santagati, M. Berardi, F. Marino, S. Innaurato, E. Michelin, C. Lorenzetto, S. Rossin, S. RugolottoABS 10. ULTRASOUND MONITORING OF LIVER ABSCESSES IN NEWBORNS • S. de Nardi, C. Porcu, M. Puddu, M.C. Pintus, M.A. Marcialis, L. SabaABS 11. RESPIRATORY PROBLEMS IN CHILDREN WITH REPAIRED ESOPHAGEAL ATRESIA AND TRACHEOESOPHAGEAL FISTULA • F. Porcaro, L. Valfrè, L. Rotondi

  10. 双源CT在肝外胆道梗阻疾病诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    李逢春; 张祖艳; 张春宁; 刘枫

    2014-01-01

    Objective To investigate the diagnosis value of DSCT on extrahepatic biliary obstruction. Methods Summary analysis 120 cases patients' DSCT image date proved extrahepatic biliary obstruction by pathology or clinical treatment. Result There were 71 cases of bile duct stones,12 cases of cholecystitis,1 case of choledochal cyst,1 case of duodenal diverticulum nipple,1 case of biliary ascariasis,14 cases of cholangiocarcinomas,3 cases of carcinoma of ampullas,4 cases of gallbladder carcinomas,12 cases of pancreatic carcinomas. The extrahepatic bile duct expansion was seen in all cases,78 cases with expansion of bile duct of liver inside,22 cases with double duct sign. The positioning accuracy of DSCT of extrahepatic biliary obstruction was 100%,qualitative accuracy was 92.5%. Conclusion DSCT can display the location,form,size density and adjacent tissues structure accurately and clearly. It has important value of DSCT on the localization and qualitative diagnosis of biliary obstruction and the choice of clinical treatment.%目的:探讨双源CT(dual-source computed tomography,DSCT)在肝外胆道梗阻疾病诊断中的价值。方法总结分析120例病理或临床治疗证实的肝外胆道梗阻疾病患者的DSCT影像资料。结果胆管结石71例,胆管炎12例,胆总管囊肿1例,十二指肠乳头区憩室1例,胆道蛔虫1例,胆管癌14例,壶腹癌3例,胆囊癌4例,胰腺癌12例。全部病例均显示肝外胆道扩张,其中78例伴肝内胆管扩张,22例呈现“双管征”。梗阻末段胆总管内可见“靶征”或“半月征”,不规则软组织影及片状、管状影,邻近胆管壁可见增厚、毛糙等;Ⅲ期强化程度不一或无强化。在肝外胆道梗阻性疾病诊断中,DSCT定位的准确率为100%,定性符合率为92.5%。结论 DSCT显示肝外胆道梗阻性病变的位置、形态、大小、密度以及相邻组织结构准确清晰,对疾病定位、定性和临床治疗的选择具有重要价值。

  11. Estudo radiológico do megacólon em área endêmica de doença de Chagas Radiological study on megacolon cases in an endemic area for Chagas disease

    Directory of Open Access Journals (Sweden)

    Cleudson Castro

    2010-10-01

    Full Text Available INTRODUÇÃO: Foi realizado estudo radiológico do cólon em pacientes de zona endêmica da doença de Chagas usando-se a técnica do enema opaco simplificado de Ximenes e cols. MÉTODOS: Participaram 291 pacientes, com idade media de 48,8 (±12,5 anos, sendo 222 soropositivos para doença de Chagas. Fizeram radiografias na posição ântero-posterior, póstero-anterior e perfil lateral esquerdo, que foram analisadas por inspeção visual e medida do maior diâmetro em centímetros do reto e sigmoide. RESULTADOS: À inspeção visual, foi possível diagnosticar megacólon em 14 (6,3% pacientes chagásicos. A média do diâmetro da ampola retal dos chagásicos 6,3 (±1,0cm foi semelhante a dos não-chagásicos 6,2 (±1,0cm (p=0,391 e o diâmetro médio da alça sigmoide dos chagásicos 5 (±1,6cm foi maior que o dos não chagásicos 4,4 (±0,8 cm, (p=0,001. CONCLUSÕES: Excluindo-se os casos de megacólon evidente e de provável megacólon, a população chagásica continuou com o diâmetro médio do sigmoide significantemente maior (p=0,003 que a não chagásica.INTRODUCTION: A radiological study on the colon of patients from an endemic Chagas disease zone was conducted using the simplified opaque enema technique of Ximenes et al. METHODS: The study involved 291 individuals with a mean age of 48.8(±12.5 years-old, of whom 222 were seropositive for Chagas disease. Anteroposterior, posteroanterior and left lateral view radiographs were analyzed by visual inspection and measurement of the largest rectal and sigmoid diameters. RESULTS: From the visual inspection, megacolon was diagnosed in 14 (6.3% Chagas disease patients. The mean diameter of the rectal ampulla among the Chagas patients was 6.3 (±1.0cm, similar to the measurement in non-Chagas individuals: 6.2 (±1.0 cm (p= 0.391. The mean sigmoid loop diameter in the Chagas patients was 5 (±1.6cm, which was larger than among the non-Chagas individuals: 4.4 (±0.8cm (p= 0.001. CONCLUSIONS

  12. Uroboros : [aus "Uroboros"] : [luuletused] / Ene Mihkelson ; tlk. Irja Grönholm ja Gisbert Jänicke

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-

    2006-01-01

    Sisu: Uroboros : "In der Nacht fragt heimlich jemand Wie heisst du..." ; "Am Meer stand ein Mann mit einer Sense..." ; "An dem Tag als es Kugeln regnete..." ; "Zum Zeitvertrieb ersteigerte ich mir auf einer Auktion ein paar..." ; "Sie hat sich mit der Zeit eingelassen und daraus..." ; Das Feld ; "Mutter ist wieder bei mir obgleich..." ; "Wir waren ein Mädchen Wir redeten..." ; "Als ich vier Jahre alt wurde Da wurde so viel..." ; "Wer ist dein Vater Der Fremde aus der Ferne..." ; "Das letzte Wort Das letzte Das letzte Das allein...". Orig.: Uroboros : "Öö aegu keegi küsib sala Mis su nimi on..." ; "Mere ees seisis vikatiga mees..." ; "Sel päeval kui sadas kuulivihma..." ; "Ajaviiteks ostsin enampakkumisel sõpru..." ; "Ta ajaga läinud on sohki ja sellest..." ; Põld ; "Mu ema on jälle mu juures kuigi..." ; "Meid oli üks türduk Me rääkisime..." ; "Kui olin saanud neljaseks Nii väga kiitis..." ; "Kes on su isa Kaugelt tulnud võõras..." ; "Viimast sõna Viimast Viimast Ainu..."

  13. Die Verwendung von fremden Samen im Rahmen der Reproduktionsmedizin

    Directory of Open Access Journals (Sweden)

    Kentenich H

    2007-01-01

    Full Text Available Nach der "Richtlinie über künstliche Befruchtung" der Bundesärztekammer aus dem Jahr 1998 war eine Behandlung mit Spendersamen bei der Behandlung mittels In-vitro-Fertilisation (IVF und intrazytoplasmatischer Spermieninjektion (ICSI auf Antrag möglich, wenn eine Kommission bei der Landesärztekammer dem zugestimmt hatte. Da die grundlegende juristische und psychosoziale Problematik der Verwendung von Spendersamen bei der Insemination und bei der IVF/ICSI-Behandlung gleich ist, hat die Bundesärztekammer in ihren Richtlinien 2006 die Verwendung von fremdem Sperma näher geregelt. Es ergeben sich Auswirkungen für den Samenspender, das Paar und den behandelnden Arzt. Der Arzt muß sich über die rechtlichen Rahmenbedingungen informieren, der Samenspender und das Paar müssen über alle medizinischen, psychosozialen und rechtlichen Konsequenzen informiert, aufgeklärt und beraten werden. Die Identität des Samenspenders muß dokumentiert werden, damit das Kind später den genetischen Vater auf Wunsch identifizieren kann. Eine Behandlung mit Spendersamen bei der alleinstehenden Frau und dem homosexuellen weiblichen Paar scheint nach den Richtlinien der Bundesärztekammer nicht möglich.

  14. 急性胆源性胰腺炎66例诊治体会

    Institute of Scientific and Technical Information of China (English)

    赵海生

    2001-01-01

    @@我院从1997年6月至2000年6月收治急性胰腺炎98例,其中急性胆源性胰腺炎(ABP)66例,占67.3%,现就其发病原因及诊治特点,总结如下。   本组66例,男30例,女36例。年龄25~64岁,平均49岁。本组中重症胰腺炎病例均符合中华医学会胰腺外科学组1992年重症胰腺炎诊断标准。轻型ABP 46例,重型ABP 20例;有明确胆总管结石史 22例,入院后行B超、CT检查首次发现胆总管结石21例,胆囊多发结石14例,胆道蛔虫3例,胆总管囊肿1例,十二指肠乳头炎3例,Vater's壶腹部结石并狭窄2例。有不同程度巩膜黄染25例,其中重症ABP 18例,轻症ABP 7例。直接胆红素或胆碱酯酶增高26例,其中重症ABP 18例,轻症ABP 8例。血清ALT增高48例。胆总管或肝内胆管轻度扩张20例。

  15. Estudo anatomotopográfico das vias biliares extra hepáticas e do trígono cistohepático

    Directory of Open Access Journals (Sweden)

    Cavalcanti Jennecy Sales

    2002-01-01

    Full Text Available OBJETIVO: Estudar a morfologia do sistema biliar extra-hepático e do trígono cistohepático (triângulo de Calot analisando a sua disposição, variações ou malformações MÉTODOS: foram investigados 50 cadáveres adultos. RESULTADOS: em 47 casos (94% a junção hepato-cística se dava próxima ao hilo hepático. Em 3 casos (6%, a junção entre esses ductos se dava distalmente, ao nível da ampola hepato-pancreática (ampola de Vater. O ângulo formado pela junção hepato-cística foi menor que 30º em 72,3% dos casos; em 23,4% , ficou entre 30 e 45º; em 2,1% variou entre 45 e 60º e em 2,1% foi maior do que 60º. A junção hepato-cística se fez, na maior parte dos casos, pela direita (59,6%, seguida pela anterior (17%, posterior (12,8% e esquerda (10,6%. Em relação aos componentes do trígono cistohepático, a artéria cística esteve presente em 56% dos casos; a veia porta em 36%; a artéria hepática direita em 34%; a artéria hepática esquerda em 2% e a artéria hepática própria em 2% dos casos. O comprimento e o diâmetro do ducto cístico foi 2,53± 1,19cm e 0,29± 0,12cm, respectivamente. A prega espiral do ducto cístico ( válvula de Heister foi observada em 80% dos casos. O infundíbulo da vesícula biliar (bolsa de Hartmann esteve presente em 74% dos casos. Esses conhecimentos são importantes, principalmente para os cirurgiões que atuam nesta região, através de videolaparoscopia. CONCLUSÃO: No trígono cistohepático a artéria cística foi encontrada com mais freqüência.

  16. 新型动脉导管未闭封堵器治疗小儿动脉导管未闭%The new amplatzer ductal occluder for transcatheter arterial duct occlusion in children

    Institute of Scientific and Technical Information of China (English)

    汪周平; 张丽; 于明华; 黄萍; 夏树亮; 李伟; 黄晓明

    2014-01-01

    F或5F的输送鞘,可从主动脉端或肺动脉端操作释放封堵器,操作简单、方便,并发症少,封堵安全、有效.从肺动脉端释放封堵器的患儿,建议可用经胸超声心动图代替主动脉造影,可以避免穿刺主动脉,减少血管损伤.%Objective To describe early clinical experience with the new amplatzer ductal occluder Ⅱ (ADO Ⅱ) for transcatheter patent ductus arteriosus(PDA) in children.Methods Twelve children were diagnosed as PDA from Jan.2013 to Apr.2014 in Guangzhou Children and Women's Hospital.All the children who were treated with the ADO Ⅱ had the indication of a successful interventional therapy successfully.The size of device was chosen according to aortographic and transthoracic echocardiography(TTE) results and pulmonary pressure.The device was delivered in a consequent or reverse way depending on the type of PDA,the minimal diameter of PDA and the size of duct ampulla.The device was delivered in a reverse way in ten patients,and two in a consequent way before detaching the device.Another aortogram was performed in order to check the position and form of the device,the velocities of blood flow in left pulmonary artery and the descending aorta though TTE and whether there was a residual shunt.All patients were examined by TTE in 24 hours after surgery and discharged without any complications 2 days later.The patients were programmed for the cardiologic consult including an TTE and electrocardiogram in 1,3,6 and 12 months after discharge.Results Twelve patients(7 male,5 female) with a median age of(1.59 ± 1.10) years(range 0.53-4.47 years),a median weight of (9.52 ± 3.41) kg(range 5.5-18.3 kg),a median pulmonary blood flow/systemic blood flow (Qp/ Qs) of 1.64 ± 0.45 (range 1.33-2.85),a median pulmonary artery systolic pressure (32.50 ± 10.05) mmHg (range 23-58 mmHg,1 mmHg =0.133 kPa),and the minimum (2.40 ±0.68) mm (1.6-3.8 mm),underwent transcatheter ductal closure with the ADO Ⅱ.Device sizes used were

