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Sample records for aminonaphthoquinone mannich bases

  1. Novel aminonaphthoquinone mannich bases derived from lawsone and their copper(II) complexes: synthesis, characterization and antibacterial activity

    Energy Technology Data Exchange (ETDEWEB)

    Neves, Amanda P.; Barbosa, Claudia C.; Greco, Sandro J.; Vargas, Maria D. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Quimica; Visentin, Lorenzo C. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica; Pinheiro, Carlos B. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Fisica; Mangrich, Antonio S. [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Centro Politecnico. Dept. de Quimica; Barbosa, Jussara P.; Costa, Gisela L. da [Instituto Oswaldo Cruz, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    A series of novel Mannich bases (HL1-HL13) derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes [C{sub 6}H{sub 2}R{sup 1}R{sup 2}R{sup 3}C(O)H] and various primary amines (NH{sub 2}R{sup 4}, R{sup 4} = n-butyl, benzyl, allyl, 2-furfuryl), and their Cu{sup 2+} complexes, [Cu(L1){sub 2}]-[Cu(L13){sub 2}], have been synthesized and fully characterized by analytical and spectroscopic methods. The structures of complexes 1 (R{sup 1} R{sup 2} = R{sup 3} = H; R{sup 4} = Bu), 2 (R{sup 1} = R{sup 3} = H; R{sup 2} = NO{sub 2}; R{sup 4}= Bu) and 7 (R{sup 1} OH; R{sup 2} = R{sup 3} = H; R{sup 4}= Bu) were determined by single crystal X-ray diffraction studies. All complexes crystallize in centrosymmetric space groups, with a copper atom in the inversion centre. Two L. coordinate through the naphthalen-2-olate oxygen and secondary amine-N atoms, forming six membered chelate rings around the copper atom in a trans-N{sub 2}O{sub 2} environment; spectroscopic data confirm that the other complexes exhibit similar molecular arrangement. The antimicrobial activity of all compounds has been tested on seven different strains of bacteria: Bacillus cereus, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. In general, Mannich bases were more active than complexes, HL11 (R{sup 1} = OH; R{sup 2} =H; R{sup 3} = Me; R{sup 4}= Bn) and HL13 (R{sup 1} = OH; R{sup 2} = H; R{sup 3} = Br; R{sup 4}= Bn) being the most potent inhibitors. The MIC for the most active compound HL11 against S. Coli was 20 {mu}mol L{sup -1} (8 {mu}g mL{sup -1}), better than Chloramphenicol (90 {mu}mol L{sup -1}) and well below most values reported for other naphthoquinones. (author)

  2. Mannich Bases: An Important Pharmacophore in Present Scenario

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    Suman Bala

    2014-01-01

    Full Text Available Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to α, β-unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group.

  3. Biosynthesis of some Mannich bases

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    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The Mannich reaction is extremely useful to form molecules that contain nitrogen groups. Currently, there is a great interest turned to this class of compounds due to its biological properties. The recent literature reports that the utilization of enzymes can be an adequate methodology on this type of reaction. According to the exposed above and with the intention of synthesizing the -aminoketones, some catalysts like Chymosin and also some microorganisms such as Saccharomyces cerevisiae, (sourdough bread and Lactobacilos (ATCC 90827LA10N19.10-E.U.A were applied. These reactions were carried out by using water as solvent at room temperature excelling for the Green Chemistry principles. Figure 1 shows the reaction scheme involving 1 eq.mol of aniline, 1,3 eq.mol of formaldehyde, 10 ml of water and 0,25g of the catalyst during four days. The reaction furnished satisfactory yields which are in accordance with the literature data.

  4. Stereoselective bioreduction of someMannich bases

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    Bruna S. D. R. Aranha

    2012-06-01

    Full Text Available The chemic reaction that happen on the live organism (plants, superior animals and microorganisms produce various chiral substances such as pheromones, antibiotics and others. After the eighties, with the break of the dogma referent to the enzymatic utilization only in aqueous medias, diverse enzyme application were revealed in other reaction medias, what allowed new studies turned to enzymatic application in organic chemistry. Such studies revealed that these biocatalysts presented high selectivity in these medias, no only about to the chemoselectivity but especially to the enantioselectivity. According to what was exposed, this work aimed to execute the bioreduction of some Mannich bases using the microorganism Saccharomyces cerevisiae (sourdough bread. Scheme 1 shows the reaction scheme involving 1 eq.mol of the b-aminocarbonilated product, 10 mL of   the suitable solvent and 0,5g of the biocatalys during four days at room temperature. These reactions presented satisfactory yields, which are in accordance with the literature.

  5. Green chemistry approach to the synthesis of potentially bioactive aminobenzylated Mannich bases through active hydrogen compounds

    OpenAIRE

    S. L. VASOYA; P. T. CHOVATIA; D. H. PUROHIT; H. S. JOSHI

    2005-01-01

    An efficient and high yield method for the synthesis of aminobenzylated Mannich bases is described. The synthesis occurs in aqueous medium at 0 ºC. The compounds show moderate antitubercular and antimicrobial activities.

  6. Green chemistry approach to the synthesis of potentially bioactive aminobenzylated Mannich bases through active hydrogen compounds

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    S. L. VASOYA

    2005-10-01

    Full Text Available An efficient and high yield method for the synthesis of aminobenzylated Mannich bases is described. The synthesis occurs in aqueous medium at 0 ºC. The compounds show moderate antitubercular and antimicrobial activities.

  7. Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

    Institute of Scientific and Technical Information of China (English)

    Jiao Wang; Ying Zhong; Lu Liu; Xin Quan Ji; Zhi Guo Zhang

    2008-01-01

    Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide (NO) production inhibitory activity was evaluated.Compounds 2a,2b,2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.

  8. Trimerization catalysis of phenylisocyanate in the presence of phenolic mannich bases

    Energy Technology Data Exchange (ETDEWEB)

    Selivanov, A.V.; Zenitova, L.A.; Bakirova, I.N.; Kirpichnikov, P.A.

    1988-11-01

    The kinetics of the cyclic trimerization of phenylisocyanate in the presence of phenolic Mannich bases have been studied by IR spectroscopy; a catalysis mechanism for the reaction is proposed. It was found that in order for trimerization to occur the catalyst molecule must contain both a hydroxyl group and a tertiary nitrogen atom, which leads to reaction at the OH group of the catalyst and its conversion via a urethane derivative to an allophanate; the latter species undergoes tautomeric rearrangement to a bipolar ion, which is the actual catalysis site. The effects of the number of aminomethyl, hydroxyl, and other electron-donating and electron-withdrawing substituents on the structure of Mannich bases have also been investigated.

  9. Synthesis, Characterization and Biological Evaluation of 1, 2-Disubstituted Benzimidazole Derivatives using Mannich Bases

    OpenAIRE

    Reddy, B. Anil

    2010-01-01

    The ring system in which a benzene ring is fused to the 4,5-positions of imidazole is designated as benzimidazole. Condensations of 2-substituted benzimidazole derivatives were synthesized by different carboxylic acids using Mannich base and anti-inflammatory activity. The various positions on the benzimidazole ring are numbered in the manner indicated with the imino function as number one. The formations of the product were conformed by the analytical and spectral data.

  10. Novel Mannich bases bearing pyrazolone moiety. Synthesis, characterization and electrochemical studies

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    KRISHNA NAIK

    2013-04-01

    Full Text Available The present investigation describes a series of new {4-[3-Methyl-5-oxo-4-(4|-substituted phenyl hydrazono-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid (2-oxo-1-piperidine-1-ylmethyl-1,2-dihydro–indol-3-ylidene-hydrazides synthesized by the Mannich reaction of {4-[3-Methyl-5-oxo-4-(4|-substituted phenyl hydrazono-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid (2-oxo-1,2-dihydro-indol-3-ylidene-hydrazide with aqueous formaldehyde and a solution of piperidine in dimethylformamide. These novel Mannich bases were characterized by elemental analysis, IR, 1H NMR and mass spectral data. Electrochemical behavior of these compounds were studied by two techniques namely polarography and cyclic voltammetry. The results from both the techniques were compared and the reduction mechanism in acidic as well as basic medium was proposed.

  11. Structural studies on Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene. An UV, IR, NMR and DFT study. A mini-review

    DEFF Research Database (Denmark)

    Hansen, Poul Erik; Spanget-Larsen, Jens

    2016-01-01

    Mannich bases of 2-Hydroxy-3,4,5,6-tetrachlorobenzene are chosen as an exemplary case for tautomeric Mannich bases. Molecular structures are calculated. OH stretching frequencies are rationalized based on DFT calculations. Intrinsic deuterium isotope effects on 13C chemical shifts in the M-form a...

  12. Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

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    Surendra N. Pandeya

    2012-01-01

    Full Text Available Benzodiazepines have a various behavioral effects in addition to their anxiolytic action. There is every reason to believe that the BZ/GABA receptor complex is involved in these effects, since GABAmimetic manipulations modify the effect of BZ in tests of convulsive activity, motor function, and appetitive behavior. 1,5-Benzodiazepines are biologically important molecules and are extensively used clinically as analgesic, hypnotic, sedative, and antidepressive agents. Hence, 1,5-Benzodiazepines were synthesized by condensation of o-phenylenediamine and ketones, for example, cyclohexanone and acetone in presence of sulfated zirconia (catalyst. Mannich bases were synthesized with acetophenone, p-nitroacetophenone, p-chloroacetophenone, and formaldehyde. Schiff bases were synthesized using Mannich base of 1,5-benzodiazepines with p-chloroaniline and p-chlorophenylsemicarbazide in the presence of glacial acetic acid. All the synthesized compounds were characterized by 1H NMR and IR spectral analyses. All the synthesized derivatives were evaluated at the dose of 30 mg/kg b.w for anticonvulsant activity by isoniazid induced convulsion model, and the compounds NBZD-3 and NBZD-8 were found to be the most active among all compounds. Among all the synthesized derivatives, compounds NBZD-13 and NBZD-17 were found to be the most active among all compounds using thiosemicarbazide induced model. Although NBZD-8, NBZD-10, and NBZD-18 are the compounds which had shown good anticonvulsant activity and have an advantage over that, they were not sedative.

  13. A new Mannich base and its transition metal (II) complexes - Synthesis, structural characterization and electrochemical study

    Indian Academy of Sciences (India)

    N Raman; S Esthar; C Thangaraja

    2004-06-01

    new Mannich base, N-(1-morpholinobenzyl) semicarbazide (MBS), formed by the condensation of morpholine, semicarbazide and benzaldehyde, and its Cu(II), Ni(II), Co(II) and Zn(II) complexes have been synthesized. Their structures have been elucidated on the basis of analytical, magnetic, electrical conductivity and spectral study as well as elemental analyses. The complexes exhibit square-planar geometry. The monomeric and non-electrolytic nature of the complexes is evidenced by their magnetic susceptibility and low conductance data. The electrochemical property of the ligand and its complexes in acetonitrile solution was studied by cyclic voltammetry. The X-band ESR spectra of the Cu(II) complex in DMSO at 300 and 77 K were recorded and their salient features are reported.

  14. Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole.

    Science.gov (United States)

    Parlak, A E; Celik, S; Karatepe, M; Turkoglu, S; Alayunt, N O; Dastan, S D; Ulas, M; Sandal, S; Tekin, S; Koparir, M

    2016-01-01

    In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies. PMID:27453272

  15. Inhibition of Mild Steel Corrosion in 1M H2SO4 Medium by Benzimidazole Mannich bases

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    P. M. Dasami

    2015-03-01

    Full Text Available The corrosion inhibition behaviour of two synthesized Mannich bases has been investigated for mild steel in 1M H2SO4 by weight loss and electrochemical techniques.The inhibition efficiency depends on concentration of the inhibitor and temperature. The inhibitors function by adsorption on mild steel surface and obey Langmuir isotherm indicating monolayer adsorption on the surface. Thermodynamic parameters show that the adsorption of the inhibitors occurs through electrostatic interaction. Polarization studies reveal that the inhibitors behave as mixed type in 1M H2SO4 affecting both anodic metal dissolution and cathodic hydrogen evolution. SEM studies show the formation of surface adsorptive film of the Mannich bases on the mild steel surface.

  16. SYNTHESIS OF BIS-PYRIMIDO IMIDAZOLE FUSED RING HETEROCYCLIC ADDUCT WITH UREAS OF MANNICH BASE FOR CNS DEPRESSION

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    AVANI H. SHETH*, PARIMAL M. PRAJAPATI, YATRI R. SHAH AND DHRUBO JYOTI SEN

    2009-12-01

    Full Text Available Mannich bases as well as urea derivatives have potent CNS depression activity. In our project work we have chosen aCNS drug which blocks the GABA receptor as well as chloride channel. Benzodiazepines have closed chain amidelinkage which acts on GABA (gamma amino butyric acid receptor and produces CNS depression with the blockageof chloride channel. This receptor has free amino and carboxylic acid functional group which produces amide linkagein-vivo.

  17. Identification of Mannich Base as a Novel Inhibitor of Mycobacterium Tuberculosis Isocitrate by High-Throughput Screening

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    Lei Ji, Quanxin Long, Dacheng Yang, Jianping Xie

    2011-01-01

    Full Text Available Mycobacterium tuberculosis (MTB remains one of the most significant human pathogens since its discovery in 1882. An estimated 1.5 million people died from tubercle bacillus (TB in 2006, and globally, there were an estimated 9.27 million incident cases of TB in 2007. Glyoxylate bypass pathway occurs in a wide range of pathogens and plays a key role in the pathogenesis of Mycobacterium tuberculosis. Isocitrate lyase (ICL can catalyses the first step of this pathway, and reversibly cleaves isocitrate into succinate and glyoxylate. So, ICL may represent a good drug target for the treatment of tuberculosis. ICL was cloned, expressed, and purified, and a high-throughput screen (HTS developed to screen active molecule from a mannich base compounds library for inhibition of ICL. This assay had signal to noise (S/N of 650.6990 and Z' factor of 0.8141, indicating that the assay was suitable for HTS. Screening of a collection of 124 mannich base compounds resulted in the identification of one mannich base compound, which has a significant inhibitory activity. So, a new family of compound was first reported to inhibit the activity of Mycobacterium tuberculosis ICL. This family of compound might offer new avenue to explore better anti-tuberculosis and fungi drugs.

  18. Synthesis and Biological Activity of 1,3,4-Oxadiazole Mannich Bases Containing Pyrimidine Rings%含嘧啶环的1,3,4-噁二唑 Mannich 碱的合成及生物活性

    Institute of Scientific and Technical Information of China (English)

    沈生强; 孙晓红; 刘源发; 陈邦; 靳如意; 马海霞

    2014-01-01

    1,3,4-Oxadiazole derivatives were reported to possess a broad spectrum of biological activities, such as antifungal, antibacterial, antiviral and antitubercular. Mannich bases had also been reported as poten-tial biological agents, they were applicated in the fields of synthetic study and medicinal chemistry. In recent years, Mannich bases containing 1,3,4-oxadiazole ring had attracted a lot of attention and many Mannich ba-ses of 1,3,4-oxadiazole bearing heterocycle scaffold were reported to have special bioactivity. Nevertheless, literature revealed that there were no reports of a molecular scaffold that Mannich base of 1,3,4-oxadiazole bearing pyrimidine. Prompted by these observations, a series of 1,3,4-oxadiazole derivatives containing py-rimidine( E1-E15) was synthesized from 5-aryl-1,3,4-oxadiazole-2-thione ( C1-C3), formaldehyde and substituted aminopyrimidine ( D1-D5) by Mannich reaction. 5-Aryl-1,3,4-oxadiazole-2-thione derivatives (C1-C3) were prepared from aromatic acids as the starting material via esterification, hydrazinolysis and cy-clization. The structures of all title compounds were confirmed by elemental analysis, IR, 1 H NMR tech-niques. Furthermore, their biological activities to four vegetable pathogens containing Gibberll nicotiancola, Gibberlla saubinetii, Fusarium oxysporium f. sp. niveum, Pythium solani had been tested. The preliminary re-sults indicated that most of the compounds exhibit relatively good fungicidal activities, especially compounds E3 and E8 showed better biological activity than triazolone.%以芳香酸为原料,通过酯化、肼解及环化反应制得中间体5-芳基取代-1,3,4-噁二唑-2-硫酮(C1~C3),然后中间体与甲醛和取代氨基嘧啶(D1~ D5)发生 Mannich 反应得到一系列新型含有嘧啶环的1,3,4-噁二唑类衍生物(E1~ E15)。所得目标化合物的结构经元素分析、 IR 及1 H NMR 确认。初步的生物活性测定结果表明,大部分目标化合物对植物病原菌有很好

  19. Design, synthesis, and antimicrobial screening of novel pyridyl-2-amidrazone incorporated isatin mannich bases.

    Science.gov (United States)

    Kumar, N Saravana; Pradeep, T; Jani, G; Silpa, Divya; Kumar, B Vijaya

    2012-01-01

    Isatin is an endogenous compound and reported to possess a wide range of biological activities. Numerous papers have shown that the pyridyl-2-amidrazone nucleus possesses a potent antimicrobial activity. Based on these prior observations, we postulated that a compound containing both isatin and pyridyl-2-amidrazone pharmacophores could be very effective for antimicrobial activity. Unfavorable adsorption, distribution, metabolism, and excretion (ADME) properties can in many cases lead to the clinical trials failure of potentially successful drug candidates. Their evaluation, therefore, at an earlier stage is desired. Here, we also present the predicted ADME properties of our ligands through computation. All the compounds (2a(1-5)) exhibited a better solubility, diffusion, Log P, molecular weight, etc., with no violations making the ligands pharmacodynamically active and better oral absorptive series. Based on the results of computational design, a series of novel pyridyl-2-amidrazone-incorporated isatin Mannich bases were synthesized and screened for their antimicrobial activities. IR, (1)H-NMR, and Mass Spectroscopy data were consistent with the assigned structures. The results exhibited that all of the lead compounds showed good antimicrobial activities; noticeably, the compound 2a(2) showed the best activity against Candida albicans (16 μg/ml) and compound 2a(3) was found to be the most active derivative against Staphylococcus aureus and Escherichia coli at minimal inhibitory concentration values of 4 and 32 μg/ml, respectively. PMID:22470895

  20. Synthesis and Biological Evaluation of Scutellaria Flavone Cyclaneaminol Mannich Base Derivatives as Novel CDK1 Inhibitors.

    Science.gov (United States)

    Ha, Lisha; Qian, Yuan; Zhang, Shixuan; Ju, Xiulan; Sun, Shiyou; Guo, Hongmin; Wang, Qianru; Li, Kangjian; Fan, Qingyu; Zheng, Yang; Li, Hailiang

    2016-01-01

    Cyclin-dependent kinase 1 (CDK1) is the only necessary CDK in the cell proliferation process and a new target in the research and development of anti-cancer drugs. Natural flavones are selective CDK1 inhibitors which can suppress the proliferation of cancer cells. However, their bioavailability is poor. To solve these problems, 6 Scutellaria flavones were isolated from hydrolyzed products of Scutellaria baicalensis and used as lead compounds, 18 Scutellaria flavones cyclane-aminol Mannich base derivatives were semi-synthesized and their biological activity as novel CDK1 inhibitors was evaluated. Results indicated that the biological activity of 8-Hydroxypiperidinemethyl-baicalein (BA-j) is the highest among these compounds. BA-j is a selective CDK1 inhibitor, and has broad-spectrum anti-proliferative activity in human cancer cells (IC50 12.3μM). BA-j can capture oxygen free radicals (.O2(-)) and selectively increase intracellular H2O2 level in cancer cells and activated lymphocytes, thus inducing their apoptosis rather than in normal cells. These findings suggest that BA-j selectively induces apoptosis in cancer and activated lymphocyte by controlling intracellular H2O2 level, and can be developed into a novel anti-proliferative agent for the treatment of cancer, AIDS, and some immune diseases. PMID:26411959

  1. Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-yl)phenylmethyl)urea) on Hepatocellular Carcinoma

    OpenAIRE

    Vadanasundari Vedarethinam; Karthik Dhanaraj; Soundharrajan Ilavenil; Mariadhas Valan Arasu; Ki Choon Choi; Naif Abdullah Al-Dhabi; Srigopalram Srisesharam; Kyung Dong Lee; Da Hye Kim; Tamilvenvendan Dhanapal; Ravikumar Sivanesan; Han Sung Choi; Young Ock Kim

    2016-01-01

    The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-yl)phenylmethyl)urea (1,3-BPMU) against HEP-G2 hepatoma cells and diethylnitrosamine (DEN)-induced hepatocarcinoma (HCC) in albino rats. In vitro analysis results revealed that 1,3-BPMU showed significant cytotoxicity and cell growth inhibition in HEP-G2 hepatoma cells in a concentration-dependent manner. Furthermore, flow cytometry results indicated that 1,3-BPMU enh...

  2. In Vitro Antioxidant Evaluation of Some Mannich Bases which Contain Bis-1,2,4 -Triazole Derivative

    International Nuclear Information System (INIS)

    This study aims to examine the antioxidant effects of some Mannich bases containing bis-1, 2, 4 triazole, which are synthesized afresh. The antioxidant activities of the derivatives were measured using different methods in this study, including reducing power capacity, metal chelating activity, superoxide anion radicals scavenging activity, H/sub 2/ O/sub 2/ scavenging activity and hydroxyl radical scavenging. As a result, derivatives had efficient antioxidant and free radical scavenging activity when compared to ascorbic acid, BHT and alpha-tocopherol as associated antioxidants. (author)

  3. Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities.

    Science.gov (United States)

    Tugrak, Mehtap; Yamali, Cem; Sakagami, Hiroshi; Gul, Halise Inci

    2016-10-01

    Chalcones and Mannich bases are a group of compounds known for their cytotoxicities. In this study restricted chalcone analogue, compound 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one MT1, was used as a starting compound to synthesize new mono Mannich bases since Mannich bases may induce more cytotoxicity than chalcone analogue that they are derived from by producing additional alkylating center for cellular thiols. In this study, cyclic and acyclic amines were used to synthesize Mannich bases. All compounds were tested against Ca9-22 (gingival carcinoma), HSC-2, HSC-3 and HSC-4 (oral squamous cell carcinoma) as tumour cell lines and HGF (gingival fibroblasts), HPC (pulp cells) and HPLF (periodontal ligament fibroblasts) human normal oral cells as non tumour cell lines. Cytotoxicity, selectivity index (SI) values and potency selectivity expression (PSE) values expressed as a percentage were determined for the compounds. According to data obtained, the compound MT8 with the highest PSE value bearing N-methylpiperazine moiety seems to be a good candidate to develop new cytotoxic compounds and is suited for further investigation. PMID:26247355

  4. Antimicrobial and hypoglycemic activities of novel N-Mannich bases derived from 5-(1-adamantyl)-4-substituted-1,2,4-triazoline-3-thiones.

    Science.gov (United States)

    Al-Abdullah, Ebtehal S; Al-Tuwaijri, Hanaa M; Hassan, Hanan M; Haiba, Mogedda E; Habib, Elsayed E; El-Emam, Ali A

    2014-01-01

    The reaction of 5-(1-adamantyl)-4-ethyl or allyl-1,2,4-triazoline-3-thione with formaldehyde solution and various 1-substituted piperazines yielded the corresponding N-Mannich bases. The newly synthesized N-Mannich bases were tested for in vitro inhibitory activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Six compounds showed potent antibacterial activity against one or more of the tested microorganisms, while two compounds exhibited moderate activity against the tested Gram-positive bacteria. None of the newly synthesized compounds were proved to possess marked activity against Candida albicans. The oral hypoglycemic activity of six compounds was determined in streptozotocin (STZ)-induced diabetic rats. Four compounds produced significant strong dose-dependent reduction of serum glucose levels, compared to gliclazide at 10 mg/kg dose level (potency ratio > 75%). PMID:25514407

  5. Antimicrobial and Hypoglycemic Activities of Novel N-Mannich Bases Derived from 5-(1-Adamantyl-4-substituted-1,2,4-triazoline-3-thiones

    Directory of Open Access Journals (Sweden)

    Ebtehal S. Al-Abdullah

    2014-12-01

    Full Text Available The reaction of 5-(1-adamantyl-4-ethyl or allyl-1,2,4-triazoline-3-thione with formaldehyde solution and various 1-substituted piperazines yielded the corresponding N-Mannich bases. The newly synthesized N-Mannich bases were tested for in vitro inhibitory activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Six compounds showed potent antibacterial activity against one or more of the tested microorganisms, while two compounds exhibited moderate activity against the tested Gram-positive bacteria. None of the newly synthesized compounds were proved to possess marked activity against Candida albicans. The oral hypoglycemic activity of six compounds was determined in streptozotocin (STZ-induced diabetic rats. Four compounds produced significant strong dose-dependent reduction of serum glucose levels, compared to gliclazide at 10 mg/kg dose level (potency ratio > 75%.

  6. Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones

    OpenAIRE

    Essam M. Hussein; Masaret, Ghada S; Khairou, Khalid S

    2015-01-01

    Background Thiazolidinone, has been employed in the preparation of different important drugs required for treatment of inflammations, bacterial infections, and hypertension. Mannich bases have been shown to exhibit diverse biological activities, such as antibacterial, and antifungal activities. Spiroheterocycles including thiazolidine moiety have antimicrobial activity. Results In this study, a novel, rapid, and efficient protocol is developed for the synthesis of various 2-arylidine-1-thia-4...

  7. Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones

    OpenAIRE

    Hakan Bektas; Olcay Bekircan

    2008-01-01

    Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with...

  8. Synthesis of Schiff and Mannich bases of isatin derivatives with 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones.

    Science.gov (United States)

    Bekircan, Olcay; Bektas, Hakan

    2008-01-01

    Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, (1)H- and (13)C-NMR data and by elemental analysis. PMID:18830145

  9. Synthesis and Antimicrobial Activity of Schiff’s and N-Mannich Bases of Isatin and Its Derivatives with 4-Amino-N-Carbamimidoyl Benzene Sulfonamide

    Directory of Open Access Journals (Sweden)

    U. K. Singh

    2010-04-01

    Full Text Available Isatin and substituted Isatin were reacted with 4-amino-N-carbamimidoyl benzene sulfonamide to form a series of Schiff’s bases. The Mannich bases of these compounds were synthesized by reacting them with formaldehyde and secondary amine (piperidine. All the compounds were characterized by means of their IR, 1H NMR spectroscopic data and elemental analysis. The antimicrobial activity of the synthesized compounds was evaluated by tube dilution method. The synthesized compounds showed better antibacterial activity than the reference drugs.

  10. Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-ylphenylmethylurea on Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Vadanasundari Vedarethinam

    2016-05-01

    Full Text Available The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-ylphenylmethylurea (1,3-BPMU against HEP-G2 hepatoma cells and diethylnitrosamine (DEN-induced hepatocarcinoma (HCC in albino rats. In vitro analysis results revealed that 1,3-BPMU showed significant cytotoxicity and cell growth inhibition in HEP-G2 hepatoma cells in a concentration-dependent manner. Furthermore, flow cytometry results indicated that 1,3-BPMU enhanced early and late apoptosis. The maximum apoptosis was exhibited at a concentration of 100 μg/mL of 1,3-BPMU. In in vivo analysis, DEN treatment increased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5’NT with decreased antioxidant activity as compared to control rats. However, 1,3-BPMU treatment to DEN-induced rats decreased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5’NT and increased the activities of SOD, CAT, GPx, GST and GR (p < 0.05. Furthermore, 1,3-BPMU enhanced the apoptosis via upregulation of caspase-3 and caspase-9 and the downregulation of Bcl-2 and Bcl-XL mRNA expression as compared to DEN-induced rats. Histological and ultrastructural investigation showed that 1,3-BPMU treatment renovated the internal architecture of the liver in DEN-induced rats. In this study, the molecular and pre-clinical results obtained by treatment of DEN-induced rats with 1,3-BPMU suggested that 1,3-BPMU might be considered as an antitumor compound in the future.

  11. Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-yl)phenylmethyl)urea) on Hepatocellular Carcinoma.

    Science.gov (United States)

    Vedarethinam, Vadanasundari; Dhanaraj, Karthik; Ilavenil, Soundharrajan; Arasu, Mariadhas Valan; Choi, Ki Choon; Al-Dhabi, Naif Abdullah; Srisesharam, Srigopalram; Lee, Kyung Dong; Kim, Da Hye; Dhanapal, Tamilvenvendan; Sivanesan, Ravikumar; Choi, Han Sung; Kim, Young Ock

    2016-01-01

    The present study was designed to evaluate the antitumor effects of the synthetic Mannich base 1,3-bis-((3-hydroxynaphthalen-2-yl)phenylmethyl)urea (1,3-BPMU) against HEP-G2 hepatoma cells and diethylnitrosamine (DEN)-induced hepatocarcinoma (HCC) in albino rats. In vitro analysis results revealed that 1,3-BPMU showed significant cytotoxicity and cell growth inhibition in HEP-G2 hepatoma cells in a concentration-dependent manner. Furthermore, flow cytometry results indicated that 1,3-BPMU enhanced early and late apoptosis. The maximum apoptosis was exhibited at a concentration of 100 μg/mL of 1,3-BPMU. In in vivo analysis, DEN treatment increased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5'NT with decreased antioxidant activity as compared to control rats. However, 1,3-BPMU treatment to DEN-induced rats decreased the content of nucleic acids, LPO and the activities of AST, ALT, ALP, LDH, γGT and 5'NT and increased the activities of SOD, CAT, GPx, GST and GR (p < 0.05). Furthermore, 1,3-BPMU enhanced the apoptosis via upregulation of caspase-3 and caspase-9 and the downregulation of Bcl-2 and Bcl-XL mRNA expression as compared to DEN-induced rats. Histological and ultrastructural investigation showed that 1,3-BPMU treatment renovated the internal architecture of the liver in DEN-induced rats. In this study, the molecular and pre-clinical results obtained by treatment of DEN-induced rats with 1,3-BPMU suggested that 1,3-BPMU might be considered as an antitumor compound in the future. PMID:27187346

  12. Synthesis and Cytotoxic Evaluation of a Series of 2-Amino-Naphthoquinones against Human Cancer Cells

    Directory of Open Access Journals (Sweden)

    Thiago A. P. de Moraes

    2014-08-01

    Full Text Available The cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoacids with 1,4-naphthoquinone was assayed against SF-295 (glioblastoma, MDAMB-435 (breast, HCT-8 (colon, HCT-116 (colon, HL-60 (leukemia, OVCAR-8 (ovarian, NCI-H358M (bronchoalveolar lung carcinoma and PC3-M (prostate cancer cells and also against PBMC (peripheral blood mononuclear cells. The results demonstrated that all the synthetic aminonaphthoquinones had relevant cytotoxic activity against all human cancer lines used in this experiment. Five of the compounds showed high cytotoxicity and selectivity against all cancer cell lines tested (IC50 = 0.49 to 3.89 µg·mL−1. The title compounds were less toxic to PBMC, since IC50 was 1.5 to eighteen times higher (IC50 = 5.51 to 17.61 µg·mL−1 than values shown by tumour cell lines. The mechanism of cell growth inhibition and structure–activity relationships remains as a target for future investigations.

  13. Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones

    Directory of Open Access Journals (Sweden)

    Hakan Bektas

    2008-09-01

    Full Text Available Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, 1H- and 13C-NMR data and by elemental analysis.

  14. Evaluation of net antioxidant activity of mono- and bis-Mannich base hydrochlorides and 3-keto-1,5-bisphosphonates from their ProAntidex parameter

    Science.gov (United States)

    Lahbib, Karima; Tarhouni, Mohamed; Touil, Soufiane

    2015-07-01

    A series of mono- and bis-Mannich base hydrochlorides and of 3-keto-1,5-bisphosphonates were prepared and characterized on the basis of their infrared (IR), 1H, 13C and 31P NMR spectral data. All the title compounds were tested for their in vitro antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), H2O2, hydroxyl radical and Ferric Reducing Power (FRP) methods. The antioxidant activity of these compounds was analyzed simultaneously with their pro-oxidant capacity. The ratio of pro-oxidant to the antioxidant activity (ProAntidex) represents a useful index of the net free radical scavenging potential of the synthesized compounds. Ferrous, calcium and magnesium ion chelating abilities were also evaluated. All the tested compounds showed significant antioxidant activity and high ProAntidex.

  15. Synthesis of formazans from Mannich base of 5-(4-chlorophenyl amino-2-mercapto-1,3,4-thiadiazole as antimicrobial agents

    Directory of Open Access Journals (Sweden)

    Pramilla Sah

    2014-04-01

    Full Text Available 5-(4-Chlorophenyl amino-2-mercapto-1,3,4-thiadiazole (I was refluxed with formaldehyde and ammonium chloride in ethanol yielding the Mannich base 5-(4-chloro phenyl amino-3-aminomethyl-2-mercapto-1,3,4-thiadiazole (II. Esterification with 4-chloro-(2,6-dinitro phenoxy-ethyl acetate (III under anhydrous conditions gave the intermediate (IV. Subsequent hydrazinolysis with hydrazine hydrate gave the corresponding hydrazide 3-amino methyl-5-(4-chloro phenyl amino-2-mercapto-4′-(2′,6′-dinitro phenoxy-acetyl hydrazide (V. The hydrazide was converted into the Schiff bases (VIa–b by reacting with 2-chlorobenzaldehyde and 3-methoxy-4-hydroxy benzaldehyde in presence of methanol containing 2–3 drops of acetic acid. Diazotisation with aromatic amines, sulphanilic acid and sulphur drugs gave the formazans (VIIa–g respectively. Chemical structures have been established by elemental analysis and the spectral techniques of FTIR, 1H NMR and mass. Antimicrobial activity (in vitro was evaluated against the two pathogenic bacterial strains. Escherichia coli and Salmonella typhi, three fungal strains Aspergillus niger, Penicillium species and Candida albicans. The compounds have shown moderate activity.

  16. Vibrational spectra and electronic structure of 3-((1H-pyrrol-1-yl) methyl) naphthalen-2-ol - A computational insight on antioxidant active Mannich base

    Science.gov (United States)

    Boobalan, Maria susai; Tamilvendan, D.; Amaladasan, M.; Ramalingam, S.; Venkatesa Prabhu, G.; Bououdina, M.

    2015-02-01

    The 3-((1H-pyrrol-1-yl) methyl) naphthalen-2-ol (IFTN) is a class of synthesized organic Mannich base compound having antioxidant property of biological importance. A meticulous normal mode vibrational analysis has been carried out by comparing and contrasting the experimentally recorded FT-IR and FT-Raman spectra with simulated spectra of IFTN. Similarly the calculated 1H and 13C NMR of IFTN were correlated with experimental findings to understand the shielding and deshielding nature hold in it. The following other electronic structure properties were calculated such as equilibrium geometrical parameters, natural bond orbital analysis (NBO), frontier molecular orbital (FMO) characterization, statistical thermochemical properties against a range of temperatures and molecular electrostatic potential (MEP) imprint was carried out along with various charges such as APT, ESP, Hirshfeld, natural and Mulliken. All these predicted properties unlock the nature of total behavior of IFTN in various dimensions. These could be Lewis, non-Lewis interaction along with their respective energies, contribution of fragmented moieties for various orders of HOMO and LUMO, temperature consequences on enthalpy, entropy, and heat capacity. In addition, the MEP leads to find electrophilic, nucleophilic reactive sites on IFTN molecular surface. The entire computational calculations has been made on HF/6-31+G/6-311++G(d,p) and B3LYP/6-31+G/6-311++G(d,p) model chemistries. A complete electronic structure observation has been achieved by this theoretical analysis.

  17. Reação de Mannich: Metodologia Clássica na Formação de Ligação Carbono-Carbono

    Directory of Open Access Journals (Sweden)

    João Francisco Allochio Filho

    2013-08-01

    Full Text Available The Mannich reaction is a classical method for the preparation of b-aminoketones and aldeydes (Mannich bases and, as such, is one the most important reaction in organic chemistry. The resulting Mannich bases are of particular interest due to their biological activity, use as synthetic building blocks, and precursors of valuable pharmaceuticals products. In this context, various elegant stereoselective α-aminoalkylations have been developed.

  18. 天然黄酮Mannich碱衍生物的合成及生物活性研究%Synthesis and Bioactivity of Natural Flavones Mannich Base Derivatives

    Institute of Scientific and Technical Information of China (English)

    刘重阳; 阮文山; 王盛淳; 汪秋安

    2016-01-01

    Two naturally occurring flavones,apigenin-5,4′-dimethy ether(1) and lutedin-5,3′,4′-trimethyl ether(2),were synthesized through I2/Py dehydrogenation,O-methylation and glycoside hydrolysis reaction,using naringin and hesperidin as raw materials. Based on Mannich reaction of flavones 1 or 2 with various secondary amines and formaldehyde in acidic alcohol solvent with microwave assisted,fifteen novel flavones Mannich base derivatives 1-17 were synthesized. The structures of all synthesized compounds were confirmed by 1H NMR,13C NMR and MS techniques. Furthermore,all compounds were tested for anti-proliferative activities on human cervical carcinoma Hela cells using cell counting Kit-8(CCK-8). The results showed that compounds 1,2,7, 9,10,12 and 17 exhibited distinct anti-proliferative activities against Hela cells. Among them,compounds 10,12 and 17 displayed higher activities with inhibitory concentration 50%(IC50) of 16.13, 29.04 and 9.14 μmol/L than the positive control cis-platin (IC50 =41. 25 μmol/L).%以柚皮苷和橙皮苷为原料,经碘/吡啶脱氢,O-甲基化和糖苷水解等反应,分别合成了2种天然黄酮芹菜素-5,4′-二甲醚(1)和木犀草素-5,3′,4′-三甲醚(2)。然后以1和2为底物,分别与甲醛、二级胺在酸性醇溶剂中发生微波协助的Mannich反应,对黄酮8-位进行胺甲基化修饰,合成了15个新型黄酮Mannich碱衍生物3~17。所合成的化合物经1H NMR、13C NMR和MS等进行了结构确证,并采用细胞计数Kit-8(CCK-8)法测试了化合物1~17对子宫颈癌Hela细胞的体外抑制活性。结果表明,化合物1、2、7、9、10、12和17对Hela细胞增殖具有明显的抑制活性,其中化合物10、12和17的半数抑制浓度( IC50)分别为16.13、29.04和9.14μmol/L,活性高于阳性对照药物顺铂(IC50为41.25μmol/L)。

  19. 基于乙酸为溶剂和催化剂的芳乙酮Mannich反应%Mannich Reaction of Aromatic Ketones Based on Acetic Acid as Solvent and Catalyst

    Institute of Scientific and Technical Information of China (English)

    卜辉娟; 张静; 穆博帅; 李媛

    2014-01-01

    Mannich reaction is one of the most important methods for preparation ofβ-amino ketones and alde-hydes and α,β-unsaturated carbonyl compounds, as well as one of the most important basic reaction types in organic chemistry and it is widely applied as a key step in the synthesis of numerous pharmaceuticals and natu-ral products. However, during the synthesis of 1-aryl acrylic ketone 2 by the Mannich reaction of aromatic ke-tones, formaldehyde and secondary amine using acetic acid as solvent and catalyst, the Mannich base and ex-pectedα,β-unsaturated ketones 2 were not obtained and another kind of compounds 3 , 2-aryl formyl allyl ace-tate were obtained in moderate to good yields(65%-73%) . The structure of compounds 3 was confirmed by 1 H NMR, 13 C NMR, HRMS and IR spectra. The reasons of producing compounds 3 were studied and the re-sults suggested that the special structure of aromatic ketones and excess acetic acid in reaction are responsible for the exceptional Mannich reaction. In addition, the reaction mechanism was postulated.%采用乙酸作溶剂和催化剂,将芳乙酮与甲醛和二级胺进行Mannich反应及热解反应,并未得到预期的Mannich碱或α,β-不饱和酮(2),而是以较高产率(65%~73%)生成了乙酸(2-芳甲酰基)烯丙酯(3a~3o)。通过核磁共振波谱、高分辨质谱和红外光谱表征了化合物3a~3o的结构,研究了此“异常”反应的发生条件,并提出了可能的反应机理。结果表明,芳乙酮的特殊结构及反应中过量的乙酸是产生化合物3a~3o的决定因素。

  20. Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives.

    Science.gov (United States)

    Liu, Haoran; Fan, Haoqun; Gao, Xiaohui; Huang, Xueqing; Liu, Xianjun; Liu, Linbo; Zhou, Chao; Tang, Jingjing; Wang, Qiuan; Liu, Wukun

    2016-08-01

    In order to study the structure-activity relationship of Flavokawain B Mannich-based derivatives as acetylcholinesterase (AChE) inhibitors in our recent investigation, 20 new nitrogen-containing chalcone derivatives (4 a-8d) were designed, synthesized, and evaluated for AChE inhibitory activity in vitro. The results suggested that amino alkyl side chain of chalcone dramatically influenced the inhibitory activity against AChE. Among them, compound 6c revealed the strongest AChE inhibitory activity (IC50 value: 0.85 μmol/L) and the highest selectivity against AChE over BuChE (ratio: 35.79). Enzyme kinetic study showed that the inhibition mechanism of compound 6c against AChE was a mixed-type inhibition. The molecular docking assay showed that this compound can both bind with the catalytic site and the peripheral site of AChE. PMID:26186269

  1. Mannich reaction: A versatile and convenient approach to bioactive skeletons

    Indian Academy of Sciences (India)

    Selva Ganesan Subramaniapillai

    2013-05-01

    This review gives an insight into the recent applications of Mannich reaction and its variants in the construction of bioactive molecules. Emphasis is given to the Mannich reaction that provides bioactive molecules and/or modifies the property of an existing bioactive molecule. The role of Mannich reaction in the construction of antimalarial, antitumour, antimicrobial, antitubercular, antiinflammatory and anticonvulsant molecules and also the significance of aminoalkyl Mannich side chain on the biological property of molecules is discussed here.

  2. Novel Synthesis and Anti-Microbial Activity Study of Innovative Mannich Bases Containing 2- Phenoxy-1, 3, 2-Dioxa Phospholanes And Indole Systems

    Directory of Open Access Journals (Sweden)

    Subba Narayana Kanchana

    2014-09-01

    Full Text Available In the present study, synthesis, characterization, antimicrobial activity on some novel pyrazolone derivatives has been taken up. The primary amines were diazotized with sodium nitrite and HCl mixture at 0-5 0C which were further coupled with ethyl acetoacetic ester to afford phenyl diazonium acetoacetic esters (II. Condensation of 4-substituted aryl hydrazono acetoacetic ester, 4-hydrazinylbenzenamine in the presence of catalytic amount of DMF under microwave irradiation afforded (4Z-4-(2-substituted aryl hydrazono-1-(4-aminophenyl-3-methyl-1H-pyrazol-5(4H-one (III. Subjecting (III to anhydrous K2CO3 in DMF for 8 hours afforded 2-{4-[(4Z-4-(2-substituted aryl hydrazono-4, 5-dihydro-3-methyl-5-oxopyrazol-1-yl] phenyl amino} acetate( IV which was further reacted with hydrazine hydrate to afford 2-{4-[(4Z-4-(2-substituted aryl hydrazono-4, 5-dihydro-3-methyl-5-oxopyrazol-1-yl] phenylamino} acetohydrazide (V. Reaction of (V and Isatin (VI b in DMF afforded (4Z-2-(4-((15Z-4-(2-phenylhydrazono-4,5-dihydro-3-methyl-5 oxopyrazol-1-ylphenylamino-N'-(2-oxoindolin-3-ylideneacetohydrazide (VII. Compound (VII was subsequently subjected to Mannich reaction with cyclic secondary amines (piperidine/morpholine/N-methyl piperidine in the presence of formaldehyde in DMF to afford (4Z-2-(4-((15Z-4-(2-substituted aryl hydrazono-4,5-dihydro-3-methyl-5-oxopyrazol-1-ylphenylamino-N'-(2-oxo-1-((piperidin-1-ylmethylindolin-3-ylideneacetohydrazide (VIII which was characterized by I.R, 1HNMR and Mass data. The anti-bacterial activity of synthesized compounds was studied by the disc diffusion method against pathogenic bacteria and fungi.

