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Sample records for ames test

  1. Estimation of γ irradiation induced genetic damage by Ames test

    International Nuclear Information System (INIS)

    Hosoda, Eiko

    1999-01-01

    Mutation by 60 Co γ irradiation was studied in five different histidine-requiring auxotrophs of Salmonella typhimurium. The strains TA98 (sensitive to frameshift) and TA100 (sensitive to base-pair substitution) were irradiated (10-84 Gy and 45-317 Gy, respectively) and revertants were counted. TA98 exhibited radiation-induced revertants, 2.8 fold of spontaneous revertants, although no significant increase was detected in TA100. Then, three other frameshift-sensitive strains TA1537, TA1538 and TA94 were irradiated in a dose of 61-167 Gy. Only in TA94, revertants increased 3.5 fold. Since spontaneous revertants are known to be independent of cell density, a decrease of bacterial number by γ irradiation was confirmed not to affect the induced revertants by dilution test. Thus the standard Ames Salmonella assay identified γ irradiation was confirmed not to affect the induced revertants by dilution test. Thus the standard Ames Salmonella assay identified γ irradiation as a mutagenetic agent. The mutagenicity of dinitropyrene, a mutagen widely existing in food, and dismutagenicity of boiling water insoluble fraction of Hizikia fusiforme, edible marine alga, were tested on γ induced revertant formation in TA98 and TA94. Dinitropyrene synergistically increased γ induced revertants and Hizikia insoluble fraction reduced the synergistic effect of dinitropyrene dependently on the concentration. (author)

  2. Mutagenicity of Flavonoids Assayed by Bacterial Reverse Mutation (Ames Test

    Directory of Open Access Journals (Sweden)

    Eliana Aparecida Varanda

    2012-05-01

    Full Text Available The mutagenicity of ten flavonoids was assayed by the Ames test, in Salmonella typhimurium strains TA98, TA100 and TA102, with the aim of establishing hydroxylation pattern-mutagenicity relationship profiles. The compounds assessed were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In the Ames assay, quercetin acted directly and its mutagenicity increased with metabolic activation. In the presence of S9 mix, kaempferol and galangin were mutagenic in the TA98 strain and kaempferol showed signs of mutagenicity in the other strains. The absence of hydroxyl groups, as in flavone, only signs of mutagenicity were shown in strain TA102, after metabolization and, among monohydroxylated flavones (3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone, the presence of hydroxyl groups only resulted in minor changes. Luteolin and fisetin also showed signs of mutagenicity in strain TA102. Finally, chrysin, which has only two hydroxy groups, at the 5-OH and 7-OH positions, also did not induce mutagenic activity in any of the bacterial strains used, under either activation condition. All the flavonoids were tested at concentrations varying from 2.6 to 30.7 nmol/plate for galangin and 12.1 to 225.0 nmol/plate for other flavonoids. In light of the above, it is necessary to clarify the conditions and the mechanisms that mediate the biological effects of flavonoids before treating them as therapeutical agents, since some compounds can be biotransformed into more genotoxic products; as is the case for galangin, kaempferol and quercetin.

  3. Identification of Radiation Effects on Carcinogenic Food Estimated by Ames Test

    International Nuclear Information System (INIS)

    Afifi, M.; Eid, I.; El - Nagdy, M.; Zaher, R.; Abd El-Karem, H.; Abd EL Karim, A.

    2016-01-01

    A major concern in studies related to carcinogenesis is the exposure to the exogenous carcinogens that may occur in food in both natural and polluted human environments. The purpose of the present study is to examine some of food products by Ames test to find out if food products carcinogenic then expose food to gamma radiation to find out the effect of radiation on it as a treatment. In this study, the food samples were examined by Ames test (Salmonella typhimurium mutagenicity test) to find out that a food product could be carcinogenic or highly mutated. Testing of chemicals for mutagenicity is based on the knowledge that a substance which is mutagenic in the bacterium is more likely than not to be a carcinogen in laboratory animals, and thus , by extension, present a risk of cancer to humans. After that food products that showed mutagenicity exposed to gamma radiation at different doses to examine the effect of gamma radiation on food products. This study represent γ radiation effect on carcinogenic food by using Ames test in the following steps: Detect food by Ames test using Salmonella typhimurium strains in which the colony count /plate for each food sample will show if food is slightly mutated or highly mutated or carcinogenic. If food is highly mutated or carcinogenic with high number of colonies /plate, then the carcinogenic food or highly mutated food exposed to different doses of radiation The applied doses in this study were 0, 2.5, 5, and 10 (KGy). Detect the radiation effect on food samples by Ames test after irradiation. The study shows that mutated and carcinogenic food products estimated by Ames test could be treated by irradiation

  4. Resolution of contradiction between in silico predictions and Ames test results for four pharmaceutically relevant impurities.

    Science.gov (United States)

    Gunther, William C; Kenyon, Michelle O; Cheung, Jennifer R; Dugger, Robert W; Dobo, Krista L

    2017-12-01

    The ICH M7 Guideline requires low level control of mutagenic impurities in pharmaceutical products to minimize cancer risk in patients (ICHM7, 2014). Bacterial mutagenicity (Ames) data is generally used to determine mutagenic and possible carcinogenic potential of compounds. Recently, a publication on experiences of using two in silico systems to identify potentially mutagenic impurities highlighted the importance of performing a critical review of published Ames data utilized as part of a mutagenicity assessment of impurities (Greene et al., 2015). Four compounds (2-amino-5-hydroxybenzoic acid, 2-amino-3-chlorobenzoic acid, methyl 2-amino-4-chlorobenzoate and 4-morpholinopyridine) reported mutagenic were identified in a two system in silico assessment and expert review of the structuresas non-mutagenic. Likely reasons for mutagenicity could not be identified and the purity of the compounds tested was proposed. In the current investigation, the purest available sample of the four compounds was tested in an OECD-compliant Ames test. The compounds were all found to be non-mutagenic. Possible reasons for the discrepancy between previously reported and current results are discussed. Additionally, important points to consider when conducting an expert review of available Ames data are provided particularly in cases where reported Ames results are discrepant with a two system in silico assessment. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Assaying the Mutagenic Potential of ELF Radiation through Reverse Mutagenesis via the Ames Test

    National Research Council Canada - National Science Library

    Moga, Paul

    1996-01-01

    ...) on certain strains of Salmonella typhimurium. The strain of S-typhimurium used in the Ames test has a mutation on one gene of the histidine operon which prevents it from growing and replicating without the presence of histidine in the media...

  6. Mutagenic and antimutagenic activities of bioflavonoids and structural analogues in the Ames/Salmonella test

    NARCIS (Netherlands)

    Mohn GR; Van der Stel JJ; Stavenuiter JFC; Hamzink MRJ; Kreijl CF; LEO; LBO

    1996-01-01

    The mutagenic and antimutagenic properties of bioflavonoids were determined in the bacterial mutagenicity test of Ames, using Salmonella typhimurium strains TA98 and TA100. The decreasing order of mutagenic activity found in both strains was quercetin>myricetin-kaempferol>morin hydrate. The

  7. Use of the modified Ames test as an indicator of the carcinogenicity of residual aromatic extracts

    Energy Technology Data Exchange (ETDEWEB)

    Boogaard, P.; Hedelin, A.; Riley, A.; Rushton, E.; Vaissiere, M.; Minsavage, G.; Rohde, A.; Dalbey, W.

    2013-01-15

    Existing data demonstrate that residual aromatic extracts (RAEs) can be either carcinogenic or non-carcinogenic. CONCAWE had previously concluded that 'Although limited data available indicate that some RAEs are weakly carcinogenic, it is not possible to provide a general recommendation. Classify on a case-by-case basis' (CONCAWE 2005). Therefore CONCAWE's Health/Toxicology Subgroup (H/TSG) has developed a proposal for the use of the modified Ames test as a short-term predictive screening tool for decisions on the classification of RAEs for carcinogenicity. The relationship between RAE chemistry and carcinogenic potential is not as well understood as it is for some other categories of substances, e.g. Other Lubricant Base Oils (OLBO). However, a correlation has been found between the results of the skin carcinogenicity bioassay and the mutagenicity index (MI) obtained from the modified Ames test. Data supporting this correlation are summarised in this report. The H/TSG confirmed that the modified Ames test can be used as a predictive screening tool and that a cut-off value can be established to make a distinction between carcinogenic and non-carcinogenic products. RAEs with a MI > 0.4 demonstrated carcinogenic potential upon dermal application to mouse skin with chronic exposure. RAEs with a MI > 0.4 did not demonstrate a carcinogenic potential. To justify the use of the modified Ames test with RAEs, additional analysis of the repeatability of the test with RAEs was required. With this objective, CONCAWE sponsored a round robin study with different samples of RAEs from member companies, at three different laboratories. The repeatability demonstrated in the round robin study with RAEs support the proposed use of the modified Ames test. As part of the tools available for use by member companies, the H/TSG proposed a standard operating procedure (SOP) (included as an Appendix to this report) on the conduct of the modified Ames test with RAEs. The H

  8. Are effects of common ragwort in the Ames test caused by pyrrolizidine alkaloids?

    Science.gov (United States)

    Bovee, Toine F H; Helsdingen, Richard J R; Hoogenboom, Ron L A P; de Nijs, Monique W C M; Liu, Xiaojie; Vrieling, Klaas; Klinkhamer, Peter G L; Peijnenburg, Ad A C M; Mulder, Patrick P J

    2015-08-01

    It has previously been demonstrated by others that acetone extracts of Senecio jacobaea (syn. Jacobaea vulgaris, common or tansy ragwort) test positive in the Salmonella/microsome mutagenicity test (Ames test). Pyrrolizidine alkaloids (PAs) are thought to be responsible for these mutagenic effects. However, it was also observed that the major PA present in common ragwort, jacobine, produced a negative response (with and without the addition of rat liver S9) in Salmonella test strains TA98, TA100, TA1535 and TA1537. To investigate which compounds in the plant extracts were responsible for the positive outcome, the present study investigated the contents and mutagenic effects of methanol and acetone extracts prepared from dried ground S. jacobaea and Senecio inaequidens (narrow-leafed ragwort). Subsequently, a fractionation approach was set up in combination with LC-MS/MS analysis of the fractions. It was shown that the positive Ames test outcomes of S. jacobaea extracts are unlikely to be caused by PAs, but rather by the flavonoid quercetin. This study also demonstrates the importance of identifying compounds responsible for positive test results in bioassays. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Application of the Ames mutagenicity test to food processed by physical preservation methods

    International Nuclear Information System (INIS)

    Kooij, J.G. van; Leveling, H.B.; Schubert, J.

