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Sample records for aml1-eto abrogates son

  1. KRAS (G12D Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia

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    Shanmin Zhao

    2014-01-01

    Full Text Available Background/Aims: It has been demonstrated that KRAS mutations represent about 90% of cancer-associated mutations, and that KRAS mutations play an essential role in neoplastic transformation. Cancer-associated RAS mutations occur frequently in acute myeloid leukemia (AML, suggesting a functional role for Ras in leukemogenesis. Methods: We successfully established a mouse model of human leukemia by transplanting bone marrow cells co-transfected with the K-ras (G12D mutation and AML1/ETO fusion protein. Results: Mice transplanted with AML/ETO+KRAS co-transduced cells had the highest mortality rate than mice transplanted with AML/ETO- or KRAS-transduced cells (115d vs. 150d. Upon reaching a terminal disease stage, EGFP-positive cells dominated their spleen, lymph nodes, peripheral blood and central nervous system tissue. Immunophenotyping, cytologic analyses revealed that AML/ETO+KRAS leukemias predominantly contained immature myeloid precursors (EGFP+/c-Kit+/Mac-1-/Gr-1-. Histologic analyses revealed that massive leukemic infiltrations were closely packed in dense sheets that effaced the normal architecture of spleen and thymus in mice transplanted with AML1/ETO + KRAS co-transduced cells. K-ras mRNA and protein expression were upregulated in bone marrow cells of the K-ras group and AML1/ETO + Kras group. The phosphorylation of MEK/ERK was significantly enhanced in the AML1/ETO + Kras group. The similar results of the AML1/ETO + Nras group were consistent with those reported previously. Conclusion: Co-transduction of KrasG12D and AML1/ETO induces acute monoblastic leukemia. Since expression of mutant K-ras alone was insufficient to induce leukemia, this model may be useful for investigating the multi-step leukemogenesis model of human leukemia.

  2. Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation.

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    Link, Kevin A; Lin, Shan; Shrestha, Mahesh; Bowman, Melissa; Wunderlich, Mark; Bloomfield, Clara D; Huang, Gang; Mulloy, James C

    2016-08-01

    Chromosomal translocation 8;21 is found in 40% of the FAB M2 subtype of acute myeloid leukemia (AML). The resultant in-frame fusion protein AML1-ETO (AE) acts as an initiating oncogene for leukemia development. AE immortalizes human CD34(+) cord blood cells in long-term culture. We assessed the transforming properties of the alternatively spliced AE isoform AE9a (or alternative splicing at exon 9), which is fully transforming in a murine retroviral model, in human cord blood cells. Full activity was realized only upon increased fusion protein expression. This effect was recapitulated in the AE9a murine AML model. Cotransduction of AE and AE9a resulted in a strong selective pressure for AE-expressing cells. In the context of AE, AE9a did not show selection for increased expression, affirming observations of human t(8;21) patient samples where full-length AE is the dominant protein detected. Mechanistically, AE9a showed defective transcriptional regulation of AE target genes that was partially corrected at high expression. Together, these results bring an additional perspective to our understanding of AE function and highlight the contribution of oncogene expression level in t(8;21) experimental models. PMID:27457952

  3. Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling.

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    Spirin, P V; Lebedev, T D; Orlova, N N; Gornostaeva, A S; Prokofjeva, M M; Nikitenko, N A; Dmitriev, S E; Buzdin, A A; Borisov, N M; Aliper, A M; Garazha, A V; Rubtsov, P M; Stocking, C; Prassolov, V S

    2014-11-01

    The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding for the fusion protein AML1-ETO (AE) with transcription factor activity. AE is considered to be an attractive target for treating t(8;21) leukemia. However, AE expression alone is insufficient to cause transformation, and thus the potential of such therapy remains unclear. Several genes are deregulated in AML cells, including KIT that encodes a tyrosine kinase receptor. Here, we show that AML cells transduced with short hairpin RNA vector targeting AE mRNAs have a dramatic decrease in growth rate that is caused by induction of apoptosis and deregulation of the cell cycle. A reduction in KIT mRNA levels was also observed in AE-silenced cells, but silencing KIT expression reduced cell growth but did not induce apoptosis. Transcription profiling of cells that escape cell death revealed activation of a number of signaling pathways involved in cell survival and proliferation. In particular, we find that the extracellular signal-regulated kinase 2 (ERK2; also known as mitogen-activated protein kinase 1 (MAPK1)) protein could mediate activation of 23 out of 29 (79%) of these upregulated pathways and thus may be regarded as the key player in establishing the t(8;21)-positive leukemic cells resistant to AE suppression.

  4. Biological function and cancerogenic mechanism of AML1-ETO fusion protein%融合蛋白AML1-ETO的生物学功能及致癌机制探讨

    Institute of Scientific and Technical Information of China (English)

    刘晓晓; 张波; 赵倩

    2011-01-01

    AML1 - ETO fusion protein is the product of ( 8; 21 ) translocation in M2 type acute myelocytic leukemia ( AML ). As a transcription repressor, AML1 - ETO can block the differentiation of hematopoietic cells by repressing the expression of some important hematopoiesis -related transcription factors. Recent results indicate that the fusion protein also induces the epigenetic silencing of some target genes, resulting in the delay of hematopoietic maturation.Moreover, AML1 -ETO promotes the proliferation of hematopoietic stem cells through up -regulating the expression of Jagged1 and miR - 24. Meanwhile, a panel of results in the pathogenesis of AML1 - ETO show that the expression of AML1 -ETO alone can not induce AML. The secondary events or hits like c - kit gene mutation and the AML1 - ETO9a truncation play an important role in leukemogenesis of AML1 - ETO - positive cells.%@@ AML1-ETO融合蛋白是染色体易位t(8;21)(q22;q22)的产物,见于15%的急性髓细胞性白血病(acute myelocytic leukemia, AML),在FAB(French-American-British, FAB)分型M2型白血病中的阳性率为40%-50%,其中M2b亚型中的阳性率为90%,少见于M0、M1和M4型白血病,极少见于骨髓增生异常综合征(myelodysplastic syndrome, MDS).

  5. Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21 Leukemia

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    Xianjun Yu

    2016-04-01

    Full Text Available Resistance to chemotherapy is a major challenge to improving overall survival in Acute Myeloid Leukemia (AML. Therefore, the development of innovative therapies and the identification of more novel agents for AML are urgently needed. Celastrol, a compound extracted from the Chinese herb Tripterygium wilfordii Hook, exerts anticancer activity. We investigated the effect of celastrol in the t(8;21 AML cell lines Kasumi-1 and SKNO-1. We demonstrated that inhibition of cell proliferation activated caspases and disrupted mitochondrial function. In addition, we found that celastrol downregulated the AML1-ETO fusion protein, therefore downregulating C-KIT kinases and inhibiting AKT, STAT3 and Erk1/2. These findings provide clear evidence that celastrol might provide clinical benefits to patients with t(8;21 leukemia.

  6. Activated leukemic oncogenes AML1-ETO and c-kit: role in development of acute myeloid leukemia and current approaches for their inhibition.

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    Rulina, A V; Spirin, P V; Prassolov, V S

    2010-12-01

    Acute myeloid leukemia (AML) is a malignant blood disease caused by different mutations that enhance the proliferative activity and survival of blood cells and affect their differentiation and apoptosis. The most frequent disorders in AML are translocations between chromosomes 21 and 8 leading to production of a chimeric oncogene, AML1-ETO, and hyperexpression of the receptor tyrosine kinase KIT. Mutations in these genes often occur jointly. The presence in cells of two activated oncogenes is likely to trigger their malignization. The current approaches for treatment of oncologic diseases (bone marrow transplantation, radiotherapy, and chemotherapy) have significant shortcomings, and thus many laboratories are intensively developing new approaches against leukemias. Inhibiting expression of activated leukemic oncogenes based on the principle of RNA interference seems to be a promising approach in this field.

  7. Inhibitory effect of RNAi on AML1-ETO fusion gene expression in leukemia cells%RNA干扰对急性髓系白血病AML1-ETO融合基因表达的抑制作用

    Institute of Scientific and Technical Information of China (English)

    卫菊; 李肃; 王椿; 秦尤文; 马晓霞; 谢匡成; 颜式可; 高彦荣; 蔡琦

    2008-01-01

    目的 应用RNA干扰技术抑制Kasumi-1细胞AML1-ETO融合基因的表达,研究随后出现的细胞增殖和细胞周期变化.方法 体外化学合成针对AML1-ETO融合基因的小干扰RNA(siRNA),并用电穿孔方法将AML1-ETO siRNA转染Kasumi-1细胞,以非特异性的siRNA转染细胞作阴性对照;电转带有增强型绿色荧光蛋白(EGFP)的载体,流式细胞术检测其绿色荧光以确定电转效率;荧光染料实时定量PCR及Western blot检测AML1-ETO siRNA的抑制效应;并应用CCK-8实验法检测细胞增殖率;采用碘化丙锭(PI)法测定细胞周期DNA含量.结果 电转增强EGFP的转染效率可达44.5%;电转AML1-ETO siRNA可以有效抑制AML1-ETO融合基因在mRNA和蛋白水平的表达;电转AML1-ETO siRNA 72 h后细胞增殖率[(47.90±0.02)%]低于对照组[(66.90±0.08)%](P<0.05);PI染色显示AML1-ETO siRNA转染细胞72 h后,G1期细胞比例为38.3%,对照组为31.6%,而处于G2/M期细胞分别为1.8%和2.4%.结论 化学合成的特异性siRNA能抑制AML1-ETO融合基因的表达,siRNA介导的AML1-ETo融合蛋白表达减少阻滞Kasnmi-1细胞在G1期,进而抑制细胞增殖.%Objective By inhibiting AML1-ETO fusion gene expression in Kasumi-I cells with RNAi, to investigate the changes in cell proliferation and cell cycle. Methods The small interference RNAs (siRNAs) specifically targeting the AML1-ETO fusion gene were synthesized in vitro and transfected into Ka-sumi-1 cells by electroporation, the non-specific siRNAs transfected cells were taken as control. EGFP plas-mid was transfected into Kasumi-1 cell and the transfection efficiency was detected by FCM. Inhibitory effect of siRNAs were detected by real-time RT-PCR and Western blots. Cell proliferation was measured by CCK-8 assay. DNA content was detected by PI assay. Results The transfection efficiency was 44.5%. The AML1-ETO specific siRNAs inhibited AML1-ETO expression at both mRNA and protein levels. The cell proliferation rate in si

  8. Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2.

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    Ahmad, Firoz; Kokate, Prajakta; Chheda, Pratiksha; Dalvi, Rupa; Das, Bibhu Ranjan; Mandava, Swarna

    2008-01-15

    Acute myeloid leukemia (AML) is a malignant neoplasm of hematopoietic stem cells characterized by an abnormal proliferation of myeloid precursors, a reduced rate of apoptosis, and an arrest in cellular differentiation. The present report deals with the results of hematologic, immunophenotypic, cytogenetic, fluorescence in situ hybridization (FISH), and molecular analyses of a 53-year-old female patient diagnosed with AML-M2. Cytogenetic and FISH analysis revealed a complex translocation involving three chromosomes showing t(1;8;21)(p35;q22;q22). The observation of breakpoints at 8q22 and 21q22 suggests a rearrangement of the ETO and AML1 genes, respectively. Using a dual-color FISH test with ETO and AML1 probes, an AML1/ETO fusion signal on the derivative 1p35 instead of der(8) was demonstrated. To the best of our knowledge, this is the first report about the relocation of the AML1/ETO fusion gene to the 1p35 rather than der(8), suggesting the presence of a novel variant of t(8;21)(q22;q22) in the observed patient. PMID:18206543

  9. 实时定量荧光反转录-聚合酶链反应检测急性白血病AML1/ETO融合基因%Real-time RT-PCR for detection and quantification of AML1/ETO leukemia fusion gene

    Institute of Scientific and Technical Information of China (English)

    李斌; 喻镁佳; 梁洋; 李晓进; 胡杰; 陈琪; 李惠民

    2009-01-01

    Objective To set up real-time quantitative RT-PCR technique and measure leukemia fusion gene transcripts in patients with AML of FAB-M_2 subtype,and also to investigate the positive rate in patients and the relationship between the AMLI/ETO mRNA levels and the response rate after chemical therapy.Methods The plasmid containing the AMLI/ETO fusion gene sequences were constructed from myeloid cell lines Kasumi-1 (expressing AML1/ETO)to establish the standard curves,A TaqMan based realtime quantitative RT-PCR was performed to measure aberrant fusion gene transcripts in 45 samples of peripheral blood(PB) or bone marrow (BM) from 25 newly diagnosed patients with AML-M_2.All these 25 patients were diagnosed by the FCM(flow cytometry)and bone marrow molecular cytogenetics,and received the induce remission therapy with MA (Mitoxantrone+Ara-C).Results As a result,the AML1/ETO fusion gene transcripts were detected in 7(28%)out of 25 AML-M_2 patients (the ratios of AML1/ETO/ABL vary from 0.01 to 19.2),in which 5 patients were found t(8;21)(q22;q22).The transcript level of AML1/ETO fusion gene varied from the clinical situation of patients.These 7 patients with AML1/ETO fusion gene got complete remission(CR) after the first MA therapy,and the fusion gene reduced by 3 log in AML1/ETO/ABL.Only 11 patients got CR in 18 patients without AML1/ETO fusion gene.By following up these 7 patients with AML1/ ETO fusion gene kept persistent CR for 6 months.Conclusion It was concluded that real-time quantitative PCR is a reliable,innovative and promising technology with high sensitivity and speciality.It has potential clinical value for diagnosis,tumor typing,treatment selection,measuring the tumor load,monitoring fusion gene expression level and evaluating therapeutic strategy.It is worthy to apply in the clinical practice.%目的 建立实时定量荧光反转录-聚合酶链反应(RQ RT-PCR)的方法并用来检测急性髓系白血病(AML)-M_2:患者中 AML1/ETO融合基因的拷贝

  10. Monitoring AML1-ETO mRNA levels by real-time quantitative RT-PCR in t (8; 21) acute myeloid leukemia patients after hematopoietic stem cell transplantation%实时定量RT-PCR方法监测急性髓系白血病患者造血干细胞移植后AML1-ETO融合基因mRNA水平的临床意义

    Institute of Scientific and Technical Information of China (English)

    王志东; 秦亚溱; 刘艳荣; 许兰平; 刘代红; 刘开彦; 黄晓军

    2008-01-01

    目的 评价实时定量RT-PCR(Q-PCR)方法监测AML1-ETO(+)急性髓系白血病(AML)患者异基因造血干细胞移植(allo-HSCT)后AML1-ETO mRNA水平的表达及其临床意义.方法 采用基于TagMan探针的Q-PCR技术检测17例AML1-ETO(+)AML患者allo-HSCT后不同时间骨髓标本AML1-ETO mRNA的表达.AML1-ETO mRNA水平以内参基因abl进行归一化.采用荧光原位杂交(FISH)法评估HSCT后是否达到细胞遗传学完全缓解(CCyR).结果 Q-PCR实验可重复敏感度为5个拷贝.在16例CCyR患者中,1例死于移植物抗宿主病(GVHD),1例死于感染,其余14例中位随访时间为268(70~811)d,HSCT后1个月(+1月)AML1-ETO中位水平0(0~0.740),+2月为0.026(0~2.900),+3月为0.039(0~3.300).移植时间超过12个月的5例患者中,中位随访685(385~811)d,4例仍呈AML1-ETO阳性,中位值0.078(0.003~0.120).1例复发患者+1月为0,+2月为9.800,+3月为5.600,+110 d血液学复发,AML1-ETO mRNA为390.000,+382 d死亡.结论 1年内AML1-ETO持续低水平阳性不一定预示复发;对AML1-ETO(+)AML患者HSCT后定期动态监测AML1-ETO水平十分必要.%Objective To evaluate the value of real time quantitative RT-PCR(Q-PCR) for monitoring AML1-ETO mRNA levels in AMLI-ETO(+) acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods Quantification of AMLI-ETO (+) mRNA was performed serially on bone marrow samples from 17 patients with AML1-ETO (+) AML after HSCT. Q-PCR used the TagMan probe system. The AML1-ETO mRNA level was normalized by control gene abl. Cytogenetic response was evaluated by fluorescent in situ hybridization (FISH). Results The reproducible sensitivity of Q-PCR was 5 copies. Out of 16 patients who achieved sustained complete cytogenetic response (CCyR), one each died of graft-versus-host disease and infection. The median AML1-ETO mRNA levels in the rest of 14 CCyR patients were 0 (0 - 0.740), 0. 026 (0 - 2.900), 0.039 (0 - 3.300) at

  11. Chromatin accessibility, p300, and histone acetylation define PML-RARalpha and AML1-ETO binding sites in acute myeloid leukemia.

    NARCIS (Netherlands)

    Saeed, S.; Logie, C.; Francoijs, K.J.; Frige, G.; Romanenghi, M.; Nielsen, F.G.G.; Raats, L.; Shahhoseini, M.; Huynen, M.A.; Altucci, L.; Minucci, S.; Martens, J.H.; Stunnenberg, H.G.

    2012-01-01

    Chromatin accessibility plays a key role in regulating cell type specific gene expression during hematopoiesis but has also been suggested to be aberrantly regulated during leukemogenesis. To understand the leukemogenic chromatin signature, we analyzed acute promyelocytic leukemia, a subtype of leuk

  12. Amyloid precursor protein cooperates with c-KIT mutation/overexpression to regulate cell apoptosis in AML1-ETO-positive leukemia via the PI3K/AKT signaling pathway.

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    Yu, Guopan; Yin, Changxin; Jiang, Ling; Zheng, Zhongxin; Wang, Zhixiang; Wang, Chunli; Zhou, Hongsheng; Jiang, Xuejie; Liu, Qifa; Meng, Fanyi

    2016-09-01

    It has been reported that amyloid precursor protein (APP) promotes cell proliferation and metastasis in various types of solid cancers. In our previous study, we showed that APP is highly expressed and regulates leukemia cell migration in AML1‑ETO-positive (AE) leukemia. Whether APP is involved in the regulation of AE leukemia cell proliferation or apoptosis is unclear. In the present study we focused on the correlation of APP with c-KIT mutation/overexpression and cell proliferation and apoptosis in AE leukemia. APP and c-KIT expression detected by quantitative real-time (qPCR) method, and c-KIT mutations screened using PCR in bone marrow cells from 65 patients with AE leukemia before their first chemotherapy, were simultaneously assessed. Furthermore, the Kasumi-1 cell line was chosen as the cell model, and the APP gene was knocked down using siRNA technology. The correlation of cell cycle distribution and apoptosis and c-Kit expression with APP expression levels, as well as the regulation of the PI3K/AKT signaling pathway by APP were analyzed in the Kasumi-1 cell line. The results showed that peripheral white blood cell counts (P=0.008) and bone marrow cellularity (P=0.031), but not bone marrow blasts, were correlated with APP expression. Moreover, the patients with APP high expression had a significantly higher incidence of c-KIT mutations (Ptype and negative control cells, cell apoptosis, both early (P0.05). Moreover, the knockdown of APP markedly decreased c-KIT expression at both the transcription (as evidenced by qPCR analysis) and translation (as confirmed by CD117 assay and western blot analysis) levels, as well as p-AKT and its downstream targets including NF-κB, p53 and Bcl-2. In conclusion, APP may cooperate with c-KIT mutation/overexpression in the regulation of cell apoptosis but not proliferation in AE leukemia via the PI3K/AKT signaling pathway. PMID:27460334

  13. "Abrogation of Rulings” Methodology: A Critique

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    Gasser Auda

    2004-01-01

    Surveying the subject of abrogation (naskh) in the Qur’ān, ḥādīth and Islamic literature, it is clear that most abrogation cases were introduced after the Prophetic era in order to interpret certain Qur’ānic verses and Prophetic narrations (aḥādīth) that some scholars perceived as “conflicting.” Two striking examples are “The Verse of the Sword” (āyat al-saif) and “The Verse of the Barrier” (āyat al-ḥijāb). The Qur’ānic verses and aḥādīth,...

  14. Son: Part One

    Directory of Open Access Journals (Sweden)

    Jennifer Higgie

    2004-08-01

    Full Text Available It is 1842. Two Englishman set out on a Grand Tour of Europe and the Middle East. One is a young, gifted artist; the other a Gentleman. By the time they return to England, the artist has become a devotee of the Egyptian god Osiris. One night, after dining together in a small inn in Cobham, he violently murders his beloved father, believing him to be an imposter. Why? Son is a novel inspired by the life of Richard Dadd, one of the greatest Victorian painters and inmate of Bethlem Hospital - more commonly known as Bedlam. Part Two of Son will be published in Portal vol. 2, no. 1, January 2005.

  15. Son: Part Two

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    Jennifer Higgie

    2005-03-01

    Full Text Available It is 1842. Two Englishman set out on a Grand Tour of Europe and the Middle East. One is a young, gifted artist; the other a Gentleman. By the time they return to England, the artist has become a devotee of the Egyptian god Osiris. One night, after dining together in a small inn in Cobham, he violently murders his beloved father, believing him to be an imposter. Why? Son is a novel inspired by the life of Richard Dadd, one of the greatest Victorian painters and inmate of Bethlem Hospital - more commonly known as Bedlam. Part one of Son was published in PORTAL vol. 1, no. 2, in July 2004. This is the second and concluding part of the novel.

  16. Son, Sent, and Servant

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    Truls Åkerlund

    2015-11-01

    Full Text Available This study challenges the claim that Jesus is the archetypical servant leader as described in contempo-rary leadership literature. Based on a theological reading of the Fourth Gospel, the paper suggests that, as a servant, Jesus cannot be understood apart from his mission and obedience to God. Consequently, Jesus was not primarily a servant leader but rather the Son who was sent to the world to enact the Fa-ther’s will. In this regard, the Fourth Gospel provides a unique perspective that is barely noted in the current discourse on servant leadership modelled on the example of Christ. Although certain aspects of servant leadership theory correspond to John’s portrayal of Jesus, the study concludes that other de-scriptions of him as a servant leader suffer from a one-sided and reductionist Christology. Implications of this view for Christian ministry are briefly sketched out.

  17. Nutritional abrogation of photoimmunosuppression: in vivo investigations.

    Science.gov (United States)

    Pilkington, Suzanne M; Gibbs, Neil K; Friedmann, Peter S; Rhodes, Lesley E

    2014-01-01

    Skin cancer is a major public health concern, and the primary aetiological factor in the majority of skin cancers is ultraviolet radiation (UVR) exposure. UVR not only induces potentially mutagenic DNA damage but also suppresses cell-mediated immunity (CMI), allowing cancerous cells to escape destruction and progress to tumours. A considerable proportion of an individual's annual sun exposure is obtained outside the vacation period when topical and physical measures for photoprotection are irregularly used. Certain nutrients could provide an adjunctive protective role, and evidence is accruing from experimental studies to support their use in abrogation of photoimmunosuppression. Moreover, developments in clinical research methods to evaluate impact of solar-simulated radiation on cutaneous CMI allow the immune protective potential of nutritional agents to be examined in humans in vivo. This article summarises the mediation of CMI and its suppression by UVR, evaluates the methodology for quantitative assessment in vivo, reviews the human studies reported on nutritional abrogation of photoimmunosuppression including recent randomized controlled trials and discusses the mechanisms of photoprotection by the nutrients. This includes, in addition to antioxidants, novel studies of omega-3 polyunsaturated fatty acids and nicotinamide.

  18. Nutritional abrogation of photoimmunosuppression: in vivo investigations.

    Science.gov (United States)

    Pilkington, Suzanne M; Gibbs, Neil K; Friedmann, Peter S; Rhodes, Lesley E

    2014-01-01

    Skin cancer is a major public health concern, and the primary aetiological factor in the majority of skin cancers is ultraviolet radiation (UVR) exposure. UVR not only induces potentially mutagenic DNA damage but also suppresses cell-mediated immunity (CMI), allowing cancerous cells to escape destruction and progress to tumours. A considerable proportion of an individual's annual sun exposure is obtained outside the vacation period when topical and physical measures for photoprotection are irregularly used. Certain nutrients could provide an adjunctive protective role, and evidence is accruing from experimental studies to support their use in abrogation of photoimmunosuppression. Moreover, developments in clinical research methods to evaluate impact of solar-simulated radiation on cutaneous CMI allow the immune protective potential of nutritional agents to be examined in humans in vivo. This article summarises the mediation of CMI and its suppression by UVR, evaluates the methodology for quantitative assessment in vivo, reviews the human studies reported on nutritional abrogation of photoimmunosuppression including recent randomized controlled trials and discusses the mechanisms of photoprotection by the nutrients. This includes, in addition to antioxidants, novel studies of omega-3 polyunsaturated fatty acids and nicotinamide. PMID:24283330

  19. Achalasia in father and son.

    Science.gov (United States)

    Mackler, D; Schneider, R

    1978-11-01

    Achalasia has not been previously reported in father and son. A man, age 38, and his father, age 66, presented two years apart with symptoms of dysphagia and aspiration. The diagnosis of achalasia was made on the basis of x-ray and endoscopic findings and on esophageal motility studies performed on the father. Both responded well to pneumatic dilatation and have been asymptomatic for 24 months and 6 months, respectively. These cases again suggest a genetic basis for achalasia.

  20. Are we ready to abrogate compulsory vaccinations for children?

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    Martinelli, Domenico; Tafuri, Silvio; Fortunato, Francesca; Cozza, Vanessa; Germinario, Cinzia A; Prato, Rosa

    2015-01-01

    In Italy, vaccination against diphtheria, tetanus, polio and hepatitis B is compulsory for infants countrywide, except in Veneto region where since 2007 Health Authorities have experimented the suspension of mandatory vaccination. In light of the recent discussion on the potential abrogation in other regions, we explored the opinion of family pediatricians who play a crucial role in promoting immunization programmes in Italy. In November 2009, we interviewed by phone the family pediatricians working in Puglia region using a standardised, ad hoc and piloted questionnaire. Of the 596 contacted, 502 (84.2%) completed the questionnaire (54% female, median age = 52 y). Among the respondents, 72 (14.3%) would agree on the hypothesis of abrogation. This judgment was associated with having a good opinion on the level of awareness of the importance of vaccinations in the general public (OR = 6.6; 95% CI: 3.6-12.1) and having the perception of adequate organization of Vaccination Services in supporting the abrogation (OR = 3.6; 95% CI: 1.7-5.9). Family pediatricians appeared really sceptical about the abrogation of compulsory vaccination that could be hypothesized only increasing public awareness, communication skills and capability of Vaccination Services personnel in offering vaccinations.

  1. Policy-based SON management demonstrator

    NARCIS (Netherlands)

    Lohmuller, S.; Eisenblatter, A.; Frenzel, C.; Gotz, D.; Hahn, S.; Kurner, T.; Litjens, R.; Lobinger, A.; Sas, B.; Schmelz, L.C.; Turke, U.

    2015-01-01

    A Self-Organising Network (SON) represents an approach where the optimisation of a mobile radio network is automated through a set of independently operating SON functions. These SON functions, however, require to be configured in order to allow for an optimised network performance with respect to t

  2. Son huasteco e identidad regional

    Directory of Open Access Journals (Sweden)

    Rosa María Bonilla Burgos

    2013-01-01

    Full Text Available La población de la región Huasteca es partícipe de manifestaciones musicales en diferentes ámbitos, lo cual permite reconocer que entre todos los géneros utilizados destaca el son huasteco y su correspondiente bailable llamado huapango. Dichas expresiones musicales se impregnan de los ambientes tanto físico como social que viven constantemente. Es a través de las letras de los sones huastecos que se desarrolla el mecanismo para reflejar el mundo natural que perciben, y los acontecimientos que les suceden, cobrando una importancia que deriva en una identificación que trasciende. Conciben su entorno y lo refieren con sentido de pertenencia-apropiación, que les permite recrear su vida y fundirse en una identificación cultural a la que se le llamará "identidad regional". La relevancia de considerar una expresión musical de estas características radica en que se preserva y enriquece constantemente unificando un área de México que no necesariamente corresponde a límites políticos establecidos en las diferentes etapas históricas.

  3. Antibody-mediated neutralization of virus is abrogated by mycoplasma.

    OpenAIRE

    Dickson, C; Elkington, J; Hales, A.; Weiss, R.

    1980-01-01

    The ability of a mouse mammary tumor cell line to abrogate antibody neutralization of vesicular stomatitis virus was shown to be due to the presence of mycoplasma. The mycoplasma was isolated from the cell line and typed as Mycoplasma orale. Colonies of this mycoplasma were used to deliberately infect cell cultures which then gained the capacity to reactivate antibody-neutralized virus. The extent of the reactivation depended on the source of neutralizing antiserum. Other species of mycoplasm...

  4. Should attractive males have more sons?

    NARCIS (Netherlands)

    Fawcett, T.W.; Kuijper, A.L.W.; Pen, I.R.; Weissing, F.J.

    2007-01-01

    It is often argued that females with attractive partners should produce more sons because these sons will inherit their father's attractiveness. Numerous field and laboratory studies have addressed this hypothesis, with inconsistent results, but there is surprisingly little theoretical work on the t

  5. On the Themes of Sons and Lovers

    Institute of Scientific and Technical Information of China (English)

    路颖

    2015-01-01

    The current research attempts to explore the main themes of Lawrence's masterpiece Sons and Lovers from five the following aspects:Man/woman Love, the maturation of an artist, class conflict, Industrial life Vs. nature and Opposite forces: light and dark. It is great hope that this paper will make a small contribution to assist anyone who appreciates Sons and Lovers.

  6. Father-son incest: underreported psychiatric problem?

    Science.gov (United States)

    Dixon, K N; Arnold, L E; Calestro, K

    1978-07-01

    Six families are described in which 10 sons were involved incestuously with a natural father (N=4) or step-father (N=2). Father-son incest as a part of the spectrum of child abuse appears to be a more frequent clinical entity than was thought previously. PMID:665796

  7. Preference for sons: past and present.

    Science.gov (United States)

    Li, D

    1997-10-01

    This brief article discusses the present and past preference for sons in China. The preference for sons is rooted in feudal views that men are superior to women. Preference for sons dates back to the Warring States Period, in about 500 B.C. Clan brotherhoods of men have existed for centuries. Historical records mention the practice of female infanticide. Patriarchal families believed that women were economically dependent on men and thus became their subjects. Daughters married, lived in their husband's home, and did not carry the responsibility of caring for their own parents. Couples with only daughters would seek a son-in-law to support them in old age. Rural families with no sons were looked down upon. Sons were expected to carry on the family lineage, increase the reputation of the family, and protect the family's interests. The lack of sons was a sign of humiliation and a curse. The founding of the People's Republic of China brought changes to son preference. The government attempted to increase women's status. In rural areas, women were given equal access to the land. Job opportunities were created for women during the industrialization drive. The Chinese government encouraged the repudiation of the negative impacts of the doctrines of Confucius and Mencius. Efforts were made to give men and women equal pay for equal work. Legislation was passed prohibiting arranged marriage, polygyny, and early marriage. A side effect of fertility decline is the renewed preference for sons. In Huangyan and Haining in Zhejiang, a developed province, the sex ratio at birth is normal. Sexual division of labor reinforces son preference.

  8. Hematopoietic System

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    13.1 Leukocyte and leukocyte function2007252 Expression of AML1/ETO9a isoform in acute myeloid leukemia-M2 subtype. MIAO Yuqing(苗雨青),et al. The 1st Affili Hosp, Soochow Univ, Jiangsu Hematol Instit, Suzhou 215006. Chin J Hematol 2007;28(1):27-29. Objective To investigate the expression of AML1/ETO9a isoform in the acute myeloid leukemia (AML)-M2 patients. Methods Expressions of AML1/ETO fusion gene and AML1/ETO9a isoform were detected by using reverse transcriptase-polymerase chain reaction (RT-PCR) in leukemia patients, MDS patients, leukemia cell lines and healthy subjects. Karyotype was studied by R-banding technique. Result In 30 newly diagnosed AML-M2 patients, 15 were found to express AML1/ETO9a isoform, while the rest including 20 AML-M2CR, 18 other subtypes of AML, 5 chronic myelogenous leukemia(CML), 3 myelodys-plastic syndromes (MDS), 3 leukemia cell lines (NB4, KG-1, K562) and 5 healthy subjects were AML1/ETO9a negative. Among the 15 AML/ETO9a isoform expressing cases, 13 were demonstrated t(8;21) translocation and AML1/ETO expression. Conclusion lsoform AML1/ETO9a related with AML/M2, may promote the development of leukemia in combination with the AML1/ETO fusion gene.

  9. Satisfied Working Mothers and Their Preschool Sons.

    Science.gov (United States)

    Henggeler, Scott W.; Borduin, Charles M.

    1981-01-01

    Studied the effects of maternal employment on mother-child relations and children's psychosocial functioning. Mother-son pairs (N=28) were divided into maternal working versus maternal nonworking groups. Groups were observed at home and in a laboratory. Results indicated no significant main effects or interaction effects for maternal working…

  10. "Mama's Boy; Preacher's Son": A Memoir

    Science.gov (United States)

    Whitlock, Reta Ugena

    2010-01-01

    "Mama's Boy; Preacher's Son" is Kevin Jennings's autobiographical account of growing up gay in the Southern United States. In his memoir, Jennings shares formative experiences relating to his impoverished childhood and his career as teacher and social activist. His rich description of the influence of family relationships on his personal and…

  11. Curcumin and folic acid abrogated methotrexate induced vascular endothelial dysfunction.

    Science.gov (United States)

    Sankrityayan, Himanshu; Majumdar, Anuradha S

    2016-01-01

    Methotrexate, an antifolate drug widely used in rheumatoid arthritis, psoriasis, and cancer, is known to cause vascular endothelial dysfunction by causing hyperhomocysteinemia, direct injury to endothelium or by increasing the oxidative stress (raising levels of 7,8-dihydrobiopterin). Curcumin is a naturally occurring polyphenol with strong antioxidant and anti-inflammatory action and therapeutic spectra similar to that of methotrexate. This study was performed to evaluate the effects of curcumin on methotrexate induced vascular endothelial dysfunction and also compare its effect with that produced by folic acid (0.072 μg·g(-1)·day(-1), p.o., 2 weeks) per se and in combination. Male Wistar rats were exposed to methotrexate (0.35 mg·kg(-1)·day(-1), i.p.) for 2 weeks to induce endothelial dysfunction. Methotrexate exposure led to shedding of endothelium, decreased vascular reactivity, increased oxidative stress, decreased serum nitrite levels, and increase in aortic collagen deposition. Curcumin (200 mg·kg(-1)·day(-1) and 400 mg·kg(-1)·day(-1), p.o.) for 4 weeks prevented the increase in oxidative stress, decrease in serum nitrite, aortic collagen deposition, and also vascular reactivity. The effects were comparable with those produced by folic acid therapy. The study shows that curcumin, when concomitantly administered with methotrexate, abrogated its vascular side effects by preventing an increase in oxidative stress and abating any reduction in physiological nitric oxide levels. PMID:26571019

  12. Curcumin and folic acid abrogated methotrexate induced vascular endothelial dysfunction.

    Science.gov (United States)

    Sankrityayan, Himanshu; Majumdar, Anuradha S

    2016-01-01

    Methotrexate, an antifolate drug widely used in rheumatoid arthritis, psoriasis, and cancer, is known to cause vascular endothelial dysfunction by causing hyperhomocysteinemia, direct injury to endothelium or by increasing the oxidative stress (raising levels of 7,8-dihydrobiopterin). Curcumin is a naturally occurring polyphenol with strong antioxidant and anti-inflammatory action and therapeutic spectra similar to that of methotrexate. This study was performed to evaluate the effects of curcumin on methotrexate induced vascular endothelial dysfunction and also compare its effect with that produced by folic acid (0.072 μg·g(-1)·day(-1), p.o., 2 weeks) per se and in combination. Male Wistar rats were exposed to methotrexate (0.35 mg·kg(-1)·day(-1), i.p.) for 2 weeks to induce endothelial dysfunction. Methotrexate exposure led to shedding of endothelium, decreased vascular reactivity, increased oxidative stress, decreased serum nitrite levels, and increase in aortic collagen deposition. Curcumin (200 mg·kg(-1)·day(-1) and 400 mg·kg(-1)·day(-1), p.o.) for 4 weeks prevented the increase in oxidative stress, decrease in serum nitrite, aortic collagen deposition, and also vascular reactivity. The effects were comparable with those produced by folic acid therapy. The study shows that curcumin, when concomitantly administered with methotrexate, abrogated its vascular side effects by preventing an increase in oxidative stress and abating any reduction in physiological nitric oxide levels.

  13. Paradox of Denials in All My Sons

    Institute of Scientific and Technical Information of China (English)

    雷慧慧

    2014-01-01

    Arthur Miller, who was one of the greatest American playwrights of the 20th century. In All My Sons, different sorts of denials lead to the family’s collapse and Keller’s death. Paradoxically, the very denial that is designed to protect him from prose-cution and incarceration is followed by a chain of events that lead to Keller’s own self-imprisonment and self-imposed execu-tion. Denial also exists in the history of some countries, such as Germany, Japan and America and so on. My paper aims to ex-plore the paradox of denial both in our history and in literature works. My paper will demonstrate that denial has some negative effects both on the outer-world and the inner-world through thorough analysis on the characters in All My Sons.

  14. Epithelial inactivation of Yy1 abrogates lung branching morphogenesis.

    Science.gov (United States)

    Boucherat, Olivier; Landry-Truchon, Kim; Bérubé-Simard, Félix-Antoine; Houde, Nicolas; Beuret, Laurent; Lezmi, Guillaume; Foulkes, William D; Delacourt, Christophe; Charron, Jean; Jeannotte, Lucie

    2015-09-01

    Yin Yang 1 (YY1) is a multifunctional zinc-finger-containing transcription factor that plays crucial roles in numerous biological processes by selectively activating or repressing transcription, depending upon promoter contextual differences and specific protein interactions. In mice, Yy1 null mutants die early in gestation whereas Yy1 hypomorphs die at birth from lung defects. We studied how the epithelial-specific inactivation of Yy1 impacts on lung development. The Yy1 mutation in lung epithelium resulted in neonatal death due to respiratory failure. It impaired tracheal cartilage formation, altered cell differentiation, abrogated lung branching and caused airway dilation similar to that seen in human congenital cystic lung diseases. The cystic lung phenotype in Yy1 mutants can be partly explained by the reduced expression of Shh, a transcriptional target of YY1, in lung endoderm, and the subsequent derepression of mesenchymal Fgf10 expression. Accordingly, SHH supplementation partially rescued the lung phenotype in vitro. Analysis of human lung tissues revealed decreased YY1 expression in children with pleuropulmonary blastoma (PPB), a rare pediatric lung tumor arising during fetal development and associated with DICER1 mutations. No evidence for a potential genetic interplay between murine Dicer and Yy1 genes during lung morphogenesis was observed. However, the cystic lung phenotype resulting from the epithelial inactivation of Dicer function mimics the Yy1 lung malformations with similar changes in Shh and Fgf10 expression. Together, our data demonstrate the crucial requirement for YY1 in lung morphogenesis and identify Yy1 mutant mice as a potential model for studying the genetic basis of PPB. PMID:26329601

  15. Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21 Acute Myeloid Leukemia

    Directory of Open Access Journals (Sweden)

    Sai Huang

    2016-01-01

    Conclusions: Our study identified EYA4 gene as targets for AML1-ETO and indicated it as a novel tumor suppressor gene. In addition, we provided evidence that EYA4 gene might be a novel therapeutic target and a potential candidate for treating AML1-ETO+ t (8;21 AML.

  16. ?Cuales son las amenazas o peligros volcanicos?

    Science.gov (United States)

    Myers, Bobbie; Brantley, Steven R.; Stauffer, Peter; Hendley, James W.

    2000-01-01

    Los volcanes son capaces de producir numerosos peligros geologicos e hidrologicos. Los cientificos del Servicio Geologico de los EE. UU. (USGS, por sus siglas en ingles) y de otras instituciones alrededor del mundo estan estudiando los peligros de muchos de los centenares de volcanes activos y potencialmente activos del mundo. Estos cientificos vigilan muy de cerca la actividad de algunos de los volcanes mas peligrosos, por lo que estan preparados para alertar a las autoridades y/o a la poblacion en caso de que aumente sustancialmente la probabilidad de que ocurra una erupcion u otro evento peligroso.

  17. L'astronomie et son histoire

    CERN Document Server

    Roy, Jean-René

    1982-01-01

    Le livre de Jean-René Roy nous présente une vaste synthèse des connaissances présentes en astronomie. Le grand mérite du livre est de dérouler son sujet en parallèle avec une histoire de l'astronomie. Le côté historique est ici beaucoup plus qu'un luxe. Il redonne leurs dimensions vraies aux réponses qu'apporte l'astronomie. Pour bien sentir la nature d'une étape franchie, il faut aussi avoir vécu la situation telle qu'elle se présentait avant. Et les fiches personnelles incluses dans le livre ont l'intérêt de nous rapprocher encore plus du "" feu de l'action "". Écrit dans un style direct et

  18. Lo que son mujeres en los escenarios

    Directory of Open Access Journals (Sweden)

    González Cañal, Rafael

    2007-06-01

    Full Text Available In this article I review the publishing and stage trajectory of one of Rojas Zorrilla’s most significant plays: Lo que son mujeres. As well as collecting a list of the different editions, I emphasize the 1822 version by the Mexican Manuel Eduardo de Gorostiza, which started a new renaissance period for this play on stage. I also analyze the 1899 one-act version by Emilio Bobadilla. Finally, I include all the different productions between the 17th and the 19th centuries, and address the little interest aroused in the 20th century–suffice to say that it has not been staged even during these early years of the 21st century when the centenary of Rojas Zorrilla is being celebrated.En este artículo se hace un repaso detallado de la fortuna editorial y escénica de una de las obras más significativas de Rojas Zorrilla: Lo que son mujeres. Aparte de recoger las diferentes ediciones de la misma, se hace hincapié en la refundición del mexicano Manuel Eduardo de Gorostiza, estrenada en 1822, que abrió un período de cierta recuperación de este texto dramático en los escenarios. Se analiza también la refundición que llevó a cabo en un solo acto Emilio Bobadilla en 1899. Finalmente, se registran todas las representaciones conocidas de la obra desde el siglo XVII hasta el siglo XIX y se constata el poco interés que ha despertado en los escenarios del siglo XX. Incluso en los últimos años, en los que los montajes de obras de Rojas comienzan a ser más frecuentes, esta obra no ha sido todavía llevada a escena.

  19. Sons fricativos surdos Voiceless fricatives sounds

    Directory of Open Access Journals (Sweden)

    Carla Aparecida Cielo

    2008-01-01

    Full Text Available TEMA: características dos sons fricativos surdos. OBJETIVO: propor uma revisão da literatura pertinente às características acústicas, fonéticas e fonológicas dos fonemas fricativos surdos que integram o sistema fonológico do Português. Além disso, são descritas suas aplicações na terapia vocal. CONCLUSÕES: os fricativos são fonemas agudos, abrangendo de 2500 a 8000Hz; são plenamente adquiridos até os 3:7 anos de idade; o /s/ que também é o mais afetado em casos de frênulo lingual curto; a omissão do /s/ é uma das ocorrências mais freqüentes na alfabetização; sendo que, no desvio fonológico e na fissura lábio-palatina, freqüentemente ocorre comprometimento de toda a classe de fricativos. Na avaliação de voz, os fricativos são mencionados com as medidas de TMF e relação s/z, bem como seu uso como sons de apoio na fonoterapia.BACKGROUND: characteristics of voiceless fricative sounds PURPOSE: to review the literature related to acoustic, phonetics and phonological characteristics of voiceless fricative sounds that are part of the phonological system of the Portuguese Language. Furthermore, it describes the use of these sounds in voice therapy. CONCLUSIONS: fricatives are acute phonemes comprised between 2500 and 8000 Hz; they are fully acquired up to the age of 3:7 years; the /s/, which is the most affected in cases of short lingual frenum; omission of the /s/ is one of the most frequent occurrences during literacy education; and in the phonological deviation and labial-palatine fissure the entire class of fricatives is frequently affected. In voice assessment, fricative sounds are mentioned as TMF measurements and s/z relationship, and their use as support sounds in speech therapy.

  20. Mate-sampling costs and sexy sons.

    Science.gov (United States)

    Kokko, H; Booksmythe, I; Jennions, M D

    2015-01-01

    Costly female mating preferences for purely Fisherian male traits (i.e. sexual ornaments that are genetically uncorrelated with inherent viability) are not expected to persist at equilibrium. The indirect benefit of producing 'sexy sons' (Fisher process) disappears: in some models, the male trait becomes fixed; in others, a range of male trait values persist, but a larger trait confers no net fitness advantage because it lowers survival. Insufficient indirect selection to counter the direct cost of producing fewer offspring means that preferences are lost. The only well-cited exception assumes biased mutation on male traits. The above findings generally assume constant direct selection against female preferences (i.e. fixed costs). We show that if mate-sampling costs are instead derived based on an explicit account of how females acquire mates, an initially costly mating preference can coevolve with a male trait so that both persist in the presence or absence of biased mutation. Our models predict that empirically detecting selection at equilibrium will be difficult, even if selection was responsible for the location of the current equilibrium. In general, it appears useful to integrate mate sampling theory with models of genetic consequences of mating preferences: being explicit about the process by which individuals select mates can alter equilibria. PMID:25399634

  1. Having a Son Promotes Clean Cooking Fuel Use in Urban India: Women's Status and Son Preference

    OpenAIRE

    Avinash Kishore; Dean Spears

    2014-01-01

    Urban Indian households with a male first child are approximately 2 percentage points more likely to use clean cooking fuel than comparable households with a female first child. Given Indian son preference, there are at least two mechanisms by which child sex could affect fuel choice: by improving the intrahousehold status of women, who bear more of the costs of traditional fuels, or by presenting an opportunity to invest in children's health, in the context of a preference for healthier boys...

  2. The culture of referendum in Albania: Technical and theoritecal reflections on the abrogative referendum

    OpenAIRE

    Valbona Pajo Bala

    2014-01-01

    The aim of this paper is to analyse the Albanian constitutional and legal framework on referenda, in general, focusing special attention to the abrogative referenda of a law or part thereof. Given the absence of any concrete case of an abrogative referenda held in Albania, which does not creates very much room for discussion in that regard, the paper, through a comparative approach on the referenda culture in other european states, aims at offering to the reader a more complete view on the me...

  3. Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01.

    Science.gov (United States)

    On, Kin Fan; Chen, Yue; Ma, Hoi Tang; Chow, Jeremy P H; Poon, Randy Y C

    2011-05-01

    Genotoxic stress such as ionizing radiation halts entry into mitosis by activation of the G(2) DNA damage checkpoint. The CHK1 inhibitor 7-hydroxystaurosporine (UCN-01) can bypass the checkpoint and induce unscheduled mitosis in irradiated cells. Precisely, how cells behave following checkpoint abrogation remains to be defined. In this study, we tracked the fates of individual cells after checkpoint abrogation, focusing in particular on whether they undergo mitotic catastrophe. Surprisingly, while a subset of UCN-01-treated cells were immediately eliminated during the first mitosis after checkpoint abrogation, about half remained viable and progressed into G(1). Both the delay of mitotic entry and the level of mitotic catastrophe were dependent on the dose of radiation. Although the level of mitotic catastrophe was specific for different cell lines, it could be promoted by extending the mitosis. In supporting this idea, weakening of the spindle-assembly checkpoint, by either depleting MAD2 or overexpressing the MAD2-binding protein p31(comet), suppressed mitotic catastrophe. Conversely, delaying of mitotic exit by depleting either p31(comet) or CDC20 tipped the balance toward mitotic catastrophe. These results underscore the interplay between the level of DNA damage and the effectiveness of the spindle-assembly checkpoint in determining whether checkpoint-abrogated cells are eliminated during mitosis.

  4. Is the distant relationship of fathers and homosexual sons related to the sons' erotic preference for male partners, or to the sons' atypical gender identity, or to both?

    Science.gov (United States)

    Freund, K; Blanchard, R

    1983-01-01

    Study 1 compared the retrospectively reported father-son relationships of four groups of adult males: (a) Gynephiles (males who erotically prefer physically mature females), (b) androphiles (who prefer physically mature males), (c) a combined group of heterosexual pedophiles and pedohebephiles (the latter being attracted to pubescent as well as prepubescent females), and (d) a combined group of homosexual pedophiles and pedohebephiles (the latter attracted to pubescent as well as prepubescent males). The gynephiles were paid volunteers; the latter three groups were patients. The androphiles, the only group among those compared known to exhibit a measurably greater degree of cross gender identity in childhood, were also the only group to report significantly poorer father-son relations. The homosexual pedo/pedohebephiles, who also prefer male partners but who exhibit typical male gender identity in childhood, did not differ in father-son relations from the gynephiles or the heterosexual pedo/pedohebephiles. Study 2 showed that, within a sample of nonpatient volunteer androphiles, those individuals who reported the greatest degree of cross gender behavior in childhood also tended to report the worst relationships with their fathers. This correlation was replicated within a sample of androphilic patients in Study 3. The consistent pattern of results obtained from these three studies suggests that the emotionally distant relationships of fathers and androphilic sons relate to the sons' atypical childhood gender identity (or observable gender role behavior) rather than to the sons' erotic preference for male partners per se.

  5. Son preference in rural China: patrilineal families and socioeconomic change.

    Science.gov (United States)

    Murphy, Rachel; Tao, Ran; Lu, Xi

    2011-01-01

    This article draws on a survey conducted in six provinces in summer 2008 to investigate the determinants of son preference in rural China. The analysis confirms the conventional wisdom that son preference is embedded within patrilineal family structures and practices. We extend our analysis by exploring specific aspects of variation within patrilineal family culture. We find that the patrilineal group (clan) composition of villages and family participation in practices such as building ancestral halls and updating genealogies significantly influence son preference. Yet even though son preference is embedded within patrilineal family culture, our analysis suggests that over time the attenuation of son preference is likely. This is because determinants associated with socioeconomic change—for instance, higher levels of education, direct exposure to official policy education materials, higher income (a proxy for rural industrialization), and agricultural mechanization—all attenuate son preference. Being younger and female are also associated with weaker son preference, and both characteristics are likely to interact with education and industrialization to further dilute son preference in the longer term. Nevertheless, our findings suggest that concerted efforts are needed to ameliorate institutional discrimination against rural people in welfare provisioning and in labor markets, and to promote multiple dimensions of gender equality, including in land rights, wage rates, and education.

  6. A Letter from a Black Mom to Her Son

    Science.gov (United States)

    Watson, Dyan

    2012-01-01

    An African American mother and teacher educator uses examples from her own childhood to describe how she hopes her child will be treated by teachers, and what she fears. In her letter to her son, the African American mom expresses how she want teachers to know her son's journey to school--metaphorically and physically. She wants them to know that…

  7. Optical spectroscopy investigation of peptides issued from the AML1-ETO–E-protein complex relevant to acute myeloid leukemia

    OpenAIRE

    Porumb, H.

    2008-01-01

    The expression of AML1-ETO, resulting from the t(8; 21) chromosomal translocation causes 15% of acute myeloid leukaemias. The NHR2 region of ETO, bearing the motif LxxLL, is involved in the oligomerisation of the AML1-ETO. “Peptide NHR2” is one of the objects of the present investigation. The TAFH region of ETO may recruit AML1-ETO to transcription activators, such as E-protein. “Peptide TAFH” is another object of the present investigation. TAFH interacts with E-protein through the AD1 domain...

  8. Causal Attributions and Parents' Acceptance of Their Homosexual Sons.

    Science.gov (United States)

    Belsky, Yael; Diamond, Gary M

    2015-01-01

    This Internet-based study examined the association between Israeli parents' attributions regarding the cause of their son's homosexuality and their level of acceptance of their homosexual son. The sample (N = 57) was recruited via Internet Web sites (gay forums and support groups). Findings suggest that more essentialist (versus constructivist) causal attributions were associated with higher levels of parental acceptance. Length of time parents knew of their son's homosexual orientation predicted the degree to which their attributions were essentialist. Implications are discussed.

  9. Causal Attributions and Parents' Acceptance of Their Homosexual Sons.

    Science.gov (United States)

    Belsky, Yael; Diamond, Gary M

    2015-01-01

    This Internet-based study examined the association between Israeli parents' attributions regarding the cause of their son's homosexuality and their level of acceptance of their homosexual son. The sample (N = 57) was recruited via Internet Web sites (gay forums and support groups). Findings suggest that more essentialist (versus constructivist) causal attributions were associated with higher levels of parental acceptance. Length of time parents knew of their son's homosexual orientation predicted the degree to which their attributions were essentialist. Implications are discussed. PMID:26177158

  10. Mother-son incest as a defence against psychosis.

    Science.gov (United States)

    Bachmann, K M; Bossi, J

    1993-09-01

    In the following, a case of mother-adult son incest is described and explained from a psychoanalytical viewpoint. Two theories are put forward: (a) Mother-son incest may occur as a defence against psychosis, and (b) the incest represents an unconscious search for triangulation, a process in which external authorities (such as, for example, a court of law) may function as surrogates for persons who have been missed in the pre-oedipal past. It is therefore possible to understand mother-son incest symbolically as an indicator of pre-oedipal needs of the son and of the mother's longing for the absent partner. The incest is, however, not only a cry for help; it is also to be regarded as an attempt to solve the problem for both people involved. Looked at in this way, new ways of understanding and new possibilities for therapy emerge.

  11. The role of son preference in reproductive behaviour in Pakistan.

    Science.gov (United States)

    Hussain, R; Fikree, F F; Berendes, H W

    2000-01-01

    The sex of surviving children is an important determinant of reproductive behaviour in South Asia in general and Pakistan in particular. This cohort study evaluates the role of the sex of children on reproductive intentions and subsequent behaviour of women in urban slums of Karachi, Pakistan. The analysis is based on two rounds of surveys conducted in 1990-91 and 1995 of a cohort of married women aged 15-49 years. The results show that pregnancies became increasingly unwanted as the number of surviving sons increased. The sex of surviving children was strongly correlated with subsequent fertility and contraceptive behaviour. However, rather than an exclusive son preference, couples strove for one or more sons and at least one surviving daughter. The policy implications of the link between overt son preference and low status of women are discussed. PMID:10812738

  12. Remarks on Psychological Analyses of Sons and Lovers

    Institute of Scientific and Technical Information of China (English)

    杨艳微

    2007-01-01

    Sons and Lovers is considered to be D.H.Lawrene's first masterpiece. Social critique and psychological exploration are two props of creative works of D.H.Lawrence. There are two points of view in literature world about the novel Sons and Lovers: One is its critical function which criticizes the destroy of capitalistic industrial civilization to human body and mind. The other is psychological analyses. The tragedy of the characters attributes to the Oedipus complex.

  13. The discovery and exploration of Hang Son Doong

    Energy Technology Data Exchange (ETDEWEB)

    Limbert, H.; Limbert, D.; Hieu, N.; Phai, V. V.; Kinh Bac, D.; Phuong, T. H.; Granger, D.

    2016-08-01

    Hang Son Doong is located in the Phong Nha Ke Bang Limestone Massif in Quang Binh Province, Central Vietnam. Cave exploration by British cavers has been continuous in this area since 1990. Hang Son Doong is part of the Phong Nha Cave system which runs from the southern end of the National Park near the Lao border to the final resurgence at Phong Nha Cave. (Author)

  14. Abrogation of the Transactivation Activity of p53 by BCCIP Down-regulation*

    OpenAIRE

    Meng, Xiangbing; Yue, Jingyin; Liu, Zhihe; Shen, Zhiyuan

    2006-01-01

    The tumor suppression function of p53 is mostly conferred by its transactivation activity, which is inactivated by p53 mutations in ~50% of human cancers. In cancers harboring wild type p53, the p53 transactivation activity may be compromised by other mechanisms. Identifying the mechanisms by which wild type p53 transactivation activity can be abrogated may provide insights into the molecular etiology of cancers harboring wild type p53. In this report, we show that BCCIP, a BRCA2 and CDKN1A-i...

  15. Vpliv sončnih elektrarn na napetostni profil

    OpenAIRE

    Zupanc, Karel

    2013-01-01

    Z vključevanjem sončnih fotonapetostnih elektrarn v elektroenergetski sistem lahko vplivamo na smer pretoka moči in posledično napetostni profil vzdolž nizkonapetostnega omrežja. Cilj magistrskega dela je bil na podlagi meritev in analitičnega orodja prepoznati ter ovrednotiti eventualne negativne vplive na napetostni profil. Ugotovili smo, da sončne fotonapetostne elektrarne na obravnavanem področju vplivajo na napetostni profil, vendar v mejah dovoljenega. To pa ne pomeni, da negativne...

  16. Observations of a Father: My Son Has Spina Bifida.

    Science.gov (United States)

    Remmel, Carl L.

    1982-01-01

    The author reviews his experiences as the father of a child with spina bifida, a congenital problem in which the spine is not completely enclosed. He recounts his feelings upon first finding out about the condition and his son's subsequent surgeries and crises. (CL)

  17. ¿Qué son los "massive open online courses"?

    OpenAIRE

    Luján Mora, Sergio

    2012-01-01

    Conferencia "¿Qué son los "massive open online courses"?" impartida en las Segundas Jornadas de la Facultad de Ingeniería y Ciencias Agropecuarias en la Universidad de las Américas (Quito, Ecuador) el 28 de mayo de 2012.

  18. African American Single Mothers Raising Sons: Implications for Family Therapy

    Science.gov (United States)

    Gantt, Ann L.; Greif, Geoffrey L.

    2009-01-01

    Being raised by a single mother is one factor that has been suggested as contributing to the plight of African American males. Yet few studies have focused specifically on African American single mothers' experiences with raising sons. This qualitative study explored the following questions: (1) What are the experiences of African American single…

  19. Conflicts between Spirit and Body in Sons and Lovers

    Institute of Scientific and Technical Information of China (English)

    赵佳

    2009-01-01

    The purpose of this paper is to analyze the conflicts between spirit and body that exist among characters in Sons and Lovers. By stating the complicated relationships of Mr. and Mrs. Morel, two sons and their mother, and the protagonist Paul and two women, Miriam and Clara, spirit and body collides and conflicts emerge from time to time. Conflicts between blood ties and lovers' affairs, moral principles and incest, and chastity and lust are reflected on char-acters, especially Paul in the novel. It concludes that Mrs. Morel's influence on Paul's spirit and thought is great. Her spiritual domination on Paul is the main factor for these conflicts. Her death at the end of the story will be a brand-new start of Paul's life.

  20. An ecological reading of the sons and lovers

    Institute of Scientific and Technical Information of China (English)

    徐萌萌

    2012-01-01

    1 .Introduction D.H. Lawrence is one of the greatest writers in the English lit- erature history. The author makes a textual analysis of the novel-- Sons and Lovers, David Herbert Lawrence's third novel Which is also his first masterpiece. The novel is recognized as the pioneer work among English novels and now has become one of the most widespread readings. As his representative, sons and lovers is a work filled with ecological elements, which discovered lots of social and psychological problems through the description of the character Paul's growing. Under the backgrounds of the author's own growing experiences and Industry Revolution, the natural circumstances has been ruined, the sick relationship in the worker's family,

  1. HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding

    Institute of Scientific and Technical Information of China (English)

    Guo-Zhong Gong; Yong-Fang Jiang; Yan He; Li-Ying Lai; Ying-Hua Zhu; Xian-Shi Su

    2004-01-01

    AIM: To evaluate the inhibition effect of HCV NS5A on p53 transactivation on p21 promoter and explore its possible mechanism for influencing p53 function.METHODS: p53 function of transactivation on p21 promoter was studied with a luciferase reporter system in which the luciferase gene is driven by p21 promoter, and the p53-DNA binding ability was observed with the use of electrophoretic mobility-shift assay (EMSA). Lipofectin mediated p53 or HCV NS5A expression vectors were used to transfect hepatoma cell lines to observe whether HCV NS5A could abrogate the binding ability of p53 to its specific DNA sequence and p53 transactivation on p21 promoter.Western blot experiment was used for detection of HCV NS5A and p53 proteins expression.RESULTS: Relative luciferase activity driven by p21 promoter increased significantly in the presence of endogenous p53 protein. Compared to the control group, exogenous p53 protein also stimulated p21 promoter driven luciferase gene expression in a dose-dependent way. HCV NS5A protein gradually inhibited both endogenous and exogenous p53 transactivation on p21 promoter with increase of the dose of HCV NS5A expression plasmid. By the experiment of EMSA, we could find p53 binding to its specific DNA sequence and, when co-transfected with increased dose of HCV NS5A expression vector, the p53 binding affinity to its DNA gradually decreased and finally disappeared. Between the Huh 7 cells transfected with p53 expression vector alone or co-transfected with HCV NS5A expression vector, there was no difference in the p53 protein expression.CONCLUSION: HCV NS5A inhibits p53 transactivation on p21 promoter through abrogating p53 binding affinity to its specific DNA sequence. It does not affect p53 protein expression.

  2. Son preference in Indian families: absolute versus relative wealth effects.

    Science.gov (United States)

    Gaudin, Sylvestre

    2011-02-01

    The desire for male children is prevalent in India, where son preference has been shown to affect fertility behavior and intrahousehold allocation of resources. Economic theory predicts less gender discrimination in wealthier households, but demographers and sociologists have argued that wealth can exacerbate bias in the Indian context. I argue that these apparently conflicting theories can be reconciled and simultaneously tested if one considers that they are based on two different notions of wealth: one related to resource constraints (absolute wealth), and the other to notions of local status (relative wealth). Using cross-sectional data from the 1998-1999 and 2005-2006 National Family and Health Surveys, I construct measures of absolute and relative wealth by using principal components analysis. A series of statistical models of son preference is estimated by using multilevel methods. Results consistently show that higher absolute wealth is strongly associated with lower son preference, and the effect is 20%-40% stronger when the household's community-specific wealth score is included in the regression. Coefficients on relative wealth are positive and significant although lower in magnitude. Results are robust to using different samples, alternative groupings of households in local areas, different estimation methods, and alternative dependent variables.

  3. Like Father, Like Son? Intergenerational Educational Mobility in India.

    Science.gov (United States)

    Azam, Mehtabul; Bhatt, Vipul

    2015-12-01

    Using the nationally representative India Human Development Survey (IHDS), we create a unique son-father matched data set that is representative of the entire adult male population (aged 20-65) in India. We use these data to document the evolution of intergenerational transmission of educational attainment in India over time, among different castes and states for the birth cohorts of 1940-1985. We find that educational persistence, as measured by the regression coefficient of father's education as a predictor of son's education, has declined over time. This implies that increases in average educational attainment are driven primarily by increases among children of less-educated fathers. However, we do not find such a declining trend in the correlation between educational attainment of sons and fathers, which is another commonly used measure of persistence. To understand the source of such a discrepancy between the two measures of educational persistence, we decompose the intergenerational correlation and find that although persistence has declined at the lower end of the fathers' educational distribution, it has increased at the top end of that distribution.

  4. Son preference in Indian families: absolute versus relative wealth effects.

    Science.gov (United States)

    Gaudin, Sylvestre

    2011-02-01

    The desire for male children is prevalent in India, where son preference has been shown to affect fertility behavior and intrahousehold allocation of resources. Economic theory predicts less gender discrimination in wealthier households, but demographers and sociologists have argued that wealth can exacerbate bias in the Indian context. I argue that these apparently conflicting theories can be reconciled and simultaneously tested if one considers that they are based on two different notions of wealth: one related to resource constraints (absolute wealth), and the other to notions of local status (relative wealth). Using cross-sectional data from the 1998-1999 and 2005-2006 National Family and Health Surveys, I construct measures of absolute and relative wealth by using principal components analysis. A series of statistical models of son preference is estimated by using multilevel methods. Results consistently show that higher absolute wealth is strongly associated with lower son preference, and the effect is 20%-40% stronger when the household's community-specific wealth score is included in the regression. Coefficients on relative wealth are positive and significant although lower in magnitude. Results are robust to using different samples, alternative groupings of households in local areas, different estimation methods, and alternative dependent variables. PMID:21302027

  5. Male-mediated infertility in sons of building painters and gardeners

    DEFF Research Database (Denmark)

    Ramlau-Hansen, Cecilia; Stoltenberg, Christian Ditlev G; Hougaard, K S;

    2012-01-01

    To investigate whether sons of gardeners and building painters have increased risk of infertility in comparison with sons of bricklayers, carpenters and electricians.......To investigate whether sons of gardeners and building painters have increased risk of infertility in comparison with sons of bricklayers, carpenters and electricians....

  6. [Bladder cancer at an early age in father and son].

    Science.gov (United States)

    Ovsiannikov, D; Stöhr, R; Hartmann, A; Böttrich, R; Hengstler, J G; Golka, K

    2011-12-01

    Bladder cancer may be caused by external factors like tobacco smoking, but may also be familial. We report on a father and son who developed this tumour at the ages of 45 and 35. Testing various genetic markers including the mismatch repair proteins MLH1, MSH2 and MSH6, whose loss is associated with a higher risk for hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome), did not point to a familial disease. Thus the heavy smoking habits of the two patients must be considered as causal.

  7. Son-Yamamoto relation and Holographic RG flows

    CERN Document Server

    Dubinkin, O; Milekhin, A

    2014-01-01

    Motivated by the Son-Yamamoto (SY) relation which connects the three point and two-point correlators we consider the holographic RG flows in the bottom-up approach to holographic QCD via the Hamilton-Jacobi (HJ) equation with respect to the radial coordinate . It is shown that the SY relation is diagonal with respect to the RG flow in the 5d YM-CS model while the RG equation acquires the inhomogeneous term in the model with the additional scalar field which encodes the chiral condensate.

  8. Cryptorchidism and hypospadias in sons of gardeners and farmers

    DEFF Research Database (Denmark)

    Weidner, I S; Møller, H; Jensen, Tina Kold;

    1998-01-01

    Cryptorchidism and hypospadias have been related to prenatal estrogen exposure in animal models. Some chemicals used in farming and gardening have been shown to possess estrogenic and other hormone-disrupting effects. Earlier studies have indicated increased risks of urogenital malformations...... in the sons of pesticide appliers. In the present study, parental occupation in the farming and gardening industry among 6,177 cases of cryptorchidism, 1,345 cases of hypospadias, and 23,273 controls, born live from 1983 to 1992 in Denmark, was investigated in a register-based case-control study...

  9. Herpesvirus telomerase RNA (vTR with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis.

    Directory of Open Access Journals (Sweden)

    Benedikt B Kaufer

    2011-10-01

    Full Text Available Telomerase reverse transcriptase (TERT and telomerase RNA (TR represent the enzymatically active components of telomerase. In the complex, TR provides the template for the addition of telomeric repeats to telomeres, a protective structure at the end of linear chromosomes. Human TR with a mutation in the template region has been previously shown to inhibit proliferation of cancer cells in vitro. In this report, we examined the effects of a mutation in the template of a virus encoded TR (vTR on herpesvirus-induced tumorigenesis in vivo. For this purpose, we used the oncogenic avian herpesvirus Marek's disease virus (MDV as a natural virus-host model for lymphomagenesis. We generated recombinant MDV in which the vTR template sequence was mutated from AATCCCAATC to ATATATATAT (vAU5 by two-step Red-mediated mutagenesis. Recombinant viruses harboring the template mutation replicated with kinetics comparable to parental and revertant viruses in vitro. However, mutation of the vTR template sequence completely abrogated virus-induced tumor formation in vivo, although the virus was able to undergo low-level lytic replication. To confirm that the absence of tumors was dependent on the presence of mutant vTR in the telomerase complex, a second mutation was introduced in vAU5 that targeted the P6.1 stem loop, a conserved region essential for vTR-TERT interaction. Absence of vTR-AU5 from the telomerase complex restored virus-induced lymphoma formation. To test if the attenuated vAU5 could be used as an effective vaccine against MDV, we performed vaccination-challenge studies and determined that vaccination with vAU5 completely protected chickens from lethal challenge with highly virulent MDV. Taken together, our results demonstrate 1 that mutation of the vTR template sequence can completely abrogate virus-induced tumorigenesis, likely by the inhibition of cancer cell proliferation, and 2 that this strategy could be used to generate novel vaccine candidates

  10. Tetrandrine: A Potent Abrogator of G2 Checkpoint Function in Tumor Cells and Its Mechanism

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective To assess the ability of tetrandrine (Tet) to enhance the sensitivity to irradiation and its mechanism in cell lines of human breast cancer p53-mutant MCF-7/ADR, p53-wild-type MCF-7 and human colon carcinoma p53-mutant HT-29 as well as in C26 colorectal carcinoma-bearing BALB/c mice. Methods MCF-7/ADR, HT-29 and MCF-7 cells were exposed to irradiation in the absence or presence of tetrandrine. The effect of Tet on the cytotoxicity of X-irradiation in these three cells was determined and the effect of tetrandrine on cell cycle arrest induced by irradiation in its absence or presence was studied by flow cytometry, Moreover, mitotic index measurement determined mitosis of cells to enter mitosis. Western blotting was employed to detect cyclin B1 and Cdc2 proteins in extracts from irradiated or non-irradiated cells of MCF-7/ADR, HT-29 and MCF-7 treated with tetrandrine at various concentrations. Tumor growth delay assay was conducted to determine the radio-sensitization of tetrandrine in vivo. Results Clonogenic assay showed that tetrandrine markedly enhanced the lethal effect of X-rays on p53-mutant MCF-7/ADR and HT-29 cells and the sensitization enhancement ratio (SER) of tetrandrine was 1.51 and 1.63, but its SER was only 1.1 in p53-wt MCF-7 cells. Irradiated p53-mutant MCF-7/ADR and HT-29 cells were only arrested in G2/M phase while MCF-7 cells were arrested in G1 and G2/M phases. Radiation-induced G2 phase arrests were abrogated by tetrandrine in a concentration-dependent manner in MCF-7/ADR and HT-29 cells,whereas redistribution within MCF-7 cell cycle changed slightly. The proportion of cells in M phase increased from 1.3% to 14.7% in MCF-7/ADR cells, and from 1.5% to 13.2% in HT-29 cells, but 2.4% to 7.1% in MCF-7 cells. Furthermore, the levels of cyclin B 1 and Cdc2 expression decreased after X-irradiation in MCF-7/ADR and HT-29 cells, and the mitotic index was also lower. Tet could reverse the decrease and induce the irradiated cells to enter mitosis

  11. Son preference, sex selection, and kinship in Vietnam.

    Science.gov (United States)

    Guilmoto, Christophe Z

    2012-01-01

    This article examines the recent rise in the sex ratio at birth in Vietnam and relates its emergence to kinship systems and ethnic composition using 2009 census micro-data. Presentation of the main socioeconomic and ethnic differentials in birth masculinity is followed by a review of the three intermediate factors leading to increases in the sex ratio at birth: prenatal technology, declining fertility, and gender bias. An indirect measurement of fertility behavior is used to demonstrate the close association between levels of the sex ratio at birth and the intensity of son preference. Data on household composition indicate that Vietnam is characterized by the co-existence of kinship patterns typical of East and Southeast Asia. Son preference in Vietnam is found to be related to the prevalence of more traditional patrilineal systems. The article concludes by considering the implications of the cultural dimensions of prenatal sex selection for policy responses and for the likely future change in the sex ratio at birth.