  3. 芳香酮曼尼希碱酸化缓蚀剂的合成及复配研究%Synthesis and complex of the corrosion inhibitor of mannich bases of aromatic ketones

    Institute of Scientific and Technical Information of China (English)

    王霞; 白媛丽; 罗全民; 刘志辉

    2012-01-01

    37% Formaldehyde solution,acetophenone and diethylamine were chosed ultimately and these materials compounded a new type of mannich base hydrochloride acid inhibitor, and its complex research. The results showed that the best synthetic process conditions is diethylamine, formaldehyde, acetophenone molar ratio is:2:2:1 .reaction time is 8 h,reaction temperature is 80℃,,reaction system pH value is 4. Sodi-um tungstate and corrosion inhibitor have a positive synergies, potassium iodide negative synergistic effect.%以37%的甲醛溶液、苯乙酮和二乙胺为原料,合成一种新型曼尼希碱盐酸酸化缓蚀剂,并对其进行复配研究.结果表明,最佳合成条件为:二乙胺、37%甲醛溶液和苯乙酮的摩尔比为2:2:1,反应时间8h,反应温度80 ℃,pH值为4;钨酸钠和缓蚀剂有着很好的正协同效应,碘化钾与其有负协同效应.

  4. Synthesis of Mannich Base by One-pot Method with Aromatic Aldehyde, Acetophenone and p-Nitroaniline%芳香醛、苯乙酮和对硝基苯胺一锅法合成Mannich碱

    Institute of Scientific and Technical Information of China (English)

    温俏; 李小花; 林春秀; 徐达; 刘春玲

    2015-01-01

    在浓盐酸做催化剂的条件下,芳香醛、苯乙酮和对硝基苯胺能够发生Mannich反应,经过提纯得到相应的Mannich碱。用红外光谱对产物的结构进行表征,并研究浓盐酸的使用量、反应温度、反应时间等条件对产率的影响。实验发现在3滴浓盐酸催化下,控温在15~20℃,反应20 h,产率可达60%左右。%The Mannich base were synthesized by one-pot method with aromatic aldehyde, acetophenone and p-nitroaniline in concentrated hydrochloric acid. The structural properties of the products were characterized by IR spectrum. The influence of the factors of the quantity of catalyst, the reaction time and temperature on the product yield was systematically studied. It was found that under the conditions of 3 drops of concentrated hydrochloric acid as catalysis, in 15~20 ℃ and for 20 h, the production rate can reach 60%.

  5. 多曼尼希碱型酸化缓蚀剂的研制及性能评价%Synthesis of a multi-Mannich base corrosion inhibitor and its performance under acidification

    Institute of Scientific and Technical Information of China (English)

    全红平; 鲁雪梅; 鲜菊

    2016-01-01

    以肉桂醛、苯乙酮、多胺和甲醛为原料,通过曼尼希反应合成多曼尼希碱型酸化缓蚀剂M-4A,通过单因素法对合成条件进行优选的结果:温度70~80℃,时间6~7 h,n(肉桂醛)∶n(二乙烯三胺)∶n(苯乙酮)∶n(甲醛)=(1.1~1.2)∶1.0∶(2.1~2.3)∶(1.1~1.2)。采用FTIR和SEM等方法对最优产物结构进行表征,分析M-4A在酸液介质中的缓蚀性能及与KI和CuBr复配后的缓蚀性能。实验结果表明,在90℃下的20%(w)HCl和土酸(HF 3%(w)+ HCl 12%(w))中,M-4A最佳加入量(w)分别为0.5%和0.7%,A3钢的腐蚀速率为3.95 g/(m2·h)和3.05 g/(m2·h),缓蚀率高达99.92%和99.90%。M-4A分别与KI和CuBr 增效剂复配后缓蚀性能提高,在20%(w)的HCl中,当KI和CuBr与M-4A的质量比为1∶3复配后,A3钢的腐蚀速率最小为0.96 g/(m2·h)和2.67 g/(m2·h)。%In order to inhibit the corrosion of acid solutions to metal equipments used in oilfield acidification,a multi-Mannich base corrosion inhibitor,M-4A,was synthesized through the Mannich reaction from cinnamic aldehyde,acetophenone,diethylenetriamine and formaldehyde. The synthesis conditions were optimized by single factor method,and the optimal product was characterized by means of FTIR and SEM. The corrosion inhibition efficiency of M-4A in acid solution was evaluated by means of TG and SEM. The results showed that,The optimal conditions for the synthesis were temperature of 70-80℃,reaction time of 6-7 h andn(cinnamic aldehyde)∶n(diethylenetriamine)∶n(acetophenone)∶n(formaldehyde) of (1.1-1.2)∶1.0∶(2.1-2.3)∶(1.1-1.2). At 90℃ in 20%(w) hydrochloric acid solution and mud acid (3%(w) HF + 12%(w) HCl) solution,the optimal M-4A dosages were 0.5%(w) and 0.7%(w),the corrosion rates of A3 steel sheet were 3.95 g/(m2·h) and 3.05 g/(m2·h),and the inhibition efficiency achieved 99.92% and 99.90%,respectively. When M-4A was

  6. Study on the Synthesis and Performance of a Mannich Based Acidification Corrosion Inhibitor%曼尼希酸化缓蚀剂H-402的合成及其缓蚀性能研究

    Institute of Scientific and Technical Information of China (English)

    张勇; 陆原; 张颖; 胡廷; 赵璐

    2013-01-01

    A oilfield acidification corrosion inhibitor was synthesized by Mannich reaction of secondary amine, acetophenone and formaldehyde. The effect of the synthetic technology, including molar ratio of reactant, reaction temperature and reaction time, on the inhibition performance of the inhibitor was evaluated by coupon corrosion tests. In addition, the inhibition mechanism of the inhibitor was investigated by electrochemical test and scanning electronic microscope observation. The results showed that the inhibitor exhibited the best inhibition efficiency when the molar ratio of primary amine, acetophenone and formaldehyde was 1:2:5 and the reaction were maintained at 80℃ for 10 h. After compounded with polyether and propargyl alcohol, the inhibitor could reach the first-class level at the dosage of 0.5%. The corrosion inhibitor was assigned as a mixed inhibitor mainly which inhibited the anode process through electrochemistry method. The scanning electronic microscope observation indicated that the corrosion forms of steels were improved significantly after adding 0.5% corrosion inhibitor.%本文采用仲胺、苯乙酮、甲醛为原料,通过曼尼希缩合反应,合成了一种油田酸化缓蚀剂H-402,研究了合成工艺对产物性能的影响及缓蚀机理.结果表明:在仲胺/苯乙酮/甲醛摩尔比1∶2∶5、反应温度80℃、反应时间10h条件下,所合成的H-402的缓蚀效果最佳.该缓蚀剂与聚醚、丙炔醇等具有增效作用,加剂量为0.5%时达到缓蚀剂一级水平.该缓蚀剂为抑制阳极过程为主的混合型缓蚀剂.扫描电镜显示,加入0.5%H-402后,Q235挂片表面的腐蚀形态得到极大的改善.

  7. Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.

    Science.gov (United States)

    Limanto, John; Yoshikawa, Naoki; Reamer, Robert A; Tan, Lushi; Brunskill, Andrew; Reibarkh, Mikhail

    2016-01-15

    Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxazolidone-derived titanium enolate and an aromatic aldimine was found to occur only after introduction of a proton source. While various protic additives could be used to promote the transformation, the best results were obtained using AcOH to afford the corresponding Mannich products in high diastereoselectivities and yields. PMID:26656787

  8. Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides.

    Science.gov (United States)

    Brewitz, Lennart; Arteaga, Fernando Arteaga; Yin, Liang; Alagiri, Kaliyamoorthy; Kumagai, Naoya; Shibasaki, Masakatsu

    2015-12-23

    The last two decades have witnessed the emergence of direct enolization protocols providing atom-economical and operationally simple methods to use enolates for stereoselective C-C bond-forming reactions, eliminating the inherent drawback of the preformation of enolates using stoichiometric amounts of reagents. In its infancy, direct enolization relied heavily on the intrinsic acidity of the latent enolates, and the reaction scope was limited to readily enolizable ketones and aldehydes. Recent advances in this field enabled the exploitation of carboxylic acid derivatives for direct enolization, offering expeditious access to synthetically versatile chiral building blocks. Despite the growing demand for enantioenriched fluorine-containing small molecules, α- and β-fluorinated carbonyl compounds have been neglected in direct enolization chemistry because of the competing and dominating defluorination pathway. Herein we present a comprehensive study on direct and highly stereoselective Mannich-type reactions of α- and β-fluorine-functionalized 7-azaindoline amides that rely on a soft Lewis acid/hard Brønsted base cooperative catalytic system to guarantee an efficient enolization while suppressing undesired defluorination. This protocol contributes to provide a series of fluorinated analogs of enantioenriched β-amino acids for medicinal chemistry. PMID:26652911

  9. RUTHENIUM-CATALYZED TANDEM OLEFIN MIGRATION-ALDOL AND MANNICH-TYPE REACTIONS IN IONIC LIQUID.

    Science.gov (United States)

    In the presence of a catalytic amount of RuCl2(PPh3)3, a cross-coupling of 3-buten-2-ol with aldehydes and imines was developed via a tandem olefin migration--aldol--Mannich reaction in bmim[PF6]. With In(OAc)3 as a co-catalyst, a-vinylbenzyl alcohol and aldehydes underwent sim...

  10. ALDOL- AND MANNICH-TYPE REACTIONS VIA IN SITU OLEFIN MIGRATION IN IONIC LIQUID

    Science.gov (United States)

    An aldol-type and a Mannich-type reaction via the cross-coupling of aldehydes and imines with allylic alcohols catalyzed by RuCl2(PPh3)3 was developed with ionic liquid as the solvent. The solvent/catalyst system could be reused for at least five times with no loss of reactiv...

  11. Stereoselective access to heteroarylmethylene-substituted pyrrolidines: fully organocatalytic Mannich-hydroamination reactions.

    Science.gov (United States)

    Jean, Alexandre; Blanchet, Jérôme; Rouden, Jacques; Maddaluno, Jacques; De Paolis, Michaël

    2013-02-25

    A one-pot sequence of organocatalytic transformations delivers heteroarylmethylene-substituted pyrrolidines with high stereo- and enantioselectivity. A Mannich coupling of N-heteroarylalkyne aldehydes with aldimine and an original metal-free hydroamination of the resulting adducts are the key transformations of the process delivering highly functionalized molecules with high potential for synthetic applications. PMID:23340658

  12. Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction

    Science.gov (United States)

    Caputo, Samantha; Basso, Andrea; Moni, Lisa; Riva, Renata; Rocca, Valeria

    2016-01-01

    Summary Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good. This approach represents a step-economical path to enantiomerically pure, polyfunctionalized peptidomimetics endowed with three stereogenic centers, allowing the introduction of five diversity inputs. PMID:26877816

  13. Study on the Synthesis and Corrosion Inhibition Performance of Mannich-Modified Imidazoline

    Directory of Open Access Journals (Sweden)

    Xiangjun Kong

    2016-07-01

    Full Text Available A novel Mannich-modified imidazoline (MMI as cationic emulsifier was synthesised for corrosion harm reduction, through three steps — acylation, cyclization, and Mannich reaction. The surface activity was characterized by determination of surface tensions and critical micelle concentration (CMC. The corrosion inhibition performance of five types of steels in the simulated corrosion solution in the presence of the MMI was investigated by static weight loss tests. The results showed that the MMI had good surface activities, with CMC of 19.8 μg g−1 and surface tension of 36.4 mN m−1. The corrosion test results indicated that the corrosion rates of different materials were decreased significantly, and degrees of corrosion inhibition were always higher than 80.0 %. The main inhibition mechanism was most likely due to the adsorption of the corrosion inhibitor on the steel surface, leading to the prevention of corrosion medium from the metal surface.

  14. Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step

    Directory of Open Access Journals (Sweden)

    James C. Anderson

    2013-08-01

    Full Text Available Piperazirum, isolated from Arum palaestinum Boiss, was originally assigned as r-3,c-5-diisobutyl-c-6-isopropylpiperazin-2-one. The reported structure was synthesised diastereoselectively using a key nitro-Mannich reaction to set up the C5/C6 relative stereochemistry. The structure was unambiguously assigned by single crystal X-ray diffraction but the spectroscopic data did not match those reported for the natural product. The structure of the natural product must therefore be revised.

  15. Accurate Reaction Enthalpies and Sources of Error in DFT Thermochemistry for Aldol, Mannich, and α-Aminoxylation Reactions

    OpenAIRE

    Wheeler, Steven E.; Moran, Antonio; Pieniazek, Susan N.; Houk, K. N.

    2009-01-01

    Enthalpies for bond-forming reactions that are subject to organocatalysis have been predicted using the high-accuracy CBS-QB3 model chemistry and six DFT functionals. Reaction enthalpies were decomposed into contributions from changes in bonding and other intramolecular effects via the hierarchy of homodesmotic reactions. The order of the reaction exothermicities (aldol < Mannich ≈ α-aminoxylation) arises primarily from changes in formal bond types mediated by contributions from secondary int...

  16. Synthesis of Arctigenin Mannich Derivative%牛蒡苷元曼尼希反应产物的合成

    Institute of Scientific and Technical Information of China (English)

    徐煜彬; 窦德强

    2013-01-01

    目的:合成牛蒡苷元曼尼希反应产物4-(3″,4″-二甲氧苄基)-3-(4′-羟基-3'-甲氧基-5′-(哌啶-1-基甲基)苯甲基)二氢呋喃-2 (3H)-酮.方法:本实验采用曼尼希的方法对牛蒡苷元酚羟基邻位进行结构修饰,牛蒡苷元与哌啶溶液反应合成曼尼希反应产物.结论:通过对合成工艺条件进行较为详细的考察,确定最佳工艺条件.%Objective:4-(3",4"-dimethoxybenzyl)-3-(4'-hydroxy-3'-methoxy-5'-(piperidin-1-ylmethyl) benzyl) dihydrofuran-2 (3H)-one,Mannich derivative of arctigenin was yielded.Method:Structure modification in phenolic hydroxyl group Ortho of arctigenin with Mannich method was carried out.The Mannich derivative was synthesized by treating arctigenin and piperidine solution.Conclusion:The art of the synthesis process was investigated in detail to determine the optimal process conditions.

  17. Synthesis of New Salen Ligands by Mannich Reaction%由Mannich反应合成新型Salen配体

    Institute of Scientific and Technical Information of China (English)

    王暖升; 李俊英; 李天铎

    2012-01-01

    以乙二胺或乙二胺衍生物为碱,与甲醛、对甲酚通过Mannich反应生成了四种N,N′-双(水杨醛)乙二胺(salen)配体,其中3个为新化合物.其结构经1H NMR,IR,MS和元素分析表征.%Four Salen ligangds(three of them are novel) were synthesized by Mannich condensation of ethanediamine or ethylenediamine derivatives with formaldehyde and p-cresol. The structures were characterized by 'H NMR, IR, MS and elemental analysis.

  18. A tandem Mannich addition–palladium catalyzed ring-closing route toward 4-substituted-3(2H-furanones

    Directory of Open Access Journals (Sweden)

    Jubi John

    2014-06-01

    Full Text Available A facile route towards highly functionalized 3(2H-furanones via a sequential Mannich addition–palladium catalyzed ring closing has been elaborated. The reaction of 4-chloroacetoacetate esters with imines derived from aliphatic and aromatic aldehydes under palladium catalysis afforded 4-substituted furanones in good to excellent yields. 4-Hydrazino-3(2H-furanones could also be synthesized from diazo esters in excellent yields by utilising the developed strategy. We could also efficiently transform the substituted furanones to aza-prostaglandin analogues.

  19. 2-methyl-3-butyn-2-ol as an acetylene precursor in the Mannich reaction. A new synthesis of suicide inactivators of monoamine oxidase

    International Nuclear Information System (INIS)

    A two-step reaction process is reported for the synthesis of 11C, 13C, or 14C-labelled propargylamines in moderate yields. The propargylamines were prepared by a modified Mannich scheme without the use of acetylene. The reaction scheme involved the use of 2-methyl-3-butyn-2-ol followed by KOH-catalyzed elimination of acetone from the acetylenic carbinols

  20. Direct carbon-carbon bond formation via reductive soft enolization: a syn-selective Mannich addition of α-iodo thioesters.

    Science.gov (United States)

    Truong, Ngoc; Sauer, Scott J; Seraphin-Hatcher, Cyndie; Coltart, Don M

    2016-08-16

    The β-amino carboxylic acid moiety is a key feature of numerous important biologically active compounds. We describe a syn-selective direct Mannich addition reaction that uses α-iodo thioesters and sulfonyl imines and produces β-amino thioesters. Enolate formation is achieved by reductive soft enolization. The products of the reaction provide straightforward access to biologically important β-lactams through a variety of known reactions. PMID:27492274

  1. An efficient synthesis of β-amino ketone compounds through one-pot three-component Mannich-type reactions using bismuth nitrate as catalyst

    Directory of Open Access Journals (Sweden)

    S. Sheik Mansoor

    2015-07-01

    Full Text Available Three components one-pot Mannich reaction of aromatic ketone, aromatic aldehyde and aromatic amines has been efficiently catalyzed by recyclable bismuth nitrate (Bi(NO33, BN at ambient temperature to give various β-amino carbonyl compounds in high yields. This method has advantages of mild condition, no environmental pollution, and simple work-up procedures. Most importantly, β-amino carbonyl compounds with ortho-substituted aromatic amines are obtained in acceptable to moderate yields by this methodology.

  2. A Chiron-based Approach for the Synthesis of Tricyclic Tyrosine Analogue

    Institute of Scientific and Technical Information of China (English)

    LIU Fa刘发; JIAO Jiao焦姣; ZHA Hui-Yan查慧艳; YAO Zhu-Jun姚祝军

    2004-01-01

    A chiron approach-based enantioselective synthesis of designed tricyclic tyrosine analogue D-2 was developed.A SmI2-mediated free radical cyclization, an intramolecular Friedel-Crafts reaction and an intramolecular Mannich reaction served as key steps. These key steps were optimized and repeated in good yields. All the stereochemistries in the synthesis were established and confirmed.

  3. 曼尼希反应在木质素的改性中的应用%Application of Mannich Reaction in Modification of Lignin

    Institute of Scientific and Technical Information of China (English)

    岳萱; 乔卫红; 申凯华; 李宗石

    2001-01-01

      本文综述了木质素与脂肪胺的曼尼希反应的机理,反应物的种类和反应条件,并且详细介绍了反应产物木素胺及其衍生物在石油开采、沥青乳化、污水处理、染料分散等方面的应用进展。%  This paper reviews the mechanism, reactants and conditions of the Mannich Reaction which has been used extensively in the modification of lignin with amines. The developments of the applications of lignin amines and derivatives in oil recovery, asphalt emulsion, sewage treatment and dye dispersion have been discussed in detail.

  4. Synthesis of Mannich Bases of Some 2,5-Disubstituted 4-Thiazolidinones and Evaluation of Their Antimicrobial Activities

    OpenAIRE

    ALTINTAŞ, Handan; ATEŞ, Öznur; BİRTEKSÖZ, Seher; Ötük, Gülten

    2005-01-01

    4-Carbethoxymethyl-2-[(a -chloropropionyl/a -bromobutyryl/a-chloro-(a-phenyl)acetyl)amino]thiazoles (2a-c) were synthesized by the reaction of 4-carbethoxymethyl-2-aminothiazole (1) with a-chloropropionyl chloride, a-bromobutyryl bromide and a-chloro-a -phenylacetyl chloride, respectively, which were then refluxed with ammonium thiocyanate to obtain 5-substituted 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones (3a-c). 3a-c were stirred with formaldehyde and various second...

  5. Exogenous bridging and nonbridging in Cu(II) complexes of Mannich base ligands: Synthesis and physical properties

    Indian Academy of Sciences (India)

    S Sujatha; T M Rajendiran; R Kannappan; R Venkatesan; P Sambasiva Rao

    2000-12-01

    Preparation of pentadentate ligands L1, L2, L3 and L4, where L1=4-chloro-3-methyl-2[(prolin-1-yl)methyl]-6-[N-phenyl piperazin-1-yl)methyl]phenol, L2= 4-ethyl-2-[(prolin-1-yl)methyl]-6-[(N-phenyl piperazin-1-yl)methyl]phenol, L3 =4-chloro-3-methyl-2-[(prolin-1-yl)methyl]-6-[N-methyl piperazin-1-yl]methyl phenol, L4 = 4-methoxy-2-[(prolin-1-yl)methyl]-6-[(N-phenyl piperazin-1-yl)methyl]phenol is described together with that of the corresponding Cu(II) complexes with various bridging motifs like OH, OAc and NO2. The complexes are characterized by elemental analysis, electrochemical and electron paramagnetic spectral studies. Redox properties of the complexes in acetonitrile are highly quasireversible due to the chemical or/and stereochemical changes subsequent to electron transfer. The complexes show resolved copper hyperfine EPR at room temperature, indicating the presence of weak antiferromagnetic coupling between the copper atoms. Strengths of the antiferromagnetic interactions are in the order NO2 > OAc > OH.

  6. Novel 3-(aminomethyl)naphthoquinone mannich base-platinum(IV) complexes: synthesis, characterization, electrochemical and cytotoxic studies

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Gustavo B. da; Neves, Amanda P.; Vargas, Maria D., E-mail: mdvargas@vm.uff.br [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Instituto de Quimica; Alves, Wagner A. [Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropedica, RJ (Brazil). Departamento de Quimica; Marinho-Filho, Jose D.B.; Pessoa, Claudia; Moraes, Manoel O.; Costa-Lotufo, Leticia V. [Universidade Federal do Ceara (UFCE), Fortaleza, CE (Brazil). Centro de Ciencias da Saude. Departamento de Fisiologia e Farmacologia

    2013-04-15

    Three novel platinum(IV) complexes cis,cis,trans-[Pt(HL1-3)Cl{sub 2}(OH){sub 2}] 1b-3b(HL = 2-hydroxy-3-[(R{sup 1} -amino)(pyridin-2-yl)methyl]-1,4-naphthoquinone, R{sup 1} = n-butyl, HL1; n-heptyl, HL2 and n-decyl, HL3) have been obtained from the oxidation of the respective precursors cis-[Pt(HL1-3)Cl{sub 2}] 1a-3a. Cyclic voltammetry studies of 1b-3b in MeCN showed the quasi reversible naphthoquinonate (NQO{sup -}, i.e., L{sup -}) redox process and irreversible process attributed to the reduction of the Pt{sup 4+}/Pt{sup 2+} pair, at potentials about 400 mV less negative than for the cisplatin precursor cis,cis,trans-[Pt(NH{sub 3}){sub 2}Cl{sub 2}(OH){sub 2}]. Hydrogen bond interaction between the naphthoquinone 2-hydroxyl group and an axially coordinated hydroxide ligand in 1b-3b has been proposed to favor the Pt{sup 4+}/Pt{sup 2+} reduction. The cytotoxicity studies against four human cancer cell lines have shown that in general the platinum(IV) and platinum(II)derivatives exhibit the same cytotoxic profile and are all more active than cisplatin. The lowest in vitro IC{sub 50} values have been observed for 2b-3b, which bear ligands with the largest R{sup 1} groups (HL2-HL3) being the most lipophilic. Furthermore similar IC{sub 50} values for platinum(II) and platinum(IV) complexes of the same ligands have been associated with rapid in vitro reduction of the latter complexes to afford 1a-3a. (author)

  7. STUDY ON THE MANNICH REACTION OF PAM INVERSE MICROLATICES%丙烯酰胺反相微胶乳的Mannich反应研究

    Institute of Scientific and Technical Information of China (English)

    赵勇; 何炳林

    2001-01-01

    The Mannich reaction of PAM inverse microl atices were carried out in the way of microreactor for the first time, which gua ranted the balance and steadiness of reaction because of avoiding the coacervati on of microlatex particles. The experiment shows that temperature and pH value are the important influencing factors on product properties. In the experimental condition of temperature at 50 ℃ and pH at 2, aminated PAM inverse microlatices were prepared, of which amination degree was 58% and storage stability was one year.%首次选用微乳液反应器形式进行了PAM反相微胶乳的Mannich反应,由于避免了因胶乳粒子凝聚而出现的破乳现象,使得反应均衡和平稳。研究发现,温度和pH是影响产物性能的重要因素 。在T=50 ℃,pH=2的条件下,制得了胺化度为58%,稳定性长达1 a的胶乳产品。

  8. Detergent-dispersant additives based on high-molecular-weight alkylphenols

    Energy Technology Data Exchange (ETDEWEB)

    Kulieva, K.N.; Namazova, I.I.; Ismailova, N.D.; Dorokhina, I.V.

    1988-09-01

    This article describes the synthesis and investigation of Mannich bases produced for alkylphenols, obtained in turn from ethylene oligomers. These oligomers are the still bottoms from distillation products of high-temperature oligomerization of ethylene in the presence of triethylaluminum. Two narrow cuts obtained from the distillation of oligomer fraction were used to study the influence of ethylene oligomer molecular weight on the properties of the additives. The additives were blended in DS-11 oil to evaluate their detergency-dispersancy and other properties. Comparison blends were made with succinimide additives based on the same ethylene oligomers. The Mannich bases give improvements in the oxidation resistance, anticorrosion properties, and detergency-dispersancy of the DS-11 diesel oil.

  9. Nuevos aspectos de la reacción tipo mannich en medio básico de 1,3,6,8-tetrazatriciclo[4.4.1.13,8] dodecano (tatd) con fenoles

    OpenAIRE

    Augusto Rivera; Jaime Rios Motta; Ariel Rodolfo Quevedo; Pedro Joseph Nathan

    2008-01-01

    Se ensayaron algunos fenoles como nucleófilos en la reacción tipo Mannich en medio básico frente al aminal macrocíclico1,3,6,8-tetrazatriciclo[4.4.1.1 3,8] dodecano (TATD). Dependiendo del grado de sustitución del fenol empleado, se obtuvieron:1,3- bis- [2’- hidroxibencil] imidazolidinas regioselectivamente, 2,6-di[3’-(2’’-hidroxibencil)-1’-metilenimidazolidin] fenoles y 3,3’-etilen-bis-(3,4-dihidro-2H- 1,3-benzoxazinas).

  10. Preparation and Properties of A Novel Modified Mannich Amine as Waterborne Epoxy Curing Agent%改性曼尼希胺水性环氧固化剂的制备及性能

    Institute of Scientific and Technical Information of China (English)

    李楚新; 段颖; 丁嘉欣; 夏新年

    2012-01-01

    A novel Modified Mannich Amine ( MAI ) was synthesized by amine exchange reaction using polyether amine (D -230) and DMP -30 as raw materials. A liquid epoxy resin (EP) and a homemade mono -functional epoxy polymer (PEG - EP) were used as chain extender for MAl's chain extension modifica tion, which was then terminated with phenyl glycidyl ether(PGE) to get Modified Mannich Amine(MA3). Finally, the Mannich amine waterborne epoxy curing agents ( CAs) were produced by phase - inversion e- mulsification method and used for waterborne epoxy resin. The influences of the PEG - EP amount, the feed ing ratio of MA1/EP and MAI/PEG on the stability of the dispersion were studied. The chemical structures and properties of the cured films were studied by physical chemistry method. The cured films of an optimiza tion system showed a hardness 229 s, flexibility 1 mm, adhesion 0 grade, pot ?life 5 h, and excellent water resistance.%以聚醚胺(D - 230)和DMP - 30为原料,利用胺交换反应制得一种新型的改性曼尼希胺(MAI).然后以自制的端官能环氧聚合物( PEG - EP)与低相对分子质量液体环氧树脂(EP)为扩链剂对MAI进行扩链改性,并用苯基缩水甘油醚(PGE)封端,最后采用相反转法制得了一种新型的改性曼尼希水性环氧固化剂.讨论了PEG - EP的添加量、MAI与EP的加料比及封端剂的添加量对水性固化剂体系稳定性的影响.并采用物理化学方法对反应程度及涂膜的性能进能了表征分析.优化体系固化涂膜硬度229s,柔韧性1mm,附着力0级,适用期5h,耐水性优异.

  11. 木质素模型化合物香草醛Mannich反应及其产物化学结构表征%Mannich Reaction of Lignin Model Compound Vanillin and Chemical Structure Characterization of Its Product

    Institute of Scientific and Technical Information of China (English)

    聂明才; 孔振武; 霍淑平; 吴国民; 陈健

    2012-01-01

    Vanillin aminated polyol(VAP) was prepared by vanillin, diethanolamine and paraformaldehyde in 1,4-dioxane by Mannich reaction. The effects of material ratio, reaction temperature, reaction time and solvent dosage on the Mannich reaction were investigated. It was observed the highest conversion rate of diethanolamine was up to 84.92 % by dropping 1,3-oxazolidine which was the reaction product of formaldehyde and diethanolamine at 60℃ for 2 h, into vanillin and reacting at 80 ℃ for 3 h in the molar ratio of n( vanillin) : n( formaldehyde) : n(diethanolamine) as 1 : 1 : 1 in 1,4-dioxane of 100 mL/mol vanillin. The chemical structure of vanillin aminated polyol was characterized by HPLC, LC-MS, FT-IR and 'H NMR, respectively.%以木质素模型化合物香草醛、二乙醇胺及多聚甲醛为原料,1,4-二氧杂环己烷为溶剂,通过Mannich反应合成了香草醛胺基多元醇,研究了物料配比、反应温度、时间及溶剂用量等因素对Mannich反应的影响.实验结果表明:反应物料按物质的量比n(香草醛):n(甲醛):n(二乙醇胺)1:1:1,甲醛与二乙醇胺60℃反应2h生成1,3-氧氮杂环戊烷,再将其滴入香草醛中,80℃反应3h,二氧六环溶剂用量为100 mL/mol(以香草醛的物质的量计),二乙醇胺的转化率最高可达到84.92%.采用HPLC、LC- MS、FT-IR及H NMR表征了香草醛胺基多元醇的化学结构,相对分子质量269.

  12. Synthesis and characterization of novel cardanol based benzoxazines.

    Science.gov (United States)

    Minigher, Andrea; Benedetti, Elena; De Giacomo, Ornela; Campaner, Pietro; Aroulmoji, Vincent

    2009-04-01

    Benzoxazines are a class of phenolic compounds extensively studied in polymer science because of their properties as fiber reinforcements, fire-retardants and curing agents. In this article is described a solvent-less process, based on a Mannich reaction involving a primary amine and an aldehyde, for the preparation of new benzoxazines deriving from cardanol (a well known phenol obtained as a renewable organic resource and harmful by-product of the cashew industry). Particular attention is given to the synthesis and chemical characterization (both by 1H NMR spectroscopy and HPLC), while the thermal polymerization process has been monitored by differential scanning calorimetry. PMID:19475998

  13. Evaluation of some Mannich bases derived from substituted acetophenones against P-388 lymphocytic leukemia and on respiration in isolated rat liver mitochondria.

    Science.gov (United States)

    Dimmock, J R; Shyam, K; Hamon, N W; Logan, B M; Raghavan, S K; Harwood, D J; Smith, P J

    1983-08-01

    Series of 3-dimethylamino-1-aryl-1-propanone hydrobromides (IV) and 3-dimethylamino-2-dimethylaminomethyl-1-aryl-1-propanone dihydrobromides (V) were synthesized. Evaluation of these derivatives against P-388 lymphocytic leukemia growth revealed that two compounds show promise as antineoplastic agents. Compounds of the V series were unstable in phosphate buffer (in contrast to series IV), and when the same nuclear substituent was present in both series of compounds, V was approximately 100 times more active than IV in both the stimulation and inhibition of respiration of mitochondria isolated from rat liver cells. Representatives from both series showed that respiration in mitochondria was affected by changing the pH of the aqueous buffer from 7.4 to 6.9 or 6.4 and by reducing the temperature from 37 degrees to 20 degrees. The compounds showed reactivity toward a biomimetic thiol. PMID:6620142

  14. A general strategy for the catalytic, highly enantio- and diastereoselective synthesis of indolizidine-based alkaloids.

    Science.gov (United States)

    Abels, Falko; Lindemann, Chris; Schneider, Christoph

    2014-02-10

    Sixteen indolizidine-based alkaloids (IBAs) that were isolated as poison constituents of the skin of frogs were synthesized in a highly flexible and stereoselective manner. As a key step, a three-component, organocatalytic, highly enantio- and diastereoselective vinylogous Mukaiyama-Mannich reaction was employed furnishing optically highly enriched butyrolactams as central intermediates on a multigram scale. The attached six-membered ring was constructed through cyclization of the pendant enoate moiety onto the pyrrolidine ring. The absolute configuration of the bridgehead chiral center and the adjacent 8-position was established in the initial vinylogous Mannich reaction, whereas the 3- and 5-substituents were introduced through organometallic addition at a late stage of the synthesis with full stereochemical control from the substrate. With this strategy, simple as well as even more complex alkaloids were accessible in good overall yields as single stereoisomers. These syntheses also served to establish the absolute and relative configuration of those IBAs that had never been synthesized before. PMID:24436076

  15. Synthesis and uranium adsorption performance of a novel modified lignin-based adsorbent

    International Nuclear Information System (INIS)

    The modified lignin-based adsorbent containing the strong-base and weak-base group, was prepared by two-step chemical modification of acid-precipitation lignin, which is low-cost, and abundant renewable natural polymers: (1) introduced weak-base group by mannich reaction; (2)introduced strong-base group by O-alkylatio reaction.The adsorbent was characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Elementary Analysis(EA), which demonstrated amino group was successfully introduced into the lignin. In order to assess the possibility of adsorption effect, the adsorption experiments of uranium on lignin-based adsorbent, were carried out in the static mode at room temperature. The removal rate of uranium of the wastewatere could reach 93%, under such conditions as pH value 2, uranium concentration 6 mg/L, and adsorbent dosage 10 g/L, etc. (authors)

  16. Synthesis and uranium adsorption performance of a novel modified lignin-based adsorbent

    International Nuclear Information System (INIS)

    The modified lignin-based adsorbent containing the strong-base and weak-base group, was prepared by two-step chemical modification of acid-precipitation lignin, which is a low-cost and abundant renewable natural polymer: 1) weak-base group introduced by Mannich reaction; 2) strong-base group introduced by O-alkylation reaction. The adsorbent was characterized by Fourier transform infrared spectroscopy (FT-IR) and elementary analysis (EA), which demonstrated amino group was successfully introduced into the lignin. In order to assess the adsorption effect, the uranium adsorption experiments of lignin-based adsorbent were carried out in the static mode at room temperature. The removal rate of uranium from the wastewater could reach 93% under such conditions as pH value 2, uranium concentration 6 mg/L, adsorbent dosage 10 g/L etc. (authors)

  17. Synthesis and uranium adsorption performance of a novel modified lign in-based adsorbent

    International Nuclear Information System (INIS)

    A novel modified lignin-based adsorbent containing the strong-base and weak-base group was prepared by two-steps chemical modification method using acid-precipitation lignin, which is low-cost and abundant renewable natural polymers: (1) introduced weak-base group by Mannich reaction; (2)introduced strong-base group by O-alkylation reaction. The adsorbent was characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Elementary Analysis (EA). The results indicated that two kinds of amino group were successfully introduced into the lignin structure. In order to assess its adsorption effect for uranyl, the adsorption experiments were carried out in the static mode at room temperature using a low-concentration uranium aqueous solution. The removal rate of uranium could reach 93%, under such conditions as pH value 2, uranium concentration 1-10 mg/L, and adsorbent dosage 10 g/L etc. (authors)

  18. 硫脲对腰果酚曼尼期碱固化与性能的影响%Effect of thiourea on the curing and properties of cardanol Mannich base

    Institute of Scientific and Technical Information of China (English)

    杨小华; 黄坤; 张燕; 夏建陵

    2014-01-01

    分别对环氧树脂(E-51)/腰果酚曼尼期碱(PCD)和环氧树脂(E-51)/硫脲改性腰果酚曼尼期碱(FC-D1)两种固化体系在不同温度下的凝胶时间进行了测定,通过Arrenhinus公式求出固化反应的表观活化能,并对固化物的力学性能和耐热性能进行了测试.结果表明:与E-51/PCD相比,E-51/FC-D1的表观活化能降低34.2%,低温固化反应活性更高,除固化物断裂伸长率下降46.9%外,其余剪切强度、拉伸强度、拉伸模量、弯曲强度、弯曲模量和压缩强度均得到提高,固化物综合性能好;耐热性基本保持不变.

  19. Synthesis of new 1H-1,2,3-triazole-1,4-naphthoquinones

    Directory of Open Access Journals (Sweden)

    Wagner O. Valença

    2012-06-01

    Full Text Available In this work, were synthesized new 1H-1,2,3-triazole-1,4-naphthoquinones via 1,3-dipolar cycloaddition reaction using CuI/acetonitrile without addition of base or ligand. The compounds (3a-i were obtained in moderate-to-good yields 45-92%. To prepare (3d, we obtain a mixture of (3d and (4 in a ratio 3:1, that it was difficult to separate. The low yield for the compound (3f can be also justified based in the formation of aminonaphthoquinone (4. The acetylation of (3h and (3i afforded the compounds (5 and (6 in 77% and 35% of yields, respectively. The low yield of (6 was due to formation of 35 % of the elimination product (7.

  20. Effect of Disposition of Mannich Antimalarial Agents on Their Pharmacology and Toxicology

    OpenAIRE

    Ruscoe, J. E.; Tingle, M. D.; O’Neill, P. M.; S.A. Ward; Park, B K

    1998-01-01

    The use of the antimalarial agent amodiaquine has been curtailed due to drug-induced idiosyncratic reactions. These have been attributed to the formation of a protein-reactive quinoneimine species via oxidation of the 4-aminophenol group. Therefore, the effects of chemical modifications on the disposition of amodiaquine in relation to its metabolism, distribution, and pharmacological activity have been investigated. The inclusion of a group at the C-5′ position of amodiaquine reduced or elimi...

  1. ALDOL- AND MANNICH-TYPE REACTIONS VIA IN SITU OLEFIN MIGRATION IN IONIC LIQUID. (R828129)

    Science.gov (United States)

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  2. Synthesis of some 1H-indole-2, 3-dione Derivatives as Antibacterial, Analgesic and Antiinflammatory Agents

    Directory of Open Access Journals (Sweden)

    Panda J 1,*

    2012-01-01

    Full Text Available The starting compound 1H-indole-2,3-dione on reaction with different substituted anilines formed the Schiff bases. The corresponding N-Mannich bases have been prepared by the reaction of the Schiff bases with diphenylamine in the presence of formaldehyde. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The synthesized Mannich bases were screened for their antibacterial, analgesic and anti-inflammatory activities by the standard methods. Among the tested compounds, the compound containing chloro group showed the most favorable activity.

  3. SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF VARIOUS PYRIDINE DERIVATIVES

    OpenAIRE

    Chaubey Ajit kumar; Pandeya S.N

    2011-01-01

    The treatment of 2-amino pyridine (1) with isatine (2) affords (3Z)-3-(pyridin-2-ylimino)-1,3-dihydro-2H-indol-2-one (3) & then treatment with formaldehyde along with secondary amine, various N-substituted of (3Z)-3-(pyridin-2-ylimino)-1,3-dihydro-2H-indol-2-one (Schiff base) in the presence of glacial acetic acid results Mannich bases (4-8). (3Z)-3-(pyridin-2-ylimino)-1,3-dihydro-2H-indol-2-one (3) were synthesized by refluxing (1-2) in glacial acetic acid.The Mannich bases (4-8) of above...

  4. Synthesis and Antifungal Evaluation of 1-Aryl-2-dimethyl-aminomethyl-2-propen-1-one Hydrochlorides

    Directory of Open Access Journals (Sweden)

    Mehmet Emin Topaloglu

    2011-06-01

    Full Text Available The development of resistance to current antifungal therapeutics drives the search for new effective agents. The fact that several acetophenone-derived Mannich bases had shown remarkable antifungal activities in our previous studies led us to design and synthesize some acetophenone-derived Mannich bases, 1-8 and 2-acetylthiophene-derived Mannich base 9, 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochloride, to evaluate their antifungal activities. The designed chemical structures have α,β-unsaturated ketone moieties, which are responsible for the bioactivities of the Mannich bases. The aryl part was C6H5 (1; 4-CH3C6H4 (2; 4-CH3OC6H4 (3; 4-ClC6H4 (4; 4-FC6H4 (5; 4-BrC6H4 (6; 4-HOC6H4 (7; 4-NO2C6H4 (8; and C4H3S(2-yl (9. In this study the designed compounds were synthesized by the conventional heating method and also by the microwave irradiation method to compare these methods in terms of reaction times and yields to find an optimum synthetic method, which can be applied for the synthesis of Mannich bases in further studies. Since there are limited number of studies reporting the synthesis of Mannich bases by microwave irradiation, this study may also contribute to the general literature on Mannich bases. Compound 7 was reported for the first time. Antifungal activities of all compounds and synthesis of the compounds by microwave irradiation were also reported for the first time by this study. Fungi (15 species were used for antifungal activity test. Amphotericin B was tested as an antifungal reference compound. In conclusion, compounds 1-6, and 9, which had more potent (2–16 times antifungal activity than the reference compound amphotericin B against some fungi, can be model compounds for further studies to develop new antifungal agents. In addition, microwave irradiation can be considered to reduce reaction period, while the conventional method can still be considered to obtain compounds with higher reaction yields in the synthesis of

  5. Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation

    Directory of Open Access Journals (Sweden)

    Manav Malhotra

    2014-11-01

    Full Text Available In this study a series of new mannich bases were synthesized and characterized by elemental and spectral (IR, 1H NMR, 13C NMR studies. All the synthesized compounds were evaluated for their antimicrobial activity by broth dilution method against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa, two Gram positive strains (Bacillus subtilis and Staphylococcus aureus and fungal strain (Candida albicans and Aspergillus niger. Preliminary pharmacological evaluation revealed that the compounds (3f, 3i, 3j, and 3k showed good activity against these strains. The result demonstrates the potential and importance of developing new mannich bases which would be effective against resistant bacterial and fungal strain.

  6. Synthesis of 3H and 14C labelled changrolin

    International Nuclear Information System (INIS)

    3 kinds of [14C] and [3H] changrolin labelled at different positions (I, II, III) were prepared. The synthesis of I is as follows: (Scheme 1): Heating 5-bromoanthranilic acid with formamide yielded IV, which on heating with POCl3 gave V. Condensation of V with 4-aminophenol and Mannich reaction produced 6-bromochangrolin (VI). Catalytic dehalogenation of VI with tritium gas gave I. The synthesis of II was started from (14C) formamide and anthranilic acid. Labelled 4-chloroquine obtained was condensed with Mannich base (VII) directly (Scheme 2). III was prepared by 1 step with (14C) formaldehyde (Scheme 1)

  7. 2,2'-[1,3-Diazinane-1,3-diylbis(methylene)]bis(4-bromophenol)

    Czech Academy of Sciences Publication Activity Database

    Rivera, A.; Trujillo, G.P.; Ríos-Motta, J.; Fejfarová, Karla; Dušek, Michal

    2012-01-01

    Roč. 68, č. 2 (2012), "O498"-"U1493". ISSN 1600-5368 Grant ostatní: AV ČR(CZ) Praemium Academiae Institutional research plan: CEZ:AV0Z10100521 Keywords : Mannich bases * crystal structure * X-ray diffraction * Jana2006 Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.347, year: 2011

  8. Synthesis of N1-Substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyra- zolethiocarboxamide as Novel Small Molecule Inhibitors of Cysteine Protease of T. cruzi

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine protease of T.cruzi..

  9. Di-n-butyl 4,4´-dihydroxy-3,3´-{[(3aRS,7aRS )-2,3,3a,4,5,6,7,7a-octahydro-1H -1,3-benzimidazole-1,3-diyl]bis(methylene)}dibenzoate

    Czech Academy of Sciences Publication Activity Database

    Rivera, A.; Quiroga, D.; Ríos-Motta, J.; Fejfarová, Karla; Dušek, Michal

    2011-01-01

    Roč. 67, Part 9 (2011), o2297-u2304. ISSN 1600-5368 Grant ostatní: AVČR(CZ) Praemium Academiae Institutional research plan: CEZ:AV0Z10100521 Keywords : Mannich bases * crystal structure * X-ray diffraction Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.347, year: 2011

  10. New lab-made coagulant based on Schinopsis balansae tannin extract: synthesis optimization and preliminary tests on refractory water pollutants

    Science.gov (United States)

    Sánchez-Martín, J.; Beltrán-Heredia, J.; Coco-Rivero, B.

    2014-09-01

    Quebracho colorado tannin extract was used as a coagulant raw material for water and wastewater treatment. The chemical synthesis follows a Mannich reaction mechanism and provides a fully working coagulant that can remove several pollutants from water. This paper addresses the optimization of such synthesis and confirms the feasibility of the coagulant by testing it in a preliminary screening for the elimination of dyes and detergents. The optimum combination of reagents was 6.81 g of diethanolamine (DEA) and 2.78 g of formaldehyde (F) per g of tannin extract. So obtained coagulant was succesfully tested on the removal of 9 dyes and 8 detergents.