    1978-01-01

    An irradiated (380 krad) mixture of four fresh vegetables - leek, celery, carrot, and cauliflower - was examined for mutagenicity by the Ames mutagenicity test using four different histidine-deficient strains of Salmonellae. Water extracts were prepared from the irradiated and unirradiated vegetables - a freeze dried extract (FDE) and a boiled extract (BE). Several problems were overcome in the mutagenicity testing of a complex substance such as food which contains free histidine, different species of bacteria, and a mixture of low and high molecular weight chemicals. In addition, we eliminated an omission in the usual protocols of the Ames test by testing the positive mutagen controls in the presence and absence of the test samples, thus reducing the possible incidence of false negatives and false positives. The induction and expression of mutagenesis by sodium azide (SA) and ethidium bromide (EB) in TA 100 and TA 98 mutant strains, respectively, decreased with increasing amounts of FDE, while increasing levels of BE suppressed the number of revertants in TA 98 in the presence of EB, but exerted little influence on the mutagenicity of SA in TA 100. No difference was observed in the antimutagenic action between the irradiated and unirradiated vegetable extracts. Both the FDE and BE preparations suppressed the action of a frameshift mutagen, but with a base-pair mutagen only the FDE or uncooked vegetable extracts produced suppression. (author)

  10. Preliminary data from lithium hydride ablation tests conducted by NASA, Ames Research Center

    International Nuclear Information System (INIS)

    Elliott, R.D.

    1970-01-01

    A series of ablation tests of lithium hydride has been made by NASA-Ames in one of their high-enthalpy arc-heated wind tunnels. Two-inch diameter cylindrical samples of the hydride, supplied by A. I., were subjected to heating on their ends for time periods up to 10 seconds. After each test, the amount of material removed from each sample was measured. The rates of loss of material were correlated with the heat input rates in terms of a heat of ablation, which ranged from 2100 to 3500 Btu/lb. The higher values were obtained when the hydride contained a matrix such as steel honeycomb of steel wool. (U.S.)

  11. The Use of the Ames Test as a Tool for Addressing Problem-Based Learning in the Microbiology Lab

    Directory of Open Access Journals (Sweden)

    Eliana Rodríguez

    2012-08-01

    Full Text Available Our environment is full of potential carcinogens such as UV light, industrial pollutants, pesticides, and food additives, among others. It is estimated that 90% of all carcinogens are also mutagens. The Ames test is one of the most common tests for mutagens. In this problem-based learning activity, undergraduate biology students used the Ames test to screen a substance they provided, to see if it could be considered a mutagen. The idea of surveying substances used in everyday life appealed to our students, and helped engage them in this activity.

  12. Mutagenic activity of a fluorinated analog of the beta-adrenoceptor ligand carazolol in the Ames test

    Energy Technology Data Exchange (ETDEWEB)

    Doze, P. E-mail: P.Doze@pet.azg.nl; Elsinga, P.H.; Vries, E.F.J. de; Waarde, A. van; Vaalburg, W

    2000-04-01

    S-1'[{sup 18}F]-Fluorocarazolol (FCAR) is a fluorinated analog of the nonmutagenic beta-blocker carazolol (CAR). In former studies FCAR proved to be suitable for quantification of beta-adrenoceptors in vivo with positron emission tomography (PET). We report here that FCAR displays no acute toxicity in either rats or mice. However, FCAR induces a strong dose-related increase in the number of revertants in the Ames test. We conclude that FCAR yields mutagenic activity as measured by the Ames test.

  13. Genotoxic, Cytotoxic, Antigenotoxic, and Anticytotoxic Effects of Sulfonamide Chalcone Using the Ames Test and the Mouse Bone Marrow Micronucleus Test.

    Directory of Open Access Journals (Sweden)

    Carolina Ribeiro E Silva

    Full Text Available Chalcones present several biological activities and sulfonamide chalcone derivatives have shown important biological applications, including antitumor activity. In this study, genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of the sulfonamide chalcone N-{4-[3-(4-nitrophenylprop-2-enoyl]phenyl} benzenesulfonamide (CPN were assessed using the Salmonella typhimurium reverse mutation test (Ames test and the mouse bone marrow micronucleus test. The results showed that CPN caused a small increase in the number of histidine revertant colonies in S. typhimurium strains TA98 and TA100, but not statistically significant (p > 0.05. The antimutagenicity test showed that CPN significantly decreased the number of His+ revertants in strain TA98 at all doses tested (p 0.05. Additionally, CPN co-administered with MMC significantly increased PCE/NCE ratio at all doses tested, demonstrating its anticytotoxic effect. In summary, CPN presented genotoxic, cytotoxic, antigenotoxic, and anticytotoxic properties.

  14. Analysis of plant extracts antimutagenicity using the Ames test and the cytogenetic analysis of peripheral blood lymphocytes

    Czech Academy of Sciences Publication Activity Database

    Buňková, R.; Marová, I.; Pokorná, Z.; Lojek, Antonín

    2005-01-01

    Roč. 11, č. 2 (2005), s. 107-112 ISSN 1082-0132 Institutional research plan: CEZ:AV0Z50040507 Keywords : plant extracts * antioxidative activity * Ames test Subject RIV: BO - Biophysics Impact factor: 0.724, year: 2005

  15. Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult. G. Don. evaluated by Ames test

    Directory of Open Access Journals (Sweden)

    C. C. Carneiro

    2017-09-01

    Full Text Available Abstract Salacia crassifolia (Mart. Ex. Schult. G. Don. is a bush which belongs to Celastraceae family and occurs specially in Brazilian Cerrado. Its leaves, stem, seeds and fruits are popularly used for several medicinal purposes, such as antitumoral, antirheumatic, anti-inflammatory and antimicrobial. In this study, the mutagenic and antimutagenic activities of S. crassifolia stem bark fractions (hexane, ethyl acetate and hydroalcoholic were evaluated by the Ames mutagenicity assay in Salmonella typhimurium TA98 and TA100 strains. By the obtained results, all S. crassifolia fractions did not significantly increase the number of prototrophic revertants for histidine (His+ in both S. typhimurium strains tested (p > 0.05, suggesting absence of mutagenicity. Regarding antimutagenicity, the fractions ethyl acetate and hydroalcoholic significantly decreased the number of His+ revertants colonies induced by positive control for strain TA98 (p < 0.05, demonstrating protection against mutagenicity induced by 4-nitroquinolile1-oxide, whereas the hexane fraction did not show antimutagenic effect in this strain. In the TA100 strain, all fractions of S. crassifolia protected DNA against the harmful action of sodium azide, and the hexane fraction exhibited the greatest protection in this work. Thus, it’s possible conclude that the fractions of S. crassifolia tested in this study could be used in chemoprevention.

  16. Autonomy @ Ames

    Science.gov (United States)

    Van Dalsem, William; Krishnakumar, Kalmanje Srinivas

    2016-01-01

    This is a powerpoint presentation that highlights autonomy across the 15 NASA technology roadmaps, including specific examples of projects (past and present) at NASA Ames Research Center. The NASA technology roadmaps are located here: http:www.nasa.govofficesocthomeroadmapsindex.html

  17. A critical review of the life sciences project management at Ames Research Center for the Spacelab Mission development test 3

    Science.gov (United States)

    Helmreich, R. L.; Wilhelm, J. M.; Tanner, T. A.; Sieber, J. E.; Burgenbauch, S. F.

    1979-01-01

    A management study was initiated by ARC (Ames Research Center) to specify Spacelab Mission Development Test 3 activities and problems. This report documents the problems encountered and provides conclusions and recommendations to project management for current and future ARC life sciences projects. An executive summary of the conclusions and recommendations is provided. The report also addresses broader issues relevant to the conduct of future scientific missions under the constraints imposed by the space environment.

  18. Microplate Ames MPF™ test use in assessment of mutagenic properties of dust pollution

    Directory of Open Access Journals (Sweden)

    Agnieszka Kozłowska

    2012-09-01

    Full Text Available Background: Highly industrialized Upper Silesia Region is particularly polluted by both anthropogenic and natural airborne particulate matters, which may lead to negative health effects in human. Materials and methods: The aim of the study was to assess the mutagenic properties of dust extracts which were collected in six cities in the Silesian Voivodeship. Dust samples were collected on glass fiber filters by the aspirator with air flow ca. 1 m3/min. Extraction of pollution was carried out using dichlorometane. The extracted samples were dissolved in dimethylsulfoxide (DMSO. The mutagenic properties were assessed using microplate Ames assay MPFTM with the use of bacteria Salmonella typhimurium strain TA98 and TA100. Results: In microplate Ames assay MPFTM there was observed a linear dose-response relationship in both metabolic variants of TA98 strain. Similar relationship was observed for TA100 strain with metabolic activation (S9. Mutagenic activity (AM of 100% extracts for TA98 strain in both metabolic variants (S9 exceeded 2, what indicate highly mutagenic effects of dust extracts. There was no mutagenic activity observed in the assay with TA100 (S9, AM 1. In the variant with exogenous metabolic activation (S9 in TA100 strain AM values ranged from AM1,160,15 to AM9,671,02. Mutagenic activity varied between different cities. Conclusions: The study demonstrated that microplate Ames assay MPFTM is fast and complex method of assessing the mutagenic properties of dust pollution, which exert toxic effect on organisms. The use of microplate Ames assay MPFTM together with chemical analyses of air dust pollution may evaluate the level of exposure in the environment and enable to perform health risk assessment in populations exposed to mutagenic, toxic and cytotoxic substances.

  19. Construction of a 2- by 2-foot transonic adaptive-wall test section at the NASA Ames Research Center

    Science.gov (United States)

    Morgan, Daniel G.; Lee, George

    1986-01-01

    The development of a new production-size, two-dimensional, adaptive-wall test section with ventilated walls at the NASA Ames Research Center is described. The new facility incorporates rapid closed-loop operation, computer/sensor integration, and on-line interference assessment and wall corrections. Air flow through the test section is controlled by a series of plenum compartments and three-way slide vales. A fast-scan laser velocimeter was built to measure velocity boundary conditions for the interference assessment scheme. A 15.2-cm- (6.0-in.-) chord NACA 0012 airfoil model will be used in the first experiments during calibration of the facility.