  12. miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice.

    Directory of Open Access Journals (Sweden)

    Cyrielle Clapé

    Full Text Available BACKGROUND: Micro RNAs are small, non-coding, single-stranded RNAs that negatively regulate gene expression at the post-transcriptional level. Since miR-143 was found to be down-regulated in prostate cancer cells, we wanted to analyze its expression in human prostate cancer, and test the ability of miR-43 to arrest prostate cancer cell growth in vitro and in vivo. RESULTS: Expression of miR-143 was analyzed in human prostate cancers by quantitative PCR, and by in situ hybridization. miR-143 was introduced in cancer cells in vivo by electroporation. Bioinformatics analysis and luciferase-based assays were used to determine miR-143 targets. We show in this study that miR-143 levels are inversely correlated with advanced stages of prostate cancer. Rescue of miR-143 expression in cancer cells results in the arrest of cell proliferation and the abrogation of tumor growth in mice. Furthermore, we show that the effects of miR-143 are mediated, at least in part by the inhibition of extracellular signal-regulated kinase-5 (ERK5 activity. We show here that ERK5 is a miR-143 target in prostate cancer. CONCLUSIONS: miR-143 is as a new target for prostate cancer treatment.

  13. Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.

    Science.gov (United States)

    Chow, Bryna S Man; Kocan, Martina; Bosnyak, Sanja; Sarwar, Mohsin; Wigg, Belinda; Jones, Emma S; Widdop, Robert E; Summers, Roger J; Bathgate, Ross A D; Hewitson, Tim D; Samuel, Chrishan S

    2014-07-01

    Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic therapy; however, its mechanism of action is poorly understood. Recent studies have shown that relaxin disrupts the profibrotic actions of transforming growth factor-β1 (TGF-β1) by its cognate receptor, relaxin family peptide receptor 1 (RXFP1), extracellular signal-regulated kinase phosphorylation, and a neuronal nitric oxide synthase-dependent pathway to abrogate Smad2 phosphorylation. Since angiotensin II also inhibits TGF-β1 activity through its AT2 receptor (AT2R), we investigated the extent to which relaxin interacts with the AT2R. The effects of the AT2R antagonist, PD123319, on relaxin activity were examined in primary rat kidney myofibroblasts, and in kidney tissue from relaxin-treated male wild-type and AT2R-knockout mice subjected to unilateral ureteric obstruction. Relaxin's antifibrotic actions were significantly blocked by PD123319 in vitro and in vivo, or when relaxin was administered to AT2R-knockout mice. While heterodimer complexes were formed between RXFP1 and AT2Rs independent of ligand binding, relaxin did not directly bind to AT2Rs but signaled through RXFP1-AT2R heterodimers to induce its antifibrotic actions. These findings highlight a hitherto unrecognized interaction that may be targeted to control fibrosis progression. PMID:24429402

  14. JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth

    Directory of Open Access Journals (Sweden)

    Malabika Sen

    2015-03-01

    Full Text Available Aberrant activation of the Janus kinase (JAK/signal transducer and activator of transcription (STAT 3 has been implicated in cell proliferation and survival of many cancers including head and neck squamous cell carcinoma (HNSCC. AZD1480, an orally active pharmacologic inhibitor of JAK1/JAK2, has been tested in several cancer models. In the present study, the in vitro and in vivo effects of AZD1480 were evaluated in HNSCC preclinical models to test the potential use of JAK kinase inhibition for HNSCC therapy. AZD1480 treatment decreased HNSCC proliferation in HNSCC cell lines with half maximal effective concentration (EC50 values ranging from 0.9 to 4 μM in conjunction with reduction of pSTAT3Tyr705 expression. In vivo antitumor efficacy of AZD1480 was demonstrated in patient-derived xenograft (PDX models derived from two independent HNSCC tumors. Oral administration of AZD1480 reduced tumor growth in conjunction with decreased pSTAT3Tyr705 expression that was observed in both PDX models. These findings suggest that the JAK1/2 inhibitors abrogate STAT3 signaling and may be effective in HNSCC treatment approaches.

  15. Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion.

    Science.gov (United States)

    Cossu, Irene; Bottoni, Gianluca; Loi, Monica; Emionite, Laura; Bartolini, Alice; Di Paolo, Daniela; Brignole, Chiara; Piaggio, Francesca; Perri, Patrizia; Sacchi, Angelina; Curnis, Flavio; Gagliani, Maria Cristina; Bruno, Silvia; Marini, Cecilia; Gori, Alessandro; Longhi, Renato; Murgia, Daniele; Sementa, Angela Rita; Cilli, Michele; Tacchetti, Carlo; Corti, Angelo; Sambuceti, Gianmario; Marchiò, Serena; Ponzoni, Mirco; Pastorino, Fabio

    2015-11-01

    Selective tumor targeting is expected to enhance drug delivery and to decrease toxicity, resulting in an improved therapeutic index. We have recently identified the HSYWLRS peptide sequence as a specific ligand for aggressive neuroblastoma, a childhood tumor mostly refractory to current therapies. Here we validated the specific binding of HSYWLRS to neuroblastoma cell suspensions obtained either from cell lines, animal models, or Schwannian-stroma poor, stage IV neuroblastoma patients. Binding of the biotinylated peptide and of HSYWLRS-functionalized fluorescent quantum dots or liposomal nanoparticles was dose-dependent and inhibited by an excess of free peptide. In animal models obtained by the orthotopic implant of either MYCN-amplified or MYCN single copy human neuroblastoma cell lines, treatment with HSYWLRS-targeted, doxorubicin-loaded Stealth Liposomes increased tumor vascular permeability and perfusion, enhancing tumor penetration of the drug. This formulation proved to exert a potent antitumor efficacy, as evaluated by bioluminescence imaging and micro-PET, leading to (i) delay of tumor growth paralleled by decreased tumor glucose consumption, and (ii) abrogation of metastatic spreading, accompanied by absence of systemic toxicity and significant increase in the animal life span. Our findings are functional to the design of targeted nanocarriers with potentiated therapeutic efficacy towards the clinical translation.

  16. Niacinamide abrogates the organ dysfunction and acute lung injury caused by endotoxin.

    Science.gov (United States)

    Kao, Shang-Jyh; Liu, Demeral David; Su, Chain-Fa; Chen, Hsing I

    2007-09-01

    Poly (ADP-ribose) synthabse (PARS) or polymerase (PARP) is a cytotoxic enzyme causing cellular damage. Niacinamide inhibits PARS or PARP. The present experiment tests the effects of niacinamide (NCA) on organ dysfunction and acute lung injury (ALI) following lipopolysaccharide (LPS). LPS was administered to anesthetized rats and to isolated rat lungs. In anesthetized rats, LPS caused systemic hypotension and increased biochemical factors, nitrate/nitrite (NOx), methyl guanidine (MG), tumor necrosis factoralpha (TNFalpha), and interleukin-1beta (IL-1beta). In isolated lungs, LPS increased lung weight (LW) to body weight ratio, LW gain, protein and dye tracer leakage, and capillary permeability. The insult also increased NOx, MG, TNFalpha, and IL-1beta in lung perfusate, while decreased adenosine triphosphate (ATP) content with an increase in PARP activity in lung tissue. Pathological examination revealed pulmonary edema with inflammatory cell infiltration. These changes were abrogated by posttreatment (30 min after LPS) with NCA. Following LPS, the inducible NO synthase (iNOS) mRNA expression was increased. NCA reduced the iNOS expression. Niacinamide exerts protective effects on the organ dysfunction and ALI caused by endotoxin. The mechanisms may be mediated through the inhibition on the PARP activity, iNOS expression and the subsequent suppression of NO, free radicals, and proinflammatory cytokines with restoration of ATP.

  17. Beclin1-induced autophagy abrogates radioresistance of lung cancer cells by suppressing osteopontin

    International Nuclear Information System (INIS)

    Osteopontin (OPN) serves as an indicator of resistance to radiotherapy. However, the role of OPN in the development of acquired radioresistance in human lung cancer cells has not yet been fully elucidated. Therefore, the potential importance of OPN as a marker of lung cancer with a potential significant role in the development of radioresistance against repeated radiotherapy has prompted us to define the pathways by which OPN regulates lung cancer cell growth. In addition, autophagy has been reported to play a key role in the radiosensitization of cancer cells. Here, we report that increased OPN expression through induction of nuclear p53 following irradiation was inhibited by exogenous beclin-1 (BECN1). Our results clearly show that BECN1 gene expression led to induction of autophagy and inhibition of cancer cell growth and angiogenesis. Our results suggest that the induction of autophagy abrogated the radioresistance of the cancer cells. Interestingly, we showed that knockdown of OPN by lentivirus-mediated shRNA induced the autophagy of human lung cancer cell. Taken together, these results suggest that OPN and BECN1 can be molecular targets for overcoming radioresistance by controlling autophagy. (author)

  18. Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction.

    Science.gov (United States)

    Huang, Yan; Wang, Dandan; Wang, Xin; Zhang, Yijie; Liu, Tao; Chen, Yuting; Tang, Yanhong; Wang, Teng; Hu, Dan; Huang, Congxin

    2016-01-01

    CC chemokine receptor 9 (CCR9), which is a unique receptor for CC chemokine ligand (CCL25), is mainly expressed on lymphocytes, dendritic cells (DCs) and monocytes/macrophages. CCR9 mediates the chemotaxis of inflammatory cells and participates in the pathological progression of inflammatory diseases. However, the role of CCR9 in the pathological process of myocardial infarction (MI) remains unexplored; inflammation plays a key role in this process. Here, we used CCR9 knockout mice to determine the functional significance of CCR9 in regulating post-MI cardiac remodeling and its underlying mechanism. MI was induced by surgical ligation of the left anterior descending coronary artery in CCR9 knockout mice and their CCR9+/+ littermates. Our results showed that the CCR9 expression levels were up-regulated in the hearts of the MI mice. Abrogation of CCR9 improved the post-MI survival rate and left ventricular (LV) dysfunction and decreased the infarct size. In addition, the CCR9 knockout mice exhibited attenuated inflammation, apoptosis, structural and electrical remodeling compared with the CCR9+/+ MI mice. Mechanistically, CCR9 mainly regulated the pathological response by interfering with the NF-κB and MAPK signaling pathways. In conclusion, the data reveal that CCR9 serves as a novel modulator of pathological progression following MI through NF-κB and MAPK signaling.

  19. Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer.

    Science.gov (United States)

    Wang, Weimin; Kryczek, Ilona; Dostál, Lubomír; Lin, Heng; Tan, Lijun; Zhao, Lili; Lu, Fujia; Wei, Shuang; Maj, Tomasz; Peng, Dongjun; He, Gong; Vatan, Linda; Szeliga, Wojciech; Kuick, Rork; Kotarski, Jan; Tarkowski, Rafał; Dou, Yali; Rattan, Ramandeep; Munkarah, Adnan; Liu, J Rebecca; Zou, Weiping

    2016-05-19

    Effector T cells and fibroblasts are major components in the tumor microenvironment. The means through which these cellular interactions affect chemoresistance is unclear. Here, we show that fibroblasts diminish nuclear accumulation of platinum in ovarian cancer cells, resulting in resistance to platinum-based chemotherapy. We demonstrate that glutathione and cysteine released by fibroblasts contribute to this resistance. CD8(+) T cells abolish the resistance by altering glutathione and cystine metabolism in fibroblasts. CD8(+) T-cell-derived interferon (IFN)γ controls fibroblast glutathione and cysteine through upregulation of gamma-glutamyltransferases and transcriptional repression of system xc(-) cystine and glutamate antiporter via the JAK/STAT1 pathway. The presence of stromal fibroblasts and CD8(+) T cells is negatively and positively associated with ovarian cancer patient survival, respectively. Thus, our work uncovers a mode of action for effector T cells: they abrogate stromal-mediated chemoresistance. Capitalizing upon the interplay between chemotherapy and immunotherapy holds high potential for cancer treatment.

  20. Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB

    Directory of Open Access Journals (Sweden)

    Wang-Jian Zha

    2013-01-01

    Full Text Available Persistent activation of nuclear factor κB (NF-κB has been associated with the development of asthma. Galangin, the active pharmacological ingredient from Alpinia galanga, is reported to have a variety of anti-inflammatory properties in vitro via negative regulation of NF-κB. This study aimed to investigate whether galangin can abrogate ovalbumin- (OVA- induced airway inflammation by negative regulation of NF-κB. BALB/c mice sensitized and challenged with OVA developed airway hyperresponsiveness (AHR and inflammation. Galangin dose dependently inhibited OVA-induced increases in total cell counts, eosinophil counts, and interleukin-(IL- 4, IL-5, and IL-13 levels in bronchoalveolar lavage fluid, and reduced serum level of OVA-specific IgE. Galangin also attenuated AHR, reduced eosinophil infiltration and goblet cell hyperplasia, and reduced expression of inducible nitric oxide synthase and vascular cell adhesion protein-1 (VCAM-1 levels in lung tissue. Additionally, galangin blocked inhibitor of κB degradation, phosphorylation of the p65 subunit of NF-κB, and p65 nuclear translocation from lung tissues of OVA-sensitized mice. Similarly, in normal human airway smooth muscle cells, galangin blocked tumor necrosis factor-α induced p65 nuclear translocation and expression of monocyte chemoattractant protein-1, eotaxin, CXCL10, and VCAM-1. These results suggest that galangin can attenuate ovalbumin-induced airway inflammation by inhibiting the NF-κB pathway.

  1. SysSon - A Framework for Systematic Sonification Design

    Science.gov (United States)

    Vogt, Katharina; Goudarzi, Visda; Holger Rutz, Hanns

    2015-04-01

    SysSon is a research approach on introducing sonification systematically to a scientific community where it is not yet commonly used - e.g., in climate science. Thereby, both technical and socio-cultural barriers have to be met. The approach was further developed with climate scientists, who participated in contextual inquiries, usability tests and a workshop of collaborative design. Following from these extensive user tests resulted our final software framework. As frontend, a graphical user interface allows climate scientists to parametrize standard sonifications with their own data sets. Additionally, an interactive shell allows to code new sonifications for users competent in sound design. The framework is a standalone desktop application, available as open source (for details see http://sysson.kug.ac.at/) and works with data in NetCDF format.

  2. ¿Otras palabras, otra mirada, son otros?

    OpenAIRE

    Giglio, Martín

    2011-01-01

    ¿Integrar o Incluir? O mejor dicho: ¿Qué hacemos con este otro? En este relato trabajamos sobre las conceptualizaciones teóricas de términos muy usados en los terrenos de la discapacidad, como lo son: integración e inclusión y diversidad. Su uso y entendimiento histórico y las prácticas que producen. Desentrañamos la mirada del docente y la pretensión cultural de la sociedad, como determinante en la construcción de un cuerpo normal. Y proponemos un cambio en la mirada de la construcción de...

  3. Transgenerational effects of nutrition are different for sons and daughters.

    Science.gov (United States)

    Zizzari, Z V; van Straalen, N M; Ellers, J

    2016-07-01

    Food shortage is an important selective factor shaping animal life-history trajectories. Yet, despite its role, many aspects of the interaction between parental and offspring food environments remain unclear. In this study, we measured developmental plasticity in response to food availability over two generations and tested the relative contribution of paternal and maternal food availability to the performance of offspring reared under matched and mismatched food environments. We applied a cross-generational split-brood design using the springtail Orchesella cincta, which is found in the litter layer of temperate forests. The results show adverse effects of food limitation on several life-history traits and reproductive performance of both parental sexes. Food conditions of both parents contributed to the offspring phenotypic variation, providing evidence for transgenerational effects of diet. Parental diet influenced sons' age at maturity and daughters' weight at maturity. Specifically, being born to food-restricted parents allowed offspring to alleviate the adverse effects of food limitation, without reducing their performance under well-fed conditions. Thus, parents raised on a poor diet primed their offspring for a more efficient resource use. However, a mismatch between maternal and offspring food environments generated sex-specific adverse effects: female offspring born to well-fed mothers showed a decreased flexibility to deal with low-food conditions. Notably, these maternal effects of food availability were not observed in the sons. Finally, we found that the relationship between age and size at maturity differed between males and females and showed that offspring life-history strategies in O. cincta are primed differently by the parents. PMID:27018780

  4. Chrysin, an anti-inflammatory molecule, abrogates renal dysfunction in type 2 diabetic rats

    International Nuclear Information System (INIS)

    Diabetic nepropathy (DN) is considered as the leading cause of end-stage renal disease (ESRD) worldwide, but the current available treatments are limited. Recent experimental evidences support the role of chronic microinflammation in the development of DN. Therefore, the tumor necrosis factor-alpha (TNF-α) pathway has emerged as a new therapeutic target for the treatment of DN. We investigated the nephroprotective effects of chrysin (5, 7-dihydroxyflavone) in a high fat diet/streptozotocin (HFD/STZ)-induced type 2 diabetic Wistar albino rat model. Chrysin is a potent anti-inflammatory compound that is abundantly found in plant extracts, honey and bee propolis. The treatment with chrysin for 16 weeks post induction of diabetes significantly abrogated renal dysfunction and oxidative stress. Chrysin treatment considerably reduced renal TNF-α expression and inhibited the nuclear transcription factor-kappa B (NF-kB) activation. Furthermore, chrysin treatment improved renal pathology and suppressed transforming growth factor-beta (TGF-β), fibronectin and collagen-IV protein expressions in renal tissues. Chrysin also significantly reduced the serum levels of pro-inflammatory cytokines, interleukin-1beta (IL-1β) and IL-6. Moreover, there were no appreciable differences in fasting blood glucose and serum insulin levels between the chrysin treated groups compared to the HFD/STZ-treated group. Hence, our results suggest that chrysin prevents the development of DN in HFD/STZ-induced type 2 diabetic rats through anti-inflammatory effects in the kidney by specifically targeting the TNF-α pathway. - Highlights: • Chrysin reduced renal oxidative stress and inflammation in diabetic rats. • Chrysin reduced serum levels of pro-inflammatory in diabetic rats. • Chrysin exhibited renal protective effect by suppressing the TNF-α pathway

  5. Mammalian target of rapamycin inhibitor abrogates abnormal osteoclastogenesis in neurofibromatosis type 1

    Institute of Scientific and Technical Information of China (English)

    LIU Ning; XU Ning; WEI Li-hui; CHAI Guo-lin

    2013-01-01

    Background Neurofibromatosis type 1 (NF1) is the most common genetic syndrome predisposing patients to various tumors due to dysregulation of the Ras signaling pathway.Recent research has shown NF1 patients also suffer a spectrum of bone pathologies.The pathogenesis of NF1 bone diseases is largely unknown.There is no current treatment.By Nf1 heterozygote (Nf1+/-) mice and Nf1 conditional knockout mice,we and other groups demonstrated abnormal osteoblast and osteoclast function due to dysregulation of Ras signaling.However,the specific downstream effector pathways linked to NF1 abnormal osteoblastogenesis and osteoclastogenesis have not been defined.In this study,we investigated the Ras downstream effector related with NF1 bone disease.Methods We used Nf1+/+ and Nf1+/-mice as normal and NF1 models.Bone stromal cells extracted from Nf1+/+ and Nf1+/-mice were induced osteoclasts.The osteoclast cell was stained by tartrate resistant acid phosphatase staining.The osteoclast cell number was counted and the surface area of osteoclast cells was calculated under the microscope.The mRNA of mammalian target of rapamycin (mTOR) was determined by quantitative reverse-transcription-polymerase chain reaction.The presence of ribosomal protein S6 kinase was determined by Western blotting.Results Compared with Nf1+/+ mice,Nf1+/-mice had about 20% more of osteoclast cells.These osteoclast cells werelarger in size with more nuclei.Hyperactive mTOR was detected in Nf1+/-osteoclast cells.Inhibition of mTOR signalingby rapamycin in Nf1+/-osteoclasts abrogated abnormalities in cellular size and number.Conclusion mTOR pathway inhibition may represent a viable therapy for NF1 bone diseases.

  6. Chrysin, an anti-inflammatory molecule, abrogates renal dysfunction in type 2 diabetic rats

    Energy Technology Data Exchange (ETDEWEB)

    Ahad, Amjid [Lipid Metabolism Laboratory, Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062 (India); Ganai, Ajaz Ahmad [Department of Biotechnology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062 (India); Mujeeb, Mohd [Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062 (India); Siddiqui, Waseem Ahmad, E-mail: was.sid121@gmail.com [Lipid Metabolism Laboratory, Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062 (India)

    2014-08-15

    Diabetic nepropathy (DN) is considered as the leading cause of end-stage renal disease (ESRD) worldwide, but the current available treatments are limited. Recent experimental evidences support the role of chronic microinflammation in the development of DN. Therefore, the tumor necrosis factor-alpha (TNF-α) pathway has emerged as a new therapeutic target for the treatment of DN. We investigated the nephroprotective effects of chrysin (5, 7-dihydroxyflavone) in a high fat diet/streptozotocin (HFD/STZ)-induced type 2 diabetic Wistar albino rat model. Chrysin is a potent anti-inflammatory compound that is abundantly found in plant extracts, honey and bee propolis. The treatment with chrysin for 16 weeks post induction of diabetes significantly abrogated renal dysfunction and oxidative stress. Chrysin treatment considerably reduced renal TNF-α expression and inhibited the nuclear transcription factor-kappa B (NF-kB) activation. Furthermore, chrysin treatment improved renal pathology and suppressed transforming growth factor-beta (TGF-β), fibronectin and collagen-IV protein expressions in renal tissues. Chrysin also significantly reduced the serum levels of pro-inflammatory cytokines, interleukin-1beta (IL-1β) and IL-6. Moreover, there were no appreciable differences in fasting blood glucose and serum insulin levels between the chrysin treated groups compared to the HFD/STZ-treated group. Hence, our results suggest that chrysin prevents the development of DN in HFD/STZ-induced type 2 diabetic rats through anti-inflammatory effects in the kidney by specifically targeting the TNF-α pathway. - Highlights: • Chrysin reduced renal oxidative stress and inflammation in diabetic rats. • Chrysin reduced serum levels of pro-inflammatory in diabetic rats. • Chrysin exhibited renal protective effect by suppressing the TNF-α pathway.

  7. KNK437, abrogates hypoxia-induced radioresistance by dual targeting of the AKT and HIF-1{alpha} survival pathways

    Energy Technology Data Exchange (ETDEWEB)

    Oommen, Deepu, E-mail: oommen1978@gmail.com [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast, Northern Ireland (United Kingdom); Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast, Northern Ireland (United Kingdom)

    2012-05-11

    Highlights: Black-Right-Pointing-Pointer KNK437, a benzylidene lactam compound, is a novel radiosensitizer. Black-Right-Pointing-Pointer KNK437 inhibits AKT signaling and abrogates the accumulation of HIF-1{alpha} under hypoxia. Black-Right-Pointing-Pointer KNK437 abrogates hypoxia induced resistance to radiation. -- Abstract: KNK437 is a benzylidene lactam compound known to inhibit stress-induced synthesis of heat shock proteins (HSPs). HSPs promote radioresistance and play a major role in stabilizing hypoxia inducible factor-1{alpha} (HIF-1{alpha}). HIF-1{alpha} is widely responsible for tumor resistance to radiation under hypoxic conditions. We hypothesized that KNK437 sensitizes cancer cells to radiation and overrides hypoxia-induced radioresistance via destabilizing HIF-1{alpha}. Treatment of human cancer cells MDA-MB-231 and T98G with KNK437 sensitized them to ionizing radiation (IR). Surprisingly, IR did not induce HSPs in these cell lines. As hypothesized, KNK437 abrogated the accumulation of HIF-1{alpha} in hypoxic cells. However, there was no induction of HSPs under hypoxic conditions. Moreover, the proteosome inhibitor MG132 did not restore HIF-1{alpha} levels in KNK437-treated cells. This suggested that the absence of HIF-1{alpha} in hypoxic cells was not due to the enhanced protein degradation. HIF-1{alpha} is mainly regulated at the level of post-transcription and AKT is known to modulate the translation of HIF-1{alpha} mRNA. Interestingly, pre-treatment of cells with KNK437 inhibited AKT signaling. Furthermore, down regulation of AKT by siRNA abrogated HIF-1{alpha} levels under hypoxia. Interestingly, KNK437 reduced cell survival in hypoxic conditions and inhibited hypoxia-induced resistance to radiation. Taken together, these data suggest that KNK437 is an effective radiosensitizer that targets multiple pro-survival stress response pathways.

  8. New discoveries of old SON: a link between RNA splicing and cancer.

    Science.gov (United States)

    Hickey, Christopher J; Kim, Jung-Hyun; Ahn, Eun-Young Erin

    2014-02-01

    The SON protein is a ubiquitously expressed DNA- and RNA-binding protein primarily localized to nuclear speckles. Although several early studies implicated SON in DNA-binding, tumorigenesis and apoptosis, functional significance of this protein had not been recognized until recent studies discovered SON as a novel RNA splicing co-factor. During constitutive RNA splicing, SON ensures efficient intron removal from the transcripts containing suboptimal splice sites. Importantly, SON-mediated splicing is required for proper processing of selective transcripts related to cell cycle, microtubules, centrosome maintenance, and genome stability. Moreover, SON regulates alternative splicing of RNAs from the genes involved in apoptosis and epigenetic modification. In addition to the role in RNA splicing, SON has an ability to suppress transcriptional activation at certain promoter/enhancer DNA sequences. Considering the multiple SON target genes which are directly involved in cell proliferation, genome stability and chromatin modifications, SON is an emerging player in gene regulation during cancer development and progression. Here, we summarize available information from several early studies on SON, and highlight recent discoveries describing molecular mechanisms of SON-mediated gene regulation. We propose that our future effort on better understanding of diverse SON functions would reveal novel targets for cancer therapy.

  9. ¿Las agencias son unidades administrativas especiales?

    Directory of Open Access Journals (Sweden)

    Consuelo Sarria

    2015-06-01

    Full Text Available Al plantearse como tema del artículo el de si las agencias son unidades administrativas especiales, el trabajo debe abordar dos conceptos aparentemente diferentes en cuanto al contenido y la génesis, pues de un lado se tiene conocimiento de las unidades administrativas especiales creadas con la finalidad de realizar actividades propias de un ministerio o departamento administrativo, y que, en consecuencia, siguiendo lineamientos jurisprudenciales, debían formar parte de la estructura de aquellos o estos. No obstante el reproche doctrinal referido a que a ciertas unidades administrativas se les otorgaba personería jurídica, llama la atención el cambio de criterio jurisprudencial que las avaló, y la manera en que a partir de la Constitución de 1991 se regularon unidades con o sin personería jurídica. Al abordar el tema de las agencias del Estado resulta relevante el origen anglosajón del término y la ausencia de características que las identifiquen, y la ausencia de un régimen común. Se hace especial mención a la reforma de 2011 y a cómo se crearon varias Agencias del Estado, algunas definidas como Unidades Administrativas Especiales, ante lo que cabe interrogarse sobre la correspondencia entre ambas nociones.

  10. Jean Alesi and his son Giuliano visited CERN

    CERN Multimedia

    Emma Jones

    2010-01-01

    Jean Alesi, former F1 racing driver, and his kids visited CERN on Monday 1st February 2010. The Bulletin and the Video productions team had the opportunity to meet him. The video interview is transcribed for your convenience. What attracted you to CERN, what was it that made you want to come? We talked at home with the children about places to see close to us, like CERN, where they are seeking to reproduce the origins of the world. These things are so far removed from what we ordinarily think and talk about, that they captured our imagination and made us want to come see for ourselves. We know that your son (Giuliano, 9 years) is interested in what is happening at CERN, so we'd like to ask him: how did he find out about it? Giuliano: I am very interested in the technologies used in laboratories, and the exploration of the Universe. Plus, I wanted to see some of the incredible machines. I enjoyed my visit a lot. I found out about CERN from my mother. She showed me a video that I really liked, so I wanted to...

  11. Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells

    Directory of Open Access Journals (Sweden)

    Astuti Puji

    2012-11-01

    Full Text Available Abstract Background The high cost and low level of cancer survival urge the finding of new drugs having better mechanisms. There is a high trend of patients to be “back to nature” and use natural products as an alternative way to cure cancer. The fact is that some of available anticancer drugs are originated from plants, such as taxane, vincristine, vinblastine, pacitaxel. Curcumin (diferuloylmethane, a dietary pigment present in Curcuma longa rizhome is reported to induce cell cycle arrest in some cell lines. Other study reported that genistein isolated from Glycine max seed inhibited phosphorylation of cdk1, gene involved during G2/M transition and thus could function as G2 checkpoint abrogator. The inhibition of cdk1 phosphorylation is one of alternative strategy which could selectively kill cancer cells and potentially be combined with DNA damaging agent such as curcumin. Methods T47D cell line was treated with different concentrations of curcumin and genistein, alone or in combination; added together or with interval time. Flow Cytometry and MTT assay were used to evaluate cell cycle distribution and viability, respectively. The presence of apoptotic cells was determined using acridine orange-ethidium bromide staining. Results In this study curcumin induced G2 arrest on p53 deficient T47D cells at the concentration of 10 μM. Increasing concentration up to 30 μM increased the number of cell death. Whilst genistein alone at low concentration (≤10 μM induced cell proliferation, addition of genistein (20 μM 16 h after curcumin resulted in more cell death (89%, 34% higher than that administered at the same time (56%. The combination treatment resulted in apoptotic cell death. Combining curcumin with high dose of genistein (50 μM induced necrotic cells. Conclusions Genistein increased the death of curcumin treated T47D cells. Appropriate timing of administration and concentration of genistein determine the outcome of

  12. Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells

    Science.gov (United States)

    2012-01-01

    Background The high cost and low level of cancer survival urge the finding of new drugs having better mechanisms. There is a high trend of patients to be “back to nature” and use natural products as an alternative way to cure cancer. The fact is that some of available anticancer drugs are originated from plants, such as taxane, vincristine, vinblastine, pacitaxel. Curcumin (diferuloylmethane), a dietary pigment present in Curcuma longa rizhome is reported to induce cell cycle arrest in some cell lines. Other study reported that genistein isolated from Glycine max seed inhibited phosphorylation of cdk1, gene involved during G2/M transition and thus could function as G2 checkpoint abrogator. The inhibition of cdk1 phosphorylation is one of alternative strategy which could selectively kill cancer cells and potentially be combined with DNA damaging agent such as curcumin. Methods T47D cell line was treated with different concentrations of curcumin and genistein, alone or in combination; added together or with interval time. Flow Cytometry and MTT assay were used to evaluate cell cycle distribution and viability, respectively. The presence of apoptotic cells was determined using acridine orange-ethidium bromide staining. Results In this study curcumin induced G2 arrest on p53 deficient T47D cells at the concentration of 10 μM. Increasing concentration up to 30 μM increased the number of cell death. Whilst genistein alone at low concentration (≤10 μM) induced cell proliferation, addition of genistein (20 μM) 16 h after curcumin resulted in more cell death (89%), 34% higher than that administered at the same time (56%). The combination treatment resulted in apoptotic cell death. Combining curcumin with high dose of genistein (50 μM) induced necrotic cells. Conclusions Genistein increased the death of curcumin treated T47D cells. Appropriate timing of administration and concentration of genistein determine the outcome of treatment and this method

  13. De Novo Truncating Variants in SON Cause Intellectual Disability, Congenital Malformations, and Failure to Thrive.

    Science.gov (United States)

    Tokita, Mari J; Braxton, Alicia A; Shao, Yunru; Lewis, Andrea M; Vincent, Marie; Küry, Sébastien; Besnard, Thomas; Isidor, Bertrand; Latypova, Xénia; Bézieau, Stéphane; Liu, Pengfei; Motter, Connie S; Melver, Catherine Ward; Robin, Nathaniel H; Infante, Elena M; McGuire, Marianne; El-Gharbawy, Areeg; Littlejohn, Rebecca O; McLean, Scott D; Bi, Weimin; Bacino, Carlos A; Lalani, Seema R; Scott, Daryl A; Eng, Christine M; Yang, Yaping; Schaaf, Christian P; Walkiewicz, Magdalena A

    2016-09-01

    SON is a key component of the spliceosomal complex and a critical mediator of constitutive and alternative splicing. Additionally, SON has been shown to influence cell-cycle progression, genomic integrity, and maintenance of pluripotency in stem cell populations. The clear functional relevance of SON in coordinating essential cellular processes and its presence in diverse human tissues suggests that intact SON might be crucial for normal growth and development. However, the phenotypic effects of deleterious germline variants in SON have not been clearly defined. Herein, we describe seven unrelated individuals with de novo variants in SON and propose that deleterious variants in SON are associated with a severe multisystem disorder characterized by developmental delay, persistent feeding difficulties, and congenital malformations, including brain anomalies.

  14. De Novo Truncating Variants in SON Cause Intellectual Disability, Congenital Malformations, and Failure to Thrive.

    Science.gov (United States)

    Tokita, Mari J; Braxton, Alicia A; Shao, Yunru; Lewis, Andrea M; Vincent, Marie; Küry, Sébastien; Besnard, Thomas; Isidor, Bertrand; Latypova, Xénia; Bézieau, Stéphane; Liu, Pengfei; Motter, Connie S; Melver, Catherine Ward; Robin, Nathaniel H; Infante, Elena M; McGuire, Marianne; El-Gharbawy, Areeg; Littlejohn, Rebecca O; McLean, Scott D; Bi, Weimin; Bacino, Carlos A; Lalani, Seema R; Scott, Daryl A; Eng, Christine M; Yang, Yaping; Schaaf, Christian P; Walkiewicz, Magdalena A

    2016-09-01

    SON is a key component of the spliceosomal complex and a critical mediator of constitutive and alternative splicing. Additionally, SON has been shown to influence cell-cycle progression, genomic integrity, and maintenance of pluripotency in stem cell populations. The clear functional relevance of SON in coordinating essential cellular processes and its presence in diverse human tissues suggests that intact SON might be crucial for normal growth and development. However, the phenotypic effects of deleterious germline variants in SON have not been clearly defined. Herein, we describe seven unrelated individuals with de novo variants in SON and propose that deleterious variants in SON are associated with a severe multisystem disorder characterized by developmental delay, persistent feeding difficulties, and congenital malformations, including brain anomalies. PMID:27545676

  15. On the“Oedipus Complex”in Sons and Lovers-Mother is a lover of her son

    Institute of Scientific and Technical Information of China (English)

    王瑞瑒

    2014-01-01

    Sons and Lovers is one of Lawrence’s most famous novels. It mainly concerns about the love affairs among the main character-Paul, his mother and his two girlfriends. The mother’s strange love has affected the boys for a long time, which even has made him lose the ability to love other girls. As a result, Paul gradually has the“Oedipus Complex”towards his mother, and it has influenced the whole lifetime of himself. During the competition of grasp the heart of Paul, Miriam and Clara are all the los-ers, while they both can’t drag Paul out of the influence from his mother. It is not until the death of his mother does Paul finally escape from the control of his mother. All the origins can be concluded into one thing-that is the Paul’s“Oedipus Complex”towards his mother. What is the“Oedipus Complex”, and how does it reflect in the main content? How does it influence the emotions of Paul step by step? This essay will elaborate it in detail.

  16. SysSon: A Sonification Platform for Climate Data

    Science.gov (United States)

    Visda, Goudarzi; Hanns Holger, Rutz; Katharina, Vogt

    2014-05-01

    Climate data provide a challenging working basis for sonification. Both model data and measured data are assessed in collaboration with the Wegener Center for Climate and Global Change. The multi dimensionality and multi variety of climate data has a great potential for auditory displays. Furthermore, there is consensus on global climate change and the necessity of intensified climate research today in the scientific community and general public. Sonification provides a new means to communicate scientific results and inform a wider audience. SysSon is a user centered auditory platform for climate scientists to analyze data. It gives scientists broader insights by extracting hidden patterns and features from data that is not possible using a single modal visual interface. A variety of soundscapes to chose from lessens the fatigue that comes with repeated and sustained listening to long streams of data. Initial needs assessments and user tests made the work procedures and the terminology of climate scientists clear and informed the architecture of our system. Furthermore, experiments evaluated the sound design which led to a more advanced soundscape and improvement of the auditory display. We present a novel interactive sonification tool which combines a workspace for the scientists with a development environment for sonification models. The tool runs on different operating systems and is released as open source. In the standalone desktop application, multiple data sources can be imported, navigated and manipulated either via text or a graphical interface, including traditional plotting facilities. Sound models are built from unit generator graphs which are enhanced with matrix manipulation functions. They allow us to systematically experiment with elements known from the visual domain, such as range selections, scaling, thresholding, markers and labels. The models are organized in an extensible library, from which the user can choose and parametrize. Importance is

  17. ¿Son los MOOC una alternativa de aprendizaje?

    Directory of Open Access Journals (Sweden)

    Antonio Ramón Bartolomé Pina

    2015-01-01

    Full Text Available Este trabajo reflexiona sobre los MOOC como entornos de aprendizaje. El número de cursos masivos abiertos y en línea (MOOC ha crecido exponencialmente en pocos años desde que fueron introducidos. Los MOOC son considerados una nueva forma de entornos virtuales de aprendizaje potenciados por la tecnología. Se consideran dos tipos de MOOC: unos los organizados por Siemens y Downes (cMOOC y otros los desarrollados en lugares como Stanford, con muchos estudiantes y loables objetivos (xMOOC; estos tienen también sus debilidades. Aunque han sido recibidos con altas expectativas, también han encontrado una fuerte oposición que está aumentando con el tiempo, lo que nos permite estudiar este fenómeno en profundidad. Aunque todavía hay pocas investigaciones empíricas sobre los efectos de los MOOC en el aprendizaje, este estudio trata de arrojar luz sobre el tema desde un punto de vista teórico. En primer lugar exploraremos las expectativas positivas y negativas generadas. Los MOOC pueden constituir una buena propuesta a gran escala, lo que solo es posible para unas pocas grandes instituciones. No hay estudio de mercado, ni modelo de negocio, ni investigaciones empíricas que permitan confirmar los anuncios de sus efectos positivos. Revisaremos las teorías del aprendizaje recientes y clásicas respecto a su capacidad para explicar el proceso de aprendizaje y compararemos los cursos en línea tradicionales, los xMOOC y los cMOOC en relación a su potencial para apoyar el aprendizaje y su auto-regulación.

  18. Dessiner son parcours professionnel, pour en tirer des enseignements

    Directory of Open Access Journals (Sweden)

    Pascale Corten-Gualtieri

    2011-02-01

    Full Text Available Dans le cadre de la formation continue pour des enseignants du supérieur, une activité d’expression visuelle a soutenu une posture réflexive à propos du développement professionnel de chacun. Il a été demandé aux enseignants de dessiner leur parcours professionnel en le comparant à un parcours routier. Ce dessin a ensuite servi de support aux enseignants pour dégager les leviers et les freins de leur développement professionnel, puis pour clarifier leur(s perspective(s d’évolution professionnelle. Cadrage théorique et échanges en binômes ont enrichi ce regard distancié. L’ensemble de ces activités constitue une préparation efficace et motivante à la rédaction d’un portfolio dans lequel l’enseignant analyse ses pratiques et son développement professionnels. Cet article décrit le cadre théorique et les modalités de cet ensemble d’activités ; il analyse ensuite les résultats obtenus, essentiellement à partir de l’étude du corpus de dessins réalisés par les enseignants, et d’une enquête d’évaluation réalisée auprès de ceux-ci.A recent visual creative activity carried out during a continuous education programme for teachers in higher education enhances reflective practice regarding professional development. Teachers were asked to draw their professional path as they would draw a route map. On the basis of this drawing, they were able to highlight the levers and obstacles in their professional development and then clarify their perspectives in terms of professional growth. This analysis was emphasized using a theoretical framework and exchanges in teams of two. All activities comprised an effective and stimulating preparation for writing a portfolio in which the teachers analyzed their professional practices and development. This article describes the theoretical framework and methods used during these activities; it then analyzes the results obtained based on the study of the various drawings made

  19. Like father like son? Sons of patients of European or Indian origin with coronary artery disease reflect their parents' risk factor patterns.

    OpenAIRE

    Shaukat, N.; de Bono, D P; Jones, D R

    1995-01-01

    OBJECTIVE--To investigate the extent to which risk factor patterns associated with coronary artery disease (CAD) in patients of Indian origin and in those of North European origin undergoing coronary angiography for suspected angina were reflected in their apparently healthy sons aged 15-30 years. DESIGN--Prospective study in which risk markers were measured in patients of Indian origin and in matched European patients undergoing angiography and in their sons. SETTING--Patients attending a re...

  20. Are simple tests of son preference useful? An evaluation using data from Vietnam

    OpenAIRE

    Jonathan Haughton; Dominique Haughton

    1998-01-01

    Son preference is widespread although not universal. Where it occurs it may lead to higher fertility rates. Ideally son preference should be measured in the context of a hazards or parity progression model of fertility, or a logistic model of contraceptive use. Such models require large amounts of survey data, particularly to measure the covariates. Can son preference be discerned reliably using tests which rely on more limited information? The answer is yes, based on applying eight simple te...

  1. Comparison of father-son relationship in Chinese and American films

    Institute of Scientific and Technical Information of China (English)

    倪秀飞

    2015-01-01

    The depiction of human emotions is never lacking in filmography, and affection between family members accounts for the top spot to become the most deeply touching one, especially the father-son relationship. Compared with mother-daughter and mother-son relationship, father-son relationship is often full of tension, turning out to be more introverted. So, in which way do films and television shows at home and broad represent vividly and truly about the father-child relationship?

  2. Self-coordination of parameter conflicts in D-SON architectures: A Markov Decision Process Framework

    OpenAIRE

    Moysen, Jessica; Giupponi, Lorenza

    2015-01-01

    We consider a distributed SON (D-SON) architecture where the interaction of different self-organizing network (SON) functions negatively affect the performances of the system. This is referred to in 3rd Generation Partnership Project (3GPP) as a SON conflict, which needs to be handled by means of a self-coordination framework. We focus on a functional architecture and a theoretical framework based on the theory of Markov decision process (MDP) for the self-coordination of different actions ta...

  3. Radiosensitization of metformin in pancreatic cancer cells via abrogating the G2 checkpoint and inhibiting DNA damage repair.

    Science.gov (United States)

    Wang, Zheng; Lai, Song-Tao; Ma, Ning-Yi; Deng, Yun; Liu, Yong; Wei, Dong-Ping; Zhao, Jian-Dong; Jiang, Guo-Liang

    2015-12-01

    Recent evidences have demonstrated the potential of metformin as a novel agent for cancer prevention and treatment. Here, we investigated its ability of radiosensitization and the underlying mechanisms in human pancreatic cancer cells. In this study, we found that metformin at 5 mM concentration enhanced the radiosensitivity of MIA PaCa-2 and PANC-1 cells, with sensitization enhancement ratios of 1.39 and 1.27, respectively. Mechanistically, metformin caused abrogation of the G2 checkpoint and increase of mitotic catastrophe, associated with suppression of Wee1 kinase and in turn CDK1 Tyr15 phosphorylation. Furthermore, metformin inhibited both expression and irradiation-induced foci formation of Rad51, a key player in homologous recombination repair, ultimately leading to persistent DNA damage, as reflected by γ-H2AX and 53BP1 signaling. Finally, metformin-mediated AMPK/mTOR/p70S6K was identified as a possible upstream pathway controlling translational regulation of Wee1 and Rad51. Our data suggest that metformin radiosensitizes pancreatic cancer cells in vitro via abrogation of the G2 checkpoint and inhibition of DNA damage repair. However, the in vivo study is needed to further confirm the findings from the in vitro study. PMID:26304716

  4. Radiosensitization of metformin in pancreatic cancer cells via abrogating the G2 checkpoint and inhibiting DNA damage repair.

    Science.gov (United States)

    Wang, Zheng; Lai, Song-Tao; Ma, Ning-Yi; Deng, Yun; Liu, Yong; Wei, Dong-Ping; Zhao, Jian-Dong; Jiang, Guo-Liang

    2015-12-01

    Recent evidences have demonstrated the potential of metformin as a novel agent for cancer prevention and treatment. Here, we investigated its ability of radiosensitization and the underlying mechanisms in human pancreatic cancer cells. In this study, we found that metformin at 5 mM concentration enhanced the radiosensitivity of MIA PaCa-2 and PANC-1 cells, with sensitization enhancement ratios of 1.39 and 1.27, respectively. Mechanistically, metformin caused abrogation of the G2 checkpoint and increase of mitotic catastrophe, associated with suppression of Wee1 kinase and in turn CDK1 Tyr15 phosphorylation. Furthermore, metformin inhibited both expression and irradiation-induced foci formation of Rad51, a key player in homologous recombination repair, ultimately leading to persistent DNA damage, as reflected by γ-H2AX and 53BP1 signaling. Finally, metformin-mediated AMPK/mTOR/p70S6K was identified as a possible upstream pathway controlling translational regulation of Wee1 and Rad51. Our data suggest that metformin radiosensitizes pancreatic cancer cells in vitro via abrogation of the G2 checkpoint and inhibition of DNA damage repair. However, the in vivo study is needed to further confirm the findings from the in vitro study.

  5. SON68 glass dissolution driven by magnesium silicate precipitation

    Science.gov (United States)

    Fleury, Benjamin; Godon, Nicole; Ayral, André; Gin, Stéphane

    2013-11-01

    Experimental results are reported on the effect of magnesium silicate precipitation on the mechanisms and rate of borosilicate glass dissolution. Leaching experiments with SON68 glass, a borosilicate containing no Mg, were carried out in initially deionized water at 50 °C with a glass-surface-area-to-solution-volume ratio of 20,000 m-1. After 29 days of alteration the experimental conditions were modified by the addition of Mg to trigger the precipitation of Mg-silicate. Additional experiments were conducted to investigate the importance of other parameters such as pH or dissolved silica on the mechanisms of precipitation of Mg-silicates and their consequences on the glass dissolution rate. Mg-silicates precipitate immediately after Mg is added. The amount of altered glass increases with the quantity of added Mg, and is smaller when silicon is added in solution. A time lag is observed between the addition of magnesium and the resumption of glass alteration because silicon is first provided by partial dissolution of the previously formed alteration gel. It is shown that nucleation does not limit Mg-silicate precipitation. A pH above 8 is necessary for the phase to precipitate under the investigated experimental conditions. On the other hand the glass alteration kinetics limits the precipitation if the magnesium is supplied in solution at a non-limiting rate. The concentration of i in solution was analyzed as well as that of boron. The quantity of i released from the glass is estimated with the assumption that i and B are released congruently at the glass dissolution front. The remained quantity of the element i is then supposed to be in the gel or in the secondary phase. In this paper, we do not make a difference between gel and hydrated glass using the same word 'gel' whereas Gin et al. [40] makes this difference. Recent papers [40,41] discussed about different key issues related to the passivation properties of the alteration layer including the hydrated glass

  6. Factors Promoting Secure Attachment Relationships between Employed Mothers and Their Sons.

    Science.gov (United States)

    Benn, Rita K.

    1986-01-01

    Investigates factors associated with outcomes in attachment relationships between 30 well-educated, full-time working mothers and their 18-month-old firstborn sons. Suggests maternal employment effects on mother-son attachment are mediated primarily by a woman's affective state, which becomes manifested in her style of caregiving and child-care…

  7. Polyandrous females produce sons that are successful at post-copulatory competition.

    Science.gov (United States)

    Klemme, I; Bäumer, J; Eccard, J A; Ylönen, H

    2014-03-01

    Some of the genetic benefit hypotheses put forward to explain multiple male mating (polyandry) predict that sons of polyandrous females will have an increased competitive ability under precopulatory or post-copulatory competition via paternally inherited traits, such as attractiveness or fertilization efficiency. Here, we tested these predictions by comparing the competitive ability of sons of experimentally monandrous and polyandrous female bank voles (Myodes glareolus), while controlling for potential material and maternal effects. In female choice experiments, we found no clear preference for sons of either monandrous or polyandrous mothers. Moreover, neither male type was dominant over the other, indicating no advantage in precopulatory male contest competition. However, in competitive matings, sons of polyandrous mothers significantly increased their mating efforts (mating duration, intromission number). In line with this, paternity success was biased towards sons of polyandrous mothers. Because there was no evidence for maternal effects, our results suggest that female bank voles gain genetic benefits from polyandry.

  8. Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator.

    Science.gov (United States)

    Ghosh, Asish K; Bhattacharyya, Swati; Wei, Jun; Kim, Suyeon; Barak, Yaacov; Mori, Yasuji; Varga, John

    2009-09-01

    Ligands of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) abrogate the stimulation of collagen gene transcription induced by transforming growth factor-beta (TGF-beta). Here, we delineate the mechanisms underlying this important novel physiological function for PPAR-gamma in connective tissue homeostasis. First, we demonstrated that antagonistic regulation of TGF-beta activity by PPAR-gamma ligands involves cellular PPAR-gamma, since 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) failed to block TGF-beta-induced responses in either primary cultures of PPAR-gamma-null murine embryonic fibroblasts, or in normal human skin fibroblasts with RNAi-mediated knockdown of PPAR-gamma. Next, we examined the molecular basis underlying the abrogation of TGF-beta signaling by PPAR-gamma in normal human fibroblasts in culture. The results demonstrated that Smad-dependent transcriptional responses were blocked by PPAR-gamma without preventing Smad2/3 activation. In contrast, the interaction between activated Smad2/3 and the transcriptional coactivator and histone acetyltransferase p300 induced by TGF-beta, and the accumulation of p300 on consensus Smad-binding DNA sequences and histone H4 hyperacetylation at the COL1A2 locus, were all prevented by PPAR-gamma. Wild-type p300, but not a mutant form of p300 lacking functional histone acetyltransferase, was able to restore TGF-beta-induced stimulation of COL1A2 in the presence of PPAR-gamma ligands. Collectively, these results indicate that PPAR-gamma blocked Smad-mediated transcriptional responses by preventing p300 recruitment and histone H4 hyperacetylation, resulting in the inhibition of TGF-beta-induced collagen gene expression. Pharmacological activation of PPAR-gamma thus may represent a novel therapeutic approach to target p300-dependent TGF-beta profibrotic responses such as stimulation of collagen gene expression.

  9. Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice.

    Directory of Open Access Journals (Sweden)

    Lea-Maxie Haag

    Full Text Available BACKGROUND: The zoonotic pathogen Campylobacter jejuni is a leading cause of bacterial foodborne enterocolitis in humans worldwide. The understanding of immunopathology underlying human campylobacteriosis is hampered by the fact that mice display strong colonization resistance against the pathogen due to their host specific gut microbiota composition. METHODOLOGY/PRINCIPAL FINDINGS: Since the microbiota composition changes significantly during intestinal inflammation we dissected factors contributing to colonization resistance against C. jejuni in murine ileitis, colitis and in infant mice. In contrast to healthy animals C. jejuni could stably colonize mice suffering from intestinal inflammation. Strikingly, in mice with Toxoplasma gondii-induced acute ileitis, C. jejuni disseminated to mesenteric lymphnodes, spleen, liver, kidney, and blood. In infant mice C. jejuni infection induced enterocolitis. Mice suffering from intestinal inflammation and C. jejuni susceptible infant mice displayed characteristical microbiota shifts dominated by increased numbers of commensal Escherichia coli. To further dissect the pivotal role of those distinct microbiota shifts in abrogating colonization resistance, we investigated C. jejuni infection in healthy adult mice in which the microbiota was artificially modified by feeding live commensal E. coli. Strikingly, in animals harboring supra-physiological intestinal E. coli loads, colonization resistance was significantly diminished and C. jejuni infection induced enterocolitis mimicking key features of human campylobacteriosis. CONCLUSION/SIGNIFICANCE: Murine colonization resistance against C. jejuni is abrogated by changes in the microbiota composition towards elevated E. coli loads during intestinal inflammation as well as in infant mice. Intestinal inflammation and microbiota shifts thus represent potential risk factors for C. jejuni infection. Corresponding interplays between C. jejuni and microbiota might

  10. Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase.

    Science.gov (United States)

    Okada, Motoi; Kim, Ha Won; Matsu-ura, Kaoru; Wang, Yi-Gang; Xu, Meifeng; Ashraf, Muhammad

    2016-01-01

    Previously, we reported that a novel subpopulation of young mesenchymal stem cells (YMSCs) existed in old bone marrow, which possessed high antiaging properties as well as excellent efficacy for cardiac repair. MicroRNAs (miRNAs) have emerged as key regulators in post-transcriptional gene expression programs, and however, it is unknown whether miRNAs directly control stem cell senescence. Here we present the first evidence that miR-195 overexpressed in old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging. MiRNAs profiling analysis in YMSCs and OMSCs by microarray showed that miR-140, miR-146a/b, and miR-195 were significantly upregulated in OMSCs, which led us to hypothesize that these are age-induced miRNAs involved in stem cell senescence. Of these miRNAs, we found miR-195 directly targeted 3'-untranslated region of Tert gene by computational target prediction analysis and luciferase assay, and knockdown of miR-195 significantly increased Tert expression in OMSCs. Strikingly, miR-195 inhibition significantly induced telomere relengthening in OMSCs along with reduced expression of senescence-associated β-galactosidase. Moreover, silencing miR-195 in OMSCs by transfection of miR-195 inhibitor significantly restored antiaging factors expression including Tert and Sirt1 as well as phosphorylation of Akt and FOXO1. Notably, abrogation of miR-195 markedly restored proliferative abilities in OMSCs. Transplantation of OMSCs with knocked out miR-195 reduced infarction size and improved LV function. In conclusion, rejuvenation of aged stem cells by miR-195 inhibition would be a promising autologous therapeutic strategy for cardiac repair in the elderly patients. PMID:26390028

  11. Abrogation of prostaglandin E-EP4 signaling in osteoblasts prevents the bone destruction induced by human prostate cancer metastases.

    Science.gov (United States)

    Watanabe, Kenta; Tominari, Tsukasa; Hirata, Michiko; Matsumoto, Chiho; Maruyama, Takayuki; Murphy, Gillian; Nagase, Hideaki; Miyaura, Chisato; Inada, Masaki

    2016-09-01

    The metastasis of tumors to bone is known to be promoted by prostaglandin E2 (PGE2) produced by the tumor host stromal tissue. Although bone metastases frequently occur in prostate cancer patients, the significance of PGE2 in stromal responses to the tumor is not known. In this study, we report that PGE2 and its receptor EP4 play a pivotal role in bone destruction and metastasis in an experimental metastasis model of prostate cancer in nude mice. Using human prostate cancer PC-3 cells that are stably transfected with luciferase, we showed that the development of bone metastasis was accompanied by increased osteoclastic bone resorption in the bone metastasis microenvironment, and could be abrogated by an EP4 receptor antagonist. The growth of PC-3 cells in vitro was not influenced by PGE2 or by the EP4 receptor. However, cell-cell interactions between fixed PC-3 cells and host osteoblasts induced PGE2 production and RANKL expression in the osteoblasts. Addition of an EP4 antagonist suppressed both PGE2 and RANKL expression induced by the PC3-osteoblast interaction, which would have consequent effects on osteoclast activation and osteolysis. These results indicate that the blockage of PGE2-EP4 signaling prevents the bone destruction required for prostate cancer metastases, and that this is, in part due to the abrogation of bone cell responses. The study provides further evidence that an EP4 antagonist is a candidate for the treatment of prostate cancer in the blockade of bone metastasis. PMID:27450806

  12. Older parents enjoy better filial piety and care from daughters than sons in China

    DEFF Research Database (Denmark)

    Zeng, Yi; George, Linda; Sereny, Melanie;

    2016-01-01

    with having son(s), having daughter(s) is significantly more beneficial at older ages in China, with regard to maintaining higher cognitive capacity and reducing mortality risk. Such daughter advantages in providing emotional care to older parents are more profound among the oldest-old aged 80+ as compared...... with the young-old aged 65 to 79 and surprisingly more profound in rural areas as compared with urban areas, even though son preference is much more common among rural residents. DISCUSSION: We describe how educational campaigns aimed at informing the public about the benefits of daughter(s) for older parents...

  13. Parent-son decision-making about human papillomavirus vaccination: a qualitative analysis

    Directory of Open Access Journals (Sweden)

    Alexander Andreia B

    2012-12-01

    Full Text Available Abstract Background Licensed for use in males in 2009, Human Papillomavirus (HPV vaccination rates in adolescent males are extremely low. Literature on HPV vaccination focuses on females, adult males, or parents of adolescent males, without including adolescent males or the dynamics of the parent-son interaction that may influence vaccine decision-making. The purpose of this paper is to examine the decision-making process of parent-son dyads when deciding whether or not to get vaccinated against HPV. Methods Twenty-one adolescent males (ages 13–17, with no previous HPV vaccination, and their parents/guardians were recruited from adolescent primary care clinics serving low to middle income families in a large Midwestern city. Dyad members participated in separate semi-structured interviews assessing the relative role of the parent and son in the decision regarding HPV vaccination. Interviews were recorded, transcribed, and coded using inductive content analysis. Results Parents and sons focused on protection as a reason for vaccination; parents felt a need to protect their child, while sons wanted to protect their own health. Parents and sons commonly misinterpreted the information about the vaccine. Sons were concerned about an injection in the penis, while some parents and sons thought the vaccine would protect them against other sexually transmitted infections including Herpes, Gonorrhea, and HIV. Parents and sons recalled that the vaccine prevented genital warts rather than cancer. The vaccine decision-making process was rapid and dynamic, including an initial reaction to the recommendation for HPV vaccine, discussion between parent and son, and the final vaccine decision. Provider input was weighed in instances of initial disagreement. Many boys felt that this was the first health care decision that they had been involved in. Dyads which reported shared decision-making were more likely to openly communicate about sexual issues than those

  14. Maternal pre-pregnancy body mass index and pubertal development among sons

    DEFF Research Database (Denmark)

    Hounsgaard, M L; Håkonsen, L B; Vested, A;

    2014-01-01

    that during pregnancy in 1984-1987 were enrolled in a mother-child cohort and gave information on their pre-pregnancy height and weight from which we calculated their BMI. Information on sons' pubertal development, assessed by age when starting regular shaving, voice break, acne and first nocturnal emission...... indicators of pubertal development, results also indicated earlier pubertal development among sons of obese mothers. After excluding sons of underweight mothers in a subanalysis, we observed an inverse trend between maternal pre-pregnancy BMI and age at regular shaving, acne and first nocturnal emission...

  15. SON controls cell-cycle progression by coordinated regulation of RNA splicing.

    Science.gov (United States)

    Ahn, Eun-Young; DeKelver, Russell C; Lo, Miao-Chia; Nguyen, Tuyet Ann; Matsuura, Shinobu; Boyapati, Anita; Pandit, Shatakshi; Fu, Xiang-Dong; Zhang, Dong-Er

    2011-04-22

    It has been suspected that cell-cycle progression might be functionally coupled with RNA processing. However, little is known about the role of the precise splicing control in cell-cycle progression. Here, we report that SON, a large Ser/Arg (SR)-related protein, is a splicing cofactor contributing to efficient splicing of cell-cycle regulators. Downregulation of SON leads to severe impairment of spindle pole separation, microtubule dynamics, and genome integrity. These molecular defects result from inadequate RNA splicing of a specific set of cell-cycle-related genes that possess weak splice sites. Furthermore, we show that SON facilitates the interaction of SR proteins with RNA polymerase II and other key spliceosome components, suggesting its function in efficient cotranscriptional RNA processing. These results reveal a mechanism for controlling cell-cycle progression through SON-dependent constitutive splicing at suboptimal splice sites, with strong implications for its role in cancer and other human diseases.

  16. On the domain wall partition functions of level-1 affine so(n) vertex models

    OpenAIRE

    Dow, A.; Foda, O.

    2006-01-01

    We derive determinant expressions for domain wall partition functions of level-1 affine so(n) vertex models, n >= 4, at discrete values of the crossing parameter lambda = m pi / 2(n-3), m in Z, in the critical regime.

  17. Que son las Cochinillas de los Cotrus (Naranjos, Limoneros, Mandarinos, etc. y como se Combaten.

    Directory of Open Access Journals (Sweden)

    Posada Sinisterra. Belisario

    1942-04-01

    Full Text Available Las cochinillas son insectos de aspecto variado. Son llamados también insectos-escamas porque la mayoría de ellos viven protegidos por una concha o escama de forma y coloración diversa. Las especies que en seguida se describen tienen un ciclo biológico muy similar. Se reproducen por medio de huevos que depositan las hembras bajo la escama.

  18. The Demand for Sons: Evidence from Divorce, Fertility, and Shotgun Marriage

    OpenAIRE

    Gordon B. Dahl; Moretti, Enrico

    2004-01-01

    This paper shows how parental preferences for sons versus daughters affect divorce, child custody, marriage, shotgun marriage when the sex of the child is known before birth, and fertility stopping rules. We document that parents with girls are significantly more likely to be divorced, that divorced fathers are more likely to have custody of their sons, and that women with only girls are substantially more likely to have never been married. Perhaps the most striking evidence comes from the an...

  19. Transcendence and Son Jarocho as Practiced in the San Francisco Bay Area

    OpenAIRE

    Sacolick, Robin

    2016-01-01

    AbstractTranscendence and Son Jarocho as Practiced in the San Francisco Bay AreaRobin SacolickPeople of emerging or non-dominant ethnicities in multicultural, diasporic societies need ways to establish identities, merge strengths, and transcend difficulties. This study explores one way: community practices, by Latina/os and others in the Bay Area, of son jarocho, a centuries-old genre of Mexican music, dance and poetry. While their project revives traditional folklore, it also offers experien...

  20. Child Gender and Parental Inputs: No More Son Preference in Korea?

    OpenAIRE

    Eleanor Jawon Choi; Jisoo Hwang

    2015-01-01

    Sex ratio at birth remains highly skewed in Asian countries due to son preference. In South Korea, however, it has declined to the natural ratio. In this paper, we investigate whether son preference has disappeared in Korea by analyzing parents' time and monetary inputs by the sex of their child. We exploit randomness of the first child's sex to overcome potential bias from endogenous fertility decisions. Our findings show that mothers are more likely to work after having a girl, girls spend ...

  1. La notion de zone de connexion biologique. Son application en aménagement du territoire

    Directory of Open Access Journals (Sweden)

    Philippe Ménard

    2001-12-01

    Full Text Available La notion de zone de connexion biologique a été définie comme un espace fonctionnel d'échange biologique permettant le maintien des biodiversités locales. Nous avons testé son intérêt et son application dans le cas d'un paysage complexe très fragmenté, traversé par un projet autoroutier.

  2. Some reflections on a case of mother/adolescent son incest.

    Science.gov (United States)

    Shengold, L

    1980-01-01

    A rare case of mother/adolescent son incest is presented. The son, treated in analysis, was not psychotic. Questions are raised about why father/daughter incest appears to be much more common than mother/son incest. Part of the answer, I speculate, has to do with the special psychic dangers for both mother and son, perhaps phylogenetically-based, which attach to the fantasy and the possibility of impregnating the mother. Where the incest taboo is violated, the primary responsibility would appear to be the parent's; the parent is frequently motivated by a compulsion to repeat his or her own incestuous past. In the case presented the probably psychotic mother had raised her son to look like a girl for several years, and he had been the victim of a homosexual assault at the age of 6. The incest at puberty seems to have helped him reverse a psychic position of subjection to the pre-oedipal mother, to have modified his rage and reinforced his masculinity. It also produced some of the arrogance, alongside a need for failure and punishment that evoke the legend of Oedipus. The mother, fearful of the possibility of getting pregnant, had abruptly stopped the incest. It had been repressed, and became conscious again when the son entered analysis. He then left his treatment without being able to work through much of the terror consequent to the consummation of incest, and with some of the feeling of oedipal triumph retained.

  3. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells

    Institute of Scientific and Technical Information of China (English)

    Rong-guang SHAO; Chun-Xia CAO; Yves POMMIER

    2004-01-01

    AIM: To investigate whether 7-hydroxystaurosporine (UCN-01) affects cell cycle progression in arabinosylcytosine (ara-C) treated human colon carcinoma HT-29 cells. METHODS: Cytotoxicity, DNA synthesis, cell cycle distribution,protein level, and kinase activity were determined by clonogenic assay, flow cytometry, DNA synthesis assay,immunoblotting, and kinase assays, respectively. RESULTS: UCN-01 abrogated an S/G2-phase checkpoint in HT29 cells treated with ara-C. When UCN-01 was added after treatment with ara-C, the rate of recovery of DNA synthesis was enhanced and colony-forming ability diminished. Thus, premature recovery of DNA synthesis was associated with increased cytotoxicity. Measurements of cyclin A and B protein levels, Cdk2 and Cdc2 kinase activities, Cdc25C phosphorylation, and Chkl kinase activity were consistent with UCN-01-induced abrogation of the S/G2-phase checkpoint in ara-C treated cells. CONCLUSION: The abrogation of the S/G2 checkpoint may be due to inhibition of Chkl kinase by UCN-01. The enhanced cytotoxicity produced when UCN-01 was combined with ara-C suggested a rationale for the use of this drug combination for tumors that might be susceptible to cell cycle checkpoint abrogation.

  4. JAK inhibitors suppress t(8;21) fusion protein-induced leukemia

    OpenAIRE

    Lo, Miao-Chia; Peterson, Luke F.; Yan, Ming; Cong, Xiuli; Hickman, Justin H.; DeKelver, Russel C.; Niewerth, Denise; Zhang, Dong-Er

    2013-01-01

    Oncogenic mutations in components of the JAK/STAT pathway, including those in cytokine receptors and JAKs, lead to increased activity of downstream signaling and are frequently found in leukemia and other hematological disorders. Thus, small-molecule inhibitors of this pathway have been the focus of targeted therapy in these hematological diseases. We previously showed that t(8;21) fusion protein AML1-ETO and its alternatively spliced variant AML1-ETO9a (AE9a) enhance the JAK/STAT pathway via...

  5. Has Their Son Been Vaccinated? Beliefs About Other Parents Matter for Human Papillomavirus Vaccine.

    Science.gov (United States)

    Schuler, Christine L; Coyne-Beasley, Tamera

    2016-07-01

    The goal of this study was to determine if parents' beliefs about social norms of human papillomavirus (HPV) vaccination for sons were associated with knowledge of HPV, intention to vaccinate sons, or beliefs about side effects. A cross-sectional, survey-based study of parents with sons was performed in 2010. Fisher's exact tests were used to examine associations between demographics and responses about social norms. Multivariate logistic regression models examined beliefs about social norms of male HPV vaccination and primary outcomes. Few parents agreed that others were vaccinating sons (n = 31/267, 12%), including 1% responding strongly agree and 11% responding agree. Most parents, 52%, disagreed that others were vaccinating (40% disagree, 11% strongly disagree), and 37% chose prefer not to answer regarding others' vaccination practices. Hispanic parents and those with a high school education or less were significantly more likely to choose prefer not to answer than their respective counterparts regarding vaccination norms. In multivariate models, parents agreeing others were vaccinating sons had greater odds of having high knowledge of HPV (adjusted odds ratio [aOR] high vs low knowledge 3.15, 95% confidence interval [CI] 1.13, 8.77) and increased intention to vaccinate sons (n = 243, aOR = 4.41, 95% CI = 1.51, 12.89). Beliefs about side effects were not significantly associated with beliefs about social norms. Parents' beliefs about others' vaccination practices are important with regard to knowledge of HPV and intention to vaccinate sons. Studying how various public messages about HPV vaccine may influence normative beliefs could be relevant to improving vaccination coverage.