  17. Sind Bedenken hinsichtlich der Kinderwunschbehandlung lesbischer und alleinstehender Frauen berechtigt?

    Directory of Open Access Journals (Sweden)

    Brewaeys A

    2005-01-01

    Full Text Available Ob man lesbischen Paaren oder alleinstehenden Frauen ("single mothers" Zugang zu einer Kinderwunschbehandlung gibt oder nicht, ist eine weiterhin kontrovers diskutierte Frage. Oft wurde argumentiert, daß für die gesunde psychologische Entwicklung eines Kindes ein Vater vorhanden sein muß und die Kinder lesbischer bzw. alleinstehender Mütter dem Risiko späterer psychologischer Probleme ausgesetzt sind. Um potentielle Risiken dieser "alternativen" Kinderwunschbehandlung zu untersuchen, muß man sich darüber im klaren sein, daß es essentielle Unterschiede zwischen lesbischen und alleinstehenden Müttern gibt. Die Mehrzahl der lesbischen Mütter haben ihre Kinder innerhalb einer stabilen Beziehung bekommen und die Donor-Insemination war dafür ihre "erste Wahl". Ihre Kinder wachsen in einer Familie mit zwei Elternteilen auf, in der die Versorgung des Kindes meist gleichberechtigt zwischen der leiblichen und der sozialen Mutter aufgeteilt ist. Dagegen erscheint es so, daß die Mehrzahl der heterosexuellen alleinstehenden Mütter dies als "letzte Möglichkeit, Mutter zu werden" erachten und nicht länger auf einen geeigneten Partner warten wollen. Zudem bedeutet die Abwesenheit eines zweiten Elternteils in den Single-Mutter-Familien eine zusätzliche Belastung für die Mutter wie auch für das Kind. Andererseits sind die "single mothers" fast ausschließlich heterosexuell, so daß die Kinder nicht mit potentiell homophoben Reaktionen der Umwelt umgehen müssen. Beide Familien-Typen haben die Verwendung eines Samenspenders gemeinsam. In einer Follow-up-Studie zeigte sich, daß über die Hälfte aller aus lesbischen Familien stammenden Kinder im Schulalter mehr über den Samenspender wissen wollten. Es gibt insgesamt nur wenige empirische Studien, die die Konsequenzen für die herangewachsenen Kinder untersuchen. Einige Daten lediglich jüngerer Kinder von lesbischen Familien nach Donor-Insemination sind nunmehr vorhanden: Soweit beurteilbar

  18. Study of dynamics of level of physical preparedness of students.

    Directory of Open Access Journals (Sweden)

    Коvalenko Y.A.

    2010-12-01

    Full Text Available The dynamics of level of physical preparedness of students is studied in the article. A tendency is marked to the decline of level of physical preparedness of students of 1-3 courses. Methodical recommendations are presented on the improvement of the system of organization of physical education of students of the Zaporizhzhya national university. The dynamics of indexes of physical preparedness of students 1, 2, 3 courses of different years of teaching is studied. Principal reasons of decline of level of physical preparedness of students are certain. There are recommendations the department of physical education in relation to physical preparedness of students.

  19. Evolution of definition of competitiveness of products

    Directory of Open Access Journals (Sweden)

    I.A. Aleksandrov

    2010-12-01

    Full Text Available Investigational evolution of definition of competitiveness of products, certainly the stages of his development. Classification of existent approaches is improved in relation to the estimation of competitiveness of products, found out the sources of competitive edges from position of consumer cost, marginal utility, differentiation of products, demand and supply, key competense, marketing categories and ecological approach.

  20. Analysis of temperature regimes of hyperthermia of cancer of bronchi

    Science.gov (United States)

    Manak, I.; Lisenkova, A.; Nikolaeva, A.

    2006-02-01

    The model of laser hyperthermia of cancer of glandular epithelium of bronchi is offered. The conditions for achievement of destruction of cancer are determined. Simulation of processes of interaction of the continuous and pulse laser radiation with a multi-layer biotissue taking into account distribution of energy in laser radiation beam, blood stream, heat transfer, processes of absorption and dispersion are realized. Peculiar properties of hyperthermia of cancer of bronch at laser action are considered.

  1. Use of motivational levers of increase of efficiency of functioning of enterprises of region

    Directory of Open Access Journals (Sweden)

    Pakulin Sergey

    2016-02-01

    Full Text Available The method of increase of efficiency of work of labor collective is developed and approved due to the improvement of socially psychological climate. On the basis of the questionnaire questioning, utilizing separate expert descriptions of mutual relations of people in a collective, the integral index of mutual relations is measured in a collective, measures are then developed for the correction of conduct of his cocks with the purpose of improvement of morally psychological climate

  2. OF THE CONCEPT OF QUALITY OF PHYSICAL PERFECTION IN THE CONTEXT OF QUALITY OF LIFE

    Directory of Open Access Journals (Sweden)

    A. S. Khorloohiyn

    2011-01-01

    Full Text Available The urgency of definition of the concept of quality of physical perfection in a context of quality of life is described. Necessity of application to the decision of the given problem of system approaches is shown. The structure of developed model of system of quality management of granting of service as complex of the interconnected systems is defined. Questions of maintenance of a complex of means and methods of an estimation of a condition of the client and definition of a technique of formation of the correct typical program of physical preparation of the client are allocated. 

  3. Method of investigation of deformations of solids of incompressible materials

    Science.gov (United States)

    Abdrakhmanova, A. I.; Garifullin, I. R.; Sultanov, L. U.

    2016-11-01

    The aim of this work is development mathematical models, algorithm for the investigation stress-strain state of elastic solids, taking into account the incompressibility materials. The constitutive equations are received using a potential energy of deformations. The system of the linear algebraic equations is received by linearization of a resolving equation. The penalty method is applied for a modelling of the incompressibility of the material. The finite element method is used for numerical solution of the problems.

  4. Introduction of the cluster model of organisation of activity of light industry enterprises of Ukraine

    Directory of Open Access Journals (Sweden)

    Filippov Mykhaylo I.

    2013-03-01

    Full Text Available The article analyses the world experience of introduction of the cluster model of activity of enterprises. It considers main prerequisites of creation and prospects of activity of clusters in light industry in Ukraine. It justifies application of the cluster approach in Ukraine, which is a necessary condition for revival of the domestic production, increase of efficiency of innovation development of regions and achievement of a high level of economic development and competitiveness. It provides proposals on improvement of the state policy of development of innovation clusters for increase of competitiveness of economy and ensuring entry of Ukraine into the circle of economically developed countries of the world.

  5. Survey of Departments of Physiology

    Science.gov (United States)

    Ganong, William F.

    1977-01-01

    Presents data of the 1976 survey of departments of physiology. Includes comparison to 1974 and 1975 data for number of academic positions available, department budgets, graduate students and post doctoral fellows, and salaries. (SL)

  6. Review of Tolerance of Ambiguity

    Institute of Scientific and Technical Information of China (English)

    王爽爽

    2015-01-01

    In this paper, definitions of tolerance of ambiguity both at home and abroad are reviewed first. Then studies of tolerance of ambiguity and foreign language teaching both home and abroad are introduced. At last, the paper proposed that it is of great sig⁃nificance and practicality for us to make further studies on tolerance of ambiguity.

  7. FORMATION OF PARENTAL COMPETENCE OF CONDITIONS OF ELEMENTARY SCHOOL

    Directory of Open Access Journals (Sweden)

    B. V. Sergeeva

    2016-01-01

    Full Text Available Article is devoted to a problem of formation of parental competence of younger school students. Results of designing of the maintenance of parental competence of children of younger school age are presented in article. Process of formation of the parental competence of younger school students consisting of 3 blocks is also presented: target, organizational and substantial and estimated and productive, the target block assumes statement of the purpose - formation of parental competence of younger school students and consists of components: motivational and personal (manifestation of interest of parents in successful result of education of younger school students, abilities to empathy, pedagogical reflection, self-checking; Gnostic (existence at parents of knowledge of features of manifestation and formation of the pupil during the different periods of development; communicative and activity (manifestation by parents of abilities to build relationship with the pupil, to stimulate his independence in activity, to apply effective methods of education; competence-based experience (use of the approved and mastered knowledge, skills of education of younger school students in practice of family education; the organizational and substantial, including system methods and forms of formation of parental competence of younger school students; the estimated and productive block of model consists of an assessment of productivity of process of formation of the competence of parents including identification of dynamics of level of parental competence at children of younger school age assuming achievement of sufficient level of parental competence of children of younger school age, and also a condition of formation of parental competence of younger school students. Realization of model of formation of parental competence of children of younger school age of age will be effective at increase of readiness of teachers for formation of pedagogical competence of

  8. Indexes of estimation of efficiency of the use of intellectual resources of industrial enterprises

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    Audzeichyk Olga

    2015-12-01

    Full Text Available The article researches the theoretical and practical aspects of estimation of intellectual resources of industrial enterprises and proposes the method of estimation of efficiency of the use of intellectual resources.

  9. IMPROVEMENT OF DEVELOPMENT OF TOURISM OF SERBIA

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    Slobodan CEROVIC

    2007-06-01

    Full Text Available Serbia, without doubt, has qualitative and diverse base to develop tourism. Natural attractions as well as attained level of lodging and other capacities point out that numerous types of tourism could be developed, especially if one takes into account landscape diversity as well as natural potentials of Serbia. Previous development of tourism affirms its numerous effects which, in significant manner, have been embedded in economic and social development of Serbia. In that connection, the aim of this work is to point out the necessity of stimulating tourism in Serbia, which would form necessary assumptions for its dynamic role in the development of Serbia’s economy.

  10. Impact of

    OpenAIRE

    K. Velmurugan; A.P. Sathiyagnanam

    2016-01-01

    The uses of biodiesel in diesel engines result in reduction of exhaust emissions, though many researchers described that the biodiesel produces higher NOx emissions than diesel, which is detract from the inflation of the market for these fuels. The aim of the present study was to analyze the experimental exploration of the three antioxidants DEA (Di-Ethyl Amine), PHC (Pyridoxine Hydro Chloride) and TBHQ (Tert Butyl Hydro Quinone) on engine emission and performance of a single cylinder diesel ...

  11. Computation of Modulus of Elasticity of Concrete

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    Onwuka, D.O

    2013-09-01

    Full Text Available - In this presentation, a computer based method which uses a set of algebraic equations and statistical data, were used to compute concrete mixes for prescribeable elastic concrete modulus, and vice versa. The computer programs based on Simplex and Regression theories can be used to predict several mix proportions for obtaining a desired modulus of elasticity of concrete made from crushed granite rock and other materials. The modulus of elasticity of concrete predicted by these programs agreed with experimentally obtained values. The programs are easy and inexpensive to use, and give instant and accurate results. For example, if the modulus of elasticity is specified as input, the computer instantly prints out all possible concrete mix ratios that can yield concrete having the specified elastic modulus. When the concrete mix ratio is specified as input, the computer quickly prints out the elastic modulus of the concrete obtainable from a given concrete mix ratio.

  12. OF INERTIAL PROPERTIES OF SOILS

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    Sargsjan Akop Egishovich

    2012-10-01

    The article describes the motion of the construction foundation slab as a rigid body with six degrees of freedom on the surface of the inertial linearly deformable semi-space. The dynamic mechanical model of the base is presented as six pairs of parallel-connected springs and dampers that characterize the rigidity of the base subjected to ultimate forces (three forces alongside the axes and three moments in relation to the axes.

  13. WORKING OUT OF A METHODS OF CONSTRUCTION OF A RATING OF LIQUIDITY OF FUNCTIONING OF COMMERCIAL BANKS OF UZBEKISTAN

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    Altinbek Ya. Abdullaev

    2015-01-01

    Full Text Available Article is devoted to a technique of construction of a rating of liquidity of functioning of commercial banks. In article are analyzed probability of event which consists that commercial bank during a certain interval of time will be liquid to function taking into account influence of random factors, i.e. regularly and in due time to carry out all functions. The special attention is given to questions of a problem of working out and introduction of a method of a rating of liquidity of commercial banks in Uzbekistan. By working out and research of the given problem methods and receptions of probability theory, the mathematical statistics and econometric modeling are used. The author comes to conclusion, that in article the technique of forecasting of a financial condition of commercial bank according to which liquidity of commercial bank is defined by probability of the event, consisting is proved what to be during a certain interval of time in the near future will be liquid to function taking into account influence of casual parameters. By imitation of parameters of the equations there is a possibility of monitoring, the control and the forecast of a rating of liquidity of commercial bank in the near future. By results of research are prepared corresponding prognosis recommendations and offers for the persons making of the decision.