  20. Urine recovery experiments with quercetin and other mutagens using the Ames test

    Energy Technology Data Exchange (ETDEWEB)

    Busch, D.B.; Hatcher, J.F.; Bryan, G.T.

    1986-01-01

    Recovery from urine of the mutagenic activity of 2-anthramine, cyclophosphamide, 7,12-dimethylbenz(a)anthracene, 6-chloro-9-((3-(2-chloroethylamino)-propyl)amino)-2-methoxyacridine dihydrochloride (ICR-191), mitomycin-C, nitrofurantoin, and quercetin was studied with several of the Ames tester strains using acetone-extracted XAD-2 columns with yields ranging from 27% to 79%. Dose responses of the pure chemicals were also studied, and results showed TA 97 to be far more susceptible to quercetin mutagenesis than TA 1537. Reducing pour plate agar volume enhanced mutagenesis.

  1. Experiences with a high-blockage model tested in the NASA Ames 12-foot pressure wind tunnel

    Science.gov (United States)

    Coder, D. W.

    1984-01-01

    Representation of the flow around full-scale ships was sought in the subsonic wind tunnels in order to a Hain Reynolds numbers as high as possible. As part of the quest to attain the largest possible Reynolds number, large models with high blockage are used which result in significant wall interference effects. Some experiences with such a high blockage model tested in the NASA Ames 12-foot pressure wind tunnel are summarized. The main results of the experiment relating to wind tunnel wall interference effects are also presented.

  2. In vitro mutagenicity assay (Ames test and phytochemical characterization of seeds oil of Helianthus annuus Linné (sunflower

    Directory of Open Access Journals (Sweden)

    Nelma de Mello Silva Oliveira

    Full Text Available The objective of this research was to investigate the genotoxic potential of the oil of H. annuus L. (sunflower seeds via the Ames test as well as its oxidative properties and lipid composition. The pre-incubation method, system metabolic activation (S9 fraction and five S. typhimurium strains (TA97, TA98, TA100, TA1535 and TA102 were employed for the Ames test. The oxidative stability and fatty acid composition were analyzed by standard methods and gas chromatography. A revertant analysis showed no significant differences between the treatment doses (10–200 μl/plate and the negative controls, regardless of S9+ and S9−, and included all of the S. typhimurium strains. Chromatographic analysis showed high levels of polyunsaturated fatty acids, followed by monounsaturated, saturated and total trans-isomers. Among the polyunsaturated, monounsaturated and saturated fatty acids, linoleic, oleic and palmitic acids predominated. The results suggest that the sunflower oil is not genotoxic as indicated by frameshift mutations and base pair substitutions regardless of the treatment dose, but shows dose-dependent toxicity. The oxidative properties of the sunflower oil were consistent with the requirements of national and international standards. However, its composition could also indicate phytotherapeutic properties. Keywords: Helianthus annuus L., Sunflower oil, Genetic toxicity, Gas chromatography

  3. Mutagenicity Evaluation of Ammonium Picrate in the Ames Salmonella/Microsome Plate Test. Segment Report,

    Science.gov (United States)

    1979-02-01

    used by the I study director, and any % ppendices . All test and control results presented in this report are suppreted by raw data .which are permanently...dosage selection results are presented in Table 1. The acute and subchronic test results have been collected from raw data sheets and tabulated in...breakage in bone marrow cells of mice following oral exposure (per os). Both acute and subchronic dosing schedules were employed in this assay. Results

  4. Extreme testing of undiluted e-cigarette aerosol in vitro using an Ames air-agar-interface technique.

    Science.gov (United States)

    Thorne, D; Hollings, M; Seymour, A; Adamson, J; Dalrymple, A; Ballantyne, M; Gaca, M

    2018-04-01

    There is a growing consensus that e-cigarettes hold the potential for reducing the harm associated with cigarette smoking. Recently published studies have reported in vitro testing of e-cigarettes, demonstrating reduced toxicological and biological effects. Few studies however have reported the use of e-cigarettes under extreme testing conditions. To assess the full mutagenic potential of a commercially available electronic-cigarette (Vype ePen), this study investigated the delivery of aerosol under extreme conditions, using a scaled-down 35 mm plate Ames bacterial reverse mutagenicity assay. S. typhimurium strains TA98, TA100, TA97, TA104 and E. coli WP2 uvrA pKM101 with or without metabolic activation (S9), were employed. Using a modified Vitrocell VC 10 exposure system 0, 180, 360, 540, 720 or 900 puffs of undiluted e-cigarette aerosol was generated and delivered to bacterial cultures aligned to reported human consumption data. The results demonstrate that no mutagenic activity was observed in any strain under any test condition even when exposed to 900 puffs of undiluted e-cigarette aerosols +/- S9. Positive control responses were observed in all strains +/- S9. Nicotine assessments demonstrated an increased and consistent aerosol delivery, with calculated maximum doses of ∼1 mg/mL delivery of nicotine. These data demonstrate the validity of this unique testing approach and adds further information to the growing weight of evidence that e-cigarettes offer substantially reduced exposure when compared to conventional cigarette smoke. For future in vitro assessments of next generation tobacco and nicotine products, the generation, delivery and testing of undiluted aerosols can now be considered. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  5. Situational judgement tests in medical education and training: Research, theory and practice: AMEE Guide No. 100.

    Science.gov (United States)

    Patterson, Fiona; Zibarras, Lara; Ashworth, Vicki

    2016-01-01

    Why use SJTs? Traditionally, selection into medical education professions has focused primarily upon academic ability alone. This approach has been questioned more recently, as although academic attainment predicts performance early in training, research shows it has less predictive power for demonstrating competence in postgraduate clinical practice. Such evidence, coupled with an increasing focus on individuals working in healthcare roles displaying the core values of compassionate care, benevolence and respect, illustrates that individuals should be selected on attributes other than academic ability alone. Moreover, there are mounting calls to widen access to medicine, to ensure that selection methods do not unfairly disadvantage individuals from specific groups (e.g. regarding ethnicity or socio-economic status), so that the future workforce adequately represents society as a whole. These drivers necessitate a method of assessment that allows individuals to be selected on important non-academic attributes that are desirable in healthcare professionals, in a fair, reliable and valid way. What are SJTs? Situational judgement tests (SJTs) are tests used to assess individuals' reactions to a number of hypothetical role-relevant scenarios, which reflect situations candidates are likely to encounter in the target role. These scenarios are based on a detailed analysis of the role and should be developed in collaboration with subject matter experts, in order to accurately assess the key attributes that are associated with competent performance. From a theoretical perspective, SJTs are believed to measure prosocial Implicit Trait Policies (ITPs), which are shaped by socialisation processes that teach the utility of expressing certain traits in different settings such as agreeable expressions (e.g. helping others in need), or disagreeable actions (e.g. advancing ones own interest at others, expense). Are SJTs reliable, valid and fair? Several studies, including good

  6. Modification of γ-induced mutagenesis in Ames test-strains

    International Nuclear Information System (INIS)

    Basha, S.G.; Krasavin, E.A.; Kozubek, S.; Amirtaev, K.G.

    1990-01-01

    Glycerine and cysteamine protective effect on mutagenesis was studied in 3 strains of Salmonella typhimurium under γ-radiation. Glycerine modifying effect was shown to be not similar for various test-strains and depended on DNA injury nature. DNA complex injuries were shown to play significant role in mutagenesis of TA100 and TA102 strains. Absence of cysteamine modifying effect on γ-induced mutagenesis testified to cysteamine effect on enzyme balance. 20 refs.; 2 figs.; 1 tab

  7. Post-examination interpretation of objective test data: monitoring and improving the quality of high-stakes examinations--a commentary on two AMEE Guides.

    Science.gov (United States)

    Tavakol, Mohsen; Dennick, Reg

    2012-01-01

    As great emphasis is rightly placed upon the importance of assessment to judge the quality of our future healthcare professionals, it is appropriate not only to choose the most appropriate assessment method, but to continually monitor the quality of the tests themselves, in a hope that we may continually improve the process. This article stresses the importance of quality control mechanisms in the exam cycle and briefly outlines some of the key psychometric concepts including reliability measures, factor analysis, generalisability theory and item response theory. The importance of such analyses for the standard setting procedures is emphasised. This article also accompanies two new AMEE Guides in Medical Education (Tavakol M, Dennick R. Post-examination Analysis of Objective Tests: AMEE Guide No. 54 and Tavakol M, Dennick R. 2012. Post examination analysis of objective test data: Monitoring and improving the quality of high stakes examinations: AMEE Guide No. 66) which provide the reader with practical examples of analysis and interpretation, in order to help develop valid and reliable tests.

  8. Comparative genotoxicity testing of Rhine river sediment extracts using the comet assay with permanent fish cell lines (RTG-2 and RTL-W1) and the Ames test

    Energy Technology Data Exchange (ETDEWEB)

    Kosmehl, T.; Braunbeck, T.; Hollert, H. [Dept. of Zoology, Aquatic Ecology and Toxicology Section, Univ. of Heidelberg (Germany); Krebs, F.; Manz, W. [German Federal Inst. of Hydrology, Koblenz (Germany); Erdinger, L. [Dept. for Hygiene and Medical Microbiology, Inst. for Hygiene, Univ. of Heidelberg (Germany)

    2004-07-01

    Whilst at least in Germany assessment strategies on the basis of chemical analysis and acute toxicity data dominated the last decades, the development of more specific biological endpoints and biomarkers in ecotoxicology is required in order to arrive at a good ecological potential and good chemical status of surface waters in the European river basins until the year 2015, as required by the European Water Framework Directive. Since sediments have for long been known to function both as a sink and as a source of pollutants in aquatic systems, and since part of the particle-associated substances have frequently been demonstrated to cause mutagenic and carcinogenic effects in aquatic organisms, particularly in fish, there is, among other requirements, an urgent need to develop, standardize and implement integrated vertebrate-based test systems addressing genotoxicity into recent sediment investigation strategies. Thus, the present study was designed to compare the suitability of two commonly used test systems, the comet assay and the Ames test, for the evaluation of the ecotoxicological burden of surface and core sediment samples from the river Rhine. Methods (or main features). In order to determine the importance of inherent enzymatic activities, two permanent fish cell lines with different biotransformation capacities, RTL-W1 and RTG-2, were compared with respect to their capability of detecting genotoxic effects in 18 surface and core sediment samples from 9 locations along the river Rhine in the comet assay with and without exogenous bioactivation. For further comparison, as a prokaryotic mutagenicity assay, the Salmonella plate incorporation assay (Ames test) with the test strains TA98 and TA100 with and without exogenous metabolic activation was used. Results and discussion. Whereas all sediment extracts induced genotoxic effects in the comet assay with RTL-W1 cells, only 12 out of 18 sediment extracts revealed significant genotoxicity in the tests with the

