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  1. Myeloablative radioimmunotherapies in the conditioning of patients with AML, MDS and multiple myeloma prior to stem cell transplantation; Myeloablative Radioimmuntherapien zur Konditionierung bei Patienten mit AML, MDS und multiplem Myelom vor Stammzelltransplantation

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    Buchmann, I. [Abt. fuer Nuklearmedizin, Universitaetsklinik Heidelberg (Germany)

    2008-06-15

    Aggressive consolidation chemotherapy and hematopoietic stem cell transplantation have improved the prognosis of patients with acute myeloid leukemia (AML), myelodyplastic syndrome (MDS) and multiple myeloma. Nevertheless, only a minor fraction of patients achieve long-term disease-free survival after stem cell transplantation with disease recurrence being the most common cause of treatment failure. In addition, therapy-related effects such as toxicity of chemotherapy and complications of stem cell transplantation increase mortality rates significantly. Myeloablative radioimmunotherapy uses radiolabeled monoclonal antibodies (mAb) with affinity for the hematopoietic marrow. It applies high radiation doses in the bone marrow but spares normal organs. Adding myeloablative radioimmunotherapy to the conditioning schemes of AML, MDS and multiple myeloma before stem cell transplantation allows for the achievement of a pronounced antileukemic/antimyeloma effect for the reduction of relapse rates without significant increase of acute organ toxicity and therapy-related mortality. In order to optimise therapy, a rational design of the nuclide-antibody combination is necessary. {sup 90}Y, {sup 188}Re and {sup 131}I are the most frequently used {beta}{sup -}-particles. Of these, {sup 90}Y is the most qualified nuclide for myeloablation. Backbone stabilised DTPA are ideal chelators to stably conjugate {sup 90}Y to antibodies so far. For myeloablative conditioning, anti-CD66-, -45- and -33-mAb are used. The anti-CD66-antibody BW250/183 binds to normal hematopoietic cells but not to leukemic blasts and myeloma cells. The {sup 90}Y-2B3M-DTPA-BW250/183 is the most suited radioimmunoconjugate for patients with an infiltration grade of leukemic blasts in the bone marrow < 25%. The specific doses (Gy/GBq) are 10.2 {+-} 1.8 (bone marrow), 2.7 {+-} 2 (liver) and < 1 (kidneys). In contrast, radiolabeled anti-CD33- and anti-CD45-antibodies bind to both, most of white blood cells and

  2. How I treat MDS and AML in Fanconi anemia.

    Science.gov (United States)

    Peffault de Latour, Régis; Soulier, Jean

    2016-06-16

    Fanconi anemia (FA) is the most frequent inherited cause of bone marrow failure (BMF). Most FA patients experience hematopoietic stem cell attrition and cytopenia during childhood, which along with intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their teens or young adulthood of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). To early identify and further predict bone marrow (BM) clonal progression and enable timely treatment, the follow-up of FA patients includes regular BM morphological and cytogenetic examinations. Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment of FA patients with MDS or AML. Although questions remain concerning HSCT itself (including the need for pretransplant chemotherapy, the best conditioning regimen, and the optimal long-term follow-up of such patients especially regarding secondary malignancies), clonal evolution in the absence of significant BM dysplasia and blast cells can be difficult to address in FA patients, for whom the concept of preemptive HSCT is discussed. Illustrated by 3 representative clinical vignettes showing specific features of MDS and AML in FA patients, this paper summarizes our practical approach from diagnosis through treatment in this particular situation. PMID:27020090

  3. Point mutations in the AML1/RUNX1 gene associated with myelodysplastic syndrome (MDS)

    International Nuclear Information System (INIS)

    Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells characterized by ineffective and inadequate hematopoiesis. MDS in a subset of patients arise after previous chemotherapy or radiation exposure for other malignancies. As MDS is a heterogeneous disorder, specific gene abnormalities playing a role in the myelodysplastic process have been difficult to identify. In this study, we analyzed the somatic mutations in the AML1/RUNX1 gene, which is a critical regulator of definitive hematopoiesis and the most frequent targets for translocation of acute myeloid leukemia (AML), in patients with MDS. We detected AML1 point mutations in 26 of 110 (23.6%) patients with refractory anemia with excess blasts (RAEB), RAEB in transformation (RAEBt) and AML following MDS (defined these categories as MDS/AML). Among 22 patients with radiation-related (including 14 atomic bomb survivors) and/or therapy-related MDS/AML, 11 (50%) patients had the AML1 mutations mostly in N-terminal region. In contrast, 15 of 88 (17%) patients with sporadic MDS/AML showed the AML1 mutations equally in both N-terminal and C-terminal region. The MDS/AML patients with AML1 mutations had a significantly worse prognosis than those without AML1 mutations. Most of AML1 mutants lost trans-activation potential, regardless of their DNA binding potential. These data suggested that AML1 point mutation is one of the major driving forces of MDS/AML, and these mutations may represent a distinct clinicopathologic-genetic entity. (author)

  4. Mechanisms of MDS/AML molecular pathogenesis in population exposed to radiation

    International Nuclear Information System (INIS)

    MDS (myelodysplastic syndrome) is a currently increasing hematological abnormality in A-bomb survivors (about 60 years after exposure), and is considered to be a pre-leukemic state since the disease progresses to AML (acute myeloid leukemia). This paper describes the outline of AML1 gene, its genetic alteration in the radiation-exposed population and the mechanism of progression from MDS to AML in AML1 mutants. AML1 (RUNX1) codes an essential transcriptional factor for hemopoiesis. Recently, the point mutation of AML1 has been implicated as a major molecular pathogenesis of MDS/AML as seen by its high frequency in the patients exposed in Hiroshima (36% vs 17% in non-exposed), in a population of Chernobyl nuclear accident, in the patients in Semipalatinsk nuclear test site (39%), and also in patients treated with radio-/chemo-therapy of malignancies like lymphoma. The mutation in MDS/AML patients can roughly classified in 4 types, resulting in proteins with different functions, all of which lack the transcription activating function. In the 4 types, the clinical feature of patients with Ni type (N-terminal, inframe, missense mutation) is known to be marrow hypoplastic MDS/AML, whereas Ct type (C-terminal, truncation, deletion), hyperplastic. Studies in mice and in human cells with transformed muted AML1 genes have shown that pathogenic expression of Ni type AML requires another genetic alteration to promote cell proliferation, and further, that, in Ni and Ct types, progression to AML is dependent on different mechanisms of BMI-1 overexpression for hemopoietic stem cells to proliferate, and of suppression of differentiation of blast cells, respectively. Thus molecular pathogenesis of MDS/AML, refractory hitherto, is being close to elucidation for aiming at its treatment. (K.T)

  5. The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.

    OpenAIRE

    Zent, C S; Mathieu, C.; Claxton, D F; Zhang, D E; Tenen, D.G.; Rowley, J D; Nucifora, G

    1996-01-01

    The (3;21)(q26;q22) translocation associated with treatment-related myelodysplastic syndrome, treatment-related acute myeloid leukemia, and blast crisis of chronic myeloid leukemia results in the expression of the chimeric genes AML1/EAP, AML1/MDS1, and AML1/EVI1. AML1 (CBFA2), which codes for the alpha subunit of the heterodimeric transcription factor CBF, is also involved in the t(8;21), and the gene coding for the beta subunit (CBFB) is involved in the inv(16). These are two of the most co...

  6. Therapy-related AML/MDS after treatment of low-grade B-cell lymphoma

    International Nuclear Information System (INIS)

    Described is the therapy-related AML (acute myelogenetic leukemia)/MDS (myelo-dysplasia syndrome), which is manifested after various treatments of low-grade B-cell lymphoma and has strongly attracted attention because of the markedly improved prognosis due to recent advantages of the therapy for the disease. AML/MDS occurs several years after chemotherapy and/or radiation therapy which cause DNA damage in hematopoietic cells, and the AML/MDS risk is known increased in patients undergone especially with autologous transplantation of those cells. AML/MDS has the feature similar to that caused either by alkylating agent or by topoisomerase-2 inhibitor, and the disease by radiation belong to the former. Yet unclear is the problem whether malignant cells causing the disease after therapy are derived from the remaining cells in the graft or in the body. Although irradiations of total body and total lymphaden as well as chemotherapy are said to be related to AML/MDS and local irradiation does not contribute to its risk, the most important factor for the disease is considered to be the autotransplantation as the recurrence occurs in 50% after it. Thus the treatment history should be taken into consideration for suppressing AML/MDS, for which follow up with consideration for the disease is required particularly after autotransplantation. (R.T.)

  7. Defining AML and MDS second cancer risk dynamics after diagnoses of first cancers treated or not with radiation.

    Science.gov (United States)

    Radivoyevitch, T; Sachs, R K; Gale, R P; Molenaar, R J; Brenner, D J; Hill, B T; Kalaycio, M E; Carraway, H E; Mukherjee, S; Sekeres, M A; Maciejewski, J P

    2016-02-01

    Risks of acute myeloid leukemia (AML) and/or myelodysplastic syndromes (MDS) are known to increase after cancer treatments. Their rise-and-fall dynamics and their associations with radiation have, however, not been fully characterized. To improve risk definition we developed SEERaBomb R software for Surveillance, Epidemiology and End Results second cancer analyses. Resulting high-resolution relative risk (RR) time courses were compared, where possible, to results of A-bomb survivor analyses. We found: (1) persons with prostate cancer receiving radiation therapy have increased RR of AML and MDS that peak in 1.5-2.5 years; (2) persons with non-Hodgkin lymphoma (NHL), lung and breast first cancers have the highest RR for AML and MDS over the next 1-12 years. These increased RR are radiation specific for lung and breast cancer but not for NHL; (3) AML latencies were brief compared to those of A-bomb survivors; and (4) there was a marked excess risk of acute promyelocytic leukemia in persons receiving radiation therapy. Knowing the type of first cancer, if it was treated with radiation, the interval from first cancer diagnosis to developing AML or MDS, and the type of AML, can improve estimates of whether AML or MDS cases developing in this setting are due to background versus other processes. PMID:26460209

  8. Gene expression profiling in MDS and AML: potential and future avenues

    DEFF Research Database (Denmark)

    Theilgaard-Mönch, K; Boultwood, J; Ferrari, S; Giannopoulos, K; Hernandez-Rivas, J M; Kohlmann, A; Morgan, M; Porse, Bo T; Tagliafico, E; Zwaan, C M; Wainscoat, J; Van den Heuvel-Eibrink, M M; Mills, K; Bullinger, L

    2011-01-01

    AML with regard to diagnosis, prediction of clinical outcome, discovery of novel subclasses and identification of novel therapeutic targets and novel drugs. As many challenges remain ahead, we discuss the pitfalls of this technology and its potential including future integrative studies with other......, and even within some cytogenetically well-defined subclasses there is considerable clinical heterogeneity. Recent advances in genomics technologies such as gene expression profiling (GEP) provide powerful tools to further characterize myeloid malignancies at the molecular level, with the goal to...... genomics technologies, which will continue to improve our understanding of malignant transformation in myeloid malignancies and thereby contribute to individualized risk-adapted treatment strategies for MDS and AML patients....

  9. Paclitaxel Induced MDS and AML: A Case Report and Literature Review

    Science.gov (United States)

    Bhatnagar, Udit Bhaskar; Singh, Daulath; Glazyrin, Alexy; Moormeier, Jill

    2016-01-01

    Therapy related acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS) have been classically linked to alkylating agents and topoisomerase inhibitors. They constitute about 1% of all AMLs. There is less evidence on association of taxanes (paclitaxel and docetaxel) with these myeloid neoplasms. We present a case of paclitaxel therapy related acute myelogenous leukemia after treatment of endometrial cancer with a regimen containing paclitaxel and carboplatin. A 63-year-old female underwent surgery followed by a total of 6 cycles of chemotherapy with carboplatin and paclitaxel. Six months after last cycle of chemotherapy, she was diagnosed with myelodysplastic syndrome with refractory anemia and excess blasts. Six weeks later, she had worsening anemia and thrombocytopenia which prompted a bone marrow biopsy which revealed acute myelomonocytic leukemia. A thorough literature review revealed 12 other case reports where taxanes have been implicated in the development of therapy related myeloid neoplasm. Based on the timeline of events in our patient, paclitaxel is the likely culprit in the pathogenesis of this myeloid neoplasm. This rare but significantly grave adverse effect should be kept in consideration when deciding on treatment options for gynecological malignancies. PMID:27057370

  10. Paclitaxel Induced MDS and AML: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Udit Bhaskar Bhatnagar

    2016-01-01

    Full Text Available Therapy related acute myelogenous leukemia (AML and myelodysplastic syndromes (MDS have been classically linked to alkylating agents and topoisomerase inhibitors. They constitute about 1% of all AMLs. There is less evidence on association of taxanes (paclitaxel and docetaxel with these myeloid neoplasms. We present a case of paclitaxel therapy related acute myelogenous leukemia after treatment of endometrial cancer with a regimen containing paclitaxel and carboplatin. A 63-year-old female underwent surgery followed by a total of 6 cycles of chemotherapy with carboplatin and paclitaxel. Six months after last cycle of chemotherapy, she was diagnosed with myelodysplastic syndrome with refractory anemia and excess blasts. Six weeks later, she had worsening anemia and thrombocytopenia which prompted a bone marrow biopsy which revealed acute myelomonocytic leukemia. A thorough literature review revealed 12 other case reports where taxanes have been implicated in the development of therapy related myeloid neoplasm. Based on the timeline of events in our patient, paclitaxel is the likely culprit in the pathogenesis of this myeloid neoplasm. This rare but significantly grave adverse effect should be kept in consideration when deciding on treatment options for gynecological malignancies.

  11. Invasive fungal infections in AML/MDS patients treated with azacitidine: a risk worth considering antifungal prophylaxis?

    Science.gov (United States)

    Pomares, Helena; Arnan, Montserrat; Sánchez-Ortega, Isabel; Sureda, Anna; Duarte, Rafael F

    2016-08-01

    The aim of this study is to analyse the risk of invasive fungal infection (IFI) and the need for antifungal prophylaxis in patients with acute myeloid leukaemia and myelodysplastic syndromes (AML/MDS) treated with azacitidine. We retrospectively analysed the incidence of IFI according to EORTC-MSG criteria in 121 consecutive AML/MDS patients receiving 948 azacitidine courses (median 5, range 1-43) between June 2007 and June 2015. Four cases of IFI (two possible, one probable aspergillosis and one proven candidemia) occurred in this series. The incidence rate of proven/probable IFI was 0.21% per treatment cycle and 1.6% per patient treated for the whole series, and 0.73% per treatment cycle and 4.1% per patient treated in those with severe neutropenia. Two patients died from IFI, leading to an IFI-attributable mortality rate of 1.65% per patient and 0.21% per treatment cycle. The numbers needed to treat with prophylaxis to prevent one case of IFI are 238 azacitidine cycles or 30 patients throughout their whole treatment course, and 137 azacitidine cycles or 24 patients among those with severe neutropenia. AML/MDS patients treated with azacitidine, including those with severe prolonged neutropenia, have a very low risk of IFI which does not justify the use of antifungal prophylaxis. PMID:27027972

  12. Myeloablative radioimmunotherapies in the conditioning of patients with AML, MDS and multiple myeloma prior to stem cell transplantation

    International Nuclear Information System (INIS)

    Aggressive consolidation chemotherapy and hematopoietic stem cell transplantation have improved the prognosis of patients with acute myeloid leukemia (AML), myelodyplastic syndrome (MDS) and multiple myeloma. Nevertheless, only a minor fraction of patients achieve long-term disease-free survival after stem cell transplantation with disease recurrence being the most common cause of treatment failure. In addition, therapy-related effects such as toxicity of chemotherapy and complications of stem cell transplantation increase mortality rates significantly. Myeloablative radioimmunotherapy uses radiolabeled monoclonal antibodies (mAb) with affinity for the hematopoietic marrow. It applies high radiation doses in the bone marrow but spares normal organs. Adding myeloablative radioimmunotherapy to the conditioning schemes of AML, MDS and multiple myeloma before stem cell transplantation allows for the achievement of a pronounced antileukemic/antimyeloma effect for the reduction of relapse rates without significant increase of acute organ toxicity and therapy-related mortality. In order to optimise therapy, a rational design of the nuclide-antibody combination is necessary. 90Y, 188Re and 131I are the most frequently used β--particles. Of these, 90Y is the most qualified nuclide for myeloablation. Backbone stabilised DTPA are ideal chelators to stably conjugate 90Y to antibodies so far. For myeloablative conditioning, anti-CD66-, -45- and -33-mAb are used. The anti-CD66-antibody BW250/183 binds to normal hematopoietic cells but not to leukemic blasts and myeloma cells. The 90Y-2B3M-DTPA-BW250/183 is the most suited radioimmunoconjugate for patients with an infiltration grade of leukemic blasts in the bone marrow 90Y-anti-CD45-mAb YAML568 are 6.4 ± 1.2 (bone marrow), 3.9 ± 1.4 (liver) and 1.1 ± 0.4 (kidneys). CD45 is expressed also on the extramedullar clonogenic myeloma progenitor cell that circulates in the peripheral blood. Thus, the conditioning of patients with

  13. Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q

    DEFF Research Database (Denmark)

    Treppendahl, Marianne Bach; Möllgård, L; Hellström-Lindberg, E;

    2013-01-01

    During recent years mutations in epigenetic modulators have been identified in several human cancers, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)[1]. CXXC5 has been found to be necessary for retinoic acid induced differentiation of myelocytic leukemia cells...

  14. Treatment-related MDS/AML in a patient after treatment for large-cell neuroendocrine lung cancer.

    Science.gov (United States)

    Ansari, Junaid; Ravipati, Hari P; Munker, Reinhold; Cotelingam, James D; Shackelford, Rodney E; Prouty, Leonard A

    2015-11-01

    Secondary leukemia is a common late complication after exposure to cancer therapies such as chemotherapy and radiotherapy. With the increase in the overall survival of cancer patients over the past 3 decades, treatment-related malignant neoplasms have increased in incidence. Secondary leukemias due to breast cancer and Hodgkin lymphoma have been studied in detail, but to our knowledge only a few case studies have reported secondary leukemias with previous lung cancer.¹⁻⁴ Lung cancer is the leading cause of cancer death in the United States.⁵ Since the overall survival (OS) as well as the progression-free survival (PFS) of lung cancer has improved, secondary malignancies, which are usually aggressive and have a poor prognosis, have become a common occurrence among survivors. The use of concurrent chemo-radiotherapy could increase the risk for secondary cancers. Here we report the case of a patient who developed treatment-related acute myelogenous leukemia (t-AML) with a likely prior myelodysplasia (t-MDS) after receiving combined chemo-radiotherapy for lung cancer. PMID:26863022

  15. Reduced Intensity Hematopoietic-cell Transplantation in Older Patients with AML/MDS: Umbilical Cord Blood is a Feasible Option for Patients without HLA-matched Sibling Donors

    OpenAIRE

    Majhail, Navneet S; Brunstein, Claudio G.; Shanley, Ryan; Sandhu, Karamjeet; McClune, Brian; Oran, Betul; Erica D Warlick; Wagner, John E.; Weisdorf, Daniel J.

    2011-01-01

    Umbilical cord blood (UCB) has increased access to hematopoietic-cell transplantation (HCT) for patients without HLA-matched sibling donors (MSD). We compared outcomes of HCT using MSD (N=38) or UCB (N=60) among older patients (age ≥55 years) with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). All patients received a reduced intensity regimen consisting of cyclophosphamide, fludarabine and 200 cGy total body irradiation. Median age at HCT was 63 years for MSD and 61 years fo...

  16. NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).

    Science.gov (United States)

    Schneider, Friederike; Hoster, Eva; Unterhalt, Michael; Schneider, Stephanie; Dufour, Annika; Benthaus, Tobias; Mellert, Gudrun; Zellmeier, Evelin; Bohlander, Stefan K; Feuring-Buske, Michaela; Buske, Christian; Braess, Jan; Fritsch, Susanne; Heinecke, Achim; Sauerland, Maria C; Berdel, Wolfgang E; Buechner, Thomas; Woermann, Bernhard J; Hiddemann, Wolfgang; Spiekermann, Karsten

    2009-05-21

    Mutations in the NPM1 gene represent the most frequent genetic alterations in patients with acute myeloid leukemia (AML) and are associated with a favorable outcome. In 690 normal karyotype (NK) AML patients the complete remission rates (CRs) and the percentage of patients with adequate in vivo blast cell reduction 1 week after the end of the first induction cycle were significantly higher in NPM1(+) (75% and 80%, respectively) than in NPM1(-) (57% and 57%, respectively) patients, but were unaffected by the FLT3-ITD status. Multivariate analyses revealed the presence of a NPM1 mutation as an independent positive prognostic factor for the achievement of an adequate day-16 blast clearance and a CR. In conclusion, NPM1(+) blast cells show a high in vivo sensitivity toward induction chemotherapy irrespective of the FLT3-ITD mutation status. These findings provide insight into the pathophysiology and help to understand the favorable clinical outcome of patients with NPM1(+) AML. PMID:19279329

  17. TEL-AML1 - Spleißvarianten und sequentielle Untersuchung zum Therapieansprechen von TEL-AML1 positiven ALL-Rezidiven im Kindesalter

    OpenAIRE

    Elbers, Sandra

    2010-01-01

    The translocation t(12;21) which fuses the TEL-gene on chromosome 12 to the AML1-gene on chromosome 21 is the most common genetic anomaly in childhood ALL. TEL-AML1 positive patients are a heterogeneous group with different rates of relapse and the impact of TEL-AML1 on long-term prognosis is still discussed controversially. Two TEL-AML1 transcripts are known which result from different breakpoints in the AML1-gene and from alternative mRNA splicing. In this study, we investigated whether the...

  18. High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk Nuclear Test Site

    International Nuclear Information System (INIS)

    It is known that bone marrow is a sensitive organ to ionizing radiation, and many patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) have been diagnosed in radiation-treated cases and atomic bomb survivors in Hiroshima and Nagasaki. The AML1/RUNX1 gene has been known to be frequently mutated in MDS/AML patients among atomic bomb survivors and radiation therapy-related MDS/AML patients. In this study, we investigated the AML1 mutations in radiation-exposed patients with MDS/AML among the residents near the Semipalatinsk Nuclear Test Site (SNTS), where the risk of solid cancers and leukemias was increased due to the radiation effects. AML1 mutations were identified in 7 (39%) of 18 radiation-exposed MDS/AML patients. In contrast, no AML1 mutation was found in 13 unexposed MDS/AML cases. The frequency of AML1 mutations in radiation-exposed patients with MDS/AML was significantly higher compared with unexposed patients (p<0.05).We also found a significant correlation between individual estimated doses and AML1 mutations (p<0.05). Considering these results, AML1 point mutations might be a useful biomarker that differentiates radio-induced MDS/AML from spontaneous MDS/AML. (author)

  19. AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk Nuclear Test Site

    International Nuclear Information System (INIS)

    It is known that bone marrow is a sensitive organ to ionizing radiation, and many patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) have been diagnosed in radiation-treated cases and atomic bomb survivors in Hiroshima and Nagasaki. The AML1/RUNX1 gene has been known to be frequently mutated in MDS/AML patients among atomic bomb survivors and radiation therapy-related MDS/AML patients. In this study, the analyze of gene mutations in the patients with hematological malignancies, living near the Semipalatinsk Nuclear Test Site (SNTS), where the risk of solid cancers and leukemias were increased. The majority of AML1 mutations identified in these MDS/AML were localized in the amino (N)-terminal region. By contrast, AML1 mutations in sporadic MDS/AML were distributed throughout the gene. AML1 mutations were identified in 9 (38%) of 24 radiation-exposed MDS/AML patients. In contrast, no AML1 mutation was found in unexposed MDS/AML cases. All mutations were in (N)-terminal region, but not in (C)-terminal region. The frequency of AML1 mutations in radiation-exposed patients with MDS/AML was significantly higher compared with unexposed patients. These results suggested that radiation might contribute to the development of MDS/AML through AML1 mutations among the residents near the SNTS, as well as among A-bomb survivors.

  20. AML Handboek

    OpenAIRE

    Wiechen CMAG van; CIM

    1995-01-01

    Het AML handboek is ontstaan uit een behoefte aan standaardisering binnen het Rijksinstituut voor Volksgezondheid en Milieu. Het biedt AML-programmeurs de algemene standaard waaraan RIVM-brede applicaties, geschreven in de Arc Macro Language, moeten voldoen. Bepaalde elementen van een AML bleken goed te standaardiseren, zoals de lay-out en de opbouw van het bestand. Ook zaken als taalgebruik, tekst, gebruik van directieven, functies en variabelen komen aan de orde, voor zowel AML's als M...

  1. Myelodysplastic changes mimicking MDS following treatment for osteosarcoma

    DEFF Research Database (Denmark)

    Løhmann, Ditte

    -MDS/AML) is a feared long-term complication of paediatric cancer including osteosarcoma. Few develop t-MDS/AML, but it is not known how many have significant haematological changes after finishing treatment for osteosarcoma. In this study we reviewed biochemistry from a consecutive series of children for up....... In one case MDS (refractory anaemia with excess blasts) with monosomy 7 was found and a hematopoietic stem cell transplant was performed. In the other case MDS without excess of blasts was found and a spontaneous normalization of the biochemistry occurred. In conclusion in our study most patients......Myelodysplastic changes mimicking MDS following treatment for osteosarcoma Ditte Juel Adolfsen Løhmann, Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark Authors: Ditte Juel Adolfsen Løhmann and Henrik Hasle. Therapy-related myelodysplastic syndrome/acute myeloid leukaemia (t...

  2. AML1 gene rearrangements and mutations in radiation-associated acute myeloid leukemia and myelodysplastic syndromes

    International Nuclear Information System (INIS)

    Several studies suggested a causal link between AML1 gene rearrangements and both radiation-induced acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). Fifty-three AML samples were analyzed for the presence of AML1 abnormalities using fluorescent in-situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR). Of these patients, 24 had experienced radiation exposure due to the Chernobyl accident, and 29 were non-irradiated spontaneous AML cases and served as controls. AML1/ETO translocations were found in 9 of 29 spontaneous AML but only in 1 of 24 radiation-associated AML cases. This difference between translocation frequencies is statistically significant in the age-unstratified cohorts (p=0.015). Following age stratification, the difference becomes less pronounced but remains on borderline significance (p=0.053). AML1 mutation status was assessed in 5 clean-up workers at Chemobyl NPP with MDS, or AML following MDS, by direct sequencing of genomic DNA from the coding region (exon 3 through 8). In one patient who developed MDS following an acute radiation syndrome, a hexanucleotide duplication of CGGCAT in exon 8 was found, inserted after base position 1502. Our results suggest that AML1 gene translocations are infrequent in radiation-induced leukemogenesis but are consistent with the idea that radiation may contribute to the development of MDS through AML1 gene mutation. (author)

  3. The applicability of the WHO classification in paediatric AML. A NOPHO-AML study

    DEFF Research Database (Denmark)

    Sandahl, Julie D; Kjeldsen, Eigil; Abrahamsson, Jonas; Ha, Shau-Yin; Heldrup, Jesper; Jahnukainen, Kirsi; Jónsson, Ólafur G; Lausen, Birgitte; Palle, Josefine; Zeller, Bernward; Forestier, Erik; Hasle, Henrik

    2015-01-01

    population-based paediatric acute myeloid leukaemia (AML) cohort. We included children diagnosed with de novo AML, 0-18 years of age from the Nordic countries and Hong Kong from 1993 to 2012. Data were retrieved from the Nordic Society for Paediatric Haematology and Oncology AML database and patients...... classified according to the WHO 2008 classification. A successful karyotype was available in 97% of the cases. AML with recurrent genetic abnormalities were present in 262 (41%) and 94 (15%) were classified as AML with myelodysplasia-related changes (AML-MDS). WHO classifies patients with monosomy 7 and del......(7q) into one group. We found that -7 (n = 14) had significantly poorer outcome than del(7q) (n = 11); 5-year event-free survival 26% vs. 67%, (P = 0·02), and 5-year overall survival 51% vs. 90%, (P = 0·04). The largest group was the highly heterogeneous AML not otherwise specified (NOS) (n = 280...

  4. Atmospheric Measurements Laboratory (AML)

    Data.gov (United States)

    Federal Laboratory Consortium — The Atmospheric Measurements Laboratory (AML) is one of the nation's leading research facilities for understanding aerosols, clouds, and their interactions. The AML...

  5. Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML

    DEFF Research Database (Denmark)

    Preiss, Birgitte S; Bergman, Olav J; Friis, Lone S; Sørensen, Anne; Frederiksen, Michael; Gadeberg, Ole V; Mourits-Andersen, Torben; Østergaard, Birthe; Kerndrup, Gitte B

    2010-01-01

    by treatment with chemotherapy and/or irradiation (t-AML). Cytogenetic analysis was carried out in 93%, of which 61% had clonal chromosome aberrations. MDS-AML correlated to a normal karyotype (P <0.001). t-AML correlated to abnormal clones with numerical and structural aberrations (P = 0.03), five...... or more unrelated aberrations (P = 0.03), marker chromosomes (P = 0.006), abnormal mitoses only (P = 0.01), female sex (P <0.001), and -7 (P = 0.006). Centromeric breakage correlated to a complex karyotype (P = 0.01). The frequencies of aberrations in s-AML patients were compared with an age......-matched group of de novo AML patients diagnosed in the same area and period. In this comparison, s-AML only correlated to -7 (P = 0.02). In 42 patients, we found that MDS patients with an abnormal karyotype were more likely to show cytogenetic evolution during progression to AML than MDS patients with a normal...

  6. Aplastic Anemia & MDS International Foundation

    Science.gov (United States)

    ... Netherlands Antilles New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Northern Mariana Islands North Korea ... Gifts Corporate Sponsorship Invest in Research Diseases Aplastic Anemia Causes Symptoms Diagnosis Types Treatments Myelodysplastic Syndromes (MDS) ...

  7. RUNX1/AML1 point mutations take part in the pathogenesis of radiation-and therapy-related myeloid neoplasms

    International Nuclear Information System (INIS)

    High frequency of myelodysplastic syndrome (MDS) has been reported in Hiroshima A-bomb exposed survivors, in resident around Semipalatinsk Nuclear Laboratory and in exposed people by Chernobyl Nuclear Power Station Accident. MDS/acute myeloid leukemia (AML) is thought to be caused by mutation of runt-related transcription factor 1 (RUNX1) gene after a long time post exposure to relatively low dose radiation. In this study, participation of RUNX1/AML1 point mutations was examined in pathogenesis of the title neoplasms experienced in authors' facility. Subjects were 18/417 cases in whom myeloproliferative neoplasms (MPN) had switched to MDS or AML in the follow-up period of 1-25 years, and 11/124 cases in whom t-MN (therapy-related myeloid neoplasms) had developed during the remission of acute promyelocytic leukemia (APL) in the 1-9.7 years follow up. Point mutations were analyzed by PCR-single strand conformation polymorphism (PCR-SSCP) followed by base sequencing. In the former cases above, RUNX1 point mutation was found in 5/18 cases and in the latter, 4/11. When patients with persistent decrease of blood cells post therapy of APL were followed up for mutation, their RUNX1 point mutation was detected before they were diagnosed to be morbid of MDS/AML. The point mutation was thus a biomarker of myelo-hematogenic cancer, and was thought useful for early diagnosis of MDS and AML. (T.T.)

  8. The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.

    Science.gov (United States)

    Zhou, Liang; Chen, Shuang; Zhang, Yu; Kmieciak, Maciej; Leng, Yun; Li, Lihong; Lin, Hui; Rizzo, Kathryn A; Dumur, Catherine I; Ferreira-Gonzalez, Andrea; Rahmani, Mohamed; Povirk, Lawrence; Chalasani, Sri; Berger, Allison J; Dai, Yun; Grant, Steven

    2016-05-01

    Two classes of novel agents, NEDD8-activating enzyme (NAE) and histone deacetylase (HDAC) inhibitors, have shown single-agent activity in acute myelogenous leukemia (AML)/myelodysplastic syndrome (MDS). Here we examined mechanisms underlying interactions between the NAE inhibitor pevonedistat (MLN4924) and the approved HDAC inhibitor belinostat in AML/MDS cells. MLN4924/belinostat coadministration synergistically induced AML cell apoptosis with or without p53 deficiency or FLT3-internal tandem duplication (ITD), whereas p53 short hairpin RNA (shRNA) knockdown or enforced FLT3-ITD expression significantly sensitized cells to the regimen. MLN4924 blocked belinostat-induced antiapoptotic gene expression through nuclear factor-κB inactivation. Each agent upregulated Bim, and Bim knockdown significantly attenuated apoptosis. Microarrays revealed distinct DNA damage response (DDR) genetic profiles between individual vs combined MLN4924/belinostat exposure. Whereas belinostat abrogated the MLN4924-activated intra-S checkpoint through Chk1 and Wee1 inhibition/downregulation, cotreatment downregulated multiple homologous recombination and nonhomologous end-joining repair proteins, triggering robust double-stranded breaks, chromatin pulverization, and apoptosis. Consistently, Chk1 or Wee1 shRNA knockdown significantly sensitized AML cells to MLN4924. MLN4924/belinostat displayed activity against primary AML or MDS cells, including those carrying next-generation sequencing-defined poor-prognostic cancer hotspot mutations, and CD34(+)/CD38(-)/CD123(+) populations, but not normal CD34(+) progenitors. Finally, combined treatment markedly reduced tumor burden and significantly prolonged animal survival (P < .0001) in AML xenograft models with negligible toxicity, accompanied by pharmacodynamic effects observed in vitro. Collectively, these findings argue that MLN4924 and belinostat interact synergistically by reciprocally disabling the DDR in AML/MDS cells. This strategy

  9. Access/AML

    Data.gov (United States)

    Department of Transportation — The AccessAML is a web-based internet single application designed to reduce the vulnerability associated with several accounts assinged to a single users. This is a...

  10. MDS 3.0 Frequency Report

    Data.gov (United States)

    U.S. Department of Health & Human Services — The MDS 3.0 Frequency Report summarizes information for active residents currently in nursing homes. The source of these counts is the residents MDS assessment...

  11. Reasons for treating secondary AML as de novo AML

    DEFF Research Database (Denmark)

    Ostgård, Lene Sofie Granfeldt; Kjeldsen, Eigil; Holm, Mette Skov;

    2010-01-01

    77 cases (49%), CMPD (chronic myeloproliferative disorder) in 43 cases (27%) and was therapy-related AML (t-AML) in 37 cases (24%). Median age at diagnosis of AML was 69 yr in secondary cases when compared to 66 yr in de novo cases (P = 0.006). In univariate analyses, secondary AML was associated...... with an inferior complete remission (CR) rate (P = 0.008) and poorer overall survival (OS, P = 0.003) whereas in complete remitters, disease-free survival (DFS) of secondary cases was equal to that of de novo cases. Interestingly, in all further analyses of CR-rates, OS and DFS, when correcting for the...

  12. Acute myelogenous leukemia (AML) - children

    Science.gov (United States)

    Acute myelogenous leukemia - children; AML; Acute myeloid leukemia - children; Acute granulocytic leukemia - children; Acute myeloblastic leukemia - children; Acute non-lymphocytic leukemia (ANLL) - children

  13. Clofarabine±Fludarabine with Once Daily IV Busulfan as Pretransplant Conditioning Therapy for Advanced Myeloid Leukemia and MDS

    OpenAIRE

    Andersson, Borje S.; Valdez, Benigno C.; Lima, Marcos; Wang, Xuemei; Thall, Peter F.; Worth, Laura L.; Popat, Uday; Madden, Timothy; Hosing, Chitra; Alousi, Amin; Rondon, Gabriela; Kebriaei, Partow; Elizabeth J. Shpall; Jones, Roy B.; Champlin, Richard E.

    2010-01-01

    While a combination of IV busulfan (Bu) and fludarabine (Flu) is a safe, reduced-toxicity conditioning program for AML/MDS, recurrent leukemia post transplantation remains a problem. To enhance the conditioning regimen’s antileukemic effect we decided to supplant Flu with clofarabine (Clo), and assayed the interactions of these nucleoside analogs alone and in combination with Busulfan (Bu) in Bu-resistant human cell lines in vitro. We found pronounced synergy between each nucleoside and the a...

  14. Long Term Care Minimum Data Set (MDS)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Long-Term Care Minimum Data Set (MDS) is a standardized, primary screening and assessment tool of health status that forms the foundation of the comprehensive...

  15. The CloudMdsQL Multistore System

    OpenAIRE

    Kolev, Boyan; Bondiombouy, Carlyna; Valduriez, Patrick; Jiménez-Peris, Ricardo; Pau, Raquel; Pereira, José

    2016-01-01

    The blooming of different cloud data management infrastructures has turned multistore systems to a major topic in the nowadays cloud landscape. In this demonstration, we present a Cloud Multidatastore Query Language (CloudMdsQL), and its query engine. CloudMdsQL is a functional SQL-like language, capable of querying multiple heterogeneous data stores (relational and NoSQL) within a single query that may contain embedded invocations to each data store's native query interface. The major innova...

  16. Herunterregulation des Proto-Onkogens c-Jun durch das CCAAT/Enhancer bindende Protein alpha in der Myelopoese und in der akuten myeloischen Leukämie (AML)

    OpenAIRE

    Treiber, Nicolai

    2004-01-01

    Verschiedene Transkriptionsfaktoren spielen eine Rolle in der Entwicklung myeloischer Zellen. c-Jun gehört zur Familie der AP-1 Transkriptionsfaktoren und ist ein Koaktivator des Transkriptionsfaktors PU.1, der für die Differenzierung zu Monozyten wichtig ist. C/EBPa ist ein an den CCAAT-Enhancer bindender Transkriptionsfaktor. Wird C/EBPa exprimiert, differenzieren sich bipotente myeloische Zellen zu neutrophilen Granulozyten. Die durch den Induktor TPA hervorgerufene Differenzierung zu Mono...

  17. Lessons from the atomic bomb about secondary MDS.

    Science.gov (United States)

    Hata, Tomoko; Imanishi, Daisuke; Miyazaki, Yasushi

    2014-12-01

    Myelodysplastic syndromes (MDSs) is a hematological neoplasm defined by ineffective hematopoiesis, dysplasia of hematopoietic cells, and risk of progression to acute leukemia. MDS occurs as de novo or secondary, and chemoradiotherapy for cancers is thought to increase the risk of MDS among patients. Recently, an epidemiological study for MDS among A-bomb survivors was performed, and it clearly demonstrated that the exposure to external radiation significantly increased the risk of MDS. Precise epidemiological data among survivors have revealed important clinical factors related to the risk of leukemias. In this review, by comparing data for secondary MDS and leukemia/MDS among survivors, several factors which would affect the risk of MDS, especially secondary MDS, are discussed. PMID:25240475

  18. Nearly MDS expander codes with reduced alphabet size

    OpenAIRE

    Armand, Marc A.; Zhang, Jianwen

    2007-01-01

    Recently, Roth and Skachek proposed two methods for constructing nearly maximum-distance separable (MDS) expander codes. We show that through the simple modification of using mixed-alphabet codes derived from MDS codes as constituent codes in their code designs, one can obtain nearly MDS codes of significantly smaller alphabet size, albeit at the expense of a (very slight) reduction in code rate.

  19. Chronic GVHD induced GVL effect after unmanipulated haploidentical hematopoietic SCT for AML and myelodysplastic syndrome.

    Science.gov (United States)

    Mo, X-D; Xu, L-P; Zhang, X-H; Liu, D-H; Wang, Y; Chen, H; Yan, C-H; Chen, Y-H; Han, W; Wang, F-R; Wang, J-Z; Liu, K-Y; Huang, X-J

    2015-01-01

    The aim of this study was to investigate the impact of occurrence of chronic GVHD (cGVHD) and its severity on transplantation outcomes in a consecutive cohort of AML and myelodysplastic syndrome (MDS) patients who received unmanipulated haploidentical hematopoietic SCT (haplo-HSCT; n=324). The cumulative incidence of relapse was significantly decreased in patients with cGVHD compared with the non-cGVHD group (1 year: 3.2% vs 11.9%, P=0.002; 3 years: 6.0% vs 16.3%, P=0.002), particularly in those with mild cGVHD. The cumulative incidence of non-relapse mortality was comparable between patients with and without cGVHD. The probabilities of disease-free survival (DFS) were significantly better in patients with cGVHD than in those in the non-cGVHD group (1 year: 90.5% vs 78.5%, P=0.002; 3 years: 86.5% vs 71.5%, PGVL effect in patients with AML and MDS receiving unmanipulated haplo-HSCT; however, only mild or moderate cGVHD was associated with a lower risk of relapse translating into improved DFS. PMID:25387095

  20. On the Upper Bounds of MDS Codes

    OpenAIRE

    Yang, Jiansheng; Zhang, Yunying

    2009-01-01

    Let $M_{q}(k)$ be the maximum length of MDS codes with parameters $q,k$. In this paper, the properties of $M_{q}(k)$ are studied, and some new upper bounds of $M_{q}(k)$ are obtained. Especially we obtain that $M_{q}(q-1)\\leq q+2(q\\equiv4(mod 6)), M_{q}(q-2)\\leq q+1(q\\equiv4(mod 6)), M_{q}(k)\\leq q+k-3 (q=36(5s+1), s\\in N$ and $ k=6,7).

  1. Patients with Fanconi Anemia and AML have Different Cytogenetic Clones than de novo Cases of AML

    OpenAIRE

    Rochowski, Andrzej; Olson, Susan B; Alonzo, Todd A; Gerbing, Robert B.; Lange, Beverly J.; Alter, Blanche P.

    2012-01-01

    Specific cytogenetic clones might distinguish patients with unrecognized Fanconi anemia (FA) who present with acute myeloid leukemia (AML) from those with sporadic AML. Cytogenetic reports in literature cases of FA and AML were compared with de novo cases enrolled on CCG-2961. Gain of 1q, gain of 3q, monosomy 7, deleted 7q, gain of 13q, and deleted 20q were more frequent in FA AML; t(8;21), trisomy 8, t(9;11), t(6;9) and inversion 16 were exclusive to de novo AML cases. Observation of the FA ...

  2. How to treat MDS without stem cell transplantation.

    Science.gov (United States)

    Gattermann, Norbert

    2010-01-01

    Although allogeneic hematopoietic cell transplantation (HCT) is the only proven curative treatment for myelodysplastic syndromes (MDS), it is only used to treat a minority of MDS patients. The majority of patients are too old or suffer from comorbidities rendering allogeneic HCT too risky. Alternative treatment strategies for patients with higher risk MDS try to alter the natural course of disease by preventing or delaying leukemic transformation. In patients with lower risk MDS, treatment is mainly focused on maintaining or improving the quality of life. PMID:19857591

  3. AML1/ETO oncoprotein is directed to AML1 binding regions and co-Localizes with AML1 and HEB on its targets

    OpenAIRE

    Gardini, A.; M. Cesaroni; Luzi, L.; A.J. Okumura; J.R. Biggs; S.P.Minardi; E. Venturini; Zhang, D E; Pelicci, P G; Alcalay, M

    2008-01-01

    A reciprocal translocation involving chromosomes 8 and 21 generates the AML1/ETO oncogenic transcription factor that initiates acute myeloid leukemia by recruiting co-repressor complexes to DNA. AML1/ETO interferes with the function of its wild-type counterpart, AML1, by directly targeting AML1 binding sites. However, transcriptional regulation determined by AML1/ETO probably relies on a more complex network, since the fusion protein has been shown to interact with a number of other transcrip...

  4. The drift-flux correlation package MDS

    International Nuclear Information System (INIS)

    Based on the SONNENBURG drift-flux correlation, developed at GRS/Garching (Germany), a comprehensive drift-flux correlation package (MDS) has been established. Its aim is to support thermal-hydraulic mixture-fluid models, models being used for the simulation of the steady state and transient behaviour of characteristic thermal-hydraulic parameters of single- or two-phase fluids flowing along coolant channels of different types (being, e.g., parts of NPP-s, steam generators etc.). The characteristic properties of this package with respect to the behaviour at co- and counter-current flow, its inverse solutions needed for steady state simulations, its behaviour when approaching the lower or upper boundary of a two-phase region, its verification and behaviour with respect to other correlations will be discussed. An adequate driver code, MDSDRI, has been established too, allowing to test the package very thoroughly out of the complex thermal-hydraulic codes. (author)

  5. AML Guide: Information for Patients and Caregivers

    Science.gov (United States)

    ... to have children later on) {{ Bone problems {{ Heart problems {{ Learning problems. Adults who are treated for AML may have {{ Fertility problems {{ Thyroid problems {{ Problems ... child’s learning skills should be checked. Want more information? You ...

  6. A case of Ph1 positive AML

    International Nuclear Information System (INIS)

    An 83-year-old woman with AML was exposed to A-bomb at 1,700 m from the hypocenter in Hiroshima at the age of 44 years. In this patient, the lack of splenomegaly and basophilia, which are characteristic of Ph1 positive AML, were observed. She died one month after the occurrence of the disease. The relevant literature was reviewed. (Namekawa, K.)

  7. Iron overload in MDS-pathophysiology, diagnosis, and complications.

    Science.gov (United States)

    Gattermann, Norbert; Rachmilewitz, Eliezer A

    2011-01-01

    Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among iron accumulation, clinical complications, and decreased likelihood of survival in MDS patients. Here, we discuss our current understanding of the effects of transfusion dependency and iron overload in MDS, indicate our knowledge gaps, and suggest that particular emphasis should be placed on further characterizing the role of redox-active forms of labile iron, which may be as important as the total iron burden. PMID:20938663

  8. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML

    OpenAIRE

    Pearce, Daniel J.; Taussig, David; Zibara, Kazem; Smith, Lan-Lan; Ridler, Christopher M.; Preudhomme, Claude; Young, Bryan D.; Rohatiner, Ama Z; Lister, T. Andrew; Bonnet, Dominique

    2006-01-01

    The nonobese diabetic/severe combined immunodeficient (NOD/SCID) assay is the current model for assessment of human normal and leukemic stem cells. We explored why 51% of 59 acute myeloid leukemia (AML) patients were unable to initiate leukemia in NOD/SCID mice. Increasing the cell dose, using more permissive recipients, and alternative tissue sources did not cause AML engraftment in most previously nonengrafting AML samples. Homing of AML cells to the marrow was the same between engrafters a...

  9. MDS 2.0 Public Quality Indicator and Resident Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Minimum Data Set (MDS) is part of the federally mandated process for clinical assessment of all residents in Medicare or Medicaid certified nursing homes. This...

  10. Resident Assessment Instrument/Minimum Data Set (RAI/MDS)

    Data.gov (United States)

    Department of Veterans Affairs — The Resident Assessment Instrument/Minimum Data Set (RAI/MDS) is a comprehensive assessment and care planning process used by the nursing home industry since 1990...

  11. Impact on survival of different treatments for myelodysplastic syndromes (MDS).

    Science.gov (United States)

    Nachtkamp, Kathrin; Kündgen, Andrea; Strupp, Corinna; Giagounidis, Aristoteles; Kobbe, Guido; Gattermann, Norbert; Haas, Rainer; Germing, Ulrich

    2009-08-01

    Therapies for myelodysplastic syndromes (MDS) often achieve hematological responses but their impact on overall survival has generally not been evaluated. The Duesseldorf MDS Registry allowed us to perform matched-pair analyses to assess a possible survival benefit of treatment with thalidomide, valproic acid, low-dose Ara-C, antithymocyte globulin (ATG), induction chemotherapy, or allogeneic stem cell transplantation (allo-SCT). For all treatment modalities, lengthening of survival was restricted to certain subgroups of patients. With the exception of allo-SCT, MDS treatment was generally palliative. Recently, epigenetic treatment with demethylating agents proved to be the first therapy that can significantly prolong survival in patients with higher-risk MDS. PMID:19185917

  12. An improved resource management model based on MDS

    Science.gov (United States)

    Yuan, Man; Sun, Changying; Li, Pengfei; Sun, Yongdong; He, Rui

    2005-11-01

    GRID technology provides a kind of convenient method for managing GRID resources. This service is so-called monitoring, discovering service. This method is proposed by Globus Alliance, in this GRID environment, all kinds of resources, such as computational resources, storage resources and other resources can be organized by MDS specifications. However, this MDS is a theory framework, particularly, in a small world intranet, in the case of limit of resources, the MDS has its own limitation. Based on MDS, an improved light method for managing corporation computational resources and storage resources is proposed in intranet(IMDS). Firstly, in MDS, all kinds of resource description information is stored in LDAP, it is well known although LDAP is a light directory access protocol, in practice, programmers rarely master how to access and store resource information into LDAP store, in such way, it limits MDS to be used. So, in intranet, these resources' description information can be stored in RDBMS, programmers and users can access this information by standard SQL. Secondly, in MDS, how to monitor all kinds of resources in GRID is not transparent for programmers and users. In such way, it limits its application scope, in general, resource monitoring method base on SNMP is widely employed in intranet, therefore, a kind of resource monitoring method based on SNMP is integrated into MDS. Finally, all kinds of resources in the intranet can be described by XML, and all kinds of resources' description information is stored in RDBMS, such as MySql, and retrieved by standard SQL, dynamic information for all kinds of resources can be sent to resource storage by SNMP, A prototype resource description, monitoring is designed and implemented in intranet.

  13. Iron overload in MDS?pathophysiology, diagnosis, and complications

    OpenAIRE

    Gattermann, Norbert; Rachmilewitz, Eliezer A

    2010-01-01

    Abstract Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among iron accumulation, clinical complications, and decreased likelihood of survival in MDS patients. Here, we discuss our current understanding of the effects of transfusion dependenc...

  14. Rational Combinations of Targeted Agents in AML

    Directory of Open Access Journals (Sweden)

    Prithviraj Bose

    2015-04-01

    Full Text Available Despite modest improvements in survival over the last several decades, the treatment of AML continues to present a formidable challenge. Most patients are elderly, and these individuals, as well as those with secondary, therapy-related, or relapsed/refractory AML, are particularly difficult to treat, owing to both aggressive disease biology and the high toxicity of current chemotherapeutic regimens. It has become increasingly apparent in recent years that coordinated interruption of cooperative survival signaling pathways in malignant cells is necessary for optimal therapeutic results. The modest efficacy of monotherapy with both cytotoxic and targeted agents in AML testifies to this. As the complex biology of AML continues to be elucidated, many “synthetic lethal” strategies involving rational combinations of targeted agents have been developed. Unfortunately, relatively few of these have been tested clinically, although there is growing interest in this area. In this article, the preclinical and, where available, clinical data on some of the most promising rational combinations of targeted agents in AML are summarized. While new molecules should continue to be combined with conventional genotoxic drugs of proven efficacy, there is perhaps a need to rethink traditional philosophies of clinical trial development and regulatory approval with a focus on mechanism-based, synergistic strategies.

  15. Prevalence, clinical characteristics and prognosis of GATA2-related myelodysplastic syndromes (MDS) in children and adolescents

    DEFF Research Database (Denmark)

    Wlodarski, Marcin W; Hirabayashi, Shinsuke; Pastor, Victor; Starý, Jan; Hasle, Henrik; Masetti, Riccardo; Dworzak, Michael; Schmugge, Markus; van den Heuvel-Eibrink, Marry; Ussowicz, Marek; De Moerloose, Barbara; Catala, Albert; Smith, Owen P; Sedlacek, Petr; Lankester, Arjan C; Zecca, Marco; Bordon, Victoria; Matthes-Martin, Susanne; Abrahamsson, Jonas; Kühl, Jörn Sven; Sykora, Karl-Walter; Albert, Michael H; Przychodzien, Bartlomiej; Maciejewski, Jaroslaw; Schwarz, Stephan; Göhring, Gudrun; Schlegelberger, Brigitte; Cseh, Annámaria; Noellke, Peter; Yoshimi, Ayami; Locatelli, Franco; Baumann, Irith; Strahm, Brigitte; Niemeyer, Charlotte M

    2015-01-01

    MDS in Childhood (EWOG-MDS) conducted in Germany over a period of 15 years. Germline GATA2 mutations accounted for 15% of advanced and 7% of all primary MDS cases, but were absent in children with MDS secondary to therapy or acquired aplastic anemia. Mutation carriers were older at diagnosis and more...

  16. Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients

    DEFF Research Database (Denmark)

    Ørskov, A. D.; Treppendahl, M. B.; Skovbo, A.;

    2015-01-01

    receptor PD-1 is regulated by DNA methylation. In 12 of 27 patients (44%) PD-1 promoter demethylation was observed in sorted peripheral blood T cells isolated over consecutive cycles of treatment with 5-azacytidine (5-aza). The PD-1 promoter demethylation correlated with an increase in PD-1 expression...

  17. From Stata to aML

    OpenAIRE

    2013-01-01

    This presentation explains how to exploit Stata to run multilevel multiprocess regressions with aML (software downloadable for free from applied-ml.com). I show how a single do-file can prepare the dataset, write the control files, input the starting values, and run the regressions without the need to manually open the aML’s Command Prompt window. In this sense, Stata helps to avoid the difficulties of running complicated regressions with aML by automatically generating the necessary files,...

  18. Prognostic Factors in Childhood Leukemia (ALL or AML)

    Science.gov (United States)

    ... leukemias Prognostic factors in childhood leukemia (ALL or AML) Certain factors that can affect a child’s outlook ( ... more intensive chemotherapy. Prognostic factors for children with AML Prognostic factors are not quite as important in ...

  19. Acute Myeloid Leukemia (AML) with Erythroid Predominance Exhibits Clinical and Molecular Characteristics that Differ from Other Types of AML

    OpenAIRE

    Zuo, Zhuang; Medeiros, L. Jeffrey; Chen, Zhao; Liu, Dingsheng; Bueso-Ramos, Carlos E.; Luthra, Rajyalakshmi; A.Wang, Sa

    2012-01-01

    The clinical importance of erythroid predominance in bone marrow of patients with acute myeloid leukemia (AML) is controversial. These cases represent a heterogeneous group of diseases that historically have been classified into different categories. We studied 313 AML patients and specifically compared the clinical, cytogenetic, and molecular features of cases of AML with erythroid predominance, arbitrarily defined as ≥50% erythroid precursors, to AML cases without erythroid predominance. We...

  20. Update on MDS therapy: from famine to feast.

    Science.gov (United States)

    Chaudhary, Preeti; Shah, Chirag

    2010-10-01

    Myelodysplastic syndromes (MDS) are acquired hematopoietic stem cell disorders characterized by ineffective hematopoiesis, cellular dysfunction and increased risks of transformation into acute myeloid leukemia. The natural history of the disease remains variable and depend upon multiple prognostic factors at the time of initial diagnosis. The current prognostic models are helpful to determine the outcome of individual patients but they remain imperfect. Earlier, the most frequent treatment given for patients with MDS was supportive with transfusion of blood products and administration of erythropoietic stimulating agents and iron chelation therapy. Now, there is an arsenal of therapies available and the landscape for the treatment of MDS is rapidly evolving. There are several FDA approved therapies available for this disorder that makes this review particularly timely and relevant. PMID:20712577

  1. Monitoring the grid with the Globus Toolkit MDS4

    International Nuclear Information System (INIS)

    The Globus Toolkit Monitoring and Discovery System (MDS4) defines and implements mechanisms for service and resource discovery and monitoring in distributed environments. MDS4 is distinguished from previous similar systems by its extensive use of interfaces and behaviors defined in the WS-Resource Framework and WS-Notification specifications, and by its deep integration into essentially every component of the Globus Toolkit. We describe the MDS4 architecture and the Web service interfaces and behaviors that allow users to discover resources and services, monitor resource and service states, receive updates on current status, and visualize monitoring results. We present two current deployments to provide insights into the functionality that can be achieved via the use of these mechanisms

  2. Pathophysiological and clinical aspects of iron chelation therapy in MDS.

    Science.gov (United States)

    Gattermann, Norbert

    2012-01-01

    The majority of patients with myelodysplastic syndromes (MDS) become transfusion-dependent during the course of disease and may thus develop transfusional iron overload. As a further contributor to iron overload there is increased absorption of dietary iron from the gut, as a consequence of ineffective erythropoiesis. Compared with thalassemia, it is less clear how frequent patients with MDS develop clinical complications of iron overload, and whether the accumulation of iron shortens their survival. This review aims to summarize our current knowledge of the detrimental effects of transfusional iron overload in MDS, point out the risks associated with iron-induced oxidative stress, describe the tools available for diagnosing iron overload, indicate the treatment options with currently available iron chelators, and discuss the measurement of labile plasma iron (LPI) as a tool to monitor the efficacy of iron chelation therapy. PMID:22571702

  3. Hyperdiploidy in Childhood AML Associated with Low Age and AML-M7. A NOPHO-AML Study and Literature Review

    DEFF Research Database (Denmark)

    Sandahl, Julie Damgaard; Abrahamson, Jonas; Heldrup, Jesper; Jahnukainen, Kirsi; Ólafur, G; Lausen, Birgitte; Palle, Josefine; Zeller, Bernward; Forestier, Erik; Kjeldsen, Eigil; Hasle, Henrik

    (AML), however, is a rare cytogenetic finding. It is most often categorized as a complex karyotype, which is considered associated with an unfavorable outcome. The group of complex karyotypes is heterogeneous and the significance of multiple additional chromosomes with or without structural...... abnormalities among the pediatric hyperdiploid AML patients is relatively unknown. Current knowledge in this field is based on small adult series or case reports. In this descriptive study we describe the clinical - and cytogenetic features in childhood hyperdiploid AML with a modal chromosome number at 50 or...... more. We report a series of 29 children from the Nordic Countries diagnosed with high hyperdiploid (50+) AML along with 105 cases identified from the literature. Material and Method: Children age 0–18 years diagnosed with AML and treated according to the NOPHO –AML-93 or 2004 protocols from 1993 to...

  4. Mouse models of human AML accurately predict chemotherapy response

    OpenAIRE

    Zuber, Johannes; Radtke, Ina; Pardee, Timothy S.; Zhao, Zhen; Rappaport, Amy R.; Luo, Weijun; McCurrach, Mila E.; Yang, Miao-Miao; Dolan, M. Eileen; Kogan, Scott C.; Downing, James R.; Lowe, Scott W.

    2009-01-01

    The genetic heterogeneity of cancer influences the trajectory of tumor progression and may underlie clinical variation in therapy response. To model such heterogeneity, we produced genetically and pathologically accurate mouse models of common forms of human acute myeloid leukemia (AML) and developed methods to mimic standard induction chemotherapy and efficiently monitor therapy response. We see that murine AMLs harboring two common human AML genotypes show remarkably diverse responses to co...

  5. Identification of AML1-ETO modulators by chemical genomics

    OpenAIRE

    Corsello, Steven M.; Roti, Giovanni; Ross, Kenneth N.; Chow, Kwan T.; Galinsky, Ilene; DeAngelo, Daniel J.; Stone, Richard M.; Kung, Andrew L.; Golub, Todd R.; Stegmaier, Kimberly

    2009-01-01

    Somatic rearrangements of transcription factors are common abnormalities in the acute leukemias. With rare exception, however, the resultant protein products have remained largely intractable as pharmacologic targets. One example is AML1-ETO, the most common translocation reported in acute myeloid leukemia (AML). To identify AML1-ETO modulators, we screened a small molecule library using a chemical genomic approach. Gene expression signatures were used as surrogates for the expression versus ...

  6. Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

    OpenAIRE

    Zaitseva, Lyubov; Murray, Megan Y; Shafat, Manar S.; Lawes, Matthew J.; MacEwan, David J.; Bowles, Kristian M.; Rushworth, Stuart A.

    2014-01-01

    Pharmacological targeting of BTK using ibrutinib has recently shown encouraging clinical activity in a range of lymphoid malignancies. Recently we reported that ibrutinib inhibits human acute myeloid leukemia (AML) blast proliferation and leukemic cell adhesion to the surrounding bone marrow stroma cells. Here we report that in human AML ibrutinib, in addition, functions to inhibit SDF1/CXCR4-mediated AML migration at concentrations achievable in vivo. It has previously been shown that SDF1/C...