  11. RUTHENIUM-CATALYZED TANDEM OLEFIN MIGRATION-ALDOL AND MANNICH-TYPE REACTIONS IN WATER AND PROTIC SOLVENT. (R828129)

    Science.gov (United States)

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  12. Radioprotector and antineoplastic activity of certain tetrazole derivatives

    International Nuclear Information System (INIS)

    For a modification of the biological activity of the 5-substituted tetrazoles that were studied earlier, the authors synthesized products of their alkylation by Mannich bases from phenols, since substances with good radioprotective properties have been detected among the phenols. The acute toxicity was determined on mice and treatment of the data on toxicity of the compounds studied was performed according to the method of Litchfield and Wilcoson, and LD16, LD50, and LD84 were determined

  13. Kinetic evidence of an apparent negative activation enthalpy in an organocatalytic process

    KAUST Repository

    Han, Xiao

    2013-08-30

    A combined kinetic and computational study on our tryptophan-based bifunctional thiourea catalyzed asymmetric Mannich reactions reveals an apparent negative activation enthalpy. The formation of the pre-transition state complex has been unambiguously confirmed and these observations provide an experimental support for the formation of multiple hydrogen bonding network between the substrates and the catalyst. Such interactions allow the creation of a binding cavity, a key factor to install high enantioselectivity.

  14. SYNTHESIS OF 1-({7-METHOXY-2-[4-(METHYLSULFANYL PHENYL]-1- BENZOFURAN-5-YL}-N-[(N-ETHYLPYRROLIDIN-2-YL METHYL]METHANAMINE BY REDUCTIVE AMINATION. Synthese von 1 - ({7-methoxy-2-[4 - (methylsulfanyl phenyl] -1 - BENZOFURAN-5-yl}-N-[(N-Ethylpyrrolidin-2-yl methyl] MethanaMine Durch reduktive LAMINATION.

    Directory of Open Access Journals (Sweden)

    Bapu R Thorata, Dyneshwar Shelke, Ramdas Atram and Ramesh Yamgar

    2013-07-01

    Full Text Available Vanillin undergoes sequence of reaction forming phosphonium salt through dimethyaminomethyl derivative (Mannich reaction. The synthesis of phosphonium salt can be achieved by sequence of three steps. A solution of Mannich base in acetic anhydride was refluxed for 24 hrs to give crude diacetate which is purified and treated with HCl to give chloromethyl derivative. It is further treated with triphenylphosphine in dry benzene under reflux condition. The phosphonium salt undergoes condensation with 4-methylsulfanylbenzoyl chloride by refluxing in toluene in presence of triethylamine. The reaction was completed in 6 hrs. The crude product was purified by using column chromatography. The resulting 7-methoxy-2-[4- (methylsulfanylphenyl]-l-benzofuran-5-carboxaldehyde was subjected to reductive amination and the final product 1-({7-methoxy-2-[4-(methylsulfanylphenyl]-1-benzofuran-5-yl}-N-[(Nethylpyrrolidin- 2-ylmethyl]methan amine was purified by column chromatography and characterized by FT-IR, NMR and Mass spectroscopy.

  15. Touch BASE

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    In a recent Nature article (see here), the BASE collaboration reported the most precise comparison of the charge-to-mass ratio of the proton to its antimatter equivalent, the antiproton. This result is just the beginning and many more challenges lie ahead.   CERN's AD Hall, where the BASE experiment is set-up. The Baryon Antibaryon Symmetry Experiment (BASE) was approved in June 2013 and was ready to take data in August 2014. During these 14 months, the BASE collaboration worked hard to set up its four cryogenic Penning traps, which are the heart of the whole experiment. As their name indicates, these magnetic devices are used to trap antiparticles – antiprotons coming from the Antiproton Decelerator – and particles of matter – negative hydrogen ions produced in the system by interaction with a degrader that slows the antiprotons down, allowing scientists to perform their measurements. “We had very little time to set up the wh...

  16. Monetary base

    OpenAIRE

    Richard G. Anderson

    2006-01-01

    This brief essay is a working draft of an article in preparation for the forthcoming International Encyclopedia of the Social Sciences, 2nd ed., examining the role of the monetary base in monetary economics and monetary policymaking. Comments are welcome.

  17. Web based foundry knowledge base

    Directory of Open Access Journals (Sweden)

    A. Stawowy

    2009-01-01

    Full Text Available The main assumptions and functions of proposed Foundry Knowledge Base (FKB are presented in this paper. FKB is a framework forinformation exchange of casting products and manufacturing methods. We use CMS (Content Management System to develope andmaintain our web-based system. The CastML – XML dialect developed by authors for description of casting products and processes – isused as a tool for information interchange between ours and outside systems, while SQL is used to store and edit knowledge rules and alsoto solve the basic selection problems in the rule-based module. Besides the standard functions (companies data, news, events, forums and media kit, our website contains a number of nonstandard functions; the intelligent search module based on expert system is the main advantage of our solution. FKB is to be a social portal which content will be developed by foundry community.

  18. Application of an ortho-Formylation Reaction in One-pot Procedures and Natural Product Syntheses

    OpenAIRE

    2009-01-01

    This thesis describes the transformation of phenols into ortho-hydroxycinnamates, salicylamines, benzoxazines, and salicylnitriles in good overall yields by simple, regioselective, and one-pot procedures using a combination of MgCl2-Et3N as a base system. These one-pot processes are more economically and environmentally benign than those methods previously reported. The MgCl2-Et3N base system was also used in a regioselective Mannich reaction. Moreover, the first total synthesis of (±)-pow...

  19. Unified Synthesis of 10-Oxygenated Lycopodium Alkaloids: Impact of C10-Stereochemistry on Reactivity.

    Science.gov (United States)

    Saha, Mrinmoy; Li, Xin; Collett, Nathan D; Carter, Rich G

    2016-07-15

    The pronounced impact of the C10 stereochemistry on the successful construction of a polycyclic Lycopodium alkaloid scaffold has been explored. A wide range of reaction conditions and functionality were investigated to control a keto sulfone Michael addition to construct the C7-C12 linkage. An unexpected, overriding impact of the C10 stereochemistry in stereoselectivity and reaction rate in the Michael addition was observed. Furthermore, divergent reactivity of a conformationally accelerated, intramolecular Mannich cyclization based on the C10 stereochemistry was discovered. The successful execution of this synthetic route resulted in the total synthesis of all three known 10-oxygenated Lycopodium alkaloids: 10-hydroxylycopodine, paniculine, and deacetylpaniculine. PMID:27353498

  20. Crystal Structure and Electrospray Mass Spectrum of Tris(2,5-dioxopyrrolidin-1-ylmethyl) amine

    Institute of Scientific and Technical Information of China (English)

    ZHENG,Xiang-Jun(郑向军); ZHENG,Xiang-Jun; JIN,Lin-Pei (金林培); JIN,Lin-Pei; GUO,Jian-Quan(郭建权); GUO,Jian-Quan; ZHUANG,Jin-You(庄锦幼); ZHUANG,Jin-You; ZHU,Long-Gen(朱龙根); ZHU,Long-Gen; MEI,Yu-Hua(梅毓华); MEI,Yu-Hua

    2001-01-01

    A novel N-Mannich base tris(2,5-dioxopyrrolidin-1-ylmethyl)-amine(TDOPMA)was synthesized and its structure was determined by single crystal X-ray diffraction.Unlike NH3 molecule,three C-N-C bond angles containing the central N atom in the title compound are unequal and about 9° larger than H-N-H angles of NH3 molecule.Electrospray ionization (ESI)mass spectrometry was applied to the title compound.Its fragments were interpreted and possible fragmentation mechanism was given.

  1. Nuevos aspectos de la reacción entre el aminal macrocíclico 1:3,7:9,13:15,19:21-tetrametilentetrahexahidropirimidina (TMTP) frente a fenoles p-halogenados en condiciones “solvent free”

    OpenAIRE

    Trujillo Pérez, Ginna Paola

    2012-01-01

    Los estudios del aminal macrocíclico 1 (TATD) frente a fenoles en medio básico han demostrado que en esta reacción es posible obtener, de manera orto-regioselectiva bases tipo Mannich como 1,3-bis-[2´hidroxi-5´sustituidas bencil]imidazolidinas BISBIAS 4,1 compuestos que presentan gran importancia sintética debido a la amplia variedad de productos obtenidos a partir de sus reacciones. 2 Teniendo en cuenta el comportamiento químico de 1 frente a fenoles, se estudió la reactividad de un amina...

  2. Crystal structure of 1-[(2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazin-2-yl)methyl]naphthalen-2-ol: a possible candidate for new polynaphthoxazine materials

    OpenAIRE

    Augusto Rivera; Jicli José Rojas; Jaime Ríos-Motta; Michael Bolte

    2015-01-01

    In the title compound, C23H19NO2, an oxazine Mannich base derivative, the oxazine ring has a half-chair conformation. The 2-hydroxynaphthalen-1-yl substituent is placed in an axial position. There is an intramolecular O—H...N hydrogen bond, forming an S(6) graph-set motif. In the crystal, molecules are connected by a pair of C—H...π interactions into an inversion dimer, which is reinforced by another pair of weak C—H...π interactions. The dimers are linked by a π–π interaction [centroid-centr...

  3. Foundation: Transforming data bases into knowledge bases

    Science.gov (United States)

    Purves, R. B.; Carnes, James R.; Cutts, Dannie E.

    1987-01-01

    One approach to transforming information stored in relational data bases into knowledge based representations and back again is described. This system, called Foundation, allows knowledge bases to take advantage of vast amounts of pre-existing data. A benefit of this approach is inspection, and even population, of data bases through an intelligent knowledge-based front-end.

  4. INVOLUTIVE BASES UNDER COMPOSITION

    Institute of Scientific and Technical Information of China (English)

    Zailiang TANG

    2007-01-01

    In this paper, the behaviors of involutive bases under composition operation are studied.For two kinds of involutive bases, i.e., Pommaret bases, Janet bases, we study their behavior problems under composition. Some further problems are also proposed.

  5. A dynamic knowledge base based search engine

    Institute of Scientific and Technical Information of China (English)

    WANG Hui-jin; HU Hua; LI Qing

    2005-01-01

    Search engines have greatly helped us to find thedesired information from the Intemet. Most search engines use keywords matching technique. This paper discusses a Dynamic Knowledge Base based Search Engine (DKBSE), which can expand the user's query using the keywords' concept or meaning. To do this, the DKBSE needs to construct and maintain the knowledge base dynamically via the system's searching results and the user's feedback information. The DKBSE expands the user's initial query using the knowledge base, and returns the searched information after the expanded query.

  6. In vivo pharmacokinetic studies of prodrugs of ibuprofen

    Directory of Open Access Journals (Sweden)

    Doshi Abha

    2007-01-01

    Full Text Available In vivo pharmacokinetic studies of N-Mannich base derivatives of ibuprofenamide as prodrugs were performed on rabbits. Ibuprofen and both the prodrugs (IBMB-M and IBMB-P were administered orally and at different time intervals blood samples were collected and assayed for ibuprofen and ibuprofenamide by HPLC method. From the plasma concentration-time profile; (C p max , t max , AUC and the time required to achieve minimum effective concentration were calculated. N-Mannich base prodrugs first get hydrolyzed to ibuprofenamide which in turn gets hydrolyzed to ibuprofen by the enzyme amidase. The (C p max and AUC values of IBMB-M were found to be more compared to IBMB-P. In both the cases ibuprofen started appearing after 2 h and it required minimum 4 h to get the ibuprofen in therapeutic range. Both the prodrugs released ibuprofen slowly which gave sustained effect. IBMB-M provided ibuprofen in therapeutic range for 48 h and IBMB-P for 24 h.

  7. Knowledge Based Strategies for Knowledge Based Organizations

    Directory of Open Access Journals (Sweden)

    Madalina Cristina Tocan

    2012-12-01

    Full Text Available In the present, we can observe that a new economy is arising. It is an economy based on knowledge and ideas, in which the key factor for prosperity and for creation of the new jobs is the knowledge capitalization. Knowledge capitalization, intellectual capital, obtaining prosperity in the market economy imposes a new terminology, new managerial methods and techniques, new technologies and also new strategies. In other words, knowledge based economy, as a new type of economy; impose a new type of management- knowledge based management and a new type of enterprise-knowledge based enterprise.Taking in consideration these predictable evolutions, this paper will try to present: • The main ideas of the researches the field of the knowledge based economy • The characteristics and principles of the knowledge based organizations and knowledge based management • The challenges and opportunities for knowledge based organizations.The first part of the paper will present the principles of the new economy- knowledge base economy, the essential and interrelated elements necessary to build and to implement a strategy in a knowledge economy and the opportunities and challenges to the countries as they seek to build regionally and globally competitive knowledge-based economies.The second part of the paper will present the characteristics of the knowledge based organizations, the principles and characteristics of their management. For many organizations, knowledge management is a relatively new concept, because they are discovering the knowledge value in their operations. Many firms have undertaken formal and informal knowledge management initiatives designed to improve process performance, increase customer responsiveness and spur innovation. But while some organizations have reaped significant benefits from their investment in knowledge efforts, others have run into noteworthy challenges.

  8. Team-Based Learning

    Science.gov (United States)

    Michaelsen, Larry K.; Sweet, Michael

    2011-01-01

    Team-based learning (TBL), when properly implemented, includes many, if not all, of the common elements of evidence-based best practices. To explain this, a brief overview of TBL is presented. The authors examine the relationship between the best practices of evidence-based teaching and the principles that constitute team-based learning. (Contains…

  9. Solid Base Catalysis

    CERN Document Server

    Ono, Yoshio

    2011-01-01

    The importance of solid base catalysts has come to be recognized for their environmentally benign qualities, and much significant progress has been made over the past two decades in catalytic materials and solid base-catalyzed reactions. The book is focused on the solid base. Because of the advantages over liquid bases, the use of solid base catalysts in organic synthesis is expanding. Solid bases are easier to dispose than liquid bases, separation and recovery of products, catalysts and solvents are less difficult, and they are non-corrosive. Furthermore, base-catalyzed reactions can be performed without using solvents and even in the gas phase, opening up more possibilities for discovering novel reaction systems. Using numerous examples, the present volume describes the remarkable role solid base catalysis can play, given the ever increasing worldwide importance of "green" chemistry. The reader will obtain an overall view of solid base catalysis and gain insight into the versatility of the reactions to whic...

  10. Case Base Maintenance Approach.

    OpenAIRE

    Haouchine, Mohamed-Karim; Chebel-Morello, Brigitte; Zerhouni, Noureddine

    2007-01-01

    Case base Maintenance is an active Case Based Reasoning research area. The main stream focuses on the method for reducing the size of the case-base while maintaining case-base competence. This paper gives an overview of these works, and proposes a case deletion strategy based on competence criteria using a novel approach. The proposed method, even if inspired from existing literature, combines an algorithm with a Competence Metric (CM). A series of tests are conducted using two standards data...

  11. Knowledge Based Strategies for Knowledge Based Organizations

    OpenAIRE

    Madalina Cristina Tocan

    2012-01-01

    In the present, we can observe that a new economy is arising. It is an economy based on knowledge and ideas, in which the key factor for prosperity and for creation of the new jobs is the knowledge capitalization. Knowledge capitalization, intellectual capital, obtaining prosperity in the market economy imposes a new terminology, new managerial methods and techniques, new technologies and also new strategies. In other words, knowledge based economy, as a new type of economy; impose a new type...

  12. VectorBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — VectorBase is a Bioinformatics Resource Center for invertebrate vectors. It is one of four Bioinformatics Resource Centers funded by NIAID to provide web-based...

  13. Beyond Zero Based Budgeting.

    Science.gov (United States)

    Ogden, Daniel M., Jr.

    1978-01-01

    Suggests that the most practical budgeting system for most managers is a formalized combination of incremental and zero-based analysis because little can be learned about most programs from an annual zero-based budget. (Author/IRT)

  14. Mobile Inquiry Based Learning

    NARCIS (Netherlands)

    Specht, Marcus

    2012-01-01

    Specht, M. (2012, 8 November). Mobile Inquiry Based Learning. Presentation given at the Workshop "Mobile inquiry-based learning" at the Mobile Learning Day 2012 at the Fernuniversität Hagen, Hagen, Germany.

  15. "Education-based Research"

    DEFF Research Database (Denmark)

    Degn Johansson, Troels

    This paper lays out a concept of education-based research-the production of research knowledge within the framework of tertiary design education-as an integration of problem-based learning and research-based education. This leads to a critique of reflective practice as the primary way to facilitate...... learning at this level, a discussion of the nature of design problems in the instrumentalist tradition, and some suggestions as to how design studies curricula may facilitate education-based research....

  16. The ground based plan

    International Nuclear Information System (INIS)

    The paper presents a report of ''The Ground Based Plan'' of the United Kingdom Science and Engineering Research Council. The ground based plan is a plan for research in astronomy and planetary science by ground based techniques. The contents of the report contains a description of:- the scientific objectives and technical requirements (the basis for the Plan), the present organisation and funding for the ground based programme, the Plan, the main scientific features and the further objectives of the Plan. (U.K.)

  17. Problem Based Learnig

    OpenAIRE

    Kolmos, Anette; Kuru, Selahattin; Hansen, Hans; Eskil, Taner; Podesta, Luca; Fink, Flemming; Graaff, Erik de; Uwe Wolff, Jan; Soylu, Ahmet

    2007-01-01

    This report discuss Problem-Based and Project-Based Learning (PBL) as an approach to meeting the demand for the educational requirements of the next generation engineering graduates. The report is prepared as the final report of the Special Interest Group (SIG) B5 of the Erasmus Thematic Network Project TREE (Teaching and Research in Engineering Education) on Problem- Based and Project-Based Learning. In engineering education there is a shift in emphasis from professional skill...

  18. Stolen Base Physics

    Science.gov (United States)

    Kagan, David

    2013-01-01

    Few plays in baseball are as consistently close and exciting as the stolen base. While there are several studies of sprinting, the art of base stealing is much more nuanced. This article describes the motion of the base-stealing runner using a very basic kinematic model. The model will be compared to some data from a Major League game. The…

  19. Convergent Filter Bases

    OpenAIRE

    Coghetto Roland

    2015-01-01

    We are inspired by the work of Henri Cartan [16], Bourbaki [10] (TG. I Filtres) and Claude Wagschal [34]. We define the base of filter, image filter, convergent filter bases, limit filter and the filter base of tails (fr: filtre des sections).

  20. Weak mutually unbiased bases

    International Nuclear Information System (INIS)

    Quantum systems with variables in Z(d) are considered. The properties of lines in the Z(d)xZ(d) phase space of these systems are studied. Weak mutually unbiased bases in these systems are defined as bases for which the overlap of any two vectors in two different bases is equal to d−1/2 or alternatively to one of the d−1/2i, 0 (where di is a divisor of d apart from d, 1). They are designed for the geometry of the Z(d)xZ(d) phase space, in the sense that there is a duality between the weak mutually unbiased bases and the maximal lines through the origin. In the special case of prime d, there are no divisors of d apart from 1, d and the weak mutually unbiased bases are mutually unbiased bases. (fast track communication)

  1. Search Based Software Engineering

    OpenAIRE

    Jaspreet Bedi; Kuljit Kaur

    2014-01-01

    This paper reviews the search based software engineering research and finds the major milestones in this direction. The SBSE approach has been the topic of several surveys and reviews. Search Based Software Engineering (SBSE) consists of the application of search-based optimization to software engineering. Using SBSE, a software engineering task is formulated as a search problem by defining a suitable candidate solution representation and a fitness function to differentiate be...

  2. Case-based reasoning

    CERN Document Server

    Kolodner, Janet

    1993-01-01

    Case-based reasoning is one of the fastest growing areas in the field of knowledge-based systems and this book, authored by a leader in the field, is the first comprehensive text on the subject. Case-based reasoning systems are systems that store information about situations in their memory. As new problems arise, similar situations are searched out to help solve these problems. Problems are understood and inferences are made by finding the closest cases in memory, comparing and contrasting the problem with those cases, making inferences based on those comparisons, and asking questions whe

  3. XML-BASED REPRESENTATION

    Energy Technology Data Exchange (ETDEWEB)

    R. KELSEY

    2001-02-01

    For focused applications with limited user and use application communities, XML can be the right choice for representation. It is easy to use, maintain, and extend and enjoys wide support in commercial and research sectors. When the knowledge and information to be represented is object-based and use of that knowledge and information is a high priority, then XML-based representation should be considered. This paper discusses some of the issues involved in using XML-based representation and presents an example application that successfully uses an XML-based representation.

  4. Gasification-based biomass

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2009-01-18

    The gasification-based biomass section of the Renewable Energy Technology Characterizations describes the technical and economic status of this emerging renewable energy option for electricity supply.

  5. Monitoring Knowledge Base (MKB)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Monitoring Knowledge Base (MKB) is a compilation of emissions measurement and monitoring techniques associated with air pollution control devices, industrial...

  6. Guarded Hybrid Knowledge Bases

    CERN Document Server

    Heymans, Stijn; Predoiu, Livia; Feier, Cristina; Van Nieuwenborgh, Davy

    2007-01-01

    Recently, there has been a lot of interest in the integration of Description Logics and rules on the Semantic Web.We define guarded hybrid knowledge bases (or g-hybrid knowledge bases) as knowledge bases that consist of a Description Logic knowledge base and a guarded logic program, similar to the DL+log knowledge bases from (Rosati 2006). G-hybrid knowledge bases enable an integration of Description Logics and Logic Programming where, unlike in other approaches, variables in the rules of a guarded program do not need to appear in positive non-DL atoms of the body, i.e. DL atoms can act as guards as well. Decidability of satisfiability checking of g-hybrid knowledge bases is shown for the particular DL DLRO, which is close to OWL DL, by a reduction to guarded programs under the open answer set semantics. Moreover, we show 2-EXPTIME-completeness for satisfiability checking of such g-hybrid knowledge bases. Finally, we discuss advantages and disadvantages of our approach compared with DL+log knowledge bases.

  7. BIOMETRICS BASED USER AUTHENTICATION

    OpenAIRE

    Tanuj Tiwari; Tanya Tiwari2; Sanjay Tiwari

    2015-01-01

    Biometrics is automated methods of recognizing a person based on a physiological or behavioral characteristic. Biometrics technologies are base for a plethora of highly secure identification and personal verification solutions. It is measurement of biological characteristics – either physiological or behavioral – that verify the claimed identity of an individual. Physiological biometrics include fingerprints, iris recognition. voice verification, retina recognition, palm vein patt...

  8. Model-based geostatistics

    CERN Document Server

    Diggle, Peter J

    2007-01-01

    Model-based geostatistics refers to the application of general statistical principles of modeling and inference to geostatistical problems. This volume provides a treatment of model-based geostatistics and emphasizes on statistical methods and applications. It also features analyses of datasets from a range of scientific contexts.

  9. Evidence based practice

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2011-01-01

    Evidence-based practice (EBP) is an influential interdisciplinary movement that originated in medicine as evidence-based medicine (EBM) about 1992. EBP is of considerable interest to library and information science (LIS) because it focuses on a thorough documentation of the basis for the decision...

  10. Arkansas' Disappearing Tax Base.

    Science.gov (United States)

    Schoppmeyer, Martin; Venters, Tommy

    State legislation that has contributed to the reduction of Arkansas' tax base is described in this paper. Amendment 59, adopted in 1980, has reduced the state tax base by millions of dollars. At the end of 1992, the majority of school districts have equalized their real, personal, and carrier and utility property. Act 34, the current foundation…

  11. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Fogh Olsen, Ole; Sporring, Jon

    2007-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination...... features, while eliminating noise. We call our method diffusion based photon mapping....

  12. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Olsen, Ole Fogh; Sporring, Jon

    2006-01-01

    . To address this problem we introduce a novel photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way we preserve the important illumination...... features, while eliminating noise. We call our method diffusion based photon mapping....

  13. Zero-Based Budgeting.

    Science.gov (United States)

    Wichowski, Chester

    1979-01-01

    The zero-based budgeting approach is designed to achieve the greatest benefit with the fewest undesirable consequences. Seven basic steps make up the zero-based decision-making process: (1) identifying program goals, (2) classifying goals, (3) identifying resources, (4) reviewing consequences, (5) developing decision packages, (6) implementing a…

  14. Hydrogel based occlusion systems

    NARCIS (Netherlands)

    Stam, F.A.; Jackson, N.; Dubruel, P.; Adesanya, K.; Embrechts, A.; Mendes, E.; Neves, H.P.; Herijgers, P.; Verbrugghe, Y.; Shacham, Y.; Engel, L.; Krylov, V.

    2013-01-01

    A hydrogel based occlusion system, a method for occluding vessels, appendages or aneurysms, and a method for hydrogel synthesis are disclosed. The hydrogel based occlusion system includes a hydrogel having a shrunken and a swollen state and a delivery tool configured to deliver the hydrogel to a tar

  15. Game-Based Teaching

    DEFF Research Database (Denmark)

    Hanghøj, Thorkild

    2013-01-01

    This chapter outlines theoretical and empirical perspectives on how Game-Based Teaching can be integrated within the context of formal schooling. Initially, this is done by describing game scenarios as models for possible actions that need to be translated into curricular knowledge practices...... approaches to game-based teaching, which may or may not correspond with the pedagogical models of particular games....

  16. Secure base stations

    NARCIS (Netherlands)

    Bosch, Peter; Brusilovsky, Alec; McLellan, Rae; Mullender, Sape; Polakos, Paul

    2009-01-01

    With the introduction of the third generation (3G) Universal Mobile Telecommunications System (UMTS) base station router (BSR) and fourth generation (4G) base stations, such as the 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) Evolved Node B (eNB), it has become important to se

  17. Bases de dades relacionals

    OpenAIRE

    Villegas González, Daniel

    2016-01-01

    Les empreses de reclutament de personal han d¿afrontar una sèrie de reptes per les seves tasques diàries, pel gran volum de candidats per cobrir les necessitats del mercat de llocs de treball. RecruitCAT és una empresa de reclutament de personal que necessita gestionar la seva base de dades. El objectiu és dissenyar i implementar una base de dades per gestionar una empresa de reclutament de personal, assolint les tasques d¿estudi, plantejament teòric i els scripts de generació de la base d...

  18. Profile Based Information Retrieval

    Directory of Open Access Journals (Sweden)

    Athar shaikh,

    2011-04-01

    Full Text Available This paper present Profile Based information retrieval system(PBIR. This system provide the user to register with it and based on the users registered areas of interest the system searches the related and efficient information form the world wide web using the technique of web text mining and arranges the unstructured data into structured format and present it to the user. This system also stores the previously searched data and based on users areas of interest and rating awarded to the interest by the user his profile will be updated at particular scheduled time.

  19. CLOUD COMPUTING BASED ORIENTATION

    OpenAIRE

    K. Jithendar; K.Srujan Raju; K. Neeraja

    2013-01-01

    With the rapid increase in the technology internet plays a major role in the society with the existence of the cloud based scenario. Where it is very much useful in the technology based on information related to the software oriented approach. It is mainly concerned about the utilities of the system which is the primary goal. It play a key role in the transmission of the data with a high definition oriented security based analysis respectively. Therefore whenever the user in the form of the c...

  20. Data base management study

    Science.gov (United States)

    1976-01-01

    Data base management techniques and applicable equipment are described. Recommendations which will assist potential NASA data users in selecting and using appropriate data base management tools and techniques are presented. Classes of currently available data processing equipment ranging from basic terminals to large minicomputer systems were surveyed as they apply to the needs of potential SEASAT data users. Cost and capabilities projections for this equipment through 1985 were presented. A test of a typical data base management system was described, as well as the results of this test and recommendations to assist potential users in determining when such a system is appropriate for their needs. The representative system tested was UNIVAC's DMS 1100.

  1. QuickBase

    CERN Document Server

    Conner, Nancy

    2007-01-01

    Ready to put Intuit's QuickBase to work? Our new Missing Manual shows you how to capture, modify, share, and manage data and documents with this web-based data-sharing program quickly and easily. No longer do you have to coordinate your team through a blizzard of emails or play frustrating games of "guess which document is the right one."QuickBase saves your organization time and money, letting you manage and share the information that makes your business tick: sales figures, project timelines, drafts of documents, purchase or work requests--whatever information you need to keep business flowi

  2. Lidar base specification

    Science.gov (United States)

    Heidemann, Hans Karl.

    2012-01-01

    In late 2009, a $14.3 million allocation from the “American Recovery and Reinvestment Act” for new light detection and ranging (lidar) elevation data prompted the U.S. Geological Survey (USGS) National Geospatial Program (NGP) to develop a common base specification for all lidar data acquired for The National Map. Released as a draft in 2010 and formally published in 2012, the USGS–NGP “Lidar Base Specification Version 1.0” (now Lidar Base Specification) was quickly embraced as the foundation for numerous state, county, and foreign country lidar specifications.

  3. Biometric-based Technologies

    OpenAIRE

    OECD

    2004-01-01

    This report is intended to provide an understanding of the benefits and limitations of biometric-based technologies. It also includes information on existing privacy and security methodologies for assessing biometrics.

  4. Cheboygan Vessel Base

    Data.gov (United States)

    Federal Laboratory Consortium — Cheboygan Vessel Base (CVB), located in Cheboygan, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). CVB was established by congressional...

  5. Problem Based Learning

    DEFF Research Database (Denmark)

    de Graaff, Erik; Guerra, Aida

    Problem-Based Learning (PBL) is an innovative method to organize the learning process in such a way that the students actively engage in finding answers by themselves. During the past 40 years PBL has evolved and diversified resulting in a multitude in variations in models and practices. However...... model and in general problem based and project based learning. We apply the principle of teach as you preach. The poster aims to outline the visitors’ workshop programme showing the results of some recent evaluations......., the key principles remain the same everywhere. Graaff & Kolmos (2003) identify the main PBL principles as follows: 1. Problem orientation 2. Project organization through teams or group work 3. Participant-directed 4. Experiental learning 5. Activity-based learning 6. Interdisciplinary learning and 7...

  6. Noncommutative Involutive Bases

    CERN Document Server

    Evans, G A

    2006-01-01

    The theory of Groebner Bases originated in the work of Buchberger and is now considered to be one of the most important and useful areas of symbolic computation. A great deal of effort has been put into improving Buchberger's algorithm for computing a Groebner Basis, and indeed in finding alternative methods of computing Groebner Bases. Two of these methods include the Groebner Walk method and the computation of Involutive Bases. By the mid 1980's, Buchberger's work had been generalised for noncommutative polynomial rings by Bergman and Mora. This thesis provides the corresponding generalisation for Involutive Bases and (to a lesser extent) the Groebner Walk, with the main results being as follows. (1) Algorithms for several new noncommutative involutive divisions are given, including strong; weak; global and local divisions. (2) An algorithm for computing a noncommutative Involutive Basis is given. When used with one of the aforementioned involutive divisions, it is shown that this algorithm returns a noncom...

  7. Mutually unbiased bases

    Indian Academy of Sciences (India)

    S Chaturvedi

    2002-08-01

    After a brief review of the notion of a full set of mutually unbiased bases in an -dimensional Hilbert space, we summarize the work of Wootters and Fields (W K Wootters and B C Fields, Ann. Phys. 191, 363 (1989)) which gives an explicit construction for such bases for the case = r, where is a prime. Further, we show how, by exploiting certain freedom in the Wootters–Fields construction, the task of explicitly writing down such bases can be simplified for the case when is an odd prime. In particular, we express the results entirely in terms of the character vectors of the cyclic group of order . We also analyse the connection between mutually unbiased bases and the representations of .

  8. Kelomehele preemia Baseli festivalil

    Index Scriptorium Estoniae

    2000-01-01

    Baselis festivalil "VIPER - International Festival for Film Video and New Media" tunnistati parimaks CD-ROMiks Gustav Deutschi/Anna Schimeki "Odysee today", netiprojektiks itaallaste "01.ORG", äramärkimispreemia - Raivo Kelomehe "Videoweaver"

  9. WormBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — WormBase is an international consortium of biologists and computer scientists dedicated to providing the research community with accurate, current, accessible...

  10. Language-Based Learning Disabilities

    Science.gov (United States)

    ... Public / Speech, Language and Swallowing / Disorders and Diseases Language-Based Learning Disabilities (Reading, Spelling, and Writing) What ... a language-based learning disability ? What is a language-based learning disability? Language-based learning disabilities are ...

  11. Participatory design based research

    DEFF Research Database (Denmark)

    Dau, Susanne; Falk, Lars; Jensen, Louise Bach

    2014-01-01

    This poster reveal how participatory design based research by the use of a CoED inspired creative process can be used for designing solutions to problems regarding students study activities outside campus.......This poster reveal how participatory design based research by the use of a CoED inspired creative process can be used for designing solutions to problems regarding students study activities outside campus....

  12. DSP Based Waveform Generator

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The DSP Based Waveform Generator is used for CSR Control system to control special controlled objects, such as the pulsed power supply for magnets, RF system, injection and extraction synchronization, global CSR synchronization etc. This intelligent controller based on 4800 MIPS DSP and 256M SDRAM technology will supply highly stable and highly accurate reference waveform used by the power supply of magnets. The specifications are as follows:

  13. Optimisation-based clearance

    OpenAIRE

    Varga, Andras

    2002-01-01

    The basic feature of the optimisation-based clearance approach is to reformulate the clearance problems as equivalent minimum distance problems for which ”anti”-optimisation is performed to determine the worst-case parameter combination/ flight condition leading to worst performance. The basic requirements for the applicability of the optimisation-based approach are the availability of suitable parametric models describing the overall nonlinear dynamics of the augmented aircraft and of accomp...

  14. Computer-based simulations

    OpenAIRE

    Antonoaie, C.; Antonoaie, N.

    2010-01-01

    A computer-based simulation replicates an environment through a computer program designed to consider multiple variables, interactions, and system constraints. Computer-based simulation is used in organization studies to model human social systems to better understand the dynamics between individual and group behaviours.These methods advance organization studies research in many ways. They can be used for extrapolating theory, validating hypotheses, or revealing emergent behaviour. Simulation...

  15. Evidence-Based Development

    DEFF Research Database (Denmark)

    Hertzum, Morten; Simonsen, Jesper

    2004-01-01

    Systems development is replete with projects that represent substantial resource investments but result in systems that fail to meet users’ needs. Evidence-based development is an emerging idea intended to provide means for managing customer-vendor relationships and working systematically toward...... and electronic patient records for diabetes patients, this paper reports research in progress regarding the prospects and pitfalls of evidence-based development....

  16. Layered nickel based superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Ronning, Filip [Los Alamos National Laboratory; Bauer, Eric D [Los Alamos National Laboratory; Park, Tuson [Los Alamos National Laboratory; Kurita, Nobuyuki [Los Alamos National Laboratory; Klimczuk, T [Los Alamos National Laboratory; Movshovich, R [Los Alamos National Laboratory; Thompson, J D [Los Alamos National Laboratory; Sefat, A S [ORNL; Mandrus, D [ORNL

    2009-01-01

    We review the properties of Ni-based superconductors which contain Ni{sub 2}X{sub 2} (X=As, P, Bi, Si, Ge, B) planes, a common structural element to the recently discovered FeAs superconductors. We also compare the properties ofthe Ni-and Fe-based systems from a perspective ofelectronic structure as well as structure-property relations.

  17. Team Based Learning

    OpenAIRE

    ALTINTAŞ, Levent; ALİMOĞLU, Mustafa Kemal

    2012-01-01

    Team-based learning is a learner-centered instructional strategy led by an expert instructor and applied in large learner groups composed of teams including 5-7 individuals in each. The method requires some out-of-class and in-class activities and special team assignments for students to learn at individual and team level. In pure team-based learning, there are three phases: preparation, readiness assurance and application-oriented activities. Peer assessment is used to ensure desire...

  18. Compression-based similarity

    OpenAIRE

    Vitányi, Paul

    2011-01-01

    First we consider pair-wise distances for literal objects consisting of finite binary files. These files are taken to contain all of their meaning, like genomes or books. The distances are based on compression of the objects concerned, normalized, and can be viewed as similarity distances. Second, we consider pair-wise distances between names of objects, like "red" or "christianity." In this case the distances are based on searches of the Internet. Such a search can be performed by any search...

  19. Hydrogel based occlusion systems

    OpenAIRE

    Stam, F.A.; Jackson, N.; Dubruel, P.; Adesanya, K.; Embrechts, A.; Mendes, E.; Neves, H.P.; Herijgers, P.; Verbrugghe, Y.; Shacham, Y; Engel, L.; Krylov, V.

    2013-01-01

    A hydrogel based occlusion system, a method for occluding vessels, appendages or aneurysms, and a method for hydrogel synthesis are disclosed. The hydrogel based occlusion system includes a hydrogel having a shrunken and a swollen state and a delivery tool configured to deliver the hydrogel to a target occlusion location. The hydrogel is configured to permanently occlude the target occlusion location in the swollen state. The hydrogel may be an electro-activated hydrogel (EAH) which could be ...

  20. REST based mobile applications

    Science.gov (United States)

    Rambow, Mark; Preuss, Thomas; Berdux, Jörg; Conrad, Marc

    2008-02-01

    Simplicity is the major advantage of REST based webservices. Whereas SOAP is widespread in complex, security sensitive business-to-business aplications, REST is widely used for mashups and end-user centric applicatons. In that context we give an overview of REST and compare it to SOAP. Furthermore we apply the GeoDrawing application as an example for REST based mobile applications and emphasize on pros and cons for the use of REST in mobile application scenarios.

  1. LDEF materials data bases

    Science.gov (United States)

    Funk, Joan G.; Strickland, John W.; Davis, John M.

    1993-01-01

    The Long Duration Exposure Facility (LDEF) and the accompanying experiments were composed of and contained a wide variety of materials representing the largest collection of materials flown in low Earth orbit (LEO) and retrieved for ground based analysis to date. The results and implications of the mechanical, thermal, optical, and electrical data from these materials are the foundation on which future LEO space missions will be built. The LDEF Materials Special Investigation Group (MSIG) has been charged with establishing and developing data bases to document these materials and their performance to assure not only that the data are archived for future generations but also that the data are available to the spacecraft user community in an easily accessed, user-friendly form. This paper discusses the format and content of the three data bases developed or being developed to accomplish this task. The hardware and software requirements for each of these three data bases are discussed along with current availability of the data bases. This paper also serves as a user's guide to the MAPTIS LDEF Materials Data Base.

  2. Noncommutative Involutive Bases

    Science.gov (United States)

    Alun Evans, Gareth

    2006-02-01

    The theory of Groebner Bases originated in the work of Buchberger and is now considered to be one of the most important and useful areas of symbolic computation. A great deal of effort has been put into improving Buchberger's algorithm for computing a Groebner Basis, and indeed in finding alternative methods of computing Groebner Bases. Two of these methods include the Groebner Walk method and the computation of Involutive Bases. By the mid 1980's, Buchberger's work had been generalised for noncommutative polynomial rings by Bergman and Mora. This thesis provides the corresponding generalisation for Involutive Bases and (to a lesser extent) the Groebner Walk, with the main results being as follows. (1) Algorithms for several new noncommutative involutive divisions are given, including strong; weak; global and local divisions. (2) An algorithm for computing a noncommutative Involutive Basis is given. When used with one of the aforementioned involutive divisions, it is shown that this algorithm returns a noncommutative Groebner Basis on termination. (3) An algorithm for a noncommutative Groebner Walk is given, in the case of conversion between two harmonious monomial orderings. It is shown that this algorithm generalises to give an algorithm for performing a noncommutative Involutive Walk, again in the case of conversion between two harmonious monomial orderings. (4) Two new properties of commutative involutive divisions are introduced (stability and extendibility), respectively ensuring the termination of the Involutive Basis algorithm and the applicability (under certain conditions) of homogeneous methods of computing Involutive Bases.

  3. Nitramine Double Base Propellants

    Directory of Open Access Journals (Sweden)

    M. M. Bhalerao

    1996-10-01

    Full Text Available This review paper broadly covers the studies conducted on nitramine double base (DB propellants, particularly in the field of formulations, evaluation, catalysis and combustion mechanism . Addition of RDX and HMX in double base matrix shows relatively low burn rates and high paper index values. Further, the burn rate of this class of propellants enhances in the presence of energetic binders/plasticisers like glycidyl azide polymer. This paper also discusses the combustion mechanism of HMX/RDX-based DB propellants, especially in the presence of catalytic salts. As scanty data is available on extruded nitramine DB propellants, further work is needed in the field of formulation as well as evaluation with a view to generate exhaustive data.

  4. SAR based adaptive GMTI

    Science.gov (United States)

    Vu, Duc; Guo, Bin; Xu, Luzhou; Li, Jian

    2010-04-01

    We consider ground moving target indication (GMTI) and target velocity estimation based on multi-channel synthetic aperture radar (SAR) images. Via forming velocity versus cross-range images, we show that small moving targets can be detected even in the presence of strong stationary ground clutter. Moreover, the velocities of the moving targets can be estimated, and the misplaced moving targets can be placed back to their original locations based on the estimated velocities. Adaptive beamforming techniques, including Capon and generalizedlikelihood ratio test (GLRT), are used to form velocity versus cross-range images for each range bin of interest. The velocity estimation ambiguities caused by the multi-channel array geometry are analyzed. We also demonstrate the effectiveness of our approaches using the Air Force Research Laboratory (AFRL) publicly-released Gotcha SAR based GMTI data set.

  5. Cantilever Based Mass Sensing

    DEFF Research Database (Denmark)

    Dohn, Søren

    2007-01-01

    Cantilever based mass sensors utilize that a change in vibrating mass will cause a change in the resonant frequency. This can be used for very accurate sensing of adsorption and desorption processes on the cantilever surface. The change in resonant frequency caused by a single molecule depends...... on various parameters including the vibrating mass of the cantilever and the frequency at which it vibrates. The minimum amount of molecules detectable is highly dependent on the noise of the system as well as the method of readout. The aim of this Ph.D. thesis has been twofold: To develop a readout method...... suitable for a portable device and to investigate the possibility of enhancing the functionality and sensitivity of cantilever based mass sensors. A readout method based on the hard contact between the cantilever and a biased electrode placed in close proximity to the cantilever is proposed. The viability...

  6. Location-based Scheduling

    DEFF Research Database (Denmark)

    Andersson, Niclas; Christensen, Knud

    the predominant scheduling method since it was introduced in the late 1950s. Over the years, CPM has proven to be a very powerful technique for planning, scheduling and controlling projects, which among other things is indicated by the development of a large number of CPM-based software applications available...... on the market. However, CPM is primarily an activity based method that takes the activity as the unit of focus and there is criticism raised, specifically in the case of construction projects, on the method for deficient management of construction work and continuous flow of resources. To seek solutions...... to the identified limitations of the CPM method, an alternative planning and scheduling methodology that includes locations is tested. Location-based Scheduling (LBS) implies a shift in focus, from primarily the activities to the flow of work through the various locations of the project, i.e. the building. LBS uses...

  7. Inkjet-based micromanufacturing

    CERN Document Server

    Korvink, Jan G; Shin, Dong-Youn; Brand, Oliver; Fedder, Gary K; Hierold, Christofer; Tabata, Osamu

    2012-01-01

    Inkjet-based Micromanufacturing Inkjet technology goes way beyond putting ink on paper: it enables simpler, faster and more reliable manufacturing processes in the fields of micro- and nanotechnology. Modern inkjet heads are per se precision instruments that deposit droplets of fluids on a variety of surfaces in programmable, repeating patterns, allowing, after suitable modifications and adaptations, the manufacturing of devices such as thin-film transistors, polymer-based displays and photovoltaic elements. Moreover, inkjet technology facilitates the large-scale production of flexible RFID tr

  8. Identity-based encryption

    CERN Document Server

    Chatterjee, Sanjit

    2011-01-01

    Identity Based Encryption (IBE) is a type of public key encryption and has been intensely researched in the past decade. Identity-Based Encryption summarizes the available research for IBE and the main ideas that would enable users to pursue further work in this area. This book will also cover a brief background on Elliptic Curves and Pairings, security against chosen Cipher text Attacks, standards and more. Advanced-level students in computer science and mathematics who specialize in cryptology, and the general community of researchers in the area of cryptology and data security will find Ide

  9. Video-based rendering

    CERN Document Server

    Magnor, Marcus A

    2005-01-01

    Driven by consumer-market applications that enjoy steadily increasing economic importance, graphics hardware and rendering algorithms are a central focus of computer graphics research. Video-based rendering is an approach that aims to overcome the current bottleneck in the time-consuming modeling process and has applications in areas such as computer games, special effects, and interactive TV. This book offers an in-depth introduction to video-based rendering, a rapidly developing new interdisciplinary topic employing techniques from computer graphics, computer vision, and telecommunication en

  10. Domain based metering

    OpenAIRE

    Párhonyi, Robert; Beijnum, van, Bert-Jan

    2000-01-01

    In the last two years, there is a gaining interest in usage based accounting for the Internet. One of the driving forces for this growing interest is the progress being made in providing some form of quality assurance in IP packet forwarding. One of the key processes in an accounting system is metering, gathering of network usage parameters on which the accounting is or can be based. In this paper are addressed issues that are potentially of interest in Internet accounting. One of these issue...