  9. Acoustic Modifications of the Ames 40x80 Foot Wind Tunnel and Test Techniques for High-Speed Research Model Testing

    Science.gov (United States)

    Soderman, Paul T.; Olson, Larry (Technical Monitor)

    1995-01-01

    The NFAC 40- by 80- Foot Wind Tunnel at Ames is being refurbished with a new, deep acoustic lining in the test section which will make the facility nearly anechoic over a large frequency range. The modification history, key elements, and schedule will be discussed. Design features and expected performance gains will be described. Background noise reductions will be summarized. Improvements in aeroacoustic research techniques have been developed and used recently at NFAC on several wind tunnel tests of High Speed Research models. Research on quiet inflow microphones and struts will be described. The Acoustic Survey Apparatus in the 40x80 will be illustrated. A special intensity probe was tested for source localization. Multi-channel, high speed digital data acquisition is now used for acoustics. And most important, phased microphone arrays have been developed and tested which have proven to be very powerful for source identification and increased signal-to-noise ratio. Use of these tools for the HEAT model will be illustrated. In addition, an acoustically absorbent symmetry plane was built to satisfy the HEAT semispan aerodynamic and acoustic requirements. Acoustic performance of that symmetry plane will be shown.

  10. Critical review of Ames Life Science participation in Spacelab Mission Development Test 3: The SMD 3 management study

    Science.gov (United States)

    Helmreich, R.; Wilhelm, J.; Tanner, T. A.; Sieber, J. E.; Burgenbauch, S.

    1978-01-01

    A management study was conducted to specify activities and problems encountered during the development of procedures for documentation and crew training on experiments, as well as during the design, integration, and delivery of a life sciences experiment payload to Johnson Space Center for a 7 day simulation of a Spacelab mission. Conclusions and recommendations to project management for current and future Ames' life sciences projects are included. Broader issues relevant to the conduct of future scientific missions under the constraints imposed by the environment of space are also addressed.

  11. In vitro genotoxicity of neutral red after photo-activation and metabolic activation in the Ames test, the micronucleus test and the comet assay.

    Science.gov (United States)

    Guérard, Melanie; Zeller, Andreas; Singer, Thomas; Gocke, Elmar

    2012-07-04

    Neutral red (Nr) is relatively non-toxic and is widely used as indicator dye in many biological test systems. It absorbs visible light and is known to act as a photosensitizer, involving the generation of reactive oxygen species (type-I reaction) and singlet oxygen (type-II reaction). The mutagenicity of Nr was determined in the Ames test (with Salmonella typhimurium strains TA1535, TA97, TA98, TA98NR, TA100, and TA102) with and without metabolic activation, and with and without photo-activation on agar plates. Similarly to the situation following metabolic activation, photo-mutagenicity of Nr was seen with all Salmonella strains tested, albeit with different effects between these strains. To our knowledge, Nr is the only photo-mutagen showing such a broad action. Since the effects are also observed in strains not known to be responsive to ROS, this indicates that ROS production is not the sole mode of action that leads to photo-genotoxicity. The reactive species produced by irradiation are short-lived as pre-irradiation of an Nr solution did not produce mutagenic effects when added to the bacteria. In addition, mutagenicity in TA98 following irradiation was stronger than in the nitroreductase-deficient strain TA98NR, indicating that nitro derivatives that are transformed by bacterial nitroreductase to hydroxylamines appear to play a role in the photo-mutagenicity of Nr. Photo-genotoxicity of Nr was further investigated in the comet assay and micronucleus test in L5178Y cells. Concentration-dependent increases in primary DNA damage and in the frequency of micronuclei were observed after irradiation. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Mutagens from the cooking of food. II. Survey by Ames/Salmonella test of mutagen formation in the major protein-rich foods of the American diet

    Energy Technology Data Exchange (ETDEWEB)

    Bjeldanes, L.F. (Univ. of California, Berkeley); Morris, M.M.; Felton, J.S.; Healy, S.; Stuermer, D.; Berry, P.; Timourian, H.; Hatch, F.T.

    1982-01-01

    The formation of mutagens in the major cooked protein-rich foods in the US diet was studied in the Ames Salmonella typhimurium test. The nine protein-rich foods most commonly eaten in the USA--ground beef, beef steak, eggs, pork chops, fried chicken, pot-roasted beef, ham, roast beef and bacon--were examined for their mutagenicity towards S. typhimurium TA1538 after normal 'household' cooking (deep frying, griddle/pan frying, baking/roasting, broiling, stewing, braising or boiling at 100-475/sup 0/C). Well-done fried ground beef, beef steak, ham, pork chops and bacon showed significant mutagen formation. For chicken and beef steak high-temperature broiling produced the most mutagenicity, followed by baking/roasting and frying. Stewing, braising and deep frying produced little mutagen. Eggs andd egg products produced mutagens only after cooking at high temperatures (the yolk to a greater extent than the white). Commercially cooked hamburgers showed a wide range of mutagenic activity. We conclude that mutagen formation following cooking of protein-containing foods is a complex function of food type, cooking time and cooking temperature. It seems clear that all the major protein-rich foods if cooked to a well-done state on the griddle (eggs only at temperature above 225/sup 0/C) or by broiling will contain mutagens detectable by the Ames/Salmonella assay. This survey is a step towards determining whether any human health hazard results from cooking protein-rich foods. Further testing in both short- and long-term genotoxicity bioassays and carcinogenesis assays are needed before any human risk extrapolations can be made.

  13. Mutagens from the cooking of food. II. Survey by Ames/Salmonella test of mutagen formation in the major protein-rich foods of the American diet.

    Science.gov (United States)

    Bjeldanes, L F; Morris, M M; Felton, J S; Healy, S; Stuermer, D; Berry, P; Timourian, H; Hatch, F T

    1982-08-01

    The formation of mutagens in the major cooked protein-rich foods in the US diet was studied in the Ames Salmonella typhimurium test. The nine protein-rich foods most commonly eaten in the USA--ground beef, beef steak, eggs, pork chops, fried chicken, pot-roasted beef, ham, roast beef and bacon--were examined for their mutagenicity towards S. typhimurium TA1538 after normal 'household' cooking (deep frying, griddle/pan frying, baking/roasting, broiling, stewing, braising or boiling of 100-475 degrees C). Well-done fried ground beef, beef steak, ham pork chops and bacon showed significant mutagen formation. For chicken and beef steak high-temperature broiling produced the most mutagenicity, followed by baking/roasting and frying. Stewing, braising and deep frying produced little mutagen. Eggs and egg products produced mutagens only after cooking at high temperatures (the yolk to a greater extent than the white). Commercially cooked hamburgers showed a wide range of mutagenic activity. We conclude that mutagen formation following cooking of protein-containing foods is a complex function of food type, cooking time and cooking temperature. It seems clear that all the major protein-rich foods if cooked to a well-done state on the griddle (eggs only at temperatures above 225 degrees C) or by broiling will contain mutagens detectable by the Ames/Salmonella assay. This survey is a step towards determining whether any human health hazard results from cooking protein-rich foods. Further testing in both short- and long-term genotoxicity bioassays and carcinogenesis assays are needed before any human risk extrapolations can be made.

  14. Low-speed tests of a high-aspect-ratio, supercritical-wing transport model equipped with a high-lift flap system in the Langley 4- by 7-meter and Ames 12-foot pressure tunnels

    Science.gov (United States)

    Morgan, H. L., Jr.; Kjelgaard, S. O.

    1983-01-01

    The Ames 12-Foot Pressure Tunnel was used to determine the effects of Reynolds number on the static longitudinal aerodynamic characteristics of an advanced, high-aspect-ratio, supercritical wing transport model equipped with a full span, leading edge slat and part span, double slotted, trailing edge flaps. The model had a wing span of 7.5 ft and was tested through a free stream Reynolds number range from 1.3 to 6.0 x 10 to 6th power per foot at a Mach number of 0.20. Prior to the Ames tests, an investigation was also conducted in the Langley 4 by 7 Meter Tunnel at a Reynolds number of 1.3 x 10 to 6th power per foot with the model mounted on an Ames strut support system and on the Langley sting support system to determine strut interference corrections. The data obtained from the Langley tests were also used to compare the aerodynamic charactertistics of the rather stiff, 7.5-ft-span steel wing model tested during this investigation and the larger, and rather flexible, 12-ft-span aluminum-wing model tested during a previous investigation. During the tests in both the Langley and Ames tunnels, the model was tested with six basic wing configurations: (1) cruise; (2) climb (slats only extended); (3) 15 deg take-off flaps; (4) 30 deg take-off flaps; (5) 45 deg landing flaps; and (6) 60 deg landing flaps.

  15. Force Tests of the Boeing XB-47 Full-Scale Empennage in the Ames 40- by 80-Foot Wind Tunnel

    Science.gov (United States)

    Hunton, Lynn W.

    1947-01-01

    A wind-tunnel investigation of the Boeing XB-47 full-scale empennage was conducted to provide, prior to flight tests, data required on the effectiveness of the elevator and rudder. The XB-47 airplane is a jet-propelled medium bomber having wing and tail surfaces swept back 35 degrees. The investigation included tests of the effectiveness of the elevator with normal straight sides, with a buldged trailing edge, and with a modified hinge-line gap and tests of the effectiveness of the rudder with a normal straight-sided tab and with a bulged tab.

  16. Genotoxicity investigation of araticum(Annona crassiflora Mart., 1841, Annonaceae using SOS-Inductest and Ames test

    Directory of Open Access Journals (Sweden)

    JB. Vilar

    Full Text Available Although the use of medicinal plants or natural products has increased in recent decades all over the world, little information is available on their potential risk to health. Annona crassiflora Mart., a plant commonly known as araticum in Brazil, has been widely used in folk medicine for a long time since its seeds and leaves are often utilised in the treatment of cancer, snake bites, and venereal diseases, its fruits are consumed as tonic and astringent, and its bark powder has anti-fungal and anti-rheumatic properties. To evaluate the genotoxic and mutagenic properties induced by the ethanolic extract of araticum leaves, we performed the prophage λ induction (Inductest and bacterial mutagenicity assays. We used Escherichia coli WP2s(λ and RJF013 strains in the lysogenic induction test, whereas the mutagenic studies were carried out using Salmonella typhimurium histidine auxotroph strains TA97a, TA98, TA100, and TA102. Each experiment was performed three times in duplicate and included positive and negative controls. No statistically significant (p > 0.05 positive results were obtained for any of the strains tested, which suggests that the ethanolic extract of araticum leaves did not exhibit direct mechanisms of genotoxicity or mutagenicity that could be detected by the tests used in the present work.