  7. Interaction Mediated by the Putative Tip Regions of MdsA and MdsC in the Formation of a Salmonella-Specific Tripartite Efflux Pump

    OpenAIRE

    Song, Saemee; Hwang, Soonhye; Lee, SeungHwa; Ha, Nam-Chul; Lee, Kangseok

    2014-01-01

    To survive in the presence of a wide range of toxic compounds, gram-negative bacteria expel such compounds via tripartite efflux pumps that span both the inner and outer membranes. The Salmonella-specific MdsAB pump consists of MdsB, a resistance-nodulation-division (RND)-type inner membrane transporter (IMT) that requires the membrane fusion protein (MFP) MdsA, and an outer membrane protein (OMP; MdsC or TolC) to form a tripartite efflux complex. In this study, we investigated the role of th...

  8. Cellular origin of prognostic chromosomal aberrations in AML patients

    DEFF Research Database (Denmark)

    Mora-Jensen, H.; Jendholm, J.; Rapin, N.;

    2015-01-01

    these aberrations occur in normal hematopoietic stem and progenitor cells (HSCs/HPCs) before definitive leukemic transformation through additional acquisition of a few (that is, mostly 1 or 2) leukemia-promoting driver aberrations. NGS studies on sorted bone marrow (BM) populations of AML patients with...... molecular aberrations that were present in the fully transformed committed HPCs together with the prognostic driver aberration. Adding to this vast heterogeneity and complexity of AML genomes and their clonal evolution, a recent study of a murine AML model demonstrated that t(9;11) AML originating from HSCs...

  9. New study reveals relatively few mutations in AML genomes - TCGA

    Science.gov (United States)

    Investigators for The Cancer Genome Atlas (TCGA) Research Network have detailed and broadly classified the genomic alterations that frequently underlie the development of acute myeloid leukemia (AML).

  10. Aberrant splicing and drug resistance in AML.

    Science.gov (United States)

    de Necochea-Campion, Rosalia; Shouse, Geoffrey P; Zhou, Qi; Mirshahidi, Saied; Chen, Chien-Shing

    2016-01-01

    The advent of next-generation sequencing technologies has unveiled a new window into the heterogeneity of acute myeloid leukemia (AML). In particular, recurrent mutations in spliceosome machinery and genome-wide aberrant splicing events have been recognized as a prominent component of this disease. This review will focus on how these factors influence drug resistance through altered splicing of tumor suppressor and oncogenes and dysregulation of the apoptotic signaling network. A better understanding of these factors in disease progression is necessary to design appropriate therapeutic strategies recognizing specific alternatively spliced or mutated oncogenic targets. PMID:27613060

  11. A Non-MDS Erasure Code Scheme For Storage Applications

    CERN Document Server

    Kiani, Abbas

    2011-01-01

    This paper investigates the use of redundancy and self repairing against node failures in distributed storage systems, using various strategies. In replication method, access to one replication node is sufficient to reconstruct a lost node, while in MDS erasure coded systems which are optimal in terms of redundancy-reliability tradeoff, a single node failure is repaired after recovering the entire stored data. Moreover, regenerating codes yield a tradeoff curve between storage capacity and repair bandwidth. The current paper aims at investigating a new storage code. Specifically, we propose a non-MDS (2k, k) code that tolerates any three node failures and more importantly, it is shown using our code a single node failure can be repaired through access to only three nodes.

  12. A Construction of Systematic MDS Codes with Minimum Repair Bandwidth

    CERN Document Server

    Wu, Yunnan

    2009-01-01

    In a distributed storage system based on erasure coding, an important problem is the \\emph{repair problem}: If a node storing a coded piece fails, in order to maintain the same level of reliability, we need to create a new encoded piece and store it at a new node. This paper presents a construction of systematic $(n,k)$-MDS codes for $2k\\le n$ that achieves the minimum repair bandwidth when repairing from $k+1$ nodes.

  13. MDS Nordion - a Canadian Radioisotope success story Science advancing health

    International Nuclear Information System (INIS)

    At MDS Nordion we use nuclear science and technology to advance human life and health through a wide range of applications. We could not do this without the strong partnerships we have formed with the Canadian nuclear power industry. Together, we have developed and applied radioisotope technology in ways that have saved millions of lives around the world. This is a success story of which we all can be proud. It is a success story that we should share with others. As an industry, we are often challenged by activists , who fear and attack anything nuclear and who do not care to understand how vital nuclear energy and nuclear science are to an environmentally sound, economically healthy future. MDS Nordion has not escaped this kind of public scrutiny, but much of this criticism is muted by the tremendous contributions we have made to medicine and health care generally. That is why it is so important for you to see MDS Nordion's story as a success story that everyone in the industry has contributed to, in the support they have provided, and in the products or services they supply

  14. Temporal MDS Plots for Analysis of Multivariate Data.

    Science.gov (United States)

    Jäckle, Dominik; Fischer, Fabian; Schreck, Tobias; Keim, Daniel A

    2016-01-01

    Multivariate time series data can be found in many application domains. Examples include data from computer networks, healthcare, social networks, or financial markets. Often, patterns in such data evolve over time among multiple dimensions and are hard to detect. Dimensionality reduction methods such as PCA and MDS allow analysis and visualization of multivariate data, but per se do not provide means to explore multivariate patterns over time. We propose Temporal Multidimensional Scaling (TMDS), a novel visualization technique that computes temporal one-dimensional MDS plots for multivariate data which evolve over time. Using a sliding window approach, MDS is computed for each data window separately, and the results are plotted sequentially along the time axis, taking care of plot alignment. Our TMDS plots enable visual identification of patterns based on multidimensional similarity of the data evolving over time. We demonstrate the usefulness of our approach in the field of network security and show in two case studies how users can iteratively explore the data to identify previously unknown, temporally evolving patterns. PMID:26529694

  15. Advanced Manned Launch System (AMLS) study

    Science.gov (United States)

    Ehrlich, Carl F., Jr.; Potts, Jack; Brown, Jerry; Schell, Ken; Manley, Mary; Chen, Irving; Earhart, Richard; Urrutia, Chuck; Randolph, Ray; Morris, Jim

    1992-01-01

    To assure national leadership in space operations and exploration in the future, NASA must be able to provide cost effective and operationally efficient space transportation. Several NASA studies and the joint NASA/DoD Space Transportation Architecture Studies (STAS) have shown the need for a multi-vehicle space transportation system with designs driven by enhanced operations and low costs. NASA is currently studying an advanced manned launch system (AMLS) approach to transport crew and cargo to the Space Station Freedom. Several single and multiple stage systems from air-breathing to all-rocket concepts are being examined in a series of studies potential replacements for the Space Shuttle launch system in the 2000-2010 time frame. Rockwell International Corporation, under contract to the NASA Langley Research Center, has analyzed a two-stage all-rocket concept to determine whether this class of vehicles is appropriate for the AMLS function. The results of the pre-phase A study are discussed.

  16. RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis

    OpenAIRE

    Yan, Ming; Ahn, Eun-Young; Hiebert, Scott W.; Zhang, Dong-Er

    2009-01-01

    The 8;21 translocation, which involves the gene encoding the RUNX family DNA-binding transcription factor AML1 (RUNX1) on chromosome 21 and the ETO (MTG8) gene on chromosome 8, generates AML1-ETO fusion proteins. Previous analyses have demonstrated that full-length AML1-ETO blocks AML1 function and requires additional mutagenic events to promote leukemia. More recently, we have identified an alternatively spliced form of AML1-ETO, AML1-ETO9a, from t(8;21) acute myeloid leukemia (AML) patient ...

  17. CNS Involvement in AML Patient Treated with 5-Azacytidine

    OpenAIRE

    Diamantina Vasilatou; Sotirios Papageorgiou; Efthymia Bazani; Athina Prasouli; Christina Economopoulou; Christoforos Roumpakis; Petros Karakitsos; George Dimitriadis; Vasiliki Pappa

    2014-01-01

    Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare complication of the disease and is associated with poor prognosis. Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging. Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status.

  18. CNS Involvement in AML Patient Treated with 5-Azacytidine.

    Science.gov (United States)

    Vasilatou, Diamantina; Papageorgiou, Sotirios; Bazani, Efthymia; Prasouli, Athina; Economopoulou, Christina; Roumpakis, Christoforos; Karakitsos, Petros; Dimitriadis, George; Pappa, Vasiliki

    2014-01-01

    Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare complication of the disease and is associated with poor prognosis. Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging. Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status. PMID:25197583

  19. CNS Involvement in AML Patient Treated with 5-Azacytidine

    Science.gov (United States)

    Vasilatou, Diamantina; Papageorgiou, Sotirios; Bazani, Efthymia; Prasouli, Athina; Economopoulou, Christina; Roumpakis, Christoforos; Karakitsos, Petros; Dimitriadis, George; Pappa, Vasiliki

    2014-01-01

    Central nervous system (CNS) involvement in acute myeloid leukemia (AML) is a rare complication of the disease and is associated with poor prognosis. Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging. Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status. PMID:25197583

  20. Nassi-Schneiderman Diagram in HTML Based on AML

    Science.gov (United States)

    Menyhárt, László

    2013-01-01

    In an earlier work I defined an extension of XML called Algorithm Markup Language (AML) for easy and understandable coding in an IDE which supports XML editing (e.g. NetBeans). The AML extension contains annotations and native language (English or Hungarian) tag names used when coding our algorithm. This paper presents a drawing tool with which…

  1. Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice

    OpenAIRE

    Fenske, Timothy S; Pengue, Gina; Mathews, Vikram; Hanson, Piia T.; Hamm, Sarah E.; Riaz, Noor; Graubert, Timothy A

    2004-01-01

    The t(8;21)(q22;q22) translocation, present in 10-15% of acute myeloid leukemia (AML) cases, generates the AML1/ETO fusion protein. To study the role of AML1/ETO in the pathogenesis of AML, we used the Ly6A locus that encodes the well characterized hematopoietic stem cell marker, Sca1, to target expression of AML1/ETO to the hematopoietic stem cell compartment in mice. Whereas germ-line expression of AML1/ETO from the AML1 promoter results in embryonic lethality, heterozygous Sca1+/AML1-ETO i...

  2. The Mice Drawer System Tissue Sharing Program (MDS-TSP)

    Science.gov (United States)

    Biticchi, Roberta; Cancedda, Ranieri; Cilli, Michele; Cotronei, Vittorio; Costa, Delfina; Liu, Yi; Piccardi, Federica; Pignataro, Salvatore; Ruggiu, Alessandra; Tasso, Roberta; Tavella, Sara

    Several organs and apparatus are affected by weightless conditions and in particular by the weightless experienced during space flights. Therefore space missions are good opportunities to investigate in a whole organism the controlling cellular and molecular mechanisms. For this type of studies mice represent an excellent animal model for several reasons: reduced body size, relatively short time needed to reach adulthood, availability of strains with different genetic background and of different transgenic lines, etc. In line with the International Space Station (ISS) development, the Italian Space Agency (ASI) contracted Thales Alenia Space Italia, the largest Italian aerospace industry, to design and build a spaceflight payload for rodent research on ISS, the Mouse Drawer System (MDS -see abstract P. Cipparelli et al.). This payload meets NIH guideline for several physical parameters to maintain 6 animals in good health conditions in a space environment. Given the interest of our laboratory in the microgravity induced skeleton alterations, we focused our attention on transgenic mice over-expressing pleiotrophin (PTN) under the control of the human bone specific osteocalcin promoter. This protein is a heparin-binding cytokine with different functions. PTN is expressed by the cells in an early differentiation stage and is upregulated in tissue injury and wound repair. PTN is specifically involved in bone formation, neurite outgrowth and angiogenesis. As PTN-transgenic mice show an increased bone mass and mineralization, we decided to use this mouse model in the flight experiment and to study its potential role in counteracting bone loss in microgravity. Not all mouse strains are equally suitable for flight. After preliminary tests in the MDS breadboard at our animal facility on the behavior of different mouse strains, PTN-transgenic mice originally obtained in the BDF strain were backcrossed in the C57Bl/J10 strain before being used in this study. In order to

  3. Hematopoietic organ tumors post exposure and AML1 transcription factor

    International Nuclear Information System (INIS)

    This review describes the functions of AML1 transcription factor (tf) in hemopoiesis and the mechanism of hematopoietic organ tumorigenesis related with the product of chimaeric AML1 gene caused by chromosomal translocation and with AML1 mutation. Abnormality of AML1 (RUNX1) tf, an important factor for development and maintenance of hemopoiesis, is a representative cause of leukemia and is shown to be frequently observed in hematopoietic organ tumors of A-bomb survivors and radiation- and anticancer agent-treated patients. The dimmer via β-subunit (CDFβ) of AML1 product binds to DNA and functions at the budding of adult-type hematopoietic stem cells from aortic endothelial cells. Point mutations of AML1 are recognized in 46% A-bomb survivors with marrow dysplastic syndrome. Their distance from the explosion site is mostly 1.5-2.7 km and their exposure dose is low. Since histone acetylation is a key for hematopoietic cell tumorigenesis and differentiation by chimaeric AML/ETO tf, agent to control its activity is a target strategy for a new treatment. For this, analysis is important in such models as conditional knock-in mice. (K.H.)

  4. Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells.

    Science.gov (United States)

    Geyh, S; Oz, S; Cadeddu, R-P; Fröbel, J; Brückner, B; Kündgen, A; Fenk, R; Bruns, I; Zilkens, C; Hermsen, D; Gattermann, N; Kobbe, G; Germing, U; Lyko, F; Haas, R; Schroeder, T

    2013-09-01

    Ineffective hematopoiesis is a major characteristic of myelodysplastic syndromes (MDS) causing relevant morbidity and mortality. Mesenchymal stromal cells (MSC) have been shown to physiologically support hematopoiesis, but their contribution to the pathogenesis of MDS remains elusive. We show that MSC from patients across all MDS subtypes (n=106) exhibit significantly reduced growth and proliferative capacities accompanied by premature replicative senescence. Osteogenic differentiation was significantly reduced in MDS-derived MSC, indicated by cytochemical stainings and reduced expressions of Osterix and Osteocalcin. This was associated with specific methylation patterns that clearly separated MDS-MSC from healthy controls and showed a strong enrichment for biological processes associated with cellular phenotypes and transcriptional regulation. Furthermore, in MDS-MSC, we detected altered expression of key molecules involved in the interaction with hematopoietic stem and progenitor cells (HSPC), in particular Osteopontin, Jagged1, Kit-ligand and Angiopoietin as well as several chemokines. Functionally, this translated into a significantly diminished ability of MDS-derived MSC to support CD34+ HSPC in long-term culture-initiating cell assays associated with a reduced cell cycle activity. Taken together, our comprehensive analysis shows that MSC from all MDS subtypes are structurally, epigenetically and functionally altered, which leads to impaired stromal support and seems to contribute to deficient hematopoiesis in MDS. PMID:23797473

  5. Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia With an IDH1 and/or IDH2 Mutation

    Science.gov (United States)

    2016-04-27

    Newly Diagnosed Acute Myeloid Leukemia (AML); Untreated AML; AML Arising From Myelodysplastic Syndrome (MDS); AML Arising From Antecedent Hematologic Disorder (AHD); AML Arising After Exposure to Genotoxic Injury

  6. Trisomy 8 in Pediatric Acute Myeloid Leukemia. A NOPHO-AML Study

    DEFF Research Database (Denmark)

    Laursen, Anne Cathrine Lund; Sandahl, Julie Damgaard; Kjeldsen, Eigil;

    2016-01-01

    Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML...

  7. Measuring depression in nursing home residents with the MDS and GDS: an observational psychometric study

    Directory of Open Access Journals (Sweden)

    Fries Brant E

    2005-01-01

    Full Text Available Abstract Background The objective of this study was to examine the Minimum Data Set (MDS and Geriatric Depression Scale (GDS as measures of depression among nursing home residents. Methods The data for this study were baseline, pre-intervention assessment data from a research study involving nine nursing homes and 704 residents in Massachusetts. Trained research nurses assessed residents using the MDS and the GDS 15-item version. Demographic, psychiatric, and cognitive data were obtained using the MDS. Level of depression was operationalized as: (1 a sum of the MDS Depression items; (2 the MDS Depression Rating Scale; (3 the 15-item GDS; and (4 the five-item GDS. We compared missing data, floor effects, means, internal consistency reliability, scale score correlation, and ability to identify residents with conspicuous depression (chart diagnosis or use of antidepressant across cognitive impairment strata. Results The GDS and MDS Depression scales were uncorrelated. Nevertheless, both MDS and GDS measures demonstrated adequate internal consistency reliability. The MDS suggested greater depression among those with cognitive impairment, whereas the GDS suggested a more severe depression among those with better cognitive functioning. The GDS was limited by missing data; the DRS by a larger floor effect. The DRS was more strongly correlated with conspicuous depression, but only among those with cognitive impairment. Conclusions The MDS Depression items and GDS identify different elements of depression. This may be due to differences in the manifest symptom content and/or the self-report nature of the GDS versus the observer-rated MDS. Our findings suggest that the GDS and the MDS are not interchangeable measures of depression.

  8. Genomic, immunophenotypic, and NPM1/FLT3 mutational studies on 17 patients with normal karyotype acute myeloid leukemia (AML) followed by aberrant karyotype AML at relapse.

    Science.gov (United States)

    Wang, Eunice S; Sait, Sheila N J; Gold, David; Mashtare, Terry; Starostik, Petr; Ford, Laurie Ann; Wetzler, Meir; Nowak, Norma J; Deeb, George

    2010-10-15

    Normal karyotype (NK) is the most common cytogenetic group in acute myeloid leukemia (AML) diagnosis; however, up to 50% of these patients at relapse will have aberrant karyotype (AK) AML. To determine the etiology of relapsed AK AML cells, we evaluated cytogenetic, immunophenotypic, and molecular results of 17 patients with diagnostic NK AML and relapsed AK AML at our institute. AK AML karyotype was diverse, involving no favorable and largely (8 of 17) complex cytogenetics. Despite clear cytogenetic differences, immunophenotype and NPM1/FLT3 gene mutation status did not change between presentation and relapse in 83% (10 of 12) and 94% (15 of 16) cases, respectively. High-resolution array-based comparative genomic hybridization (aCGH) performed via paired aCGH on NK AML and AK AML samples from the same patient confirmed cytogenetic aberrations only in the relapse sample. Analysis of 16 additional diagnostic NK AML samples revealed no evidence of submicroscopic aberrations undetected by conventional cytogenetics in any case. These results favor evolution of NK AML leukemia cells with acquisition of novel genetic changes as the most common etiology of AK AML relapse as opposed to secondary leukemogenesis. Additional studies are needed to confirm whether AK AML cells represent selection of rare preexisting clones below aCGH detection and to further characterize the molecular lesions found at time of AK AML relapse. PMID:20875872

  9. CNS Involvement in AML Patient Treated with 5-Azacytidine

    Directory of Open Access Journals (Sweden)

    Diamantina Vasilatou

    2014-01-01

    Full Text Available Central nervous system (CNS involvement in acute myeloid leukemia (AML is a rare complication of the disease and is associated with poor prognosis. Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging. Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status.

  10. Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy

    DEFF Research Database (Denmark)

    Grövdal, Michael; Karimi, Mohsen; Khan, Rasheed;

    2010-01-01

    This prospective Phase II study is the first to assess the feasibility and efficacy of maintenance 5-azacytidine for older patients with high-risk myelodysplastic syndrome (MDS), chronic myelomonocytic leukaemia and MDS-acute myeloid leukaemia syndromes in complete remission (CR) after induction ......-IV thrombocytopenia and neutropenia occurred after 9.5 and 30% of the cycles, respectively, while haemoglobin levels increased during treatment. 5-azacytidine treatment is safe, feasible and may be of benefit in a subset of patients....

  11. New q-ary quantum MDS codes with distances bigger than q/2

    Science.gov (United States)

    He, Xianmang; Xu, Liqing; Chen, Hao

    2016-04-01

    The construction of quantum MDS codes has been studied by many authors. We refer to the table in page 1482 of (IEEE Trans Inf Theory 61(3):1474-1484, 2015) for known constructions. However, there have been constructed only a few q-ary quantum MDS [[n,n-2d+2,d

  12. New q-ary quantum MDS codes with distances bigger than q/2

    Science.gov (United States)

    He, Xianmang; Xu, Liqing; Chen, Hao

    2016-07-01

    The construction of quantum MDS codes has been studied by many authors. We refer to the table in page 1482 of (IEEE Trans Inf Theory 61(3):1474-1484, 2015) for known constructions. However, there have been constructed only a few q-ary quantum MDS [[n,n-2d+2,d

  13. Measurement of Radiation Belt Partcles by MDS-1 Onboard SEDA

    Science.gov (United States)

    Matsumoto, H.; Koshiishi, H.; Goka, T.

    The Space Environment Data Acquisition Equipment (SEDA) is on board the Mission Demonstration Test Satellite-1 (MDS-1) to measure the radiation environment, which was launched into geo-stationary transfer orbit (GTO) on February 4, 2002 with an apogee of about 35,700km, a perigee of about 500 km and an inclination of about 28.5 degrees. SEDA consists of the four instruments. Standard Dose Monitor monitors the electron and proton flux. Dosimeter measures the integrated radiation dose at fifty-six points of the satellite. Heavy Ion Telescope monitors the flux of heavy ions from He to Fe. Magnetometer measures the magnetic field in the magnetosphere. In this paper are described first results and comparison with the ISO standard model for the space environment

  14. Incidence and prevalence of myelodysplastic syndromes: data from the Düsseldorf MDS-registry.

    Science.gov (United States)

    Neukirchen, Judith; Schoonen, Wilma M; Strupp, Corinna; Gattermann, Norbert; Aul, Carlo; Haas, Rainer; Germing, Ulrich

    2011-12-01

    Population-based data on patients with MDS are scarce. Here we report the incidence and prevalence of MDS based on data from the Düsseldorf MDS Registry. Cases in the city of Düsseldorf in the study period were identified from the MDS Registry. We calculated crude, calendar-year, age- and sex-specific and European Standard Population age-standardized incidence rates as well as point prevalences per 100,000 The crude incidence rate was 4.15/100,000/year and the point prevalence per 100,000 persons of 7. We found that the incidence and prevalence of MDS was higher in men than women and increased sharply with increasing age. PMID:21708407

  15. Spatial Clustering of MDS in the Seattle-Puget Sound Region

    Science.gov (United States)

    Ross, Michelle E; Wakefield, Jon; Davis, Scott; De Roos, Anneclaire J

    2011-01-01

    OBJECTIVES Incidence of myelodysplastic syndromes (MDS) has been described in the United States since its inclusion in the Surveillance, Epidemiology, and End Results program in 2001, and the Seattle-Puget Sound region of Washington State has among the highest rates of the registries. In this investigation, we described small-scale incidence patterns of MDS within the Seattle-Puget Sound region from 2002 to 2006 and identified potential spatial clusters to inform planning of future studies of MDS etiology. METHODS We used a spatial disease mapping model to estimate smoothed relative risks for each census tract and to describe the spatial component of variability in the incidence rates. We also used two methods to describe the location of potential MDS clusters: the approach of Besag and Newell and the Kulldorff spatial scan statistic. RESULTS Our findings from all three approaches indicated the most likely areas of increased MDS incidence were located on Whidbey Island in Island County. CONCLUSION Interpretation is limited because our data are based on the residential location of the MDS case only at the time of diagnosis. Nevertheless, inclusion of identified cluster regions in future population-based research and investigation of individual-level exposures could shed light on environmental risk factors for MDS. PMID:20101455

  16. The AML1/ETO fusion protein activates transcription of BCL-2

    OpenAIRE

    Klampfer, Lidija; Zhang, Jin; Zelenetz, Andrew O.; Uchida, Hideo; Nimer, Stephen D.

    1996-01-01

    The AML1 gene, located on chromosome 21, is involved in several distinct chromosomal translocations in human leukemia. In t(8;21) acute myelogenous leukemia (AML), the AML1 gene is juxtaposed to the ETO gene located on chromosome 8, generating an AML1/ETO fusion protein. Both AML1/ETO and the AML1 proteins recognize the same consensus DNA-binding motif (TGT/CGGT), which is found in the promoters of several genes involved in hematopoiesis. We found that two myeloid ...

  17. Osteolytic Bone Lesions – A Rare Presentation of AML M6

    OpenAIRE

    N. Geetha; Sreelesh, K.P.; Priya, M. J.; Lali, V.S.; N. Rekha

    2015-01-01

    Acute myeloid leukemia (AML) M6 is a rare form of AML accounting for < 5 % of all AML. Extramedullary involvement is very rarely seen in this entity. Skeletal lesion has not been described in AML M6 before. We discuss the case of a 17 year old boy with AML M6, who presented with osteolytic lesion of right humerus. He was treated with induction and consolidation chemotherapy. The present case is the first report in literature of AML M6 presenting with skeletal lesions.

  18. SIMILARITIES OF ELDERLY AND THERAPY-RELATED AML

    Directory of Open Access Journals (Sweden)

    Francesco D'Alò

    2011-11-01

    Full Text Available Acute myeloid leukemia (AML is a clonal disorder of the hematopoietic stem cell, typical of the elderly, with a median age of over 60 years at diagnosis. In AML, older age is one of the strongest independent adverse prognostic factor, associated with decreased complete response rate, worse disease-free and overall survival, with highest rates of treatment related mortality, resistant disease and relapse, compared to younger patients. While clinical risk factors do not significantly differ between older and younger patients, outcomes are compromised in elderly patients not only by increased comorbidities and susceptibility to toxicity from therapy, but it is now recognized that elderly AML represents a biologically distinct disease, that is itself more aggressive and less responsive to therapy. In elderly individuals prolonged exposure to environmental carcinogens may be the basis for the aggressive biology of the disease. This may also be the basis for similarities between elderly AML and therapy-related myeloid malignancies, mimicking toxic effects of previous cytotoxic treatments on hematopoietic stem cells. Age is itself a risk factor for t-MN, which are more frequent in elderly patients, where also a shorter latency between treatment of primary tumor and t-MN has been reported. Similarities between therapy-related malignancies and elderly AML include morphological aspects, as the presence of multilineage dysplasia preceding and/or concomitant to the development of leukemia, and adverse cytogenetics, including poor karyotype and chromosome 5 and/or 7 abnormalities. Looking at molecular prognosticators in elderly AML, similar to t-MN,  reduced frequency of favorable factors, as reduced number of NPM1 and CEBPA mutated cases has been observed, together with increased incidence of negative factors, as increased MDR1 expression, accelerated telomere shortening  and frequency of methylation changes. Given the unfavorable prognosis of elderly and

  19. Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic–pathologic correlation

    International Nuclear Information System (INIS)

    Classic (triphasic) renal angiomyolipoma (AML) is currently classified as a neoplasm of perivascular epithelioid cells. For diagnosis of AML, the use of thin-section non-contrast enhanced CT (NECT) improves diagnostic accuracy; however, identifying gross fat within a very small AML is challenging and often better performed with chemical-shift MRI. Although the presence of gross intra-tumoural fat is essentially diagnostic of AML; co-existing intra-tumoural fat and calcification may represent renal cell carcinoma (RCC). Differentiating AML from retroperitoneal sarcoma can be difficult when AML is large; the feeding vessel and claw signs are suggestive imaging findings. AML can haemorrhage, with intra-tumoural aneurysm size >5 mm a more specific predictor of future haemorrhage than tumor size >4 cm. Diagnosis of AML in the setting of acute haemorrhage is complex; comparison studies or follow-up imaging may be required. Not all AML contain gross fat and imaging features of AML without visible fat overlap with RCC; however, homogeneity, hyperdensity at NECT, low T2-weighted signal intensity and, microscopic fat are suggestive features. Patients with tuberous sclerosis often demonstrate a combination of classic and minimal fat AML, but are also at a slightly increased risk for RCC and should be imaged cautiously. Several rare pathological variants of AML exist including AML with epithelial cysts and epithelioid AML, which have distinct imaging characteristics. Classic AML, although benign, can be locally invasive and the rare epithelioid AML can be frankly malignant. The purpose of this review is to highlight the imaging manifestations of 10 uncommon and unusual variants of AML using pathological correlation

  20. I-123 based development program at MDS Nordion

    International Nuclear Information System (INIS)

    Ultra-pure iodine-123 (>99.8% radionuclide purity) has been produced by the irradiation of enriched xenon-124 (99.8%) on external beam lines of CP-42 and TR-30 cyclotrons. Typically, an incident proton energy of 24-30 MeV has resulted in a yield of 6.6 mCi/μAh at the end of processing (end of bombardment + 9h). The largest quantity of iodine-123 produced on a single run has been 12 Ci. The availability of large quantities of ultra-pure I-123 and reliable production four to five times per week has led to a vibrant radiopharmaceutical programme based on I-123. Currently, a number of pharmaceuticals have been licensed in Canada or are undergoing clinical trials in the United States. MDS Nordion has state of the art facilities such as Class 100 Isolators in Class 10,000 Clean Rooms for aseptic filling operations and has developed expertise in Ci scale labelling operations. (author)

  1. HEMATOPOIETIC CELL TRANSPLANTATION FOR OLDER PATIENTS WITH MDS

    Directory of Open Access Journals (Sweden)

    Mazyar Shadman

    2014-09-01

    Full Text Available The incidence of myeloid malignancies, including myelodysplastic syndromes (MDS increases with age. While several therapeutic modalities have been developed, for most of these patients the only treatment with curative potential is allogeneic hematopoietic cell transplantation (HCT. The development of reduced/low intensity transplant conditioning regimens allows to successfully transplant patients in their ‘60s and even ‘70s, although comorbidities may determine who does come to transplantation and who does not. Also, as many as half of the patients will develop graft versus host disease (GVHD, even with HLA matched  donors, requiring therapy for extended periods of time,  and GVHD and treatment  with glucocorticoids is likely to impact the quality  of life. Nevertheless, dependent upon disease stage at HCT, the presence of comorbidities and the regimen used, 30% to 50% of patients  60 years of age or older, may survive long-term cured of their disease. Future studies should focus on the incorporation of non-transplant modalities into the overall transplant approach, the prevention of GVHD, and the utilization of immunotherapy to reduce the incidence of relapse and GVHD and further improve overall transplant success.

  2. MDS-Multifunctional Dynamometer for Application in Space

    Science.gov (United States)

    Adamcik, G.; Barta, N.; Talla, R.; Angeli, T.; Kozlovskaya, I. B.; Grigoriev, A. I.; Tschan, H.; Bachl, N.

    2008-06-01

    The project MDS (Multifunctional Dynamometer for Application in Space) is an international collaboration of the University of Vienna (Faculty of Sport Science, Department of Sport and Exercise Physiology), the Russian Academy of Sciences (Institute of Biomedical Problems) and the Technical University of Vienna (Institute for Engineering Design and Logistics Engineering) with the aim to develop a training and diagnostic device that counteracts the muscle and bone loss during long term space flights. Due to the scientific results of the last years research in space medicine, it is well known, that the muscles and bones of the lower extremities and the trunk are most affected by the atrophy. Based on this knowledge a various number of resistance exercises can be done in order to train the muscles of these parts of the body and to increase the efficiency of the training by intra- and intermuscular coordination. The resisting power for the training is provided by an electric motor, thereby force, position and speed of the training can be well-regulated for different training modes.

  3. MDS 3.0 for Nursing Homes and Swing Bed Providers

    Data.gov (United States)

    U.S. Department of Health & Human Services — The MDS is a powerful tool for implementing standardized assessment and for facilitating care management in nursing homes (NHs) and non-critical access hospital...

  4. Energetic particle cross-field diffusion: Interaction with Magnetic Decreases (MDs

    Directory of Open Access Journals (Sweden)

    B. T. Tsurutani

    1999-01-01

    Full Text Available Magnetic field Decreases (MDs are detected in the heliospheric polar regions. The MDs have minimum spatial scales sizes of 25 proton thermal gyroradii, and are typically bounded by tangential or rotational discontinuities. The distribution of the magnitudes of the decreases within AIDs is a continuum, with the smallest decreases being most frequent in occurrence. The largest decreases can be 80% of the ambient field. The thickness distribution is also a continuum, and is shown to be independent of the field magnitude decrease. Charged particle interactions with the MDs lead to particle guiding center displacements and hence particle cross-held diffusion. We develop a diffusion model to apply to energetic ion interactions with MDs using the MD properties described in this paper. One specific day of data is used to illustrate that the particle cross-field diffusion will be extremely rapid due to such interactions.

  5. 分布式操作系统MDS/DOS的设计与实现%Design and Implementation of the Distributed Operating System MDS/DOS

    Institute of Scientific and Technical Information of China (English)

    何炎祥; 刘蓬

    1995-01-01

    介绍了MDS/DOS的设计思想和部分实现技术.MDS/DOS是在微机操作系统MS-DOS的基础上,通过增加分布式通信与资源管理模块(DCRM)、分布式命令解释器(DCI),并建立相应的通信机制后修改扩充而成.它已实现了分布式操作系统的基本功能.

  6. [Treatment outcome for myelodysplastic syndromes (MDS) obtained by the Polish Children's Leukemia/Lymphoma Study Group].

    Science.gov (United States)

    Chybicka, A; Kołecki, P; Pietras, W; Bogusławska-Jaworska, J; Wójcik, D; Armata, J; Eliasińska, A; Kowalczyk, J; Jackowska, T; Klus, K; Matysiak, M; Krauze, A; Stefańska, K; Rokicka-Milewska, R; Wiśniewska-Slusarz, H

    1998-02-01

    Fourty children with MDS treated in seven centres of The Polish Children's Leukemia Lymphoma Study Group in period 1975-1998y were included to the study. In 16 children RAEB-T, in 2 CMML in 10 RA and in 12 RAEB were diagnosed. Our and literature data showed that BMT is the best therapy for children with MDS. For children, who don't have a donor for BMT. Roacutan therapy seems to be the most effective. PMID:9686518

  7. Schattenwirtschaft und Arbeitsplatzbeschaffung

    OpenAIRE

    Merz, Joachim

    1996-01-01

    Ziel dieser Studie ist die empirisch fundierte Auseinandersetzung mit dem Thema Schattenwirtschaft und Arbeitsplatzschaffung. Die hier aufgefächerte Diskussion des Themas in Wirtschaft, Sozialpolitik und Gesellschaft, der weitere Diskurs und die empirische Fundierung erfordern eine klare und dann folgende begriffliche Abgrenzung der Schattenwirtschaft. Argumente der Diskussion zu Ursachen und positiven und negativen Wirkungen der Schattenwirtschaft auf die Arbeitsplatzbeschaffung werden im An...

  8. AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model

    OpenAIRE

    Wunderlich, Mark; Mizukawa, Benjamin; Chou, Fu-Sheng; Sexton, Christina; Shrestha, Mahesh; Saunthararajah, Yogen; Mulloy, James C.

    2013-01-01

    A relevant xenograft chemotherapy model was developed by using standard AML induction therapy drugs and primary human AML patient samples.Human AML cells show significantly increased sensitivity to in vivo chemotherapy treatment compared with murine LSK and total bone marrow cells.

  9. AML1/RUNX1 Phosphorylation by Cyclin-Dependent Kinases Regulates the Degradation of AML1/RUNX1 by the Anaphase-Promoting Complex‡

    OpenAIRE

    Biggs, Joseph R.; Peterson, Luke F.; Zhang, Youhong; Kraft, Andrew S.; Zhang, Dong-Er

    2006-01-01

    AML1 (RUNX1) regulates hematopoiesis, angiogenesis, muscle function, and neurogenesis. Previous studies have shown that phosphorylation of AML1, particularly at serines 276 and 303, affects its transcriptional activation. Here, we report that phosphorylation of AML1 serines 276 and 303 can be blocked in vivo by inhibitors of the cyclin-dependent kinases (CDKs) Cdk1 and Cdk2. Furthermore, these residues can be phosphorylated in vitro by purified Cdk1/cyclin B and Cdk2/cyclin A. Mutant AML1 pro...

  10. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

    DEFF Research Database (Denmark)

    Bruedigam, Claudia; Bagger, Frederik Otzen; Heidel, Florian H.;

    2014-01-01

    priority. Here, we show that targeting telomerase activity eradicates AML LSCs. Genetic deletion of the telomerase subunit Terc in a retroviral mouse AML model induces cell-cycle arrest and apoptosis of LSCs, and depletion of telomerase-deficient LSCs is partially rescued by p53 knockdown. Murine Terc......(-/-) LSCs express a specific gene expression signature that can be identified in human AML patient cohorts and is positively correlated with patient survival following chemotherapy. In xenografts of primary human AML, genetic or pharmacological inhibition of telomerase targets LSCs, impairs leukemia...... progression, and delays relapse following chemotherapy. Altogether, these results establish telomerase inhibition as an effective strategy for eliminating AML LSCs....

  11. Osteolytic bone lesions – A rare presentation of AML M6.

    Directory of Open Access Journals (Sweden)

    Geetha N.

    2015-02-01

    Full Text Available Acute myeloid leukemia (AML M6 is a rare form of AML  accounting  for < 5 % of all AML.  Extramedullary involvement  is very rarely seen in this entity.  Skeletal lesion has not been described in AML M6 before. We discuss the case of  a 17 year old boy with AML M6 who presented with  osteolytic lesion of right humerus.  He was treated with  induction and consolidation chemotherapy. The present case is the first report in literature of AML M6 presenting with skeletal lesions.

  12. Cell Type Dependent Regulation of Multidrug Resistance-1 Gene Expression by AML1-ETO

    OpenAIRE

    Hines, Robert; Boyapati, Anita; Zhang, Dong-Er

    2007-01-01

    The AML1-ETO fusion protein is generated from the 8;21 chromosome translocation that is commonly identified in acute myeloid leukemia. AML1-ETO is a DNA binding transcription factor and has been demonstrated to play a critical role in promoting leukemogenesis. Therefore, it is important to define the molecular mechanism of AML1-ETO in the regulation of gene expression. Here, we report that the effect of AML1-ETO on the promoter of multidrug resistance-1 (MDR1) gene, a known AML1-ETO target, i...

  13. Osteolytic bone lesions – A rare presentation of AML M6.

    OpenAIRE

    Geetha N; Sreelesh KP; Priya Mary Jacob; Lali VS; Rekha A Nair

    2015-01-01

    Acute myeloid leukemia (AML) M6 is a rare form of AML  accounting  for < 5 % of all AML.  Extramedullary involvement  is very rarely seen in this entity.  Skeletal lesion has not been described in AML M6 before. We discuss the case of  a 17 year old boy with AML M6 who presented with  osteolytic lesion of right humerus.  He was treated with  induction and consolidation chemotherapy. The present case is the first report in literature of AML M6 presenting with skeletal lesions.

  14. In vivo consequences of AML1-ETO fusion protein expression for hematopoiesis

    OpenAIRE

    Cabezas Wallscheid, Nina

    2010-01-01

    The t(8;21) (q22;q22) translocation fusing the ETO (also known as MTG8) gene on human chromosome 8 with the AML1 (also called Runx1 or CBFα) gene on chromosome 21 is one of the most common genetic aberrations found in acute myeloid leukemia (AML). This chromosomal translocation occurs in 12 % of de novo AML cases and in up to 40 % of the AML-M2 subtype of the French-American-British classification. To date, the in vivo function of aberrant AML1-ETO fusion protein expression has been investig...

  15. Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation†

    OpenAIRE

    Burel, Sebastien A.; Harakawa, Nari; Zhou, Liming; Pabst, Thomas; Tenen, Daniel G.; Zhang, Dong-Er

    2001-01-01

    The fusion gene AML1-ETO is the product of t(8;21)(q22;q22), one of the most common chromosomal translocations associated with acute myeloid leukemia. To investigate the impact of AML1-ETO on hematopoiesis, tetracycline-inducible AML1-ETO-expressing cell lines were generated using myeloid cells. AML1-ETO is tightly and strongly induced upon tetracycline withdrawal. The proliferation of AML1-ETO+ cells was markedly reduced, and most of the cells eventually underwent apoptosis. RNase protection...

  16. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.

    OpenAIRE

    Meyers, S; Lenny, N; Hiebert, S W

    1995-01-01

    The AML-1/CBF beta transcription factor complex is targeted by both the t(8;21) and the inv(16) chromosomal alterations, which are frequently observed in acute myelogenous leukemia. AML-1 is a site-specific DNA-binding protein that recognizes the enhancer core motif TGTGGT. The t(8;21) translocation fuses the first 177 amino acids of AML-1 to MTG8 (also known as ETO), generating a chimeric protein that retains the DNA-binding domain of AML-1. Analysis of endogenous AML-1 DNA-binding complexes...

  17. [Results of the treatment of myelodysplastic syndrome (MDS)obtained by the Polish Paediatric Leukaemia /Lymphoma Study Group].

    Science.gov (United States)

    Chybicka, A; Wójcik, D; Pietras, W; Bogusławska-Jaworska, J; Kolecki, P; Balcerska, A; Balwierz, W; Bubała, H; Eliasinska, A; Kowalczyk, J; Jackowska, T; Klus, K; Krenke, K; Kurylak, A; Malinowska, I; Matysiak, M; Stefańska, K; Stefaniak, M J; Rokicka-Milewska, R; Wiśniewska-Slusarz, H; Sońta-Jakimczyk, D; Wysocki, M

    2000-01-01

    Sixty children with MDS treated in six centres of the Polish Paediatric Leukaemia/Lymphoma Study Group in the period 1975-1999 were included in the study. In 20 children RAEB-T, in 13 RA, in 21 RAEB and in 6 CMML were diagnosed. Our own and literature data showed that BMT is the best therapy for children with MDS. We need a new comprehensive protocol for the diagnosis and treatment of children with MDS in Poland. PMID:12021466

  18. Physical properties of Kentucky's AML landslides: Case studies analyzed

    International Nuclear Information System (INIS)

    Once an abandoned mined land (AML) landslide occurs and is identified as an emergency, engineers must rapidly implement a slope stabilization design. Correct slope remediation solutions are generally derived from well-executed geotechnical examinations. This paper summarizes a large body of geotechnical data compiled by the US office of Surface Mining Reclamation and Enforcement (OSM) from AML landslides in eastern Kentucky. Special attention is placed on the examination of subsurface failures, phreatic water levels, soil profiles, and soil composition information from numerous borehole exploration programs. Strength properties calculated from laboratory procedures and stability analysis techniques were also reviewed. Laboratory-determined soil shear strength values were found to be higher than those inferred from stability analysis. This suggests that postfailure determinations of the phreatic surface may be largely inappropriate when used in stability analysis or that laboratory-measured shear strengths are ineffective in replicating in situ colluvium/spoil slope properties

  19. Cloning of chicken AML1-EVI-1 fusion protein

    Czech Academy of Sciences Publication Activity Database

    Balková, Simona; Buchtová, Marcela; Matalová, Eva; Míšek, Ivan

    Plzeň, 2009. s. 42-42. [Morphology 2009. 45th International Congress on Anatomy and 46th Lojda symposium on Histochemy. 07.09.2009-09.09.2009, Plzeň] R&D Projects: GA ČR GA304/09/0725 Institutional research plan: CEZ:AV0Z50450515 Keywords : AML-1-EVI-1 * cloning Subject RIV: EG - Zoology

  20. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

    OpenAIRE

    Yuan, Youzhong; Zhou, Liming; Miyamoto, Toshihiro; Iwasaki, Hiromi; Harakawa, Nari; Hetherington, Christopher J.; Burel, Sebastien A.; Lagasse, Eric; Weissman, Irving L.; Akashi, Koichi; Zhang, Dong-Er

    2001-01-01

    The t(8;21) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML). The translocation, which involves the AML1 gene on chromosome 21 and the ETO gene on chromosome 8, generates an AML1-ETO fusion transcription factor. To examine the effect of the AML1-ETO fusion protein on leukemogenesis, we made transgenic mice in which expression of AML1-ETO is under the control of the human MRP8 promoter (hMRP8-AML1-ETO). AML1-ETO is specifically expressed in mye...

  1. AML1/RUNX1 Works as a Negative Regulator of c-Mpl in Hematopoietic Stem Cells*

    OpenAIRE

    Satoh, Yusuke; Matsumura, Itaru; Tanaka, Hirokazu; Ezoe, Sachiko; Fukushima, Kentaro; Tokunaga, Masahiro; Yasumi, Masato; Shibayama, Hirohiko; Mizuki, Masao; Era, Takumi; Okuda, Tsukasa; Kanakura, Yuzuru

    2008-01-01

    In this study, we analyzed the roles for AML1/RUNX1 in the regulation of the c-mpl promoter. Wild-type AML1 activated the c-mpl promoter through the proximal AML-binding site in luciferase assays using 293T and HeLa cells. In accord with this result, electrophoretic mobility shift assay and chromatin immunoprecipitation assays demonstrated that AML1 bound to this site. Next, we analyzed the function of AML1 using a mutant of AML1 lacking the C terminus (AML1dC), which ...

  2. Reduced-intensity conditioned allogeneic SCT in adults with AML.

    Science.gov (United States)

    Reshef, R; Porter, D L

    2015-06-01

    AML is currently the most common indication for reduced-intensity conditioned (RIC) allo-SCT. Reduced-intensity regimens allow a potent GVL response to occur with minimized treatment-related toxicity in patients of older age or with comorbidities that preclude the use of myeloablative conditioning. Whether RIC SCT is appropriate for younger and more standard risk patients is not well defined and the field is changing rapidly; a prospective randomized trial of myeloablative vs RIC (BMT-CTN 0901) was recently closed when early results indicated better outcomes for myeloablative regimens. However, detailed results are not available, and all patients in that study were eligible for myeloablative conditioning. RIC transplants will likely remain the standard of care as many patients with AML are not eligible for myeloablative conditioning. Recent publication of mature results from retrospective and prospective cohorts provide contemporary efficacy and toxicity data for these attenuated regimens. In addition, recent studies explore the use of alternative donors, introduce regimens that attempt to reduce toxicity without reducing intensity, and identify predictive factors that pave the way to personalized approaches. These studies paint a picture of the future of RIC transplants. Here we review the current status of RIC allogeneic SCT in AML. PMID:25730186

  3. Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype

    OpenAIRE

    Vradii, Diana; Zaidi, Sayyed K.; Lian, Jane B.; van Wijnen, Andre J; Stein, Janet L.; Stein, Gary S.

    2005-01-01

    The multifunctional C terminus of the hematopoietic AML1 transcription factor interacts with coregulatory proteins, supports the convergence and integration of physiological signals, and contains the nuclear matrix targeting signal, the protein motif that is necessary and sufficient to target AML1 to subnuclear sites. The (8;21) chromosomal translocation, which replaces the C terminus of AML1 with the ETO protein, modifies subnuclear targeting of AML1 in acute myeloid leukemia (AML) and resul...

  4. Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy

    DEFF Research Database (Denmark)

    Grövdal, Michael; Karimi, Mohsen; Khan, Rasheed;

    2010-01-01

    This prospective Phase II study is the first to assess the feasibility and efficacy of maintenance 5-azacytidine for older patients with high-risk myelodysplastic syndrome (MDS), chronic myelomonocytic leukaemia and MDS-acute myeloid leukaemia syndromes in complete remission (CR) after induction...... with CDKN2B methylation status or karyotype. Median overall survival was 20 months. Hypermethylation of CDH1 was significantly associated with low CR rate, early relapse, and short overall survival (P = 0.003). 5-azacytidine treatment, at a dose of 60 mg/m(2) was well tolerated. Grade III......-IV thrombocytopenia and neutropenia occurred after 9.5 and 30% of the cycles, respectively, while haemoglobin levels increased during treatment. 5-azacytidine treatment is safe, feasible and may be of benefit in a subset of patients....

  5. Improved survival in MDS patients receiving iron chelation therapy - a matched pair analysis of 188 patients from the Düsseldorf MDS registry.

    Science.gov (United States)

    Neukirchen, Judith; Fox, Frank; Kündgen, Andrea; Nachtkamp, Kathrin; Strupp, Corinna; Haas, Rainer; Germing, Ulrich; Gattermann, Norbert

    2012-08-01

    MDS patients are prone to develop transfusional iron overload. Iron overload may partly explain why transfusion dependency is associated with a decreased likelihood of survival. Our matched-pair analysis included 94 patients on long-term chelation therapy and 94 matched patients without it. All patients had iron overload, defined as serum ferritin (SF) above 1000 ng/ml or a history of multiple transfusions and SF ≥ 500 ng/ml. Median SF was 1954 ng/ml in chelated and 875 ng/ml in non-chelated patients. The difference in median survival (74 vs. 49 months, respectively; p=0.002) supports the idea that iron chelation therapy is beneficial for MDS patients. PMID:22564985

  6. Transcriptome Profiling of Pediatric Core Binding Factor AML.

    Directory of Open Access Journals (Sweden)

    Chih-Hao Hsu

    Full Text Available The t(8;21 and Inv(16 translocations disrupt the normal function of core binding factors alpha (CBFA and beta (CBFB, respectively. These translocations represent two of the most common genomic abnormalities in acute myeloid leukemia (AML patients, occurring in approximately 25% pediatric and 15% of adult with this malignancy. Both translocations are associated with favorable clinical outcomes after intensive chemotherapy, and given the perceived mechanistic similarities, patients with these translocations are frequently referred to as having CBF-AML. It remains uncertain as to whether, collectively, these translocations are mechanistically the same or impact different pathways in subtle ways that have both biological and clinical significance. Therefore, we used transcriptome sequencing (RNA-seq to investigate the similarities and differences in genes and pathways between these subtypes of pediatric AMLs. Diagnostic RNA from patients with t(8;21 (N = 17, Inv(16 (N = 14, and normal karyotype (NK, N = 33 were subjected to RNA-seq. Analyses compared the transcriptomes across these three cytogenetic subtypes, using the NK cohort as the control. A total of 1291 genes in t(8;21 and 474 genes in Inv(16 were differentially expressed relative to the NK controls, with 198 genes differentially expressed in both subtypes. The majority of these genes (175/198; binomial test p-value < 10(-30 are consistent in expression changes among the two subtypes suggesting the expression profiles are more similar between the CBF cohorts than in the NK cohort. Our analysis also revealed alternative splicing events (ASEs differentially expressed across subtypes, with 337 t(8;21-specific and 407 Inv(16-specific ASEs detected, the majority of which were acetylated proteins (p = 1.5 x 10(-51 and p = 1.8 x 10(-54 for the two subsets. In addition to known fusions, we identified and verified 16 de novo fusions in 43 patients, including three fusions involving NUP98 in six

  7. Time-dependent changes in mortality and transformation risk in MDS.

    Science.gov (United States)

    Pfeilstöcker, Michael; Tuechler, Heinz; Sanz, Guillermo; Schanz, Julie; Garcia-Manero, Guillermo; Solé, Francesc; Bennett, John M; Bowen, David; Fenaux, Pierre; Dreyfus, Francois; Kantarjian, Hagop; Kuendgen, Andrea; Malcovati, Luca; Cazzola, Mario; Cermak, Jaroslav; Fonatsch, Christa; Le Beau, Michelle M; Slovak, Marilyn L; Levis, Alessandro; Luebbert, Michael; Maciejewski, Jaroslaw; Machherndl-Spandl, Sigrid; Magalhaes, Silvia M M; Miyazaki, Yasushi; Sekeres, Mikkael A; Sperr, Wolfgang R; Stauder, Reinhard; Tauro, Sudhir; Valent, Peter; Vallespi, Teresa; van de Loosdrecht, Arjan A; Germing, Ulrich; Haase, Detlef; Greenberg, Peter L

    2016-08-18

    In myelodysplastic syndromes (MDSs), the evolution of risk for disease progression or death has not been systematically investigated despite being crucial for correct interpretation of prognostic risk scores. In a multicenter retrospective study, we described changes in risk over time, the consequences for basal prognostic scores, and their potential clinical implications. Major MDS prognostic risk scoring systems and their constituent individual predictors were analyzed in 7212 primary untreated MDS patients from the International Working Group for Prognosis in MDS database. Changes in risk of mortality and of leukemic transformation over time from diagnosis were described. Hazards regarding mortality and acute myeloid leukemia transformation diminished over time from diagnosis in higher-risk MDS patients, whereas they remained stable in lower-risk patients. After approximately 3.5 years, hazards in the separate risk groups became similar and were essentially equivalent after 5 years. This fact led to loss of prognostic power of different scoring systems considered, which was more pronounced for survival. Inclusion of age resulted in increased initial prognostic power for survival and less attenuation in hazards. If needed for practicability in clinical management, the differing development of risks suggested a reasonable division into lower- and higher-risk MDS based on the IPSS-R at a cutoff of 3.5 points. Our data regarding time-dependent performance of prognostic scores reflect the disparate change of risks in MDS subpopulations. Lower-risk patients at diagnosis remain lower risk whereas initially high-risk patients demonstrate decreasing risk over time. This change of risk should be considered in clinical decision making. PMID:27335276

  8. Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically.

    Science.gov (United States)

    Zapotocky, Michal; Mejstrikova, Ester; Smetana, Karel; Stary, Jan; Trka, Jan; Starkova, Julia

    2012-06-28

    Valproic acid (VPA) has extensive effects on leukemic blasts through its inhibition of histone deacetylases. The main goal of this study was to identify the subgroup of patients who may benefit most from VPA treatment. We examined the significance of t(8;21) chromosomal aberration for VPA treatment response among acute myeloid leukemia (AML) patients by direct comparison of AML1/ETO-negative vs. positive leukemic cell-lines as well as bone marrow blasts from AML patients. In t(8;21) AML, leukemogenesis is supposed to be induced via aberrant recruitment of histone deacetylases. AML cell lines of different genotypes (Kasumi-1, Kasumi-6, MV4;11, K562) and diagnostic bone marrow samples from patients were treated with VPA. VPA induced apoptosis in AML1/ETO-positive and MLL-AF4-positive cells in a dose-dependent manner. Differentiation, as indicated by changes in immunophenotype, was observed only in AML1/ETO-positive cells. VPA increased the expression of AML1 target genes - PU.1, C/EBPa, BPI and IGFBP7 only in AML1/ETO-positive cells. This AML1/ETO-specific effect was confirmed also using patient blasts isolated at the time of diagnosis. AML1/ETO-positive leukemia shows specific mechanism of VPA residing from differentiation followed by apoptosis that is accompanied by an increase in the expression of repressed AML1 target genes. Our data suggest that AML1/ETO-positive patients might derive the greatest benefit from VPA treatment. PMID:22261333

  9. Anti-thymocyte Globulin plus Etanercept as Therapy for Myelodysplastic Syndromes (MDS): a Phase II Study

    OpenAIRE

    Scott, Bart L.; Ramakrishnan, Aravind; Fosdal, Mark; Storer, Barry; Becker, Pamela; Petersdorf, Steve; Deeg, H. Joachim

    2010-01-01

    Immunosuppressive therapies have proven valuable in treating patients with myelodysplastic syndromes (MDS). We evaluated the combination of equine anti-thymocyte globulin (ATGAM®) and the soluble TNF receptor etanercept (Enbrel®) in a phase II trial. Twenty-five patients with MDS (4-RA, 2-RARS, 15-RCMD, 3-RCMD-RS, 1-RAEB-1) in IPSS risk groups low (n=11) or intermediate-1 (n=14) were enrolled. All patients were platelet or red cell transfusion dependent. Nineteen patients completed therapy wi...

  10. Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).

    Science.gov (United States)

    Schneider, Friederike; Hoster, Eva; Schneider, Stephanie; Dufour, Annika; Benthaus, Tobias; Kakadia, Purvi M; Bohlander, Stefan K; Braess, Jan; Heinecke, Achim; Sauerland, Maria C; Berdel, Wolfgang E; Buechner, Thomas; Woermann, Bernhard J; Feuring-Buske, Michaela; Buske, Christian; Creutzig, Ursula; Thiede, Christian; Zwaan, Michel C; van den Heuvel-Eibrink, Marry M; Reinhardt, Dirk; Hiddemann, Wolfgang; Spiekermann, Karsten

    2012-01-01

    Prognosis of AML in elderly patients is poor due to adverse patient characteristics and comorbidities. In addition, disease-associated parameters reveal differences between older and younger patients with AML. Survival in normal karyotype AML (NK-AML) is influenced by different clinical and molecular markers. The aim of this work was to investigate the frequencies of molecular markers in patients with NK-AML with a focus on NPM1 mutations and FLT3-ITD in different age groups. In the present study, we analyzed the frequencies of mutations of NPM1 and FLT3-ITD in a cohort of 1,321 adult patients and 148 children with AML treated within the AMLCG99, the AML98, and AML04 trials and their distribution in different age groups. Additionally, the frequencies of mutations in CEBPA genes, FLT3-TKD, and MLL-PTD were analyzed in the cohort with NK-AML (n = 729). Our data show that the presence of mutations of NPM1 (from 60% to 40%) and FLT3-ITD (from 50% to 20%) significantly decreased with age in adult AML. Consequently, the proportion of NPM1-/FLT3-ITD- patients increased with age. The decreasing frequency of NPM1 mutations in elderly patients was paralleled by a reduced complete remission (CR) rate in the elderly of 55% compared to 80% in the younger patients. By contrast, the frequencies of other gene mutations, like FLT3-TKD and MLL-PTD, and mutations in CEBPA were not age-dependent. The decreasing frequency of the favorable NPM1 mutations with increasing age may partially explain the worse outcome in the elderly patients. Furthermore, the increasing amount of elderly patients without NPM1 mutations or FLT3-ITD suggests that other molecular and clinical risk factors may influence prognosis in this age group. PMID:21744003

  11. Diskurs und Praxis: Geschlecht und Gewalt

    Directory of Open Access Journals (Sweden)

    Angela Koch

    2003-11-01

    Full Text Available Der Sammelband befasst sich kulturwissenschaftlich mit den Verschränkungen der diskursiven Repräsentationen von Geschlecht und Gewalt, mit deren alltäglichen Erscheinungsformen und juristischen Auslegungen. Im Vordergrund steht die personale Gewalttätigkeit als physisches Mittel des Zwangs, der Dominanz und der Macht. Der Band geht auf die Tagung „Frauen und Gewalt“ zurück, die im Oktober 2001 in Greifswald stattgefunden hat, und versammelt 18 Beiträge, die unterschiedliche Facetten des Themenkomplexes behandeln: Gewalt gegen Frauen wie Inzest, Vergewaltigung, Folter, Anprangerung im Internet, und weibliche Gewalttätigkeit wie Verbrechen, Mord, Kindsmord, physische Gewalt.

  12. Exploiting AML algorithm for multiple acoustic source 2D and 3D DOA estimations

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The approximate maximum likelihood (AML) algorithm shows promises for joint estimations of acoustic source spectrum and direction-of-arrival (DOA). For the multisource case, the AML algorithm remains feasible as one considers an alternating projection procedure based on sequential iterative search on single source parameters. In order to perform multisource beamforming operations, earlier, we used a two-dimensional (2D) sensor array with 2D AML to obtain the DOA estimations for sources in the far field of t...

  13. Prognostic Value of AML1/ETO Fusion Transcripts in Patients with Acute Myelogenous Leukemia

    OpenAIRE

    Cho, Eun Kyung; Bang, Soo Mee; Ahn, Jeong Yeal; Yoo, Seung Min; Park, Pil Whan; Seo, Yieh Hea; Shin, Dong Bok; Lee, Jae Hoon

    2003-01-01

    Background The t (8;21) (q22;q22), which produces the fusion gene AML1/ETO, is associated with relatively good prognosis and, in particular, with a good response to cytosine arabinoside. Analysis of t (8;21) positive leukemic blasts has shown characteristic morphological and immunological features. We performed this study to investigate the incidence of AML1/ETO rearrangement in adult acute myelogenous leukemia (AML), especially in M2 subtype, to make a comparison of clinical, morphological a...

  14. Novel formulation of cytarabine and daunorubicin: A new hope in AML treatment

    OpenAIRE

    Lalit S Raut

    2015-01-01

    Acute myeloid leukemia (AML) treatment has always been a challenge to the treating physician. Continuous efforts are being made to improve treatment outcomes in AML. CPX-351 is a pharmacologic advancement in this direction. It is a liposomal fixed drug combination of cytarabine and daunorubicin. Early studies indicate that it will play a big role in AML treatment. This is a short review about this drug.