  14. History of chemotherapy of leprosy.

    Science.gov (United States)

    Noordeen, Shaik K

    2016-01-01

    Chemotherapy of leprosy over the past 70 years has passed through several phases, from sulfones, to clofazimine, and to highly bactericidal drugs like rifampicin. The use particularly of the more potent drugs in effective combinations and the development of standard multidrug therapy regimens have made a huge difference in the successful treatment of leprosy as well as in reducing tremendously the prevalence of leprosy globally. A major contributing factor to development of better drugs and drug combinations has been the introduction of the mouse footpad model to evaluate the in vivo activity of drugs against Mycobacterium leprae. The World Health Organization has recommended multidrug therapy, which has been used to treat more than 15 million patients in the last 30 years and has set an excellent record with regard to its very high rate of cure, very low occurrence of relapse, and very rare occurrence of drug resistance.

  15. RELIABILITY OF TRANSPORTATION SYSTEMS OF ROCK HAPS

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    A. Stepanov

    2009-01-01

    Full Text Available The ways of increasing of exploitation reliability of dump trucks with the aim of increasing of effectiveness of exploitation of transportation systems of rock heaps at coal mines.

  16. Problem of mathematical deduction of the existence of black holes

    Directory of Open Access Journals (Sweden)

    Yuan-Shun Chin

    1990-01-01

    Full Text Available The mathematical proof of existence of Black Hole is based on the assumption of mass being independent of speed. Considering the effect of special relativity of the dependence of mass with speed there is no Black hole.

  17. Conservation of wetlands of Tanzania

    OpenAIRE

    Bakobi, B.L.M.

    1993-01-01

    The major wetland systems of Tanzania are described together with specific functions,products and attributes of lakes, rivers, swamps, estuaries, mangroves and coastal areas. Reasons and priorities for the conservation of wetlands are given together with the existingproblems of wetland conservation and their solutions.

  18. Discriminant of system of equations

    CERN Document Server

    Esterov, Alexander

    2011-01-01

    What polynomial in the coefficients of a system of algebraic equations should be called its discriminant? We prove a package of facts that provide a possible answer. Let us call a system typical, if the homeomorphic type of its set of solutions does not change as we perturb its (non-zero) coefficients. The set of all atypical systems turns out to be a hypersurface in the space of all systems of k equations in n variables, whose monomials are contained in k given finite sets. The hypersurface B contains all systems that have a singular solution, this stratum is conventionally called the discriminant, and the codimension of its components has not been fully understood yet (e.g. dual defect polytopes are not classified), so the purity of dimension of B looks somewhat surprising. We deduce it from a certain tropical purity fact of independent interest. A generic system of equations in a component B_i of the hypersurface B differs from a typical system by the Euler characteristic of its set of solutions. Regarding...

  19. Comparative analysis of indexes of physical preparedness of footballers of professional commands of different level

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    Shalenko V.V.

    2010-01-01

    Full Text Available This paper deals with results of the research of physical preparedness of professional teams of footballers of different level. The pedagogical testing program of the physical skills level includes control exercised recommended by the scientific-methodical committee of Ukrainian Federation of Football. The article presents indices of physical preparedness of footballers of different playing roles of the top league teams of Ukrainian championship and first league of Ukrainian team championship. Differences of physical preparedness structure of goalkeepers, defenders, halfbacks and forwards are revealed.

  20. Fundamentals of equations of state

    CERN Document Server

    Eliezer, Shalom; Hora, Heinrich

    2002-01-01

    The equation of state was originally developed for ideal gases, and proved central to the development of early molecular and atomic physics. Increasingly sophisticated equations of state have been developed to take into account molecular interactions, quantization, relativistic effects, etc. Extreme conditions of matter are encountered both in nature and in the laboratory, for example in the centres of stars, in relativistic collisions of heavy nuclei, in inertial confinement fusion (where a temperature of 10 9 K and a pressure exceeding a billion atmospheres can be achieved). A sound knowledg

  1. Perfection of physical preparation of students by facilities of boxing

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    Krylovskiy O.V.

    2010-02-01

    Full Text Available The question of physical preparedness of students of the unspecialized institutes of higher of I-IV of courses is considered. Offered and grounded idea of the use of facilities of boxing in form educational trainings employments. They are used for perfection of physical preparation of students as an alternative to the lessons on physical education. For the students of experimental group more considerable increase of indexes of physical preparedness is marked by comparison to a control group.

  2. Summary of Code of Ethics.

    Science.gov (United States)

    Eklund, Kerri

    2016-01-01

    The Guide to the Code of Ethics for Nurses is an excellent guideline for all nurses regardless of their area of practice. I greatly enjoyed reading the revisions in place within the 2015 edition and refreshing my nursing conscience. I plan to always keep my Guide to the Code of Ethics for Nurses near in order to keep my moral compass from veering off the path of quality care.

  3. Measurement of Spin of Projectiles

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    S. R. Verma

    1989-01-01

    Full Text Available Hitherto the spin of the projectile has been measured with the help of spin loop method (for magnetised projectiles and Multishot Ballistic Synchro method (for magnetised and non-magnetised projectiles. This paper discusses the method of measurement of spinwith a single ballistic synchro picture; the advantage of this method is that it dispenses with elaborate and precise optical alignment, required for Multishot Ballistic Synchro method.

  4. Ways of improvement of financial provision of industrial development

    Directory of Open Access Journals (Sweden)

    Shemyakina Natalya V.

    2013-03-01

    Full Text Available The article conducts the study of the state of financial provision of industrial development under modern conditions and justifies main ways of improvement and prospects of investment financing of technical development of the production potential. Classical theses and fundamental works of foreign and domestic scientists, statistical indicators and results of author’s studies of the problems of financing of technical development of industry became the methodological basis of the study. Using the conducted analysis of the state of financing the industrial development in Ukraine, potential sources of financial resources of development of the production potential (profit, depreciation, means of financial institutions and leasing, condition of the state financial support of technical development of the industrial sector and taking into account the modern experience of foreign countries, the article justifies main ways of improvement of the financial provision of industrial development. The proposed ways of improvement of financial provision of industrial development are based on: orientation at the modern model with attraction of all potential investment sources; state-private co-financing of investment projects of production development; de-centralisation of the state support through the use of various channels of support of the processes of industrial development; and formation of the market infrastructure of ensuring of financing of the innovation and investment process in industry.

  5. Direction of use of instruments of classic concept of municipal marketing in development of competitiveness of a city

    Directory of Open Access Journals (Sweden)

    I.M. Budnikevich

    2011-10-01

    Full Text Available The prerequisites of formation of the concept of classical marketing in Ukraine are considered in the paper. The definition of the municipal marketing in the framework of the classical concept is offered. The role of marketing instruments in formation of competitive advantages of the city is determined. The variants of segmentation of city environment and strategies of municipal marketing towards target markets are described. The experience of Dresden (Germany in the field of realization of marketing concept is studied.

  6. The environment of marketing of football clubs of Iraq

    Directory of Open Access Journals (Sweden)

    Michuda Y.P.

    2012-01-01

    Full Text Available Features and conditions of use of marketing in professional football of Iraq are presented, characteristic features of macroenvironment and a microenvironment in which marketing activity of professional football clubs of Iraq is carried out are considered. In research the data of questionnaire 76 experts of Association of football of Iraq (IFA, and also 45 heads of football clubs of the Superleague of Iraq is used. The maintenance and role of environment in formation and functioning of a control system by marketing activity of football clubs of Iraq is defined. Positive and negative factors which define management efficiency marketing of football clubs are revealed.

  7. RELIABILITY OF BRAKE SYSTEMS OF BUSES OF GROUP MAZ

    OpenAIRE

    A. Bessarab

    2013-01-01

    All over the world safety of maintained vehicles has the major value. For motor vehicles of the Republic of Belarus this problem is also actual. Maintenance of high reliability of brake systems of cars in operation is one of ways of the decision of a problem of increase of traffic safety.The analysis of reliability of brake systems of buses MAZ is carried out following the results of the state maintenance service in 2010 and the analysis of premature returns from routes of movement of buses M...

  8. Evaluation of perception of quality of life of disabled athletes

    Directory of Open Access Journals (Sweden)

    Bolach Bartosz

    2014-01-01

    Full Text Available Purpose: To evaluate the perception of quality of life for athletes - disabled, participating in individual and team Paralympic sports. Material: The study involved 32 athletes sports club "Start" in Wroclaw in 2013, engaged in individual sports: swimming, weightlifting, powerlifting (powerlifting and command: wheelchair basketball and volleyball in a sitting position. Results: Studies have proven that sports people with physical disabilities have a positive effect on the quality of their lives. Conclusions: 1. Study aspects of perception of quality of life is a complex issue, but deserves proper attention and appropriate force to study it. 2. Athletes - Disabled involved both individual and team sports, the perception of quality of life is average.

  9. Impact of

    Directory of Open Access Journals (Sweden)

    K. Velmurugan

    2016-03-01

    Full Text Available The uses of biodiesel in diesel engines result in reduction of exhaust emissions, though many researchers described that the biodiesel produces higher NOx emissions than diesel, which is detract from the inflation of the market for these fuels. The aim of the present study was to analyze the experimental exploration of the three antioxidants DEA (Di-Ethyl Amine, PHC (Pyridoxine Hydro Chloride and TBHQ (Tert Butyl Hydro Quinone on engine emission and performance of a single cylinder diesel engine fueled with methyl ester of mango seed. The experiment is conducted with different antioxidant concentrations of mango seed methyl ester mixtures (100, 250, 500 and 1000 ppm.The results exhibited that PHC is effectual in controlling NOx emissions than TBHQ and DEA.

  10. [Modes of action of IUDs].

    Science.gov (United States)

    Janaud, A

    1982-05-01

    There are between 14-17 million women in the world, excluding China, who wear an IUD, or about 3-5% of all married women younger than 45. Studies on the mode of action of IUDs have been conducted mostly on laboratory animals; they show that ovulation and fecundation are not inhibited by the presence of an IUD. Contrary to what was generally believed, the latest studies have shown that the principle mode of action of the IUD is not its anti-implantation effect, but it depends on the adjustment inside the uterine cavity between the size of the uterine cavity itself, and the size and shape of the device. Endometrial modifications caused by IUDs include inflammatory phenomena, and inhibition of endometrial maturation. Moreover, copper IUDs act directly on spermatozoa and on endometrial steroid receptors. It is still not clear what role prostaglandins play in the mechanism of action of IUDs. Incidence of ectopic pregnancy is not greater in IUD wearers than in women who do not use contraception. Follicle stimulating hormone and luteinizing hormone levels also are comparable in IUD wearers and in nonwearers. IUD wearers have a shorter luteal phase, which entails an earlier menstrual bleeding due to the antifibrinolytic action of the IUD; progesterone levels are identical in users and in nonusers of IUDs.

  11. Hypertrophy of Ligament of Treitz

    Directory of Open Access Journals (Sweden)

    Siddharth P. Dubhashi

    2015-04-01

    Full Text Available Congenital duodenal obstruction commonly occurs due to malrotation, atresia, stenosis and annular pancreas in decreasing order of frequency. This is a case report of a 12 year old male child who presented with complaints of non-projectile vomiting and abdominal distension and pain after meals since 7 years. Barium study showed narrowing of the Duodeno-jejunal(DJ junction due to hypertrophied ligament of Treitz. Exploratory laparotomy revealed a dilated stomach and collapsed bowel loops. There were adhesions at DJ junction and other parts of the small intestine. Adhesiolysis was done. The followup revealed a weight gain of 2 kg. The barium study was repeated which also revealed a normal study. Congenital obstruction of duodeno-jejunal junction due to extrinsic band or due to narrower attachment of ligament of Treitz at duodeno-jejunal flexure is a rare cause of bilious vomiting in the newborn period. A broad attachment of the ligament of Treitz makes a smooth obtuse angle at the duodeno-jejunum junction whereas a narrower insertion creates an acute angle that predisposes to obstruction.Duodenal obstruction may rarely occur in the presence of a normally rotated gut.

  12. The Characterization of the Spectrum of a Class of Relations

    Directory of Open Access Journals (Sweden)

    The Characterization of the Spectrum of a Class of Relations

    2007-06-01

    Full Text Available Hereditary, directed subsets of a group and a semigroup and some of their properties are discussed. A class of relations in terms of the range projections of a partial representation of a discrete group is introduced. It is shown that the spectrum of these relations is homeomorphic to the set of all characters of the diagonal subalgebra of the Toeplitz algebra.

  13. Types of Meaningfulness of Life and Values of Future Teachers

    Science.gov (United States)

    Salikhova, Nailia R.