  17. Mutagens from the cooking of food. III. Survey by Ames/Salmonella test of mutagen formation in secondary sources of cooked dietary protein

    Energy Technology Data Exchange (ETDEWEB)

    Bjeldanes, L F [Univ. of California, Berkeley; Morris, M M; Felton, J S; Healy, S; Stuermer, D; Berry, P; Timourian, H; Hatch, F T

    1982-01-01

    A survey of mutagen formation during the cooking of a variety of protein-rich foods that are minor sources of protein intake in the American diet is reported (see Bjeldanes, Morris, Felton et al. (1982) for survey of major protein foods). Milk, cheese, tofu and organ meats showed negligible mutagen formation except following high-temperature cooking for long periods of time. Even under the most extreme conditions, tofu, cheese and milk exhibited fewer than 500 Ames/Salmonella typhimurium revertants/100 g equivalents (wet weight of uncooked food), and organ meats only double that amount. Beans showed low mutagen formation after boiling followed by frying (with and without oil). Only boiling of beans followed by baking for 1 hr gave appreciable mutagenicity (3650 revertants/100 g equivalents). Seafood samples gave a variety of results: red snapper, salmon, trout, halibut and rock cod all gave more than 1000 revertants/100 g wet weight equivalents when pan-fried or griddle-fried for about 6 min/side. Baked or poached rock cod and deep-fried shrimp showed no significant mutagen formation. Broiled lamb chops showed mutagen formation similar to that in red meats tested in the preceding paper: 16,000 revertants/100 g equivalents. These findings show that as measured by bioassay in S. typhimurium, most of the food that are minor sources of protein in the American diet are also minor sources of cooking-induced mutagens.

  18. Mutagens from the cooking of food. III. Survey by Ames/Salmonella test of mutagen formation in secondary sources of cooked dietary protein.

    Science.gov (United States)

    Bjeldanes, L F; Morris, M M; Felton, J S; Healy, S; Stuermer, D; Berry, P; Timourian, H; Hatch, F T

    1982-08-01

    A survey of mutagen formation during the cooking of a variety of protein-rich foods that are minor sources of protein intake in the American diet is reported (see Bjeldanes, Morris, Felton et al. (1982) for survey of major protein foods). Milk, cheese, tofu and organ meats showed negligible mutagen formation except following high-temperature cooking for long periods of time. Even under the most extreme conditions, tofu, cheese and milk exhibited fewer than 500 Ames/Salmonella typhimurium revertants/100 g equivalents (wet weight of uncooked food), and organ meats only double that amount. Beans showed low mutagen formation after boiling and boiling followed by frying (with and without oil). Only boiling of beans followed by baking for 1 hr gave appreciable mutagenicity (3650 revertants/100g equivalents). Seafood samples gave a variety of results: red snapper, salmon, trout, halibut and rock cod all gave more than 1000 revertants/100 g wet weight equivalents when pan-fried or griddle-fried for about 6 min/side. Baked or poached rock and deep-fried shrimp showed no significant mutagen formation. Broiled lamb chops showed mutagen formation similar to that in red meats tested in the preceding paper: 16,000 revertants/100 g equivalents. These findings show that as measured by bioassay in S. typhimurium, most of the foods that are minor sources of protein in the American diet are also minor sources of cooking-induced mutagens.

  19. Plans for Testing the NREL Unsteady Aerodynamics Experiment 10m Diameter HAWT in the NASA Ames Wind Tunnel: Minutes, Conclusions, and Revised Text Matrix from the 1st Science Panel Meeting

    Energy Technology Data Exchange (ETDEWEB)

    Simms, D.; Schreck, S.; Hand, M.; Fingersh, L.; Cotrell, J.; Pierce, K.; Robinson, M.

    2000-08-28

    Currently, the NREL Unsteady Aerodynamics Experiment (UAE) research turbine is scheduled to enter the NASA Ames 80-ft x 120-ft wind tunnel in early 2000. To prepare for this 3-week test, a Science Panel meeting was convened at the National Wind Technology Center (NWTC) in October 1998. During this meeting, the Science Panel and representatives from the wind energy community provided numerous detailed recommendations regarding test activities and priorities. The Unsteady Aerodynamics team of the NWTC condensed this guidance and drafted a detailed test plan. This test plan represents an attempt to balance diverse recommendations received from the Science Panel meeting, while taking into account multiple constraints imposed by the UAE research turbine, the NASA Ames 80-ft x 120-ft wind tunnel, and other sources. The NREL-NASA Ames wind tunnel tests will primarily be focused on obtaining rotating blade pressure data. NREL has been making these types of measurements since 1987 and has considerable experience in doing so. The purpose of this wind tunnel test is to acquire accurate quantitative aerodynamic and structural measurements, on a wind turbine that is geometrically and dynamically representative of full-scale machines, in an environment free from pronounced inflow anomalies. These data will be exploited to develop and validate enhanced engineering models for designing and analyzing advanced wind energy machines.

  20. Routine environmental audit of Ames Laboratory, Ames, Iowa

    International Nuclear Information System (INIS)

    1994-09-01

    This document contains the findings identified during the routine environmental audit of Ames Laboratory, Ames, Iowa, conducted September 12--23, 1994. The audit included a review of all Ames Laboratory operations and facilities supporting DOE-sponsored activities. The audit's objective is to advise the Secretary of Energy, through the Assistant Secretary for Environment, Safety and Health, as to the adequacy of the environmental protection programs established at Ames Laboratory to ensure the protection of the environment, and compliance with Federal, state, and DOE requirements

  1. Spatial delayed nonmatching-to-sample performances in long-living Ames dwarf mice.

    Science.gov (United States)

    Derenne, Adam; Brown-Borg, Holly M; Martner, Sarah; Wolff, Wendy; Frerking, Morgan

    2014-01-17

    Ames dwarf mice have an extended lifespan by comparison with normal mice. Behavioral testing has revealed that sometimes Ames dwarf mice also evince superior performances relative to normal mice, but in other cases they do not. In this experiment, Ames dwarf and normal mice were compared on a T-maze test and on a delayed nonmatching-to-sample variant of a T-maze test. On the simple T-maze, Ames dwarf and normal mice committed comparable numbers of errors. On the nonmatching-to-sample task, normal mice mastered the discrimination by the end of the experiment while Ames dwarf mice did not. The apparatus, distances traveled and session duration were equivalent between the two tasks. The poorer performances of Ames dwarf mice on the nonmatching-to-sample task suggests that Ames dwarf mice may not be as capable of learning relatively cognitively complex tasks as normal mice. © 2013.

  2. Space Shuttle AFRSI OMS pod environment test using model 81-0 test fixture in the Ames Research Center 9x7-foot supersonic wind tunnel (OS-314A/B/C)

    Science.gov (United States)

    Collette, J. G. R.

    1984-01-01

    A test was conducted in the NASA/Ames Research Center 9x7-foot Supersonic Wind Tunnel to help resolve an anomaly that developed during the STS-6 orbiter flight wherein sections of the Advanced Flexible Reusable Surface Insulation (AFRSI) covering the OMS pods suffered some damage. A one-third scale two-dimensional shell structure model of an OMS pod cross-section was employed to support the test articles. These consisted of 15 AFRSI blanket panels form-fitted over the shell structures for exposure to simulated flight conditions. Of six baseline blankets, two were treated with special surface coatings. Two other panels were configured with AFRSI sections removed from the OV099 orbiter vehicle after the STS-6 flight. Seven additional specimens incorporated alternative designs and repairs. Following a series of surface pressure calibration runs, the specimens were exposed to simulated ascent and entry dynamic pressure profiles. Entry conditions included the use of a vortex generator to evaluate the effect of shed vortices on the AFRSI located in the area of concern.

  3. Ames Optimized TCA Configuration

    Science.gov (United States)

    Cliff, Susan E.; Reuther, James J.; Hicks, Raymond M.

    1999-01-01

    Configuration design at Ames was carried out with the SYN87-SB (single block) Euler code using a 193 x 49 x 65 C-H grid. The Euler solver is coupled to the constrained (NPSOL) and the unconstrained (QNMDIF) optimization packages. Since the single block grid is able to model only wing-body configurations, the nacelle/diverter effects were included in the optimization process by SYN87's option to superimpose the nacelle/diverter interference pressures on the wing. These interference pressures were calculated using the AIRPLANE code. AIRPLANE is an Euler solver that uses a unstructured tetrahedral mesh and is capable of computations about arbitrary complete configurations. In addition, the buoyancy effects of the nacelle/diverters were also included in the design process by imposing the pressure field obtained during the design process onto the triangulated surfaces of the nacelle/diverter mesh generated by AIRPLANE. The interference pressures and nacelle buoyancy effects are added to the final forces after each flow field calculation. Full details of the (recently enhanced) ghost nacelle capability are given in a related talk. The pseudo nacelle corrections were greatly improved during this design cycle. During the Ref H and Cycle 1 design activities, the nacelles were only translated and pitched. In the cycle 2 design effort the nacelles can translate vertically, and pitch to accommodate the changes in the lower surface geometry. The diverter heights (between their leading and trailing edges) were modified during design as the shape of the lower wing changed, with the drag of the diverter changing accordingly. Both adjoint and finite difference gradients were used during optimization. The adjoint-based gradients were found to give good direction in the design space for configurations near the starting point, but as the design approached a minimum, the finite difference gradients were found to be more accurate. Use of finite difference gradients was limited by the

  4. Full-Span Tiltrotor Aeroacoustic Model (TRAM) Overview and 40- by 80-Foot Wind Tunnel Test. [conducted in the 40- by 80-Foot Wind Tunnel at Ames Research Center

    Science.gov (United States)

    McCluer, Megan S.; Johnson, Jeffrey L.; Rutkowski, Michael (Technical Monitor)