  6. Has Their Son Been Vaccinated? Beliefs About Other Parents Matter for Human Papillomavirus Vaccine.

    Science.gov (United States)

    Schuler, Christine L; Coyne-Beasley, Tamera

    2016-07-01

    The goal of this study was to determine if parents' beliefs about social norms of human papillomavirus (HPV) vaccination for sons were associated with knowledge of HPV, intention to vaccinate sons, or beliefs about side effects. A cross-sectional, survey-based study of parents with sons was performed in 2010. Fisher's exact tests were used to examine associations between demographics and responses about social norms. Multivariate logistic regression models examined beliefs about social norms of male HPV vaccination and primary outcomes. Few parents agreed that others were vaccinating sons (n = 31/267, 12%), including 1% responding strongly agree and 11% responding agree. Most parents, 52%, disagreed that others were vaccinating (40% disagree, 11% strongly disagree), and 37% chose prefer not to answer regarding others' vaccination practices. Hispanic parents and those with a high school education or less were significantly more likely to choose prefer not to answer than their respective counterparts regarding vaccination norms. In multivariate models, parents agreeing others were vaccinating sons had greater odds of having high knowledge of HPV (adjusted odds ratio [aOR] high vs low knowledge 3.15, 95% confidence interval [CI] 1.13, 8.77) and increased intention to vaccinate sons (n = 243, aOR = 4.41, 95% CI = 1.51, 12.89). Beliefs about side effects were not significantly associated with beliefs about social norms. Parents' beliefs about others' vaccination practices are important with regard to knowledge of HPV and intention to vaccinate sons. Studying how various public messages about HPV vaccine may influence normative beliefs could be relevant to improving vaccination coverage. PMID:25595021

  7. 29 CFR 825.122 - Definitions of spouse, parent, son or daughter, next of kin of a covered servicemember, adoption...

    Science.gov (United States)

    2010-07-01

    ... of a covered servicemember, adoption, foster care, son or daughter on active duty or call to active..., adoption, foster care, son or daughter on active duty or call to active duty status, son or daughter of a... at 29 CFR 1630.2(h), (i), and (j), issued by the Equal Employment Opportunity Commission under...

  8. The Power of a Single Mother: The Influence of Black Women on Their Sons' Academic Performance

    Science.gov (United States)

    Robinson, Quintin L.; Werblow, Jacob

    2013-01-01

    This study examines the ways single Black mothers contribute to the educational success of their 11th-grade sons, despite the fact that their sons are enrolled in "failing schools." Data from five interviews and one focus group reveal common characteristics of how single-Black mothers help their sons beat the odds.

  9. Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells.

    Science.gov (United States)

    Fedorenko, I V; Abel, E V; Koomen, J M; Fang, B; Wood, E R; Chen, Y A; Fisher, K J; Iyengar, S; Dahlman, K B; Wargo, J A; Flaherty, K T; Sosman, J A; Sondak, V K; Messina, J L; Gibney, G T; Smalley, K S M

    2016-03-10

    The mechanisms by which some melanoma cells adapt to Serine/threonine-protein kinase B-Raf (BRAF) inhibitor therapy are incompletely understood. In the present study, we used mass spectrometry-based phosphoproteomics to determine how BRAF inhibition remodeled the signaling network of melanoma cell lines that were BRAF mutant and PTEN null. Short-term BRAF inhibition was associated with marked changes in fibronectin-based adhesion signaling that were PTEN dependent. These effects were recapitulated through BRAF siRNA knockdown and following treatment with chemotherapeutic drugs. Increased fibronectin expression was also observed in mouse xenograft models as well as specimens from melanoma patients undergoing BRAF inhibitor treatment. Analysis of a melanoma tissue microarray showed loss of PTEN expression to predict for a lower overall survival, with a trend for even lower survival being seen when loss of fibronectin was included in the analysis. Mechanistically, the induction of fibronectin limited the responses of these PTEN-null melanoma cell lines to vemurafenib, with enhanced cytotoxicity observed following the knockdown of either fibronectin or its receptor α5β1 integrin. This in turn abrogated the cytotoxic response to BRAF inhibition via increased AKT signaling, which prevented the induction of cell death by maintaining the expression of the pro-survival protein Mcl-1. The protection conveyed by the induction of FN expression could be overcome through combined treatment with a BRAF and PI3K inhibitor. PMID:26073081

  10. An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gräsbeck syndrome in dogs.

    Science.gov (United States)

    Fyfe, John C; Hemker, Shelby L; Venta, Patrick J; Fitzgerald, Caitlin A; Outerbridge, Catherine A; Myers, Sherry L; Giger, Urs

    2013-08-01

    Cobalamin malabsorption accompanied by selective proteinuria is an autosomal recessive disorder known as Imerslund-Gräsbeck syndrome in humans and was previously described in dogs due to amnionless (AMN) mutations. The resultant vitamin B12 deficiency causes dyshematopoiesis, lethargy, failure to thrive, and life-threatening metabolic disruption in the juvenile period. We studied 3 kindreds of border collies with cobalamin malabsorption and mapped the disease locus in affected dogs to a 2.9Mb region of homozygosity on canine chromosome 2. The region included CUBN, the locus encoding cubilin, a peripheral membrane protein that in concert with AMN forms the functional intrinsic factor-cobalamin receptor expressed in ileum and a multi-ligand receptor in renal proximal tubules. Cobalamin malabsorption and proteinuria comprising CUBN ligands were demonstrated by radiolabeled cobalamin uptake studies and SDS-PAGE, respectively. CUBN mRNA and protein expression were reduced ~10 fold and ~20 fold, respectively, in both ileum and kidney of affected dogs. DNA sequencing demonstrated a single base deletion in exon 53 predicting a translational frameshift and early termination codon likely triggering nonsense mediated mRNA decay. The mutant allele segregated with the disease in the border collie kindred. The border collie disorder indicates that a CUBN mutation far C-terminal from the intrinsic factor-cobalamin binding site can abrogate receptor expression and cause Imerslund-Gräsbeck syndrome. PMID:23746554

  11. Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint

    Energy Technology Data Exchange (ETDEWEB)

    Nakadate, Yusuke [Shien-Lab, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Department of Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan); Kodera, Yasuo; Kitamura, Yuka [Shien-Lab, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Tachibana, Taro [Department of Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan); Tamura, Tomohide [Division of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Koizumi, Fumiaki, E-mail: fkoizumi@ncc.go.jp [Division of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)

    2013-11-29

    Highlights: •Radiosensitization by PARG silencing was observed in multiple lung cancer cells. •PAR accumulation was enhanced by PARG silencing after DNA damage. •Radiation-induced G2/M arrest and checkpoint activation were impaired by PARG siRNA. -- Abstract: Poly(ADP-ribose) glycohydrolase (PARG) is a major enzyme that plays a role in the degradation of poly(ADP-ribose) (PAR). PARG deficiency reportedly sensitizes cells to the effects of radiation. In lung cancer, however, it has not been fully elucidated. Here, we investigated whether PARG siRNA contributes to an increased radiosensitivity using 8 lung cancer cell lines. Among them, the silencing of PARG induced a radiosensitizing effect in 5 cell lines. Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown. On the other hand, a similar effect was not observed in H520 cells, which did not exhibit a radiosensitizing effect. Consistent with a cell cycle analysis, radiation-induced checkpoint signals were not well activated in the PC-14 and A427 cells when treated with PARG siRNA. These results suggest that the increased sensitivity to radiation induced by PARG knockdown occurs through the abrogation of radiation-induced G2/M arrest and checkpoint activation in lung cancer cells. Our findings indicate that PARG could be a potential target for lung cancer treatments when used in combination with radiotherapy.

  12. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

    Science.gov (United States)

    de Jong, Petrus R.; Taniguchi, Koji; Harris, Alexandra R.; Bertin, Samuel; Takahashi, Naoki; Duong, Jen; Campos, Alejandro D.; Powis, Garth; Corr, Maripat; Karin, Michael; Raz, Eyal

    2016-01-01

    The ERK1/2 MAPK signalling module integrates extracellular cues that induce proliferation and differentiation of epithelial lineages, and is an established oncogenic driver, particularly in the intestine. However, the interrelation of the ERK1/2 module relative to other signalling pathways in intestinal epithelial cells and colorectal cancer (CRC) is unclear. Here we show that loss of Erk1/2 in intestinal epithelial cells results in defects in nutrient absorption, epithelial cell migration and secretory cell differentiation. However, intestinal epithelial cell proliferation is not impeded, implying compensatory mechanisms. Genetic deletion of Erk1/2 or pharmacological targeting of MEK1/2 results in supraphysiological activity of the ERK5 pathway. Furthermore, targeting both pathways causes a more effective suppression of cell proliferation in murine intestinal organoids and human CRC lines. These results suggest that ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in CRC. PMID:27187615

  13. Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

    Energy Technology Data Exchange (ETDEWEB)

    Prins, Kathleen C.; Delpeut, Sebastien; Leung, Daisy W.; Reynard, Olivier; Volchkova, Valentina A.; Reid, St. Patrick; Ramanan, Parameshwaran; Cárdenas, Washington B.; Amarasinghe, Gaya K.; Volchkov, Viktor E.; Basler, Christopher F. (CNRS-INSERM); (Mount Sinai Hospital); (LB-Ecuador); (Iowa State)

    2010-10-11

    Ebola virus (EBOV) protein VP35 is a double-stranded RNA (dsRNA) binding inhibitor of host interferon (IFN)-{alpha}/{beta} responses that also functions as a viral polymerase cofactor. Recent structural studies identified key features, including a central basic patch, required for VP35 dsRNA binding activity. To address the functional significance of these VP35 structural features for EBOV replication and pathogenesis, two point mutations, K319A/R322A, that abrogate VP35 dsRNA binding activity and severely impair its suppression of IFN-{alpha}/{beta} production were identified. Solution nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography reveal minimal structural perturbations in the K319A/R322A VP35 double mutant and suggest that loss of basic charge leads to altered function. Recombinant EBOVs encoding the mutant VP35 exhibit, relative to wild-type VP35 viruses, minimal growth attenuation in IFN-defective Vero cells but severe impairment in IFN-competent cells. In guinea pigs, the VP35 mutant virus revealed a complete loss of virulence. Strikingly, the VP35 mutant virus effectively immunized animals against subsequent wild-type EBOV challenge. These in vivo studies, using recombinant EBOV viruses, combined with the accompanying biochemical and structural analyses directly correlate VP35 dsRNA binding and IFN inhibition functions with viral pathogenesis. Moreover, these studies provide a framework for the development of antivirals targeting this critical EBOV virulence factor.

  14. Son Preference in India: Shedding Light on the North-South Gradient

    Directory of Open Access Journals (Sweden)

    Daniela Klaus

    2014-12-01

    Full Text Available Dieser Beitrag liegt nur in englischer Sprache vor.Son preference is widespread in India and deep-rooted in its history. It is a matter of concern because it produces an imbalanced juvenile sex ratio. There are far fewer girls than boys. The figures vary greatly among the Indian states suggesting a major north-south gradient in son preference accompanied by a minor west-east gradient. The aim of this paper is to explain the regional pattern. We provide an application of the value of children-approach according to which the decision to have children is made on the calculus of benefits and costs related to children. In the light of the socioeconomic and sociocultural background in India, we propose that (potential parents’ expectations of benefits and costs are biased in favour of sons. This is suggested, therefore, as the key motivation for the preference for male offspring. However, region-specifics in the level of affluence, the educational level, the mode of production, the meaning and importance of religion, and the kinship regime are assumed to produce stronger son preference in north India compared to south India. This mediation-model is tested using the Indian sub-sample of the international Value of Children-study. Data were collected in Uttar Pradesh (north-central India and Puducherry (south-east India. Mothers aged 16 to 65 were interviewed in 2002 and 2010. Based on 1,173 respondents, a structural equation model was carried out to test the hypothesised composition effects related to the region and the mediating position of sex-specific benefits and costs. Initial findings confirm that the national son preference pattern is more likely to be found among north Indian mothers than south Indian mothers. As assumed, the sex-specific balance of benefits and costs contributes to the explanation of son preference. However, there is little evidence that the benefits and costs mediate between the region-specific socioeconomic and

  15. Two Dimensional Analytical Modeling for SOI and SON MOSFET and Their Performance Comparison

    Directory of Open Access Journals (Sweden)

    Saptarsi Ghosh

    2011-01-01

    Full Text Available During last few decade continuous device performance improvements have been achieved through a combination of device scaling, new device structures and material property improvement to its fundamental limits. Conventional silicon (bulk CMOS technology can’t overcome the fundamental physical limitations belong to sub-micro or nanometer region which leads to alternative device technology like Silicon-on-Insulator (SOI technology and its recent innovative modification Silicon-On-Nothing (SON MOSFET. Analytical simulation is very important to understand the relative performance of those devices under different structural and operational parameter variations. For present analytical simulation asymmetric structure of Silicon-On-Insulator (SOI MOSFET and Silicon-On-Nothing (SON MOSFET are considered. The proposed structure of SON MOSFET is similar to that of the SOI MOSFET with the only exception being the oxide layer here is substituted with air which has much lower permittivity than Silicon-dioxide. Variation of threshold voltage against effective channel lengths is compared for both the structures. From our simulation it is observed that the proposed SON model has lower drain to source current (IDS than SOI model. In our modeling based on solution of two dimensional Poisson’s equation short channel effects such as DIBL and fringing field effects are also taken into account. SON is found to provide better suppression of SCE s than SOI. The results predicted by our analytical simulation hold good agreement with experimental results.

  16. The deconfining phase transition of SO(N) gauge theories in 2+1 dimensions

    Science.gov (United States)

    Lau, Richard; Teper, Michael

    2016-03-01

    We calculate the deconfining temperature of SO(N ) gauge theories in 2+1 dimensions, and determine the order of the phase transition as a function of N , for various values of N ∈ [4 , 16]. We do so by extrapolating our lattice results to the infinite volume limit, and then to the continuum limit, for each value of N. We then extrapolate to the N =∞ limit and observe that the SO(N) and SU(N) deconfining temperatures agree in that limit. We find that the the deconfining temperatures of all the SO(N ) gauge theories appear to follow a single smooth function of N , despite the lack of a non-trivial centre for odd N . We also compare the deconfining temperatures of SO(6) with SU(4), and of SO(4) with SU(2) × SU(2), motivated by the fact that these pairs of gauge theories share the same Lie algebras.

  17. Maternal distancing strategies toward twin sons, one with mild hearing loss: a case study.

    Science.gov (United States)

    Muñoz-Silva, Alicia; Sánchez-García, Manuel

    2004-01-01

    The authors apply descriptive and sequential analyses to a mother's distancing strategies toward her 3-year-old twin sons in puzzle assembly and book reading tasks. One boy had normal hearing and the other a mild hearing loss (threshold: 30 dB). The results show that the mother used more distancing behaviors with the son with a hearing loss, and thus gave greater encouragement to this son's cognitive development. These results differ from those of previous studies of deaf or hard of hearing children, whose participants generally had severe or profound hearing loss. In those studies, parents of deaf children used more low-level distancing than parents of normally hearing children. The results of the present study are discussed in terms of their implications for the parenting of twins and of children with mild hearing loss.

  18. The Relationship between Paul and His Mother in Sons and Lovers

    Institute of Scientific and Technical Information of China (English)

    ZhangYanxia

    2010-01-01

    Sons and lovers is the greatest work written by D.H.Lawrence.In the novel,the mother,Mrs Morel devotes all her love on her sons,first on William,who dies after leaving home,then on her second son,Paul,and he also has the affection upon his mother.Thus it makes him incapable of dealing the relationship with other women.This Oedipus complex influences his life and emotion.How does this kind of emotion come into being? Why does Paul have this kind of abnormal love? Maybe there are a lot of reasons,and they will be discussed in detail in the following paragraphs.

  19. Chapitre II. La reproduction du son dans la légende

    OpenAIRE

    Pisano, Giusy

    2013-01-01

    La captation du son possède ses propres mythes et légendes, car, avant d’aboutir à une réalisation technique, une longue période de tentatives fantaisistes et maladroites s’est écoulée. Saisir le son de la voix humaine, pouvoir le conserver et le réécouter, est l’un de ces rêves qui rapprochent l’homme du domaine du sacré et le projettent dans un espace proche des forces mystérieuses de la nature. En fait, séparer la voix de son appareil physiologique et la réduire à une simple sonorité serai...

  20. Risk of cryptorchidism among sons of horticultural workers and farmers in Denmark

    DEFF Research Database (Denmark)

    Jørgensen, Kristian Tore; Jensen, Morten Søndergaard; Toft, Gunnar Vase;

    2014-01-01

    occupations. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated using Cox regression adjusting for parental age, birth years, parity, and geographical region. RESULTS: Sons of maternal farmers were at increased risk of cryptorchidism (157 cases; HR 1.31, 95% CI 1.12-1.53) compared to boys...... of mothers in other occupations (15 511 cases). Paternal occupation as farmer was unrelated to the risk among sons. Maternal occupation as a horticultural worker was associated with a non-significantly increased risk (72 cases; HR 1.20, 95% CI 0.95-1.52). A similar association was found for paternal......OBJECTIVES: Previous studies indicate an increased risk of cryptorchidism, incomplete testicular descent, among sons of women working with pesticides. This study assessed the risk of cryptorchidism among boys of parents employed as horticultural workers and farmers using nationwide registers...

  1. The relation of son preference and religion to induced abortion: the case of South Korea.

    Science.gov (United States)

    Chung, Woojin

    2007-09-01

    This paper explores the factors that influence the practice of induced abortion in a very low fertility society, with particular emphasis on son preference and three distinct religions: Confucianism, Buddhism and Christianity. Using multivariate logistic regression models fitted by the generalized estimating equation (GEE) method, this paper analysed the data collected by the 2000 Korea National Fertility and Family Health Survey of 6348 married women aged 15-49 years with a total of 1217 pregnancy outcomes. The results showed that the likelihood of induced abortions in women with two or more children, compared with those with one child, was significantly influenced by the sex composition of the previous children: odds ratio (OR)=12.71 (95% CI=5.49, 29.42) for women with only son(s), and OR=3.91 (95% CI=1.67, 9.14) for women with only daughter(s). At parity two, women with two sons were much more likely to have induced abortions than women with two daughters (OR=5.88, 95% CI=2.70, 12.85). Although Buddhist women were not significantly different from Confucian women in induced abortion practice, Christian women were much less likely than Confucian women to have an induced abortion (OR=0.39, 95% CI=0.18, 0.88 for women with only sons and OR=0.44, 95% CI=0.24, 0.81 for women with two children). This suggests that even in this very low fertility society, son preference and religious affiliation are significant predictors of women's practice of induced abortion. PMID:17381891

  2. Particle Swarm Optimization for Mobility Load Balancing SON in LTE Networks

    OpenAIRE

    Altman, Zwi; SALLEM, Soumaya; Nasri, Ridha; Sayrac, Berna; Clerc, Maurice

    2013-01-01

    This paper presents a self-optimizing solution for Mobility Load Balancing (MLB). The MLB-SON is performed in two phases. In the first, a MLB controller is designed using Multi-Objective Particle Swarm Optimization (MO-PSO) which incorporates a priori expert knowledge to considerably reduce the search space and optimization time. The dynamicity of the optimization phase is addressed. In the second phase, the controller is pushed into the base stations to implement the MLB SON. The method is a...

  3. Particle Swarm Optimization for Mobility Load Balancing SON in LTE Networks

    OpenAIRE

    Altman, Zwi; SALLEM, Soumaya; Nasri, Ridha; Sayrac, Berna; Clerc, Maurice

    2014-01-01

    This paper presents a self-optimizing solution for Mobility Load Balancing (MLB). The MLB-SON is performed in two phases. In the first, a MLB controller is designed using Multi-Objective Particle Swarm Optimization (MO-PSO) which incorporates a priori expert knowledge to considerably reduce the search space and optimization time. The dynamicity of the optimization phase is addressed. In the second phase, the controller is pushed into the base stations to implement the MLB SON. The method is a...

  4. The Legend, The Madman, and the Prophet a Memoir about Fathers and Sons

    OpenAIRE

    Thalman, Erik K.

    2015-01-01

    The Legend, the Madman, and the Prophet is a memoir about fathers and sons, about the experience of being a son of a man of the Rocky Mountains, a legend grown old. The narrative centers around my struggle with the fact that my father had grown old and sick while I was still young, and my consequent search for other fathers, employing two primary examples—a martial-arts instructor from my high-school years who was later exposed as a pedophile, and the eccentric figure of my ex-girlfriend’s we...

  5. La communication publique dans le monde arabe. Essai d’analyse de son émergence et de son développement

    OpenAIRE

    Hammami, Sadock

    2011-01-01

    Ce texte examine l’émergence et le développement de la communication publique dans le monde arabe. L’essor de la communication publique est lié à une série de dynamiques : construction et crise de l’Etat postcolonial, transformations des organisations publiques et mutations de la sphère des médias. Situé dans son contexte sociétal, l’essor de la communication publique nous renseigne sur les changements des modes de gestion politique et sur le statut des organisations publiques dans des sociét...

  6. Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

    Directory of Open Access Journals (Sweden)

    Hiroyuki Oshiumi

    Full Text Available The DEAD box helicase DDX3 assembles IPS-1 (also called Cardif, MAVS, or VISA in non-infected human cells where minimal amounts of the RIG-I-like receptor (RLR protein are expressed. DDX3 C-terminal regions directly bind the IPS-1 CARD-like domain as well as the N-terminal hepatitis C virus (HCV core protein. DDX3 physically binds viral RNA to form IPS-1-containing spots, that are visible by confocal microscopy. HCV polyU/UC induced IPS-1-mediated interferon (IFN-beta promoter activation, which was augmented by co-transfected DDX3. DDX3 spots localized near the lipid droplets (LDs where HCV particles were generated. Here, we report that HCV core protein interferes with DDX3-enhanced IPS-1 signaling in HEK293 cells and in hepatocyte Oc cells. Unlike the DEAD box helicases RIG-I and MDA5, DDX3 was constitutively expressed and colocalized with IPS-1 around mitochondria. In hepatocytes (O cells with the HCV replicon, however, DDX3/IPS-1-enhanced IFN-beta-induction was largely abrogated even when DDX3 was co-expressed. DDX3 spots barely merged with IPS-1, and partly assembled in the HCV core protein located near the LD in O cells, though in some O cells IPS-1 was diminished or disseminated apart from mitochondria. Expression of DDX3 in replicon-negative or core-less replicon-positive cells failed to cause complex formation or LD association. HCV core protein and DDX3 partially colocalized only in replicon-expressing cells. Since the HCV core protein has been reported to promote HCV replication through binding to DDX3, the core protein appears to switch DDX3 from an IFN-inducing mode to an HCV-replication mode. The results enable us to conclude that HCV infection is promoted by modulating the dual function of DDX3.

  7. Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs

    Energy Technology Data Exchange (ETDEWEB)

    Arumugam, Aadithya; Walsh, Stephanie B.; Xu, Jianmin; Afaq, Farrukh [Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294-0019 (United States); Elmets, Craig A. [Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294-0019 (United States); Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Athar, Mohammad, E-mail: mathar@uab.edu [Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294-0019 (United States); Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 (United States)

    2012-08-24

    Highlights: Black-Right-Pointing-Pointer p38 and Akt are the crucial molecular targets in the pathogenesis of SCCs in OTRs. Black-Right-Pointing-Pointer Combined inhibition of these targets diminished tumor growth by 90%. Black-Right-Pointing-Pointer Inhibition of these targets act through downregulating mTOR signaling pathway. -- Abstract: Non-melanoma skin cancers (NMSCs) are the most common neoplasm in organ transplant recipients (OTRs). These cancers are more invasive and metastatic as compared to those developed in normal cohorts. Previously, we have shown that immunosuppressive drug, cyclosporine A (CsA) directly alters tumor phenotype of cutaneous squamous cell carcinomas (SCCs) by activating TGF-{beta} and TAK1/TAB1 signaling pathways. Here, we identified novel molecular targets for the therapeutic intervention of these SCCs. We observed that combined blockade of Akt and p38 kinases-dependent signaling pathways in CsA-promoted human epidermoid carcinoma A431 xenograft tumors abrogated their growth by more than 90%. This diminution in tumor growth was accompanied by a significant decrease in proliferation and an increase in apoptosis. The residual tumors following the combined treatment with Akt inhibitor triciribine and p38 inhibitors SB-203580 showed significantly diminished expression of phosphorylated Akt and p38 and these tumors were less invasive and highly differentiated. Diminished tumor invasiveness was associated with the reduced epithelial-mesenchymal transition as ascertained by the enhanced E-cadherin and reduced vimentin and N-cadherin expression. Consistently, these tumors also manifested reduced MMP-2/9. The decreased p-Akt expression was accompanied by a significant reduction in p-mTOR. These data provide first important combinatorial pharmacological approach to block the pathogenesis of CsA-induced highly aggressive cutaneous neoplasm in OTRs.

  8. Oral delivery of Brucella spp. recombinant protein U-Omp16 abrogates the IgE-mediated milk allergy

    Science.gov (United States)

    Smaldini, Paola Lorena; Ibañez, Andrés Esteban; Fossati, Carlos Alberto; Cassataro, Juliana; Docena, Guillermo Horacio

    2014-01-01

    Food allergies are increasingly common disorders and no therapeutic strategies are yet approved. The unlipidated Omp16 (U-Omp16) is the outer membrane protein of 16 kDa from B. abortus and possesses a mucosal adjuvant property. In this study, we aimed to examine the U-Omp16 capacity to abrogate an allergen-specific Th2 immune response when it is administered as an oral adjuvant in a mouse model of food allergy.   Balb/c mice were sensitized with cholera toxin and cow’s milk proteins (CMP) by gavage and simultaneously treated with U-Omp16 and CMP. Oral challenge with CMP was performed to evaluate the allergic status of mice. Symptoms, local (small bowel cytokine and transcription factor gene expression) and systemic (specific isotypes and spleen cell-secreted cytokines) parameters, and skin tests were done to evaluate the immune response. We found that the oral administration of U-Omp16 with CMP during sensitization dampened the allergic symptoms, with negativization of immediate skin test and increased skin DTH response. Serum specific IgE and IL-5 were inhibited and a Th1 response was promoted (specific IgG2a antibodies and CMP-induced IFN-γ secretion). We found at the mucosal site an inhibition of the gene expression corresponding to IL-13 and Gata-3, with an induction of IFN-γ and T-bet. These results indicated that the oral administration of U-Omp16 significantly controlled the allergic response in sensitized mice with a shift of the balance of Th1- and Th2-T cells toward Th1 predominance. These findings suggest that U-Omp16 may be useful as a Th1-directing adjuvant in an oral vaccine. PMID:25424811

  9. Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs

    International Nuclear Information System (INIS)

    Highlights: ► p38 and Akt are the crucial molecular targets in the pathogenesis of SCCs in OTRs. ► Combined inhibition of these targets diminished tumor growth by 90%. ► Inhibition of these targets act through downregulating mTOR signaling pathway. -- Abstract: Non-melanoma skin cancers (NMSCs) are the most common neoplasm in organ transplant recipients (OTRs). These cancers are more invasive and metastatic as compared to those developed in normal cohorts. Previously, we have shown that immunosuppressive drug, cyclosporine A (CsA) directly alters tumor phenotype of cutaneous squamous cell carcinomas (SCCs) by activating TGF-β and TAK1/TAB1 signaling pathways. Here, we identified novel molecular targets for the therapeutic intervention of these SCCs. We observed that combined blockade of Akt and p38 kinases-dependent signaling pathways in CsA-promoted human epidermoid carcinoma A431 xenograft tumors abrogated their growth by more than 90%. This diminution in tumor growth was accompanied by a significant decrease in proliferation and an increase in apoptosis. The residual tumors following the combined treatment with Akt inhibitor triciribine and p38 inhibitors SB-203580 showed significantly diminished expression of phosphorylated Akt and p38 and these tumors were less invasive and highly differentiated. Diminished tumor invasiveness was associated with the reduced epithelial–mesenchymal transition as ascertained by the enhanced E-cadherin and reduced vimentin and N-cadherin expression. Consistently, these tumors also manifested reduced MMP-2/9. The decreased p-Akt expression was accompanied by a significant reduction in p-mTOR. These data provide first important combinatorial pharmacological approach to block the pathogenesis of CsA-induced highly aggressive cutaneous neoplasm in OTRs.

  10. A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells

    Science.gov (United States)

    Yigit, Burcu; Halibozek, Peter J.; Chen, Shih-Shih; O'Keeffe, Michael S.; Arnason, Jon; Avigan, David; Gattei, Valter; Bhan, Atul; Cen, Osman; Longnecker, Richard; Chiorazzi, Nicholas; Wang, Ninghai; Engel, Pablo; Terhorst, Cox

    2016-01-01

    The signaling lymphocyte activation molecule family [SLAMF] of cell surface receptors partakes in both the development of several immunocyte lineages and innate and adaptive immune responses in humans and mice. For instance, the homophilic molecule SLAMF6 (CD352) is in part involved in natural killer T cell development, but also modulates T follicular helper cell and germinal B cell interactions. Here we report that upon transplantation of a well-defined aggressive murine B220+CD5+ Chronic Lymphocytic Leukemia (CLL) cell clone, TCL1-192, into SCID mice one injection of a monoclonal antibody directed against SLAMF6 (αSlamf6) abrogates tumor progression in the spleen, bone marrow and blood. Similarly, progression of a murine B cell lymphoma, LMP2A/λMyc, was also eliminated by αSlamf6. But, surprisingly, αSLAMF6 neither eliminated TCL1-192 nor LMP2A/λMyc cells, which resided in the peritoneal cavity or omentum. This appeared to be dependent upon the tumor environment, which affected the frequency of sub-populations of the TCL1-192 clone or the inability of peritoneal macrophages to induce Antibody Dependent Cellular Cytotoxicity (ADCC). However, co-administering αSlamf6 with the Bruton tyrosine kinase (Btk) inhibitor, ibrutinib, synergized to efficiently eliminate the tumor cells in the spleen, bone marrow, liver and the peritoneal cavity. Because an anti-human SLAMF6 mAb efficiently killed human CLL cells in vitro and in vivo, we propose that a combination of αSlamf6 with ibrutinib should be considered as a novel therapeutic approach for CLL and other B cell tumors. PMID:27029059

  11. A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells.

    Science.gov (United States)

    Yigit, Burcu; Halibozek, Peter J; Chen, Shih-Shih; O'Keeffe, Michael S; Arnason, Jon; Avigan, David; Gattei, Valter; Bhan, Atul; Cen, Osman; Longnecker, Richard; Chiorazzi, Nicholas; Wang, Ninghai; Engel, Pablo; Terhorst, Cox

    2016-05-01

    The signaling lymphocyte activation molecule family [SLAMF] of cell surface receptors partakes in both the development of several immunocyte lineages and innate and adaptive immune responses in humans and mice. For instance, the homophilic molecule SLAMF6 (CD352) is in part involved in natural killer T cell development, but also modulates T follicular helper cell and germinal B cell interactions. Here we report that upon transplantation of a well-defined aggressive murine B220+CD5+ Chronic Lymphocytic Leukemia (CLL) cell clone, TCL1-192, into SCID mice one injection of a monoclonal antibody directed against SLAMF6 (αSlamf6) abrogates tumor progression in the spleen, bone marrow and blood. Similarly, progression of a murine B cell lymphoma, LMP2A/λMyc, was also eliminated by αSlamf6. But, surprisingly, αSLAMF6 neither eliminated TCL1-192 nor LMP2A/λMyc cells, which resided in the peritoneal cavity or omentum. This appeared to be dependent upon the tumor environment, which affected the frequency of sub-populations of the TCL1-192 clone or the inability of peritoneal macrophages to induce Antibody Dependent Cellular Cytotoxicity (ADCC). However, co-administering αSlamf6 with the Bruton tyrosine kinase (Btk) inhibitor, ibrutinib, synergized to efficiently eliminate the tumor cells in the spleen, bone marrow, liver and the peritoneal cavity. Because an anti-human SLAMF6 mAb efficiently killed human CLL cells in vitro and in vivo, we propose that a combination of αSlamf6 with ibrutinib should be considered as a novel therapeutic approach for CLL and other B cell tumors. PMID:27029059

  12. TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids

    OpenAIRE

    Doerner, Astrid M; Zuraw, Bruce L

    2009-01-01

    Background Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling are poorly understood, and there is increasing evidence that even aggressive anti-inflammatory therapy does not completely prevent this process. We sought to investigate whether TGFβ1 stimulates bronchial epithelial cells to undergo transition to a mesenchymal phenotype, and whether this transition can be abrogated by corticosteroid treatment o...

  13. Non-commutative Poisson Algebra Structures on the Lie Algebra son(CQ)

    Institute of Scientific and Technical Information of China (English)

    Jie Tong; Quanqin Jin

    2007-01-01

    Non-commutative Poisson algebras are the algebras having both an associativealgebra structure and a Lie algebra structure together with the Leibniz law.In this paper,the non-commutative poisson algebra structures on son(CQ) are determined.

  14. Fathers Are Important People: A Study of Father-Son Sexual Communication

    Science.gov (United States)

    DiIorio, Colleen; Lehr, Sally; Wasserman, Jill L.; Eichler, Michelle; Cherry, Chauncey; Denzmore, Pamela

    2006-01-01

    The purpose of this study was to examine the perceived role of African-American fathers in educating their sons about sex and HIV prevention. Given that some studies have shown a relationship between parent-adolescent sexual communication and adolescent sexual behavior, and the disproportionately high rates of teen pregnancy and HIV (and other…

  15. The risk of cryptorchidism among sons of women working in horticulture in Denmark

    DEFF Research Database (Denmark)

    Gabel, Pernille; Jensen, Morten Søndergaard; Andersen, Helle Raun;

    2011-01-01

    Androgens are crucial for normal testicular descent. Studies show that some pesticides have estrogenic or antiandrogenic effects, and that female workers exposed to pesticides have increased risk of having a boy with cryptorchidism. The main objective of the present study was to investigate whether...... pregnant women exposed to pesticides due to their work in horticulture experience excess risk of having sons with cryptorchidism....

  16. Men as caregivers of the elderly: support for the contributions of sons

    Directory of Open Access Journals (Sweden)

    Collins CR

    2014-11-01

    Full Text Available Cynthia R Collins Loyola University New Orleans, College of Social Sciences/School of Nursing, New Orleans, LA, USA Abstract: Emerging practice research on filial sources of health care support has indicated that there is a growing trend for sons to assume some responsibility for the health care needs of their aging parents. The purpose of this work is to propose that outcomes observed through a secondary analysis of data from a previous mixed methods research project, conducted with a sample of 60 elderly women residing in independent living centers, supports this concept in elder care. The present study is a retrospective interpretation utilizing the original database to examine the new question, “What specific roles do sons play in caregiving of their elderly mothers?” While daughters presently continue to emerge in existing health care studies as the primary care provider, there is a significant pattern in these data for older patients to depend upon sons for a variety of instrumental activities of daily living. As the baby-boomers age, there is more of cohort trend for their families to be smaller, adult daughters to be employed, and for adult children to be more geographically mobile. These factors may combine to make health care support networks more limited for the current aging population, challenging the elderly and their health care providers to revisit the cultural gender norms that are used to identify caregivers. Keywords: sons as caregivers, male caregivers, aging parents, filial support, informal caregivers 

  17. Charcot's son, commander Jean-Baptiste Charcot: from neurology to "Pourquoi Pas?"

    Directory of Open Access Journals (Sweden)

    Hélio A. G. Teive

    2012-04-01

    Full Text Available Charcot name became very famous around the world, firstly because of the work of Professor Jean-Martin Charcot, the founder of Clinical Neurology, and, secondly, because of his son, Jean-Baptiste, the world famous maritime explorer.

  18. Marriage Form and Son Preference in Rural China: An Investigation in Three Counties

    Science.gov (United States)

    Jin, Xiaoyi; Li, Shuzhuo; Feldman, Marcus W.

    2007-01-01

    Using data from two surveys in three counties among which the prevalence of uxorilocal marriage varies greatly, this paper analyzes effects of marriage form, as well as individual, family, and social factors on son preference in the context of strict birth control in rural China. It is shown that, under the Chinese patrilineal joint family system,…

  19. Better-surviving barn swallow mothers produce more and better-surviving sons.

    Science.gov (United States)

    Romano, Andrea; Costanzo, Alessandra; Caprioli, Manuela; Parolini, Marco; Ambrosini, Roberto; Rubolini, Diego; Saino, Nicola

    2016-05-01

    Sex allocation theory predicts that parents are selected to bias their progeny sex ratio (SR) toward the sex that will benefit the most from parental quality. Because parental quality may differentially affect survival of sons and daughters, a pivotal test of the adaptive value of SR adjustment is whether parents overproduce offspring of the sex that accrues larger fitness advantages from high parental quality. However, this crucial test of the long-term fitness consequences of sex allocation decisions has seldom been performed. In this study of the barn swallow (Hirundo rustica), we showed a positive correlation between the proportion of sons and maternal annual survival. We then experimentally demonstrated that this association did not depend on the differential costs of rearing offspring of either sex. Finally, we showed that maternal lifespan positively predicted lifespan of sons but not of daughters. Because in barn swallows lifespan is a strong determinant of lifetime reproductive success, the results suggest that mothers overproduce offspring of the sex that benefits the most from maternal quality. Hence, irrespective of mechanisms causing the SR bias and mother-son covariation in lifespan, we provide strong evidence that sex allocation decisions of mothers can highly impact on their lifetime fitness. PMID:26990898

  20. Evaluation of performance of Son Tek Argonaut acoustic doppler velocity log in tow tank and sea

    Digital Repository Service at National Institute of Oceanography (India)

    Joseph, A.; Madhan, R.; Mascarenhas, A.A.M.Q.; Desai; VijayKumar, K.; Dias, M.; Tengali, S.; Methar, A.

    of Performance of SonTek Argonaut Acoustic Doppler Velocity Log in Tow Tank and Sea Antony Joseph, R. Madhan, Antonio Mascaranhas, R.G. Prabhu Desai, Vijaykumar, Mathew Dias, Suryakant Tengali, and Anand Methar National Institute of Oceanography, Dona Paula...

  1. Terascale Physics Opportunities at a High Statistics, High Energy Neutrino Scattering Experiment: NuSOnG

    CERN Document Server

    Adams, T; Bugel, L; Camilleri, L; Conrad, J M; De Gouvêa, A; Fisher, P H; Formaggio, J A; Jenkins, J; Karagiorgi, G; Kobilarcik, T R; Kopp, S; Kyle, G; Loinaz, W A; Mason, D A; Milner, R; Moore, R; Morfín, J G; Nakamura, M; Naples, D; Nienaber, P; Olness, F I; Owens, J F; Pate, S F; Pronin, A; Seligman, W G; Shaevitz, M H; Schellman, H; Schienbein, I; Syphers, M J; Tait, T M P; Takeuchi, T; Tan, C Y; Van de Water, R G; Yamamoto, R K; Yu, J Y

    2008-01-01

    This article presents the physics case for a new high-energy, ultra-high statistics neutrino scattering experiment, NuSOnG (Neutrino Scattering on Glass). This experiment uses a Tevatron-based neutrino beam to obtain over an order of magnitude higher statistics than presently available for the purely weak processes $\

  2. Better-surviving barn swallow mothers produce more and better-surviving sons.

    Science.gov (United States)

    Romano, Andrea; Costanzo, Alessandra; Caprioli, Manuela; Parolini, Marco; Ambrosini, Roberto; Rubolini, Diego; Saino, Nicola

    2016-05-01

    Sex allocation theory predicts that parents are selected to bias their progeny sex ratio (SR) toward the sex that will benefit the most from parental quality. Because parental quality may differentially affect survival of sons and daughters, a pivotal test of the adaptive value of SR adjustment is whether parents overproduce offspring of the sex that accrues larger fitness advantages from high parental quality. However, this crucial test of the long-term fitness consequences of sex allocation decisions has seldom been performed. In this study of the barn swallow (Hirundo rustica), we showed a positive correlation between the proportion of sons and maternal annual survival. We then experimentally demonstrated that this association did not depend on the differential costs of rearing offspring of either sex. Finally, we showed that maternal lifespan positively predicted lifespan of sons but not of daughters. Because in barn swallows lifespan is a strong determinant of lifetime reproductive success, the results suggest that mothers overproduce offspring of the sex that benefits the most from maternal quality. Hence, irrespective of mechanisms causing the SR bias and mother-son covariation in lifespan, we provide strong evidence that sex allocation decisions of mothers can highly impact on their lifetime fitness.

  3. Does Father Know Best? Mothers and Fathers Teaching Their Preschool Sons and Daughters.

    Science.gov (United States)

    Frankel, Marc T.; And Others

    The interactional teaching patterns of 36 fathers and mothers with their 6-year-old sons and daughters were studied. Parents were asked to play (in parent-child dyads) with their child on a jigsaw puzzle and to teach the child to remember 25 picture cards that could be divided into conceptual categories. It was found that parents' instructional…

  4. Analysis of the Female Images in Sons and Lovers from the Feminist Perspective

    Institute of Scientific and Technical Information of China (English)

    付晓芳

    2015-01-01

    This thesis is an attempt to analyze the novel Sons and Lovers from the feminist perspective to expose women's suppressed and subordinate situation as “the other” in the patriarchal society, and to unmask the repression and predicament of immanent women.

  5. The Putative Son's Attractiveness Alters the Perceived Attractiveness of the Putative Father.

    Science.gov (United States)

    Prokop, Pavol

    2015-08-01

    A body of literature has investigated female mate choice in the pre-mating context (pre-mating sexual selection). Humans, however, are long-living mammals forming pair-bonds which sequentially produce offspring. Post-mating evaluations of a partner's attractiveness may thus significantly influence the reproductive success of men and women. I tested herein the theory that the attractiveness of putative sons provides extra information about the genetic quality of fathers, thereby influencing fathers' attractiveness across three studies. As predicted, facially attractive boys were more frequently attributed to attractive putative fathers and vice versa (Study 1). Furthermore, priming with an attractive putative son increased the attractiveness of the putative father with the reverse being true for unattractive putative sons. When putative fathers were presented as stepfathers, the effect of the boy's attractiveness on the stepfather's attractiveness was lower and less consistent (Study 2). This suggests that the presence of an attractive boy has the strongest effect on the perceived attractiveness of putative fathers rather than on non-fathers. The generalized effect of priming with beautiful non-human objects also exists, but its effect is much weaker compared with the effects of putative biological sons (Study 3). Overall, this study highlighted the importance of post-mating sexual selection in humans and suggests that the heritable attractive traits of men are also evaluated by females after mating and/or may be used by females in mate poaching. PMID:25731909

  6. Major ion chemistry of the Son River, India: Weathering processes, dissolved fluxes and water quality assessment

    Indian Academy of Sciences (India)

    Chinmaya Maharana; Sandeep Kumar Gautam; Abhay Kumar Singh; Jayanth K Tripathi

    2015-08-01

    River Son, draining diverse lithologies in the subtropical climate of the peninsular sub-basin of the Ganga basin, is one of the major tributaries of the Ganga River. The chemistry of major ions in the surface water of the Son River was studied in detail to determine various source(s) and processes controlling its water chemistry, seasonal and spatial variations in water chemistry, dissolved fluxes and chemical denudation rate (CDR). The study shows that Ca2+, Mg2+ and HCO$^{-}_{3}$ are major ionic species in the river water. Most of the measured parameters exhibit a relatively lower concentration in the post-monsoon as compared to pre-monsoon season. The water chemistry highlights the influence of continental weathering aided by secondary contributions from ground water, saline/alkaline soils and anthropogenic activities in the catchment. Results also reflect the dominance of carbonate weathering over silicate weathering in controlling water composition. The Son River delivers about 4.2 million tons of dissolved loads annually to the Ganga River, which accounts for ∼6% of the total annual load carried by the Ganga River to the Bay of Bengal. The average CDR of the Son River is 59.5 tons km−2 yr−1, which is less than the reported 72 tons km−2 yr−1 of the Ganga River and higher than the global average of 36 tons km−2 yr−1. The water chemistry for the pre-monsoon and post-monsoon periods shows a strong seasonal control on solute flux and CDR values. The water chemistry indicates that the Son River water is good to excellent in quality for irrigation and also suitable for drinking purposes.

  7. Los que son y no son: percorsi di identità (sonate nella Cuba della seconda metà del XIX secolo e inizi del XX

    Directory of Open Access Journals (Sweden)

    Irene Campagna

    2011-12-01

    Full Text Available The son is configured into the orbit of Cuban popular music as the mulatto music genre par excellence,  thanks to the amalgam of musical elements and structural features of Spanish and African origins.In its heyday - when are defined new modes of interpretation and new sonic possibilities - shares political and cultural unrest of vanguards that, through the recognition of the African component, try to build a coherent concept of nation, highlighting the contribution of black people to cultural and political processes. This work is based on the hypotheses suggested in some cuban studies recently published, about the causal relationship between the son’s development and the shape of national identity in the period of the Wars of Independence, to come to find through the  thematic analysis of representative texts the genre's functioning within this perspective.

  8. Možnost uporabe tekstilij za izkoriščanje sončne energije

    OpenAIRE

    Dretar, Nina

    2014-01-01

    Diplomsko delo obravnava možnost uporabe ploskih tekstilij v namene izkoriščanja sončne energije. V teoretičnem delu naloge so najprej predstavljene osnove sončnega sevanja, fotovoltaika, tj. veda, ki preučuje pretvorbo energije svetlobe v elektriko, ter zgradba in delovanje sončne celice. Osrednji del diplomskega dela se nanaša na stanje raziskav na področju uporabe tekstilij kot fotonapetostnih sistemov za izkoriščanje sončne energije. V nadaljevanju so predstavljeni načini izdelave tekstil...

  9. Instabilities of Spherical Solutions with Multiple Galileons and SO(N) Symmetry

    CERN Document Server

    Andrews, Melinda; Khoury, Justin; Trodden, Mark

    2010-01-01

    The 4-dimensional effective theory arising from an induced gravity action for a co-dimension greater than one brane consists of multiple galileon fields pi^I, I=1...N, invariant under separate Galilean transformations for each scalar, and under an internal SO(N) symmetry. We study the viability of such models by examining spherically symmetric solutions. We find that for general, non-derivative couplings to matter invariant under the internal symmetry, such solutions exist and exhibit a Vainshtein screening effect. By studying perturbations about such solutions, we find both an inevitable gradient instability and fluctuations propagating at superluminal speeds. These findings suggest that more general, derivative couplings to matter are required for the viability of SO(N) galileon theories.

  10. The deconfining phase transition of SO(N) gauge theories in 2+1 dimensions

    CERN Document Server

    Lau, Richard

    2015-01-01

    We calculate the deconfining temperature of SO(N) gauge theories in 2+1 dimensions, and determine the order of the phase transition as a function of N, for various values of N in the range [4,16]. We do so by extrapolating our lattice results to the infinite volume limit, and then to the continuum limit, for each value of N. We then extrapolate to the N=infinity limit and compare the SO(N) and SU(N) deconfining temperatures in that limit. We also compare the deconfining temperatures of SO(6) with SU(4), and of SO(4) with SU(2)xSU(2), motivated by the fact that these pairs of gauge theories share the same Lie algebras.

  11. L’eau à Damas et dans son environnement rural au xviiie siècle

    OpenAIRE

    Marino, Brigitte; Meier, Astrid

    2013-01-01

    Le système hydraulique qui alimente la ville de Damas et son environnement rural est très ancien. Mais il est en constante évolution et l’on peut difficilement accréditer l’idée de son caractère immuable. À partir de diverses sources juridiques, cet article s’interroge sur les règles, les pratiques et les procédures administratives et juridiques qui sont en vigueur dans le domaine de la distribution de l’eau à Damas et dans sa campagne au xviiie siècle. Il montre le rôle des autorités juridiq...

  12. Patterns of Parental Spending: Do Parents Spend More Money on Sons or Daughters?

    OpenAIRE

    Batten, George P

    2013-01-01

    This study examines the spending patterns of parents, indentifying differences in the amount of money that parents spend on select items for sons compared to daughters. Using secondary data from the "Consumer Expenditure Survey: Diary Survey" dataset from 2008 through 2010, this study tests the hypothesis that parents with adolescent girls spend more money on apparel, beauty and hygiene products, health care, and education compared to parents with adolescent boys. An interaction effect for ge...

  13. Living with foster siblings: the adjustment of adolescent sons and daughters in families who foster.

    OpenAIRE

    Richardson, J.

    2007-01-01

    This paper aims to review how fostering affects the adjustment of adolescent sons and daughters in families who foster. The research is presented within a developmental psychopathology framework, addressing individual, parent-child and sibling factors that affect adolescents' adjustment. These factors are initially discussed in the context of 'normative' families and stepfamilies, as a prelude for understanding the adjustment of adolescents in reconstituted foster families. Secondly, fifteen ...

  14. The mystery of the perpetual motion clock of Geiser and Son

    Science.gov (United States)

    Piguet, Jean-Michel

    A description of the operation and mechanisms of a so called perpetual motion clock is given. At the end of the 18th and beginning of the 19th century, the achievement of perpetual motion was one of the Neuchatel clockmakers' great interests. Some watchmakers presented scientists and the public with constructions which, at first sight, seemed to have solved the problem. In 1815 a really interesting clock mechanism invented by Jean Geiser and his son was presented in Neuchatel.

  15. Pragmatic Analysis of a Dialogue in Laurence’s Sons and Lovers

    Institute of Scientific and Technical Information of China (English)

    李桂芝; 马宏

    2008-01-01

    This article provides a pragmatic analysis of a dialogue in Laurence’s Sons and Lovers from the perspectives of turn-taking,cooperative principle,politeness principle and speech act theory. A detailed analysis shows that pragmatic theories provide a good approach to the appreciation of fiction and that such kind of analysis based on a relatively precise methodology proves to be an effective approach to capture the richness of characters.

  16. Integrating Equality - Globalization, Women’s Rights, Son Preference and Human Trafficking

    OpenAIRE

    Cho, Seo-Young

    2011-01-01

    Employing economic and social globalization indicators, we empirically analyze whether globalization affects women’s rights in the economic and social dimensions. Using panel data from 150 countries over the 1981-2008 period, we find that social globalization positively affects both women’s economic and social rights, while the impact of economic globalization disappears when controlling for social globalization. Furthermore, we find that social globalization also reduces ‘son preference’ pro...

  17. Complicity to Hegemonic Masculinity in D.H. Lawrence’s Sons and Lovers

    OpenAIRE

    Angelina Subrayan; Wan Roselezam Wan Yahya

    2016-01-01

    Men have long been associated with dominance, strength and confidence and the issue regarding being compliant to the acceptable masculine ideal has always been part of a culture’s social identity. This study focuses on the critical discussion on masculinity studies in the classic fiction of D.H Lawrence.  Drawing on narrative data from his novel Sons and Lovers (1913), the study examines how hegemonic masculinity is conformed by the male protagonist, Walter Morel, in his gendered relationship...

  18. Girl adoption in China-A less-known side of son preference.

    Science.gov (United States)

    Chen, Yuyu; Ebenstein, Avraham; Edlund, Lena; Li, Hongbin

    2015-01-01

    In 1987, 4 per cent of girls were adopted within China. Why? Unlike infanticide, abandonment rids parents of daughters while preserving the supply of potential brides. In fact, an erstwhile tradition common in Fujian and Jiangxi provinces had parents of sons adopting an infant girl to serve as a future daughter-in-law and household help. Analysing a nationally representative 1992 survey of children, we found that: (1) girl adoptions were concentrated in the above-mentioned provinces; (2) girls were predominantly adopted by families with sons; (3) adopted girls faced substantial disadvantage as measured by school attendance at ages 8-13. In the 1990s, as the sex ratio at birth climbed, were girls aborted rather than abandoned? Observing that in the 2000 census too many girls appear in families with older sons, we estimated that at least 1/25 girls were abandoned in the 1990s, a proportion that in Fujian and Jiangxi may have peaked at 1/10 in 1994. PMID:25789605

  19. Mutation rate at 17 Y-STR loci in "Father/Son" pairs from moroccan population.

    Science.gov (United States)

    Laouina, Adil; Nadifi, Sellama; Boulouiz, Redouane; El Arji, Marzouk; Talbi, Jalal; El Houate, Brahim; Yahia, Hakima; Chbel, Faiza

    2013-09-01

    Precise knowledge of mutation rate at Y-STRs loci is essential for a correct evaluation of typing results in forensic casework and specially kinship genetic studies. In this study, we have examined 252 confirmed and unrelated father/son sample pairs from Moroccan population using the 17 Y-STR markers DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, and Y-GATA-H4 of the AmpFlSTR Yfiler™ kit used in routine casework. We observed a total of 15 single repeat mutations between fathers and sons as mutational events. Nine mutations resulted in the gain of a repeat in the son and six resulted in a loss of a repeat. The average mutation rate in the studied sample is 3.5×10(-3) (95% CI 2-5.8×10(-3)). Furthermore, Y-STRs mutation occurrence seems to be 4 times more frequent than autosomal STRs mutation in this sample. PMID:23623014

  20. Multivariate Multiple Regression Models for a Big Data-Empowered SON Framework in Mobile Wireless Networks

    Directory of Open Access Journals (Sweden)

    Yoonsu Shin

    2016-01-01

    Full Text Available In the 5G era, the operational cost of mobile wireless networks will significantly increase. Further, massive network capacity and zero latency will be needed because everything will be connected to mobile networks. Thus, self-organizing networks (SON are needed, which expedite automatic operation of mobile wireless networks, but have challenges to satisfy the 5G requirements. Therefore, researchers have proposed a framework to empower SON using big data. The recent framework of a big data-empowered SON analyzes the relationship between key performance indicators (KPIs and related network parameters (NPs using machine-learning tools, and it develops regression models using a Gaussian process with those parameters. The problem, however, is that the methods of finding the NPs related to the KPIs differ individually. Moreover, the Gaussian process regression model cannot determine the relationship between a KPI and its various related NPs. In this paper, to solve these problems, we proposed multivariate multiple regression models to determine the relationship between various KPIs and NPs. If we assume one KPI and multiple NPs as one set, the proposed models help us process multiple sets at one time. Also, we can find out whether some KPIs are conflicting or not. We implement the proposed models using MapReduce.

  1. Son Preference and Family Planning Practices among Married Men in Mumbai, India

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective To study son preferences and the contraceptive knowledge, attitude and practices of Indian Male Subjects & Methods The data was obtained through a semi-structured interview schedule caried out in 2 687 married men at Mumbai City, India in 1999.Results About 80% of men felt two children as their ideal family size, while 82%desired two children i.e. one son and one daughter. 8. 2% of men had strong prefer ence for two or more sons because of family lineage, old age support and to support each other.23. 1% of the couples had used contraceptives in the past, 48% of couples were not using any contraceptive method at the time of survey. Male participation in spacing contraceptive methods was 23% i.e. condom 21.9% and withdrawal 1.1%. Though awareness (99. 9% ) and knowledge (95. 2% ) of condom was high, only 42. 8% of subjects knew use the correct of the method. Only 2. 4% of them thought about accept ing vasectomy, while others reported various misconception.Conclusion This study suggests a pressing need for effective intervention strategies,both at the community level and the clinic level, backed with efficient motivation, coun seling and provision of quality services in urban areas.

  2. Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes.

    Science.gov (United States)

    Mitkevich, Vladimir A; Petrushanko, Irina Y; Spirin, Pavel V; Fedorova, Tatiana V; Kretova, Olga V; Tchurikov, Nickolai A; Prassolov, Vladimir S; Ilinskaya, Olga N; Makarov, Alexander A

    2011-12-01

    Some RNases selectively attack malignant cells, triggering an apoptotic response, and therefore are considered as alternative chemotherapeutic drugs. Here we studied the effects of Bacillus intermedius RNase (binase) on murine myeloid progenitor cells FDC-P1; transduced FDC-P1 cells ectopically expressing mutated human KIT N822K oncogene and/or human AML1-ETO oncogene; and human leukemia Kasumi-1 cells expressing both of these oncogenes. Expression of both KIT and AML1-ETO oncogenes makes FDC-P1 cells sensitive to the toxic effects of binase. Kasumi-1 cells were the most responsive to the toxic actions of binase among the cell lines used in this work with an IC50 value of 0.56 µM. Either blocking the functional activity of the KIT protein with imatinib or knocking-down oncogene expression using lentiviral vectors producing shRNA against AML1-ETO or KIT eliminated the sensitivity of Kasumi-1 cells to binase toxic action and promoted their survival, even in the absence of KIT-dependent proliferation and antiapoptotic pathways. Here we provide evidence that the cooperative effect of the expression of mutated KIT and AML1-ETO oncogenes is crucial for selective toxic action of binase on malignant cells. These findings can facilitate clinical applications of binase providing a useful screen based on the presence of the corresponding target oncogenes in malignant cells.

  3. The Impact of Birth Order on Intergenerational Transmission of Attitudes from Parents to Adolescent Sons: The Israeli Case

    Science.gov (United States)

    Kulik, Liat

    2004-01-01

    This study deals with birth order and its impact on intergenerational transmission of parental attitudes to adolescent sons in Israeli society. The sample included 294 participants (including 98 mothers, 98 fathers, and 98 sons). The attitudes chosen were key issues of concern in Israeli society: gender role attitudes, ethnic stereotypes, and…

  4. Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia

    Science.gov (United States)

    Huang, Sai; Jiang, Meng-Meng; Chen, Guo-Feng; Qian, Kun; Gao, Hong-Hao; Guan, Wei; Shi, Jin-Long; Liu, An-Qi; Liu, Jing; Wang, Bian-Hong; Li, Yong-Hui; Yu, Li

    2016-01-01

    Background: The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;21)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML. By focusing on the anti-leukemia effects of eyes absent 4 (EYA4) gene on AML cells, we investigated the biologic and molecular mechanism associated with AML1-ETO expressed in t(8;21) AML. Methods: Qualitative polymerase chain reaction (PCR), quantitative reverse transcription PCR (RT-PCR), and Western blotting analysis were used to observe the mRNA and protein expression levels of EYA4 in cell lines. Different plasmids (including mutant plasmids) of dual luciferase reporter vector were built to study the binding status of AML1-ETO to the promoter region of EYA4. Chromatin immunoprecipitation assay was used to study the epigenetic silencing mechanism of EYA4. Bisulfite sequencing was applied to detect the methylation status in EYA4 promoter region. The influence of EYA4 gene in the cell proliferation, apoptosis, and cell clone-forming ability was detected by the technique of Cell Counting Kit-8, flow cytometry, and clonogenic assay. Results: EYA4 gene was hypermethylated in AML1-ETO+ patients and its expression was down-regulated by 6-fold in Kasumi-1 and SKNO-1 cells, compared to HL-60 and SKNO-1-siA/E cells, respectively. We demonstrated that AML1-ETO triggered the epigenetic silencing of EYA4 gene by binding at AML1-binding sites and recruiting histone deacetylase 1 and DNA methyltransferases. Enhanced EYA4 expression levels inhibited cellular proliferation and suppressed cell colony formation in AML1-ETO+ cell lines. We also found EYA4 transfection increased apoptosis of Kasumi-1 and SKNO-1 cells by 1.6-fold and 1.4-fold compared to negative control, respectively. Conclusions: Our study identified EYA4 gene as targets for AML1-ETO and indicated it as a novel tumor suppressor gene. In addition, we provided evidence that EYA4 gene might be a novel therapeutic target

  5. Epigenetic Silencing of Eyes Absent 4 Gene by Acute Myeloid Leukemia 1-Eight-twenty-one Oncoprotein Contributes to Leukemogenesis in t(8;21) Acute Myeloid Leukemia

    Institute of Scientific and Technical Information of China (English)

    Sai Huang; Meng-Meng Jiang; Guo-Feng Chen; Kun Qian; Hong-Hao Gao; Wei Guan; Jin-Long Shi

    2016-01-01

    Background:The acute myeloid leukemia 1 (AML 1)-eight-twenty-one (ETO) fusion protein generated by the t(8;21)(q22;q22) translocation is considered to display a crucial role in leukemogenesis in AML.By focusing on the anti-leukemia effects of eyes absent 4 (EYA4) gene on AML cells,we investigated the biologic and molecular mechanism associated with AML1-ETO expressed in t(8;21) AML.Methods:Qualitative polymerase chain reaction (PCR),quantitative reverse transcription PCR (RT-PCR),and Western blotting analysis were used to observe the mRNA and protein expression levels of EYA4 in cell lines.Different plasmids (including mutant plasmids) of dual luciferase reporter vector were built to study the binding status of AML1-ETO to the promoter region of EYA4.Chromatin immunoprecipitation assay was used to study the epigenetic silencing mechanism of EYA4.Bisulfite sequencing was applied to detect the methylation status in EYA4 promoter region.The influence of EYA4 gene in the cell proliferation,apoptosis,and cell clone-forming ability was detected by the technique of Cell Counting Kit-8,flow cytometry,and clonogenic assay.Results:EYA4 gene was hypermethylated in AML1-ETO+ patients and its expression was down-regulated by 6-fold in Kasumi-1 and SKNO-1 cells,compared to HL-60 and SKNO-1-siA/E cells,respectively.We demonstrated that AML1-ETO triggered the epigenetic silencing of EYA4 gene by binding at AML1-binding sites and recruiting histone deacetylase 1 and DNA methyltransferases.Enhanced EYA4 expression levels inhibited cellular proliferation and suppressed cell colony formation in AML1-ETO+ cell lines.We also found EYA4 transfection increased apoptosis ofKasumi-1 and SKNO-1 cells by 1.6-fold and 1.4-fold compared to negative control,respectively.Conclusions:Our study identified EYA4 gene as targets for AML1-ETO and indicated it as a novel tumor suppressor gene.In addition,we provided evidence that EYA4 gene might be a novel therapeutic target and a potential candidate

  6. ¿Son fiables los productos que encontramos en los supermercados?

    OpenAIRE

    Olivares Zabalandicoechea, Maitane; Zuloaga Zubieta, Olatz

    2012-01-01

    Duración (en horas): De 21 a 30 horas. Destinatario: Estudiante En este recurso didáctico se presenta la metodología en base a proyectos utilizada en el proceso de enseñanza-aprendizaje de la asignatura optativa "Cromatografía y Técnicas Afines" que se imparte en el segundo ciclo de la Licenciatura de Química. El proyecto, que lleva como título "¿Son fiables los productos que encontramos en los supermercados?", permite al alumno aprender los distintos métodos analíticos para el a...

  7. The Tragedy of Hamlet, Son of an Organic Chemist of Denmark

    Science.gov (United States)

    Brisbois, Ronald G.

    2004-04-01

    Once faced with structure reactivity relationships in the context of nucleophilic substitution at sp 3 carbon, introductory organic chemistry students must compare and contrast the various attributes and ramifications of S N 2 versus S N 1 reaction pathways. The dramatic (even melodramatic) way in which some students ask such comparative questions inspired a parody of Hamlet's famous to be or not to be soliloquy. Herein, Hamlet (the son of an organic chemist of Denmark) is the surrogate of any and every student as he uses a thoroughly Shakespearian approach to sorting out some of the key distinguishing features of S N 2 versus S N 1 reactions.

  8. Healing of the royal official’s son in John 4:46-54

    Directory of Open Access Journals (Sweden)

    Jan Van der Watt

    2012-01-01

    Full Text Available The healing of the royal official’s son (4:46-54 is one of the neglected sections in John’s Gospel. Although it is considered in commentaries and it is often used in sermons it is rarely the subject of wider discussion. This article considers the narratological, social and historical aspects of this brief miracle narrative. The complex structure of the narrative is considered, its relation to parallels in the Synoptics and possible shared sources are investigated, and possibilities for understanding the narrative are discussed.

  9. Performance of the Birmingham Solar-Oscillations Network (BiSON)

    CERN Document Server

    Hale, S J; Chaplin, W J; Davies, G R; Elsworth, Y P

    2015-01-01

    The Birmingham Solar-Oscillations Network (BiSON) has been operating with a full complement of six stations since 1992. Over 20 years later, we look back on the network history. The meta-data from the sites have been analysed to assess performance in terms of site insolation, with a brief look at the challenges that have been encountered over the years. We explain how the international community can gain easy access to the ever-growing dataset produced by the network, and finally look to the future of the network and the potential impact of nearly 25 years of technology miniaturisation.

  10. L'entrepreneuriat immigré et son accompagnement en France,

    OpenAIRE

    Levy-Tadjine, Thierry

    2004-01-01

    Partant du constat que la littérature anglo-saxonne sur l'entrepreneuriat ethnique et immigré est insatisfaisante pour rendre compte du phénomène entrepreneurial immigré dans le contexte français et de son accompagnement, nous proposons un modèle dialectique et téléologique de l'Entrepreneuriat Immigré fondé sur la Psycho-Sociologie de l'Interculturel et sur la Théorie des conventions. Ce modèle rend compte de la diversité des trajectoires entrepreneuriales des publics issus de l'immigration....

  11. Autismo y Programa Son-Rise: Intervención sobre un caso

    OpenAIRE

    López Camarero, Irene

    2013-01-01

    En este documento se estudian los distintos tipos de trastorno del espectro autista, distinguiendo las características de cada uno de ellos y las posibles causas que pueden originarlos. Partiendo de esta base, se plantean distintos métodos o programas existentes en nuestra sociedad para trabajar con este colectivo y lograr que desarrollen sus capacidades en el máximo nivel posible. Tras una breve explicación de algunos de ellos, nos centramos en el Programa Son-Rise, método poco conocid...

  12. The risk of cryptorchidism among sons of women working in horticulture in Denmark: a cohort study

    Directory of Open Access Journals (Sweden)

    Gabel Pernille

    2011-11-01

    Full Text Available Abstract Background Androgens are crucial for normal testicular descent. Studies show that some pesticides have estrogenic or antiandrogenic effects, and that female workers exposed to pesticides have increased risk of having a boy with cryptorchidism. The main objective of the present study was to investigate whether pregnant women exposed to pesticides due to their work in horticulture experience excess risk of having sons with cryptorchidism. Methods We conducted a cohort study of pregnant women working in horticulture using four cohorts including one cohort established with data from the departments of occupational medicine in Jutland and Funen and three existing mother-child cohorts (n = 1,468. A reference group was established from the entire Danish population of boys born in the period of 1986-2007 (n = 783,817. Nationwide Danish health registers provided information on birth outcome, cryptorchidism diagnosis and orchiopexy. The level of occupational exposure to pesticides was assessed by expert judgment blinded towards outcome status. Risk of cryptorchidism among exposed horticulture workers compared to the background population and to unexposed horticulture workers was assessed by Cox regression models. Results Pesticide exposed women employed in horticulture had a hazard ratio (HR of having cryptorchid sons of 1.39 (95% CI 0.84; 2.31 and a HR of orchiopexy of 1.34 (0.72; 2.49 compared to the background population. Analysis divided into separate cohorts revealed a significantly increased risk of cryptorchidism in cohort 2: HR 2.58 (1.07;6.20 and increased risk of orchiopexy in cohort 4: HR 2.76 (1.03;7.35, but no significant associations in the other cohorts. Compared to unexposed women working in horticulture, pesticide exposed women had a risk of having sons with cryptorchidism of 1.34 (0.30; 5.96 and of orchiopexy of 1.93 (0.24;15.4. Conclusions The data are compatible with a slightly increased risk of cryptorchidism in sons of women

  13. Lowest-energy states in parity-transformation eigenspaces of SO(N) spin chain

    OpenAIRE

    Tigran Hakobyan

    2015-01-01

    We expand the symmetry of the open finite-size SO(N) symmetric spin chain to O(N). We partition its space of states into the eigenspaces of the parity transformations in the flavor space, generating the subgroup $Z_2^{\\times(N-1)}$. It is proven that the lowest-energy states in these eigenspaces are nondegenerate and assemble in antisymmetric tensors or pseudotensors. At the valence-bond solid point, they constitute the $2^{N-1}$-fold degenerate ground state with fully broken parity-transform...

  14. Were king Stefan the First-Crowned and his son Radoslav co-rulers?

    OpenAIRE

    Bubalo Đorđe

    2009-01-01

    The Serbian historiography considers the issue of the co-ruling of King Stefan the First-Crowned and his son Radoslav as the one finally resolved. The suggested solution on the co-rule of Stefan and Radoslav may be most succinctly expressed as following: as early as in the year of 1220, due to the frail health of Stefan the First-Crowned and Radoslav's marriage to Anne the Epirus princess, Radoslav was crowned to be the king and positioned to co-rule with his father after the Byzantine model ...

  15. Deformations of fundamental group representations and earthquakes on $SO(n,1)$ surface groups

    OpenAIRE

    Ho, Son Lam

    2016-01-01

    In this article we construct a type of deformations of representations $\\pi_1(M)\\rightarrow G$ where $G$ is an arbitrary lie group and $M$ is a large class of manifolds including CAT(0) manifolds. The deformations are defined based on codimension 1 hypersurfaces with certain conditions, and also on disjoint union of such hypersurfaces, i.e. multi-hypersurfaces. We show commutativity of deforming along disjoint hypersurfaces. As application, we consider Anosov surface groups in $SO(n,1)$ and s...

  16. The $1/N$ expansion for $SO(N)$ lattice gauge theory at strong coupling

    CERN Document Server

    Chatterjee, Sourav

    2016-01-01

    The $1/N$ expansion is an asymptotic series expansion for certain quantities in large-$N$ lattice gauge theories. This article gives a rigorous formulation and proof of the $1/N$ expansion for Wilson loop expectations in $SO(N)$ lattice gauge theory in the strong coupling regime in any dimension. The terms in the expansion are expressed as sums over trajectories of strings in a lattice string theory, establishing an explicit gauge-string duality. The trajectories trace out surfaces of genus zero for the first term in the expansion, and surfaces of higher genus for the higher terms.

  17. CHIRAL RING OF Sp(N) AND SO(N) SUPERSYMMETRIC GAUGE THEORY IN FOUR DIMENSIONS

    Institute of Scientific and Technical Information of China (English)

    E. WITTEN

    2003-01-01

    The chiral ring of classical supersymmetric Yang-Mills theory with gauge group Sp(N) or SO(N) is computed, extending previous work (of Cachazo, Douglas, Seiberg, and the author)for SU(N). The result is that, as has been conjectured, the ring is generated by the usualglueball superfield S ~ Tr WαWα, with the relation Sh = 0, h being the dual Coxeter number.Though this proposition has important implications for the behavior of the quantum theory,the statement and (for the most part) the proofs amount to assertions about Lie groups withno direct reference to gauge theory.