  11. Iron-based superconductivity

    CERN Document Server

    Johnson, Peter D; Yin, Wei-Guo

    2015-01-01

    This volume presents an in-depth review of experimental and theoretical studies on the newly discovered Fe-based superconductors.  Following the Introduction, which places iron-based superconductors in the context of other unconventional superconductors, the book is divided into three sections covering sample growth, experimental characterization, and theoretical understanding.  To understand the complex structure-property relationships of these materials, results from a wide range of experimental techniques and theoretical approaches are described that probe the electronic and magnetic prope

  12. Plasmonics based VLSI processes

    Directory of Open Access Journals (Sweden)

    Shreya Bhattacharya

    2013-03-01

    Full Text Available In continuum to my previous paper titled ‘Implementation of plasmonics in VLSI’, this paper attempts to explore further, the actual physical realization of an all-plasmonic chip. In this paper, various methods of plasmon-based photolithography have been discussed and an observation is made w.r.t the cost effectiveness and ease of adaptability. Also, plasmonics based active element has been discussed which would help unravel further arenas of approaches and methods towards the realization of an all-plasmonic chip.

  13. Pitch Based Sound Classification

    DEFF Research Database (Denmark)

    Nielsen, Andreas Brinch; Hansen, Lars Kai; Kjems, U

    2006-01-01

    A sound classification model is presented that can classify signals into music, noise and speech. The model extracts the pitch of the signal using the harmonic product spectrum. Based on the pitch estimate and a pitch error measure, features are created and used in a probabilistic model with soft...

  14. Skull Base Tumors

    Science.gov (United States)

    Schulz-Ertner, Daniela

    In skull base tumors associated with a low radiosensitivity for conventional radiotherapy (RT), irradiation with proton or carbon ion beams facilitates a safe and accurate application of high tumor doses due to the favorable beam localization properties of these particle beams. Cranial nerves, the brain stem and normal brain tissue can at the same time be optimally spared.

  15. Base tree property

    Czech Academy of Sciences Publication Activity Database

    Balcar, B.; Doucha, Michal; Hrušák, M.

    2015-01-01

    Roč. 32, č. 1 (2015), s. 69-81. ISSN 0167-8094 R&D Projects: GA AV ČR IAA100190902 Institutional support: RVO:67985840 Keywords : forcing * Boolean algebra s * base tree Subject RIV: BA - General Mathematics Impact factor: 0.621, year: 2014 http://link.springer.com/article/10.1007/s11083-013-9316-2

  16. Surfel Based Geometry Resonstruction

    DEFF Research Database (Denmark)

    Andersen, Vedrana; Aanæs, Henrik; Bærentzen, Jakob Andreas

    We propose a method for retrieving a piecewise smooth surface from noisy data. In data acquired by a scanning process sampled points are almost never on the discontinuities making reconstruction of surfaces with sharp features difficult. Our method is based on a Markov Random Field (MRF) formulat...

  17. 80537 based distance relay

    DEFF Research Database (Denmark)

    Pedersen, Knud Ole Helgesen

    1999-01-01

    A method for implementing a digital distance relay in the power system is described.Instructions are given on how to program this relay on a 80537 based microcomputer system.The problem is used as a practical case study in the course 53113: Micocomputer applications in the power system.The relay is...

  18. Protein Crystal Based Nanomaterials

    Science.gov (United States)

    Bell, Jeffrey A.; VanRoey, Patrick

    2001-01-01

    This is the final report on a NASA Grant. It concerns a description of work done, which includes: (1) Protein crystals cross-linked to form fibers; (2) Engineering of protein to favor crystallization; (3) Better knowledge-based potentials for protein-protein contacts; (4) Simulation of protein crystallization.

  19. Internet based benchmarking

    DEFF Research Database (Denmark)

    Bogetoft, Peter; Nielsen, Kurt

    2005-01-01

    We discuss the design of interactive, internet based benchmarking using parametric (statistical) as well as nonparametric (DEA) models. The user receives benchmarks and improvement potentials. The user is also given the possibility to search different efficiency frontiers and hereby to explore...

  20. Zero Base Budgeting.

    Science.gov (United States)

    Sarndal, Anne G.

    1979-01-01

    Traditional budgeting starts with the previous year's budget, but zero base budgeting demands that each activity be justified from "scratch," and establishes a number of increments for each unit, in order of priority. Given the set of increments and the money available, management can determine what activities to finance. (Author)

  1. Diffusion Based Photon Mapping

    DEFF Research Database (Denmark)

    Schjøth, Lars; Sporring, Jon; Fogh Olsen, Ole

    2008-01-01

    . To address this problem, we introduce a photon mapping algorithm based on nonlinear anisotropic diffusion. Our algorithm adapts according to the structure of the photon map such that smoothing occurs along edges and structures and not across. In this way, we preserve important illumination features...

  2. BASE - Progress Report 2015

    CERN Document Server

    Ulmer, S; Mooser, A; Sellner, S; Nagahama, H; Higuchi, T; Borchert, M; Schneider, G; Tanaka, T; Blaum, K; Matsuda, Y; Ospelkaus, C; Quint, W; Walz, J; Yamazaki, Y; CERN. Geneva. SPS and PS Experiments Committee; SPSC

    2016-01-01

    The BASE collaboration aims at high-precision comparisons of the fundamental properties of the proton and the antiproton, namely, the magnetic g-factors as well as the charge-to-mass ratios of the particles. This annual report summarizes the achievements made in CERN's 2015 antiproton run.

  3. Animation-based Sketching

    DEFF Research Database (Denmark)

    Vistisen, Peter

    experiments has been carried out, applying animation-based sketching in various contexts and at varying points in the design process. In the studies, I evaluate the viability of the approach, the practical integration into the design process, and map how consensus between stakeholders in design can be...

  4. XML Based UIScript

    Institute of Scientific and Technical Information of China (English)

    CAI Bin; LIAO Jian-xin; SHEN Qi-wei

    2004-01-01

    In this paper, after the analyzing the UIScript mechanism in intelligent peripheral, a new approach of XML-based UIScript is put forward. The related issues such as the design of UIScript language, the execution environment and its relationship with other script languages are discussed.

  5. Evidence-based policy

    DEFF Research Database (Denmark)

    Vohnsen, Nina Holm

    2013-01-01

    research community (e.g. Boden & Epstein 2006; House of Commons 2006; Cartwright et al 2009; Rod 2010; Vohnsen 2011). This article intends to draw out some general pitfalls in the curious meeting of science and politics by focusing on a particular attempt to make evidence-based legislation in Denmark (for...

  6. Centroid Based Text Clustering

    Directory of Open Access Journals (Sweden)

    Priti Maheshwari

    2010-09-01

    Full Text Available Web mining is a burgeoning new field that attempts to glean meaningful information from natural language text. Web mining refers generally to the process of extracting interesting information and knowledge from unstructured text. Text clustering is one of the important Web mining functionalities. Text clustering is the task in which texts are classified into groups of similar objects based on their contents. Current research in the area of Web mining is tacklesproblems of text data representation, classification, clustering, information extraction or the search for and modeling of hidden patterns. In this paper we propose for mining large document collections it is necessary to pre-process the web documents and store the information in a data structure, which is more appropriate for further processing than a plain web file. In this paper we developed a php-mySql based utility to convert unstructured web documents into structured tabular representation by preprocessing, indexing .We apply centroid based web clustering method on preprocessed data. We apply three methods for clustering. Finally we proposed a method that can increase accuracy based on clustering ofdocuments.

  7. Inservice testing bases program

    International Nuclear Information System (INIS)

    Inservice testing (IST) programs generally address those components necessary for safe operation as specified in Subsections IWP-1100 and IWV-1100 of Section 11 (American Society of Mechanical Engineers Boiler and Pressure Vessel Code) and Position 11 of the US Nuclear Regulatory Commission Generic Letter 89-04. Program tables, generated manually or from computer databases, are frequently used to describe those components and testing requirements contained in IST programs. Table entries are usually derived from review of system drawings, accident analysis, and other technical documents; however, the bases for such entries are not always documented. Because IST programs are dynamic, the continual evaluation of program entries may be inhibited if bases for program entries are unclear. When IST programs have been developed by architect-engineers, nuclear steam supply system suppliers, or other contractors, the bases for IST program contents become even more nebulous to the program users. The presentation provides a discussion of IST bases programs used by Entergy Operations' four nuclear plants, and the benefits derived from their use

  8. Dictionary Based Image Segmentation

    DEFF Research Database (Denmark)

    Dahl, Anders Bjorholm; Dahl, Vedrana Andersen

    2015-01-01

    We propose a method for weakly supervised segmentation of natural images, which may contain both textured or non-textured regions. Our texture representation is based on a dictionary of image patches. To divide an image into separated regions with similar texture we use an implicit level sets...

  9. Problem-Based Learning

    Science.gov (United States)

    Allen, Deborah E.; Donham, Richard S.; Bernhardt, Stephen A.

    2011-01-01

    In problem-based learning (PBL), students working in collaborative groups learn by resolving complex, realistic problems under the guidance of faculty. There is some evidence of PBL effectiveness in medical school settings where it began, and there are numerous accounts of PBL implementation in various undergraduate contexts, replete with…

  10. Performance based fault diagnosis

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik

    2002-01-01

    Different aspects of fault detection and fault isolation in closed-loop systems are considered. It is shown that using the standard setup known from feedback control, it is possible to formulate fault diagnosis problems based on a performance index in this general standard setup. It is also shown...

  11. Aptamer-based nanobiosensors.

    Science.gov (United States)

    Kim, Yeon Seok; Raston, Nurul Hanun Ahmad; Gu, Man Bock

    2016-02-15

    It has been more than two decades since aptamer and the systematic evolution of ligands by exponential enrichment (SELEX) method were discovered by Larry Gold and Andrew Ellington in 1990, respectively. Based on the various advantages of aptamers, they have become a potent rival of antibodies in therapeutics and bio-analysis. Especially, the recent advances in aptamer biosensor application are remarkable due to its intrinsic properties of aptamers as nucleic acids and target induced conformational changes, in addition to the introduction of graphene oxide-based easy and simple immobilization-free screening method even for dual aptamers. In addition, the incorporation of various nanomaterials such as metallic nanoparticles, carbon materials, and functional nanospheres in aptasensors has facilitated the improvement of analytical performance and commercial application of aptasensors. In this review, recent prominent reports on aptasensors utilizing nanomaterials were introduced to understand the principle of aptamer-based biosensors and provide an insight for new strategies of aptasensors and the application of various nanomaterials. The perspective on aptamer-based biosensors and diagnostics was also discussed in view of technology and market. PMID:26139320

  12. Lunar Base Sitting

    Science.gov (United States)

    Staehle, Robert L.; Burke, James D.; Snyder, Gerald C.; Dowling, Richard; Spudis, Paul D.

    1993-12-01

    Speculation with regard to a permanent lunar base has been with us since Robert Goddard was working on the first liquid-fueled rockets in the 1920's. With the infusion of data from the Apollo Moon flights, a once speculative area of space exploration has become an exciting possibility. A Moon base is not only a very real possibility, but is probably a critical element in the continuation of our piloted space program. This article, originally drafted by World Space Foundation volunteers in conjuction with various academic and research groups, examines some of the strategies involved in selecting an appropriate site for such a lunar base. Site selection involves a number of complex variables, including raw materials for possible rocket propellant generation, hot an cold cycles, view of the sky (for astronomical considerations, among others), geological makeup of the region, and more. This article summarizes the key base siting considerations and suggests some alternatives. Availability of specific resources, including energy and certain minerals, is critical to success.

  13. PROJECT-BASES RISK MANAGEMENT

    OpenAIRE

    Andrei Sandu

    2010-01-01

    The project-bases concept is presented. There are defined operations on project-bases. The software developed for project-bases management is analyzed based in its structure and functionality. A series of criteria of structuring risks is listed are tailored for project-bases management. Next there are suggested solutions of mitigating risks by maintaining efficiency within acceptable thresholds.

  14. Advances in the chemistry of monocyclic amino- and nitrofuroxans

    International Nuclear Information System (INIS)

    The review summarizes data on the development of methods of synthesis and reactivity of monocyclic amino- and nitrofuroxans published in the last 20–25 years. The details of the synthesis of aminofuroxans based on the Schmidt and Curtius rearrangements involving acetyl- and azidocarbonylfuroxans, respectively, are discussed. Specific features of the transformations of functional substituents in aminofuroxans are described. In consideration of the reactivity of aminofuroxans, the attention is focused on the oxidation, diazotization and the Mannich reaction. Methods of synthesis of nitrofuroxans based on the oxidation of nitroglyoximes and the nitrosation of unsaturated compounds and dipotassium salts of 2-substituted 2-hydroxyimino-1,1-dinitroethanes are covered. The reactivity of nitrofuroxans comprises the nucleophilic substitution, reduction and thermal furoxan ring opening to form nitrile oxides. The bibliography includes 111 references

  15. Quasigroup based crypto-algorithms

    OpenAIRE

    Shcherbacov, Victor

    2012-01-01

    Modifications of Markovski quasigroup based crypto-algorithm have been proposed. Some of these modifications are based on the systems of orthogonal n-ary groupoids. T-quasigroups based stream ciphers have been constructed.

  16. Spintronics-based computing

    CERN Document Server

    Prenat, Guillaume

    2015-01-01

    This book provides a comprehensive introduction to spintronics-based computing for the next generation of ultra-low power/highly reliable logic, which is widely considered a promising candidate to replace conventional, pure CMOS-based logic. It will cover aspects from device to system-level, including magnetic memory cells, device modeling, hybrid circuit structure, design methodology, CAD tools, and technological integration methods. This book is accessible to a variety of readers and little or no background in magnetism and spin electronics are required to understand its content.  The multidisciplinary team of expert authors from circuits, devices, computer architecture, CAD and system design reveal to readers the potential of spintronics nanodevices to reduce power consumption, improve reliability and enable new functionality.  .

  17. Graphene-based electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Xiao; Zeng, Zhiyuan; Fan, Zhanxi; Liu, Juqing; Zhang, Hua [School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798 (Singapore)

    2012-11-27

    Graphene, the thinnest two dimensional carbon material, has become the subject of intensive investigation in various research fields because of its remarkable electronic, mechanical, optical and thermal properties. Graphene-based electrodes, fabricated from mechanically cleaved graphene, chemical vapor deposition (CVD) grown graphene, or massively produced graphene derivatives from bulk graphite, have been applied in a broad range of applications, such as in light emitting diodes, touch screens, field-effect transistors, solar cells, supercapacitors, batteries, and sensors. In this Review, after a short introduction to the properties and synthetic methods of graphene and its derivatives, we will discuss the importance of graphene-based electrodes, their fabrication techniques, and application areas. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  18. Graphene-based electrodes.

    Science.gov (United States)

    Huang, Xiao; Zeng, Zhiyuan; Fan, Zhanxi; Liu, Juqing; Zhang, Hua

    2012-11-27

    Graphene, the thinnest two dimensional carbon material, has become the subject of intensive investigation in various research fields because of its remarkable electronic, mechanical, optical and thermal properties. Graphene-based electrodes, fabricated from mechanically cleaved graphene, chemical vapor deposition (CVD) grown graphene, or massively produced graphene derivatives from bulk graphite, have been applied in a broad range of applications, such as in light emitting diodes, touch screens, field-effect transistors, solar cells, supercapacitors, batteries, and sensors. In this Review, after a short introduction to the properties and synthetic methods of graphene and its derivatives, we will discuss the importance of graphene-based electrodes, their fabrication techniques, and application areas. PMID:22927209

  19. Sparse approximation with bases

    CERN Document Server

    2015-01-01

    This book systematically presents recent fundamental results on greedy approximation with respect to bases. Motivated by numerous applications, the last decade has seen great successes in studying nonlinear sparse approximation. Recent findings have established that greedy-type algorithms are suitable methods of nonlinear approximation in both sparse approximation with respect to bases and sparse approximation with respect to redundant systems. These insights, combined with some previous fundamental results, form the basis for constructing the theory of greedy approximation. Taking into account the theoretical and practical demand for this kind of theory, the book systematically elaborates a theoretical framework for greedy approximation and its applications.  The book addresses the needs of researchers working in numerical mathematics, harmonic analysis, and functional analysis. It quickly takes the reader from classical results to the latest frontier, but is written at the level of a graduate course and do...

  20. Knowledge based maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Sturm, A. [Hamburgische Electacitaets-Werke AG Hamburg (Germany)

    1997-12-31

    The establishment of maintenance strategies is of crucial significance for the reliability of a plant and the economic efficiency of maintenance measures. Knowledge about the condition of components and plants from the technical and business management point of view therefore becomes one of the fundamental questions and the key to efficient management and maintenance. A new way to determine the maintenance strategy can be called: Knowledge Based Maintenance. A simple method for determining strategies while taking the technical condition of the components of the production process into account to the greatest possible degree which can be shown. A software with an algorithm for Knowledge Based Maintenance leads the user during complex work to the determination of maintenance strategies for this complex plant components. (orig.)

  1. Content Based Video Retrieval

    Directory of Open Access Journals (Sweden)

    B.V.Patel

    2012-11-01

    Full Text Available Content based video retrieval is an approach for facilitating the searching and browsing of large image collections over World Wide Web. In this approach, video analysis is conducted on low level visual properties extracted from video frame. We believed that in order to create an effective video retrieval system, visual perception must be taken into account. We conjectured that a technique which employs multiple features for indexing and retrieval would be more effective in the discrimination and search tasks of videos. In order to validate this claim, content based indexing and retrieval systems were implemented using color histogram, various texture features and other approaches. Videos were stored in Oracle 9i Database and a user study measured correctness of response.

  2. Content Based Video Retrieval

    Directory of Open Access Journals (Sweden)

    B. V. Patel

    2012-10-01

    Full Text Available Content based video retrieval is an approach for facilitating the searching and browsing of large image collections over World Wide Web. In this approach, video analysis is conducted on low level visual properties extracted from video frame. We believed that in order to create an effective video retrieval system, visual perception must be taken into account. We conjectured that a technique which employs multiple features for indexing and retrieval would be more effective in the discrimination and search tasks of videos. In order to validate this claim, content based indexing and retrieval systems were implemented using color histogram, various texture features and other approaches. Videos were stored in Oracle 9i Database and a user study measured correctness of response.

  3. Trajectory Based Traffic Analysis

    DEFF Research Database (Denmark)

    Krogh, Benjamin Bjerre; Andersen, Ove; Lewis-Kelham, Edwin;

    2013-01-01

    We present the INTRA system for interactive path-based traffic analysis. The analyses are developed in collaboration with traffic researchers and provide novel insights into conditions such as congestion, travel-time, choice of route, and traffic-flow. INTRA supports interactive point-and-click a......We present the INTRA system for interactive path-based traffic analysis. The analyses are developed in collaboration with traffic researchers and provide novel insights into conditions such as congestion, travel-time, choice of route, and traffic-flow. INTRA supports interactive point......-and-click analysis, due to a novel and efficient indexing structure. With the web-site daisy.aau.dk/its/spqdemo/we will demonstrate several analyses, using a very large real-world data set consisting of 1.9 billion GPS records (1.5 million trajectories) recorded from more than 13000 vehicles, and touching most of...

  4. Maintaining Relationship Based Procurement

    Directory of Open Access Journals (Sweden)

    Peter Davis

    2012-11-01

    Full Text Available Alliance and relationship projects are increasingin number and represent a large pool of work. Tobe successful relationship style contracts dependon soft-dollar factors, particularly the participants'ability to work together within an agreedframework, generally they are not based on lowbid tendering. Participants should be prepared todo business in an open environment based ontrust and mutually agreed governance. Theresearch evaluates relationship maintenance inthe implementation phase of constructionalliances - a particular derivative of relationshipstyle contracts. To determine the factors thatcontribute to relationship maintenance forty-nineexperienced Australian alliance projectmanagers were interviewed. The main findingswere; the development of relationships early inthe project form building blocks of success fromwhich relationships are maintained and projectvalue added; quality facilitation plays animportant part in relationship maintenance and ahybrid organisation created as a result of alliancedevelopment overcomes destructiveorganisational boundaries. Relationshipmaintenance is integral to alliance project controland failure to formalise it and pay attention toprocess and past outcomes will undermine analliance project's potential for success.

  5. Radiation-based security

    International Nuclear Information System (INIS)

    The problems presented in different security areas are varied but the solutions that have been offered are generally based upon the same principles. Employing radiation to locate and identify explosives or contraband has been most obvious at airports but other locations are now receiving equal attention. Neutron and X-ray interrogation are the systems most frequently employed. However, the more recently developed approaches such as multi-view dual-energy imaging and the use of high-speed diffraction measurements are the most likely systems to become widely available. This review looks briefly at the neutron and X-ray based systems that have been developed indicating their mode of operation and their advantages and disadvantages. It then summarizes the current state-of-the-art. The paper finishes by looking in some detail at one of the most promising areas of development--in-line diffraction measurements. (author)

  6. Skull base bone hyperpneumatization

    OpenAIRE

    Houet, E J; Kouokam, L.M.; Nchimi, A L

    2013-01-01

    A 50-year-old male with a long standing history of compulsive Valsalva maneuvers, complaining of episodes of vertigo underwent head computed tomography. Axial CT slices at the level of the skull base (Fig. A) and the first cervical vertebrae (Fig. B) shows an extensive unusual pneumatization of both the body and lateral processes of the first cervical vertebrae (arrows), with air pouches dissecting planes between bone cortex and the periosteum around the occipital bone and the lateral process...

  7. Spiritual-based Leadership

    DEFF Research Database (Denmark)

    Pruzan, Peter

    2015-01-01

    Although far from mainstream, the concept of spiritual-based leadership is emerging as an inclusive and yet highly personal approach to leadership that integrates a leader’s inner perspectives on identity, purpose, responsibility and success with her or his decisions and actions in the outer world...... of business—and therefore it is also emerging as a significant framework for understanding, practicing, communicating and teaching the art and profession of leadership....

  8. Refrigerator Based on Chemisorption

    Science.gov (United States)

    Jones, Jack A.

    1987-01-01

    Reversible chemical reaction generates pressurized oxygen for cooling. Concept for cryogenic refrigerator based on chemical absorption of oxygen by praseodymium/cerium oxide (PCO) compound. Refrigerator produces cryogenic liquid for cooling infrared sensors. Also used for liquefying air and separating oxygen from nitrogen in air. In chemisorption refrigerator, PCO alternately absorbs and desorbs oxygen depending on whether cooled or heated. One pair of compressors accepts oxygen while others releases it. Compressed oxygen liquefied when precooked and expanded.

  9. Model-based segmentation

    OpenAIRE

    Heimann, Tobias; Delingette, Hervé

    2011-01-01

    This chapter starts with a brief introduction into model-based segmentation, explaining the basic concepts and different approaches. Subsequently, two segmentation approaches are presented in more detail: First, the method of deformable simplex meshes is described, explaining the special properties of the simplex mesh and the formulation of the internal forces. Common choices for image forces are presented, and how to evolve the mesh to adapt to certain structures. Second, the method of point...

  10. Onlincolnshire Knowledge Base Collaboration

    OpenAIRE

    Fuller, Ted; Bosworth, Gary; Deville, Jane

    2016-01-01

    This report outlines the Onlincolnshire Knowledge Base Collaboration project undertaken by Lincoln Business School between May 2014 and September 2015. Onlincolnshire is a Lincolnshire County Council-run project which is part-funded by the East Midlands European Regional Development Fund (ERDF) Programme 2007 to 2013. As well as improving the broadband infrastructure, Onlincolnshire delivered a range of support to Lincolnshire’s Small and Medium Sized Enterprises (SMEs) through the “Business...

  11. Ferrocene base metal chelates

    International Nuclear Information System (INIS)

    Review of the works, devoted to different types of ferrocene metal chelates and to a possibility of ferrocene-containing ligand modification by means of complexing, is presented. Structure, properties and spectral characteristics of transitional metal, rare earth element, Cd2+, UO22+, Th4+ etc. complexes with ferrocene diketones, ferrocene acyl derivatives based on thiosemicarbazones and hydrazones and other heterometal ferrocene-containing metal chelates, are considered. 134 refs., 1 tab

  12. Polysiloxane based neutron detectors

    OpenAIRE

    Dalla Palma, Matteo

    2016-01-01

    In the last decade, neutron detection has been attracting the attention of the scientific community for different reasons. On one side, the increase in the price of 3He, employed in the most efficient and the most widely used neutron detectors. On the other side, the harmfulness of traditional xylene based liquid scintillators, used in extremely large volumes for the detection of fast neutrons. Finally, the demand for most compact and rough systems pushed by the increased popularity of neutro...

  13. Argument based machine learning

    OpenAIRE

    Možina, Martin

    2014-01-01

    The Thesis presents a novel approach to machine learning, called ABML (argument based machine learning). This approach combines machine learning from examples with some concepts from the field of defeasible argumentation, where arguments are used together with learning examples by learning methods in the induction of a hypothesis. An argument represents a relation between the class value of a particular learning example and its attributes and can be regarded as a partial explanation of this e...

  14. OCR Based Pixel Fusion

    OpenAIRE

    Rami Al-Hmouz

    2012-01-01

    Character recognition is the process that allows the automatic identification of character images, which is generally referred as Optical Character Recognition (OCR). The characters are either handwritten or typed. This study proposed a novel OCR approach based on the likelihood functions of pixels, which were obtained by averaging a trained set of character images. A Bayesian fusion process for all pixel probabilities decides the recognition of characters. Further tests using Support V...

  15. Lignocellulose-based bioproducts

    CERN Document Server

    Karimi, Keikhosro

    2015-01-01

    This volume provides the technical information required for the production of biofuels and chemicals from lignocellulosic biomass. It starts with a brief overview of the importance, applications, and production processes of different lignocellulosic products. Further chapters review the perspectives of waste-based biofuels and biochemicals; the pretreatment of lignocellulosic biomass for biofuel production; cellulolytic enzyme systems for the hydrolysis of lignocelluloses; and basic and applied aspects of the production of bioethanol, biogas, biohydrogen, and biobutanol from lignocelluloses.

  16. REST based service composition

    DEFF Research Database (Denmark)

    Grönvall, Erik; Ingstrup, Mads; Pløger, Morten;

    2011-01-01

    This paper presents an ongoing work developing and testing a Service Composition framework based upon the REST architecture named SECREST. A minimalistic approach have been favored instead of a creating a complete infrastructure. One focus has been on the system's interaction model. Indeed, an aim...... is to allow users in different healthcare scenarios to experiment with service composition to support highly individual and changing needs....

  17. Evidence based pediatrics.

    OpenAIRE

    Elizabeta ZISOVSKA

    2015-01-01

    It is very difficult to define the entire phrase “Evidence based pediatrics”, covering all components of this overused sentence. The definition comes out of the common sentence and it means integration of the individual clinical expertize together with the best external clinically available evidence of the systematic reviews which are of interest and benefit of the individual patient.Development of clinically appropriate structured question follows PICO model, i.e. containing f...

  18. Design bases - Concrete structures

    International Nuclear Information System (INIS)

    The most suitable title for Section 2 is 'Design Bases', which covers not only calculation but also the following areas: - Structural design concepts. - Project criteria. - Material specifications. These concepts are developed in more detail in the following sections. The numbering in this document is neither complete nor hierarchical since, for easier cross referencing, it corresponds to the paragraphs of Eurocode 2 Part 1 (hereinafter 'EUR-2') which are commented on. (author)

  19. MEMS based reference oscillator

    OpenAIRE

    Hedestig, Joel

    2005-01-01

    The interest in tiny wireless applications raises the demand for an integrated reference oscillator with the same performance as the macroscopic quartz crystal reference oscillators. The main challenge of the thesis is to prove that it is possible to build a MEMS based oscillator that approaches the accuracy level of existing quartz crystal oscillators. The MEMS resonator samples which Philips provides are measured and an equivalent electrical model is designed for them. This model is used in...

  20. Dictionary Based Image Segmentation

    OpenAIRE

    Dahl, Anders Bjorholm; Dahl, Vedrana Andersen

    2015-01-01

    We propose a method for weakly supervised segmentationof natural images, which may contain both textured or non-texturedregions. Our texture representation is based on a dictionary of imagepatches. To divide an image into separated regions with similar texturewe use an implicit level sets representation of the curve, which makesour method topologically adaptive. In addition, we suggest a multi-labelversion of the method. Finally, we improve upon a similar texture representation,by formulating...

  1. Knowledge Based Economy Assessment

    OpenAIRE

    Madalina Cristina Tocan

    2012-01-01

    The importance of knowledge-based economy (KBE) in the XXI century is evident. In the article the reflection of knowledge on economy is analyzed. The main point is targeted to the analysis of characteristics of knowledge expression in economy and to the construction of structure of KBE expression. This allows understanding the mechanism of functioning of knowledge economy. The authors highlight the possibility to assess the penetration level of KBE which could manifest itself trough the exist...

  2. Instance based function learning

    OpenAIRE

    Ramon, Jan; De Raedt, Luc

    1999-01-01

    The principles of instance based function learning are presented. In IBFL one is given a set of positive examples of a functional predicate. These examples are true ground facts that illustrate the input output behaviour of the predicate. The purpose is then to predict the output of the predicate given a new input. Further assumptions are that there is no background theory and that the inputs and outputs of the predicate consist of structured terms. IBFL is a novel technique that addresses th...

  3. Plasmonics based VLSI processes

    Directory of Open Access Journals (Sweden)

    Shreya Bhattacharya

    2013-04-01

    Full Text Available In continuum to my previous paper titled‘Implementation of plasmonics in VLSI’, this paperattempts to explore further, the actual physicalrealization of an all-plasmonic chip. In this paper,various methods of plasmon-basedphotolithography have been discussed and anobservation is made w.r.t the cost effectiveness andease of adaptability. Also, plasmonics based activeelement has been discussed which would helpunravel further arenas ofapproaches and methodstowards the realization of an all-plasmonic chip.

  4. Graphene-based nanodynamometer

    OpenAIRE

    Poklonski, N. A.; Siahlo, A. I.; Vyrko, S. A.; Popov, A. M.; Lozovik, Yu. E.; Lebedeva, I. V.; Knizhnik, A. A.

    2013-01-01

    A new concept of an electromechanical nanodynamometer based on the relative displacement of layers of bilayer graphene is proposed. In this nanodynamometer, force acting on one of the graphene layers causes the relative displacement of this layer and related change of conductance between the layers. Such a force can be determined by measurements of the tunneling conductance between the layers. Dependences of the interlayer interaction energy and the conductance between the graphene layers on ...

  5. Molecule-based magnets

    Indian Academy of Sciences (India)

    J V Yakhmi

    2009-06-01

    The conventional magnetic materials used in current technology, such as, Fe, Fe2O3, Cr2O3, SmCo5, Nd2Fe14B etc are all atom-based, and their preparation/processing require high temperature routes. Employing self-assembly methods, it is possible to engineer a bulk molecular material with long-range magnetic order, mainly because one can play with the weak intermolecular interactions. Since the first successful synthesis of molecular magnets in 1986, a large variety of them have been synthesized, which can be categorized on the basis of the chemical nature of the magnetic units involved: organic-, metal-based systems, heterobimetallic assemblies, or mixed organic–inorganic systems. The design of molecule-based magnets has also been extended to the design of poly-functional molecular magnets, such as those exhibiting second-order optical nonlinearity, liquid crystallinity, or chirality simultaneously with long-range magnetic order. Solubility, low density and biocompatibility are attractive features of molecular magnets. Being weakly coloured, unlike their opaque classical magnet ‘cousins’ listed above, possibilities of photomagnetic switching exist. Persistent efforts also continue to design the ever-elusive polymer magnets towards applications in industry. While providing a brief overview of the field of molecular magnetism, this article highlights some recent developments in it, with emphasis on a few studies from the author’s own lab.

  6. Internet Based Social Lending

    Directory of Open Access Journals (Sweden)

    Harsh Dhand

    2008-08-01

    Full Text Available Social lending is community-based lending. The “family and friends” loans community has been extended and formalized to create a marketplace of borrowers and lenders. In Internet-based Social Lending (IBSL, the company runs a website that connects potential lenders with potential borrowers. By removing the overheads and bulky infrastructure of the banking system, IBSL provides lenders a higher rate of return in exchange for only slightly higher risk. Borrowers here are those who are unsatisfied with the rates offered by banks or those that fall outside of the traditional banking systems due to unattractive credit ratings, high risk profiles or project-based, sporadic compensation. Borrowers are also attracted by the possibility of getting lower interest rates. We believe that this has the potential to impact the genesis of many small and medium level enterprises, besides providing a perennial source of financial leverage. The focus of this paper is not just the underlying technology and innovation, but also the market it creates. We take the example of one of the key players in the field, Zopa, and study its organization

  7. Microbead agglutination based assays

    KAUST Repository

    Kodzius, Rimantas

    2013-01-21

    We report a simple and rapid room temperature assay for point-of-care (POC) testing that is based on specific agglutination. Agglutination tests are based on aggregation of microbeads in the presence of a specific analyte thus enabling the macroscopic observation. Such tests are most often used to explore antibody-antigen reactions. Agglutination has been used for protein assays using a biotin/streptavidin system as well as a hybridization based assay. The agglutination systems are prone to selftermination of the linking analyte, prone to active site saturation and loss of agglomeration at high analyte concentrations. We investigated the molecular target/ligand interaction, explaining the common agglutination problems related to analyte self-termination, linkage of the analyte to the same bead instead of different microbeads. We classified the agglutination process into three kinds of assays: a two- component assay, a three-component assay and a stepped three- component assay. Although we compared these three kinds of assays for recognizing DNA and protein molecules, the assay can be used for virtually any molecule, including ions and metabolites. In total, the optimized assay permits detecting analytes with high sensitivity in a short time, 5 min, at room temperature. Such a system is appropriate for POC testing.

  8. Location-based games

    DEFF Research Database (Denmark)

    Ejsing-Duun, Stine

    In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception of and be......In this dissertation, it is explored which prerequisites are necessary in location-based games (LBGs) to make meaningful the meeting between players and spatiality with an emphasis on physical locations. Throughout the dissertation, it has been shown that LBGs affect players’ perception...... experiences of being in the world and the creation of meaning. The theory on motivation defines what motivation consists of and how it relates to our actions. This theory has been combined with theories concerning play and play culture, digital media, (digital) games, (optimal) experiences, landscape...... architecture, everyday practices (related to walking in the city), and the existing theories on LBGs as well as pervasive games. The methodological approach incorporates design-based research. It combines and aims at improving design, research, and practice concurrently. A design of an LBG – Visions of Sara...

  9. Knowledge-based utility

    International Nuclear Information System (INIS)

    This presentation provides industry examples of successful marketing practices by companies facing deregulation and competition. The common thread through the examples is that long term survival of today's utility structure is dependent on the strategic role of knowledge. As opposed to regulated monopolies which usually own huge physical assets and have very little intelligence about their customers, unregulated enterprises tend to be knowledge-based, characterized by higher market value than book value. A knowledge-based enterprise gathers data, creates information and develops knowledge by leveraging it as a competitive weapon. It institutionalizes human knowledge as a corporate asset for use over and over again by the use of databases, computer networks, patents, billing, collection and customer services (BCCS), branded interfaces and management capabilities. Activities to become knowledge-based such as replacing inventory/fixed assets with information about material usage to reduce expenditure and achieve more efficient operations, and by focusing on integration and value-adding delivery capabilities, were reviewed

  10. Route based forecasting

    Science.gov (United States)

    Zuurendonk, I. W.; Wokke, M. J. J.

    2009-09-01

    Road surface temperatures can differ several degrees on a very short distance due to local effects. In order to get more insight in the local temperature differences and to develop safer gritting routes, Meteogroup has developed a system for route based temperature forecasting. The standard version of the road model is addressed to forecast road surface temperature and condition for a specific location. This model consists of two parts. First a physical part, based on the energy balance equations. The second part of the model performs a statistical correction on the calculated physical road surface temperature. The road model is able to create a forecast for one specific location. From infrared measurements, we know that large local differences in road surface temperature exist on a route. Differences can be up to 5 degrees Celsius over a distance of several hundreds of meters. Based on those measurements, the idea came up to develop a system that forecasts road surface temperature and condition for an entire route: route based forecasting. The route is split up in sections with equal properties. For each section a temperature and condition will be calculated. The main factors that influence the road surface temperature are modelled in this forecasting system: •The local weather conditions: temperature, dew point temperature, wind, precipitation, weather type, cloudiness. •The sky view: A very sheltered place will receive less radiation during daytime and emit less radiation during nighttime. For a very open spot, the effects are reversed. •The solar view: A road section with trees on the southern side, will receive less solar radiation during daytime than a section with tress on the southern side. The route based forecast shows by means of a clear Google Maps presentation which sections will be slippery at what time of the coming night. The final goal of this type of forecast, is to make dynamical gritting possible: a variable salt amount and a different

  11. The Influence of the Combination of Carboxylate and Phosphinate Pendant Arms in 1,4,7-Triazacyclononane-Based Chelators on Their 68Ga Labelling Properties

    Directory of Open Access Journals (Sweden)

    Gábor Máté

    2015-07-01

    Full Text Available In order to compare the coordination properties of 1,4,7-triazacyclononane (tacn derivatives bearing varying numbers of phosphinic/carboxylic acid pendant groups towards 68Ga, 1,4,7-triazacyclononane-7-acetic-1,4-bis(methylenephosphinic acid (NOPA and 1,4,7- triazacyclononane-4,7-diacetic-1-[methylene(2-carboxyethylphosphinic] acid (NO2AP were synthesized using Mannich reactions with trivalent or pentavalent forms of H-phosphinic acids as phosphorus components. Stepwise protonation constants logK1–3 12.06, 3.90 and 1.95, and stability constants with GaIII and CuII, logKGaL 24.01 and logKCuL 16.66, were potentiometrically determined for NOPA. Both ligands were labelled with 68Ga and compared with NOTA (tacn-N,N′,N″-triacetic acid and NOPO, a TRAP-type [tacn-N,N′,N″- tris(methylenephosphinic acid] chelator. At pH 3, NOPO and NOPA showed higher labelling efficiency (binding with lower ligand excess at both room temperature and 95 °C, compared to NO2AP and NOTA. Labelling efficiency at pH = 0–3 correlated with a number of phosphinic acid pendants: NOPO >> NOPA > NO2AP >> NOTA; however, it was more apparent at 95 °C than at room temperature. By contrast, NOTA was found to be labelled more efficiently at pH > 4 compared to the ligands with phosphinic acids. Overall, replacement of a single phosphinate donor with a carboxylate does not challenge 68Ga labelling of TRAP-type chelators. However, the presence of carboxylates facilitates labelling at neutral or weakly acidic pH.

  12. Polyolefin-Based Aerogels

    Science.gov (United States)

    Lee, Je Kyun; Gould, George

    2012-01-01

    An organic polybutadiene (PB) rubberbased aerogel insulation material was developed that will provide superior thermal insulation and inherent radiation protection, exhibiting the flexibility, resiliency, toughness, and durability typical of the parent polymer, yet with the low density and superior insulation properties associated with the aerogels. The rubbery behaviors of the PB rubber-based aerogels are able to overcome the weak and brittle nature of conventional inorganic and organic aerogel insulation materials. Additionally, with higher content of hydrogen in their structure, the PB rubber aerogels will also provide inherently better radiation protection than those of inorganic and carbon aerogels. Since PB rubber aerogels also exhibit good hydrophobicity due to their hydrocarbon molecular structure, they will provide better performance reliability and durability as well as simpler, more economic, and environmentally friendly production over the conventional silica or other inorganic-based aerogels, which require chemical treatment to make them hydrophobic. Inorganic aerogels such as silica aerogels demonstrate many unusual and useful properties. There are several strategies to overcoming the drawbacks associated with the weakness and brittleness of silica aerogels. Development of the flexible fiber-reinforced silica aerogel composite blanket has proven one promising approach, providing a conveniently fielded form factor that is relatively robust toward handling in industrial environments compared to silica aerogel monoliths. However, the flexible silica aerogel composites still have a brittle, dusty character that may be undesirable, or even intolerable, in certain applications. Although the cross-linked organic aerogels such as resorcinol-formaldehyde (RF), polyisocyanurate, and cellulose aerogels show very high impact strength, they are also very brittle with little elongation (i.e., less rubbery). Also, silica and carbon aerogels are less efficient

  13. Characteristics Data Base

    International Nuclear Information System (INIS)

    The LWR Serial Numbers Database System (SNDB) contains detailed data about individual, historically discharged LWR spent fuel assemblies. This data includes the reactor where used, the year the assemblies were discharged, the pool where they are currently stored, assembly type, burnup, weight, enrichment, and an estimate of their radiological properties. This information is distributed on floppy disks to users in the nuclear industry to assist in planning for the permanent nuclear waste repository. This document describes the design and development of the SNDB. It provides a complete description of the file structures and an outline of the major code modules. It serves as a reference for a programmer maintaining the system, or for others interested in the technical detail of this database. This is the initial version of the SNDB. It contains historical data through December 31, 1987, obtained from the Energy Information Administration (EIA). EIA obtains the data from the utility companies via the RW-859 Survey Form. It evaluates and standardizes the data and distributes the resulting batch level database as a large file on magnetic tape. The Characteristics Data Base obtains this database for use in the LWR Quantities Data Base. Additionally, the CDB obtains the individual assembly level detail from EIA for use in the SNDB. While the Quantities Data Base retains only the level of detail necessary for its reporting, the SNDB does retain and use the batch level data to assist in the identification of a particular assembly serial number. We expect to update the SNDB on an annual basis, as new historical data becomes available

  14. Sustainability Base Construction Update

    Science.gov (United States)

    Mewhinney, Michael

    2012-01-01

    Construction of the new Sustainability Base Collaborative support facility, expected to become the highest performing building in the federal government continues at NASA's Ames Research Center, Moffet Field, Calif. The new building is designed to achieve a platinum rating under the leadership in Energy and Environment Design (LEED) new construction standards for environmentally sustainable construction developed by the U. S. Green Building Council, Washington, D. C. When completed by the end of 2011, the $20.6 million building will feature near zero net energy consumption, use 90 percent less potable water than conventionally build buildings of equivalent size, and will result in reduced building maintenance costs.

  15. Refractive index based measurements

    DEFF Research Database (Denmark)

    2014-01-01

    In a method for performing a refractive index based measurement of a property of a fluid such as chemical composition or temperature by observing an apparent angular shift in an interference fringe pattern produced by back or forward scattering interferometry, ambiguities in the measurement caused...... by the apparent shift being consistent with one of a number of numerical possibilities for the real shift which differ by 2n are resolved by combining measurements performed on the same sample using light paths therethrough of differing lengths....

  16. Problem Based Game Design

    DEFF Research Database (Denmark)

    Reng, Lars; Schoenau-Fog, Henrik

    2011-01-01

    At Aalborg University’s department of Medialogy, we are utilizing the Problem Based Learning method to encourage students to solve game design problems by pushing the boundaries and designing innovative games. This paper is concerned with describing this method, how students employ it in various...... projects and how they learn to analyse, design, and develop for innovation by using it. We will present various cases to exemplify the approach and focus on how the method engages students and aspires for innovation in digital entertainment and games....

  17. COMPUTER BASED ENVIRONMENT CONTROLS

    OpenAIRE

    Macoveiciuc Pastorel

    2011-01-01

    The aim of these notes is to give an overview of the main activities of computer based activities controls. The basic principles of computer controls should be common to all sectors and to most types of hardware and software. The absence of a common definition of computer control may, in part, be due to the relative newness of computer controls. A key feature of many organisations today is change. Although not necessarily the driver of change, IT is invariably an intrinsec component and much ...