    2001-01-01

    Most helicopter data trends cannot be extrapolated to tiltrotors because blade geometry and aerodynamic behavior, as well as rotor and fuselage interactions, are significantly different for tiltrotors. A tiltrotor model has been developed to investigate the aeromechanics of tiltrotors, to develop a comprehensive database for validating tiltrotor analyses, and to provide a research platform for supporting future tiltrotor designs. The Full-Span Tiltrotor Aeroacoustic Model (FS TRAM) is a dual-rotor, powered aircraft model with extensive instrumentation for measurement of structural and aerodynamic loads. This paper will present the Full-Span TRAM test capabilities and the first set of data obtained during a 40- by 80-Foot Wind Tunnel test conducted in late 2000 at NASA Ames Research Center. The Full-Span TRAM is a quarter-scale representation of the V-22 Osprey aircraft, and a heavily instrumented NASA and U.S. Army wind tunnel test stand. Rotor structural loads are monitored and recorded for safety-of-flight and for information on blade loads and dynamics. Left and right rotor balance and fuselage balance loads are monitored for safety-of-flight and for measurement of vehicle and rotor aerodynamic performance. Static pressure taps on the left wing are used to determine rotor/wing interactional effects and rotor blade dynamic pressures measure blade airloads. All of these measurement capabilities make the FS TRAM test stand a unique and valuable asset for validation of computational codes and to aid in future tiltrotor designs. The Full-Span TRAM was tested in the NASA Ames Research Center 40- by 80-Foot Wind Tunnel from October through December 2000. Rotor and vehicle performance measurements were acquired in addition to wing pressures, rotor acoustics, and Laser Light Sheet (LLS) flow visualization data. Hover, forward flight, and airframe (rotors off) aerodynamic runs were performed. Helicopter-mode data were acquired during angle of attack and thrust sweeps for

  5. Pressure distribution data from tests of 2.29 M (7.5 feet) span EET high-lift transport aircraft model in the Ames 12-foot pressure tunnel

    Science.gov (United States)

    Kjelgaard, S. O.; Morgan, H. L., Jr.

    1983-01-01

    A high-lift transport aircraft model equipped with full-span leading-edge slat and part-span double-slotted trailing-edge flap was tested in the Ames 12-ft pressure tunnel to determine the low-speed performance characteristics of a representative high-aspect-ratio supercritical wing. These tests were performed in support of the Energy Efficient Transport (EET) program which is one element of the Aircraft Energy Efficiency (ACEE) project. Static longitudinal forces and moments and chordwise pressure distributions at three spanwise stations were measured for cruise, climb, two take-off flap, and two landing flap wing configurations. The tabulated and plotted pressure distribution data is presented without analysis or discussion.

  6. Ames Air Revitalization

    Science.gov (United States)

    Huang, Roger Z.

    2015-01-01

    This is an informal presentation presented to the University of Colorado, Boulder Bioastronautics group seminar. It highlights the key focal areas of the Air Revitalization Group research over the past year, including progress on the CO2 Removal and Compression System, testing of CDRA drying bed configurations, and adsorption research.

  7. Radiological survey support activities for the decommissioning of the Ames Laboratory Research Reactor Facility, Ames, Iowa

    Energy Technology Data Exchange (ETDEWEB)

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Justus, A.L.; Flynn, K.F.

    1984-09-01

    At the request of the Engineering Support Division of the US Department of Energy-Chicago Operations Office and in accordance with the programmatic overview/certification responsibilities of the Department of Energy Environmental and Safety Engineering Division, the Argonne National Laboratory Radiological Survey Group conducted a series of radiological measurements and tests at the Ames Laboratory Research Reactor located in Ames, Iowa. These measurements and tests were conducted during 1980 and 1981 while the reactor building was being decontaminated and decommissioned for the purpose of returning the building to general use. The results of these evaluations are included in this report. Although the surface contamination within the reactor building could presumably be reduced to negligible levels, the potential for airborne contamination from tritiated water vapor remains. This vapor emmanates from contamination within the concrete of the building and should be monitored until such time as it is reduced to background levels. 2 references, 8 figures, 6 tables.

  8. NASA Ames Environmental Sustainability Report 2011

    Science.gov (United States)

    Clarke, Ann H.

    2011-01-01

    The 2011 Ames Environmental Sustainability Report is the second in a series of reports describing the steps NASA Ames Research Center has taken toward assuring environmental sustainability in NASA Ames programs, projects, and activities. The Report highlights Center contributions toward meeting the Agency-wide goals under the 2011 NASA Strategic Sustainability Performance Program.

  9. Management process invaded Ames as the Center shifted from NACA to NASA oversight. Ames constructed

    Science.gov (United States)

    1968-01-01

    Management process invaded Ames as the Center shifted from NACA to NASA oversight. Ames constructed a review room in its headquarters building where, in the graphical style that prevailed in the 1960's, Ames leadership could review progress against schedule, budget and performance measures. Shown, in October 1965 is Merrill Mead chief of Ames' program and resources office. (for H Julian Allen Retirement album)

  10. NASA-Ames vertical gun

    Science.gov (United States)

    Schultz, P. H.

    1984-01-01

    A national facility, the NASA-Ames vertical gun range (AVGR) has an excellent reputation for revealing fundamental aspects of impact cratering that provide important constraints for planetary processes. The current logistics in accessing the AVGR, some of the past and ongoing experimental programs and their relevance, and the future role of this facility in planetary studies are reviewed. Publications resulting from experiments with the gun (1979 to 1984) are listed as well as the researchers and subjects studied.

  11. UVA activation of N-dialkylnitrosamines releasing nitric oxide, producing strand breaks as well as oxidative damages in DNA, and inducing mutations in the Ames test

    International Nuclear Information System (INIS)

    Arimoto-Kobayashi, Sakae; Sano, Kayoko; Machida, Masaki; Kaji, Keiko; Yakushi, Keiko

    2010-01-01

    We investigated the photo-mutagenicity and photo-genotoxicity of N-dialkylnitrosamines and its mechanisms of UVA activation. With simultaneous irradiation of UVA, photo-mutagenicity of seven N-dialkylnitrosamines was observed in Ames bacteria (Salmonella typhimurium TA1535) in the absence of metabolic activation. Mutagenicity of pre-irradiated N-dialkylnitrosamines was also observed with S. typhimurium hisG46, TA100, TA102 and YG7108 in the absence of metabolic activation. UVA-mediated mutation with N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) decreased by adding either the NO or OH radical scavenger. When superhelical DNA was irradiated with N-dialkylnitrosamines, nicked circular DNA appeared. Ten N-dialkylnitrosamines examined produced strand breaks in the treated DNA in the presence of UVA. The level of single-strand breaks in φX174 DNA mediated by N-nitrosomorpholine (NMOR) and UVA decreased by adding either a radical scavenger or superoxide dismutase. When calf thymus DNA was treated with N-dialkylnitrosamines (NDMA, NDEA, NMOR, N-nitrosopyrrolidine (NPYR) and N-nitrosopiperidine (NPIP)) and UVA, the ratio of 8-oxodG/dG in the DNA increased. Action spectra were obtained to determine if nitrosamine acts as a sensitizer of UVA. Both mutation frequency and NO formation were highest at the absorption maximum of nitrosamines, approximately 340 nm. The plots of NO formation and mutation frequency align with the absorption curve of NPYR, NMOR and NDMA. A significant linear correlation between the optical density of N-dialkynitrosamines at 340 nm and NO formation in each irradiated solution was revealed by ANOVA. We would like to propose the hypothesis that the N-nitroso moiety of N-dialkylnitrosamines absorbs UVA photons, UVA-photolysis of N-dialkylnitrosamines brings release of nitric oxide, and subsequent production of alkyl radical cations and active oxygen species follow as secondary events, which cause DNA strand breaks, oxidative and

  12. UVA activation of N-dialkylnitrosamines releasing nitric oxide, producing strand breaks as well as oxidative damages in DNA, and inducing mutations in the Ames test

    Energy Technology Data Exchange (ETDEWEB)

    Arimoto-Kobayashi, Sakae [Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima, Okayama 700-8530 (Japan); Sano, Kayoko; Machida, Masaki; Kaji, Keiko; Yakushi, Keiko [Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima, Okayama 700-8530 (Japan)

    2010-09-10

    We investigated the photo-mutagenicity and photo-genotoxicity of N-dialkylnitrosamines and its mechanisms of UVA activation. With simultaneous irradiation of UVA, photo-mutagenicity of seven N-dialkylnitrosamines was observed in Ames bacteria (Salmonella typhimurium TA1535) in the absence of metabolic activation. Mutagenicity of pre-irradiated N-dialkylnitrosamines was also observed with S. typhimurium hisG46, TA100, TA102 and YG7108 in the absence of metabolic activation. UVA-mediated mutation with N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) decreased by adding either the NO or OH radical scavenger. When superhelical DNA was irradiated with N-dialkylnitrosamines, nicked circular DNA appeared. Ten N-dialkylnitrosamines examined produced strand breaks in the treated DNA in the presence of UVA. The level of single-strand breaks in {phi}X174 DNA mediated by N-nitrosomorpholine (NMOR) and UVA decreased by adding either a radical scavenger or superoxide dismutase. When calf thymus DNA was treated with N-dialkylnitrosamines (NDMA, NDEA, NMOR, N-nitrosopyrrolidine (NPYR) and N-nitrosopiperidine (NPIP)) and UVA, the ratio of 8-oxodG/dG in the DNA increased. Action spectra were obtained to determine if nitrosamine acts as a sensitizer of UVA. Both mutation frequency and NO formation were highest at the absorption maximum of nitrosamines, approximately 340 nm. The plots of NO formation and mutation frequency align with the absorption curve of NPYR, NMOR and NDMA. A significant linear correlation between the optical density of N-dialkynitrosamines at 340 nm and NO formation in each irradiated solution was revealed by ANOVA. We would like to propose the hypothesis that the N-nitroso moiety of N-dialkylnitrosamines absorbs UVA photons, UVA-photolysis of N-dialkylnitrosamines brings release of nitric oxide, and subsequent production of alkyl radical cations and active oxygen species follow as secondary events, which cause DNA strand breaks, oxidative and

  13. Evaluation of Genotoxicity of CSE1034 by Ames and In vitro ...

    African Journals Online (AJOL)

    NADPH) was obtained from Himedia (Mumbai, India). Ames test. The test was ..... W, Passarge E. Toxicity of antibiotics cultured human skin fibroblast. Humangenetik 1975; 28: 273-267. 15. McCann J, Choi E, Yamasaki E, Ames BN. Detection of.