  15. MgA与MDS-RA细胞形态学的区别

    Institute of Scientific and Technical Information of China (English)

    安娜; 薛少青

    2009-01-01

    目的 为了提高对骨髓增生异常综合征--难治性贫血(MDS-RA)和巨幼细胞贫血(MgA)诊断与鉴别水平,对其进行细胞形态学比较.方法 对57例MDS-RA与70例MgA患者进行常规骨髓穿刺涂片,进行瑞氏染色光学显微镜下观察比较.结果 MDS-RA以双核红细胞及奇数核红细胞、淋巴样小巨核最有特征.MgA骨髓红系呈明显的"核幼质老"改变;粒系以中幼粒以下各阶段细胞巨型改变,未发现淋巴样小巨核细胞.结论 淋巴样小巨核细胞是MDS-RA主要特征.MgA骨髓细胞呈"核幼质老",并以红系为明显.

  16. A generalization of the MDS method by mixed integer linear and nonlinear mathematical models

    Directory of Open Access Journals (Sweden)

    Sadegh Niroomand

    2014-09-01

    Full Text Available The Multi-Dimensional Scaling (MDS method is used in statistics to detect hidden interrelations among multi-dimensional data and it has a wide range of applications. The method’s input is a matrix that describes the similarity/dissimilarity among objects of unknown dimension. The objects are generally reconstructed as points of a lower dimensional space to reveal the geometric configuration of the objects. The original MDS method uses Euclidean distance, for measuring both the distance of the reconstructed points and the bias of the reconstructed distances from the original similarity values. In this paper, these distances are distinguished, and distances other than Euclidean are also used, generalizing the MDS method. Two different distances may be used for the two different purposes. Therefore the instances of the generalized MDS model are denoted as  model, where the first distance is the type of distance of the reconstructed points and the second one measures the bias of the reconstructed distances and the similarity values. In the case of   and   distances mixed-integer programming models are provided. The computational experiences show that the generalized model can catch the key properties of the original configuration, if any exist. Keywords: Multivariate Analysis; Multi-Dimensional Scaling; Optimization; Mixed Integer Linear Programming; Statistics.

  17. TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia

    OpenAIRE

    Sabaawy, Hatem E.; Azuma, Mizuki; Embree, Lisa J.; Tsai, Huai-Jen; Matthew F Starost; Dennis D Hickstein

    2006-01-01

    Acute lymphoblastic leukemia (ALL) is a clonal disease that evolves through the accrual of genetic rearrangements and/or mutations within the dominant clone. The TEL-AML1 (ETV6-RUNX1) fusion in precursor-B (pre-B) ALL is the most common genetic rearrangement in childhood cancer; however, the cellular origin and the molecular pathogenesis of TEL-AML1-induced leukemia have not been identified. To study the origin of TEL-AML1-induced ALL, we generated transgenic zebrafish expressing TEL-AML1 eit...

  18. Outcome of poor response Paediatric AML using early SCT

    DEFF Research Database (Denmark)

    Wareham, Neval E; Heilmann, Carsten; Abrahamsson, Jonas;

    2013-01-01

    treated with SCT. MATERIAL AND METHODS: Treatment was given according to the NOPHO-AML 2004 protocol. All patients received AIET (Cytarabine, Idarubicin, Etoposide, Thioguanine) and AM (Cytarabine, Mitoxantrone) as induction. We included poor response defined as > 15% blasts on day 15 after AIET (n = 17......) or > 5% blasts after AM (n = 14, refractory disease). Poor response patients received intensively timed induction and proceeded to SCT when a donor was available. RESULTS: Thirty-one of 267 evaluable patients (12%) had a poor response. SCT was performed in 25; using matched unrelated donors in 13...

  19. Response properties of cat AMLS neurons to optic flow stimuli

    Institute of Scientific and Technical Information of China (English)

    LI; Baowang(李宝旺); LI; Bing(李兵); CHEN; Hui(陈辉); XU; Ying(徐颖); DIAO; Yuncheng(刁云程)

    2002-01-01

    Spiral and translation stimuli were used to investigate the response properties of cat AMLS (anteromedial lateral suprasylvian area) neurons to optic flow. The overwhelming majority of cells could be significantly excited by the two modes of stimuli and most responsive cells displayed obvious direction selectivity. It is the first time to find a visual area in mammalian brain preferring rotation stimuli. Two representative hypotheses are discussed here on the neural mechanism of optic flow analysis in visual cortex, and some new viewpoints are proposed to explain the experimental results.

  20. American experience in the implementation of AML / CFT system

    OpenAIRE

    Larin Dmitry; Popova Ekaterina

    2016-01-01

    This article presents a research into very specific matters and issues of creating and further improvement of Anti-Money Laundering and Combating the Financing of Terrorism system (abbreviated as AML/CFT) in the USA. In contains a precise analysis of key elements of this system, as well as a deep look into the nature and purposes of financial intelligence “FinCEN”. Strong emphasis is laid on The US Foreign Account Tax Compliance Act (FATCA) for the reason that, according to this Act, any fore...

  1. Valuation of transfusion-free living in MDS: results of health utility interviews with patients

    Directory of Open Access Journals (Sweden)

    Lübbert Michael

    2009-09-01

    Full Text Available Abstract Background This study measured how myelodysplastic syndrome (MDS patients value transfusion independence (TI, reduced transfusions (RT and transfusion-dependence (TD using health utility assessment methodology. Methods 47 MDS patients were interviewed, US (n = 8, France (n = 9, Germany (n = 9 and the UK (n = 21, to elicit the utility value of TI, RT and TD. Health states were developed based on literature; patient forum discussions; and were validated by a hematologist. Face-to-face interviews used the feeling thermometer Visual Analogue Scale (VAS and the Time Trade-Off (TTO method to value the health states on a 0 (dead to 1 (perfect health scale. Socio-demographic, clinical, and quality-of-life (EQ-5D characteristics were surveyed to describe the patient sample. Results and Discussion The mean age was 67 years (range: 29-83; 45% male, 70% retired; 40% had secondary/high school education, or higher (32%, and 79% lived with family, a partner or spouse, or friends. The mean time from MDS diagnosis was 5 years (range:1-23. Most patients (87% received previous transfusions and 49% had received a transfusion in the last 3 months. Mean EQ-5D index score was 0.78; patients reported at least some problem with mobility (45%, usual activities (40%, pain/discomfort (47%, and anxiety/depression (34%. Few patients had difficulty understanding the VAS (n = 3 and TTO (n = 4 exercises. Utility scores for TI were higher than for RT (0.84 vs. 0.77; p Conclusion Patients value TI, suggesting an important role for new treatments aiming to achieve greater TI in MDS. These results can be used in preference-based health economic evaluation of new MDS treatments, such as in future cost-utility studies.

  2. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis

    OpenAIRE

    Ahn, Eun-Young; Yan, Ming; Malakhova, Oxana A.; Lo, Miao-Chia; Boyapati, Anita; Ommen, Hans Beier; Hines, Robert; Hokland, Peter; Zhang, Dong-Er

    2008-01-01

    AML1-ETO is generated from t(8;21)(q22;q22), which is a common form of chromosomal translocation associated with development of acute myeloid leukemia (AML). Although full-length AML1-ETO alone fails to promote leukemia because of its detrimental effects on cell proliferation, an alternatively spliced isoform, AML1-ETO9a, without its C-terminal NHR3/NHR4 domains, strongly induces leukemia. However, full-length AML1-ETO is a major form of fusion product in many t(8;21) AML patients, suggesting...

  3. Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1.

    Directory of Open Access Journals (Sweden)

    Shinobu Tsuzuki

    2007-05-01

    Full Text Available BACKGROUND: AML1/RUNX1 is the most frequently mutated gene in leukaemia and is central to the normal biology of hematopoietic stem and progenitor cells. However, the role of different AML1 isoforms within these primitive compartments is unclear. Here we investigate whether altering relative expression of AML1 isoforms impacts the balance between cell self-renewal and differentiation in vitro and in vivo. METHODS AND FINDINGS: The human AML1a isoform encodes a truncated molecule with DNA-binding but no transactivation capacity. We used a retrovirus-based approach to transduce AML1a into primitive haematopoietic cells isolated from the mouse. We observed that enforced AML1a expression increased the competitive engraftment potential of murine long-term reconstituting stem cells with the proportion of AML1a-expressing cells increasing over time in both primary and secondary recipients. Furthermore, AML1a expression dramatically increased primitive and committed progenitor activity in engrafted animals as assessed by long-term culture, cobblestone formation, and colony assays. In contrast, expression of the full-length isoform AML1b abrogated engraftment potential. In vitro, AML1b promoted differentiation while AML1a promoted proliferation of progenitors capable of short-term lymphomyeloid engraftment. Consistent with these findings, the relative abundance of AML1a was highest in the primitive stem/progenitor compartment of human cord blood, and forced expression of AML1a in these cells enhanced maintenance of primitive potential both in vitro and in vivo. CONCLUSIONS: These data demonstrate that the "a" isoform of AML1 has the capacity to potentiate stem and progenitor cell engraftment, both of which are required for successful clinical transplantation. This activity is consistent with its expression pattern in both normal and leukaemic cells. Manipulating the balance of AML1 isoform expression may offer novel therapeutic strategies, exploitable in

  4. Erlebnisanalyse und szenisches Verstehen

    DEFF Research Database (Denmark)

    Nagbøl, Søren Peter

    2013-01-01

    Im Folgenden stelle ich einige Leitgedanken der psychoanalytischen Herme-neutik und Merkmale für die Anwendung des szenischen Verstehens heraus. Ich mache dies u.a. auch in der Absicht, meine Art und Weise, und die kon-zeptuelle vorarbeiten in der ich forsche, sichtbar zu machen und zu positionieren...

  5. Physikdidaktik Theorie und Praxis

    CERN Document Server

    Girwidz, Raimund; Häußler, Peter

    2015-01-01

    „Physikdidaktik – Theorie und Praxis“ ist ein Sammelband, der dynamisch gewachsen ist. Der Teil I wurde im Jahre 2000 in erster Linie für Studierende des Lehramts Physik konzipiert. Der Teil II zeigt Konkretisierungen und im Unterricht erprobte Beispiele zu neueren didaktischen und methodischen Ansätzen, die aus der Pädagogik und der allgemeinen Didaktik für die Physikdidaktik aufbereitet wurden. Die Physikdidaktik befasst sich natürlich auch mit der Frage, welche Elemente aus der modernen Physik in den Unterricht eingehen können und sollen. Vor der Aufbereitung der Inhalte für den Unterricht, mit Vereinfachungen und angemessenen didaktischen Reduktionen, steht die Sachanalyse und die Zusammenfassung von interessanten Themen aus aktuellen experimentellen und theoretischen Arbeitsgebieten der Physik (Teil III). In der vorliegenden 3. Ausgabe eines Gesamtbandes „Physikdidaktik – Theorie und Praxis“ wurden Astrophysik, Elementar­teilchenphysik und Biophysik als interessante Beispiele aus ...

  6. Frauen und Sucht : Literaturkompendium

    OpenAIRE

    Franke, Alexa; Mohn, Karin; Welbrink, Andrea; Witte, Maibritt; Teuber, Jutta

    2000-01-01

    Das vorliegende Literaturkompendium stellt die aktuelle wissenschaftliche Literatur zu dem Thema "Frauen und Sucht" systematisch und möglichst umfassend dar. Es beinhaltet Literaturhinweise zu frauenspezifischen Ursachen, Bedingungen, Verläufen und Folgen des Substanzmißbrauchs. Zur besseren Überschaubarkeit und um den Umfang der Recherche einzugrenzen, bezieht sich das Kompendium ausschließlich auf folgende Substanzen: Alkohol, Medikamente und illegale Drogen. Grundlage des Kompendiums ...

  7. Gesundheit, Essen und Nachhaltigkeit

    DEFF Research Database (Denmark)

    Reisch, Lucia

    2012-01-01

    Das vielschichtige Thema Ernährung ist angesichts weltweiter Ernährungskrisen sowie der Bedrohung durch den Klimawandel noch komplexer geworden: Immer deutlicher wird die wissenschaftliche Evidenz der direkten und indirekten Zusammenhänge zwischen Ernährung und Gesundheit, Energie und Klima sowie...... oder überfordern diese; hinzukommen müsse daher eine geschickte „Architektur der Wahl“, die Verhalten deutlich beeinflussen und nachhaltige Ernährungs- und Lebensstile fördern kann....

  8. Diskurs und Praxis: Geschlecht und Gewalt

    OpenAIRE

    Angela Koch

    2003-01-01

    Der Sammelband befasst sich kulturwissenschaftlich mit den Verschränkungen der diskursiven Repräsentationen von Geschlecht und Gewalt, mit deren alltäglichen Erscheinungsformen und juristischen Auslegungen. Im Vordergrund steht die personale Gewalttätigkeit als physisches Mittel des Zwangs, der Dominanz und der Macht. Der Band geht auf die Tagung „Frauen und Gewalt“ zurück, die im Oktober 2001 in Greifswald stattgefunden hat, und versammelt 18 Beiträge, die unterschiedliche Facetten des Theme...

  9. Spontaneous remission in three cases of AML M5 with NPM1 mutation

    OpenAIRE

    Camus, Vincent; Etancelin, Pascaline; Jardin, Fabrice; Lenain, Pascal; Contentin, Nathalie; Daliphard, Sylvie; Buchonnet, Gérard; Lemasle, Emilie; Lanic, Hélène; Leprêtre, Stéphane; Penther, Dominique; Dubois, Sydney; Tilly, Hervé; Bastard, Christian; Stamatoullas, Aspasia

    2015-01-01

    Key Clinical Message Patients with NPM1-mutated AML M5 who develop spontaneous remission (SR) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype. We report three cases of AML M5 patients with the same genotype that experienced transient SR and are now leukemia free after standard treatment.

  10. Spontaneous remission in three cases of AML M5 with NPM1 mutation

    Science.gov (United States)

    Camus, Vincent; Etancelin, Pascaline; Jardin, Fabrice; Lenain, Pascal; Contentin, Nathalie; Daliphard, Sylvie; Buchonnet, Gérard; Lemasle, Emilie; Lanic, Hélène; Leprêtre, Stéphane; Penther, Dominique; Dubois, Sydney; Tilly, Hervé; Bastard, Christian; Stamatoullas, Aspasia

    2015-01-01

    Key Clinical Message Patients with NPM1-mutated AML M5 who develop spontaneous remission (SR) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype. We report three cases of AML M5 patients with the same genotype that experienced transient SR and are now leukemia free after standard treatment. PMID:26576281

  11. The leukemogenic t(8;21) fusion protein AML1-ETO controls ribosomal RNA genes and associates with nucleolar organizing regions at mitotic chromosomes

    OpenAIRE

    Bakshi, Rachit; Zaidi, Sayyed K.; Pande, Sandhya; Hassan, Mohammad Q.; Young, Daniel W; Lian, Jane B.; van Wijnen, Andre J; Stein, Janet L.; Stein, Gary S.

    2008-01-01

    RUNX1/AML1 is required for definitive hematopoiesis and is frequently targeted by chromosomal translocation in acute myeloid leukemias (AML). The t(8;21) related AML1-ETO fusion protein blocks differentiation of myeloid progenitors. Here, we show by immunofluorescence microscopy that during interphase, endogenous AML1-ETO localizes to nuclear microenvironments distinct from those containing native RUNX1/AML1 protein. At mitosis, we clearly detect binding of AML1-ETO to nucleolar organizing re...

  12. The HPB-AML-I cell line possesses the properties of mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Tatsumi Eiji

    2010-12-01

    Full Text Available Abstract Background In spite of its establishment from the peripheral blood of a case with acute myeloid leukemia (AML-M1, HPB-AML-I shows plastic adherence with spindle-like morphology. In addition, lipid droplets can be induced in HPB-AML-I cells by methylisobutylxanthine, hydrocortisone, and indomethacin. These findings suggest that HPB-AML-I is similar to mesenchymal stem cells (MSCs or mesenchymal stromal cells rather than to hematopoietic cells. Methods To examine this possibility, we characterized HPB-AML-I by performing cytochemical, cytogenetic, and phenotypic analyses, induction of differentiation toward mesenchymal lineage cells, and mixed lymphocyte culture analysis. Results HPB-AML-I proved to be negative for myeloperoxidase, while surface antigen analysis disclosed that it was positive for MSC-related antigens, such as CD29, CD44, CD55, CD59, and CD73, but not for CD14, CD19, CD34, CD45, CD90, CD105, CD117, and HLA-DR. Karyotypic analysis showed the presence of complicated abnormalities, but no reciprocal translocations typically detected in AML cases. Following the induction of differentiation toward adipocytes, chondrocytes, and osteocytes, HPB-AML-I cells showed, in conjunction with extracellular matrix formation, lipid accumulation, proteoglycan synthesis, and alkaline phosphatase expression. Mixed lymphocyte culture demonstrated that CD3+ T-cell proliferation was suppressed in the presence of HPB-AML-I cells. Conclusions We conclude that HPB-AML-I cells appear to be unique neoplastic cells, which may be derived from MSCs, but are not hematopoietic progenitor cells.

  13. Prenatal origin of childhood AML occurs less frequently than in childhood ALL

    International Nuclear Information System (INIS)

    While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive. Our study aimed to screen Guthrie cards (neonatal blood spots) of non-infant childhood AML and ALL patients for the presence of their respective leukemic markers. We analysed Guthrie cards of 12 ALL patients aged 2–6 years using immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements (n = 15) and/or intronic breakpoints of TEL/AML1 fusion gene (n = 3). In AML patients (n = 13, age 1–14 years) PML/RARalpha (n = 4), CBFbeta/MYH11 (n = 3), AML1/ETO (n = 2), MLL/AF6 (n = 1), MLL/AF9 (n = 1) and MLL/AF10 (n = 1) fusion genes and/or internal tandem duplication of FLT3 gene (FLT3/ITD) (n = 2) were used as clonotypic markers. Assay sensitivity determined using serial dilutions of patient DNA into the DNA of a healthy donor allowed us to detect the pre-leukemic clone in Guthrie card providing 1–3 positive cells were present in the neonatal blood spot. In 3 patients with ALL (25%) we reproducibly detected their leukemic markers (Ig/TCR n = 2; TEL/AML1 n = 1) in the Guthrie card. We did not find patient-specific molecular markers in any patient with AML. In the largest cohort examined so far we used identical approach for the backtracking of non-infant childhood ALL and AML. Our data suggest that either the prenatal origin of AML is less frequent or the load of pre-leukemic cells is significantly lower at birth in AML compared to ALL cases

  14. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-α transcription factors

    OpenAIRE

    Zeng, Congmei; van Wijnen, André J.; Stein, Janet L.; Meyers, Shari; Sun, Wuhua; Shopland, Lindsay; Lawrence, Jeanne B.; Penman, Sheldon; Lian, Jane B.; Stein, Gary S.; Hiebert, Scott W.

    1997-01-01

    Transcription factors of the AML (core binding factor-α/polyoma enhancer binding protein 2) class are key transactivators of tissue-specific genes of the hematopoietic and bone lineages. Alternative splicing of the AML-1 gene results in two major AML variants, AML-1 and AML-1B. We show here that the transcriptionally active AML-1B binds to the nuclear matrix, and the inactive AML-1 does not. The association of AML-1B with the nuclear matrix is independent of DNA binding and requires a nuclear...

  15. Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ–CBP fusion protein

    OpenAIRE

    Kitabayashi, Issay; Aikawa, Yukiko; Nguyen, Lan Anh; Yokoyama, Akihiko; Ohki, Misao

    2001-01-01

    The AML1–CBFβ transcription factor complex is the most frequent target of specific chromosome translocations in human leukemia. The MOZ gene, which encodes a histone acetyltransferase (HAT), is also involved in some leukemia-associated translocations. We report here that MOZ is part of the AML1 complex and strongly stimulates AML1-mediated transcription. The stimulation of AML1-mediated transcription is independent of the inherent HAT activity of MOZ. Rather, a potent transactivation domain w...

  16. Improving diffusion power of AES Rijndael with 8x8 MDS matrix

    Directory of Open Access Journals (Sweden)

    R.Elumalai,

    2011-01-01

    Full Text Available AES Rijndael is a block cipher developed by NIST as the Advanced Encryption Standard (AES replacing DES and published as FIPS 197 in November 2001 [5] to address the threatened key size of Data Encryption Standard (DES. AES-Rijndael was developed by Joan Daemen and Vincent Rijmen, Rijndael [4, 5] and was selected from five finalists. Advancement in computation speed every day puts lotsof pressure on AES and AES may not with stand attack for longer time. This work focuses on improving security of an encryption algorithm, beyond AES. Though there are various techniques available to enhance the security, an attempt is made to improve the diffusion strength of an algorithm. For enhancing the diffusion power AES Rijndael in MixColumn operation the branch number of MDS matrix is raised from 5 to 9 using a new 8X8 MDS matrix with trade off of speed [8, 9] and implemented on R8C microcontroller.

  17. American experience in the implementation of AML / CFT system

    Directory of Open Access Journals (Sweden)

    Larin Dmitry

    2016-01-01

    Full Text Available This article presents a research into very specific matters and issues of creating and further improvement of Anti-Money Laundering and Combating the Financing of Terrorism system (abbreviated as AML/CFT in the USA. In contains a precise analysis of key elements of this system, as well as a deep look into the nature and purposes of financial intelligence “FinCEN”. Strong emphasis is laid on The US Foreign Account Tax Compliance Act (FATCA for the reason that, according to this Act, any foreign financial institution is legitimately forced to sign a special agreement with The US Internal Revenue Service (IRS, giving the Service power to maintain control over any American asset within its equity. The latter is understood as a legal right to investigate not only the accounts and property of American taxpayers, but to investigate any account or capital of any foreign institution having American shares or stocks.

  18. Measurement of the Mass Difference m(D_s^+) - m(D^+) at CDF II

    CERN Document Server

    Acosta, D; Ahn, M H; Akimoto, T; Albrow, M G; Alcorn, B; Alexander, C; Allen, D; Allspach, D H; Amaral, P; Ambrose, D; Amendolia, S R; Amidei, D; Amundson, J F; Anastassov, A; Anderson, J; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arguin, J F; Arisawa, T; Artikov, A; Asakawa, T; Ashmanskas, W; Attal, A; Avanzini, C; Azfar, F; Azzi-Bacchetta, P; Babik, M; Bacchetta, N; Bachacou, H; Badgett, W F; Bailey, S; Bakken, J; Barbaro-Galtieri, A; Bardi, A; Bari, M; Barker, G; Barnes, V E; Barnett, B A; Baroiant, S; Barone, M; Barsotti, E; Basti, A; Bauer, G; Beckner, D; Bedeschi, F; Behari, S; Belforte, S; Bell, W H; Bellendir, G; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Beretvas, A; Berg, B; Bhatti, A A; Binkley, M; Bisello, D; Bishai, M; Blair, R E; Blocker, C; Bloom, K; Blumenfeld, B; Bocci, A; Bodek, A; Bogdan, M; Bölla, G; Bolshov, A; Booth, P S L; Bortoletto, Daniela; Boudreau, J; Bourov, S; Bowden, M; Box, D; Bromberg, C; Brown, W; Brozovic, M; Brubaker, E; Buckley-Geer, L; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Bussey, P; Byon-Wagner, A; Byrum, K L; Cabrera, S; Calafiura, P; Campanelli, M; Campbell, M; Canal, P; Canepa, A; Carithers, W C; Carlsmith, D; Carosi, R; Carrell, K; Carter, H; Caskey, W; Castro, A; Cauz, D; Cerri, A; Cerri, C; Cerrito, L; Chandler, J T; Chapman, J; Chappa, S; Chen, C; Chen, Y C; Cheng, M T; Chertok, M; Chiarelli, G; Chirikov-Zorin, I E; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chu, M L; Chung, J Y; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Cisko, S; Clark, A G; Coca, M; Coiley, K; Colijn, A P; Colombo, R M; Connolly, A; Convery, M; Conway, J; Cooper, G; Cordelli, M; Cortiana, G; Cranshaw, J; Cudzewicz, R; Culbertson, R; Currat, C; Cyr, D; Dagenhart, D; Dal Monte, L; Da Ronco, S; D'Auria, S; Davila, R; Dawson, J; Dawson, T; De Barbaro, P; De Baun, C; De Cecco, S; Dell'Agnello, S; Dell'Orso, Mauro; De Maat, R; Demar, P; Demers, S; Demortier, L; Deninno, M; De Pedis, D; Derwent, P F; Derylo, G; Devlin, T; Dionisi, C; Dittmann, J R; Doksus, P; Dominguez, A; Donati, S; Donno, F; D'Onofrio, M; Dorigo, T; Downing, R; Drake, G; Drennan, C; Drollinger, V; Dunietz, Isard; Dyer, A; Ebina, K; Eddy, N; Ely, R; Engels, E; Erbacher, R D; Erdmann, M; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Feild, R G; Feindt, M; Fernández, J P; Ferretti, C; Field, R D; Fiori, I; Fischler, M; Flanagan, G; Flaugher, B; Flores-Castillo, L R; Foland, A D; Forrester, S; Foster, G W; Franklin, M; Frisch, H; Fromm, J; Fujii, Y; Furic, I; Galeotti, S; Galet, G; Gallas, A; Gallinaro, M; Ganel, O; García, C; García-Sciveres, M; Garfinkel, A F; Garwacki, M; Garzoglio, G; Gay, C; Gerberich, H; Gerdes, D W; Gerchtein, E; Gerstenslager, J; Giacchetti, L; Giagu, S; Giannetti, P; Gibson, A; Gillespie, G; Gingu, C; Ginsburg, C; Giolo, K; Giordani, M; Glagolev, V; Glenzinski, D A; Glossen, R; Gold, M; Goldschmidt, N; Goldstein, D B; Goldstein, J; Gómez, G; Goncharov, M; González, H; Gordon, S; Gorelov, I; Goshaw, A T; Gotra, Yu; Goulianos, K; Grado, J; Gregori, M; Gresele, A; Griffin, T; Grim, G; Grimm, C; Gromoll, S; Grosso-Pilcher, C; Gu, C; Guarino, V; Günther, M; Guimarães da Costa, J; Haber, C; Hahn, A; Hahn, K; Hahn, S R; Halkiadakis, E; Hall, C; Handler, R; Haney, M; Hao, W; Happacher, F; Hara, K; Hare, M; Harr, R F; Harrington, J; Harris, R M; Hartmann, F; Hatakeyama, K; Hauser, J; Hawke, T; Hays, C; Heider, E; Heinemann, B; Heinrich, J; Heiss, A; Hennecke, M; Herber, R; Herndon, M; Herren, M; Hicks, D; Hill, C; Hirschbuehl, D; Höcker, A; Hoff, J; Hoffman, K D; Hoftiezer, J H; Holloway, A; Holloway, L E; Holm, S; Holmgren, D; Hou, S; Houlden, M A; Howell, J; Hrycyk, M; Hubbard, P; Hughes, R E; Huffman, B T; Humbert, J; Huston, J; Ikado, K; Incandela, J R; Introzzi, G; Iori, M; Ishizawa, I; Issever, C; Ivanov, A; Iwata, Y; Iyutin, B; James, E; Jang, D; Jarrell, J; Jeans, D; Jensen, H; Jetton, R; Johnson, M; Jones, M; Jones, T; Jun, S Y; Junk, T R; Kallenbach, Jeff; Kamon, T; Kang, J; Karagoz-Unel, M; Karchin, P E; Kartal, S; Kasha, H; Kasten, M; Kato, Y; Kemp, Y; Kennedy, R D; Kephart, K; Kephart, R D; Khazins, D; Khotilovich, V; Kilminster, B; Kim, B J; Kim, D H; Kim, H S; Kim, J; Kim, M J; Kim, M S; Kim, S B; Kim, S H; Kim, T H; Kim, Y K; King, B T; Kirby, M; Kirk, M; Kirsch, L; Klein, R; Klimenko, S; Knapp, M; Knoblauch, D; Knuteson, B; Kobayashi, H; Koehn, P; Kondo, K; Kong, D J; Konigsberg, J; Kononenko, W; Kordas, K; Korn, A J; Korytov, A; Kotelnikov, K A; Kotwal, A; Kovalev, A; Kowalkowski, J B; Kraus, J; Kravchenko, I V; Kreymer, A; Kroll, J; Kruse, M; Krutelyov, V; Kuhlmann, S E; Kumar, A; Kuznetsova, N; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lamore, D; Lancaster, J; Lancaster, M; Lander, R; Lanfranco, G; Lannon, K; Lath, A; Latino, G; Lauhakangas, R; Lazzizzera, I; Le, Y; LeCompte, T J; Lee, J; Lee, K; Lee, S W; Lei, C M; Leininger, M; Leonardi, G L; Leonardo, N; Leone, S; Levshina, T; Lewis, F; Lewis, J D; Li, K; Lin, C S; Lindgren, M; Liss, T M; Litvintsev, D O; Liu, T; Liu, Y; Lobban, O; Lockyer, N S; Loginov, A; Loken, J; Loreti, M; Loskot, J; Loverre, P F; Lucchesi, D; Lukens, P; Lutz, P; Lyons, L; Lys, J; MacNerland, J; MacQueen, D; Madorsky, A; Madrak, R; Maeshima, K; Maksimovic, P; Malferrari, L; Mammini, P; Manca, G; Mandrichenko, I V; Manea, C; Marginean, R; Marrafino, J; Martin, A; Martin, M; Martin, V; Martínez, M; Maruyama, T; Matsunaga, H; Mayer, J; Mayers, G M; Mazzanti, P; McFarland, K S; McGivern, D; McIntyre, P M; McNamara, P; McNulty, R; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Meyer, A; Miao, T; Michael, N; Miller, J S; Miller, L; Miller, R; Miquel, R; Miscetti, S; Mitselmakher, G; Miyamoto, A; Miyazaki, Y; Mizicko, D; Moccia, S; Moggi, A; Moggi, N; Montero, S; Moore, R; Moore, T; Morris, L; Morsani, F; Moulik, T; Mukherjee, A; Mulhearn, M; Müller, T; Mumford, R; Munar, A; Murat, P; Murgia, S; Nachtman, J; Nagaslaev, V; Nahn, S; Nakamura, I; Nakano, I; Napier, A; Napora, R; Necula, V; Nelson, C; Nelson, T; Neu, C; Neubauer, M S; Neuberger, D; Newby, W; Newcomer, F M; Newman-Holmes, C; Niell, F; Nielsen, J; Nicollerat, A S; Nigmanov, T; Niu, H; Nodulman, L; Noe, W; Österberg, K; Ogawa, T; Oh, S; Oh, Y D; Ohl, K; Ohsugi, T; Oishi, R; Okusawa, T; Oldeman, R G C; Orava, Risto; Orejudos, W; Orr, S; Pagani, G; Pagliarone, C; Palmonari, F; Ramos, I; Panacek, S; Pantano, D; Paoletti, R; Papadimitriou, V; Pasetes, R; Pashapour, S; Passuello, D; Paterno, M; Patrick, J; Pauletta, G; Paulini, M; Pauly, T; Paus, C; Pavlicek, V; Pavlon, S; Pellett, D; Penzo, Aldo L; Perington, B; Petragnani, G; Petravick, D; Phillips, T J; Photos, F; Piacentino, G; Picciolo, C; Piccoli, L; Piedra, J; Pitts, K T; Plunkett, R; Pompos, A; Pondrom, L; Pope, G; Poukhov, O; Prakoshyn, F; Pratt, T; Profeti, A; Pronko, A G; Proudfoot, J; Punzi, G; Rademacker, J; Rafaelli, F; Rakitine, A; Rappoccio, S; Ratnikov, F; Rauch, J; Ray, H; Rechenmacher, R; Reia, S; Reichold, A; Rekovic, V; Renton, P B; Rescigno, M; Rimondi, F; Rinnert, K; Ristori, L; Riveline, M; Rivetta, C; Robertson, W J; Robson, A; Rodrigo, T; Rolli, S; Román, M; Rosenberg, S I; Rosenson, L; Roser, R; Rossin, R; Rott, C; Ruiz, A; Russ, J; Ryan, D; Saarikko, H; Sabik, S; Sadler, L; Safonov, A; Saint-Denis, R; Sakumoto, W K; Saltzberg, D; Sánchez, C; Sanders, H; Sanders, R; Sandrew, M; Sansoni, A; Santi, L; Sarkar, S; Sarraj, H; Sarraj, J; Sato, H; Savard, P; Schemitz, P; Schlabach, P; Schmidt, E E; Schmidt, J; Schmidt, M P; Schmitt, M; Schmitt, R; Schmitz, M; Schofield, G L; Schuh, K; Schultz, K; Scodellaro, L; Scott, L; Scribano, A; Scuri, F; Sedov, A; Segler, S; Seidel, S; Seiya, Y; Semenov, A; Semeria, F; Sexton-Kennedy, L; Sfiligoi, I; Shallenberger, J; Shapiro, M D; Shaw, T; Shears, T G; Shenai, A; Shepard, P F; Shimojima, M; Shochet, M J; Shon, Y; Shoun, M; Sidoti, A; Siegrist, J L; Sieh, C; Siket, M; Sill, A; Silva, R; Simaitis, V; Sinervo, P; Sirotenko, V I; Sissakian, A N; Skiba, A; Slaughter, A J; Sliwa, K; Smith, J; Snider, F D; Snihur, R; Somalwar, S V; Spalding, J; Spezziga, M; Spiegel, L; Spinella, F; Spiropulu, M; Stadie, H; Stanek, R; Stanfield, N; Stelzer, B; Stelzer-Chilton, O; Strologas, J; Stuart, D; Stuermer, W; Sukhanov, A; Sumorok, K; Sun, H; Suzuki, T; Syu, J; Szymulanski, A; Taffard, A C; Takach, S F; Takano, H; Takashima, R; Takeuchi, Y; Takikawa, K; Tamburello, P; Tanaka, M; Tanaka, R; Tang, D; Tanimoto, N; Tannenbaum, B; Tapprogge, Stefan; Taylor, R D; Teafoe, G; Tecchio, M; Teng, P K; Terashi, K; Terentieva, T; Tesarek, R J; Tether, S; Thom, J; Thomas, A; Thompson, A S; Thomson, E; Thurman-Keup, R M; Timm, S; Tipton, P; Tkaczyk, S M; Toback, D; Tollefson, K; Tonelli, D; Tonnesmann, M; Torretta, D; Trimby, C; Trischuk, W; Trumbo, J; Tseng, J; Tsuchiya, R; Tsuno, S; Tsybychev, D; Turini, N; Turner, M; Ukegawa, F; Unverhau, T; Uozumi, S; Usynin, D; Vacavant, L; Vaiciulis, T; Van Berg, R; Varganov, A V; Vataga, E; Vejcik, S; Velev, G V; Veramendi, G; Vickey, T; Vidal, R; Vila, I; Vilar, R; Vittone, M; Voirin, J; Vollmer, B; Vollrath, I; Volobuev, I P; Von der Mey, M; Votava, M; Wagner, R G; Wagner, R L; Wagner, W; Wallace, N; Walter, T; Walters, A; Wan, Z; Wandersee, A; Wang, M J; Wang, S M; Ward, B; Waschke, S; Waters, D; Watts, T; Weber, M; Weems, L; Wenzel, H; Wester, W; Whitehouse, B; Wickenberg, W; Wicklund, A B; Wicklund, E; Wigmans, R; Wike, C; Wilkes, T; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolter, M; Wong, M; Worcester, M; Worland, R; Worm, S; Wright, T; Wu, J; Wu, X; Würthwein, F; Wyatt, A; Yagil, A; Yamamoto, K; Yamashita, T; Yang, U K; Yao, W; Yarema, R J; Yeh, G P; Yi, K; Yocum, D R; Yoh, J K; Yoon, P; Yorita, K; Yoshida, T; Yu, I; Yu, S; Yu, Z; Yun, J C; Zalokar, M; Zanello, L; Zanetti, A; Zaw, I; Zetti, F; Zhou, J; Zimmerman, T; Zsenei, A; Zucchelli, S

    2003-01-01

    We present a measurement of the mass difference m(D+_s) - m(D+), where both the D+_s and D+ are reconstructed in the phi pi+ decay channel. This measurement uses 11.6 pb-1 of data collected by CDF II using the new displaced-track trigger. The mass difference is found to be: 99.41 +- 0.38 (stat) +- 0.21 (syst) MeV/c^2.

  19. Optimal Repair of MDS Codes in Distributed Storage via Subspace Interference Alignment

    CERN Document Server

    Cadambe, Viveck R; Jafar, Syed A; Li, Jin

    2011-01-01

    It is well known that an (n,k) code can be used to store 'k' units of information in 'n' unit-capacity disks of a distributed data storage system. If the code used is maximum distance separable (MDS), then the system can tolerate any (n-k) disk failures, since the original information can be recovered from any k surviving disks. The focus of this paper is the design of a systematic MDS code with the additional property that a single disk failure can be repaired with minimum repair bandwidth, i.e., with the minimum possible amount of data to be downloaded for recovery of the failed disk. Previously, a lower bound of (n-1)/(n-k) units has been established by Dimakis et. al, on the repair bandwidth for a single disk failure in an (n,k) MDS code . Recently, the existence of asymptotic codes achieving this lower bound for arbitrary (n,k) has been established by drawing connections to interference alignment. While the existence of asymptotic constructions achieving this lower bound have been shown, finite code cons...

  20. Magie, Hexen und Strafverfolgung

    Directory of Open Access Journals (Sweden)

    Arne Duncker

    2008-07-01

    Full Text Available In der Reihe „Historische Einführungen“ des Campus Verlags versucht Johannes Dillinger, die Entwicklung von Magie- und Hexereivorstellungen vom Mittelalter bis zur Gegenwart zu beschreiben. Die Hexenverfolgungen und -prozesse der Frühen Neuzeit und ihre Voraussetzungen nehmen dabei etwas mehr als die Hälfte der Gesamtdarstellung ein. Das Buch bietet in erster Linie eine Einführung in die neuere und neueste Sekundärliteratur und die dort besprochenen aktuellen Streitpunkte. In einem Teilabschnitt wird auch auf die Hexenverfolgung als Frauenverfolgung eingegangen und nach Ursachen für den hohen Frauenanteil unter den Verfolgten geforscht.

  1. Anerkennung und soziale Ungleichheit

    Directory of Open Access Journals (Sweden)

    Annegret Ergenzinger

    2008-11-01

    Full Text Available Vor dem Hintergrund der Honneth’schen Stufentheorie der Anerkennung (von der Liebe in den Paar- und Nahbeziehungen über Achtung als Gleiche in den rechtlichen Bezügen des Staates, bis hin zur sozialen Wertschätzung von Leistung in der Wertegemeinschaft werden Anerkennung und Ungleichheit in Paarbeziehungen, Arbeitsorganisationen und im Sozialstaat empirisch und/oder analytisch im vorliegenden Sammelband untersucht. Empirische und theoretische Studien zeigen, dass die Kategorie Anerkennung in der sozialen Ungleichheitsforschung neue Erkenntnisse möglich macht. Dies gilt jedoch auch umgekehrt: Die Einbeziehung von weiteren historisch-kulturell eingebetteten Kategorien der Ungleichheit kontextualisieren und differenzieren die Theorie der Anerkennung.

  2. The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis

    International Nuclear Information System (INIS)

    Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents are urgently required which can overcome drug resistance whilst avoiding unnecessary toxicity. Among newer targeted agents, both tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and proteasome inhibitors show particular promise. In this report we show that a combination of the proteasome inhibitor bortezomib and TRAIL is effective against AML cell lines, in particular, AML cell lines displaying myelomonocytic/monocytic phenotype (M4/M5 AML based on FAB classification), which account for 20-30% of AML cases. We show that the underlying mechanism of sensitization is at least in part due to bortezomib mediated downregulation of c-FLIP and XIAP, which is likely to be regulated by NF-κB. Blockage of NF-κB activation with BMS-345541 equally sensitized myelomonocytic AML cell lines and primary AML blasts to TRAIL

  3. Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.

    Science.gov (United States)

    Wong, Terrence N; Miller, Christopher A; Klco, Jeffery M; Petti, Allegra; Demeter, Ryan; Helton, Nichole M; Li, Tiandao; Fulton, Robert S; Heath, Sharon E; Mardis, Elaine R; Westervelt, Peter; DiPersio, John F; Walter, Matthew J; Welch, John S; Graubert, Timothy A; Wilson, Richard K; Ley, Timothy J; Link, Daniel C

    2016-02-18

    There is interest in using leukemia-gene panels and next-generation sequencing to assess acute myelogenous leukemia (AML) response to induction chemotherapy. Studies have shown that patients with AML in morphologic remission may continue to have clonal hematopoiesis with populations closely related to the founding AML clone and that this confers an increased risk of relapse. However, it remains unknown how induction chemotherapy influences the clonal evolution of a patient's nonleukemic hematopoietic population. Here, we report that 5 of 15 patients with genetic clearance of their founding AML clone after induction chemotherapy had a concomitant expansion of a hematopoietic population unrelated to the initial AML. These populations frequently harbored somatic mutations in genes recurrently mutated in AML or myelodysplastic syndromes and were detectable at very low frequencies at the time of AML diagnosis. These results suggest that nonleukemic hematopoietic stem and progenitor cells, harboring specific aging-acquired mutations, may have a competitive fitness advantage after induction chemotherapy, expand, and persist long after the completion of chemotherapy. Although the clinical importance of these "rising" clones remains to be determined, it will be important to distinguish them from leukemia-related populations when assessing for molecular responses to induction chemotherapy. PMID:26631115

  4. The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Dijk, Marianne van; Murphy, Eoin [Apoptosis Research Center, National University of Ireland, University Road, Galway (Ireland); School of Natural Sciences, National University of Ireland, University Road, Galway (Ireland); Morrell, Ruth [Apoptosis Research Center, National University of Ireland, University Road, Galway (Ireland); School of Natural Sciences, National University of Ireland, University Road, Galway (Ireland); School of Medicine, National University of Ireland, University Road, Galway (Ireland); Knapper, Steven [Department of Haematology, School of Medicine, Cardiff University, Heath Park, CF14 4XN Cardiff (United Kingdom); O' Dwyer, Michael [Apoptosis Research Center, National University of Ireland, University Road, Galway (Ireland); School of Medicine, National University of Ireland, University Road, Galway (Ireland); Samali, Afshin; Szegezdi, Eva, E-mail: eva.szegezdi@nuigalway.ie [Apoptosis Research Center, National University of Ireland, University Road, Galway (Ireland); School of Natural Sciences, National University of Ireland, University Road, Galway (Ireland)

    2011-03-15

    Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents are urgently required which can overcome drug resistance whilst avoiding unnecessary toxicity. Among newer targeted agents, both tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and proteasome inhibitors show particular promise. In this report we show that a combination of the proteasome inhibitor bortezomib and TRAIL is effective against AML cell lines, in particular, AML cell lines displaying myelomonocytic/monocytic phenotype (M4/M5 AML based on FAB classification), which account for 20-30% of AML cases. We show that the underlying mechanism of sensitization is at least in part due to bortezomib mediated downregulation of c-FLIP and XIAP, which is likely to be regulated by NF-κB. Blockage of NF-κB activation with BMS-345541 equally sensitized myelomonocytic AML cell lines and primary AML blasts to TRAIL.

  5. MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML.

    Science.gov (United States)

    Sauer, Tim; Arteaga, Maria Francisca; Isken, Fabienne; Rohde, Christian; Hebestreit, Katja; Mikesch, Jan-Henrik; Stelljes, Matthias; Cui, Chunhong; Zhou, Fengbiao; Göllner, Stefanie; Bäumer, Nicole; Köhler, Gabriele; Krug, Utz; Thiede, Christian; Ehninger, Gerhard; Edemir, Bayram; Schlenke, Peter; Berdel, Wolfgang E; Dugas, Martin; Müller-Tidow, Carsten

    2015-09-01

    Chromatin-modifying enzymes are frequently altered in acute myeloid leukemia (AML). In the current study, we identified MYST2, a core histone acetyltransferase, to be suppressed in blast cells from AML patients compared with nonmalignant hematopoietic progenitor cells. Functionally, loss of MYST2 accelerated leukemic growth and colony formation, while forced expression of MYST2 induced H4K5 acetylation (H4K5Ac) and suppressed hematopoietic progenitor cell growth. Consistently, global H4K5Ac levels were frequently decreased in AML blasts. Low levels of H4K5Ac were most prominent in patients with complex karyotype AML and were associated with inferior overall survival in univariate but not multivariate analysis. ChIP-seq experiments in primary AML patients' blasts revealed widespread H4K5Ac deregulation, most prominent at gene promoters. Taken together, MYST2 is a repressed growth suppressor in AML mediating reduced acetylation of histone 4 at residue 5 and is associated with inferior AML patient survival. PMID:26072331

  6. Wissenschaft und Wiedervereinigung - Bilanz und offene Fragen

    OpenAIRE

    Ash, Mitchell G.; Bierwisch, Manfred; Erhardt, Manfred; Ganten, Detlev; Grübel, Hartmut F.; Hertel, Ingolf; Kern, Horst F.; Klein, Dieter; Kocka, Jürgen; Krull , Wilhelm; Kuczynski, Thomas; Laitko, Hubert; Malycha, Andreas; Mayntz, Renate; Meyer, Hans Joachim

    2010-01-01

    Im 20. Jahr nach dem Mauerfall fand in der Berlin-Brandenburgischen Akademie der Wissenschaften vom 24. bis 25. November 2009 das Symposium „Wissenschaft und Wiedervereinigung. Bilanz und offene Fragen“ statt. Im Rahmen des Wissenschaftsjahres 2009 diskutierten Wissenschaftler und Wissenschaftspolitiker, ob bei der Vereinigung der beiden deutschen Wissenschaftssysteme Chancen genutzt oder verpasst wurden. Wie unterschiedlich oder ähnlich entwickelten sich die beiden getrennten Systeme bis zum...

  7. Energie- und Ressourceneffizienz in der Wärmebehandlung und Thermoprozesstechnik

    OpenAIRE

    Fritsching, Udo

    2012-01-01

    Die effiziente Nutzung von Energie und Rohstoffen gewinnt in den allen Produktionsprozessen zunehmend an Bedeutung. Steigende Energiepreise und Umweltanforderungen sowie der zunehmende Kostendruck durch die Globalisierung zwingen auch klein- und mittelständische Unternehmen, sich mit dem Thema Energie- und Ressourceneffizienz verstärkt auseinanderzusetzen. Potentielle Effizienzsteigerungen in Prozessen und Anlagen gründen nach dem Stand der Technik auf innovativen Prozessen und Produkten und ...

  8. Angiomyolipoma (AML) without visible fat: Ultrasound, CT and MR imaging features with pathological correlation

    Energy Technology Data Exchange (ETDEWEB)

    Hakim, Shaheed W.; Flood, Trevor A. [The Ottawa Hospital, University of Ottawa, Department of Anatomical Pathology, Ottawa, Ontario (Canada); Schieda, Nicola; Hodgdon, Taryn; McInnes, Matthew D.F.; Dilauro, Marc [The Ottawa Hospital, University of Ottawa, Department of Medical Imaging, Ottawa, Ontario (Canada)

    2016-02-15

    To compare imaging findings with histopathology in AML without visible fat (AML{sub wvf}). With IRB approval, we identified 18 AML{sub wvf} that underwent CT between 2002-2014. A radiologist measured NECT-attenuation, corticomedullary (CM) and nephrographic (NG) enhancement, echogenicity relative to renal cortex (RC) (N = 5), T2W (T2{sub AML}/T2{sub RC}) signal-intensity (SI), and chemical-shift SI ([SI{sub IN-PHASE} - SI{sub OPPOSED-PHASE}]/SI{sub IN-PHASE}) indices (N = 6). A pathologist re-evaluated 15/18 AML{sub wvf} for 1) < or > 25 % adipocytes/high-power-field (HPF), 2) ''many or few'' blood vessels. Comparisons were performed using chi-square and independent t-tests. 73.3 %(11/15) of AML{sub wvf} had <25 % adipocytes/HPF and 86.7 %(13/15) had ''many'' blood vessels. NECT-attenuation was 41.8(±6.9) HU. 61.1 %(11/18) of AML{sub wvf} were hyper-attenuating and 38.9 %(7/18) iso-attenuating; attenuation was associated with %-adipocytes/HPF, (p = 0.01). CM/NG enhancement were 63.3(±20.8)/51.7(±15.5) HU. 72.2 %(13/18) of AML{sub wvf} had wash-out enhancement, with no association with amount of blood vessels at pathology, (p = 0.68). No difference in echogenicity was noted by histology (p > 0.05). All AML{sub wvf} were T2-hypointense (SI ratio = 0.61 [±0.1]). 2/6 AML{sub wvf} showed SI drop on chemical-shift MRI; both were iso-attenuating and were associated with >25 % adipocytes/HPF (p = 0.04). AML{sub wvf} are typically T2-hypointense and hyper-attenuating with wash-out enhancement due to abundant smooth muscle and vessels respectively. Iso-attenuating AML{sub wvf} with microscopic fat on MRI contain more adipocytes/HPF. (orig.)

  9. Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.

    OpenAIRE

    Miyoshi, H; Ohira, M; Shimizu, K; Mitani, K; Hirai, H; Imai, T.; Yokoyama, K.; Soeda, E; Ohki, M

    1995-01-01

    We previously isolated the AML1 gene, which is rearranged by the t(8;21) translocation in acute myeloid leukemia. The AML1 gene is highly homologous to the Drosophila segmentation gene runt and the mouse transcription factor PEBP2 alpha subunit gene. This region of homology, called the Runt domain, is responsible for DNA-binding and protein--protein interaction. In this study, we isolated and characterized various forms of AML1 cDNAs which reflect a complex pattern of mRNA species. Analysis o...

  10. Strahlungsmessung und Dosimetrie

    CERN Document Server

    Krieger, Hanno

    2013-01-01

    „Strahlungsquellen und Dosimetrie“ ist Teil einer Lehrbuchreihe zur Strahlungsphysik und zum Strahlenschutz. Der erste Teil befasst sich mit den physikalischen Grundlagen der Strahlungsdetektoren und der Strahlungsmessung. Im zweiten Teil werden die Konzepte und Verfahren der klinischen Dosimetrie dargestellt. Der dritte Abschnitt erläutert ausführlich die Dosisverteilungen der klinisch angewendeten Strahlungsarten. Im vierten Teil werden weitere Messaufgaben der Strahlungsphysik einschließlich der Messsysteme für die Bildgebung mit Röntgenstrahlung dargestellt. Neben den grundlegenden Ausführungen enthält dieser Band im laufenden Text zahlreiche Tabellen und Grafiken zur technischen und medizinischen Radiologie, die bei der praktischen Arbeit sehr hilfreich sein können und 199 Übungsaufgaben mit Lösungen zur Vertiefung der Inhalte. Für die zweite Auflage wurden die Darstellungen der Elektronen- und der Protonendosimetrie sowie der bildgebenden Verfahren mit Computertomografen deutlich erweit...

  11. Globalisierung und (politische) Bildung

    OpenAIRE

    Wilkiewicz, Zbigniew

    2006-01-01

    Der Autor skizziert zu Beginn die Bestandteile und Theoriekonzepte der Globalisierung sowie ihre Folgen für Umwelt, Wirtschaft, Staat, Gesellschaft und Kultur. Er diskutiert im Anschluss daran die Frage, ob eine alternative politische Bildung ein Gegengewicht zur neoliberalen Globalisierung darstellen kann. Er listet hierzu überblicksartig verschiedene Ansatzpunkte und Kernthemen aus der Pädagogik auf und weist vor allem auf die Bedeutung des globales Lernens hin. Er betont abschließend, dass...

  12. Informationskompetenz und Information Literacy

    OpenAIRE

    Ingold, Marianne

    2012-01-01

    Informationskompetenz ist heute als Begriff , Konzept und praktisches Tätigkeitsfeld von Bibliotheken weltweit etabliert. Entstehung, Verbreitung und Entwicklung von „Informationskompetenz“ im deutschsprachigen Raum stehen in engem Zusammenhang mit dem in den USA und international seit den 1980er Jahren diskutierten und praktisch umgesetzten Konzept der „Information Literacy“. Auch wenn die beiden Begriffe in der Regel gleichbedeutend verwendet werden, zeigt ein Vergleich der vorwiegend aus e...

  13. HACCP Reproduktion und Geburt

    OpenAIRE

    Früh, Barbara; Dippel, Sabine; Leeb, Christine

    2011-01-01

    Ein Ergebnis des COREPIG-Projektes sind HACCPbasierte Managementhilfen (Hazard Analysis Critical Control Points). Diese Hilfen unterstützen Landwirte betriebsspezifisch bei der Lösung und Vorbeugung von Problemen mit Endoparasiten, Problemen der Reproduktion und rund um die Geburt, bei Absetzdurchfall und Saugferkelsterblichkeit. Sie sind in Form von Microsoft Excel®-Dateien verfügbar. Es wird empfohlen, die Hilfen zusammen mit der Beraterin und/oder dem Veterinär anzuwenden. Jede Manag...

  14. Demografie und politischer Reduktionismus

    OpenAIRE

    Kreitsch, Thomas

    2015-01-01

    Die Dissertation mit dem Thema „Demografie und politischer Reduktionismus – eine Diskursanalyse der Demografiepolitik in Deutschland“ knüpft an die Debatte um die Demografisierung an, die sich damit beschäftigt, dass gesellschaftliche Entwicklungen häufig zu sehr aus einer demografischen Perspektive betrachtet und beschrieben werden. Sie analysiert die zum Teil noch jungen Diskurse, die durch Akteure in Wissenschaft, Politik und Publizistik zu den demografiepolitischen Strategien und Aktivitä...

  15. Digital Zeichnen und Malen

    Directory of Open Access Journals (Sweden)

    Christoph Kaindel

    2013-12-01

    Full Text Available Digitales Zeichnen und Malen hat gegenüber dem „analogen“ Vorteile wie auch Nachteile. In der folgenden, unvollständigen Liste stelle ich die technischen Vor- und Nachteile, die mir aufgefallen sind, gegenüber. Kommentare und Ergänzungen sind willkommen!

  16. Timothy Ley, M.D., Advocates for Personalized Medicine in AML - TCGA

    Science.gov (United States)

    Oncologist Dr. Timothy Ley talks about how repurposing of existing drugs based on better understanding of the genetic basis of acute myeloid leukemia (AML) can help patients receive personalized care.

  17. What If the Leukemia Doesn't Respond or Comes Back After Treatment? (AML)

    Science.gov (United States)

    ... your doctor about acute myeloid leukemia? What if acute myeloid leukemia doesn’t respond or comes back after treatment? For most types of acute myeloid leukemia If acute myeloid leukemia (AML) doesn’t go ...

  18. An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

    OpenAIRE

    T. Tanaka; Tanaka, K; Ogawa, S.; M. Kurokawa; Mitani, K; Nishida, J; Shibata, Y; Yazaki, Y.; Hirai, H

    1995-01-01

    The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) and (3;21)(q26;q22) translocations associated with myelogenous leukemias and encodes a DNA binding protein. From the AML1 gene, two representative forms of proteins, AML1a and AML1b, are produced by alternative splicing. Both forms have a DNA binding domain but, unlike AML1b, AML1a lacks a putative transcriptional activation domain. Here we demonstrate that overexpressed AML1a totally suppresses granulocytic differentiation an...

  19. Improved Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) of Affinity Maturated and Fc-Engineered Antibodies Directed Against the AML Stem Cell Antigen CD96

    OpenAIRE

    Mohseni Nodehi, Sahar

    2011-01-01

    Regardless of progress in the therapy of AML, there is no long-term cure for about 70% of AML patients. Leukemic stem cells seem to be an important key for the perpetuation of AML.Most currently used chemotherapeutic agents are not able to eliminate AML-LSCs. The combination of conventional therapies with AML-LSCs-directed therapies may eventually lead to a cure for AML patients.Recently expression of CD96 was reported on AML-LSCs, while only very low expression levels were found on normal HS...

  20. Beerdigung und Feuerbestattung in Bibel und Talmud

    OpenAIRE

    Wiener, Adolf

    2008-01-01

    Fortsetzung des Aufsatzes u.d.T. "Beerdigung und Feuerbestattung in der Bibel / Schlußartikel von Rabbiner Dr. Wiener in Oppeln" s.a. http://edocs.ub.uni-frankfurt.de/volltexte/2008/9890/ Erwiderung "Die Erd- und Feuerbestattung / von Rabbiner Dr. Kohn in Inowrazlaw" s.a. http://edocs.ub.uni-frankfurt.de/volltexte/2008/9877/

  1. Jersey: Financial Sector Assessment Program Update: Detailed Assessment of Observance of AML/CFT

    OpenAIRE

    International Monetary Fund

    2009-01-01

    Jersey has put in place a comprehensive and robust Antimoney Laundering/Combating the Financing of Terrorism (AML/CFT) legal framework with a high level of compliance with almost all aspects of the Financial Action Task Force recommendations. The paper discusses a Detailed Assessment of Observance of AML/CFT report on Jersey. Both money laundering and financing of terrorism are criminalized largely in line with the international standard, and Jersey has implemented the provisions effectively.

  2. Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains

    OpenAIRE

    Zeng, Congmei; McNeil, Sandra; Pockwinse, Shirwin; Nickerson, Jeffrey; Shopland, Lindsay; Lawrence, Jeanne B.; Penman, Sheldon; Hiebert, Scott; Lian, Jane B.; van Wijnen, André J.; Stein, Janet L.; Stein, Gary S.

    1998-01-01

    The AML/CBFα runt transcription factors are key regulators of hematopoietic and bone tissue-specific gene expression. These factors contain a 31-amino acid nuclear matrix targeting signal that supports association with the nuclear matrix. We determined that the AML/CBFα factors must bind to the nuclear matrix to exert control of transcription. Fusing the nuclear matrix targeting signal to the GAL4 DNA binding domain transactivates a genomically integrated GAL4 responsive reporter gene. These ...

  3. Forholdet mellom aml. § 14-12 og direktiv 2008/104/EC art. 4

    OpenAIRE

    Trovåg, Kristin

    2015-01-01

    Masteroppgaven omhandler forholdet mellom aml. § 14-12 og direktiv 2008/104/EC art. 4 (vikarbyrådirektivet). Problemstillingen er om begrensningene for innleie av arbeidskraft fra bemanningsforetak i aml. § 14-12 første ledd er i overenstemmelse med de restriksjoner som lovlig kan begrunnes og gjennomføres etter vikarbyrådirektivet art. 4 nr. 1.

  4. How mRNA is misspliced in acute myelogenous leukemia (AML)?

    OpenAIRE

    Mohamed, Aminetou Mint; Thénoz, Morgan; Solly, Françoise; Balsat, Marie; Mortreux, Franck; Wattel, Eric

    2014-01-01

    Approximately one-third of expressed genes are misspliced in AML, opening the possibility that additional factors than splicing factor mutations might cause RNA missplicing in these diseases. AML cells harbor a constellation of epigenetic modifications and regularly express large amounts of WT1 transcripts. Histone acetylation/methylation and DNA CpG methylation favor either exon skipping or inclusion, mainly through interfering with RNA Pol II-mediated elongation. This can result either from...

  5. Cognitive distortions based on MDS configuration and sketch mapping: a case study in Beijing

    Science.gov (United States)

    Shen, Si; Xue, Lulu; Wu, Lun; Liu, Yu

    2007-06-01

    As an emerging field, cognitive map kept playing a significant role in geography these decades. To date, there are two dominant methods to externalize human's internal cognitive map, namely, multidimensional scaling (MDS) and skech mapping. However, among most recent researches on cognitive map, the differences between both methods are always ignored. The usage of one method over another is still under scrutiny. In order to shed light on the similarity or distinctions of MDS configuration and sketch mapping, we conducted an experiment on Beijing residents by requesting a sketch of the region within 3rd Ring and meanwhile extracting distance estimates between 8 landmarks. Employing the Bidimensional regression along with standard deviational ellipse, we studied the global and local distortions among two kinds of cognitive maps and quantitatively measure the overall and local cognitive maps distortions. Besides, we use Monte Carlo simulation method to calculate the radius of distortion for the Distortion Index (DI). It shows that the average cognitive distortion of habitants in Beijing is 2km to 3km, and the distortion takes 2nd-ring road as a border, displaying a southwest-northeast diagonal stretch and an east-west contracted tendency. The distortion in the two methods is remarkably both correlated with factors, such as travel frequency and years of residence. Comparing two methods, it turned out that sketch map was more consistent with real map, while the distortion orientations of sketch map resembled MDS configuration. Finally, we gave possible reasons with regard to above conclusions and advices for future usage of two methods.