  18. Self-Organizing Networks (SON) Self-Planning, Self-Optimization and Self-Healing for GSM, UMTS and LTE

    CERN Document Server

    Ramiro, Juan

    2011-01-01

    With the current explosion in network traffic, and mounting pressure on operators' business case, Self-Organizing Networks (SON) play a crucial role. They are conceived to minimize human intervention in engineering processes and at the same time improve system performance to maximize Return-on-Investment (ROI) and secure customer loyalty. Written by leading experts in the planning and optimization of Multi-Technology and Multi-Vendor wireless networks, this book describes the architecture of Multi-Technology SON for GSM, UMTS and LTE, along with the enabling technologies for SON planning, opti

  19. Étude de son 3D pour une interaction audio-visuelle en environnement virtuel enrichi

    OpenAIRE

    Ortega González, Erik Vladimir

    2011-01-01

    La plupart des applications qui intègrent le son 3D en environnement virtuel sont limitées à la simulation acoustique. L'objectif de cette thèse est d'étudier l'apport du son 3D dans l'interaction en environnement virtuel. Nous avons développé une technique de stimulation sonore appelée: Sensation Artificielle Spatialisée Auditive (SASA), basée sur la création d'effets sonores. Cette technique restitue des sensations de spatialisation de son permettant la localisation précise (en azimut et en...

  20. Seismic Interpretation of the Nam Con Son Basin and its Implication for the Tectonic Evolution

    Directory of Open Access Journals (Sweden)

    Nguyen Quang Tuan

    2016-08-01

    Full Text Available The Nam Con Son Basin covering an area of circa 110,000 km2 is characterized by complex tectonic settings of the basin which has not fully been understood. Multiple faults allowed favourable migration passageways for hydrocarbons to go in and out of traps. Despite a large amount of newly acquired seismic and well data there is no significant update on the tectonic evolution and history of the basin development. In this study, the vast amount of seismic and well data were integrated and reinterpreted to define the key structural events in the Nam Con Son Basin. The results show that the basin has undergone two extentional phases. The first N - S extensional phase terminated at around 30 M.a. forming E - W trending grabens which are complicated by multiple half grabens filled by Lower Oligocene sediments. These grabens were reactivated during the second NW - SE extension (Middle Miocene, that resulted from the progressive propagation of NE-SW listric fault from the middle part of the grabens to the margins, and the large scale building up of roll-over structure. Further to the SW, the faults of the second extentional phase turn to NNE-SSW and ultimately N - S in the SW edge of the basin. Most of the fault systems were inactive by Upper Miocene except for the N - S fault system which is still active until recent time.

  1. Léon Bardalès: Sa vie et son œuvre

    Directory of Open Access Journals (Sweden)

    Ilias Taxidis

    2011-07-01

    Full Text Available Cette étude comprend la présentation et l’édition critique de deux lettres et six poèmes de Léon Bardalès qui fut l’un des dignitaires impériaux byzantins de la fin du XIIIe et du début du XIVe siècle. Pour l’occasion, toutes les données concernant l’auteur et son activité politique et littéraire sont réévaluées conformément aux informations fournies par les lettres que Bardalès a reçues d’épistoliers connus de son époque, comme Maxime Planude, Nicéphore Choumnos et Nicéphore Grégoras. Dans l’édition, les erreurs et fautes d’inattention des éditeurs précédents sont corrigées, et un apparat des sources est ajouté.

  2. Symbolism of the Shadows in Son of Man by Roa Bastos

    Institute of Scientific and Technical Information of China (English)

    Patricia G. Montenegro

    2015-01-01

    In his novel Son of Man, Augusto Roa Bastos uses images and symbols of shadows to represent the ramifications ofthe Paraguayan Dr. Jose Rodriguez de Francia's dictatorship. Rodriguez de Francia's legacy, which begins duringthe postcolonial years and extends well into the 20th century, resonates in the novel in soeio-political structures andcharacters' ideologies and behaviors. It allows for plantation owners to enslave workers and their families; itconfines and oppresses people through unfounded legends and myths; and among other things, it creates a falseidea of purpose and patriotism in the Chaco War (1932-1935), which in the end lets down the soldiers. Tocounteract these deleterious social conditions, Roa Bastos creates surreal characters, such as a fantastic helper whoaids plantation workers to escape dehumanizing situations. Roa Bastos also narrates how the people in Itapr, asmall town, make an idol of a Christ statue carved by one of their own. However, when the two Goiburfl brothersreplace the statue by crucifying their sister's rapist, the people's myth is destroyed. Likewise, Roa Bastos availshimself of Christian and Catholic concepts and symbols to transpose them into a humanistic ideology so as toconvey hope to his people through a new perspective. In this way, a new Annunciation takes place when the son ofa raped woman is born. In the end, Roa Bastos lets the course of these warped transpositions take their logicaldenouement: In the absence of a purpose beyond an earthly existence, death becomes the narrator's option.

  3. On the N-dependence of SO(N) and SU(N) gauge theories in 2+1 dimensions

    CERN Document Server

    Athenodorou, Andreas; Teper, Michael

    2015-01-01

    We compare (continuum) mass ratios of the lightest `glueballs' as a function of N for SO(N) and SU(N) lattice gauge theories in D=2+1. We observe that the leading large N correction is usually sufficient to describe the N-dependence both of SO(N) for N greater than or equal to 3, and of SU(N) for N greater than or equal to 2. Moreover the coefficient of this correction is found to be remarkably small in both cases. We point out that this can follow naturally from the strong constraints that one naively expects from the Lie algebra equivalence between certain SO(N) and SU(N') theories. The same argument for a weak N-dependence can apply to SU(N) and SO(N) gauge theories in D=3+1.

  4. The Psychoanalytic Study of the Personality Development of Paul Morel in D.H.Lawrence‘s Novel Sons and Lovers

    OpenAIRE

    Zaira Wahab; Shumaila Mazhar; Fozia Sultana

    2012-01-01

    We investigate D. H. Lawrence’s delineation of Paul’s personality development and its harmony with Freudian concept in the novel Sons and Lovers. The study has approached the novel from psychological perspective particularly emphasizing Freudian Theory of Psychosexual Development. The qualitative research paradigm is adopted focusing on textual data analysis of the novel Sons and Lovers. The findings of the study revealed how Paul’s early childhood trauma caused by his father’s brutal treatme...

  5. L’emploi industriel en France et son évolution 1994-2004

    Directory of Open Access Journals (Sweden)

    Régis Guillaume

    2008-07-01

    Full Text Available Le déclin de l’emploi industriel est souvent appréhendé comme le symbole des difficultés de la France à maintenir son rang dans une économie toujours plus mondialisée et plus concurrentielle. L’article vise, à partir des statistiques de l’emploi, à montrer que la diminution des effectifs est loin d’être homogène et que, depuis une dizaine d’années, elle s’accompagne d’un redéploiement géographique de forte intensité. On a construit à cet effet des agrégats spécifiques permettant de prendre en compte le devenir des filières productives majeures.

  6. Deconfining temperatures in SO(N) and SU(N) gauge theories

    CERN Document Server

    Lau, Richard

    2015-01-01

    We present our current results for the deconfining temperatures in SO(N) gauge theories in 2+1 dimensions. SO(2N) theories may help us to understand QCD at finite chemical potential since there is a large-N orbifold equivalence between SO(2N) QCD-like theories and SU(N) QCD, and SO(2N) theories do not have the sign problem present in QCD. We show that the deconfining temperatures in these two theories match at the large-N limit. We also present results for SO(2N+1) gauge theories and compare results for SO(6) with SU(4) gauge theories, which have the same Lie algebras but different centres.

  7. Pincio y los Estados Unidos que no son los Estados Unidos

    Directory of Open Access Journals (Sweden)

    Franco Zangrilli

    2015-07-01

    Full Text Available Lo neofantástico en Tommaso Pincio se distingue de lo fantástico posmoderno de nuestros escritores. Se basa en la realidad estadounidense contemporánea; la introduce en un proceso de elaboraciones enfáticas, mezclas, transfiguraciones, y la convierte en el símbolo de otro mundo, de un planeta extraño. Pincio llega a esta operación creativa gracias a su conocimiento de las tradiciones y de las costumbres, de la historia, de la cultura y de la literatura de los Estados Unidos. De todo eso quiere darse una idea en este ensayo, analizando la segunda novela de Pincio, Spazio sfinito, en la que se representa a unos Estados Unidos que no son Estados Unidos.

  8. La linguistique marriste et son onomastique. Le cas de la Géorgie

    OpenAIRE

    Van Elverdinghe, Emmanuel

    2014-01-01

    Les théories linguistiques de Nikolaj Marr ont profondément imprégné la vie intellectuelle soviétique jusque dans les années 1950. Ce succès s’explique à la fois par une série de facteurs conjoncturels et par la personnalité même du savant géorgien. En plus d’une chronologie périodisée de l’évolution du « marrisme », il est possible de distinguer des fils de trame invariants, qui depuis ses débuts sous-tendent son développement. L’étude des ethnonymes et des toponymes constituait pour Marr un...

  9. The death of a young son in violent circumstance: understanding the experience of the mother.

    Science.gov (United States)

    Alarcão, Ana Carolina Jacinto; Carvalho, Maria Dalva de Barros; Pelloso, Sandra Marisa

    2008-01-01

    This study was aimed at understanding the life of a mother who lost their child in violent circumstances. The methodological proceedings were supported on phenomenology. The study population was constituted by five mothers who had lost its young children for homicide. These homicides occurred different times ranging from 50 days to 10 years. I used as instrument of collection of data open interview the phenomenological method guided by a orienting question. The analysis phenomenology in their discourses showed the comprehension of essential meanings which were systematized in categories: the child's mummification in the memory; the two ways followed by the publicity concerning the death; fondness to spirituality to endure the pain from the child's death; maternal complicity and impunity. The results of this study can contribute to elaboration of intervention proposals close to the mothers in the sense of helping them in the reorganization of their lives after son's death. PMID:18695804

  10. Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma.

    Science.gov (United States)

    Chua, Kian Ngiap; Kong, Li Ren; Sim, Wen Jing; Ng, Hsien Chun; Ong, Weijie Richard; Thiery, Jean Paul; Huynh, Hung; Goh, Boon Cher

    2015-10-01

    Oncogenesis in non-small cell lung cancer (NSCLC) is regulated by a complex signal transduction network. Single-agent targeted therapy fails frequently due to treatment insensitivity and acquired resistance. In this study, we demonstrate that co-inhibition of the MAPK and SRC pathways using a PD0325901 and Saracatinib kinase inhibitor combination can abrogate tumor growth in NSCLC. PD0325901/Saracatinib at 0.25:1 combination was screened against a panel of 28 NSCLC cell lines and 68% of cell lines were found to be sensitive (IC50 cell migration and matrigel invasion. The co-inhibition of MAPK and SRC induced strong G1/G0 cell cycle arrest in the NSCLC lines, inhibited anchorage independent growth and delayed tumor growth in H460 and H358 mouse xenografts. These data provide rationale for further investigating the combination of MAPK and SRC pathway inhibitors in advanced stage NSCLC.

  11. Isolation of a cdc28 mutation that abrogates the dependence of S phase on completion of M phase of the budding yeast cell cycle

    Indian Academy of Sciences (India)

    Santanu Kumar Ghosh; Pratima Sinha

    2000-01-01

    We have isolated a mutation in the budding yeast Saccharomyces cerevisisae CDC28 gene that allows cdc13 cells, carrying damaged DNA, to continue with the cell division cycle. While cdc13 mutant cells are arrested as large-budded cells at the nonpermissive temperature 37°C, the cdc13 cdc28 double mutant culture showed cells with one or more buds, most of which showed apical growth. The additional buds emerged without the intervening steps of nuclear division and cell separation. We suggest that the cdc28 mutation abrogates a checkpoint function and allows cells with damaged or incompletely replicated DNA an entry to another round of cell cycle and bypasses the mitotic phase of the cell cycle.

  12. Bill project aiming at abrogating exclusive search permits for unconventional hydrocarbon searches, and at prohibiting their exploration and exploitation of the national territory; Proposition de Loi visant a abroger les permis exclusifs de recherches d'hydrocarbures non conventionnels et a interdire leur exploration et leur exploitation sur le territoire national

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    After having briefly recalled the origin of shale gases, their extraction process and the evolution of their production in the USA, the authors outline the extremely negative environmental impacts of the fracking technique (hydraulic fracturing): water pollution, air pollution, soil pollution, existence of numerous drilling sites which would degrade landscapes, water and soil contamination risks. As some search permits have already been awarded, and while taking these negative consequences into account, the authors propose a bill project to prohibit these explorations, to abrogate the existing permits, and to ensure public information before bestowing such search permits and exploitation concessions

  13. La structure de la population après son lieu de naissance

    Directory of Open Access Journals (Sweden)

    Maria-Magdalena LUPCHIAN

    2008-10-01

    Full Text Available La capacité de polarisation de la ville de Suceava a agrandi d`une manière significative pendant la deuxième moitie de la XXème siècle, grâce au développement de la fonction industrielle de la ville entre 1960 et 1970. L`analyse de la structure de la population après le lieu de naissance a été possible grâceaux données fournies par les recensements de la population de 1930, 1966, 1977, 1992 et 2002(pour toute la ville et grâce aux données fournies par l`enquête réalisée en 2005 sur enéchantillon qui a dépassé 3000 personnes (pour l`analyse au niveau intra urbaine.Dans une première étape, l`aire de provenance de la population de la ville dépassaitles limites du département de Suceava. La ville a consolide son pouvoir d`attraction au niveaudu département et au niveau du Plateau de Suceava après les années `70. Pendant ce période(1950 – 1990, des déplacements très stables se sont développé entre les départements deBotoşani et de Neamţ et le département de Suceava.L`analyse de l`aire de provenance de la population née dans le département deSuceava relève le fait que la ville a représenté et représente encore un pole d`attraction pour lamoitie de plateau du département de Suceava. La ville chef lieu de département est enconcurrence avec les villes plus petites mais viables (Rădăuţi, Fălticeni, situées en proximité.L`analyse de la structure de la population après son lieu de naissance au niveau intraurbaine démontre l`opposition qui existe entre les vieux quartiers d`habitat individuel (ou lapopulation née en ville est majoritaire et les nouveaux quartiers, d`habitat collectif, édifiésdans les années d`industrialisation de la ville – Burdujeni, George Enescu – où le pourcentagede ceux nes dans le milieu rural est maximal.On remarque aussi la position intermédiaire du quartier Centre et des quartierspéricentraux, mais aussi du nouveau quartier Obcine, avec des pourcentage sur la

  14. Poesía y filosofía son de palabra

    Directory of Open Access Journals (Sweden)

    Santamaría Pargada, Antonio

    2006-04-01

    Full Text Available The imaginary and sinister concentration-camp chief Otto Friedrich Zur Linde was conceived by Jorge-Luis Borges as an example of misunderstanding philosophy and life, by seeing in them only the power of fight. This conception is compared with a dynamic understanding of philosophy. For Mr. Zur Linde Aristotle and Plato represent this confrontation, and each philosophical debate in history could be considered as a moment in it. But now, in the last fight, the will to power of man has gone beyond all the limits, even of morality. However some modern techniques of appropriation of ancient philosophy are completely opposed to this conception, namely Paul Ricoeur’s theory of fiction and Heidegger’s Sein und Schein,. Ultimately, the close relationship between poetry and philosophy since its origins speak against this thesis. A closer analysis of Nietzsche and Hölderlin will help to enlighten how wrong Zur Linde´s conception is..El siniestro jefe de un campo de concentración Otto Friedrich Zur Linde, concebido por Borges como ejemplo de una interpretación de la filosofía y la vida en la que la lucha es el único motor, es confrontado con una concepción de la filosofía dinámica. Zur Linde mantiene que Aristóteles y Platón son el enfrentamiento filosófico paradigmático. En el último momento del enfrentamiento la voluntad de poder de un nuevo superhombre ha rebasado todos los límites, incluso el de la conciencia. A esto se oponen las técnicas de apropiación filosófica del mundo griego por parte de la modernidad, a saber: el poder de la ficción, el Schein y el Sein así como el nacimiento de la filosofía, tan cercano a la poesía. Bajo este prisma cabe un análisis de Nietzsche y Hölderlin, que reniega de la interpretación de Zur Linde y clarifica que ante todo poetas y filósofos son seres de palabra.

  15. The role of God in the father/son relationship during identity formation – a Gestalt theoretical perspective

    Directory of Open Access Journals (Sweden)

    H.B. Grobler

    2010-07-01

    Full Text Available This article is based on research done within the Afrikaansspeaking community in the area of the Drakenstein Municipality, Western Cape province, South Africa. The focus falls specifically on one concept that was outlined during the research, namely the perceptions of fathers and adolescent sons on identity formation within their relationship as well as the role that God plays. Combined qualitative/quantitative research was conducted with emphasis on semi-structured interviews with fathers (n=4 and adolescent boys (n=4 and an auto-ethnography of the author as the dominant component. The lessdominant quantitative component consisted of questionnaires completed by fathers (n=42 and adolescent boys (n=180. Metatheoretical assumptions and theoretical assumptions as grounding for the male identity are discussed as part of the author’s paradigmatic perspective. Furthermore, empirical findings are discussed and recommendations are made. From the discussions with fathers and their sons it was clear that both fathers and sons have a need to stand in close relationship to each other and to God. It is within this relationship where their identities are formed. However, fathers seemed to be resistant of transferring their beliefs to their sons. Adolescent boys also indicated no need to one day transfer learned behaviour from their fathers to their sons.

  16. Analytical Modeling of SON MOSFET and Realization Inverter Circuit for High Speed and Ultra Dense Low Power Circuits

    Directory of Open Access Journals (Sweden)

    Kousik Naskar

    2012-06-01

    Full Text Available In the recent years, there has been considerable interest in the realization of high speed, small-size and low-power consuming devices and systems. As a consequence, the search for new principle of operation of the small-size, high speed and low-power device is becoming more and more important. In our earlier paper, it has been established that SON technology, not only improve the dc performance with reduce a short-channel effect and threshold voltage, it also improves the frequency response due to improvement in conductance and reduced parasitic effect. Further, it is already in our knowledge that SCEs are suppressed in dual material gate MOSFETs because of the perceivable step in the surface-potential profile, which screens the drain potential. The concept of dual material gate has been applied to SON MOSFETs structure and the features exhibited by resulting new SON structure has been examined for the first time by developing an analytical model and the result agree well with the MEDICI simulation values. In order to substantiate the merits of the proposed SON MOSFETs, a MOS Inverter is realized using the SON MOSFETs and its performance is investigated as an aid to the high-speed, ultra-dense and low-power circuit related work.

  17. "There is such a thing as too many daughters, but not too many sons": A qualitative study of son preference and fetal sex selection among Indian immigrants in the United States.

    Science.gov (United States)

    Puri, Sunita; Adams, Vincanne; Ivey, Susan; Nachtigall, Robert D

    2011-04-01

    In response to concerns from feminists, demographers, bioethicists, journalists, and health care professionals, the Indian government passed legislation in 1994 and 2003 prohibiting the use of sex selection technology and sex-selective abortion. In contrast, South Asian families immigrating to the United States find themselves in an environment where reproductive choice is protected by law and technologies enabling sex selection are readily available. Yet there has been little research exploring immigrant Indian women's narratives about the pressure they face to have sons, the process of deciding to utilize sex selection technologies, and the physical and emotional health implications of both son preference and sex selection. We undertook semi-structured, in-depth interviews with 65 immigrant Indian women in the United States who had pursued fetal sex selection on the East and West coasts of the United States between September 2004 and December 2009. Women spoke of son preference and sex selection as separate though intimately related phenomena, and the major themes that arose during interviews included the sociocultural roots of son preference; women's early socialization around the importance of sons; the different forms of pressure to have sons that women experienced from female in-laws and husbands; the spectrum of verbal and physical abuse that women faced when they did not have male children and/or when they found out they were carrying a female fetus; and the ambivalence with which women regarded their own experience of reproductive "choice." We found that 40% of the women interviewed had terminated prior pregnancies with female fetuses and that 89% of women carrying female fetuses in their current pregnancy pursued an abortion. These narratives highlight the interaction between medical technology and the perpetuation of this specific form of violence against women in an immigrant context where women are both the assumed beneficiaries of reproductive choice

  18. Evolution of the local environment of lanthanum during simplified SON68 glass leaching

    Energy Technology Data Exchange (ETDEWEB)

    Jollivet, P.; Delaye, J.M. [CEA, Lab Comportement Long Terme, F-30207 Bagnols Sur Ceze (France); Den Auwer, C. [CEA, Lab Concept Architectures Mol, F-30207 Bagnols Sur Ceze (France); Simoni, E. [Inst Phys Nucl, F-91406 Orsay (France)

    2007-03-15

    The evolution of the short- and medium-range local environment of lanthanum was determined by L-III-edge X-ray absorption spectroscopy (XAS) during leaching of simplified SON68-type glasses. In glass without phosphorus, lanthanum is found in a silicate environment, and its first coordination sphere comprises eight oxygen atoms at a mean distance of 2.51 angstrom. When this glass was leached at a high renewal rate, the lanthanum local environment was significantly modified: it was present at hydroxy-carbonate and silicate sites with a mean La-O distance of 2.56 angstrom, and the second neighbors consisted of La atoms instead of Si for the glass. Conversely, in the gel formed at low renewal rates, lanthanum was found in a silicate environment similar to that of the glass. In phosphorus-doped glass, lanthanum is found in a phosphate environment, although the Si/P atomic ratio is 20:1. Lanthanum is surrounded by seven oxygen atoms at a mean distance of 2.37 angstrom. When phosphorus-doped glass is leached, regardless of the leaching solution flow rate, the short- and medium-range lanthanum local environment remains almost constant; the most significant change is a 0.05 angstrom increase in the La-O distance. (authors)

  19. Evolution of the local environment of cerium and neodymium during simplified SON68 glass alteration

    Energy Technology Data Exchange (ETDEWEB)

    Jollivet, Patrick [Commissariat a l' Energie Atomique (CEA), Rhone Valley Research Center, BP 17171, 30207 Bagnols-sur-Ceze (France)]. E-mail: patrick.jollivet@cea.fr; Lopez, Christophe [Commissariat a l' Energie Atomique (CEA), Rhone Valley Research Center, BP 17171, 30207 Bagnols-sur-Ceze (France); Auwer, Christophe Den [Commissariat a l' Energie Atomique (CEA), Rhone Valley Research Center, BP 17171, 30207 Bagnols-sur-Ceze (France); Simoni, Eric [Institut de Physique Nucleaire, Batiment 100, 91406 Orsay cedex (France)

    2005-11-15

    The evolution of the sites occupied by cerium and neodymium (coordination numbers and Ce, Nd-O distances) during alteration of simplified SON68 glass specimens was determined by L{sub III}-edge XAS. Cerium and neodymium are situated in a silicate environment in the glass, surrounded by eight oxygen atoms at an average distance of 2.44 and 2.48 A, respectively. These two rare earth elements exhibit different leaching behavior, however. The main environment of cerium becomes a silicate (d {sub Ce-O} = 2.19 A) with a second oxide or more probably oxyhydroxide site (d {sub Ce-O} = 2.32 A). The cerium coordination number increases by 1 to 3 compared with the glass, depending on the leaching conditions. Neodymium is found mainly in a hydroxycarbonate environment (d {sub Nd-O} = 2.46 A); the second site is a silicate (d {sub Nd-O} = 2.54 A). The neodymium coordination number increases by 1 compared with the glass. When glass containing neodymium is doped with phosphorus, Nd is situated in a phosphate environment; this change is also reflected in the coordination number and Nd-O distance (seven oxygen atoms at 2.42 A). During glass leaching, neodymium is present at two different sites, phosphate (d {sub Nd-O} = 2.52 A) and hydroxycarbonate (d {sub Nd-O} = 2.40 A)

  20. Evolution of the local environment of lanthanum during simplified SON68 glass leaching

    International Nuclear Information System (INIS)

    The evolution of the short- and medium-range local environment of lanthanum was determined by L-III-edge X-ray absorption spectroscopy (XAS) during leaching of simplified SON68-type glasses. In glass without phosphorus, lanthanum is found in a silicate environment, and its first coordination sphere comprises eight oxygen atoms at a mean distance of 2.51 angstrom. When this glass was leached at a high renewal rate, the lanthanum local environment was significantly modified: it was present at hydroxy-carbonate and silicate sites with a mean La-O distance of 2.56 angstrom, and the second neighbors consisted of La atoms instead of Si for the glass. Conversely, in the gel formed at low renewal rates, lanthanum was found in a silicate environment similar to that of the glass. In phosphorus-doped glass, lanthanum is found in a phosphate environment, although the Si/P atomic ratio is 20:1. Lanthanum is surrounded by seven oxygen atoms at a mean distance of 2.37 angstrom. When phosphorus-doped glass is leached, regardless of the leaching solution flow rate, the short- and medium-range lanthanum local environment remains almost constant; the most significant change is a 0.05 angstrom increase in the La-O distance. (authors)

  1. A Novel Dynamic Adjusting Algorithm for Load Balancing and Handover Co-Optimization in LTE SON

    Institute of Scientific and Technical Information of China (English)

    Wen-Yu Li; Xiang Zhang; Shu-Cong Jia; Xin-Yu Gu; Lin Zhang; Xiao-Yu Duan; Jia-Ru Lin

    2013-01-01

    With the development of mobile internet and multi-media service,advanced techniques need to be applied in wireless network to improve user experience.Long term evolution (LTE) systems,which can offer up to 100Mbps downlink date rates,have been deployed in USA and Korea.However,because plenty of complex physical layer algorithms are utilized,network planning and optimization become heavy burdens for LTE network operators.Self-organizing network (SON) is a promising method to overcome this problem by automatically selecting and adjusting key parameters in LTE systems.In this paper,we present a dynamic adjusting algorithm to improve both handover and load balancing performance by introducing a weighted co-satisfaction factor (CSF).Analysis and system level simulation are conducted to exhibit the performance improvement of the proposed scheme.Results show that the proposed method outperforms the conventional solutions in terms of the network handover success ratio and load balancing gains significantly.

  2. Los saberes indígenas son patrimonio de la humanidad

    Directory of Open Access Journals (Sweden)

    José Narciso Jamioy Muchavisoy

    1997-10-01

    Full Text Available Bajo la premisa de que narrar en pocas palabras los saberes milenarios de los distintos pueblos es irrespetuoso e irresponsable, ya que se puede caer en interpretaciones superficiales y erradas sobre aquellos conocimientos que para ellos son sagrados, el autor se limita a presentar un panorama muy general de cómo dichos conocimientos generan vida e identidad en las nuevas generaciones mediante procesos de tradición oral por los padres, abuelos, tíos y, en especial, por los ancianos sabedores de los pueblos y comunidades indígenas. La explicación es fruto de sus experiencias como hijo de una familia que conservó la tradición Kamëntsá, como acompañante en algunas actividades de reflexión realizadas con voceros del ordennacional y con las comunidades de los pueblos Arhuaco, Paéz, Guambiano,Pastos, Ticuna, Cofán e Inga. Así mismo, de sus vivencias como estudian- te, docente de colegio, catedrático universitario e investigador.

  3. Violencia cometida por los adolescentes en la familia o cuando son los hijos los que maltratan

    Directory of Open Access Journals (Sweden)

    Helena Morales Ortega

    2011-12-01

    Full Text Available Este estudio de tipo cualitativo, de corte deductivo, se propuso realizar un acercamiento al fenómeno de la violencia ejercida por los jóvenes menores de 18 años en el ámbito familiar, para establecer su ocurrencia en la ciudad de Barranquilla, Colombia, describir las características de los jóvenes implicados, la dinámica familiar y algunos aspectos del entorno social que podrían estar facilitando la ocurrencia de la misma. El estudio fue realizado en el Centro de Reeducación del Adolescente Infractor "Oasis", de esta ciudad; se examinaron expedientes de jóvenes judicializados por los delitos de violencia intrafamiliar, hurto, lesiones personales y daño en bien ajeno, donde la víctima había sido un familiar; igualmente, se realizaron entrevistas semiestructuradas con profundidad a madres de jóvenes que al momento de la investigación se hallaban internos en el centro por violencia en la familia. Los resultados indican que son pocos los estudios criminológicos realizados sobre el tema; se trata de jóvenes con edades promedio de 14 a 17 años, provenientes de familias desintegradas, con carencias tanto materiales como afectivas, con dinámicas y estilos de crianza inadecuados; es frecuente en estos jóvenes el consumo de sustancias alucinógenas o alcohol.

  4. Meta-analysis suggests choosy females get sexy sons more than "good genes".

    Science.gov (United States)

    Prokop, Zofia M; Michalczyk, Łukasz; Drobniak, Szymon M; Herdegen, Magdalena; Radwan, Jacek

    2012-09-01

    Female preferences for specific male phenotypes have been documented across a wide range of animal taxa, including numerous species where males contribute only gametes to offspring production. Yet, selective pressures maintaining such preferences are among the major unknowns of evolutionary biology. Theoretical studies suggest that preferences can evolve if they confer genetic benefits in terms of increased attractiveness of sons ("Fisherian" models) or overall fitness of offspring ("good genes" models). These two types of models predict, respectively, that male attractiveness is heritable and genetically correlated with fitness. In this meta-analysis, we draw general conclusions from over two decades worth of empirical studies testing these predictions (90 studies on 55 species in total). We found evidence for heritability of male attractiveness. However, attractiveness showed no association with traits directly associated with fitness (life-history traits). Interestingly, it did show a positive correlation with physiological traits, which include immunocompetence and condition. In conclusion, our results support "Fisherian" models of preference evolution, while providing equivocal evidence for "good genes." We pinpoint research directions that should stimulate progress in our understanding of the evolution of female choice. PMID:22946794

  5. Two sons and a daughter: sex composition and women's reproductive behaviour in Madhya Pradesh, India.

    Science.gov (United States)

    Edmeades, Jeffrey; Pande, Rohini; Macquarrie, Kerry; Falle, Tina; Malhotra, Anju

    2012-11-01

    This article examines how the sex composition of women's current children at the start of a pregnancy interval influences both fertility desires and the full range of reproductive actions women may take to realize them, including temporary contraception, abortion and sterilization, in Madhya Pradesh, India, where popular notions of ideal family size and sex composition are dominated by son preference. The analysis is conducted using a dataset of 9127 individual pregnancy intervals from a 2002 statewide representative survey of 2444 women aged 15-39 with at least one child. The results indicate that women's preferences go beyond a singular preference for male children, with the preferred composition of children being two boys and one girl. Women with this composition are 90% less likely to report having wanted another pregnancy (OR 0.097, p < 0.01) relative to those with two girls. These preferences have significant implications for reproductive actions. While sex composition has no statistically significant effect on the use of temporary contraception, those with the preferred sex composition are twice as likely to attempt abortion (OR 2.436, p < 0.01) and twelve times more likely to be sterilized (OR 12.297, p < 0.01) relative to those with two girls only.

  6. Une pensée en action du son au théâtre

    Directory of Open Access Journals (Sweden)

    Jean-Paul Quéinnec

    2011-09-01

    Full Text Available En cherchant à ne plus soumettre le son à l’action dramatique, le statut de la dramaturgie théâtrale (textuelle et scénique se met à dériver. Un glissement de la pensée comme de la pratique qui appelle une écoute à d’autres références théoriques et méthodologiques. Cet article s’appuie sur une recherche création en dramaturgie sonore qui explore la notion d’intermédialité et la création performative au théâtre. Un vécu expérientiel de la matérialité sonore (texte, objet, espace qui développe un concept que nous nommons « dramaturgie informe » car le théâtre contemporain devenu matière vive et complexe s’avère difficile à isoler pour être défini.

  7. Mothers, fathers, sons and daughters: parental sensitivity in families with two children.

    Science.gov (United States)

    Hallers-Haalboom, Elizabeth T; Mesman, Judi; Groeneveld, Marleen G; Endendijk, Joyce J; van Berkel, Sheila R; van der Pol, Lotte D; Bakermans-Kranenburg, Marian J

    2014-04-01

    Most studies on early childhood parenting include only mothers. Fathers are rarely observed in interaction with their young children, although they play an important role in the socialization of their children. In this study, we observed parenting of mothers and fathers toward their sons and daughters in families with two children, using a within-family approach in a sample with systematically varying family constellations. Participants included 389 families with two children (1 and 3 years of age). Parenting practices were coded during free play using the Emotional Availability Scales (Biringen, 2008). Findings revealed that mothers showed higher levels of sensitivity and lower levels of intrusiveness toward their children than fathers. Furthermore, mothers and fathers were more sensitive and less intrusive toward their oldest child than toward their youngest child. Fathers' higher intrusiveness toward the youngest child was only found in the case of a youngest boy. Child gender was not related to parenting in any of the other analyses. Our results suggest that parent gender is more salient than child gender in the prediction of parenting practices in early childhood. PMID:24635666

  8. Chemical Precipitation of Ammonia and Phosphatefrom Nam Son Landfill Leachate, Hanoi

    Directory of Open Access Journals (Sweden)

    Nguyen Manh Khai

    2012-01-01

    Full Text Available Leachate from municipal landfills of the city is often contaminated heavily, especially for parameters such as organic components, heavy metals, microorganisms. However, leachate also contains amounts of valuable nutrients (e.g. N, P, K which can be used for agriculture as fertilizers. Precipitated of N and P in the form of struvite (MgNH4PO4.6H2O might be applied as a technique for removal a huge amount of N as well as P in wastewater. This study investigated the recovery ability of N, P in leachate from Nam Son municipal landfill of Hanoi city. Different pH values, anaerobic time and stoichiometric Mg2+: NH4+: PO43- was tested to determine the optimal conditions for precipitating struvite. The effect of pH on the forming of struvite was between pH 9 to 11. The results showed that nutrients in landfill leachate could be recovered with the optimum pH around 9.5 and the optimum Mg2+: NH4+: PO43- molar ratio as 1.15: 1: 1. With the anaerobic interval of 21 days, COD value in landfill leachate was decreased to 60%, the retrieval reached 80.6% for nitrogen and 82.7% for phosphorus. According to estimates, with the application of struvite precipitation technique, the average annual retrieval amount of NH4+ and PO43- can reach 263 tons and 25 tons, respectively.

  9. Complicity to Hegemonic Masculinity in D.H. Lawrence’s Sons and Lovers

    Directory of Open Access Journals (Sweden)

    Angelina Subrayan

    2016-04-01

    Full Text Available Men have long been associated with dominance, strength and confidence and the issue regarding being compliant to the acceptable masculine ideal has always been part of a culture’s social identity. This study focuses on the critical discussion on masculinity studies in the classic fiction of D.H Lawrence.  Drawing on narrative data from his novel Sons and Lovers (1913, the study examines how hegemonic masculinity is conformed by the male protagonist, Walter Morel, in his gendered relationship. More specifically, the analysis focuses on how the male character aligns himself with the hegemonically authoritarian philosophy of ‘tough’ masculinity. The effects of social practices and socio-historical context in which Lawrence wrote these novels are also examined. The study utilises Connell’s theory of hegemonic masculinity to explicate Lawrence’s depiction of dominant masculinity through his character. The findings reveal that Lawrence aligns his male protagonist to the dominant role by sanctioning aggressiveness, autonomy and violence.Keywords: Hegemonic Masculinity, Dominant Masculinity, Patriarchy, Gender, Power

  10. Otočno obratovanje sončne elektrarne enodružinske hiše

    OpenAIRE

    Koncilja, Rok

    2016-01-01

    Tema moje diplomske naloge je otočno delovanje sončne elektrarne enodružinske hiše. V uvodu izvemo nekaj o samooskrbi z električno energijo ter o samem delovanju manjše sončne elektrarne. V glavnem delu naloge je najprej, s pomočjo tlorisnih načrtov enodružinske hiše, opisana dnevna poraba električne energije. V nadaljevanju sem pri izračunu sončnega obsevanja za naš solarni sistem upošteval konkretne parametre, pomagal pa sem si s podatki meteoroloških postaj. Rezultat so dnevne vrednost...

  11. Design and Analysis of a High Speed, Power Efficient 8 Bit ALU Based on SOI / SON MOSFET Technology

    Directory of Open Access Journals (Sweden)

    Subhramita Basak

    2014-01-01

    Full Text Available This paper shows an overall performance comparative analysis in terms of Average Power Consumption, Average Delay and Power-Delay Product for an 8 bit Arithmetic Logic Unit (ALU using bulk MOS, Silicon-on-Insulator (SOI and Silicon-on-Nothing (SON technology. The entire design is done in 32nm technology for all the three cases (Bulk, SOI & SON and then compared. The comparisons have been carried out with the help of the simulation runs on Synopsys HSpice tool, and that clearly indicates, for lower Supply Voltages (Vdd, SOI / SON technology provides a significant reduction in Average Power Consumption, Average Delay and Power-Delay Product compared to that of Bulk MOS technology.

  12. En realidades sociales de múltiples pobrezas cómo son el juego y las relaciones de poder

    OpenAIRE

    Madueño, Juan Agustín

    2013-01-01

    En realidades sociales de "múltiples pobrezas", como son el juego y las relaciones de poder con sujetos adolescentes y jóvenes que concurren a las prácticas en recreación durante el 2000 al 2005. Con un sentido de criterio etnográfico, y bajo una mirada de un enfoque cualitativo, como son los cruces en lo atañe a las actividades recreativas y los juegos en esas poblaciones, y cual es la microfísica de poder que se establecen en las relaciones con las coordinaciones de los estudiantes en recre...

  13. Alexander Falconer Sr Seamen's missionary in New Zealand, son Alexander Falconer medical superintendent for mentally ill, grandson Murray Falconer neurosurgeon.

    Science.gov (United States)

    Hawgood, Barbara J

    2016-08-01

    Alexander Falconer Sr (1843-1915) came from Scotland to New Zealand. A practical Christian, he set up places of relaxation for miners, sailors and soldiers; he became the Seamen's Missionary. Son, Dr Alexander Falconer (1874-1955) trained at Otago University Medical School. As medical superintendent for the mentally ill, he urged the early introduction of psychotherapy. His son, Murray Falconer (1910-1977) was the first Nuffield Dominions Clinical Fellow, training in neurosurgery in Oxford. He was the first director of the Guy's-Maudsley Neurosurgical Unit in London and was internationally known for the surgical management of temporal lobe epilepsy in adults and children. PMID:26025843

  14. Inhibition of lanthanide nanocrystal-induced inflammasome activation in macrophages by a surface coating peptide through abrogation of ROS production and TRPM2-mediated Ca(2+) influx.

    Science.gov (United States)

    Yao, Han; Zhang, Yunjiao; Liu, Liu; Xu, Youcui; Liu, Xi; Lin, Jun; Zhou, Wei; Wei, Pengfei; Jin, Peipei; Wen, Long-Ping

    2016-11-01

    Lanthanide-based nanoparticles (LNs) hold great promise in medicine. A variety of nanocrystals, including LNs, elicits potent inflammatory response through activation of NLRP3 inflammasome. We have previously identified an LNs-specific surface coating peptide RE-1, with the sequence of 'ACTARSPWICG', which reduced nanocrystal-cell interaction and abrogated LNs-induced autophagy and toxicity in both HeLa cells and liver hepatocytes. Here we show that RE-1 coating effectively inhibited LNs-induced inflammasome activation, mostly mediated by NLRP3, in mouse bone marrow derived macrophage (BMDM) cells, human THP-1 cells and mouse peritoneal macrophages and also reduced LNs-elicited inflammatory response in vivo. RE-1 coating had no effect on cellular internalization of LNs in BMDM cells, in contrast to the situation in HeLa cells where cell uptake of LNs was significantly inhibited by RE-1. To elucidate the molecular mechanism underlying the inflammasome-inhibiting effect of RE-1, we assessed several parameters known to influence nanocrystal-induced NLRP3 inflammasome activation. RE-1 coating did not reduce potassium efflux, which occurred after LNs treatment in BMDM cells and was necessary but insufficient for LNs-induced inflammasome activation. RE-1 did decrease lysosomal damage induced by LNs, but the inhibitor of cathepsin B did not affect LNs-elicited caspase 1 activation and IL-1β release, suggesting that lysosomal damage was not critically important for LNs-induced inflammasome activation. On the other hand, LNs-induced elevation of intracellular reactive oxygen species (ROS), critically important for inflammasome activation, was largely abolished by RE-1 coating, with the reduction on NADPH oxidase-generated ROS playing a more prominent role for RE-1's inflammasome-inhibiting effect than the reduction on mitochondria-generated ROS. ROS generation further triggered Ca(2+) influx, an event that was mediated by Transient Receptor Potential M2 (TRPM2) and was

  15. Knockdown of platinum-induced growth differentiation factor 15 abrogates p27-mediated tumor growth delay in the chemoresistant ovarian cancer model A2780cis

    International Nuclear Information System (INIS)

    Molecular mechanisms underlying the development of resistance to platinum-based treatment in patients with ovarian cancer remain poorly understood. This is mainly due to the lack of appropriate in vivo models allowing the identification of resistance-related factors. In this study, we used human whole-genome microarrays and linear model analysis to identify potential resistance-related genes by comparing the expression profiles of the parental human ovarian cancer model A2780 and its platinum-resistant variant A2780cis before and after carboplatin treatment in vivo. Growth differentiation factor 15 (GDF15) was identified as one of five potential resistance-related genes in the A2780cis tumor model. Although A2780-bearing mice showed a strong carboplatin-induced increase of GDF15 plasma levels, the basal higher GDF15 plasma levels of A2780cis-bearing mice showed no further increase after short-term or long-term carboplatin treatment. This correlated with a decreased DNA damage response, enhanced AKT survival signaling and abrogated cell cycle arrest in the carboplatin-treated A2780cis tumors. Furthermore, knockdown of GDF15 in A2780cis cells did not alter cell proliferation but enhanced cell migration and colony size in vitro. Interestingly, in vivo knockdown of GDF15 in the A2780cis model led to a basal-enhanced tumor growth, but increased sensitivity to carboplatin treatment as compared to the control-transduced A2780cis tumors. This was associated with larger necrotic areas, a lobular tumor structure and increased p53 and p16 expression of the carboplatin-treated shGDF15-A2780cis tumors. Furthermore, shRNA-mediated GDF15 knockdown abrogated p27 expression as compared to control-transduced A2780cis tumors. In conclusion, these data show that GDF15 may contribute to carboplatin resistance by suppressing tumor growth through p27. These data show that GDF15 might serve as a novel treatment target in women with platinum-resistant ovarian cancer

  16. EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage

    Directory of Open Access Journals (Sweden)

    Kuroda S

    2014-08-01

    Full Text Available Shinji Kuroda,1 Justina Tam,2 Jack A Roth,1 Konstantin Sokolov,2 Rajagopal Ramesh3–5 1Department of Thoracic and Cardiovascular Surgery, 2Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 3Department of Pathology, 4Graduate Program in Biomedical Sciences, 5Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Background: We have previously demonstrated the epidermal growth factor receptor (EGFR-targeted hybrid plasmonic magnetic nanoparticles (225-NP produce a therapeutic effect in human lung cancer cell lines in vitro. In the present study, we investigated the molecular mechanism of 225-NP-mediated antitumor activity both in vitro and in vivo using the EGFR-mutant HCC827 cell line. Methods: The growth inhibitory effect of 225-NP on lung tumor cells was determined by cell viability and cell-cycle analysis. Protein expression related to autophagy, apoptosis, and DNA-damage were determined by Western blotting and immunofluorescence. An in vivo efficacy study was conducted using a human lung tumor xenograft mouse model. Results: The 225-NP treatment markedly reduced tumor cell viability at 72 hours compared with the cell viability in control treatment groups. Cell-cycle analysis showed the percentage of cells in the G2/M phase was reduced when treated with 225-NP, with a concomitant increase in the number of cells in Sub-G1 phase, indicative of cell death. Western blotting showed LC3B and PARP cleavage, indicating 225-NP-treatment activated both autophagy- and apoptosis-mediated cell death. The 225-NP strongly induced γH2AX and phosphorylated histone H3, markers indicative of DNA damage and mitosis, respectively. Additionally, significant γH2AX foci formation was observed in 225-NP-treated cells compared with control treatment groups, suggesting 225-NP induced cell death by triggering DNA damage. The 225-NP-mediated DNA damage involved abrogation of the

  17. Son preference among the historical Sandžak Muslim population

    Directory of Open Access Journals (Sweden)

    Čvorović Jelena

    2012-01-01

    Full Text Available This paper attempts to explain parental son preferences among historical Muslim population in the Sandžak region, southwestern Serbia. The paper draws upon data collected in the course of anthropological fieldwork studies in the region. The fieldwork was performed among Muslim and Christian families in Serbian rural area of Sandžak, measuring maternal fitness in relation to several variables. The data set comes from 120 women born between 1880-1924, representing so a historical demographic data based on individual and lineage records. These data were complemented with official records from Archive of Novi Pazar, whenever possible. In this Serbian rural area, land is still considered as an abundant resource, useful in establishing a family, livestock or agriculture. In the past, in spite of yearly fluctuations in production, lands and labor constituted a stable source of wealth from generation to generation. In this study, the data include the socio-economic status of each woman, assigned according to her husband’s family economic status: land-ownership vs. landless. This represents differences in resource availability in terms of nutrition, wealth and workload among these women. As the results show, the Muslim families, on average, left more surviving descendants through sons, in contrast with their Christian counterparts. The basic research question, then, is why? Furthermore, what were the impacts of particular behaviors on reproductive and lineage success, under particular social and ecological conditions? In this sample, regarding the Muslim families, the family structure was/is traditional and stratified, characterized by a large disparity in the status of males and females. Patrilineal inheritance, the concentration of wealth and power in males and the social restriction of women all characterize even today this patriarchal family arrangement. This supports the Trivers-Willard hypothesis, especially in terms of sex-biased parental

  18. PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation.

    Science.gov (United States)

    Mabeta, Peace

    2016-09-01

    PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors, namely, endothelioma cells. The treatment of endothelioma cells with PF573,228 reduced their growth with an IC50 of approximately 4.6 μmol L-1 and inhibited cell migration with an IC50 of about 0.01 μmol L-1. Microscopic studies revealed morphological attributes of apoptosis. These observations were confirmed by ELISA, which showed increased caspase-3 activity. PF573,228 also inhibited angiogenesis in a dose-dependent manner, with an IC50 of approximately 3.7 μmol L-1, and abrogated the phosphorylation of cell survival proteins, proline-rich Akt substrate (PRAS40) and S6 ribosomal protein (S6RP). Array data further revealed that PF573,228 induced caspase-3 activation, thus promoting apoptosis. Since all the processes inhibited by PF573,228 provide important support to tumor survival and progression, the drug may have a potential role in the treatment of vascular tumors. PMID:27383888

  19. Pathways to Prevention: Improving Nonresident African American Fathers' Parenting Skills and Behaviors to Reduce Sons' Aggression

    Science.gov (United States)

    Caldwell, Cleopatra Howard; Antonakos, Cathy L.; Assari, Shervin; Kruger, Daniel; De Loney, E. Hill; Njai, Rashid

    2014-01-01

    This study describes a test of the Fathers and Sons Program for increasing intentions to avoid violence and reducing aggressive behaviors in 8-to 12-year-old African American boys by enhancing the parenting skills satisfaction and parenting behaviors of their nonresident fathers. The study included 158 intervention and 129 comparison group…

  20. Self-Regulation in Early Adolescence: Relations with Mother-Son Relationship Quality and Maternal Regulatory Support and Antagonism

    Science.gov (United States)

    Moilanen, Kristin L.; Shaw, Daniel S.; Fitzpatrick, Amber

    2010-01-01

    The purpose of the current investigation was to examine relations among maternal regulatory support, maternal antagonism, and mother-son relationship quality in relation to boys' self-regulation during early adolescence. As part of a larger longitudinal study on 263 low-income, ethnically diverse boys, multiple informants and methods were used to…

  1. The Quest of Father and Son: Illuminating Character Identity, Motivation, and Conflict in Cormac McCarthy's "The Road"

    Science.gov (United States)

    Gilbert, Chris

    2012-01-01

    "The Road" has been an important part of the author's English IV Honors course for several years now. Undeniably bleak, it details a father and son's journey through a seared, post-apocalyptic wasteland. As they travel through the burnt remains of America, they are threatened by starvation, dehydration, and scattered, hostile humans. Although his…

  2. Return Migration, Investment in Children, and Intergenerational Mobility: Comparing Sons of Foreign- and Native-Born Fathers

    Science.gov (United States)

    Dustmann, Christian

    2008-01-01

    This paper studies parental investment in education and intergenerational earnings mobility for father-son pairs with native- and foreign-born fathers. We illustrate within a simple model that for immigrants, investment in their children is related to their return migration probability. In our empirical analysis, we include a measure for return…

  3. Examination of the Film "My Father and My Son" According to the Basic Concepts of Multigenerational Family Therapy

    Science.gov (United States)

    Acar, Tulin; Voltan-Acar, Nilufer

    2013-01-01

    The aim of this study was to evaluate the basic concepts of multigenerational Family Therapy and to evaluate the scenes of the film ''My Father and My Son'' according to these concepts. For these purposes firstly basic concepts of Multigenerational Family Therapy such as differentiation of self, triangles/triangulation, nuclear…

  4. 77 FR 72906 - Chessie Logistics Co., LLC-Acquisition and Operation Exemption-J. Emil Anderson & Son, Inc.

    Science.gov (United States)

    2012-12-06

    ... Surface Transportation Board Chessie Logistics Co., LLC--Acquisition and Operation Exemption-- J. Emil Anderson & Son, Inc. Chessie Logistics Co., LLC (Chessie), a noncarrier, has filed a verified notice of... copy of each pleading must be served on Ariel A. Erbacher, Legal Counsel, Chessie Logistics Co.,...

  5. Giving Birth to Life--Again!: Bereaved Parents' Experiences with Children Born Following the Death of an Adult Son

    Science.gov (United States)

    Hamama-Raz, Yaira; Rosenfeld, Sarah; Buchbinder, Eli

    2010-01-01

    This article is based on a qualitative study examining the experiences of parents that lost a son during military service in Israel and consequently choose to give birth to another child. Seven couples and 3 mothers were interviewed for the study, and their interviews were analyzed using a phenomenological-hermeneutic approach. Three main themes…

  6. An evolutionary psychological investigation of parental distress and reproductive coercion during the "coming out" of gay sons.

    Science.gov (United States)

    Wisniewski, Timothy J; Robinson, Thomas N; Deluty, Robert H

    2010-01-01

    The lack of success of the "coming out" studies over the last three decades to explain and predict parental responses has motivated an evolutionary psychological reconceptualization. According to this reconceptualization, it was predicted that (a) biological mothers would experience more distress and apply more pressure on gay sons to change than would biological fathers and; (b) obligate investment for fathers on dependent sons would cause fathers to experience more distress and apply more pressure on gay sons to change than it would fathers without this obligate investment. In contrast, a cultural-norm hypothesis predicted that fathers would experience more distress and apply more pressure on gay sons to change than mothers. The majority of predictions were tested using 787 participants from two-biological parent families, who were drawn from a total sample of 891 participants from various family backgrounds. As predicted by the evolutionary hypothesis, biological mothers were reported to have been more distressed and coercive than biological fathers, in spite of a strong, societal expectation to the contrary. Furthermore, the results supported the obligate investment argument for paternal reactions. The model not only correctly explained and predicted parental behavior during coming out, but also was shown to unify within its theoretical framework discrepant results from the literature previously considered inconsistent. PMID:20069499

  7. BiSON data preparation: A correction for differential extinction and the weighted averaging of contemporaneous data

    CERN Document Server

    Davies, G R; Elsworth, Y; Hale, S J

    2014-01-01

    The Birmingham Solar Oscillations Network (BiSON) has provided high-quality high-cadence observations from as far back in time as 1978. These data must be calibrated from the raw observations into radial velocity and the quality of the calibration has a large impact on the signal-to-noise ratio of the final time series. The aim of this work is to maximise the potential science that can be performed with the BiSON data set by optimising the calibration procedure. To achieve better levels of signal-to-noise ratio we perform two key steps in the calibration process: we attempt a correction for terrestrial atmospheric differential extinction; and the resulting improvement in the calibration allows us to perform weighted averaging of contemporaneous data from different BiSON stations. The improvements listed produce significant improvement in the signal-to-noise ratio of the BiSON frequency-power spectrum across all frequency ranges. The reduction of noise in the power spectrum will allow future work to provide gr...

  8. Beating the Odds: How Single Black Mothers Influence the Educational Success of Their Sons Enrolled in Failing Schools

    Science.gov (United States)

    Robinson, Quintin L.; Werblow, Jacob

    2012-01-01

    The academy has given little attention to academically successful Black males and the factors that may lead to their successes. This multiple case study design, however, examined the ways in which single-Black mothers influence the educational success of their sons by focusing on the mothers of academically successful 11th grade Black males. Data…

  9. "My Son Is Reliable": Young Drivers' Parents' Optimism and Views on the Norms of Parental Involvement in Youth Driving

    Science.gov (United States)

    Guttman, Nurit

    2013-01-01

    The high crash rates among teenage drivers are of great concern across nations. Parents' involvement is known to help increase their young drivers' driving safety. In particular, parents can place restrictions on their son's/daughter's driving (e.g., restrict night time driving), which can enable the young driver to gain driving experience in…

  10. Compared study of the local structure of alteration products of SON 68 glass and natural gels; Etude comparee de la structure locale des produits d'alteration du verre SON 68 et de gels naturels

    Energy Technology Data Exchange (ETDEWEB)

    Pellegrin, E

    2000-07-01

    This study is a contribution in the understanding of the long time behavior of alteration products of the glass SON 68, used to simulate the nuclear glass R7T7. The local structure around Zirconium and iron has been probed using X-ray absorption spectroscopy in altered surface layer of glass SON 68. Alteration products of this glass have been prepared for short (3 hours to 7 days) and long (17 months) time, using various indexes of saturation for the leaching solution with respect to the Si content of the glass (from 0 to 90 %). The evolution of the local structure around Fe has also been studied in recent and old natural ferric gels. Zr, Fe- L{sub 2,3} XANES and Zr, Fe-K EXAFS spectroscopies have shown that, in the pristine glass, these elements are connected to the polymeric network. Zr is found in an environment close to that of a zircon-silicate containing Na and Ca. Trivalent Fe is a network former. The leached layer of glass SON 68 is constituted of poorly ordered Zr-and Fe-(oxi-hydr)oxides that may have been formed by a mechanism of dissolution/precipitation; a relict phase with the same Zr local structure as that observed in the pristine glass, probably obtained thanks to in-situ solid condensation. The structural characteristics of the leached layer are observed from the first steps of alteration for Zr and Fe. Conversely to Fe, the structural status of Zr depends on the leaching kinetic as well as the contents of Ca and Si in the solid. Fe-K EXAFS results in recent natural ferri-hydrides present a clear structural similarity with that determined in glass SON 68 leached products. The study of old paleosols (between 1,800 and 200,000 years) has demonstrated the long time stability of ferric gels, although an increase of medium range order around Fe is seen. (author)

  11. Applicability of the SON-R 6-40 Non-verbal Intelligence Test in China%SON-R6-40非言语智力测验在中国的适用性

    Institute of Scientific and Technical Information of China (English)

    徐建平; 郭枝; 王茜; Peter Tellegen

    2014-01-01

    SON-R 6-40非言语智力测验是以非文字形式测量个体推理与空间能力的智力评估工具.研究旨在考查SON-R6-40在中国的适用性.根据全国人口分布,在中国六大行政区6至40岁年龄人群中施测了1721人,通过与荷兰/德国混合样本比较,分析该测验的跨文化等值水平.结果表明:(1)测验信度与结构跨样本一致,说明该测验在两种文化下结构等值;(2)多样本验证性因素分析证明了该测验的测量单位等值性.因此,SON-R 6-40适合在中国推广使用以及用于智力的跨文化比较研究.

  12. Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer.

    Science.gov (United States)

    Madden, Julie M; Mueller, Kelly L; Bollig-Fischer, Aliccia; Stemmer, Paul; Mattingly, Raymond R; Boerner, Julie L

    2014-09-01

    Triple-negative breast cancer (TNBC) patients suffer from a highly malignant and aggressive disease. They have a high rate of relapse and often develop resistance to standard chemotherapy. Many TNBCs have elevated epidermal growth factor receptor (EGFR) but are resistant to EGFR inhibitors as monotherapy. In this study, we sought to find a combination therapy that could sensitize TNBC to EGFR inhibitors. Phospho-mass spectrometry was performed on the TNBC cell line, BT20, treated with 0.5 μM gefitinib. Immunoblotting measured protein levels and phosphorylation. Colony formation and growth assays analyzed the treatment on cell proliferation, while MTT assays determined the synergistic effect of inhibitor combination. A Dual-Luciferase reporter gene plasmid measured translation. All statistical analysis was done on CalucuSyn and GraphPad Prism using ANOVAs. Phospho-proteomics identified the mTOR pathway to be of interest in EGFR inhibitor resistance. In our studies, combining gefitinib and temsirolimus decreased cell growth and survival in a synergistic manner. Our data identified eIF4B, as a potentially key fragile point in EGFR and mTOR inhibitor synergy. Decreased eIF4B phosphorylation correlated with drops in growth, viability, clonogenic survival, and cap-dependent translation. Taken together, these data suggest EGFR and mTOR inhibitors abrogate growth, viability, and survival via disruption of eIF4B phosphorylation leading to decreased translation in TNBC cell lines. Further, including an mTOR inhibitor along with an EGFR inhibitor in TNBC with increased EGFR expression should be further explored. Additionally, translational regulation may play an important role in regulating EGFR and mTOR inhibitor synergy and warrant further investigation.

  13. Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung

    Science.gov (United States)

    Vega-Carrascal, Isabel; Bergin, David A.; McElvaney, Oliver J.; McCarthy, Cormac; Banville, Nessa; Pohl, Kerstin; Hirashima, Mitsuomi; Kuchroo, Vijay K.; Reeves, Emer P.; McElvaney, Noel G.

    2016-01-01

    The T cell Ig and mucin domain–containing molecule (TIM) family of receptors have emerged as potential therapeutic targets to correct abnormal immune function in chronic inflammatory conditions. TIM-3 serves as a functional receptor in structural cells of the airways and via the ligand galectin-9 (Gal-9) can modulate the inflammatory response. The aim of this study was to investigate TIM-3 expression and function in neutrophils, focusing on its potential role in cystic fibrosis (CF) lung disease. Results revealed that TIM-3 mRNA and protein expression values of circulating neutrophils were equal between healthy controls (n = 20) and people with CF (n = 26). TIM-3 was detected on resting neutrophil membranes by FACS analysis, and expression levels significantly increased post IL-8 or TNF-α exposure (p < 0.05). Our data suggest a novel role for TIM-3/Gal-9 signaling involving modulation of cytosolic calcium levels. Via TIM-3 interaction, Gal-9 induced neutrophil degranulation and primed the cell for enhanced NADPH oxidase activity. Killing of Pseudomonas aeruginosa was significantly increased upon bacterial opsonization with Gal-9 (p < 0.05), an effect abrogated by blockade of TIM-3 receptors. This mechanism appeared to be Gram-negative bacteria specific and mediated via Gal-9/ LPS binding. Additionally, we have demonstrated that neutrophil TIM-3/Gal-9 signaling is perturbed in the CF airways due to proteolytic degradation of the receptor. In conclusion, results suggest a novel neutrophil defect potentially contributing to the defective bacterial clearance observed in the CF airways and suggest that manipulation of the TIM-3 signaling pathway may be of therapeutic value in CF, preferably in conjunction with antiprotease treatment. PMID:24477913

  14. TGF-β1 induced epithelial to mesenchymal transition (EMT in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids

    Directory of Open Access Journals (Sweden)

    Zuraw Bruce L

    2009-10-01

    Full Text Available Abstract Background Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling are poorly understood, and there is increasing evidence that even aggressive anti-inflammatory therapy does not completely prevent this process. We sought to investigate whether TGFβ1 stimulates bronchial epithelial cells to undergo transition to a mesenchymal phenotype, and whether this transition can be abrogated by corticosteroid treatment or enhanced by the pro-inflammatory cytokine IL-1β. Methods BEAS-2B and primary normal human bronchial epithelial cells were stimulated with TGFβ1 and expression of epithelial and mesenchymal markers assessed by quantitative real-time PCR, immunoblotting, immunofluorescence microscopy and zymography. In some cases the epithelial cells were also incubated with corticosteroids or IL-1β. Results were analyzed using non-parametric statistical tests. Results Treatment of BEAS-2B or primary human bronchial epithelial cells with TGFβ1 significantly reduced the expression level of the epithelial adherence junction protein E-cadherin. TGFβ1 then markedly induced mesenchymal marker proteins such as collagen I, tenascin C, fibronectin and α-smooth muscle actin mRNA in a dose dependant manner. The process of mesenchymal transition was accompanied by a morphological change towards a more spindle shaped fibroblast cell type with a more motile and invasive phenotype. Corticosteroid pre-treatment did not significantly alter the TGFβ1 induced transition but IL-1β enhanced the transition. Conclusion Our results indicate, that TGFβ1 can induce mesenchymal transition in the bronchial epithelial cell line and primary cells. Since asthma has been strongly associated with increased expression of TGFβ1 in the airway, epithelial to mesenchymal transition may contribute to the contractile and fibrotic remodeling process that accompanies chronic asthma.

  15. A Combination Supplement of Fructo- and Xylo-Oligosaccharides Significantly Abrogates Oxidative Impairments and Neurotoxicity in Maternal/Fetal Milieu Following Gestational Exposure to Acrylamide in Rat.

    Science.gov (United States)

    Krishna, Gokul; Divyashri, Gangaraju; Prapulla, S G; Muralidhara

    2015-09-01

    Prebiotic oligosaccharides are demonstrated to confer a wide spectrum of physiological benefits during pregnancy. In view of this, focused attempts are being directed towards understanding their role as modulators of brain chemistry and behavior. Epidemiological studies have identified that exposure to neurotoxins during prenatal/early life can profoundly impact neurodevelopment/function. In this context, we have tested the hypothesis that a combination of prebiotic supplements during gestation has the propensity to attenuate acrylamide (ACR) induced oxidative impairments, mitochondrial dysfunction and neurotoxicity in maternal and fetal brain of rats. To achieve this, pregnant dams given oral supplements of a combination of fructo- and xylooligosaccharides (FOS + XOS, 3 g/kg/day) during gestation days (GD 0-19) were exposed to ACR (200 ppm in drinking water, GD 6-19). The behavioral analysis revealed that ACR dams fed prebiotics displayed higher exploratory behavior in the open field test. The prenatal evaluation showed that ACR-induced decrements of placental/fetal weights were markedly restored with prebiotic feeding. Prebiotics significantly offset markers of oxidative stress, restored enzymic antioxidants, cholinergic and mitochondrial function in the maternal and fetal brain. Concomitantly, prebiotics restored ACR-induced depletion in the levels of dopamine and γ-aminobutyric acid in the maternal cortex that positively correlated with cecal bacterial numbers. Collectively, these data suggest that prenatal prebiotic oligosaccharide supplements protect developing brain against oxidative stress-mediated neurotoxicity. While the underlying mechanism/s by which prebiotics abrogate the impact of neurotoxicants in the developing brain merits further studies, we speculate that it may be mediated predominantly through attenuation of oxidative stress and proliferation of enteric microbiota. PMID:26248513

  16. Chitosan-shelled oxygen-loaded nanodroplets abrogate hypoxia dysregulation of human keratinocyte gelatinases and inhibitors: New insights for chronic wound healing

    Energy Technology Data Exchange (ETDEWEB)

    Khadjavi, Amina [Dipartimento di Neuroscienze, Università di Torino, Torino (Italy); Magnetto, Chiara [Istituto Nazionale di Ricerca Metrologica (INRIM), Torino (Italy); Panariti, Alice [Dipartimento di Scienze della Salute, Università di Milano Bicocca, Monza (Italy); Argenziano, Monica [Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Torino (Italy); Gulino, Giulia Rossana [Dipartimento di Oncologia, Università di Torino, Torino (Italy); Rivolta, Ilaria [Dipartimento di Scienze della Salute, Università di Milano Bicocca, Monza (Italy); Cavalli, Roberta [Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Torino (Italy); Giribaldi, Giuliana [Dipartimento di Oncologia, Università di Torino, Torino (Italy); Guiot, Caterina [Dipartimento di Neuroscienze, Università di Torino, Torino (Italy); Prato, Mauro, E-mail: mauro.prato@unito.it [Dipartimento di Neuroscienze, Università di Torino, Torino (Italy); Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Università di Torino, Torino (Italy)

    2015-08-01

    Background: : In chronic wounds, efficient epithelial tissue repair is hampered by hypoxia, and balances between the molecules involved in matrix turn-over such as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are seriously impaired. Intriguingly, new oxygenating nanocarriers such as 2H,3H-decafluoropentane-based oxygen-loaded nanodroplets (OLNs) might effectively target chronic wounds. Objective: : To investigate hypoxia and chitosan-shelled OLN effects on MMP/TIMP production by human keratinocytes. Methods: : HaCaT cells were treated for 24 h with 10% v/v OLNs both in normoxia or hypoxia. Cytotoxicity and cell viability were measured through biochemical assays; cellular uptake by confocal microscopy; and MMP and TIMP production by enzyme-linked immunosorbent assay or gelatin zymography. Results: : Normoxic HaCaT cells constitutively released MMP-2, MMP-9, TIMP-1 and TIMP-2. Hypoxia strongly impaired MMP/TIMP balances by reducing MMP-2, MMP-9, and TIMP-2, without affecting TIMP-1 release. After cellular uptake by keratinocytes, nontoxic OLNs abrogated all hypoxia effects on MMP/TIMP secretion, restoring physiological balances. OLN abilities were specifically dependent on time-sustained oxygen diffusion from OLN core. Conclusion: : Chitosan-shelled OLNs effectively counteract hypoxia-dependent dysregulation of MMP/TIMP balances in human keratinocytes. Therefore, topical administration of exogenous oxygen, properly encapsulated in nanodroplet formulations, might be a promising adjuvant approach to promote healing processes in hypoxic wounds. - Highlights: • Hypoxia impairs MMP9/TIMP1 and MMP2/TIMP2 balances in HaCaT human keratinocytes. • Chitosan-shelled oxygen-loaded nanodroplets (OLNs) are internalised by HaCaT cells. • OLNs are not toxic to HaCaT cells. • OLNs effectively counteract hypoxia effects on MMP/TIMP balances in HaCaT cells. • OLNs appear as promising and cost-effective therapeutic tools for hypoxic

  17. ¿Son seres humanos los puentes de fábrica?

    Directory of Open Access Journals (Sweden)

    Bauder, E.

    2006-03-01

    éndole cualidades humanas a lo largo de su ciclo vital, a la vez que desempeña el papel de creador, padre, defensor, médico o psicólogo según las situaciones en que se encuentre o los problemas a que se enfrente su puente-hijo. Además, se quiere poner de manifiesto que la abundante utilización de esta metáfora y las correspondencias terminológicas derivadas de ella no son un fenómeno extraño, sino el resultado lógico de la interdisciplinaridad natural entre la técnica constructiva, la medicina (psicología incluida, la terminología y el lenguaje.

  18. TGF-β1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1β but not abrogated by corticosteroids

    OpenAIRE

    Zuraw Bruce L; Doerner Astrid M

    2009-01-01

    Abstract Background Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling are poorly understood, and there is increasing evidence that even aggressive anti-inflammatory therapy does not completely prevent this process. We sought to investigate whether TGFβ1 stimulates bronchial epithelial cells to undergo transition to a mesenchymal phenotype, and whether this transition can be abrogated by corticosteroid tr...

  19. QCD Precision Measurements and Structure Function Extraction at a High Statistics, High Energy Neutrino Scattering Experiment: NuSOnG

    Energy Technology Data Exchange (ETDEWEB)

    Adams, T.; /Florida State U.; Batra, P.; /Columbia U.; Bugel, Leonard G.; /Columbia U.; Camilleri, Leslie Loris; /Columbia U.; Conrad, Janet Marie; /MIT; de Gouvea, A.; /Northwestern U.; Fisher, Peter H.; /MIT; Formaggio, Joseph Angelo; /MIT; Jenkins, J.; /Northwestern U.; Karagiorgi, Georgia S.; /MIT; Kobilarcik, T.R.; /Fermilab /Texas U.

    2009-06-01

    We extend the physics case for a new high-energy, ultra-high statistics neutrino scattering experiment, NuSOnG (Neutrino Scattering On Glass) to address a variety of issues including precision QCD measurements, extraction of structure functions, and the derived Parton Distribution Functions (PDFs). This experiment uses a Tevatron-based neutrino beam to obtain a sample of Deep Inelastic Scattering (DIS) events which is over two orders of magnitude larger than past samples. We outline an innovative method for fitting the structure functions using a parameterized energy shift which yields reduced systematic uncertainties. High statistics measurements, in combination with improved systematics, will enable NuSOnG to perform discerning tests of fundamental Standard Model parameters as we search for deviations which may hint of 'Beyond the Standard Model' physics.