  14. Ames Life Science Data Archive: Translational Rodent Research at Ames

    Science.gov (United States)

    Wood, Alan E.; French, Alison J.; Ngaotheppitak, Ratana; Leung, Dorothy M.; Vargas, Roxana S.; Maese, Chris; Stewart, Helen

    2014-01-01

    The Life Science Data Archive (LSDA) office at Ames is responsible for collecting, curating, distributing and maintaining information pertaining to animal and plant experiments conducted in low earth orbit aboard various space vehicles from 1965 to present. The LSDA will soon be archiving data and tissues samples collected on the next generation of commercial vehicles; e.g., SpaceX & Cygnus Commercial Cargo Craft. To date over 375 rodent flight experiments with translational application have been archived by the Ames LSDA office. This knowledge base of fundamental research can be used to understand mechanisms that affect higher organisms in microgravity and help define additional research whose results could lead the way to closing gaps identified by the Human Research Program (HRP). This poster will highlight Ames contribution to the existing knowledge base and how the LSDA can be a resource to help answer the questions surrounding human health in long duration space exploration. In addition, it will illustrate how this body of knowledge was utilized to further our understanding of how space flight affects the human system and the ability to develop countermeasures that negate the deleterious effects of space flight. The Ames Life Sciences Data Archive (ALSDA) includes current descriptions of over 700 experiments conducted aboard the Shuttle, International Space Station (ISS), NASA/MIR, Bion/Cosmos, Gemini, Biosatellites, Apollo, Skylab, Russian Foton, and ground bed rest studies. Research areas cover Behavior and Performance, Bone and Calcium Physiology, Cardiovascular Physiology, Cell and Molecular Biology, Chronobiology, Developmental Biology, Endocrinology, Environmental Monitoring, Gastrointestinal Physiology, Hematology, Immunology, Life Support System, Metabolism and Nutrition, Microbiology, Muscle Physiology, Neurophysiology, Pharmacology, Plant Biology, Pulmonary Physiology, Radiation Biology, Renal, Fluid and Electrolyte Physiology, and Toxicology. These

  15. Ames and random amplified polymorphic DNA tests for the validation of the mutagenic and/or genotoxic potential of the drinking water disinfection by-products chloroform and bromoform.

    Science.gov (United States)

    Khallef, Messaouda; Cenkci, Süleyman; Akyil, Dilek; Özkara, Arzu; Konuk, Muhsin; Benouareth, Djamel Eddine

    2018-01-28

    Chloroform and Bromoform are two abundant trihalomethanes found in Algerian drinking water. The investigation of the mutagenic hazard of these disinfection by-products was studied by Ames test as prokaryotic bioassay to show their mutagenic effects. For this, Salmonella typhimurium TA98 and TA100 strains were employed. Both chloroform and bromoform showed a direct mutagenic effect since the number of revertant colonies gradually increase in dose-dependent manner with all concentrations tested with the two bacterial strains and these were both in the absence and presence of S9 metabolic activation. The genotoxic hazard was also studied by random amplified polymorphic DNA test on the root cells of Allium cepa as eukaryotic bioassay. DNA extracted from the roots of the onion were incubated at different concentrations of chloroform and bromoform and then amplified by polymerase chain reaction. This was based on demonstrating a major effect of disappearance of bands compared to roots incubated in the negative control (distilled water). The results showed that these two compounds affected genomic DNA by breaks although by mutations.

  16. Aerodynamic characteristics of a large-scale semispan model with a swept wing and an augmented jet flap with hypermixing nozzles. [Ames 40- by 80-Foot Wind Tunnel and Static Test Facility

    Science.gov (United States)

    Aiken, T. N.; Falarski, M. D.; Koenin, D. G.

    1979-01-01

    The aerodynamic characteristics of the augmentor wing concept with hypermixing primary nozzles were investigated. A large-scale semispan model in the Ames 40- by 80-Foot Wind Tunnel and Static Test Facility was used. The trailing edge, augmentor flap system occupied 65% of the span and consisted of two fixed pivot flaps. The nozzle system consisted of hypermixing, lobe primary nozzles, and BLC slot nozzles at the forward inlet, both sides and ends of the throat, and at the aft flap. The entire wing leading edge was fitted with a 10% chord slat and a blowing slot. Outboard of the flap was a blown aileron. The model was tested statically and at forward speed. Primary parameters and their ranges included angle of attack from -12 to 32 degrees, flap angles of 20, 30, 45, 60 and 70 degrees, and deflection and diffuser area ratios from 1.16 to 2.22. Thrust coefficients ranged from 0 to 2.73, while nozzle pressure ratios varied from 1.0 to 2.34. Reynolds number per foot varied from 0 to 1.4 million. Analysis of the data indicated a maximum static, gross augmentation of 1.53 at a flap angle of 45 degrees. Analysis also indicated that the configuration was an efficient powered lift device and that the net thrust was comparable with augmentor wings of similar static performance. Performance at forward speed was best at a diffuser area ratio of 1.37.

  17. Are All Ames Strains in the OECD Mutagenicity Test Guideline 471 Useful and Necessary? An Analysis of Large Mutagenicity Data Sets for the IWGT

    Science.gov (United States)

    The International Workshop on Genetic Toxicology (IWGT) meets every four years with an objective to reach consensus recommendations on difficult or conflicting approaches to genotoxicity testing based upon practical experience and newly available data and data analysis techniques...

  18. Results of convective heating tests of a longitudinal gap on the Rockwell flat plate model (15-0, insert 7) in the NASA/Ames Research Center

    Science.gov (United States)

    Quan, M.; Lockman, W. K.

    1975-01-01

    Results are presented which were obtained from tests in a hypersonic wind tunnel to determine aerodynamic heating rates in a gap running parallel or slightly askew to the flow direction. The model used was a flat plate instrumented in thin-skin sections with chromelconstantan thermocouples. Heating rate profiles lengthwise along and down into the gap were obtained, and additional data were obtained from a total temperature probe and rake fabricated during the test to investigate an apparent aerodynamic cooling trend in the gap. Model variables were width, depth, length, and orientation of the gap relative to the flow direction. The tests were conducted at Mach 5.1 and Reynolds numbers per foot of 500,000, 1,000,000, and 2,000,000.

  19. Phase 2 and 3 wind tunnel tests of the J-97 powered, external augmentor V/STOL model. [conducted in Ames 40- by 80-foot wind tunnel

    Science.gov (United States)

    Garland, D. B.

    1980-01-01

    Modifications were made to the model to improve longitudinal acceleration capability during transition from hovering to wing borne flight. A rearward deflection of the fuselage augmentor thrust vector is shown to be beneficial in this regard. Other agmentor modifications were tested, notably the removal of both endplates, which improved acceleration performance at the higher transition speeds. The model tests again demonstrated minimal interference of the fuselage augmentor on aerodynamic lift. A flapped canard surface also shows negligible influence on the performance of the wing and of the fuselage augmentor.

  20. Atmosphere of Freedom: Sixty Years at the NASA Ames Research Center

    Science.gov (United States)

    Bugos, Glenn E.; Launius, Roger (Technical Monitor)

    2000-01-01

    Throughout Ames History, four themes prevail: a commitment to hiring the best people; cutting-edge research tools; project management that gets things done faster, better and cheaper; and outstanding research efforts that serve the scientific professions and the nation. More than any other NASA Center, Ames remains shaped by its origins in the NACA (National Advisory Committee for Aeronautics). Not that its missions remain the same. Sure, Ames still houses the world's greatest collection of wind tunnels and simulation facilities, its aerodynamicists remain among the best in the world, and pilots and engineers still come for advice on how to build better aircraft. But that is increasingly part of Ames' past. Ames people have embraced two other missions for its future. First, intelligent systems and information science will help NASA use new tools in supercomputing, networking, telepresence and robotics. Second, astrobiology will explore lore the prospects for life on Earth and beyond. Both new missions leverage Ames long-standing expertise in computation and in the life sciences, as well as its relations with the computing and biotechnology firms working in the Silicon Valley community that has sprung up around the Center. Rather than the NACA missions, it is the NACA culture that still permeates Ames. The Ames way of research management privileges the scientists and engineers working in the laboratories. They work in an atmosphere of freedom, laced with the expectation of integrity and responsibility. Ames researchers are free to define their research goals and define how they contribute to the national good. They are expected to keep their fingers on the pulse of their disciplines, to be ambitious yet frugal in organizing their efforts, and to always test their theories in the laboratory or in the field. Ames' leadership ranks, traditionally, are cultivated within this scientific community. Rather than manage and supervise these researchers, Ames leadership merely

  1. Tiger Team Assessment of the Ames Laboratory

    International Nuclear Information System (INIS)

    1992-03-01

    This report documents the Tiger Assessment of the Ames Laboratory (Ames), located in Ames, Iowa. Ames is operated for the US Department of Energy (DOE) by Iowa State University. The assessment was conducted from February 10 to March 5, 1992, under the auspices of the Office of Special Projects, Office of the Assistant Secretary of Environment, Safety and Health, Headquarters, DOE. The assessment was comprehensive, encompassing Environment, Safety, and Health (ES ampersand H) disciplines; management practices; and contractor and DOE self-assessments. Compliance with applicable Federal, State of Iowa, and local regulations; applicable DOE Orders; best management practices; and internal requirements at Ames Laboratory were assessed. In addition, an evaluation of the adequacy and effectiveness of DOE and the site contractor's management of ES ampersand H/quality assurance program was conducted

  2. Tiger Team Assessment of the Ames Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    This report documents the Tiger Assessment of the Ames Laboratory (Ames), located in Ames, Iowa. Ames is operated for the US Department of Energy (DOE) by Iowa State University. The assessment was conducted from February 10 to March 5, 1992, under the auspices of the Office of Special Projects, Office of the Assistant Secretary of Environment, Safety and Health, Headquarters, DOE. The assessment was comprehensive, encompassing Environment, Safety, and Health (ES H) disciplines; management practices; and contractor and DOE self-assessments. Compliance with applicable Federal, State of Iowa, and local regulations; applicable DOE Orders; best management practices; and internal requirements at Ames Laboratory were assessed. In addition, an evaluation of the adequacy and effectiveness of DOE and the site contractor's management of ES H/quality assurance program was conducted.

  3. Genotoxicity of 1,3-dichloro-2-propanol in the SOS chromotest and in the Ames test. Elucidation of the genotoxic mechanism.