  6. Auslandsadoptionen - Forschungsstand und Folgerungen

    OpenAIRE

    Textor, Martin R.

    1991-01-01

    Die Übersicht über deutsch- und englischsprachige Studien über Auslandsadoptionen enthält Angaben über Schichtzugehörigkeit und Motive der Adoptiveltern, das Familienklima und die Eltern-Kind-Beziehungen. Auch werden Forschungsergebnisse über die gesundheitliche, körperliche, sprachliche, schulische, soziale und Persönlichkeitsentwicklung ausländischer Adoptivkinder referiert. Ferner wird über den Adoptionserfolg und über Verhaltensauffälligkeiten dieser Kinder berichtet. Schließlich werden K...

  7. Ting, Twitter und Tablet

    OpenAIRE

    Schabos, Julia

    2014-01-01

    In der Leseförderung spielen klassische Medien eine wesentliche Rolle, werden aber zunehmend durch digitale Angebote ergänzt. Das Projekt „Lesen macht stark: Lesen und digitale Medien“ greift diese Entwicklung auf. Es bietet Bibliotheken mit fünf altersgerechten Aktionen die Gelegenheit, bewährte Veranstaltungsformate digital anzureichern und cross-medial zu arbeiten, denn Text- und Medienkompetenz sind wesentliche Voraussetzungen für die Meinungs- und Persönlichkeitsbildung von Kindern und J...

  8. Gold und Peanuts

    OpenAIRE

    Hashmi, Stephen

    2003-01-01

    Die bisherigen Kenntnisse zur Gold-Katalyse lassen sich wie folgt zusammenfassen: 1. Gold-Katalysatoren reagieren rasch mit Kohlenstoff-Kohlenstoff-Mehrfachbindungen und sind somit besonders für einen Einsatz in der Organischen Chemie,der Chemie des Kohlenstoffs, geeignet. Dies lässt sich damit erklären, dass Gold und Kohlenstoff gemäß des Prinzips der harten und weichen Säuren und Basen („hard and soft acids and bases“, HSABPrinzip)beide als „weich“ klassifiziert werden und dieses Prinzi...

  9. The DVB Channel Coding Application Using the DSP Development Board MDS TM-13 IREF

    Directory of Open Access Journals (Sweden)

    M. Slanina

    2004-12-01

    Full Text Available The paper deals with the implementation of the channel codingaccording to DVB standard on DSP development board MDS TM-13 IREF andPC. The board is based on Philips Nexperia media processor andintegrates hardware video ADC and DAC. The program libraries featuresused for MPEG based video compression are outlined and then thealgorithms of channel decoding (FEC protection against errors arepresented including the flowchart diagrams. The paper presents thepartial hardware implementation of the simulation system that coversselected phenomena of DVB baseband processing and it is used for realtime interactive demonstration of error protection influence ontransmitted digital video in laboratory and education.

  10. Adversarial Error Resilience in Distributed Storage Using MRD Codes and MDS Array Codes

    CERN Document Server

    Silberstein, Natalia; Vishwanath, Sriram

    2012-01-01

    This paper presents a novel coding scheme for distributed storage systems containing nodes with adversarial errors. The key challenge in such systems is the propagation of the erroneous data from a single corrupted node to the rest of the system during node repair process. We present a concatenated coding scheme which is based on two types of codes: maximum rank distance (MRD) code as an outer code and optimal repair maximal distance separable (MDS) array code as an inner code. We prove that this coding scheme attains the upper bound on the resilience capacity, i.e., amount of data stored reliably in a system with a limited number of corrupted nodes.

  11. Extramedullary Acute Myeloid Leukemia (AML: Leukemic Pleural Effusion, Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    NaveenPemmaraju

    2014-06-01

    Full Text Available Objective and Importance: Malignant pleural effusions occur in the setting of both solid and hematologic malignancies. Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML with fewer than 20 cases reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature. Clinical presentation: In this case, a 55 year old man with previous history of myeloproliferative neoplasm (MPN experienced transformation AML, heralded by appearance of leukemic pleural effusions. The patient was identified to have leukemic pleural effusion based upon extended cytogenetic analysis of the pleural fluid, as morphologic analysis alone was insufficient. Intervention: The patient was treated with hypomethylator-based and intensive chemotherapy strategies, both of which maintained resolution of the effusions in the remission setting. Conclusion: Due to the rarity of diagnosis of leukemic pleural effusions, both cytogenetic and fluorescence in situ hybridization (FISH testing are recommended. Futhermore, systemic chemotherapy directed at the AML can lead to complete resolution of leukemic pleural effusions. Objective and ImportancePleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML, but may be more common than previously thought. Fewer than 20 cases have been reported.1-11 We report a case of pericardial and pleural effusions in a patient with AML and review the literature.

  12. Patient-derived acute myeloid leukemia (AML) bone marrow cells display distinct intracellular kinase phosphorylation patterns

    International Nuclear Information System (INIS)

    Multiparametric analyses of phospho-protein activation in patients with acute myeloid leukemia (AML) offers a quantitative measure to monitor the activity of novel intracellular kinase (IK) inhibitors. As recent clinical investigation with FMS-like tyrosine-3 inhibitors demonstrated, targeting IK with selective inhibitors can have a modest clinical benefit. Because multiple IKs are active in patients with AML, multikinase inhibitors may provide the necessary inhibition profile to achieve a more sustained clinical benefit. We here describe a method of assessing the activation of several IKs by flow cytometry. In 40 different samples of patients with AML we observed hyper-activated phospho-proteins at baseline, which is modestly increased by adding stem cell factor to AML cells. Finally, AML cells had a significantly different phospho-protein profile compared with cells of the lymphocyte gate. In conclusion, our method offers a way to determine the activation status of multiple kinases in AML and hence is a reliable assay to evaluate the pharmacodynamic activity of novel multikinase inhibitors

  13. Flugmechanik und Flugregelung von Luftschiffen

    OpenAIRE

    Kämpf, Bernhard G.

    2004-01-01

    In der vorliegenden Arbeit wird eine geschlossene algebraische Modellierung der Flugmechanik von Luftschiffen entwickelt und im Rahmen analytischer und numerischer Untersuchungen angewendet. Die Resultate geben eine allgemeine Einsicht in die flugmechanischen Eigenschaften von Luftschiffen und werden in den Entwurf einer Flugreglerstruktur umgesetzt. Neben der Darstellung der Gewichts- und Schubkräfte werden die aerostatischen und thermodynamischen Zusammenhänge dargestellt. Der Schwerpunk...

  14. c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression

    International Nuclear Information System (INIS)

    AML1-ETO fusion protein, a product of leukemia-related chromosomal translocation t(8;21), was reported to upregulate expression of connexin-43 (Cx43), a member of gap junction-constituted connexin family. However, its mechanism(s) remains unclear. By bioinformatic analysis, here we showed that there are two putative AML1-binding consensus sequences followed by two activated protein (AP)1 sites in the 5'-flanking region upstream to Cx43 gene. AML1-ETO could directly bind to these two AML1-binding sites in electrophoretic mobility shift assay, but luciferase reporter assay revealed that the AML1 binding sites were not indispensable for Cx43 induction by AML1-ETO protein. Conversely, AP1 sites exerted an important role in this event. In agreement, AML1-ETO overexpression in leukemic U937 cells activated c-Jun N-terminal kinase (JNK), while its specific inhibitor SP600125 effectively abrogated AML1-ETO-induced Cx43 expression, indicating that JNK signaling pathway contributes to AML1-ETO induced Cx43 expression. These results would shed new insights for understanding mechanisms of AML1-ETO-associated leukemogenesis

  15. Tissue-specific upregulation of MDS/EVI gene transcripts in the intestine by thyroid hormone during Xenopus metamorphosis.

    Directory of Open Access Journals (Sweden)

    Thomas C Miller

    Full Text Available BACKGROUND: Intestinal remodeling during amphibian metamorphosis resembles the maturation of the adult intestine during mammalian postembryonic development when the adult epithelial self-renewing system is established under the influence of high concentrations of plasma thyroid hormone (T3. This process involves de novo formation and subsequent proliferation and differentiation of the adult stem cells. METHODOLOGY/PRINCIPAL FINDINGS: The T3-dependence of the formation of adult intestinal stem cell during Xenopus laevis metamorphosis offers a unique opportunity to identify genes likely important for adult organ-specific stem cell development. We have cloned and characterized the ectopic viral integration site 1 (EVI and its variant myelodysplastic syndrome 1 (MDS/EVI generated via transcription from the upstream MDS promoter and alternative splicing. EVI and MDS/EVI have been implicated in a number of cancers including breast, leukemia, ovarian, and intestinal cancers. We show that EVI and MDS/EVI transcripts are upregulated by T3 in the epithelium but not the rest of the intestine in Xenopus laevis when adult stem cells are forming in the epithelium. CONCLUSIONS/SIGNIFICANCE: Our results suggest that EVI and MDS/EVI are likely involved in the development and/or proliferation of newly forming adult intestinal epithelial cells.

  16. Schwangerschaftshypertonie: Therapie und Nachsorge

    Directory of Open Access Journals (Sweden)

    Homuth V

    2008-01-01

    Full Text Available Kurzfassung: Hypertensive Schwangerschaftserkrankungen komplizieren mehr als 10 % aller Schwangerschaften weltweit. Klinisch am bedeutsamsten sind die durch Hypertonie und Proteinurie nach der 20. Schwangerschaftswoche definierte schwangerschaftsinduzierte Präeklampsie und Pfropfpräeklampsie, insbesondere deren schwerste Verlaufsformen Eklampsie und HELLP-Syndrom. Sie gehören global unverändert zu den führenden Ursachen für fetale, neonatale und mütterliche Morbidität und Mortalität. Ihre Ätiologie ist unbekannt und daher ist mit Ausnahme der Beendigung der Schwangerschaft eine kausale Therapie nicht möglich. Insbesondere bleibt eine antihypertensive Therapie hinsichtlich der fetalen Entwicklung problematisch und sollte zur Vermeidung mütterlicher kardiovaskulärer Komplikationen erst bei Blutdruckwerten ≥ 170/110 mmHg begonnen werden, bei vorbestehendem Hochdruck oder Pfropfkonstellation (präexistente Nierenerkrankung, Diabetes mellitus bereits ab Blutdruckwerten von ≥ 160/ 100 mmHg. Zu beachten ist dabei die nur geringe Auswahl in der Schwangerschaft einsetzbarer Antihypertensiva, die sich im Wesentlichen auf Methyldopa, und bereits eingeschränkt auf den Betablocker Metoprolol sowie Dihydralazin und den Kalziumantagonisten Nifedipin begrenzt. Eine der wichtigsten Aufgaben nach der Entbindung ist die Gewährleistung und Förderung des Stillens. Aufgrund ausreichender medikamentöser Alternativen ist ein Abstillen wegen einer antihypertensiven Therapie nicht indiziert. Ergebnisse aktueller Untersuchungen zeigen, dass eine Hypertonie in der Schwangerschaft und ihre Komplikationen Frühgeburtlichkeit und vermindertes Geburtsgewicht einen bedeutsamen Risikofaktor für das Auftreten kardiovaskulärer Erkrankungen, wie Herzinfarkt und Schlaganfall, im späteren Leben darstellen. Daher sind für davon Betroffene frühzeitige Maßnahmen zur kardiovaskulären Prävention und lebenslangen Verlaufskontrolle zu fordern.

  17. Architekturvermittlung an Kinder und Jugendliche

    OpenAIRE

    Nadansky, Martina

    2006-01-01

    In einer Zeit voller wirtschaftlicher und sozialer Brennpunkte mag die Auseinandersetzung mit Architektur nicht nahe liegen, wenn man den Aspekt der ästhetischen Gestaltung in den Vordergrund stellt. Architektur war und ist jedoch immer auch ein Seismograph der Gesellschaft, ihrer politischen, wirtschaftlichen und soziologischen Umstände und in sofern Ausdruck unseres höchsten Kulturgutes – des geistigen, emotionalen und sozial befriedigenden Zusammenlebens. Kinder und Jugendliche sind ein Te...

  18. A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Xiao-Jian; Wang, Zhanxin; Wang, Lan; Jiang, Yanwen; Kost, Nils; Soong, T. David; Chen, Wei-Yi; Tang, Zhanyun; Nakadai, Tomoyoshi; Elemento, Olivier; Fischle, Wolfgang; Melnick, Ari; Patel, Dinshaw J.; Nimer, Stephen D.; Roeder, Robert G.

    2013-06-30

    Transcription factors are frequently altered in leukaemia through chromosomal translocation, mutation or aberrant expression. AML1–ETO, a fusion protein generated by the t(8;21) translocation in acute myeloid leukaemia, is a transcription factor implicated in both gene repression and activation. AML1–ETO oligomerization, mediated by the NHR2 domain, is critical for leukaemogenesis, making it important to identify co-regulatory factors that ‘read’ the NHR2 oligomerization and contribute to leukaemogenesis. Here we show that, in human leukaemic cells, AML1–ETO resides in and functions through a stable AML1–ETO-containing transcription factor complex (AETFC) that contains several haematopoietic transcription (co)factors. These AETFC components stabilize the complex through multivalent interactions, provide multiple DNA-binding domains for diverse target genes, co-localize genome wide, cooperatively regulate gene expression, and contribute to leukaemogenesis. Within the AETFC complex, AML1–ETO oligomerization is required for a specific interaction between the oligomerized NHR2 domain and a novel NHR2-binding (N2B) motif in E proteins. Crystallographic analysis of the NHR2–N2B complex reveals a unique interaction pattern in which an N2B peptide makes direct contact with side chains of two NHR2 domains as a dimer, providing a novel model of how dimeric/oligomeric transcription factors create a new protein-binding interface through dimerization/oligomerization. Intriguingly, disruption of this interaction by point mutations abrogates AML1–ETO-induced haematopoietic stem/progenitor cell self-renewal and leukaemogenesis. These results reveal new mechanisms of action of AML1–ETO, and provide a potential therapeutic target in t(8;21)-positive acute myeloid leukaemia.

  19. Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival

    OpenAIRE

    Dayyani, Farshid; Wang, Jianfeng; Yeh, Jing-Ruey J.; Ahn, Eun-Young; Tobey, Erica; Zhang, Dong-Er; Bernstein, Irwin D.; Peterson, Randall T.; Sweetser, David A.

    2008-01-01

    Deletions on chromosome 9q are seen in a subset of acute myeloid leukemia (AML) cases and are specifically associated with t(8;21) AML. We previously defined the commonly deleted region in del(9q) AML and characterized the genes in this interval. To determine the critical lost gene(s) that might cooperate with the AML1-ETO fusion gene produced by t(8;21), we developed a set of shRNAs directed against each gene in this region. Within this library, shRNAs to TLE1 and TLE4 were the only shRNAs c...

  20. Nitridoborate und Nitridocarbonate der Seltenerdelemente

    OpenAIRE

    Neukirch, Michael

    2007-01-01

    Die vorliegende Arbeit befasst sich mit der Darstellung und Charakterisierung von Verbindungen im System A-B-C-N (A = EA, M oder SE). In diesem System sind Nitridoborate (Anionen aus B und N), Nitridocarbonate (Anionen aus C und N) und Tetracyanoborate (Anionen aus B, C und N) bekannt. Das Gebiet der Nitridoborate wurde im Rahmen dieser Arbeit um die Verbindungen YNi(BN) und SE(1-x)CaxNi(BN) mit SE = Tm (x = 0,3; 0,5 und 0,7) und Yb (x = 0,5) erweitert. Neben der röntgenographischen Chara...

  1. The Corepressor mSin3A Regulates Phosphorylation-Induced Activation, Intranuclear Location, and Stability of AML1

    OpenAIRE

    Imai, Yoichi; Kurokawa, Mineo; Yamaguchi, Yuko; Izutsu, Koji; Nitta, Eriko; Mitani, Kinuko; Satake, Masanobu; Noda, Tetsuo; Ito, Yoshiaki; Hirai, Hisamaru

    2004-01-01

    The AML1 (RUNX1) gene, one of the most frequent targets of translocations associated with human leukemias, encodes a DNA-binding protein that plays pivotal roles in myeloid differentiation through transcriptional regulation of various genes. Previously, we reported that AML1 is phosphorylated on two serine residues with dependence on activation of extracellular signal-regulated kinase, which positively regulates the transcriptional activity of AML1. Here, we demonstrate that the interaction b...

  2. Arbeit und Nicht-Arbeit : Entgrenzungen und Begrenzungen von Lebensbereichen und Praxen

    OpenAIRE

    2009-01-01

    "Mit dem Begriff der Entgrenzung lassen sich aktuelle Phänomene des Wandels von Arbeit und Arbeitskulturen fassen. Lange bestehende Standards von Arbeitsverträgen, Arbeitszeiten oder Arbeitsplätzen und -orten befinden sich in Auflösung oder werden ausgeweitet. Abgrenzungen von Arbeit und Arbeitslosigkeit, Familien- und Reproduktionsarbeit, von klassischer Lohnarbeit und Bürgerarbeit sowie gesellschaftlichem Engagement verlieren zunehmend an Schärfe. Die Grenzen der Bedeutung und des Verständn...

  3. Psychiatrische Erkrankungen und Wirtschaftskrisen

    Directory of Open Access Journals (Sweden)

    Berghofer G

    2014-01-01

    Full Text Available Es besteht ein enger Zusammenhang von wirtschaftlichen Krisen und erhöhten Raten an Arbeitslosigkeit mit psychischen Erkrankungen wie Depressionen, Angstzuständen, Schlafstörungen und Alkoholismus sowie erhöhten Suizidraten. Gleichzeitig gibt es wirkungsvolle Maßnahmen, diesen schädlichen Gesundheitsauswirkungen von Wirtschaftskrisen effektiv entgegenzuwirken. Dazu gehören soziale und finanzielle Absicherungsprogramme, arbeitsmarktpolitische Förderangebote, Unterstützungsmaßnahmen für Familien und Entschuldungsprogramme. In Wirtschaftskrisen vorgenommene Kürzungen im Gesundheitswesen führen hingegen zu einer Verschlechterung der gesundheitlichen Versorgung und längerfristig zu erhöhten Gesundheitskosten. Um negativen gesundheitlichen Auswirkungen von Wirtschaftskrisen effektiv vorzubeugen, sollte daher präventiv in den Ausbau psychosozialer Angebote und medizinischer wie therapeutischer Versorgungseinrichtungen mit niederschwelligem Zugang investiert werden.

  4. Morbus Crohn und Psychosomatik

    Directory of Open Access Journals (Sweden)

    Moser G

    2011-01-01

    Full Text Available Die psychosoziale Dimension bei Morbus Crohn soll in der Diagnostik und Therapie dieser chronisch entzündlichen Darmerkrankung berücksichtigt werden. Dieses Leiden trifft zumeist junge Individuen, nimmt einen chronischen Verlauf, ist mit tabuisierten Beschwerden verbunden und derzeit trotz intensiver Forschung unheilbar. Beeinträchtigte Lebensqualität und psychische Störungen wie Angst und Depressivität sind mögliche Folgen dieser Erkrankung. Die moderne psychosomatische Medizin bezieht sich auf das biopsychosoziale Modell, in dem parallel die biologischen, psychischen und sozialen Faktoren bei der Entstehung und dem Verlauf von Erkrankungen zu berücksichtigen sind. In der folgenden Übersichtsarbeit werden diese Faktoren für den Morbus Crohn dargestellt.

  5. Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

    DEFF Research Database (Denmark)

    Rishi, Loveena; Hannon, Maura; Salomè, Mara;

    2014-01-01

    α (C/EBPα)-p42, occurs in acute myeloid leukemia (AML), resulting in the perturbation of cell cycle and apoptosis, emphasizing its importance in the molecular pathogenesis of AML. Here we show that E2F family members directly regulate Trib2 in leukemic cells and identify a feedback regulatory loop...... cycle or Trib2 knockdown resulted in a block in AML cell proliferation. Our work proposes a novel paradigm whereby E2F1 plays a key role in the regulation of Trib2 expression important for AML cell proliferation control. Importantly, we identify the contribution of dysregulated C/EBPα and E2F1 to...

  6. Ethnografische Diskursanalyse und Sozialwissenschaften

    OpenAIRE

    Macgilchrist, Felicitas; Hout, Tom Van

    2011-01-01

    Ethnografie und Diskursanalyse werden in den Sozialwissenschaften zunehmend kombiniert. In diesem Beitrag wird zunächst ein Überblick gegeben über das entstehende Feld der mit den Epistemologien und Methoden der Ethnografie und Diskursanalyse arbeitenden Forschung. Im zweiten Schritt werden zentral Aspekte eines neuen, computergestützten Ansatzes zur ethnografischen Diskursanalyse vorgestellt. Dieser mikroanalytische Ansatz bietet die Möglichkeit, Erkenntnisse über das Ringen um Deutungsmuste...

  7. Nachhaltige Bodenbewirtschaftung und Bodenschutz

    OpenAIRE

    Ehrnsberger, Rainer

    2010-01-01

    Es werden aus bodenbiologischer Sicht die Funktion, Bedeutung und Gefährdung unserer Böden dargestellt und die Ziele einer nachhaltigen Bodenbewirtschaftung angesichts der allgemeinen Diskussion um "Sustainable Development" erläutert. Die Neuerungen des Bundes-Bodenschutzgesetzes von 1998 werden diskutiert und anhand der Ergebnisse einer Machbarkeitsstudie zum Thema "Erlebnisbereich Boden" dargelegt, wie die Ziele einer nachhaltigen Bodenbewirtschaftung gerade in einer neuen Dauerausstellung ...

  8. Information und Macht : Proceedings

    OpenAIRE

    1993-01-01

    Die 12 Beiträge des vorliegenden Sammelbands versuchen quer zu bestehenden Disziplinen und Diskursen dem Zusammenhang von Information und Macht nachzugehen. Informationsforschung ist ein Forschungsfeld, das unterschiedliche disziplinäre Zugangsweisen - sie reichen von der Soziologie über Wirtschaftsinformatik bis zur Kunst - zu verbinden vermag. Die Autoren wollen die Fruchtbarkeit dieses inter- und intradisziplinären Unternehmens an den folgenden Themenkomplexen demonstrieren: (1) 'Informati...

  9. RFID: Grundlagen und Potenziale

    OpenAIRE

    Overmeyer, Ludger; Vogeler, Stefan

    2005-01-01

    Die Radio Frequenz Identifikation (RFID) erlaubt es, Objekte mit Transpondern zu versehen und sie dadurch eindeutig zu identifizieren sowie drahtlos Daten auszutauschen. Das Potenzial der RFID erstreckt sich dabei weit über die einfache Identifikation von Objekten und bietet die Möglichkeit, Daten lokal zu speichern, sensorisch zu erfassen und am Objekt zu verarbeiten bzw. Steuerungs-entscheidungen zu treffen. Für die volle Ausschöpfung dieses Potenzials sind technologische Fragestellungen de...

  10. Resilienz - Konstrukt und Facetten

    OpenAIRE

    Casper, Miriam

    2014-01-01

    Mit dieser Arbeit soll ein Beitrag zur Weiterentwicklung der Diskussion zum Thema Resilienz geleistet werden. Zielstellung ist es, zu einer Elaboration des Konstrukts und seiner Faktoren und Facetten beizutragen. Resilienz wird dabei als Persönlichkeitsmerkmal verstanden, das den Menschen befähigt, schwierige Lebenssituationen ohne anhaltende Beeinträchtigung zu überstehen (Duden, 2014). Die teststatistische Untersuchung der englischsprachigen RS-25 (Wagnild/Young, 1993) und der deutschsprach...

  11. Schwerpunktbericht: Migration und Gesundheit

    OpenAIRE

    Razum, Oliver; Meesmann, Uta; Bredehorst, Maren; Brzoska, Patrick; Dercks, Tanja; Glodny, Susanne; Zeeb, Hajo; Schenk, Liane; Salman, Ramazan; Menkhaus, Björn; Ulrich, Ralf; Saß, Anke-Christine

    2008-01-01

    Fast ein Fünftel der Menschen in Deutschland hat einen Migrationshintergrund. Sie sind entweder selbst zugewandert oder Kinder und Enkel von Zuwanderern. Ein Migrationshintergrund bringt Chancen und Risiken mit sich, sowohl für die Lebenssituation als auch für die Gesundheit. Hinweis: Auf der RKI-Homepage können Sie Daten zum Schwerpunktbericht "Migration und Gesundheit" (ergänzende Wertetabellen zu den Abbildungen) herunterladen.

  12. Fotografie und atomare Katastrophe

    OpenAIRE

    Bürkner, Daniel

    2015-01-01

    Die Dissertation setzt sich mit den fotografischen Repräsentationen der Atombombenabwürfe auf Hiroshima und Nagasaki sowie der Havarie des Kernkraftwerks Tschernobyl auseinander. Dabei werden künstlerische, dokumentarische und touristische Bilder analysiert, die sich der jeweiligen Strahlenkatastrophe oftmals erst Jahre nach dem Ereignis annehmen und ikonografische oder medial-materielle Bezüge zu ihr aufweisen. Es zeigen sich zentrale Strategien, atomare Katastrophen, seien sie militäri...

  13. Nachhaltigkeit und Menschenbilder

    OpenAIRE

    Siebenhüner, Bernd

    2001-01-01

    "Die praktische Umsetzung der Nachhaltigkeit in Politik und Gesellschaft erfordert eine Reflexion der den unterschiedlichen Maßnahmen zugrunde liegendenden Menschenbilder, die jedoch stets sowohl normativ als auch deskriptiv-analytisch sind. Im Artikel werden Menschenbildentwürfe wie der homo oeconomicus, der homo sociologicus, der homo politicus, der homo oecologicus und der homo sustinens unter dem Blickwinkel ihrer Erklärungs- und Gestaltungsbeiträge erörtert." (Autorenreferat)

  14. Arbeitsbedingungen, Gesundheit und Arbeitsleistung

    OpenAIRE

    Binnewies, Carmen; Sonnentag, Sabine

    2006-01-01

    Stress ist ein weit verbreitetes und zunehmendes Phänomen in der Arbeitswelt. Dass stressvolle Arbeitsbedingungen mit einer negativen Beeinträchtigung der Gesundheit einhergehen, wurde vielfach und relativ eindeutig durch die Forschung bestätigt. Für Arbeitsleistung zeigen sich in der Tendenz ebenfalls eher negative Zusammenhänge mit stressvollen Arbeitsbedingungen. Allerdings scheint es unter bestimmten Bedingungen auch keine oder auch positive Zusammenhänge zu geben und die Ergebnisse müsse...

  15. Kronos und der walfisch

    Directory of Open Access Journals (Sweden)

    Janez Stanovnik

    2016-02-01

    Full Text Available Nach Hesiod, Theog. 154—210 entmannte Kronos seinen Vater Uranos, als sich dieser Gaia in der Nacht nahte, indem er ihm mit der von seiner Mutter gegebenen Sichel sein Glied abschnitt. Es ist bekannt, daß das Verhältnis zwischen Uranos und Kronos eine Dublette des Verhältnisses zwischen Kronos und seinen Kindern, insbesondere Zeus, ist. Laut der Theogonie hat auch Zeus dasselbe seinem Vater Kronos angetan: er hat ihn mit Honig trunken gemacht und ihn damn im Schlaf gefesselt und entmannt.

  16. Sternbilder und ihre Mythen

    Science.gov (United States)

    Fasching, Gerhard

    Die Sternbilder, die seit alters her die Menschen in ihren Bann gezogen haben, und die damit verbundenen Mythen werden in zweifacher Weise vorgestellt. Erstens ist es die Absicht, dem Leser zu helfen, sich am Sternenhimmel zurechtzufinden, und zweitens will es ihm die Vielfalt der Bilder vermitteln, die damit verbunden sind. Am Anfang des Buches stehen die prächtigen Erzählungen aus Ovids Metamorphosen. Dann ist vom Sternenhimmel im Jahreskreis die Rede, um den Leser anzuregen, diesen fast unendlichen Bilderreichtum sich selbst durch eigene Beobachtungen zu erschließen. Ein umfangreicher Abschnitt behandelt die einzelnen Sternbilder und das hierzu überlieferte Wissen. Sternkarten und alte Kupferstiche aus dem Bestand der Österreichischen Nationalbibliothek zeigen, wie man sich in früheren Jahrhunderten den Sternenhimmel vorgestellt hat. Sternsagen und Mythen werden erzählt und auch das ptolemäische und das kopernikanische Weltsystem werden einander gegenübergestellt. Ausführliche Sachverzeichnisse mit über 3000 Suchbegriffen erleichtern den Zugang zu Stern- und Sternbildnamen und zur Mythologie.

  17. Lipidsenker, Statine und Fibrate

    Directory of Open Access Journals (Sweden)

    Hoppichler F

    1999-01-01

    Full Text Available Eine Behandlung der Hyperlipidämie durch Diät und medikamentöse Lipidsenkung führt bekanntermaßen zu einer signifikanten Verringerung kardiovaskulärer Ereignisse. Neben dem lipidsenkenden Effekt führen Statine zur Stabilisierung atherosklerotischer Plaques und Fibrate bewirken eine deutliche Verringerung des Risikofaktors Fibrinogen. Der Effekt einer Kombination von Statinen und Fibraten wird in laufenden Studien, wie der FENICE und UKLDS untersucht, wobei letztere den Einfluß dieser Therapieformen auf das Gefäßrisiko beim diabetischen Patienten zum Inhalt hat.

  18. Digital Natives und Datenschutz

    Directory of Open Access Journals (Sweden)

    Triz Heider

    2010-04-01

    Full Text Available Dieser Artikel lädt dazu ein, sich ein Bild der virtuellen Welt zu machen, ihre eingeborenen User zu verstehen, ihre Sprache und Kultur kennen zu lernen und damit einen Schritt zur Integration in „die digitale Gesellschaft“ (falls es sie gibt zu tun. Es findet eine Auseinandersetzung über die aktuelle Entwicklung des Internets, notwendige Kompetenzen Hilfesuchender und die Architektur von virtueller Beratung statt. Aspekte von Datenschutz und Privatsphäre runden die Ausführungen ab. Dabei werden sowohl aktuelle Themen angesprochen, als auch Vergleiche mit anderen, großen Internetangeboten wie SocialNetworks herangezogen.

  19. T-cell receptor Vbeta CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia

    DEFF Research Database (Denmark)

    Vries, A.C. de; Langerak, A.W.; Verhaaf, B.;

    2008-01-01

    (Very) severe acquired aplastic anemia ((v)SAA) and myelodysplastic syndrome (MDS) are rare diseases in childhood. (V)SAA is a bone marrow (BM) failure syndrome characterized by immune-mediated destruction of hematopoietic progenitors. MDS is a malignant clonal stem cell disorder, of which...

  20. Darstellung und Untersuchung von niederkoordinierten Platinimino-, Platinoxo- und Platinalkylidenborylkomplexen

    OpenAIRE

    Brand, Johannes

    2015-01-01

    Diese Dissertation handelt von der Darstellung, Charakterisierung und Reaktivitätsuntersuchungen von neuartigen Platinalkylidenborylkomplexen und eines heteroleptischen Platiniminoborylkomplexes. Außerdem wurden Reaktivitätsuntersuchungen an einem Platinoxoborylkomplex durchgeführt und die erhaltenen Produkte wurden genau untersucht und charakterisiert.

  1. Improved MDS-based Sensor Localization Algorithm in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Yiqing Zhang

    2013-09-01

    Full Text Available Sensor localization technology is the principle problem for configuration and operation of wireless sensor network. Since existing multidimensional scaling localization algorithm has its limitation in localization accuracy, a novel method based on node distance correction (DCMDS is put forward. The improved multidimensional scaling-based sensor localization algorithm partly divides the location areas of the whole network. It achieves the relative position by distance information among the nodes. Then the distance estimations are corrected according to the distance information of anchor nodes. When the corrected estimations distance matrix is completed, relative position is recalculated with classical MDS algorithm. The optimized particle swarm optimization is used to acquire the final localization results. The performances of DCMDS algorithm were validated in different scenario. The experiments revealed that improved method has high accuracy in localization and low complexity for calculation and communication. It also enhances the extensibility of localization algorithms

  2. [Iron chelation therapy and its influence on the alleviation of EPO resistance in MDS patients].

    Science.gov (United States)

    Zhang, Yao; Xiao, Chao; Gu, Shu-Cheng; Chang, Chun-Kang

    2014-08-01

    This study was aimed to investigate the changes of erythropoietin (EPO), hemoglobin(Hb) and recombinant EPO (rEPO) levels in MDS patients receiving iron chelation therapy, and to explore the relationship between EPO and serum ferritin(SF). A total of 172 MDS patients and 30 healthy controls were studied. The levels of SF, EPO, serum iron (SI), total iron binding capacity (TIBC), C-reaction protein (CRP) and Hb were measured respectively, the level of SF was adjusted according to the changes of CRP. Among them, there were 34 cases of low-risk (SF>1 000 mg/L) receiving deferoxamine therapy, whose changes of SF, EPO, SI, TIBC, Hb levels were detected and compared before and after treatment. Besides, the difference in the incidence of EPO resistance in iron overload group and non-iron overload group was assessed before and after therapy, and 58 cases of low-risk and EPO<1 000 U/L MDS patients were given rEPO therapy. The results showed that the level of EPO in non-iron overload group was higher than that in the normal control group (997.44 ± 473.48 vs 467.27 ± 238.49, P < 0.05). Obviously, the level of EPO in iron overload group was higher than that in non-iron overload group and control group (3257.59 ± 697.19 vs 997.44 ± 473.48, P = 0.012, 3257.59 ± 697.19 vs 467.27 ± 238.49, P = 0.002). Otherwise, the incidence of EPO resistance in iron overload group was higher than that in non-iron overload group (18/35 vs 2/23, P = 0.001), and the level of EPO and SF was positively related to each other in iron overload group (r = 0.310,P = 0.036). After receiving iron chelation therapy, the levels of SF, SI, TIBC and EPO in iron overload group were significantly lower than that before therapy (3942.38 ± 641.82 vs 2266.35 ± 367.31, P = 0.028;48.61 ± 10.65 vs 28.52 ± 12.61, P = 0.034;59.84 ± 12.62 vs 33.76 ± 15.43, P = 0.045;3808.01 ± 750.22 vs 1954.78 ± 473.18, P = 0.042). Moreover, the level of Hb increased (35 ± 18 vs 57 ± 21, P = 0.046) and the EPO resistance

  3. Analysis of local ionospheric variability based on SVD and MDS at low-latitude GNSS stations

    Science.gov (United States)

    Dabbakuti, J. R. K. Kumar; Devanaboyina, Venkata Ratnam; Kanchumarthi, S. Ramesh

    2016-06-01

    Investigation of ionospheric anomalies during equatorial and low latitude is of major concern for modeling and global navigation satellite system (GNSS) applications. Total electron content (TEC) varies with the ionospheric conditions, which will lead to the errors in the global positioning system (GPS) measurements. It is therefore a method that is necessary to characterize the ionospheric anomalies for satellite-based navigation systems. In this study, characterization of ionospheric variations based on the singular value decomposition (SVD) and classical multidimensional scaling (MDS) methods was studied. The yearly and daily variations are decomposed from the GPS-TEC, international reference ionosphere (IRI) 2007 and IRI 2012 models TEC over the three low-latitude GNSS stations located at Koneru Lakshmaiah University (KLU-Guntur), Hyderabad and Bangalore, respectively. From the results, it is found that there is a strong correlation between GPS-TEC and IRI models. The correlation coefficient for the first three singular values is more than 0.86. From this, it is possible to reconstruct more than 85 % of the variability contained in global GPS-derived VTEC data (for year 2013) by using only the first three modes. The semiannual variation has maximum value during March-April and September-October and has minimum value during June-July. It is observed that the annual variations have maximum value in summer and minimum value in winter, and the amplitudes decrease with increasing latitude. Further, opposite latitudinal asymmetry among annual and semiannual variations for three GNSS stations is noticed. SVD and MDS methods clearly show time-varying characteristics and the absence of the winter anomaly at low-latitude GNSS stations.

  4. Isotopes and innovation: MDS Nordion's first fifty years, 1946-1996

    International Nuclear Information System (INIS)

    Few people realize that Canada leads in the world in the production of radio isotopes, the raw material of nuclear medicine and high-tech scanners, and in their use in medicine and industry. In Isotopes and Innovation the author gives an in-depth look at MDS Nordion, a company that started as the radium sales department of Eldorado Mining and Refining, the Canadian uranium producer that was a key strategic resource for the Allies during the race to build the nuclear bomb, and went on to become the world?s leading producer of radioisotopes. When radium began to be used as a cancer treatment, Eldorado quickly became familiar with the medical marketplace and adept at developing products that could solve clinical problems and, more important, save lives. When Canadian nuclear reactors at Chalk River began producing radioisotopes that outperformed radium, Eldorado's radium sales department was transferred to a new crown corporation, Atomic Energy of Canada Limited, created to manage Canada's nuclear research establishment. The new company developed many useful applications for radioisotopes, including cobalt-60 cancer therapy machines and industrial sterilization plants. Bought by Medical Data Services Inc. in the early 1990s, MDS Nordion was a runaway success, creator and sole proprietor of several market-leading products. Isotopes and Innovation describes how a company capitalized on the byproducts of Canada's unique nuclear research program to attain a commanding international position in extremely specialized and demanding high-tech markets, a saga in which innovative research and enterprising global marketing have brought commercial success and saved countless lives around the world

  5. Epilepsie und psychiatrische Erkrankungen

    Directory of Open Access Journals (Sweden)

    Baumgartner C

    2008-01-01

    Full Text Available Psychiatrische Erkrankungen treten bei Epilepsiepatienten signifikant häufiger auf als in der Allgemeinbevölkerung und als bei Patienten mit anderen chronischen Erkrankungen. Die Depression stellt die häufigste psychiatrische Begleiterkrankung bei Epilepsie dar. Die Häufigkeit von Depressionen korreliert mit der Anfallskontrolle: Sie liegt zwischen 3 und 9 % bei gut kontrollierter Epilepsie, jedoch zwischen 20 und 55 % bei Patienten mit therapieresistenten Epilepsien. Umgekehrt ist bei Patienten mit neu diagnostizierten Epilepsien anamnestisch signifikant häufiger eine Depression zu erheben als in einem Vergleichskollektiv. Diese bidirektionale Beziehung zwischen Epilepsie und Depression könnte durch gemeinsame Pathomechanismen beider Erkrankungen erklärt werden. Obwohl das Vorliegen und der Schweregrad einer Depression die wichtigsten Prädiktoren für die Lebensqualität bei Epilepsiepatienten darstellen, werden Depressionen bei Epilepsiepatienten unterdiagnostiziert und unterbehandelt. Eine psychopharmakologische Behandlung sollte bei Vorliegen einer Begleitdepression deshalb unverzüglich initiiert werden, das epileptogene Potential von Antidepressiva stellt dabei ein vernachlässigbares Risiko dar. Die Prävalenz psychotischer Störungen bei Epilepsiepatienten liegt zwischen 2 und 8 %, wobei sogenannte episodische Psychosen (iktale, postiktale und Alternativpsychosen, die in einem zeitlichen Bezug zum Anfallsgeschehen stehen, und chronische Psychosen (interiktale Psychosen ohne zeitlichen Bezug zu den Anfällen, unterschieden werden können. Die Prävalenz von Angststörungen bei Epilepsiepatienten liegt zwischen 15 und 25 %. Man kann zwischen präiktaler, iktaler, postiktaler und interiktaler Angst unterscheiden.

  6. Investigation of porosity and fractal properties of the sintered metal and semiconductor layers in the MDS capacitor structure

    OpenAIRE

    Skatkov Leonid; Gomozov Valeriy; Bayrachniy Boris

    2012-01-01

    MDS capacitor (metal - dielectric - semiconductor) is a structure in which metal plate is represented by compact bulk-porous pellets of niobium sintered powder, and semiconductor plate - by pyrolytic layer of MnO2. In the present paper we report the results of investigation of microporosity of sintered Nb and pyrolytic MnO2 and also the fractal properties of semiconductor layer.

  7. AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB.

    Science.gov (United States)

    Hornick, Noah I; Doron, Ben; Abdelhamed, Sherif; Huan, Jianya; Harrington, Christina A; Shen, Rongkun; Cambronne, Xiaolu A; Chakkaramakkil Verghese, Santhosh; Kurre, Peter

    2016-01-01

    Exosomes are paracrine regulators of the tumor microenvironment and contain complex cargo. We previously reported that exosomes released from acute myeloid leukemia (AML) cells can suppress residual hematopoietic stem and progenitor cell (HSPC) function indirectly through stromal reprogramming of niche retention factors. We found that the systemic loss of hematopoietic function is also in part a consequence of AML exosome-directed microRNA (miRNA) trafficking to HSPCs. Exosomes isolated from cultured AML or the plasma from mice bearing AML xenografts exhibited enrichment of miR-150 and miR-155. HSPCs cocultured with either of these exosomes exhibited impaired clonogenicity, through the miR-150- and miR-155-mediated suppression of the translation of transcripts encoding c-MYB, a transcription factor involved in HSPC differentiation and proliferation. To discover additional miRNA targets, we captured miR-155 and its target transcripts by coimmunoprecipitation with an attenuated RNA-induced silencing complex (RISC)-trap, followed by high-throughput sequencing. This approach identified known and previously unknown miR-155 target transcripts. Integration of the miR-155 targets with information from the protein interaction database STRING revealed proteins indirectly affected by AML exosome-derived miRNA. Our findings indicate a direct effect of AML exosomes on HSPCs that, through a stroma-independent mechanism, compromises hematopoiesis. Furthermore, combining miRNA target data with protein-protein interaction data may be a broadly applicable strategy to define the effects of exosome-mediated trafficking of regulatory molecules within the tumor microenvironment. PMID:27601730

  8. Milch, Milchprodukte, Analoge und Speiseeis

    Science.gov (United States)

    Coors, Ursula

    Die Produktpalette Milch und Erzeugnisse aus Milch beinhaltet Konsummilch, die aus Milch oder Bestandteilen der Milch hergestellten Milcherzeugnisse wie Sauermilch-, Joghurt-, Kefir-, Buttermilch-, Sahne-, Kondensmilch-, Trockenmilch- und Molkenerzeugnisse, Milchmisch- und Molkenmischprodukte (Produkte mit beigegebenen Lebensmitteln), Milchzucker, Milcheiweißerzeugnisse, Milchfette und Käse.

  9. Chemie metastabiler Anionen : Synthese und Charakterisierung neuer Auride und Ozonide

    OpenAIRE

    Nuß, Hannelore

    2007-01-01

    Die vorliegende Arbeit beschreibt die Synthese und Charakterisierung neuer Ozonid- und Auridverbindungen, sowie Verbindungen des Quadratatdianions. Fünf neue Ozonidverbindungen wurden ausgehend von den Alkalimetallozoniden KO_3, RbO_3 und CsO_3 durch Umsetzung mit verschiedenen Kronenetherliganden in flüssigem Ammoniak hergestellt. Das Verhältnis zwischen Ligandendurchmesser und Kationenradius bestimmt dabei die Art der Komplexierung des Metallzentrums und damit auch die Packung der Kompl...

  10. An Implementation and Evaluation of the AMLS Method for SparseEigenvalue Problems

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Weiguo; Li, Xiaoye S.; Yang, Chao; Bai, Zhaojun

    2006-02-14

    We describe an efficient implementation and present aperformance study of an algebraic multilevel sub-structuring (AMLS)method for sparse eigenvalue problems. We assess the time and memoryrequirements associated with the key steps of the algorithm, and compareitwith the shift-and-invert Lanczos algorithm in computational cost. Oureigenvalue problems come from two very different application areas: theaccelerator cavity design and the normal mode vibrational analysis of thepolyethylene particles. We show that the AMLS method, when implementedcarefully, is very competitive with the traditional method in broadapplication areas, especially when large numbers of eigenvalues aresought.

  11. Markttransformation und politische Instrumente

    Science.gov (United States)

    Irrek, Wolfgang; Thomas, Stefan

    Was die Energieabnehmerinnen und -abnehmer in privaten Haushalten, öffentlichen Einrichtungen und Unternehmen im Grunde benötigen, ist nicht Energie, sondern die Befriedigung ihrer energierelevanten Bedürfnisse (z. B. eine warme Wohnung, kühles Bier, Informationsübertragung oder Kraftanwendung).

  12. Rundfunk und Fernsehen

    OpenAIRE

    2001-01-01

    Rundfunk meint die rein akustische Verbreitung von Musik- und Wortsendungen (sog. Hörfunk) mittels elektromagnetischer Wellen sowie die Organisationseinrichtungen für Sendung und Empfang (Radio-Verkehrs-Aktien-Gesellschaft [RAVAG], Radio Wien, Reichsrundfunk, Rundfunk, Österreichischer [ORF]), Fernsehen das optisch-akustische Analogon dazu.

  13. Manuelle und elektronische Vorgangssteuerung

    OpenAIRE

    Schwickert, Axel C.; Rey, Louis-Ferdinand

    1996-01-01

    Sequentielle Vorgangsbearbeitung und manuelle Vorgangssteuerung sind typische Kennzeichen verrichtungsorientierter Organisationen. Hier werden einzelne Vorgänge und Vorgangsschritte mit Unterstützung allenfalls traditioneller EDV-Systeme von spezialisierten Sachbearbeitern arbeitsteilig abgearbeitet. Auf der Kritik der tradierten manuellen Vorgangssteuerung aufbauend, wird die elektronische Vorgangssteuerung in einer prozeßorientierten Organisation dargestellt. Die prozeßorientierte Vorgangss...

  14. Von Menschenbildern und Hirnmodellen

    OpenAIRE

    Koukkou, M

    2008-01-01

    Haben die beeindruckenden Erkenntnisse der Hirnforschung das Menschenbild verändert, auf das sich die Psychiatrie beruft? Ist die Befürchtung berechtigt, dass dadurch der Beziehungsaspekt und das Biographische in Psychiatrie und Psychotherapie an Bedeutung verlieren? Diesen Fragen geht Martha Koukkou im folgenden Text nach.

  15. Steuern und Governance

    Directory of Open Access Journals (Sweden)

    Eduard Müller

    2014-05-01

    Full Text Available ENGLISH: Taxation, in the modern state, has long been a mass phenomenon with an interdisciplinary outlook. On the macro level of the state, a new generation of administrative reforms has crystallized under the label “good public governance”. These reforms seek to resolve regulatory interdependence of state and non - state actors by way of cooperation and interaction. In parallel, on the micro level of businesses, “corporate governance” – voluntary compliance with legal and ethical standards – has become an increasingly important issue. With a view to tax law and tax collection, these developments open up new possibilities to raise tax compliance by means of consensual and cooperative instruments and, accordingly, address taxation as a mass phenomenon. DEUTSCH: Besteuerung ist im modernen Staat ein Massenphänomen und längst interdisziplinär ausgerichtet. Auf der Makro-Ebene des Staates hat sich unter dem Begriff Good Public Governance eine neue Generation von Staats- und Verwaltungsreformen herausgebildet, die Regelungsbeziehungen von staatlichen und nichtstaatlichen Akteuren durch Kooperationen und Interaktionen zu lösen versucht. Parallel dazu hat auf der Mikro-Ebene der Unternehmen mit dem Thema Corporate Governance die freiwillige Einhaltung von rechtlichen und ethischen Regeln an Bedeutung gewonnen. Für das Steuerrecht und den Steuervollzug resultieren aus diesen Entwicklungen neue Möglichkeiten, durch Nutzung konsens- und kooperationsorientierter Instrumente die Tax Compliance zu erhöhen und so dem Massenphänomen Besteuerung gerecht zu werden.

  16. The MDS Mortality Risk Index: The evolution of a method for predicting 6-month mortality in nursing home residents

    Directory of Open Access Journals (Sweden)

    Parker-Oliver Debra

    2010-07-01

    Full Text Available Abstract Background Accurate prognosis is vital to the initiation of advance care planning particularly in a vulnerable, at risk population such as care home residents. The aim of this paper is to report on the revision and simplification of the MDS Mortality Rating Index (MMRI for use in clinical practice to predict the probability of death in six months for care home residents. Methods The design was a secondary analysis of a US Minimum Data Set (MDS for long term care residents using regression analysis to identify predictors of mortality within six months. Results Using twelve easy to collect items, the probability of mortality within six months was accurately predicted within the MDS database. The items are: admission to the care home within three months; lost weight unintentionally in past three months; renal failure; chronic heart failure; poor appetite; male; dehydrated; short of breath; active cancer diagnosis; age; deteriorated cognitive skills in past three months; activities of daily living score. Conclusion A lack of recognition of the proximity of death is often blamed for inappropriate admission to hospital at the end of an older person's life. An accurate prognosis for older adults living in a residential or nursing home can facilitate end of life decision making and planning for preferred place of care at the end of life. The original MMRI was derived and validated from a large database of long term care residents in the USA. However, this simplification of the revised index (MMRI-R may provide a means for facilitating prognostication and end of life discussions for application outside the USA where the MDS is not in use. Prospective testing is needed to further test the accuracy of the MMRI-R and its application in the UK and other non-MDS settings.

  17. ELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.

    Science.gov (United States)

    Capala, Marta E; Vellenga, Edo; Schuringa, Jan Jacob

    2014-01-01

    Both normal as well leukemic hematopoietic stem cells critically depend on their microenvironment in the bone marrow for processes such as self-renewal, survival and differentiation, although the exact pathways that are involved remain poorly understood. We performed transcriptome analysis on primitive CD34+ acute myeloid leukemia (AML) cells (n = 46), their more differentiated CD34- leukemic progeny, and normal CD34+ bone marrow cells (n = 31) and focused on differentially expressed genes involved in adhesion and migration. Thus, Engulfment and Motility protein 1 (ELMO1) was identified amongst the top 50 most differentially expressed genes. ELMO1 is a crucial link in the signaling cascade that leads to activation of RAC GTPases and cytoskeleton rearrangements. We confirmed increased ELMO1 expression at the mRNA and protein level in a panel of AML samples and showed that high ELMO1 expression is an independent negative prognostic factor in normal karyotype (NK) AML in three large independent patient cohorts. Downmodulation of ELMO1 in human CB CD34+ cells did not significantly alter expansion, progenitor frequency or differentiation in stromal co-cultures, but did result in a decreased frequency of stem cells in LTC-IC assays. In BCR-ABL-transduced human CB CD34+ cells depletion of ELMO1 resulted in a mild decrease in proliferation, but replating capacity of progenitors was severely impaired. Downregulation of ELMO1 in a panel of primary CD34+ AML cells also resulted in reduced long-term growth in stromal co-cultures in two out of three cases. Pharmacological inhibition of the ELMO1 downstream target RAC resulted in a severely impaired proliferation and survival of leukemic cells. Finally, ELMO1 depletion caused a marked decrease in SDF1-induced chemotaxis of leukemic cells. Taken together, these data show that inhibiting the ELMO1-RAC axis might be an alternative way to target leukemic cells. PMID:25360637

  18. ELMO1 Is Upregulated in AML CD34+ Stem/Progenitor Cells, Mediates Chemotaxis and Predicts Poor Prognosis in Normal Karyotype AML

    OpenAIRE

    Capala, Marta E.; Vellenga, Edo; Schuringa, Jan Jacob

    2014-01-01

    Both normal as well leukemic hematopoietic stem cells critically depend on their microenvironment in the bone marrow for processes such as self-renewal, survival and differentiation, although the exact pathways that are involved remain poorly understood. We performed transcriptome analysis on primitive CD34+ acute myeloid leukemia (AML) cells (n = 46), their more differentiated CD34− leukemic progeny, and normal CD34+ bone marrow cells (n = 31) and focused on differentially expressed genes in...

  19. Thermodynamik grundlagen und technische anwendungen

    CERN Document Server

    Baehr, Hans Dieter

    2009-01-01

    Für die aktualisierte 14. Auflage des bewährten Lehrbuchs der Technischen Thermodynamik wurde das Kapitel über Wärmekraftanlagen gründlich bearbeitet und durch einen Abschnitt zur Energiewandlung ergänzt: Die Energiebedarfsstruktur von Deutschland wird erläutert, und die möglichen Energiewandlungspfade werden diskutiert. Schwerpunkt des Buches ist die ausführliche und auch dem Anfänger verständliche Darstellung der Grundlagen der Thermodynamik mit der sorgfältigen Einführung der thermodynamischen Begriffe und den fundamentalen Bilanzgleichungen für Energie, Entropie und Exergie. Die thermodynamischen Eigenschaften reiner Fluide und fluider Gemische werden eingehend erläutert. Darauf aufbauend wird die Thermodynamik der Gemische und der chemischen Reaktionen entwickelt. Auch die thermodynamischen Aspekte wichtiger energie- und verfahrenstechnischer Anwendungen werden praxisnah behandelt: - Strömungs- und Arbeitsprozesse, - thermische Stofftrennverfahren, - Verbrennungsprozesse und Verbrennungsk...

  20. Zinkbedarf und Risiko und Nutzen einer Zinksupplementierung

    Directory of Open Access Journals (Sweden)

    Wolfgang Maret

    2014-03-01

    Full Text Available Der Körper eines erwachsenen Menschen enthält 2 – 3 g Zink, von denen pro Tag etwa 0,1% ersetzt werden. Auf dieser Basis und gestützt auf Schätzungen bezüglich der Bioverfügbarkeit von Zink werden Ernährungsempfehlungen für augenscheinlich gesunde Personen gegeben. Das Fehlen chemischer, funktioneller und/oder körperlicher Anzeichen eines Zinkmangels gilt dabei als Hinweis auf eine adäquate Versorgung. Spezifischere Daten sind jedoch nur selten vorhanden. Veränderungen hinsichtlich der Auswahl und Verfügbarkeit von Nahrungsmitteln sowie neue Methoden der Zubereitung, Konservierung und Aufbereitung machen u. U. die Neubewertung älterer Daten erforderlich. Konservative Schätzungen legen nahe, dass bei ≥ 25% der Weltbevölkerung das Risiko für einen Zinkmangel besteht. Die meisten Betroffenen sind arm und konsumieren nur selten Nahrungsmittel, die reich an gut bioverfügbarem Zink sind, sondern eher solche, die einen hohen Gehalt an Inhibitoren der Zinkabsorption aufweisen und/oder kaum bioverfügbares Zink enthalten. Im Gegensatz dazu hat bei vergleichsweise Wohlhabenden die Auswahl der Nahrungsmittel entscheidenden Einfluss auf das Risiko für einen Zinkmangel. Ein weiteres Problem, ebenfalls speziell bei vergleichsweise Wohlhabenden, ist das Risiko einer chronischen Zinkintoxikation durch übermäßige Einnahme von Zinksupplementen. Insbesondere kann eine hohe Aufnahme von Zink verglichen mit Kupfer zu Kupfermangel führen. Eine bedeutende Herausforderung, die im Hinblick auf den maximalen Nutzen für die Gesundheit bisher noch nicht gemeistert worden ist, besteht darin, dass die empfohlene Tagesdosis (recommended dietary allowance, RDA und die Referenzdosis (RfD für eine sichere Aufnahme von Zink sehr nahe beieinander liegen. Aktuelle Empfehlungen berücksichtigen weder die zahlreichen Nahrungsmittelbestandteile, die die Bioverfügbarkeit von Zink und Kupfer beeinflussen, noch die Wahrscheinlichkeit einer Vergiftung durch

  1. Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML

    Science.gov (United States)

    2016-08-03

    Relapsed Acute Lymphoblastic Leukemia (ALL); Refractory Acute Lymphoblastic Leukemia (ALL); Relapsed Acute Myelogenous Leukemia (AML); Refractory Acute Myelogenous Leukemia (AML); Relapsed Mixed Lineage Leukemia; Refractory Mixed Lineage Leukemia; Relapsed Biphenotypic Leukemia; Refractory Biphenotypic Leukemia; Chronic Myelogenous Leukemia (CML) in Blast Crisis

  2. 30 CFR 874.17 - AML agency procedures for reclamation projects receiving less than 50 percent government funding.

    Science.gov (United States)

    2010-07-01

    ... accordance with the provisions of 30 CFR subchapter R; (3) Develop specific-site reclamation requirements... 30 Mineral Resources 3 2010-07-01 2010-07-01 false AML agency procedures for reclamation projects... RECLAMATION REQUIREMENTS § 874.17 AML agency procedures for reclamation projects receiving less than...

  3. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with >30% blasts

    OpenAIRE

    Dombret, Hervé; Seymour, John F.; Butrym, Aleksandra; Wierzbowska, Agnieszka; Selleslag, Dominik; Jang, Jun Ho; Kumar, Rajat; Cavenagh, James; Schuh, Andre C.; Candoni, Anna; Récher, Christian; Sandhu, Irwindeep; Bernal del Castillo, Teresa; Al-Ali, Haifa Kathrin; Martinelli, Giovanni

    2015-01-01

    Azacitidine increased median overall survival by 3.8 months vs current commonly used AML treatments (10.4 vs 6.5 months; P = .1009).Azacitidine safety in patients age ≥65 years with AML (>30% blasts) was consistent with its known safety profile in other trials.

  4. Zusammenfassung Workshop und Umfrageergebnisse "Bedarf und Anforderungen an Ressourcen für Text und Data Mining"

    OpenAIRE

    Sens, Irina; Katerbow, Matthias; Schöch, Christof; Mittermaier, Bernhard

    2015-01-01

    Zusammenfassung des Workshops und Visualisierung der Umfrageerbegnisse der Umfrage "Bedarf und Anforderungen an Ressourcen für Text und Data Mining" der Schwerpunktinitiative "Digitale Information" der Allianz der deutschen Wissenschaftsorganisationen, Arbeitsgruppe Text und Data Mining

  5. MDS-RA、MgA与M6的骨髓细胞形态学鉴别诊断%Differential diagnostic of bone marrow morphocytology in the patients with MDS-RA,MgA and M6

    Institute of Scientific and Technical Information of China (English)

    于远军; 张敏

    2011-01-01

    Objechve: To analyze the bone marrow morphocytology in the patients with MDS-RA. MgA and M6, deepen our understanding of related diseases. Methods: 25 cases diagnosed in our hospital and Shanghai Ruijin Hospital were analyzed. Results: MDS-RA of the bone marrow showed active or significantly active proliferation, occasionally showed by poplasia.The ratio of G/E in bone marrow often reduced and more than two series were dysplastic. MgA of the bone marrow showed significantly active proliferation The ratio of G/E in bone marrow often reduced and the bone marrow cells had a change of giants. M6 of the bone marrow showed significantly active proliferation The ratio of G/E in bone marrow were often inverse. Erythrocytes were significantly dysplastic and the more ratio of blastocytes was found. Conclusion: MDS-RA, MgA and M6 of the bone marrow showed in common that erythrocytes were significantly active proliferation and the bone marrow cells had a change of giants. The differentia shows that the bone marrow of MDS-RA and M6 are dysplastic and have the different ratio of blastocytes. The bone marrow cells of MgA have a change of giants and the ratio of blastocytes is not high.%目的:分析MDS-RA、MgA及M6患者骨髓细胞形态特点,以提高对相关疾病的认识.方法:对在我院及上海瑞金医院确诊的25例MDS-RA,MgA及M6患者的骨髓细胞形态进行分析.结果:MDS-RA骨髓增生活跃或明显活跃,偶见增生减低,粒红比常减低,常见两系以上病态;MgA骨髓增生明显活跃,粒红比常减低,粒红两系出现巨幼样变;M6骨髓增生明显活跃,粒红比常倒置,红系明显病态,原始细胞增多.结论:MDS-RA,MgA及M6的骨髓象共同点:都会出现红系明显增生,出现巨幼样病态改变.不同点:MDS-RA与M6主要是各系病态造血明显,通常以原始细胞比例不同进行鉴别.而MgA主要表现为各系的巨幼样变,且原始细胞比例不高.

  6. Antepartuales fetales Elektrokardiogramm und Kardiotokographie

    OpenAIRE

    Prechtl, Eva Maria

    2006-01-01

    Es wurden 65 Patientinnen zwischen der 17. und 41. Schwangerschaftswoche unter Berücksichtigung der Hauptpathologien "intauterine Wachstumsretardierung" und "Gestationsdiabetes" simultan mit Hilfe der Kineto-Kardiotokographie (KCTG) und des fetalen abdominalen EKGs (AECG) untersucht. Neben dem direkten Vergleich von KCTG- und AECG-Messung wurde die Registrierqualität des AECG hinsichtlich verschiedener Einflussgrößen untersucht und eine Analyse der errechneten Durchschnitts-EKGs vorgenommen. ...