  18. Vision-based interaction

    CERN Document Server

    Turk, Matthew

    2013-01-01

    In its early years, the field of computer vision was largely motivated by researchers seeking computational models of biological vision and solutions to practical problems in manufacturing, defense, and medicine. For the past two decades or so, there has been an increasing interest in computer vision as an input modality in the context of human-computer interaction. Such vision-based interaction can endow interactive systems with visual capabilities similar to those important to human-human interaction, in order to perceive non-verbal cues and incorporate this information in applications such

  19. Barium zirconate base ceramics

    International Nuclear Information System (INIS)

    The chemical corrosion at high temperatures is a serious problem in the refractory materials field, leading to degradation and bath contamination by elements of the refractory. The main objective of this work was to search for ceramics that could present higher resistance to chemical attack by aggressive molten oxides. The general behaviour of a ceramic material based on barium zirconate (Ba Zr O3) with the addition of different amounts of liquid phase former was investigated. The densification behaviour occurred during different heat treatments, as well as the microstructure development, as a function of the additives and their reactions with the main phase, were observed and are discussed. (author)

  20. Microcontroller based electronic load

    International Nuclear Information System (INIS)

    A microcontroller based electronic load has been designed and developed for testing of power supplies in CAT, Indore. This system is designed to operate in 4 different modes viz. constant current, constant power, constant resistance and constant resistance-inductance mode. This dynamic electronic load is very useful because a single load can be used in four different modes and different values can be emulated in each mode. It can be used as a switching load too. User interface has been provided to set the mode of operation and the set point during run time. (author)

  1. Speckle-based wavemeter

    DEFF Research Database (Denmark)

    Hanson, Steen Grüner; Jakobsen, Michael Linde; Chakrabarti, Maumita

    2015-01-01

    A spectrometer based on the application of dynamic speckles will be disclosed. The method relies on scattering of primarily coherent radiation from a slanted rough surface. The scattered radiation is collected on a detector array and the speckle displacement is monitored during a change in the...... incident wavelength. The change of wavelength gives an almost linear phaseshift across the scattering surface resulting in an almost linear shift of the speckle pattern, which is subsequently monitored. It is argued that frequency changes close to 100 MHz can be probed using a common CMOS array...

  2. Teradata data base computer

    Energy Technology Data Exchange (ETDEWEB)

    1984-04-01

    To meet the growing demand for information management of large databases, Teradata Corporation has introduced the DBC/1012 data base computer, an IBM plug-compatible system that can handle data volumes up to a trillion bytes. Teradata estimates the DBC/1012 to be one-third the cost of an all-software relational system on a general purpose mainframe. Cost effectiveness, as well as fault tolerance, is achieved by a parallel architecture which processes data asynchronously using multiple independent microprocessors. Another cost saving results from the resources on the host mainframe that become available once the mainframe is relieved of the burden of maintaining the database.

  3. Wood-Based Bioenergy

    OpenAIRE

    Hoel, Michael; Sletten, Thea Marcelia

    2014-01-01

    During recent years increased attention has been given to second-generation wood-based bioenergy. The carbon stored in the forest is highest when there is little or no harvest from the forest. Increasing the harvest from a forest, in order to produce more bioenergy, may thus conflict with the direct benefit of the forest as a carbon sink. We analyze this conflict using a simple model where bioenergy and fossil energy are perfect substitutes. Our analysis shows how the social optimum will depe...

  4. OCR Based Pixel Fusion

    Directory of Open Access Journals (Sweden)

    Rami Al-Hmouz

    2012-01-01

    Full Text Available Character recognition is the process that allows the automatic identification of character images, which is generally referred as Optical Character Recognition (OCR. The characters are either handwritten or typed. This study proposed a novel OCR approach based on the likelihood functions of pixels, which were obtained by averaging a trained set of character images. A Bayesian fusion process for all pixel probabilities decides the recognition of characters. Further tests using Support Vector Machine (SVM classifier were carried out on characters with the same shape. This method was used to test noisy images and achieved an accuracy of 97.95%, thus, outperforming other OCR methods.

  5. Technical Design Report BASE

    CERN Document Server

    Ulmer, S; Smorra, C; Blaum, K; Franke, K; Matsuda, Y; Nagahama, H; Quint, W; Walz, J; Mooser, A; Schneider, G; CERN. Geneva. SPS and PS Experiments Committee; SPSC

    2013-01-01

    We propose a direct high-precision measurement of the magnetic moment, or g-factor, of a single antiproton stored in a cryogenic Penning trap. Currently the most precise value of the magnetic moment of the antiproton is extracted from super-hyperfine spectroscopy of antiprotonic helium atoms, and known with a relative precision of only about 3 10^{-3}. BASE aims at a measurement with a relative precision of 10^{-9} or better. A Letter of Intent which was submitted to CERN was welcomed by the SPSC and we were invited to submit this Technical Design Report.

  6. Bi-based superconductor

    Directory of Open Access Journals (Sweden)

    S E Mousavi

    2009-08-01

    Full Text Available   In this paper, Bi-Sr-Ca-Cu-O (BCSCCO system superconductor is made by the solid state reaction method. The effect of doping Pb, Cd, Sb, Cu and annealing time on the critical temperature and critical current density have been investigated. The microstructure and morphology of the samples have been studied by X-ray diffraction, scanning electron microscope and energy dispersive X-ray. The results show that the fraction of Bi-2223 phase in the Bi- based superconductor, critical temperature and critical current density depend on the annealing temperature, annealing time and the kind and amount of doping .

  7. Agent-Based Optimization

    CERN Document Server

    Jędrzejowicz, Piotr; Kacprzyk, Janusz

    2013-01-01

    This volume presents a collection of original research works by leading specialists focusing on novel and promising approaches in which the multi-agent system paradigm is used to support, enhance or replace traditional approaches to solving difficult optimization problems. The editors have invited several well-known specialists to present their solutions, tools, and models falling under the common denominator of the agent-based optimization. The book consists of eight chapters covering examples of application of the multi-agent paradigm and respective customized tools to solve  difficult optimization problems arising in different areas such as machine learning, scheduling, transportation and, more generally, distributed and cooperative problem solving.

  8. RF Based Spy

    OpenAIRE

    Robot Prerna Jain; Pallavi N. Firke

    2014-01-01

    The intention of this paper is to reduce human victims in terrorist attack such as 26/11. So this problem can be overcome by designing the RF based spy robot which involves wireless camera. so that from this we can examine rivals when it required. This robot can quietly enter into enemy area and sends us the information via wireless camera. On the other hand one more feature is added in this robot that is colour sensor. Colour sensor senses the colour of surface and according ...

  9. Mars base buildup scenarios

    International Nuclear Information System (INIS)

    Two surface base build-up scenarios are presented in order to help visualize the mission and to serve as a basis for trade studies. In the first scenario, direct manned landings on the Martian surface occur early in the missions and scientific investigation is the main driver and rationale. In the second scenario, early development of an infrastructure to exploite the volatile resources of the Martian moons for economic purposes is emphasized. Scientific exploration of the surface is delayed at first, but once begun develops rapidly aided by the presence of a permanently manned orbital station

  10. Alphavirus-Based Vaccines.

    Science.gov (United States)

    Lundstrom, Kenneth

    2016-01-01

    Alphavirus vectors based on Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been widely applied for vaccine development. Naked RNA replicons, recombinant viral particles, and layered DNA vectors have been subjected to immunization in preclinical animal models with antigens for viral targets and tumor antigens. Moreover, a limited number of clinical trials have been conducted in humans. Vaccination with alphavirus vectors has demonstrated efficient immune responses and has showed protection against challenges with lethal doses of virus and tumor cells, respectively. Moreover, vaccines have been developed against alphaviruses causing epidemics such as Chikungunya virus. PMID:27076308

  11. WAP - based telemedicine applications

    International Nuclear Information System (INIS)

    Telemedicine refers to the utilization of telecommunication technology for medical diagnosis, treatment, and patient care. Its aim is to provide expert-based health care to remote sites through telecommunication and information technologies. The significant advances in technologies have enabled the introduction of a broad range of telemedicine applications, which are supported by computer networks, wireless communication, and information superhighway. For example, some hospitals are using tele-radiology for remote consultation. Such a system includes medical imaging devices networked with computers and databases. Another growing area is patient monitoring, in which sensors are used to acquire biomedical signals, such as electrocardiogram (ECG), blood pressure, and body temperature, from a remote patient, who could be in bed or moving freely. The signals are then relayed to remote systems for viewing and analysis. Telemedicine can be divided into two basic modes of operations: real-time mode, in which the patient data can be accessed remotely in real-time, and store-and-forward mode, in which the acquired data does not have to be accessed immediately. In the recent years, many parties have demonstrated various telemedicine applications based on the Internet and cellular phone as these two fields have been developing rapidly. A current, recognizable trend in telecommunication is the convergence of wireless communication and computer network technologies. This has been reflected in recently developed telemedicine systems. For example, in 1998 J. Reponen, et al. have demonstrated transmission and display of computerized tomography (CT) examinations using a remote portable computer wirelessly connected to a computer network through TCP/IP on a GSM cellular phone. Two years later, they carried out the same tests with a GSM-based wireless personal digital assistant (PDA). The WAP (Wireless Application Protocol) Forum was founded in 1997 to create a global protocol

  12. Cellular based cancer vaccines

    DEFF Research Database (Denmark)

    Hansen, Morten; Met, O; Svane, I M;

    2012-01-01

    Cancer vaccines designed to re-calibrate the existing host-tumour interaction, tipping the balance from tumor acceptance towards tumor control holds huge potential to complement traditional cancer therapies. In general, limited success has been achieved with vaccines composed of tumor...... in vitro migration via autocrine receptor-mediated endocytosis of CCR7. In the current review, we discuss optimal design of DC maturation focused on pre-clinical as well as clinical results from standard and polarized dendritic cell based cancer vaccines....

  13. Pitch Based Sound Classification

    OpenAIRE

    Nielsen, Andreas Brinch; Hansen, Lars Kai; Kjems, U.

    2006-01-01

    A sound classification model is presented that can classify signals into music, noise and speech. The model extracts the pitch of the signal using the harmonic product spectrum. Based on the pitch estimate and a pitch error measure, features are created and used in a probabilistic model with soft-max output function. Both linear and quadratic inputs are used. The model is trained on 2 hours of sound and tested on publicly available data. A test classification error below 0.05 with 1 s classif...

  14. Moon base reactor system

    Science.gov (United States)

    Chavez, H.; Flores, J.; Nguyen, M.; Carsen, K.

    1989-01-01

    The objective of our reactor design is to supply a lunar-based research facility with 20 MW(e). The fundamental layout of this lunar-based system includes the reactor, power conversion devices, and a radiator. The additional aim of this reactor is a longevity of 12 to 15 years. The reactor is a liquid metal fast breeder that has a breeding ratio very close to 1.0. The geometry of the core is cylindrical. The metallic fuel rods are of beryllium oxide enriched with varying degrees of uranium, with a beryllium core reflector. The liquid metal coolant chosen was natural lithium. After the liquid metal coolant leaves the reactor, it goes directly into the power conversion devices. The power conversion devices are Stirling engines. The heated coolant acts as a hot reservoir to the device. It then enters the radiator to be cooled and reenters the Stirling engine acting as a cold reservoir. The engines' operating fluid is helium, a highly conductive gas. These Stirling engines are hermetically sealed. Although natural lithium produces a lower breeding ratio, it does have a larger temperature range than sodium. It is also corrosive to steel. This is why the container material must be carefully chosen. One option is to use an expensive alloy of cerbium and zirconium. The radiator must be made of a highly conductive material whose melting point temperature is not exceeded in the reactor and whose structural strength can withstand meteor showers.

  15. Accelerator-based BNCT

    International Nuclear Information System (INIS)

    The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. In particular, the present status and recent progress of the Argentine project will be reviewed. The topics will cover: intense ion sources, accelerator tubes, transport of intense beams, beam diagnostics, the 9Be(d,n) reaction as a possible neutron source, Beam Shaping Assemblies (BSA), a treatment room, and treatment planning in realistic cases. - Highlights: • The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. • Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. • The present status and recent progress of the Argentine project will be reviewed. • Topics cover intense ion sources, accelerator tubes, transport of intense beams and beam diagnostics, among others

  16. Model Based Definition

    Science.gov (United States)

    Rowe, Sidney E.

    2010-01-01

    In September 2007, the Engineering Directorate at the Marshall Space Flight Center (MSFC) created the Design System Focus Team (DSFT). MSFC was responsible for the in-house design and development of the Ares 1 Upper Stage and the Engineering Directorate was preparing to deploy a new electronic Configuration Management and Data Management System with the Design Data Management System (DDMS) based upon a Commercial Off The Shelf (COTS) Product Data Management (PDM) System. The DSFT was to establish standardized CAD practices and a new data life cycle for design data. Of special interest here, the design teams were to implement Model Based Definition (MBD) in support of the Upper Stage manufacturing contract. It is noted that this MBD does use partially dimensioned drawings for auxiliary information to the model. The design data lifecycle implemented several new release states to be used prior to formal release that allowed the models to move through a flow of progressive maturity. The DSFT identified some 17 Lessons Learned as outcomes of the standards development, pathfinder deployments and initial application to the Upper Stage design completion. Some of the high value examples are reviewed.

  17. Design Based Wilderness Education

    Directory of Open Access Journals (Sweden)

    Christopher R. Saulnier

    2015-02-01

    Full Text Available The Massachusetts Institute of Technology (MIT has been collaborating since 2010 with the Singapore Ministry of Education to help develop the Singapore University of Technology and Design (SUTD. One element of this collaboration, the Global Leadership Program (GLP, aims to provide SUTD students with the opportunity to interact with the MIT community and experience MIT’s academic culture. During GLP students participate in a program designed to develop leadership ability while also increasing their understanding of engineering science and design thinking. This paper introduces a curriculum combining the pedagogies of design-based learning and wilderness education that was implemented in the summer of 2014 to holistically address the development of these three competencies. Through design-based learning activities, both for and in a natural environment, students were encouraged to develop competencies in engineering science and engineering design while exploring the diverse attributes essential for success as an engineer. This paper examines the results of a retrospective post-then-pre survey administered to the participants upon completion of the program to explore the effects of the program on the development of professional engineering competencies. We find a statistically significant increase in items associated with Individual Leadership Skill, Group Leadership Skill and the role of Society and the Economy. These results are triangulated with student exit interviews and instructor observations.

  18. Challenge Based Innovation gala

    CERN Document Server

    CERN. Geneva; Utriainen, Tuuli Maria; Toivonen, Harri; Nordberg, Markus

    2014-01-01

    Challenge Based Innovation gala   There’s a new experiment starting in CERN called IdeaLab where we work together with detector R&D researchers to help them to bridge their knowledge into a more human, societally oriented context. Currently we are located in B153, but will move our activities to a new facility next to the Globe in May 2014. One of our first pilot projects is a 5 month course CBI (Challenge Based Innovation) where two multidisciplinary student teams join forces with Edusafe & TALENT projects at CERN. Their goal is to discover what kind of tools for learning could be created in collaboration with the two groups. After months of user interviews and low resolution prototyping they are ready to share the results with us in the form of an afternoon gala. We warmly welcome you to join us to see the students' results and experience the prototypes they have conceived. The event is in three parts, you are welcome to visit all of them,...

  19. Microlaser-based displays

    Science.gov (United States)

    Bergstedt, Robert; Fink, Charles G.; Flint, Graham W.; Hargis, David E.; Peppler, Philipp W.

    1997-07-01

    Laser Power Corporation has developed a new type of projection display, based upon microlaser technology and a novel scan architecture, which provides the foundation for bright, extremely high resolution images. A review of projection technologies is presented along with the limitations of each and the difficulties they experience in trying to generate high resolution imagery. The design of the microlaser based projector is discussed along with the advantage of this technology. High power red, green, and blue microlasers have been designed and developed specifically for use in projection displays. These sources, in combination with high resolution, high contrast modulator, produce a 24 bit color gamut, capable of supporting the full range of real world colors. The new scan architecture, which reduces the modulation rate and scan speeds required, is described. This scan architecture, along with the inherent brightness of the laser provides the fundamentals necessary to produce a 5120 by 4096 resolution display. The brightness and color uniformity of the display is excellent, allowing for tiling of the displays with far fewer artifacts than those in a traditionally tiled display. Applications for the display include simulators, command and control centers, and electronic cinema.

  20. Knowledge Based Economy Assessment

    Directory of Open Access Journals (Sweden)

    Madalina Cristina Tocan

    2012-12-01

    Full Text Available The importance of knowledge-based economy (KBE in the XXI century isevident. In the article the reflection of knowledge on economy is analyzed. The main point is targeted to the analysis of characteristics of knowledge expression in economy and to the construction of structure of KBE expression. This allows understanding the mechanism of functioning of knowledge economy. Theauthors highlight the possibility to assess the penetration level of KBE which could manifest itself trough the existence of products of knowledge expression which could be created in acquisition, creation, usage and development of them. The latter phenomenon is interpreted as knowledge expression characteristics: economic and social context, human resources, ICT, innovative business and innovation policy. The reason for this analysis was based on the idea that in spite of the knowledge economy existence in all developed World countries adefinitive, universal list of indicators for mapping and measuring the KBE does not yet exists. Knowledge Expression Assessment Models are presented in the article.

  1. Constraint-based reachability

    Directory of Open Access Journals (Sweden)

    Arnaud Gotlieb

    2013-02-01

    Full Text Available Iterative imperative programs can be considered as infinite-state systems computing over possibly unbounded domains. Studying reachability in these systems is challenging as it requires to deal with an infinite number of states with standard backward or forward exploration strategies. An approach that we call Constraint-based reachability, is proposed to address reachability problems by exploring program states using a constraint model of the whole program. The keypoint of the approach is to interpret imperative constructions such as conditionals, loops, array and memory manipulations with the fundamental notion of constraint over a computational domain. By combining constraint filtering and abstraction techniques, Constraint-based reachability is able to solve reachability problems which are usually outside the scope of backward or forward exploration strategies. This paper proposes an interpretation of classical filtering consistencies used in Constraint Programming as abstract domain computations, and shows how this approach can be used to produce a constraint solver that efficiently generates solutions for reachability problems that are unsolvable by other approaches.

  2. BIOMETRICS BASED USER AUTHENTICATION

    Directory of Open Access Journals (Sweden)

    Tanuj Tiwari

    2015-10-01

    Full Text Available Biometrics is automated methods of recognizing a person based on a physiological or behavioral characteristic. Biometrics technologies are base for a plethora of highly secure identification and personal verification solutions. It is measurement of biological characteristics – either physiological or behavioral – that verify the claimed identity of an individual. Physiological biometrics include fingerprints, iris recognition. voice verification, retina recognition, palm vein patterns, finger vein patterns, hand geometry and DNA But there arises a need for more robust systems in order to tackle the increasing incidents of security breaches and frauds. So there is always a need for fool proof technology that can provide security and safety to individuals and the transactions that the individuals make. Biometrics is increasingly used by organizations to verify identities, but coupled with quantum cryptography it offers a new range of security benefits with quantum cryptography where we form a key when we need it and then destroy it. In this paper, we give a brief overview of the field of biometrics and summarize some of its advantages, disadvantages, strengths, limitations, and related privacy concerns.

  3. Workplace Based Assessment in Psychiatry

    OpenAIRE

    Ayse Devrim Basterzi; O. Surel Karabilgin

    2009-01-01

    Workplace based assessment refers to the assessment of working practices based on what doctors actually do in the workplace, and is predominantly carried out in the workplace itself. Assessment drives learning and it is therefore essential that workplace-based assessment focuses on important attributes rather than what is easiest to assess. Workplacebased assessment is usually competency based. Workplace based assesments may well facilitate and enhance various aspects of educational supervisi...

  4. Synthesis, antitumor and antimicrobial activity of novel 1-substituted phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazole-5-yl] beta-carboline derivatives

    International Nuclear Information System (INIS)

    With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazole-5-yl) beta-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activities of 1a-c and of 2-7(a-c) were also evaluated. Additionally, an in silico study of the ADME properties of novel synthesized beta-carboline derivatives 2-7(a-c) was performed by evaluation of their Lipinski's parameters and topological polar surface area (TPSA) and percentage of absorption (% ABS) data. (author)

  5. Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives

    Directory of Open Access Journals (Sweden)

    P. C. Jagadish

    2013-01-01

    Full Text Available Mannich base of pyrazolines 3(a–e under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy. The result obtained confirms superiority of microwave irradiation method over classical heating one. The molecular properties and Lipinski rule of five for compounds 3(a–e were determined by Molinspiration. The synthesized compounds were subsequently evaluated for the antioxidant activity. All the compounds were found in compliance with Lipinski “Rule of Five”, and compound 3e having p-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin.

  6. Facile green synthesis and potent antimicrobial efficacy of -aminoheteronapthol via tailored Betti’s protocol and their bis-aryl hydrazone click products

    Indian Academy of Sciences (India)

    K M Khandarkar; M D Shanti; M Ahmed; J S Meshram

    2013-11-01

    A series of novel Mannich base and their hydrazone derivatives were synthesized by highly resourceful, chic, simple and green technique with exceptionally facile reaction conditions of one-pot, three component reaction with an array of biologically and pharmaceutically active novel heterocycles. The protocol offers a valuable alternative to known methods and will find applications in the field of green synthesis and antimicrobial study against pathogenic microbes, supporting the development of bioinformatical database of novel and derelict heterocycles. These data indicate their potential to become antifungal agents. The novel products were established by elemental, IR, mass spectroscopic and NMR analysis. The environmental advantages of the method include short reaction time, excellent yield, easy work-up, absence of extraction and chromatographic purification steps.

  7. 1,2,4-oxadiazole nucleus with versatile biological applications

    Directory of Open Access Journals (Sweden)

    Mohammad Arshad

    2014-07-01

    Full Text Available Azoles are the five-membered heterocyclic compounds with two or three nitrogen atoms, constitute a large group of organic substances and have been long targeted for their use as therapeutic agents. 1,2,4-oxadiazoles is a member of azole family containing two nitrogen atoms, two carbon and one oxygen atom in the ring.1,2,4- oxadiazoles have been found to possess variety of biological activities such as human tryptase inhibitory activity, antitrypanosomal activity, β-amyloid imaging agents in Alzheimer’s disease, genotoxic activity, peptide inhibitory activity, antihyperglycemic activity, potential combretastatin A-4 (CA-4 analogs and oxadiazole mannich bases show antimyco-bacterial activity. Here in this review article we have reported the recent development in the pharmacological activity of some newly synthesized 1,2,4-oxadiazole derivatives.

  8. PREPARACIÓN DE 3,4 –DIHIDRO 1.3.2H-NAFTOXAZINAS

    Directory of Open Access Journals (Sweden)

    José M. Rincón

    2010-09-01

    Full Text Available El presente trabajo es una extensión de las investigaciones iniciadas por Burke sobre las reacciones entre fenoles, aminas primarías y formaldehído para la obtención de benzoxazinas. Se aplica el mismo procedimiento general para la obtención de naftoxazinas a partir de alfa naftoles sustituidos en la posición cuatro. Se postula una posible vía de formación del anillo heterocíclico a través de la base de Mannich como un intermedio. Además se asignan las bandas de absorción infrarroja debidas a la tensión Cnaftil-0, lo mismo que el desplazamiento químico de los protones del anillo heterocíclico.

  9. MS Based Metabonomics

    Energy Technology Data Exchange (ETDEWEB)

    Want, Elizabeth J.; Metz, Thomas O.

    2010-03-01

    Metabonomics is the latest and least mature of the systems biology triad, which also includes genomics and proteomics, and has its origins in the early orthomolecular medicine work pioneered by Linus Pauling and Arthur Robinson. It was defined by Nicholson and colleagues in 1999 as the quantitative measurement of perturbations in the metabolite complement of an integrated biological system in response to internal or external stimuli, and is often used today to describe many non-global types of metabolite analyses. Applications of metabonomics are extensive and include toxicology, nutrition, pharmaceutical research and development, physiological monitoring and disease diagnosis. For example, blood samples from millions of neonates are tested routinely by mass spectrometry (MS) as a diagnostic tool for inborn errors of metabolism. The metabonome encompasses a wide range of structurally diverse metabolites; therefore, no single analytical platform will be sufficient. Specialized sample preparation and detection techniques are required, and advances in NMR and MS technologies have led to enhanced metabonome coverage, which in turn demands improved data analysis approaches. The role of MS in metabonomics is still evolving as instrumentation and software becomes more sophisticated and as researchers realize the strengths and limitations of current technology. MS offers a wide dynamic range, high sensitivity, and reproducible, quantitative analysis. These attributes are essential for addressing the challenges of metabonomics, as the range of metabolite concentrations easily exceeds nine orders of magnitude in biofluids, and the diversity of molecular species ranges from simple amino and organic acids to lipids and complex carbohydrates. Additional challenges arise in generating a comprehensive metabolite profile, downstream data processing and analysis, and structural characterization of important metabolites. A typical workflow of MS-based metabonomics is shown in Figure

  10. Space-Based Range

    Science.gov (United States)

    2008-01-01

    Space-Based Range (SBR), previously known as Space-Based Telemetry and Range Safety (STARS), is a multicenter NASA proof-of-concept project to determine if space-based communications using NASA's Tracking and Data Relay Satellite System (TDRSS) can support the Range Safety functions of acquiring tracking data and generating flight termination signals, while also providing broadband Range User data such as voice, video, and vehicle/payload data. There was a successful test of the Range Safety system at Wallops Flight Facility (WFF) on December 20, 2005, on a two-stage Terrier-Orion spin-stabilized sounding rocket. SBR transmitted GPS tracking data and maintained links with two TDRSS satellites simultaneously during the 10-min flight. The payload section deployed a parachute, landed in the Atlantic Ocean about 90 miles downrange from the launch site, and was successfully recovered. During the Terrier-Orion tests flights, more than 99 percent of all forward commands and more than 95 percent of all return frames were successfully received and processed. The time latency necessary for a command to travel from WFF over landlines to White Sands Complex and then to the vehicle via TDRSS, be processed onboard, and then be sent back to WFF was between 1.0 s and 1.1 s. The forward-link margins for TDRS-10 (TDRS East [TDE]) were 11 dB to 12 dB plus or minus 2 dB, and for TDRS-4 (TDRS Spare [TDS]) were 9 dB to 10 dB plus or minus 1.5 dB. The return-link margins for both TDE and TDS were 6 dB to 8 dB plus or minus 3 dB. There were 11 flights on an F-15B at Dryden Flight Research Center (DFRC) between November 2006 and February 2007. The Range User system tested a 184-element TDRSS Ku-band (15 GHz) phased-array antenna with data rates of 5 Mbps and 10 Mbps. This data was a combination of black-and-white cockpit video, Range Safety tracking and transceiver data, and aircraft and antenna controller data streams. IP data formatting was used.

  11. Nanocrystalline copper based microcomposites

    Directory of Open Access Journals (Sweden)

    J.P. Stobrawa

    2012-09-01

    Full Text Available Purpose: The aim of this work was to investigate microstructure, mechanical properties and deformation behavior of copper microcomposites: Cu- Y2O3, Cu- ZrO2 and Cu-WC produced by powder metallurgy techniques.Design/methodology/approach: Tests were made with Cu-Y2O3, Cu-ZrO2 and Cu-WC microcomposites containing up to 2% of a strengthening phase. The materials were fabricated by powder metallurgy techniques, including milling of powders, followed by their compacting and sintering. The main mechanical properties of the materials were determined from the compression test and, additionally, measurements of HV hardness and electrical conductivity were made. Analysis of the initial nanocrystalline structure of these materials was made and its evolution during sintering and cold deformation was investigated.Findings: It was found out that addition of up to 2 wt.% of a strengthening phase significantly improves mechanical properties of the material and increases its softening point. The obtained strengthening effect have been discussed based on the existing theories related to strengthening of nanocrystalline materials. The studies have shown importance of “flows” existing in the consolidated materials and sintered materials in pores or regions of poor powder particle connection which significantly deteriorate the mechanical properties of microcomposites produced by powder metallurgy.Research limitations/implications: The powder metallurgy techniques make it possible to obtain copperbased bulk materials by means of input powder milling in a planetary ball mill, followed by compacting and sintering. Additional operations of hot extrusion are also often used. There is some danger, however, that during high-temperature processing or application of these materials at elevated or high temperatures this nanometric structure may become unstable.Practical implications: A growing trend to use new copper based microcomposites is observed recently worldwide

  12. Mucin-Based Vaccines

    Science.gov (United States)

    Richardson, Jonathan P.; MacMillan, Derek

    Mucins are heavily O-glycosylated cell surface and secreted glycoproteins . In addition to orchestrating cell-extracellular matrix and cell-cell interactions in healthy organisms mucins are also the major carriers of altered glycosylation in carcinomas. Tumor-associated antigens displayed by cancer cells comprise oligosaccharide and glycopeptide motifs not encountered in the same locale or at the same frequency in healthy cells, and potentially confer a selective advantage to the tumor. Frequently tumor-associated antigens are under-glycosylated and prematurely sialylated, and it is these relatively simple saccharide and glycopeptide structures that have been targeted to serve as drug candidates in most cases. A major goal is to assemble glycopeptide vaccine candidates based on partial mucin sequences and displaying tumor-associated antigens that can mount a potent immunological tumor-specific response when, in reality, the tumor has already coerced the immune system into a state of co-existence.

  13. Situation based housing

    DEFF Research Database (Denmark)

    Duelund Mortensen, Peder; Welling, Helen; Wiell Nordberg, Lene;

    2007-01-01

    variety of approaches to these goals. This working paper reviews not only a selection of new housing types, but also dwellings from the past, which each contain an aspect of changeability. Our study is based on information from users in the selected housing schemes, gathered from questionnaires...... the average family's lifestyle. These dwellings were ground-breaking when they were built, but today are clearly a product of their time. The reaction to functionalism and the postwar mass production gave rise to flexible dwelling with countless possibilities for room division. The housing of this...... period has characteristics which in the long run have proven to be unfortunate both in terms in terms of durability and architectural quality. Today there is a focus on the development of more open and functionally non-determined housing. A number of new housing schemes in and around Copenhagen reveal a...

  14. Touching base with OPERA

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Three seminars – at CERN, at Gran Sasso and in Japan – and an article calling for the scrutiny of the scientific community: the OPERA Collaboration opened its research publicly. In addition to huge press coverage, this triggered welcome reactions from colleagues around the world, many of whom will attempt to independently interpret and reproduce the measurement. OPERA’s Spokesperson touches base with the Bulletin.   The CERN Main Auditorium was crowded as OPERA Physics co-ordinator Dario Autiero presented the results of their research (23 September 2011). According to the OPERA strategy, the results of the measurements are in the hands of the scientific community and, as for any other scientific result, several months will be needed before other groups will be able to perform an independent measurement. In the meantime, the OPERA Collaboration is dealing with an avalanche of emails from the scientific community, members of the general public, and the press. &...

  15. Plasma based accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Caldwell, Allen [Max-Planck-Institut fuer Physik, Muenchen (Germany)

    2015-05-01

    The concept of laser-induced plasma wakefields as a technique to accelerate charged particles was introduced 35 years ago as a means to go beyond the accelerating gradients possible with metallic cavities supporting radio frequency electromagnetic fields. Significant developments in laser technology have made possible the pulse intensity needed to realize this concept, and rapid progress is now underway in the realization of laser-driven plasma wakefield acceleration. It has also been realized that similar accelerating gradients can be produced by particle beams propagating in plasmas, and experimental programs have also been undertaken to study this possibility. Positive results have been achieved with electron-driven plasma wakefields, and a demonstration experiment with proton-driven wakefields is under construction at CERN. The concepts behind these different schemes and their pros and cons are described, as well as the experimental results achieved. An outlook for future practical uses of plasma based accelerators will also be given.

  16. Integrated data base program

    International Nuclear Information System (INIS)

    The IDB Program provides direct support to the DOE Nuclear Waste Management and Fuel Cycle Programs and their lead sites and support contractors by providing and maintaining a current, integrated data base of spent fuel and radioactive waste inventories and projections. All major waste types (HLW, TRU, and LLW) and sources (government, commerical fuel cycle, and I/I) are included. A major data compilation was issued in September, 1981: Spent Fuel and Radioactive Waste Inventories and Projections as of December 31, 1980, DOE/NE-0017. This report includes chapters on Spent Fuel, HLW, TRU Waste, LLW, Remedial Action Waste, Active Uranium Mill Tailings, and Airborne Waste, plus Appendices with more detailed data in selected areas such as isotopics, radioactivity, thermal power, projections, and land usage. The LLW sections include volumes, radioactivity, thermal power, current inventories, projected inventories and characteristics, source terms, land requirements, and a breakdown in terms of government/commercial and defense/fuel cycle/I and I

  17. Al - BASED CAST COMPOSITES

    Directory of Open Access Journals (Sweden)

    Rakesh Kumar Yadav

    2011-08-01

    Full Text Available The economy is very important feature nowadays in themarket. The researches are playing an important role inengineering field to increase the life of machine parts /components and decrease the cost. The compositematerials have the potential to replace widely used steeland aluminium due to their good characteristics withbetter performance. The Al-based composites have foundextensive applications in automobile industries andaerospace industries due to their increased stiffness,strength, thermal conductivity and wear resistanceproperties. A number of particulate phases have beenemployed in the Al-alloy matrix. The cast aluminiumceramicparticulate composites are finding applications inpistons, connecting rods, cylinder liner, engine cylinderblock, electrical contacts etc.The present investigation isbased on study of the effect of particulate phase on theSEM study, micro-hardness, elastic modulus, tensilestrength and the wear behaviour of Al-5 % SiC-7 % Fe,Al-10 % SiC-6 % Fe and Al-15 % SiC-5 % Fe composites.

  18. Space-based detectors

    DEFF Research Database (Denmark)

    Sesana, A.; Weber, W. J.; Killow, C. J.;

    2014-01-01

    planned for 2015. This mission and its payload “LISA Technology Package” will demonstrate key technologies for LISA. In this context, reference masses in free fall for LISA, and gravitational physics in general, was described by William Weber, laser interferometry at the pico-metre level and the optical......The parallel session C5 on Space-Based Detectors gave a broad overview over the planned space missions related to gravitational wave detection. Overviews of the revolutionary science to be expected from LISA was given by Alberto Sesana and Sasha Buchman. The launch of LISA Pathfinder (LPF) is...... bench of LPF was presented by Christian Killow and the performance of the LPF optical metrology system by Paul McNamara. While LPF will not yet be sensitive to gravitational waves, it may nevertheless be used to explore fundamental physics questions, which was discussed by Michele Armano. Some parts of...

  19. Base isolation: Fresh insight

    Energy Technology Data Exchange (ETDEWEB)

    Shustov, V.

    1993-07-15

    The objective of the research is a further development of the engineering concept of seismic isolation. Neglecting the transient stage of seismic loading results in a widespread misjudgement: The force of resistance associated with velocity is mostly conceived as a source of damping vibrations, though it is an active force at the same time, during an earthquake type excitation. For very pliant systems such as base isolated structures with relatively low bearing stiffness and with artificially added heavy damping mechanism, the so called `damping`` force may occur even the main pushing force at an earthquake. Thus, one of the two basic pillars of the common seismic isolation philosophy, namely, the doctrine of usefulness and necessity of a strong damping mechanism, is turning out to be a self-deception, sometimes even jeopardizing the safety of structures and discrediting the very idea of seismic isolation. There is a way out: breaking with damping dependancy.

  20. Graphene based biosensors

    Science.gov (United States)

    Gürel, Hikmet Hakan; Salmankurt, Bahadır

    2016-03-01

    Nanometer-sized graphene as a 2D material has unique chemical and electronic properties. Because of its unique physical, chemical, and electronic properties, its interesting shape and size make it a promising nanomaterial in many biological applications. It is expected that biomaterials incorporating graphene will be developed for the graphene-based drug delivery systems and biomedical devices. The interactions of biomolecules and graphene are long-ranged and very weak. Development of new techniques is very desirable for design of bioelectronics sensors and devices. In this work, we present first-principles calculations within density functional theory to calculate effects of charging on nucleobases on graphene. It is shown that how modify structural and electronic properties of nucleobases on graphene by applied charging.

  1. PROcess Based Diagnostics PROBE

    Science.gov (United States)

    Clune, T.; Schmidt, G.; Kuo, K.; Bauer, M.; Oloso, H.

    2013-01-01

    Many of the aspects of the climate system that are of the greatest interest (e.g., the sensitivity of the system to external forcings) are emergent properties that arise via the complex interplay between disparate processes. This is also true for climate models most diagnostics are not a function of an isolated portion of source code, but rather are affected by multiple components and procedures. Thus any model-observation mismatch is hard to attribute to any specific piece of code or imperfection in a specific model assumption. An alternative approach is to identify diagnostics that are more closely tied to specific processes -- implying that if a mismatch is found, it should be much easier to identify and address specific algorithmic choices that will improve the simulation. However, this approach requires looking at model output and observational data in a more sophisticated way than the more traditional production of monthly or annual mean quantities. The data must instead be filtered in time and space for examples of the specific process being targeted.We are developing a data analysis environment called PROcess-Based Explorer (PROBE) that seeks to enable efficient and systematic computation of process-based diagnostics on very large sets of data. In this environment, investigators can define arbitrarily complex filters and then seamlessly perform computations in parallel on the filtered output from their model. The same analysis can be performed on additional related data sets (e.g., reanalyses) thereby enabling routine comparisons between model and observational data. PROBE also incorporates workflow technology to automatically update computed diagnostics for subsequent executions of a model. In this presentation, we will discuss the design and current status of PROBE as well as share results from some preliminary use cases.

  2. Base Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett Sondreal; John Hendrikson

    2009-03-31

    In June 2009, the Energy & Environmental Research Center (EERC) completed 11 years of research under the U.S. Department of Energy (DOE) Base Cooperative Agreement No. DE-FC26-98FT40320 funded through the Office of Fossil Energy (OFE) and administered at the National Energy Technology Laboratory (NETL). A wide range of diverse research activities were performed under annual program plans approved by NETL in seven major task areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, (6) advanced materials, and (7) strategic studies. This report summarizes results of the 67 research subtasks and an additional 50 strategic studies. Selected highlights in the executive summary illustrate the contribution of the research to the energy industry in areas not adequately addressed by the private sector alone. During the period of performance of the agreement, concerns have mounted over the impact of carbon emissions on climate change, and new programs have been initiated by DOE to ensure that fossil fuel resources along with renewable resources can continue to supply the nation's transportation fuel and electric power. The agreement has addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration while expanding the supply and use of domestic energy resources for energy security. It has further contributed to goals for near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources (e.g., wind-, biomass-, and coal-based electrical generation).

  3. The office based CHIVA

    Directory of Open Access Journals (Sweden)

    Passariello F

    2013-09-01

    Full Text Available Fausto Passariello,1 Stefano Ermini,2 Massimo Cappelli,3 Roberto Delfrate,4 Claude Franceschi5 1Centro Diagnostico Aquarius, Napoli, Italy; 2Private Practice, Grassina, Italy; 3Private Practice, Firenze, Italy; 4Casa di Cure Figlie di Maria, Cremona, Italy; 5Hospital St Joseph, Service d'Explorations Vasculaires, Paris, France Abstract: The cure Conservatrice Hémodynamique de l'Insuffisance Veineuse en Ambulatoire (CHIVA can be office based (OB. The OB-CHIVA protocol is aimed at transferring CHIVA procedures to specialists rooms. The protocol will check the feasibility of OB-CHIVA, data pertaining to recurrence, and will offer the opportunity to study saphenous femoral junction (SFJ stump evolution, the role of the washing vessels and the arch recanalization rate, and gather new data about the effect of the length of the treated saphenous vein. A simplified diagnostic procedure will allow an essential ultrasound examination of the venous net while a schematic and easily readable algorithm guides therapeutic choices. The Riobamba draining crossotomy (RDC tactic is composed of a set of OB procedures. While some of these procedures are, at the moment, only proposals, others are already applied. Devices generally used in ablative procedures such as Light Amplification by Stimulated Emission of Radiation (LASER, radio frequency, steam, and mechanical devices are used in this context to serve to conservative interventions for CHIVA. New techniques have also been proposed for devalvulation and tributary disconnection. Detailed follow-up is necessary in order to determine the effects of therapy and possible disease evolution. Finally, information is added about the informed consent and the ethical considerations of OB-CHIVA research. Keywords: CHIVA, office based procedures, LASER, RF, steam

  4. Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl-1,2,4-triazole-3-thiols

    Directory of Open Access Journals (Sweden)

    Al-Abdullah ES

    2014-05-01

    Full Text Available Ebtehal S Al-Abdullah,1 Hanadi H Asiri,1 Siham Lahsasni,2 Elsayed E Habib,3 Tarek M Ibrahim,4 Ali A El-Emam1 1Department of Pharmaceutical Chemistry, College of Pharmacy, 2Department of Chemistry, College of Sciences, King Saud University, Riyadh, 3Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, Medinah, Saudi Arabia; 4Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt Abstract: The reaction of 5-(1-adamantyl-4-phenyl-1,2,4-triazoline-3-thione (compound 5 with formaldehyde and 1-substituted piperazines yielded the corresponding N-Mannich bases 6a–f. The reaction of 5-(1-adamantyl-4-methyl-1,2,4-triazoline-3-thione 8 with various 2-aminoethyl chloride yielded separable mixtures of the S-(2-aminoethyl 9a–d and the N-(2-aminoethyl 10a–d derivatives. The reaction of compound 5 with 1-bromo-2-methoxyethane, various aryl methyl halides, and ethyl bromoacetate solely yielded the S-substituted products 11, 12a–d, and 13. The new compounds were tested for activity against a panel of Gram-positive and Gram-negative bacteria and the pathogenic fungus Candida albicans. Compounds 6b, 6c, 6d, 6e, 6f, 10b, 10c, 10d, 12c, 12d, 12e, 13, and 14 displayed potent antibacterial activity. Meanwhile, compounds 13 and 14 produced good dose-dependent anti-inflammatory activity against carrageenan-induced paw edema in rats. Keywords: adamantane derivatives, 1,2,4-triazoles, N-Mannich bases, antimicrobial activity, anti-inflammatory activity

  5. Usability Issues in Content Based Multimedia Computer Based Trainings

    OpenAIRE

    Khan, Muhammad Qasim; Rehman, Zia ur

    2009-01-01

    In distance education, students and teachers are at different places and interact with each other with the help of different technologies. Broadcast television, two-way video conferencing, asynchronous learning mode, virtual learning environment (VLE) and content based multimedia computer based trainings (CB-MCBTs) are some of the technologies used to provide distance education. Content Based Multimedia Computer Based Trainings (CB-MCBT) is a computerized learning environment. The acceptance ...

  6. Computer-based multi-channel analyzer based on internet

    International Nuclear Information System (INIS)

    Combined the technology of Internet with computer-based multi-channel analyzer, a new kind of computer-based multi-channel analyzer system which is based on browser is presented. Its framework and principle as well as its implementation are discussed

  7. Risk-based configuration control

    International Nuclear Information System (INIS)

    The presentation discusses the following issues: The Configuration Control; The Risk-based Configuration Control (during power operation mode, and during shutdown mode). PSA requirements. Use of Risk-based Configuration Control System. Configuration Management (basic elements, benefits, information requirements)

  8. Mixture Based Outlier Filtration

    Directory of Open Access Journals (Sweden)

    P. Pecherková

    2006-01-01

    Full Text Available Success/failure of adaptive control algorithms – especially those designed using the Linear Quadratic Gaussian criterion – depends on the quality of the process data used for model identification. One of the most harmful types of process data corruptions are outliers, i.e. ‘wrong data’ lying far away from the range of real data. The presence of outliers in the data negatively affects an estimation of the dynamics of the system. This effect is magnified when the outliers are grouped into blocks. In this paper, we propose an algorithm for outlier detection and removal. It is based on modelling the corrupted data by a two-component probabilistic mixture. The first component of the mixture models uncorrupted process data, while the second models outliers. When the outlier component is detected to be active, a prediction from the uncorrupted data component is computed and used as a reconstruction of the observed data. The resulting reconstruction filter is compared to standard methods on simulated and real data. The filter exhibits excellent properties, especially in the case of blocks of outliers. 

  9. Alphavirus-Based Vaccines

    Directory of Open Access Journals (Sweden)

    Kenneth Lundstrom

    2014-06-01

    Full Text Available Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development. The most commonly used delivery vectors are based on three single-stranded encapsulated alphaviruses, namely Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus. Alphavirus vectors have been applied as replication-deficient recombinant viral particles and, more recently, as replication-proficient particles. Moreover, in vitro transcribed RNA, as well as layered DNA vectors have been applied for immunization. A large number of highly immunogenic viral structural proteins expressed from alphavirus vectors have elicited strong neutralizing antibody responses in multispecies animal models. Furthermore, immunization studies have demonstrated robust protection against challenges with lethal doses of virus in rodents and primates. Similarly, vaccination with alphavirus vectors expressing tumor antigens resulted in prophylactic protection against challenges with tumor-inducing cancerous cells. As certain alphaviruses, such as Chikungunya virus, have been associated with epidemics in animals and humans, attention has also been paid to the development of vaccines against alphaviruses themselves. Recent progress in alphavirus vector development and vaccine technology has allowed conducting clinical trials in humans.