    2016-01-01

    The leading role of meaning of life in regulation of human's activity of all types provides the relevance of the research. The goal of the paper is to identify and describe types of meaningfulness of life in future teachers, and to reveal the specificity of values hierarchy indicative of each type. The leading approach applied in the research was…

  14. Analysis of sedimentation of canals

    Directory of Open Access Journals (Sweden)

    Agunwamba, J.C.,

    2013-03-01

    Full Text Available The dredged canals in the Niger Delta coastal flood plain are being threatened by siltation. This study is limited to those canals in Rivers State of Nigeria, which are under the influence of tidal waves. A total of eight canals were considered with four each from Ekulama and Cawthorne Channel. Different approaches were used to carry out this study, which includes field reconnaissance survey, hydrographic survey, soil sample analysis and collection of all available data and information. The typical bed materials size (D50 is approximately 0.01mm; which gives a settling velocity of 0.09mm/sec using stroke’s law. Hydrographic survey of the canals from 1992 to 1996 revealed an average siltation rate of 2.35m/yr. A regression equation was also derived which relates the cost of dredging to canal area, rate of siltation and average aggregation. A plot of canal centre profile; entrance, middle and end cross sections showing sediment distribution along the canal profile, shows that majority of the particles that form the sediment enter the canal from the rivers. The sedimentation is caused by the reduction in water current, which has average value of 0.0145m/sec. The bathyorographical check on the canals revealed that the sum of the two exterior angles of the canal with the river at the point of connection has to lie within 1800 + 50 for an effective flow that will minimize settlement of particles. In addition, the canals should be constructed to start and terminate on a moving water body, to avoid dead ends. A regression equation was determined which relates the cost of dredging to canal area, rate of siltation and average aggradations.

  15. IMPLEMENTATION OF INNOVATIVE PROSPECTS OF THE LABOR MARKET OF UKRAINE

    OpenAIRE

    V. Chuvardynskyi

    2015-01-01

    The foreign experience of the provision of innovative development of labour market was investigated. The current tendencies of the development of labour market segments were analyzed. The main problems of the providing of the possibilities of innovative prospects of labour market development realization were defined. The most important reason is the saving of the significant share of low-effective labour in the occupational and qualification structure of labour force. The ways of the realizat...

  16. Analysis of Risks and Factors of Formation of the Structure of Financial Capital of Subject of Entrepreneurship

    Directory of Open Access Journals (Sweden)

    Rubaha Mariya V.

    2013-11-01

    Full Text Available The article is devoted to analysis of the structure of sources of financing economic subjects, study of commercial and financial risks of formation of the structure of financial capital of subjects of entrepreneurship. The article pays significant attention to calculation of the weighted average cost of capital, degrees of financial and operational leverages and also to assessment of their mutual influence upon results of financial and economic activity of an enterprise. It studies impact of factors of external environment on the structure of sources of financing subjects of entrepreneurship, these factors include specific features of operational activity, quality and liquidity of assets, concentration of own capital, stages of the life cycle, level of profitability of operational activity, credit history of a borrower and a necessity to ensure the prospective repayment capacity, and financial mentality of owners and managers of an enterprise. The article also analyses factors of external environment of an enterprise (cost of attraction of financing from different sources, commodity and financial markets situations, state regulation and control over business processes, level of taxation of profit of enterprises and also income of physical persons and legal entities – investors from owning securities that influence the possibilities to attract financial capital and, consequently, prospects of efficient functioning of a subject of entrepreneurship in a long-term prospect.

  17. Effects of

    Directory of Open Access Journals (Sweden)

    S. Gowthaman

    2016-03-01

    Full Text Available This work investigates the effect of both inlet air temperature and fuel injection pressure on performance and emission behaviour of homogeneous charge compression ignition engine (HCCI fuelled with diesel fuel. In this investigation, HCCI engine operates with different inlet air temperature and fuel injection pressure, and analysis the effect of these variables on HCCI engine performance and emissions. The inlet air temperatures are varied between 40 °C and 70 °C and the injection pressure in the port fuel injector is varied from 3 bar to 5 bar respectively. From the results, the optimum inlet air temperature and fuel injection pressure for efficient HCCI engine operation are identified. The result shows that, brake thermal efficiency of HCCI is nearer to the value of conventional diesel engine, and can be obtained if HCCI engine operates with 5 bar injection pressure and 60 °C air temperature and a simultaneous reduction in oxides of nitrogen (NOx and smoke emissions compared to conventional diesel engine. However, when inlet air is heated for improvement of vaporisation of diesel fuel, the higher inlet air temperature limits the operation range of HCCI engine, due to high knocking intensity, high NOx emissions and misfire of charge. The fuel injection pressure is also limited due to high level of HC and NOx emissions.

  18. RELIABILITY OF BRAKE SYSTEMS OF BUSES OF GROUP MAZ

    Directory of Open Access Journals (Sweden)

    A. Bessarab

    2013-01-01

    Full Text Available All over the world safety of maintained vehicles has the major value. For motor vehicles of the Republic of Belarus this problem is also actual. Maintenance of high reliability of brake systems of cars in operation is one of ways of the decision of a problem of increase of traffic safety.The analysis of reliability of brake systems of buses MAZ is carried out following the results of the state maintenance service in 2010 and the analysis of premature returns from routes of movement of buses MAZ-103 and МАZ-104 one of the motor transportation enterprises of a city of Minsk. Principal causes of structural parameters modification of brake pneumatic system of buses, the brake mechanism and elements АBS are considered.

  19. ABOUT FORMS OF REALIZATION OF THE FUNCTIONS OF THE STATE

    Directory of Open Access Journals (Sweden)

    Novikova A. S.

    2015-11-01

    Full Text Available The article is devoted to consideration of questions of functions of the state and forms of their realization, which are of very great importance in the theory of the state and practice of its functioning. It can be explained with the next moments, first, to that in functions are shown essence of the state, its social appointment. The state representing the phenomenon of social life, it is characterized by extraordinary variety of directly observable and perceived manifestations. It is defined as a variety of the tasks solved by the state in various areas of life of society, and a variety of bodies, forms, methods and means of implementation of the state activity. In this regard studying of functions serves as the prerequisite of knowledge of the main thing and defining in the state. Secondly, functions of the state define its structure, i.e. ways, regularities of the organization of elements of the state as difficult system. Research of functions of the state and forms of their realization helps to estimate its opportunities, promotes deeper understanding of the mechanism of its interaction with other structures of society in the solution of the most important political, economic, social, ecological, cultural and other tasks. The correct establishment of functions of the state and definition of forms of realization of these functions promotes stabilization of the public relations and development of society in various spheres

  20. Mode of Action of Glyphosate

    Science.gov (United States)

    Although glyphosate is the most used and studied herbicide in the world, the available information is not enough to fully understand its mode of action. The molecular site of action of glyphosate is the enzyme 5-enolpyruvlyshikimate-3-phosphate synthase (EPSPS). It is the only known compound that ...

  1. Genetics of onset of asthma

    NARCIS (Netherlands)

    Dijk, F. Nicole; de Jongste, Johan C.; Postma, Dirkje S.; Koppelman, Gerard H.

    2013-01-01

    Purpose of review Most asthma starts early in life. Defining phenotypes of asthma at this age is difficult as many preschool children have asthma-like respiratory symptoms. This review discusses progress in defining early wheezing phenotypes and describes genetic factors associated with the age of o

  2. Aspects of productivity of mangroves

    Digital Repository Service at National Institute of Oceanography (India)

    Wafar, S.

    ) and this sorts into two distinct geographical assemblages (1) Indo-Pacific region, comprising of South-east Pacific archipelago as far East as Samoa and (2) West Africa - American region comprising of Atlantic coast of tropical America and the Galapagos Islands...

  3. Birds of Prey of Wisconsin.

    Science.gov (United States)

    Hamerstrom, Frances

    This copiously illustrated document is designed to be a field quide to birds of prey that are common to Wisconsin, as well as to some that enter the state occasionally. An introduction discusses birds of prey with regard to migration patterns, the relationship between common names and the attitudes of people toward certain birds, and natural signs…

  4. PECULIARITIES OF CONSTRUCTION PROFILES OF SECURITY SYSTEMS OF INFORMATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    Olga V. Lukinova

    2015-01-01

    Full Text Available Examines the specific issues of building functional and technological profiles of the security systems to ensure the safety of information systems in the paradigm of functional standardization; shows a view of the system of protection based on the model of OSE/RM; studied the composition and structure of the concept of "defense mechanism" for the purpose of profiling third instalment correction representation of the system of protection.

  5. INFLUENCE OF PARAMETERS OF CRYSTALLIZATION ON MODIFYING OF AN ALLOY

    Directory of Open Access Journals (Sweden)

    V. Yu. Stetsenko

    2015-01-01

    Full Text Available It is shown that extent of modifying of an alloy is proportional to overcooling at its hardening, viscosity of fusion and interphase superficial energy of crystals of the leading phase. The key technological parameters of modifying of an alloy are the speed of its hardening, viscosity of fusion and extent of refinement from surface-active elements. Their adsorption on crystals of the leading phase interferes with modifying of an alloy.

  6. Analysis of the automated systems of planning of spatial constructions

    Directory of Open Access Journals (Sweden)

    М.С. Барабаш

    2004-04-01

    Full Text Available  The article is devoted to the questions of analysis of existing SAPR and questions of development of new information technologies of planning on the basis of integration of programmatic complexes with the use of united informatively-logical model of object.

  7. Logic of management of strategic problems of the enterprise

    Directory of Open Access Journals (Sweden)

    Ivahnenko Aleksandr Vladimirovich

    2014-12-01

    Full Text Available Problems of management by firm in the conditions of changes are considered, types of strategic problems, logic of constructions of system of strategic management are allocated. Principles of formation of strategy of firm and a strategy choice in conditions not full definiteness are defined.

  8. FEATURES OF DEFINITION OF TAX BURDEN OF AN ECONOMIC ENTITY

    Directory of Open Access Journals (Sweden)

    Sobchenko N. V.

    2015-12-01

    Full Text Available The results of an analytical assessment of the developed frame of reference on concepts of tax planning, tax burden, tax burden of the enterprise are presented in article. Tax planning is the most important part of financial planning of the organization. A basis of this process is possibility of each taxpayer to use legislatively resolved means, receptions and ways directed on minimization of tax payments. Minimization of taxes is directed not only on absolute decrease in volumes of tax payments, but also on purposeful transfer of business to more favorable conditions of managing. Tax planning is connected with recognition of the right of each taxpayer to apply all legislatively resolved means, receptions and ways to decrease in tax payments. The analysis of a condition of tax burden of an economic entity of real sector of economy is carried out. It is noted, that by means of various techniques of its assessment it is possible to receive contradictory data on dynamics of change of level of tax burden. As one of factors of increasing the efficiency of business activity is optimization of tax payments and implementation of tax planning acts. Importance of realization of tax planning and optimization of tax payments is defined by desire of taxpayers to lower tax burden and explainable aspiration of the state to prevent it

  9. Problems of formation of the financial resources of small businesses

    Directory of Open Access Journals (Sweden)

    Gorbunova Irina Ivanovna

    2014-05-01

    Full Text Available Article is devoted problems of formation of financial resources of small enterprises. In article kinds and sources of financing of small enterprises are analysed, the estimation of influence of external and internal factors on formation of financial resources of small enterprises is given.

  10. Formation of communication skills of aviation specialists

    OpenAIRE

    Коваленко, Ольга Олександрівна

    2013-01-01

    Culture of the professional communication is the basis of the professional activity. It is spoken about the process of formation of the professional communication culture, where communication, professionalism of the communication are foundation of it in personal oriented studying by means of creative technologies; examined about peculiarities, and defined conditions of formation of professional oral skills culture of future aviation specialists.

  11. Equation of state of water

    Energy Technology Data Exchange (ETDEWEB)

    Ree, F H

    1976-12-20

    An equation of state of water is constructed in the density range between 2 g/m/sup 3/ and 4 x 10/sup 2/ Mg/m/sup 3/ and in the temperature range between 0.025 eV (room temperature) and 25 keV by combining several theoretical codes and experimental data. The liquid-vapor phase change, ionization process, and chemical equilibrium among dissociation products of water are all considered. Theoretical results and experimental data are compared and several interesting aspects of the thermodynamics of water are discussed.

  12. BIOCHEMICAL MECHANISM OF AUTOLYTIC PROCESSES OF MUSCULAR TISSUE OF FISHES

    Directory of Open Access Journals (Sweden)

    L. V. Antipova

    2015-01-01

    Full Text Available The conducted researches allowed to establish that intensive disintegration of a muscular glycogen leads to sharp decrease in size рН muscular tissue in the sour party that in turn affects a chemical composition and physic-colloidal structure of proteins therefore: resistance of meat of fish to action of putrefactive microorganisms increases; solubility of muscle proteins, level of their hydration which is water connecting abilities decreases; there is a swelling of collagen of connecting fabric; activity of the cathepsin (an optimum рН 5,3 causing hydrolysis of proteins at later stages of an autolysis increases; the bicarbonate system of muscular tissue with release of carbon dioxide collapses; predecessors of taste and aroma of meat are formed; process of oxidation of lipids becomes more active. As a result of accumulation dairy, phosphoric and other acids in meat of fish concentration of hydrogen ions of that decrease рН is result increases. Sharply shown sour environment and availability of inorganic phosphorus is considered the reason of disintegration of an actin-myosin complex on actin and a myosin which begins after 8 hours of storage, i.e. there comes the period of relaxation of muscle fibers and the period of permission of an numbness, and then the last stage of maturing of meat – deep autolysis. Thus, on the basis of classical ideas of biochemical changes of meat of land animals and summarizing the obtained data on posthumous changes in muscular tissue of fishes, it is possible to draw a conclusion that they have similar nature of regularity in comparison with muscular tissue of land animals, but their main difference is higher speed of course of autolytic transformations. It in turn leads to faster change of FTS of meat of fishes who are the defining indicators when developing assortment groups of products taking into account stages of an autolysis in meat.