  20. KLEIN (André), David Ortlieb (1797-1875) : un artiste alsacien en son époque

    OpenAIRE

    Esch, Christine

    2013-01-01

    L’Association pour la restauration des édifices historiques de Colmar et son président André Klein font découvrir à travers cette importante monographie l’artiste peintre colmarien singulier qu’est David Ortlieb (1797-1875). Aucun ouvrage conséquent ne lui avait été consacré jusqu’alors : il fallait se contenter d’écrits épars et de sources clairsemées. Au fil des pages, André Klein resitue l’artiste et son œuvre dans le temps et l’espace. Il propose des fragments biographiques agrémentés de ...

  1. QCD Precision Measurements and Structure Function Extraction at a High Statistics, High Energy Neutrino Scattering Experiment: NuSOnG

    CERN Document Server

    Adams, T; Bugel, L; Camilleri, L; Conrad, J M; De Gouvêa, A; Fisher, P H; Formaggio, J A; Jenkins, J; Karagiorgi, G; Kobilarcik, T R; Kopp, S; Kyle, G; Loinaz, W A; Mason, D A; Milner, R; Moore, R; Morfín, J G; Nakamura, M; Naples, D; Nienaber, P; Olness, F I; Owens, J F; Pate, S F; Pronin, A; Seligman, W G; Shaevitz, M H; Schellman, H; Schienbein, I; Syphers, M J; Tait, T M P; Takeuchi, T; Tan, C Y; Van de Water, R G; Yamamoto, R K; Yu, J Y

    2009-01-01

    We extend the physics case for a new high-energy, ultra-high statistics neutrino scattering experiment, NuSOnG (Neutrino Scattering On Glass) to address a variety of issues including precision QCD measurements, extraction of structure functions, and the derived Parton Distribution Functions (PDFs). This experiment uses a Tevatron-based neutrino beam to obtain a sample of Deep Inelastic Scattering (DIS) events which is over two orders of magnitude larger than past samples. We outline an innovative method for fitting the structure functions using a parameterized energy shift which yields reduced systematic uncertainties. High statistics measurements, in combination with improved systematics, will enable NuSOnG to perform discerning tests of fundamental Standard Model parameters as we search for deviations which may hint of "Beyond the Standard Model" physics.

  2. Alteration kinetics of the glass-ceramic zirconolite and role of the alteration film Comparison with the SON68 glass

    Science.gov (United States)

    Martin, C.; Ribet, I.; Frugier, P.; Gin, S.

    2007-06-01

    The glass-ceramic zirconolite is being considered for specific conditioning of plutonium or the minor actinides. The actinides are distributed throughout the zirconolite crystals and the residual glass phase. Since zirconolite alteration is extremely limited, actinide release from the glass-ceramic material is mainly attributable to alteration of the residual glass. Specimens corresponding to the residual glass phase alone were therefore altered under different conditions to compare their kinetics with the one of the SON68 glass (inactive R7T7 type glass). Glass-ceramic zirconolite presents a more important rate decrease occuring more rapidly and that induces a quantity of glass altered at least 10 times as small as for SON68 glass. This slowdown of the alteration rate is attributed to the formation of an alteration film that has been the subject of a specific study. We have in particular identified a dense phase enriched in titanium and neodymium that probably influences deeply the kinetics.

  3. Parents who have lost a son or daughter through suicide : towards improved care and restored psychological health

    OpenAIRE

    Larsson Omerov, Pernilla

    2014-01-01

    Background Parents that have lost a son or daughter through suicide are at risk of developing psychological morbidity that may become long-lasting and even life-threatening. Despite this the aftermath of a suicidal loss is yet to be carefully studied. One reason for the lack of studies is that trauma-related surveys may be hindered when the risks of asking participants are overestimated and the benefits not considered. Another reason is methodological difficulties. The goa...

  4. A Brief Introduction to Paul in Sons and Lovers——From Self-absence to Self-realization

    Institute of Scientific and Technical Information of China (English)

    张灵机

    2008-01-01

    Paul,the main character in the novel Sons and Lovers,experiences a tough psychological development.At the beginning,he relies heavily on his mother and serves as the medium of her dream and ambitions,leading him to a lost self.Whereas,in his attempt,though it is painful,he finally finds a true self of his own maintaining a harmonious unity with various social relations.

  5. Bargaining over Sons and Daughters: Child Labor, School Attendance and Intra-Household Gender Bias in Brazil

    OpenAIRE

    Emerson, Patrick M.; Andre Portela Souza

    2002-01-01

    In this paper we examine intra-household gender differences and the incidence of child labor and children�s school attendance in Brazil to test whether the unitary model of household allocations is suitable in the child labor context. We begin by building an intra-household allocation model where fathers and mothers may affect the education investment and the child labor participation of their sons and daughters differently due to differences in the children's human capital technologies and...

  6. Exploring Mothers’ and Fathers’ Relationships with Sons Versus Daughters: Links to Adolescent Adjustment in Mexican Immigrant Families

    OpenAIRE

    Updegraff, Kimberly A.; Delgado, Melissa Y.; Wheeler, Lorey A.

    2009-01-01

    Drawing on ecological and gender socialization perspectives, this study examined mothers’ and fathers’ relationships with young adolescents, exploring differences between mothers and fathers, for sons versus daughters, and as a function of parents’ division of paid labor. Mexican immigrant families (N = 162) participated in home interviews and seven nightly phone calls. Findings revealed that mothers reported higher levels of acceptance toward adolescents and greater knowledge of adolescents’...

  7. 养儿防老和母以子贵:是儿子还是儿女双全?%Old- age Support and Mother's Family Status. Sons Only or Both Sons and Daughters?

    Institute of Scientific and Technical Information of China (English)

    尹银

    2012-01-01

    了解养儿防老、母以子贵等传统生育文化的影响对中国稳定低生育水平至关重要。使用2008年中国老年人健康因素跟踪调查数据,通过logistic回归分析子女性别对老年父亲、母亲生活质量(包括生活满意度和婚姻满意度)、家庭地位(包括经济决策权和自我决策权)的影响发现,儿子的作用大大下降,儿女双全除了增加老年父亲的婚姻满意度以外,并没有提高老年人的生活质量,养儿未必能防老;生育儿子或儿女双全并没有提高老年母亲的家庭地位,甚至有儿子的老年母亲的经济决策权还更低;老年人自身的社会经济因素显著提高了老年人的生活质量和家庭地位。养儿防老、母以子贵等传统生育文化影响逐渐减弱,这对中国稳定低生育水平是一个利好的消息。%It is important to study the influences of traditional fertility culture (such as old - age sup- port and mother' s status depending on sons) on China's fertility. Using 2008 Chinese Longitudinal Healthy Longevity Survey, the paper analyzes the impact of sex of children on life quality of elderly par- ents (including life satisfaction and marital satisfaction) and family status (including economic decision - making power and self decision - making authority). Regression results show that son' s influence has decreased. Having both sons and daughters does not improve life quality of the elderly parents, but increases marital satisfaction of the elderly fathers. Bringing up sons not necessarily provides sup- port for ageing parents. Having sons or both sons and daughters may not help to improve family status of the elderly mothers, and the elderly mothers having sons only have even lower economic decision - making power. Social and economic situation of the elderly significantly improves their life quality and family status. Thus, influences of traditional fertility culture have been gradually weakening

  8. BALTIMORE’S M.S. LEVY AND SONS: Straw Hat Makers to the World, 1870-1960

    Directory of Open Access Journals (Sweden)

    Jessica I. Elfenbein

    2008-01-01

    Full Text Available From 1860 to 1960, Baltimore was an important center of the men’s ready-to- wear clothing industries. German-speaking Jews created many businesses that manufactured and sold underwear, men’s suits, and specialty items like hats and umbrellas. The straw hat making firm started by M.S. Levy is an interesting example of a Baltimore-based, family-owned niche business that existedfor 90 years, through three generations ofa singlefamily. The M.S. Levy and Sons story has two main chapters. The first covers the period from its founding by Michael Simon Levy in the 1870s through his son Julius’ death in 1926. This is the story of ascension. A premonition about the coming popularity of straw hats, together with a small but important technological breakthrough, positioned a family and a small industry for significant expansion. The second period began in 1930 with the introduction of wool felt hats and the death of William, M.S. Levy’s oldest son, and includes the Great Depression, unionization, merger, third generation leadership, and finally, in 1959, the family’s withdrawal from the industry. This later period, as told by grandsons of the founder, is the story of struggle followed by decline.

  9. Mothers, fathers, sons, and daughters: gender differences in factors associated with parent-child communication about sexual topics

    Directory of Open Access Journals (Sweden)

    Koo Helen P

    2010-12-01

    Full Text Available Abstract Background In the United States, nearly half of high school students are sexually active, and adolescents experience high rates of unintended pregnancy and sexually transmitted diseases. Parents can have an important influence on their children's sexual behaviour, but many parents do not talk with their children about sexual topics. Research has shown significant differences in parent-child communication about sexual topics depending on the gender of both the parent and the child. Little is known, however, about the reasons for these gender differences. The purpose of this paper is to describe how factors associated with parent-child communication about sexual topics differ by gender. Methods Data are from a nationwide online survey with 829 fathers and 1,113 mothers of children aged 10 to 14. For each of the four gender groups (fathers of sons, fathers of daughters, mothers of sons, mothers of daughters, we calculated the distribution of responses to questions assessing (1 parent-child communication about sex-related topics, and (2 factors associated with that communication. We used chi-square tests to determine whether the distributions differed and the false discovery rate control to reduce the likelihood of type I errors. Results With both sons and daughters, fathers communicated less about sexual topics than mothers did. Fathers also had lower levels of many characteristics that facilitate communication about sex (e.g., lower self-efficacy and lower expectations that talking to their children about sex would have positive outcomes. Compared with parents of sons, parents of daughters (both mothers and fathers talked more about sexual topics, were more concerned about potential harmful consequences of sexual activity, and were more disapproving of their child having sex at an early age. Conclusions Using a large national sample, this study confirms findings from previous studies showing gender differences in parent

  10. Effect of Callovo-Oxfordian clay rock on the dissolution rate of the SON68 simulated nuclear waste glass

    Energy Technology Data Exchange (ETDEWEB)

    Neeway, James J., E-mail: James.Neeway@pnnl.gov [SUBATECH, Unité Mixte de Recherche 6457, École des Mines de Nantes, CNRS/IN2P3, Université de Nantes, BP 20722, 44307 Nantes cedex 3 (France); Abdelouas, Abdesselam; Ribet, Solange; El Mendili, Yassine [SUBATECH, Unité Mixte de Recherche 6457, École des Mines de Nantes, CNRS/IN2P3, Université de Nantes, BP 20722, 44307 Nantes cedex 3 (France); Schumacher, Stéphan [ANDRA, Parc de la Croix Blanche, 1/7 rue Jean Monnet, 92298 Châtenay-Malabry (France); Grambow, Bernd [SUBATECH, Unité Mixte de Recherche 6457, École des Mines de Nantes, CNRS/IN2P3, Université de Nantes, BP 20722, 44307 Nantes cedex 3 (France)

    2015-04-15

    Long-term storage of high-level nuclear waste glass in France is expected to occur in an engineered barrier system (EBS) located in a subsurface Callovo-Oxfordian (COx) clay rock formation in the Paris Basin in northeastern France. Understanding the behavior of glass dissolution in the complex system is critical to be able to reliably model the performance of the glass in this complex environment. To simulate this multi-barrier repository scenario in the laboratory, several tests have been performed to measure glass dissolution rates of the simulated high-level nuclear waste glass, SON68, in the presence of COx claystone at 90 °C. Experiments utilized a High-Performance Liquid Chromatography (HPLC) pump to pass simulated Bure site COx pore water through a reaction cell containing SON68 placed between two COx claystone cores for durations up to 200 days. Silicon concentrations at the outlet were similar in all experiments, even the blank experiment with only the COx claystone (∼4 mg/L at 25 °C and ∼15 mg/L at 90 °C). The steady-state pH of the effluent, measured at room temperature, was roughly 7.1 for the blank and 7.3–7.6 for the glass-containing experiments demonstrating the pH buffering capacity of the COx claystone. Dissolution rates for SON68 in the presence of the claystone were elevated compared to those obtained from flow-through experiments conducted with SON68 without claystone in silica-saturated solutions at the same temperature and similar pH values. Additionally, through surface examination of the monoliths, the side of the monolith in direct contact with the claystone was seen to have a corrosion thickness 2.5× greater than the side in contact with the bulk glass powder. Results from one experiment containing {sup 32}Si-doped SON68 also suggest that the movement of Si through the claystone is controlled by a chemically coupled transport with a Si retention factor, K{sub d}, of 900 mL/g.

  11. Depo-provera treatment does not abrogate protection from intravenous SIV challenge in female macaques immunized with an attenuated AIDS virus.

    Directory of Open Access Journals (Sweden)

    Meritxell Genescà

    Full Text Available BACKGROUND: In a previous study, progesterone treatment of female monkeys immunized with live, attenuated SHIV89.6 abrogated the generally consistent protection from vaginal simian immunodeficiency virus (SIV challenge. The mechanisms responsible for the loss of protection remain to be defined. The objective of the present study was to determine whether Depo-Provera administration alters protection from intravenous SIV challenge in SHIV-immunized female macaques. METHODS AND FINDINGS: Two groups of female macaques were immunized with attenuated SHIV89.6 and then challenged intravenously with SIVmac239. Four weeks before challenge, one animal group was treated with Depo-Provera, a commonly used injectable contraceptive progestin. As expected, SHIV-immunized monkeys had significantly lower peak and set-point plasma viral RNA levels compared to naïve controls, but in contrast to previously published findings with vaginal SIV challenge, the Depo-Provera SHIV-immunized animals controlled SIV replication to a similar, or even slightly greater, degree than did the untreated SHIV-immunized animals. Control of viral replication from week 4 to week 20 after challenge was more consistent in the progesterone-treated, SHIV-immunized animals than in untreated, SHIV-immunized animals. Although levels of interferon-gamma production were similar, the SIV-specific CD8(+ T cells of progesterone-treated animals expressed more functions than the anti-viral CD8(+ T cells from untreated animals. CONCLUSIONS: Depo-Provera did not diminish the control of viral replication after intravenous SIV challenge in female macaques immunized with a live-attenuated lentivirus. This result contrasts with the previously reported effect of Depo-Provera(R on protection from vaginal SIV challenge and strongly implies that the decreased protection from vaginal challenge is due to effects of progesterone on the genital tract rather than to systemic effects. Further, these results

  12. NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL

    International Nuclear Information System (INIS)

    Highlights: •NS1 induced excessive phosphorylation of ERK and elevated cell viability. •NS1-BP expression and CRKL knockdown abolished survival effect of NS1. •NS1-BP and NS1 formed the complex through the interaction with CRKL-SH3(N). -- Abstract: The influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor consisting of an RNA binding domain and several Src-homology (SH) 2 and SH3 binding motifs, which promotes virus replication in the host cell and helps to evade antiviral immunity. NS1 modulates general host cell physiology in association with various cellular molecules including NS1-binding protein (NS1-BP) and signaling adapter protein CRK-like (CRKL), while the physiological role of NS1-BP during influenza A virus infection especially in association with NS1 remains unclear. In this study, we analyzed the intracellular association of NS1-BP, NS1 and CRKL to elucidate the physiological roles of these molecules in the host cell. In HEK293T cells, enforced expression of NS1 of A/Beijing (H1N1) and A/Indonesia (H5N1) significantly induced excessive phosphorylation of ERK and elevated cell viability, while the over-expression of NS1-BP and the abrogation of CRKL using siRNA abolished such survival effect of NS1. The pull-down assay using GST-fusion CRKL revealed the formation of intracellular complexes of NS1-BP, NS1 and CRKL. In addition, we identified that the N-terminus SH3 domain of CRKL was essential for binding to NS1-BP using GST-fusion CRKL-truncate mutants. This is the first report to elucidate the novel function of NS1-BP collaborating with viral protein NS1 in modulation of host cell physiology. In addition, an alternative role of adaptor protein CRKL in association with NS1 and NS1-BP during influenza A virus infection is demonstrated

  13. Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

    Science.gov (United States)

    Sampieri, Clara L; Nuttall, Robert K; Young, David A; Goldspink, Deborah; Clark, Ian M; Edwards, Dylan R

    2008-03-01

    The human matrix metalloproteinase (MMP) gene family includes 24 genes whose regulated expression, together with that of four tissue inhibitors of metalloproteinases (TIMPs), is essential in tissue remodelling and cell signalling. Quantitative real-time-PCR (qPCR) analysis was used to evaluate the shared and unique patterns of control of these two gene families in human MRC-5 and WI-38 fibroblasts in response to the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA). The requirement for ongoing translation was analysed using three protein synthesis inhibitors, anisomycin, cycloheximide and emetine. PMA induced MMP1, 3, 8, 9, 10, 12, 13, 14 and TIMP1 and TIMP3 RNAs after 4-8 h, and induction of all except MMP9 and TIMP3 was blocked by all protein synthesis inhibitors. However, even though all inhibitors effectively blocked translation, PMA-induction of MMP9 and TIMP3 was blocked by emetine but was insensitive to cycloheximide and anisomycin. Anisomycin alone induced MMP9 and TIMP3, along with MMP25 and MMP19. The extracellular signal-regulated kinases (ERKs)-1/2 were strongly activated by PMA, while anisomycin activated the c-Jun N-terminal kinase (JNK) and p38 pathways, and cycloheximide activated p38, but emetine had no effect on the stress-activated mitogen-activated protein kinase (MAPK) pathways. The involvement of the p38 and JNK pathways in the selective effects of anisomycin and cycloheximide on MMP/TIMP expression was supported by use of pharmacological inhibitors. These data confirm that most inducible MMPs and TIMP1 behave as "late" activated, protein synthesis-dependent genes in fibroblasts. However, the requirement of protein synthesis for PMA-induction of MMPs and TIMPs is not universal, since it is abrogated for MMP9 and TIMP3 by stimulation of the stress-activated MAPK pathways. The definition of clusters of co-regulated genes among the two gene families will aid in bioinformatic dissection of control mechanisms.

  14. NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL

    Energy Technology Data Exchange (ETDEWEB)

    Miyazaki, Masaya [Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638 (Japan); Nishihara, Hiroshi, E-mail: hnishihara@med.hokudai.ac.jp [Department of Translational Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638 (Japan); Hasegawa, Hideki [Department of Pathology, National Institute of Infectious Diseases, Sinjuku-ku, Tokyo (Japan); Tashiro, Masato [Influenza Virus Research Center, National Institute of Infectious Diseases, Sinjuku-ku, Tokyo (Japan); Wang, Lei [Department of Translational Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638 (Japan); Kimura, Taichi; Tanino, Mishie; Tsuda, Masumi [Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638 (Japan); Tanaka, Shinya [Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638 (Japan); Department of Translational Pathology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638 (Japan)

    2013-11-29

    Highlights: •NS1 induced excessive phosphorylation of ERK and elevated cell viability. •NS1-BP expression and CRKL knockdown abolished survival effect of NS1. •NS1-BP and NS1 formed the complex through the interaction with CRKL-SH3(N). -- Abstract: The influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor consisting of an RNA binding domain and several Src-homology (SH) 2 and SH3 binding motifs, which promotes virus replication in the host cell and helps to evade antiviral immunity. NS1 modulates general host cell physiology in association with various cellular molecules including NS1-binding protein (NS1-BP) and signaling adapter protein CRK-like (CRKL), while the physiological role of NS1-BP during influenza A virus infection especially in association with NS1 remains unclear. In this study, we analyzed the intracellular association of NS1-BP, NS1 and CRKL to elucidate the physiological roles of these molecules in the host cell. In HEK293T cells, enforced expression of NS1 of A/Beijing (H1N1) and A/Indonesia (H5N1) significantly induced excessive phosphorylation of ERK and elevated cell viability, while the over-expression of NS1-BP and the abrogation of CRKL using siRNA abolished such survival effect of NS1. The pull-down assay using GST-fusion CRKL revealed the formation of intracellular complexes of NS1-BP, NS1 and CRKL. In addition, we identified that the N-terminus SH3 domain of CRKL was essential for binding to NS1-BP using GST-fusion CRKL-truncate mutants. This is the first report to elucidate the novel function of NS1-BP collaborating with viral protein NS1 in modulation of host cell physiology. In addition, an alternative role of adaptor protein CRKL in association with NS1 and NS1-BP during influenza A virus infection is demonstrated.

  15. Review of the execution of the extension of the Sonček kindergarten in Semič project

    OpenAIRE

    Konda, Anja

    2012-01-01

    The thesis demonstrates a review of the running of the project titled The Extension of the Sonček Kindergarten in Semič. The author of the thesis monitored the course of the construction work up to the completion of its third phase. First, the organisation of the project and the conditions for the construction have been demonstrated. What follows is the presentation of the organisation of the technological construction process: it describes the methods of executing the individual phases of co...

  16. Indicadores regionales de desarrollo sustentable en Chile: ¿Hasta qué punto son útiles y necesarios?

    Directory of Open Access Journals (Sweden)

    Hernán Blanco

    2001-09-01

    Full Text Available Cada vez más necesitamos maneras de asegurar patrones de desarrollo que sean sustentables, es decir, que sean ambiental, social y económicamente apropiados para nosotros y para las generaciones venideras. Los indicadores de desarrollo sustentable son una herramienta promisoria que permitiría "aterrizar" el concepto de sustentabilidad, apoyando la manera en que se toman las decisiones. En Chile existen pocas experiencias sobre el tema. Este artículo presenta el trabajo realizado para desarrollar indicadores de desarrollo sustentable en cuatro regiones del país. El artículo se centra en las lecciones que han surgido de la experiencia

  17. Hamlet på motorcyklar : En komparativ analys av TV-serien Sons of Anarchy och Shakespeares drama Hamlet

    OpenAIRE

    Sander, Johanna

    2010-01-01

    In 2008 Fox first aired its hit show Sons of Anarchy, a drama series about a Californian motorcycle club. The main thrust is about the club’s vice-president and his struggle to find his place in a life of violence. According to creator Kurt Sutter the series is partly based on Shakespeare’s 16th century drama Hamlet - Prince of Denmark, which causes the show to often be referred to as ”Hamlet on Harleys”. Focusing on the first two seasons of the series, this essay looks into the relationship ...

  18. Cirugía cardiaca en el hospital universitario Son Dureta: Análisis de morbimortalidad y factores asociados

    OpenAIRE

    Riera Sagrera, María

    2011-01-01

    La morbimortalidad de la cirugía cardiaca y el análisis de los factores pronósticos muestran resultados discrepantes. Se analizaron las complicaciones postoperatorias y la mortalidad hospitalaria y a medio plazo, en relación con la edad y otros factores de riesgo asociados. Se realizó en el hospital universitario Son Dureta (Palma de Mallorca), con una unidad de cuidados intensivos específica para dicho paciente. La mortalidad hospitalaria y a medio plazo fue menor, comparada con otras series...

  19. "Daughter and son: a completely different story”? Gender as a moderator of the relationship between sexism and parental attitudes

    Directory of Open Access Journals (Sweden)

    Małgorzata Lipowska

    2016-09-01

    Full Text Available Background During childhood, parents are the first and most important individuals who form the base of the content of gender stereotypes in children. A parent’s expectations about the extent a child’s behaviour should be line with gender stereotypes also depends on the intensity of a parent’s sexism. A parent’s sexism may be exhibited in parental attitudes. Hence, in our study we analysed the relationship between parental ambivalent sexism and parental attitudes within dyads of mothers and fathers with a special focus on the role of the gender of both parents and children. Participants and procedure Two hundred and ninety-four couples of parents of five-year-olds (153 girls, 141 boys participated. The Ambivalent Sexism Inventory (ASI was used to measure levels of sexism, and the Parental Attitudes Scale (SPR was used to assess parental attitudes. Results In terms of the profile of parental attitudes, regardless of the child’s sex, mothers and fathers scored highest for inconsequent and demanding attitudes, and lowest for overprotective and autonomy attitudes. The child’s sex is also not important for the overall levels of parents’ sexism – fathers exhibit higher levels of hostile sexism in comparison to mothers. Only the mothers’ education level is important for levels of sexism – women with higher education exhibited the lowest levels of hostile sexism. The child’s sex moderates relationships between parents’ sexism and parental attitudes. In the case of mothers of sons, the intensity of benevolent sexism is negatively related to overprotective and demanding attitudes. The more educated the mothers of sons, the more demanding they were. For fathers of sons, the inconsequence attitude increases under the influence of both hostile and benevolent sexism. Among fathers of daughters, hostile sexism strengthens the overprotective attitude, while levels of both benevolent and hostile sexism as well as education influence the

  20. ¿SON LOS PADRES Y PROFESORES BUENOS DETECTORES DE LAS ALTAS CAPACIDADES INTELECTUALES DE LOS ALUMNOS?

    OpenAIRE

    Fernández-Sánchez, Inmaculada

    2013-01-01

    Los alumnos con altas capacidades intelectuales son una población con posibles dificultades adaptativas a la escuela, ya que un porcentaje elevado de ellos presentan un síndrome de bajo rendimiento, debido, entre otras cosas, a sus características psiconeurológicas y a la falta de formación del profesorado para identificarlos y para intervenir con las medidas educativas apropiadas. Este trabajo tiene como objetivo conocer la adecuación de los procesos de identificación de al...

  1. IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells

    OpenAIRE

    Chen, Xiaoli; Zheng, Junke; Zou, Yizhou; Song, Chun; Hu, Xuemei; Zhang, Cheng Cheng

    2013-01-01

    Background The role of IGF binding protein 2 (IGFBP2) in cancer development is intriguing. Previously we identified IGFBP2 as an extrinsic factor that supports the activity of hematopoietic stem cells (HSCs). Methods and results Here we investigated the role of IGFBP2 in in human leukemia cells and in the retroviral AML1-ETO9a transplantation acute myeloid leukemia (AML) mouse model. Results IGFBP2 is highly expressed in certain human AML and acute lymphoblastic leukemia (ALL) cells. Inhibiti...

  2. Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells

    Directory of Open Access Journals (Sweden)

    Furukawa Toru

    2012-12-01

    Full Text Available Abstract Background Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase (MAPK. Activation of MAPK is associated with the upregulation of genes implicated in the proliferation and survival of pancreatic cancer cells. We hypothesized that knockdown of these MAPK-associated molecules could produce notable anticancer phenotypes. Methods A RNA interference-mediated knockdown screening of 78 MAPK-associated molecules previously identified was performed to find molecules specifically associated with proliferation of pancreatic cancer cells in vitro. Expression of an identified molecule in pancreatic cancer tissues was examined by immunohistochemistry. In vivo tumorigenicity of cancer cells with stable knockdown of the molecule was assayed by using xenograft models. Flow cytometry and live cell imaging were employed to assess an association of the molecule with cell cycle. Results The knockdown screening revealed that knockdown of SON, the gene encoding SON, which is a large serine/arginine-rich protein involved in RNA processing, substantially suppressed pancreatic cancer cell proliferation and survival in vitro and tumorigenicity in vivo. SON expression was higher in ductal adenocarcinomas than in cells of normal ducts and precursor lesions in pancreatic cancer tissues. Knockdown of SON induced G2/M arrest and apoptosis in cultured cancer cells. The suppressive effect of SON knockdown on proliferation was less pronounced in cultured normal duct epithelial cells. SON formed nuclear speckles in the interphase of the cell cycle and dispersed in the cytoplasm during mitosis. Live cell imaging showed that SON diffusely dispersed in the early mitotic phase, accumulated in some foci in the cytoplasm in the late mitotic phase, and gradually reassembled into speckles after mitosis. Conclusion These results indicate that SON plays a critical role in the proliferation, survival, and tumorigenicity of pancreatic

  3. Expression of Multiple Sexual Signals by Fathers and Sons in the East-Mediterranean Barn Swallow: Are Advertising Strategies Heritable?

    Science.gov (United States)

    Vortman, Yoni; Safran, Rebecca J.; Reiner Brodetzki, Tali; Dor, Roi; Lotem, Arnon

    2015-01-01

    The level of expression of sexually selected traits is generally determined by genes, environment and their interaction. In species that use multiple sexual signals which may be costly to produce, investing in the expression of one sexual signal may limit the expression of the other, favoring the evolution of a strategy for resource allocation among signals. As a result, even when the expression of sexual signals is condition dependent, the relative level of expression of each signal may be heritable. We tested this hypothesis in the East-Mediterranean barn swallow (Hirundo rustica transitiva), in which males have been shown to express two uncorrelated sexual signals: red-brown ventral coloration, and long tail streamers. We show that variation in both signals may partially be explained by age, as well as by paternal origin (genetic father-son regressions), but that the strongest similarity between fathers and sons is the relative allocation towards one trait or the other (relative expression index), rather than the expression of the traits themselves. These results suggest that the expression of one signal is not independent of the other, and that genetic strategies for resource allocation among sexual signals may be selected for during the evolution of multiple sexual signals. PMID:25679206

  4. Expression of multiple sexual signals by fathers and sons in the East-Mediterranean barn swallow: are advertising strategies heritable?

    Directory of Open Access Journals (Sweden)

    Yoni Vortman

    Full Text Available The level of expression of sexually selected traits is generally determined by genes, environment and their interaction. In species that use multiple sexual signals which may be costly to produce, investing in the expression of one sexual signal may limit the expression of the other, favoring the evolution of a strategy for resource allocation among signals. As a result, even when the expression of sexual signals is condition dependent, the relative level of expression of each signal may be heritable. We tested this hypothesis in the East-Mediterranean barn swallow (Hirundo rustica transitiva, in which males have been shown to express two uncorrelated sexual signals: red-brown ventral coloration, and long tail streamers. We show that variation in both signals may partially be explained by age, as well as by paternal origin (genetic father-son regressions, but that the strongest similarity between fathers and sons is the relative allocation towards one trait or the other (relative expression index, rather than the expression of the traits themselves. These results suggest that the expression of one signal is not independent of the other, and that genetic strategies for resource allocation among sexual signals may be selected for during the evolution of multiple sexual signals.

  5. (Alpha, gamma) irradiation effect on the alteration of high-level radioactive wastes matrices (UO2, hollandite, glass SON68)

    International Nuclear Information System (INIS)

    The aim of this work is to determine the effect of irradiation on the alteration of high level nuclear waste forms matrices. The matrices investigated are UO2 to simulate the spent fuel, the hollandite for the specific conditioning of Cs, and the inactive glass SON68 representing the nuclear glass R7T7) The alpha irradiation experiments on UO2 colloids in aqueous carbonate media have enabled to distinguish between the oxidation of UO2 matrix as initial and dissolution as subsequent step. The simultaneous presence of carbonate and H2O2 (product resulting from water radiolysis) increased the dissolution rate of UO2 to its maximum value governed by the oxidation rate. ii) The study of hollandite alteration under gamma irradiation confirmed the good retention capacity for Cs and Ba. Gamma irradiation had brought only a little influence on releasing of Cs and Ba in solution. Electronic irradiation had conducted to the amorphization of the hollandite only for a dose 1000 times higher than the auto-induced dose of Ba over millions of years. iii) The experiences of glass irradiation under alpha beam and of helium implantation in the glass SON68 were analyzed by positon annihilation spectroscopy. No effect has been observed on the solid surface for an irradiation dose equal to 1000 years of storage. (author)

  6. Aging parents' caregiving and rehabilitating a brain-injured son: an autoethnography of a 10-year journey.

    Science.gov (United States)

    Hassan, Syed Tajuddin Syed; Jamaludin, Husna

    2014-01-01

    This autoethnography withdraws from information accumulated through a 10-year period of daily-weekly-monthly descriptive observation-recording (triangulated- parents & house-helper) of caregiving and rehabilitating of our brain injured son (survivor/care-receiver). We present it as an interactive voice of verbal conversation, thoughts, insights, and interpretations. It is delivered as a series of articulation intra-pulsated with our interrogation of societal-cultural-religious perspectives, norms and biases, and aligns with the CAP (Creative Analytical Practices) method of Ellis. This autoethnography glows from the richness of information which encapsulates the challenges confronting us the aging parent caregivers, the gradual incremental mind mending achievement of our son, and the interactive verbalizations and thoughts, of the caregivers, care-receiver, and other persons. The overwhelming mental and physical pain and struggle of the survivor and the aging caregivers and their sense of celebratory-satisfaction with rehabilitation progress are highlighted. Interpretation and valuation of positive and negative responses of other persons provide a critical matrix to this autoethnography. We intend to inform other caregivers and relevant healthcare professionals through this autoethnography. PMID:25763170

  7. When mothers make sons sexy: maternal effects contribute to the increased sexual attractiveness of extra-pair offspring.

    Science.gov (United States)

    Tschirren, Barbara; Postma, Erik; Rutstein, Alison N; Griffith, Simon C

    2012-03-22

    Quality differences between offspring sired by the social and by an extra-pair partner are usually assumed to have a genetic basis, reflecting genetic benefits of female extra-pair mate choice. In the zebra finch (Taeniopygia guttata), we identified a colour ornament that is under sexual selection and appears to have a heritable basis. Hence, by engaging in extra-pair copulations with highly ornamented males, females could, in theory, obtain genes for increased offspring attractiveness. Indeed, sons sired by extra-pair partners had larger ornaments, seemingly supporting the genetic benefit hypothesis. Yet, when comparing ornament size of the social and extra-pair partners, there was no difference. Hence, the observed differences most likely had an environmental basis, mediated, for example, via differential maternal investment of resources into the eggs fertilized by extra-pair and social partners. Such maternal effects may (at least partly) be mediated by egg size, which we found to be associated with mean ornament expression in sons. Our results are consistent with the idea that maternal effects can shape sexual selection by altering the genotype-phenotype relationship for ornamentation. They also caution against automatically attributing greater offspring attractiveness or viability to an extra-pair mate's superior genetic quality, as without controlling for differential maternal investment we may significantly overestimate the role of genetic benefits in the evolution of extra-pair mating behaviour. PMID:21957136

  8. Application of the GRAAL model to leaching experiments with SON68 nuclear glass in initially pure water

    Energy Technology Data Exchange (ETDEWEB)

    Frugier, P., E-mail: pierre.frugier@cea.f [CEA Marcoule, DTCD/SECM/LCLT, BP 17171, 30207 Bagnols-sur-Ceze Cedex (France); Chave, T. [ICSM Site de Marcoule, DEN/MAR/ICSM/LSFC, UMR 5257, BP 17171, 30207 Bagnols-sur-Ceze Cedex (France); Gin, S. [CEA Marcoule, DTCD/SECM/LCLT, BP 17171, 30207 Bagnols-sur-Ceze Cedex (France); Lartigue, J.-E. [CEA Cadarache, DEN/CAD/DTN/SMTM/LMTE, 13108 Saint-Paul-Lez-Durance Cedex (France)

    2009-08-01

    Based on a review of the current state of knowledge concerning the aqueous alteration of SON68 nuclear glass we have proposed a mechanistic model, GRAAL (Glass Reactivity with Allowance for the Alteration Layer) [P. Frugier, S. Gin, Y. Minet, T. Chave, B. Bonin, N. Godon, J.E. Lartigue, P. Jollivet, A. Ayral, L. De Windt, G. Santarini, J. Nucl. Mater. 380 (2008) 8]. This article describes how the GRAAL model hypotheses are solved using a calculation code coupling chemistry and transport. The geochemical solution of this model combines three major phenomena: chemical equilibria in solution, water and ion transport by convection or diffusion, and element diffusion through the passivating reactive interphase. The model results are compared with experimental data for SON68 glass leached in initially pure water both in a closed system and in renewed media. The comparison shows the model very satisfactorily accounts for variations in the pH and the element concentrations in solution as a function of time, the glass surface area in contact with solution, and the solution renewal rate. This success is due to the fact that the diffusion of elements through the alteration gel is taken into account in the model. This mechanism cannot be disregarded under most experimental conditions - if only to predict the solution pH - and must therefore be an integral part of the geochemical model.

  9. Aging parents' caregiving and rehabilitating a brain-injured son: an autoethnography of a 10-year journey.

    Science.gov (United States)

    Hassan, Syed Tajuddin Syed; Jamaludin, Husna

    2014-01-01

    This autoethnography withdraws from information accumulated through a 10-year period of daily-weekly-monthly descriptive observation-recording (triangulated- parents & house-helper) of caregiving and rehabilitating of our brain injured son (survivor/care-receiver). We present it as an interactive voice of verbal conversation, thoughts, insights, and interpretations. It is delivered as a series of articulation intra-pulsated with our interrogation of societal-cultural-religious perspectives, norms and biases, and aligns with the CAP (Creative Analytical Practices) method of Ellis. This autoethnography glows from the richness of information which encapsulates the challenges confronting us the aging parent caregivers, the gradual incremental mind mending achievement of our son, and the interactive verbalizations and thoughts, of the caregivers, care-receiver, and other persons. The overwhelming mental and physical pain and struggle of the survivor and the aging caregivers and their sense of celebratory-satisfaction with rehabilitation progress are highlighted. Interpretation and valuation of positive and negative responses of other persons provide a critical matrix to this autoethnography. We intend to inform other caregivers and relevant healthcare professionals through this autoethnography.

  10. Aging parents’ caregiving and rehabilitating a brain-injured son: an autoethnography of a 10-year journey

    Science.gov (United States)

    Hassan, Syed Tajuddin Syed; Jamaludin, Husna

    2014-01-01

    This autoethnography withdraws from information accumulated through a 10-year period of daily-weekly-monthly descriptive observation-recording (triangulated- parents & house-helper) of caregiving and rehabilitating of our brain injured son (survivor/care-receiver). We present it as an interactive voice of verbal conversation, thoughts, insights, and interpretations. It is delivered as a series of articulation intra-pulsated with our interrogation of societal-cultural-religious perspectives, norms and biases, and aligns with the CAP (Creative Analytical Practices) method of Ellis. This autoethnography glows from the richness of information which encapsulates the challenges confronting us the aging parent caregivers, the gradual incremental mind mending achievement of our son, and the interactive verbalizations and thoughts, of the caregivers, care-receiver, and other persons. The overwhelming mental and physical pain and struggle of the survivor and the aging caregivers and their sense of celebratory-satisfaction with rehabilitation progress are highlighted. Interpretation and valuation of positive and negative responses of other persons provide a critical matrix to this autoethnography. We intend to inform other caregivers and relevant healthcare professionals through this autoethnography. PMID:25763170

  11. It Is Necessary to Abrogate All the International Basic Standards of Seals%必需废除所有国际密封基础标准

    Institute of Scientific and Technical Information of China (English)

    徐长祥; 张晓忠; 陈佑军

    2016-01-01

    According to the definitions in the international standard JCGM 200,physical quanti-ties are the quantifiable properties of phenomenon,obj ect,or material,which could be classified into two - basic quantity and export quantity.Basic quantity cannot be the one expressed by u-sing other quantity,and the export quantity is the one defined by using the basic quantity in its system,and the basic quantity and export quantity in its system are correlated with through law and its equation.In unit on international system,the sealing tightness,the leakage resistance,is the exported quantity established by sealing or leakage,and is the product of time t and pressure p,the time which is consumed by the leaked unit volume fluid in pressure vessel under constant pressure or in the system through sealed joint.Absolutely,it is not the reciprocal of “leakage rate”fabricated in existing international standard.The difference of inner pipe flow routing,the external obj ect flow routing and leakage flow routing is only their flow (leakage)resistance and reactance.It is hardly to make difference and control flow routing before the leakage resistance and reactance unknown.The international sealing basic standard has been set up under the condi-tion of the leakage resistance (tightness)and qualified sealing unknown,and thence how to de-sign,install and acceptance inspection of sealing.So,the basic standard cannot be relied upon to provide efficient control of pressure or system leakage.It is the must to abrogate it in a quick ac-tion.%按照国际标准JCGM 200定义,物理量是现象、物体或物质的可量化属性,可以分为基本量和导出量两种;基本量是不可用其它量表达的量,导出量是可用其系统基本量定义的量;系统内的基本量和导出量可以通过定律及其方程进行相关联。在国际单位制中,密封紧密度即漏阻是由密封或泄漏定律确立的导出量,是恒压状态下压力容器或系统穿过密

  12. Riad al-Solh en son temps (Riyâd Al-Sulh fî zamâni-hi, Beyrouth, Dar An-Nahar, 2011

    Directory of Open Access Journals (Sweden)

    Ahmad Beydoun

    2011-10-01

    Full Text Available Riad al-Solh a été assassiné à l’âge de cinquante-sept ans. Au cours des dernières années de sa vie, il tint à rappeler son parcours et son expérience à ses jeunes collègues du Parlement, cherchant ainsi à aiguiser leur discernement. Son engagement précoce en politique (que l’on nommait jihad à cette époque, puis son départ, avaient occupé toute sa vie. Elles lui conféraient l’aura d’un vieux sage. Ces quarante années de carrière avaient conduit le jeune étudiant en droit d’un bureau d’Istan...

  13. Cognitive ability correlates positively with son birth and predicts cross-cultural variation of the offspring sex ratio

    Science.gov (United States)

    Dama, Madhukar Shivajirao

    2013-06-01

    Human populations show remarkable variation in the sex ratio at birth which is believed to be related to the parental condition. In the present study, the global variation of sex ratio at birth (SRB, proportion of male offspring born) was analyzed with respect to indirect measure of condition, the intelligence quotient (IQ). IQ correlates strongly with lifespan across nations, which makes it a good indicator of health of the large populations. Relation between three standard measures of average national IQ and SRB was studied using multiple linear regression models. Average national IQ was positively correlated with SRB ( r = 0.54 to 0.57, p maternal age, polygyny prevalence, wealth, son preference, latitude, low birth weight, and neonatal mortality in the regression models. These results suggest that the striking variation of offspring sex ratio across nations could be caused in part by the difference in general condition of populations.

  14. Clonage de l'IGF-I et de son récepteur chez le turbot (Psetta maxima)

    OpenAIRE

    ELIES G.; Duval, H.; GROIGNO L.; Wolff, J.; Boeuf, G.; BOUJARD D.

    1998-01-01

    Les IGF, leurs récepteurs et leurs protéines de liaison constituent une famille moléculaire qui joue un rôle essentiel dans la régulation de la croissance et du développement. Nous nous sommes intéressés à la caractérisation moléculaire de l'IGF-l et de son récepteur (IGF-1R) chez le turbot (Psetta maxima), un poisson plat téléostéen. Par RT-PCR, nous avons clone un ADNc codant pour les quatre domaines de l'IGF-l mature. La protéine présente 70 à 96 % d'identité avec les autres IGF-I de verté...

  15. Integrable String Models in Terms of Chiral Invariants of SU(n, SO(n, SP(n Groups

    Directory of Open Access Journals (Sweden)

    Victor D. Gershun

    2008-05-01

    Full Text Available We considered two types of string models: on the Riemmann space of string coordinates with null torsion and on the Riemman-Cartan space of string coordinates with constant torsion. We used the hydrodynamic approach of Dubrovin, Novikov to integrable systems and Dubrovin solutions of WDVV associativity equation to construct new integrable string equations of hydrodynamic type on the torsionless Riemmann space of chiral currents in first case. We used the invariant local chiral currents of principal chiral models for SU(n, SO(n, SP(n groups to construct new integrable string equations of hydrodynamic type on the Riemmann space of the chiral primitive invariant currents and on the chiral non-primitive Casimir operators as Hamiltonians in second case. We also used Pohlmeyer tensor nonlocal currents to construct new nonlocal string equation.

  16. Trajectories and Determinants of Elder Care in Rural China During an 8-Year Period: Why Having Sons Makes a Difference.

    Science.gov (United States)

    Guo, Man; Chi, Iris; Silverstein, Merril

    2016-07-01

    Using 8-year panel data for 1,355 older adults in rural Anhui province, China, this study examined the trajectories and determinants of elder care provided by adult children to their older parents. The results of two-level latent variable growth models showed that trajectories of elder care differed by the gender of children, with an increase in care from sons but a decrease in care from daughters over time. Children's life stages influenced their care provision but differed by gender. Functional impairment of parents and care provided by siblings in the family also affected the care provided by each child. The findings reflect the patrilineal nature of Chinese family systems and demonstrate the linkages between critical life events and caregiving behaviors of adult children. Findings of this study can inform the formulation of elder care policies that meet the needs of families with different structures and at different life stages.

  17. L’analyse du discours et ses entre-deux : notes sur son histoire au Brésil

    OpenAIRE

    Puccinelli Orlandi, Eni

    2014-01-01

    À Paul Henry pour l’excellence théorique avec laquelle, dès le début, il a exploré la force et les nuances de l’analyse du discours. Introduction Mettant hors du champ de la réflexion discursive la notion d’« intervalle », je propose une pratique matérialiste de l’analyse du discours par son inscription dans un espace d’« entre-deux », jusqu’au sein même de l’histoire des théories linguistiques. À la différence de celle d’intervalle, l’idée d’entre-deux renvoie à des espaces simultanément hab...

  18. El drama de ser mujer en Todas las historias son de amor de Adolfo Torres

    OpenAIRE

    Gutiérrez García, Rosa María.

    2010-01-01

    La ideología expresa y se reproduce en la sociedad a través del discurso; en esa dirección, el espíritu que guía este análisis es el concepto de ideología asociado al discurso y será utilizado en el sentido de noción general de creencias, ya que pretendemos encontrar en el discurso del drama Todas las historias son de amor, de Adolfo Torres, las marcas de ideología relacionadas con el género. Nuestro objetivo particular es examinar cuál es la idea que sobre la mujer se tiene y cómo aparece en...

  19. La segregación residencial urbana en estudios latinoamericanos y bogotanos. ¿Son necesarias nuevas miradas?

    Directory of Open Access Journals (Sweden)

    Esperanza Cifuentes Ardila

    2015-12-01

    Full Text Available En América Latina, las lecturas sobre la segregación residencial urbana concluyen que las ciudades de la región son ámbitos territoriales segregados por razones económicas: las inequidades se expresan en la organización urbana. Este artículo tiene como propósito mostrar que, incluso en regiones tan desiguales como la nuestra, la estructura simbólica incide en la configuración de la segregación residencial urbana, pues la valoración que los agentes sociales dan a determinados lugares y grupos humanos es decisiva para su localización en el espacio urbano.

  20. The Sun-as-a-star observations: GOLF & VIRGO on SoHO, and BiSON network

    CERN Document Server

    Garcia, R A; Jimenez, A; Ballot, J; Mathur, S; Salabert, D; Chaplin, W J; Elsworth, Y; Regulo, C; Turck-Chieze, S

    2013-01-01

    Sun-as-a-star observations are very important for the study of the conditions within the Sun and in particular for the deep interior where higher degree modes do not penetrate. They are also of significance in this era of dramatic advances in stellar asteroseismology as they are comparable to those measured in other stars by asteroseismic missions such as CoRoT, Kepler, and MOST. More than 17 years of continuous measurements of SoHO and more than 30 years of BiSON observations provide very long data sets of uninterrupted helioseismic observations. In this work, we discuss the present status of all these facilities that continue to provide state- of-the-art measurements and invaluable data to improve our knowledge of the deepest layers of the Sun and its structural changes during the activity cycle.

  1. ¿También los extranjeros son iguales ante la ley? = Foreigners: are they equal before the law?

    OpenAIRE

    Mora Alemañy, Rosario

    2013-01-01

    «Los españoles son iguales ante la ley» (art. 14 CE). La recentísima STC 17/2013 señala que «los extranjeros gozan en España del derecho fundamental derivado del artículo 18.4 CE en las mismas condiciones que los españoles»; pero, como señala el voto particular del Magistrado Pérez Tremps, al que se unen otros tres magistrados, la regulación avalada por el Tribunal Constitucional en esta sentencia «pone de manifiesto una notable limitación del contenido esencial del derec...

  2. Action audio-visual for the promotion of between mother attachment seropositivity for HIV and his son

    Directory of Open Access Journals (Sweden)

    Camila Nayane de Carvalho Lima

    2012-09-01

    Full Text Available The study aimed at evaluating the effects of the educational video use to promote the attachment between HIV positive mother and her son after six months of contact between them.This is an exploratory-descriptive study with a qualitative approach. Data was collected through semi-structured interviews. The sampling was intentional. The plan of analysis consisted of the following steps: the constitution of the corpus, definition of unit analysis, data categorization and analysis through categories. This study showed that, despite the difficulties and obstacles imposed by HIV / AIDS, by the treatment and the doubts present in daily life, HIV mothers develop strategies that enable them to live and better deal with the disease, without forgetting their role as a mother.

  3. Cognitive ability correlates positively with son birth and predicts cross-cultural variation of the offspring sex ratio.

    Science.gov (United States)

    Dama, Madhukar Shivajirao

    2013-06-01

    Human populations show remarkable variation in the sex ratio at birth which is believed to be related to the parental condition. In the present study, the global variation of sex ratio at birth (SRB, proportion of male offspring born) was analyzed with respect to indirect measure of condition, the intelligence quotient (IQ). IQ correlates strongly with lifespan across nations, which makes it a good indicator of health of the large populations. Relation between three standard measures of average national IQ and SRB was studied using multiple linear regression models. Average national IQ was positively correlated with SRB (r = 0.54 to 0.57, p wealth, son preference, latitude, low birth weight, and neonatal mortality in the regression models. These results suggest that the striking variation of offspring sex ratio across nations could be caused in part by the difference in general condition of populations.

  4. Simulated alteration tests on non-radioactive SON 68 nuclear glass in the presence of corrosion products and environmental materials

    International Nuclear Information System (INIS)

    Alteration tests with non-radioactive French SON 68 (R7T7-type) nuclear glass in the presence of simulated metal canister corrosion products (CP) or environmental materials (EM) were simulated using the LIXIVER2 computer code. The code incorporates hypotheses concerning glass alteration in aqueous media based on the first-order kinetic law for total silicon with variable silicon retention in the gel and silicon diffusion in the gel interstitial water, coupled with silicon adsorption and diffusion in the materials in contact with the glass. The canister CP are considered as a localized medium with a mass adsorption capacity Rad, while the EM are considered as a porous medium with a diffusion coefficient Dp and a distribution coefficient Kd. LIXIVER2 simulates these media in one-dimensional Cartesian geometry. The Kd values determined by simulating alteration tests logically increase with the aggressiveness of the materials with respect to the glass

  5. SON68 nuclear glass dissolution kinetics: Current state of knowledge and basis of the new GRAAL model

    Energy Technology Data Exchange (ETDEWEB)

    Frugier, P. [CEA Marcoule, DTCD/SECM/LCLT, BP 17171, 30207 Bagnols-sur-Ceze cedex (France)], E-mail: pierre.frugier@cea.fr; Gin, S.; Minet, Y.; Chave, T. [CEA Marcoule, DTCD/SECM/LCLT, BP 17171, 30207 Bagnols-sur-Ceze cedex (France); Bonin, B. [CEA Saclay, DEN/DIR/DS, 91191 Gif-sur-Yvette cedex (France); Godon, N.; Lartigue, J.-E.; Jollivet, P. [CEA Marcoule, DTCD/SECM/LCLT, BP 17171, 30207 Bagnols-sur-Ceze cedex (France); Ayral, A. [IEM/CNRS-ENSCM Universite Montpellier 2, CC 047, Place Eugene Bataillon, 34095 Montpellier cedex 5 (France); De Windt, L. [ENSMP, CG, 35 rue St Honore, 77305 Fontainebleau cedex (France); Santarini, G. [CEA Saclay HC/CAB, 91191 Gif-sur-Yvette cedex (France)

    2008-10-15

    This article summarizes the present state of knowledge concerning aqueous alteration of R7T7-type nuclear containment glasses, represented mainly by the inactive reference glass designated SON68. Based on this review, we propose to describe the glass alteration kinetics up to and including the final residual rate regime by means of a new mechanistic model known as GRAAL (glassreactivitywithallowanceforthealterationlayer). Phenomenological analysis findings are reviewed for the various glass alteration regimes: interdiffusion, initial rate, rate drop, residual rate and, under very particular circumstances, resumption of alteration. These alteration regimes are associated with predominant mechanisms. Published work interpreting and modeling these mechanisms was examined in detail. There is a broad consensus on the general mechanisms of the initial rate and even the interdiffusion regime, whereas the mechanisms controlling the rate drop remain a subject of dispute not only with regard to nuclear glasses but also for the dissolution of silicate minerals. The reaction affinity responsible for the rate drop is expressed differently by different authors and depending on the underlying theories. The disagreement concerns the nature of the phase (glass or gel) or the activated complex controlling the rate drop, which in turn determines the elements that must be taken into account in the overall affinity term. Progress in recent years, especially in identifying the mechanisms responsible for the residual rate, has shed new light on these issues, allowing us to propose new theoretical foundations for modeling the different kinetic regimes of SON68 nuclear glass dissolution. The GRAAL model considers that water diffusion in the passivating reaction zone (the gel formed under saturation conditions) is a rate-limiting step in the overall glass dissolution kinetics. Moreover, this passivation zone is a soluble phase whose stability is directly dependent on the nature of the

  6. Deletion of locus D15S113 in a mother and son without features of Angelman syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Michaelis, R.C.; Tarleton, J.C.; Donlon, T.A.; Simensen, R.J. [Greenwood Gneetic Center, SC (United States)] [and others

    1994-09-01

    Deletions of the proximal long arm of chromosome 15 result in Angelman syndrome when inherited from the mother and Prader-Willi syndrome when inherited from the father. The minimal critical deletion region for Angelman syndrome has been reported to include D15S74 (B1.5), D15S10 (TD3-21), and D15S113 (LS6-1). We report a mother and son who have deletions that include D15S113 but who do not have features of Angelman syndrome. D.H. is a 10-year-old white male referred for genetic evaluation due to mental retardation. He has mild to moderate mental retardation and minor dysmorphic features, including downslanting palpebral fissures, prominent nose, broad forehead, small chin, midface hypoplasia, and large ears. His mother (B.S.) has slightly downslanting palpebral fissures and a borderline intellectual deficit. Neither individual has the seizures, excessive laughter, hand clapping, ataxia or facial dysmorphism which are characteristic of Angelman syndrome. The linear order of probes mapping to 15q11-q13 is 15cen-D15S11-D15S13-D15S10-D15S113-GABRB3-D15S12-tel. The proximal border of the deletion in our patients lies between D15S10 and D15S113. The fact that these two individuals do not have Angelman syndrome, despite deletion of D15S113, suggests that the Angelman syndrome critical deletion region should be further refined to exclude the D15S113 locus. In addition, the findings of a more severe intellectual impairment in the son than in the mother suggests that the region immediately telomeric to the critical deletion region for Angelman syndrome may contain imprintable genes that influence intellectual function.

  7. Sweet Sorrow's Son.

    Science.gov (United States)

    Brothers, Deborah

    1997-01-01

    Presents an award-winning essay about a teacher's relationship with a troubled student placed in his alternative classroom. Shows how the two worked together on science, math, and "Romeo and Juliet." (TB)

  8. Sons & Lumieres / Ivar Jung

    Index Scriptorium Estoniae

    Jung, Ivar

    2004-01-01

    Näitus "Hääl ja valgus" Pariisi Pompidou keskuses 22. IX 2004-3. I 2005. Väljas on 99 kunstniku (Paul Klee, Frantishek Kupka, Vassili Kandinsky, Laszlo Moholy-Nagy, Raoul Hausmann, Bill Viola, Robert Rauschenberg, Joseph Beuys, Rodney Graham jne.) tööd ajavahemikust 1910-2004. Kuraatorid Sophie Duplaix ja Marcella Lista

  9. SON68 nuclear glass dissolution kinetics: Current state of knowledge and basis of the new GRAAL model

    Energy Technology Data Exchange (ETDEWEB)

    Frugier, P.; Gin, S.; Minet, Y.; Chave, T. [CEA Marcoule, DTCD SECM LCLT, 30 (France)

    2009-06-15

    Complete text of publication follows: Based on a review of the current state of knowledge concerning the aqueous alteration of SON68 nuclear glass GRAAL (Glass Reactivity with Allowance for the Alteration Layer) mechanistic model has been proposed [1]: An amorphous layer at the glass/solution interface gradually reorganized by hydrolysis and condensation mechanisms constitutes a barrier against the transport of water toward the glass and of solvated glass ions into solution [2]. The existence of this transport-inhibiting effect rapidly causes this layer to control glass alteration. The reaction affinity responsible for the glass alteration rate drop is expressed with respect to this passivating reactive interphase (PRI). Some glass constituent elements precipitate as crystallized secondary phases on the external surface and can sustain glass alteration. Correctly modeling the seat of recondensation (PRI or secondary crystallized phases) of elements is a key point for understanding their effect on glass alteration. Describing not only (1) solution chemistry but also ion transport (2) in solution by at a macroscopic scale and (3) by reactive interdiffusion in the PRI at a nanometer scale by means of a single model at each point in space and time is a complex task. Most existing models describe only one or two of these aspects. GRAAL describes a simple and still effective manner of coupling theses three phenomena using a calculation code coupling chemistry and transport HYTEC [3]. The model results are compared with experimental data for SON68 glass leached in initially pure water both in a closed system and in renewed media. The comparison shows the model very satisfactorily accounts for variations in the pH and the element concentrations in solution as a function of time, glass surface area in contact with solution, and solution renewal rate. Interdiffusion through the PRI cannot be disregarded under most experimental conditions - if only to predict the solution p

  10. De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome.

    Science.gov (United States)

    Kim, Jung-Hyun; Shinde, Deepali N; Reijnders, Margot R F; Hauser, Natalie S; Belmonte, Rebecca L; Wilson, Gregory R; Bosch, Daniëlle G M; Bubulya, Paula A; Shashi, Vandana; Petrovski, Slavé; Stone, Joshua K; Park, Eun Young; Veltman, Joris A; Sinnema, Margje; Stumpel, Connie T R M; Draaisma, Jos M; Nicolai, Joost; Yntema, Helger G; Lindstrom, Kristin; de Vries, Bert B A; Jewett, Tamison; Santoro, Stephanie L; Vogt, Julie; Bachman, Kristine K; Seeley, Andrea H; Krokosky, Alyson; Turner, Clesson; Rohena, Luis; Hempel, Maja; Kortüm, Fanny; Lessel, Davor; Neu, Axel; Strom, Tim M; Wieczorek, Dagmar; Bramswig, Nuria; Laccone, Franco A; Behunova, Jana; Rehder, Helga; Gordon, Christopher T; Rio, Marlène; Romana, Serge; Tang, Sha; El-Khechen, Dima; Cho, Megan T; McWalter, Kirsty; Douglas, Ganka; Baskin, Berivan; Begtrup, Amber; Funari, Tara; Schoch, Kelly; Stegmann, Alexander P A; Stevens, Servi J C; Zhang, Dong-Er; Traver, David; Yao, Xu; MacArthur, Daniel G; Brunner, Han G; Mancini, Grazia M; Myers, Richard M; Owen, Laurie B; Lim, Ssang-Taek; Stachura, David L; Vissers, Lisenka E L M; Ahn, Eun-Young Erin

    2016-09-01

    The overall understanding of the molecular etiologies of intellectual disability (ID) and developmental delay (DD) is increasing as next-generation sequencing technologies identify genetic variants in individuals with such disorders. However, detailed analyses conclusively confirming these variants, as well as the underlying molecular mechanisms explaining the diseases, are often lacking. Here, we report on an ID syndrome caused by de novo heterozygous loss-of-function (LoF) mutations in SON. The syndrome is characterized by ID and/or DD, malformations of the cerebral cortex, epilepsy, vision problems, musculoskeletal abnormalities, and congenital malformations. Knockdown of son in zebrafish resulted in severe malformation of the spine, brain, and eyes. Importantly, analyses of RNA from affected individuals revealed that genes critical for neuronal migration and cortex organization (TUBG1, FLNA, PNKP, WDR62, PSMD3, and HDAC6) and metabolism (PCK2, PFKL, IDH2, ACY1, and ADA) are significantly downregulated because of the accumulation of mis-spliced transcripts resulting from erroneous SON-mediated RNA splicing. Our data highlight SON as a master regulator governing neurodevelopment and demonstrate the importance of SON-mediated RNA splicing in human development. PMID:27545680

  11. A case study of conflict management in bonobos: how does a bonobo (Pan paniscus) mother manage conflicts between her sons and her female coalition partner?

    Science.gov (United States)

    Legrain, L; Stevens, J; Alegria Iscoa, J; Destrebecqz, A

    2011-01-01

    Female coalitions are an important part of the social organization of bonobos. The strength of the mother-son relationship is another essential part of this social structure. A bonobo mother is therefore facing a dilemma when a conflict arises between her sons and her female coalition partners. Will she take her coalition partner's side and favour the social organization of the group or support her son in order to defend her offspring? In order to address this issue, we performed an observational study of the captive group at Planckendael (Belgium) and used social grooming and proximity to assess the relationship between individuals. As a case study, we focused on the relationships between Hortense, one of the group's mothers, her 3 sons Redi, Vifijo and Zamba, and her coalition partner Hermien. Surprisingly, we observed that Hortense preferentially supported her female coalition partner. For Hortense's social status in the group, it may be more important to maintain the strong relationship with her higher-ranking female coalition partner than to support her sons. PMID:22286277

  12. Household opportunity costs of protecting and developing forest lands in Son La and Hoa Binh Provinces, Vietnam

    Directory of Open Access Journals (Sweden)

    Le Ngoc Lan

    2016-09-01

    Full Text Available Vietnam has pilot-tested a payment for forest environmental services (PFES program in an effort to restore and protect forest areas, some of which have been severely degraded by the excessive cutting of trees by small-scale farmers planting annual crops on steep, sloping lands. The pilot program implemented in southern Vietnam seems to be successful, yet the program in northern Vietnam has not produced the desired rates of planting and maintaining forest areas. The reasons for these mixed results include differences in socio-economic characteristics and also the production and marketing opportunities available to rural households in the project areas. To gain insight regarding program participation, we examine the household-level opportunity costs of planting and ­maintaining small plots of forest trees in northern Vietnam. We find that small-scale farmers in Hoa Binh Province, with limited financial resources, prefer the annual revenue stream provided by crops such as maize and cassava, rather than waiting for 7 years to obtain revenue from a forest planting. Farmers in Son La Province, with limited access to markets, prefer annual crops because they are not able to sell bamboo shoots and other forest products harvested from their small plots. In both provinces, the payments offered for planting and maintaining forest trees are smaller than the opportunity costs of planting and harvesting annual crops. Thus, most households likely would choose not to participate in the PFES program, at current payment rates, if given the opportunity to decline.

  13. Facies, dissolution seams and stable isotope compositions of the Rohtas Limestone (Vindhyan Supergroup) in the Son valley area, central India

    Indian Academy of Sciences (India)

    S Banerjee; S K Bhattacharya; S Sarkar

    2005-02-01

    The early Mesoproterozoic Rohtas Limestone in the Son valley area of central India represents an overall shallowing-upward carbonate succession. Detailed facies analysis of the limestone reveals outer- to inner-shelf deposition in an open marine setting. Wave-ripples, hummocky cross strat- ifications and edgewise conglomerates argue against a deep marine depositional model for the Rohtas Limestone proposed earlier. Stable isotope analysis of the limestone shows that 13C and 18O values are compatible with the early Mesoproterozoic open seawater composition. The ribbon limestone facies in the Rohtas Limestone is characterized by micritic beds, each decoupled in a lower band enriched and an upper band depleted in dissolution seams. Band-wise isotopic analysis reveals systematic short-term variations. Comparative enrichment of the heavier isotopes in the upper bands is attributed to early cementation from sea water and water derived from the lower band undergoing dissolution because of lowering of pH at depth. The short-term positive shifts in isotopic compositions in almost every upward gradational transition from a seamed band to a non-seamed band support the contention that dissolution seams here are of early diagenetic origin, although their formation was accentuated under overburden pressure.

  14. How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia.

    Science.gov (United States)

    Blaul, Birgit; Ruther, Joachim

    2011-11-01

    Sexual selection theory predicts that phenotypic traits used to choose a mate should reflect honestly the quality of the sender and thus, are often costly. Physiological costs arise if a signal depends on limited nutritional resources. Hence, the nutritional condition of an organism should determine both its quality as a potential mate and its ability to advertise this quality to the choosing sex. In insects, the quality of the offspring's nutrition is often determined by the ovipositing female. A causal connection, however, between the oviposition decisions of the mother and the mating chances of her offspring has never been shown. Here, we demonstrate that females of the parasitic wasp Nasonia vitripennis prefer those hosts for oviposition that have been experimentally enriched in linoleic acid (LA). We show by (13)C-labelling that LA from the host diet is a precursor of the male sex pheromone. Consequently, males from LA-rich hosts produce and release higher amounts of the pheromone and attract more virgin females than males from LA-poor hosts. Finally, males from LA-rich hosts possess three times as many spermatozoa as those from LA-poor hosts. Hence, females making the right oviposition decisions may increase both the fertility and the sexual attractiveness of their sons. PMID:21429922

  15. ¿SON EFECTIVOS LOS CONSEJOS DE ADMINISTRACIÓN? LA EFICACIA DEL CONSEJO Y LOS RESULTADOS DE LA EMPRESA

    Directory of Open Access Journals (Sweden)

    Barroso Castro, C.

    2010-01-01

    Full Text Available Numerosos trabajos han estudiado la influencia del consejo de administración en las decisiones y resultados de sus empresas. No obstante, la enorme popularidad alcanzada en el campo del gobierno corporativo por estos estudios, no viene acompañada por sus resultados, que han sido ambiguos y, a veces, conflictivos En esta investigación proponemos que la efectividad de los consejos depende de las experiencias y conocimientos de los consejeros que lo conforman, así como de la estructura de estos consejos. Entendemos que ambas dimensiones (composición y estructura no son “por si” suficientes para el logro de consejos plenamente efectivos, pero si se definen como elementos necesarios para ello. Desde nuestra perspectiva, constituyen el potencial que permitirá lograr una adecuada capacidad estratégica por parte del consejo. Nuestros resultados muestran la importancia de las variables que conforman la estructura y composición del consejo (tamaño del consejo, permanencia, experiencia de los consejeros a la hora de explicar los resultados empresariales.

  16. 2-D Crustal thermal structure along Thuadara–Sindad DSS profile across Narmada– Son lineament, central India

    Indian Academy of Sciences (India)

    S N Rai; S Thiagarajan

    2007-08-01

    Central India is traversed by a WSW–ENE trending Narmada–Son lineament (NSL) which is characterized by the presence of numerous hot springs, feeder dykes for Deccan Traps and seismicity all along its length. It is divided in two parts by the Barwani–Sukta Fault (BSF). To the west of this fault a graben exists, whereas to the east the basement is uplifted between Narmada North Fault (NNF) and Narmada South Fault (NSF). The present work deals with the 2-D thermal modeling to delineate the crustal thermal structure of the western part of NSL region along the Thuadara–Sindad Deep Seismic Sounding (DSS) profile which runs almost in the N–S direction across the NSL. Numerical results of the model reveal that the conductive surface heat flow value in the region under consideration varies between 45 and 47mW/m2. Out of which 23mW/m2 is the contribution from the mantle heat flow and the remaining from within the crust. The Curie depth is found to vary between 46 and 47 km and is in close agreement with the earlier reported Curie depth estimated from the analysis of MAGSAT data. The Moho temperature varies between 470 and 500°C. This study suggests that this western part of central Indian region is characterized by low mantle heat flow which in turn makes the lower crust brittle and amenable to the occurrence of deep focused earthquakes such as Satpura (1938) earthquake.

  17. Tectonomagnetic study in the seismoactive area of Narmada–Son lineament, central India: Preliminary results on repeat field observations

    Indian Academy of Sciences (India)

    S Y Waghmare; S D Pimprikar; P B Gawali; L Carlo; A G Patil

    2009-06-01

    Repeated measurements of the total geomagnetic field on the five profiles have revealed a picture of stress-induced tectonomagnetic effect in the form of secular variation of the total geomagnetic field in the tectonically and seismically active area of Jabalpur and adjoining areas of the Narmada-Son lineament (NSL),central India.For this experiment,a reference base station was established within the study area at Jabalpur.Using proton precession magnetometers with a sensitivity of 0.1 nT, simultaneous measurements of total geomagnetic field were made annually at the base and all field stations.Five cycles of repeated observations have been performed between 2003 and 2007.For data analysis,a difference method has been applied and the residuals have been calculated as secular variations of the total geomagnetic field with values ranging from ± 0.1nT to about > ± 14.6nT/yr over the different stations.The anomalies in secular variation of the total geomagnetic field may be related to anomalous accumulation of tectonic stresses and tensions on the deep fault zones and crustal blocks due to recent geodynamic processes and active geological inhomogeneities in the NSL.

  18. Indicadores regionales de desarrollo sustentable en Chile: ¿Hasta qué punto son útiles y necesarios?

    Directory of Open Access Journals (Sweden)

    Hernán Blanco

    2001-09-01

    Full Text Available Cada vez más necesitamos maneras de asegurar patrones de desarrollo que sean sustentables, es decir, que sean ambiental, social y económicamente apropiados para nosotros y para las generaciones venideras. Los indicadores de desarrollo sustentable son una herramienta promisoria que permitiría "aterrizar" el concepto de sustentabilidad, apoyando la manera en que se toman las decisiones. En Chile existen pocas experiencias sobre el tema. Este artículo presenta el trabajo realizado para desarrollar indicadores de desarrollo sustentable en cuatro regiones del país. El artículo se centra en las lecciones que han surgido de la experienciaWe are increasingly needing ways to secure patterns of development that be sustainable, that is, environmentally, socially and economically appropriate for us and for future generations. Sustainability indicators are a promising tool that would allow us to "land" the concept, supporting the way in which decisions are made. In Chile there are few experiences on the subject. This paper presents the work carried out to develop sustainability indicators in four regions. The paper focuses on the lessons that have been drawn from the experience

  19. Precios de los medicamentos: cómo se establecen y cuáles son sus sistemas de control

    Directory of Open Access Journals (Sweden)

    Joan Rovira Forns

    2015-01-01

    Full Text Available El precio es una de las principales barreras de acceso a los medicamentos. Por ello es importante conocer cómo se forman los precios y qué factores determinan su cuantía y también qué formas de intervención y regulación son las más adecuadas teniendo en cuenta sus efectos, tanto sobre el acceso, como sobre la innovación, la producción local y otros posibles objetivos de la política de medicamentos. El análisis económico ha desarrollado un conjunto de modelos de mercado que permiten explicar el comportamiento de los precios, aunque los mercados reales divergen sustancialmente de los modelos teóricos. La regulación de precios está justificada por los llamados “fallos de mercado”; la regulación de precios basada en el costo de producción, la modalidad de control de precios más tradicional, ha caído en desuso a favor de los sistemas de precios de referencia internacionales y por la fijación del precio basada en el valor.