  10. Scintillator based beta batteries

    Science.gov (United States)

    Rensing, Noa M.; Tiernan, Timothy C.; Shirwadkar, Urmila; O'Dougherty, Patrick; Freed, Sara; Hawrami, Rastgo; Squillante, Michael R.

    2013-05-01

    Some long-term, remote applications do not have access to conventional harvestable energy in the form of solar radiation (or other ambient light), wind, environmental vibration, or wave motion. Radiation Monitoring Devices, Inc. (RMD) is carrying out research to address the most challenging applications that need power for many months or years and which have undependable or no access to environmental energy. Radioisotopes are an attractive candidate for this energy source, as they can offer a very high energy density combined with a long lifetime. Both large scale nuclear power plants and radiothermal generators are based on converting nuclear energy to heat, but do not scale well to small sizes. Furthermore, thermo-mechanical power plants depend on moving parts, and RTG's suffer from low efficiency. To address the need for compact nuclear power devices, RMD is developing a novel beta battery, in which the beta emissions from a radioisotope are converted to visible light in a scintillator and then the visible light is converted to electrical power in a photodiode. By incorporating 90Sr into the scintillator SrI2 and coupling the material to a wavelength-matched solar cell, we will create a scalable, compact power source capable of supplying milliwatts to several watts of power over a period of up to 30 years. We will present the latest results of radiation damage studies and materials processing development efforts, and discuss how these factors interact to set the operating life and energy density of the device.

  11. RF Based Spy

    Directory of Open Access Journals (Sweden)

    Robot Prerna Jain

    2014-04-01

    Full Text Available The intention of this paper is to reduce human victims in terrorist attack such as 26/11. So this problem can be overcome by designing the RF based spy robot which involves wireless camera. so that from this we can examine rivals when it required. This robot can quietly enter into enemy area and sends us the information via wireless camera. On the other hand one more feature is added in this robot that is colour sensor. Colour sensor senses the colour of surface and according to that robot will change its colour. Because of this feature this robot can’t easily detected by enemies. The movement of this robot is wirelessly controlled by a hand held RF transmitter to send commands to the RF receiver mounted on the moving robot. Since human life is always Valueable, these robots are the substitution of soldiers in war areas. This spy robot can also be used in star hotels, shopping malls, jewelry show rooms, etc where there can be threat from intruders or terrorists.

  12. Explanation-Based Auditing

    CERN Document Server

    Fabbri, Daniel

    2011-01-01

    To comply with emerging privacy laws and regulations, it has become common for applications like electronic health records systems (EHRs) to collect access logs, which record each time a user (e.g., a hospital employee) accesses a piece of sensitive data (e.g., a patient record). Using the access log, it is easy to answer simple queries (e.g., Who accessed Alice's medical record?), but this often does not provide enough information. In addition to learning who accessed their medical records, patients will likely want to understand why each access occurred. In this paper, we introduce the problem of generating explanations for individual records in an access log. The problem is motivated by user-centric auditing applications, and it also provides a novel approach to misuse detection. We develop a framework for modeling explanations which is based on a fundamental observation: For certain classes of databases, including EHRs, the reason for most data accesses can be inferred from data stored elsewhere in the da...

  13. Geovisualization based upon KML

    Directory of Open Access Journals (Sweden)

    Marianna Zichar

    2012-06-01

    Full Text Available The extension kml refers to a human readable file format that is based on a markup language deriving from XML and became rather popular mainly due to Google Earth. This type of files uses not only the classical geometric data, but coordinates of longitude and latitude (in case of 3D system also coordinate of altitude to visualize the different geographically referenced objects, phenomena and processes. Nowadays more than 10 millions of kml files can be accessed via the internet, and this number is still increasing. However, knowledge of the standard features of kml is not always sufficient, because the circumstances of its application influence its usage. The functionality of the APIs for the web-embeddable Google Maps and Google Earth programs is determinative concerning this issue. The elements of the standard KML cannot be always used without any change, but the clever usage of the API can result effective tools of dynamism. My aim is to review how wide the range of kml files application is, to describe their differences and to share some personal experiences.

  14. ‘"Education-based Research"

    DEFF Research Database (Denmark)

    Degn Johansson, Troels

    This paper lays out a concept of education-based research-the production of research knowledge within the framework of tertiary design education-as an integration of problem-based learning and research-based education. This leads to a critique of reflective practice as the primary way to facilitate...... learning at this level, a discussion of the nature of design problems in the instrumentalist tradition, and some suggestions as to how design studies curricula may facilitate education-based research....

  15. Organizational Semantic Web based Portals

    OpenAIRE

    necula, sabina-cristiana

    2011-01-01

    This paper tries to treat organizational semantic web based portals. The first part of the paper focuses on concepts regarding semantic web based portals. After discussing some concepts we treat the basic functionalities that a semantic web based portal must have and we finish by presenting these functionalities by actual examples. We present semantic web based portals after studying the necessary implementations from literature and practice. We develop some examples that use semantic web bas...

  16. The Activity-Based Approach

    OpenAIRE

    McNally, Michael G.; Rindt, Craig

    2008-01-01

    What is the activity-based approach (ABA) and how does it differ from the conventional trip-based model of travel behavior? From where has the activity approach evolved, what is its current status, and what are its potential applications in transportation forecasting and policy analysis. What have been the contributions of activity-based approaches to understanding travel behavior? The conventional trip-based model of travel demand forecasting (see Chapters 2 and 3) has always lacked...

  17. Securing web-based exams

    NARCIS (Netherlands)

    Sessink, O.D.T.; Beeftink, H.H.; Tramper, J.; Hartog, R.J.M.

    2004-01-01

    Learning management systems may offer web-based exam facilities. Such facilities entail a higher risk to exams fraud than traditional paper-based exams. The article discusses security issues with web-based exams, and proposes precautionary measures to reduce the risks. A security model is presented

  18. PMIS: Data Base Design Report

    Science.gov (United States)

    Fiddleman, Richard; Gorman, Michael M.

    1972-01-01

    PMIS is a computer-based planning and management information system for local school districts. This report centers on the PMIS data bases that contain school system data by reviewing the major phases involved in their creation, explaining the factors that caused the unique orientation of the data bases, reviewing the two tasks that comprise the…

  19. Image Data Bases on Campus.

    Science.gov (United States)

    Kaplan, Reid; Mathieson, Gordon

    1989-01-01

    A description of how image database technology was used to develop two prototypes for academic and administrative applications at Yale University, one using a video data base integration and the other using document-scanning data base technology, is presented. Technical underpinnings for the creation of data bases are described. (Author/MLW)

  20. Lunar Base Heat Pump

    Science.gov (United States)

    Walker, D.; Fischbach, D.; Tetreault, R.

    1996-01-01

    The objective of this project was to investigate the feasibility of constructing a heat pump suitable for use as a heat rejection device in applications such as a lunar base. In this situation, direct heat rejection through the use of radiators is not possible at a temperature suitable for lde support systems. Initial analysis of a heat pump of this type called for a temperature lift of approximately 378 deg. K, which is considerably higher than is commonly called for in HVAC and refrigeration applications where heat pumps are most often employed. Also because of the variation of the rejection temperature (from 100 to 381 deg. K), extreme flexibility in the configuration and operation of the heat pump is required. A three-stage compression cycle using a refrigerant such as CFC-11 or HCFC-123 was formulated with operation possible with one, two or three stages of compression. Also, to meet the redundancy requirements, compression was divided up over multiple compressors in each stage. A control scheme was devised that allowed these multiple compressors to be operated as required so that the heat pump could perform with variable heat loads and rejection conditions. A prototype heat pump was designed and constructed to investigate the key elements of the high-lift heat pump concept. Control software was written and implemented in the prototype to allow fully automatic operation. The heat pump was capable of operation over a wide range of rejection temperatures and cooling loads, while maintaining cooling water temperature well within the required specification of 40 deg. C +/- 1.7 deg. C. This performance was verified through testing.

  1. Telemetry-Based Ranging

    Science.gov (United States)

    Hamkins, Jon; Vilnrotter, Victor A.; Andrews, Kenneth S.; Shambayati, Shervin

    2011-01-01

    A telemetry-based ranging scheme was developed in which the downlink ranging signal is eliminated, and the range is computed directly from the downlink telemetry signal. This is the first Deep Space Network (DSN) ranging technology that does not require the spacecraft to transmit a separate ranging signal. By contrast, the evolutionary ranging techniques used over the years by NASA missions, including sequential ranging (transmission of a sequence of sinusoids) and PN-ranging (transmission of a pseudo-noise sequence) whether regenerative (spacecraft acquires, then regenerates and retransmits a noise-free ranging signal) or transparent (spacecraft feeds the noisy demodulated uplink ranging signal into the downlink phase modulator) relied on spacecraft power and bandwidth to transmit an explicit ranging signal. The state of the art in ranging is described in an emerging CCSDS (Consultative Committee for Space Data Systems) standard, in which a pseudo-noise (PN) sequence is transmitted from the ground to the spacecraft, acquired onboard, and the PN sequence is coherently retransmitted back to the ground, where a delay measurement is made between the uplink and downlink signals. In this work, the telemetry signal is aligned with the uplink PN code epoch. The ground station computes the delay between the uplink signal transmission and the received downlink telemetry. Such a computation is feasible because symbol synchronizability is already an integral part of the telemetry design. Under existing technology, the telemetry signal cannot be used for ranging because its arrival-time information is not coherent with any Earth reference signal. By introducing this coherence, and performing joint telemetry detection and arrival-time estimation on the ground, a high-rate telemetry signal can provide all the precision necessary for spacecraft ranging.

  2. Space-based detectors

    Science.gov (United States)

    Sesana, A.; Weber, W. J.; Killow, C. J.; Perreur-Lloyd, M.; Robertson, D. I.; Ward, H.; Fitzsimons, E. D.; Bryant, J.; Cruise, A. M.; Dixon, G.; Hoyland, D.; Smith, D.; Bogenstahl, J.; McNamara, P. W.; Gerndt, R.; Flatscher, R.; Hechenblaikner, G.; Hewitson, M.; Gerberding, O.; Barke, S.; Brause, N.; Bykov, I.; Danzmann, K.; Enggaard, A.; Gianolio, A.; Vendt Hansen, T.; Heinzel, G.; Hornstrup, A.; Jennrich, O.; Kullmann, J.; Møller-Pedersen, S.; Rasmussen, T.; Reiche, J.; Sodnik, Z.; Suess, M.; Armano, M.; Sumner, T.; Bender, P. L.; Akutsu, T.; Sathyaprakash, B. S.

    2014-12-01

    The parallel session C5 on Space-Based Detectors gave a broad overview over the planned space missions related to gravitational wave detection. Overviews of the revolutionary science to be expected from LISA was given by Alberto Sesana and Sasha Buchman. The launch of LISA Pathfinder (LPF) is planned for 2015. This mission and its payload "LISA Technology Package" will demonstrate key technologies for LISA. In this context, reference masses in free fall for LISA, and gravitational physics in general, was described by William Weber, laser interferometry at the pico-metre level and the optical bench of LPF was presented by Christian Killow and the performance of the LPF optical metrology system by Paul McNamara. While LPF will not yet be sensitive to gravitational waves, it may nevertheless be used to explore fundamental physics questions, which was discussed by Michele Armano. Some parts of the LISA technology that are not going to be demonstrated by LPF, but under intensive development at the moment, were presented by Oliver Jennrich and Oliver Gerberding. Looking into the future, Japan is studying the design of a mid-frequency detector called DECIGO, which was discussed by Tomotada Akutsu. Using atom interferometry for gravitational wave detection has also been recently proposed, and it was critically reviewed by Peter Bender. In the nearer future, the launch of GRACE Follow-On (for Earth gravity observation) is scheduled for 2017, and it will include a Laser Ranging Interferometer as technology demonstrator. This will be the first inter-spacecraft laser interferometer and has many aspects in common with the LISA long arm, as discussed by Andrew Sutton.

  3. Soy-based renoprotection.

    Science.gov (United States)

    McGraw, Nancy J; Krul, Elaine S; Grunz-Borgmann, Elizabeth; Parrish, Alan R

    2016-05-01

    Chronic kidney disease (CKD) is a significant public health problem as risk factors such as advanced age, obesity, hypertension and diabetes rise in the global population. Currently there are no effective pharmacologic treatments for this disease. The role of diet is important for slowing the progression of CKD and managing symptoms in later stages of renal insufficiency. While low protein diets are generally recommended, maintaining adequate levels of intake is critical for health. There is an increasing appreciation that the source of protein may also be important. Soybean protein has been the most extensively studied plant-based protein in subjects with kidney disease and has demonstrated renal protective properties in a number of clinical studies. Soy protein consumption has been shown to slow the decline in estimated glomerular filtration rate and significantly improve proteinuria in diabetic and non-diabetic patients with nephropathy. Soy's beneficial effects on renal function may also result from its impact on certain physiological risk factors for CKD such as dyslipidemia, hypertension and hyperglycemia. Soy intake is also associated with improvements in antioxidant status and systemic inflammation in early and late stage CKD patients. Studies conducted in animal models have helped to identify the underlying molecular mechanisms that may play a role in the positive effects of soy protein on renal parameters in polycystic kidney disease, metabolically-induced kidney dysfunction and age-associated progressive nephropathy. Despite the established relationship between soy and renoprotection, further studies are needed for a clear understanding of the role of the cellular and molecular target(s) of soy protein in maintaining renal function. PMID:27152261

  4. Nanoparticle-based Sensors

    Directory of Open Access Journals (Sweden)

    V.K. Khanna

    2008-09-01

    Full Text Available Nanoparticles exhibit several unique properties that can be applied to develop chemical and biosensorspossessing desirable features like enhanced sensitivity and lower detection limits. Gold nanoparticles arecoated with sugars tailored to recognise different biological substances. When mixed with a weak solution ofthe sugar-coated nanoparticles, the target substance, e.g., ricin or E.coli, attaches to the sugar, thereby alteringits properties and changing the colour. Spores of bacterium labeled with carbon dots have been found to glowupon illumination when viewed with a confocal microscope. Enzyme/nanoparticle-based optical sensors forthe detection of organophosphate (OP compounds employ nanoparticle-modified fluorescence of an inhibitorof the enzyme to generate the signal for the OP compound detection. Nanoparticles shaped as nanoprisms,built of silver atoms, appear red on exposure to light. These nanoparticles are used as diagnostic labels thatglow when target DNA, e.g., those of anthrax or HIV, are present. Of great importance are tools like goldnanoparticle-enhanced surface-plasmon resonance sensor and silver nanoparticle surface-enhanced portableRaman integrated tunable sensor. Nanoparticle metal oxide chemiresistors using micro electro mechanical systemhotplate are very promising devices for toxic gas sensing. Chemiresistors comprising thin films of nanogoldparticles, encapsulated in monomolecular layers of functionalised alkanethiols, deposited on interdigitatedmicroelectrodes, show resistance changes through reversible absorption of vapours of harmful gases. Thispaper reviews the state-of-the-art sensors for chemical and biological terror agents, indicates their capabilitiesand applications, and presents the future scope of these devices.Defence Science Journal, 2008, 58(5, pp.608-616, DOI:http://dx.doi.org/10.14429/dsj.58.1683

  5. Barrier Data Base user's guide

    International Nuclear Information System (INIS)

    A special purpose data base for physical security barriers has been developed. In addition to barriers, the entities accommodated by the Barrier Data Base (BDB) include threats and references. A threat is established as a configuration of people and equipment which has been employed to penetrate (or attempt to penetrate) a barrier. References are used to cite publications pertinent to the barriers and threats in the data base. Utilization and maintenance of the Barrier Data Base is achieved with LIST, QUERY, ENTER, DELETE, and CHANGE commands which are used to manipulate the data base entities

  6. From oil-based mud to water-based mud

    International Nuclear Information System (INIS)

    Maersk Olie og Gas AS has used low toxic oil-based muds extensively since 1982 for drilling development wells and later in the development of horizontal well drilling techniques. However, in view of the strong drive towards a reduction in the amount of oil discharged to the North Sea from the oil industry, Maersk Olie og Gas AS initiated trials with new or improved types of water-based mud, first in deviated wells (1989) and then in horizontal wells (1990). The paper reviews Maersk Olie og Gas As experience with oil-based mud since the drilling of the first horizontal well in 1987, specifically with respect to cuttings washing equipment, oil retention on cuttings, and the procedure for monitoring of this parameter. It describes the circumstances leading to the decision to revert to water-based mud systems. Finally, it reviews the experience gained so far with the new improved types of water-based mud systems, mainly glycol and KCl/polymer mud systems. Comparison of operational data, such as rate of penetration, torque and drag, etc., is made between wells drilled with oil-based mud and water-based mud. The trials with the new improved types of water-based mud systems have been positive, i.e. horizontal wells can be drilled successfully with water-based mud. As a result, Maersk Olie og and Gas AS has decided to discontinue the use of low toxic oil-based muds in the Danish sector of the North Sea

  7. Workplace Based Assessment in Psychiatry

    Directory of Open Access Journals (Sweden)

    Ayse Devrim Basterzi

    2009-11-01

    Full Text Available Workplace based assessment refers to the assessment of working practices based on what doctors actually do in the workplace, and is predominantly carried out in the workplace itself. Assessment drives learning and it is therefore essential that workplace-based assessment focuses on important attributes rather than what is easiest to assess. Workplacebased assessment is usually competency based. Workplace based assesments may well facilitate and enhance various aspects of educational supervisions, including its structure, frequency and duration etc. The structure and content of workplace based assesments should be monitored to ensure that its benefits are maximised by remaining tailored to individual trainees' needs. Workplace based assesment should be used for formative and summative assessments. Several formative assessment methods have been developed for use in the workplace such as mini clinical evaluation exercise (mini-cex, evidence based journal club assesment and case based discussion, multi source feedback etc. This review discusses the need of workplace based assesments in psychiatry graduate education and introduces some of the work place based assesment methods.

  8. Measurement-based quantum communication

    Science.gov (United States)

    Zwerger, M.; Briegel, H. J.; Dür, W.

    2016-03-01

    We review and discuss the potential of using measurement-based elements in quantum communication schemes, where certain tasks are realized with the help of entangled resource states that are processed by measurements. We consider long-range quantum communication based on the transmission of encoded quantum states, where encoding, decoding and syndrome readout are implemented using small-scale resource states. We also discuss entanglement-based schemes and consider measurement-based quantum repeaters. An important element in these schemes is entanglement purification, which can also be implemented in a measurement-based way. We analyze the influence of noise and imperfections in these schemes and show that measurement-based implementation allows for very large error thresholds of the order of 10 % noise per qubit and more. We show how to obtain optimal resource states for different tasks and discuss first experimental realizations of measurement-based quantum error correction using trapped ions and photons.

  9. Case-based reasoning: The marriage of knowledge base and data base

    Science.gov (United States)

    Pulaski, Kirt; Casadaban, Cyprian

    1988-01-01

    The coupling of data and knowledge has a synergistic effect when building an intelligent data base. The goal is to integrate the data and knowledge almost to the point of indistinguishability, permitting them to be used interchangeably. Examples given in this paper suggest that Case-Based Reasoning is a more integrated way to link data and knowledge than pure rule-based reasoning.

  10. Evidence-based dentistry.

    Science.gov (United States)

    Chambers, David W

    2010-01-01

    Both panegyric and criticism of evidence-based dentistry tend to be clumsy because the concept is poorly defined. This analysis identifies several contributions to the profession that have been made under the EBD banner. Although the concept of clinicians integrating clinical epidemiology, the wisdom of their practices, and patients' values is powerful, its implementation has been distorted by a too heavy emphasis of computerized searches for research findings that meet the standards of academics. Although EBD advocates enjoy sharing anecdotal accounts of mistakes others have made, faulting others is not proof that one's own position is correct. There is no systematic, high-quality evidence that EBD is effective. The metaphor of a three-legged stool (evidence, experience, values, and integration) is used as an organizing principle. "Best evidence" has become a preoccupation among EBD enthusiasts. That overlong but thinly developed leg of the stool is critiqued from the perspectives of the criteria for evidence, the difference between internal and external validity, the relationship between evidence and decision making, the ambiguous meaning of "best," and the role of reasonable doubt. The strongest leg of the stool is clinical experience. Although bias exists in all observations (including searches for evidence), there are simple procedures that can be employed in practice to increase useful and objective evidence there, and there are dangers in delegating policy regarding allowable treatments to external groups. Patient and practitioner values are the shortest leg of the stool. As they are so little recognized, their integration in EBD is problematic and ethical tensions exist where paternalism privileges science over patient's self-determined best interests. Four potential approaches to integration are suggested, recognizing that there is virtually no literature on how the "seat" of the three-legged stool works or should work. It is likely that most dentists

  11. Optimal pricing decision model based on activity-based costing

    Institute of Scientific and Technical Information of China (English)

    王福胜; 常庆芳

    2003-01-01

    In order to find out the applicability of the optimal pricing decision model based on conventional costbehavior model after activity-based costing has given strong shock to the conventional cost behavior model andits assumptions, detailed analyses have been made using the activity-based cost behavior and cost-volume-profitanalysis model, and it is concluded from these analyses that the theory behind the construction of optimal pri-cing decision model is still tenable under activity-based costing, but the conventional optimal pricing decisionmodel must be modified as appropriate to the activity-based costing based cost behavior model and cost-volume-profit analysis model, and an optimal pricing decision model is really a product pricing decision model construc-ted by following the economic principle of maximizing profit.

  12. Knowledge base verification based on enhanced colored petri net

    International Nuclear Information System (INIS)

    Verification is a process aimed at demonstrating whether a system meets it's specified requirements. As expert systems are used in various applications, the knowledge base verification of systems takes an importatn position. The conventional Petri net approach that has been studied recently in order to verify the knowledge base is found that it is inadequate to verify the knowledge base of large and complex system, such as alarm processing system of nuclear power plant. Thus, we propose an improved method that models the knowledge base as enhanced colored Petri net. In this study, we analyze the reachability and the error characteristics of the knowledge base and apply the method to verification of simple knowledge base

  13. Knowledge base verification based on enhanced colored petri net

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Hyun; Seong, Poong Hyun [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1997-12-31

    Verification is a process aimed at demonstrating whether a system meets it`s specified requirements. As expert systems are used in various applications, the knowledge base verification of systems takes an important position. The conventional Petri net approach that has been studied recently in order to verify the knowledge base is found that it is inadequate to verify the knowledge base of large and complex system, such as alarm processing system of nuclear power plant. Thus, we propose an improved method that models the knowledge base as enhanced colored Petri net. In this study, we analyze the reachability and the error characteristics of the knowledge base and apply the method to verification of simple knowledge base. 8 refs., 4 figs. (Author)

  14. ANALYSIS-BASED SPARSE RECONSTRUCTION WITH SYNTHESIS-BASED SOLVERS

    OpenAIRE

    Cleju, Nicolae; Jafari, Maria,; Plumbley, Mark D.

    2012-01-01

    Analysis based reconstruction has recently been introduced as an alternative to the well-known synthesis sparsity model used in a variety of signal processing areas. In this paper we convert the analysis exact-sparse reconstruction problem to an equivalent synthesis recovery problem with a set of additional constraints. We are therefore able to use existing synthesis-based algorithms for analysis-based exact-sparse recovery. We call this the Analysis-By-Synthesis (ABS) approach. We evaluate o...

  15. XML-Based SHINE Knowledge Base Interchange Language

    Science.gov (United States)

    James, Mark; Mackey, Ryan; Tikidjian, Raffi

    2008-01-01

    The SHINE Knowledge Base Interchange Language software has been designed to more efficiently send new knowledge bases to spacecraft that have been embedded with the Spacecraft Health Inference Engine (SHINE) tool. The intention of the behavioral model is to capture most of the information generally associated with a spacecraft functional model, while specifically addressing the needs of execution within SHINE and Livingstone. As such, it has some constructs that are based on one or the other.

  16. Graph Cuts based Image Segmentation using Fuzzy Rule Based System

    OpenAIRE

    Khokher, M. R.; A. Ghafoor; A.M. Siddiqui

    2012-01-01

    This work deals with the segmentation of gray scale, color and texture images using graph cuts. From input image, a graph is constructed using intensity, color and texture profiles of the image simultaneously. Based on the nature of image, a fuzzy rule based system is designed to find the weight that should be given to a specific image feature during graph development. The graph obtained from the fuzzy rule based weighted average of different image features is further used in normalized graph...

  17. Location-based Modeling and Analysis: Tropos-based Approach

    OpenAIRE

    Ali, Raian; Dalpiaz, Fabiano; Giorgini, Paolo

    2008-01-01

    The continuous growth of interest in mobile applications makes the concept of location essential to design and develop software systems. Location-based software is supposed to be able to monitor the location and choose accordingly the most appropriate behavior. In this paper, we propose a novel conceptual framework to model and analyze location-based software. We mainly focus on the social facets of locations adopting concepts such as social actor, resource, and location-based behavior. Our a...

  18. Acids and bases solvent effects on acid-base strenght

    CERN Document Server

    Cox, Brian G

    2013-01-01

    Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter- ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented.

  19. Remote Monitoring System for Communication Base Based on Short Message

    Directory of Open Access Journals (Sweden)

    Han Yu Fu

    2013-07-01

    Full Text Available This paper presents design and development of an automatic monitoring system of communication base which is an important means to realize modernization of mobile communication base station management. Firstly, this paper proposes the architecture of the monitoring system. The proposed system consists of mocrocontrollers, sensors, GSM module and MFRC500 etc. The value of parameters is measured in the system including terminal is studied and designed, including hardware design based on embedded system and software design. Finally, communication module is discussed. The monitoring system which is designed  based on GSM SMS(short message service can improve the integrity, reliability, flexibility and intellectuality of monitoring system.

  20. Computer-based and web-based radiation safety training

    Energy Technology Data Exchange (ETDEWEB)

    Owen, C., LLNL

    1998-03-01

    The traditional approach to delivering radiation safety training has been to provide a stand-up lecture of the topic, with the possible aid of video, and to repeat the same material periodically. New approaches to meeting training requirements are needed to address the advent of flexible work hours and telecommuting, and to better accommodate individuals learning at their own pace. Computer- based and web-based radiation safety training can provide this alternative. Computer-based and web- based training is an interactive form of learning that the student controls, resulting in enhanced and focused learning at a time most often chosen by the student.

  1. Concurrent array-based queue

    Energy Technology Data Exchange (ETDEWEB)

    Heidelberger, Philip; Steinmacher-Burow, Burkhard

    2015-01-06

    According to one embodiment, a method for implementing an array-based queue in memory of a memory system that includes a controller includes configuring, in the memory, metadata of the array-based queue. The configuring comprises defining, in metadata, an array start location in the memory for the array-based queue, defining, in the metadata, an array size for the array-based queue, defining, in the metadata, a queue top for the array-based queue and defining, in the metadata, a queue bottom for the array-based queue. The method also includes the controller serving a request for an operation on the queue, the request providing the location in the memory of the metadata of the queue.

  2. Fast Density Based Clustering Algorithm

    OpenAIRE

    Priyanka Trikha; Singh Vijendra

    2013-01-01

    Clustering problem is an unsupervised learning problem. It is a procedure that partition data objects into matching clusters. The data objects in the same cluster are quite similar to each other and dissimilar in the other clusters. The traditional algorithms do not meet the latest multiple requirements simultaneously for objects. Density-based clustering algorithms find clusters based on density of data points in a region. DBSCAN algorithm is one of the density-based clustering algorithms. I...

  3. Restructuring and simplifying rule bases

    OpenAIRE

    Vanthienen, Jan; Dries, E; WETS, G

    1995-01-01

    Rule bases are commonly acquired, by expert and/or knowledge engineer, in a form which is well suited for acquisition purposes. When the knowledge base is executed, however, a different structure may be required. Moreover, since human experts normally do not provide the knowledge in compact chunks, rule bases often suffer from redundancy. This may considerably harm efficiency. In this paper a procedure is examined to transform rules that are specified in the knowledge acquisition process ...

  4. Principles of models based engineering

    Energy Technology Data Exchange (ETDEWEB)

    Dolin, R.M.; Hefele, J.

    1996-11-01

    This report describes a Models Based Engineering (MBE) philosophy and implementation strategy that has been developed at Los Alamos National Laboratory`s Center for Advanced Engineering Technology. A major theme in this discussion is that models based engineering is an information management technology enabling the development of information driven engineering. Unlike other information management technologies, models based engineering encompasses the breadth of engineering information, from design intent through product definition to consumer application.

  5. Risk-based configuration management

    International Nuclear Information System (INIS)

    Risk-based configuration management is an important research area of using PSA technology to evaluate and improve the Technical Specification Requirements of nuclear power plant. Some aspects on risk-based configuration management are discussed, including evaluation methods, risk acceptance criteria and essential elements which should be paid attention to during the management process. And results of the case study based on a real nuclear power plant are presented

  6. dBASE IV basics

    Energy Technology Data Exchange (ETDEWEB)

    O`Connor, P.

    1994-09-01

    This is a user`s manual for dBASE IV. dBASE IV is a popular software application that can be used on your personal computer to help organize and maintain your database files. It is actually a set of tools with which you can create, organize, select and manipulate data in a simple yet effective manner. dBASE IV offers three methods of working with the product: (1) control center: (2) command line; and (3) programming.

  7. Instantaneous noise-based logic

    OpenAIRE

    Kish, Laszlo B.; Khatri, Sunil; Peper, Ferdinand

    2010-01-01

    We show two universal, Boolean, deterministic logic schemes based on binary noise timefunctions that can be realized without time-averaging units. The first scheme is based on a new bipolar random telegraph wave scheme and the second one makes use of the recent noise-based logic which is conjectured to be the brain's method of logic operations [Physics Letters A 373 (2009) 2338-2342]. Error propagation and error removal issues are also addressed.

  8. Feature-Based Attention and Feature-Based Expectation.

    Science.gov (United States)

    Summerfield, Christopher; Egner, Tobias

    2016-06-01

    Foreknowledge of target stimulus features improves visual search performance as a result of 'feature-based attention' (FBA). Recent studies have reported that 'feature-based expectation' (FBE) also heightens decision sensitivity. Superficially, it appears that the latter work has simply rediscovered (and relabeled) the effects of FBA. However, this is not the case. Here we explain why. PMID:27079632

  9. Trace-Based Code Generation for Model-Based Testing

    NARCIS (Netherlands)

    Kanstrén, T.; Piel, E.; Gross, H.-G.

    2009-01-01

    Paper Submitted for review at the Eighth International Conference on Generative Programming and Component Engineering. Model-based testing can be a powerful means to generate test cases for the system under test. However, creating a useful model for model-based testing requires expertise in the (fo

  10. Managing the Gap between Curriculum Based and Problem Based Learning

    DEFF Research Database (Denmark)

    Bygholm, Ann; Buus, Lillian

    2009-01-01

    /or but rather both/and. In this paper we describe an approach to design and delivery of online courses in computer science which on the one hand is based on a specified curriculum and on the other hand gives room for different learning strategies, problem based learning being one of them. We discuss...

  11. Isochronous cyclotron data base description

    International Nuclear Information System (INIS)

    The relational data base of the control parameters of the isochronous cyclotron, Isochronous Cyclotron Data Base (ICDB), is described. The relational data base under consideration, written in Transact SQL for the MS SQL Server 2000 with the use of MS Enterprise Manager and MS Query Analyzer, was installed on the server of the AIC144 isochronous cyclotron in Krakow, which operates under the control of the operating system MS Windows Server 2003 (Standard Edition). The interface of the data base under considerations is written in C++ with the use of Visual C++ .NET and is built in the Cyclotron Operator Help Program (COHP), which is used for modeling the operational modes of the isochronous cyclotron. Communication between the COHP and the relational data base is realised on the base of the Open Data Base Connectivity protocol. The relational data base of the control parameter of the isochronous cyclotron is intended: firstly, for systematization and automatic use of all measured and modelled magnetic field maps in the process of modeling the operational modes; secondly, for systematization and convenient access to the stored operational modes; thirdly, for simplifying the operator's work. The relational data base of the control parameter of the isochronous cyclotron reflects its physical structure and the logic of its operator's work. (author)

  12. Distributed event-based systems

    CERN Document Server

    Fiege, Ludger; Pietzuch, Peter R

    2006-01-01

    This book provides an in-depth description of event-based systems, covering topics ranging from local event matching and distributed event forwarding algorithms, through a practical discussion of software engineering issues raised by the event-based style, to state-of-the-art research in event-based systems like composite event detection and security. The authors offer a comprehensive overview, and show the power of event-based architectures in modern system design, encouraging professionals to exploit this technique in next generation large-scale distributed applications like information diss

  13. Web-based support systems

    CERN Document Server

    Yao, JingTao

    2010-01-01

    The emerging interdisciplinary study of Web-based support systems focuses on the theories, technologies and tools for the design and implementation of Web-based systems that support various human activities. This book presents the state-of-the-art in Web-based support systems (WSS). The research on WSS is multidisciplinary and focuses on supporting various human activities in different domains/fields based on computer science, information technology, and Web technology. The main goal is to take the opportunities of the Web, to meet the challenges of the Web, to extend the human physical limita

  14. Capability-based computer systems

    CERN Document Server

    Levy, Henry M

    2014-01-01

    Capability-Based Computer Systems focuses on computer programs and their capabilities. The text first elaborates capability- and object-based system concepts, including capability-based systems, object-based approach, and summary. The book then describes early descriptor architectures and explains the Burroughs B5000, Rice University Computer, and Basic Language Machine. The text also focuses on early capability architectures. Dennis and Van Horn's Supervisor; CAL-TSS System; MIT PDP-1 Timesharing System; and Chicago Magic Number Machine are discussed. The book then describes Plessey System 25

  15. Polyurethane Based Inhibition for High Flame Temperature Nitramine Based Composite Modified Double Base propellant

    OpenAIRE

    S. D. Kakade; M. V. Vaidya; D. G. Khangaonkar; P. K. Divekar; U. B. Kadam; S. N. Asthana

    1998-01-01

    The findings for polypropylene glycol (PPG) and hydroxyl-terminated polybutadiene (HTPB)-based inhibition systems are reported. These findings established that the inhibition system comprising HTPB-IPDI-IDP binder and Sb/sub 2/O/sub 3/-C black filler is most suitable for advanced nitramine-based composite modified double-base propellants in terms of mechanical properties and processibility. The promising composition was characterised for glass-transition behaviour and propellant-inhibi...

  16. Wavelength conversion based spectral imaging

    DEFF Research Database (Denmark)

    Dam, Jeppe Seidelin

    resolution for this spectral region. Today, an increasing number of applications exists outside the spectral region covered by Si-based devices, e.g. within cleantech, medical or food imaging. We present a technology based on wavelength conversion which will extend the spectral coverage of state of the art...

  17. Interpretation-Based Grammar Teaching.

    Science.gov (United States)

    Ellis, Rod

    1993-01-01

    In contrast to the usual approach to teaching grammar, this article argues for a comprehension-based approach. Based on a model of second-language acquisition, it examines a number of possible goals for grammar instruction (e.g., to promote "intake" of new grammatical features by helping learners notice input features and comprehend the meaning).…

  18. Methods in Logic Based Control

    DEFF Research Database (Denmark)

    Christensen, Georg Kronborg

    1999-01-01

    Desing and theory of Logic Based Control systems.Boolean Algebra, Karnaugh Map, Quine McClusky's algorithm. Sequential control design. Logic Based Control Method, Cascade Control Method. Implementation techniques: relay, pneumatic, TTL/CMOS,PAL and PLC- and Soft_PLC implementation. PLC...

  19. The knowledge base of journalism

    DEFF Research Database (Denmark)

    Svith, Flemming

    theories on practice and knowledge. As the result of an abductive reasoning is a theory proposal, there is a need for more deductive approaches to test the validity of this knowledge base claim. It is thus relevant to investigate which rationales are included in the knowledge base of journalism, as the...

  20. Team-Based Global Organizations

    DEFF Research Database (Denmark)

    Zander, Lena; Butler, Christina Lea; Mockaitis, Audra;

    2015-01-01

    Purpose-We propose team-based organizing as an alternative to more traditional forms of hierarchy-based organizing in global firms. Methodology/approach-Advancements in the study of global teams, leadership, process, and outcomes were organized into four themes: (1) openness toward linguistic and...

  1. FAST WATERSHED-BASED DILATION

    OpenAIRE

    Jakub Smołka

    2014-01-01

    A watershed-based region growing image segmentation algorithm requires a fast watershed-based dilation implementation for effective operation. This paper presents a new way for watershed image representation and uses this representation for effective implementation of dilation. Methods for improving the algorithm speed are discussed. Presented solutions may also be used for solving other problems where fast set summation is required.

  2. Evidence-Based Laboratory Medicine

    Institute of Scientific and Technical Information of China (English)

    Christopher P Price

    2004-01-01

    @@ Whilst there have been several definitions of Evidence-Based Medicine (EBM), the one given by David Sackett is probably the most accurate and well accepted; he stated that "evidence-based medicine is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients"[1].

  3. Theory-Based Stakeholder Evaluation

    Science.gov (United States)

    Hansen, Morten Balle; Vedung, Evert

    2010-01-01

    This article introduces a new approach to program theory evaluation called theory-based stakeholder evaluation or the TSE model for short. Most theory-based approaches are program theory driven and some are stakeholder oriented as well. Practically, all of the latter fuse the program perceptions of the various stakeholder groups into one unitary…

  4. Reliability-Based Code Calibration

    DEFF Research Database (Denmark)

    Faber, M.H.; Sørensen, John Dalsgaard

    2003-01-01

    The present paper addresses fundamental concepts of reliability based code calibration. First basic principles of structural reliability theory are introduced and it is shown how the results of FORM based reliability analysis may be related to partial safety factors and characteristic values...

  5. Plasma-based accelerator structures

    International Nuclear Information System (INIS)

    Plasma-based accelerators have the ability to sustain extremely large accelerating gradients, with possible high-energy physics applications. This dissertation further develops the theory of plasma-based accelerators by addressing three topics: the performance of a hollow plasma channel as an accelerating structure, the generation of ultrashort electron bunches, and the propagation of laser pulses is underdense plasmas

  6. Rapid mixing and Markov bases

    OpenAIRE

    Windisch, Tobias

    2015-01-01

    The mixing behaviour of Markov chains on lattice points of polytopes using Markov bases is examined. It is shown that, in fixed dimension, these Markov chains do not mix rapidly. As a way out, a method of how to adapt Markov bases in order to achieve the fastest mixing behaviour is introduced.

  7. Cloud-Based Data Storage

    Science.gov (United States)

    Waters, John K.

    2011-01-01

    The vulnerability and inefficiency of backing up data on-site is prompting school districts to switch to more secure, less troublesome cloud-based options. District auditors are pushing for a better way to back up their data than the on-site, tape-based system that had been used for years. About three years ago, Hendrick School District in…

  8. GPP-Based Soft Base Station Designing and Optimization

    Institute of Scientific and Technical Information of China (English)

    Xiao-Feng Tao; Yan-Zhao Hou; Kai-Dong Wang; Hai-Yang He; Y.Jay Guo

    2013-01-01

    It is generally acknowledged that mobile communication base stations are composed of hardware components such as Field Programming Gate Array (FPGA),Digital Signal Processor (DSP),which promise reliable and fluent services for the mobile users.However,with the increasing demand for energy-efficiency,approaches of low power-consumption and high-flexibility are needed urgently.In this circumstance,General Purpose Processor (GPP) attracts people's attention for its low-cost and flexibility.Benefited from the development of modern GPP in multi-core,Single Instruction Multiple Data (SIMD) instructions,larger cache,etc.,GPPs are capable of performing high-density digital processing.In this paper,we compare several software-defined radio (SDR) prototypes and propose the general architecture of GPP-based soft base stations.Then,the schematic design of resource allocation and algorithm optimization in soft base station implementation are studied.As an application example,a prototype of GPP-based soft base station referring to the 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) is realized and evaluated.To the best of our knowledge,it is the first Soft-LTE prototype ever reported.In the end,we evaluate the timing performance of the LTE soft base station and a packet loss ratio of less than 0.003 is obtained.

  9. Tag Based Audio Search Engine

    Directory of Open Access Journals (Sweden)

    Parameswaran Vellachu

    2012-03-01

    Full Text Available The volume of the music database is increasing day by day. Getting the required song as per the choice of the listener is a big challenge. Hence, it is really hard to manage this huge quantity, in terms of searching, filtering, through the music database. It is surprising to see that the audio and music industry still rely on very simplistic metadata to describe music files. However, while searching audio resource, an efficient "Tag Based Audio Search Engine" is necessary. The current research focuses on two aspects of the musical databases 1. Tag Based Semantic Annotation Generation using the tag based approach.2. An audio search engine, using which the user can retrieve the songs based on the users choice. The proposed method can be used to annotation and retrieve songs based on musical instruments used , mood of the song, theme of the song, singer, music director, artist, film director, instrument, genre or style and so on.

  10. Lignin-Based Thermoplastic Materials.

    Science.gov (United States)

    Wang, Chao; Kelley, Stephen S; Venditti, Richard A

    2016-04-21

    Lignin-based thermoplastic materials have attracted increasing interest as sustainable, cost-effective, and biodegradable alternatives for petroleum-based thermoplastics. As an amorphous thermoplastic material, lignin has a relatively high glass-transition temperature and also undergoes radical-induced self-condensation at high temperatures, which limits its thermal processability. Additionally, lignin-based materials are usually brittle and exhibit poor mechanical properties. To improve the thermoplasticity and mechanical properties of technical lignin, polymers or plasticizers are usually integrated with lignin by blending or chemical modification. This Review attempts to cover the reported approaches towards the development of lignin-based thermoplastic materials on the basis of published information. Approaches reviewed include plasticization, blending with miscible polymers, and chemical modifications by esterification, etherification, polymer grafting, and copolymerization. Those lignin-based thermoplastic materials are expected to show applications as engineering plastics, polymeric foams, thermoplastic elastomers, and carbon-fiber precursors. PMID:27059111

  11. Power Reactor Embrittlement Data Base

    International Nuclear Information System (INIS)

    Regulatory and research evaluations of embrittlement predication models and of pressure vessel integrity can be greatly expedited by the use of a well-designed, computerized data base. The Power Reactor Embrittlement Data Base (PR-EDB) is such a comprehensive collection of data for US commercial nuclear reactors. The Nuclear Regulatory Commission (NRC) has provided financial support, and the Electric Power Research Institute (EPRI) has provided technical assistance in the quality assurance (QA) of the data to establish an industry-wide data base that will be maintained and updated on a long-term basis. Successful applications of the data base to several of NRC's evaluations have received favorable response and support for its continuation. The future direction of the data base has been designed to include the test reactor and other types of data of interest to the regulators and the researchers. 1 ref

  12. Content-Based Image Retrial Based on Hadoop

    Directory of Open Access Journals (Sweden)

    DongSheng Yin

    2013-01-01

    Full Text Available Generally, time complexity of algorithms for content-based image retrial is extremely high. In order to retrieve images on large-scale databases efficiently, a new way for retrieving based on Hadoop distributed framework is proposed. Firstly, a database of images features is built by using Speeded Up Robust Features algorithm and Locality-Sensitive Hashing and then perform the search on Hadoop platform in a parallel way specially designed. Considerable experimental results show that it is able to retrieve images based on content on large-scale cluster and image sets effectively.

  13. Survey paper on Sketch Based and Content Based Image Retrieval

    OpenAIRE

    Gaidhani, Prachi A.; S. B. Bagal

    2015-01-01

    This survey paper presents an overview of development of Sketch Based Image Retrieval (SBIR) and Content based image retrieval (CBIR) in the past few years. There is awful growth in bulk of images as well as the far-flung application in too many fields. The main attributes to represent as well index the images are color, shape, texture, spatial layout. These features of images are extracted to check similarity among the images. Generation of special query is the main problem of content based ...

  14. Value-based metrics and Internet-based enterprises

    Science.gov (United States)

    Gupta, Krishan M.