  7. Digitale Lesekompetenz und digitale Kultur

    OpenAIRE

    Jung, Meike

    2016-01-01

    Konzept, Veranstaltungen und Vermittlung in der Stadtbibliothek Stuttgart Unter dem Begriff „digitale Lesekompetenz“ schaut die Stadtbibliothek Stuttgart unter die glänzenden Medienoberflächen. Sie thematisiert die Nutzungsqualitäten und Auswirkungen der digitalen Medien sowie die gesellschaftlichen und persönlichen Konsequenzen. Medien- und Recherchekompetenz, Datenschutz, Privatsphäre und Sicherheit im Netz sind Themen, die von der Stadtbibliothek Stuttgart gemeinsam mit einem Netzwerk v...

  8. Lipide und Diabetes

    Directory of Open Access Journals (Sweden)

    Riedl M

    2002-01-01

    Full Text Available 2010 werden weltweit ca. 220 Millionen Menschen von Diabetes betroffen sein, und die Inzidenz und Prävalenz steigen weiter an. Die meisten dieser Patienten (90 % leiden an Typ-2-Diabetes, der ein 2- bis 4fach höheres Risiko für Herz-Kreislauf-Erkrankungen mit sich bringt. Die pathogenetische Erklärung für das erhöhte atherosklerotische Risiko beim Diabetes ist noch immer kontroversiell. Von allen Risikofaktoren scheint die derzeit am besten modulierbare Größe in bezug auf Atherosklerose und Diabetes die Dyslipidämie zu sein. Sie ist charakterisiert durch ein moderat erhöhtes Gesamt- und Low Density Lipoprotein (LDL-Cholesterin, erhöhte Triglyzeride und ein niedriges High Density Lipoprotein (HDL. Post-hoc-Analysen der Subgruppen der primären Interventionsstudien Helsinki Heart Study und AFCAPS/TexCAPS und der sekundären Interventionsstudien CARE, 4S, LIPID und VA-HIT sowie die DAIS-Studie zeigen eine hohe Wahrscheinlichkeit, daß Lipidreduktion das makrovaskuläre Risiko auch bei Diabetikern senkt. Die erhöhte Inzidenz für Herz-Kreislauf-Erkrankungen bei Diabetes, die größere Sterblichkeitsziffer und die erhöhte 1-Jahres-Mortalität bei Patienten mit Myokardinfarkt deuten stark darauf hin, daß die präventive Senkung der Lipidspiegel bei Diabetikern mit dem Ziel der Erreichung der Werte für die Sekundärprävention erfolgen sollte. Derzeit laufen mehrere randomisierte, doppelblinde, placebokontrollierte Studien mit Statinen an Diabetikern, wie die ASPEN-, die CARDS- und die ALLHAT-Studie, die hoffentlich Antwort auf derzeit offene Fragen geben werden.

  9. c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis

    OpenAIRE

    Nanbakhsh, Arash; Pochon, Cécile; Mallavialle, Aude; Amsellem, Sophie; Bourhis, Jean Henri; Chouaib, Salem

    2014-01-01

    AML cells resistant to cytarabine are more susceptible to NK-mediated cell lysis.c-Myc regulates ULBP1/2/3 expression and interferes with NK cell susceptibility in primary cytarabine resistant AML blasts.

  10. KRAS (G12D Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia

    Directory of Open Access Journals (Sweden)

    Shanmin Zhao

    2014-01-01

    Full Text Available Background/Aims: It has been demonstrated that KRAS mutations represent about 90% of cancer-associated mutations, and that KRAS mutations play an essential role in neoplastic transformation. Cancer-associated RAS mutations occur frequently in acute myeloid leukemia (AML, suggesting a functional role for Ras in leukemogenesis. Methods: We successfully established a mouse model of human leukemia by transplanting bone marrow cells co-transfected with the K-ras (G12D mutation and AML1/ETO fusion protein. Results: Mice transplanted with AML/ETO+KRAS co-transduced cells had the highest mortality rate than mice transplanted with AML/ETO- or KRAS-transduced cells (115d vs. 150d. Upon reaching a terminal disease stage, EGFP-positive cells dominated their spleen, lymph nodes, peripheral blood and central nervous system tissue. Immunophenotyping, cytologic analyses revealed that AML/ETO+KRAS leukemias predominantly contained immature myeloid precursors (EGFP+/c-Kit+/Mac-1-/Gr-1-. Histologic analyses revealed that massive leukemic infiltrations were closely packed in dense sheets that effaced the normal architecture of spleen and thymus in mice transplanted with AML1/ETO + KRAS co-transduced cells. K-ras mRNA and protein expression were upregulated in bone marrow cells of the K-ras group and AML1/ETO + Kras group. The phosphorylation of MEK/ERK was significantly enhanced in the AML1/ETO + Kras group. The similar results of the AML1/ETO + Nras group were consistent with those reported previously. Conclusion: Co-transduction of KrasG12D and AML1/ETO induces acute monoblastic leukemia. Since expression of mutant K-ras alone was insufficient to induce leukemia, this model may be useful for investigating the multi-step leukemogenesis model of human leukemia.

  11. Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.

    OpenAIRE

    Rhoades, K L; Hetherington, C J; Rowley, J D; Hiebert, S W; Nucifora, G; Tenen, D.G.; Zhang, D E

    1996-01-01

    AML1 is involved in the (8;21) translocation, associated with acute myelogenous leukemia (AML)-type M2, which results in the production of the AML1-ETO fusion protein: the amino-terminal 177 amino acids of AML1 and the carboxyl-terminal 575 amino acids of ETO. The mechanism by which AML1-ETO accomplishes leukemic transformation is unknown; however, AML1-ETO interferes with AML1 transactivation of such AML1 targets as the T-cell receptor beta enhancer and the granulocyte-macrophage colony-stim...

  12. Ibrutinib synergizes with poly(ADP-ribose) glycohydrolase inhibitors to induce cell death in AML cells via a BTK-independent mechanism

    OpenAIRE

    Rotin, Lianne E.; Gronda, Marcela; Maclean, Neil; Hurren, Rose; Wang, Xiaoming; Lin, Feng-Hsu; Wrana, Jeff; Datti, Alessandro; Barber, Dwayne L.; Minden, Mark D.; Slassi, Malik; Schimmer, Aaron D.

    2015-01-01

    Targeting Bruton's tyrosine kinase (BTK) with the small molecule BTK inhibitor ibrutinib has significantly improved patient outcomes in several B-cell malignancies, with minimal toxicity. Given the reported expression and constitutive activation of BTK in acute myeloid leukemia (AML) cells, there has been recent interest in investigating the anti-AML activity of ibrutinib. We noted that ibrutinib had limited single-agent toxicity in a panel of AML cell lines and primary AML samples, and there...

  13. Emotionale Entbehrung und narzisstische Regulation - Zur Entstehung und Behandlung depressiver Krisen bei Kindern und Jugendlichen

    OpenAIRE

    du Bois, Reinmar

    2007-01-01

    In diesem Beitrag wird aus kinderpsychiatrischer Perspektive die Genese und Behandlung von Depression im Kindes- und Jugendalter erläutert. Unempathisches Verhalten der Eltern auf Grund eigener psychischer Probleme und die (adaptiven) Reaktionen des Kindes auf Verlust und Trennung werden als Grundmuster der frühen Genese von Depressionen herausgearbeitet. Erbliche Dispositionen ebenso wie unsichere Bindungsmuster und Traumata kommen als begünstigende Faktoren hinzu. Es wird verdeutlicht, dass...

  14. Entwicklung und Anwendung von Mikrohybridisierungsverfahren zur Detektion und Identifizierung von Enterokokken in der Wasser- und Lebensmittelanalytik

    OpenAIRE

    Behr, Thomas Michael

    2007-01-01

    Zur Detektion und Identifizierung von Enterokokken in der Trinkwasser- und Lebensmittelanalytik wurde ein hierarchischer, gegen die rRNS gerichteter Sondensatz nach den Prinzipien des Mehrfachsondenkonzeptes entwickelt. Zur Anwendung dieses Sondensatzes wurden reverse Hybridisierungstechniken in Mikrotiterplatten und auf DNS-Chips evaluiert und optimiert. Damit steht ein Testverfahren zur Verfügung, das eine schnellere und zuverlässigere Identifizierung von Enterokokken bis auf die Artebene e...

  15. Geschichte und Psychologie – Oral History und Psychoanalyse. Problemaufriss und Literaturüberblick

    OpenAIRE

    Plato, Alexander von

    2004-01-01

    Der Aufsatz dreht sich zunächst um die Geschichte des Verhältnisses der beiden Disziplinen Geschichte und Psychologie, um die wichtigsten Felder dieser Beziehungen in den letzten anderthalb Jahrhunderten und um die Bedeutung des subjektiven Elements in der Geschichte und in der Historiographie überhaupt. Vertieft werden solche Grundsatzfragen an den kooperativen Möglichkeiten zwischen Psychoanalyse und Oral History und ihren Problemen, vor allem in den Fragen der Wirkung des Unbewussten in de...

  16. Chrom, Nickel und Zink in Klinker und Zement : Einbau, Eigenschaftsänderung und Auslaugung

    OpenAIRE

    Stephan, Dietmar

    2006-01-01

    Ziel der Arbeit aus dem Gebiet der Bauchemie war die Untersuchung des Einflusses erhöhter Konzentrationen an Spurenelementen (am Beispiel von Cr, Ni und Zn) auf Produktion und Verwendung des Baustoffes Zement. Dazu wurden die reinen Klinkerphasen C3S, C3A und C4AF sowie Betriebsrohmehle mit Schwermetalloxiden in unterschiedlichen Konzentrationen dotiert und gebrannt. An den unhydratisierten Proben wurden Untersuchungen wie z.B. Freikalkbestimmung, Röntgendiffraktometrie (XRD) und Untersuchung...

  17. Adipositas und Herz: Neue Risikofaktoren und Surrogatendpunkte

    Directory of Open Access Journals (Sweden)

    Festa A

    2003-01-01

    Full Text Available Adipositas ist mit einem erhöhten kardiovaskulären Risiko assoziiert. Dieser Zusammenhang ist teilweise unabhängig, zum Teil aber auch über eine erhöhte Prävalenz klassischer und nichtklassischer Risikofaktoren mediiert. Dieser Artikel faßt drei Vorträge zusammen, die anläßlich der dritten Jahrestagung der Österreichischen Adipositasgesellschaft im Rahmen einer Sitzung über neue Risikofaktoren und Surrogatendpunkte gehalten wurden. Dabei werden die Themen Homocystein, C-reaktives Protein, endotheliale Dysfunktion sowie die Intima-Media-Dicke der Karotis näher beleuchtet.

  18. Zinkbedarf und Risiko und Nutzen einer Zinksupplementierung

    OpenAIRE

    Wolfgang Maret; Sandstead, Harold H.

    2014-01-01

    Der Körper eines erwachsenen Menschen enthält 2 – 3 g Zink, von denen pro Tag etwa 0,1% ersetzt werden. Auf dieser Basis und gestützt auf Schätzungen bezüglich der Bioverfügbarkeit von Zink werden Ernährungsempfehlungen für augenscheinlich gesunde Personen gegeben. Das Fehlen chemischer, funktioneller und/oder körperlicher Anzeichen eines Zinkmangels gilt dabei als Hinweis auf eine adäquate Versorgung. Spezifischere Daten sind jedoch nur selten vorhanden. Veränderungen hinsichtlich der Auswah...

  19. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells.

    Directory of Open Access Journals (Sweden)

    Bui Thi Kim Ly

    Full Text Available Acute myeloid leukemia (AML is a heterogeneous disease characterized by a block in differentiation and uncontrolled proliferation. FLT3 is a commonly mutated gene found in AML patients. In clinical trials, the presence of a FLT3-ITD mutation significantly correlates with an increased risk of relapse and dismal overall survival. Therefore, activated FLT3 is a promising molecular target for AML therapies. In this study, we have shown that green tea polyphenols including (--epigallocatechin-3-gallate (EGCG, (--epigallocatechin (EGC, and (--epicatechin-3-gallate (ECG suppress the proliferation of AML cells. Interestingly, EGCG, EGC and ECG showed the inhibition of FLT3 expression in cell lines harboring FLT3 mutations. In the THP-1 cells harboring FLT3 wild-type, EGCG showed the suppression of cell proliferation but did not suppress the expression of FLT3 even at the concentration that suppress 100% cell proliferation. Moreover, EGCG-, EGC-and ECG-treated cells showed the suppression of MAPK, AKT and STAT5 phosphorylation. Altogether, we suggest that green tea polyphenols could serve as reagents for treatment or prevention of leukemia harboring FLT3 mutations.

  20. Genetic and epigenetic similarities and differences between childhood and adult AML

    DEFF Research Database (Denmark)

    Juhl-Christensen, Caroline; Ommen, Hans Beier; Aggerholm, Anni;

    2012-01-01

    The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383...

  1. Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)

    International Nuclear Information System (INIS)

    Chemotherapeutic drug efflux via the P-glycoprotein (P-gp) transporter encoded by the MDR1/ABCB1 gene is a significant cause of drug resistance in numerous malignancies, including acute leukemias, especially in older patients with acute myeloid leukemia (AML). Therefore, the P-gp modulators that block P-gp-mediated drug efflux have been developed, and used in combination with standard chemotherapy. In this paper, the capacity of zosuquidar, a specific P-gp modulator, to reverse chemoresistance was examined in both leukemia cell lines and primary AML blasts. The transporter protein expressions were analyzed by flow cytometry using their specific antibodies. The protein functionalities were assessed by the uptake of their fluorescence substrates in presence or absence their specific modulators. The drug cytotoxicity was evaluated by MTT test. Zosuquidar completely or partially restored drug sensitivity in all P-gp-expressing leukemia cell lines tested and enhanced the cytotoxicity of anthracyclines (daunorubicin, idarubicin, mitoxantrone) and gemtuzumab ozogamicin (Mylotarg) in primary AML blasts with active P-gp. In addition, P-gp inhibition by zosuquidar was found to be more potent than cyclosporine A in cells with highly active P-gp. These in vitro studies suggest that zosuquidar may be an effective adjunct to cytotoxic chemotherapy for AML patients whose blasts express P-gp, especially for older patients

  2. Long-term survival after allogeneic haematopoietic cell transplantation for AML in remission

    DEFF Research Database (Denmark)

    Sengeløv, H; Gerds, T A; Brændstrup, P;

    2013-01-01

    We report the results of non-myeloablative (NM) and myeloablative (MA) conditioning for haematopoietic cell transplantation in 207 consecutive AML patients at a single institution. A total of 122 patients were transplanted in first CR (CR1) and 67 in second CR (CR2). MA conditioning was given to ...

  3. Histological and immunohistochemical features of gingival enlargement in a patient with AML

    NARCIS (Netherlands)

    N. Sonoi; Y. Soga; H. Maeda; K. Ichimura; T. Yoshino; K. Aoyama; N. Fujii; Y. Maeda; M. Tanimoto; R. Logan; J. Raber-Durlacher; S. Takashiba

    2012-01-01

    Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed bo

  4. NK cell-mediated killing of AML blasts. Role of histamine, monocytes and reactive oxygen metabolites

    International Nuclear Information System (INIS)

    Blasts recovered from patients with acute myelogenous leukaemia (AML) were lysed by heterologeous natural killer (NK) cells treated with NK cell-activating cytokine-induced killing of AML blasts was inhibited by monocytes, recovered from peripheral blood by counterflow centrifugal elutriation. Histamine, at concentrations exceeding 0.1 μM, abrogated the monocyte-induced inhibition of NK cells; thereby, histamine and IL-2 or histamine and IFN-α synergistically induced NK cell-mediated destruction of AML blasts. The effect of histamine was completely blocked by the histamine H2-receptor (H2R) antagonist ranitidine but not by its chemical control AH20399AA. Catalase, a scavenger of reactive oxygen metabolites (ROM), reversed the monocyte-induced inhibition of NK cell-mediated killing of blast cells, indicating that the inhibitory signal was mediated by products of the respiratory burst of monocytes. It is concluded that (i) monocytes inhibit anti-leukemic properties of NK cells, (ii) the inhibition is conveyed by monocyte-derived ROM, and (iii) histamine reverses the inhibitory signal and, thereby, synergizes with NK cell-activating cytokines to induce killing of AML blasts. (au) 19 refs

  5. Prognostic significance of serum vascular endothelial growth factor levels in patients with acute myelogenous leukemia (AML)

    International Nuclear Information System (INIS)

    Objective: To measure the expression of vascular endothelial growth factor (VEGF) protein levels in various leukemic cell line cultures and serum of patients with AMI and assess its prognostic significance. Methods: VEGF levels in serum of 49 newly diagnosed AML patients, 10 AML patients in relapse and cultural supernatants of five leukemic cell lines (U937, K562, HL-60, TF-1 and NB4 for 48 hours) were determined by enzyme linked-immunosorbent assay (ELISA). Results: VEGF protein levels of cultural supernatants were high in all of the five leukemic cell lines (cultures), Serum VEGF levels in newly diagnosed and relapsed AML patients were 201.17 ± 110.93 pg/ml and 232.59 ±118.62 pg/ml respectively, obviously higher than those in the controls (p<0.05). In newly diagnosed patients with VEGF levels above and below the mean value 201.17 pg/ml, the complete remission (CR) rates were 48% and 77% respectively (p<0.05). Conclusion: VEGF plays a major role in the growth, proliferation and migration of hematopoietic malignancies cells. Serum VEGF levels have prognostic significance in patients with AML

  6. NK cell-mediated killing of AML blasts. Role of histamine, monocytes and reactive oxygen metabolites

    Energy Technology Data Exchange (ETDEWEB)

    Brune, M.; Mellqvist, U.H. [Sahlgren`s Univ. Hospital, Dept. of Medicine, Haematology Section, Goeteborg (Sweden); Hansson, M.; Hermodsson, S.; Hellstrand, K. [Sahlgren`s Univ. Hospital, Dept. of Virology, Goeteborg (Sweden)

    1996-10-01

    Blasts recovered from patients with acute myelogenous leukaemia (AML) were lysed by heterologeous natural killer (NK) cells treated with NK cell-activating cytokine-induced killing of AML blasts was inhibited by monocytes, recovered from peripheral blood by counterflow centrifugal elutriation. Histamine, at concentrations exceeding 0.1 {mu}M, abrogated the monocyte-induced inhibition of NK cells; thereby, histamine and IL-2 or histamine and IFN-{alpha} synergistically induced NK cell-mediated destruction of AML blasts. The effect of histamine was completely blocked by the histamine H2-receptor (H2R) antagonist ranitidine but not by its chemical control AH20399AA. Catalase, a scavenger of reactive oxygen metabolites (ROM), reversed the monocyte-induced inhibition of NK cell-mediated killing of blast cells, indicating that the inhibitory signal was mediated by products of the respiratory burst of monocytes. It is concluded that (i) monocytes inhibit anti-leukemic properties of NK cells, (ii) the inhibition is conveyed by monocyte-derived ROM, and (iii) histamine reverses the inhibitory signal and, thereby, synergizes with NK cell-activating cytokines to induce killing of AML blasts. (au) 19 refs.

  7. Teilchendetektoren Grundlagen und Anwendungen

    CERN Document Server

    Kolanoski, Hermann

    2016-01-01

    In diesem Buch werden die experimentellen Grundlagen von Teilchendetektoren und ihre Anwendung in Experimenten beschrieben. Die Entwicklung von Detektoren ist ein wichtiger Bestandteil der Teilchen-, Astroteilchen- und Kernphysik und gehört daher zum Handwerk des Experimentalphysikers in diesen Gebieten. Dieses umfassende Werk beinhaltet den kompletten Stoff für entsprechende Master-Module in der experimentellen Teilchenphysik, geht aber im Inhalt auch darüber hinaus. Zielgruppe sind Studierende, die sich in die Materie vertiefen möchten, aber auch Lehrende und Wissenschaftler, die das Buch zum Einstieg in das wissenschaftliche Arbeiten an Detektorentwicklungen verwenden können. Zielrichtung des Buches ist, die physikalischen Grundlagen für die Detektoren und ihrer verschiedenen Ausführungen so klar wie möglich und so tiefgehend wie nötig darzustellen. Die Breite des für die Detektorentwicklung nötigen Wissens umfasst viele Bereiche der Physik und Technik, von den Wechselwirkun...

  8. Accelerating the connection between experiments and models: The FACE-MDS experience

    Science.gov (United States)

    Norby, R. J.; Medlyn, B. E.; De Kauwe, M. G.; Zaehle, S.; Walker, A. P.

    2014-12-01

    The mandate is clear for improving communication between models and experiments to better evaluate terrestrial responses to atmospheric and climatic change. Unfortunately, progress in linking experimental and modeling approaches has been slow and sometimes frustrating. Recent successes in linking results from the Duke and Oak Ridge free-air CO2 enrichment (FACE) experiments with ecosystem and land surface models - the FACE Model-Data Synthesis (FACE-MDS) project - came only after a period of slow progress, but the experience points the way to future model-experiment interactions. As the FACE experiments were approaching their termination, the FACE research community made an explicit attempt to work together with the modeling community to synthesize and deliver experimental data to benchmark models and to use models to supply appropriate context for the experimental results. Initial problems that impeded progress were: measurement protocols were not consistent across different experiments; data were not well organized for model input; and parameterizing and spinning up models that were not designed for simulating a specific site was difficult. Once these problems were worked out, the FACE-MDS project has been very successful in using data from the Duke and ORNL FACE experiment to test critical assumptions in the models. The project showed, for example, that the stomatal conductance model most widely used in models was supported by experimental data, but models did not capture important responses such as increased leaf mass per unit area in elevated CO2, and did not appropriately represent foliar nitrogen allocation. We now have an opportunity to learn from this experience. New FACE experiments that have recently been initiated, or are about to be initiated, include a eucalyptus forest in Australia; the AmazonFACE experiment in a primary, tropical forest in Brazil; and a mature oak woodland in England. Cross-site science questions are being developed that will have a

  9. Farben, Zeichen und Effekte. Gestaltungstypen deutscher Kinder- und Jugendsachbuchreihen

    OpenAIRE

    Krause, Anja

    2008-01-01

    Texte und Dokumente sind Verkörperungen der Kultur. Aber nachdem das ge-schriebene Wort lange Zeit als Medium dominierte, kann eine sogenannte „ikonische Wende“ in den letzen Jahren festgestellt werden. Inhalt wird mehr und mehr durch Bilder und Symbole übertragen als durch Texte und Dokumente. Die ikonische Wende kommt mit der steigenden Wichtigkeit der neuen Medien: Fernsehen, Mobiltelefone, PC und Internet. Um die neuen Medien zu begreifen sind die Interpretation von Bildern und die Fähigk...

  10. Wald und Klima

    OpenAIRE

    Weigl, Engelhard

    2009-01-01

    Früh setzte in Europa die Wahrnehmung der Veränderung des regionalen Klimas durch Waldrodungen ein. Als erster widmete Theophrastus (372-288 v. Chr.) dem Thema des menschlichen Einflusses auf die Temperatur und die Qualität der Luft einer Region ausführliche Überlegungen. Mit ihm beginnt ein Diskurs, der durch die Entdeckung und Kolonisierung Amerikas einen enormen Aufschwung erfuhr und im letzten Drittel des 19. Jahrhunderts auf globaler Ebene seinen Höhepunkt erreichte, um dann nach der Jah...

  11. Risiko, Affekt und Emotion

    OpenAIRE

    Zinn, Jens O.

    2006-01-01

    Im theoretischen Diskurs wurde die Bedeutung von Affekten und Emotionen für Entscheidungshandeln und den Umgang mit Risiken und Unsicherheiten lange unterschätzt. Bislang dominierten Konzepte, in denen Gefühle oft einseitig als Gefahr für rationales Entscheiden verstanden werden. Ähnlich einseitig wurden im klassischen soziologischen Diskurs negative Gefühle in der Regel als Folge von sozialen Wandlungsprozessen angesehen, die eine eindeutige Erwartungsbildung beeinträchtigen würden. Neuere i...

  12. Menschenrechte und Migration

    OpenAIRE

    Schmidt, Matthias

    2014-01-01

    Der Begriff „Menschenrechte“ ist in der Migrationspolitik inzwischen nicht mehr zu überhören. Dabei ist es unmöglich, ihn auf einzelne politische Strategien und Praktiken zu reduzieren oder ihn nur bestimmten politischen Akteuren zuzuordnen. Hinsichtlich der Humanitarisierung der europäischen Außengrenzen (Walters) bleibt es in der Literatur umstritten, ob die Menschenrechte als subversive Kraft gegen Unterdrückung und Diskriminierung oder als bloßes Werkzeug zur Stabilisierung und Reprodukti...

  13. Trix und Robert Haussmann

    OpenAIRE

    Fischli, Fredi; Olsen, Niels

    2012-01-01

    Die Monografie Robert & Trix Haussmann eröffnet die Publikationsreihe STUDIOLO / Edition Patrick Frey, eine Kollaboration des Verlags mit dem Ausstellungsraum STUDIOLO. Die Kuratoren Fredi Fischli und Niels Olsen betreiben in einem Atelierhaus in Zürich ein vielfältiges Programm gegenwärtiger Kunstproduktion. Die Ausstellung The Log-O-Rhythmic Slide Rule im Frühjahr 2012 widmete sich dem Werk von Trix und Robert Haussmann und ist Ausgangspunkt für die folgende Publikation, die mit Bildern, Es...

  14. Kontrolle und Kommerzialisierung

    OpenAIRE

    Gui, Hao

    2011-01-01

    Das „China-Phänomen“ geht um die Welt. Es erntet zum einen Bewunderung wegen des schnellen Wirtschaftswachstums und der aktiven Beteiligung Chinas an der Wirtschaftsglobalisierung, löst aber zum anderen auch weltweite Empörung aus durch die Unterdrückung der Menschenrechte und der Einschränkung von Meinungs- und Pressefreiheiten. Die Annahme „Wandel durch Handel“, die in der westlichen Welt die Vorstellung impliziert, eine Volkswirtschaft würde mit zunehmendem Wohlstand konkrete, politische, ...

  15. Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice.

    Science.gov (United States)

    Ren, Mingqiang; Qin, Haiyan; Wu, Qing; Savage, Natasha M; George, Tracy I; Cowell, John K

    2016-08-15

    Acute myelogenous leukemia (AML) has an overall poor survival rate and shows considerable molecular heterogeneity in its etiology. In the WHO classification there are >50 cytogenetic subgroups of AML, many showing highly specific chromosome translocations that lead to constitutive activation of individual kinases. In a rare stem cell leukemia/lymphoma syndrome, translocations involving 8p11 lead to constitutive activation of the fibroblast growth factor receptor 1 (FGFR1) kinase. This disorder shows myeloproliferative disease with almost invariable progresses to AML and conventional therapeutic strategies are largely unsuccessful. Because of the rare nature of this syndrome, models that faithfully recapitulate the human disease are needed to evaluate therapeutic strategies. The t(8;13)(p11;q12) chromosome translocation is most common rearrangement seen in this syndrome and creates a ZMYM2-FGFR1 chimeric kinase. To understand more about the molecular etiology of AML induced by this particular rearrangement, we have created a model human CD34+ cells transplanted into immunocompromized mice which develop myeloproliferative disease that progresses to AML with a long (>12 months) latency period. As in humans, these mice show hepatospenomegaly, hypercellular bone marrow and a CD45 + CD34 + CD13+ immunophenotype. Molecular studies demonstrate upregulation of genes such as KLF4 and FLT3 that promote stemness, and overexpression of MYC, which is associated with suppression of myeloid cell differentiation. This murine model, therefore, provides an opportunity to develop therapeutic strategies against the most common subtype within these FGFR1 driven neoplasms and study the molecular etiology in more depth. PMID:27005999

  16. MICROSPONGE DELIVERY SYSTEM (MDS: A UNIQUE TECHNOLOGY FOR DELIVERY OF ACTIVE INGREDIENTS

    Directory of Open Access Journals (Sweden)

    Saurabh Kumar et al.

    2011-12-01

    Full Text Available In pharmaceutical industry, various controlled released dosage forms like solid formulation, semi solid formulation and topical preparation have more importance due to efficacy and patient compliance. Topical preparations have some disadvantages like unpleasant odour, greasiness and skin irritation and fail to reach the systemic circulation in sufficient amounts in few cases. This problem is overcome by microsponge delivery system. Microsponges are tiny sponge like spherical and highly porous micro-sized particles with a unique ability for entrapping actives. They offers programmable release active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active. These MDS’s are closely related to microspheres, and used in the sun screens, creams, ointments, over- the-counter (OTC skin care preparations, recently used in oral drug as well as biopharmaceuticals (peptides, proteins and DNA-based therapeutics drug delivery. The present review introduces microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of MDS.

  17. Heinrich Heine, Leben und Werk

    OpenAIRE

    Ásdís Lilja Hilmarsdóttir 1974

    2011-01-01

    Diese Arbeit, die von Heinrich Heine handelt, soll eine allgemeine Übersicht über sein Leben und Werk geben. Im ersten Kapitel wird von der Zeit berichtet, in der Heine lebte und in der groβe politische und gesellschaftliche Änderungen stattfanden. Im zweiten und dritten Kapitel wird zum einen die Periode in Deutschland behandelt, und zum anderen die Periode in Paris. Das vierte Kapitel ist den Gedichten gewidmet. Sie werden intepretiert und in ihrer Form erklärt. Das fünfte Kapitel handelt v...

  18. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

    OpenAIRE

    Meyers, S; Downing, J R; Hiebert, S W

    1993-01-01

    The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. We demonstrate that AML-1 is a DNA-binding protein which specifically interacts with a sequence belonging to the group of enhancer core motifs, TGT/cGGT. Electrophoretic mobility shift analysis of cell extracts identified two AML-1-containing protein-DNA c...

  19. Childhood leukemia genetic bottleneck phenomenon related to TEL-AML1: the postulation by a mathematical model

    Institute of Scientific and Technical Information of China (English)

    Petar Ivanovski; Ivan Ivanovski; Dimitrije Nikoli(c); Ivana Jovanovi(c)

    2012-01-01

    Childhood leukemia bottleneck phenomenon is the most mysterious corollary of the prenatal origin discovery of leukemogenic chromosome translocations.The bottleneck is evidence that leukemia initiation,by in utero acquired chromosome translocations that generate functional fusion genes,is far more common than the incidence rate of corresponding leukemia.For childhood TEL-AML1+ acute lymphoblastic leukemia (ALL) this equates to approximately 100 times.Practically this means that among a hundred children born with TEL-AML1 fusion gene,only one child will later in its life develop ALL.The key data necessary for unraveling of this mystery were discovered in 2002.It was the level of TEL-AML1 + cells' frequency.The bottleneck is caused by the very low body TEL-AML1 + cell count.Only one out of a thousand B cells carries TEL-AML1 fusion gene.TEL-AML1+ body cell count is low because TEL-AML1 fusion is generated at cell level of 10a to 10-4 just during the late fetal lymphopoiesis i.e.after the 36th gestational week.

  20. Niere und Hypertonie

    Directory of Open Access Journals (Sweden)

    Watschinger B

    2004-01-01

    Full Text Available Eine Hypertonie kann Ursache, aber auch Folge einer Nierenerkrankung sein. Der Blutdruck trägt zur Progression der renalen Erkrankung und zum exzessiv hohen kardiovaskulären Risiko der Patienten bei. Der Zielblutdruck bei Patienten mit einer eingeschränkten Nierenfunktion oder gleichzeitig bestehender Proteinurie unter 1 g/Tag liegt bei 130/80 mmHg, bei einer Proteinurie über 1 g/Tag 125/75 mmHg und bei Patienten mit diabetischer Nephropathie 130/80 mm Hg. ACE-Hemmer oder ARB sind Mittel der 1. Wahl, da sie stärker als andere Substanzen antiproteinurisch wirken. Um die Zielblutdruckwerte zu erreichen, ist jedoch meist eine antihypertensive Kombinationstherapie (evt. mit Diuretika und/oder Nicht-Dihydropyridin-Kalziumantagonisten, bzw. Kombination von ACE-Hemmer und ARB erforderlich.

  1. Leber und Operationsrisiko

    Directory of Open Access Journals (Sweden)

    Müller C

    2004-01-01

    Full Text Available "Erhöhte Leberwerte" stellen präoperativ ein häufiges klinisches Problem unterschiedlicher Signifikanz dar. Prognostisch sind erhöhte Einzelwerte ohne Signifikanz, bei mehreren erhöhten Leberwerten sollte präoperativ zumindest eine Abklärung mittels Virusserologie und Ultraschall erfolgen. Bei Patienten ohne klinische Symptomatik einer Lebererkrankung, bei Patienten mit chronischer Hepatitis ohne Leberzirrhose und bei Patienten mit Leberzirrhose im Stadium Child A ist bei extrahepatischen Operationen kein erhöhtes Operationsrisiko zu finden. Symptomatische Patienten mit Lebererkrankung (Child B und Child C Leberzirrhose weisen ein deutlich erhöhtes Operationsrisko auf, bei Child C Zirrhose ist eine elektive Operation aufgrund der beträchtlichen Mortalität (bis 60 % meistens als Kontraindikation zu sehen, bei Child B Zirrhosen kann nur ein problemorientiertes postoperatives Management Morbidität und Mortalität senken.

  2. Hypertonie und Bewegung

    Directory of Open Access Journals (Sweden)

    Fritsch G

    2009-01-01

    Full Text Available Die zeitgemäße Behandlung der Hypertonie wird sowohl mit Guideline-konformer Pharmakotherapie als auch mit der Optimierung von Lebensstilfaktoren durchgeführt. Dazu gehören die Reduktion des Körpergewichts und eine Verbesserung von Bewegungs- und Ernährungsverhalten. Die Veränderung von Lebensstilfaktoren folgt, so wie alle Veränderungsprozesse, definiertem stadiengerechtem Vorgehen bei der Änderung eingefahrener Verhaltensmuster. Neben den üblichen diagnostischen Verfahren untersuchen wir eine Reihe von lebensstilabhängigen Parametern wie die körperliche Leistungsfähigkeit, den Body-Mass-Index, den Körperfettgehalt sowie Kraftniveau und Gleichgewichtsfähigkeit. Daraus ergeben sich individuelle Trainings- und Ernährungsempfehlungen. In der praktischen Umsetzung begleiten wir unsere Patienten mittels Trainingstagebuch per Internet.

  3. Time to Redefine PD? Introductory Statement of the MDS Task Force on the Definition of Parkinson's Disease

    OpenAIRE

    Berg, D; Postuma, R B; Bloem, B; Chan, P; Dubois, B.; Gasser, T.; Goetz, C. G.; Halliday, G. M.; Hardy, J.; Lang, A. E.; Litvan, I.; Marek, K; Obeso, J; Oertel, W.; Olanow, C. W.

    2014-01-01

    With advances in knowledge disease, boundaries may change. Occasionally, these changes are of such a magnitude that they require redefinition of the disease. In recognition of the profound changes in our understanding of Parkinson's disease (PD), the International Parkinson and Movement Disorders Society (MDS) commissioned a task force to consider a redefinition of PD. This review is a discussion article, intended as the introductory statement of the task force. Several critical issues were i...

  4. Investigation of porosity and fractal properties of the sintered metal and semiconductor layers in the MDS capacitor structure

    Directory of Open Access Journals (Sweden)

    Skatkov Leonid

    2012-01-01

    Full Text Available MDS capacitor (metal - dielectric - semiconductor is a structure in which metal plate is represented by compact bulk-porous pellets of niobium sintered powder, and semiconductor plate - by pyrolytic layer of MnO2. In the present paper we report the results of investigation of microporosity of sintered Nb and pyrolytic MnO2 and also the fractal properties of semiconductor layer.

  5. Hepatitis C und Psyche

    Directory of Open Access Journals (Sweden)

    Moser G

    2004-01-01

    Full Text Available Hepatitis C ist ein globales gesundheitliches Problem und eine der häufigsten infektiösen Erkrankungen weltweit. Nur die Hälfte der Betroffenen leidet nach einer Infektion unter Symptomen, die sie ärztliche Hilfe aufsuchen läßt, weshalb es oft Zufallsbefunde sind, die zu einer Diagnose führen. Die häufigsten Beschwerden der Betroffenen in frühen Stadien der Erkrankung sind unspezifisch und führen zu einer reduzierten Lebensqualität mit verminderter Leistungsfähigkeit und psychischer Beeinträchtigung. Wird dann die Diagnose gestellt, fühlen sich die Patienten durch die infektiöse Erkrankung häufig stigmatisiert, manche leiden unter immensen Schuldgefühlen und viele erleben ihre Erkrankung als fatal. In zahlreichen Studien konnte gezeigt werden, daß Patienten mit Hepatitis C unter einer deutlich reduzierten Lebensqualität sowie häufigen Depressionen und Angstsymptomen leiden, welche durch die derzeit gängige Therapie der Hepatitis C mit Interferon-alpha und Ribavirin zusätzlich induziert oder noch verstärkt werden können. Aber mehrere Studien weisen auch darauf hin, daß die Lebensqualität der Betroffenen weniger mit dem Grad der Hepatitis als mit den psychosozialen Folgen wie der psychiatrischen Co-Morbidität, dem Krankheitsverstehen und den krankheitsbezogenen Sorgen wie Stigmatisierung korreliert. Umso wichtiger scheint nach Mitteilung der Diagnose die Evaluation der psychosozialen Situation der Betroffenen. Abgesehen von einer medikamentösen Therapie der Hepatitis ist es entsprechend dem bio-psycho-sozialen Modell der Erkrankung daher wichtig, bei Bedarf eine integrierte psychosomatische Betreuung anzubieten und/oder eine interdisziplinäre Kooperation mit FachärztInnen der Psychiatrie zu etablieren.

  6. Harnsteinbildung und metabolisches Syndrom

    OpenAIRE

    Graeff, Dorothee

    2013-01-01

    Die Urolithiasis kann heute als Volkskrankheit gelten. Sie hat damit den gleichen Stellenwert wie die arterielle Hypertonie, die Adipositas und der Diabetes mellitus, alle drei Symptome des metabolischen Syndroms. Anhand einer retrospektiven Datenanalyse wurde untersucht, ob im zugrundeliegenden Patientenkollektiv mit 472 Harnsteinbildnern eines oder mehrere Symptome des metabolischen Syndroms das Risiko für eine Harnsteinbildung erhöhen. Von 327 Männern und 145 Frauen waren 154 Personen adip...

  7. Goethe und die Architekturtheorie

    OpenAIRE

    Büchsenschuß, Jan

    2009-01-01

    Trotz einer Vielzahl sekundärliterarischer Beiträge zum Thema ‚Goethe und die Baukunst’ und einer seit Jahren geforderten Bearbeitung des architekturtheoretischen Gehalts im Werk Goethes, gibt es bis auf den heutigen Tag keine umfassende Arbeit hierüber. In dieser Dissertation werden nun Goethes Beiträge zur Architektur detailliert untersucht; der Schwerpunkt ruht hierbei auf den architekturtheoretischen Aspekten. Im ersten Teil der Dissertation wird ein biographisch-chronologischer Überblick...

  8. Europa und die Informationsgesellschaft

    OpenAIRE

    Marahrens, Oliver

    2007-01-01

    Bei dem Artikel handelt es sich um einen Bericht zum 3. SuMa-eV-Forum am 28.09.2006 in Berlin. Die Tagung stand unter dem Titel "Suchmaschinen: In Technik, Wirtschaft und Medienkunst". Dieses Dokument ist die Eigenarchivierung des Autors eines in der Ausgabe 1/2007 der Zeitschrift für Bibliothekswesen und Bibliographie (ZfBB, Klostermann Verlag, ISSN 0044-2380) erschienenen Artikels.

  9. Alexithymie und Diabetes mellitus

    OpenAIRE

    Naundorf, Katrin

    2013-01-01

    Hintergrund: Der Verlauf der Diabetes-Erkrankung wird unter anderem durch individuelles Verhalten maßgeblich bestimmt. Der Umgang mit der Erkrankung und deren Anforderungen setzt die Verfügbarkeit von hinreichenden krankheitsspezifischen Informationen voraus, welche etwa über Schulungen vermittelt werden können. Zusätzlich scheinen psychologische Bedingungen, wie etwa die Fähigkeit zur Selbstfürsorge und der angemessene Umgang mit den eigenen Bedürfnissen, weitere wichtige Faktoren zu sein...

  10. Fremdenfeindlichkeit und Bildung

    OpenAIRE

    Wiezorek, Christine; Fritzsche, Sylke

    2007-01-01

    Im Aufsatz wird dem Zusammenhang von Fremdenfeindlichkeit und Bildung vor dem Hintergrund interethnischer Kontakte in der Schule nachgegangen. Neuere qualitative und quantitative Forschungsergebnisse triangulierend wird aufgezeigt, dass der häufig reproduzierte Befund der Ausprägung von Fremdenfeindlichkeit in Abhängigkeit zum Bildungsgrad zu kurz greift. Exemplarisch wird auch verdeutlicht, dass die für eine demokratische Haltung unerlässliche Fähigkeit der Anerkennung des Anderen als Gleich...

  11. Epilepsiechirurgie und Neurostimulation

    Directory of Open Access Journals (Sweden)

    Baumgartner C

    2009-01-01

    Full Text Available Zirka 35 % aller Epilepsiepatienten leiden an einer medikamentös therapieresistenten Epilepsie. Für diese Patienten stellen die Epilepsiechirurgie (als potenziell kurative Methode und Neurostimulationsverfahren (als palliative Verfahren wertvolle Behandlungsoptionen dar. Bei den epilepsiechirurgisch behandelbaren Epilepsiesyndromen lassen sich (1 Epilepsien mit fokalen Pathologien, bei denen eine umschriebene Resektion durchgeführt werden kann; (2 Epilepsien, die extensive, oft multilobäre Resektionen oder Hemisphärektomien erfordern und (3 Epilepsien, bei denen lediglich eine Diskonnektionsoperation sinnvoll ist, unterscheiden. Voraussetzung für einen epilepsiechirurgischen Eingriff ist eine exakte präoperative Epilepsiediagnostik, wobei die epileptogene Zone und essenzielle Hirnregionen genau lokalisiert werden müssen. Dadurch werden prognostische Aussagen bezüglich der postoperativen Anfallskontrolle und eine Abschätzung des Risikos funktioneller Defizite ermöglicht. Gemäß einer rezenten Metaanalyse ist der mediane Anteil der langfristig anfallsfreien Patienten nach Temporallappenresektionen 66 %, nach okzipitalen und parietalen Resektionen je 46 % und nach frontalen Resektionen 27 %. Die Vagus- Nerv-Stimulation (VNS ist eine klinisch etablierte Methode für Patienten, die für einen epilepsiechirurgischen Eingriff nicht infrage kommen oder bei denen eine solche Operation nicht zum Erfolg geführt hat. Mit der VNS können Responderraten (Anfallsreduktion 50 % von 30–40 % erzielt werden, wobei die Wirksamkeit über die ersten 18–24 Monate kontinuierlich zunimmt, um dann ein stabiles Plateau zu erreichen. Bei der direkten Hirnstimulation, die sich derzeit noch im experimentellen Stadium befindet, kann einerseits eine direkte Stimulation der epileptogenen Zone und somit kortikaler Strukturen erfolgen, andererseits können auch tiefe Hirnstrukturen mit dem Ziel der Modifikation der Anfallsentstehung und/oder Ausbreitung stimuliert

  12. Osteoporose und Antikoagulantientherapie

    Directory of Open Access Journals (Sweden)

    Sieghart S

    2003-01-01

    Full Text Available Die Langzeittherapie mit unfraktioniertem Heparin (UF-Heparin bei Patienten mit erhöhtem Thromboembolie-Risiko hat in verschiedenen klinischen Studien in Abhängigkeit mit der Dosierung und Dauer der Therapie einen negativen Effekt auf den Knochenstoffwechsel und Anstieg des vertebralen Frakturrisikos gezeigt. Dagegen konnten mit dem Einsatz von niedermolekularen Heparinen (LMW-Heparin in der präventiven Dosierung weder im Tierversuch noch in klinischen Studien negative Einflüsse auf die Knochenneubildung, Knochendichte und Frakturhäufigkeit beobachtet werden. Weitere prospektive Studien mit therapeutischen Dosierungen von LMW-Heparinen in der Langzeittherapie sind notwendig, um einen Anstieg des Frakturrisikos auszuschließen. Epidemiologische Studien zeigen, daß bei Vitamin K-Mangel und/oder gestörter Resorption der Anteil des untercarboxylierten Osteokalzins ansteigt und das Frakturrisiko erhöht ist. Unter Antikoagulantien-Therapie mit Cumarinen wird in verschiedenen Studien die Knochendichte teils erniedrigt, teils unverändert gefunden, so daß in erster Linie vermutlich die Knochenqualität durch Vitamin K beeinflußt wird. Eine kürzlich erschienene Studie bestätigt den Anstieg des vertebralen Frakturrisikos und das Risiko für Rippenfrakturen in Abhängigkeit von der Dauer der Antikoagulantientherapie. Eine sorgfältige Evaluierung des Knochenstoffwechsels bei Osteoporose-Risikopatienten wird daher vor und während der Langzeittherapie mit Antikoagulantien empfohlen. Menatetrenone, ein synthetisch hergestelltes Derivat von Vitamin K2, wurde erstmals in Japan als Therapeutikum bei Patienten mit postmenopausaler Osteoporose eingesetzt. Das vertebrale Frakturrisiko war nach 2 Jahren Therapie signifikant reduziert, die Gerinnungsparameter waren unbeeinflußt. Weitere Studien sind notwendig, um die vielfältigen Funktionen von Vitamin K und ihre Bedeutung für den Knochenstoffwechsel zu erforschen sowie ihren Stellenwert in der

  13. Kinder- und Laienkunst

    OpenAIRE

    Jooss, Birgit

    1998-01-01

    1912 gaben Wassily Kandinsky und Franz Marc den Almanach "Der Blaue Reiter" heraus, der bis heute als eine der bedeutendsten programmatischen Schriften zur Kunst des 20. Jahrhunderts gilt. Neben wichtigen Texten nahmen auch die Abbildungen einen herausgehobenen Stellenwert ein. Kandinsky und Marc interessierten sich auch sehr für Kinderzeichnungen. Selbst kinderlos geblieben, hatten sie schon früh begonnen, Zeichnungen von Kindern zu sammeln, die Aufnahme in den Almanach fanden. Dieser war da...

  14. Sprichwort und Wortspiel

    Directory of Open Access Journals (Sweden)

    Željka Matulina

    2015-09-01

    Full Text Available Als eine idiomatische Bildung mit dem Satz-Status wird das Sprichwort meist aus der lexikographischen Diskussion ausgeschlossen, weil es Satz ist, auf der anderen Seite wird es im Rahmen der Syntax nicht behandelt, weil es Idiom ist, und so hat das Überprüfen und Testen seiner grammatischen Strukturiertheit wenig Sinn. Die Spezifik des Sprichwort-Satzes liegt in der linear-horizontalen Kombinatorik seiner Konstituenten. Die Reihenfolge der Sprichwort-Konstituenten ist streng festgelegt.

  15. 12. Asylpolitik und Migrationspolitik

    OpenAIRE

    Fibbi, Rosita

    2010-01-01

    Die traditionell in der Innenpolitik angesiedelte Migrationsthematik hat bereits vor Jahren den nationalen Rahmen gesprengt und steht in einem immer engeren Zusammenhang mit verschiedenen aussenpolitischen Fragestellungen. Auch in der Schweiz hat sich diese Erkenntnis durchgesetzt, und zu Beginn des 21. Jahrhunderts wurde versucht, zusammen mit zahlreichen anderen Ländern den Dialog über die Bewältigung der Migrationsströme zu vertiefen. Die daraus hervorgegangenen Initiativen stiessen intern...

  16. Neovaskularisation und Tissue Engineering

    OpenAIRE

    Nguyen The, Hoang

    2010-01-01

    Präfabrikation von axial neovaskularisierten Hautlappen, die einen weiteren Entwicklungsschritt in der rekonstruktiven Chirurgie darstellen und durch deren Anwendung auf den Bereich des “Tissue Engineerings“ sich vitale, dreidimensionale Strukturen originalgetreu züchten lassen. In experimentellen Studien am Kaninchen wurde die Neovaskularisation bei 156 Bauchhautlappen mit unterschiedlichen Modellvarianten des implantierten Gefäßstiels nach 4, 8, 12, 16 und 20 Tagen der Präfabrikation unters...

  17. "Wahrhaftigkeit, Barmherzigkeit und Nachsicht"

    OpenAIRE

    Zhou, Lei

    2001-01-01

    Inhaltsübersicht I. Kurzer Überblick über die Geschichte von Falun Gong 1. Was ist Falun Gong? 2. Die Entwicklung von Falun Gong 3. Der Wendepunkt: Die friedliche Kundgebung der Zehntausend am 25. April 1999 in Peking 4. Verhaftungen und Verbot II. Systematische Verfolgung durch die Staatsgewalt 1. Folter mit Todesfolge 2. Zwangseinweisungen in psychiatrische Anstalten zur "Umerziehung" 3. Brutalitäten gegenüber Inhaftierten 4. Unmenschlichkeit und gesellschaftlicher Terror 5. Duldung kollekt...

  18. Negative und positive Integration

    OpenAIRE

    Scharpf, F.

    2008-01-01

    Der Beitrag beschäftigt sich mit den Wirkungen der europäischen Integration auf das Grundproblem traditioneller wie moderner Politischer Ökonomie: Die Arbeitsteilung zwischen Staat und Markt. Im Mittelpunkt steht die "negative Integration" und ihr einzigartiger Erfolg bei der Beseitigung der in den Nachkriegsjahrzehnten gewonnenen Kontrolle des Nationalstaates über seine ökonomischen Außengrenzen. Durch die "Konstitutionalisierung" des Wettbewerbsrechts haben die Europäische Kommission ...

  19. Resilienz - Kritik und Perspektiven

    OpenAIRE

    Gabriel, Thomas

    2005-01-01

    Der Begriff der Resilienz umschreibt die menschliche Widerstandsfähigkeit gegenüber belastenden Lebensumständen und stellt somit einen positiven Gegenbegriff zur Vulnerabilität dar. Aus der hier entwickelten Perspektive erscheint das Wissen um diese relative "Unverletzbarkeit" als eine fruchtbare Ergänzung zu vorliegenden Wissensbeständen über Risikofaktoren in Sozialisations- und Erziehungsprozessen. Anhand ausgewählter empirischer Studien wird das Konzept der Resilienz zugleich entmythologi...

  20. Sozialepidemiologie und Zahnmedizin

    OpenAIRE

    Bauch, Jost; Micheelis, Wolfgang

    1998-01-01

    Aus bevölkerungsrepräsentativen Studien des 'Deutschen Instituts für Zahnmedizin' der Jahre 1989 bis 1993 werden Einzelbefunde zum Kariesbefall aus unterschiedlichen Sozialschichten sowie im Vergleich zwischen Ost- und Westdeutschland vorgestellt und kommentiert. Die sozialepidemiologische Forschung in der Zahnmedizin hat dabei in den letzten Jahren der Oralprophylaxe viele Impulse gegeben. So entsteht heute ein neues Paradigma einer präventiv ausgerichteten Zahnheilkunde mit Hinweisen auf di...

  1. Internationalisierungsstrategien und Unternehmensreorganisationen

    OpenAIRE

    Seitz, Beate

    2000-01-01

    Die Anforderungen an die produzierenden Unternehmen zur Sicherung ihres Standortes seit den achtziger Jahren lassen sich kurz mit den Stichworten verschärfter Wettbewerb, fortschreitende Globalisierung bzw. Internationalisierung der Wirtschaft und immer schnellerer technologischer Wandel beschreiben (vgl. Porter, 1985; Kanter, 1989). Darüber hinaus trägt auch die veränderte politische Lage der neunziger Jahre zu wachsenden Unsicherheiten hinsichtlich von Investitions- und mö...

  2. Vorzugsaktien, Ausgliederung und Konzernfinanzierung

    OpenAIRE

    Baums, Theodor

    1993-01-01

    Vorzugsaktien ohne Stimmrecht sind ein hybrides Finanzierungsinstrument zwischen der stimmberechtigten Stammaktie auf der einen Seite und der Schuldverschreibung auf der anderen. Ebenso wie die reguläre Aktie gewährt die Vorzugsaktie ihrem Inhaber eine ergebnisabhängige Teilhabe am Residuum, während sie - insofern der Schuldverschreibung vergleichbar - zumindest im praktischen Regelfall ihrem Inhaber kein Stimmrecht und damit nicht die Möglichkeit gibt, im Rahmen der sonst den Eigenkapitalgeb...

  3. Rilke und die Musik

    OpenAIRE

    Deinert, Herbert

    2010-01-01

    Rilke war im gebräuchlichen Sinne des Wortes unmusikalisch. Er hat das selbst wiederholt zugegeben. Er behielt keine Melodie, so einfach sie sein mochte, und so oft man sie ihm auch vorspielte. Auch seine Freunde berichten von diesem Zug. Hinzu kam eine tiefe Skepsis der Musik gegenüber, in der er etwas Verführendes und Berauschendes sah, was ihn zu einer allerdings kurzfristigen völligen Ablehnung dieser Kunstgattung führte.

  4. Korruption und Gewissenhaftigkeit

    OpenAIRE

    Schön, Felix; Litzcke, Sven Max; Linssen, Ruth; Schilling, Jan

    2011-01-01

    Die nachfolgend berichteten Ergebnisse basieren auf einem vignettenbasierten 2x2-Szenario-Experiment, in das die Situationsfaktoren Entdeckungswahrscheinlichkeit und Vorteilswert sowie die Personenfaktoren Organisationaler Zynismus, das Fünf-Faktoren-Modell der Persönlichkeit und Intelligenz einbezogen wurden. In diesem Bericht werden vorrangig die Ergebnisse zur Persönlichkeitsdimension Gewissenhaftigkeit vorgestellt, einem der Faktoren des Fünf-Faktoren-Modells der Persönlichkeit. Diese Erg...

  5. Trends und Perspektiven

    OpenAIRE

    Burda, Michael C.; Kvasnicka, Michael

    2005-01-01

    Zeitarbeit bietet Unternehmen ein zusätzliches Instrument zur flexiblen Personalanpassung. Zudem eröffnet sie Berufsanfängern und vormalig Beschäftigten einen alternativen Weg in den Arbeitsmarkt. Der vorliegende Aufsatz analysiert die wirtschaftliche Bedeutung, die wechselnden gesetzlichen Rahmenbedingungen und die ökonomische Entwicklung der Zeitarbeit am deutschen Arbeitsmarkt. Sinkende Löhne bei steigenden Beschäftigungsanteilen deuten auf eine Ventilfunktion für den regulären Arbeitsmark...

  6. Edition und Open Access

    OpenAIRE

    Graf, Klaus

    2009-01-01

    Der Wiener Kanoniker Ladislaus Sunthaim, einer der um 1500 am historisch-genealogischen Forschungsprojekt Maximilians I. tätigen Gelehrten, wurde von Fritz Eheim - unter anderem in seiner leider ungedruckt gebliebenen Prüfungsarbeit am IfÖG 1950 - als einer jener reisenden Historiker in der Zeit des Humanismus porträtiert, die unter anderem in Klosterarchiven und -bibliotheken nach verborgenen Quellenschätzen fahndeten. Im Zeitalter von Kopie und Mikrofilm ist es wesentlich einfacher geworden...

  7. Klimaschutz und erneuerbare Energien

    OpenAIRE

    Baumgart, Sabine; Kötter, Kirsten

    2013-01-01

    "Der Ausbau erneuerbarer Energien hat auf regionaler Ebene im Rahmen des Klimaschutzes an Bedeutung gewonnen. Angesichts der dezentralen unternehmerischen Aktivitäten für die räumliche Umsetzung der energiepolitischen Ziele, Leitbilder und Strategien rückt die damit verbundene Flächeninanspruchnahme als räumliche Dimension ins Blickfeld. Als überörtliche und überfachliche Institution ist die Regionalplanung gefragt, den Ausbau der unterschiedlichen raumbedeutsamen erneuerbaren Energien mit ih...

  8. t(8;21)(q22;q22) fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression

    OpenAIRE

    Okumura, Akiko J.; Peterson, Luke F.; Okumura, Fumihiko; Boyapati, Anita; Zhang, Dong-Er

    2008-01-01

    Chromosome abnormalities are frequently associated with cancer development. The 8;21(q22;q22) chromosomal translocation is one of the most common chromosome abnormalities identified in leukemia. It generates fusion proteins between AML1 and ETO. Since AML1 is a well-defined DNA-binding protein, AML1-ETO fusion proteins have been recognized as DNA-binding proteins interacting with the same consensus DNA-binding site as AML1. The alteration of AML1 target gene expression due to the presence of ...

  9. IDENTIFICATION AND CHARACTERIZATION OF NOVEL AML1-ETO FUSION TRANSCRIPTS IN PEDIATRIC t(8;21) ACUTE MYELOID LEUKEMIA: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP

    OpenAIRE

    LaFiura, Katherine M.; Edwards, Holly; Taub, Jeffrey W.; Matherly, Larry H.; Fontana, Joseph A; Mohamed, Anwar N; Ravindranath, Yaddanapudi; Ge, Yubin

    2008-01-01

    t(8;21)(q22;q22) results in the AML1-ETO (A1E) fusion gene and is a common cytogenetic abnormality in acute myeloid leukemia (AML). Although insertions at the breakpoint region of the A1E fusion transcripts have been reported, additional structural alterations are largely uncharacterized. By RT-PCR amplifications and DNA sequencing, numerous in-frame and out-of-frame AML1b-ETO and AML1c-ETO transcripts were identified in 13 pediatric t(8;21) AMLs, likely resulting from alternate splicing, int...

  10. Therapy-Related Myelodysplastic Syndrome Following Treatment for Childhood Acute Lymphoblastic Leukemia: Outcome of Patients Registered in the EWOG-MDS 98/06 Studies

    DEFF Research Database (Denmark)

    Strahm, Birgitte; Amann, Roland; De Moerloose, Barbara;

    Objective: Therapy-related myelodysplastic syndrome (tMDS) following treatment of childhood acute lymphoblastic leukemia (ALL) is one of the most frequently observed secondary malignancies in survivors of childhood cancer. Allogeneic stem cell transplantation (SCT) is the only curative treatment....... This analysis was performed to asses the outcome of patients with tMDS following treatment for childhood ALL reported to the EWOG-MDS study group. Patients and Transplant Procedure: Forty-three patients (19 male/24 female) were diagnosed with tMDS between August 1989 and August 2009. The median age at diagnosis......, cyclophosphamide and melphalan (Bu/Cy/Mel) (23), an alternative busulfan based regimen (6), a radiation based regimen (5) or others (3). Results: After a median follow up of 4.1 (0.5 – 9.4) years, 14 patients are alive in first complete remission (CR). Seventeen patients developed relapse after a median time...

  11. Attitude Determination and Control System (ADCS) and Maintenance and Diagnostic System (MDS): A maintenance and diagnostic system for Space Station Freedom

    Science.gov (United States)

    Toms, David; Hadden, George D.; Harrington, Jim

    1990-01-01

    The Maintenance and Diagnostic System (MDS) that is being developed at Honeywell to enhance the Fault Detection Isolation and Recovery system (FDIR) for the Attitude Determination and Control System on Space Station Freedom is described. The MDS demonstrates ways that AI-based techniques can be used to improve the maintainability and safety of the Station by helping to resolve fault anomalies that cannot be fully determined by built-in-test, by providing predictive maintenance capabilities, and by providing expert maintenance assistance. The MDS will address the problems associated with reasoning about dynamic, continuous information versus only about static data, the concerns of porting software based on AI techniques to embedded targets, and the difficulties associated with real-time response. An initial prototype was built of the MDS. The prototype executes on Sun and IBM PS/2 hardware and is implemented in the Common Lisp; further work will evaluate its functionality and develop mechanisms to port the code to Ada.