  13. Statistics of Centroids of Velocity

    CERN Document Server

    Esquivel, A

    2009-01-01

    We review the use of velocity centroids statistics to recover information of interstellar turbulence from observations. Velocity centroids have been used for a long time now to retrieve information about the scaling properties of the turbulent velocity field in the interstellar medium. We show that, while they are useful to study subsonic turbulence, they do not trace the statistics of velocity in supersonic turbulence, because they are highly influenced by fluctuations of density. We show also that for sub-Alfv\\'enic turbulence (both supersonic and subsonic) two-point statistics (e.g. correlation functions or power-spectra) are anisotropic. This anisotropy can be used to determine the direction of the mean magnetic field projected in the plane of the sky.

  14. Morphometric justification of algorithm of the choice of method of surgical treatment of dysplastic coxarthrosis

    Directory of Open Access Journals (Sweden)

    Norkin I.A.

    2015-06-01

    Full Text Available Purpose: to define regularities of variability of bone structures of a hip joint depending on type of dysplastic coxarthrosis and to develop tactics of total endoprosthesis replacement. Objects of research. 106 patients with dysplastic coxarthrosis of varying severity, passing treatment on the basis of Federal State Budget Institution of Saratov Scientific Research Institute of Traumatology and Orthopedics from 2005 to 2014 applying methods X, KT-, MRT-metry variation and statistical methods. Results: According to anatomic features of a hip joint at dysplastic coxarthrosis of various types algorithms of choice of acetabularand femoral components of endoprosthesis, and also tactics of total endoprosthesis replacement in groups of research are developed. Conclusion. The choice of a standard size of an endoprosthesis of a hip joint needs to be carried out taking into account X-ray anatomic features of a hip joint and degree of expressiveness of the dysplastic changes. At dysplastic coxarthrosis of the l-ll types it is necessary to carry out standard total endoprosthesis replacement; at coxarthrosis of the III type —total endoprosthesis replacement in combination with plasticity of a roof of acetabular hollow; at coxarthrosis of the IV type — total endoprosthesis replacement in a combination from the shortening femur osteotomy.

  15. Forming of the system of the financial providing of innovative development of economy of Republic of Belarus

    Directory of Open Access Journals (Sweden)

    E.A. Mjatnikova

    2011-01-01

    Full Text Available The major condition of efficiency of realization of innovative projects and programs is their financial maintenance. In article the analysis of use of various sources of financing and the state preferences is carried out by working out and realization of innovative projects and programs. Assumptions on formation of uniform system of financial maintenance of innovative development of economy of Belarus are stated.

  16. Measurement of \

    CERN Document Server

    Aguilar-Arevalo, A A; Bazarko, A O; Brice, S J; Brown, B C; Bugel, L; Cao, J; Coney, L; Conrad, J M; Cox, D C; Curioni, A; Djurcic, Z; Finley, D A; Fleming, B T; Ford, R; Garcia, F G; Garvey, G T; Gonzales, J; Grange, J; Green, C; Green, J A; Hart, T L; Hawker, E; Imlay, R; Johnson, R A; Karagiorgi, G; Kasper, P; Katori, T; Kobilarcik, T; Kourbanis, I; Koutsoliotas, S; Laird, E M; Linden, S K; Link, J M; Liu, Y; Louis, W C; Mahn, K B M; Marsh, W; Mauger, C; McGary, V T; McGregor, G; Metcalf, W; Meyers, P D; Mills, F; Mills, G B; Monroe, J; Moore, C D; Mousseau, J; Nelson, R H; Nienaber, P; Nowak, J A; Osmanov, B; Ouedraogo, S; Patterson, R B; Pavlovic, Z; Perevalov, D; Polly, C C; Prebys, E; Raaf, J L; Ray, H; Roe, B P; Russell, A D; Sandberg, V; Schirato, R; Schmitz, D; Shaevitz, M H; Shoemaker, F C; Smith, D; Soderberg, M; Sorel, M; Spentzouris, P; Spitz, J; Stancu, I; Stefanski, R J; Sung, M; Tanaka, H A; Tayloe, R; Tzanov, M; Van de Water, R G; Wascko, M O; White, D H; Wilking, M J; Yang, H J; Zeller, G P; Zimmerman, E D

    2009-01-01

    MiniBooNE reports the first absolute cross sections for neutral current single \\pi^0 production on CH_2 induced by neutrino and antineutrino interactions measured from the largest sets of NC \\pi^0 events collected to date. The principal result consists of differential cross sections measured as functions of \\pi^0 momentum and \\pi^0 angle averaged over the neutrino flux at MiniBooNE. We find total cross sections of (4.76+/-0.05_{stat}+/-0.40_{sys})*10^{-40} cm^2/nucleon at a mean energy of =808 MeV and (1.48+/-0.05_{stat}+/-0.14_{sys})*10^{-40} cm^2/nucleon at a mean energy of =664 MeV for \

  17. Effects of

    OpenAIRE

    Gowthaman, S.; A. P. Sathiyagnanam

    2016-01-01

    This work investigates the effect of both inlet air temperature and fuel injection pressure on performance and emission behaviour of homogeneous charge compression ignition engine (HCCI) fuelled with diesel fuel. In this investigation, HCCI engine operates with different inlet air temperature and fuel injection pressure, and analysis the effect of these variables on HCCI engine performance and emissions. The inlet air temperatures are varied between 40 °C and 70 °C and the injection pressure ...

  18. Rationalization of work of leaders of physical-sports organizations

    Directory of Open Access Journals (Sweden)

    Galina Putiatina

    2016-02-01

    Full Text Available Purpose: to create the main ways of rationalization of the work of heads of physical-sports organizations in the structure of their scientific organization of the work. Material & Methods: the content of the administrative activity of representatives of the system of the regional government of the sphere of physical culture and sport of the Kharkov area, and also directors of sports schools of Kharkov (57 respondents are generalized. Methods – the analysis of references, the organizational analysis, the organizational diagnosis, the poll (questioning, the methods of mathematical statistics. Results: the essence and the content of rationalization of the administrative work in the sphere of physical culture and sport are considered. The integrated approach to certain objects of rationalization of the administrative work is established in physical-sports organizations. Conclusions: the main ways of rationalization of the work of heads of physical-sports organizations are: the organization of work concerning the development of motivational mechanisms of the activity of heads; the increase of the economic appeal of work; the formation of ideology of a healthy lifestyle.

  19. Mapping of

    Directory of Open Access Journals (Sweden)

    Sayed M. Arafat

    2014-06-01

    Full Text Available Land cover map of North Sinai was produced based on the FAO-Land Cover Classification System (LCCS of 2004. The standard FAO classification scheme provides a standardized system of classification that can be used to analyze spatial and temporal land cover variability in the study area. This approach also has the advantage of facilitating the integration of Sinai land cover mapping products to be included with the regional and global land cover datasets. The total study area is covering a total area of 20,310.4 km2 (203,104 hectare. The landscape classification was based on SPOT4 data acquired in 2011 using combined multispectral bands of 20 m spatial resolution. Geographic Information System (GIS was used to manipulate the attributed layers of classification in order to reach the maximum possible accuracy. GIS was also used to include all necessary information. The identified vegetative land cover classes of the study area are irrigated herbaceous crops, irrigated tree crops and rain fed tree crops. The non-vegetated land covers in the study area include bare rock, bare soils (stony, very stony and salt crusts, loose and shifting sands and sand dunes. The water bodies were classified as artificial perennial water bodies (fish ponds and irrigated canals and natural perennial water bodies as lakes (standing. The artificial surfaces include linear and non-linear features.

  20. Directions of improvement of account of factoring operations

    OpenAIRE

    2015-01-01

    With the height of competition on commodity markets the suppliers of commodities and services for bringing in of new and maintenance of present clients are forced to give certain privileges to them, including postponement or arranging on the installment system of payment. In these terms one of perspective instruments of financing of enterprises of the real sector is factoring. Factoring  plays an important role in a market economy. He provides to the enterprises and organizations of height of...

  1. IMPROVEMENT OF THE PRINCIPLES OF THE ORGANIZATION OF INSPECTION AND SUPERVISING ACTIVITY OF BANK OF RUSSIA

    Directory of Open Access Journals (Sweden)

    Виктор Макарович Заернюк

    2013-04-01

    Full Text Available In article established practices of the organization of control and supervision of Bank of Russia of activity of the Russian commercial banks are considered.  The analysis is carried out and the assessment of a level of development of a substantial component of bank regulation and supervision is given.Purpose: Research of tendencies and problems in the organization of control and supervising activity of Bank of Russia at the present stage.Methodology: General scientific methods were used: analysis and synthesis, comparisons, generalizations, system approach. In the course of use of the actual material methods of the economical and statistical analysis were used.Results: The conclusion that the excessive and bureaucratized control from the Central bank interferes with dynamic development of the banking sector is drawn. It is required to generation of the new thinking which is expressing in transfer of accent from need of strict, in many respects of formal, application of bank instructions and regulations on formation of professional opinion of the controler, increase of its responsibility for results of checks.DOI: http://dx.doi.org/10.12731/2218-7405-2013-3-1

  2. Kinetics of microwave drying of apples

    Directory of Open Access Journals (Sweden)

    G. V. Kalashnikov

    2012-01-01

    Full Text Available The influence of main technological parameters was studied as a result of research of microwave drying of apples and the analysis of kinetic regularity of the process was performed.

  3. [ABOUT UNIFICATION OF LABORATORY CRITERIA OF DIFFERENTIATION OF BACTERIAL VAGINOSIS].

    Science.gov (United States)

    Mavzutov, A R; Tsvetkova, A V; Muretdinova, L A

    2015-06-01

    The article presents analysis of laboratory criteria and classifcations used to interpret results of laboratory analysis by technique of microscopy on bacterial vaginosis or dysbacteriosis of vagina. Their advantages and restrictions are demonstrated The unified criteria of evaluation are proposed concerning results of microscopy of mucosal discharge of vagina and corresponding classification. Thereafter, three degrees of bacterial vaginosis (dysbacteriosis of vagina) are differentiated: first degree--compensated dysbacteriosis of vagina, second degree--sub compensated dysbacteriosis of vagina and third degree--decompensated dysbacteriosis of vagina. The corresponding laboratory report of physician is formulated. The proposals are presented concerning development of common unified requirements to stages (pre-analytical, analytical, post-analytical) of laboratory diagnostic of bacterial vaginosis (dysbacteriosis of vagina) with purpose of their unambiguous understanding by clinicians and hence their decision making concerning necessity and tactics of management of patient.

  4. Planning of process of physical education of students.

    Directory of Open Access Journals (Sweden)

    Pylypey L.P.

    2012-09-01

    Full Text Available Going is considered near the personality oriented system professionally-applied physical training of students. In an experiment 500 students of 1-3 courses took part in age from 17 to 23 years. In research of motivation to employments 52 students took part 3 courses. The results of cross-correlation analysis of computer-integrated indexes of level of physical training are resulted. Aims, functions of structure, typology and principles of physical education, are certain. Progress of professional training trends are exposed. The organizational and methodical aspects of construction of the system of physical education are recommended. Directions of planning of educational process are offered on physical education on the basis of professionally-applied physical training of students. Attention is accented on the necessity of exposure of terms for realization of creative capabilities of teacher, leaders and students.

  5. TECHNOLOGICAL LEVEL OF PRODUCTION OF RUSSIAN ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Galina S. Sagieva

    2015-01-01

    Full Text Available The article presents an analysis of the technological level of production of Russian organizations. Areas of study cover the characteristics of the use of technology in manufacturing (the extent of use and level of technology, the problems solved by using specific types of technologies and the use in the production process of intellectual property; factors driving growth of technological level of the surveyed medium and large organizations and provides them with a competitive advantage

  6. Theoretical aspects of competitiveness of the industry of mineral water

    Directory of Open Access Journals (Sweden)

    E.M. Azarian

    2014-03-01

    Full Text Available The aim of the article. The article presents theoretical aspects of the concept and content of economic competitiveness for its competitive positions. Authors found positive trends, essential trends of increasing the competitiveness of the food industry as a complex system. The article shows theoretical basis for the competitiveness of the industry of mineral water, clarifies the concepts of competitiveness. Authors suggest development of the main directions of improving the competitiveness of the food complex sector. The results of the analysis. Authors generalized theoretical experience of the concept and scope of the use of the methodology of competitiveness; analysis of the competitiveness of the industry of mineral water, revealed positive trends; developed the main directions of improving the competitiveness of the sector in food complex. Analysis of the mineral waters of Ukraine reveals the following competitive advantages: the ability to produce high quality products with an unique competitive advantage. Creating favorable conditions relevant resources and innovation of enterprises in order to increase their profitability, improve the culture of consumption of mineral water Ukrainian production, the elimination of the innovative and trend- to-market at the optimum time dictated by the marketing activity and consumer demand. Interaction with competitive firms, leaders of the study and implementation of international experience in the production and marketing strategy and sales, cooperation within the industry and with other industries in the country and with similar industries abroad, presence of unique recipes, advanced manufacturing, processing its own base; infrastructure. Conclusions and directions of further researchers. There is an intensive foreign investment in the development of the industry of mineral water. Formation of the state of quality and safety, monitoring compliance with in terms of quality and security of mineral

  7. [Prevention of complications of IUDs].