    2001-10-01

    Within the last few years, a host of value-based metrics like EVA, MVA, TBR, CFORI, and TSR have evolved. This paper attempts to analyze the validity and applicability of EVA and Balanced Scorecard for Internet based organizations. Despite the collapse of the dot-com model, the firms engaged in e- commerce continue to struggle to find new ways to account for customer-base, technology, employees, knowledge, etc, as part of the value of the firm. While some metrics, like the Balance Scorecard are geared towards internal use, others like EVA are for external use. Value-based metrics are used for performing internal audits as well as comparing firms against one another; and can also be effectively utilized by individuals outside the firm looking to determine if the firm is creating value for its stakeholders.

  15. Content-Based Image Retrial Based on Hadoop

    OpenAIRE

    DongSheng Yin; DeBo Liu

    2013-01-01

    Generally, time complexity of algorithms for content-based image retrial is extremely high. In order to retrieve images on large-scale databases efficiently, a new way for retrieving based on Hadoop distributed framework is proposed. Firstly, a database of images features is built by using Speeded Up Robust Features algorithm and Locality-Sensitive Hashing and then perform the search on Hadoop platform in a parallel way specially designed. Considerable experimental results show that it is abl...

  16. On Knowledge Excavation Based on University Library Knowledge Base

    OpenAIRE

    Ying Song

    2009-01-01

    Knowledge excavation is a new information processing technology. Nowadays, knowledge excavation has been widely applied to the university library management. Knowledge excavation in university library knowledge bases has already been playing an important role in improving the management of university libraries and inevitably will play a more profound role in the future. In this paper, the meaning of knowledge excavation in university library knowledge bases and other related issues are studie...

  17. Implementation of activity based cost management aboard base installations

    OpenAIRE

    Stanley, James; Perkins, Nicholas R.; Zander, Laura

    2004-01-01

    Approved for public release; distribution is unlimited. MBA Professional Report This project is a comparative analysis of the implementation process of Activity Based Cost Management of Marine Corps Logistics Base, (MCLB), Albany, and the implementation procedures used aboard MCB Camp Lejeune. Interviews and data gathering were conducted to identify how the respective Business Performance Offices (BPO), plan, implement, monitor, and measure performance of their process to introduce ABCM...

  18. Region-based multimodal image fusion using ICA bases

    OpenAIRE

    Cvejic, N; Lewis, J.; Bull, DR; Canagarajah, CN

    2006-01-01

    In this paper, we present a novel region-based multimodal image fusion algorithm in the ICA domain. It uses segmentation to determine the most important regions in the input images and consequently fuses the ICA coefficients from the given regions. The proposed method exhibits considerably higher performance than the basic ICA algorithm and shows improvement over other state-of-the-art algorithms In this paper, we present a novel region-based multimodal image fusion algorithm in the ICA do...

  19. Trace-Based Code Generation for Model-Based Testing

    OpenAIRE

    Kanstrén, T.; Piel, E.; Gross, H.-G.

    2009-01-01

    Paper Submitted for review at the Eighth International Conference on Generative Programming and Component Engineering. Model-based testing can be a powerful means to generate test cases for the system under test. However, creating a useful model for model-based testing requires expertise in the (formal) modeling language of the used tool and the general concept of modeling the system under test for effective test generation. A commonly used modeling notation is to describe the model through a...

  20. Object-Based Benefits without Object-Based Representations

    OpenAIRE

    Alvarez, George Angelo; Fougnie, Daryl; Cormiea, Sarah M

    2012-01-01

    The organization of visual information into objects strongly influences visual memory: Displays with objects defined by two features (e.g. color, orientation) are easier to remember than displays with twice as many objects defined by one feature (Olson & Jiang, 2002). Existing theories suggest that this ‘object-benefit’ is based on object-based limitations in working memory: because a limited number of objects can be stored, packaging features together so that fewer objects have to be remembe...

  1. Matroid intersection, base packing and base covering for infinite matroids

    OpenAIRE

    Bowler, Nathan; Carmesin, Johannes

    2012-01-01

    As part of the recent developments in infinite matroid theory, there have been a number of conjectures about how standard theorems of finite matroid theory might extend to the infinite setting. These include base packing, base covering, and matroid intersection and union. We show that several of these conjectures are equivalent, so that each gives a perspective on the same central problem of infinite matroid theory. For finite matroids, these equivalences give new and simpler proofs for the f...

  2. G -Frames, g -orthonormal bases and g -Riesz bases

    Directory of Open Access Journals (Sweden)

    Seyedeh Sara Karimizad

    2014-05-01

    Full Text Available G-Frames in Hilbert spaces are a redundant set of operators which yield a repre-sentation for each vector in the space. In this paper we investigate the connection betweeng-frames, g-orthonormal bases and g-Riesz bases. We show that a family of bounded opera-tors is a g-Bessel sequences if and only if the Gram matrix associated to its denes a bounded operator

  3. Knowledge base system visualization reasoning model based on ICON

    Science.gov (United States)

    Chen, Deyun; Pei, Shujun; Quan, Zhiying

    2005-03-01

    Knowledge base system is one of the most future branches for artificial intelligence facing with practical application. But the reasoning process of system is invisible, not visual and users cannot intervene the reasoning process, therefore for users the system is only a black box. This condition causes many users to take a suspicious attitude to the conclusions analyzing and drawing from the system, that means even though the system has the explanation function, but it is still not far enough. If we adopt graph or image technique to display this reasoning procedure interactively and dynamically which can make this procedure be visual, users can intervene the reasoning procedure which can greatly reduce users" gain giving, and at the same time it can provide a given method for integrity check to knowledge of the knowledge base. Therefore, we can say that reasoning visualization of knowledge base system has a further meaning than general visualization. In this paper the visual problem of reasoning process for knowledge base system on the basis of the formalized analysis for ICON system, Icon operation, syntax and semanteme of the statement is presented, a reasoning model of knowledge base system that has a visual characteristics is established, the model is used to do an integrity check in practical expert system and knowledge base, better effect is got.

  4. Home-based Healthcare Technology

    DEFF Research Database (Denmark)

    Verdezoto, Nervo

    Sustaining daily, unsupervised healthcare activities in non-clinical settings such as the private home can challenge, among others, older adults. To support such unsupervised care activities, an increasingly number of reminders and monitoring systems are being designed. However, most of these...... systems target a specific treatment or condition and might not be sufficient to support the care management work at home. Based on a case study approach, my research investigates home-based healthcare practices and how they can inform future design of home-based healthcare technology that better account...... for the home setting and people’s everyday activities....

  5. Flow tracing based on current

    Institute of Scientific and Technical Information of China (English)

    蔡兴国; 曹海龙

    2001-01-01

    Analyses the flow tracing based on power flow, points out that the detachment of reactive power and active power is unrealiable and concludes that the current is the real basic of flow tracing,and proposes the new flow tracing model based on current, which devides the current into active current and reactive current, analyses the theory about the matrix to deal with the precision and realization of the flow tracing, and then proposes a new pricing model by fixed rate and marginal rate, which keeps not only economy information such as congestion cost in marginal cost based pricing, but also benefits to make both ends meet.

  6. Risk-based safety indicators

    International Nuclear Information System (INIS)

    The report is structured as follows: 1. Risk-based safety indicators: Typology of risk-based indicators (RBIs); Tools for defining RBIs; Requirements for the PSA model; Data sources for RBIs; Types of risks monitored; RBIs and operational safety indicators; Feedback from operating experience; PSO model modification for RBIs; RBI categorization; RBI assessment; RBI applications; Suitable RBI applications. 2. Proposal for risk-based indicators: Acquiring information from operational experience; Method of acquiring safety relevance coefficients for the systems from a PSA model; Indicator definitions; On-line indicators. 3. Annex: Application of RBIs worldwide. (P.A.)

  7. PBW bases and KLR algebras

    OpenAIRE

    Kato, Syu

    2012-01-01

    We generalize Lusztig's geometric construction of the PBW bases of finite quantum groups of type $\\mathsf{ADE}$ under the framework of [Varagnolo-Vasserot, J. reine angew. Math. 659 (2011)]. In particular, every PBW basis of such quantum groups is proven to yield a semi-orthogonal collection in the module category of the KLR-algebras. This enables us to prove Lusztig's conjecture on the positivity of the canonical (lower global) bases in terms of the (lower) PBW bases in the $\\mathsf{ADE}$ ca...

  8. Mitochondrial base excision repair assays

    DEFF Research Database (Denmark)

    Maynard, Scott; de Souza-Pinto, Nadja C; Scheibye-Knudsen, Morten;

    2010-01-01

    The main source of mitochondrial DNA (mtDNA) damage is reactive oxygen species (ROS) generated during normal cellular metabolism. The main mtDNA lesions generated by ROS are base modifications, such as the ubiquitous 8-oxoguanine (8-oxoG) lesion; however, base loss and strand breaks may also occur....... Many human diseases are associated with mtDNA mutations and thus maintaining mtDNA integrity is critical. All of these lesions are repaired primarily by the base excision repair (BER) pathway. It is now known that mammalian mitochondria have BER, which, similarly to nuclear BER, is catalyzed by DNA...

  9. Office-based laryngeal injections.

    Science.gov (United States)

    Mallur, Pavan S; Rosen, Clark A

    2013-02-01

    Office-based vocal fold injection (VFI), though initially described more than a century ago, has recently reemerged as an attractive alternative to VFI performed during microsuspension laryngoscopy. Multiple office-based approaches exist, including percutaneous, peroral, and transnasal endoscopic approaches. Surgeon preference typically dictates the approach, although patient tolerance or anatomic variations are also key factors. Regardless of the approach or indication, a myriad of technical considerations make preparation and familiarity requisite for optimal patient outcomes. Office-based VFI offers several distinct advantages over traditional direct or microsuspension laryngoscopy VFI, making it a standard of treatment for a variety of indications. PMID:23177408

  10. Eye-based head gestures

    DEFF Research Database (Denmark)

    Mardanbegi, Diako; Witzner Hansen, Dan; Pederson, Thomas

    A novel method for video-based head gesture recognition using eye information by an eye tracker has been proposed. The method uses a combination of gaze and eye movement to infer head gestures. Compared to other gesture-based methods a major advantage of the method is that the user keeps the gaze...... on the interaction object while interacting. This method has been implemented on a head-mounted eye tracker for detecting a set of predefined head gestures. The accuracy of the gesture classifier is evaluated and verified for gaze-based interaction in applications intended for both large public...

  11. Seeing graphene-based sheets

    Directory of Open Access Journals (Sweden)

    Jaemyung Kim

    2010-03-01

    Full Text Available Graphene-based sheets such as graphene, graphene oxide and reduced graphene oxide have stimulated great interest due to their promising electronic, mechanical and thermal properties. Microscopy imaging is indispensable for characterizing these single atomic layers, and oftentimes is the first measure of sample quality. This review provides an overview of current imaging techniques for graphene-based sheets and highlights a recently developed fluorescence quenching microscopy technique that allows high-throughput, high-contrast imaging of graphene-based sheets on arbitrary substrate and even in solution.

  12. Solar based hydrogen production systems

    CERN Document Server

    Dincer, Ibrahim

    2013-01-01

    This book provides a comprehensive analysis of various solar based hydrogen production systems. The book covers first-law (energy based) and second-law (exergy based) efficiencies and provides a comprehensive understanding of their implications. It will help minimize the widespread misuse of efficiencies among students and researchers in energy field by using an intuitive and unified approach for defining efficiencies. The book gives a clear understanding of the sustainability and environmental impact analysis of the above systems. The book will be particularly useful for a clear understanding

  13. Export base of czech regions

    OpenAIRE

    Michal Šulc

    2010-01-01

    This article deals with the analysis of structure and size of goods exported from the Czech regions in the period of 2003–2009. The analysis is related to the export base theory. At first there is the export base theory characterised in the beginning of the article. There is a limited data base for the assessing of international flow of goods and services in case of Czech regions, for only the data of exported goods is regionally monitored. Both the presence and the increase of importance of ...

  14. Formal Component-Based Semantics

    CERN Document Server

    Madlener, Ken; van Eekelen, Marko; 10.4204/EPTCS.62.2

    2011-01-01

    One of the proposed solutions for improving the scalability of semantics of programming languages is Component-Based Semantics, introduced by Peter D. Mosses. It is expected that this framework can also be used effectively for modular meta theoretic reasoning. This paper presents a formalization of Component-Based Semantics in the theorem prover Coq. It is based on Modular SOS, a variant of SOS, and makes essential use of dependent types, while profiting from type classes. This formalization constitutes a contribution towards modular meta theoretic formalizations in theorem provers. As a small example, a modular proof of determinism of a mini-language is developed.

  15. Industry Based Survey (IBS) Yellowtail

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The "Southern New England Yellowtail Flounder Industry-Based Survey" was a collaboration between the Rhode Island Division of Fish and Wildlife and the fishing...

  16. Mindfulness-Based Stress Reduction

    Science.gov (United States)

    ... R S T U V W X Y Z Mindfulness-Based Stress Reduction (MBSR) Information 5 Things You ... Better Than Usual Care Alone (03/22/16) Mindfulness Meditation May Benefit People With Chronic Insomnia (09/ ...

  17. Consumption-based Equity Valuation

    DEFF Research Database (Denmark)

    Bach, Christian; Christensen, Peter Ove

    2013-01-01

    Using a CCAPM-based risk-adjustment model consistent with general asset pricing theory, we perform yearly valuations of a large sample of stocks listed on NYSE, AMEX and NASDAQ over a thirty-year period. The model differs from standard valuation models in the sense that it adjusts forecasted...... residual income for risk in the numerator rather than through a risk-adjusted cost of equity in the denominator. The risk-adjustments are derived based on assumptions about the time-series properties of residual income returns and aggregate consumption rather than on historical stock returns. We compare...... the performance of the model with several implementations of standard valuation models, both in terms of absolute valuation errors, and in terms of the returns on simple investment strategies based on the differences between model and market prices in the respective valuation models. The CCAPM-based valuation...

  18. Industry Based Survey (IBS) Cod

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The "Gulf of Maine Atlantic Cod Industry-Based Survey" was a collaboration of the Massachusetts Division of Marine Fisheries and the fishing industry, with support...

  19. Chip-based droplet sorting

    Energy Technology Data Exchange (ETDEWEB)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2014-07-01

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  20. Random Decrement Based FRF Estimation

    DEFF Research Database (Denmark)

    Brincker, Rune; Asmussen, J. C.

    The problem of estimating frequency response functions and extracting modal parameters is the topic of this paper. A new method based on the Random Decrement technique combined with Fourier transformation and the traditional pure Fourier transformation based approach is compared with regard to...... speed and quality. The basis of the new method is the Fourier transformation of the Random Decrement functions which can be used to estimate the frequency response functions. The investigations are based on load and response measurements of a laboratory model of a 3 span bridge. By applying both methods...... to these measurements the estimation time of the frequency response functions can be compared. The modal parameters estimated by the methods are compared. It is expected that the Random Decrement technique is faster than the traditional method based on pure Fourier Transformations. This is due to the...

  1. Random Decrement Based FRF Estimation

    DEFF Research Database (Denmark)

    Brincker, Rune; Asmussen, J. C.

    1997-01-01

    The problem of estimating frequency response functions and extracting modal parameters is the topic of this paper. A new method based on the Random Decrement technique combined with Fourier transformation and the traditional pure Fourier transformation based approach is compared with regard to...... speed and quality. The basis of the new method is the Fourier transformation of the Random Decrement functions which can be used to estimate the frequency response functions. The investigations are based on load and response measurements of a laboratory model of a 3 span bridge. By applying both methods...... to these measurements the estimation time of the frequency response functions can be compared. The modal parameters estimated by the methods are compared. It is expected that the Random Decrement technique is faster than the traditional method based on pure Fourier Transformations. This is due to the...

  2. Oil-based paint poisoning

    Science.gov (United States)

    Paint - oil based - poisoning ... Hydrocarbons are the primary poisonous ingredient in oil paints. Some oil paints have heavy metals such as lead, mercury, cobalt, and barium added as pigment. These heavy metals can cause additional ...

  3. FEMA DFIRM Base Flood Elevations

    Data.gov (United States)

    Minnesota Department of Natural Resources — The Base Flood Elevation (BFE) table is required for any digital data where BFE lines will be shown on the corresponding Flood Insurance Rate Map (FIRM). Normally,...

  4. Base Flow Model Validation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The program focuses on turbulence modeling enhancements for predicting high-speed rocket base flows. A key component of the effort is the collection of...

  5. Chip-based droplet sorting

    Science.gov (United States)

    Beer, Neil Reginald; Lee, Abraham; Hatch, Andrew

    2014-07-01

    A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

  6. Content Based Video Retrieval Systems

    Directory of Open Access Journals (Sweden)

    B V Patel

    2012-05-01

    Full Text Available With the development of multimedia data types and available bandwidth there is huge demand of video retrieval systems, as users shift from text based retrieval systems to content based retrieval systems. Selection of extracted features play an important role in content based video retrieval regardless of video attributes being under consideration. These features are intended for selecting, indexing and ranking according to their potential interest to the user. Good features selection also allows the time and space costs of the retrieval process to be reduced. This survey reviews the interesting features that can beextracted from video data for indexing and retrieval along with similarity measurement methods. We also identify present research issues in area of content based video retrieval systems.

  7. Graph Model Based Indoor Tracking

    DEFF Research Database (Denmark)

    Jensen, Christian Søndergaard; Lu, Hua; Yang, Bin

    2009-01-01

    The tracking of the locations of moving objects in large indoor spaces is important, as it enables a range of applications related to, e.g., security and indoor navigation and guidance. This paper presents a graph model based approach to indoor tracking that offers a uniform data management...... infrastructure for different symbolic positioning technologies, e.g., Bluetooth and RFID. More specifically, the paper proposes a model of indoor space that comprises a base graph and mappings that represent the topology of indoor space at different levels. The resulting model can be used for one or several...... indoor positioning technologies. Focusing on RFID-based positioning, an RFID specific reader deployment graph model is built from the base graph model. This model is then used in several algorithms for constructing and refining trajectories from raw RFID readings. Empirical studies with implementations...

  8. On Bohr-Sommerfeld bases

    International Nuclear Information System (INIS)

    This paper combines algebraic and Lagrangian geometry to construct a special basis in every space of conformal blocks, the Bohr-Sommerfeld (BS) basis. We use the method of Borthwick-Paul-Uribe, in which every vector of a BS basis is determined by some half-weight Legendrian distribution coming from a Bohr-Sommerfeld fibre of a real polarization of the underlying symplectic manifold. The advantage of BS bases (compared to the bases of theta functions) is that we can use the powerful methods of asymptotic analysis of quantum states. This shows that Bohr-Sommerfeld bases are quasiclassically unitary. Thus we can apply these bases to compare the Hitchin connection and the KZ connection defined by the monodromy of the Knizhnik-Zamolodchikov equation in the combinatorial theory

  9. Competency-Based Accounting Instruction

    Science.gov (United States)

    Graham, John E.

    1977-01-01

    Shows how the proposed model (an individualized competency based learning system) can be used effectively to produce a course in accounting principles which adapts to different entering competencies and to different rates and styles of learning. (TA)

  10. Consent Based Verification System (CBSV)

    Data.gov (United States)

    Social Security Administration — CBSV is a fee-based service offered by SSA's Business Services Online (BSO). It is used by private companies to verify the SSNs of their customers and clients that...

  11. The Knowledge Based Information Economy

    OpenAIRE

    Eliasson, Gunnar; Fölster, Stefan; Lindberg, Thomas; Pousette, Tomas; Erol TAYMAZ

    1990-01-01

    Working Paper No. 256 is published as "The Knowledge Based Information Economy" (authors: Gunnar Eliasson, Stefan Fölster, Thomas Lindberg, Tomas Pousette and Erol Taymaz). Stockholm: Industrial Institute for Economic and Social Research and Telecon, 1990.

  12. Cage-based performance capture

    CERN Document Server

    Savoye, Yann

    2014-01-01

    Nowadays, highly-detailed animations of live-actor performances are increasingly easier to acquire and 3D Video has reached considerable attentions in visual media production. In this book, we address the problem of extracting or acquiring and then reusing non-rigid parametrization for video-based animations. At first sight, a crucial challenge is to reproduce plausible boneless deformations while preserving global and local captured properties of dynamic surfaces with a limited number of controllable, flexible and reusable parameters. To solve this challenge, we directly rely on a skin-detached dimension reduction thanks to the well-known cage-based paradigm. First, we achieve Scalable Inverse Cage-based Modeling by transposing the inverse kinematics paradigm on surfaces. Thus, we introduce a cage inversion process with user-specified screen-space constraints. Secondly, we convert non-rigid animated surfaces into a sequence of optimal cage parameters via Cage-based Animation Conversion. Building upon this re...

  13. US Air Force Base Observations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hourly observations taken by U.S. Air Force personnel at bases in the United States and around the world. Foreign observations concentrated in the Middle East and...

  14. Hospital Value-Based Purchasing

    Data.gov (United States)

    U.S. Department of Health & Human Services — Hospital Value-Based Purchasing (VBP) is part of the Centers for Medicare and Medicaid Services (CMS) long-standing effort to link Medicares payment system to a...

  15. Leather inspection based on wavelets

    OpenAIRE

    Sobral, João Luís Ferreira

    2005-01-01

    This paper presents a new methodology to detect leather defects, based on the wavelet transform. The methodology uses a bank of optimised filters, where each filter is tuned to one defect type. Filter shape and wavelet sub-band are selected based the maximisation of the ratio between features values on defect regions and on normal regions. The proposed methodology can detect defects even when small features variations are present, which are not detect by generic texture classification techniq...

  16. Entropy-based benchmarking methods

    OpenAIRE

    Temurshoev, Umed

    2012-01-01

    We argue that benchmarking sign-volatile series should be based on the principle of movement and sign preservation, which states that a bench-marked series should reproduce the movement and signs in the original series. We show that the widely used variants of Denton (1971) method and the growth preservation method of Causey and Trager (1981) may violate this principle, while its requirements are explicitly taken into account in the pro-posed entropy-based benchmarking methods. Our illustrati...

  17. Identity Based Color Image Cryptography

    OpenAIRE

    Gopi Krishnan S; Loganathan D

    2011-01-01

    An Identity based cryptography based on visual cryptography scheme was proposed for protecting color image. A color image to be protected and authentic entities such as account number, password, signature image are given as input. The binary key image is obtained by distributing the digital signature of obtained authentic entities. A secret color image which needs to be communicated is decomposed into three grayscale tones of Y-Cb-Cr color component. Then these grayscale images are half-toned...

  18. LC-MS-based metabolomics

    OpenAIRE

    Zhou, Bin; Xiao, Jun Feng; Tuli, Leepika; Ressom, Habtom W

    2011-01-01

    Metabolomics aims at identification and quantitation of small molecules involved in metabolic reactions. LC-MS has enjoyed a growing popularity as the platform for metabolomic studies due to its high throughput, soft ionization, and good coverage of metabolites. The success of LC-MS-based metabolomic study often depends on multiple experimental, analytical, and computational steps. This review presents a workflow of a typical LC-MS-based metabolomic analysis for identification and quantitatio...

  19. PIN-based cancelable biometrics

    OpenAIRE

    Lacharme, Patrick; Plateaux, Aude

    2011-01-01

    Biometric authentication systems are more and more deployed in replacement of traditional authentication systems. Security of such systems is required in real- world applications and constitutes a major challenge in biometric field. An ef- ficient approach of this issue is realized by cancelable biometrics. However, the security of such biometric systems is often overestimated or based on restrictive as- sumptions. This paper presents and investigates a PIN-based variant for cancelable biometri...

  20. Seeing graphene-based sheets

    OpenAIRE

    Jaemyung Kim; Franklin Kim; Jiaxing Huang

    2010-01-01

    Graphene-based sheets such as graphene, graphene oxide and reduced graphene oxide have stimulated great interest due to their promising electronic, mechanical and thermal properties. Microscopy imaging is indispensable for characterizing these single atomic layers, and oftentimes is the first measure of sample quality. This review provides an overview of current imaging techniques for graphene-based sheets and highlights a recently developed fluorescence quenching microscopy technique that al...

  1. CORBA Based CIMS Application Integration

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Common object request broker architecture (CORBA) provides the framework and the mechanism for distributed object operation. It can also be applied to computer integrated manufacturing system (CIMS) application integration. This paper studies the CIMS information service requirement, presents a CORBA based integration approach including the CORBA based CIM information system architecture and the application integration mechanism, and discusses the relationship between CORBA and the CIM application integration platform.

  2. Studying Sensing-Based Systems

    DEFF Research Database (Denmark)

    Kjærgaard, Mikkel Baun

    2013-01-01

    Recent sensing-based systems involve a multitude of users, devices, and places. These types of systems challenge existing approaches for conducting valid system evaluations. Here, the author discusses such evaluation challenges and revisits existing system evaluation methodologies.......Recent sensing-based systems involve a multitude of users, devices, and places. These types of systems challenge existing approaches for conducting valid system evaluations. Here, the author discusses such evaluation challenges and revisits existing system evaluation methodologies....

  3. Knowledge Management Based on ERP

    OpenAIRE

    Qian Feng; Yuanyuan Huang

    2009-01-01

    In an information explosive era, knowledge management has become a hot field in enterprise informatization. In order to adapt to the competitive environment, it is now an urgent task to add knowledge management to ERP system and integrate learning and innovation on the platform of enterprise information system based on ERP. This paper focuses on knowledge management based on ERP and introduces a knowledge management system: KRM.

  4. Uranium-Based Cermet Alloys

    International Nuclear Information System (INIS)

    The paper describes certain features of dispersion-hardened uranium-based cermets. As possible hardening materials, consideration was given to UO2, UC, Al2O3, MgO and UBe13. Data were obtained on the behaviour of uranium alloys containing the above-mentioned admixtures during creep tests, short-term strength tests and cyclic thermal treatment. The corrosion resistance o f UBe13-based uranium alloys was also studied. )author)

  5. Fuzzy Bases of Fuzzy Domains

    OpenAIRE

    Sanping Rao; Qingguo Li

    2013-01-01

    This paper is an attempt to develop quantitative domain theory over frames. Firstly, we propose the notion of a fuzzy basis, and several equivalent characterizations of fuzzy bases are obtained. Furthermore, the concept of a fuzzy algebraic domain is introduced, and a relationship between fuzzy algebraic domains and fuzzy domains is discussed from the viewpoint of fuzzy basis. We finally give an application of fuzzy bases, where the image of a fuzzy domain can be preserved under some special ...

  6. Template-Based Active Contours

    OpenAIRE

    Mogali, Jayanth Krishna; Pediredla, Adithya Kumar; Seelamantula, Chandra Sekhar

    2013-01-01

    We develop a generalized active contour formalism for image segmentation based on shape templates. The shape template is subjected to a restricted affine transformation (RAT) in order to segment the object of interest. RAT allows for translation, rotation, and scaling, which give a total of five degrees of freedom. The proposed active contour comprises an inner and outer contour pair, which are closed and concentric. The active contour energy is a contrast function defined based on the intens...

  7. Brain plasticity-based therapeutics

    OpenAIRE

    Merzenich, Michael M.; Van Vleet, Thomas M.; Nahum, Mor

    2014-01-01

    The primary objective of this review article is to summarize how the neuroscience of brain plasticity, exploiting new findings in fundamental, integrative and cognitive neuroscience, is changing the therapeutic landscape for professional communities addressing brain-based disorders and disease. After considering the neurological bases of training-driven neuroplasticity, we shall describe how this neuroscience-guided perspective distinguishes this new approach from (a) the more-behavioral, tra...

  8. Brain Plasticity-Based Therapeutics

    OpenAIRE

    Michael eMerzenich; Mor eNahum; Tom eVan Vleet

    2014-01-01

    The primary objective of this review article is to summarize how the neuroscience of brain plasticity, exploiting new findings in fundamental, integrative and cognitive neuroscience, is changing the therapeutic landscape for professional communities addressing brain-based disorders and disease. After considering the neurological bases of training-driven neuroplasticity, we shall describe how this neuroscience-guided perspective distinguishes this new approach from a) the more-behavioral, trad...

  9. Knowledge-based Telecom Industry

    OpenAIRE

    Vinje, Villeman; Nordkvelde, Marius

    2011-01-01

    BI Norwegian School of Management is conducting a national research project entitled “A knowledge-based Norway”. Thirteen major knowledge-based industries in Norway are being analyzed under the auspices of the project. This study assesses the underlying properties of a global knowledge hub to examine the extent to which the Norwegian telecom industry – which encompasses all telecom firms located in Norway regardless of ownership – constitutes a global knowledge hub. It commences with a ge...

  10. Ridge-based fingerprint matching

    OpenAIRE

    Pohar, Jaka

    2013-01-01

    The diploma thesis presents an upgrade of the FingerIdent fingerprint verification system. The current version of the system uses a minutia matching procedure for comparison of two fingerprints. In order to improve the security of the system we have implemented an additional matching procedure which is based on the use of fingerprint ridges. Algorithm inputs are lists of ridge points of two fingerprints. At the beginning the algorithm searches the initial base ridge pair and matches it. Th...

  11. Base isolation of fluid containers

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S. [Cygna Group Inc./ICF Kaiser International, Oakland, CA (United States)

    1995-12-01

    Fluid containers often constitute critical internal equipment in power plants. However, due to possible structure-equipment interaction effect they are particularly vulnerable during strong earthquake events. An effective technique for protecting fluid containers is base isolation. By deflecting the possible seismic input energy into the superstructure, base isolation can substantially reduce seismic demand on the containers, making it more cost effective than equivalent conventional design.

  12. A hybrid base isolation system

    Energy Technology Data Exchange (ETDEWEB)

    Hart, G.C. [Univ. of California, Los Angeles, CA (United States); Lobo, R.F.; Srinivasan, M. [Hart Consultant Group, Santa Monica, CA (United States); Asher, J.W. [kpff Engineers, Santa Monica, CA (United States)

    1995-12-01

    This paper proposes a new analysis procedure for hybrid base isolation buildings when considering the displacement response of a base isolated building to wind loads. The system is considered hybrid because of the presence of viscous dampers in the building above the isolator level. The proposed analysis approach incorporates a detailed site specific wind study combined with a dynamic nonlinear analysis of the building response.

  13. Base isolation of fluid containers

    International Nuclear Information System (INIS)

    Fluid containers often constitute critical internal equipment in power plants. However, due to possible structure-equipment interaction effect they are particularly vulnerable during strong earthquake events. An effective technique for protecting fluid containers is base isolation. By deflecting the possible seismic input energy into the superstructure, base isolation can substantially reduce seismic demand on the containers, making it more cost effective than equivalent conventional design

  14. Fragment-based lead design

    Science.gov (United States)

    Filz, O. A.; Poroikov, Vladimir V.

    2012-02-01

    State-of-the-art approaches to the fragment-based design of organic compounds with desired properties are considered. The review covers methods, which are used in different steps of the design, such as computational methods for fragment library design, experimental and computational methods for fragment discovery and methods for the generation of structures of organic compounds. Examples are given of drug candidates, which were constructed using the fragment-based approach. The bibliography includes 156 references.

  15. Evidence-based clinical practice

    DEFF Research Database (Denmark)

    Gluud, Christian

    2002-01-01

    Evidence-based medicine combines the patient's preferences with clinical experience and the best research evidence. Randomized clinical trials are considered the most valid research design for evaluating health-care interventions. However, empirical research shows that intervention effects may be...... evidence in clinical practice. By investments in education, applied research, and The Cochrane Collaboration, evidence-based medicine may form a stronger basis for clinical practice....

  16. Detector Based Radio Tomographic Imaging

    OpenAIRE

    Yiğitler, Hüseyin; Jäntti, Riku; Kaltiokallio, Ossi; Patwari, Neal

    2016-01-01

    Received signal strength based radio tomographic imaging is a popular device-free indoor localization method which reconstructs the spatial loss field of the environment using measurements from a dense wireless network. Existing methods solve an associated inverse problem using algebraic or compressed sensing reconstruction algorithms. We propose an alternative imaging method that reconstructs spatial field of occupancy using a back-projection based reconstruction algorithm. The introduced sy...

  17. Donor Schiff Base Polymeric Complexes

    Directory of Open Access Journals (Sweden)

    Shubhangi N. Kotkar

    2013-01-01

    Full Text Available A series of new polymeric complexes of Mn(II, Co(II, Ni(II, Cu(II, and Zn(II were prepared with a Schiff base ligand derived from condensation of 2,4-dihydroxy acetophenone and p-phenylene diamine and characterized by elemental analysis and IR and NMR spectral data. The antimicrobial activity of the Schiff base and its polymeric complexes have been studied.

  18. Osmium-Based Pyrimidine Contrast Tags for Enhanced Nanopore-Based DNA Base Discrimination.

    Directory of Open Access Journals (Sweden)

    Robert Y Henley

    Full Text Available Nanopores are a promising platform in next generation DNA sequencing. In this platform, an individual DNA strand is threaded into nanopore using an electric field, and enzyme-based ratcheting is used to move the strand through the detector. During this process the residual ion current through the pore is measured, which exhibits unique levels for different base combinations inside the pore. While this approach has shown great promise, accuracy is not optimal because the four bases are chemically comparable to one another, leading to small differences in current obstruction. Nucleobase-specific chemical tagging can be a viable approach to enhancing the contrast between different bases in the sequence. Herein we show that covalent modification of one or both of the pyrimidine bases by an osmium bipyridine complex leads to measureable differences in the blockade amplitudes of DNA molecules. We qualitatively determine the degree of osmylation of a DNA strand by passing it through a solid-state nanopore, and are thus able to gauge T and C base content. In addition, we show that osmium bipyridine reacts with dsDNA, leading to substantially different current blockade levels than exhibited for bare dsDNA. This work serves as a proof of principle for nanopore sequencing and mapping via base-specific DNA osmylation.

  19. Investigation into the use of 1,2-diamines in fused heterocycle synthesis

    OpenAIRE

    Noble, A.

    2012-01-01

    The introductory chapter of this thesis gives a brief outline of the literature concerning the importance of 1,2-diamines. This includes their biological significance, their successful application to synthetic chemistry, especially in asymmetric synthesis, and methods available for their preparation. One particular method, the nitro-Mannich reaction, is reviewed in more detail. The synthetic utility of the products of the nitro-Mannich reaction is demonstrated by their application to the synt...

  20. Instantaneous noise-based logic

    CERN Document Server

    Kish, Laszlo B; Peper, Ferdinand

    2010-01-01

    We show two universal, Boolean, deterministic logic schemes based on binary noise timefunctions that can be realized without time averaging units. The first scheme is based on a new bipolar random telegraph wave scheme and the second one makes use of the recent noise-based logic which is conjectured to be the brain's method of logic operations [Physics Letters A 373 (2009) 2338-2342, arXiv:0902.2033]. For binary-valued logic operations, the two simple Boolean schemes presented in this paper use zero (no noise) for the logic Low (L) state. In the random telegraph wave-based scheme, for multi-valued logic operations, additive superpositions of logic states must be avoided, while multiplicative superpositions utilizing hyperspace base vectors can still be utilized. These modifications, while keeping the information richness of multi-valued (noise-based) logic, result in a significant speedup of logic operations for the same signal bandwidth. The logic hyperspace of the first scheme results random telegraph waves...

  1. Polyurethane Based Inhibition for High Flame Temperature Nitramine Based Composite Modified Double Base propellant

    Directory of Open Access Journals (Sweden)

    S. D. Kakade

    1998-10-01

    Full Text Available The findings for polypropylene glycol (PPG and hydroxyl-terminated polybutadiene (HTPB-based inhibition systems are reported. These findings established that the inhibition system comprising HTPB-IPDI-IDP binder and Sb/sub 2/O/sub 3/-C black filler is most suitable for advanced nitramine-based composite modified double-base propellants in terms of mechanical properties and processibility. The promising composition was characterised for glass-transition behaviour and propellant-inhibition bond strength. Propellant grains inhibited with selected formulations were subjected to static evaluation at extreme temperatures and limited aging studies to obtain data of practical value.

  2. From conventional software based systems to knowledge based systems

    International Nuclear Information System (INIS)

    Even if todays nuclear power plants have a very good safety record, there is a continuous search for still improving safety. One direction of this effort address operational safety, trying to improve the handling of disturbances and accidents partly by further automation, partly by creating a better control room environment, providing the operator with intelligent support systems to help in the decision making process. Introduction of intelligent computerised operator support systems has proved to be an efficient way of improving the operators performance. A number of systems have been developed worldwide, assisting in tasks like process fault detection and diagnosis, selection and implementation of proper remedial actions. Unfortunately, the use of Knowledge Based Systems (KBSs), introduces a new dimension to the problem of the licensing process. KBSs, despite the different technology employed, are still nothing more than a computer program. Unfortunately, quite a few people building knowledge based systems seem to ignore the many good programming practices that have evolved over the years for producing traditional computer programs. In this paper the author will try to point out similarities and differences between conventional software based systems, and knowledge based systems, introducing also the concept of model based reasoning. (orig.) (25 refs., 2 figs.)

  3. Cost-Based Vectorization of Instance-Based Integration Processes

    Science.gov (United States)

    Boehm, Matthias; Habich, Dirk; Preissler, Steffen; Lehner, Wolfgang; Wloka, Uwe

    The inefficiency of integration processes—as an abstraction of workflow-based integration tasks—is often reasoned by low resource utilization and significant waiting times for external systems. With the aim to overcome these problems, we proposed the concept of process vectorization. There, instance-based integration processes are transparently executed with the pipes-and-filters execution model. Here, the term vectorization is used in the sense of processing a sequence (vector) of messages by one standing process. Although it has been shown that process vectorization achieves a significant throughput improvement, this concept has two major drawbacks. First, the theoretical performance of a vectorized integration process mainly depends on the performance of the most cost-intensive operator. Second, the practical performance strongly depends on the number of available threads. In this paper, we present an advanced optimization approach that addresses the mentioned problems. Therefore, we generalize the vectorization problem and explain how to vectorize process plans in a cost-based manner. Due to the exponential complexity, we provide a heuristic computation approach and formally analyze its optimality. In conclusion of our evaluation, the message throughput can be significantly increased compared to both the instance-based execution as well as the rule-based process vectorization.

  4. Description-based and experience-based decisions: individual analysis

    Directory of Open Access Journals (Sweden)

    Andrey Kudryavtsev

    2012-05-01

    Full Text Available We analyze behavior in two basic classes of decision tasks: description-based and experience-based. In particular, we compare the prediction power of a number of decision learning models in both kinds of tasks. Unlike most previous studies, we focus on individual, rather than aggregate, behavioral characteristics. We carry out an experiment involving a battery of both description- and experience-based choices between two mixed binary prospects made by each of the participants, and employ a number of formal models for explaining and predicting participants' choices: Prospect theory (PT (Kahneman and Tversky, 1979; Expectancy-Valence model (EVL (Busemeyer and Stout, 2002; and three combinations of these well-established models. We document that the PT and the EVL models are best for predicting people's decisions in description- and experience-based tasks, respectively, which is not surprising as these two models are designed specially for these kinds of tasks. Furthermore, we find that models involving linear weighting of gains and losses perform better in both kinds of tasks, from the point of view of generalizability and individual parameter consistency. We therefore, conclude that, overall, when both prospects are mixed, the assumption of diminishing sensitivity does not improve models' prediction power for individual decision-makers. Finally, for some of the models' parameters, we document consistency at the individual level between description- and experience-based tasks.

  5. Graph Cuts based Image Segmentation using Fuzzy Rule Based System

    Directory of Open Access Journals (Sweden)

    M. R. Khokher

    2012-12-01

    Full Text Available This work deals with the segmentation of gray scale, color and texture images using graph cuts. From input image, a graph is constructed using intensity, color and texture profiles of the image simultaneously. Based on the nature of image, a fuzzy rule based system is designed to find the weight that should be given to a specific image feature during graph development. The graph obtained from the fuzzy rule based weighted average of different image features is further used in normalized graph cuts framework. Graph is iteratively bi-partitioned through the normalized graph cuts algorithm to get optimum partitions resulting in the segmented image. Berkeley segmentation database is used to test our algorithm and the segmentation results are evaluated through probabilistic rand index, global consistency error, sensitivity, positive predictive value and Dice similarity coefficient. It is shown that the presented segmentation method provides effective results for most types of images.

  6. Image based Monument Recognition using Graph based Visual Saliency

    DEFF Research Database (Denmark)

    Kalliatakis, Grigorios; Triantafyllidis, Georgios

    2013-01-01

    This article presents an image-based application aiming at simple image classification of well-known monuments in the area of Heraklion, Crete, Greece. This classification takes place by utilizing Graph Based Visual Saliency (GBVS) and employing Scale Invariant Feature Transform (SIFT) or Speeded...... images have been previously processed according to the Graph Based Visual Saliency model in order to keep either SIFT or SURF features corresponding to the actual monuments while the background “noise” is minimized. The application is then able to classify these images, helping the user to better...... Up Robust Features (SURF). For this purpose, images taken at various places of interest are being compared to an existing database containing images of these places at different angles and zoom. The time required for the matching progress in such application is an important element. To this goal, the...

  7. Generalized eigenvalue based spectrum sensing

    KAUST Repository

    Shakir, Muhammad

    2012-01-01

    Spectrum sensing is one of the fundamental components in cognitive radio networks. In this chapter, a generalized spectrum sensing framework which is referred to as Generalized Mean Detector (GMD) has been introduced. In this context, we generalize the detectors based on the eigenvalues of the received signal covariance matrix and transform the eigenvalue based spectrum sensing detectors namely: (i) the Eigenvalue Ratio Detector (ERD) and two newly proposed detectors which are referred to as (ii) the GEometric Mean Detector (GEMD) and (iii) the ARithmetic Mean Detector (ARMD) into an unified framework of generalize spectrum sensing. The foundation of the proposed framework is based on the calculation of exact analytical moments of the random variables of the decision threshold of the respective detectors. The decision threshold has been calculated in a closed form which is based on the approximation of Cumulative Distribution Functions (CDFs) of the respective test statistics. In this context, we exchange the analytical moments of the two random variables of the respective test statistics with the moments of the Gaussian (or Gamma) distribution function. The performance of the eigenvalue based detectors is compared with the several traditional detectors including the energy detector (ED) to validate the importance of the eigenvalue based detectors and the performance of the GEMD and the ARMD particularly in realistic wireless cognitive radio network. Analytical and simulation results show that the newly proposed detectors yields considerable performance advantage in realistic spectrum sensing scenarios. Moreover, the presented results based on proposed approximation approaches are in perfect agreement with the empirical results. © 2012 Springer Science+Business Media Dordrecht.

  8. A passivity based controller for free base manipulators

    Science.gov (United States)

    Chuang, C.-H.; Mittal, Manoj; Juang, Jer-Nan

    1993-01-01

    A feedback linearization technique is used in conjunction with passivity concepts to design robust controllers for free base robots. It is assumed that bounded modeling uncertainties exist in the inertia matrix and the vector representing the coriolis, centripetal, and friction forces. Under these assumptions, the controller guarantees asymptotic tracking of the joint variables. A Lagrangian approach is used to develop a dynamic model for space robots. Closed-loop simulation results are illustrated for a simple case of a single link planar space manipulator with freely floating base.

  9. Characteristic properties of Fibonacci-based mutually unbiased bases

    Energy Technology Data Exchange (ETDEWEB)

    Seyfarth, Ulrich; Alber, Gernot [Institut fuer Angewandte Physik, Technische Universitaet Darmstadt, 64289 Darmstadt (Germany); Ranade, Kedar [Institut fuer Quantenphysik, Universitaet Ulm, Albert-Einstein-Allee 11, 89069 Ulm (Germany)

    2012-07-01

    Complete sets of mutually unbiased bases (MUBs) offer interesting applications in quantum information processing ranging from quantum cryptography to quantum state tomography. Different construction schemes provide different perspectives on these bases which are typically also deeply connected to various mathematical research areas. In this talk we discuss characteristic properties resulting from a recently established connection between construction methods for cyclic MUBs and Fibonacci polynomials. As a remarkable fact this connection leads to construction methods which do not involve any relations to mathematical properties of finite fields.

  10. PBW bases and KLR algebras

    CERN Document Server

    Kato, Syu

    2012-01-01

    We generalize Lusztig's geometric construction of the PBW bases of finite quantum groups of type $\\mathsf{ADE}$ under the framework of [Varagnolo-Vasserot, J. reine angew. Math. 659 (2011)]. In particular, every PBW base of such quantum groups are proven to yield a orthogonal collection in the module category of KLR-algebras. This enables us to prove Lusztig's conjecture on the positivity of the canonical (lower global) bases in terms of the (lower) PBW bases, and Kashiwara's problem on the finiteness of the global dimensions of KLR-algebras in the $\\mathsf{ADE}$ case. To achieve our goal, we develop a general formulation which guarantees nice properties of extension algebras, including a new criteria of purity of weights. (This part also applies to quiver Schur algebras.) In the appendix, we provide a proof of Shoji's conjecture on limit symbols of type $\\mathsf{B}$ [Shoji, Adv. Stud. Pure Math. 40 (2004)] based on the general formulation developed in this paper.