  12. Quality of health in survivors of childhood acute myeloid leukemia treated with chemotherapy only: A NOPHO-AML study

    DEFF Research Database (Denmark)

    Molgaard-Hansen, Lene; Glosli, Heidi; Jahnukainen, Kirsi;

    2010-01-01

    care services, health experience, social outcomes, and lifestyle behavior of AML survivors with that of their sibling controls. METHODS: This population-based study included 138 children treated for AML according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO)-AML-84, -88, and -93...... survivors had no increased rate of hospitalization compared with sibling controls, but were more often receiving prescription drugs, especially for asthma (23% vs. 9%, P¿=¿0.03). Self-reported health experience was excellent or very good in 77% and comparable with that of siblings. Educational achievement...

  13. EVI1 is critical for the pathogenesis of a subset of MLL-AF9–rearranged AMLs

    OpenAIRE

    Bindels, Eric M. J.; Havermans, Marije; Lugthart, Sanne; Erpelinck, Claudia; Wocjtowicz, Elizabeth; Krivtsov, Andrei V.; Rombouts, Elwin; Armstrong, Scott A; Taskesen, Erdogan; Haanstra, Jurgen R.; Beverloo, H. Berna; Döhner, Hartmut; Hudson, Wendy A.; Kersey, John H.; Delwel, Ruud

    2012-01-01

    The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band 3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 rearrangements. In the current study, we showed, in a large AML cohort carrying 11q23 translocations, that ∼ 43% of all mixed lineage leukemia (MLL)–rearranged leukemias are EVI1pos. High EVI1 expression occurs in AMLs expressing the MLL-AF6, -AF9, -AF10, -ENL, or -ELL fusion genes. In addition, we present evidence that EVI1pos ...

  14. Optical spectroscopy investigation of peptides issued from the AML1-ETO–E-protein complex relevant to acute myeloid leukemia

    OpenAIRE

    Porumb, H.

    2008-01-01

    The expression of AML1-ETO, resulting from the t(8; 21) chromosomal translocation causes 15% of acute myeloid leukaemias. The NHR2 region of ETO, bearing the motif LxxLL, is involved in the oligomerisation of the AML1-ETO. “Peptide NHR2” is one of the objects of the present investigation. The TAFH region of ETO may recruit AML1-ETO to transcription activators, such as E-protein. “Peptide TAFH” is another object of the present investigation. TAFH interacts with E-protein through the AD1 domain...

  15. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.

    OpenAIRE

    Hiebert, S W; Sun, W; Davis, J. N.; Golub, T; Shurtleff, S; Buijs, A; Downing, J R; Grosveld, G; Roussell, M F; Gilliland, D G; Lenny, N; Meyers, S

    1996-01-01

    The t(12;21) translocation is present in up to 30% of childhood B-cell acute lymphoblastic and fuses a potential dimerization motif from the ets-related factor TEL to the N terminus of AML1. The t(12;21) translocation encodes a 93-kDa fusion protein that localizes to a high-salt- and detergent-resistant nuclear compartment. This protein binds the enhancer core motif, TGTGGT, and interacts with the AML-1-binding protein, core-binding factor beta. Although TEL/AML-1B retains the C-terminal doma...

  16. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation.

    OpenAIRE

    Kitabayashi, I; A Yokoyama; Shimizu, K; Ohki, M

    1998-01-01

    The AML1 transcription factor and the transcriptional coactivators p300 and CBP are the targets of chromosome translocations associated with acute myeloid leukemia and myelodysplastic syndrome. In the t(8;21) translocation, the AML1 (CBFA2/PEBP2alphaB) gene becomes fused to the MTG8 (ETO) gene. We previously found that the terminal differentiation step leading to mature neutrophils in response to granulocyte colony-stimulating factor (G-CSF) was inhibited by the ectopic expression of the AML1...

  17. Fortschrittsidee und Politische Vision

    Directory of Open Access Journals (Sweden)

    Georg Hubmann

    2014-12-01

    Full Text Available Das Konzept des Fortschritts und die Entstehung politischer Visionen sind immanent miteinander verknüpft. Die Idee eines Fortschreitens der Zeit und eines damit verbundenen Wandels des sozialen Umfelds ist Vorbedingung, um politische Argumente auf Basis normativer Projektionen überhaupt denken zu können. Darüber hinaus prägen Vorstellungen vom Fortschritt unsere politischen Prämissen ebenso wie die politische Rhetorik. Dieser Beitrag vertritt die These, dass gerade heute, in Zeiten, in denen der tatsächliche oder vermeintliche Fortschritt kritisch reflektiert und neu bewertet wird, ein geklärtes Fortschrittsverständnis für eine selbstbewusste Politikgestaltung überaus nützlich sein kann. Er versucht also das Nachdenken über den Fortschritt insofern zu befördern, als grundsätzliche Dimensionen und Dichotomien des Fortschritts herausgearbeitet werden. Diese Auseinandersetzung erfolgt mit dem Ziel, den Begriff Fortschritt neu zu verorten, ihm so neue Brauchbarkeit für die politische Praxis zu verleihen und zugleich zu zeigen, mit welchen Schwierigkeiten und grundsätzlichen Fragen der Bezug auf den „Fortschritt“ verbunden ist.

  18. Psychopharmaka und sexuelle Dysfunktion

    Directory of Open Access Journals (Sweden)

    Assem-Hilger E

    2005-01-01

    Full Text Available Moderne psychopharmakologische Therapieansätze reduzieren psychiatrische Zielsymptome und berücksichtigen in zunehmendem Maße prognostisch bedeutsame Faktoren wie subjektive Lebensqualität und soziale Reintegration. Im Rahmen der Complianceforschung wurden in den letzten Jahren sexuelle Nebenwirkungen von Psychopharmaka, insbesondere von antidepressiven und antipsychotischen Substanzen, vermehrt untersucht. Die komplexen Wechselwirkungen zwischen psychosozialen, biologischen und pharmakologischen Faktoren im Rahmen psychiatrischer Erkrankungen können die ätiologische Zuordnung sexueller Dysfunktionen erschweren. Als gesichert gilt jedoch, daß Substanzen mit vorwiegend serotonergem Wirkmechanismus mit vergleichsweise hohen Inzidenzen sexueller Nebenwirkungen assoziiert sind. Substanzen mit postsynaptischer Serotonin-2-Rezeptorblockade oder alpha-adrenolytischer Wirkkomponente zeichnen sich hingegen durch das weitgehende Fehlen sexueller Dysfunktionen aus. Innerhalb der Gruppe der Antipsychotika sind sexuelle Nebenwirkungen vor allem bei Präparaten mit ausschließlicher oder vorwiegender Dopamin-2-Rezeptorblockade und damit assoziierten endokrinologischen Nebenwirkungen zu erwarten. Bei Auftreten iatrogen induzierter Sexualstörungen sind gegenregulierende Maßnahmen stets nach strenger individueller Nutzen-Risiko-Abwägung zu treffen. Der vorliegende Artikel bietet einen Überblick über die aktuelle Literatur zu Pathophysiologie, Inzidenz und klinischem Management psychopharmakainduzierter Sexualstörungen.

  19. Mobiler Lernalltag - Erfahrungsbasiert und informell

    OpenAIRE

    Specht, Marcus

    2013-01-01

    Specht, M. (2013, 26 April). Mobiler Lernalltag - Erfahrungsbasiert und informell. Invited talk given at the Speedlab Mobile Learning organized by the Kooperative Berlin und Bundeszentrale für politische Bildung, Hannover, Germany.

  20. Nichtlineare Faseroptik Grundlagen und Anwendungsbeispiele

    CERN Document Server

    Engelbrecht, Rainer

    2015-01-01

    Faseroptische Komponenten und Systeme sind heute unverzichtbar im Bereich der Datenübertragung, der Sensorik und Messtechnik, der Materialbearbeitung und in der Medizintechnik. Bei hohen Lichtleistungen in Glasfasern mit kleinen Querschnitten treten dabei nichtlineare optische Effekte auf, die in einigen Anwendungen gezielt genutzt werden können, aber in anderen Fällen störend sind. Aufbauend auf den Grundlagen der linearen Ausbreitung von Lichtwellen in Glasfasern werden in diesem Buch die nichtlinearen faseroptischen Effekte grundlegend und systematisch behandelt. Schwerpunkte sind dabei die Auswirkungen und Anwendungen der stimulierten Raman- und Brillouin-Streuung. Spezielle Aspekte der nichtlinearen Faseroptik werden am Beispiel der Raman-Faserlaser vertieft. Das Buch zeichnet sich durch fundierte theoretische Grundlagen, Angabe repräsentativer Zahlenwerte und anschauliche Beispiele aus. In kurzen Exkursen werden Zusammenhänge aufgezeigt und weiterführende Informationen gegeben. Zahlreiche Litera...

  1. Bildungspotenziale digitaler Spiele und Spielkulturen

    Directory of Open Access Journals (Sweden)

    Johannes Fromme

    2008-12-01

    Full Text Available Der Beitrag konzentriert sich auf den Bereich des informellen und selbstgesteuerten Lernens im Kontext von Computerspielen und Computerspielkulturen und verfolgt das Ziel, ausgehend von einer Untersuchung ausgewählter Bildungspotenziale Grundlagen für die Einschätzung und Bewertung von Computerspielen sowie ihren Einsatz in pädagogischen Kontexten anzubieten. Es wird dazu zunächst begrifflich zwischen Lernen und Bildung unterschieden, um einer engen instrumentellen Perspektive zu entkommen. Anschliessend werden unterschiedliche Arten von digitalen Bildungsräumen thematisiert, bevor spezifische Bildungspotenziale von Singleplayer-Spielen und von community- basierten Multiplayer-Spielen genauer erläutert und diskutiert werden. Abschliessend plädiert der Beitrag dafür, die Kluft zwischen formalen und informellen Lernumgebungen zu überbrücken.

  2. Problemmodelle und Bionik als Methode

    OpenAIRE

    Gramann, Jens

    2007-01-01

    Die vorliegende Arbeit beschäftigt sich mit der Integration kognitionswissenschaftlicher Erkenntnis in die Konstruktionsforschung. Dazu werden zunächst einige Modelle und Einzelbefunde der Kognitionspsychologie dargestellt. Vor diesem Hintergrund werden Arbeitsmethoden zur Problemmodellierung und Lösungssuche diskutiert und bewertet. Aus dieser Betrachtung resultieren Ansatzpunkte für die Weiterentwicklung von Methoden zur Problemmodellierung und methodische Ansätze zur Lösungssuche mittels B...

  3. Planung und Risikobewertung projektspezifischer Produktionsnetzwerke

    OpenAIRE

    Fabig, Christian; Derno, Marie; Borkenhagen, Sophie; Schmidt, Thorsten; Lasch, Rainer

    2013-01-01

    Bei Einzel‐ und Kleinserienfertigung müssen sowohl langfristige Kooperationspartner als auch auftrags-spezifische, internationale Partner und Lieferanten in die Produktion komplexer Investitionsgüter einbezogen werden. Zunehmend sind kleine und mittlere Unternehmen (KMU) herausgefordert nicht nur technische Komponenten zu liefern, sondern die komplette Projektplanung zu realisieren. Im Forschungsprojekt „PIP“ soll ein Verfahren entwickelt werden, das gerade KMU des Maschinen- und Anlagenbaus ...

  4. Schriftenreihe Werkstoffe und werkstofftechnische Anwendungen

    OpenAIRE

    2013-01-01

    Die Schriftenreihe „Werkstoffe und werkstofftechnische Anwendungen“ behandelt Themengebiete der Werkstoffwissenschaft und -technik, der Oberflächentechnik sowie deren industriellen Anwendungen. Es werden vorrangig aktuelle Forschungsergebnisse der Professuren Verbundwerkstoffe und Oberflächentechnik/Funktionswerkstoffe des Instituts für Werkstoffwissenschaft und Werkstofftechnik der TU Chemnitz vorgestellt. Weiterhin sind in der Schriftenreihe die Tagungsbände des jährlich am Institut stattfi...

  5. CLILiG und Musikunterricht

    OpenAIRE

    Jung, Merle; Eerme, Mari

    2015-01-01

    Der Einsatz von Musik und Liedern im Sprachunterricht ist seit der Entwicklung der kommunikativen Methoden ein beliebtes Thema in der Fremdsprachendidaktik. Musik und Sprache haben Ähnlichkeiten bei den kognitiven Verarbeitungsprozessen und der gedächtnisstützende Einfluss der Musik und ihr Nutzen für das Sprachenlernen sind allgemein bekannt. Dieser Nutzen wird aber meistens nur aus der (fremd)sprachlichen Perspektive gezogen, die musikalische Erziehung der Lernenden bleibt im Hintergrund. D...

  6. Geologie der terrestrischen Planeten und Monde.

    Science.gov (United States)

    Stöffler, D.

    Contents: 1. Inhalt und Aufgabe der Planetologie. 2. Aufbau des Sonnensystems. 3. Methoden der Exploration und Analyse der Planeten und Monde. 4. Geologische Grundprozesse auf den terrestrischen Planeten und Monden. 5. Geologische Formationen der planetaren Oberflächen. 6. Gesteine und Mineralien der planetaren Krusten. 7. Der innere Aufbau der terrestrischen planetaren Körper. 8. Vergleichende geologische Entwicklungsgeschichte der terrestrischen Planeten und des Mondes. 9. Ursprung und Entstehung der terrestrischen planetaren Körper.

  7. Risiko Video- und Computerspiele? Eine Studie über Video- und Computerspielnutzung und Aggression bei 12- und 16- jährigen Jugendlichen

    OpenAIRE

    Schiller, Eva-Maria; Strohmeier, Dagmar; Spiel, Christiane

    2009-01-01

    Video -und Computerspielen ist heutzutage eine beliebte Freizeitaktivität von Kindern und Jugendlichen, besonders von Jungen. Trotz der großen Vielfalt der angebotenen Video- und Computerspiele für Kinder und Jugendliche, konzentriert sich die Forschung vorwiegend auf negative Einflüsse von gewalthaltigen Video- und Computerspielen. Da nicht alle Kinder und Jugendliche ausschließlich gewalthaltige Video- und Computerspiele spielen, betrachten wir diesen Fokus in der Wissenschaft als zu eng ge...

  8. Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue of AML1-Deficient Embryonic Stem Cells by Using a Knock-in Strategy

    OpenAIRE

    Okuda, Tsukasa; Takeda, Kiyoshi; Fujita, Yasuko; Nishimura, Motohiro; Yagyu, Shigeki; Yoshida, Makie; Akira, Shizuo; Downing, James R.; Abe, Tatsuo

    2000-01-01

    AML1 is one of the most frequently mutated genes associated with human acute leukemia and encodes the DNA-binding subunit of the heterodimering transcriptional factor complex, core-binding factor (CBF) (or polyoma enhancer binding protein 2 [PEBP2]). A null mutation in either AML1 or its dimerizing partner, CBFβ, results in embryonic lethality secondary to a complete block in fetal liver hematopoiesis, indicating an essential role of this transcription complex in the development of definitive...

  9. Multiple tests for wind turbine fault detection and score fusion using two- level multidimensional scaling (MDS)

    Science.gov (United States)

    Ye, Xiang; Gao, Weihua; Yan, Yanjun; Osadciw, Lisa A.

    2010-04-01

    Wind is an important renewable energy source. The energy and economic return from building wind farms justify the expensive investments in doing so. However, without an effective monitoring system, underperforming or faulty turbines will cause a huge loss in revenue. Early detection of such failures help prevent these undesired working conditions. We develop three tests on power curve, rotor speed curve, pitch angle curve of individual turbine. In each test, multiple states are defined to distinguish different working conditions, including complete shut-downs, under-performing states, abnormally frequent default states, as well as normal working states. These three tests are combined to reach a final conclusion, which is more effective than any single test. Through extensive data mining of historical data and verification from farm operators, some state combinations are discovered to be strong indicators of spindle failures, lightning strikes, anemometer faults, etc, for fault detection. In each individual test, and in the score fusion of these tests, we apply multidimensional scaling (MDS) to reduce the high dimensional feature space into a 3-dimensional visualization, from which it is easier to discover turbine working information. This approach gains a qualitative understanding of turbine performance status to detect faults, and also provides explanations on what has happened for detailed diagnostics. The state-of-the-art SCADA (Supervisory Control And Data Acquisition) system in industry can only answer the question whether there are abnormal working states, and our evaluation of multiple states in multiple tests is also promising for diagnostics. In the future, these tests can be readily incorporated in a Bayesian network for intelligent analysis and decision support.

  10. Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission.

    Science.gov (United States)

    Sandonà, Dorianna; Desaphy, Jean-Francois; Camerino, Giulia M; Bianchini, Elisa; Ciciliot, Stefano; Danieli-Betto, Daniela; Dobrowolny, Gabriella; Furlan, Sandra; Germinario, Elena; Goto, Katsumasa; Gutsmann, Martina; Kawano, Fuminori; Nakai, Naoya; Ohira, Takashi; Ohno, Yoshitaka; Picard, Anne; Salanova, Michele; Schiffl, Gudrun; Blottner, Dieter; Musarò, Antonio; Ohira, Yoshinobu; Betto, Romeo; Conte, Diana; Schiaffino, Stefano

    2012-01-01

    The effect of microgravity on skeletal muscles has so far been examined in rat and mice only after short-term (5-20 day) spaceflights. The mice drawer system (MDS) program, sponsored by Italian Space Agency, for the first time aimed to investigate the consequences of long-term (91 days) exposure to microgravity in mice within the International Space Station. Muscle atrophy was present indistinctly in all fiber types of the slow-twitch soleus muscle, but was only slightly greater than that observed after 20 days of spaceflight. Myosin heavy chain analysis indicated a concomitant slow-to-fast transition of soleus. In addition, spaceflight induced translocation of sarcolemmal nitric oxide synthase-1 (NOS1) into the cytosol in soleus but not in the fast-twitch extensor digitorum longus (EDL) muscle. Most of the sarcolemmal ion channel subunits were up-regulated, more in soleus than EDL, whereas Ca(2+)-activated K(+) channels were down-regulated, consistent with the phenotype transition. Gene expression of the atrophy-related ubiquitin-ligases was up-regulated in both spaceflown soleus and EDL muscles, whereas autophagy genes were in the control range. Muscle-specific IGF-1 and interleukin-6 were down-regulated in soleus but up-regulated in EDL. Also, various stress-related genes were up-regulated in spaceflown EDL, not in soleus. Altogether, these results suggest that EDL muscle may resist to microgravity-induced atrophy by activating compensatory and protective pathways. Our study shows the extended sensitivity of antigravity soleus muscle after prolonged exposition to microgravity, suggests possible mechanisms accounting for the resistance of EDL, and individuates some molecular targets for the development of countermeasures. PMID:22470446

  11. Verbindung und Zugehörigkeit aus sozialpsychologischer und arbeitswissenschaftlicher Sicht

    OpenAIRE

    Tietel, Erhard

    2012-01-01

    Der Vortrag geht der Frage nach, wie sich Bindung und Zugehörigkeit in Organisationen gegenwärtig wandeln und gibt einen Überblick über psychologische und arbeitswissenschaftliche Theorien und Studien zu diesem Thema.

  12. Wasserkraftanlagen Planung, Bau und Betrieb

    CERN Document Server

    Giesecke, Jürgen

    2005-01-01

    Dieses Standardwerk der Wasserkraft liegt hiermit bereits in 4. Auflage vor. Es wurde noch stärker an die Erfordernisse der Praxis angepasst, komplett überarbeitet, aktualisiert und - wo es angebracht war - ergänzt. Wasserkraftanlagen bedeuten Planung, Gestaltung, Ausführung und Betrieb von Bauwerken sowie hydraulischen und elektrischen Komponenten.

  13. Der Geist und sein Gehirn

    OpenAIRE

    Elbert, Thomas

    2005-01-01

    Die Psychologie ist d i e Wissenschaft des Geistes - und muss daher die Untersuchung des Gehirns als Organ des Geistes strukturieren und leiten. Viele faszinierende Eigenschaften unserers mentalen Daseins wie Vorstellung, Intention oder Bewusstsein bleiben dem Zugang versperrt, wenn wir nur Verhalten und Erleben messen. Hier braucht die Psychologie die besten Methoden der Hirnforschung.

  14. Demokratie und Dekolonisierung in Bolivien

    OpenAIRE

    Ernst, Tanja

    2014-01-01

    Ausgehend von den fortdauernden Ausschlüssen und strukturellen Benachteiligungen der indigenen Bevölkerung Lateinamerikas kritisiert die vorliegende Arbeit die begrenzten Möglichkeiten gesellschaftlicher Teilhabe innerhalb von liberalen Wahldemokratien. Neben materiellen Ungleichheiten stehen immaterielle Formen der Ungleichheit, wie kulturelle und symbolische Barrieren politischer sowie sozialer Teilhabe im Fokus der Analyse. Das Forschungs- und Erkenntnisinteresse zielt darauf, Demokratie n...

  15. Clinical importance of CD7 expression in acute myelocytic leukemia (AML

    Directory of Open Access Journals (Sweden)

    Toogheh G

    2001-09-01

    Full Text Available Many studies have shown the clinical importance of CD7 expression in AML patients. To evaluate the clinical importance and response to chemotherapy in CD7 positive AML, this study was conducted. From the patients, 76 cases were studied during 3 years. In 3 years of this study 70.5 percent of CD7 positive and 89.6 percent of CD7 negative patients achieved complete remission with no significant difference between these two groups (P=0.11. We concluded that despite no importance of expression of this antigen in our patients, prevalence of CD7 positive cases in our study in higher than similar studies done abroad (52.6 percent versus 30 percent. It seems in respect of small number of our patients for evaluation of clinical and laboratory properties, larger study is needed.

  16. 急性髓细胞白血病(AML)的免疫治疗

    Institute of Scientific and Technical Information of China (English)

    胡炯

    2008-01-01

    @@ 急性髓细胞白血病(Actlte myeloid leukaemia,AML)是成人较常见白血病类型,现代诱导化疗治疗的完全缓解率达到65%~70%以上,以大剂量阿糖胞苷(cytarabine)为代表的强烈化疗巩固可进一步降低白血病细胞负荷,但仍无法彻底清除微小残留病变(MRD),除个别类型白血病如急性早幼粒细胞白血病(APL)以外,AML1-ETO阳性AML等多数疾病存在复发可能.

  17. Two methods for the quantitative analysis of surface antigen expression in acute myeloid leukemia (AML.

    Directory of Open Access Journals (Sweden)

    Jolanta Woźniak

    2004-10-01

    Full Text Available The expression of lineage molecules (CD13 and CD33, c-Kit receptor (CD117, CD34, HLA-DR and adhesion molecule CD49d was assessed in acute myeloid leukemia (AML blast cells from 32 cases, using direct and indirect quantitative cytometric analysis. High correlation (r=0.8 was found between antigen expression intensity values calculated by direct analysis method (ABC and by indirect analysis method (RFI. Moreover, the differences in expression intensity of CD13, CD117 and CD34 antigens were found between leukemic and normal myeloblasts. This may be helpful in identification of leukemic cells in the diagnostics of minimal residual disease after treatment in AML patients.

  18. Hormonersatztherapie - Nutzen und Risiken

    Directory of Open Access Journals (Sweden)

    Rabe T

    2006-01-01

    Full Text Available In der Women’s Health Initiative (WHI wurden für die Hormonersatztherapie mit Estrogen-Gestagen sowie mit Estrogen erhöhte Risiken für Hirninsult und Venenthrombosen beobachtet. Speziell für die kombinierte Therapie zeigte sich ab dem fünften Behandlungsjahr ein erhöhtes Brustkrebsdiagnoserisiko und bei Behandlungsbeginn mehr als 20 Jahre nach der Menopause auch ein erhöhtes Risiko für Herzinfarkte. Diese Risiken sollten beachtet, aber stets dem individuell erreichbaren Nutzen entgegengesetzt werden. Dieser wurde in der WHI bestätigt, besonders aber auch in einer Vielzahl von Studien, wie etwa der Nurses Health Study, welche den praktischen Verhältnissen hinsichtlich Auswahl der Frauen und zeitlicher Beginn der Hormonbehandlung besser als die WHI entsprechen. Die Wirksamkeit ist für die klassischen Indikationen wie vaso-vegetative und urogenitale Beschwerden nie angezweifelt worden. Auch die Primärprävention einer Osteoporose ist gesichert. Darüber hinaus kann auch die Primärprävention von kolorektalen Karzinomen sowie für die Estrogenmonotherapie auch für Herzinfarkte als nahezu gesichert angesehen werden. Bei individualisierter, niedrig dosierter und kontrollierter Anwendung der Hormonersatztherapie ist davon auszugehen, daß der Nutzen gegenüber den Risiken überwiegt, insbesondere bei frühem Behandlungsbeginn, im Alter von unter 60 Jahren, möglichst bereits in der Peri- und frühen Postmenopause. Besonders hoch ist der Nutzen für die Estrogentherapie ohne Gestagenzusatz. So zeigte sich in der WHI für Frauen unter 60 Jahren nur das bekannte Risiko für Venenthrombosen. Die Risiken für Osteoporose, kolorektale Karzinome, Herzinfarkte und selbst Brustkrebs waren in dieser Altersklasse um 20–40 % reduziert.

  19. Molecular cytogenetic findings in a three-way novel variant of t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in AML-M2.

    Science.gov (United States)

    Ahmad, Firoz; Kokate, Prajakta; Chheda, Pratiksha; Dalvi, Rupa; Das, Bibhu Ranjan; Mandava, Swarna

    2008-01-15

    Acute myeloid leukemia (AML) is a malignant neoplasm of hematopoietic stem cells characterized by an abnormal proliferation of myeloid precursors, a reduced rate of apoptosis, and an arrest in cellular differentiation. The present report deals with the results of hematologic, immunophenotypic, cytogenetic, fluorescence in situ hybridization (FISH), and molecular analyses of a 53-year-old female patient diagnosed with AML-M2. Cytogenetic and FISH analysis revealed a complex translocation involving three chromosomes showing t(1;8;21)(p35;q22;q22). The observation of breakpoints at 8q22 and 21q22 suggests a rearrangement of the ETO and AML1 genes, respectively. Using a dual-color FISH test with ETO and AML1 probes, an AML1/ETO fusion signal on the derivative 1p35 instead of der(8) was demonstrated. To the best of our knowledge, this is the first report about the relocation of the AML1/ETO fusion gene to the 1p35 rather than der(8), suggesting the presence of a novel variant of t(8;21)(q22;q22) in the observed patient. PMID:18206543

  20. Raumontologie und Raumfahrt um 1600 und 1900

    OpenAIRE

    Heuser, Marie-Luise

    2016-01-01

    Ausgangsthese des Beitrages ist, dass die technische Raumfahrt das Produkt eines langen kulturellen Prozesses ist. Wesentliche Marksteine waren hierbei die Entwicklung von neuen Raumkonzepten in der Renaissance und die virtuellen Raumfahrten in Giordano Brunos Philosophie, der bald schon literarische Fahrten zum Mond folgten. Der Raum als unbegrenzte Entität sprengte die an einer gegenständlichen Repräsentation orientierte Dingontologie. Der leere Raum wurde nun nicht mehr als ein Körper begr...

  1. Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

    DEFF Research Database (Denmark)

    Rapin, Nicolas; Bagger, Frederik Otzen; Jendholm, Johan;

    2014-01-01

    Gene expression profiling has been used extensively to characterize cancer, identify novel subtypes, and improve patient stratification. However, it has largely failed to identify transcriptional programs that differ between cancer and corresponding normal cells and has not been efficient in...... hematopoietic hierarchy, using expression profiles from normal stem/progenitor cells, and next mapped the AML patient samples to this landscape. This allowed us to identify the closest normal counterpart of individual AML samples and determine gene expression changes between cancer and normal. We find the...... cancer vs normal method (CvN method) to be superior to conventional methods in stratifying AML patients with aberrant karyotype and in identifying common aberrant transcriptional programs with potential importance for AML etiology. Moreover, the CvN method uncovered a novel poor-outcome subtype of normal...

  2. In vitro und in vivo Untersuchungen zu Terpenbiosynthesen und Stoffwechselnetzwerken

    OpenAIRE

    Adam, Petra

    2007-01-01

    Die IspG und IspH Proteine katalysieren die letzten Schritte der Mevalonat-unabhängigen Biosynthese der Terpenbausteine Isopentenyldiphosphat und Dimethylallyldiphosphat. Durch Isotopmarkierung an rekombinanten Bakterien und Enzymen wurde gezeigt, dass IspG die NADH- und Co(II)-abhängige Bildung des Intermediats 2C-Methyl-D-erythritol-2,4-cyclodiphosphat zu 1-Hydroxy-2-methyl-2(E)-butenyl-4-diphosphat katalysiert. IspH katalysiert die NADH-, FAD- und Co(II)-abhängige Weiterreaktion zu Isopent...

  3. Improving auditor effectiveness in assessing KYC/AML practices: Case study in a Luxembourgish context

    OpenAIRE

    Dieter De Smet; Anne-Laure Mention

    2011-01-01

    Purpose – The purpose of this paper is to report on the suitability of an ISO standard to create an internal control assessment model, which effectively acts as a control system template and mental model to evaluate compliance with the Know Your Customer (KYC) and anti-money laundering (AML) requirements in the Luxembourg retail and private banking sector. Design/methodology/approach – This paper used a qualitative approach with various focus groups and case studies, to elaborate and validate...

  4. Lifelong persistence of AML associated MLL partial tandem duplications (MLL-PTD) in healthy adults.

    OpenAIRE

    Basecke, Jorg; Podleschny, Martina; Clemens, Robert; Schnittger, Susanne; Viereck, Volker; Trumper, Lorenz; Griesinger, Frank

    2006-01-01

    KEYWORDS CLASSIFICATION: Adult;Antigens,CD;blood;B-Lymphocytes;Female;Fetal Blood;genetics;Gene Duplication;Germany;Hematopoietic Stem Cells;Humans;Infant,Newborn;Leukemia;Leukemia,Myelocytic,Acute;Lymphoma,Mixed-Cell;metabolism;Male;mechanisms of carcinogenesis;Myeloid-Lymphoid Leukemia Protein;pathology;Research;T-Lymphocytes. AML-associated MLL-PTD contribute to leukemogenesis by a gain of function and confer an unfavorable prognosis. Like other leukemia associated aberrations they are ...

  5. Bewußtseins- und Organisationsentwicklung - Rationale und nichtrationale Grundlagen, Konzepte und Realitäten

    OpenAIRE

    Epstein, Holger

    2008-01-01

    Die aktuellen Krisen der menschlichen Lebenswelten und von Mutter Erde zeigen die Dringlichkeit eines grundlegenden Wandels der Art, wie wir über Wirtschaft, Organisationen und Wissenschaft denken und wie wir mit diesem Denken unser Handeln gestalten. Die wissenschaftlichen und organisationalen Revolutionen, an deren Wiege herausragende Persönlichkeiten wie Newton, Descartes, Kopernikus, Adam Smith, Calvin, Frederick W. Taylor ... stehen, bilden nun aus ihrem Schatten heraus zunehmend existen...

  6. Verstaatlichungs- und Entstaatlichungsprozesse von Polizei und Rechtssystem und ihre Auswirkungen auf die Todesstrafe

    OpenAIRE

    Reicher, Dieter

    2003-01-01

    'In diesem Aufsatz wird analysiert, welche Auswirkungen Ver- und Entstaatlichungsprozesse von Polizei und Rechtssystem auf die Anwendung der Todesstrafe haben. Ich werde argumentieren, dass stark bürokratisierte Staaten unter bestimmten Umständen dazu neigen, weniger grausame Strafen zu verhängen als plutokratische Staaten mit einer dünnen Verwaltungsstruktur. Das ist deshalb so, weil bürokratisch betriebene Gerichtsbarkeit und Polizei ein stark distanziertes Verhältnis zu Tätern und Opfern v...

  7. The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling

    OpenAIRE

    Valdez, Benigno C.; Li, Yang; Murray, David; Champlin, Richard E.; Andersson, Borje S.

    2010-01-01

    DNA alkylating agents alone or with ionizing radiation have been the preferred conditioning treatment in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In search of less toxic alternatives, we hypothesized that combination of busulfan (Bu), fludarabine (Flu) and clofarabine (Clo) would provide superior efficacy. At low concentrations, these drugs show synergistic cytotoxicity in Bu-resistant AML KBM3/Bu2506 cells. Similar molecular responses were observed in other AML cell li...

  8. The Hematopoietic Transcription Factor AML1 (RUNX1) Is Negatively Regulated by the Cell Cycle Protein Cyclin D3

    OpenAIRE

    Peterson, Luke F.; Boyapati, Anita; Ranganathan, Velvizhi; Iwama, Atsushi; Tenen, Daniel G.; Tsai, Schickwann; Zhang, Dong-Er

    2005-01-01

    The family of cyclin D proteins plays a crucial role in the early events of the mammalian cell cycle. Recent studies have revealed the involvement of AML1 transactivation activity in promoting cell cycle progression through the induction of cyclin D proteins. This information in combination with our previous observation that a region in AML1 between amino acids 213 and 289 is important for its function led us to investigate prospective proteins associating with this region. We identified cycl...

  9. Investigating possible bypass mechanisms to sensitize AML blasts for combination therapy: Targeting ligand induced receptor tyrosine kinase signaling

    OpenAIRE

    Kampen, Kim Rosalie

    2015-01-01

    Leukemia is the most common form of pediatric cancer and the acute myeloid variant still confers the poorest outcome. Therefore, we attempted to contribute to the understanding of cellular mechanisms and the proteins involved that contribute to acute myeloid leukemia (AML) growth, differentiation blockade, and cellular resistance in AML and their adaptation opportunities for therapeutic intervention. We investigated how we can identify cellular resistance and develop combination therapies tha...

  10. AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model.

    Science.gov (United States)

    Wunderlich, Mark; Mizukawa, Benjamin; Chou, Fu-Sheng; Sexton, Christina; Shrestha, Mahesh; Saunthararajah, Yogen; Mulloy, James C

    2013-03-21

    As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to combined Ara-C (cytarabine) and doxorubicin treatment. We observed significant toxicity associated with doxorubicin that required optimization of the route of injection as well as the maximum-tolerated dose for immunodeficient strains. Mice treated with an optimized 5-day induction protocol showed transient weight loss, short-term reduction of peripheral blood cell and platelet counts, and slight anemia. Considerable cytotoxicity was observed in the bone marrow (BM), with primitive LSK cells having a significant survival advantage relative to more mature cells, consistent with the idea of chemotherapy targeting actively growing cells. Treated leukemic mice demonstrated reduced disease burden and increased survival, demonstrating efficacy. AML cells showed significantly increased sensitivity to doxorubicin-containing therapy compared with murine BM cells. Although early treatment could result in some cures, mice with significant leukemia grafts were not cured by using induction therapy alone. Overall, the data show that this model system is useful for the evaluation of novel chemotherapies in combination with standard induction therapy. PMID:23349390

  11. Is it important to decipher the heterogeneity of "normal karyotype AML"?

    Science.gov (United States)

    Nimer, Stephen D

    2008-03-01

    Almost half of adult acute myelogenous leukemia (AML) is normal cytogenetically, and this subgroup shows a remarkable heterogeneity of genetic mutations at the molecular level and an intermediate response to therapy. The finding of recurrent cytogenetic abnormalities has influenced, in a primary way, the understanding and treatment of leukemias. Yet "normal karyotype AML" lacks such obvious abnormalities, but has a variety of prognostically important genetic abnormalities. Thus, the presence of a FLT3-ITD (internal tandem duplication), MLL-PTD (partial tandem duplication), or the increased expression of ERG or EVI1 mRNAs confer a poor prognosis, and an increased risk of relapse. In contrast, the presence of cytoplasmic nucleophosmin or C/EBPA mutations is associated with lower relapse rates and improved survival. Although resistance to treatment is associated with specific mutations, the degree to which the leukemia resembles a stem cell in its functional properties may provide greater protection from the effects of treatment. Although usually all of the circulating leukemia cells are cleared following treatment, a small residual population of leukemic cells in the bone marrow persists, making this disease hard to eradicate. Increased understanding of the biological consequences of at least some of these mutations in "normal karyotype AML" is leading to more targeted approaches to develop more effective treatments for this disease. PMID:18342811

  12. Problems getting from the laboratory to the field: Reclamation of an AML site

    International Nuclear Information System (INIS)

    Acid and toxic abandoned mineland sites provide an opportunity whereby flue gas desulfurization (FGD) by-product can be beneficially used as a reclamation amendment material. Studies are needed to compare the effectiveness of FGD by-product, as compared with resoil, for reclamation purposes. Initial studies provided information about the chemical and physical properties of the FGD by-product and how to transport and blend the FGD by-product with yard waste compost. Greenhouse studies indicated that rates of 125 dry tons/acre of FGD and 50 dry tons/acre of yard waste compost would provide optimum results for reclamation of acid and toxic spoil contained at the Fleming abandoned mineland (AML) site. Their results showed that heavy metal loading rates were much lower using the FGD/compost mixture than using resoil material. Dioxin in the mixture was also less than the 5 ppt level considered as normal background. The technical problems of using FGD by-product for reclamation of an AML site were solved. However, considerable efforts to educate the public about the merits of reclaiming the Fleming AML site using this FGD/compost mixture were required before initiating field reclamation activities. Education efforts must continue if FGD by-products are to achieve general acceptance as a reclamation alternative to resoil in cases where resoil is of scarce supply

  13. Effects of T-Cell Depletion on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in AML Patients

    Directory of Open Access Journals (Sweden)

    Gabriela Soriano Hobbs

    2015-03-01

    Full Text Available Graft versus host disease (GVHD remains one of the leading causes of morbidity and mortality associated with conventional allogeneic hematopoietic stem cell transplantation (HCT. The use of T-cell depletion significantly reduces this complication. Recent prospective and retrospective data suggest that, in patients with AML in first complete remission, CD34+ selected grafts afford overall and relapse-free survival comparable to those observed in recipients of conventional grafts, while significantly decreasing GVHD. In addition, CD34+ selected grafts allow older patients, and those with medical comorbidities or with only HLA-mismatched donors to successfully undergo transplantation. Prospective data are needed to further define which groups of patients with AML are most likely to benefit from CD34+ selected grafts. Here we review the history of T-cell depletion in AML, and techniques used. We then summarize the contemporary literature using CD34+ selection in recipients of matched or partially mismatched donors (7/8 or 8/8 HLA-matched, and provide a summary of the risks and benefits of using T-cell depletion.

  14. Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation.

    Science.gov (United States)

    Link, Kevin A; Lin, Shan; Shrestha, Mahesh; Bowman, Melissa; Wunderlich, Mark; Bloomfield, Clara D; Huang, Gang; Mulloy, James C

    2016-08-01

    Chromosomal translocation 8;21 is found in 40% of the FAB M2 subtype of acute myeloid leukemia (AML). The resultant in-frame fusion protein AML1-ETO (AE) acts as an initiating oncogene for leukemia development. AE immortalizes human CD34(+) cord blood cells in long-term culture. We assessed the transforming properties of the alternatively spliced AE isoform AE9a (or alternative splicing at exon 9), which is fully transforming in a murine retroviral model, in human cord blood cells. Full activity was realized only upon increased fusion protein expression. This effect was recapitulated in the AE9a murine AML model. Cotransduction of AE and AE9a resulted in a strong selective pressure for AE-expressing cells. In the context of AE, AE9a did not show selection for increased expression, affirming observations of human t(8;21) patient samples where full-length AE is the dominant protein detected. Mechanistically, AE9a showed defective transcriptional regulation of AE target genes that was partially corrected at high expression. Together, these results bring an additional perspective to our understanding of AE function and highlight the contribution of oncogene expression level in t(8;21) experimental models. PMID:27457952

  15. Konservative und operative Therapie bei Harninkontinenz, Deszensus und Urogenitalbschwerden

    Directory of Open Access Journals (Sweden)

    Eberhard J

    2000-01-01

    Full Text Available Urogynäkologische Beschwerden wie Harninkontinenz, Infektionen, vulvo-vaginale und vesikale Reizzustände, Juckreiz, Dyspareunie, Beckenbodenschwäche, Deszensusbeschwerden werden in irgendeiner Form bei fast jeder Frau im Laufe ihres Lebens zur behandlungsbedürftigen Krankheit. Die Ursachen dieser häufigsten Frauenleiden sind vielfältig. Eine erfolgreiche Therapie sollte auf der Polyätiologie urogynäkologischer Krankheiten aufbauen und die verschiedenen Therapiemöglichkeiten zu einem patienten- und krankheitsadaptierten Behandlungskonzept zusammenfügen. Die Bausteine der konservativen Therapie sind: Trink- und Miktionstraining, Physiotherapie mit den Hilfsmitteln Kugeln, Kegel, Elektrostimulation und Biofeedbackmethoden; Östrogene, Pessare, Infekttherapie, Intimpflege, blasenrelaxierende und andere urogynäkologische Medikamente. Der Einsatz dieser Therapiebausteine wird ausführlich besprochen. Auch wird gezeigt, wann und wie operiert werden soll, wenn die konservative Therapie nicht zum Ziel führt.

  16. Synthese und Charakterisierung von Eisen-, Cobalt- und Galliumkomplexen mit den redoxaktiven Amidligandsystemen Pyridincarboxamidobenzol und Hydroxyphenyloxamid

    OpenAIRE

    Beckmann, Udo

    2001-01-01

    Liganden vom Typ Pyridincarboxamidobenzol sowie Hydroxyphenyloxamid sind in komplexierter Form redoxaktive Verbindungen. Elektrochemische Untersuchungen ihrer ein- und zweikernigen Eisen-, Cobalt- und Galliumkomplexe zeigen, daß sie in der Lage sind, reversibel Elektronen aufzunehmen bzw. abzugeben. Die Oxidations- bzw. Reduktionsprodukte wurden coulometrisch erzeugt. Die Entscheidung einer ligandzentrierten oder metallzentrierten Reaktion wurde dabei mittels EPR- und Mößbauerspek...

  17. Supraleitung Grundlagen und Anwendungen

    CERN Document Server

    Buckel, Werner

    2013-01-01

    Grundlegende Konzepte und Eigenschaften von Supraleitern, die Herstellung und Entwicklung von neuen supraleitenden Materialien sowie moderne Anwendungsbereiche sind die Schwerpunktthemen des Buches. Das größte Potential zur Nutzung der Supraleitung liegt in der Energietechnik. Fast unbemerkt trägt die Einführung von Kabeln, Magneten, Transformatoren oder Lagern aus supraleitenden Materialien bei zur Effizienzsteigerung bei der Stromübertragung oder in Motoren. Durch seiner klare Sprache und zahlreiche erläuternde Abbildungen eignet sich der Band hervorragend als einführendes Lehrbuch. Der Schwierigkeitsgrad wird von Kapitel zu Kapitel gesteigert. So können auch Einsteiger ohne einschlägige Vorkenntnisse dem Stoff folgen. Dank der über 350 Literaturhinweise bekommt der Leser außerdem einen Überblick über die wichtigsten Publikationen zum Thema. Ein unverzichtbares Lehrbuch also für Physik-Studenten und Studierende der Ingenieurwissenschaften. Fachleuten in Forschung und Praxis leistet das Buch au...

  18. Technikwissenschaft - Erfinden und Entdecken

    Science.gov (United States)

    Linnemann, Gerhard

    Umrissen wird das allgemeine Ziel der Technikwissenschaft, konstruktiv zu verwerten und nicht-natürlich Entdeckbares zu erfinden. Wir befinden uns in einer Umwälzung der Technik im Verlauf der wissenschaftlich-technischen Revolution, auf dem Wege zu einem neuen Techniktyp. Dieser schafft und nutzt die künstliche Intelligenz. Dazu benötigt der in der Technik tätige Mensch spezielle Kenntnisse und Erfahrungen in kreativ-konstruktiver, -gestalterischer und erfinderischer Sicht mit dem Einsatz spezieller Strukturen und Sprachen. Vorschläge zur Arbeitsweise in der Technik werden gegeben.Translated AbstractTechnological Science-Invent and DiscoverThe general aim of engineering science is outlined to utilize results constructively and to invent something that cannot be discovered in nature. We are now in a period of transformation of technology in the course of scientific-technological revolution, on the way to a new type of technology. This new type creates and utilizes artificial intelligence. For this, man acitive in this field requires special knowledge and experiences in a creative, constructive, design-oriented and ultimately inventive way by deploying special structures and languages. There are also made some proposals concerning the method of working in the field of technology.

  19. Patentierung und Patentlage

    Science.gov (United States)

    Herrmann, Uwe

    Gewerbliche Schutzrechte nehmen in der nationalen Rechts- und Wirtschaftsordnung sowie auch auf internationaler Ebene stetig an Bedeutung zu. Sie dienen dem Schutz geistigen Eigentums und sind für jeden Gewerbetreibenden nicht nur im Hinblick darauf von Bedeutung, eigene Rechte zu sichern, sondern auch insofern von Relevanz, dass ein Verstoß gegen Rechte Dritter zu vermeiden ist. Zu den gewerblichen Schutzrechten gehören unter anderem Kennzeichenrechte, Geschmacksmusterrechte sowie die sogenannten technischen Schutzrechte in Form des Patents sowie des Gebrauchsmusters. Die folgenden Ausführungen befassen sich ausschließlich mit den technischen Schutzrechten und geben eine kurze Einführung in die Voraussetzungen, das Entstehen und den Wegfall sowie in die Wirkungen technischer Schutzrechte. Beleuchtet wird die Situation im Wesentlichen im Hinblick auf nationale technische Schutzrechte, d. h. auf Deutsche Patente und Gebrauchsmuster sowie auf Europäische Patente, die Schutz in Deutschland entfalten. Die Möglichkeit der Erlangung von Schutzrechten im außereuropäischen Ausland wird nur am Rande gestreift.

  20. Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation.

    LENUS (Irish Health Repository)

    Rishi, Loveena

    2014-04-10

    The loss of regulation of cell proliferation is a key event in leukemic transformation, and the oncogene tribbles (Trib)2 is emerging as a pivotal target of transcription factors in acute leukemias. Deregulation of the transcription factor E2F1, normally repressed by CCAAT enhancer-binding protein α (C\\/EBPα)-p42, occurs in acute myeloid leukemia (AML), resulting in the perturbation of cell cycle and apoptosis, emphasizing its importance in the molecular pathogenesis of AML. Here we show that E2F family members directly regulate Trib2 in leukemic cells and identify a feedback regulatory loop for E2F1, C\\/EBPα, and Trib2 in AML cell proliferation and survival. Further analyses revealed that E2F1-mediated Trib2 expression was repressed by C\\/EBPα-p42, and in normal granulocyte\\/macrophage progenitor cells, we detect C\\/EBPα bound to the Trib2 promoter. Pharmacological inhibition of the cell cycle or Trib2 knockdown resulted in a block in AML cell proliferation. Our work proposes a novel paradigm whereby E2F1 plays a key role in the regulation of Trib2 expression important for AML cell proliferation control. Importantly, we identify the contribution of dysregulated C\\/EBPα and E2F1 to elevated Trib2 expression and leukemic cell survival, which likely contributes to the initiation and maintenance of AML and may have significant implications for normal and malignant hematopoiesis.

  1. Zum Einfluss des Filtermittels und der auftretenden Interferenzen zwischen Filterkuchen und Filtermittel bei der Kuchenfiltration

    OpenAIRE

    Tichy, Josef W.

    2007-01-01

    Die Bestimmung der Filtrierbarkeit von Suspensionen mit einer neuen Auswertemethode auf der Grundlage bekannter und erprobter Auswerteverfahren ergibt eindeutige Auswertekriterien insbesondere bei inkompressiblen Feststoffen und newtonschen Flüssigkeiten. Eine verbesserte Messtechnik erfasst den Filtratanfall bei beginnender Sättigung genau und vereinfacht die Zeitnahme. Methode und Technik erhöhen Genauigkeit und Reproduzierbarkeit bei der Bestimmung von Filtermittel- und Filterkuchenwiderst...

  2. Campusnetz-Management - Stand und Ausblick

    OpenAIRE

    Schier, Thomas

    2002-01-01

    Gemeinsamer Workshop von Universitaetsrechenzentrum und Professur Rechnernetze und verteilte Systeme der Fakultaet fuer Informatik der TU Chemnitz. Der Vortrag stellt die aktuellen Technologien und Komponenten des Netzwerkmanagements an der TU Chemnitz vor. Insbesondere werden dabei die OSI-Schichten 1, 2 und 3 behandelt. Ansätze für die Vervollständigung und Weiterentwicklung werden skizziert.

  3. Venture Kapital und Life Science

    Science.gov (United States)

    Moss, Sebastian; Beermann, Christian

    Um sich weiter im internationalen Wettbewerb behaupten zu können, müssen deutsche Unternehmen heute in Schlüsseltechnologien wie die Medizintechnik und die Biotechnologie, zusammenfassend unter dem Begriff der Life Sciences bekannt, investieren. Eine führende Wettbewerbsposition erfordert immer die konsequente Weiterentwicklung von Produkten und Lösungen, um Innovationspotenziale in medizinische Verfahren umzusetzen. Die damit unmittelbar verbundenen hohen Ausgaben für Forschung und Entwicklung stellen ein bedeutendes Problem junger Life Science Unternehmen dar. Vor allem die, verglichen mit nicht-medizinischen Branchen, längeren Forschungs- und Entwicklungszyklen in der Frühphase eines Life Science Unternehmens und die längere Dauer bis zur Profitabilität erhöhen das Risiko der Finanzinvestoren. Die Zeitdauer, um ein medizinisches Produkt bis zur Marktreife zu entwickeln und letztlich auf dem Markt anzubieten, kann aufgrund der notwendigen intensiven Forschung nur unscharf geplant werden und erhöht die Unsicherheit über den Zeitpunkt der ersten Einnahmen. Damit verschärfen sich gerade im Life Science Bereich allgemeine Problematiken von Gründungs- und Wachstumsfinanzierungen wie starke Informationsasymmetrien zwischen Gründer und potentiellen Kapitalgebern. Oftmals ist die Entwicklung einer innovativen Technologie abhängig von einzelnen Personen, von deren Wissen und Engagement die Umsetzung und der Erfolg eines gesamten Produktkonzeptes abhängen.

  4. Der Nahostkonflikt und die Medien

    Directory of Open Access Journals (Sweden)

    Carola Richter

    2014-06-01

    Full Text Available Diese Einführung in eine Themenausgabe zu den vielfältigen Rollen der Medien im Nahostkonflikt skizziert die Probleme, die sich für Medien und Journalisten als Akteure im Konflikt, Adressaten der Konfliktparteien und Anlass für Konflikt durch ihre Berichterstattung ergeben. Das Konfliktgebiet Israel und Palästina ist sowohl für Forschung über Auslandsbericht-erstattung, über transnationale Agenda Building- und Public Diplomacy-Prozesse als auch über mediensystemische Entwicklungen in Besatzer- und Besatzungsgebieten interessant. Der Artikel gibt einen Überblick über das Feld und führt dabei in die in der Themenausgabe präsentierten empirischen Studien zum Nahostkonflikt und den Medien ein.

  5. Diabetische Makroangiopathie und Insulinresistenz

    Directory of Open Access Journals (Sweden)

    Kerner W

    2003-01-01

    Full Text Available Aus prospektiven Studien, in denen die Insulinresistenz direkt gemessen wurde, gibt es Hinweise, daß Insulinresistenz ein Prädiktor für die koronare Herzerkrankung ist. Die schädigende Wirkung der Insulinresistenz auf die Gefäße wird durch Hyperlipidämie, Hypertonie und Hyperkoagulabilität vermittelt. Hyperglykämie und Hyperinsulinismus dürften in diesem Zusammenhang von sekundärer Bedeutung sein. Eine wichtige, in den Einzelheiten aber noch unzureichend erforschte Rolle spielen sicherlich Endotheldysfunktion und entzündliche Vorgänge. Dies gilt vor allem im Hinblick auf zukünftige therapeutische Interventionen.

  6. Hormonersatztherapie - Nutzen und Risiken

    Directory of Open Access Journals (Sweden)

    Rabe T

    2004-01-01

    Full Text Available Zwei placebokontrollierte Interventionsstudien mit kombinierter Hormontherapie hatten die Diskussion ausgelöst, ob diese von Nutzen sei, da erhöhte Risiken für Brustkrebs, Herzinfarkte, Thrombosen und Hirninsult berechnet wurden. Bei vorbestehender Disposition müssen diese Risiken stets beachtet werden; insgesamt sind bei individueller Bilanzierung diese gegenüber dem erreichbaren Nutzen zu relativieren. Eine Prävention von kolorektalen Karzinomen scheint möglich, obwohl dieser präventive Ansatz derzeit keine Indikation für eine Hormonersatztherapie darstellt. Die Osteoporoseprävention wurde bestätigt, die klassischen Indikationen wie vasovegetative und urogenitale Beschwerden waren nie angezweifelt worden. Bei individualisierter, niedrig dosierter, indizierter und kontrollierter Anwendung der Hormonersatztherapie ist davon auszugehen, daß der Nutzen die Risiken überwiegt.

  7. Lipide und Diabetes

    Directory of Open Access Journals (Sweden)

    Georg P

    2000-01-01

    Full Text Available Atherosklerose ist eine der häufigsten Komplikationen bei Diabetes und verantwortlich für erhöhte Morbidität und Mortalität. Diabetische Dyslipidämie führt zu erhöhten Triglyzeridspiegeln und zu verringerten HDL-Cholesterinspiegeln. Die LDL-Cholesterin-Konzentration unterscheidet sich zwar quantitativ nicht signifikant zwischen Diabetikern und Nichtdiabetikern, allerdings zeigen Typ-2-Diabetiker typischerweise überwiegend kleine, dichte LDL-Partikel mit größerer Affinität für Oxidation. Epidemiologische Studien haben gezeigt, daß Patienten mit Diabetes mellitus Typ-2 ohne kardiovaskuläre Erkrankungen in der Anamnese dasselbe Risiko für kardiale Ereignisse wie Nichtdiabetiker mit vorbestehender Herzkrankheit haben. Die erhöhte Inzidenz kardialer Erkrankungen bei Diabetikern, die höhere Sterblichkeitsrate und die höhere 1-Jahres-Mortalität bei Patienten mit Myokardinfarkt weisen deutlich auf die Wichtigkeit einer lipidsenkenden Therapie hin. Leider fußen die Grundlagen der Prävention kardiovaskulärer Erkrankungen bei Diabetikern lediglich auf pathophysiologischen Untersuchungen, interventionellen Studien an Nichtdiabetikern und Post-hoc-Subgruppenanalysen bei Diabetikern. Daher sind noch viele Fragen betreffend die Therapie der diabetischen Dyslipidämie offen. Jedenfalls aber zeigen die Studien, daß Cholesterinsenkung bei Diabetes mellitus Typ-2-Patienten zumindest so effektiv wie bei Nichtdiabetikern ist. Resultate von prospektiven Lipidsenkungs-Studien bei Diabetikern werden daher mit großem Interesse erwartet.

  8. Die biene und ihre produkte in der kunst und im alltagsleben (Fruhchristliche und byzantinische Zeit

    Directory of Open Access Journals (Sweden)

    Liveri Angeliki

    2010-01-01

    Full Text Available Die vorliegende Arbeit ist in zwei Teile geteilt: den kunst- und kulturhistorischen Teil. Im ersten Teil werden Darstellungen uber Bienen Bienenzucht, Honig und Wachs seit der fruhchristlichen bis zur spatbyzantinischen Zeit vorgefuhrt. Daher ist es als Beitrag in der "Ikonographie" der Biene wahrend dieser Zeit zu verstehen. Im kulturhistorischen Teil werden Informationen uber die Bienenzucht, den Handel mit Honig und Wachs sowie ihre vielfaltige Anwendung von der byzantinischen Gesellschaft an Hand der primaren Quellen, des Standes der Forschung und der archaologischen Funden erwahnt. Damit ist erwunscht ein moglichst gutes Bild der byzantinischen Bienenzucht wieder zu geben und die Nutzung der Bienenprodukte in Byzanz anschaulich zu machen.

  9. Clofarabine in combination with a standard remission induction regimen (cytosine arabinoside and idarubicin) in patients with previously untreated intermediate and bad-risk acute myelogenous leukemia (AML) or high-risk myelodysplastic syndrome (HR-MDS): phase I results of an ongoing phase I/II study of the leukemia groups of EORTC and GIMEMA (EORTC GIMEMA 06061/AML-14A trial).

    Science.gov (United States)

    Willemze, R; Suciu, S; Muus, P; Halkes, C J M; Meloni, G; Meert, L; Karrasch, M; Rapion, J; Vignetti, M; Amadori, S; de Witte, T; Marie, J P

    2014-06-01

    This study aims to determine the maximum tolerated dose (MTD) of clofarabine combined with the EORTC-GIMEMA 3 + 10 induction regimen (idarubicin + cytosine arabinoside) in adults with untreated acute myelogenous leukemia or high-risk myelodysplastic syndrome. In this phase I trial, 25 patients (median age 56 years) received 5 days of clofarabine as 1-h infusion (arm A) or push injection (arm B) at the dose level of 5 × 10 or 5 × 15 mg/m(2)/day in an algorithmic dose escalation 3 + 3 design. A consolidation course (intermediate dose cytosine arabinoside, idarubicin) was planned for patients in complete remission (CR). Primary endpoint was safety and tolerance as measured by dose limiting toxicity (DLT); secondary endpoints were response rate, other grade III/IV toxicities, and hematological recovery after induction and consolidation. Five DLTs were observed (in arm A: one DLT at 10 mg/m(2)/day, three at 15 mg/m(2)/day; in arm B: one DLT at 15 mg/m(2)/day). Three patients receiving 15 mg/m(2)/day were withdrawn due to adverse events not classified as DLT. Prolonged hypoplasia was observed in five patients. CR + complete remission with incomplete recovery were achieved in 21 patients (11/12 (92 %) receiving clofarabine 10 mg/m(2)/day; 10/13 (77 %) receiving clofarabine 15 mg/m(2)/day). Clofarabine, 5 × 10 mg/m(2)/day, resulted in one DLT and no early treatment withdrawals. MTD of clofarabine combined with cytosine arabinoside and idarubicin is 5 × 10 mg/m(2)/day. PMID:24682421

  10. Clofarabine in combination with a standard remission induction regimen (cytosine arabinoside and idarubicin) in patients with previously untreated intermediate and bad-risk acute myelogenous leukemia (AML) or high-risk myelodysplastic syndrome (HR-MDS): phase I results of an ongoing phase I/II study of the leukemia groups of EORTC and GIMEMA (EORTC GIMEMA 06061/AML-14A trial)

    NARCIS (Netherlands)

    Willemze, R.; Suciu, S.; Muus, P.; Halkes, C.J.; Meloni, G.; Meert, L.; Karrasch, M.; Rapion, J.; Vignetti, M.; Amadori, S.; Witte, T.J.M. de; Marie, J.P.

    2014-01-01

    This study aims to determine the maximum tolerated dose (MTD) of clofarabine combined with the EORTC-GIMEMA 3 + 10 induction regimen (idarubicin + cytosine arabinoside) in adults with untreated acute myelogenous leukemia or high-risk myelodysplastic syndrome. In this phase I trial, 25 patients (medi

  11. Homocystein und Demenzerkrankungen

    OpenAIRE

    Kessler, Holger; Bleich, Stefan; Falkai, Peter; Supprian, Tillmann

    2003-01-01

    Homocystein stellt einen Risikofaktor für atherosklerotische Gefäßerkrankungen einschließlich zerebraler Makro- und Mikroangiopathie dar. Darüber hinaus wird auch ein Zusammenhang mit kognitiven Störungen einschließlich Alzheimer- und vaskulärer Demenz diskutiert. Eine Hyperhomocysteinämie könnte indirekter Marker eines einer kognitiven Störung zugrunde liegenden intrazellulären Vitaminmangels (Vitamin B12, Vitamin B6, Folsäure) sein, welcher aus einer verminderten Aufnahme oder aus einem ges...