    Science.gov (United States)

    Henrion, R

    1980-11-01

    Complications resulting from IUD use are essentially of 4 types: 1) uterine perforation, either at the time of insertion or by translocation of the device. Perforations can be avoided by exercising the utmost attention at time of insertion, and by choosing the proper time of insertion, usually postmentruation. It is also imperative that the IUD be right for the uterine cavity size; 2) pelvic infection, the most serious of IUD complications, since it can, however rarely, cause death; it is absolutely necessary to observe the strictest asepsy during IUD insertion; 3) menorrhagia, which, when severe, can cause anemia. Women with heavy menstrual flow should not wear an IUD; and, 4) ectopic pregnancy, which usually ends in spontaneous abortion, but which can cause infection.

  8. Mechanisms of action of angiogenin

    Institute of Scientific and Technical Information of China (English)

    Xiangwei Gao; Zhengping Xu

    2008-01-01

    Angiogenin induces angiogenesis by activating vessel endothelial and smooth muscle cells and triggering a number of biological processes,including cell migration,invasion,proliferation,and formation of tubular structures.It has been reported that angiogenin plays its functions mainly through four pathways:(1) exerting its ribonucleolytic activity;(2)binding to membrane actin and then inducing basement membrane degradation;(3) binding to a putative 170-kDa protein and subsequently transducing signal into cytoplasm;and (4) transiocating into the nucleus of target cells directly and then enhancing ribosomal RNA transcription.Angiogenin can also translocate into the nucleus of cancer cells and induces the corresponding cell proliferation.Furthermore,angiogenin has neuroprotective activities in the central nervous system and the loss of its function may be related to amyotrophic lateral sclerosis.This review intends to conclude the mechanisms underlying these actions of angiogenin and give a perspective on future research.

  9. Rationalisation of Management of Strategic Option of an Enterprise

    Directory of Open Access Journals (Sweden)

    Chechetova-Terashvili Tetyana M.

    2013-12-01

    Full Text Available The article analyses the state of management of domestic corporate enterprises by such features: nature of management, management functions, spheres of activity, efficiency of activity and priority directions of development. It outlines problems of non-correspondence of requirements of the highly competitive environment and existing models of management. It analyses the procedure of formation of managerial competences at the level of subjects of corporate relations, in the basis of which there is identification of their functions and criteria of efficiency of activity. It identifies a necessity of the study of managerial competences through allocation of corporate management subjects, authorities of which are outlined by goals of efficient management, protection of shareholders’ rights, ensuring observation of rights of interested persons, protected by law and international regulatory rules, ensuring modern and correct disclosure of information by all existing issues that have to do with the JSC activity. It justifies a set of measures on the search for efficient decisions on accumulation and use of managerial knowledge by means of creation of a portfolio of alternatives in correspondence with certain criteria.

  10. Statistical assessment of quality of credit activity of Ukrainian banks

    Directory of Open Access Journals (Sweden)

    Moldavska Olena V.

    2013-03-01

    Full Text Available The article conducts an economic and statistical analysis of the modern state of credit activity of Ukrainian banks and main tendencies of its development. It justifies urgency of the statistical study of credit activity of banks. It offers a complex system of assessment of bank lending at two levels: the level of the banking system and the level of an individual bank. The use of the system analysis allows reflection of interconnection between effectiveness of functioning of the banking system and quality of the credit portfolio. The article considers main aspects of management of quality of the credit portfolio – level of troubled debt and credit risk. The article touches the problem of adequate quantitative assessment of troubled loans in the credit portfolios of banks, since the methodologies of its calculation used by the National Bank of Ukraine and international rating agencies are quite different. The article presents a system of methods of management of credit risk, both theoretically and providing specific examples, in the context of prevention of occurrence of risk situations or elimination of their consequences.

  11. INDICTORS OF RESTORATION OF PROGRAM FACILITY OF MECHATRONICS SYSTEM

    OpenAIRE

    Frolov, V.

    2009-01-01

    The determination of reliability indictors of program facilities of mechatronic systems are offered. The defaillance modes of program facilities are represent. A short review of model reliability of program facility is presented. The indictors of restoration, their mathematical determinations and application for the characteristics of program facility restoration are offered.

  12. INDICTORS OF RESTORATION OF PROGRAM FACILITY OF MECHATRONICS SYSTEM

    Directory of Open Access Journals (Sweden)

    V. Frolov

    2009-01-01

    Full Text Available The determination of reliability indictors of program facilities of mechatronic systems are offered. The defaillance modes of program facilities are represent. A short review of model reliability of program facility is presented. The indictors of restoration, their mathematical determinations and application for the characteristics of program facility restoration are offered.

  13. Theoretical Substantiation of Formation of Integration Forms of Interaction of Enterprises when Developing the Innovation Policy

    Directory of Open Access Journals (Sweden)

    Manoylenko Oleksandr V.

    2014-01-01

    Full Text Available The article considers issues, connected with activation of innovation activity of engineering enterprises on the basis of application of integration forms of interaction. It justifies a necessity of formation of infrastructure of interaction of an enterprise when introducing innovation models of development with consideration of realisation of goals of all interested parties. The article offers a generalised scheme of organisational interaction of an enterprise in external environment and a matrix of functional provision of the integration process. The theoretical approach that is considered in the article allows increase of innovation activity of engineering enterprises and minimisation of expenditures of own resources when realising innovation policy of an enterprise.

  14. Genome of

    NARCIS (Netherlands)

    Santini, S.; Jeudy, S.; Bartoli, J.; Poirot, O.; Lescot, M.; Abergel, C.; Barbe, V.; Wommack, K.E.; Noordeloos, A.A.M.; Brussaard, C.P.D.; Claverie, J.M.

    2013-01-01

    Large dsDNA viruses are involved in the population control of many globally distributed species of eukaryotic phytoplankton and have a prominent role in bloom termination. The genus Phaeocystis (Haptophyta, Prymnesiophyceae) includes several high-biomass-forming phytoplankton species, such as Phaeoc

  15. Measurement of \

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar-Arevalo, A.A.; /Mexico U., ICN; Anderson, C.E.; /Yale U.; Bazarko, A.O.; /Princeton U.; Brice, S.J.; /Fermilab; Brown, B.C.; /Fermilab; Bugel, L.; /Columbia U.; Cao, J.; /Michigan U.; Coney, L.; /Columbia U.; Conrad, J.M.; /MIT; Cox, D.C.; /Indiana U.; Curioni, A.; /Yale U. /Columbia U.

    2009-11-01

    MiniBooNE reports the first absolute cross sections for neutral current single {pi}{sup 0} production on CH{sub 2} induced by neutrino and antineutrino interactions measured from the largest sets of NC {pi}{sup 0} events collected to date. The principal result consists of differential cross sections measured as functions of {pi}{sup 0} momentum and {pi}{sup 0} angle averaged over the neutrino flux at MiniBooNE. We find total cross sections of (4.76 {+-} 0.05{sub stat} {+-} 0.40{sub sys}) x 10{sup -40} cm{sup 2}/nucleon at a mean energy of = 808 MeV and (1.48 {+-} 0.05{sub stat} {+-} 0.14{sub sys}) x 10{sup -40} cm{sup 2}/nucleon at a mean energy of = 664 MeV for {nu}{sub {mu}} and {bar {nu}}{sub {mu}} induced production, respectively. In addition, we have included measurements of the neutrino and antineutrino total cross sections for incoherent exclusive NC 1{pi}{sup 0} production corrected for the effects of final state interactions to compare to prior results.

  16. of Metronidazole

    Directory of Open Access Journals (Sweden)

    Md. Lutful Amin

    2016-06-01

    Full Text Available Purpose: The purpose of this study was to develop and evaluate metronidazole loadedfloating-mucoadhesive microsphere for sustained drug release at the gastric mucosa.Methods: Alginate gastroretentive microspheres containing metronidazole were preparedby ionic gelation method using sodium bicarbonate as gas forming agent, guar gum asmucoadhesive polymer, and Eudragit L100 as drug release modifier. Carbopol was used forincreasing the bead strength. The microspheres were characterized by scanning electronmicroscopy and evaluated by means of drug entrapment efficiency, in vitro buoyancy, andswelling studies. In vitro mucoadhesion and drug release studies were carried out in order toevaluate site specific sustained drug release.Results: All formulations showed 100% buoyancy in vitro for a prolonged period of time.Amount of guar gum influenced the properties of different formulations. The formulationcontaining drug and guar gum at a ratio of 1:0.5 showed the best results with 76.3% drugentrapment efficiency, 61.21% mucoadhesion, and sustained drug release. Carbopol wasfound to increase surface smoothness of the microspheres.Conclusion: Metronidazole mucoadhesive-floating microspheres can be effectively usedfor sustained drug release to the gastric mucosa in treatment of upper GIT infection.

  17. Zeros of entire functions of finite order

    Directory of Open Access Journals (Sweden)

    Supper Raphaële

    2002-01-01

    Full Text Available Given , , let be the set of all entire functions , with , for which there exists some constant such that . It is shown that the zero set of a function of satisfies and that the union of the zero sets of two functions of is not necessarily the zero set of a function of . Some uniqueness results of Carlson's type are also obtained.

  18. Calculation of Thermochemical Constants of Propellants

    Directory of Open Access Journals (Sweden)

    K. P. Rao

    1979-01-01

    Full Text Available A method for calculation of thermo chemical constants and products of explosion of propellants from the knowledge of molecular formulae and heats of formation of the ingredients is given. A computer programme in AUTOMATH-400 has been established for the method. The results of application of the method for a number of propellants are given.

  19. OF THE IMPLEMENTATION OF A GOVERNMENT PROGRAMS

    Directory of Open Access Journals (Sweden)

    Skaryupina, M.B.

    2016-04-01

    Full Text Available This article describes the problem and the need for monitoring of the government program effectiveness, conceptual model of monitoring during the implementation of the state program. Also the author presented a software module for monitoring of implementation of the government programs and gave a description of the main elements of an effective monitoring system of implementation of the government program.

  20. Influence of motive activity on forming of proof skills of healthy way of life of students of higher educational establishments.

    Directory of Open Access Journals (Sweden)

    Trotsenko V.V.

    2010-08-01

    Full Text Available The estimation and the analysis of impellent activity of students is considered. The importance of impellent activity in forming a healthy way of life of students is shown. In research the data of questionnaire of students are used. sports priorities of students are revealed should to undertake in attention by development of the program of physical training. The wide spectrum of the reasons which interfere with exercises is revealed. These reasons should be considered during individual work with each student. It is proved, that impellent activity influences forming of proof skills of a healthy way of life of students.

  1. Estimation of efficiency of virtual productive enterprise functioning with the use of concept of hyperstability

    Directory of Open Access Journals (Sweden)

    Sobchak Andrii

    2016-02-01

    Full Text Available The concept of hyperstability of the cybernetic system is considered in an appendix to the task of estimation of efficiency of virtual productive enterprise functioning. The basic factors, influencing on efficiency of functioning of such enterprise are determined. The article offers the methodology of synthesis of static structure of the system of support of making decision by managers of virtual enterprise, in particular procedure of determination of numerical and high-quality strength of equipment, producible on a virtual enterprise.

  2. Elements of mechanics of materials

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, G.A.

    1982-01-01

    The study of mechanics of materials as pursued in this text involves the development and application of those basic design relationships which occur in the more simple stress-resisting bodies. Chapters are included on stresses in members subjected to axial and central loads; stress-strain data and structural materials property data obtained by experimentation; stresses in thin-walled cylinders, spheres, and fabricated joints; shear- and bending-moment diagrams, beam design and deflections; stresses due to eccentrically applied loads; columns; combined stresses and strains; fatigue; and energy relationships and impact loads. This text was designed for use in a comprehensive one-semester undergraduate course in mechanics of materials. (LCL)

  3. The general of the precondition of success of physical training of students of special medical group.

    Directory of Open Access Journals (Sweden)

    Babenko V.G.

    2011-12-01

    Full Text Available The system of physical education of students is considered. Health influence of the organized forms of employments is rotined by physical exercises on the organism of students. The conceptual going opens up near the mechanism of functioning of the system of physical education under various conditions of activity. It is set that the existent systems of strengthening of health and maintenance of the proper physical standards have close intercommunication. They depend on the preliminary formed positive motivation of students to perfection and self-perfection of physical culture and sport facilities. It is recommended to conduct employments in the close co-operating with other educational disciplines under the direction of experimental specialists of medicine and physical education.