  11. Photography-based image generator

    Science.gov (United States)

    Dalton, Nicholas M.; Deering, Charles S.

    1989-09-01

    A two-channel Photography Based Image Generator system was developed to drive the Helmet Mounted Laser Projector at the Naval Training System Center at Orlando, Florida. This projector is a two-channel system that displays a wide field-of-view color image with a high-resolution inset to efficiently match the pilot's visual capability. The image generator is a derivative of the LTV-developed visual system installed in the A-7E Weapon System Trainer at NAS Cecil Field. The Photography Based Image Generator is based on patented LTV technology for high resolution, multi-channel, real world visual simulation. Special provisions were developed for driving the NTSC-developed and patented Helmet Mounted Laser Projector. These include a special 1023-line raster format, an electronic image blending technique, spherical lens mapping for dome projection, a special computer interface for head/eye tracking and flight parameters, special software, and a number of data bases. Good gaze angle tracking is critical to the use of the NTSC projector in a flight simulation environment. The Photography Based Image Generator provides superior dynamic response by performing a relatively simple perspective transformation on stored, high-detail photography instead of generating this detail by "brute force" computer image generation methods. With this approach, high detail can be displayed and updated at the television field rate (60 Hz).

  12. Centre-based versus home-based childcare

    NARCIS (Netherlands)

    Bauchmüller, R.

    2013-01-01

    Centre‐based childcare is seen as a public investment to facilitate maternal employment. Recent theoretical research proposes that such investments potentially lead to substantial gains in child development and thus to high returns for society as a whole. However, the empirical evidence is still sca

  13. Secure Base Priming Diminishes Conflict-Based Anger and Anxiety.

    Science.gov (United States)

    Dutton, Donald G; Lane, René A; Koren, Tamara; Bartholomew, Kim

    2016-01-01

    This study examines the impact of a visual representation of a secure base (i.e. a secure base prime) on attenuating experimentally produced anger and anxiety. Specifically, we examined the assuaging of negative emotions through exposure to an image of a mother-infant embrace or a heterosexual couple embracing. Subjects seated at a computer terminal rated their affect (Pre Affect) using the Affect Adjective Checklist (AAC) then listened to two sets of intense two person conflicts. After the first conflict exposure they rated affect again (Post 1 AAC). Following the second exposure they saw a blank screen (control condition), pictures of everyday objects (distraction condition) or a photo of two people embracing (Secure Base Prime condition). They then reported emotions using the Post 2 AAC. Compared to either control or distraction subjects, Secure Base Prime (SBP) subjects reported significantly less anger and anxiety. These results were then replicated using an internet sample with control, SBP and two new controls: Smiling Man (to control for expression of positive affect) and Cold Mother (an unsmiling mother with infant). The SBP amelioration of anger and anxiety was replicated with the internet sample. No control groups produced this effect, which was generated only by a combination of positive affect in a physically embracing dyad. The results are discussed in terms of attachment theory and research on spreading activation. PMID:27606897

  14. Optiplan: Unifying IP-based and Graph-based Planning

    CERN Document Server

    Kambhampati, S; 10.1613/jair.1698

    2011-01-01

    The Optiplan planning system is the first integer programming-based planner that successfully participated in the international planning competition. This engineering note describes the architecture of Optiplan and provides the integer programming formulation that enabled it to perform reasonably well in the competition. We also touch upon some recent developments that make integer programming encodings significantly more competitive.

  15. Photoelectrochemical based direct conversion systems

    Energy Technology Data Exchange (ETDEWEB)

    Kocha, S.; Arent, D.; Peterson, M. [National Renewable Energy Lab., Golden, CO (United States)] [and others

    1995-09-01

    The goal of this research is to develop a stable, cost effective, photoelectrochemical based system that will split water upon illumination, producing hydrogen and oxygen directly, using sunlight as the only energy input. This type of direct conversion system combines a photovoltaic material and an electrolyzer into a single monolithic device. We report on our studies of two multifunction multiphoton photoelectrochemical devices, one based on the ternary semiconductor gallium indium phosphide, (GaInP{sub 2}), and the other one based on amorphous silicon carbide. We also report on our studies of the solid state surface treatment of GaInP{sub 2} as well as our continuing effort to develop synthetic techniques for the attachment of transition metal complexes to the surface of semiconductor electrodes. All our surface studies are directed at controlling the interface energetics and forming stable catalytic surfaces.

  16. Broadcast-Based Spatial Queries

    Institute of Scientific and Technical Information of China (English)

    Kwang-Jin Park; Moon-Bae Song; Chong-Sun Hwang

    2005-01-01

    Indexing techniques have been developed for wireless data broadcast environments, in order to conserve the scarce power resources of the mobile clients. However, the use of interleaved index segments in a broadcast cycle increases the average access latency for the clients. In this paper, the broadcast-based spatial query processing methods (BBS)are presented for the location-based services. In the BBS, broadcasted data objects are sorted sequentially based on their locations, and the server broadcasts the location dependent data along with an index segment. Then, a sequential prefetching and caching scheme is designed to reduce the query response time. The performance of this scheme is investigated in relation to various environmental variables, such as the distributions of the data objects, the average speed of the clients and the size of the service area.

  17. Diversity-Based Boosting Algorithm

    Directory of Open Access Journals (Sweden)

    Jafar A. Alzubi

    2016-05-01

    Full Text Available Boosting is a well known and efficient technique for constructing a classifier ensemble. An ensemble is built incrementally by altering the distribution of training data set and forcing learners to focus on misclassification errors. In this paper, an improvement to Boosting algorithm called DivBoosting algorithm is proposed and studied. Experiments on several data sets are conducted on both Boosting and DivBoosting. The experimental results show that DivBoosting is a promising method for ensemble pruning. We believe that it has many advantages over traditional boosting method because its mechanism is not solely based on selecting the most accurate base classifiers but also based on selecting the most diverse set of classifiers.

  18. Team-based global organizations

    DEFF Research Database (Denmark)

    Zander, Lena; Butler, Christina; Mockaitis, Audra;

    2015-01-01

    challenges and opportunities of future global organizing as being team-based, we presented new advancements in the study of global teams, leadership, process and outcomes divided into four themes. Two specifically address processes in global teams: 1) the benefits of openness towards linguistic and value...... diversity in enhancing team creativity and performance, and 2) the sharing of knowledge in team-based organizations, while the other two themes address global team leadership: 3) the unprecedented significance of social capital for the success of global team leader roles; and 4) the link between shared...... leadership, satisfaction and performance in global virtual teams. We bring together ideas from the lively discussion between the audience and the panel members where we identify questions at three levels for bringing research on team-based organizing in global organizations forward: the within...

  19. Optical Fiber Grating based Sensors

    DEFF Research Database (Denmark)

    Michelsen, Susanne

    2003-01-01

    In this thesis differenct optical fiber gratings are used for sensor purposes. If a fiber with a core concentricity error (CCE) is used, a directional dependent bend sensor can be produced. The CCE direction can be determined by means of diffraction. This makes it possible to produce long......-period gratings in a fiber with a CCE direction parallel or perpendicular to the writing direction. The maximal bending sensitivity is independent on the writing direction, but the detailed bending response is different in the two cases. A temperature and strain sensor, based on a long-period grating and two...... sampled gratings, was produced and investigated. It is based on the different temperature and strain response of these gratings. Both a transfer matrix method and an overlap calculation is performed to explain the sensor response. Another type of sensor is based on tuning and modulation of a laser...

  20. Location-based Web Search

    Science.gov (United States)

    Ahlers, Dirk; Boll, Susanne

    In recent years, the relation of Web information to a physical location has gained much attention. However, Web content today often carries only an implicit relation to a location. In this chapter, we present a novel location-based search engine that automatically derives spatial context from unstructured Web resources and allows for location-based search: our focused crawler applies heuristics to crawl and analyze Web pages that have a high probability of carrying a spatial relation to a certain region or place; the location extractor identifies the actual location information from the pages; our indexer assigns a geo-context to the pages and makes them available for a later spatial Web search. We illustrate the usage of our spatial Web search for location-based applications that provide information not only right-in-time but also right-on-the-spot.

  1. Dissolution system reliability data base

    International Nuclear Information System (INIS)

    Computerized, interactive data bases are becoming increasingly important in plant operations. Reliability-centered Maintenance techniques utilize the operational history of components to identify areas where maintenance resources should be focused. The recent US Nuclear Regulatory Commission maintenance ruling requires the identification of problematic components, systems and functions, fault trending, and other related activities. There is a constant demand for the determination of root causes of failures and the documentation and tracking of the resulting corrective actions. Plant operators seek advanced methods to assist in diagnosing process upsets, planning maintenance activities, and documenting equipment warranty information. This paper describes a personal computer (PC)-based reliability data base for a nuclear fuel dissolution system as a tool for addressing these needs

  2. Brain plasticity-based therapeutics

    Science.gov (United States)

    Merzenich, Michael M.; Van Vleet, Thomas M.; Nahum, Mor

    2014-01-01

    The primary objective of this review article is to summarize how the neuroscience of brain plasticity, exploiting new findings in fundamental, integrative and cognitive neuroscience, is changing the therapeutic landscape for professional communities addressing brain-based disorders and disease. After considering the neurological bases of training-driven neuroplasticity, we shall describe how this neuroscience-guided perspective distinguishes this new approach from (a) the more-behavioral, traditional clinical strategies of professional therapy practitioners, and (b) an even more widely applied pharmaceutical treatment model for neurological and psychiatric treatment domains. With that background, we shall argue that neuroplasticity-based treatments will be an important part of future best-treatment practices in neurological and psychiatric medicine. PMID:25018719

  3. Brain Plasticity-Based Therapeutics

    Directory of Open Access Journals (Sweden)

    Michael eMerzenich

    2014-06-01

    Full Text Available The primary objective of this review article is to summarize how the neuroscience of brain plasticity, exploiting new findings in fundamental, integrative and cognitive neuroscience, is changing the therapeutic landscape for professional communities addressing brain-based disorders and disease. After considering the neurological bases of training-driven neuroplasticity, we shall describe how this neuroscience-guided perspective distinguishes this new approach from a the more-behavioral, traditional clinical strategies of professional therapy practitioners, and b an even more widely applied pharmaceutical treatment model for neurological and psychiatric treatment domains. With that background, we shall argue that neuroplasticity-based treatments will be an important part of future best-treatment practices in neurological and psychiatric medicine.

  4. Cellular-based preemption system

    Science.gov (United States)

    Bachelder, Aaron D. (Inventor)

    2011-01-01

    A cellular-based preemption system that uses existing cellular infrastructure to transmit preemption related data to allow safe passage of emergency vehicles through one or more intersections. A cellular unit in an emergency vehicle is used to generate position reports that are transmitted to the one or more intersections during an emergency response. Based on this position data, the one or more intersections calculate an estimated time of arrival (ETA) of the emergency vehicle, and transmit preemption commands to traffic signals at the intersections based on the calculated ETA. Additional techniques may be used for refining the position reports, ETA calculations, and the like. Such techniques include, without limitation, statistical preemption, map-matching, dead-reckoning, augmented navigation, and/or preemption optimization techniques, all of which are described in further detail in the above-referenced patent applications.

  5. Isotope-based quantum information

    CERN Document Server

    G Plekhanov, Vladimir

    2012-01-01

    The present book provides to the main ideas and techniques of the rapid progressing field of quantum information and quantum computation using isotope - mixed materials. It starts with an introduction to the isotope physics and then describes of the isotope - based quantum information and quantum computation. The ability to manipulate and control electron and/or nucleus spin in semiconductor devices provides a new route to expand the capabilities of inorganic semiconductor-based electronics and to design innovative devices with potential application in quantum computing. One of the major challenges towards these objectives is to develop semiconductor-based systems and architectures in which the spatial distribution of spins and their properties can be controlled. For instance, to eliminate electron spin decoherence resulting from hyperfine interaction due to nuclear spin background, isotopically controlled devices are needed (i.e., nuclear spin-depleted). In other emerging concepts, the control of the spatial...

  6. Laser-powered lunar base

    International Nuclear Information System (INIS)

    The objective was to compare a nuclear reactor-driven Sterling engine lunar base power source to a laser-to-electric converter with orbiting laser power station, each providing 1 MW of electricity to the lunar base. The comparison was made on the basis of total mass required in low-Earth-orbit for each system. This total mass includes transportation mass required to place systems in low-lunar orbit or on the lunar surface. The nuclear reactor with Sterling engines is considered the reference mission for lunar base power and is described first. The details of the laser-to-electric converter and mass are discussed. The next two solar-driven high-power laser concepts, the diode array laser or the iodine laser system, are discussed with associated masses in low-lunar-orbit. Finally, the payoff for laser-power beaming is summarized

  7. Probe-based data storage

    CERN Document Server

    Koelmans, Wabe W; Abelmann, L

    2015-01-01

    Probe-based data storage attracted many researchers from academia and industry, resulting in unprecendeted high data-density demonstrations. This topical review gives a comprehensive overview of the main contributions that led to the major accomplishments in probe-based data storage. The most investigated technologies are reviewed: topographic, phase-change, magnetic, ferroelectric and atomic and molecular storage. Also, the positioning of probes and recording media, the cantilever arrays and parallel readout of the arrays of cantilevers are discussed. This overview serves two purposes. First, it provides an overview for new researchers entering the field of probe storage, as probe storage seems to be the only way to achieve data storage at atomic densities. Secondly, there is an enormous wealth of invaluable findings that can also be applied to many other fields of nanoscale research such as probe-based nanolithography, 3D nanopatterning, solid-state memory technologies and ultrafast probe microscopy.

  8. Solar Panel based Milk Pasteurization

    DEFF Research Database (Denmark)

    Nielsen, Kirsten Mølgaard; Pedersen, Tom Søndergaard

    This paper treats the subject of analysis, design and development of the control system for a solar panel based milk pasteurization system to be used in small villages in Tanzania. The analysis deals with the demands for an acceptable pasteurization, the varying energy supply and the low cost, low...... complexity, simple user interface and high reliability demands. Based on these demands a concept for the pasteurization system is established and a control system is developed. A solar panel has been constructed and the energy absorption has been tested in Tanzania. Based on the test, the pasteurization...... system is dimensioned. A functional prototype of the pasteurization facility with a capacity of 200 l milk/hour has been developed and tested. The system is prepared for solar panels as the main energy source and is ready for a test in Tanzania....

  9. Solar Panel based Milk Pasteurization

    DEFF Research Database (Denmark)

    Nielsen, Kirsten Mølgaard; Pedersen, Tom Søndergaard

    2002-01-01

    This paper treats the subject of analysis, design and development of the control system for a solar panel based milk pasteurization system to be used in small villages in Tanzania. The analysis deals with the demands for an acceptable pasteurization, the varying energy supply and the low cost, low...... complexity, simple user interface and high reliability demands. Based on these demands a concept for the pasteurization system is established and a control system is developed. A solar panel has been constructed and the energy absorption has been tested in Tanzania. Based on the test, the pasteurization...... system is dimensioned. A functional prototype of the pasteurization facility with a capacity of 200 l milk/hour has been developed and tested. The system is prepared for solar panels as the main energy source and is ready for a test in Tanzania....

  10. Coal Reserves Data Base report

    Energy Technology Data Exchange (ETDEWEB)

    Jones, R.W.; Glass, G.B.

    1991-12-05

    The Coal Reserves Data Base (CRDB) Program is a cooperative data base development program sponsored by the Energy Information Administration (EIA). The objective of the CRDB Program is to involve knowledgeable coal resource authorities from the major coal-bearing regions in EIA's effort to update the Nation's coal reserves data. This report describes one of two prototype studies to update State-level reserve estimates. The CRDB data are intended for use in coal supply analyses and to support analyses of policy and legislative issues. They will be available to both Government and non-Government analysts. The data also will be part of the information used to supply United States energy data for international data bases and for inquiries from private industry and the public. (VC)

  11. Pareto analysis based on records

    CERN Document Server

    Doostparast, M

    2012-01-01

    Estimation of the parameters of an exponential distribution based on record data has been treated by Samaniego and Whitaker (1986) and Doostparast (2009). Recently, Doostparast and Balakrishnan (2011) obtained optimal confidence intervals as well as uniformly most powerful tests for one- and two-sided hypotheses concerning location and scale parameters based on record data from a two-parameter exponential model. In this paper, we derive optimal statistical procedures including point and interval estimation as well as most powerful tests based on record data from a two-parameter Pareto model. For illustrative purpose, a data set on annual wages of a sample production-line workers in a large industrial firm is analyzed using the proposed procedures.

  12. Steganography Based on Payload Transformation

    Directory of Open Access Journals (Sweden)

    K B Shiva Kumar

    2011-03-01

    Full Text Available Steganography is meant for covert communication of confidential data through internet. In this paper, we propose Steganography based on Payload Transformation (SPT which is non LSB and non transform domain technique where the cover image is segmented into 2*2 matrices and the matrix for payload embedding is considered based on the threshold value fixed by computing adjacent pixel intensity differences. The transformation matrix is obtained based on identity matrix and the payload bit pair. Then the stego image 2*2 matrices are derived from 2*2 cover image matrices and the transformation matrix. A key generated with first bit of payload matrix at the sending end is used to extract the payload from the stego image. It is observed that proposed algorithm is more secure and robust with reasonable PSNR in comparison with existing algorithms.

  13. HISTORY BASED PROBABILISTIC BACKOFF ALGORITHM

    Directory of Open Access Journals (Sweden)

    Narendran Rajagopalan

    2012-01-01

    Full Text Available Performance of Wireless LAN can be improved at each layer of the protocol stack with respect to energy efficiency. The Media Access Control layer is responsible for the key functions like access control and flow control. During contention, Backoff algorithm is used to gain access to the medium with minimum probability of collision. After studying different variations of back off algorithms that have been proposed, a new variant called History based Probabilistic Backoff Algorithm is proposed. Through mathematical analysis and simulation results using NS-2, it is seen that proposed History based Probabilistic Backoff algorithm performs better than Binary Exponential Backoff algorithm.

  14. Cluster identification based on correlations

    Science.gov (United States)

    Schulman, L. S.

    2012-04-01

    The problem addressed is the identification of cooperating agents based on correlations created as a result of the joint action of these and other agents. A systematic method for using correlations beyond second moments is developed. The technique is applied to a didactic example, the identification of alphabet letters based on correlations among the pixels used in an image of the letter. As in this example, agents can belong to more than one cluster. Moreover, the identification scheme does not require that the patterns be known ahead of time.

  15. Model-based requirements engineering

    CERN Document Server

    Holt, Jon

    2012-01-01

    This book provides a hands-on introduction to model-based requirementsengineering and management by describing a set of views that form the basisfor the approach. These views take into account each individual requirement interms of its description, but then also provide each requirement with meaning byputting it into the correct 'context'. A requirement that has been put into a contextis known as a 'use case' and may be based upon either stakeholders or levelsof hierarchy in a system. Each use case must then be analysed and validated bydefining a combination of scenarios and formal mathematica

  16. Gold based bulk metallic glass

    OpenAIRE

    Schroers, Jan; Lohwongwatana, Boonrat; Johnson, William L.; Peker, Atakan

    2005-01-01

    Gold-based bulk metallic glass alloys based on Au-Cu-Si are introduced. The alloys exhibit a gold content comparable to 18-karat gold. They show very low liquidus temperature, large supercooled liquid region, and good processibility. The maximum casting thickness exceeds 5 mm in the best glassformer. Au49Ag5.5Pd2.3Cu26.9Si16.3 has a liquidus temperature of 644 K, a glass transition temperature of 401 K, and a supercooled liquid region of 58 K. The Vickers hardness of the alloys in this system...

  17. Why Internet-based Education?

    Directory of Open Access Journals (Sweden)

    Morton Ann Gernsbacher

    2015-01-01

    Full Text Available This essay illustrates five ways that Internet-based higher education can capitalize on fundamental principles of learning. Internet-based education can enable better mastery through distributed (shorter, more frequent practice rather than massed (longer, less frequent practice; it can optimize performance because it allows students to learn at their peak time of their day; it can deepen memory because it requires cheat-proof assignments and tests; it can promote critical thinking because it necessitates intellectual winnowing and sifting; and it can enhance writing skills by requiring students to write frequently and for a broad audience.

  18. Laser-based coatings removal

    Energy Technology Data Exchange (ETDEWEB)

    Freiwald, J.G.; Freiwald, D.A. [F2 Associates, Inc., Albuquerque, NM (United States)

    1995-10-01

    Over the years as building and equipment surfaces became contaminated with low levels of uranium or plutonium dust, coats of paint were applied to stabilize the contaminants in place. Most of the earlier paint used was lead-based paint. More recently, various non-lead-based paints, such as two-part epoxy, are used. For D&D (decontamination and decommissioning), it is desirable to remove the paints or other coatings rather than having to tear down and dispose of the entire building. This report describes the use of pulse-repetetion laser systems for the removal of paints and coatings.

  19. Knowledge-based nursing diagnosis

    Science.gov (United States)

    Roy, Claudette; Hay, D. Robert

    1991-03-01

    Nursing diagnosis is an integral part of the nursing process and determines the interventions leading to outcomes for which the nurse is accountable. Diagnoses under the time constraints of modern nursing can benefit from a computer assist. A knowledge-based engineering approach was developed to address these problems. A number of problems were addressed during system design to make the system practical extended beyond capture of knowledge. The issues involved in implementing a professional knowledge base in a clinical setting are discussed. System functions, structure, interfaces, health care environment, and terminology and taxonomy are discussed. An integrated system concept from assessment through intervention and evaluation is outlined.

  20. Behavior-based evacuation planning

    KAUST Repository

    Rodriguez, Samuel

    2010-05-01

    In this work, we present a formulation of an evacuation planning problem that is inspired by motion planning and describe an integrated behavioral agent-based and roadmap-based motion planning approach to solve it. Our formulation allows users to test the effect on evacuation of a number of different environmental factors. One of our main focuses is to provide a mechanism to investigate how the interaction between agents influences the resulting evacuation plans. Specifically, we explore how various types of control provided by a set of directing agents effects the overall evacuation planning strategies of the evacuating agents. ©2010 IEEE.

  1. Construction of UHVAC Test Base

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The construction of the UHVAC test base of SGCC is an important component of the pilot project on UHVAC power transmission and transformation in China. This paper introduces the layout, technical requirements and main test functions of the UHVAC test base as well as difficulties during construction. It lays stress on the characterization of a 1 000-kV single-circuit test line, a 1 000-kV one-tower double-circuit test line, a full voltage test site for UHV equipment, a climate laboratory, a corona cage and a...

  2. Bases de dades, febrer 2007

    OpenAIRE

    Camps Paré, Rafael; Casillas Santillán, Luis Alberto; Costal Costa, Dolors; Gibert Ginestà, Marc; Martín Escofet, Carme; Pérez Mora, Óscar

    2007-01-01

    Les bases de dades són el mètode preferit per a l'emmagatzemament estructurat de dades. Les grans aplicacions multiusuari, els telèfons mòbils o les agendes electròniques utilitzen tecnologia de bases de dades per a assegurar la integritat de les dades i facilitar la tasca tant dels usuaris com dels programadors que les van desenvolupar. Des de la realització del primer model de dades, passant per l'administració del sistema gestor, fins a arribar al desenvolupament de l'aplicació, la tecn...

  3. Bases de datos, febrero 2007

    OpenAIRE

    Camps Paré, Rafael; Casillas Santillán, Luis Alberto; Costal Costa, Dolors; Gibert Ginestà, Marc; Martín Escofet, Carme; Pérez Mora, Óscar

    2009-01-01

    Les bases de dades són el mètode preferit per a l'emmagatzemament estructurat de dades. Les grans aplicacions multiusuari, els telèfons mòbils o les agendes electròniques utilitzen tecnologia de bases de dades per a assegurar la integritat de les dades i facilitar la tasca tant dels usuaris com dels programadors que les van desenvolupar. Des de la realització del primer model de dades, passant per l'administració del sistema gestor, fins a arribar al desenvolupament de l'aplicació, la tecn...

  4. Attribute-Based Data Sharing

    Directory of Open Access Journals (Sweden)

    Ms. Rahila Fatima

    2014-12-01

    Full Text Available Messages addressed to specific users can be decrypted by Key Generation Centre (KGC by generating their private keys. Data owner wants the data to be delivered only to specified user and not to unauthorized person that is the data owner makes their private data accessible only to authorized person. We propose attribute based encryption and escrow problem which means written agreement delivered to a third party to overcome this problem. Attribute based Encryption (ABE is a type of public-key encryption in which the private key of a user and the cipher text are dependent upon attributes. It is a promising cryptographic approach.

  5. Inquiry-based science education

    DEFF Research Database (Denmark)

    Østergaard, Lars Domino; Sillasen, Martin Krabbe; Hagelskjær, Jens;

    2010-01-01

    Inquiry-based science education (IBSE) er en internationalt afprøvet naturfagsdidaktisk metode der har til formål at øge elevernes interesse for og udbytte af naturfag. I artiklen redegøres der for metoden, der kan betegnes som en elevstyret problem- og undersøgelsesbaseret naturfagsundervisnings......Inquiry-based science education (IBSE) er en internationalt afprøvet naturfagsdidaktisk metode der har til formål at øge elevernes interesse for og udbytte af naturfag. I artiklen redegøres der for metoden, der kan betegnes som en elevstyret problem- og undersøgelsesbaseret...

  6. Why internet-based education?

    Science.gov (United States)

    Gernsbacher, Morton Ann

    2014-01-01

    This essay illustrates five ways that Internet-based higher education can capitalize on fundamental principles of learning. Internet-based education can enable better mastery through distributed (shorter, more frequent) practice rather than massed (longer, less frequent) practice; it can optimize performance because it allows students to learn at their peak time of their day; it can deepen memory because it requires cheat-proof assignments and tests; it can promote critical thinking because it necessitates intellectual winnowing and sifting; and it can enhance writing skills by requiring students to write frequently and for a broad audience. PMID:25653625

  7. Projects-based Language Training

    OpenAIRE

    Marina Y. Vaslyayeva; Dinara R. Ahmetova; Natalya A. Svich

    2014-01-01

    The article deals with the importance of appliance of project-based method during the language learning process. The key thing is that the appliance of project-based method during the language training helps to concentrate the learner’s attention on the issue itself, but not on the language structure, to go right into the core of the issue, to address the problems, using the language as a tool. The article uncovers the core of this method: students rethink new facts and ideas by themselve...

  8. Laser-based coatings removal

    International Nuclear Information System (INIS)

    Over the years as building and equipment surfaces became contaminated with low levels of uranium or plutonium dust, coats of paint were applied to stabilize the contaminants in place. Most of the earlier paint used was lead-based paint. More recently, various non-lead-based paints, such as two-part epoxy, are used. For D ampersand D (decontamination and decommissioning), it is desirable to remove the paints or other coatings rather than having to tear down and dispose of the entire building

  9. Ontology-based application integration

    CERN Document Server

    Paulheim, Heiko

    2011-01-01

    Ontology-based Application Integration introduces UI-level (User Interface Level) application integration and discusses current problems which can be remedied by using ontologies. It shows a novel approach for applying ontologies in system integration. While ontologies have been used for integration of IT systems on the database and on the business logic layer, integration on the user interface layer is a novel field of research. This book also discusses how end users, not only developers, can benefit from semantic technologies. Ontology-based Application Integration presents the development o

  10. Transistor-based interface circuitry

    Science.gov (United States)

    Taubman, Matthew S.

    2007-02-13

    Among the embodiments of the present invention is an apparatus that includes a transistor, a servo device, and a current source. The servo device is operable to provide a common base mode of operation of the transistor by maintaining an approximately constant voltage level at the transistor base. The current source is operable to provide a bias current to the transistor. A first device provides an input signal to an electrical node positioned between the emitter of the transistor and the current source. A second device receives an output signal from the collector of the transistor.

  11. Case-based medical informatics

    Directory of Open Access Journals (Sweden)

    Arocha José F

    2004-11-01

    Full Text Available Abstract Background The "applied" nature distinguishes applied sciences from theoretical sciences. To emphasize this distinction, we begin with a general, meta-level overview of the scientific endeavor. We introduce the knowledge spectrum and four interconnected modalities of knowledge. In addition to the traditional differentiation between implicit and explicit knowledge we outline the concepts of general and individual knowledge. We connect general knowledge with the "frame problem," a fundamental issue of artificial intelligence, and individual knowledge with another important paradigm of artificial intelligence, case-based reasoning, a method of individual knowledge processing that aims at solving new problems based on the solutions to similar past problems. We outline the fundamental differences between Medical Informatics and theoretical sciences and propose that Medical Informatics research should advance individual knowledge processing (case-based reasoning and that natural language processing research is an important step towards this goal that may have ethical implications for patient-centered health medicine. Discussion We focus on fundamental aspects of decision-making, which connect human expertise with individual knowledge processing. We continue with a knowledge spectrum perspective on biomedical knowledge and conclude that case-based reasoning is the paradigm that can advance towards personalized healthcare and that can enable the education of patients and providers. We center the discussion on formal methods of knowledge representation around the frame problem. We propose a context-dependent view on the notion of "meaning" and advocate the need for case-based reasoning research and natural language processing. In the context of memory based knowledge processing, pattern recognition, comparison and analogy-making, we conclude that while humans seem to naturally support the case-based reasoning paradigm (memory of past experiences

  12. Flexible graphene based microwave attenuators.

    Science.gov (United States)

    Byun, Kisik; Ju Park, Yong; Ahn, Jong-Hyun; Min, Byung-Wook

    2015-02-01

    We demonstrate flexible 3 dB and 6 dB microwave attenuators using multilayer graphene grown by the chemical vapor deposition method. On the basis of the characterized results of multilayer graphene and graphene-Au ohmic contacts, the graphene attenuators are designed and measured. The flexible graphene-based attenuators have 3 dB and 6 dB attenuation with a return loss of less than -15 dB at higher than 5 GHz. The devices have shown durability in a bending cycling test of 100 times. The circuit model of the attenuator based on the characterized results matches the experimental results well. PMID:25590144

  13. Flexible graphene based microwave attenuators

    International Nuclear Information System (INIS)

    We demonstrate flexible 3 dB and 6 dB microwave attenuators using multilayer graphene grown by the chemical vapor deposition method. On the basis of the characterized results of multilayer graphene and graphene–Au ohmic contacts, the graphene attenuators are designed and measured. The flexible graphene-based attenuators have 3 dB and 6 dB attenuation with a return loss of less than −15 dB at higher than 5 GHz. The devices have shown durability in a bending cycling test of 100 times. The circuit model of the attenuator based on the characterized results matches the experimental results well. (paper)

  14. ELMO Bumpy Torus data base

    International Nuclear Information System (INIS)

    This document describes a set of computer programs developed to facilitate storage and retrieval of data generated by the ELMO Bumpy Torus (EBT) experiment. The data is stored in a collection of files which contain either raw or analyzed data from diagnostics connected to the experiment. An on-line index of steady-state machine conditions, diagnostic or analysis status information, and raw or analyzed data values unifies the file collection into a data base. The index is implemented under the System 1022 data base management system

  15. Technology base for microgravity horticulture

    Science.gov (United States)

    Sauer, R. L.; Magnuson, J. W.; Scruby, R. R.; Scheld, H. W.

    1987-01-01

    Advanced microgravity plant biology research and life support system development for the spacecraft environment are critically hampered by the lack of a technology base. This inadequacy stems primarily from the fact that microgravity results in a lack of convective currents and phase separation as compared to the one gravity environment. A program plan is being initiated to develop this technology base. This program will provide an iterative flight development effort that will be closely integrated with both basic science investigations and advanced life support system development efforts incorporating biological processes. The critical considerations include optimum illumination methods, root aeration, root and shoot support, and heat rejection and gas exchange in the plant canopy.

  16. Metamaterial metal-based bolometers

    OpenAIRE

    Niesler, Fabian B. P.; Gansel, Justyna K.; Fischbach, Sarah; Wegener, Martin

    2012-01-01

    We demonstrate metamaterial metal-based bolometers, which take advantage of resonant absorption in that a spectral and/or polarization filter can be built into the bolometer. Our proof-of-principle gold-nanostructure-based devices operate around 1.5 \\mum wavelength and exhibit room-temperature time constants of about 134 \\mus. The ultimate detectivity is limited by Johnson noise, enabling room-temperature detection of 1 nW light levels within 1 Hz bandwidth. Graded bolometer arrays might allo...

  17. Service-based dominant logic

    OpenAIRE

    Neganova, Irina

    2014-01-01

    Purpose: to investigate a concept of service-based dominant logic, define it, reveal its dimensions, theoretical framework, and managerial implications. Design/methodology/approach: the topic is approached by theoretical analysis and conceptual development. Using a definition of the dominant logic as a mind set or a world view the present article suggests ‘service-based dominant logic’ as a name for a generic theoretical concept instead of the widely used ‘service-dominant logic’ whic...

  18. Study on synthesizing aminated lignin-based polyurethane adhesives%胺化改性木质素合成聚氨酯胶粘剂的研究

    Institute of Scientific and Technical Information of China (English)

    王婧; 赵殊; 吴宁; 黄竹君

    2012-01-01

    采用Mannich法对纯化木质素进行胺化改性,以提高其活泼氢数量和木质素的反应活性;然后以此作为部分聚乙二醇的替代物,将其与异氰酸酯反应合成PU(聚氨酯)胶粘剂.结果表明:胺化木质素中引入的氮含量约为2.64%,说明木质素的活性明显提高;当w(胺化木质素)=25%时,相应PU胶粘剂的湿胶接强度( 1.53 MPa)达到GB/T 9846-2004标准中Ⅰ类胶合板的指标要求,并且其热稳定性能得以明显提高;胺化木质素可以取代部分聚乙二醇,其含量对胶粘剂的力学性能和热稳定性能影响显著.%In order lo improve active hydrogen number and reactivity of lignin,an aminated lignin,which purification lignin was modified by amine,was made by Mannich method. Then a PU(polyurethane) adhesive was synthesized by reaction between aminated lignin as part substitute of polyethylene glycol and isocyanate. The results showed that the lignin activity was obviously increased because nitrogen content introduced into aminated lignin was about 2.64%. The wet bonding strength(1.53 Mpa) of the corresponding PU adhesive could meet index requirement of plywood-I class in GB/T 9846-2004 standard, and its thermal stability was obviously improved when mass fraction of aminated lignin was 25%. The aminated lignin could replace part polyethylene glycol,and the influences of aminated lignin contents on mechanical properties and thermal stability for adhesives were prominent.

  19. RF MEMS Based Reconfigurable Antennas

    Science.gov (United States)

    Simons, Rainee N.

    2004-01-01

    The presentation will first of all address the advantages of RF MEMS circuit in antenna applications and also the need for electronically reconfigurable antennas. Next, discuss some of the recent examples of RF MEMS based reconfigurable microstrip antennas. Finally, conclude the talk with a summary of MEMS antenna performance.

  20. Wavelet-Based Volume Visualization

    NARCIS (Netherlands)

    Roerdink, Jos B.T.M.; Westenberg, Michel A.

    1999-01-01

    We consider multiresolution visualization of large volume data sets based on wavelets. Starting from a wavelet decomposition of the data, a low resolution image is computed; this approximation can be successively refined. The practical need for such a multiresolution approach is motivated. The mathe

  1. The LADM based on INTERLIS

    NARCIS (Netherlands)

    Germann, M.; Kaufmann, J.; Lemmen, C.H.J.; Van Oosterom, P.J.M.; De Zeeuw, K.

    2015-01-01

    Both the conceptual schema language INTERLIS and the land administration domain model (LADM) share the same model driven architecture (MDA) principles. In this paper we explore how INTERLIS and LADM complement each other in actual implementation of land administration system based on the LADM using

  2. Graph-based Image Inpainting

    OpenAIRE

    Defferrard, Michaël

    2014-01-01

    The project goal was to explore the applications of spectral graph theory to address the inpainting problem of large missing chunks. We used a non-local patch graph representation of the image and proposed a structure detector which leverages the graph representation and influences the fill-order of our exemplar-based algorithm. Our method achieved state-of-the-art performances.

  3. Exercise Based- Pain Relief Program

    DEFF Research Database (Denmark)

    Zadeh, Mahdi Hossein

    Exercise-based pain management programs are suggested for relieving from musculoskeletal pain; however the pain experienced after unaccustomed, especially eccentric exercise (ECC) alters people´s ability to participate in therapeutic exercises. Subsequent muscle pain after ECC has been shown to...

  4. Activity based costing (ABC Method

    Directory of Open Access Journals (Sweden)

    Prof. Ph.D. Saveta Tudorache

    2008-05-01

    Full Text Available In the present paper the need and advantages are presented of using the Activity BasedCosting method, need arising from the need of solving the information pertinence issue. This issue has occurreddue to the limitation of classic methods in this field, limitation also reflected by the disadvantages ofsuch classic methods in establishing complete costs.

  5. Graphite-based photovoltaic cells

    Science.gov (United States)

    Lagally, Max; Liu, Feng

    2010-12-28

    The present invention uses lithographically patterned graphite stacks as the basic building elements of an efficient and economical photovoltaic cell. The basic design of the graphite-based photovoltaic cells includes a plurality of spatially separated graphite stacks, each comprising a plurality of vertically stacked, semiconducting graphene sheets (carbon nanoribbons) bridging electrically conductive contacts.

  6. Intelligence-based systems engineering

    CERN Document Server

    Tolk, Andreas

    2011-01-01

    The International Council on Systems Engineering (INCOSE) defines Systems Engineering as an interdisciplinary approach and means to enable the realization of successful systems. Researchers are using intelligence-based techniques to support the practices of systems engineering in an innovative way. This research volume includes a selection of contributions by subject experts to design better systems.

  7. Computer-Based Career Interventions.

    Science.gov (United States)

    Mau, Wei-Cheng

    The possible utilities and limitations of computer-assisted career guidance systems (CACG) have been widely discussed although the effectiveness of CACG has not been systematically considered. This paper investigates the effectiveness of a theory-based CACG program, integrating Sequential Elimination and Expected Utility strategies. Three types of…

  8. DNA-based human karyotype

    Energy Technology Data Exchange (ETDEWEB)

    Mayall, B.H.; Carrano, A.V.; Moore, C.H. II; Ashworth, L.K.; Bennett, D.E.; Mendelsohn, M.L.

    1984-01-01

    Image cytometry and computer analysis are used to determine the relative DNA content and the DNA-based centromeric index of the 24 chromosomes of the human karyotype. A two-step procedure is used. Chromosomes of cells in metaphase first are stained with quinacrine and identified visually by their fluorescent Q-band patterns. They then are stained for DNA using gallocyanin-chrome alum. The chromosome images are scanned and recorded as digital values of optical density by an CYDAC image cytometric microscope system, CYDAC. The digital images are processed by computer to measure for each chromosome the relative DNA stain contents of the whole chromosome and of the p and q arms and the DNA-based centromeric index. About ten cells are analyzed for each of the donors, who are phenotypically normal men and women. The chromosome measurements are pooled by chromosome type for each donor and are compared among donors. The means of the chromosome measurements give the DNA-based human karyotype. Analysis of the DNA-based data shows that some chromosomes or portions of chromosomes vary significantly among donors. These variants do not correlate with detectable morphologic polymorphisms, such as Q- or C-band variants; thus they represent new and otherwise undetectable chromosome polymorphisms whose genetic basis and clinical significance are yet to be determined. 54 references, 1 figure, 3 tables.

  9. Beyond Nation-Based Frameworks

    DEFF Research Database (Denmark)

    Ørum, Tania

    In his study of Robert Rauschenberg and the Global Rise of American Art (Ikegami, The Great Migrator, 2010) Hiroko Ikegami argues that ”it is necessary to go beyond the nation-based framework” and ”beyond the binary of the global and the local” and look at postwar art ”in a wider, transnational and...

  10. MTA Computer Based Evaluation System.

    Science.gov (United States)

    Brenner, Lisa P.; And Others

    The MTA PLATO-based evaluation system, which has been implemented by a consortium of schools of medical technology, is designed to be general-purpose, modular, data-driven, and interactive, and to accommodate other national and local item banks. The system provides a comprehensive interactive item-banking system in conjunction with online student…

  11. Problem Based Learning in Metaverse

    Science.gov (United States)

    Barry, Dana M.; Kanematsu, Hideyuki; Fukumura, Yoshimi

    2010-01-01

    Problem Based Learning (PBL) is a powerful tool for both science and engineering education in the real world. Therefore, Japanese educators/researchers (with assistance from a US educator) carried out a pilot study to determine the effectiveness of using PBL activities in Metaverse. Their project was carried out by student teams from the US and…

  12. CCL8 BASED IMMUNOLOGICAL MONITORING

    DEFF Research Database (Denmark)

    The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of CCL8.The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other...

  13. Platform-based production development

    DEFF Research Database (Denmark)

    Bossen, Jacob; Brunoe, Thomas Ditlev; Nielsen, Kjeld

    2015-01-01

    Platforms as a means for applying modular thinking in product development is relatively well studied, but platforms in the production system has until now not been given much attention. With the emerging concept of platform-based co-development the importance of production platforms is though...

  14. Sinc-function based Network

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    1998-01-01

    The purpose of this paper is to describe a neural network (SNN), that is based on Shannons ideas of reconstruction of a real continuous function from its samples. The basic function, used in this network, is the Sinc-function. Two learning algorithms are described. A simple one called IM...

  15. Sinc-function based Network

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    1999-01-01

    The purpose of this paper is to describe a neural network (SNN), that is based on Shannons ideas of reconstruction of a real continuous function from its samples. The basic function, used in this network, is the Sinc-function. Two learning algorithms are described. A simple one called IM...

  16. ERB - Graphic knowledge base editor

    International Nuclear Information System (INIS)

    The paper describes the present state and future prospects of the Expert System for Operator Support (ESOS) developed at the Nuclear Research Institute at Rez near Prague (NRI). Special emphasis is put on knowledge acquisition and knowledge base representation means - ERB. ERB is a package of programs, which enables the user to create, edit and compile a knowledge base of the Expert System RECON, to create and edit testing data and to test knowledge base (KB). The knowledge base is displayed in the form of a graph, where nodes represent the rules and arcs represent the relations ''PREDECESSOR→SUCCESSOR''. The filling of KB is integrated with the design of their graphical representation. Owing to this, the form of the KB representation makes the whole KB more understandable. The filling process of KB corresponds with general methodologies, where in the first step nodes with identifiers and texts are defined, in the second step relations between them are specified, in the third step the predecessor is defined and finally, relations between nodes are concretized. The paper contains a description of the functions offered by the ERB. (author). 2 refs, 5 figs

  17. Interactive example-based hatching

    NARCIS (Netherlands)

    Gerl, Moritz; Isenberg, Tobias

    2013-01-01

    We present an approach for interactively generating pen-and-ink hatching renderings based on hand-drawn examples. We aim to overcome the regular and synthetic appearance of the results of existing methods by incorporating human virtuosity and illustration skills in the computer generation of such im

  18. SILAC-Based Temporal Phosphoproteomics

    DEFF Research Database (Denmark)

    Francavilla, Chiara; Hekmat, Omid; Blagoev, Blagoy;

    2014-01-01

    signaling events. Here we provide an optimized SILAC-based proteomic workflow to analyze temporal changes in phosphoproteomes, which involve a generic three step enrichment protocol for phosphopeptides. SILAC-labeled peptides from digested whole cell lysates are as a first step enriched for phosphorylated...

  19. The Base of the Pyramid

    NARCIS (Netherlands)

    Hutte, E.; Vermeulen, P.A.M.

    2014-01-01

    This chapter provides a brief background to the Base of the Pyramid (BoP) phenomenon. It begins with a discussion on what sets the BoP markets apart from more traditional markets and why companies have not identified them as a business opportunity. The chapter then provides an overview of how attent

  20. DNA-based hybrid catalysis

    NARCIS (Netherlands)

    Rioz-Martínez, Ana; Roelfes, Gerard

    2015-01-01

    In the past decade, DNA-based hybrid catalysis has merged as a promising novel approach to homogeneous (asymmetric) catalysis. A DNA hybrid catalysts comprises a transition metal complex that is covalently or supramolecularly bound to DNA. The chiral microenvironment and the second coordination sphe