  12. Medienerziehung in der Familie : Regeln und Motive, Umfang und Auswirkungen der Nutzung von Computer, Fernseher und Videokonsole

    OpenAIRE

    Röhr-Sendlmeier, Una M.; Götze, Irina; Stichel, Rebecca

    2008-01-01

    'Ausgehend von einem Forschungsüberblick über förderliche und abträgliche Auswirkungen der Fernseh- und Computernutzung werden empirische Daten zur familiären Medienerziehung vorgestellt. In zwei aufeinander aufbauenden Studien mit 282 Dritt- und Viertklässlern und ihren Eltern wurden das Ausmaß der Mediennutzung, Regeln und Motive der Medienerziehung sowie die Lesekompetenz der Kinder erhoben. Schon bei insgesamt moderaten Gesamtnutzungsdauern korrelierte die Höhe des Fernseh- und Computerko...

  13. Zentren und Peripherien in Europa : eine Analyse und Interpretation der Verschiebungen zwischen dem ersten und dritten Viertel des 20. Jahrhunderts

    OpenAIRE

    Haller, Max; Höllinger, Franz

    1995-01-01

    In den Sozialwissenschaften bezeichnet man mit den Begriffen 'Zentrum' und 'Peripherie' die wirtschaftlichen, politischen und kulturellen Ungleichheiten und Abhängigkeitsverhältnisse zwischen höherentwickelten, dominanten Regionen und Staaten und wenig bzw. unterentwickelten Staaten und Regionen. Der vorliegende Beitrag diskutiert zunächst vier paradigmatische Ansätze, die diesen Sachverhalt zu erklären suchen: der wirtschaftlich-geographisch-funktionale Ansatz (Christaller), der politökonomi...

  14. Nutzerorientiertes Management von materiellen und immateriellen Informationsobjekten

    OpenAIRE

    Hübsch, Chris

    2001-01-01

    Schaffung einer stabilen, erweiterbaren und skalierbaren Infrastruktur für die Bereitstellung von Diensten im Umfeld von Bibliotheken und ähnlichen wissensanbietenden Einrichtungen unter Verwendung von XML-RPC und Python.

  15. Role of the Phosphorylation of mTOR in the Differentiation of AML Cells Triggered with CD44 Antigen

    KAUST Repository

    Darwish, Manar M

    2013-05-01

    Acute myeloid leukemia (AML) is a hematological disorder characterized by blockage of differentiation of myeloblasts. To date, the main therapy for AML is chemotherapy. Yet, studies are seeking a better treatment to enhance the survival rate of patients and minimize the relapsing of the disease. Since the major problem in these cells is that they are arrested in cellular differentiation, drugs that could induce their differentiation have proven to be efficient and of major interest for AML therapy. CD44 triggering appeared as a promising target for AML therapy as it has been shown that specific monoclonal antibodies, such as A3D8 and H90, reversed the blockage of differentiation, inhibited the proliferation of all AML subtypes, and in some cases, induced cell apoptosis. Studies conducted in our laboratory have added strength to these antibodies as potential treatment for AML. Indeed, our laboratory found that treating HL60 cells with A3D8 shows a decrease in the phosphorylation of the mammalian target of Rapamycin (mTOR) kinase correlated with the inhibition of proliferation/induction of differentiation of AML cells.The relationship between the induction of differentiation and the inhibition of proliferation and the decrease of mTOR phosphorylation remains to be clarified. To study the importance of the de-phosphorylation of mTOR and the observed effect of CD44 triggering on differentiation and/or proliferation, we sought to prepare phospho-mimic mutants of the mTOR kinase that will code for a constitutively phosphorylated form of mTOR and used two main methods to express this mutant in HL60 cells: lentiviral and simple transfection (cationic-liposomal transfection).

  16. Editorial: Medien und soziokulturelle Unterschiede

    Directory of Open Access Journals (Sweden)

    Horst Niesyto

    2009-09-01

    Full Text Available Kinder, Jugendliche und Erwachsene nutzen Medien in sehr unterschiedlicher Weise. Insbesondere handlungstheoretische Ansätze der Medienforschung konnten überzeugend belegen, dass Menschen keine passive Zielscheibe von Medien sind, sondern diese aktiv nutzen. Medienrezeption und Medienaneignung wird als Teil sozialen Handelns verstanden, die Mediennutzung wird im Lebenskontext der Menschen verortet, es wird nach der Bedeutung der Medien im Alltag und für die Lebensbewältigung gefragt. Kulturtheoretisch motivierte Studien, die die Eigenleistungen der Individuen im Auswahlprozess und in der Konstruktion von Bedeutungen betonen, verdeutlichten eigensinnige Prozesse der Medienaneignung und eine Vielfalt medienkultureller Orientierungen. Im Bereich des Lernens mit Medien wurden die Chancen selbstgesteuerter Lernprozesse mit digitalen Medien in verschiedenen Forschungsprojekten herausgearbeitet. Ein kritischer Blick auf die Medienentwicklung und die Mediennutzung kann nicht verleugnen, dass es soziokulturelle Unterschiede und Formen sozialer Ungleichheit in der Mediennutzung gibt. In den letzten Jahren entstanden in diesem Zusammenhang vermehrt Studien zu Themenbereichen wie ‹Digital divide›, Zunahme medialer Wissens- und Bildungsklüfte, Bildungsbenachteiligung und Medienaneignung. Verschiedene Fachtagungen griffen die Thematik auf, z.B. der vom JFF Institut für Medienpädagogik in Forschung und Praxis und der Pädagogischen Hochschule Ludwigsburg/Abteilung Medienpädagogik veranstaltete Fachkongress «Soziale Ungleichheit – Medienpädagogik – Partizipation» am 17./18.10.2008 in Bonn und das von der Gesellschaft für Medienpädagogik und Kommunikationskultur e.V. (GMK veranstaltete Forum «Geteilter Bildschirm – Getrennte Welten?» am 21.–23.11.2008 in Rostock. In diesen Studien und Fachtagungen ging es darum herauszuarbeiten, worin soziokulturelle Unterschiede in der Medienaneignung bestehen, was die Gründe hierfür sind, wie diese

  17. Die Cestoden der Marsupialia und Monotremata

    OpenAIRE

    Zschokke, Fritz

    2011-01-01

    Ueber Bandwürmer aus Monotremen und Marsupialiern war bis heute nur wenig bekannt, und die wenigen Notizen und Abbildungen entsprechen nur in ungenügendem Maasse den Anforderungen einer wissenschaftlichen Beschreibung und der neueren, auf anatomische Merkmale sich gründenden Cestodensystematik. Im Jahre 1819 beschrieb RUDOLPHI (20) in seiner "Synopsis" unter dem Namen Taenia festiva einen Bandwurm aus den Lebergängen und der Gallenblase von Macropus giganteus, und BREMSER (3) lieferte in den ...

  18. Wiederaufleben, Legitimation und Institutionalisierung qualitativer Forschung

    OpenAIRE

    Fielding, Nigel

    2005-01-01

    Dieser Beitrag befasst sich mit dem Stellenwert qualitativer Forschungsmethoden im Universitätscurriculum unter Berücksichtigung sich wandelnder Nutzungsweisen. Hierzu gehören zunächst der Beginn und die Frühzeit qualitativer Methodologie – insbesondere die Chicagoer Schule und die Schöpfungsmythen qualitativer Soziologie – und deren Einordnung in das sozialwissenschaftliche Curriculum. Mit Strukturalismus und Funktionalismus und deren makrosoziologischer und quantitativer Affinität ist es da...

  19. Bier und Braustoffe

    Science.gov (United States)

    Taschan, Hasan; Uhlig, Reiner

    In diesem Kapitel werden die zur Bierherstellung notwendigen Rohstoffe (Brauwasser, Malz, Malzersatzstoffe, Hopfen und Hopfenprodukte, Hefe), die Bierbereitung sowie wesentliche Merkmale der verschiedenen Biersorten (z. B. Pils-, Märzen-, Weizen-, Alt-, Diät-Biere) sowie Biermischgetränke behandelt.

  20. Erwachsenenbildung und Globalisierung [Rezension

    OpenAIRE

    Grobbauer, Heidi

    2012-01-01

    Sammelrezension zu: Wolfgang Sander, Annette Scheunpflug (Hrsg.): Politische Bildung in der Weltgesellschaft. Herausforderungen, Positionen, Kontroversen. Bonn 2001 Bundeszentrale für politische Bildung (= Perspektive politischer Bildung, 2); Anne Broden, Paul Mecheril (Hrsg.): Rassismus bildet. Bildungswissenschaftliche Beiträge zu Normalisierung und Subjektivierung in der Migrationsgesellschaft. Bielefeld 2010 Transcript-Verlag; Geseko von Lüpke: Zukunft entsteht aus Krise. Antworten von Jo...

  1. Pragmatismus und Semantik

    Czech Academy of Sciences Publication Activity Database

    Peregrin, Jaroslav

    Frankfurt : ontos verlag, 2004 - (Fuhrmann, A.; Olsson, E.), s. 89-108 ISBN 3-937202-46-3. - (Epistemische Studien. Schriften zur Erkenntnis- und Wissenschaftstheorie. 4) R&D Projects: GA ČR GA401/99/0619 Institutional research plan: CEZ:AV0Z9009908 Keywords : pragmatism * semantics Subject RIV: AA - Philosophy ; Religion

  2. Arbeitsgestaltung und Mitarbeiterqualifizierung

    Science.gov (United States)

    Weiss-Oberdorfer, Werner; Hörner, Barbara; Holm, Ruth; Pirner, Evelin

    Die Wertkette gliedert ein Unternehmen in strategisch relevante Tätigkeiten, um dadurch Kostenverhalten sowie vorhandene und potenzielle Differenzierungsquellen zu verstehen. Wenn ein Unternehmen diese strategisch wichtigen Aktivitäten billiger oder besser als seine Konkurrenten erledigt, verschafft es sich einen Wettbewerbsvorteil." Michael Porter, 1985

  3. Antike triebtheoretisch und chiasmatisch

    Directory of Open Access Journals (Sweden)

    Kathrin Hönig

    2007-11-01

    Full Text Available Der disziplinenübergreifende Zugriff auf die Antike unter Einbezug der Psychoanalyse bewegt sich abseits der traditionellen philosophischen und philologischen Pfade. Der chiasmatische Ansatz ist freilich nicht unproblematisch. Er führt zu originellen Thesen, erschwert jedoch eine stringente Argumentation.

  4. Eigene Aktien und Wertpapierleihe

    OpenAIRE

    Cahn, Andreas; Ostler, Nicolas

    2008-01-01

    Wertpapierleihgeschäfte gehören heute zum Standardrepertoire bei der Durchführung von Kapitalmarkttransaktionen. Der vorliegende Beitrag geht der Frage nach, welche Möglichkeiten solche Geschäfte im Hinblick auf eigene Aktien bieten und welche Grenzen §§ 71 ff. AktG ihrem Einsatz bei eigenen Aktien ziehen.

  5. Service, Technologie und Informationskompetenz

    OpenAIRE

    Engels, Frauke; Rüter, Christian; Voß, Michael

    2007-01-01

    Der Artikel gibt eine Übersicht über die Dienstleistungen der Universitätsbibliothek und zeigt auf, welche vielfältigen Weiterentwicklungen stattgefunden haben bzw. geplant sind, um eine optimale Informationsversorgung an der Humboldt-Universität zu garantieren.

  6. Authentifizierungs- und Informationsdienst

    OpenAIRE

    Wegener, Jens

    2004-01-01

    Es werden Systeme zur Realisierung einer einheitlichen Authentifizierung von Nutzern im Hinblick auf WWW-Anwendungen an der Technischen Universtät Chemnitz und der damit verbundenen Übermittlung von Nutzerdaten untersucht. Shibboleth wird als ein prinzipiell mögliches System zur Lösung dieser Aufgabe in Form eines Tests näher betrachtet.

  7. Dynamic contrast-enhanced MRI for the evaluation of bone marrow microcirculation in hematologic malignancies before and during thalidomide therapy; Dynamische kontrastverstaerkte MRT zur Beurteilung der Knochenmarksmikrozirkulation bei malignen haematologischen Erkrankungen vor und waehrend einer Thalidomidtherapie

    Energy Technology Data Exchange (ETDEWEB)

    Scherer, A.; Wittsack, H.J.; Engelbrecht, V.; Moedder, U. [Duesseldorf Univ. (Germany). Inst. fuer Diagnostische Radiologie; Strupp, C.; Germing, U.; Gattermann, N.; Haas, R. [Duesseldorf Univ. (Germany). Klinik fuer Haematologie, Onkologie und klinische Immunologie; Willers, R. [Duesseldorf Univ. (Germany). Universitaetsrechenzentrum

    2002-03-01

    Purpose. The aim of the study was to measure microcirculation parameters by dynamic contrast-enhanced MRI (d-MRI) and to evaluate the anti-angiogentic effects during treatment with thalidomide in different hematologic malignancies. Methods. In 20 healthy normal persons, 20 patients with myelodysplastic syndromes (MDS), 10 patients with multiple myeloma (MM) and 10 with myelofibrosis (MF) a fast gradient echo sequence (Turbo fast low angle shot 2D) with a pump controlled bolus infusion of gadolinium-DTPA was performed before and in 18 of these after beginning (average of 4,3 months) of a thalidomide therapy. Two pharmacokinetic parameters - the amplitude and exchange-rate-constant - were calculated and a statistical comparison of these values between healthy persons and patients as well as a correlation with the clinical course was executed. Results. Compared with the normal controls the patients showed a higher amplitude (normal persons 14.4{+-}5.2, MDS 24.8{+-}8.1, MF 35.9{+-}4.3, MM 23.4{+-}3.6) and exchange-rate-constant (normal persons 0.124{+-}0.042, MDS 0.136{+-}0.036, MF 0.144{+-}0.068, MM 0.131{+-}0.034). In the d-MRI-follow-up examinations a signficant (p<0.005) reduction of the amplitude and exchange rate constant values was evident in 14 of 18 patients undergoing a thalidomide therapy. Clinically all of these patients showed a therapy responding with complete or partial diseases remission. Conclusions. In patients with hematologic malignancies significantly higher d-MRI-microcirculation parameters of the lumbar spine can be demonstrated than in normal persons. During anti-angiogenetic treatment with thalidomide a decrease of these values was observed in case of a responding to therapy. (orig.) [German] Fragestellung. Unser Ziel war die Beurteilung der Mikrovaskularisation und des antiangiogenetischen Effektes einer Thalidomidtherapie mittels dynamischer kontrastverstaerkter MRT (d-MRT) bei unterschiedlichen haematologischen Erkrankungen. Methodik. Bei 20

  8. Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG

    OpenAIRE

    Ho, Phoenix A.; Kopecky, Kenneth J.; Alonzo, Todd A.; Gerbing, Robert B.; Miller, Kristen L.; Kuhn, Julia; Zeng, Rong; Ries, Rhonda E.; Raimondi, Susana C; Hirsch, Betsy A.; Oehler, Vivian; Hurwitz, Craig A.; Franklin, Janet L.; Gamis, Alan S.; Petersdorf, Stephen H.

    2011-01-01

    IDH1 SNP rs11554137 was recently reported in association with poor prognosis in normal karyotype adult acute myeloid leukemia (AML). We aimed to determine the prevalence, clinical associations, and prognostic significance of SNP rs11554137 in unselected pediatric and adult AML patients. Diagnostic marrow specimens from 527 AML patients treated on the pediatric trial Children's Oncology Group-AAML03P1 (N = 253) or adult SWOG trials (N = 274) were analyzed for the presence of the SNP. SNP rs115...

  9. Normal Hematopoietic Stem Cells within the AML Bone Marrow Have a Distinct and Higher ALDH Activity Level than Co-Existing Leukemic Stem Cells

    OpenAIRE

    Schuurhuis, Gerrit J.; Meel, Michael H.; Wouters, Floris; Min, Lisa A.; Terwijn, Monique; de Jonge, Nick A.; Kelder, Angele; Snel, Alexander N; Zweegman, Sonja; Ossenkoppele, Gert J.; Smit, Linda

    2013-01-01

    Persistence of leukemic stem cells (LSC) after chemotherapy is thought to be responsible for relapse and prevents the curative treatment of acute myeloid leukemia (AML) patients. LSC and normal hematopoietic stem cells (HSC) share many characteristics and co-exist in the bone marrow of AML patients. For the development of successful LSC-targeted therapy, enabling eradication of LSC while sparing HSC, the identification of differences between LSC and HSC residing within the AML bone marrow is ...

  10. Functional and Physical Interactions between AML1 Proteins and an ETS Protein, MEF: Implications for the Pathogenesis of t(8;21)-Positive Leukemias

    OpenAIRE

    Mao, Shifeng; Frank, Richard C.; Zhang, Jin; Miyazaki, Yasushi; Nimer, Stephen D.

    1999-01-01

    The AML1 and ETS families of transcription factors play critical roles in hematopoiesis; AML1, and its non-DNA-binding heterodimer partner CBFβ, are essential for the development of definitive hematopoiesis in mice, whereas the absence of certain ETS proteins creates specific defects in lymphopoiesis or myelopoiesis. The promoter activities of numerous genes expressed in hematopoietic cells are regulated by AML1 proteins or ETS proteins. MEF (for myeloid ELF-1-like factor) is a recently clone...

  11. AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukaemia

    OpenAIRE

    Dunne, Jenny; Gascoyne, Duncan M.; Lister, T. Andrew; Brady, Hugh J.M.; Heidenreich, Olaf; Young, Bryan D.

    2010-01-01

    A variety of genetic lesions, including chromosomal translocations, internal tandem duplications and mutations have been described in acute myeloid leukaemia (AML). Expression profiling has shown that chromosomal translocations, in particular, are associated with distinctive patterns of gene expression. AML exhibiting the translocation t(8;21), which fuses the AML1 and ETO genes, has such a characteristic expression profile. One gene whose expression is highly correlated with the presence of ...

  12. South Africa; Financial Sector Assessment Program-Anti-Money Laundering and Combating the Financing of Terrorism (AML/CFT)-Technical Note

    OpenAIRE

    International Monetary Fund

    2015-01-01

    This Technical Note discusses findings and recommendations made in the Financial Sector Assessment Program (FSAP) for South Africa in the areas of anti-money laundering and combating the financing of terrorism (AML/CFT). The AML/CFT supervisory framework for the financial sector, in particular the banking sector, has been strengthened by the amended Financial Intelligence Center (FIC) Act that took effect in 2010 and the creation of the AML/CFT supervision team within Banking Supervision Depa...

  13. Protosoziologie im Kontext : "Lebenswelt" und "System" in Philosophie und Soziologie

    OpenAIRE

    2007-01-01

    Das Forschungsprojekt PROTOSOZIOLOGIE an der J.W. Goethe-Universität Frankfurt am Main hat seit 1991 eine grundlagentheoretische Forschung auf dem Gebiet der Theoriebildung der modernen Sozialwissenschaften durchgeführt. Dabei waren die drei Kontexte Phänomenologie, System- und Sprachtheorie relevant. Die Phänomenologie der Lebenswelt und die Systemtheorie haben in der Philosophie und Soziologie des 20. Jahrhunderts – neben dem Sprachbegriff – eine paradigmatische Bedeutung. Edmund Husserls L...

  14. Dysfunktionale Einstellungen und Depression im Kindes- und Jugendalter

    OpenAIRE

    Sahyazici-Knaak, Fidan (Diplom Psychologin)

    2015-01-01

    Die vorliegende Studie beschäftigte sich mit der Bedeutung der dysfunktionalen Einstellungen für die Entwicklung von depressiven Symptomen bei Kindern und Jugendlichen. Nach der kognitiven Theorie der Depression von Beck (1967, 1996) führen dysfunktionale Einstellungen in Interaktion mit Stress zu depressiven Symptomen. Es existieren allerdings nur wenige Studien, die die longitudinale Beziehung zwischen den dysfunktionalen Einstellungen und der Depressivität bei Kindern und Jugendlichen unte...

  15. Hahnemanns Theorie und Praxis und das moderne Erkenntnisproblem

    OpenAIRE

    Schmidt, Josef M.

    2014-01-01

    Anschauen, Wahrnehmen und Erkennen sind in der Medizin keine trivialen Vorgänge. Die moderne konventionelle Medizin hat sich diesbezüglich der Methode des klinischen Experiments und der Statistik sowie dem Ideal einer evidenzbasierten Medizin verschrieben, deren externe Evidenz letztlich auf «Erkenntnis ohne erkennendes Subjekt» im Sinne Karl Poppers beruht. Demgegenüber verfolgt die Homöopathie auch gestalttheoretische und kognitionsbasierte Ansätze wissenschaftlicher Erkenntnis im Sinne Kar...

  16. Analyse und Vergleich von semistrukturierten und objektorientierten Datenmodellen

    OpenAIRE

    Behl, Jörg

    2002-01-01

    Diese Arbeit stellt verschiedene Datenmodelle vor und vergleicht ihre Merkmale. Die Kennzeichen eines Datenmodells werden definiert. Darauf folgt die Beschreibung vier verschiedener Datenmodelle. Dabei handelt es sich um das hierarchische, das Netzwerk-, das objekt-orientierte und das semistrukturierte Datenmodell. Die Beschreibung der Datenmodelle nimmt Bezug auf die verwendeten Datenstrukturen und die möglichen Einschränkungen, die durch die Datenmodelle vorgenommen werden können. Im Födera...

  17. Zwischen Boykott und CSR : eine Beziehungsanalyse zu Unternehmen und NGOs

    OpenAIRE

    Curbach, Janina

    2008-01-01

    "Um zur verstehenden Analyse der vielfältigen Beziehungen zwischen dem Unternehmenssektor und Nichtregierungs-Organisationen (NGOs) beizutragen, wird im vorliegenden Artikel die Idee eines hohen gesellschaftlichen Legitimationskapitals von NGOs aufgegriffen. Darauf aufbauend werden die Strategien der Einflussnahme von NGOs und ihre Einflusschancen auf Unternehmen vorgestellt und in Beziehung zu den strategischen Reaktionsmöglichkeiten von Unternehmen gesetzt. Daraus ergibt sich eine Topograph...

  18. Haptische Wahrnehmungs- und Sprachentwicklungsleistungen bei Kindergarten- und Vorschulkindern

    OpenAIRE

    Götze, Britta; Kiese-Himmel, Christiane; Hasselhorn, Marcus

    2001-01-01

    An einer Stichprobe von 101 dreieinhalb-, vier- und fünfjährigen Kindern wurden aktiver Objektwortschatzumfang, morpho-syntaktische Fähigkeiten sowie haptische Wahrnehmungsfähigkeit (Objektstereognosie, Stereognosie von Objektqualitäten) testpsychologisch erhoben. Zwischen den Variablen der haptischen Wahrnehmung und den Sprachmaßen fanden sich zum Teil bedeutsame, substantielle korrelative Zusammenhänge. Die Altersdifferenzen im Wortschatz und in den morpho-syntaktischen Fähi...

  19. Mädchenschulen zwischen Traditionalismus und Emanzipationsanspruch. Forschungsstand und Forschungsdesiderata

    OpenAIRE

    Herwartz-Emden, Leonie; Schurt, Verena; Waburg, Wiebke

    2005-01-01

    Vor dem Hintergrund weiterhin bestehender Unterschiede in Leistungen, Interessen, Selbstkonzept etc. zwischen Schülerinnen und Schülern koedukativer Schulen (PISA, TIMSS, IGLU) liefert der vorliegende Beitrag einen Überblick über aktuelle deutschsprachige und internationale Publikationen zum Thema Monoedukation und ihren Potentialen bezüglich des Erreichens von Chancengleichheit im Bildungssystem. Aufgrund der Heterogenität der vorliegenden Studien (Forschungsfragen, methodische Anlagen, Samp...

  20. Schneiden und Bohren von Knochen- und Knorpelgewebe mit Excimerlasern

    OpenAIRE

    Jahn, Renate; Dressel, Martin; Langendorff, Hans-Ulrich; Neu, Walter; Jungbluth, Karl-Heinz

    1991-01-01

    Es stellte sich die experimentelle Aufgabe, zu prüfen, inwieweit Excimerlaser zum Schneiden und Bohren an Hartgewebe verwendbar sind. Der entscheidende Vorteil liegt in der im wesenlichen athermischen Gewebsabtragung. Immer im Hinblick auf eine spätere klinische Anwendung, vor allem in tiefgelegenen und komplikationsträchtigen Operationsgebieten, werden während der Experimente generell Quarzfasern zur Transmission der Laserpulse und XeCI-Excimerlaser der Wellenlänge 308 nm benutzt. Durch Spez...

  1. Schu:Bi - Schule und Bibliothek : Bildungspartner für Lese- und Informationskompetenz

    OpenAIRE

    Autor/in nicht angegeben,

    2010-01-01

    Im Projekt "Schu:Bi - Schule und Bibliothek" haben sich die Oldenburger Bibliotheken und Schulen zusammengeschlossen, um über alle Jahrgangsstufen und Bibliothekstypen hinweg Schüler an den nachhaltigen und effizienten Umgang mit Bibliotheken heranzuführen. Dort können sie im Informationszeitalter einen selbstbestimmten und kritischen Umgang mit Texten und Informationen, egal ob sie gedruckt oder elektronisch im Internet vorliegen, lernen. Dazu wurde ein Spiralcurriculum zur Lese- und Informa...

  2. Lenalidomide and metronomic melphalan for CMML and higher risk MDS: a phase 2 clinical study with biomarkers of angiogenesis.

    Science.gov (United States)

    Buckstein, Rena; Kerbel, Robert; Cheung, Matthew; Shaked, Yuval; Chodirker, Lisa; Lee, Christina R; Lenis, Martha; Davidson, Cindy; Cussen, Mary-Anne; Reis, Marciano; Chesney, Alden; Zhang, Liying; Mamedov, Alexandre; Wells, Richard A

    2014-07-01

    Metronomic, low dose chemotherapy may have anti-angiogenic effects and augment the effects of lenalidomide in MDS and CMML. We evaluated the clinical efficacy, tolerability and anti-angiogenic effects of melphalan 2mg and lenalidomide 10mg for 21 days/28 in CMML (n=12) and higher risk MDS (n=8) patients in a prospective phase II study. The primary endpoint was overall response and secondary endpoints included survival, progression-free survival, toxicity and biomarkers of angiogenesis. The median age was 73 years, 55% were pretreated and transfusion dependent. The overall response rate was 3(15%) of 19 evaluable patients but 25% in CMML and 33% in pCMML. Dose reductions and/or delays were common due to myelosuppression. Transient spikes in circulating endothelial cells that declined below baseline were seen in responders and patients with CMML, suggesting anti-angiogenic activity. In conclusion, lenalidomide and metronomic low dose melphalan demonstrate signals of clinical and possible anti-angiogenic activity in patients with pCMML that require future validation. This trial was registered at clinicaltrial.gov under # NCT00744536. PMID:24819395

  3. The AML1-MTG8 Leukemic Fusion Protein Forms a Complex with a Novel Member of the MTG8(ETO/CDR) Family, MTGR1

    OpenAIRE

    Kitabayashi, Issay; IDA, KOHMEI; Morohoshi, Fumiko; Yokoyama, Akihiko; Mitsuhashi, Naoko; Shimizu, Kimiko; Nomura, Nobuo; Hayashi, Yasuhide; Ohki, Misao

    1998-01-01

    The AML1-CBFβ transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most frequent target of chromosomal rearrangements in human leukemia. In the t(8;21) translocation associated with acute myeloid leukemia (AML), the AML1(CBFA2/PEBP2αB) gene is juxtaposed to the MTG8(ETO/CDR) gene. We show here that the resultant AML1-MTG8 gene product specifically and strongly interacts with an 85-kDa phosphoprotein. Molecular cloning of cDNA indicated that the...

  4. AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion

    OpenAIRE

    Mulloy, James C.; Jankovic, Vladimir; Wunderlich, Mark; Delwel, Ruud; Cammenga, Jorg; Krejci, Ondrej; Zhao, Hui; Valk, Peter J. M.; Lowenberg, Bob; Nimer, Stephen D.

    2005-01-01

    The AML1-ETO fusion protein, generated by the t(8;21) in acute myeloid leukemia (AML), exerts dominant-negative functions and a variety of gains of function, including a positive effect on the growth of primary human CD34+ hematopoietic stem/progenitor cells. We now show that AML1-ETO expression up-regulates the level of TRKA mRNA and protein in these cells and that AML1-ETO-expressing CD34+ hematopoietic cells grown in the presence of five early-acting hematopoietic cytokines further prolife...

  5. Monitoring response and resistance to the novel arsenical darinaparsin in an AML patient

    Directory of Open Access Journals (Sweden)

    Torsten HolmNielsen

    2013-02-01

    Full Text Available Acute myeloid leukemia (AML with inversion of chromosome 3 is characterized by overexpression of EVI1 and carries a dismal prognosis. Arsenic-containing compounds have been described to be efficacious in malignancies overexpressing EVI1. Here we describe a case of AML with inv(3(q21q26.2 treated with the organic arsenical darinaparsin. Using a “personalized medicine approach”, different arsenicals were screened for anti-leukemic effect against the patient’s cells ex vivo. The most promising compound, darinaparsin, was selected for in vivo treatment. Clinical effect was almost immediate, with a normalization of temperature, a stabilization of white blood cell (WBC counts and an increased quality of life. Longitudinal monitoring of patient response and resistance incorporating significant correlative studies on patient derived blood samples over the two cycles of darinaparsin given to this patient allowed us to evaluate potential mechanisms of response and resistance. The anti-leukemic effects of darinaparsin correlated with inhibition of the alternative NF-κB pathway and production of the inflammatory cytokine IL-8. Emergence of resistance was suspected during treatment cycle 2 and supported by xenograft studies in nude mice. Darinaparsin resistance correlated with an attenuation of the effect of treatment on the alternative NF-κB pathway. The results from this patient indicate that darinaparsin may be a good treatment option for inv(3 AML and that inhibition of the alternative NF-κB pathway may be predictive of response. Longitudinal monitoring of disease response as well as several correlative parameters allowed for the generation of novel correlations and predictors of response to experimental therapy in a heavily pretreated patient.

  6. Ödipus und Popkultur

    Directory of Open Access Journals (Sweden)

    Andrea Schüler

    2003-03-01

    Full Text Available Marjorie Garber inspiziert in ihrer ebenso eloquenten wie materialreichen Abhandlung die abendländische Geistes- und Kulturgeschichte von der Antike bis zur Postmoderne und kommt zu dem Ergebnis, dass Bisexualität allgegenwärtig und zugleich kulturell und politisch unsichtbar ist. Die zahlreichen Beispiele bisexuellen Begehrens, die sich sowohl unter literarischen Figuren als auch bei bekannten historischen Personen finden lassen, seien von ihren Interpret/-innen stets der Dichotomie Homo- oder Heterosexualität unterworfen worden. Erfahrungen, die dieser binären Opposition widersprechen, würden als „Phase“, „Experiment“, „Verirrung“, „Selbstbetrug“ usw. abgewertet. Im Sinne postmoderner Identitätskritik plädiert die Autorin für eine Befreiung der Erotik von solchen Normierungen und preist das subversive und transgressive Potential menschlicher Sexualität jenseits der Kategorien homo- hetero- oder bisexuell.

  7. The Agent Modeling Language AML A Comprehensive Approach to Modeling Multi-agent Systems

    CERN Document Server

    Cervenka, Radovan

    2007-01-01

    Multi-agent systems are already a focus of studies for more than 25 years. Despite substantial effort of an active research community, modeling of multi-agent systems still lacks complete and proper definition, general acceptance, and practical application. Due to the vast potential of these systems e.g., to improve the practice in software and to extent the applications that can feasibly be tackled, this book tries to provide a comprehensive modeling language - the Agent Modeling Language (AML) - as an extension of UML 2.0, concentrating on multi-agent systems and applications.

  8. Two methods for the quantitative analysis of surface antigen expression in acute myeloid leukemia (AML).

    OpenAIRE

    Jolanta Woźniak

    2004-01-01

    The expression of lineage molecules (CD13 and CD33), c-Kit receptor (CD117), CD34, HLA-DR and adhesion molecule CD49d was assessed in acute myeloid leukemia (AML) blast cells from 32 cases, using direct and indirect quantitative cytometric analysis. High correlation (r=0.8) was found between antigen expression intensity values calculated by direct analysis method (ABC) and by indirect analysis method (RFI). Moreover, the differences in expression intensity of CD13, CD117 and CD34 antigens wer...

  9. Pressurized grout remote backfilling at AML sites near Beulah and Zap, North Dakota

    International Nuclear Information System (INIS)

    The Abandoned Mine Lands (AML) Division of the North Dakota Public Service Commission (PSC) is charged with the reclamation of hazardous abandoned mine sites in North Dakota. Several underground lignite coalmines were operated near the cities of Beulah and Zap, North Dakota, from the early 1900's until about 1955. Coal seams in this area were relatively thick and the overburden generally shallow. As these mines have deteriorated with time, deep collapse features, or sinkholes, have surfaced in many areas. These features are very dangerous, especially when they occur at or near residential and commercial areas and public roads. In the past five years, sinkholes have surfaced beneath a commercial building (boat dealership, lounge, and gas station) and beneath a nearby occupied mobile home north of Beulah. sinkholes have also surfaced near KHOL Radio Station in Beulah and in the right of way of a public road south of Zap. The AML Division has conducted several emergency sinkhole-filling projects in these areas. In 1995--97, the AML Division conducted exploratory drilling which confirmed the presence of collapsing underground mines at these sites. The remediation of these sites around Beulah/Zap will take place over several years and involve three or more separate contracts due to budget considerations. In 1997, the AML Division began reclamation at these sties utilizing pressurized grout remote backfilling. In this technique, a cementitious grout is pumped through cased drill holes directly into the mine cavities to fill them and thereby stabilize the surface from collapse. The successful contractor for Phase One of the project was The Concrete Doctor, Inc. (TCDI). This paper will concentrate on Phase One of this work performed from June through September 1997. This project is especially interesting because grout was pumped through holes drilled inside the occupied commercial building. Grout was also pumped through angled holes that intercepted mined workings directly

  10. The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)

    OpenAIRE

    Elliot, Kathleen; Tooze, Janet A.; Geller, Rachel; Powell, Bayard L.; Pardee, Timothy S.; Ritchie, Ellen; Kennedy, LeAnne; Callahan, Kathryn E.; Klepin, Heidi D.

    2014-01-01

    We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥4 vs. ≤1) was associated with increased 30-day mortality (OR=9.98, 95% CI=1.18–84.13), lower odds of complete remission status (OR=0.20, 95% CI=0.06–0.65), and higher overall mortality (HR=2.13, ...

  11. Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission

    Directory of Open Access Journals (Sweden)

    Merk Martina

    2011-09-01

    Full Text Available Abstract Background Active dendritic cell (DC immunization protocols are rapidly gaining interest as therapeutic options in patients with acute myeloid leukemia (AML. Here we present for the first time a GMP-compliant 3-day protocol for generation of monocyte-derived DCs using different synthetic Toll-like receptor (TLR agonists in intensively pretreated patients with AML. Methods Four different maturation cocktails were compared for their impact on cell recovery, phenotype, cytokine secretion, migration, and lymphocyte activation in 20 AML patients and 25 healthy controls. Results Maturation cocktails containing the TLR7/8 agonists R848 or CL075, with and without the addition of the TLR3 agonist poly(I:C, induced DCs that had a positive costimulatory profile, secreted high levels of IL-12(p70, showed chemotaxis to CCR7 ligands, had the ability to activate NK cells, and efficiently stimulated antigen-specific CD8+ T cells. Conclusions Our results demonstrate that this approach translates into biologically improved DCs, not only in healthy controls but also in AML patients. This data supports the clinical application of TLR-matured DCs in patients with AML for activation of innate and adaptive immune responses.

  12. Pre-transplant MRD predicts outcome following reduced-intensity and myeloablative allogeneic hemopoietic SCT in AML.

    Science.gov (United States)

    Anthias, C; Dignan, F L; Morilla, R; Morilla, A; Ethell, M E; Potter, M N; Shaw, B E

    2014-05-01

    The presence of minimal residual disease (MRD) by multiparametric flow cytometry (MFC) has been associated with adverse outcomes in AML patients treated with chemotherapy alone, but its impact in the setting of allogeneic hematopoietic SCT (HSCT) is less clear. We studied 88 patients who underwent myeloablative (MA) or reduced-intensity conditioned allogeneic HSCT for AML in first or subsequent remission at our center. MRD status was determined using three-color MFC on pre-HSCT BM aspirates, and patients were stratified by MRD status into MRD-negative, low-level MRD-positive (<1%) or high-level MRD-positive groups (1-4.9%). Two-year survival estimates in these groups were 66.8%, 51% and 30%, respectively (P=0.012), and 2-year estimates of relapse were 7.6, 37 and 70% (P<0.001). Pre-HSCT MRD was related to disease characteristics including secondary AML (P=0.002) and primary induction failure (P=0.005), but, despite these strong correlations, MRD remained independently associated with poorer survival in multivariate analysis (hazard ratio, 1.92; P=0.014). Pre-HSCT MRD is associated with adverse clinical outcomes in AML patients undergoing reduced-intensity or MA HSCT in first or subsequent remission and should be integrated into transplant strategies for patients with AML. PMID:24510069

  13. Qualitative Forschung und das Unbewusste

    OpenAIRE

    Meek, Harriet W.

    2003-01-01

    Wir kennen unser Forschungsdesign, wissen, wie die Daten zu ordnen sind, welche Fragen wir stellen, welche Methoden wir verwenden und vieles andere, was Sinn zum Vorschein bringt und manchmal auch verschwinden lässt. Dabei verhalten wir uns meist so, als verliefen diese Entscheidungsprozesse logisch, während de facto sehr oft intuitive Schritte notwendig sind. Die Autorin geht davon aus, dass unbewusste Prozesse ein unerlässlicher Bestandteil qualitativer Forschung sind und wesentlicher Ansat...

  14. Realoptionen - Finanzoptionen: Gemeinsamkeiten und Unterschiede

    OpenAIRE

    Spremann, Klaus

    1999-01-01

    Problemstellung: In den letzten Jahren haben sich Realoptionen zunehmend als fruchtbarer Ansatz im Capital Budgeting und bei der Unternehmensbewertung erwiesen. Zudem hat sich die von Finanzoptionen bekannten Replikationsportfolios als hilfreich für die Bewertung auch von Realoptionen herausgestellt. So entsteht die Frage, ob es Parallelen zwischen Finanzoptionen und Realoptionen gibt und wie weit sie gehen. Ziele des Beitrags: 1. Optionen lassen sich unter verschiedenen Gesichtspunkten b...

  15. Pyramidenbau mit Rampen und Seilwinden

    OpenAIRE

    Müller-Römer, Frank

    2008-01-01

    Ziel dieser Arbeit war es - ausgehend vom Stand der aktuellen ägyptologischen Forschung - die wichtigsten der bisher bekannt gewordenen Hypothesen zum Bau der Pyramiden und entsprechende Bauvorschläge nach wissenschaftlichen Methoden zu analysieren und daraufhin zu überprüfen, inwieweit die Pyramiden des AR danach errichtet werden konnten. Darauf aufbauend wurde eine eigene, aus den archäologischen Befunden ableitbare und in sich widerspruchsfreie Hypothese für den Bau der Stufenpyramiden im ...

  16. Geschichte und Trends im IR

    OpenAIRE

    Portmann, Edy

    2007-01-01

    Diese Seminararbeit wurde im Rahmen des Seminars Angewandtes Information Retrievalgeschrieben und beschäftigt sich mit der Geschichte der Daten, der Internetgeschichte und dem untrennbar dazugehörenden Information Retrieval, welches als Wiedergewinnung vonbereits zur Verfügung stehenden Daten gesehen werden kann.In einem ersten Teil befasst sich diese Arbeit mit der Geschichte der menschlichen Daten-sammlung und Speicherung. Hier wird die Geschichte von den Anfängen der Datensammlungbis hin z...

  17. Conjoint-Analyse und Marktsegmentierung

    OpenAIRE

    Steiner, Winfried J.; Baumgartner, Bernhard

    2003-01-01

    Die Marktsegmentierung zählt neben der Neuproduktplanung und Preisgestaltung zu den wesentlichen Einsatzgebieten der Conjoint-Analyse. Neben traditionell eingesetzten zweistufigen Vorgehensweisen, bei denen Conjoint-Analyse und Segmentierung in zwei getrennten Schritten erfolgen, stehen heute mit Methoden wie der Clusterwise Regression oder Mixture-Modellen neuere Entwicklungen, die eine simultane Segmentierung und Präferenzschätzung ermöglichen, zur Verfügung. Der Beitrag gibt einen Überblic...

  18. Lokales Handwerk: Dienstleistungen und Unternehmensnetzwerke

    OpenAIRE

    Cupok, Uta

    2000-01-01

    Das Handwerk nimmt als größter Arbeitgeber (neben der Industrie) und Ausbilder eine zentrale Funktion bei dem Wandel von der Industrie- zur Dienstleistungsgesellschaft ein. Um so wichtiger ist es, genauer zu analysieren, wie sich „das handwerkliche Arbeiten“ im Zuge von Globalisierung, Ökologisierung, Tertiarisierung und Computerisierung gravierend verändert, welche Marktchancen darin stecken und wie die beteiligten Akteure darauf reagieren müssen. Einerseits ist das Handwerk traditionell gep...

  19. Textilbeton in Theorie und Praxis

    OpenAIRE

    2011-01-01

    Seit nunmehr über einem Jahrzehnt arbeiten die beiden Sonderforschungsbereiche 528 und 532 der Deutschen Forschungsgemeinschaft (DFG) an der Verwendung technischer Textilien im Bauwesen. An der RWTH Aachen (SFB 532) wurde in erster Linie der innovative Verbundwerkstoff „Textilbewehrter Beton“ untersucht, wobei das Ziel dünnwandige und hochbelastbare Betonbauteile waren. An der TU Dresden (SFB 528) wurde in erster Linie die Verwendung von technischen Textilien für die Verstärkung und Instandse...

  20. Latein und Volkssprache im Gottesdienst

    OpenAIRE

    Selle, Monika

    2001-01-01

    Das Zweite Vatikanische Konzil (1962-1965) hat durch seine Entscheidung, neben der lateinischen Sprache für die Feier des Gottesdienstes auch die Volkssprache zu gestatten, den Weg für die nachkonziliare Liturgiereform und die Erneuerung der liturgischen Bücher in besonderer Weise vorgezeichnet. In der Studie werden die während der Arbeit an der Liturgiekonstitution vorgebrachten Argumente für und wider die volkssprachige Liturgie dargelegt, analysiert und kritisch gewertet.

  1. Factors associated with hematopoietic cell transplantation (HCT) among patients in a population-based study of myelodysplastic syndrome (MDS) in Minnesota.

    Science.gov (United States)

    Smith, Angela R; Warlick, Erica D; Roesler, Michelle A; Poynter, Jenny N; Richardson, Michaela; Nguyen, Phuong; Cioc, Adina; Hirsch, Betsy; Ross, Julie A

    2015-10-01

    Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder characterized by dysplastic changes in the bone marrow, ineffective erythropoiesis, and an increased risk of developing acute myeloid leukemia. Treatment planning for patients with MDS is a complex process, and we sought to better characterize hematopoietic cell transplantation (HCT) outcomes and the factors that play into decision-making regarding referral of adults with MDS for definitive therapy with HCT. Patients enrolled in a population-based study of MDS between April 2010 and January 2013 who underwent HCT within the first year after enrollment were included in this analysis. Age- and risk-matched MDS patient controls also enrolled during that time period were used as a comparison. Survival was significantly better in the HCT group (48 vs. 21 %, log-rank p value 0.009). Non-HCT patients were more likely to have comorbidities, and HCT patients were more likely to have a college degree and an income >$80,000. All three of these variables were independently associated with HCT, but none impacted survival. Patients with MDS in our study who underwent HCT had better survival than a comparable group of patients who did not undergo HCT. With refined treatment techniques, more patients may be able to be considered for this therapy. More work needs to be done to determine why education and income appear to impact the decision to pursue HCT, but these factors may impact referral to an academic center where aggressive therapy like HCT is more likely to be considered. PMID:26063191

  2. Haploidentical Stem Cell Transplant for Treatment Refractory Hematological Malignancies

    Science.gov (United States)

    2009-02-12

    Acute Lymphoblastic Leukemia (ALL); Acute Myeloid Leukemia (AML); Secondary AML; Myelodysplastic Syndrome (MDS); Secondary MDS; Chronic Myeloid Leukemia; Juvenile Myelomonocytic Leukemia (JMML); Paroxysmal Nocturnal Hemoglobinuria (PNH); Lymphoma, Non-Hodgkin; Hodgkin Disease

  3. Treatment Option Overview (Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies)

    Science.gov (United States)

    ... time, MDS may become AML. Transient myeloproliferative disorder (TMD) is a type of MDS. This disorder of ... of life. Infants who have Down syndrome and TMD have an increased chance of developing AML before ...

  4. Stages of Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

    Science.gov (United States)

    ... time, MDS may become AML. Transient myeloproliferative disorder (TMD) is a type of MDS. This disorder of ... of life. Infants who have Down syndrome and TMD have an increased chance of developing AML before ...

  5. General Information about Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

    Science.gov (United States)

    ... time, MDS may become AML. Transient myeloproliferative disorder (TMD) is a type of MDS. This disorder of ... of life. Infants who have Down syndrome and TMD have an increased chance of developing AML before ...

  6. Treatment Options for Childhood Acute Myeloid Leukemia, Childhood Chronic Myelogenous Leukemia, Juvenile Myelomonocytic ...

    Science.gov (United States)

    ... time, MDS may become AML. Transient myeloproliferative disorder (TMD) is a type of MDS. This disorder of ... of life. Infants who have Down syndrome and TMD have an increased chance of developing AML before ...

  7. A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells.

    OpenAIRE

    Y. W. Zhang; Bae, S C; G Huang; Fu, Y. X.; Lu, J.; Ahn, M. Y.; Kanno, Y; Kanno, T; Ito, Y.

    1997-01-01

    The gene AML1/PEBP2 alphaB encodes the alpha subunit of transcription factor PEBP2/CBF and is essential for the establishment of fetal liver hematopoiesis. Rearrangements of AML1 are frequently associated with several types of human leukemia. Three types of AML1 cDNA isoforms have been described to date; they have been designated AML1a, AML1b, and AML1c. All of these isoforms encode the conserved-Runt domain, which harbors the DNA binding and heterodimerization activities. We have identified ...

  8. Sorafenib plus all-trans retinoic acid for AML patients with FLT3-ITD and NPM1 mutations.

    Science.gov (United States)

    Guenounou, Sarah; Delabesse, Eric; Récher, Christian

    2014-12-01

    Knowledge of the molecular basis of acute myeloid leukaemia has increased considerably in the past few years, and therapies targeting specific molecular defects of this disease are intensively investigated. Patients with both NPM1 and FLT3-ITD mutations encompass 20% of cytogenetically normal AML. The multikinase and FLT3 inhibitor, sorafenib, has shown some efficacy in patients with relapsed FLT3-ITD(+) AML. In addition, it is suggested that all-trans retinoic acid (ATRA) used in combination with chemotherapy has shown to improve outcome of patients harbouring NPM1 mutations. We report here the clinical course of three patients with refractory or relapsed FLT3-ITD(+) /NPM1(+) AML who achieved significant response upon sorafenib and ATRA combination. PMID:24689895

  9. Stochastic hypothesis of transition from inborn neutropenia to AML: Interactions of cell population dynamics and population genetics

    Directory of Open Access Journals (Sweden)

    Marek eKimmel

    2013-04-01

    Full Text Available We present a stochastic model of driver mutations in the transition from severe congenital neutropenia to myelodysplastic syndrome to acute myeloid leukemia (AML. The model has the form of a multitype branching process. We derive equations for the distributions of the times to consecutive driver mutations and set up simulations involving a range of hypotheses regarding acceleration of the mutation rates in successive mutant clones. Our model reproduces the clinical distribution of times at diagnosis of secondary AML. Surprisingly, within the framework of our assumptions, stochasticity of the mutation process is incapable of explaining the spread of times at diagnosis of AML in this case; it is necessary to additionally assume a wide spread of proliferative parameters among disease cases. This finding is unexpected but generally consistent with the wide heterogeneity of characteristics of human cancers.

  10. Wirtschaft und politische Erwachsenenbildung : Chancen und Grenzen von Kooperationsansätzen und Handlungsfeldern

    OpenAIRE

    Zeller, Melanie

    2003-01-01

    Die Arbeit knüpft an die Synthesediskussion und neuere Diskussionen um eine Öffnung politischer Bildung, wie zum Beispiel der hier relevanten beruflichen Bildung, an. Insgesamt zeigt sie der politischen Erwachsenenbildung neue Tendenzen in Betrieben und damit völlig neue Ansatzpunkte für die Diskussion auf und hinterfragt dabei kritisch die Rolle der politischen Bildner. Ziel der Forschungsarbeit war es, am Beispiel von vier Großunternehmen – BASF AG, Dresdner Bank AG, Siemens AG und Otto Ver...

  11. The clinical importance of myeloid antigen coexpression and TEL-AML1 mutation in patients with childhood acute lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    Ayşen Türedi Yıldırım

    2013-03-01

    Full Text Available Objective: In this study, we aim to investigate the relationship,if any, between clinical features, prognosis, and thecoexpressions and TEL-AML1 mutation in patients withacute lymphoblastic leukemia (ALL.Methods: Eigthy-three patients with acute lymphoblasticleukemia were retrospectively examined. Age, gender,White blood cell count, hemoglobin level, platelet count,ALL subtypei (B or T ALL, risk groups, surface antigensdeteceted by flow cytometry, existence of TEL-AML1 mutations,response, remission and relapse status at 8., 15.ve 33. Days of treatment were recorded and analyzed.Results: 15 (18% out of 83 were identified with aberrantantigen expression. Of these patients, twelve (14.4%had myeloid antigen coexpression (CD13 and/or CD33,two with B cell ALL had CD2 and CD7 coexpressions respectively,one with T cell ALL had CD19 coexpression.No significant differences were found between patientswith and without myeloid antigen coexpression in terms ofhemoglobin levels, white blood cells and platelet counts,responses given on the 8th, 15th, and 30th days on the treatment,risk groups, and relapse (p>0.05. Myeloid antigencoexpression was found in 4 of 13 patients who were identifiedwith TEL-AML1 mutation. No significant relationshipwas found between this mutation and coexpressions. Norelapse and exitus were observed in four patients with coexpressionand TEL-AML1.Conclusion: The prognosis and clinical features showsno statistically significant relationship with the presence ofneither Myeloid antigen expression nor TEL-AML1 mutation.We believe, however, the future studies involving biggersample sizes will prove to be useful in terms of moreconvincing results. J Clin Exp Invest 2013; 4(1: 90-94Key words: Acute lenfoblastic leukemia, coexpression,TEL-AML1 mutation, prognosis

  12. Cellular intrinsic mechanism affecting the outcome of AML treated with Ara-C in a syngeneic mouse model.

    Directory of Open Access Journals (Sweden)

    Wenjun Zhao

    Full Text Available The mechanisms underlying acute myeloid leukemia (AML treatment failure are not clear. Here, we established a mouse model of AML by syngeneic transplantation of BXH-2 derived myeloid leukemic cells and developed an efficacious Ara-C-based regimen for treatment of these mice. We proved that leukemic cell load was correlated with survival. We also demonstrated that the susceptibility of leukemia cells to Ara-C could significantly affect the survival. To examine the molecular alterations in cells with different sensitivity, genome-wide expression of the leukemic cells was profiled, revealing that overall 366 and 212 genes became upregulated or downregulated, respectively, in the resistant cells. Many of these genes are involved in the regulation of cell cycle, cellular proliferation, and apoptosis. Some of them were further validated by quantitative PCR. Interestingly, the Ara-C resistant cells retained the sensitivity to ABT-737, an inhibitor of anti-apoptosis proteins, and treatment with ABT-737 prolonged the life span of mice engrafted with resistant cells. These results suggest that leukemic load and intrinsic cellular resistance can affect the outcome of AML treated with Ara-C. Incorporation of apoptosis inhibitors, such as ABT-737, into traditional cytotoxic regimens merits consideration for the treatment of AML in a subset of patients with resistance to Ara-C. This work provided direct in vivo evidence that leukemic load and intrinsic cellular resistance can affect the outcome of AML treated with Ara-C, suggesting that incorporation of apoptosis inhibitors into traditional cytotoxic regimens merits consideration for the treatment of AML in a subset of patients with resistance to Ara-C.

  13. Nodale Spektralelemente und unstrukturierte Gitter - Methodische Aspekte und effiziente Algorithmen

    OpenAIRE

    Fladrich, Uwe

    2012-01-01

    Die Dissertation behandelt methodische und algorithmische Aspekte der Spektralelementemethode zur räumlichen Diskretisierung partieller Differentialgleichungen. Die Weiterentwicklung einer symmetriebasierten Faktorisierung ermöglicht effiziente Operatoren für Tetraederelemente. Auf Grundlage einer umfassenden Leistungsanalyse werden Engpässe in der Implementierung der Operatoren identifiziert und durch algorithmische Modifikationen der Methode eliminiert.

  14. Thiazide und Osteoporose

    Directory of Open Access Journals (Sweden)

    Pfeilschifter J

    1999-01-01

    Full Text Available Thiazide hemmen die Kalziumausscheidung. Über diese kalziumsparende Wirkung und über mögliche zusätzliche direkte Wirkungen auf den Knochenstoffwechsel üben sie eine günstige Wirkung auf die Umbaubilanz des Knochens aus. Thiazide können dadurch den Alternsverlust an Knochenmasse vermindern. In mehreren Studien wurde eine verminderte Frakturinzidenz unter Thiazideinnahme beobachtet. Eine randomisierte, prospektive Studie zur Wirkung der Thiazide auf die Frakturrate steht allerdings noch aus. Die positive Wirkung der Thiazide auf den Kalziumhaushalt sollte bei der Auswahl eines Antihypertensivums für einen Patienten mit einem arteriellen Hypertonus in die Entscheidung mit einbezogen werden, vor allem, wenn dieser Patient gleichzeitig eine Osteoporose hat oder ein Risiko für eine Osteoporose aufweist. Besonders günstig ist der Einsatz der Thiazide bei osteoporotischen Patienten mit einer Hyperkalziurie und Nephrolithiasis, bei denen eine zusätzliche Kalziumgabe problematisch wäre.

  15. Hegel und Gorgias

    DEFF Research Database (Denmark)

    Huggler, Jørgen

    Hegel und Gorgias /Jørgen Huggler (University of Aarhus, Denmark) (huggler(at)dpu.dk) Hegels Verständnis des Sophist Gorgias von Leontinoi in den Vorlesungen über die Geschichte der Philosophie gründet auf seine eigene Interpretation der Eleaten, insbesondere Zenon. Aufgrund eigener philosophischer...... Bemühungen hatte Hegel eine einzigartige Interpretation entwickelt über diese Gruppe von vorsokratischen Philosophen. Insbesonders identifizierte er eine sogenannt "objektive" immanente Dialektik bei Zenon. Nach Hegel haben die Sophisten, mit ihrem Konzept der „Bildung“ und ihren reflektierte Ansicht von...... „Gründen“, einen echten Beitrag zu dieser Entwicklung des griechischen Denkens geliefert. Vor allen scheint Gorgias die dialektischen Bemühungen der Eleaten fortgesetzt zu haben. Hegels Auslegung des Gorgias kann den lauwarmen Empfang der Sophisten in den deutschen Beiträgen zur Geschichte der Philosophie...

  16. Zystische Pankreastumoren: Diagnostik und Therapie

    Directory of Open Access Journals (Sweden)

    Siveke JT

    2013-01-01

    Full Text Available Die Gruppe der zystischen Pankreastumoren umfasst eine Vielzahl verschiedener Entitäten mit unterschiedlichen klinischen, morphologischen und prognostischen Charakteristika. Die Läsionen werden aufgrund der stetig verbesserten Bildgebung zunehmend früher und mit geringerer Größe diagnostiziert. Trotz des breiten Spektrums möglicher Ursachen entfallen 95 % aller zystischen Prozesse auf nur 5 Entitäten: Pankreaspseudozysten, intraduktale papilläre muzinöse Neoplasien (IPMN, muzinös-zystische Neoplasien (MCN, serös-zystische Neoplasien (SCN und solid-pseudopapilläre Neoplasien (SPN. Relevant ist die Unterscheidung neoplastischer zystischer Läsionen von nichtneoplastischen Zysten, wobei erstere weiter in seröse und muzinöse Neoplasien unterteilt werden, die wiederum ein unterschiedliches Malignitätspotenzial aufweisen. Die Differenzialdiagnose kann schwierig sein und beinhaltet eine genaue Anamnese, eine differenzierte bildgebende Diagnostik sowie pathologische und laborchemische Analysen. Die häufigsten neoplastischen Läsionen sind inzwischen die IPMN. Sie haben immer eine Gangkommunikation und können in Hauptgang- IPMN mit schlechterer Prognose und Seitengang- IPMN mit besserer, allerdings subtypabhängiger variabler Prognose eingeteilt werden. Die Seitengang- IPMN bedürfen einer genauen Risikoeinschätzung, die u. a. von Zystencharakteristika wie dem histologischen Subtyp und Risikofaktoren wie Größe, soliden Anteilen und Gangdilatation abhängt. Während unspezifische abdominelle Beschwerden keinen diagnostischen Wert haben, sind Gewichtsverlust, Ikterus, neu diagnostizierter Diabetes mellitus und erhöhte CA19-9- Werte im Serum Warnsymptome für eine maligne Entartung. Die Hauptgang-IPMN und geringer die MCN haben das größte Malignitätspotenzial der muzinösen Neoplasien und sollten wie die SPN immer reseziert werden, während SCN eine sehr geringes Malignitätspotenzial aufweisen. Kleinere Seitengang-IPMN und SCN k

  17. Pankreaskrankheiten und Diabetes mellitus

    OpenAIRE

    Galonska M; Hartje I; Büchsel R

    2012-01-01

    Pankreatogener Diabetes entsteht nach akuter oder chronischer Pankreatitis, nach Pankreasresektion, bei einem Pankreaskarzinom sowie bei autoimmuner Pankreatitis. Bei der chronischen Pankreatitis haben die Krankheitsdauer, die Ätiologie sowie das Auftreten von Kalzifikationen Bedeutung für das Ausmaß der endokrinen Dysfunktion. Die Ätiologie und das Ausmaß der Operation bestimmen die Ausprägung der endokrinen Dysfunktion nach Pankreasresektion. Etwa 85 % der Patienten mit Autoimmunp...

  18. Plagiate und unethische Autorenschaften

    OpenAIRE

    Fröhlich, Gerhard

    2006-01-01

    Die Zahl aufgedeckter Plagiate wächst weiterhin. Ihre Dunkelziffer dürfte ein Vielfaches davon betragen. Aufgrund grassierender unethischer Autorenschaften (inflationäre Ehrenautorenschaften, Ghost Writings) setzen medizinische Journale nun auf den Begriff der "Kontribuentenschaft", Großprojekte der Hochenergiephysiker auf statutarisch geregelte kollektive Autorenschaften. Welche institutionellen Leitbilder und organisatorischen Kontexte fördern die Bereitschaft zum Plagiieren bzw. unethische...

  19. Funkuhrtechnik und Funkuhrentwicklung

    OpenAIRE

    Mohr, Rainer; Schubert, Manfred

    2000-01-01

    In Deutschland ist die Physikalisch Technische Bundesanstalt (PTB) in Braunschweig für die Verbreitung der gesetzlichen Zeit verantwortlich (Zeitgesetz). Für dieses Zeitgesetz wurde die Installation des Zeitsignalund Normalfrequenzsenders DCF77 notwendig. Erste Testaussendungen gab es 1956, offizieller Sendebeginn war der 1.Januar 1959. Seit dem 1. September 1970 werden Normalfrequenz (77,5 kHz Träger) und Zeitmarken gesendet, das heißt definierte Absenkung des Trägers zu Beginn jeder Sekunde...

  20. Controlling, BWL und Privatwirtschaftslehre

    OpenAIRE

    Lingnau, Volker

    2008-01-01

    Die Controllingforschung ist ausgezogen, den Heiligen Gral der eigenständigen Führungsfunktion zu finden und mit der zerbrochenen Teetasse des Shareholder Value zurückgekehrt so ließe sich in Anlehnung an William Starbuck die Situation der Controllingforschung pointiert darstellen. Ein auch nur weitgehend allgemein akzeptiertes Verständnis von Controlling ist auch nach 30 Jahren Controlling-Forschung nicht existent, ja nicht einmal in Sicht. Man kann daher konstatieren: Das Controlling hat se...