  4. IMPLEMENTATION OF INNOVATIVE PROSPECTS OF THE LABOR MARKET OF UKRAINE

    Directory of Open Access Journals (Sweden)

    V. Chuvardynskyi

    2015-10-01

    Full Text Available The foreign experience of the provision of innovative development of labour market was investigated. The current tendencies of the development of labour market segments were analyzed. The main problems of the providing of the possibilities of innovative prospects of labour market development realization were defined. The most important reason is the saving of the significant share of low-effective labour in the occupational and qualification structure of labour force. The ways of the realization of innovative prospects of labour market development due to growth of quality of educational services on the basis of “life-long education” formation aimed on optimization of the occupational and qualification structure of labour force were defined.

  5. Diversity of

    Directory of Open Access Journals (Sweden)

    Mohamed M. Abou Zaid

    2014-01-01

    Full Text Available Seasonal abundance, biomass, and taxonomic composition of copepods in El-Mex Bay (Southeastern Mediterranean region were studied from autumn 2011 to 2012. Most species within the copepod communities displayed a clear pattern of succession throughout the investigation period. Generally copepods were the predominant group. They contributed numerically 57% of the total zooplankton counts with an average of 5083 organisms/m3 and a total number of 203,333 individuals. The bay harbored 50 species belonging to 28 genera within 19 families and 4 orders under one class. Calanoids were represented by 24 species which formed 31.6% of total copepods predominantly Acartia clausi, Calocalanus pavo, Clausocalanus furcatus, Eucalanus crassus, Nannocalanus minor, Paracalanus parvus, Eucalanus subcrassus, and Temora longicornis. Cyclopoids comprised 13 species of which Acanthocyclops americanus, Halicyclops magniceps, Oithona attenuata, and Oithona nana were the most abundant adult copepods. Eleven Harpacticoid species were also recorded with Euterpina acutifrons, Microsetella norvegica, Onychocamptus mohammed being the most prevalent. It was found however, that two Poecilostomatoida species were rarely encountered in the plankton Oncaea minuta and Corycaeus typicus. Copepod larvae and copepodite stages formed the main bulk of copepod Fauna as noticed in the El-Mex Bay during the investigation period. Their percentage was 36.7% of the total count and their total numbers were 74,629 individuals with an average of 1866 organisms/m3. The persistent relationships between total copepod counts, copepod orders, and physico-chemical variables suggested that physical factors operate on the copepod communities, either directly to limit maximum distribution along the bay, or indirectly on abundance.

  6. Performance of

    Directory of Open Access Journals (Sweden)

    Naema A. Ali

    2015-09-01

    Full Text Available Soil collapse occurs when increased moisture causes chemical or physical bonds between the soil particles to weaken, which allows the structure of the soil to collapse. Collapsible soils are generally low-density, fine-grained combinations of clay and sand left by mudflows that have dried, leaving tiny air pockets. When the soil is dry, the cemented materials are strong enough to bond the sand particles together. When natural soil becomes wet, moisture alters the cementation structure and the soil’s strength is compromised, causing collapse or subsidence. Based on soil type and density, the potential for encountering collapsible soils throughout most of the project alignment is low. Conditions in arid and semi-arid climates like Borg El Arab, near Alexandria Egypt favor the formation of the most problematic collapsible soils. The behavior and performance of compacted sand replacement over treated collapsible soil by pre-wetting and compaction are investigated in the current study. Field investigation was performed in the form of plate loading tests conducted on compacted sand replacement over improved collapsible soil. Field plate load tests program was developed to explore the effect of compacted sand replacement thickness on collapsibility potential. Treated collapsible soil was replaced with imported cohesionless soil with variable thickness up to footing width. Results proved that the improvement of collapsible soils by sand/crushed stone replacement is possible to control/mitigate their risk potentials against sudden settlement when exposed to water. Replacement soil increases the rate and reduces the amount of footing settlement. For compacted collapsible soils, partial replacement by compacted sand/crushed stone layers decreases collapsibility potential risk. Results also, introduce the development of practical, economical and environmentally safe geochemical methods for collapsible soil stabilization and collapsible risk mitigation.

  7. Efficiency of application of means of sports preparation of combat sportsmen in physical training of students of technical high school

    Directory of Open Access Journals (Sweden)

    Litvinenko A.M.

    2013-02-01

    Full Text Available The problem of efficiency of application of different volumes of trainings facilities of sporting single combats (on the example of kickboxing is considered in physical education of students. The complexity of influence of facilities of east single combats is shown on sportsmen. In an experiment took part 50 students of first-year of teaching in age 17-18 years. Tests were used: undercutting on a cross-bar, broad jumps from a place, at shuttle run of 4х9 m. Positive intercommunication of increase of volume of the training loading is shown by effectiveness of pedagogical process. It is set that increase of number of employments by students in kickboxing to three one time per a week allows for certain to improve the indexes of physical preparedness on the chosen tests. The higher level of technical preparedness of students is statistically confirmed applying the greater amount of physical exercises, sent to forming of skills of kickboxing. Distribution of students is educed on the tactical types of conduct of competition fight: 36 % is a playing manner, 44 % is a rate manner, 8 % is a manner of slog, 12 % is an universal manner. Offered to recommendation on the correction of volume of loading for the increase of didactic potential of employments on physical education.

  8. IMPROVEMENT OF SYSTEM OF MATERIAL STIMULATION AND MATERIAL ENCOURAGEMENT OF WORK OF HEALTH WORKERS

    Directory of Open Access Journals (Sweden)

    Elena Vladimirovna Deryabina

    2015-12-01

    Full Text Available In article are considered possibilities of a solution of the problem of quality of medical services by improvement of system of material stimulation and encouragement of health workers. Are developed the methodical recommendations about material stimulation and encouragement of work of medical personnel directed on increase of individual and collective productivity, improvement of quality of medical services.

  9. Estimation of quality of labour life of personnel: method and possibilities of its application

    OpenAIRE

    Kompaniets, V.

    2009-01-01

    An author offers of principle a new method of estimation of level of quality of labour life of personnel, which takes into account sotsiokulturniy approach. It is based on vision of necessities of man and realization of them in labour from point of christianity, on the basis of which mentality was formed of our peoples, its economic culture.

  10. METHODOLOGY OF AN ASSESSMENT OF RESULTS OF INTELLECTUAL ACTIVITY

    OpenAIRE

    Larisa I. Egorova; Elizaveta S. Sokolova; Galina V. Shadrina

    2013-01-01

    The methodological bases of an assessment of the results of research, development and technological works and intangible assets are given in the article. A special attention is paid to the problems of formation of fair value of such assets for clients of financial accounting. The authors compare the methods of cost measurement of accounting entities regulated by Russian Accounting Standards (RAS) and International Financial Reporting Standards (IFRS). Peculiarities of detection and acknowledg...

  11. Individual properties of personality as criterion of choice of style of game of tennis players

    Directory of Open Access Journals (Sweden)

    Shalar O.G.

    2013-02-01

    Full Text Available The features of different styles of game are considered in table tennis and intercommunication with individual psychological properties of personality of tennis players is shown. Characterological and intellectual indexes of sportswomen of high class, which come forward in club championship of Ukraine on table tennis, is studied. 15 sportswomen of high class, among which a 1 master of sport of international class, 7 masters of sport and 7 candidates in masters of sport, took part in research. It is set that the excitable (100 % is inherent the tennis players of attacking style of game, hyperthymic, emotive and ecstatic (80 % type of accentuation and brightly expressed persistence. Hyperthymic prevails for the tennis players of the combined style of game, emotive, cyclothymic and demonstrative (100 %, anxious and excitative (80 % type of accentuation. Tennis players-defenders have a sense to hyperthymic, emotive and to ecstatic (100 %, anxious, to the cyclothymic (80 % type of accentuation. Tennis players of the combined and protective style of game are in 80 % cases have a high level of intellectual capabilities. However more expressed motivation to success is for the tennis players of attacking style of game (60 %.

  12. [THE PERSPECTIVES OF STUDYING OF POLYMORPHISM OF GENES OF GAMMA-INTERFERON UNDER CHRONIC BRUCELLOSIS].

    Science.gov (United States)

    Nurpeisova, A Kh; Kolomeietz, A N

    2016-02-01

    The brucellosis is an actual zoonotic disease in many countries, Russia included. The complexity of individual prognosis of disease and choice of tactics of maintenance of patients is explained by heterogeneity of clinical manifestations of brucellosis and different rate of progression of organs pathology. Despite of low mortality, this pathology quite often results in disability of patient. The frequent transition of acute process into chronic one (40-60%), probability of development of primary chronic brucellosis determines interest of researchers to issues of immunopathogenesis of this disease. The article presents review of achievements in studies of polymorphism of genes of gamma-interferon in the given area.

  13. Programming of employments physical exercises for the improvement of bodily condition of children of midchildhood.

    Directory of Open Access Journals (Sweden)

    Sljusarchuk V.V.

    2011-12-01

    Full Text Available Approaches are considered on forming and realization of maintenance of physical education of students of initial school. The algorithm of programming of maintenance of lessons of physical culture is developed. The program foresees implementation of requirements of general and methodical principles of physical education, positions of theory of adaptation, requirements of the operating program. It is marked that employments must provide for: differentiated going near students, account of interests and to the wishes, motivation to independent employments by physical exercises, to providing of motor high-density. It is recommended to take into account the features of dynamics of indexes of bodily condition of children of different somatotype.

  14. Directions of improvement of account of factoring operations

    Directory of Open Access Journals (Sweden)

    V.I. Kuz

    2015-06-01

    Full Text Available With the height of competition on commodity markets the suppliers of commodities and services for bringing in of new and maintenance of present clients are forced to give certain privileges to them, including postponement or arranging on the installment system of payment. In these terms one of perspective instruments of financing of enterprises of the real sector is factoring. Factoring plays an important role in a market economy. He provides to the enterprises and organizations of height of volume of turnover means and acceleration of circulating of capital; assists more rapid redemption a debtor and creditor debts and as a result, height of rates of production and circulating of commodities, works or services; assists expansion of production. How a process of development of factoring operations is intensive enough, a necessity grows for the detailed consideration of methodology of record-keeping of factoring operations. Methodology of record-keeping of factoring operations offered in the article for a supplier, at a factor and debtor, on the basis of operating card of accounts can be used in practice of commercial organizations-participants of agreement of factoring.

  15. Stages of Formation of the Strategy of Social Responsibility of Business

    Directory of Open Access Journals (Sweden)

    Zatieyshchykova Olha O.

    2014-02-01

    Full Text Available The article studies existing approaches to formulation of stages of the strategy, according to which a list of stages of formation of the strategy of social responsibility (SSR is formed, including: identification of the mission and vision of SSR, formation of the system of goals of SSR, assessment of influence of factors of external environment, assessment of the level of social responsibility, analysis of alternatives and selection of strategies. The article identifies SSR mission for Ukrainian enterprises, which lies in increase of the quality of life of employees, local society and society in general. SSR vision – improvement of effectiveness of business and profitability indicators on the basis of creation of trustworthy relations between business, society and state. The article develops the goals tree of SSR that has goals of three levels. It identifies a list of factors of external environment, including: growing anxiety about the state of environment and demographic situation, level of education and culture, growing intensity of competition, level of income and wellbeing, active participation of the state policy in the use of principles of social responsibility, propaganda of social responsibility within the impact area, fast change of technologies, fair marketing practice, informing and executing agreements. The article offers to assess the level of social responsibility on the basis of calculation of indicators of social investments both by quantitative and qualitative methods and calculation of indicators of voluntary social responsibility of business. It also offers main components of the essence of the SSR strategy.

  16. Features of empathy of students of pedagogical specialties

    Directory of Open Access Journals (Sweden)

    Galina Bezverkhnya

    2014-08-01

    Full Text Available Purpose: to define levels of empathy at students. Material and methods: levels of the manifestation of empathy are studied at students of faculty of the primary education of full-time education and correspondence course (120 persons. The technique of the definition of empathy of I. M. Yusupov was used. Results: the reliable decrease is revealed in the level of empathy to children from the II to the IV course of the full-time education. On the correspondence course the level of empathy to children remains stable on the II and the IV courses. Conclusions: this technique of the definition of the level of empathy allows to judge the professional suitability of those who chooses a pedagogical profession, and helps to define, what profession shouldn't be chosen by graduates of schools because of the incompatibility with the object of the future professional activity.

  17. "Space of physics journals": in search of journals of quality

    CERN Document Server

    Katchanov, Yurij L

    2016-01-01

    This paper analyses the problem of scientific quality of physics journals. The main assumption is that the quality of a physics journal exists only in reference to other journals. Instead of constructing new indicators of scientific quality, we identify a physical journal with corresponding empirical distribution function of citations. From our relational point of view, the space of physics journals is only a system of differences between empirical distribution functions of citations. Using data from Web of Science Core Collection we consider the space of physics journals and the space of scientific publishers. The first provides an objective basis for the grouping of physics journals on the basis of a whole range of indicators (citation statistics, country, publisher, etc.). The second reveals the "competitors' triangle" of regional publishers, transnational publishers and professional physical societies. These findings have prompted us to advance the hypothesis that the structure of the space of physics jou...