  20. Bill project aiming at prohibiting the exploration and exploitation of unconventional hydrocarbons, and at abrogating exclusive search permits for liquid or gaseous hydrocarbon mines, and aiming at ensuring transparency in the issue of search permits and concessions

    International Nuclear Information System (INIS)

    As offshore drillings and the search for unconventional gas has faced a strong opposition by part of the French population, this bill project (presented mainly by the Socialist group) aims at prohibiting these practices in France, and notably at abrogating some exclusive search permits which have been recently awarded. The authors outline the main motivations of this bill project: these exploitation and mining techniques are very expensive; they have several negative impacts with respect to environment protection commitments like the Grenelle de l'Environnement and the Grenelle de la Mer; these techniques have also an impact on water resources, and generate pollution which impacts water quality as well as ecosystems and biodiversity; some chemical products used by these techniques are carcinogenic (as it already appeared in the USA and in Canada); and finally, the exploitation of unconventional hydrocarbons has a bad carbon assessment. This presentation if followed by the bill project text

  1. 心理干预提高独生子女士兵适应能力的研究%A Study on Psychological Intervention to Improve the Adaptability of the Only Son Recruits

    Institute of Scientific and Technical Information of China (English)

    李权超; 蓝新友; 何英强; 蒋忠军; 谭终意; 李兴国

    2002-01-01

    Objective: To study the effects of psychological intervention on the adaptability of the only son recruits. Methods: Mental status of the only son recruits and non-only son recruits were assessed using Symptom Checklist-90, Social Support Questionnaire and Simplified Coping Style Questionnaire before and after psychological intervention. Results: The only son recruits scored significantly higher on depression, anxiety, and interpersonal sensitivity prior to psychological intervention, when compared to the non-only son recruits (P<0.05 or 0.01). The scores of negative emotion decreased and the scores of positive coping style increased significantly in the only son recruits after psychological intervention (P<0.05 or0.01).Conclusion: Psychological intervention could improve the psychological status and adaptability of the only son recruits.

  2. Abrogation of heat-shock protein (HSP)70 expression induced cell growth inhibition and apoptosis in human androgen-independent prostate cancer cell line PC-3m

    Institute of Scientific and Technical Information of China (English)

    Zhi-GangZhao; Qing-ZhengMa; Chun-XiaoXu

    2004-01-01

    Aim: To investigate the effect of abrogating heat shock protein (HSP) 70 expression by antisense HSP70 oligonucleotides treatment on human androgen-independent prostate cancer cell line PC-3m growth. Methods: PC3m cells were treated with 0-16μmol/L antisense HSP70 oligomers for 0-100 hr. Cell growth inhibition was analyzed using a trypan blue dye exclusion test. Apoptotic cells were detected and confirmed by flow cytometric analysis and DNA fragmentation analysis. The protein expression of HSP70 and bcl-2 affected by antisense HSP70 oligomers were determined using Western blot. Results: Antisense HSP70 oligomer induced apoptosis and then inhibited proliferation of PC-3m cells in a dose- and time-dependent manner. Ladder-like patterns of DNA fragments were observed in PC-3m cells treated with 10μmol/L antisense HSP70 oligomer for 48 hr or 8μtmol/L for 72 hr on agarose gel electrophoresis. Antisense HSP70 oligomer pretreatment enhanced the subsequent induction of apoptosis by heat shock in PC-3m cells. In addition, undetectable HSP70 expression was observed at a concentration of 10μtmol/L antisense HSP70 oligomer treatment for 48 hr or 8μtmol/L for 72 hr in Western blot, which was paralleled by decreased expression levels of anti-apoptotic protein bcl-2. Conclusion: HSP70 antisense oligomer treatment abro-gates the expression of HSP70, which may disrupt HSP70-bcl-2-interactions and further down-regulate bcl-2 expression,in turn inducing apoptosis and inhibiting cell growth in PC-3m cells. (Asian JAndro12004 Dec;6:319-324)

  3. Y a-t-il un rapport entre les étymologies du Cratyle et les figures de son et anagrammes d’Héraclite ?

    OpenAIRE

    Mouraviev, Serge

    2014-01-01

    Platon dépeint Cratyle comme un disciple d’Héraclite en se fondant principalement sur son adhésion à la soi-disant théorie du flux universel de ce dernier. Nulle part dans le Cratyle, ni Socrate ni Cratyle ne lui attribuent une croyance dans une correction naturelle des noms. Mais c’est un fait bien établi qu’Héraclite utilisait largement dans son livre, entre autres figures de rhétorique, des structures phoniques extrêmement élaborées, et proposait nombre de jeux de mots « étymologiques » qu...

  4. Ürünlerde Son Kullanma Tarihinin Tüketicilerce Algılanmasına Yönelik Bir Araştırma

    OpenAIRE

    Açıkgözoğlu, Semih

    2006-01-01

    Bu çalışma ürünlerde son kullanma tarihinin tüketicilerce algılanmasına yönelik bir araştırmadır. Anket yoluyla elde edilen bilgilerin istatiksel anlamda ilişkileri incelenmiştir. Sonuç olarak tüketicilerin son kullanma tarihine dikkat ettikleri ve tüketicilik bilincinin ülkemizde de oluşmaya başladığı anlaşılmıştır.

  5. Clonage de l'IGF-I et de son récepteur chez le turbot (Psetta maxima

    Directory of Open Access Journals (Sweden)

    ELIES G.

    1998-07-01

    Full Text Available Les IGF, leurs récepteurs et leurs protéines de liaison constituent une famille moléculaire qui joue un rôle essentiel dans la régulation de la croissance et du développement. Nous nous sommes intéressés à la caractérisation moléculaire de l'IGF-l et de son récepteur (IGF-1R chez le turbot (Psetta maxima, un poisson plat téléostéen. Par RT-PCR, nous avons clone un ADNc codant pour les quatre domaines de l'IGF-l mature. La protéine présente 70 à 96 % d'identité avec les autres IGF-I de vertébrés. Le clonage de la séquence codante entière du récepteur a nécessité la construction d'une banque d'ADNc d'embryons de turbots. Le récepteur est organisé en domaines dont la taille et les caractéristiques sont semblables à celles des autres récepteurs aux IGF de type 1 décrits chez les mammifères et le poulet. La région catalytique est particulièrement conservée. Dans certains domaines, notamment dans la région C-terminale du précurseur, quelques différences qui pourraient avoir une importance fonctionnelle sont cependant observées. Enfin, par RT-PCR, nous avons mis en évidence une régulation ontogénique du statut de polyadénylation des ARNm IGF-1R.

  6. Comment Hobbes tente de rendre son matérialisme acceptable dans les appendices du Léviathan

    Directory of Open Access Journals (Sweden)

    Anne Staquet

    2011-11-01

    Full Text Available Le Léviathan de Hobbes [1651] a subi de nombreuses attaques, au point qu’il est jugé responsable de la grande peste de 1665 et de l’incendie de Londres l’année suivante et que le parlement ouvre une procédure contre l’ouvrage. Aussi, lorsqu’en 1666, Thomas Hobbes veut publier la traduction latine de ce livre, il y adjoint trois appendices. La version latine de l’œuvre est généralement jugée plus acceptable que le texte originaire anglais. En étudiant la manière dont Hobbes traite de son matérialisme dans ces appendices, je tente de montrer que les addenda latins ne constituent en aucune manière un retour en arrière du texte, mais que le philosophe enrobe simplement davantage des propos que, par ailleurs, il rend plus radicaux.Hobbes’s Leviathan [1651] has been critiqued so much that it was held responsible for the Great Plague of 1665 and the Fire of London during the following year, resulting in the Parliament instituting proceedings against the book. Therefore, when in 1666 Thomas Hobbes wanted to publish a Latin translation of this book, he added three appendices. Generally, the Latin version of the work is considered more acceptable than the English original text. By studying how Hobbes deals with his materialism in these appendices, I try to show that the Latin additions are in no way a reversal of the text, but that the philosopher simply veiled more propositions, while at the same time making them more radical.

  7. «¿Quién soy yo? ¿Quiénes son ellos/as?». Personajes en busca de identidad

    Directory of Open Access Journals (Sweden)

    Caretti, Laura

    2006-12-01

    Full Text Available Who am I? Who are they? These are the questions haunting the characters, created by writers such as Ibsen, Pirandello, Beckett and others, whose emblematic search for identity is explored in the article. The complex interconnections between subjectivity and alterity are focused within the coordinates of space (society and time (memory in their outward and inward movement. The characters are seen on stage relating also to the otherness of actors and spectators. Particular relief is given to the difference between the female and male search for identity in the light of contemporary historical changes.¿Quién soy yo? ¿Quiénes son ellos/as? Estas son las cuestiones que obsesionan a los personajes creados por escritores como Ibsen, Pirandello, Beckett y otros, cuya emblemática búsqueda de identidad se explora a lo largo de este artículo. Las complejas interconexiones entre subjetividad y alteridad son analizadas con las coordenadas del espacio (sociedad y el tiempo (memoria en su movimiento interno y externo. Los personajes son vistos en el escenario desde la alteridad de actores y espectadores. Un particular relieve se otorga a la diferencia entre la búsqueda de la identidad femenina y masculina a la luz de los cambios históricos contemporáneos.

  8. Bilateral Brown's syndrome in a mother and her son: case report Síndrome de Brown bilateral em mãe e filho: relato de caso

    Directory of Open Access Journals (Sweden)

    Rosália Maria Simões Antunes-Foschini

    2008-08-01

    Full Text Available This case report describes clinical data from mother and son with bilateral Brown's syndrome and highlights possible genetically determined predispositions.Este relato de caso descreve achados clínicos de mãe e filho com síndrome de Brown bilateral e discute a possibilidade de predisposição genética.

  9. Polyandrous females provide sons with more competitive sperm: Support for the sexy-sperm hypothesis in the rattlebox moth (Utetheisa ornatrix).

    Science.gov (United States)

    Egan, Andrea L; Hook, Kristin A; Reeve, H Kern; Iyengar, Vikram K

    2016-01-01

    Given the costs of multiple mating, why has female polyandry evolved? Utetheisa ornatrix moths are well suited for studying multiple mating in females because females are highly polyandrous over their life span, with each male mate transferring a substantial spermatophore with both genetic and nongenetic material. The accumulation of resources might explain the prevalence of polyandry in this species, but another, not mutually exclusive, possibility is that females mate multiply to increase the probability that their sons will inherit more-competitive sperm. This latter "sexy-sperm" hypothesis posits that female multiple mating and male sperm competitiveness coevolve via a Fisherian runaway process. We tested the sexy-sperm hypothesis by using competitive double matings to compare the sperm competition success of sons of polyandrous versus monandrous females. In accordance with sexy-sperm theory, we found that in 511 offspring across 17 families, the male whose polyandrous mother mated once with each of three different males sired significantly more of all total offspring (81%) than did the male whose monandrous mother was mated thrice to a single male. Interestingly, sons of polyandrous mothers had a significantly biased sex ratio of their brood toward sons, also in support of the hypothesis. PMID:26626578

  10. On the Relationship between Father and Son in Seize the Day%《只争朝夕》中的父子关系分析

    Institute of Scientific and Technical Information of China (English)

    吴丽聪

    2014-01-01

    Saul Bellow’s novel Seize the Day represents an extraordinary contribution to the relationship between father and son as a theme in fiction. This paper tries to analyze the relationship between the hero and his father in order to help the reader have a better understanding of the novel.

  11. 75 FR 5359 - In the Matter of L. Luria & Son, Inc., Lew Corp. (n/k/a Questus Global Limited), Library Bureau...

    Science.gov (United States)

    2010-02-02

    ... COMMISSION In the Matter of L. Luria & Son, Inc., Lew Corp. (n/k/a Questus Global Limited), Library Bureau...., Lindatech, Inc., Littlefield, Adams & Company, and Liuski International, Inc.; Order of Suspension of... Lew Corp. (n/k/a Questus Global Limited) because it has not filed any periodic reports since...

  12. "We Txt 2 Sty Cnnectd": An African American Mother and Son Communicate: Digital Literacies, Meaning-Making, and Activity Theory Systems

    Science.gov (United States)

    Lewis, Tisha Y.

    2013-01-01

    This research demonstrated how an African American mother and son communicated via texting and instant messaging at home. Data from a 2007 larger ethnographic case study of a family's digital literacy practices were collected and analyzed. Situated within the framework of New Literacy Studies and multimodality, this research explored: (a) how and…

  13. Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number

    DEFF Research Database (Denmark)

    Mau Kai, C; Juul, A; McElreavey, K;

    2008-01-01

    number, supplemented with haplogroup typing in deleted patients, were performed, in combination with clinical assessments in 264 fathers and their sons conceived by assisted reproduction techniques (ART), and in 168 fertile men with normal sperm concentration. RESULTS: In the ART fathers group, a...

  14. Legacies and Memorializations in the Intergenerational Transmission of Psychic Life: Psychoanalytic Notes on Some of the Ways in Which Sons Assume Their Father's Mantle.

    Science.gov (United States)

    Barratt, Barnaby B

    2016-04-01

    The intergenerational transmission of psychic life has been difficult to explore psychoanalytically given that a treatment of both parent and child is rarely, if ever, feasible. Here the issue is explored in terms of father-son relationships. Three legendary fathers (Abraham, Laius, Shiva) are discussed as illustrating the filicidal legacy they imposed psychically and corporeally on their sons. Three contemporary case vignettes are then presented, indicating ways in which sons ambivalently memorialize their fathers. This material provides a model as to some of the ways in which sons assume the mantle of the father's conscious and unconscious dynamics in the course of their personal history. Paternal legacies generate "memorializations" that express profound and poignant conflicts animating the son's psychic life. In the context of this investigation, the significance of the distinction between actual fathers or father figures (who are mortal, who possess some sort of gendered qualities, and who may be present or absent, emotionally and physically) and the "symbolic father" (who is the locus of the phallus that organizes the possibility of representational discourse) is discussed. It is suggested that boys and men typically develop in terms of confusions around this distinction. The oedipal conundrum and challenge of the boy's passage into manhood is then formulated as follows: Masculinity involves both the integration of patricidal desire (in response to the paternal legacy) and the mourning of actual fathers or father figures. It also involves the acceptance of the human condition, which is both that of mortality and of our "castratedness" in relation to the "symbolic father" as the locus of the phallus (the only one who knows whereof "He" speaks and acts, and who can neither be mourned nor surpassed). PMID:27042981

  15. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

    Directory of Open Access Journals (Sweden)

    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  16. La structure iconographique d’un art rupestre est-elle une clef pour son interprétation?

    Directory of Open Access Journals (Sweden)

    Georges SAUVET

    2009-12-01

    Full Text Available RÉSUMÉ: L’hypothèse émise par R. Layton selon laquelle la structure des arts rupestres diffère profondément, en termes de fréquence des motifs et de leur distribution entre les sites, en fonction de la religion et de l’organisation sociale des groupes humains est réexaminée dans ce travail collectif, à l’aide d’une documentation renouvelée et augmentée provenant d’Afrique et d’Australie, mais aussi d’une analyse approfondie de l’art pariétal paléolithique d’Europe occidentale. Il ressort de cette étude que l’hétérogénéité des sites (distribution géographique des motifs et la diversité de l’iconographie (fréquence des motifs sont des critères importants indubitablement liés à la structure sociale, aux croyances et à l’économie des sociétés, mais qu’ils ne permettent pas de trancher en faveur d’une organisation totémique ou de pratiques chamaniques.RESUMEN: La hipótesis de R. Layton según la cual la estructura de las artes rupestres difiere mucho en términos de frecuencia de los motivos y de su distribución entre los sitios, en función de la religión y de la organización social de los grupos humanos es examinada de nuevo en este trabajo colectivo, a la luz de una documentación nueva y aumentada procedente de África y Australia y de un análisis pormenorizado del arte parietal paleolítico de Europa occidental. Resulta de este estudio que la heterogeneidad de los sitios (distribución geográfica de los motivos y la diversidad de la iconografía (frecuencia de los motivos son criterios efectivamente ligados a la estructura social, a las creencias y a la economía de las sociedades, pero no permiten decidir a favor de una organización totémica o de prácticas chamánicas.

  17. ¿Son los chilenos igualmente solidarios?la influencia de los recursos personales en las donaciones de dinero

    Directory of Open Access Journals (Sweden)

    Juan Carlos Castillo

    2012-06-01

    Full Text Available En el discurso público comúnmente se asume que Chile es un país solidario, un supuesto que se confunde con la idea de una cierta homogeneidad en lo que respecta a valores solidarios y conductas de ayuda en el país. El presente trabajo apunta a cuestionar esta idea de homogeneidad respecto de solidaridad, proponiendo que las conductas solidarias se relacionan con los recursos que las personas poseen, los que a su vez se asocian al lugar que las personas ocupan en la estructura de estratificación social. Tomando los datos de la Encuesta de Solidaridad realizada en 2009 por el Centro de Medición MIDE UC de la Pontificia Universidad Católica de Chile, el trabajo se centra en un tipo de conducta de ayuda particular: las donaciones en dinero. El análisis se focaliza en la influencia de recursos personales como ingreso, educación y pertenencia a redes sobre este tipo de donaciones. Los resultados indican que los individuos con mayores recursos son más proclives a las donaciones, donde el nivel educacional alcanzado juega un papel preponderante.In the public discourse it is commonly assumed that Chile is a solidary country, an assumption that is mixed with the idea of homogeneity in the country as far as helping behavior and solidarity values is concerned. The present paper is aimed at challenging this homogeneity assumption by proposing that helping behavior is associated to personal resources, which at the same time are linked to the position in the social stratification structure. Using data from the Solidarity Survey implemented by the assessment center MIDE UC of the Pontificia Universidad Católica de Chile in 2009, the paper focuses on a specific type of helping behavior: money donations. The analysis centers on the influence of personal resources such as income, education and networks on this kind of donations. Results indicate that individuals with greater resources are more given to donate, whereby the educational level plays a key

  18. Influence of gamma irradiation effects on the residual alteration rate of the French SON68 nuclear glass

    Energy Technology Data Exchange (ETDEWEB)

    Rolland, S. [CEA/DEN/DTCD/SECM, BP 17171, 30207 Bagnols sur Cèze cedex (France); Tribet, M., E-mail: magaly.tribet@cea.fr [CEA/DEN/DTCD/SECM, BP 17171, 30207 Bagnols sur Cèze cedex (France); Jollivet, P.; Jégou, C.; Broudic, V.; Marques, C. [CEA/DEN/DTCD/SECM, BP 17171, 30207 Bagnols sur Cèze cedex (France); Ooms, H. [Instrumentation Department SCK-CEN, Belgian Nuclear Research Centre, Boeretang 200, B-2400 Mol (Belgium); Toulhoat, P. [Université de Lyon 1, CNRS/ISA, UFR de Chimie Biochimie, 69622 Villeurbanne cedex (France); INERIS, Parc Technologique Alata, BP 2, 60550 Verneuil en Halatte (France)

    2013-02-15

    The residual rate regime of SON68 nuclear glass has been investigated here by static experiments under external irradiation. The experiments were carried out in a gamma irradiator with {sup 60}Co sources. Four dose rates were studied: two high dose rates (5 and 10 kGy h{sup −1}) to exacerbate electronic radiation effects, and two lower dose rates (0.8 and 0.05 kGy h{sup −1}). The objective of this work is not to assess potential LET effects but to assess more widely electronic effects on the residual rate regime which controls the long term stability of the glass under geological disposal. Fresh glasses were leached in argon atmosphere at 90 °C and at a high surface-area-to-volume ratio (SA/V = 10 000 m{sup −1}). Under these conditions the system quickly reaches the residual alteration rate regime. The alteration rate was monitored by solution analyses: the release of glass alteration tracer elements—in particular boron, sodium and lithium—was measured by ICP-AES. The hydrogen peroxide produced by water radiolysis was quantified by chemiluminescence. Radiation effects on the glass and its gel network were characterized by scanning electron microscopy (SEM) and Transmission Electron Microscopy (TEM). Higher H{sub 2}O{sub 2} concentrations were measured on irradiated samples in the presence of glass, suggesting an irradiation effect on the glass and its alteration layer. However, the data obtained on glass alteration show that potential defects or changes induced by gamma irradiation do not modify the kinetics of alteration up to a gamma dose rate of 10 kGy h{sup −1}: the residual rates measured for the different dose rates studied are similar and comparable to experiments performed without irradiation. Moreover, these observations are consistent with SEM and TEM characterizations which show that the alteration layer formed under gamma irradiation is similar to the alteration layer formed without irradiation. This study demonstrates that species produced

  19. ¿Son válidas las curvas y tablas de crecimiento españolas actuales?

    Directory of Open Access Journals (Sweden)

    T. Durá Travé

    2012-02-01

    Full Text Available Objetivo: Modificar los resultados del Estudio longitudinal del crecimiento en Navarra (NA 09 mediante la exclusión en la muestra poblacional de los casos de obesidad; así como realizar un análisis comparativo con las curvas de crecimiento españolas e internacionales más cualificadas. Material y métodos: De los 930 participantes del NA-09 se han excluido todos los casos de obesidad según los estándares de Cole et al., siendo la muestra definitiva de 782 participantes (371 varones y 411 mujeres. Los resultados obtenidos se comparan con los estudios españoles de Serra-Majem et al (estudio enKid, Carrascosa et al (ESP 08 y NA 09, que no excluyen los casos de obesidad; así como, con las tablas del Center for Disease Control and Prevention (CDC, 2000 y de la OMS (WHO, 2007 que aplican criterios de depuración de valores antropométricos poco saludables (obesidad y malnutrición. Resultados: Se exponen los valores medios modificados de la talla, peso e IMC con su distribución percentilada, en ambos sexos. Al compararlos con los estudios españoles se observa que los valores evolutivos de los percentiles 3 y 50 correspondientes a la talla, peso e IMC son prácticamente similares; sin embargo, los valores evolutivos del percentil 97 correspondientes al peso e IMC se van distanciando progresivamente. Al compararlos con los estándares internaciones los valores evolutivos de los percentiles 3, 50 y 97 correspondientes al IMC se intercalaban entre ambas referencias. Conclusiones: Para que las curvas y tablas de crecimiento puedan servir como patrones de referencia convendría también excluir en su elaboración a todos los pacientes con obesidad; ya que, de otra manera, podrían llegar a considerarse como estudios meramente descriptivos de una población con una reconocida tendencia al exceso de peso corporal y, por tanto, su aplicabilidad clínica quedaría en entredicho.

  20. Biological effect of Acidithiobacillus thiooxidans on some potentially toxic elements during alteration of SON 68 nuclear glass

    Science.gov (United States)

    Bachelet, M.; Crovisier, J. L.; Stille, P.; Vuilleumier, S.; Geoffroy, V.

    2009-04-01

    Although underground nuclear waste repositories are not expected to be favourable places for microbial activity, one should not exclude localized action of extremophilic bacteria on some materials involved in the storage concept. Among endogenous or accidentally introduced acidophiles, some are susceptible to lead to a locally drastic decreased in pH, with potential consequences on materials corrosion. Experiments were performed with Acidithiobacillus thiooxidans on 100-125 m french reference nuclear glass SON68 grains in a mineral medium under static conditions during 60 days at 25degC. Growth medium was periodically renewed and analyzed by ICP-AES and ICP-MS spectrometry for both major, trace and ultra-trace elements. Biofilm formation was evidenced by confocal laser microscopy, staining DNA with ethidium bromide and exopolysaccharides with calcofluor white. Biofilm thickness around material grains exceeded 20 m under the chosen experimental conditions. It can be noticed that while numerous studies on biofilm formation upon interaction between Acidithiobacillus ferrooxidans and materials are found in the literature, evidence for biofilm formation is still scarce for the case of the acidophilic bacterium A. thiooxidans. Presence of biofilm is a key parameter for material alteration at the solid/solution interface in biotic systems. Indeed, various constitutive elements of materials trapped in the polyanionic polymer of biofilm may also influence the alteration process. In particular, biofilm may reduce the alteration rate of materials by forming a protective barrier at their surface (Aouad et al., 2008). In this study, glass alteration rates, determined using strontium as tracer, showed that the progressive formation of a biofilm on the surface of glass has a protective effect against its alteration. Uranium and rare earth elements (REE) are efficiently trapped in the biogenic compartment of the system (exopolysaccharides + bacterial cells). Besides, the ratio

  1. Alternative Constructions of Treason in the Angevin Political World: Traïson in the History of William Marshal

    Directory of Open Access Journals (Sweden)

    Stephen D. WHITE

    2007-05-01

    Full Text Available After some nobles and other fighting men surrendered Rochester castle to King John in 1215, John wanted to hang the nobles but refrained from doing so on the advice of one of his military captains. Would hanging the nobles for making war on the king have been lawful? This question about the law of treason has provoked inconclusive debate among historians who have sought to determine whether, in this period, making war against the English king was legally classified as lèse-majesté (crimen laesae majestatis, proditio or infidelitas. This article, however, asks whether the nobles whom John wanted to hang were guilty of traïson, as this vernacular term was used in the History of William Marshal (c. 1230. On this basis, the paper concludes that in all probability, the nobles who held Rochester against the king would not have been condemned as traitors, at least by their aristocratic peers.Cuando en 1215 ciertos nobles y otros combatientes se rindieron y entregaron el castillo de Rochester al rey Juan éste quiso colgarles, pero el consejo de uno de sus nobles le hizo absternerse. ¿Habría sido legítimo condenar a la horca a los que habían guerreado contra el rey? Cuestiones relativas al derecho de traición al intentar determinar si la guerra contra el rey de Inglaterra fue considerada en la época un crimen laesae majestatis, proditio, o infidelitas, según la definición que dan a estos términos las fuentes latinas, han suscitado debates interminables entre los historiadores. Este artículo, por el contrario, se pregunta si los nobles que el rey Juan deseaba colgar eran o no culpables de traición, en el sentido vernáculo del término que es usado en L’histoire de Guillaume le Maréchal (hacia 1230. Sobre esta base, la conclusión del artículo es que los nobles que ocuparon el castillo de Rochester, casi con total seguridad, no habrían sido condenados como traidores, al menos por sus pares.

  2. La riqueza y la pobreza de las naciones. ¿Por qué algunas son tan ricas y otras tan pobres?

    Directory of Open Access Journals (Sweden)

    Abel Ignacio López

    2010-08-01

    Full Text Available Landes, David. La riqueza y la pobreza de las naciones. ¿Por qué algunas son tan ricas y otras son tan pobres?, Barcelona, Editorial Crítica, 1999, 604 páginas. ¿Porqué hay naciones pobres y naciones ricas y cuál es la contribución de la historia en la comprensión de esta cuestión? El autor entiende por cultura el espíritu de empresa, el conjunto de valores que guían la conducta de una población, el dominio de la ciencia, la tecnología y el espíritu racional.

  3. Yo no soy marinero, soy capitán:Usos sociopolíticos contemporáneos del fandango y el son jarocho

    Directory of Open Access Journals (Sweden)

    Rafael Figueroa­ Hernández

    2015-01-01

    Siguiendo las reglas musicales y líricas tradicionales del son jarocho, un creciente grupo de personas han estado usando el fandango como una manera de participar en protestas sociales de varias maneras: a creando o manteniendo identidad entre grupos subalternos, b diseminando ideas políticas y sociales a través de letras basadas en formas tradicionales y c mediante la participación directa en manifestaciones y marchas entre otras.

  4. 现代文明中的爱情悲剧%The Traglc Love in Modern Civilization·On lawrence's Sons and Lovers

    Institute of Scientific and Technical Information of China (English)

    曾文雄

    2001-01-01

    Lawrence's Sons and Lover reflects the people in modern civilization are killed off their capacity and emotions to respond to the natural beauty and the loveliness in the human being. There are conflicts in pursuing :instinct, rationality and spirituality.Through the discussion on the hero's tragiclove stories, we can find only if hese conflicts can be solved,perfect humanity will be gained·

  5. A Buffett turns to farming in Africa: Warren's son Howard has quietly become a player in the fight against global hunger

    OpenAIRE

    Kilman, S.; Thurow, R.

    2009-01-01

    Metadata only record Warren Buffet's fourth son, Howard Buffet is an unassuming Illinois soybean and corn farmer. However, he plays a behind the scenes role in the global war against hunger. With a small portion of his father's fortune he spends much of the year traveling through Africa. Mr. Buffett is looking for ways to help African farmers increase their harvests without increasing their costs, thus his interest in developing plants that resist disease and drought.

  6. A new family of N dimensional superintegrable double singular oscillators and quadratic algebra Q(3) ⨁ so(n) ⨁ so(N-n)

    International Nuclear Information System (INIS)

    We introduce a new family of N dimensional quantum superintegrable models consisting of double singular oscillators of type (n, N-n). The special cases (2,2) and (4,4) have previously been identified as the duals of 3- and 5-dimensional deformed Kepler–Coulomb systems with u(1) and su(2) monopoles, respectively. The models are multiseparable and their wave functions are obtained in (n, N-n) double-hyperspherical coordinates. We obtain the integrals of motion and construct the finitely generated polynomial algebra that is the direct sum of a quadratic algebra Q(3) involving three generators, so(n), so(N-n) (i.e. Q(3) ⨁ so(n) ⨁ so(N-n)). The structure constants of the quadratic algebra itself involve the Casimir operators of the two Lie algebras so(n) and so(N-n). Moreover, we obtain the finite dimensional unitary representations (unirreps) of the quadratic algebra and present an algebraic derivation of the degenerate energy spectrum of the superintegrable model. (paper)

  7. Genetic data and de novo mutation rates in father-son pairs of 23 Y-STR loci in Southern Brazil population.

    Science.gov (United States)

    Da Fré, Nicole Nascimento; Rodenbusch, Rodrigo; Gastaldo, André Zoratto; Hanson, Erin; Ballantyne, Jack; Alho, Clarice Sampaio

    2015-11-01

    We evaluated haplotype and allele frequencies, as well as statistical forensic parameters, for 23 Y-chromosome short tandem repeats (STRs) loci of the PowerPlex®Y23 system (DYS19, DYS385a/b, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, Y-GATA-H4, DYS481, DYS533, DYS549, DYS570, DYS576, DYS643) in a sample of 150 apparently healthy males, resident in South Brazil. A total of 150 different haplotypes were identified. The highest gene diversity (GD) was observed for the single locus marker DYS570 (GD = 0.7888) and for a two-locus system DYS385 (GD = 0.9009). We also examined 150 father-son pairs by the same system, and a total of 13 mutations were identified in the 3450 father-son allelic transfers, with an overall mutation rate across the 23 loci of 3.768 × 10(-3) (95% CI: 3.542 × 10(-3) to 3.944 × 10(-3)). In all cases there was only one locus mutated with gain/loss of repeats in the son (5 one-repeat gains, and 7 one-repeat and 1 two-repeat losses); we observed no instances of mutations involving a non-integral number of repeats.

  8. De Masaccio à Stalker: pour une esthétique du seuil et de son franchissement 

    Directory of Open Access Journals (Sweden)

    Sylvie Castets

    2010-04-01

    Full Text Available Le seuil,abordé en tant que sujet représenté, est ici le moyen d’envisager la question  de la limite et de son dépassement dans le territoire de l’œuvre peinte, de l’installation et de la performance. La fresque de Masaccio, intitulée « Adam et Ève chassés du Paradis », réalisée vers 1425, constitue une étape décisive dans le traitement de l’espace de représentation. La suggestion d’une  profondeur, mais également, d’une épaisseur, apparaît, faisant basculer la peinture vers le naturalisme. Ainsi, au réalisme intellectuel du Moyen Age, se substitue un nouveau mode de figuration. L’artiste de la Renaissance quitte donc un territoire artistique pour explorer et poser les bases d’un art inédit. Dès lors, la toile, telle une zone de friction, se place et agit dans l’interstice séparant l’espace réel et l’espace représenté. La vision du spectateur, face au tableau, franchit ainsi le barrage de l’œuvre pour coloniser une fable topique amenée par l’illusion de la profondeur. La peinture est également le lieu où l’artiste révèle au spectateur, par le biais de stratagèmes plastiques, ses conditions de réalisation. A partir de là, une rupture s’opère entre la représentation et le fait de présenter. Art et vie s’interpénètrent alors, dans des installations ou des performances, offrant au spectateur un lieu milieu, dans lequel il est amené à s’affranchir de ces modèles. L’oeuvre est donc un seuil qu’il faut «traverser pour apprendre la solitude. » (Serres. Elle vibre d’instabilité et cristallise l’état singulier du changement. Enfin, elle conduit inéluctablement vers un devenir autre.The threshold as theme of representation is in this article used as a way to question the limit and its crossing in the territory of the painted work, of the installation and the performance. Masaccio’s fresco “The Expulsion from the Garden of Eden” of 1425 constitutes a decisive

  9. TNIK inhibition abrogates colorectal cancer stemness

    Science.gov (United States)

    Masuda, Mari; Uno, Yuko; Ohbayashi, Naomi; Ohata, Hirokazu; Mimata, Ayako; Kukimoto-Niino, Mutsuko; Moriyama, Hideki; Kashimoto, Shigeki; Inoue, Tomoko; Goto, Naoko; Okamoto, Koji; Shirouzu, Mikako; Sawa, Masaaki; Yamada, Tesshi

    2016-01-01

    Canonical Wnt/β-catenin signalling is essential for maintaining intestinal stem cells, and its constitutive activation has been implicated in colorectal carcinogenesis. We and others have previously identified Traf2- and Nck-interacting kinase (TNIK) as an essential regulatory component of the T-cell factor-4 and β-catenin transcriptional complex. Consistent with this, Tnik-deficient mice are resistant to azoxymethane-induced colon tumorigenesis, and Tnik−/−/Apcmin/+ mutant mice develop significantly fewer intestinal tumours. Here we report the first orally available small-molecule TNIK inhibitor, NCB-0846, having anti-Wnt activity. X-ray co-crystal structure analysis reveals that NCB-0846 binds to TNIK in an inactive conformation, and this binding mode seems to be essential for Wnt inhibition. NCB-0846 suppresses Wnt-driven intestinal tumorigenesis in Apcmin/+ mice and the sphere- and tumour-forming activities of colorectal cancer cells. TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach. PMID:27562646

  10. Inhibition of calcineurin abrogates while inhibition of mTOR promotes regulatory T cell expansion and graft-versus-host disease protection by IL-2 in allogeneic bone marrow transplantation.

    Directory of Open Access Journals (Sweden)

    Atsushi Satake

    Full Text Available Regulatory T cells (Tregs attenuate excessive immune responses, making their expansion beneficial in immune-mediated diseases including allogeneic bone marrow transplantation (BMT-associated graft-versus-host disease (GVHD. We have recently reported that Treg expansion does not require phospholipase Cγ activation when IL-2 is provided. As such, the combination of IL-2 and a calcineurin inhibitor (Cyclosporine A; CsA expands Tregs while inhibiting Tconv proliferation and protects against a mouse model of multiple sclerosis. However, CsA inhibits Treg proliferation in the presence of a TCR stimulus, suggesting that CsA may negatively impact Treg proliferation when they receive strong allogeneic MHC-mediated TCR signals. In this study, we show that CsA inhibits Treg proliferation and inducible Treg generation in allogeneic but not in syngeneic BMT when IL-2 is provided. In contrast to CsA, the mTOR inhibitor (Rapamycin almost completely suppressed IL-2-mediated Treg proliferation. However, CsA and Rapamycin inhibited Treg proliferation to a similar extent when TCR stimulation was provided. Furthermore, Rapamycin promoted Treg expansion and inducible Treg generation in allogeneic BMT recipients treated with IL-2. Consistent with these observations, CsA abrogated while Rapamycin promoted the protective effect of IL-2 on allogeneic BMT-induced GVHD. These results suggest that while CsA permits IL-2-induced Treg proliferation in the syngeneic setting (absence of strong TCR signals, CsA in combination with IL-2 may be detrimental for Treg proliferation in an allogeneic setting. Thus, in allogeneic settings, an mTOR inhibitor such as Rapamycin is a better choice for adjunct therapy with IL-2 in expansion of Tregs and protection against allogeneic BMT-induced GVHD.

  11. Evaluación de anemia ferropénica en la primera infancia del Municipio de Sonsón-Antioquia, 2007

    Directory of Open Access Journals (Sweden)

    Tulia Isabel Castillo Salgado

    2016-08-01

    Full Text Available Objetivo: Determinar la prevalencia de anemia por deficiencia de hierro en niños de la primera infancia del municipio de Sonsón – Antioquia, en el año 2007. Metodología: Se realizó un estudio descriptivo transversal en 391 niños de 0 a 84 meses de edad del Municipio de Sonsón, Antioquia. Se estudiaron los parámetros de hemoglobina y ferritina sérica utilizando puntos de corte de la Organización Mundial de la Salud (OMS. Se calcularon las medidas de frecuencia y de resumen y los intervalos de confianza para proporciones y las pruebas de estadística paramétrica y no paramétrica. Resultados: La prevalencia de anemia ferropénica fue de 4,3% y la media de ferritina sérica y de hemoglobina para la población del estudio fue de 29,9 ng/mL y 12,6 g/dL respectivamente. Adicionalmente se halló significancia estadística de la prevalencia de anemia ferropénica por grupo de edad (p<0,0001; pero no se encontró significancia estadística de la  prevalencia de anemia con el sexo (p= 1,0000.  Conclusión: La prevalencia de anemia ferropénica en los niños de la primera infancia del Municipio de Sonsón fue baja de acuerdo con los parámetros de hemoglobina y ferritina sérica establecidos por la OMS, hay variación de la anemia ferropénica por grupo de edad pero no por sexo.

  12. Genetic data and de novo mutation rates in father-son pairs of 23 Y-STR loci in Southern Brazil population.

    Science.gov (United States)

    Da Fré, Nicole Nascimento; Rodenbusch, Rodrigo; Gastaldo, André Zoratto; Hanson, Erin; Ballantyne, Jack; Alho, Clarice Sampaio

    2015-11-01

    We evaluated haplotype and allele frequencies, as well as statistical forensic parameters, for 23 Y-chromosome short tandem repeats (STRs) loci of the PowerPlex®Y23 system (DYS19, DYS385a/b, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, Y-GATA-H4, DYS481, DYS533, DYS549, DYS570, DYS576, DYS643) in a sample of 150 apparently healthy males, resident in South Brazil. A total of 150 different haplotypes were identified. The highest gene diversity (GD) was observed for the single locus marker DYS570 (GD = 0.7888) and for a two-locus system DYS385 (GD = 0.9009). We also examined 150 father-son pairs by the same system, and a total of 13 mutations were identified in the 3450 father-son allelic transfers, with an overall mutation rate across the 23 loci of 3.768 × 10(-3) (95% CI: 3.542 × 10(-3) to 3.944 × 10(-3)). In all cases there was only one locus mutated with gain/loss of repeats in the son (5 one-repeat gains, and 7 one-repeat and 1 two-repeat losses); we observed no instances of mutations involving a non-integral number of repeats. PMID:25391811

  13. Daniel John Cunningham (1850-1909): anatomist and textbook author, whose sons achieved distinction in the Army, Navy and Indian Medical Service.

    Science.gov (United States)

    Kaufman, Matthew H

    2008-02-01

    Daniel John Cunningham was a son of the manse. His father John (1819-93) was the parish priest at Crieff, Perthshire from 1845 and was to remain there for 41 years. In 1886 he was appointed Principal of St Mary's College of the University of St Andrews and Moderator of the Church of Scotland. Daniel was educated at Crieff Academy before he progressed to the University of Edinburgh. He graduated MB CM with First-class Honours in 1874 and then proceeded MD in 1876 when he was awarded a Gold Medal for his thesis. He acted as Demonstrator to Professor Turner (1832-1916) in Edinburgh for eight years until 1882 and was then appointed to the Chair of Anatomy at the Royal College of Surgeons of Ireland, in Dublin. After only one year there, he transferred to Trinity College, Dublin, where he occupied a similar position for 20 years. In 1903, on the appointment of Sir William Turner to the post of Principal and Vice-Chancellor of the University of Edinburgh, Daniel was invited to succeed him as Professor of Anatomy in Edinburgh. Daniel held this post until his premature death in 1909. He had three sons and two daughters. Each of his three sons achieved distinction in different fields - one in the Army, another in the Navy and the third in the Indian Medical Service. One of Daniel's daughters married Dr Edwin Bramwell (1873-1952), who was later to occupy the Moncrieff Arnott Chair of Clinical Medicine in the University of Edinburgh.

  14. Poškodbe mladih sadik navadnega divjega kostanja (Aesculus hippocastanum L.) zaradi sončevega ožiga

    OpenAIRE

    Žitnik, Denis

    2014-01-01

    Pri pregledu zdravstvenega stanja drevoreda navadnih divjih kostanjev (Aesculus hippocastanum L.) na Cesti v mestni log v Mestni občini Ljubljana smo opazili številne neprerasle poškodbe na deblih dreves zaradi sončevega ožiga. Za potrebe nadaljnjih raziskav je bilo meseca aprila 2009 iz drevoreda odstranjenih sedem dreves. Drevesa so bila podrobno preiskana, nato pa smo jihrazžagali na kolute iz katerih smo pridobili posamezne vzorce za naše raziskave. Vlažnost lesa smo določili gravimetričn...

  15. The Portrayal of White Organized Racists Characters on Television : How White Organized Racist Characters are Portrayed in Oz, Sons of Anarchy, and Justified

    OpenAIRE

    2012-01-01

    The purpose of this thesis is to look at how white organized racist characters are portrayed on television by taking a closer look at the white organized racist characters portrayed in Oz, Sons of Anarchy and Justified. It will look closer at how the social class and social status of these characters have been defined and portrayed. It will also look at how the white organized racist characters perform their gender and what types of masculinity they display, and analyze the usage of racist sy...

  16. Relation entre la carie du blé (Tilletia spp.) et son environnement, et propositions de recherches futures pour des agriculteurs en mode de production biologique

    OpenAIRE

    Vidal, Alix

    2012-01-01

    Le rapport se divise en cinq grandes parties : Présentation du contexte de l’étude, recherche bibliographique, matériel et méthodes, résultats et discussion et enfin, les perspectives pour la recherche future. Cette étude comporte deux objectifs principaux. Le premier est de mettre en relation la carie du blé (causée par Tilletia spp.)avec son environnement au sens large. Le second est de proposer des nouveaux angles d’approches pour la recherche future, en accord avec les agriculteurs en mod...

  17. Funciones del sueño en un auto de Calderón: Sueños hay que verdad son (1670)

    OpenAIRE

    Gilbert, Françoise

    2005-01-01

    International audience SUMMARY:This study seeks to analyze the different functions of dream in the auto of Calderón, Sueños hay que verdad son (1670), which is based on some episodes from Josef's life in Genesis. Beginning with the structuring function of dream, in Bible stories, I study the dramatic function of this motif in this auto, within the sacramental frame of a double reading: historial and allegorical. After first establishing the structure of the work based on its metrical organ...

  18. Proposal of a new model for dose calculation due to the inhalation of Ru-222, Ru-220 and their sons with brief half-life

    International Nuclear Information System (INIS)

    The consequences of the radiation interactions upon the human body are studied. In order to simulate by computer the radiation interaction of the atoms of radon and thoron atoms and their Sons with a brief half life inhaled with the cells, the compartimental dosimetric model is used. The metabolic pathway of those radionuclides is described by continuous medium dynamic differential equation. The energy transfer processes are seen in details. The individual retention function is determined by bio-analysis. The results of internal dosimetry are consistents with the new international recommendations from ICRP-32. (L.F.S.)

  19. Death of a Son is Associated With Risk of Suicide Among Parous Women in Taiwan: A Nested Case-Control Study

    OpenAIRE

    Chen, Chih-Cheng; Kuo, Chien-Chun; Wu, Trong-Neng; Yang, Chun-Yuh

    2012-01-01

    Background The impact of the sex of a deceased child on maternal suicide has not been studied. We examined whether the death of a child, especially a son, increased the risk of suicide among parous Taiwanese women. Methods This matched case-control study was done within a cohort of 1 292 462 Taiwanese women who experienced a first and singleton childbirth between 1 January 1978 and 31 December 1987 and were followed up until 31 December 2008. From the cohort, 2701 suicide cases were identifie...

  20. ¿SON LAS CAJAS DE AHORROS DE CASTILLA Y LEÓN SOCIALMENTE RESPONSABLES?. INFLUENCIA DE SU OBRA SOCIAL EN EL DESEMPEÑO EMPRESARIAL /

    OpenAIRE

    Marbella Sánchez, F.; Martínez Campillo, A.; Cabeza García, L.

    2008-01-01

    Los objetivos de este trabajo son realizar un estudio descriptivo de la evolución del gasto en obra social de las Cajas de Ahorros de Castilla y León durante el periodo 2000-2004, así como analizar el efecto de dicha inversión sobre el desempeño empresarial. Los resultados obtenidos muestran un crecimiento relativamente bajo de la dotación a obra social, siendo el área que más presupuesto recibe la de Cultura y Tiempo Libre, y una influencia positiva y significativa de la misma sobre la cuota...

  1. Influência das vogais na estimulabilidade dos sons líquidos Vowels influence in the stimulability for liquid sounds

    Directory of Open Access Journals (Sweden)

    Márcia Mathias de Castro

    2009-01-01

    Full Text Available OBJETIVO: verificar o número de crianças, entre 5:0 e 11:6 anos, com e sem Transtorno Fonológico, falantes do Português Brasileiro que imitaram corretamente os sons líquidos no teste de estimulabilidade considerando cada uma das vogais subsequentes. MÉTODOS: a estimulabilidade foi medida por uma prova de imitação de 63 sílabas com os sons com as sete vogais orais, em três repetições. Foi analisada a porcentagem de sujeitos que produziu corretamente os sons em função da vogal subsequente. RESULTADOS: o foi o som com mais produções corretas, independente da vogal subsequente; o foi melhor produzido com as vogais subsequentes [ε, ó], parecendo ser a altura da língua em posição média-baixa facilitadora da produção desse som; o foi melhor produzido com as vogais subsequentes arredondadas [o, ó, u] evidenciando que o gesto articulatório de arredondamento dos lábios facilita a produção deste som, assim como a posição média-alta e posterior da língua. CONCLUSÃO: as vogais subsequentes aos sons líquidos estudados evidenciam influências em suas produções, de forma a facilitá-las.PURPOSE: to check the number of children, between 5:0 and 11:6-year old, with and without Phonological Disorder, Brazilian Portuguese speaking children that imitated correctly the liquid sounds in the stimulability test considering each one of the subsequent vowels. METHODS: the stimulability was measured in syllable imitation of 63 syllables with the sounds with seven oral vowels. We analyzed the percentage of subjects that produced correctly the sounds as a function of the subsequent vowel. RESULTS: the was the sound with more correct productions, independent of the sequent vowel; the was better produced with the vowels [ε, ó], and it seems that the medium-lower position height of the tongue is make easier the production of this sound; the was better produced with the vowels [o, ó, u], it seems that the round position of the lips

  2. Diseño de un sistema integrado de aprovechamiento de aguas grises y pluviales en el hotel rural de Son Xotano (Sencelles, Mallorca)

    OpenAIRE

    Ramonell Fernández, Pedro

    2007-01-01

    El presente proyecto estudia y analiza la gestión del agua en una instalación hotelera de pequeña envergadura, con el objetivo de conseguir un ahorro de dicho recurso mediante la reutilización principalmente. La edificación estudiada es el hotel rural Son Xotano****, en el término municipal de Sencelles (Mallorca), ubicado en el centro de la isla. Para conseguir dicho objetivo, se ha basado el trabajo en una de las soluciones que se barajan actualmente para tal fin: el reciclaj...

  3. Parents think their sons are brighter than their daughters: sex differences in parental self-estimations and estimations of their children's multiple intelligences.

    Science.gov (United States)

    Furnham, Adrian; Reeves, Emma; Budhani, Salima

    2002-03-01

    In this study, 156 participants, predominantly White British adults (M age = 44.3 years) rated themselves on overall IQ and on H. Gardner's (1983) 7 intelligence subtypes. Parents (n = 120) also estimated the intelligence of their children. Men's self-estimates were significantly higher than women's (110.15 vs. 104.84). Participants thought their verbal, mathematical, and spatial intelligence scores were the best indicators of their own overall intelligence. Parents estimated that their sons had significantly higher IQs than their daughters (115.21 vs. 107.49). Self-estimates and estimates of children's multiple intelligences were higher for men and sons, significantly so for logical-mathematical and spatial intelligence. Parents rated 2nd-born daughters as having significantly higher verbal and musical intelligence than their male counterparts. Higher parental IQ self-estimates corresponded with higher IQ estimates for children. Results for 1st-born children were clearest and showed the most significant differences. The findings are interpreted in terms of sociocultural and familial influences and the possibility of actual sex differences in particular abilities.

  4. Parents think their sons are brighter than their daughters: sex differences in parental self-estimations and estimations of their children's multiple intelligences.

    Science.gov (United States)

    Furnham, Adrian; Reeves, Emma; Budhani, Salima

    2002-03-01

    In this study, 156 participants, predominantly White British adults (M age = 44.3 years) rated themselves on overall IQ and on H. Gardner's (1983) 7 intelligence subtypes. Parents (n = 120) also estimated the intelligence of their children. Men's self-estimates were significantly higher than women's (110.15 vs. 104.84). Participants thought their verbal, mathematical, and spatial intelligence scores were the best indicators of their own overall intelligence. Parents estimated that their sons had significantly higher IQs than their daughters (115.21 vs. 107.49). Self-estimates and estimates of children's multiple intelligences were higher for men and sons, significantly so for logical-mathematical and spatial intelligence. Parents rated 2nd-born daughters as having significantly higher verbal and musical intelligence than their male counterparts. Higher parental IQ self-estimates corresponded with higher IQ estimates for children. Results for 1st-born children were clearest and showed the most significant differences. The findings are interpreted in terms of sociocultural and familial influences and the possibility of actual sex differences in particular abilities. PMID:11952262

  5. When Parents Separate and One Parent 'Comes Out' as Lesbian, Gay or Bisexual: Sons and Daughters Engage with the Tension that Occurs When Their Family Unit Changes.

    Directory of Open Access Journals (Sweden)

    Siobhán C Daly

    Full Text Available The experiences of Irish sons and daughters born into heterosexually-organised parental partnerships/unions whose parents have separated and one has come out as Lesbian, Gay or Bisexual (LGB were explored through a grounded theory approach. 15 adult children (over the age of 18 years, who varied in age when their parents separated and one disclosed as LGB, were interviewed. The primary concern that emerged centred on participants having to adjust to their parents' being separated, as opposed to their parent being LGB. This involved engaging with the tension that arose from the loss of the parental union, which involved changes to the home environment and adapting to new parental partners and family units. Heightened reflection on sexual orientation and an increased sensitivity to societal LGB prejudice were specifically associated with a parent coming out as LGB. How parents negotiated disclosing the changes to others, the level of support available to parents, and how capable parents were at maintaining the parent-child relationship had an impact on the tension experienced by sons and daughters. Participants moved from initially avoiding and resisting the family changes that were occurring to gradual consonance with their altered family environments. Concluding directions for research and clinical considerations are suggested.

  6. When Parents Separate and One Parent 'Comes Out' as Lesbian, Gay or Bisexual: Sons and Daughters Engage with the Tension that Occurs When Their Family Unit Changes.

    Science.gov (United States)

    Daly, Siobhán C; MacNeela, Pádraig; MacNeela, Pádriag; Sarma, Kiran M

    2015-01-01

    The experiences of Irish sons and daughters born into heterosexually-organised parental partnerships/unions whose parents have separated and one has come out as Lesbian, Gay or Bisexual (LGB) were explored through a grounded theory approach. 15 adult children (over the age of 18 years), who varied in age when their parents separated and one disclosed as LGB, were interviewed. The primary concern that emerged centred on participants having to adjust to their parents' being separated, as opposed to their parent being LGB. This involved engaging with the tension that arose from the loss of the parental union, which involved changes to the home environment and adapting to new parental partners and family units. Heightened reflection on sexual orientation and an increased sensitivity to societal LGB prejudice were specifically associated with a parent coming out as LGB. How parents negotiated disclosing the changes to others, the level of support available to parents, and how capable parents were at maintaining the parent-child relationship had an impact on the tension experienced by sons and daughters. Participants moved from initially avoiding and resisting the family changes that were occurring to gradual consonance with their altered family environments. Concluding directions for research and clinical considerations are suggested. PMID:26710277

  7. AutoCAD 3D pour l'architecture et le design : conception d'une maison et de son mobilier

    CERN Document Server

    Riccio, Michel

    2010-01-01

    Module 3D d'AutoCAD, logiciel leader de dessin assisté par ordinateur, AutoCAD 3D est l'outil indispensable des architectes qui souhaitent présenter leurs travaux en trois dimensions. Voici donc un livre très pédagogique qui leur fera découvrir ses principales fonctionnalités (versions 2006 à 2010) à travers un projet de conception de maison contemporaine. Riche de 700 plans, schémas et dessins, il explique quels outils employer pour modéliser les façades d'une villa, sa piscine et sa terrasse, ainsi que son architecture intérieure et son mobilier. Dès les premières pages, le lecteur se retrouve ainsi plongé dans la pratique, voyant se construire au fil des 17 ateliers un édifice tridimensionnel complexe, qu'il aura la satisfaction d'avoir créé lui-même. A qui s'adresse ce livre ? Aux bureaux d'architectes qui souhaitent présenter leurs projets en 3D ; À tous les étudiants en écoles d'architecture ; Aux utilisateurs 2D d'AutoCAD qui désirent connaître les fonctions 3D de ce logiciel.

  8. 论余华小说中的父子关系%On Father and Son in YuHua's Works

    Institute of Scientific and Technical Information of China (English)

    阮崇友; 刘永松

    2015-01-01

    余华小说中的父子关系从充满冷漠、仇视、暴力、死亡的怪异的父子关系,到善良坚强,关爱呵护血浓于水的舐犊情深。形态各异,变化万千,给读者带来了阅读上的革命,本文论述了余华作品中的种种父子关系。从这些关系中让我们更好地了解余华及余华的小说。%In YuHua's works,the relationship between father and son presents different patterns,various changes,which en-dues the readers a revolution in reading.The relationship varys from indifference,hatred,violence,the strange death to kind-ness,strong will,loving care,and the viewpoint of blood is thicker than water and so on.This paper discusses a variety of the relationship between father and son in YuHua's works,from which the readers can understand the author and his works better.

  9. Deletion involving D15S113 in a mother and son without Angelman syndrome: Refinement of the Angelman syndrome critical deletion region

    Energy Technology Data Exchange (ETDEWEB)

    Michaelis, R.C.; Skinner, S.A.; Lethco, B.A. [Greenwood Genetic Center, SC (United States)] [and others

    1995-01-02

    Deletions of 15q11-q13 typically result in Angelman syndrome when inherited from the mother and Prader-Willi syndrome when inherited from the father. The critical deletion region for Angelman syndrome has recently been restricted by a report of an Angelman syndrome patient with a deletion spanning less than 200 kb around the D15S113 locus. We report here on a mother and son with a deletion of chromosome 15 that includes the D15S113 locus. The son has mild to moderate mental retardation and minor anomalies, while the mother has a borderline intellectual deficit and slightly downslanting palpebral fissures. Neither patient has the seizures, excessive laughter and hand clapping, ataxia or the facial anomalies which are characteristic of Angelman syndrome. The proximal boundary of the deletion in our patients lies between the D15S10 and The D15S113 loci. Our patients do not have Angelman syndrome, despite the deletion of the D15S113 marker. This suggests that the Angelman syndrome critical deletion region is now defined as the overlap between the deletion found in the previously reported Angelman syndrome patient and the region that is intact in our patients. 28 refs., 6 figs.

  10. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α

    Directory of Open Access Journals (Sweden)

    Wang L

    2015-07-01

    in osteoclast precursor cells; the inhibitory effect was abolished by methyl-piperidino-pyrazole but not the estrogen receptor β antagonist or androgen receptor antagonist.Conclusion: These results collectively suggest that administration of BSNXD presents inhibitory effects on osteoclast differentiation by abrogating the RANKL-induced nuclear factor of activated T-cells, cytoplasmic 1 and NF-κB signaling pathways downstream of estrogen receptor α, thereby contributing to the inhibitory effect on bone resorption.Keywords: herbal formula, osteoclastogenesis, estrogen receptor α, NF-κB, NFATc1

  11. Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

    OpenAIRE

    Peterson, Luke F.; Boyapati, Anita; Ahn, Eun-Young; Biggs, Joseph R.; Okumura, Akiko Joo; Lo, Miao-Chia; Yan, Ming; Zhang, Dong-Er

    2007-01-01

    Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to unders...

  12. El delito de aborto son inconstitucionales (los abortos son homicidios

    Directory of Open Access Journals (Sweden)

    Gustavo González Solano

    2002-09-01

    Full Text Available El voto 2306-2000 (sobre la fecundación in vitro de la Sala Constitucional, ha dado un giro "copernicano" al concepto de "persona" y la protección que a ellas se les ofrece, en el campo jurídico. La Sala generalizó el uso de la palabra "persona" a todos los seres humanos ya nacidos y a "no nacidos" llamados en nuestra legislación "fetos". Tal definición, modifica de plano el Código Civil que expresa: "La existencia de lapersonafisicaprincipia al nacer viva... "y con ello, toda la aplicación de la materia no solo civil sino también la de Derecho de Familia, al otorgarle una serie de derechos y obligaciones a esta categoría de seres humanos (los no nacidos que antes no les ofrecía.The 2306-2006 vote of the Costa Rican Constitutional Court ( about the in vitro fecundation, has made "Copernicans" revolution on the concept of "human person" and the legal protection given to them. The Court spread the use of the word "human person" to every human being including the unborn, called in our legislation, "fetus". This definition modified the Civil Code which expresses " The existence of the human person are begins at a living birth" and affects as well the Family Code because the rights and obligations now given to the unborn.

  13. El delito de aborto son inconstitucionales (los abortos son homicidios)

    OpenAIRE

    Gustavo González Solano

    2002-01-01

    El voto 2306-2000 (sobre la fecundación in vitro) de la Sala Constitucional, ha dado un giro "copernicano" al concepto de "persona" y la protección que a ellas se les ofrece, en el campo jurídico. La Sala generalizó el uso de la palabra "persona" a todos los seres humanos ya nacidos y a "no nacidos" llamados en nuestra legislación "fetos". Tal definición, modifica de plano el Código Civil que expresa: "La existencia de lapersonafisicaprincipia al nacer viva... "y con ello, toda la aplicación ...

  14. Performance of brain MRI of a two generation father-and-son family with long-term smoking caffeinum natrio benzoicum

    Institute of Scientific and Technical Information of China (English)

    SUN Wan-li; ZHANG Li-fang; LIU Hong; ZHAO Li-yun; XING Yu-ping; YUAN Ning

    2010-01-01

    @@ Since the 1970s, some people in north, northeast,northwest areas began to smoke caffeinum natrio benzoicum (CNB) and started to abuse CNB. As a common ingredient that can be found in drugs or drinks,many studies on the safety of CNB have been investigated, but no one has shown significant abnormality in the brain of a CNB abuser by using neuroimaging. In our study, three subjects from of a two generation father-and-son family with long-term smoking CNB were enrolled. Combining with the clinical data and taking the cocaine animal trial model and toxicology as the reference, we wanted to observe the performance of brain MRI and MRS of patients with long-term smoking CNB.

  15. Conceptualisation de l'esprit entrepreneurial et identification des facteurs de son développement à l'université.

    OpenAIRE

    Rajhi, Nadia,

    2011-01-01

    Cette thèse est consacrée d'une part à la conceptualisation de l'esprit entrepreneurial et d'autre part à l'identification des facteurs de son développement à l'université. L'étude théorique nous a amené à considérer l'esprit entrepreneurial comme un processus mental composé d'un ensemble d'attitudes et de sentiments de compétence favorable à une orientation entrepreneuriale. L'université à côté d'autres facteurs de socialisation pourrait le développer. Et ce en évoluant vers une université e...

  16. Integración, turismo y discapacidad: ¿son accesibles los hoteles para las personas con discapacidad física?

    Directory of Open Access Journals (Sweden)

    Raquel Suriá Martínez

    2014-01-01

    Full Text Available En este estudio examinamos los obstaculos que se encuentran las personas con discapacidad física durante su estancia en un hotel. Se examinó la influencia del género y edad. Participaron 41 personas con discapacidad motora pertenencientes a la confederación de discapacitados de la provincia de Alicante. Utilizamos un cuestionario diseñado had hoc para el estudio. Los resultados indicaron que la mayor dificultad que los participantes encuentran en los hoteles son los escalones y el personal. se encontraron diferencias según el género y edad. Ello revela la existencia de obstáculos que impiden la accesibilidad hotelera para las personas con discapacidad. Estas dificultades pueden solucionarse con una adecuada predisposición por parte de los responsables hoteleros.

  17. 3 minutes pour développer son intelligence émotionnelle: journal filmé avec une classe d'enfants porteurs d'un handicap physique

    OpenAIRE

    Kozma, Kim; Savoy, Bernard

    2015-01-01

    Comment faire entrer le bonheur, le bien-être et le plaisir d’être ensemble dans ma classe d’enseignement spécialisé avec des enfants porteurs d’un handicap physique ? A la recherche d’une approche différente qui valorise l’humain plutôt que ses performances, je me suis intéressée à une autre forme d’intelligence. Le bonheur est aujourd’hui un sujet qui fascine le grand public et les scientifiques. Que de méthodes pour trouver son équilibre ! Une seule constance : cet équilibre passe par l’ac...

  18. ¿Qué es la investigación en Educación Matemática y cuáles son sus resultados? I

    OpenAIRE

    Gómez, Pedro

    1994-01-01

    Entre el 8 y el 11 de mayo de 1994 tuvo lugar en la Universidad de Maryland la Conferencia ICMI 1994 alrededor del tema ÀQué es la investigación en educación matemática y cuáles son sus resultados? El ICMI es la principal organización internacional de educación matemática. Además de ser el organizador de los ICME, los congresos mundiales de educación matemática que tienen lugar cada cuatro años, el ICMI organiza estudios sobre diferentes temas de la educación matemática. Estos estudios toman ...

  19. Rich Man's Sons and Daughters: Dance with the Soul%《财主底儿女们》:舞蹈着的心灵

    Institute of Scientific and Technical Information of China (English)

    陈传芝

    2012-01-01

    Rich Man's Sons and Daughters presented the spirit as "dance with the soul", which shows not only the vigorous action of the characters, the struggle of the wilderness, backwardness and hesitation of the heavy affection; but also shows the clumsy narration of the young authors.%《财主底儿女们》所呈现的精神样态为“舞蹈着的心灵”,这既表现为作品人物“前进”中的奋力突进、旷野中的挣扎、沉重的温柔所带来的滞缓与迟疑,又表现为年轻的作者呈舞蹈之姿的稚拙叙事。

  20. Ferney et son nouveau visage

    CERN Multimedia

    2004-01-01

    Ferney-Voltaire's third annual fête in h. of Voltaire will take place on 26 June. The theme this year is Newton and the emblem is the apple. CERN, which is celebrating its fiftieth anniversary this year, will be participating in the fête, and has sent a magnet to be displayed outside the Town Hall (1 paragraph)

  1. Cuando son muchas las voces

    Directory of Open Access Journals (Sweden)

    Cruz, Manuel

    2003-12-01

    Full Text Available The work departs from an approach to the genesis of the concept of responsibility. Some features of the concept that have today become obvious can already come into sight in this first approach. The work devotes itself then to point out the implications (and, most of all, the consequences involved in openly ascribing responsibility to the Modern Age and to the rise of industrial civilization. One of these main consequences is perhaps to have to deal with a number of theoretical topics in a necessary connexion with another axial topic of modern thought, namely, identity. Besides, the essay points also to a number of topics, such as the problem of the alleged collective responsibilities and also that of evil, just to quote two of them, whose magnitude may serve as an indicator to the relevance of the concept of responsibility in contemporary thought.

    Tras una inicial aproximación a la génesis del concepto de responsabilidad, génesis en la que se empiezan a percibir algunos de los rasgos del mismo que terminarán por hacerse explícitos en nuestros días, el trabajo se centra en señalar las implicaciones (y, sobre todo, las consecuencias que tiene adscribir decididamente la responsabilidad a la época moderna y, en concreto, al surgimiento de la civilización industrial. Acaso una de las más importantes sea la de obligarnos a plantear toda una serie de asuntos en conexión necesaria con otro tema-eje del pensamiento moderno, el de la identidad. Junto a dicho tema, en el texto quedan apuntados otros, como el de la justa escala en la que abordar tales asuntos (o, lo que viene a ser lo mismo, el problema de las presuntas responsabilidades colectivas o el del mal, por citar sólo dos, cuya envergadura puede servir como indicador de la importancia que presenta el concepto de responsabilidad en el pensamiento contemporáneo.

  2. ¿Son viables los créditos ects otorgados a las matemáticas en los nuevos planes de estudio de LADE?

    Directory of Open Access Journals (Sweden)

    Álvarez Martínez, Pedro

    2006-01-01

    Full Text Available EL nuevo plan de estudios para la Administración y Dirección de Empresas (ADE va encaminado a resolver los problemas de la vida real en las empresas. Las disciplinas que lo contemplan están reguladas por los créditos ECTS (European Credit Transfer System, establecidos por la Commission of the European Community, con objeto de proporcionar procedimientos comunes que garanticen un reconocimiento académico de los estudios en los distintos paises que la integran. La presencia de las Matemáticas en los Planes es debido a su carácter instrumental, sus contenidos son utilizados por la demás disciplinas y le otorga el papel de ser una asignatura de servicio y “transversal”. El presente trabajo desarrolla una metodología empírica, determinando la temporización docente/discente de los contenidos matemáticos que son utilizados por todas las disciplinas que componen la titulación de ADE. Dichos contenidos han sido contabilizados y cuantificado en términos de créditos ECTS, aplicando los criterios que caracterizan su definición. El resultado obtenido pone de manifiesto que los créditos del nuevo plan no satisfacen las exigencias que caracterizan a los créditos ECTS para el aprendizaje de las matemáticas. Dado que los contenidos matemáticos no han cambiado, por exigencias de las disciplinas de ADE, los resultados obtenidos con datos experimentales, tras la reducción de horas de docencia, muestran lo siguiente: Con el Plan del 1973 (10 horas semanales de clase de Matemáticas se necesitaban 3 convocatorias para aprobar, con el plan actual (4 horas semanales de clase se necesitan 6 convocatorias. La reducción ha supuesto para el alumno un incremento de año y medio de estancia en la universidad, y como consecuencia aumenta el coste. Estudiar matemáticas para ADE era mas barato “antes” que “ahora”. La propuesta de los nuevos planes hace inviable el aprendizaje de las matemáticas en ADE.

  3. EXPLICAR LA CALIDAD DEMOCRÁTICA: ¿QUÉ TAN RELEVANTES SON LAS TRADICIONES AUTORITARIAS? Explaining Democratic Quality: How Relevant is the Authoritarian Legacy?