  1. Controlling, BWL und Privatwirtschaftslehre

    OpenAIRE

    Lingnau, Volker

    2008-01-01

    Die Controllingforschung ist ausgezogen, den Heiligen Gral der eigenständigen Führungsfunktion zu finden und mit der zerbrochenen Teetasse des Shareholder Value zurückgekehrt – so ließe sich in Anlehnung an William Starbuck die Situation der Controllingforschung pointiert darstellen. Ein auch nur weitgehend allgemein akzeptiertes Verständnis von „Controlling“ ist auch nach 30 Jahren Controlling-Forschung nicht existent, ja nicht einmal in Sicht. Man kann daher konstatieren: Das Controlling ha...

  2. Osteoporosetherapie und Frakturheilung

    Directory of Open Access Journals (Sweden)

    Gruber R

    2010-01-01

    Full Text Available Ziel der Übersichtsarbeit ist es, die möglichen Auswirkungen der pharmakologischen Osteoporosetherapie auf die Frakturheilung zu beschreiben. Die Motivation, dieses Thema aufzugreifen, begründet sich (1 darin, dass Osteoporose als Risikofaktor für eine verzögerte Knochenregeneration angesehen wird und (2 dass jene Zellen, die an der Frakturheilung beteiligt sind, auch potenzielle Zielzellen einer pharmakologischen Osteoporosetherapie sind. Die Reduktion des Frakturrisikos durch Bisphosphonate, Parathormon, selektive Estrogenrezeptormodulatoren (SERMs und Strontiumranelat ist gut dokumentiert und basiert auf einer Verschiebung des Remodelings, also des Knochenumbaugleichgewichts. Frakturen treten im geringeren Ausmaß auch während dieser Behandlung auf. Kontrollierte klinische Studien, die den Einfluss der pharmakologischen Osteoporosetherapie auf die Frakturheilung untersuchen, liegen jedoch nicht vor. Hingegen gibt es zahlreiche präklinische Studien, die darauf hindeuten, dass sowohl Bisphosphonate als auch Peptide der PTH-Familie die Frakturheilung beeinflussen können. Schlussfolgerungen über deren klinische Relevanz können unter der Prämisse, dass präklinische Experimente nur bedingt die Situation im Menschen widerspiegeln, derzeit nicht angestellt werden. In den präklinischen Studien liegt zudem die Dosis der verabreichten Bisphosphonate und Peptide der PTH-Familie über jener der Osteoporosetherapie. Hinzu kommt, dass Risikofaktoren der Frakturheilung, wie metabolische Erkrankungen, die Behandlung mit Glukokortikoiden sowie fortgeschrittenes Alter in den präklinischen Studien zumeist unberücksichtigt bleiben. Klinische Studien sind demnach notwendig, um zu klären, ob eine pharmakologische Osteoporosetherapie nicht nur das Frakturrisiko reduziert, sondern auch die Frakturheilung beeinflusst.

  3. Neue Heterokumulene und Carbene

    OpenAIRE

    Ruppel, Raimund

    1999-01-01

    Die vorliegende Arbeit befaßt sich mit Matrixisolationsstudien kumulierter Kohlenstoff-Systeme, bei denen die Heteroatome Sauerstoff, Schwefel oder Stickstoff als Kettenabschluß fungieren. In den beiden ersten Teilen standen Synthese und matrixspektroskopische Charakterisierung zweier Vertreter der C2-Chalkogen-Kumulene im Mittelpunkt. Zur Darstellung von Thioxoethenon, C2OS, konnte ein der C2S2-Synthese analoges Verfahren herangezogen werden: Die photochemisch induzierte Addition ...

  4. Vorstellungen und Mathematikunterricht

    OpenAIRE

    Weber, Christof

    2007-01-01

    Die Unterrichtsforschung interessiert sich unter anderem dafür, wie Lernen mit Vorstellungen zusammenhängt. Aus ähnlichen Gründen können Vorstellungen auch für Unterrichtende aufschlussreich sein. Mit mathematischen Vorstellungsübungen liegt nun auch ein Unterrichtsinstrument vor, das im Unterricht die Vorstellungen aufgreift, die Schülerinnen und Schüler in der Auseinandersetzung mit mathematischen Fragen aufbauen.

  5. Effect of siRNA against β2-spectrin on Proliferation of AML-12 Cells%β2-spectrin的siRNA对AML-12肝细胞增殖特性的影响

    Institute of Scientific and Technical Information of China (English)

    汪志军; 涂炜; 刘芳

    2013-01-01

    Objective To investigate the effect of siRNA against β2-spectrin on proliferation, apoptosis and cell cycle of AML-12 cells (a murine hepatic cell line) . Methods AML-12 cells were pretreated with TGF-β1 for 4 h,and subsequently transfected with β2-spectrin siRNA. BrdU assay and flow cytometry were used to evaluate the proliferation, apoptosis and cell cycle of siRNA-transfected AML-12 cells. The nuclear location of Smad3/4 was detected by using double-immunofloresence staining. Results β2-spectrin gene was effectively silenced by specific synthesized siRNAs as demonstrated by the flow cytomet-ric analysis. The cell proliferation and the cell percentage of S phase were conspicuously increased after siRNA transfection. Moreover,β-spectrin silencing also resulted in the nuclear translocalization of Smad3/4. Conclusion Silencing β-spectrin expression may increase the proliferation of AML-12 cells by the nuclear translocalization of Smad3/4 , blockade of TGF-β/Smad signaling,increase in S phase cells and inhibition of cell apoptosis.%目的 应用特异性siRNA干扰小鼠肝细胞株AML-12中β2-spectrin表达,检测AML-12细胞增殖凋亡以及细胞周期的改变.方法 化学合成β2-spectrin特异性siRNA,分别转染AML-12细胞,荧光定量PCR和Western blot 确定其抑制效果.AML-12细胞经TGF-β细胞因子处理4 h后,转染β2-spectrin特异性siRNA,48 h后,BrdU标记法以及流式细胞术检测β2-spectrin沉默前后AML-12细胞增殖、凋亡以及周期变化;共聚焦技术检测干扰β2-spectrin表达对TGF-β/Smad信号通路中Smad3、Smad4核定位的影响.结果 siRNA可以高效特异沉默β2-spectrin 的表达.流式细胞术检测显示,β2-spectrin沉默促进AML-12细胞增殖,抑制凋亡,S期细胞比例显著升高.免疫荧光结果 显示,TGF-β处理后,Smad3、Smad4表达定位于细胞核,沉默β2-spectrin干扰Smad3、Smad4细胞核内定位.结论 沉默β2-spectrin的表达促进AML-12增殖,抑制凋亡,促进

  6. Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse

    OpenAIRE

    Buchholz, Frank; Refaeli, Yosef; Trumpp, Andreas; Bishop, J. Michael

    2000-01-01

    Transgenic mice have been used to explore the role of chromosomal translocations in the genesis of tumors. But none of these efforts has actually involved induction of a translocation in vivo. Here we report the use of Cre recombinase to replicate in vivo the t(8;21) translocation found in human acute myeloid leukemia (AML). As in the human tumors, the murine translocation fuses the genes AML1 and ETO. We used homologous recombination to place loxP sites at loci that were syntenic with the br...

  7. Successful management of pulmonary hemorrhage and aspergillosis in a patient with acute myeloid leukemia (AML-M3

    Directory of Open Access Journals (Sweden)

    Hulya Gunbatar

    2015-01-01

    Full Text Available A 35-year-old man presented with a one month history of gingival bleeding. He was diagnosed with Acute Myeloid Leukemia (AML-M3. During treatment he developed alveolar hemorrhage for which he was treated with a steroid. After the steroid treatment he developed a nodule, a cavitary lesion and atelectasia in the left lung. He was treated with voriconazole. After therapy with voriconazole his lesion significantly decreased. This case illustrates the efficacy and safety of antifungal therapy with voriconazole for aspergillosis complicated by AML.

  8. A case study of a large open pit uranium AML [Abandoned Mine Land] Project Gas Hills, Wyoming

    International Nuclear Information System (INIS)

    The Abandoned Mine Lands Program (AML), authorized under the Surface Mining Control and Reclamation Act of 1977 provides funding for the abatement of health and safety hazards on lands disturbed by mining prior to enactment of the Act. A good example of the implementation of the AML Program in Wyoming is the A-8 Pit. The reclamation site is located in the East Gas Hills Uranium Mining District of Wyoming. Reclamation activities include selective handling of 3.5 million cubic yards of backfill, controlling pit dewatering and water treatment, installing second order drainage channel and riprap control structures, and salvaging sufficient coversoils and topsoils for site revegetation

  9. Hypertonie und Suchtverhalten

    Directory of Open Access Journals (Sweden)

    Exner I

    2001-01-01

    Full Text Available Alkoholabusus, Rauchen, Kokaineinnahme, aber auch Koffein zeigen einen Einfluß auf den arteriellen Blutdruck, wobei die genauen Pathomechanismen noch nicht vollständig geklärt sind. Der chronische Alkoholabusus von über 30-60 g Äthanol pro Tag führt zu einem signifikanten Anstieg der Blutdruckwerte. Dieser Effekt ist reversibel. Mehrere Studien konnten unter Alkoholkarenz einen deutlichen Abfall der Blutdruckwerte zeigen. Beim Tabakabusus, hauptsächlich als Zigarettenabusus, mehren sich die Hinweise, daß Nikotin als euphorisierende Substanz der Grund für die Entstehung der Abhängigkeit ist, während die Abbrandprodukte - in erster Linie das Kohlenmonoxid - für die Wirkungen am Herz-Kreislauf-System verantwortlich sind. Durch den Einfluß auf den Gefäßtonus und das Endothel führt das Rauchen, besonders bei vorbestehenden Risikofaktoren wie Diabetes mellitus, zur Entstehung oder Verschlechterung einer arteriellen Hypertonie. Nikotinersatzprodukte zeigen keinen Einfluß auf den arteriellen Blutdruck und stellen ein sichere Option in der Raucherentwöhnung dar. Unter Kokain kommt es nur in der Phase der akuten Intoxikation zu einem exzessiven Blutdruckanstieg mit Endorganschäden, der chronische Abusus zeigt keinen Einfluß auf die Entstehung einer arteriellen Hypertonie. Die vermehrte Einnahme von Koffein kann besonders bei vorbestehender Bluthochdruckerkrankung im Alter einen Anstieg der Blutdruckwerte verursachen und sollte bei der Beratung dieser Patienten nicht vernachlässigt werden.

  10. Pankreaskrankheiten und Diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Galonska M

    2012-01-01

    Full Text Available Pankreatogener Diabetes entsteht nach akuter oder chronischer Pankreatitis, nach Pankreasresektion, bei einem Pankreaskarzinom sowie bei autoimmuner Pankreatitis. Bei der chronischen Pankreatitis haben die Krankheitsdauer, die Ätiologie sowie das Auftreten von Kalzifikationen Bedeutung für das Ausmaß der endokrinen Dysfunktion. Die Ätiologie und das Ausmaß der Operation bestimmen die Ausprägung der endokrinen Dysfunktion nach Pankreasresektion. Etwa 85 % der Patienten mit Autoimmunpankreatitis sind Diabetiker. Eine Therapie mit Immunsuppressiva kann bei diesen Patienten zu einer Besserung des Diabetes führen. Bei pankreoprivem Diabetes treten gehäuft Hypoglykämien auf. Die Behandlung sollte mittels intensivierter Insulintherapie erfolgen. Patienten mit Typ-1- und Typ-2-Diabetes weisen im Verlauf der Erkrankung häufig auch eine exokrine Pankreasinsuffizienz auf. Im höheren Lebensalter kommt es zu Veränderungen des Organs, die eine exokrine und endokrine Dysfunktion begünstigen. Es bleibt offen, ob es sich hierbei um physiologische Alterung oder Residualveränderungen nach abgelaufener subklinischer Pankreatitis handelt.

  11. Validation of the revised international prognostic scoring system (IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS (EUMDS) registry

    NARCIS (Netherlands)

    Swart, L. de; Smith, A.; Johnston, T.W.; Haase, D.; Droste, J.; Fenaux, P.; Symeonidis, A.; Sanz, G.; Hellstrom-Lindberg, E.; Cermak, J.; Germing, U.; Stauder, R.; Georgescu, O.; MacKenzie, M.; Malcovati, L.; Holm, M.S.; Almeida, A.M.; Madry, K.; Slama, B.; Guerci-Bresler, A.; Sanhes, L.; Beyne-Rauzy, O.; Luno, E.; Bowen, D.; Witte, T.J. de

    2015-01-01

    Baseline characteristics, disease-management and outcome of 1000 lower-risk myelodysplastic syndrome (MDS) patients within the European LeukaemiaNet MDS (EUMDS) Registry are described in conjunction with the validation of the revised International Prognostic Scoring System (IPSS-R). The EUMDS regist

  12. Inhibitory effect of RNAi on AML1-ETO fusion gene expression in leukemia cells%RNA干扰对急性髓系白血病AML1-ETO融合基因表达的抑制作用

    Institute of Scientific and Technical Information of China (English)

    卫菊; 李肃; 王椿; 秦尤文; 马晓霞; 谢匡成; 颜式可; 高彦荣; 蔡琦

    2008-01-01

    目的 应用RNA干扰技术抑制Kasumi-1细胞AML1-ETO融合基因的表达,研究随后出现的细胞增殖和细胞周期变化.方法 体外化学合成针对AML1-ETO融合基因的小干扰RNA(siRNA),并用电穿孔方法将AML1-ETO siRNA转染Kasumi-1细胞,以非特异性的siRNA转染细胞作阴性对照;电转带有增强型绿色荧光蛋白(EGFP)的载体,流式细胞术检测其绿色荧光以确定电转效率;荧光染料实时定量PCR及Western blot检测AML1-ETO siRNA的抑制效应;并应用CCK-8实验法检测细胞增殖率;采用碘化丙锭(PI)法测定细胞周期DNA含量.结果 电转增强EGFP的转染效率可达44.5%;电转AML1-ETO siRNA可以有效抑制AML1-ETO融合基因在mRNA和蛋白水平的表达;电转AML1-ETO siRNA 72 h后细胞增殖率[(47.90±0.02)%]低于对照组[(66.90±0.08)%](P<0.05);PI染色显示AML1-ETO siRNA转染细胞72 h后,G1期细胞比例为38.3%,对照组为31.6%,而处于G2/M期细胞分别为1.8%和2.4%.结论 化学合成的特异性siRNA能抑制AML1-ETO融合基因的表达,siRNA介导的AML1-ETo融合蛋白表达减少阻滞Kasnmi-1细胞在G1期,进而抑制细胞增殖.%Objective By inhibiting AML1-ETO fusion gene expression in Kasumi-I cells with RNAi, to investigate the changes in cell proliferation and cell cycle. Methods The small interference RNAs (siRNAs) specifically targeting the AML1-ETO fusion gene were synthesized in vitro and transfected into Ka-sumi-1 cells by electroporation, the non-specific siRNAs transfected cells were taken as control. EGFP plas-mid was transfected into Kasumi-1 cell and the transfection efficiency was detected by FCM. Inhibitory effect of siRNAs were detected by real-time RT-PCR and Western blots. Cell proliferation was measured by CCK-8 assay. DNA content was detected by PI assay. Results The transfection efficiency was 44.5%. The AML1-ETO specific siRNAs inhibited AML1-ETO expression at both mRNA and protein levels. The cell proliferation rate in si

  13. Klonierung feliner Fibrosarkomzelllinien und deren zytogenetische Charakterisierung

    OpenAIRE

    Wasieri, Jasmin

    2009-01-01

    1. Ziel der vorliegenden Arbeit war es, etablierte Zelllinien von felinen Fibrosarkomen auf ihre Klonierbarkeit zu untersuchen und sie anschließend zytogenetisch zu charakterisieren. Anhand von zellbiologischen und immunzytologischen Methoden wurde das Auftreten numerischer Chromosomen- und Zentrosomenaberrationen analysiert. Als gesunde Vergleichszelllinie dienten Hautfibroblasten eines jungen Katzenfetus, die in vitro eine schnelle Zellproliferation und ein gutes Zellwachstum zeigten. ...

  14. Die Bildgebung des Beckenbodens. Ultraschall und MRI

    OpenAIRE

    Betschart, Cornelia; PERUCCHINI, DANIELE; Fink, Daniel; SCHEINER, DAVID

    2013-01-01

    Beckenbodenpathologien können Grund sein für Genitaldeszensus, Inkontinenz und Blasen-/Darmentleerungsstörungen. Bis anhin basierte das Wissen vor allem auf klinischen Beobachtungen und anatomischen Studien. Ultraschall und MRI bringen neue Möglichkeiten in der Diagnostik und ergänzen die klinische Untersuchung.

  15. Nachhaltigkeit als Bildungsideal und als Bildungsziel

    OpenAIRE

    Pfenning, Uwe

    2015-01-01

    Darstellung der Zusammenhänge zwischen Nachhaltigkeit und Bildung, Bildung und MINT-KOnzept, EE-MINT- und Nachhaltigkeit. Diskussion der Dimensionen der Nachhaltigkeit (Zeithorizont, Interdisziplinarität, Folgenbewußtsein, Ausbilden von Kreisläufen) und Vorstellung konkreter Evaluationsergebnisse

  16. Beiträge morphologischer und anatomischer Merkmale, insbesondere der Fruchtknoten und Samenanlagen zur Taxonomie und Systematik der Bromelioideae (Bromeliaceae)

    OpenAIRE

    Duque-Thüs, Rhinaixa

    2009-01-01

    Mit der vorliegenden Arbeit wurde die Nutzbarkeit morphologischer und anatomischer Merkmale aus den Bereichen des Fruchtknotens und der Samenanlangen für die Systematik und Taxonomie der Bromelioideae (Bromeliaceae) untersucht. Hierzu wurden 30 Merkmale im Bereich des Fruchtknotens und der Samenanlagen definiert und anhand anatomischer Schnittpräparate die Verteilung der Merkmalsausprägungen an 102 Arten aus 28 (von 32) Gattungen der Unterfamilie Bromelioideae sowie zwei Vertretern der Unterf...

  17. Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.

    Directory of Open Access Journals (Sweden)

    Kiyoko Yamamoto

    Full Text Available Patients in the chronic phase (CP of chronic myelogenous leukemia (CML have been treated successfully following the advent of ABL kinase inhibitors, but once they progress to the blast crisis (BC phase the prognosis becomes dismal. Although mechanisms underlying the progression are largely unknown, recent studies revealed the presence of alterations of key molecules for hematopoiesis, such as AML1/RUNX1. Our analysis of 13 BC cases revealed that three cases had AML1 mutations and the transcript levels of wild-type (wt. AML1 were elevated in BC compared with CP. Functional analysis of representative AML1 mutants using mouse hematopoietic cells revealed the possible contribution of some, but not all, mutants for the BC-phenotype. Specifically, K83Q and R139G, but neither R80C nor D171N mutants, conferred upon BCR-ABL-expressing cells a growth advantage over BCR-ABL-alone control cells in cytokine-free culture, and the cells thus grown killed mice upon intravenous transfer. Unexpectedly, wt.AML1 behaved similarly to K83Q and R139G mutants. In a bone marrow transplantation assay, K83Q and wt.AML1s induced the emergence of blast-like cells. The overall findings suggest the roles of altered functions of AML1 imposed by some, but not all, mutants, and the elevated expression of wt.AML1 for the disease progression of CML.

  18. The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods

    International Nuclear Information System (INIS)

    The reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a chimeric transcription factor TEL-AML1 (ETV6-RUNX1). We identified directly and indirectly regulated target genes utilizing an inducible TEL-AML1 system derived from the murine pro B-cell line BA/F3 and a monoclonal antibody directed against TEL-AML1. By integration of promoter binding identified with chromatin immunoprecipitation (ChIP)-on-chip, gene expression and protein output through microarray technology and stable labelling of amino acids in cell culture, we identified 217 directly and 118 indirectly regulated targets of the TEL-AML1 fusion protein. Directly, but not indirectly, regulated promoters were enriched in AML1-binding sites. The majority of promoter regions were specific for the fusion protein and not bound by native AML1 or TEL. Comparison with gene expression profiles from TEL-AML1-positive patients identified 56 concordantly misregulated genes with negative effects on proliferation and cellular transport mechanisms and positive effects on cellular migration, and stress responses including immunological responses. In summary, this work for the first time gives a comprehensive insight into how TEL-AML1 expression may directly and indirectly contribute to alter cells to become prone for leukemic transformation

  19. Coal Mines, Abandoned - COAL_AML_MISC_IN: Abandoned Mine Lands, Entrances, Equipment, Facilities, and Dangerous Gasses in Indiana (Indiana Geological Survey, 1:24,000, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — AML_POINT, the predecessor of COAL_AML_MISC_IN, is a 1:24,000-scale point-based ESRI ArcView shapefile that shows the locations of point features associated with...

  20. Coal Mines, Abandoned - COAL_AML_HIGHWALLS_IN: Abandoned Mine Lands, Dangerous Highwalls in Indiana (Indiana Geological Survey, 1:24,000, PolyLine Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — AML_HIGHWALLS, the predecessor of COAL_AML_HIGHWAYS_IN, is a 1:24,000-scale PolyLine-based ESRI ArcView shapefile that shows the locations and extents of dangerous...

  1. Coal Mines, Abandoned - COAL_AML_FEATURES_IN: Abandoned Mine Lands, Miscellaneous Site Features in Indiana (Indiana Geological Survey, 1:24,000, Polygon Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — AML_POLY, the predecessor of COAL_AML_FEATURES_IN, is a 1:24,000-scale polygon-based ESRI ArcView shapefile that shows the locations and extents of Abandoned Mine...

  2. Frauenbewegung und Zivilgesellschaft in Russland

    Directory of Open Access Journals (Sweden)

    Ilka Borchardt

    2002-03-01

    Full Text Available Mit diesem Buch liegt nicht lediglich eine weitere Arbeit über die russische Frauenbewegung vor, sondern eine, die tatsächlich einen Beitrag zur Verbindung von Theorie und Empirie in der Frauenforschung leistet. Die aktuelle Frauenbewegung als zivilgesellschaftlicher Aktionsrahmen wird vor dem Hintergrund individueller und kollektiver Lebensentwürfe der Aktivistinnen untersucht.

  3. Der Freikolbenlineargenerator - Potenziale und Herausforderungen

    OpenAIRE

    Kock, Florian; Heron, Alex; Rinderknecht, Frank; Friedrich, Horst E.

    2013-01-01

    Das Deutsche Zenrum für Luft- und Raumfahrt (DLR) erforscht einen Freikolbenlineargenerator (FKLG) mit Gasfeder. Erstmals wurde ein solches FKLG-Gesamtsystem in Betrieb genommen und die Machbarkeit des Konzepts nachgewiesen. Das System bietet interessante Potenziale als Range Extender im PKW-Antriebsstrang.

  4. Congress Report: Demokratie und Bildung

    Directory of Open Access Journals (Sweden)

    Matthias Busch

    2010-07-01

    Full Text Available Im März 2010 fand in Mainz der Kongress der Deutschen Gesellschaft für Erziehungswissenschaft (DGfE statt. Das diesjährige Kongressthema „Bildung in der Demokratie“ berührte dabei klassische Fragestellungen und Anliegen von Lernprozessen in sozialwissenschaftlichen Domänen, also soziales, ökonomisches oder politisches Lernen. Aus diesem Grund wollen wir im vorliegenden Tagungsbericht jene Forschungstrends und Theorieprofile wiedergeben, die speziell für die sozialwissenschaftliche Bildung interessant sein dürften. Auf dem Kongress zeigten sich mit den wissensorientierten Fachdidaktiken, der beziehungsorientierten Demokratiedidaktik und einer systemisch-funktional orientierten Bildungssoziologie drei disziplinäre „Player“, die für unterschiedliche Verständnisse von sozialwissenschaftlicher Bildung stehen. Ein Austausch zwischen den Playern fand in Mainz jedoch kaum statt. Der Tagungsbericht versucht, die Zugänge der unterschiedlichen Player nachzuzeichnen und deren versäumtes Gespräch zu rekonstruieren. Eine konzeptionelle und empirische Verbindung der Player scheint notwendig und sinnvoll. Der folgende Bericht kann bereits auf einige Forschungsprojekte aufmerksam machen, die eine solche Verknüpfung versuchen und auf dem Weg zu einer empirisch fundierten Bildungstheorie in Bildungsgangstudien die Eigenlogik pädagogischer Prozesse rekonstruieren und konstruktiv orientieren.

  5. Rudolf Streinz. Meinungs- und Informationsfreiheit zwischen Ost und West / Henn-Jüri Uibopuu

    Index Scriptorium Estoniae

    Uibopuu, Henn-Jüri, 1929-2012

    1983-01-01

    Tutvustus: Streinz, Rudolf. Meinungs- und Informationsfreiheit zwischen Ost und West : Möglichkeiten und Grenzen intersystemarer völkerrechtlicher Garantien in einem systemkonstituierenden Bereich. Ebelsbach : Rolf Gremer, 1981

  6. Renal, gastrointestinal, and hepatic late effects in survivors of childhood acute myeloid leukemia treated with chemotherapy only--a NOPHO-AML study

    DEFF Research Database (Denmark)

    Skou, Anne-Sofie; Glosli, Heidi; Jahnukainen, Kirsi; Jarfelt, Marianne; Jónmundsson, Guðmundur K; Malmros-Svennilson, Johan; Nysom, Karsten; Hasle, Henrik

    2014-01-01

    performed. Eighty-five of 94 (90%) eligible sibling controls completed a similar questionnaire. Siblings had no clinical examination or blood sampling performed. RESULTS: At a median of 11 years (range 4-25) after diagnosis, renal, gastrointestinal, and hepatic disorders were rare both in survivors of......BACKGROUND: We investigated the spectrum, frequency, and risk factors for renal, gastrointestinal, and hepatic late adverse effects in survivors of childhood acute myeloid leukemia (AML) without relapse treated with chemotherapy alone according to three consecutive AML trials by the Nordic Society...... childhood AML and in sibling controls, with no significant differences. Ferritin was elevated in 21 (21%) AML survivors but none had biochemical signs of liver damage. Viral hepatitis was present in three and cholelithiasis in two AML survivors. One adult survivor had hypertension, two had slightly elevated...

  7. Netzbasierte Dienste - Angebot, Nachfrage und Matching

    OpenAIRE

    Tamm, Gerrit

    2003-01-01

    Die vorliegende Dissertation präsentiert eine umfassende Analyse und Strukturierung des Marktes für netzbasierte Dienste. Basierend auf einer detaillierten Untersuchung des ASP-Angebotes und der ASP-Nachfrage in Europa werden geeignete Institutionen und Informationssubstitute für die Anpassung (Matching) des ASP-Angebotes und der ASP-Nachfrage identifiziert und getestet. Die Strukturierung der Angebotsseite umfasst neben der Bewertung der Marktlage die Entwicklung der ASP-Wertschöpfungskette...

  8. Zeitschriftenübersicht und Buchbesprechungen

    OpenAIRE

    1992-01-01

    Zeitschriftenübersicht und Buchbesprechungen: Schoppe, A. (1991): Kinderzeichnung und Lebenswelt. Neue Wege zum Verständnis des kindlichen Gestaltens. Herne. Affleck, G./ Tennen, H./Rowl, J. (1991). Infants in crisis. How parents cope with newborn intensive care and its aftermath. Berlin. Barchmann, H./Kinzl, W./Roth, N. (Hrsg) (1991). Aufmerksamkeit und Konzentration im Kindesalter. Berlin. Nissen, G. (Hrsg) (1991). Psychogene Psychosyndrome und ihre Therapie im Krndes- und J...

  9. Rohstoffe und Entwicklung : Entwicklung im Transnationalen Rohstoffrecht

    OpenAIRE

    Feichtner, Isabel

    2014-01-01

    Dieser Beitrag stellt das transnationale Rohstoffrecht und seine Entwicklung aus einer Konfliktperspektive dar und setzt es in Beziehung zu geopolitischen Transformationen und Wandlungen des Entwicklungsbegriffs. Sachlicher Gegenstand dieses Unterfangens sind erschöpfliche Vorkommen von Rohstoffen in Entwicklungsländern, ihre Ausbeutung und der Handel mit den gewonnenen Rohstoffen. Der Fokus liegt auf Mineralien, Öl und Gas. Der Text ist ein Versuch, Verantwortlichkeiten verschiedener Akteure...

  10. Kooperatives Lernen im Gruppenpuzzle und im Lernzirkel

    OpenAIRE

    Hänze, Martin; Berger, Roland

    2007-01-01

    Im Rahmen einer Unterrichtseinheit im Physikunterricht für 12. Klassen (insgesamt 282 Schüler und Schülerinnen) wurden die beiden kooperativen Lernformen Gruppenpuzzle und Lernzirkel hinsichtlich Lernergebnis, Unterrichtserleben und Variablen der Schülerkommunikation miteinander verglichen. Gruppenpuzzle und Lernzirkel unterscheiden sich hinsichtlich des Ausmaßes der Strukturierung, der Lehr-Erwartung, der Ressourceninterdependenz und der wechselseitigen Abhängigkeit der Schüler. Das Autonomi...

  11. Körpererfahrung, Bewegungs- und Bewusstseinsentwicklung

    OpenAIRE

    Grözinger, Helmut

    2009-01-01

    Die Arbeit diskutiert das notwendige symbiotische Miteinander von Schulmedizin und Biowissenschaft und den Menschenbildern traditioneller und integrierender Erkenntnislehren. Sie klärt dies an Vergleichen von Metasystemen, leib-soziologischen Ansätzen und bewusstseinserweiternden Verständnisbildern, dabei bezieht sie das aktuelle Wissen von Bioenergetik, Hirnforschung, organischer Kybernetik und Systemlehre mit ein. Gegenübergestellt wird die Komplementärerfahrung archaischer Bewusstseinsverf...

  12. Zur Relevanz wissenschafts-, medizin- und sozialgeschichtlicher Grundlagenforschung

    OpenAIRE

    Schmidt, Josef M.

    2013-01-01

    Aus Unkenntnis der eigenen methodischen Grundlagen und Beschränkungen überschreiten Wissenschaftler oft die legitimen Grenzen ihres Faches, wenn sie anderen Wissenschaften deren Wissenschaftlichkeit absprechen. Neue kritische Ansätze in den Natur-, Sozial- und Humanwissenschaften reflektieren hingegen vermehrt die Wechselwirkungen und Interdependenzen zwischen dem Forscher und seinem Fachgebiet bzw. dem Forschungsgegenstand und dem ihn selbst erst konstituierenden Rahmen. Aus der Wirtschaftsw...

  13. Sichere Aufbereitung von Transfer- und Lagerungshilfen

    OpenAIRE

    Graupner, Ilka; Sack, Andrea; Hübner, Nils-Olaf

    2012-01-01

    In der Pflege und Betreuung von pflegebedürftigen und behinderten Menschen werden zunehmend Transfer- und Lagerungshilfen (TLH) genutzt. Diese Hilfsmittel erfüllen eine Dreifachfunktion, da sie die Eigenaktivität und Mobilität der Pflegebedürftigen unterstützen, die Dekubitusprophylaxe verbessern und den pflegerischen Umgang mit den Patienten erleichtern. Dadurch kann auch die körperliche Belastung für das Pflegepersonal verringert werden. Obwohl von vielen Herstellern die Anwendun...

  14. Gender- und Diversity-Management in der Forschung: Stuttgart, 7. und 8. Mai 2015, Konferenzband

    OpenAIRE

    Klemisch, Michaela; Spitzley, Anne; Wilke, Jürgen

    2015-01-01

    Chancengleichheit ist in Zeiten des demografischen Wandels sowie des zunehmenden Fachkräftemangels ein Schlüsselfaktor für den wirtschaftlichen Erfolg von Unternehmen und für die wissenschaftliche Arbeit in Forschungsabteilungen. Wie kann die Chancengleichheit von Frauen und Männern in der Forschung und in Unternehmen gelebt werden? Warum stellt Gender- und Diversity-Management einen strategisch wichtigen Erfolgsfaktor dar? Und wie kann Chancengleichheit in der wissenschaftlichen und industri...

  15. Tagungsessay: Innen und Außen in Wissenssoziologie und Diskursanalyse

    OpenAIRE

    Fein, Elke; Florea, Marie-Laure

    2007-01-01

    Der vorliegende Bericht bilanziert einige der zentralen Thesen und Diskussionen des im Sommer 2005 in Paris abgehaltenen deutsch-französischen Kolloquiums zu Stand und Perspektiven der Diskursforschung in Deutschland und Frankreich. In Frankreich geht die Diskursanalyse auf die strukturalistische Theoriebildung zurück, wie sie seit SAUSSURE im Kontext linguistischer Diskussionszusammenhänge entstand und von Theoretikern wie FOUCAULT, DERRIDA, ALTHUSSER und LACAN konkretisiert und fortgeschrie...

  16. Grundlegende Untersuchungen zum Strangpressen von Magnesiumblechen und deren Weiterverarbeitung: Mikrostruktur und mechanische Eigenschaften

    OpenAIRE

    Gall, Sven

    2013-01-01

    Das Strangpressen von Magnesiumblechen besitzt den Vorteil, in einem einzigen Prozessschritt sehr geringe Blechdicken herstellen zu können und stellt somit eine Alternative zum Walzen und Gießwalzen dar. Für eine wirtschaftliche Nutzung und Weiterverarbeitung von stranggepressten Magnesiumblechen ist jedoch die genaue Kenntnis des Einflusses der Herstellungsparameter des Strangpressens und nachgelagerter Prozesse wie Walzen und Wärmebehandlung auf die Mikrostruktur und damit auf die mechanisc...

  17. [Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Letgallen. Stadt, Land und Konfession 1500-1721. 2. und 3. Teil] / Anti Selart

    Index Scriptorium Estoniae

    Selart, Anti, 1973-

    2012-01-01

    Arvustus: Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Letgallen. Stadt, Land und Konfession 1500-1721. Hrsg. von Matthias Asche, Werner Buchholz, Anton Schindling. 2. und 3. Teil.

  18. Heide von Felden: Bildung und Geschlecht zwischen Moderne und Postmoderne. Zur Verknüpfung von Bildungs-, Biographie- und Genderforschung. Opladen: Leske + Budrich 2003 (Band 21 der Reihe: Studien zu Erziehungswissenschaft und Bildungsforschung) [Rezension

    OpenAIRE

    Bönold, Fritjof

    2005-01-01

    Rezension zu: Heide von Felden: Bildung und Geschlecht zwischen Moderne und Postmoderne. Zur Verknüpfung von Bildungs-, Biographie- und Genderforschung. Opladen: Leske + Budrich 2003 (Band 21 der Reihe: Studien zu Erziehungswissenschaft und Bildungsforschung)

  19. Low-dose total body irradiation and G-CSF without hematopoietic stem cell support in the treatment of relapsed or refractory acute myelogenous leukemia (AML), or AML in second or subsequent remission

    International Nuclear Information System (INIS)

    Purpose: Patients with relapsed acute myelogenous leukemia (AML), who are not eligible for bone marrow transplantation, have a poor prognosis when treated with chemotherapy alone. Total body irradiation (TBI) is an effective modality against AML when used in doses of 1000-1400 cGy with hematopoietic stem cell support. We undertook a phase I study of TBI with granulocyte-colony-stimulating factor (G-CSF) support, without stem cell support in patients with AML either in relapse or second or subsequent remission. Methods and Materials: Patients with relapsed AML, or AML in second or subsequent remission were treated in a phase I study of TBI followed by G-CSF. The first dose level was 200 cGy. After the initial cohort of patients it was clear that patients with overt leukemia did not benefit from this treatment, and subsequent patients were required to be in remission at the time of TBI. Results: Eleven patients were treated, 4 in overt relapse, and 7 in remission. 200 cGy was used in all, and dose escalation was not possible due to prolonged thrombocytopenia in all patients but one. Neutrophil recovery was adequate in those patients who remained in remission after TBI. Patients with overt leukemia had transient reduction in blast counts, but rapid recurrence of their leukemia. Patients treated in remission had short remissions, with the exception of one patient who is in remission 32 months after treatment. Conclusion: There is some antileukemic effect of TBI even at 200 cGy, though this dose appears to be too low to help a significant number of patients. If TBI is to be escalated without stem cell support, then a thrombopoietic agent will need to be used

  20. MDS-RA MgA与M6的骨髓细胞形态学鉴别分析

    Institute of Scientific and Technical Information of China (English)

    李蓉

    2012-01-01

    目的 分析骨髓增生异常综合征难治性贫血(MDS-RA)、巨幼细胞性贫血(MgA)及急性红白血病(M6)患者骨髓细胞形态特点,提高这三种血液病的诊断与鉴别水平.方法 对在我院及上海长海医院确诊的35例MDS-RA、MgA及M6患者的骨髓细胞形态进行回顾性分析.结果 MDS-RA骨髓增生活跃或明显活跃,有少数增生减低,粒红比常减低,多见两系以上病态;MgA骨髓增生明显活跃,粒红比常减低,粒红两系出现巨幼样变;M6骨髓增生明显活跃,粒红比常倒置,红系明显病态,原始细胞明显增多.结论 MDS-RA、MgA及M6的骨髓共同点:都会出现红系明显增生,出现巨幼样病态改变.不同点:MDS-RA 与M6主要是以各系病态造血明显,通常以原始细胞比例不同进行鉴别,MgA主要表现为各系以巨幼样变为特征,且原始细胞比例不高.

  1. A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction

    DEFF Research Database (Denmark)

    Burnett, A. K.; Russell, N. H.; Hills, R. K.;

    2015-01-01

    Modifying induction therapy in acute myeloid leukemia (AML) may improve the remission rate and reduce the risk of relapse, thereby improving survival. Escalation of the daunorubicin dose to 90 mg/m(2) has shown benefit for some patient subgroups when compared with a dose of 45 mg/m(2), and has be...

  2. Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML

    DEFF Research Database (Denmark)

    Rapin, N; Porse, B T

    2014-01-01

    Reciprocal chromosomal translocations are observed in one-third of acute myeloid leukemia (AML) cases. Targeting and understanding the effects of the resulting aberrant oncogenic fusion proteins may help developing drugs against specific leukemic subtypes, as demonstrated earlier by the use of ATRA...

  3. Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML.

    Science.gov (United States)

    Volk, Andrew; Li, Jing; Xin, Junping; You, Dewen; Zhang, Jun; Liu, Xinli; Xiao, Yechen; Breslin, Peter; Li, Zejuan; Wei, Wei; Schmidt, Rachel; Li, Xingyu; Zhang, Zhou; Kuo, Paul C; Nand, Sucha; Zhang, Jianke; Chen, Jianjun; Zhang, Jiwang

    2014-06-01

    Leukemic stem cells (LSCs) isolated from acute myeloid leukemia (AML) patients are more sensitive to nuclear factor κB (NF-κB) inhibition-induced cell death when compared with hematopoietic stem and progenitor cells (HSPCs) in in vitro culture. However, inadequate anti-leukemic activity of NF-κB inhibition in vivo suggests the presence of additional survival/proliferative signals that can compensate for NF-κB inhibition. AML subtypes M3, M4, and M5 cells produce endogenous tumor necrosis factor α (TNF). Although stimulating HSPC with TNF promotes necroptosis and apoptosis, similar treatment with AML cells (leukemic cells, LCs) results in an increase in survival and proliferation. We determined that TNF stimulation drives the JNK-AP1 pathway in a manner parallel to NF-κB, leading to the up-regulation of anti-apoptotic genes in LC. We found that we can significantly sensitize LC to NF-κB inhibitor treatment by blocking the TNF-JNK-AP1 signaling pathway. Our data suggest that co-inhibition of both TNF-JNK-AP1 and NF-κB signals may provide a more comprehensive treatment paradigm for AML patients with TNF-expressing LC. PMID:24842373

  4. Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML

    Science.gov (United States)

    Volk, Andrew; Li, Jing; Xin, Junping; You, Dewen; Zhang, Jun; Liu, Xinli; Xiao, Yechen; Breslin, Peter; Li, Zejuan; Wei, Wei; Schmidt, Rachel; Li, Xingyu; Zhang, Zhou; Kuo, Paul C.; Nand, Sucha; Zhang, Jianke; Chen, Jianjun

    2014-01-01

    Leukemic stem cells (LSCs) isolated from acute myeloid leukemia (AML) patients are more sensitive to nuclear factor κB (NF-κB) inhibition-induced cell death when compared with hematopoietic stem and progenitor cells (HSPCs) in in vitro culture. However, inadequate anti-leukemic activity of NF-κB inhibition in vivo suggests the presence of additional survival/proliferative signals that can compensate for NF-κB inhibition. AML subtypes M3, M4, and M5 cells produce endogenous tumor necrosis factor α (TNF). Although stimulating HSPC with TNF promotes necroptosis and apoptosis, similar treatment with AML cells (leukemic cells, LCs) results in an increase in survival and proliferation. We determined that TNF stimulation drives the JNK–AP1 pathway in a manner parallel to NF-κB, leading to the up-regulation of anti-apoptotic genes in LC. We found that we can significantly sensitize LC to NF-κB inhibitor treatment by blocking the TNF–JNK–AP1 signaling pathway. Our data suggest that co-inhibition of both TNF–JNK–AP1 and NF-κB signals may provide a more comprehensive treatment paradigm for AML patients with TNF-expressing LC. PMID:24842373

  5. Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation

    DEFF Research Database (Denmark)

    Schmid, Christoph; Labopin, Myriam; Nagler, Arnon; Niederwieser, Dietger; Castagna, Luca; Tabrizi, Reza; Stadler, Michael; Kuball, Jürgen; Cornelissen, Jan; Vorlicek, Jiri; Socié, Gerard; Falda, Michele; Vindeløv, Lars; Ljungman, Per; Jackson, Graham; Kröger, Nicolaus; Rank, Andreas; Polge, Emmanuelle; Rocha, Vanderson; Mohty, Mohamad

    2012-01-01

    Since information on management and outcome of adults with AML relapsing after allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning (RIC HSCT) is scarce, a retrospective registry study was performed by the Acute Leukemia Working Party of EBMT. Among 2815 RIC...

  6. 30 CFR 872.20 - What will OSM do with unappropriated AML funds currently allocated to the Rural Abandoned Mine...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false What will OSM do with unappropriated AML funds currently allocated to the Rural Abandoned Mine Program ? 872.20 Section 872.20 Mineral Resources OFFICE OF... MONEYS AVAILABLE TO ELIGIBLE STATES AND INDIAN TRIBES § 872.20 What will OSM do with unappropriated...

  7. High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity.

    Science.gov (United States)

    Lynn, R C; Feng, Y; Schutsky, K; Poussin, M; Kalota, A; Dimitrov, D S; Powell, D J

    2016-06-01

    Acute myeloid leukemia (AML) is an aggressive malignancy, and development of new treatments to prolong remissions is warranted. Chimeric antigen receptor (CAR) T-cell therapies appear promising but on-target, off-tumor recognition of antigen in healthy tissues remains a concern. Here we isolated a high-affinity (HA) folate receptor beta (FRβ)-specific single-chain variable fragment (2.48 nm KD) for optimization of FRβ-redirected CAR T-cell therapy for AML. T cells stably expressing the HA-FRβ CAR exhibited greatly enhanced antitumor activity against FRβ(+) AML in vitro and in vivo compared with a low-affinity FRβ CAR (54.3 nm KD). Using the HA-FRβ immunoglobulin G, FRβ expression was detectable in myeloid-lineage hematopoietic cells; however, expression in CD34(+) hematopoietic stem cells (HSCs) was nearly undetectable. Accordingly, HA-FRβ CAR T cells lysed mature CD14(+) monocytes, while HSC colony formation was unaffected. Because of the potential for elimination of mature myeloid lineage, mRNA CAR electroporation for transient CAR expression was evaluated. mRNA-electroporated HA-FRβ CAR T cells retained effective antitumor activity in vitro and in vivo. Together, our results highlight the importance of antibody affinity in target protein detection and CAR development and suggest that transient delivery of potent HA-FRβ CAR T cells is highly effective against AML and reduces the risk for long-term myeloid toxicity. PMID:26898190

  8. Zustand und Entwicklung von Seen in Berlin und Brandenburg

    OpenAIRE

    Michael Hupfer; Brigitte Nixdorf

    2011-01-01

    In diesem Beitrag sollen ausgewählte Aspekte der Entwicklung von Seen in Berlin-Brandenburg im Zusammenhang mit den prognostizierten Klimaänderungen dargestellt werden. Dazu wird zunächst ein Überblick zur Entstehung und Typisierung von Gewässern sowie ihrer Nutzung gegeben. Anhand des aktuellen Wissens wird diskutiert, welche Konsequenzen sich aus den erwarteten Veränderungen der Temperatur und des hydrologischen Regimes auf die Funktion und Nutzung vor allem von Seen in Berlin-Brandenburg e...

  9. Mitogenic and Cytotoxic Effects of Pentachlorophenol to AML 12 Mouse Hepatocytes

    Directory of Open Access Journals (Sweden)

    Dwayne Sutton

    2004-09-01

    Full Text Available Pentachlorophenol (PCP, an organochlorine fungicide, is extensively used in the United States for the protection of wood products. Moreover, widespread agricultural, domestic, and industrial applications have caused PCP-contaminants to enter the food chain from the environment. There is accumulating evidence indicating that PCP is highly toxic to humans, and causes injury to major organs including the lung, liver, kidneys, heart, and brain. While PCP has been shown to induce systemic toxicity and carcinogenesis in several experimental studies, the literature is scarce regarding its toxic mechanisms of action. Recent investigations in our laboratory have shown that PCP exerts both cytotoxic and mitogenic effects in human liver carcinoma (HepG2 cells [1], and in primary culture of catfish hepatocytes [2]. In the present study, we hypothesized that PCP exposure will trigger similar cytotoxic and mitogenic responses in AML 12 Mouse hepatocytes. To test this hypothesis, we performed the MTT assay for cell viability in PCP-treated and control cells. Data obtained from this experiment indicated a biphasic response with respect to PCP toxicity; showing a hormosis effect characterized by mitogenicity at lower levels of exposure, and cytotoxicity at higher doses. Upon 48 hrs of exposure, PCP chemical doses required to cause 50% reduction in the viability (LC50 of AML 12 mouse hepatocytes was computed to be 16.0 + 2.0 μg/mL. These results indicate that, although the sensitivity to PCP toxicity varies from one cell line to another, its toxic mechanisms are similar across cell lines.

  10. Targeting MDR1-P-glycoprotein (MDR1-Pgp in immunochemotherapy of acute myeloid leukemia (AML

    Directory of Open Access Journals (Sweden)

    Maurizio Cianfriglia

    2013-06-01

    Full Text Available BACKGROUND: Monoclonal antibodies represent the fastest growing sector of pharmaceutical biotechnology and a number of antibody-based biopharmaceuticals have been approved for cancer treatment. However, in many cases the antibodies used for the treatment of tumors offer only a modest survival benefit to cancer patients. AIMS: In the present review-article we intend to analyze: i the curative regimen gemtuzumab ozogamicin (GO -mediate characterized by the absence of cytotoxic drugs MDR1-Pgp substrates to overcome the mechanism of action of this multidrug transporter, ii the safety and efficacy of MDR reversing strategy in AML outcome and, iii chemical and biological MDR modulators playing a dual relevant medical role as a therapeutic and MDR reversing agents but not yet entered in the clinical setting of AML. Since the similar multidrug transporter protein MDR1-Pgp and its down modulation factors may affect safety and efficacy of already generated antibody drug conjugates (ADCs a comprehensive overview of the most clinically representative immunoconjugates is reported. DISCUSSION: ADCs represent one of the most promising strategies to enhance the antitumor activity of antibodies. ADCs comprise an antibody (or an antibody fragment conjugated to a cytotoxic drug via a chemical linker. The therapeutic concept of ADCs is to use an antibody as a vehicle to selectively delivering a cytotoxic drug specifically to a tumor cell, in most cases by means of binding to target cell surface antigen. As a consequence, ADCs have significant potential for enhancing the antitumor activity of "naked" antibodies and reducing the systemic toxicity of the conjugated drugs.

  11. Angiomyolipoma (AML) without visible fat: Ultrasound, CT and MR imaging features with pathological correlation

    International Nuclear Information System (INIS)

    To compare imaging findings with histopathology in AML without visible fat (AMLwvf). With IRB approval, we identified 18 AMLwvf that underwent CT between 2002-2014. A radiologist measured NECT-attenuation, corticomedullary (CM) and nephrographic (NG) enhancement, echogenicity relative to renal cortex (RC) (N = 5), T2W (T2AML/T2RC) signal-intensity (SI), and chemical-shift SI ([SIIN-PHASE - SIOPPOSED-PHASE]/SIIN-PHASE) indices (N = 6). A pathologist re-evaluated 15/18 AMLwvf for 1) < or > 25 % adipocytes/high-power-field (HPF), 2) ''many or few'' blood vessels. Comparisons were performed using chi-square and independent t-tests. 73.3 %(11/15) of AMLwvf had <25 % adipocytes/HPF and 86.7 %(13/15) had ''many'' blood vessels. NECT-attenuation was 41.8(±6.9) HU. 61.1 %(11/18) of AMLwvf were hyper-attenuating and 38.9 %(7/18) iso-attenuating; attenuation was associated with %-adipocytes/HPF, (p = 0.01). CM/NG enhancement were 63.3(±20.8)/51.7(±15.5) HU. 72.2 %(13/18) of AMLwvf had wash-out enhancement, with no association with amount of blood vessels at pathology, (p = 0.68). No difference in echogenicity was noted by histology (p > 0.05). All AMLwvf were T2-hypointense (SI ratio = 0.61 [±0.1]). 2/6 AMLwvf showed SI drop on chemical-shift MRI; both were iso-attenuating and were associated with >25 % adipocytes/HPF (p = 0.04). AMLwvf are typically T2-hypointense and hyper-attenuating with wash-out enhancement due to abundant smooth muscle and vessels respectively. Iso-attenuating AMLwvf with microscopic fat on MRI contain more adipocytes/HPF. (orig.)

  12. Dinge und Eigenschaften

    OpenAIRE

    Wachter, Daniel von

    2000-01-01

    Dieses Buch ist ein Beitrag zur zeitgenössischen Diskussion über das Universa-lienproblem. Es eignet sich auch zur Einführung in die Ontologie. Kap. 1: Darstellung der Ontologie David Armstrongs. Kap. 2: Rekonstruktion der Ontologie des polnischen Husser-Schülers und Phänomenologen Roman Ingarden. Kap. 3: Kritik am Universalienrealismus. Die Schwierigkeit liegt weniger in der Annahme von Universalien als in der Annahme von Substraten. Kap. 4: Die „Feldontologie“ wird entwickelt,...

  13. Zwischen Evolutionskritik und Atheismus

    OpenAIRE

    Engelbert Recktenwald

    2014-01-01

    Thomas Nagel kritisiert den Reduktionismus und Darwinismus, bekennt sich aber gleichzeitig zum Atheismus. Sein zentrales Argument gegen den Gottesgedanken ist seine Auffassung von der Intelligibilität der Welt, das auch in seiner Kritik am Darwinismus eine große Rolle spielt. Er sieht die göttliche Freiheit als eine Bedrohung dieser Intelligibilität. Was ist davon zu halten?Between a criticism of evolution and atheism Thomas Nagel criticizes reductionism and Darwinism, but at the same time he...

  14. Sichere und effiziente Benutzerverwaltung

    OpenAIRE

    Meyer, Harald

    2006-01-01

    Ein zentrales Identitätsmanagement erleichtert die Verwaltung der IT-Zugänge unterschiedlicher Benutzergruppen innerhalb einer Organisation. Sobald jedoch auch Zugänge für Benutzer außerhalb der eigenen Organisation verwaltet werden müssen , stößt ein zentrales Konzept schnell an organisatorische Grenzen. Föderation ist ein Ansatz, um dieses Problem zu lösen, indem ein sicherer und trotzdem effizient zu verwaltender Zugang für externe Benutzer ermöglicht wird. In der Praxis haben sich mit Lib...

  15. 10. Umwelt und Entwicklung

    OpenAIRE

    Tschumi Canosa, Xavier

    2010-01-01

    Zweifellos war 2007 das Jahr, in dem der Klimawandel Eingang ins Bewusstsein der Öffentlichkeit fand. Die von der Zwischenstaatlichen Sachverständigengruppe für Klimaänderungen (International Panel on Climate Change, IPCC) veröffentlichten Berichte über die klimatischen Veränderungen, die als Referenz auf diesem Gebiet gelten, bestätigen, dass der Klimawandel überwiegend menschenverursacht ist. Die Verleihung des Friedensnobelpreises 2007 an Rajendra Pachauri, den Vorsitzenden der IPCC, und a...

  16. GROSSSPRENGUN UND MIKROSEISMIK

    Directory of Open Access Journals (Sweden)

    E. HARDTWIG

    1956-06-01

    Full Text Available Uéber die bei Sprengungen entstelienden Periodenspektren ist noch
    wenig bekannt, trotzdem in jedem Jahre Tausende von Sprengungen
    registriert werden. Die wenigen Arbeiten, die zu diesem Gegenstand erscliienen
    sind, stellen nur erste Versuche dar, den Aufbau der Spektren
    zu erklaren. Wàhrend etwa George Morris (* vorwiegend die bei
    Sprengungen si eh abspielenden Detonationsvorgànge zum Ausgangspunkt
    der Untersuchung macht, ist es bei IT. Menzel (2 die Interferenz von
    Primàrwelle und reflektierter Welle, deren Einfluss auf die Gestalt
    des Spektrums untersucht wird.

  17. [Correlation of adult AML Npm1 mutations with prognosis and its relationship with gene mutation of FLT3 and CEBPA].

    Science.gov (United States)

    Bao, Li-Yan; Wang, Ji-Shi

    2010-02-01

    This study was aimed to investigate the correlation of 12th exon mutations in the npm1 gene with prognosis of adult AML patients and to explore the relationship of 12th exon mutation with other gene mutations. The specimen of bone marrow and peripheral blood from AML patients, the informations of medical history, symptoms, related image examinations, blood routine examination, NAP, oxygen saturation level in artery blood and EPO level in serum were collected; the bcr/abl fusion gene was detected by routine examination of bone marrow + biopsy + chromosome mapping + FISH. The patients were typed according to WHO classification. The DNA in cells was extracted, the npm1 gene mutation was detected by allele specific PCR combined were the sequencing. The results indicated that the npm1 heterozygote gene mutation was found in 72 out of 150 AML patients with normal cytogenetics (48%, 72/150). 48% patients showed a frameshift mutation in the C-terminal region of the NPM1 protein. The AML patients with npm1 gene mutation had specific clinical, phenotypic and genetic characteristics. The statistical analysis demonstrated the relationship between npm1 and flt3 ITDs. The patients with npm1 mutation showed a better response to induction therapy, furthermore, the overall survival (OS) rate of patients without flt3 ITD mutation was enhanced. The multivariate analysis demonstrated that the npm1 gene mutation and cebpa mutation positively correlated to the OS rate, and the correlation of flt3 mutation to OS rate showed negative. It is concluded that npm1 mutation is a favorable independent prognostic factor for adult AML patients with normal cytogenetics under conditions without FIT3 gene mutation. PMID:20137111

  18. A new model to predict remission status in AML patients based on day 14 bone marrow biopsy.

    Science.gov (United States)

    Norkin, Maxim; Chang, Myron; An, Qi; Leather, Helen; Katragadda, Lakshmikanth; Li, Ying; Moreb, Jan S; May, W Stratford; Brown, Randy A; Hsu, Jack W; Hiemenz, John W; Wingard, John R; Cogle, Christopher R

    2016-07-01

    Although bone marrow evaluation on day 14 after initiation of induction chemotherapy (D14 BM) is a widely accepted practice in patients with acute myeloid leukemia (AML), it has suboptimal predictive value for predicting complete remission. We retrospectively analyzed pretreatment characteristics and post-induction response in a cohort of AML patients to determine if adding clinical and laboratory characteristics can improve the predictive value of the D14 BM evaluation. Among 297 patients treated for AML at the single institution 183 patients (61%) had leukemia-positive D14 BM. Of those, 94 were given reinduction chemotherapy and 89 were not. Of the 89 patients who did not receive reinduction, 32 (36%) subsequently achieved complete remission (CR) or complete remission with incomplete count recovery (CRi), and 57 (64%) had persistent disease. Persistent disease after positive D14 BM was more likely associated with higher percentage of D14 myeloblasts, a history of relapsed disease before induction, and higher risk disease compared to patients who subsequently achieved CR. Age, diagnostic white blood cell count, and the D14 BM cellularity did not influence the subsequent likelihood of achieving remission in patients with a positive D14 BM. A new mathematical equation was created and resulted in a positive predictive value of 83%, negative predictive value 90% and accuracy 88% for correctly identifying remission status after positive D14 BM in AML. The accuracy of predicting response using these additional parameters was significantly higher than without (0.88 vs. 0.80, P=0.002). Our new model provides better accuracy for predicting the likelihood of achieving remission and if validated in future studies may be useful for managing AML patients. PMID:27132034

  19. Editorial: Informationstechnische Bildung und Medienerziehung

    Directory of Open Access Journals (Sweden)

    Annemarie Hauf-Tulodziecki

    2001-10-01

    Full Text Available Die schulische Medienerziehung bzw. die Medienbildung hat ihre derzeit hohe öffentliche Aufmerksamkeit nicht zuletzt der Tatsache zu verdanken, dass gerade die so genannten «Neuen Medien» - heute oft mit den Schlagworten «Multimedia» oder «Internet» abgekürzt - wichtige Erziehungs- und Bildungsmassnahmen erforderlich machen. In der öffentlichen Diskussion gehören inhaltliche Kurzschlüsse zur Tagesordnung: Wenn von «Medienkompetenz» die Rede ist, verbirgt sich dahinter häufig nur ein «Internetführerschein». Diese Beobachtung ärgert nicht nur Medienpädagogen, sondern auch Vertreter einer Informationstechnischen Bildung (1, da berechtigte pädagogische Ansprüche beider Gruppen wenig Beachtung finden. Mittlerweile gibt es eine Reihe von Empfehlungen von BLK und KMK zu diesem Thema, in denen zudem deutlich auf die wechselseitigen Bezüge hingewiesen werden. Die wachsende Bedeutung des Mediums Computer und die weiter zunehmende Digitalisierung traditioneller Medien erfordert sowohl für die Medienerziehung als auch für die Informatische Bildung eine Weiterentwicklung ihrer Ziele und Inhalte. Die Gesellschaft für Informatik e.V. hat 1999 in ihrer Empfehlung «Informatische Bildung und Medienerziehung» aus ihrer Perspektive dargestellt, welche Aufgaben auf die Medienerziehung zukommen, wenn auch die Informations- und Kommunikationstechnologien bzw. die computerbasierten Medien in einer angemessenen Form thematisiert werden sollen. Erste praktische Ansätze, Inhalte aus beiden Bereichen bewusst zusammenzuführen, auch unter einer gemeinsamen Fach- oder Kursbezeichnung, sind häufig additiv und orientieren sich – trotz vorhandener Überschneidungen – an den etablierten medienpädagogischen oder an den informatischen Unterrichtsprinzipien. In dem vorliegenden Themenheft wird aus einer übergeordneten, medienpädagogischen Perspektive die Frage gestellt, wie eine konsistente Weiterentwicklung der Medienerziehung unter angemessener

  20. Implantation und Komplikation der Vagusnervstimulation

    Directory of Open Access Journals (Sweden)

    Spuck S

    2007-01-01

    Full Text Available Weltweit wurden bis zum Beginn des Jahres 2007 45.000 Vagusnervstimulatoren (VNS implantiert. Trotz der häufigen Operationen sind nur wenige Berichte über Komplikationen veröffentlicht. Die primäre operative Implantation ist ein sicheres Verfahren. Komplikationen und Nebenwirkungen können nach operations-, material- und stimulationsassoziiertem Ursprung unterteilt werden. Erforderliche Revisionseingriffe sind insbesondere bei Kindern anspruchsvoll. Im folgenden Artikel werden mögliche Probleme der VNS-Therapie und deren Behandlung dargestellt.