  18. DOCUMENTING OF THE PROCESS OF ACCUMULATION OF KNOWLEDGE AND DEVELOPMENT OF THE INTELLECTUAL HUMAN CAPITAL

    Directory of Open Access Journals (Sweden)

    Yermolenko V. V.

    2015-06-01

    Full Text Available The problem of documenting of process of accumulation of knowledge and development of the intellectual human capital is considered in this article. The purpose of the article is the research of theoretical approaches of documenting of process of accumulation of knowledge, development of the intellectual human capital and the analysis of domestic public corporations on documenting of process of accumulation of knowledge. The solution of research tasks in article is proposed: the analysis of the contents of theories of development of the human capital in the conditions of economy of knowledge is carried out; domestic practice of public corporations on documenting of process of accumulation of knowledge is studied; features of documenting of knowledge as maintenance of development of the human capital are marked out. The particular emphasis in the article is placed on disclosure of such problems, as: methodological and theoretical aspects of development of the intellectual human capital; formation of mechanisms and ways of documenting of knowledge in the conditions of knowledge economy; formation of corporate institutes of formation and the development of the intellectual human capital, realizing reproduction of the intellectual capital and engineering of knowledge; formation of organizational innovations and dumping of old organizational routines. Documenting of knowledge is presented as maintenance of development of the human capital, the project of introduction of knowledge management and its documentary maintenance in corporations, and also ways of network documenting of knowledge of the human capital in the process of joint design activity is offered. Development of a special control system and its organizational and methodical providing which will allow to increase efficiency of work with documents during projects of development of the intellectual human capital is necessary for management of the documentary massif of knowledge of the

  19. Genetic bases of the evolution of organisms

    Directory of Open Access Journals (Sweden)

    Marinković Dragoslav M.

    2002-01-01

    Full Text Available Biological progress consists of the continuous increase of divergence with simultaneous maintenance and the increase of conformance (harmoniousness of living systems. A mutual balance between divergence of forms and the degree of perfection of their structure and function indicates a level of the evolutionary development of a particular group of organisms, i.e. a level and prospects of their evolutionary progress. An enormous potential of combined genetic polymorphousness is reduced to adaptive landscapes of a limited number of developmental programmes that make actual units of inheritance and variability within each species.

  20. Regularity of

    Institute of Scientific and Technical Information of China (English)

    WANG; Wei

    2001-01-01

    [1] Nagaev, A. V., Integral limit theorems for large deviations when Cramer's condition is not fulfilled I, II, Theory Prob. Appl., 1969, 14: 51-64, 193-208.[2] Nagaev, A. V., Limit theorems for large deviations where Cramer's conditions are violated (In Russian), Izv. Akad. Nauk USSR Ser., Fiz-Mat Nauk., 1969, 7: 17.[3] Heyde, C. C., A contribution to the theory of large deviations for sums of independent random variables, Z. Wahrscheinlichkeitsth, 1967, 7: 303.[4] Heyde, C. C., On large deviation probabilities for sums of random variables which are not attracted to the normal law, Ann. Math. Statist., 1967, 38: 1575.[5] Heyde, C. C., On large deviation probabilities in the case of attraction to a nonnormal stable law, Sanky, 1968, 30: 253.[6] Nagaev, S. V., Large deviations for sums of independent random variables, in Sixth Prague Conf. on Information Theory, Random Processes and Statistical Decision Functions, Prague: Academic, 1973, 657674.[7] Nagaev, S. V., Large deviations of sums of independent random variables, Ann. Prob., 1979, 7: 745.[8] Embrechts, P., Klüppelberg, C., Mikosch, T., Modelling Extremal Events for Insurance and Finance, Berlin-Heidelberg: Springer-Verlag, 1997.[9] Cline, D. B. H., Hsing, T., Large deviation probabilities for sums and maxima of random variables with heavy or subexponential tails, Preprint, Texas A&M University, 1991.[10] Klüppelberg, C., Mikosch, T., Large deviations of heavy-tailed random sums with applications to insurance and finance, J. Appl. Prob., 1997, 34: 293.

  1. Damping of roll vibrations of vehicle suspension

    Science.gov (United States)

    Le, K. C.; Pieper, A.

    2014-04-01

    Small forced vibrations of an axle model of independent suspensions having four degrees of freedom are studied. The exact analytical solution of the generalised Lagrange equation enables one to produce 3D plots of the normalised amplitudes of forced vibrations versus frequency and excitation ratio or phase difference of the road inputs. The analysis of these plots exhibits some deficiency in damping of roll vibrations of conventional vehicle suspensions. The possibilities of improvement are discussed.

  2. Quantization of Equations of Motion

    Directory of Open Access Journals (Sweden)

    D. Kochan

    2007-01-01

    Full Text Available The Classical Newton-Lagrange equations of motion represent the fundamental physical law of mechanics. Their traditional Lagrangian and/or Hamiltonian precursors when available are essential in the context of quantization. However, there are situations that lack Lagrangian and/or Hamiltonian settings. This paper discusses a description of classical dynamics and presents some irresponsible speculations about its quantization by introducing a certain canonical two-form ?. By its construction ? embodies kinetic energy and forces acting within the system (not their potential. A new type of variational principle employing differential two-form ? is introduced. Variation is performed over “umbilical surfaces“ instead of system histories. It provides correct Newton-Lagrange equations of motion. The quantization is inspired by the Feynman path integral approach. The quintessence is to rearrange it into an “umbilical world-sheet“ functional integral in accordance with the proposed variational principle. In the case of potential-generated forces, the new approach reduces to the standard quantum mechanics. As an example, Quantum Mechanics with friction is analyzed in detail. 

  3. METHODOLOGY OF AN ASSESSMENT OF RESULTS OF INTELLECTUAL ACTIVITY

    Directory of Open Access Journals (Sweden)

    Larisa I. Egorova

    2013-01-01

    Full Text Available The methodological bases of an assessment of the results of research, development and technological works and intangible assets are given in the article. A special attention is paid to the problems of formation of fair value of such assets for clients of financial accounting. The authors compare the methods of cost measurement of accounting entities regulated by Russian Accounting Standards (RAS and International Financial Reporting Standards (IFRS. Peculiarities of detection and acknowledgement of impairment of intangible assets (loss of value are considered.

  4. STRUCTURE OF THE SPANISH SYSTEM OF SATELLITE OF COMMUNICATIONS

    Directory of Open Access Journals (Sweden)

    F. Sacristán - Romero

    2007-04-01

    Full Text Available The objectives of satellites HISPASAT are oriented towards the search to satisfy necessities derived from the transport of television and radio signals. It tries the supplying of a basic and safe support of communications for the defence and security of the national territory, the creation of an infrastructure of channels for official networks, routes of data, restoration of connections, rural telephony. Also is wanted to foment the provision of television channels for the Hispanic community in the south and center of America and the broadcasting of services of television for people in general.

  5. METHODOLOGY OF DETERMINATION OF QUALITY INDEX OF MAINTENANCE SERVICE SYSTEM OF POWER EQUIPMENT OF TRACTION SUBSTATIONS

    Directory of Open Access Journals (Sweden)

    O.O. Matusevych

    2016-03-01

    Full Text Available Purpose. The purpose of this paper is development of methodology for definition of a quality system of maintenance and repair (M and P power equipment of traction substations (TS of electrified railways operating under conditions of uncertainty based on expert information. Methodology. The basic tenets of the theory of fuzzy sets and marks, linguistic and interval estimates of experts were applied to solve this problem. Results. Analysis of the existing diversity of approaches to development of modern methods of improvement of M and P allows us to conclude that the improvement in the quality of the system is achieved by solving individual problems increase the operational reliability of power equipment of traction substations in the following main interrelated areas. There are technical, economic and organizational. The basis of the quality evaluation system is initial data and expertise developed version of the document formalized quality evaluation of electrical equipment of traction substations by experts. The choice of determining the level of Quality service system based on the marks, linguistic and interval estimates of experts, which are reflected in quantitative and / or qualitative form was done. The possible options for expert data presentation and their corresponding quantitative methods of calculating the integral index of quality improvement system maintenance and P of traction substations were described. The methodology and the method of assessing the quality of system maintenance and P of TS allows quickly respond to changing operating conditions of power equipment of traction substations, and to determine the most effective strategies for maintenance of electrical and P TS under conditions of uncertainty functioning distance electricity. Originality. The method of a systematic approach to improve the quality of the system maintenance and P of power equipment of traction substation under conditions of uncertainty based on expert

  6. Assessment of the place of tubular reabsorption of phosphorus in the diagnosis of osteopenia of prematurity

    Science.gov (United States)

    Acar, Duygu Besnili; Kavuncuoğlu, Sultan; Çetinkaya, Merih; Petmezci, Ercüment; Dursun, Mesut; Korkmaz, Orhan; Altuncu, Emel Kayrak

    2015-01-01

    Aim: In this study, we aimed to investigate the utility of tubular reabsorption of phosphorus in the diagnosis of osteopenia of prematurity in addition to biochemical markers. Materials and Method: Premature babies with a gestational age of ≤32 weeks and/or a birth weight of ≤1 500 g who were hospitalized in the neonatal intensive care unit between June 2009 and March 2011 were included in the study. These babies were evaluated at the 40th gestational week and serum calcium, phosphorus, alkaline phosphatase, urea, creatinine, urinary calcium and phosphorus levels were measured and tubular reabsorption of phosphorus was determined. The subjects who had bone graphy findings and/or an alkaline phosphatase level of >400IU/L and a phosphorus value of 499 IU were compared with the newborns who were found to have a tubular reabsorption of phosphorus of ≥%95 for the objective of evaluating the specificity and sensitivity of tubular reabsorption of phosphorus, the sensitivity, specificity, positive predictive value and negative predictive value of tubular reabsorption of phosphorus in the diagnosis of osteopenia were found to be 27%, 82%, 17% and 89%, respectively. When the osteopenic and non-osteopenic patients were compared in terms of the levels of tubular reabsorption of phosphorus, no statistically significant difference was found. Conclusions: It was thought that it was not appropriate to use tubular reabsorption of phosphorus alone in the diagnosis of osteopenia of prematurity. PMID:26078696

  7. BASES OF CONSTRUCTIVITY OF MODERN PERSONALITY

    Directory of Open Access Journals (Sweden)

    Natalya Petrovna Shatalova

    2014-11-01

    Full Text Available Formation of bases of constructibility is important process at this stage of de-velopment of our state. Personality of modern type must be capable to self-determination, competent adoption of constructive decisions and manifestation of a personal responsibility for the constructive election, personality of modern type must be capable for self-determination, competent adoption of constructive decisions and manifestation to a personal responsibility for the constructive choice. Formation of bases of constructibility in the course of education is caused by use of constructive tasks and the constructive educational environment which define innovative recep-tions and skills of influence as methods of pedagogical influence taking into account constantly changing circumstances. Extent of mastering each member of society bases of constructibility defines a spiritual condition of society, of the present and the future of our country, development of economy and culture in general.Purpose: consideration of question about development of constructive thinking and constructive skills of personality in modern constructive educational environ-ment.Methodology: formal pedagogical method, the theoretical modeling, the meth-od of participant observation.Results. In the article is give the short analysis of problem of development of personality in modern society, opened the concept of constructibility of the personali-ty and her basic components, classification constructive tasks investigated, specified preparatory steps for organization of the conditions of development of a constructibil-ity and gives a brief description of their. Article has the scientific value as contains au-thor's generalizations possessing scientific novelty and the conclusions directed on disclosure of problems of formation and development of the modern personality, considered from the point of view of the theory of democratic constructivism in edu-cation.Practical implications: pedagogical

  8. ETHNOPSYCHOLOGICAL FEATURES OF VALUABLE ORIENTATIONS OF STUDENTS

    Directory of Open Access Journals (Sweden)

    Maryam T. NOGEROVA

    2015-01-01

    Full Text Available The difficulty of studying the actual problems of modern science ‒ the value-motivational sphere of personality is the lack of a common understanding of the nature and function of value orientations. Recently, it became necessary to study the factors affecting the formation of value-motivational sphere of personality determinants of which are cultural and psychological characteristics of the individual. In this regard, relevant is the study of gender and ethno-psychological features of valuable orientations of students. The purpose of this study is to identify the characteristics of the impact of ethnicity and gender of students in their value orientation. We investigate the severity of valuable orientations of students as "process‒result," "altruism‒egoism", "work‒free", "power ‒money" and their tier structure. The influence of ethnicity and gender of students on degree and level structure abovementioned value orientations. 

  9. of polygons

    KAUST Repository

    Lu, Yanyan

    2012-08-01

    Decomposing a shape in