    Directory of Open Access Journals (Sweden)

    Leonardo Morlino

    2007-01-01

    Full Text Available Esta es una versión revisada de la lectura abierta dada por el autor el año 2004, en la conferencia de la sociedad italiana de Ciencia política en Padua. En la primera sección se discute la principal definición de democracia y calidad democrática, como estado de derecho, accountability electoral, accountability interins titucional, responsiveness, libertad y equidad/solidaridad. En la segunda parte surge una pregunta clave: si nosotros quisiéramos explicar la calidad de la democracia, ¿cuán relevantes son las tradiciones políticas previas? también son sugeridos otros factores explicativos que complementan el rol de los legados autoritarios, proponiendo pequeñas hipótesis clave. En la última sección se analiza el impacto del legado autoritario sobre la calidad de las democracias contemporáneas en países del sur de Europa como Portugal, España e Italia y el Cono Sur de Latinoamérica tal como Chile, Argentina, Uruguay y BrasilThis is the revised draft ofthe opening lecture given by the author atthe 2004 Conference of Italian Society of Political Science in Padua. Inthe first sectionthe main definitions of democracy and democratic qualities rule of law, electoral accountability, inter-ins titutional accountability, responsiveness, freedom and equality/solidarity are discussed. Inthe second a key ques tion is addressed: if we would liketo explainthe qualities of a democracy how much arethe previous politicaltraditions ofthe country relevant? Other explanatory factors, which complementthe role of an authoritarian legacy, are also sugges ted and a few key hypotheses are proposed.the final section does not provide any comprehensive explanation, but analyses ofthe impact of authoritarian legacy in a few countries of Southern Europe, such as Portugal, Spain, and Italy (but not Greece where it is not relevant and inthe Southern Cone as Chile, Argentina, Uruguay, Brazil, wherethe quality of contemporary democracies is ques tioned

  4. (Alpha, gamma) irradiation effect on the alteration of high-level radioactive wastes matrices (UO{sub 2}, hollandite, glass SON68); Effet de l'irradiation (alpha, gamma) sur l'alteration des matrices de dechets nucleaires de hautes activites (UO{sub 2}, hollandite, verre SON68)

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, T

    2007-06-15

    The aim of this work is to determine the effect of irradiation on the alteration of high level nuclear waste forms matrices. The matrices investigated are UO{sub 2} to simulate the spent fuel, the hollandite for the specific conditioning of Cs, and the inactive glass SON68 representing the nuclear glass R7T7) The alpha irradiation experiments on UO{sub 2} colloids in aqueous carbonate media have enabled to distinguish between the oxidation of UO{sub 2} matrix as initial and dissolution as subsequent step. The simultaneous presence of carbonate and H{sub 2}O{sub 2} (product resulting from water radiolysis) increased the dissolution rate of UO{sub 2} to its maximum value governed by the oxidation rate. ii) The study of hollandite alteration under gamma irradiation confirmed the good retention capacity for Cs and Ba. Gamma irradiation had brought only a little influence on releasing of Cs and Ba in solution. Electronic irradiation had conducted to the amorphization of the hollandite only for a dose 1000 times higher than the auto-induced dose of Ba over millions of years. iii) The experiences of glass irradiation under alpha beam and of helium implantation in the glass SON68 were analyzed by positon annihilation spectroscopy. No effect has been observed on the solid surface for an irradiation dose equal to 1000 years of storage. (author)

  5. Crustal thickness mapping in Raipur–Katni area of Narmada–Son lineament in central India derived from 3D Euler deconvolution of magnetic data

    Indian Academy of Sciences (India)

    G K Ghosh; C L Singh

    2013-10-01

    The Narmada–Son lineament (NSL) is one of the most prominent tectonic features which divides the Indian peninsula into two subcontinents, northern and southern India since Precambrian times. The area is seismically active and geologically complex with different geological formations. Magnetic data divides the area into two parts and more prominent magnetic highs are observed near Tikwa, Mau and Amarpur regions with 800, 600 and 400 nT, respectively due to the presence of the crystalline basement rock. Tectonic resettlement and lithological changes causes upwarpment of Mahakoshal rocks. In the present study, magnetic data interpretation is carried out for locating depth of causative body and delineating structural fault/dyke boundaries using Euler deconvolution technique. Most of the faults are oriented in the ENE–WSW direction; however, few more faults are identified which are oriented in the SE to NW direction. These fault patterns suggest that the area is exaggerated by tectonic turmoil and distressed both sedimentary to basement rocks isolating the area into numerous faulted blocks. The maximum depths (< 4.5 km) observed at Katni and Umaria area and moderate depths (between 4.0 and 4.5 km) observed towards east of Katni, Ramnagar, Burwa and east of Umaria and Sarna area.

  6. Synthesis of the S-only 122,123,124Te Isotopes and the Selective Depletion of 123Te by Electron Capture Process in Massive Stars

    Science.gov (United States)

    Takahashi, K.; Blaum, K.; Novikov, Yu.

    2016-03-01

    We investigate the production ratios of the naturally occurring s-only nuclides {}122-124Te by solving a nuclear network in the mass number 120≤slant A≤slant 124 region under some conditions representing those in the helium-hydrogen inter-shell in low-mass AGB stars as well as those in the helium burning and the carbon burning phases in massive stars. We show that the electron-capture process on 123Te (the natural half-life \\gt {10}16 years) could proceed decisively fast during the late evolutionary phases of massive stars. We thus re-iterate and re-enforce the decades-old notion that detailed analysis of the relative {}122-124Te abundances in due consideration of the selective 123Te depletion in massive stars would set a stringent constraint on the s-process modelings. We stress that the relative abundance ratios of {}122-124Te in the solar system become quite difficult to decipher if the s-process in massive stars contributes significantly to the synthesis of nuclides in this intermediate A region.

  7. 《土生子》与《看不见的人》里的象征艺术%Symbolism in Native Son and Invisible Man

    Institute of Scientific and Technical Information of China (English)

    黄春英

    2007-01-01

    Richard Wright and Ralph Allison were two famous contemporary American black novelists. The frequent use of symbolism is a common feature in their literary writing.Through the analysis of the use of symbolism in Richard Wright's Native Son and Ralph Allison's Invisible Man, the writer reveals that a close link between the two novelists' literary creation is an objective existence which is hard to deny.%理查德·赖特和拉尔夫·埃里森,是美国当代两位最著名的黑人作家.大量运用象征,是他们创作的一个共同点.本文主要通过对赖特和埃里森这两部小说里象征艺术的对比分析,指出两位作家创作的密切联系的确是难以否认的客观存在.

  8. Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.

    Science.gov (United States)

    Vo, Uybach; Vajpai, Navratna; Flavell, Liz; Bobby, Romel; Breeze, Alexander L; Embrey, Kevin J; Golovanov, Alexander P

    2016-01-22

    The activity of Ras is controlled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the guanine nucleotide exchange factor Son of Sevenless (Sos). The details of Sos binding, leading to nucleotide exchange and subsequent dissociation of the complex, are not completely understood. Here, we used uniformly (15)N-labeled Ras as well as [(13)C]methyl-Met,Ile-labeled Sos for observing site-specific details of Ras-Sos interactions in solution. Binding of various forms of Ras (loaded with GDP and mimics of GTP or nucleotide-free) at the allosteric and catalytic sites of Sos was comprehensively characterized by monitoring signal perturbations in the NMR spectra. The overall affinity of binding between these protein variants as well as their selected functional mutants was also investigated using intrinsic fluorescence. The data support a positive feedback activation of Sos by Ras·GTP with Ras·GTP binding as a substrate for the catalytic site of activated Sos more weakly than Ras·GDP, suggesting that Sos should actively promote unidirectional GDP → GTP exchange on Ras in preference of passive homonucleotide exchange. Ras·GDP weakly binds to the catalytic but not to the allosteric site of Sos. This confirms that Ras·GDP cannot properly activate Sos at the allosteric site. The novel site-specific assay described may be useful for design of drugs aimed at perturbing Ras-Sos interactions.

  9. Sex allocation and secondary sex ratio in Cuban boa ( Chilabothrus angulifer): mother's body size affects the ratio between sons and daughters

    Science.gov (United States)

    Frynta, Daniel; Vejvodová, Tereza; Šimková, Olga

    2016-06-01

    Secondary sex ratios of animals with genetically determined sex may considerably deviate from equality. These deviations may be attributed to several proximate and ultimate factors. Sex ratio theory explains some of them as strategic decisions of mothers improving their fitness by selective investment in sons or daughters, e.g. local resource competition hypothesis (LRC) suggests that philopatric females tend to produce litters with male-biased sex ratios to avoid future competition with their daughters. Until now, only little attention has been paid to examine predictions of sex ratio theory in snakes possessing genetic sex determination and exhibiting large variance in allocation of maternal investment. Cuban boa is an endemic viviparous snake producing large-bodied newborns (˜200 g). Extremely high maternal investment in each offspring increases importance of sex allocation. In a captive colony, we collected breeding records of 42 mothers, 62 litters and 306 newborns and examined secondary sex ratios (SR) and sexual size dimorphism (SSD) of newborns. None of the examined morphometric traits of neonates appeared sexually dimorphic. The sex ratio was slightly male biased (174 males versus 132 females) and litter sex ratio significantly decreased with female snout-vent length. We interpret this relationship as an additional support for LRC as competition between mothers and daughters increases with similarity of body sizes between competing snakes.

  10. Nommer le conflit. Le cas de l’Alsace pendant son annexion de fait au Troisième Reich, 1940-1945

    Directory of Open Access Journals (Sweden)

    Anne-Ségolène Verneret

    2011-12-01

    Full Text Available L’étude des comportements et opinions de la population en Alsace entre 1940 et 1945 fait appel à la nécessité de nommer une conflictualité parfois floue, ambivalente et qui évolue au cours de la période. Il convient de s’interroger sur l’adaptation des outils de définition des comportements développés en France et en Allemagne pour la situation alsacienne pendant l’annexion de fait de son territoire.   Alsace 1940-1945, oppositions au nazisme, comportements collectifsDie Erforschung des Verhaltens und der Meinung der Bevölkerung im Elsass zwischen 1940-1945 bringt die Notwendigkeit mit sich, eine zuweilen undurchsichtige, zweideutige Konfliktträchtigkeit zu benennen, die sich im Zeitraum der Annektierung zudem entwickelte. Die methodischen Werkzeuge zur Definition kollektiven Verhaltens, die in Frankreich und Deutschland für diesen elsässischen Fall entwickelt wurden, müssen hierbei angepasst werden.

  11. n torno a la globalización. ¿Cuáles son los cambios para interpretar las instituciones políticas?

    Directory of Open Access Journals (Sweden)

    Francisco Roberto García Samaniego

    2005-01-01

    Full Text Available Actualmente existen líneas de investigación sobre aquellos fenómenos presentes que son producto de la globalización, los cambios y los efectos que le siguen producen en la política, la sociedad y la cultura. En este caso haremos referencia a lo colectivo, en tanto y en cuanto, trae parejos profundos conflictos afectivos del entorno individual de algunos seres humanos que afrontan dichos cambios que repolitizan lo público. Y dichos efectos globales entorno a la democracia, y sus instituciones, replantea las formas de interpretar el conflicto social, su visión política y sus efectos sociales a largo plazo. Es decir, la globalización económica y tecnológica de los medios y las redes electrónicas permiten una multiculturalidad que hace desestructurar los referentes tradicionales de identidad. Y al desestructurar el sujeto social unificado que representaba las figuras del pueblo y de nación se descubre el carácter conflictivo que hoy adquiere las configuraciones de lo colectivo y de lo público-político.

  12. Evidence for an extensive intrusive component of the Deccan Large Igneous Province in the Narmada Son Lineament region, India from three dimensional magnetotelluric studies

    Science.gov (United States)

    Patro, Prasanta K.; Sarma, S. V. S.

    2016-10-01

    The crustal electrical structure beneath the western segment of Narmada-Son lineament zone in Central India has been imaged using magnetotelluric (MT) data set of 153 stations distributed over a grid (∼7-8 km site spacing). Three dimensional modeling of this data set brought out several major crustal conductors with different geometries at different depth levels in the crustal column. The conductive features, correlating with gravity high anomalies and high seismic velocity zones are interpreted to be mafic-ultramafic bodies derived from mantle. We infer that these bodies represent the intrusive component of the Large Igneous Province (LIP) of the Deccan volcanic episode triggered by the passage of the Indian continent over the Reunion hot spot during the Late Cretaceous. The disposition and the geometry of the subsurface magmatic bodies, which must have served as magma chambers for outpouring of the Deccan lavas, suggest that they are closely related to the plumbing geometry of the LIP of the Deccan volcanic episode.

  13. The incandescent lamps in Mexico; are they really a beneficial technology?; Las lamparas incandescentes en Mexico: son realmente una tecnologia benefica?

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez Rivero, A. G. [Genertek, S.A. de C.V., Mexico, D. F. (Mexico)

    1995-12-31

    The versatility of the incandescent lamps has originated a sustained increment of its population all over the world. Because of its characteristics they continue being irreplaceable in numberless applications, that go from the movies up to the medicine. Nevertheless the greatest population are represented by the incandescent lamps A-19 with the well-known negative effects to the environment and the economy caused by the electric power generation by conventional methods. No doubt about it, the best option to substitute them are the compact fluorescent lamps (CFL), but the economical barriers, the market and the performance do not permit its massive application in Mexico. In this paper a proposal is set forth that might bring high benefits with a minimum investment and rapid implementation. [Espanol] La versatilidad de las lamparas incandescentes ha causado un incremento sostenido de su poblacion en todo el mundo. Dadas sus caracteristicas continua siendo insustituible en un sinnumero de aplicaciones, que van desde el cine hasta la medicina. Sin embargo, la mayor poblacion la representan las ineficientes lamparas incandescentes A19 con los consabidos efectos negativos en el medio ambiente y la economia, causados por la generacion de energia electrica por medios convencionales. Sin duda, la mejor opcion para sustituirlas son las lamparas compacto fluorescentes (LCF), pero las barreras economicas, de mercado y de desempeno no permiten su aplicacion masiva en Mexico. En este trabajo se hace una propuesta que puede permitir grandes beneficios con minima inversion y rapida implementacion.

  14. 父与子的神话:霍尔顿的双重身份%A Modern Father-Son Myth: Dual Identities of Holden Caulfield

    Institute of Scientific and Technical Information of China (English)

    罗灿

    2006-01-01

    霍尔顿体现了一个成长中的少年的种种问题:厌恶成人世界,不愿长大,急切地在寻找一个"父亲"来指导未来的生活.虽然寻找精神上的父亲是徒劳的,霍尔顿自己却在不知不觉中充当了父亲的角色,具有敏锐的观察力,不断地试图去关怀他人,保护他人.儿子和父亲两种截然不同甚至有些矛盾的角色同时存在于霍尔顿身上,使其形象复杂,充满争议,同时也正是其魅力所在.%As a teenager,Holden Caulfield complains about the phoniness of adult world and searches desperately for a spiritual father who can help him cross the road,that is,grow up without losing his innocence.Yet at the same time,as he himself dreams,Holden Caulfield is a catcher,or a father figure who offers facilitating and guiding help.As a son figure and father figure combined,Holden is an entity of contradiction.The success and controversy of Holden in part consist in his very contradiction and inexplicability.

  15. Materials characterization activities for %E2%80%9CTake Our Sons&Daughters to Work Day%E2%80%9D 2013.

    Energy Technology Data Exchange (ETDEWEB)

    Mowry, Curtis Dale; Pimentel, Adam S.; Sparks, Elizabeth Schares; Hanlon, Brittany Paula

    2013-09-01

    We created interactive demonstration activities for Take Our Daughters&Sons to Work Day (TODSTWD) 2013 in order to promote general interest in chemistry and also generate awareness of the type of work our laboratories can perform. %E2%80%9CCurious about Mars Rover Curiosity?%E2%80%9D performed an elemental analysis on rocks brought to our lab using the same technique utilized on the planet Mars by the NASA robotic explorer Curiosity. %E2%80%9CFood is Chemistry?%E2%80%9D utilized a mass spectrometer to measure, in seconds, each participant's breath in order to identify the food item consumed for the activity. A total of over 130 children participated in these activities over a 3 hour block, and feedback was positive. This document reports the materials (including handouts), experimental procedures, and lessons learned so that future demonstrations can benefit from the baseline work performed. We also present example results used to prepare the Food activity and example results collected during the Curiosity demo.

  16. Des sons et des esprits-maîtres en Amazonie amérindienne Sounds and master-spirits in native Amazonia

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Chaumeil

    2010-09-01

    Full Text Available Partant d’un examen comparatif des terminologies concernant la notion d’esprits-maîtres et l’agentivité dans diverses régions des basses terres amazoniennes, l’article s’attache ensuite à décrire plus précisément les formes particulières — essentiellement sonores — de communication et de contrôle des esprits chez les Yagua de l’Amazonie péruvienne. Cet examen permet de saisir l’importance du champ sonore et de la maîtrise des sons dans ces cultures comme l’un des éléments constitutifs des formes de contrôle et de communication avec les non-humains.Beginning with a comparative examination of terminology related to the notion of master-spirits and agency in diverse regions of the Amazonian lowlands, the article then attempts to more precisely describe the particular, essentially sonorous forms of spirit communication and control used among the Yagua of the Peruvian Amazon. This examination enables an understanding of how the sound field and sound mastering are important elements constituting forms of control and forms of communication with non-humans.

  17. Late Pleistocene monsoon variability in northwest Thailand: an oxygen isotope sequence from the bivalve Margaritanopsis laosensis excavated in Mae Hong Son province

    Science.gov (United States)

    Marwick, Ben; Gagan, Michael K.

    2011-10-01

    Long, continuous records of Late Quaternary environmental change are rare in Southeast Asia, yet they are crucial for understanding the nature of early human dispersal and occupation in the Australasian region. We present a new record of palaeomonsoon activity extending back to 35,000 BP (years before the present), based on the analysis of oxygen isotope ratios (δ 18O) in the freshwater bivalve Margaritanopsis laosensis excavated from the Tham Lod and Ban Rai rockshelters in Mae Hong Son Province, northwest Thailand. Long-term changes in the M. laosensis δ 18O record reflect changes in the δ 18O of the river water in which these organisms grew, and correlate well with changes in speleothem δ 18O records of east Asian monsoon rainfall from Hulu Cave and Dongge Cave in China. The new northwest Thailand δ 18O sequence indicates wetter and relatively unstable climatic conditions from 35,000 to 20,000 BP, followed by drier conditions from 20,000 to 11,500 BP. A period of peak aridity occurred around 15,600 BP during Heinrich Event 1, suggesting that the intertropical convergence zone shifted southward when the North Atlantic region cooled. However, there is little evidence for the Younger Dryas event at ˜12,800-11,500 BP. After 9,800 BP, precipitation increased substantially and climatic variability declined. Our findings provide an improved baseline against which to gauge interactions between early humans and climate change in Southeast Asia. For example, there was no significant change in the prehistoric flake stone technology used at Tham Lod and Ban Rai despite the bivalve δ 18O evidence for substantial climate change in the region. Also, the climatic impact of the Younger Dryas event appears to have been less intense in northwest Thailand compared to the cooling and drying observed in China, and may explain why agriculture made a relatively late appearance in Thailand, possibly involving migrants from China.

  18. Secondary phase formation and the microstructural evolution of surface layers during vapor phase alteration of the French SON 68 nuclear waste glass at 200 degrees C

    International Nuclear Information System (INIS)

    The SON 68 inactive open-quotes R7T7close quotes composition is the French reference glass for the LWR nuclear waste glass. Vapor phase alteration was used to accelerate the reaction progress of glass corrosion and to develop the characteristic suite of secondary, alteration phases. Extensive solid-state characterization (AEM/SEM/HRTEM) was completed on six inactive R7T7 waste glasses which were altered in the presence of saturated water vapor (200 degrees C) for 91, 241, 908, 1000, 1013, and 1021 days. The AEM samples were examined in cross-section (lattice-fringe imaging, micro-diffraction, and quantitative thin-film EDS analysis). The glass monoliths were invariably covered with a thin altered rind. The layer became thicker with time: 0.5 μm for 22 days; 4 μm for 91 days; 6 μm for 241 days; 10 μm for 908 days; 26 μm for 1013 days; and 2TeO3 and (Ca,Sr)Mo3O9(OH)2, were found within the inner zones of surface layers, and they must have nucleated in situ, indicating that Ag, Te, Sr, and Mo can be retained within the surface layer. The majority of the surface layer volume is composed of two morphologically and chemically different structures: one consists of well-crystallized fibrous smectite aggregates occurring along with cavities, the A-domain; and the other consists of poorly-crystallized regions containing needle-like smectite (montmorillonite) crystallites, a silica-rich amorphous matrix, and possibly ZrO2 particles, the B-domain

  19. Contribution of an aged microenvironment to aging-associated myeloproliferative disease.

    Directory of Open Access Journals (Sweden)

    Virag Vas

    Full Text Available The molecular and cellular mechanisms of the age-associated increase in the incidence of acute myeloid leukemia (AML remain poorly understood. Multiple studies support that the bone marrow (BM microenvironment has an important influence on leukemia progression. Given that the BM niche itself undergoes extensive functional changes during lifetime, we hypothesized that one mechanism for the age-associated increase in leukemia incidence might be that an aged niche promotes leukemia progression. The most frequent genetic alteration in AML is the t(8;21 translocation, resulting in the expression of the AML1-ETO fusion protein. Expression of the fusion protein in hematopoietic cells results in mice in a myeloproliferative disorder. Testing the role of the age of the niche on leukemia progression, we performed both transplantation and in vitro co-culture experiments. Aged animals transplanted with AML1-ETO positive HSCs presented with a significant increase in the frequency of AML-ETO positive early progenitor cells in BM as well as an increased immature myeloid cell load in blood compared to young recipients. These findings suggest that an aged BM microenvironment allows a relative better expansion of pre-leukemic stem and immature myeloid cells and thus imply that the aged microenvironment plays a role in the elevated incidence of age-associated leukemia.

  20. Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

    Science.gov (United States)

    Minucci, S; Nervi, C; Lo Coco, F; Pelicci, P G

    2001-05-28

    Recent discoveries have identified key molecular events in the pathogenesis of acute promyelocytic leukemia (APL), caused by chromosomal rearrangements of the transcription factor RAR (resulting in a fusion protein with the product of other cellular genes, such as PML). Oligomerization of RAR, through a self-association domain present in PML, imposes an altered interaction with transcriptional co-regulators (NCoR/SMRT). NCoR/SMRT are responsible for recruitment of histone deacetylases (HDACs), which is required for transcriptional repression of PML-RAR target genes, and for the transforming potential of the fusion protein. Oligomerization and altered recruitment of HDACs are also responsible for transformation by the fusion protein AML1-ETO, extending these mechanisms to other forms of acute myeloid leukemias (AMLs) and suggesting that HDAC is a common target for myeloid leukemias. Strikingly, AML1-ETO expression blocks retinoic acid (RA) signaling in hematopoietic cells, suggesting that interference with the RA pathway (genetically altered in APL) by HDAC recruitment may be a common theme in AMLs. Treatment of APLs with RA, and of other AMLs with RA plus HDAC inhibitors (HDACi), results in myeloid differentiation. Thus, activation of the RA signaling pathway and inhibition of HDAC activity might represent a general strategy for the differentiation treatment of myeloid leukemias.

  1. “Yo soy del Son a la Salsa”: La re-edición de nuevas expresiones interculturales caribeñas en el espacio cinematográfico

    Directory of Open Access Journals (Sweden)

    Maydi Estrada Bayona

    2014-01-01

    Full Text Available “Yo soy del Son a la Salsa”: La re-edición de nuevasexpresiones interculturales caribeñas en el espacio cinematográfico,es un artículo reflexivo que forma parte dela investigación titulada: Claves Interculturales Caribeñasen la poética cinematográfica de Rigoberto López. El mismoconstituye un acercamiento al tratamiento del temade la diáspora cubana y caribeña en el contexto del Caribeafro-hispánico insular y en Nueva York. El estudio tomacomo antecedente el largometraje de ficción La Últimacena, (1976 de Tomás Gutiérrez Alea y como obra principalel documental: Yo soy del Son a la Salsa, (1996 deRigoberto López, para a través de los aportes de la narrativacinematográfica cubana valorar acerca del impactosociocultural del sujeto migrante en los espacios de acogiday de origen. Ambas obras son referentes en el análisisde estos fenómenos sociales en relación a: su evoluciónen el tiempo, unicidad y diversidad de manifestaciones.Asimismo visualiza la complejidad de las relaciones espacialesabordadas en sus narrativas y explica los nexosentre ellas como obras propiamente. Define la visión interculturale intertextual del documental Yo soy del Son ala Salsa dentro de la estética de la creolización de su creador.Se analiza el lenguaje de la música como expresiónsimbólica de una identidad multicultural caribeña visto, apartir de los géneros musicales del Son y la Salsa, de igualmodo al espacio cinematográfico como revitalizador detradiciones en el Caribe.

  2. Population-based versus hospital-based controls: are they comparable? Controles poblaciones frente a controles hospitalarios: ¿son comparables?

    Directory of Open Access Journals (Sweden)

    Alberto Ruano-Ravina

    2008-12-01

    al día, el riesgo de ser un control hospitalario fue de 4,83 (intervalo de confianza del 95%: 2,55-9,14. Conclusiones: Podría haber algunas diferencias entre los controles poblacionales y los hospitalarios que deberían tenerse en cuenta cuando se diseñe un estudio de casos y controles. Es necesario saber si esas diferencias son similares en otras áreas geográficas y si podrían afectar a la estimación de las medidas de efecto entre exposición y enfermedad.

  3. 《李尔王》中父子冲突的伦理法则%Ethical Rules in the Father-son Conflict in King Lear

    Institute of Scientific and Technical Information of China (English)

    张松林

    2016-01-01

    戏剧《李尔王》中的父子冲突体现了多重伦理原则。首先,父子冲突体现了社会伦理的演变,父权传统遭到了新思想的挑战,子辈中出现了敢于反抗父权的叛逆者,他们不择手段化解父权带来的焦虑和威胁,并最终在冲突中胜出。其次,父子冲突中对自然法则的崇拜破坏了人类社会文明,力量至上的丛林法则让传统道德伦理蒙羞,使其成为不堪一击的社会稳定遮羞布。从美学原则上看,善恶冲突具有使善者价值更为璀璨的作用,文学往往通过恶来衬托善,并通过恶带来的恶果来反思社会伦理的作用。%The father-son conflict in the play King Lear embodies multiple ethical principles .First, the conflict reflects the evolution of social ethics and the traditional patriarchy was challenged by new ideas .The young gen-eration appeared bold enough to rebel against patriarchy .They did anything to resolve anxiety and threats coming from patriarchy and eventually became the winner of the conflict .Secondly , the conflict shows worship for laws of nature which destroyed the civilization of human society .From aesthetic principles , the conflict between good and evil highlights good .So literature tends to zoom good in the background of evil and reflect social ethics through negative consequences brought by evil .

  4. ¿Son las herramientas recomendadas por la ASPEN y la ESPEN equiparables en la valoración del estado nutricional?

    Directory of Open Access Journals (Sweden)

    M.ª A. Valero

    2005-08-01

    Full Text Available Introducción: No existe un método de valoración nutricional universalmente aceptado. Los expertos de ASPEN (2002 sugieren utilizar la valoración subjetiva global (VSG, mientras que los de ESPEN (2002 recomiendan el sistema NRS-2002. Objetivos y ámbito: Este estudio transversal tiene como objetivos: 1 conocer la prevalencia de malnutrición al ingreso hospitalario en un hospital terciario y 2 conocer el grado de asociación entre dos herramientas utilizadas para valorar el estado de nutrición: la VSG y el sistema NRS-2002. Material y métodos: Se estudian 135 pacientes (42,2 % mujeres y 58,8 % varones, edad 62,1 ± 14,5 años en los tres primeros días del ingreso hospitalario, ingresados en camas de Medicina Interna y Cirugía. Se analizan diferentes variables del estado nutricional. Se compara las necesidades calóricas (Harris Benedict x factor de agresión y la ingesta calórica del día anterior al ingreso, mediante recordatorio de 24 horas. Se calcula la prevalencia de malnutrición al ingreso con dos herramientas de screening: VSG y el sistema NRS-2002. Resultados: El 42,2 % de los pacientes reconocen haber perdido peso y el 39,3 % ingieren una dieta inferior a sus necesidades al ingreso en el hospital. Según el método utilizado de valoración nutricional, la prevalencia de malnutrición es del 40,7 y del 45,1/100 pacientes ingresados con el VSG y el NRS-2002, respectivamente. Existe una asociación significativa entre los resultados obtenidos con ambas herramientas (p = 0,000. Los niveles de albúmina sérica y linfocitos totales son inferiores en los pacientes malnutridos. Conclusiones: La prevalencia de malnutrición al ingreso hospitalario es elevada. Existe una asociación estrecha entre los resultados obtenidos con la VSG y el sistema NRS-2002. Aunque en la práctica clínica cualquiera de los dos métodos puede ser utilizado para valorar el estado de nutrición, consideramos que el sistema NRS-2002, aunque más complejo, es

  5. Biodegradation of the french reference nuclear glass SON 68 by Acidithiobacillus thiooxidans : protective effect of the biofilm,U and REE retention

    Science.gov (United States)

    Bachelet, M.; Crovisier, J.; Stille, P.; Boutin, R.; Vuilleumier, S.; Geoffroy, V.

    2008-12-01

    Although underground nuclear waste repositories are not expected to be favourable places for microbial activity, one should not exclude localized action of extremophilic bacteria on some materials involved in the storage concept. Among endogenous or accidentally introduced acidophiles, some are susceptible to lead to a locally drastic decreased in pH with potential consequences on materials corrosion. Experiments were performed with Acidithiobacillus thiooxidans on 100-125 μm french reference nuclear glass SON68 grains in a mineral medium under static conditions during 60 days at 25°C. Growth medium was periodically renewed and analyzed by ICP-AES and ICP-MS spectrometry for both major, traces and ultra-traces elements. Biofilm formation was evidenced by confocal laser microscopy, staining DNA with ethidium bromide and exopolysaccharides with calcofluor white. Biofilm thickness around material grains exceeded 20 μm under the chosen experimental conditions. It can be noticed that while numerous studies on biofilm formation upon interaction between Acidithiobacillus ferrooxidans and materials can be found in the literature, evidence for biofilm formation is still scarce for the case of the acidophilic bacterium A. thiooxidans. Presence of biofilm is a key parameter for material alteration at the solid/solution interface in biotic systems. Indeed, various constitutive elements of materials trapped in the polyanionic polymer of biofilm may also influence the alteration process. In particular, biofilm may reduce the alteration rate of materials by forming a protective barrier at their surface (Aouad et al., 2008). In this study, glass alteration rates, determined using strontium, molybdenum and caesium as tracers, showed that the biofilm has a protective effect against glass alteration. U and REE are efficiently trapped in the biogenic compartment of the system (exopolysaccharides (EPS) + bacterial cells). Biofilm analysis are in progress to determine whether these

  6. PERIODISMO, FICCIÓN Y REALIDAD: A PROPÓSITO DE TODO SON PREGUNTAS, EL OJO DE CERRADURA Y SOMBRAS SOBRE SOMBRAS DE JUAN JOSÉ MILLÁS Journalism, Fiction and Reality in Juan José Millás’ Todo son preguntas, El ojo de la cerradura, and Sombras sobre sombras

    Directory of Open Access Journals (Sweden)

    Teresa González Arce

    2008-07-01

    Full Text Available Durante los veranos de 2004, 2005 y 2006, el escritor español Juan José Millás publicó una serie de artículos que más tarde dieron lugar a tres recopilaciones tituladas Todo son preguntas, El ojo de la cerradura y Sombras sobre sombras. Entendidos, a la vez, como preguntas y respuestas suscitadas por fotografías aparecidas en la prensa, los tres volúmenes dan cuenta de una poética sostenida por una concepción espacial del mundo que, de manera explícita, remite a la imagen platónica de la caverna. El escritor utiliza la ficción literaria como una herramienta de interpretación de la realidad -representada aquí por la serie de fotografías- y, al hacer esto, pone en entredicho los límites entre la verdad y las apariencias. Agregar sombras a un mundo poblado por simulacros, parece decir Millás, es la única forma de entender algo en este galimatías en el que vivimos.In the summers of 2004, 2005 and 2006 the Spanish writer Juan José Millás published a series of articles that later appeared in three volumes titled Todo son preguntas, El ojo de la cerradura and Sombras sobre sombras. His essays are best understood as a meditation about press photos that inspire both questions and answers, expressing a poetics grounded in a spatial conception of the world that explicitly invokes the platonic image of the cave. The writer utilizes literary fiction as a tool to interpret reality -represented here in the series of photos- and, in so doing, problematizes the limits between truth and appearance. It is only by adding shadows to a world replete with simulacra, Millás seems to say, that we can make any sense of the world at all.

  7. Are calcium and fiber beneficial for poorly controlled diabetic patients? ¿Son calcio y fibras beneficiosos para pacientes diabéticos mal controlados?

    Directory of Open Access Journals (Sweden)

    D. A. R. Matos

    2011-04-01

    ños, 75,4% mujeres, IMC 29,0 ± 5,3 kg/m² eran con moderada frecuencia insulino-dependentes (32,5% y también sistemicamiente inflamados (PCR 4,2 ± 3,9 mg/L. La dieta era pobre en calorias (1,365 ± 565 kcal/d pero globalmente acceptable, aún que baja en fibras (15,4 ± 8,6 g/d y muy baja en cálcio (592,4 ± 204,4 mg/d. El cálcio e la fibra de la dieta se correlacionaran con valores lipídicos, pero solo la fibra estuvo asociada a mejor panorama de diabetes (HbA1c, uso de insulina y de hipertensión arterial. Conclusiones: La ingestión de cálcio y fibra estuvieron correlacionadas con importantes marcadores de estado metabólico y riesgo cardiovascular. Estúdios futuros son recomendados con empleo de mayores proporciones de estes ingredientes en forma de dieta o suplementos.

  8. Modification et caractérisation de la surface de fibres de verre pour son insertion postérieure dans des matériaux cimentaires

    Science.gov (United States)

    Bismarck, A.; Ajuriagojeaskoa, E. E.; Springer, J.; Habel, W. R.

    1999-07-01

    Optical fibres are widely used as physical and mechanical sensors in various matrices. Those commercial available fibres are mostly coated with different polymers (e.g. polyimide). The problem of using such coatings is the undefined adhesion and the stress transmission from the matrix material into the fibre as well as the alkaline attack from the cementitious environments onto the glass surface. Therefore the known silanisation process with alkylsilanes for surface modification was studied. To achieve a silane film onto the fibre surface as close as possible a fibre pre-treatment in oxygen plasma was applied. The wetting behaviour of the oxygen plasma treated fibres as well as the silanized fibres were studied using the Wilhelmy-method. The influence of the silane concentration and the time of the pre-treatment on the wetting properties was investigated. By scanning electron microscopy, changes of the surface morphology were detected. Additionally, the mechanical properties of the oxygen plasma treated fibres, and silanized fibres exposed to a highly alkaline pore solution were measured. For selected fibre samples (decoated and untreated as well as silanized fibres) the adhesion to a concrete matrix was studied using the indention test. Les fibres optiques sont de plus en plus utilisées comme capteurs des propriétés physiques et mécaniques de nombreuses matrices. Ces fibres commerciales sont généralement enrobées avec différents polymères (par exemple polyimide). Les problèmes dus à l'enrobage des fibres optiques sont une adhésion et une transmission de charge de la matrice du béton à la fibre non définies. Un autre problème majeur est l'alcalinité du béton et son influence sur la surface de la fibre. Nous avons utilisé le procédé de silanisation. Pour obtenir un film de silane le plus homogène possible sur la surface, les fibres sont pré-traitées par le plasma d?oxygène. Le mouillage de fibres traitées par le plasma d?oxygène, ainsi que

  9. Analysis on Manase Dōson's Clinical Academic Characteristics%曲直濑道三临床学术特点探讨

    Institute of Scientific and Technical Information of China (English)

    马骏; 王育林

    2016-01-01

    从日本汉方历史发展的角度,运用文献分析、综合对比、典型案例剖析等研究方法,概括了日本汉方医学后世派代表性医家曲直濑道三的个人生平,分析了《启迪集》《出证配剂》《云阵夜话》《针灸集要》等其临床代表著作,将曲直濑道三临床以阴阳五行学说为框架,擅长灵活运用经验药方,一贯运用"察证辨治"等学术特点,总结为临机应变、倡导察证辨治,医出正宗、强调经典理论,崇尚朱丹溪、重视气血痰,以及简素方便重视实用性四方面,并分析了曲直濑道三治疗伤寒四日少阳病、肺阴虚咳嗽和肝血虚肝气郁不妊的三个病案,进一步阐释其诊疗思维特色,以期为现今中医学临床实践和传承创新提供借鉴和启示.%From the perspective of historical development of Japanese Kampo,this paper summarized Quzhi Laidaosan ' s ( Manase Dōson ' s ) personal life , a representative practitioner in Gosei-ha school of Japanese Kampo medicine,analyzed the classical works including Qi Di Ji(Keiteki Shu),Chu Zheng Pei Ji(Corre-sponding Formula Based on Pattern ) , Yun Zhen Ye Hua ( Night Talks at Yunzhen ) , and Zhen Jiu Ji Yao (Collections of Acupuncture and Moxibustion),and clearly elaborated his ideas that he set Yin-yang theory and five phase theory as frames. He was expert in using empirical prescriptions and insisted on pattern ob-servation and treatment into four clinical academic features for the first time by literature analysis,compre-hensive comparison and discussion on typical cases. The four features were flexibility and advocation of pattern observation and treatment in clinic,origination from authentic school and stress on classical theory, adoration of Zhu Danxi and emphasis of Qi,blood,and phlegm,simplicity,convenience and practicability. Three medical cases including lesser Yang disease contracted by cold pathogen in the fourth day,cough in lung-yin deficiency,and infertility due to Qi

  10. O sentido do sagrado e os rituais de cura no drama Cloçon son, de Fernando de Macedo = The sense of the sacred and healing rituals in Cloçon son, a drama written by Fernando de Macedo

    Directory of Open Access Journals (Sweden)

    Éboli, Luciana

    2012-01-01

    Full Text Available O presente trabalho analisa o drama Cloçon Son, de Fernando de Macedo, sob a perspectiva da construção dramática e da temática da religiosidade em São Tomé e Príncipe. As crenças e manifestações necessárias fundamentam-se nos ritos e cultos que celebram e exteriorizam as crenças da comunidade e unem homem, destino, cosmos e natureza em diferentes níveis e formas de integração, para, por fim, estabelecer o equilíbrio do indivíduo e de seu grupo. A formação da realidade histórica de um povo ou de uma cultura comporta imagens e símbolos, valores morais e religiosos, organização social e política, visão de mundo e constituição de sentido. Nesse percurso, percebe-se a evolução da perspectiva ontológica para a perspectiva histórica sem que se perca o vínculo com a sacralidade das origens, pois ambos os aspectos se integram na experiência mítica do mundo

  11. Terapia fonológica a partir da estimulação de sons isolados e em conjunto Phonological therapy based on the stimulation of single sounds and groups of sounds

    Directory of Open Access Journals (Sweden)

    Karina Carlesso Pagliarin

    2012-03-01

    Full Text Available OBJETIVO: Verificar se a estimulação de sons em conjunto resulta em maiores mudanças fonológicas do que a estimulação de sons isoladamente e analisar a ocorrência de generalização para dentro de uma classe e para outras classes de sons. MÉTODOS: A amostra foi composta por dez sujeitos com desvio fonológico, com idades entre 4 anos e 8 meses a 7 anos e 3 meses, distribuídos em dois grupos. O Grupo 1 (G1 foi tratado pelo modelo de Oposições Múltiplas e o Grupo 2 (G2 pelo modelo ABAB-Retirada e Provas Múltiplas. O tratamento do G1 constou da estimulação do contraste de vários sons apresentados em conjunto enquanto que o tratamento do G2 envolveu a estimulação de apenas um som-alvo por ciclo de tratamento. Foi analisado o número de sons ausentes e a ocorrência de generalização para dentro de uma classe e para outras classes de sons pré e pós-tratamento. Os dados foram analisados estatisticamente; também foi realizada análise descritiva. RESULTADOS: O G1 adquiriu maior número de sons que o G2; entretanto não houve diferença significativa. Em relação à generalização dentro da classe de sons, o G1 apresentou maiores mudanças, enquanto a generalização para outras classes foi maior para o G2; entretanto, não houve diferença estatística em nenhum desses resultados. CONCLUSÃO: Ambos os métodos favoreceram mudanças no sistema fonológico das crianças estudadas, levando à aquisição de fonemas e a generalizações. Não há diferença entre eles na efetividade do tratamento.PURPOSE: To verify whether the stimulation of groups of sounds results in greater phonological changes than the stimulation of single sounds, and to analyze the occurrence of generalization across and within sound classes. METHODS: The sample comprised ten children with phonological disorders, with ages between 4 years and 8 months and 7 years and 3 months, divided into two groups. Group 1 (G1 was treated by the Multiple Oppositions

  12. A case study: Fish production in the integrated farming system of the Black Thai in Yen Chau district (Son La province) in mountainous North-western Vietnam - current state and potential

    OpenAIRE

    Steinbronn, Silke

    2009-01-01

    Son La province is located in mountainous north-western Vietnam and belongs to the poorest regions of the country. In the valleys of this province, fish farming is one of the major activities among farmers who belong to the ethnic Black Thai minority. Up until now, the aquaculture system practiced here has not been scientifically investigated. There is generally very little data available regarding the aquaculture of resource-poor farmers in Southeast Asia. This lack of information can be par...

  13. When Parents Separate and One Parent ‘Comes Out’ as Lesbian, Gay or Bisexual: Sons and Daughters Engage with the Tension that Occurs When Their Family Unit Changes

    OpenAIRE

    Siobhán C Daly; Pádriag MacNeela; Sarma, Kiran M.

    2015-01-01

    The experiences of Irish sons and daughters born into heterosexually-organised parental partnerships/unions whose parents have separated and one has come out as Lesbian, Gay or Bisexual (LGB) were explored through a grounded theory approach. 15 adult children (over the age of 18 years), who varied in age when their parents separated and one disclosed as LGB, were interviewed. The primary concern that emerged centred on participants having to adjust to their parents' being separated, as oppose...

  14. Evolution in karst massifs: Cryptic diversity among bent-toed geckos along the Truong Son Range with descriptions of three new species and one new country record from Laos.

    Science.gov (United States)

    Luu, Vinh Quang; Bonkowski, Michael; Nguyen, Truong Quang; Le, Minh Duc; Schneider, Nicole; Ngo, Hanh Thi; Ziegler, Thomas

    2016-01-01

    Species designated as 'cryptic' share a similar morphotype, and are often only clearly separable by molecular data. Cyrtodactylus, the most diverse gecko genus of the family Gekkonidae, is a prime example, because many morphologically similar taxa have only recently been identified as new species as a result of available genetic evidence. However, while cryptic diversity of Cyrtodactylus is already well documented on the Vietnamese side of the Truong Son range, only scarce data is available from central Laos. In this study, we address this issue by means of an integrative approach, which employs morphological, molecular, and ecological data to distinguish cryptic species of the Cyrtodacylus phongnhakebangensis species group primarily distributed along the northern Truong Son Range. Our analyses based on 12 selected morphological characters, a partial mitochondrial gene (COI), and five ecological parameters revealed three undescribed cryptic Cyrtodactylus species from Hin Nam No National Protected Area, which are described as Cyrtodactylus calamei sp. nov., Cyrtodactylus hinnamnoensis sp. nov., and Cyrtodactylus sommerladi sp. nov. A fourth discovered Cyrtodactylus population in Hin Nam No proved to be the first country record of C. cryptus for Laos. Our results highlight the importance of applying an integrative approach to resolving the taxonomy of complex and cryptic species groups, and the role of the Truong Son Range in maintaining the high level of biodiversity over time. PMID:27394811

  15. Five-year experience in the Czech Republic with the State Office for Nuclear Safety (SONS). Recommendations for QA system at the Departments of nuclear medicine, instruments, and intended amendments

    International Nuclear Information System (INIS)

    Full text: Introduction. Law No. 18/1997 Coll. which came into force in the Czech Republic in the middle of 1997 requires every department of nuclear medicine (NM) to set up a QA Programme containing a section devoted to quality control of equipment performance. In order to facilitate the implementation of this demand into the practice, the detailed guidelines mentioned in the title was prepared. Contents of the SONS recommendations. The guidebook covers all devices used in nuclear medicine for diagnostics, therapy and radiation protection: radionuclide calibrators, single and multi-detector instruments for the measurements in vitro, SPECT scintillation cameras operated in both planar and tomographic regime, dose and dose rate meters and contamination monitors. As an aid to writing the SONS Recommendations the following international and national recommendations were used: IAEA-TECDOC-602 (1991), NEMA (1994), NCRP (1998), IPSM (1992) and others. Considering the extent of SONS Recommendations a compromise was made among comprehensive and too detailed publications (NEMA, IAEA, IEC) and somewhat simpler ones published in Germany and UK. Also, many years of experience was exploited with the quality control of instruments carried out at the Clinics of NM in Olomouc and other departments in our country. The SONS Recommendations consist of 23 sections devoted to the number of tests such as stability, spatial resolution, sensitivity, uniformity, spatial linearity, etc. Each section is divided into the following items: definition, procedure, calculation and analysis including tolerances of parameters (in several tests), test frequency, remedial measures and commentary. Benefits. Immediately after its publication SONS Recommendations became the effective help for departments of NM because such publication in Czech had not been available before. Benefits derived from it are, as follows: (1) a practical guide to both acceptance and regular performance testing, (2) a guide to

  16. Isotope tracing ({sup 29}Si and {sup 18}O) of the alteration mechanisms of the French glass 'SON68' used for the storage of nuclear waste; Tracage isotopique ({sup 29}Si and {sup 18}O) des mecanismes de l'alteration du verre de confinement des dechets nucleaires: 'SON68'

    Energy Technology Data Exchange (ETDEWEB)

    Valle, N

    2001-07-01

    This study aims to enhance our understanding of the mechanisms of aqueous corrosion of the glasses used for the storage of nuclear waste. Glass samples 'SON68', doped with a different rare earth element (La, Ce or Nd), were altered simultaneously with water enriched in {sup 29}Si and {sup 18}O, throughout a period of 20 months. The aim of such isotope tracing was (i) to follow the 'real' exchanges between glass and solution and (ii) to understand the reactions involving Si-O bonds in the leached layer during alteration. Leachates were analyzed by ICP-MS and -AES, and elemental and isotopic variations in the altered glass layer were measured by ion-probe, using a depth profiling technique. Elemental analyses enabled the distribution of the elements in the two layers of altered glass (phyllosilicates and gel) to be established, and the results reveal a selective partitioning of elements between the two layers. Isotopic analyses of altered layers and leachates allowed phyllosilicates to be distinguished from gel, and suggest two different mechanisms of formation. Whilst phyllosilicates grow on the surface of the glass by a mechanism of precipitation, gel is formed by a succession of hydrolysis / condensation reactions taking place mainly at the gel / pristine glass interface. This gel is formed by the in situ rearrangement of hydrated species, without reaching equilibrium with the solution. Moreover, an experimental technique has been developed enabling one to trace the transport of silicon from the solution into the altered glasses, under an isotopic gradient. Diffusion profiles, obtained by ion-probe, have been modeled and have allowed the determination of the apparent silicon diffusion coefficient (DSi) in gels. Therefore, our experiments have permitted the quantification of the influence of both the alteration conditions (dynamic or static tests) and the solution composition on the value of DSi. (author)

  17. Escolha dos sons-alvo para terapia: análise com enfoque em traços distintivos Choice of target sounds for therapy: analysis focused on distinctive features

    Directory of Open Access Journals (Sweden)

    Marizete Ilha Ceron

    2010-01-01

    Full Text Available Os alvos de tratamento podem dificultar ou facilitar as aquisições no inventário fonológico. Este trabalho tem como objetivo verificar a eficácia da proposta de terapia de Oposições Múltiplas, considerando a escolha dos sons-alvo, e analisar a aquisição de sons no inventário fonológico e os traços distintivos, enfocados a partir dos sons-alvo. O grupo pesquisado constituiu-se de cinco crianças com desvio fonológico, média de idade de 6;1 (anos;meses. Foram realizadas avaliações fonoaudiológicas e complementares. Após as avaliações, os sujeitos foram submetidos à fonoterapia pelo Modelo de Oposições Múltiplas. Depois do tratamento, realizou-se uma reavaliação fonológica, a fim de comparar a evolução terapêutica e a eficácia dos alvos escolhidos para cada sujeito. Compararam-se os inventários fonológicos e o número de traços distintivos alterados pré e pós-terapia em cada sujeito, bem como os traços distintivos enfocados na terapia pelos sons-alvo. Os sujeitos que acrescentaram mais fonemas em seus inventários fonológicos foram os que mais diminuíram o número de traços distintivos alterados. Pode-se concluir que o Modelo de Oposições Múltiplas proporcionou aquisições de fonemas no inventário fonológico, sendo esses relacionados às características dos alvos selecionados para cada sujeito. Os sujeitos cujos sons-alvo contemplavam o trabalho com a maioria dos traços alterados e com sons mais complexos na hierarquia apresentaram maiores aquisições em seus inventários fonológicos.The targets of the treatment can facilitate or difficult acquisitions in the phonological inventory. This study had the aim to verify the effectiveness of the therapy proposed by the Multiple Oppositions Model, taking into consideration the target sounds chosen, as well as to analyze the acquired sounds and the distinctive features, based on the target sounds. The researched group comprised five children with

  18. ¿Cuáles son las innovaciones didácticas que propone la investigación en resolución de problemas de física y qué resultados alcanzan?

    OpenAIRE

    Ceberio, Mikel; Guisasola, Jenaro; Almudí, José Manuel

    2008-01-01

    Durante décadas la investigación en resolución de problemas ha constituido objetivo preferente tanto de psicólogos como de investigadores en enseñanza de las ciencias. En este trabajo analizamos las investigaciones en resolución de problemas atendiendo, fundamentalmente, a la propuesta didáctica que realizan, en relación con la cual surgen algunas cuestiones: ¿cuáles son las innovaciones que se proponen? ¿hasta qué punto se logran sus objetivos de aprendizaje? ¿en qué medida los cambios didác...

  19. Impacte de la síndrome d’apnea del son sobre el metabolisme glucídic i la síndrome metabòlica en l’obesitat mòrbida

    OpenAIRE

    Salord i Olèo, Neus

    2016-01-01

    Hi ha evidència creixent de que la síndrome de apnea-hipopnea del son (SAHS) pot tenir efectes adversos sobre la síndrome metabòlica (SMet), el metabolisme glucídic i el risc cardiovascular. Però no se’n coneixen els mecanismes intermediaris. Múltiples estudis aleatoritzats controlats han demostrat que la pressió positiva contínua a la via aèria (CPAP) millora l’estat de salut del pacient amb SAHS, però pocs d’ells han analitzat els efectes sobre el perfil metabòlic, i els que ...

  20. A Conception on Building the Economic Corridor from Nanning of China to Lang Son, Hanoi, Haiphong and Quang Ninh of Vietnam%建设南宁-谅山-河内-海防-广宁经济走廊构想

    Institute of Scientific and Technical Information of China (English)

    农立夫

    2005-01-01

    Leaders from both China and Vietnam have reached agreements on building“Two Corridors and One Ring”, in which “the Economic Corridor from Nanning of China to Lang Son, Hanoi, Haiphong and Quang Ninh of Vietnam”is one of them.The paper mainly analyzes its favorable conditions, content and significance, suggesting that China and Vietnam cooperate in building projects of top priority and then extend their scope. The paper also suggests ways on how governments, research and e-ducational institutions guarantee the successful construction of the corridor.

  1. “They think you’re lazy,” and Other Messages Black Parents Send Their Black Sons: An Exploration of Critical Race Theory in the Examination of Educational Outcomes for Black Males

    Directory of Open Access Journals (Sweden)

    Rema Reynolds

    2010-05-01

    Full Text Available Parents play an integral role in the social, emotional, physical, and intellectual development of their children. We know that school success has been associated with parents’ involvement and engagement1 practices. Studies have shown that despite socioeconomic disparities, children whose parents are involved perform markedly better than those whose parents are not. Little research has looked exclusively at parent involvement and its effects on the educational outcomes of Black males. A qualitative study conducted with Black parents and their involvement and engagement practices as the focus proved that this relationship warrants scholarly attention using Critical Race Theory as a tool for examination. Parents in this study were involved in their children’s educational processes in ways not always validated or valued by schools. Instead of engaging in conventional forms of involvement such as volunteering in the classroom, parents spent time and resources supplementing their children’s education at home. Subtle acts of racism manifested through microaggressions were detected by parents when interfacing with school officials2 and these exchanges prompted candid conversations with their sons. According to the parents in this study, deliberate messages about racism and educator expectations were often critical supplements for their Black sons in order to ensure educational success.

  2. 乾隆御制釉上彩母子图的文化解读%THE CULTURAL MEANINGS OF WESTERNIZED "MOTHER AND SON" THEME DECORATED ON QIANLING COURT PAINTED ENAMEL PORCELAIN

    Institute of Scientific and Technical Information of China (English)

    王屹; 王莹

    2011-01-01

    在乾隆御制釉上彩出现为数不少的西洋式母子图题材,这类题材在形式上既有强烈的西洋特点,又融入了部分的中国传统文化因素.本文试图通过对这类釉上彩西洋式母子图题材的分析,来解读其背后所隐涵的东西方文化在18世纪的碰撞与融合,尤其是耶稣会士希望通过合儒来达到传播天主教所做出的努力.%During Qianlong reign, there are a number of westernized "mother and son" theme appears on court painted enamel porcelain. Such kind of decorative theme not only shows a strong western style, but also shares some Chinese traditional character. This article mainly focuses on exploring the collision and fusion between eastern and western culture especially the "linking Confucianism" work made by Jesuit missionaries,through analyzing the theme of "mother and son" on court painted enamel porcelain.

  3. El surgimiento de la agrupación HIJOS-La Plata: La discusión por quiénes son las víctimas del terrorismo de Estado

    Directory of Open Access Journals (Sweden)

    Santiago Cueto Rúa

    2010-06-01

    Full Text Available Este trabajo analiza el proceso de formación de HIJOS, organismo de derechos humanos que nuclea principalmente a los HIJOS de las "víctimas del terrorismo de Estado" acaecido en la Argentina durante la última Dictadura militar y el período inmediato anterior. A partir del análisis de las disputas por la membresía del grupo, se indaga cómo HIJOS ha reactualizado una discusión que cruza a todo el movimiento de derechos humanos: ¿quiénes son las víctimas del terrorismo de Estado? A su vez se analiza la ambivalencia que el grupo muestra frente a la noción de "víctima". Por un lado, reconocen que son víctimas y que sus padres lo han sido, y por el otro intentan distanciarse de esa noción por el carácter pasivo y despolitizado que supone

  4. Regulatory Allospecific T Cell Clones Abrogate Chronic Allograft Rejection

    OpenAIRE

    Waaga-Gasser, Ana Maria; Grimm, Martin R.; Lutz, Jens; Lange, Volkmar; Lenhard, Susanne M.; Aviles, Beatriz; Kist-van Holthe, Joana E; Lebedeva, Tatiana; Samsonov, Dimitry; Meyer, Detlef; Hancock, Wayne W.; Heemann, Uwe; Gasser, Martin; Chandraker, Anil

    2009-01-01

    True alloantigen-specific tolerance is the ultimate goal of solid organ transplantation, eliminating the need for long-term immunosuppression. Recent evidence suggests that Th1-derived cytokines are associated with rejection and Th2-derived cytokines with long-term allograft survival, but the roles of these subsets in rejection and tolerance are incompletely understood. Here, we analyzed the functional and regulatory capacities of T cell clones derived from tolerant and rejecting rats (Wistar...

  5. Tumor Regulatory T Cells Potently Abrogate Antitumor Immunity1

    OpenAIRE

    Liu, Zuqiang; Kim, Jin H.; Falo, Louis D.; You, Zhaoyang

    2009-01-01

    Treg from mice bearing a breast tumor were elevated (tumor Treg). In vitro, whereas tumor Treg ability to inhibit tumor-primed CD4+ T cell activity is comparable to Treg from naïve mice (naïve Treg), only tumor Treg suppress naïve CD8+ T cell activation and DC function. Neither tumor Treg nor naïve Treg can suppress antitumor immunity at the effector phase of the immune response induced by adoptively-transferred tumor-primed CD4+ T cells. This is consistent with the observation that, in this ...

  6. Vector transmission of leishmania abrogates vaccine-induced protective immunity.

    Directory of Open Access Journals (Sweden)

    Nathan C Peters

    2009-06-01

    Full Text Available Numerous experimental vaccines have been developed to protect against the cutaneous and visceral forms of leishmaniasis caused by infection with the obligate intracellular protozoan Leishmania, but a human vaccine still does not exist. Remarkably, the efficacy of anti-Leishmania vaccines has never been fully evaluated under experimental conditions following natural vector transmission by infected sand fly bite. The only immunization strategy known to protect humans against natural exposure is "leishmanization," in which viable L. major parasites are intentionally inoculated into a selected site in the skin. We employed mice with healed L. major infections to mimic leishmanization, and found tissue-seeking, cytokine-producing CD4+ T cells specific for Leishmania at the site of challenge by infected sand fly bite within 24 hours, and these mice were highly resistant to sand fly transmitted infection. In contrast, mice vaccinated with a killed vaccine comprised of autoclaved L. major antigen (ALM+CpG oligodeoxynucleotides that protected against needle inoculation of parasites, showed delayed expression of protective immunity and failed to protect against infected sand fly challenge. Two-photon intra-vital microscopy and flow cytometric analysis revealed that sand fly, but not needle challenge, resulted in the maintenance of a localized neutrophilic response at the inoculation site, and removal of neutrophils following vector transmission led to increased parasite-specific immune responses and promoted the efficacy of the killed vaccine. These observations identify the critical immunological factors influencing vaccine efficacy following natural transmission of Leishmania.

  7. Taxonomía, ontología y folksonomía, ¿qué son y qué beneficios u oportunidades presentan para los usuarios de la web?

    Directory of Open Access Journals (Sweden)

    Flor Nancy Díaz Piraquive

    2010-05-01

    Full Text Available Muchas personas, entidades públicas y, en especial, entidades privadas, están tratando de obtener el mayor provecho en la utilización de la infraestructura tecnológica de información y comunicaciones, adquirida no solo como una herramienta para el desarrollo de los procesos y actividades en el desempeño cotidiano de sus labores, sino como una oportunidad para la construcción de conocimiento a través del aprendizaje colaborativo. En este artículo se describe de forma breve cómo temas relacionados con la taxonomía, ontología y folksonomía contribuyen de forma acertada a la generación de nuevo conocimiento. Se considerarán varios elementos como: qué son, quién las utiliza, qué benefi cios tienen y qué oportunidades brindan a los usuarios de la web. Algunas de las consideraciones importantes sobre taxonomías muestran cómo estas pasan de ser la ciencia que trata de los principios, métodos y fines de la clasificación, para convertirse en la tecnología utilizada para la gestión eficaz de información y contenidos, la taxonomía es elemento esencial en la construcción de conocimiento dentro de las organizaciones; sobre las ontologías, se muestra cómo a partir de ellas se pueden definir vocabularios que las entidades computacionales logran entender y especifi car con la suficiente precisión como para permitir diferenciar términos y referenciarlos de manera exacta, facilitando las búsquedas en la web y optimizando los recursos de los usuarios; por último, sobre folksonomías se muestra que son una forma para aprovechar el conocimiento de las personas de manera orgánica y democrática, al ordenar y clasifi car la información que circula por Internet, sobre la base de un ambiente de construcción colaborativo, a través de acuerdos que conducen al logro de un mismo objetivo. Este artículo está dirigido a las personas que se interesan por los temas de actualidad, como lo son las taxonomías, las ontologías y las folksonomías.

  8. Les modes de présence du saumon transgénique AquAdvantage Salmon® dans la tentative de construction de son marché

    OpenAIRE

    Barrey, Sandrine

    2015-01-01

    Cette contribution interroge les modes de présence d’un saumon transgénique (l’AquAdvantage Salmon®) dans la tentative de la construction de son marché aux Etats-Unis. Est-il un objet ? Est-il un objet ordinaire ? Elle montre que celui-ci surgit de façon multiple tout au long des réseaux de relation au sein desquels il est amené à s’insérer. Tour à tout nouvel objet technique, poisson, aliment, produit, et « objet frontière », ces modes de présence instaurent aussi de nouvelles réalités socia...

  9. El Sueño como personaje alegórico en dos autos de Calderón: La siembra del Señor (antes de 1655) y Sueños hay que verdad son (1670)

    OpenAIRE

    Gilbert, Françoise

    2008-01-01

    International audience Este artículo analiza la ambigüedad del personaje alegórico de Sueño en dos autos sacramentales de Calderón, La siembra del señor y Sueños hay que verdad son. En el primero, la figura de Sueño, connotada como 'acto de dormir', se alia con la Culpa para contrarrestar la instauración de la Edad de Gracia. Pero con la muerte de Emanuel y la llegada de la Ley Nueva, el personaje se vuelve la voz anunciadora del advenimiento de la Edad de Gracia. En Sueños hay que verdad ...

  10. Políticas deportivas en Río Grande, Tierra del Fuego : La política deportiva atravesando los diferentes deportes y cómo los deportes son instrumentos de la política

    OpenAIRE

    Paredes, Fernando José

    2009-01-01

    Los deportes que se practican en la ciudad son los tradiciones como básquet, voley, handball, natación, fútbol de salón, entre otros. Tomando como objeto de estudio a el fútbol de salón, deporte más popular y más practicado por los sujetos entre ellos: niños, adolescentes, jóvenes, adultos, podemos decir que tiene surgimiento en la década del 70 en la ciudad, como acontecimiento recreativo que se vivía en Colegio Don Bosco: donde se había techado el gimnasio y los siete días de la semana se o...

  11. Trauma in a loyal chinese son: the corpse's sex & children soldiers from death%一名中国孝子的创伤:尸体的性与地狱中的孩子兵

    Institute of Scientific and Technical Information of China (English)

    施琪嘉

    2001-01-01

    @@ 2000年10月,我有幸受北京医科大学的邀请作为期5天的培训讲课,一些同事参加了当时我们在公开场合下对来自该医学院教学医院的病人--一名9岁男孩的问诊,正如现在一样,我的工作受到了接受过美国精神分析培训的特蕾莎*白女士的帮助. Trauma in a loyal chinese son: the corpse's sex & children soldiers from death

  12. Right Transition of Adopted Sons from Different Clans During the Period of the National Government%南京国民政府时期异姓养子权利之变迁

    Institute of Scientific and Technical Information of China (English)

    张亚飞

    2015-01-01

    南京国民政府在成立伊始通过民法典亲属编确立了近代收养制度,彻底废除了收养制度之一的“立嗣”,不再把收养制度与宗祧承继联系起来,而在法律文本上完成了异姓养子从身份到契约的转变。司法层面,国民政府最高法院通过判决例、解释例补充民法典亲属编有关养子的规定。立法和司法逐渐融合,一改北洋政府时期异姓养子之立法与司法断裂的局面,使得传统固有法中的“乞养”终于在西方私法理念的影响下,变为近代民法意义上的收养制度。%At the beginning of the establishment, the National Government set up the modern adoptive system via the Civil Law of the Republic of China, which abolished heirs adoption and the connection of the adoptive system with the offspring inheritance, thus this established the legal transition of adopted sons from different clans from identity to contract.At the judicial level, The Supreme Court complemented the regulations about adopted sons with cases of judgement and interpretations.The gradual integration of legislation and judicial practice changed traditional beggar-supporting practice into the adoptive system in a sense of the civil law.

  13. IGBP: Crown jewel or prodigal son?

    Science.gov (United States)

    Roederer, Juan G.

    At its 1986 General Assembly in Bern, Switzerland, the International Council of Scientific Unions (ICSU) launched what promises to be the biggest and most ambitious enterprise of international scientific cooperation (see “ICSU Gives Green Light to IGBP,” Eos, 67, p. 777, 1986). The International Geosphere-Biosphere Program (IGBP), known also as “Global Change,” has as its main objective to describe and understand the interactive physical, chemical and biological processes that regulate the total Earth system, the unique environment that it provides for life, the changes that are occurring in this system, and the manner in which they are influenced by human actions.It should be no wonder, then, that this year's ICSU General Committee Meeting at the Academia das Ciencias de Lisboa (Lisbon, Portugal, October 11-14) was virtually dominated by IGBP matters, even during the discussion of agenda items that did not include this subject explicitly. It is fair to say that the Unions are just becoming fully aware of the real magnitude of the program they themselves helped launch in Bern in 1986—and of how little input and control they have had so far in its development. An indication of this “awakening” was already apparent during the ICSU General Assembly in Beijing in 1988, but the full realization of the enormous impact and ramifications of IGBP inside and outside ICSU is emerging only now.

  14. Nicolas Sarkozy a recu son homologue estonien

    Index Scriptorium Estoniae

    2008-01-01

    Prantsusmaa president Nicolas Sarkozy pakkus 7. aprillil 2008 Elysée palees kohtumisel president Toomas Hendrik Ilvesega Eestile Prantsusmaa abi tuumaenergeetika küsimustes. Vabariigi President töövisiidil Pariisis 6.-8.04.2008

  15. Brady, Our Firstborn Son, Has Autism

    Science.gov (United States)

    Yeh-Kennedy, Mei

    2008-01-01

    Autism awareness is spreading like wildfire. Diagnoses have increased at an astounding rate. The statistic most often quoted is that 1 child in 150 has autism. As if the high rate of autism diagnoses were not worrisome enough, many doctors are not properly trained, or kept up to date, on how to detect autism at the earliest possible age. In many…

  16. SONS Of Heavenly God"

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Having seen a number of the Hani terraced fields in 2001,Professor Xie Ninggao,director of the World Heritage Center at Beijing University and advisor on sceic spots and places of interest to the Ministry of Construction.Looked Puzzled.

  17. Leptotrachelus dorsalis: the prodigal son returns

    Science.gov (United States)

    Insecticides are well established as a production practice that can de-stabilize agricultural ecosystems. This occurs because insecticides frequently control not only the pest, but they also kill beneficial insects. These beneficial insects help to maintain the pests bellow economic levels and if th...

  18. ¿Qué son las instituciones?

    Directory of Open Access Journals (Sweden)

    Geoffrey Martin Hodgson

    2011-07-01

    Full Text Available Aunque el término institución tiene una larga historia en las ciencias sociales, aún no existe consenso en torno a su definición. El autor primero muestra las ambigüedades que presentan los planteamientos de North al limitar el concepto de institución a los sistemas de reglas formales que rigen a las organizaciones. Luego, para superar estas dificultades, propone un concepto más amplio que tiene en cuenta la base informal de todo comportamiento estructurado y duradero.

  19. The Right Son at the Right Time

    Institute of Scientific and Technical Information of China (English)

    崔礼山

    2004-01-01

    The story began on a downtown Brooklyn street corner.An elderly man had collapsed while crossing the street.and an ambulance rushed him to Kings County Hospital.There.when he came to now and again.the man repeatedly called for his son.

  20. MAPAS COGNITIVOS. QUE SON. COMO EXPLORARLOS.

    Directory of Open Access Journals (Sweden)

    Constancio De Castro Aguirre

    1999-12-01

    Full Text Available Durante estos últimos años se maneja una terminología que en su multiplicidad de formas encubre una gran ambigüedad. Así sucede por ejemplo, cuando se habla de mapas mentales, mapas cognitivos, imágenes mentales etc. La imaginería mental cultivada con ardor entre los psicólogos nos ha prestado una óptica a los geógrafos. Este trabajo pretende realizar un trabajo de precisión que aquilate los términos y los conceptos. Concretamente busca abrir un camino de rigor conceptual a los mapas cognitivos.

  1. ¿Qué son las instituciones?

    OpenAIRE

    Geoffrey Martin Hodgson

    2011-01-01

    Aunque el término institución tiene una larga historia en las ciencias sociales, aún no existe consenso en torno a su definición. El autor primero muestra las ambigüedades que presentan los planteamientos de North al limitar el concepto de institución a los sistemas de reglas formales que rigen a las organizaciones. Luego, para superar estas dificultades, propone un concepto más amplio que tiene en cuenta la base informal de todo comportamiento estructurado y duradero.

  2. André Gide et son Journal

    NARCIS (Netherlands)

    Albarda, Maria

    1942-01-01

    Nous croyons pouvoir dire, en terminant, gue c'est la musique, et Ia musique seule, qui a influencé Gide sans aucune interruption. Ses conceptions musicales n'ont pas varié. Il ne s'agit pas de considérations vagues sur les rapports de la musique et de la littérature: c'est la musique prise en soi q

  3. MAPAS COGNITIVOS. QUE SON. COMO EXPLORARLOS.

    OpenAIRE

    Constancio De Castro Aguirre

    1999-01-01

    Durante estos últimos años se maneja una terminología que en su multiplicidad de formas encubre una gran ambigüedad. Así sucede por ejemplo, cuando se habla de mapas mentales, mapas cognitivos, imágenes mentales etc. La imaginería mental cultivada con ardor entre los psicólogos nos ha prestado una óptica a los geógrafos. Este trabajo pretende realizar un trabajo de precisión que aquilate los términos y los conceptos. Concretamente busca abrir un camino de rigor conceptual a los mapas cognitiv...

  4. The Strengths of My Son, Trayvon Martin

    Science.gov (United States)

    Ponds, Kenneth

    2013-01-01

    For over 30 years, Ken Ponds has served as Chaplain to thousands of children of color at Starr Commonwealth. This school was founded in 1913 by Floyd Starr with the legendary motto "There is no such thing as a bad boy." Starr Commmonwealth sees their mission as "discovering greatness" in every young person. In this interview…

  5. Sons, Daughters, and Intergenerational Social Support.

    Science.gov (United States)

    Spitze, Glenna; Logan, John

    1990-01-01

    Examined effects of the number and gender composition of children on the receipt of social support by older persons. Effects varied with type of support: having daughters was most salient for telephone contact, while frequency of visiting was affected by both gender and number of children. (Author/TE)

  6. TYPE SON DAM BI孙丹菲

    Institute of Scientific and Technical Information of China (English)

    苏柚

    2009-01-01

    24岁,因为KRUMPING舞成为韩国的“女版Rain”。25岁,跳着椅子舞的她嘴里唱着“疯了”。26岁,她把“星期六晚上”变成了年轻人口中的通关密语。这个人就叫孙丹菲。

  7. Comment attirer une entreprise sur son territoire?

    Directory of Open Access Journals (Sweden)

    Jean René MOREAU

    2002-06-01

    Full Text Available The development of the local communities is very closely related to the economic environment; local public managers have to be able to establish a coherent strategy for creating valuable partnerships with the private firms.

  8. How general are current comparative physiology studies?: A quantitative review ¿Cuán general son los estudios en fisiología comparada actualmente?: Una revisión cuantitativa

    Directory of Open Access Journals (Sweden)

    ROBERTO F. NESPOLO

    2005-06-01

    ómicas, las cuales representan un tercio de los phyla animales existentes. La caracterización no taxonómica de los animales (endotermia/ectotermia, acuático/terrestre, sin embargo, produjo un panorama más equilibrado. Además, los resultados sugieren que los ecólogos fisiológicos son eminentemente biólogos intraespecíficos pues la gran mayoría de los trabajos fueron estudios de una especie. Los estudios multiespecíficos son minoritarios y comparables en proporción a estudios comparativos entre dos especies. Estos últimos, a pesar de haber sido fuertemente criticados en el pasado, siguen siendo publicados. El análisis de tablas de contigencia sugiere que poblaciones naturales y vertebrados son preferidos por sobre poblaciones artificiales, invertebrados y animales acuáticos. Aunque reconocemos las limitaciones de esta revisión, el presente trabajo sugiere que los sesgos históricos deben considerarse cuando se están originando enfoques más globales dentro de la disciplina

  9. Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

    DEFF Research Database (Denmark)

    Rasmussen, Kasper D; Jia, Guangshuai; Johansen, Jens V;

    2015-01-01

    DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to...... protect CG dinucleotide (CpG) islands and promoters from aberrant DNA methylation. In this study, we present a novel Tet2-dependent leukemia mouse model that closely recapitulates gene expression profiles and hallmarks of human AML1-ETO-induced AML. Using this model, we show that the primary effect of Tet......2 loss in preleukemic hematopoietic cells is progressive and widespread DNA hypermethylation affecting up to 25% of active enhancer elements. In contrast, CpG island and promoter methylation does not change in a Tet2-dependent manner but increases relative to population doublings. We confirmed this...

  10. Value of interphase fluorescence in situ hybridization in diagnosing acute myeloid leukemia M2 and M3%间期荧光原位杂交技术在急性髓系白血病M2和M3型诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    许民; 周永安; 赵瑾; 杜苏萌; 吴坚锐

    2008-01-01

    目的 探讨间期荧光原位杂交技术(FISH)在急性髓系白血病(AML)M2和M3诊断中的意义.方法 对初治的9例AML-M3、12例AML-M3及10例未能确定M2或M3的AML患者,应用FISH和反转录-聚合酶链反应(RT-PCR)检测AMLI/ETO和PML/RARα融合基因,协助诊断和指导治疗.结果 9例AML-M2中AMLI/ETO融合基因阳性率44.4%(4/9);12例AML-M3中PML/RARα融合基因阳性率83.3%(10/12),其中1例AML1/ETO融合基因阳性.确诊为AML-M2;10例AML中AML1/ETO融合基因阳性率30%(3/10),PML/RAR Ot融合基因阳性率50%(5/10),其余2例未检测到以上两种融合基因.结论 FISH是一种敏感、简便的分子遗传学新技术,具有高效、快速、灵敏等优点,对诊断AML的分型具有重要帮助,可进一步指导临床治疗.%Objective To investigate the value of interphase fluorescence in situ hybridization(FISH)technique and the detection of fusion gene in the diagnosis of acute myeloid leukemia(AML)M2 and M3 Methods FISH was used to detect the AML1/ETO fusion gene and/or PML/RARα fusion gene in incipient cases including 9 AML-M2, 12 AML-M3 and 10 AML undetermined as AML-M2 or AML-M3 primarily diagnosed by routine morphology though bone marrow,cytochemical staining and immunophenotyping,which can help diagnose and guide clinical therapy.Results 4 of 9 AML-M2 cases were AML1/ETO positive.Among 12 AML-M3 cases,10 were PML/RARα positive.1 case was detected AML1/ETO fusion gene.In 10 untonfirmed M3 or M2,3 case8 showed AML1/ETO,5 showed PMIJRARot fusion gene and the rest showed neither of the genes.Conclusion As a new technique of the molecular genetics,FISH is accurate, rapid and efficient.It would be of significance not only at diagnosis of AML,but also for subsequent clinical decision-making.

  11. Las nuevas guías de hipertensión arterial y dislipidemia, más allá de la controversia, ¿son guías confiables?: beyond the controversy, are they reliable guides?

    Directory of Open Access Journals (Sweden)

    Sergio Vásquez-Kunze

    2014-03-01

    Full Text Available Recientemente se han publicado en el “Octavo reporte del Joint National Commitee”; la “Guía de hipertensión arterial” y la “Guía de manejo de dislipidemia”. Ambas son basadas en la evidencia y han guiado sus recomendaciones exclusivamente en resultados de ensayos clínicos, dejando de lado, en lo posible, recomendaciones formuladas por expertos. Ambas han introducido cambios metodológicos importantes, en la forma de catalogación y al resumir la evidencia utilizada. La “Guía de hipertensión arterial” ha sido realizada para hacer de ella una guía confiable, tiene como característica resaltante la simplificación de recomendaciones y, la guía misma, es un documento simple, de fácil implementación. Un cambio potencialmente interesante en la guía de dislipidemia constituye el abandono de la meta terapéutica numérica para emplear la modificación del nivel de riesgo, que podría promover una discusión sobre la intensidad del tratamiento, tomando en cuenta las preferencias, y así impulsarr la toma de una decisión compartida

  12. Las nuevas guías de hipertensión arterial y dislipidemia, más allá de la controversia, ¿son guías confiables?: beyond the controversy, are they reliable guides?

    Directory of Open Access Journals (Sweden)

    Sergio Vásquez-Kunze

    2014-01-01

    Full Text Available Recientemente se han publicado en el “Octavo reporte del Joint National Commitee”; la “Guía de hipertensión arterial” y la “Guía de manejo de dislipidemia”. Ambas son basadas en la evidencia y han guiado sus recomendaciones exclusivamente en resultados de ensayos clínicos, dejando de lado, en lo posible, recomendaciones formuladas por expertos. Ambas han introducido cambios metodológicos importantes, en la forma de catalogación y al resumir la evidencia utilizada. La “Guía de hipertensión arterial” ha sido realizada para hacer de ella una guía confiable, tiene como característica resaltante la simplificación de recomendaciones y, la guía misma, es un documento simple, de fácil implementación. Un cambio potencialmente interesante en la guía de dislipidemia constituye el abandono de la meta terapéutica numérica para emplear la modificación del nivel de riesgo, que podría promover una discusión sobre la intensidad del tratamiento, tomando en cuenta las preferencias, y así impulsarr la toma de una decisión compartida

  13. ¿Son los clubes de fútbol eficientes? Aplicación del análisis DEA a los equipos de la liga profesional de fútbol de España

    Directory of Open Access Journals (Sweden)

    Carlos Giner Vicente

    2008-01-01

    Full Text Available El objeto del trabajo es analizar la eficiencia de los clubes de fútbol de la primera división de España. Para ello se ha utilizado como muestra de medida el Análisis Envolvente de Datos (DEA, técnica no paramétrica de análisis, que incorpora dos outputs y cuatro inputs. Presenta como novedad que los datos utilizados son económicos y no técnicos. Los datos obtenidos nos indican que sólo hay dos empresas eficientes y que el resto de empresas si quieren ser eficientes necesitan conseguir, obligatoriamente, éxitos deportivos que acompañen lo mismo en la gestión económica. También hemos obtenido datos que indican que la mayoría de las empresas analizadas podrían disminuir la cantidad de inputs utilizados, especialmente gastos de personal y amortización, sin que su output final (clasificación se viera afectado.

  14. Avaliação do processamento auditivo de sons não-verbais em indivíduos com doença de Parkinson Auditory processing evaluation using nonverbal sounds in subjects with Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Eliana S. Miranda

    2004-08-01

    Full Text Available Entendemos que o processamento auditivo é o processo de como o indivíduo gerencia as informações recebidas auditivamente. É reconhecida a importância da percepção auditiva de seqüências e padrões temporais de sons na aquisição e compreensão dos componentes simbólicos da linguagem, sendo que as propriedades acústicas da fala poderiam ser reduzidas aos componentes básicos de duração e freqüência. Entre os eventos que percebemos por meio da audição, a fala é o mais importante, sendo que esta pode apresentar-se alterada na Doença de Parkinson. OBJETIVO: Avaliar o desempenho de portadores de doença de Parkinson nos Testes de Padrão de Freqüência e de Duração. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Avaliou-se a identificação de estímulos sonoros não-verbais, por meio de três tipos de respostas: humming, nomeação e apontar. Os estímulos eram constituídos por dez seqüências de três e quatro sons, variando em freqüência e duração. RESULTADOS: Mostraram-se que não houve diferença quanto ao tipo de resposta; houve um melhor desempenho utilizando o parâmetro três estímulos em oposição a quatro e o aspecto da duração em oposição ao de freqüência. Ressalta-se ainda que o desempenho da população avaliada foi inferior aos indivíduos normais. CONCLUSÃO: A capacidade de ordenação temporal de sons é uma importante função do sistema auditivo nervoso central. Essa habilidade permite que o ouvinte faça discriminações baseadas na ordenação ou seqüenciação de estímulos auditivos. Sendo assim, a contribuição desse estudo é significativa, uma vez que inicia a reflexão do processo de análise e interpretação de sons pelos indivíduos com doença de Parkinson.Auditory processing, as we understand, refers to how the individual handles with auditory information. The importance of auditory perception of sound sequences and temporal patterns in acquiring and comprehending

  15. Kidney transplantation from a mother with unrecognized Fabry disease to her son with low α-galactosidase A activity: A 14-year follow-up without enzyme replacement therapy.

    Science.gov (United States)

    Odani, Keiko; Okumi, Masayoshi; Honda, Kazuho; Ishida, Hideki; Tanabe, Kazunari

    2016-07-01

    We report a case of kidney transplantation from mother to son, both of whom were likely to have had an unrecognized renal variant phenotype of Fabry disease. The patient was a 54-year-old man, with an unknown primary cause of end stage renal disease. He had no notable past medical history, other than end stage renal disease. He underwent living-related kidney transplantation from his mother at age 40 years. Foam cells in the glomeruli were identified on histology assessment of a 0-hour allograft biopsy, with zebra bodies identified in the glomerular visceral epithelial cells by electron microscopy. These findings were indicative of Fabry disease in the donated kidney. As a definitive diagnosis of Fabry's disease could not be confirmed, enzyme replacement therapy was not initiated. Thirteen years after kidney transplantation, the patient underwent left nephrectomy for a left renal tumour, with pathological findings of clear cell carcinoma, foam cells and zebra bodies in the native kidney. Detailed examinations identified low α-galactosidase A activity and mutation of the α-Gal A gene, confirming a diagnosis of a renal variant phenotype of Fabry disease. Histology of several allograft biopsies performed over the 14 years from the time of kidney transplantation revealed only moderate interstitial fibrosis and tubular atrophy, with no evidence of disease progression on electron microscopy, despite the presence of zebra bodies in the glomerular visceral epithelial cells. PMID:26971403

  16. Crisis de representación y de participación. ¿son las comunidades virtuales nuevas formas de agregación y participación ciudadana?

    Directory of Open Access Journals (Sweden)

    Fuster Morell, Mayo

    2012-08-01

    Full Text Available Democratic political systems are currently undergoing something of an upheaval. Based on an analysis of two case studies concerning Online Creation Communities (OCCs, which are conceived of and implemented on the Internet, this paper presents some conclusions regarding the specific characteristics of the participation and the political agency that have the potential to become more widespread as the profound transformation of contemporary democracy proceeds. The cases studied are the project of memory viva of the European Social Forum and Wikipedia.

    Los sistemas políticos democráticos están atravesando un período de fuertes convulsiones. A partir del análisis de dos casos de estudio de Comunidades de Creación Online (CCOs, como formas pensadas e implementadas en y desde Internet, el artículo presenta algunas conclusiones sobre las características específicas de la participación y la agencia política que puedan resultar generalizables en un proceso de transformación profunda de la democracia contemporánea. Los casos de estudio son el proyecto de memoria viva del Foro Social Europeo y Wikipedia.

  17. On FU Lei's Music Educational Thoughts A Perspective of FU Lei's Letters to His Sons%从《傅雷家书》看傅雷音乐教育思想

    Institute of Scientific and Technical Information of China (English)

    袁茵

    2012-01-01

    FU Lei not only had great attainments of music theories but successful experience in music education. His work FULei's Letters to His Sons has reflected how he cultivated FU Cong into a world class pianist and a pianist poet. His educational conceptions in music lie in the view "learning first to be a person and then to be a pianist", emphasis on the cultivation of deep and internal culture, formation of careful and down-to-earth study attitude and continuous innovation. His educa tional thoughts in music have exerted great influence on the contemporary music education.%傅雷不仅具有精湛的音乐理论造诣,而且有音乐教育方面的成功经验。《傅雷家书》即折射出傅雷如何培养、教育傅聪成为世界级的钢琴大师、"钢琴诗人"的成功教育理念。傅雷的音乐教育理念体现为:先为人、次为艺术家;重视文化底蕴培养;认真踏实的学习态度培养;不断创新求发展。傅雷音乐教育思想对当代音乐教育有重要影响。

  18. Comparative Analysis of Different Approaches to Measure Treatment Response in Acute Myeloid Leukemia

    Science.gov (United States)

    Inaba, Hiroto; Coustan-Smith, Elaine; Cao, Xueyuan; Pounds, Stanley B.; Shurtleff, Sheila A.; Wang, Kathleen Y.; Raimondi, Susana C.; Onciu, Mihaela; Jacobsen, Jeffrey; Ribeiro, Raul C.; Dahl, Gary V.; Bowman, W. Paul; Taub, Jeffrey W.; Degar, Barbara; Leung, Wing; Downing, James R.; Pui, Ching-Hon; Rubnitz, Jeffrey E.; Campana, Dario

    2012-01-01

    Purpose In acute myeloid leukemia (AML), initial treatment response by morphologic analysis of bone marrow predicts long-term outcome. Response can now be assessed by minimal residual disease (MRD) monitoring with flow cytometry or polymerase chain reaction (PCR). We determined the relation among the results of these approaches and their prognostic value. Patients and Methods In the multicenter AML02 study, follow-up bone marrow samples from 203 children and adolescents with newly diagnosed AML were examined by flow cytometry (n = 1,514), morphology (n = 1,382), and PCR amplification of fusion transcripts (n = 508). Results were correlated with treatment outcome. Results Among 1,215 samples with less than 5% leukemic myeloblasts by morphology, 100 (8.2%) were MRD positive (≥ 0.1%) by flow cytometry, whereas 96 (57.5%) of the 167 samples with ≥ 5% blasts were MRD negative. Virtually all (308 of 311; 99.0%) MRD-negative samples by PCR were also MRD negative by flow cytometry. However, only 19 (9.6%) of the 197 PCR-positive samples were flow cytometry positive, with analyses of AML1-ETO and CBFβ-MYH11 accounting for most discrepancies, whereas eight of 13 MLL-positive samples had detectable MRD by flow cytometry. MRD by flow cytometry after induction 1 or 2 predicted lower event-free survival and higher relapse rate (P < .001) and was an independent prognostic factor in a multivariable analysis; prediction was not improved by morphologic information or molecular findings. Conclusion In childhood AML, morphologic assessment of treatment response has limited value if MRD is measured by flow cytometry. MLL fusion transcripts can provide prognostic information in some patients, whereas monitoring of AML1-ETO and CBFβ-MYH11 transcripts is largely uninformative. PMID:22965955

  19. Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors

    Directory of Open Access Journals (Sweden)

    Zhang Z

    2013-06-01

    Full Text Available Zhihua Zhang,1 Changlai Hao,1 Lihong Wang,1 Peng Liu,2 Lei Zhao,1 Cuimin Zhu,1 Xia Tian31Hematology Department, Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, 2Department of Medical Oncology, Shijiazhuang Municipal No 1 Hospital, Hebei Province, 3Department of Medical Oncology, Rizhao Municipal People’s Hospital, Shandong Province, People's Republic of ChinaAbstract: The chimeric fusion protein, AML1-ETO, generated by translocation of t(8;21, abnormally recruits histone deacetylase (HDAC to the promoters of AML1 target genes, resulting in transcriptional repression of the target genes and development of t(8;21 acute myeloid leukemia. Abnormal expression of cyclin-dependent kinase inhibitors, especially p21, is considered a possible mechanism of the arrested maturation and differentiation seen in leukemia cells. A new generation of HDAC inhibitors is becoming an increasing focus of attention for their ability to induce differentiation and apoptosis in tumor cells and to block the cell cycle. Our previous research had demonstrated that valproic acid induces G0/G1 arrest of Kasumi-1 cells in t(8;21 acute myeloid leukemia. In this study, we further confirmed that valproic acid inhibits the growth of Kasumi-1 cells in a murine xenograft tumor model, and that this occurs via upregulation of histone acetylation in the p21 promoter region, enhancement of p21 expression, suppression of phosphorylation of retinoblastoma protein, blocking of transcription activated by E2F, and induction of G0/G1 arrest.Keywords: valproic acid, acute myeloid leukemia, AML1-ETO, p21, E2F

  20. Cúales son los síntomas menopáusicos más prevalentes en mujeres de tres comunidades étnicas de la costa Caribe colombiana?

    Directory of Open Access Journals (Sweden)

    Vásquez -Medrano Saret

    2011-09-01

    Full Text Available INTRODUCCIÓN: evaluar con “Menopause Rating Scale” la frecuencia y severidad de síntomas menopáusicos presentes en mujeressaludables de 40-59 años de edad que son originarias y residen en distintas comunidades del Caribe colombiano.MATERIALES Y MÉTODOS: estudio cross-sectional. Con instrumentos aplicados entre noviembre del 2006 y enero del 2009 a mujeressaludables entre 40 y 59 años de edad, tomadas de comunidades afrodescendientes (San Cayetano, Bolívar, indígenas (San Andrésde Sotavento, Córdoba e hispánicas (Cartagena, Bolívar todas de la costa Caribe colombiana. Se aplicó la escala de calidad de vida“Menopause Rating Scale” en su versión en lengua española. Se llenaron 1257 formularios, de los cuales se eliminaron 42 (3.3% porestar incompletos. 1215 mujeres caribeñas colombianas están incluidas en la presente evaluación. El análisis fue realizado con SPSS15.0. Los datos se expresan en medias con desviación estándar y en porcentajes. Se realizaron análisis no paramétricos para evaluardeferencias debido a la falta de normalidad de los datos. Una P<0,05 fue considerada significativa. Se obtuvo consentimientoinformado por parte de las participantes.RESULTADOS: 1215 mujeres caribeñas colombianas se incluyeron en la evaluación, que hacen parte de un grupo mayor queconforman el estudio CAVIMEC (Calidad de Vida en la Menopausia y Etnias Colombianas. 36.5% indígenas Zenúes, 32.4% afrodescendientes y 31.0% hispánicas. Edad promedio: 49.7 +/- 5.9 años, escolaridad promedio: 4.9 +/- 4.0 años, nunca fumadoras: 783(64.4%. En posmenopausia: 579 (47.7% y edad promedio de menopausia: 49.0 +/- 2.8. Los síntomas menopáusicos en orden defrecuencia manifestados por las mujeres involucradas fueron: dolores musculares y articulares: 72.9%, sofocos, sudoración, oleadasde calor: 70.4%, cansancio físico y mental: 68.8% e irritabilidad: 62.0%. Los problemas de vejiga, sequedad vaginal y sexuales fueronreportados por el 47

  1. Quelles aides les formations hybrides en langues proposent-elles à l'apprenant pour favoriser son autonomie ? What kind of assistance do blended language learning courses provide to learners in order to foster their autonomy?

    Directory of Open Access Journals (Sweden)

    Elke Nissen

    2007-11-01

    Full Text Available L'apprenant qui suit une formation hybride en langues travaille partiellement à distance, ce qui lui demande une certaine autonomie. La question alors est de savoir si ces formations soutiennent l'apprenant dans le développement de son autonomie et si oui, comment. Les réponses des concepteurs de huit formations hybrides à un questionnaire auto-administré montrent que les nécessaires développement et soutien de l'autonomie sont toujours respectés ; ainsi, ces huit formations proposent des aides pour favoriser l'autonomie dans les domaines technique, méthodologique, social et, bien sûr, langagier. Développer ces autonomies semble donc être devenu un standard dans le cadre des formations observées. En revanche, les autonomies de type psycho-affectif, informationnel, cognitif et métacognitif ne sont pas prises en considération dans toutes les formations.When taking a blended learning course, a learner works partially at a distance, which requires some autonomy. The aim of this study is to find out whether blended learning courses sustain the development of learner autonomy and if they do so, how they do it. The statements that 8 course designers made in a questionnaire show that their courses always help the learners to become or to be autonomous. All 8 courses provide assistance (advice, information and activities in order to foster technical, methodological, social and, of course, language autonomy. Consequently, sustaining these four types of autonomy seems to have become a standard in blended learning courses. But, on the contrary, assistance for other types of autonomy is not systematically provided: only several of these courses help the learners to develop psycho affective, informational, cognitive and metacognive autonomy.

  2. 对二女争子故事起源和演变之推测%Speculation on Origin and Evolvement of Stories about Two Women Scrambling for a Boy as Their Own Son

    Institute of Scientific and Technical Information of China (English)

    芦笛

    2011-01-01

    对中国古籍中涉及二女争子类型的故事加以比较和考索,推测其极有可能源于印度佛经和西方《圣经》中的相关故事。这些故事在中国流传的过程中,往往被加入本土化的因素,因此得以流传甚广,而且有窜入正史的可能。同时,以二女争子故事为创作原型的元杂剧《包待制智赚灰阑记》在中国清朝末期之后还屡为欧洲学者或作家所介译或改编,由此也可令人感受到世界在文化上的相互融合和发展过程。%With the comparison of and textual research on the different stories about two women scrambling for a boy as their own son,which are recorded in Chinese ancient works,this paper argues that the stories were probably derived from correlative ones in Indian sutra and the Bible.Some local factors are often added into the stories when they gradually spread in China,as a result of which they become widespread and get the possibility of entering official historical works.Meanwhile,the drama The Chalk Circle,which was written in the Yuan dynasty,has taken the prototype from the story.It has been translated or adapted by European scholars and writers repeatedly since the end of the Qing Dynasty,from which people can sense the fusion and development of world cultures.

  3. 别格的身份构建--《土生子》的存在主义解读%The Identity Construction of Bigger-Existential Analysis of Native Son

    Institute of Scientific and Technical Information of China (English)

    桑丹

    2015-01-01

    存在主义产生于20世纪的二十年代,是探讨人的生存状态的哲学,而基于此又产生了存在主义文学。存在主义文学延续了存在主义的基本思想,描绘了世界的荒谬及人生的痛苦。而存在主义的大师——萨特,更是对存在主义进行了系统地论述。他的存在主义观点为解读理查德·赖特的《土生子》提供了新的视角,而分别从自我、他人和责任三个方面来构建别格的黑人身份,可以展现出一个不同的新黑人形象,深化对《土生子》的认识。%Existentialism, emerging in 1920s, is a philosophy, which talks about the living state of human being. And based on it, existential literature came into being. The existential literature has kept the basic ideas of existentialism, which describes the absur⁃dity of the world and the sorrow of its people. Sartre, the master of existentialism, had once made a systematic study of it. Based on the ideas of Sartre, the novel Native Son can be interpreted from three aspects:self, the other and responsibility, through which a new image of the black is constructed and a deeper comprehension about the novel is achieved.

  4. Research on "Author's Presence"in The Heroic Sons and Daughters of a Manchurian Family%论《儿女英雄传》中“作者现身”方式

    Institute of Scientific and Technical Information of China (English)

    高永东

    2011-01-01

    The Heroic Sons and Daughters of a Manchurian Family shows excellent narrative skills, part of which is "authorrs presence", which is contrary to the general rule of "the author's retreat" that is characteristic of novels as a developed genre. "Author's presence"mainly consists of such parts as follows.the storyteller that indicates the author;the characters who comment on the author and the novel itself. This skill is similar to that of metafictional novels in the postmodern literature, but in the former,repeated "author's presence" is just the emotional outbursts of the author, which aims to win the readerstapproval,while in the latter, "author/s presence" implies the deconstruction of the author~ s authority on the contray.%《儿女英雄传》的叙述技巧非常出色。其最特别的,是文本中作者频频现身。这种“作者现身”有违小说发展为一个成熟文体之后“作者隐退”的一般规律,主要表现为“说书人”对作者的指涉以及书中人物对作者及小说本身的评论。这一技巧神似后现代文学中的“元小说”。但是,小说中一次次的“作者现身”,只不过是作者个人情绪的一种宣泄,意在赢得读者对作者的认同;元小说恰恰相反,它是要解构作者权威的。

  5. Un Etat membre peut imposer les plus-values latentes d’une société au moment de son transfert de siège sans entraver la liberté d’établissement [CJUE 29 nov. 2011, National Grid Indus, C-371/10

    OpenAIRE

    Sibony, Anne-Lise

    2012-01-01

    Un Etat membre peut imposer les plus-values latentes d’une société au moment de son transfert de siège sans entraver la liberté d’établissement [CJUE 29 nov. 2011, National Grid Indus, C-371/10

  6. 6 November 2013 - Permanent Representative of Chile to the United Nations Office and Other international organizations in Geneva Ambassador J. Balmaceda Serigos signing the guest book with Adviser for Latin America J. Salicio Diez; visiting the ATLAS experimental cavern with Spokesperson D. Charlton (Spouse, Son and First Secretary present).

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    6 November 2013 - Permanent Representative of Chile to the United Nations Office and Other international organizations in Geneva Ambassador J. Balmaceda Serigos signing the guest book with Adviser for Latin America J. Salicio Diez; visiting the ATLAS experimental cavern with Spokesperson D. Charlton (Spouse, Son and First Secretary present).

  7. Silêncios, os Sons dos Rios, os Sons das Cidades: Los Muertos e Liverpool

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    COSTA, Fernando Morais da

    2012-04-01

    Full Text Available This arcticle aims to analyze the relation between sounds and images in Lisandro Alonso’s Los Muertos and Liverpool. It is of our interest to think about the narrative roles given to sound effects and ambient sounds, to speak of the importance given to such sound elements, opposite to the minor role played by music and dialogue, all that working within the cinematic regime of the sequence shot. Therefore, this work tries, most of all, to investigate how ambient sounds and diegetic noises contribute for such a particular temporal construction. It is also a secundary goal to establish some relationship between those films and other examples of a cinema that has declined the usual dialogue’s central narrative part, as well as to recall the ideia and definition of a cinema of poetry.

  8. ¿Qué son los observatorios y cuáles son sus funciones?

    OpenAIRE

    Noel Angulo Marcial

    2009-01-01

    La falta de consensos en cuanto a las funciones y definición del término observatorio en el ámbito de las ciencias sociales hace evidente que el concepto está en proceso de construcción. Sugiere también la necesidad de contar con elementos de referencia para su caracterización, además de precisar los atributos que le dan la calidad de observatorio; no obstante este es un espacio abierto a la investigación y desde luego a la creatividad y la innovación. Por su aplicación se asocia y articula c...

  9. Esas empeñadas luchas a que son muy aficionados los naturales de este país: un acercamiento a la etnicidad a través de la lucha canaria (1840-1943

    Directory of Open Access Journals (Sweden)

    Alonso, Víctor

    2016-06-01

    Full Text Available Sports in general, and traditional sports in particular, make a key contribution to the processes linked to the configuration of any identity. These activities can be studied as a reality «in its own right» (with a certain relative autonomy, as a part of a specific social subject, or as a diacritical social matter that enables us to characterize structures and social processes which, over time, could favour the changes, meanings and visions, whether considered legitimate or maligned, that are contained in these practices. This article deals with the traditional sport of lucha canaria [Canary-island wrestling], which has proved a revealing historical construct, to the extent that this popular game turned sports discipline underwent intense transformation during the 19th and early- 20th centuries. Its analysis provides an insight into the different social meanings, supports and principles associated with this activity, revealing a complex space of relations where the indigenous Guanche, historical tradition and an ongoing link with modernity are particularly relevant. All of this endorses the debate in recent decades in social anthropology and the social sciences regarding ethnicity, identity and sports.El deporte, y especialmente los deportes tradicionales, son una contribución de primer orden a los procesos de construcción identitaria. Puede ser estudiado como realidad «en sí» (dotada de relativa autonomía, al modo de un campo social específico, o bien en modo de diacrítico social que permite caracterizar unas estructuras y procesos sociales que, a lo largo del tiempo, favorecen las transformaciones, sentidos y visiones legitimadas o denostadas contenidas en las prácticas. Este artículo trata la lucha canaria, un deporte tradicional que se manifiesta como constructo histórico revelador, al tratarse de un juego popular deportivizado que vive una intensa transformación a lo largo del siglo XIX y las primeras décadas del XX. Su

  10. La Première guerre carliste ou la guerre de la dernière chance : la communauté légitimiste face à son destin

    Directory of Open Access Journals (Sweden)

    Laetitia Blanchard Rubio

    2011-06-01

    opinion, essentially through the press and some magazines, but also through numerous circumstantial works that mostly are testimonies of soldiers having taken part to the conflict. This article will develop an analysis of the argument of the European legitimists that have been part of the first Carlist war as observers or active participants in a conflict which challenges went well beyond a mere dynastic dispute. An unfavourable conclusion for carlism in that civil war would mean for them the end of the legitimist influence in Europe. They are conscious that those fights could seal the fate of the legitimist cause. The possibility to fight for ideals that they could not always defend in their own countries leads some officers to engage into the Carlist army, but also to publish some works due to celebrate the heroism of their own party. Those defenders of legitimacy aim at meeting a collective memory, the one of the defeated that would deny them the right to existence. They are conscious that the present does not belong to them anymore and place all their hopes in the future and in the mark they will leave in History that, some day maybe, will do justice to them.Cuando empieza la primera guerra carlista en España, es allí donde parece ventilarse la suerte del absolutismo europeo que se enfrenta con un liberalismo cada vez más poderoso. Los actores de esta contienda así como el eco de ciertas batallas despiertan el interés de la opinión pública europea esencialmente a través de la prensa pero también a través de numerosos escritos de circunstancias que son la mayoría de las veces testimonios de militares comprometidos en esta contienda. En este artículo, se trata de analizar el discurso de los legitimistas europeos que participaron en la primera guerra carlista como observadores o actores de una guerra en la que lo que estaba en juego iba mucho más allá de un simple pleito entre dos monarcas españoles. Un desenlace desfavorable al carlismo en esta guerra

  11. ¿Qué indicadores son considerados por enfermería para conseguir una diálisis perfecta en el paciente en hemodiafiltración en línea?

    Directory of Open Access Journals (Sweden)

    Ana Vanessa Fernández Martínez

    2012-06-01

    Full Text Available Tanto las guías, como las indicaciones del Grupo de Gestión de Calidad de la Sociedad Española de Nefrología nos proponen una serie de indicadores para medir la calidad de la prestación de la hemodiálisis. El objetivo del presente estudio fué, tras conocer cuales son los principales indicadores de una diálisis óptima para el personal de enfermería, evaluar objetivamente cada sesión de diálisis, en el convencimiento de que del conocimiento de los aciertos/fallos de cada sesión, obtendríamos propuestas de mejora de una forma más precoz que con los indicadores comúnmente utilizados. Para ello, se realizó una encuesta entre el personal de enfermería (n=26 solicitándole que enumerara los 10 parámetros que le parecían fundamentales para una sesión de diálisis óptima. Los 10 ítems más nombrados se utilizaron para elaborar la hoja de recogida de datos, con respuestas si/no. En cada paciente (n=160 se analizaron 3 sesiones consecutivas (n=480 sesiones, con la misma pauta de tratamiento. El enfermero que realiza las sesiones desconoce que sesiones se van a evaluar, así como la identidad de un segundo enfermero evaluador, que será el encargado de marcar si/no en cada uno de los ítems. Por cada objetivo conseguido se otorga 1 punto. La puntuación máxima por cada paciente es de 30 puntos (10 por sesión, excepto en los portadores de catéter tunelizado, en los que es de 27 puntos (9 por sesión, al no ser procedente valorar la hemostasia. Hemos obtenido como resultado que el 41,3% de las sesiones realizadas obtuvieron la máxima puntuación (42,1% con Fístula arteriovenosa y 35,1% con catéter tunelizado, p=0,043. La puntuación porcentual obtenida fue 88,7 ± 11,9%, porcentaje significativamente mayor con FAV que con catéter (89,9 ± 9,9 versus 79,7 ± 19,4, p<0,001. No se aprecian diferencias por sexo, edad, etiología o permanencia. 30 pacientes (18,8% obtienen la puntuación máxima en las tres sesiones. El 77,7% de los

  12. Être tenu par son erreur : les conséquences du fait de se tromper Remaining Caught up in Error: The Consequences of Being Wrong. An Example Based on Schütz’s Don Quixote

    Directory of Open Access Journals (Sweden)

    Nicolas Marquis

    2011-09-01

    Full Text Available Peut-on sortir indemne de ses erreurs ? En empruntant une voie dessinée par les recherches récentes relatives au fait de se tromper qui se démarquent d’une appréhension purement cognitiviste, cet article vise à explorer ce que fait l’erreur à la personne qui la commet. L’hypothèse qui est développée à la suite de Wittgenstein est que chaque acte, chaque contenu cognitif qui se verra qualifié d’erreur “tient” la personne, et risque de porter à conséquence sur la manière dont l’auteur de l’erreur pourra s’engager dans le monde. Il est ainsi possible de proposer une classification des erreurs en fonction du réarrangement qu’elles impliquent dans le système de ce que la personne sait, croit, vit. Afin d’approfondir cette hypothèse, l’article s’appuie sur le fameux texte d’A. Schutz intitulé Don Quichotte et le problème de la réalité. Le phénoménologue y analyse la manière dont le héros fantasque de Cervantès, figure extrême de ce que nous sommes au quotidien, s’arrange un temps pour continuer à vivre dans son sous-univers de chevalerie grâce à un environnement bienveillant, mais aussi comment le chevalier auto-proclamé sera inéluctablement amené à qualifier d’erreur l’ensemble de ce qu’il sait, croit ou vit lorsque le monde qui l’entoure se fera confrontant.Can we emerge unscathed from our errors ? In taking a path sketched out in recent research on the fact of being wrong that distances itself from a purely cognitivist understanding, this article seeks to explore what an error does to the person who makes it. The hypothesis that is developed, following Wittgenstein, is that every act, every cognitive content that ends up being described as error has “a hold” on the person and risks having consequences on the way the error’s author will be able to involve him/herself in the world. Hence it is possible to propose a classification of errors according to the rearrangement

  13. "Escute, pai": diálogos entre filhos(as e pais em canções populares brasileiras "Listen to me, dad": dialogs between fathers and sons in Brazilian popular music

    Directory of Open Access Journals (Sweden)

    Maura Penna

    2010-12-01

    Full Text Available As relações entre pais e filhos(as configuram um tipo particular de relação entre gerações, na medida em que ocorrem no seio da família, instituição social marcada por vínculos de dependência e responsabilidade e por laços emocionais. Diversas canções que têm essas relações como tema são reunidas no CD Como nossos pais (2008, que exemplifica a tendência, também presente na indústria fonográfica, de preservação da produção musical, na medida em que apresenta diversas gravações com datas entre 1966 e 1988. Deste CD, selecionamos três canções que claramente configuram uma fala filial dirigida ao pai como interlocutor: Papai me empresta o carro (de Roberto de Carvalho e Rita Lee; Já fui (de Marina Lima e Antônio Cícero; Pai (de Fábio Jr.. Numa análise que articula contribuições da sociologia e da psicologia, mostramos como essas canções revelam diferentes momentos do processo de conquista da maturidade e da autonomia pelos jovens, com suas contradições, refletindo também as transformações sociais na configuração da família e no comportamento sexual. Discutimos, ainda, com base na tipologia proposta por TATIT, como essas canções tratam diferentemente a relação entre letra e melodia.The relationships between parents and their children configure a specific part of the relationship between generations, as they occur on the nucleus of the family, which is a social institution linked together by dependency, responsibility and emotional bounds. Several songs which have these relationships as a theme are grouped on the album Como nossos pais (2008 (Like our parents. This album exemplifies a tendency, also present in the phonographic industry, of the preservation of musical production, as it presents several recordings from dates varying between 1966 to 1988. From this album, we have selected three songs that clearly fits the scenario of a son/daughter speaking to his/her father: Papai me empresta o carro

  14. Principes de détermination de la peine, politiques publiques et modération en matière de recours à l’incarcération : la rupture du Canada avec son histoire

    Directory of Open Access Journals (Sweden)

    Anthony N. Doob

    2012-05-01

    Full Text Available Bien que le Canada n’ait jamais réussi à atteindre une grande cohérence en matière de détermination de la peine, pendant plus d’un siècle, les taux d’incarcérations y sont demeurés constants, alors que d’autres pays, notamment les États-Unis, ont vu leurs niveaux d’emprisonnement augmenter considérablement. Une explication partielle de cette stabilité réside dans la tradition canadienne de scepticisme à l’égard des bénéfices de l’emprisonnement – une position qui fut jusqu’en 2006 partagée par les gouvernements fédéraux libéraux et conservateurs. Toutefois, les juges chargés de prononcer les peines n’ont jamais reçu de directives claires du Parlement sur les objectifs qui devraient être concrètement associés aux décisions portant sur les sentences. Les politiques de détermination de la peine basées sur des principes clairs ont connu un rapide déclin à partir de 2006 avec l’introduction par les Conservateurs de nombreux projets de lois pénales modifiant l’économie de la punition. Dans son ensemble, cette activité législative représente l’antithèse d’une réforme de la justice pénale réfléchie et fondée sur des principes. En 1999, Jean-Paul Brodeur décrivait les valeurs qui sous-tendaient les politiques de détermination de la peine comme « rien de moins qu’une catastrophe morale ». Il ne fait aucun doute sur la manière dont il aurait qualifié la période qui s’est amorcée en 2006.Although Canada has never achieved coherence in its sentencing policy, it has managed, for over a century, to maintain a fairly constant level of imprisonment even at a time when other countries, most notably the US, have experienced large increases in imprisonment. A partial explanation for Canada’s stability is that Canada has a long history of scepticism about the value of imprisonment – a view that, until 2006, was endorsed by both Liberal and Conservative national governments

  15. ¿Son las herramientas recomendadas por la ASPEN y la ESPEN equiparables en la valoración del estado nutricional? Are the tools recommended by ASPEN and ESPEN comparable for assessing the nutritional status?

    Directory of Open Access Journals (Sweden)

    M.ª A. Valero

    2005-08-01

    Full Text Available Introducción: No existe un método de valoración nutricional universalmente aceptado. Los expertos de ASPEN (2002 sugieren utilizar la valoración subjetiva global (VSG, mientras que los de ESPEN (2002 recomiendan el sistema NRS-2002. Objetivos y ámbito: Este estudio transversal tiene como objetivos: 1 conocer la prevalencia de malnutrición al ingreso hospitalario en un hospital terciario y 2 conocer el grado de asociación entre dos herramientas utilizadas para valorar el estado de nutrición: la VSG y el sistema NRS-2002. Material y métodos: Se estudian 135 pacientes (42,2 % mujeres y 58,8 % varones, edad 62,1 ± 14,5 años en los tres primeros días del ingreso hospitalario, ingresados en camas de Medicina Interna y Cirugía. Se analizan diferentes variables del estado nutricional. Se compara las necesidades calóricas (Harris Benedict x factor de agresión y la ingesta calórica del día anterior al ingreso, mediante recordatorio de 24 horas. Se calcula la prevalencia de malnutrición al ingreso con dos herramientas de screening: VSG y el sistema NRS-2002. Resultados: El 42,2 % de los pacientes reconocen haber perdido peso y el 39,3 % ingieren una dieta inferior a sus necesidades al ingreso en el hospital. Según el método utilizado de valoración nutricional, la prevalencia de malnutrición es del 40,7 y del 45,1/100 pacientes ingresados con el VSG y el NRS-2002, respectivamente. Existe una asociación significativa entre los resultados obtenidos con ambas herramientas (p = 0,000. Los niveles de albúmina sérica y linfocitos totales son inferiores en los pacientes malnutridos. Conclusiones: La prevalencia de malnutrición al ingreso hospitalario es elevada. Existe una asociación estrecha entre los resultados obtenidos con la VSG y el sistema NRS-2002. Aunque en la práctica clínica cualquiera de los dos métodos puede ser utilizado para valorar el estado de nutrición, consideramos que el sistema NRS-2002, aunque más complejo, es

  16. Plantilla de enfermería y demanda de cuidados de ancianos hospitalizados, ¿son suficientes los recursos? Nursing staff and care needs in hospitalized elders, are there enough resources?

    Directory of Open Access Journals (Sweden)

    Alfonso Jesús Cruz Lendínez

    2007-12-01

    Full Text Available Introducción: El aumento de la población de personas mayores de 65 años hace cada vez más frecuente su ingreso en los hospitales. El tiempo de estancia hospitalaria de los ancianos suele ser más prolongado que el del resto de pacientes. Objetivo: Analizar la capacidad de prestación de cuidados de 3 unidades de hospitalización de un hospital público y compararla con la demanda de cuidados de los ancianos. Métodos: Estudio prospectivo observacional en 3 unidades de hospitalización de medicina interna de un hospital universitario de la red pública de Andalucía (España. Se ha incluido una muestra de 190 pacientes ancianos hospitalizados. Las variables recogidas fueron: demográficas, relacionadas con la hospitalización, demanda de cuidados y capacidad de prestación de cuidados de la plantilla de enfermería. Los datos se han obtenido del sistema de información del hospital, del conjunto mínimo básico de datos de pacientes y por observación directa mediante el método de nivel de cuidados (MNC. Resultados: La edad media de los ancianos hospitalizados fue de 77,4 años, con 21,1% de mayores de 85 años. La estancia media fue de 15,68 días. La estimación de la capacidad de prestación de cuidados de la plantilla de enfermería fue de 2,8 horas/paciente/día (con un índice de enfermeras tituladas del 60%. A partir de la medición de niveles de dependencia, la demanda de cuidados media de los ancianos fue de 4,9 horas/paciente/día. Esta diferencia supone un déficit anual de 51 profesionales de enfermería en la plantilla de las 3 unidades de hospitalización. Los factores que influyen en la demanda de cuidados de los ancianos son la edad, días de estancia hospitalaria, el diagnóstico médico y el destino del paciente al alta. También se encuentra una relación con la presencia de un familiar acompañando al paciente (cuidador familiar. Los cuidados básicos representan un 65,7% del total de cuidados requeridos. Conclusiones: La

  17. Influence de l'énergie de surface d'un tambour deshuileur sur son efficacité de relevage Influence of the Surface Energy of a Deoiling Drum on Its Gathering Efficiency

    Directory of Open Access Journals (Sweden)

    Aurelle Y.

    2006-11-01

    Full Text Available Au cours de cette étude est analysée l'influence de l'énergie de surface d'un tambour déshuileur sur son efficacité et sa sélectivité de relevage. Quatre tambours en acier inoxydable, en polychlorure de vinyle, en polypropylène et en dérivé fluorocarboné de tensions critiques de mouillage différentes sont testés comparativement en fonction de l'histoire de leur expositionvis-à-vis de phases hydrocarbure (kérosène et eau. Les essais réalisés montrent que seuls les tambours en dérivé fluorocarboné de très faible tension critique de mouillage s'avèrent intéressants pour des utilisations industrielles. En effet, ils présentent un comportement indépendant de l'histoire de leur exposition ce qui les rend très faciles à utiliser, sans précautions particulières, du fait de leur très grande sélectivité vis-à-vis des hydrocarbures. Par contre, les autres tambours, qui présentent des contributions polaires non négligeables à leur énergie de surface, ont des comportements vis-à-vis des hydrocarbures fonction de l'histoire de leur exposition et ne s'avèrent pas sélectifs vis-à-vis des hydrocarbures à récupérer. The aim of this article is to analyze the influence of the surface energy of a deoiling drum on its gathering efficiency and selectivity. The project consists in testing drums having the same size but made of materials having different surface energies so as to evaluate the influence of this key parameter that had previously been poorly analyzed. Four materials were chosen : stainless steel, polyvinyl chloride, polypropylene, and a fluorocarbon derivative. These materials are representative, a priori, of the behavior of most materials because of the position of their critical wetting tension (gamma c compared to the superficial tension values of water (72 dyn/cm and the hydrocarbon phases to be gathered (25 to 35 dyn/cm (Fig. 1. It should be noted that the fluorocarbon derivative drum tested was patented by

  18. 儿子养老还是女儿养老?基于家庭内部的比较分析%Sons or Daughters?Who Are Caring for Aging Parents:A Gender Comparative Study of Chinese Family

    Institute of Scientific and Technical Information of China (English)

    许琪

    2015-01-01

    本文使用2010年中国家庭追踪调查数据,通过家庭内部比较,从经济支持和生活照料两个方面对儿子和女儿的赡养行为进行系统的比较研究。结果发现,在当代中国家庭中,儿子在赡养父母时的总效应依然显著大于女儿,这主要是因为他们更可能与父母同住。一旦控制子女与父母的居住方式,儿子的直接效应就仅在经济支持方面大于女儿。在生活照料方面,女儿的直接效应已经显著超过儿子。从城乡对比来看,这种“儿子出钱、女儿出力”的性别分工模式主要出现在农村。在城市,女儿在经济支持和生活照料两个方面的直接效应都超过儿子。所以,中国传统的以儿子为核心的赡养方式虽然没有彻底瓦解,但已发生明显变化,快速的人口转变和女性社会经济地位的提高是导致这些变化的重要原因。%The traditional Chinese family has long been characterized as patriarchal,patrilineal, and patrilocal, placing women at a severe social disadvantage in relation to men.Under srch a system,sons were permanent members of the natal family and were expected to live with parents after marriage and contribrte to their economic well-being.In contrast,darghters were temporary members of the natal family.Upon marriage,a woman was expected to serve her hrsband's extended family and bore no filial obligation to her own parents.Nevertheless,in recent years some strdies have fornd that the tradition of sons as the sole provider for aging parents has rndergone significant changes in contemporary China.To frrther investigate this issre, orr strdy examines two aspects of intergenerational srpport:financial srpport and aging care, and highlights the gender difference between sons and darghters in this regard.Taking into consideration of the commonly practiced patrilocal living arrangement in China, we separate the gender difference between sons and darghters in care

  19. 超越自然主义的自然主义作品*--美国黑人经典小说《土生子》写作特征探析%A Naturalism Literature Work Beyond Traditional Naturalism-An Analysis on the Writing Characteristics of Native Son

    Institute of Scientific and Technical Information of China (English)

    罗青

    2015-01-01

    19世纪末20世纪初是自然主义文学蓬勃发展的时期,自然主义理论从欧洲大陆传播到美国,在美国本土形成了独特的自然主义理论。美国黑人作家理查德・赖特的代表作《土生子》就成功地采用了自然主义的创作手法,作为美国黑人文学史上的一个里程碑,它不仅体现了美国自然主义文学的特征,同时对原有的自然主义理论有所超越。笔者从美国自然主义文学的特征出发,对比分析“赖特式”的自然主义在《土生子》中的具体表现。%Naturalism Literature experienced a vigorous development in the period of the late nineteenth cen-tury and the early twentieth century.The theory of Naturalism had been spread from Europe to America and had formed a unique Naturalism theory there.Richard Wright, a famous African American writer, successfully applied the theory of Naturalism to his representative work Native Son.Native Son, as a milestone in the history of African American Literature, not only reflects the traits of traditional Naturalism, but also transcends the original theory. This paper will compare and analyze the characteristics of Naturalism which reflected in Native Son from the per-spective of American Naturalism Literature.

  20. 宋代给侍之法:"养儿防老"的古代实践%The Law of Gei-Shi in Song Dynasty: the Ancient Practice of the Concept of "Bring up Sons to Support Parents in their Old Age"

    Institute of Scientific and Technical Information of China (English)

    石璠

    2015-01-01

    为保证老年人能够得到儿子的居家侍养,宋代继承了前代的给侍之法,包括侍丁免役、侍丁的刑罚变通以及禁止"委亲之官"等制度.但由于时代的变迁,上述制度在宋代又有所变化:其侍丁免役制度似乎呈现出弱化的趋势;由于折杖法的实施,侍丁在刑罚上的优待主要体现在编配等刑的变通执行上;"委亲之官"之禁出于平衡忠孝的动机,也有了一些变通的方法,包括给予解官侍亲者重新朝参注官的机会、给予有养老责任的职官以就近注官的便利等.%In order to ensure the old man can get son's support at home, Song Dynasty inherited the law of Gei-Shi. By means of regulations of exempting from service, probation, changing punishment, and resigning to go back home, the son who had parents to support could avoid defaulting their responsibility because of "official business" or punishment. Under the changes of social, institution of service-exempt weakened in Song Dynasty.Because of enforcement of Zhe-Zhang-Fa, the son's legal privilege consisted on the relieving of punishment such as Bian-Guan and Pei-Yi. In order to balance loyalty and iflial piety, there were some provisions in Song Dynasty which authorized resigned ofifcials to resume their career while prohibiting Wei-Qin-Zhi-Guan, and permitted ofifcials to work in local ofifce while demanding assignment evasion.

  1. “Aquí no pasó nada. Las mujeres al fin y al cabo son para eso”. El uso de la violencia sexual contra las mujeres como arma de guerra en el siglo XXI: estudio de caso sobre Darfur

    OpenAIRE

    Urteaga Villanueva, Katia

    2012-01-01

    Esta investigación profundiza una reflexión sobre la violencia sexual contra las mujeres usada como arma de guerra en los conflictos armados, analizando en el caso concreto de Darfur si se trata de una estrategia bélica desplegada por un actor armado contra las mujeres como un sector específico de la población, con toda la intensión de herir a las mujeres y romper el tejido social de sus comunidades, bajo el entendimiento cultural que sus cuerpos son un territorio más del conflicto que hay qu...

  2. Görme Engellilere Yönelik Kütüphanecilik Hizmetlerinde Türkiye'deki Son Gelişmeler: Gazi Üniversitesi Merkez Kütüphanesi Görme Engelliler Bölümü Örneği

    Directory of Open Access Journals (Sweden)

    Meliha Kazak

    2008-06-01

    Full Text Available Bu makalede görme engellilerin kullandığı Braille alfabesinin tarihçesi, görme engellilere yönelik kütüphanecilik hizmetlerinde Türkiye 'deki son gelişmeler ve bu hizmetlerin verilmesinde karşılaşılan sorunlar ile çözüm önerileri yer almaktadır. Ayrıca Gazi Üniversitesi Görme Engelliler Bölümü 'nün kuruluşu, gelişimi, kullanıcılarına sunduğu hizmetler ve ileriye yönelik hedefleri anlatılmaktadır.

  3. L'Homme, ses ressources et son environnement, dans l'Ouest de la France à l'âge du Fer : actualités de la recherche. Actes du Séminaire Archéologique de l'Ouest.

    OpenAIRE

    Mougne, Caroline; Daire, Marie-Yvane

    2015-01-01

    National audience Le présent volume constitue les actes du Séminaire d’Archéologie de l’Ouest (SAO) qui s’esttenu à l’Université de Nantes le 24 mars 2014 et qui avait pour thématique : L’Homme, sesressources et son environnement, dans l’Ouest de la France à l’âge du Fer.Ce rapport de l’Homme à la nature qui l’entoure est une problématique dont l’actualité nousmontre chaque jour à quel point elle est présente et fondamentale dans l’organisation des sociétés,modernes comme anciennes. La que...

  4. La banane : de son origine à sa commercialisation

    Directory of Open Access Journals (Sweden)

    Lassois L.

    2009-01-01

    Full Text Available Banana: from origin to market. Cultivated bananas are giant herbaceous plants within the genus Musa. They are both sterile and parthenocarpic. There are well over a thousand domesticated Musa cultivars, they are mostly triploid (a few are diploid or tetraploid and are derived from crosses between two wild species, Musa acuminata and Musa balbisiana. In terms of production, bananas are the fourth agricultural product after rice, wheat, and maize. They constitute the basis of food security for many people. Cropping systems vary widely around the world and contrasting objectives are encountered: consumption by the producer, sale on local or national markets, export, etc. Cooking bananas, including plantains, must be distinguished from dessert bananas, which constitute a major international trade. This international trade started only in the early 1900s but it has since grown continuously. Banana is currently the most exported fruit, in terms of both value and quantity. Despite the high genetic diversity found within the genus Musa, the export market is mainly based on single Cavendish. There are major challenges to banana production from biotic or abiotic stresses to continue to meet the criteria of sustainability, quality and yield that are imposed.

  5. Cuando alguien habla la maya, se nota que son pobres

    Directory of Open Access Journals (Sweden)

    Elizabeth Bellon Cárdenas

    2010-06-01

    Full Text Available En este trabajo se examinan las narrativas de identidad de los receptores culturalesde la radiodifusora indigenista “La Voz de los Mayas, Xepet”, respecto de su relacióncon la oferta radiofónica de esta emisora ubicada en la cabecera municipal de Peto,al sur de Yucatán, México. El propósito es, por un lado, sistematizar, desde el análisisargumentativo, el uso, estructura y estrategias argumentativas de los maya hablantesradioescuchas de Xepet (bilingües o monolingües en torno a la oferta cultural de lamisma, así como a la presencia cotidiana de esta emisora en su mundo de vida; y, porotro, reflexionar acerca de la radio indigenista en México como un recurso que podríacontribuir a la “cultura de paz”.“U chíikul u t’aan maayao’ob” o “La voz de los mayas”, salió al aire el 29 de noviembrede 1982, en la frecuencia de los 740 khz de AM y fue reubicada al 730 en enero de2001. Su área de cobertura abarca unos 100 km a la redonda, alcanzando cerca de milcomunidades de la península y parte de Quintana Roo, con una audiencia potencial de500 mil personas. Su programación incluye géneros musicales y no musicales, compuestosestos últimos por programas informativos, de difusión cultural, servicio e infantiles.Xepet ha sido una de las radiodifusoras pioneras del sistema indigenista promovido porel Estado mexicano desde 1979, modelo que habría de extenderse en las más de veinteemisoras que aparecieron después. Hoy en día, la crítica respecto de la función, contenidosy operación de estas emisoras “oficiales” o “voceras del Gobierno” permanence,debido a que tanto la práctica indigenista como su experiencia radiofónica parecieranestar rebasadas por las demandas de los pueblos indios que reivindican su derecho a lalibre determinación y a la autonomía, así como a la propiedad y gestión de sus propiosmedios de comunicación. Lo anterior reitera la necesidad de una propuesta radiofónicaque se constituya en interlocutor válido para los mayas yucatecos.Alejándonos de quienes de manera simple celebran la diferencia cultural del “mundoglobalizado” al igual que la “interculturalidad” como la integración, convivencia o relaciónpacífica de elementos de distintas culturas de forma “más o menos satisfactoria”,recordamos que la relación entre grupos diferentes siempre implicará luchas simbólicaspor el reconocimiento y, en consecuencia, un proceso incesante de reconfiguración deidentidades y de su poder. Con base en el análisis argumentativo de las narrativas de losmayas yucatecos en torno a la “escucha” de Xepet, advertimos que la radio podría serun recurso para, a través de la lengua, evocar la memoria colectiva de quienes afirmanno hablar “la maya auténtica” o no ser los “verdaderos mayas” sino tan sólo “mayeros”,“los que hablan la maya”. La radio como un instrumento para recordar, afirmar,apropiarse y reconfigurar algunos elementos de la identidad, constituyéndose comoun espacio de diálogo hacia una “cultura de paz”. Conformarse con el valor simbólicode las emisoras indigenistas sería ignorar, una vez más, las demandas actuales de estospueblos, que exigen una comunicación en donde no sólo se hable su lengua, sino quese escuche su voz.

  6. ¿Qué son las conjunciones y disyunciones borrosas?

    OpenAIRE

    Alsina Català, Claudi

    1996-01-01

    En este artículo se presenta una aproximación intuitiva a las conjunciones y disyunciones propias de la lógica borrosa, con especial referencia a sus modelizaciones matemáticas y a sus interpretacion

  7. La reciprocidad y el don no son la misma cosa

    Directory of Open Access Journals (Sweden)

    Ricardo Gabriel Abduca

    2007-12-01

    Full Text Available El autor se propone mostrar por qué la noción de reciprocidad, aunque ha sido muchas veces tomada como sinónimo del fenómeno de intercambios de dones, corresponde a diversas situaciones sociales, por lo cual tiene poca utilidad descriptiva y explicativa. Examina algunos hitos de la historia antropológica, mostrando que más que un concepto, 'reciprocidad' es un palimpsesto sobre el cual, de Durkheim a Polanyi, se han ido escribiendo variadas nociones. En cambio, sugiere una definición de don más estricta, cercana a las ideas de Mauss y acorde con los avances de la etnografía y la teoría contemporánea. Sugiere distinguir entre circuitos cerrados de dones, donde circulan bienes de consumo final, y circuitos abiertos, donde los dones que circulan condensan el conjunto de las relaciones sociales.O objetivo deste texto é mostrar que a expressão 'reciprocidade', ainda foi considerada como sinônimo de 'câmbio de domes', é outra coisa. O autor sugere um breve esquema de alguns marcos do desenvolvimento da noção de 'reciprocidade' em a teoria antropológica, mostrando que o sentido dela expressão foi mudando até assemelhar um palimpsesto com múltiplas rescritas, no processo que vá de Durkheim a Polanyi. Defende um conceito de dom próximo às idéias de Mauss e a certos avances dela etnografia contemporânea e a teoria social. Distingue deus tipos de circuitos de circulação de domes: fechados, onde circulam bens de consumação direita, e apertos, onde circulam certo tipo de bens que condensam o conjunto das relações sociais.The aim of this text is to show how the notion of 'reciprocity', although have been considered a synonymous of gift exchange, veils different social situations. A brief survey of the history of the use of the word shows how 'reciprocity', from Durkheim to Polanyi, seems as a palimpsest of various notions. Although, he essays a defense of a concept of 'gift' related to the Maussian texts, and closer to some issues of recent ethnography and social theory. He distinguishes two types of gifts paths: closed, where final consumption goods circulates, and open ones, where we find not-consumption goods, which resume the whole of social relationship.

  8. Le plateau des Guyanes et son potentiel minier

    OpenAIRE

    Théveniaut, Hervé; Billa, Mario; Cassard, Daniel; Delor, Claude; Maldan, Frédérik

    2011-01-01

    Deux milliards d'années nous contemplent lorsqu'il est question de la Guyane. Ce sous-sol précambrien du bouclier des Guyanes possède une histoire riche, complexe et des ressources minérales que les géologues scrutent attentivement depuis des décennies. L'or, le fer, la bauxite, le diamant et d'autres substances sont présentes du Venezuela au Brésil en passant par la Guyane. Comprendre, rechercher, identifier pour mieux exploiter sont les objectifs qui s'inscrivent dans les attentes de la soc...

  9. Pescados procesados: ¿son todos recomendables para pacientes renales?

    Directory of Open Access Journals (Sweden)

    María Isabel Castro-González

    2009-01-01

    Full Text Available Es indispensable un buen manejo nutricional en pacientes renales. La dieta debe incluir proteína de buena calidad con cantidades limitadas de fósforo (P y potasio (K. Los ácidos grasos n-3 (AGPIn-3 de los pescados proporcionan beneficios contra la progresión del daño renal. El objetivo fue evaluar el contenido de proteína (PR, (P, (K, calcio (Ca y AGPIn-3 en pescados procesados como una opción para pacientes renales. Se analizó atún en agua (AA, en aceite (AAC, sardina en tomate (ST, en chipotle (SC y salmón ahumado (SA. (SA presentó la mayor concentración de (PR, (P y (K y la menor cantidad de (AGPIn-3. Las sardinas presentaron el doble de la concentración de (P y (K en comparación con los atunes, así como (Ca en elevada concentración. Atunes y sardinas tuvieron altas concentraciones de AGPIn-3 (4256-5213 mg/100g; las relaciones P:AGPIn-3 y K: P:AGPIn-3 fueron muy bajas (0.03 a 0.06, para atunes y sardinas, respectivamente; (AA y (AC aportaron (10.1 y 11.1 mg(P/g(PR; (ST (26.4 y (SC(19.1. AGPIn-3/g(PR fue similar para atunes y sardinas (302-424. Se detectó diferencia significativa para (P y (K entre tipos de pescados. Se recomienda incluir de manera individualizada (AA y (AC en la dieta de pacientes renales, no así el consumo de sardina y salmón.

  10. Dessiner son parcours professionnel, pour en tirer des enseignements

    OpenAIRE

    Pascale Corten-Gualtieri; Sylvie Dony; Evelyne d’Hoop

    2010-01-01

    Dans le cadre de la formation continue pour des enseignants du supérieur, une activité d’expression visuelle a soutenu une posture réflexive à propos du développement professionnel de chacun. Il a été demandé aux enseignants de dessiner leur parcours professionnel en le comparant à un parcours routier. Ce dessin a ensuite servi de support aux enseignants pour dégager les leviers et les freins de leur développement professionnel, puis pour clarifier leur(s) perspective(s) d’évolution professio...

  11. La banane : de son origine à sa commercialisation

    OpenAIRE

    Lassois L.; JP Busogoro; Jijakli H.

    2009-01-01

    Les bananiers cultivés sont des herbes géantes appartenant au genre Musa. Ils produisent des fruits qui sont à la fois stériles et parthénocarpiques. Il en existe plus de 1 000 variétés et ce sont généralement des clones triploïdes (parfois diploïdes ou tétraploïdes) issus principalement de croisements entre deux espèces sauvages séminifères, Musa acuminata et Musa balbisiana. En termes de production mondiale, la banane est le quatrième produit agricole après le riz, le blé et le maï...

  12. What Carnot's Father Taught His Son about Thermodynamics

    Science.gov (United States)

    Muller, Erich A.

    2012-01-01

    The historical development of the classical postulates of the second law of Thermodynamics can be traced back to the book by Sadi Carnot, "Reflections on the motive power of fire." While unique in its own right and in some sense revolutionary, the book starts with an analogy between heat engines and waterwheels. Waterwheels were common engines of…

  13. BOOK REVIEW: Jean-Charles Houzeau et son temps

    Science.gov (United States)

    Sterken, C.; Verhas, P.

    2002-12-01

    This is a wonderful book. It describes the life and work of Belgian astronomer Jean-Charles Houzeau (1820-1888) and, as the last three words of the title indicate, it has a broader focus including the social, industrial and scientific context of the second part of the 19th century. This is set in a very broad international social context including social revolutions in Belgium and France, and the abolition of slavery in the United States. The biography clearly shows that this hard-working man was driven by science and justice, by individualism and generosity, by humor and sentiment. The book is divided in four parts, each part is placed in its own historical context. The first part "The apprentice, the master and his disciples" describes Houzeau's childhood and young years, his early scientific career at the Observatory in Brussels, and his relationship with Adolphe Quetelet. The evolution of this relationship is very well documented: the turbulent revolutionary Houzeau versus cool, moderated and diplomatic royalist Quetelet, the observer versus the mathematician theorist. But both were very dedicated teachers: Quetelet established public courses and after the Revolution of 1830 he contributed to the foundation of the University of Brussels; Houzeau was the peripatetic teacher wherever place he was, also after his return to Belgium. The second part is "The politician" and deals with Houzeau's political ideas and revolutionary attitudes and their consequences. His revolutionary ideas, though, were not confined to politics only: he also severely criticised the paucity of high-precision observations collected at the Royal Observatory in his days. Because he participated at revolutionary meetings, Houzeau was fired from his position at the Observatory by the Minister of Interior Affairs Charles Rogier. Thus started his peripathetic life, covering observational work in astronomy, geography, geodesy and natural sciences in many places in Belgium and abroad. The third part, "The separation", is a very interesting account of Houzeau's emigration to North America, in vain search for his revolutionary dream. Of course he also ran into trouble in the US due to publications such as "The white terror in Texas" and because of his loyalty with the slaves, his advocacy for black civil rights and his refusal to join the confederate army, so he had to flee Texas too. The book gives many details on the civil war era. His absence from Belgium led to a very significant scientific work, in the first place his most homogeneous and extensive star atlas (6000 stars to declination -65) which was made in very good atmospheric conditions by one and only one observer, totally independent from previously published catalogues. The last part "The builder" tells the story of the construction of the new Royal Observatory in the suburb of Uccle, a new and better site than the one established in the city center by the Dutch regime in 1826. When the succession of Adolphe Quetelet was discussed, Houzeau was about the only candidate with a vast publication record and a broad observational expertise. Surprisingly, he was appointed as the second director of the Observatory and remained in function till 1883. One chapter in the fourth part of the book deals with Houzeau's participation at a Venus transit expedition of 1882. Jean-Charles Houzeau made very significant contributions to astronomy and his major works include "Vade-mecum de l'Astronomie", the "Uranometrie Generale" and his monumental "Bibliographie Generale de l'Astronomie", an early precursor of our modern web-based ADS (NASA Astrophysics Data System). This is a book which every Belgian astronomer should read because it is an eye opener on the history of the establishment of the kingdom, and because it explains the roots and difficult early development of astronomy in this country. This history is internationally linked and refers to many contemporary scientists such as Argelander, Heis, Herschel, von Humboldt etc. The book by Verhas includes many details on observational techniques and geodetic triangulation, and explains very well the underlying principles of the described experiments. There are various nice diagrams and many high-quality photographic reproductions. Technically, the work is very well made and is printed on high-quality glossy paper. There are only a small number of typographical errors, and some low-resolution photographs have been reproduced on a scale much too large to be esthetic. The two-column format of 22 x 28 cm makes it very suitable for consultation at the library desk but not very adequate for armchair enjoyment or travel reading. The single shortcoming is the absence of a Name and Subject Index.

  14. Free Riders and Pious Sons: Why Science Research Remains Obligatory

    OpenAIRE

    Sarah Chan and John Harris

    2009-01-01

    John Harris has previously proposed that there is a moral duty to participate in scientific research. This concept has recently been challenged by Iain Brassington, who asserts that the principles cited by Harris in support of the duty to research fail to establish its existence. In this paper we address these criticisms and provide new arguments for the existence of a moral obligation to research participation. This obligation, we argue, arises from two separate but related principles. The p...

  15. "In my Opinion, most Tongzhi are Dutiful Sons!"

    OpenAIRE

    Miège, Pierre

    2011-01-01

    Based on interviews with young homosexuals in Hefei, Anhui Province, this article examines the precarious modes of socialisation of young tongzhi(a term often used by gay people to refer to themselves), centred on the Internet and small groups of friends. The difficulty they have in constructing an identity based on sexuality stands out in the context of social norms and roles they cannot resolve to defy, above all because of their feelings of respect and duty towards their parents.

  16. ¿Las universidades son organizaciones que aprenden adecuadamente?

    Directory of Open Access Journals (Sweden)

    José Miguel Rodríguez Antón

    2007-01-01

    Full Text Available En el presente trabajo se propone un Modelo de Organización que Aprende, basado en un Circuito de Conocimiento-aprendizaje organizacional y apoyado por una serie de fa- cilitadores que impulsan la conversión del conocimiento individual en organizativo, el cual es aplicado a una realidad concreta, es pecíficamente, la Facultad de Ciencias Económicas y Empresariales de la Universidad Autónoma de Madrid.

  17. Waar het jy ooit so'n achterstevoorom besigheid gehoor.....

    OpenAIRE

    2004-01-01

    Synopsis: Waar het jy ooit so n achterstevoorom besigheid gehoor...... In de drie boeken Het beloofde land van Adriaan van Dis, Tikoes van Henk van Woerden en Hondenhart van Breyten Breytenbach wordt een rondreis door de Karoo, ten zuiden van Kaapstad, in Zuid-Afrika beschreven. De drie boeken zijn geschreven en gepubliceerd nadat het hoogtepunt in de zwarte geschiedenis van Apartheid plaatsvond, nl. de vrijlating van Nelson Mandela in 1990. Met de vrijlating van Mandela werden onderhand...

  18. ¿Las personas mayores son testigos fiables?

    Directory of Open Access Journals (Sweden)

    Alaitz Aizpurua

    2011-07-01

    Full Text Available Imaginemos que en un juicio llaman a declarar como víctima o testigo a una persona mayor, situación cada vez más probable debido al envejecimiento de la población. En este artículo analizamos las diferencias entre jóvenes y mayores en la exactitud y fiabilidad del testimonio. Los mayores recuerdan con precisión aspectos representativos o la esencia del acontecimiento, pero recuerdan peor que los jóvenes detalles específicos. En pruebas de reconocimiento que requieren discriminar o verificar los hechos, las personas mayores tienen más falsas memorias y las experimentan como recuerdos verídicos en mayor medida que los jóvenes, produciendo así testimonios menos fiables.

  19. L'hypnose et son application en chirurgie.

    OpenAIRE

    Faymonville, Marie; Defechereux, Thierry; Joris, Jean; Adant, J. P.; Hamoir, Etienne; Meurisse, Michel

    1998-01-01

    Since 1992, we have used hypnosis routinely in more than 1400 patients undergoing surgery. We found that hypnosis used in patients as an adjunct to conscious sedation and local anesthesia was associated with improved intraoperative patient comfort, and with reduced anxiety, pain, intraoperative requirements for anxiolytic and analgesic drugs, optimal surgical conditions and a faster recovery of the patient. We reported our clinical experience and our fundamental research. Peer reviewed

  20. SemSon: Connecting Ontologies and Web Applications

    OpenAIRE

    Vanderhulst, Geert; LUYTEN, Kris; Coninx, Karin

    2010-01-01

    The emerge of semantic data on the web puts the development of dynamic web applications to the test. On the one hand, we witness more and more semantic information becoming available on the web. On the other hand, we can see web-based applications evolve from server-side applications to responsive client-side applications running in a web browser. In this paper we present a framework that bridges the gap between semantic data defined in OWL ontologies and client-side web applications imple...