    Science.gov (United States)

    Hahn, H; Eder, E; Deininger, C

    1991-01-01

    1,3-Dichloro-2-propanol (1,3-DCP-OH, glycerol dichlorohydrin) is of great importance in many industrial processes and has been detected in foodstuffs, in particular in soup spices and instant soups. It has been shown to be carcinogenic, genotoxic and mutagenic. Its genotoxic mechanisms are, however, not yet entirely understood. We have investigated whether alcohol dehydrogenase (ADH) catalysed activation to the highly mutagenic and carcinogenic 1,3-dichloroacetone or formation of epichlorohydrin or other genotoxic compounds play a role for mutagenicity and genotoxicity. In our studies, no indications of ADH catalysed formation of 1,3-dichloropropane could be found, although we could demonstrate a clear activation by ADH in the case of 2-chloropropenol. Formation of allyl chloride could also be excluded. We found, however, clear evidence that epichlorohydrin formed chemically in the buffer and medium used in the test is responsible for genotoxicity. No indication was found that enzymatic formation of epichlorohydrin plays a role. Additional mutagenicity and genotoxicity studies with epichlorohydrin also confirmed the hypothesis that genotoxic effects of 1,3-DCP-OH depend on the chemical formation of epichlorohydrin.

  4. The Ames Vertical Gun Range

    Science.gov (United States)

    Karcz, J. S.; Bowling, D.; Cornelison, C.; Parrish, A.; Perez, A.; Raiche, G.; Wiens, J.-P.

    2016-01-01

    The Ames Vertical Gun Range (AVGR) is a national facility for conducting laboratory- scale investigations of high-speed impact processes. It provides a set of light-gas, powder, and compressed gas guns capable of accelerating projectiles to speeds up to 7 km s(exp -1). The AVGR has a unique capability to vary the angle between the projectile-launch and gravity vectors between 0 and 90 deg. The target resides in a large chamber (diameter approximately 2.5 m) that can be held at vacuum or filled with an experiment-specific atmosphere. The chamber provides a number of viewing ports and feed-throughs for data, power, and fluids. Impacts are observed via high-speed digital cameras along with investigation-specific instrumentation, such as spectrometers. Use of the range is available via grant proposals through any Planetary Science Research Program element of the NASA Research Opportunities in Space and Earth Sciences (ROSES) calls. Exploratory experiments (one to two days) are additionally possible in order to develop a new proposal.

  5. Results of a jet plume effects test on Rockwell International integrated space shuttle vehicle using a vehicle 5 configuration 0.02-scale model (88-OTS) in the 11 by 11 foot leg of the NASA/Ames Research Center unitary plan wind tunnel (IA19), volume 1

    Science.gov (United States)

    Nichols, M. E.

    1975-01-01

    Results are presented of jet plume effects test IA19 using a vehicle 5 configuration integrated space shuttle vehicle 0.02-scale model in the NASA/Ames Research Center 11 x 11-foot leg of the unitary plan wind tunnel. The jet plume power effects on the integrated vehicle static pressure distribution were determined along with elevon, main propulsion system nozzle, and solid rocket booster nozzle effectiveness and elevon hinge moments.

  6. Ames Research Center Research and Technology 2000

    Science.gov (United States)

    2002-01-01

    This report highlights the challenging work accomplished during fiscal year 2000 by Ames research scientists,engineers, and technologists. It discusses research and technologies that enable the Information Age, that expand the frontiers of knowledge for aeronautics and space, and that help to maintain U.S. leadership in aeronautics and space research and technology development. The accomplishments are grouped into four categories based on four of NASA's Strategic Enterprises: Aerospace Technology, Space Science, Biological and Physical Research, and Earth Science. The primary purpose of this report is to communicate knowledge-to inform our stakeholders, customer, and partners, and the people of the United States about the scope and diversity of Ames' mission,the nature of Ames' research and technolog) activities,and the stimulating challenges ahead. The accomplishments cited illustrate the contributions that Ames is willing to improve the quality of life for our citizens and the economic position of the United States in the world marketplace.

  7. NASA Ames Arc Jets and Range, Capabilities for Planetary Entry

    Science.gov (United States)

    Fretter, Ernest F.

    2005-01-01

    NASA is pursuing innovative technologies and concepts as part of America's Vision for Space Exploration. The rapidly emerging field of nanotechnology has led to new concepts for multipurpose shields to prevent catastrophic loss of vehicles and crew against the triple threats of aeroheating during atmospheric entry, radiation (Solar and galactic cosmic rays) and Micrometorid/Orbital Debris (MMOD) strikes. One proposed concept is the Thermal Radiation Impact Protection System (TRIPS) using carbon nanotubes, hydrogenated carbon nanotubes, and ceramic coatings as a multi-use TPS. The Thermophysics Facilities Branch of the Space Technology Division at NASA Ames Research Center provides testing services for the development and validation of the present and future concepts being developed by NASA and national and International research firms. The Branch operates two key facilities - the Range Complex and the Arc Jets. The Ranges include both the Ames Vertical Gun Range (AVGR) and the Hypervelocity Free Flight (HFF) gas guns best suited for MMOD investigations. Test coupons can be installed in the AVGR or HFF and subjected to particle impacts from glass or metal particles from micron to _ inch (6.35-mm) diameters and at velocities from 5 to 8 kilometers per second. The facility can record high-speed data on film and provide damage assessment for analysis by the Principle Investigator or Ames personnel. Damaged articles can be installed in the Arc Jet facility for further testing to quantify the effects of damage on the heat shield s performance upon entry into atmospheric environments.

  8. Unique life sciences research facilities at NASA Ames Research Center

    Science.gov (United States)

    Mulenburg, G. M.; Vasques, M.; Caldwell, W. F.; Tucker, J.

    1994-01-01

    The Life Science Division at NASA's Ames Research Center has a suite of specialized facilities that enable scientists to study the effects of gravity on living systems. This paper describes some of these facilities and their use in research. Seven centrifuges, each with its own unique abilities, allow testing of a variety of parameters on test subjects ranging from single cells through hardware to humans. The Vestibular Research Facility allows the study of both centrifugation and linear acceleration on animals and humans. The Biocomputation Center uses computers for 3D reconstruction of physiological systems, and interactive research tools for virtual reality modeling. Psycophysiological, cardiovascular, exercise physiology, and biomechanical studies are conducted in the 12 bed Human Research Facility and samples are analyzed in the certified Central Clinical Laboratory and other laboratories at Ames. Human bedrest, water immersion and lower body negative pressure equipment are also available to study physiological changes associated with weightlessness. These and other weightlessness models are used in specialized laboratories for the study of basic physiological mechanisms, metabolism and cell biology. Visual-motor performance, perception, and adaptation are studied using ground-based models as well as short term weightlessness experiments (parabolic flights). The unique combination of Life Science research facilities, laboratories, and equipment at Ames Research Center are described in detail in relation to their research contributions.

  9. Ames Laboratory Site Environmental Report, Calendar year 1992

    International Nuclear Information System (INIS)

    1992-01-01

    The summarized data and conclusions from the Ames Laboratory environmental monitoring program are presented in this Annual Site Environmental Report. Pollution awareness and waste minimization programs and plans implemented in 1990 are continuing to date. Ames Laboratory (AL) is responsible for a small chemical burial site, located on ISU property. The site was used for the disposal of chemical and metal slags from thorium and uranium production. Samples of water from existing test wells, and upstream and downstream sites on the nearby Squaw Creek, have not detected migration of the buried materials off site. Surface, hand auger and deep boring soil samples have been collected from the site. The analytical results are pending, Six new monitoring wells have been installed and sampled. Analytical results are pending. Ames Laboratory is responsible for an area contaminated by diesel fuel that leaked from an underground storage tank (UST) in 1970. The tank was removed that year. Soil borings and groundwater have been analyzed for contamination and a preliminary assessment written. Nine small inactive waste sites have been identified for characterization. The NEPA review for this work resulted in a CX determination. The work plans were approved by AL and CH. A subcontractor has surveyed and sampled the sites. Analytical results are pending

  10. Ames Laboratory Site Environmental Report, Calendar year 1991

    International Nuclear Information System (INIS)

    Mathison, L.

    1991-01-01

    The summarized data and conclusions from the Ames Laboratory environmental monitoring program are presented in this Annual Site Environmental Report. This program is a working requirement of Department of Energy (DOE) Order 5484.1, ''Environmental Protection, Safety, and Health Protection Information Reporting Requirements'' and Order 5400.1, ''General Environmental Protection Program.'' Ames Laboratory is located on the campus of Iowa State University (ISU) and occupies several buildings owned by the DOE. The Laboratory also leases space in ISU-owned buildings. Laboratory research activities involve less than ten percent of the total chemical use and one percent of the radioisotope use on the ISU campus. Ames Laboratory is responsible for a small chemical burial site, located on ISU property. The site was used for the disposal of chemical and metal slags from thorium and uranium production. Samples of water from existing test wells and upstream and downstream sites on the nearby Squaw Creek show no detectable migration of the contents of the burial site. A Site Assessment plan submitted to the State of Iowa Department of Natural Resources (DNR) was approved. A Remedial Investigation/Feasibility Study work plan has been completed for additional studies at the site. This has been reviewed and approved by the DOE Chicago Field Office and the DNR. A National Environmental Policy Act (NEPA) review of the site resulted in a categorical exclusion finding which has been approved by the DOE. Ames Laboratory has an area contaminated by diesel fuel at the location of a storage tank which was removed in 1970. Soil corings and groundwater have been analyzed for contamination and an assessment written. Pollution awareness and waste minimization programs and plans were implemented in 1990. Included in this effort was the implementation of a waste white paper and green computer paper recycling program

  11. AmE 2012. Automotive meets electronics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    This conference CD contains 19 contributions, which were presented at the AmE 2012. The main topics were: (1) Electrification; (2) High voltage (board networks) and electromagnetic compatibility; (3) Car-to-X and driver assistance; (4) Diagnosis; (5) Electrical systems. Six contributions were recorded separately for the ENERGY database. [German] Diese Tagungs-CD enthaelt 19 Beitraege, die auf der AmE 2012 vorgestellt wurden. Die Themenschwerpunkte waren: 1. Electrification; 2. Hochvolt(-bordnetze) und Elektromagnetische Vertraeglichkeit; 3. Car-to-X und Fahrerassistenz; 4. Diagnose; 5. Bordnetze. Sechs Beitraege wurden separat fuer die ENERGY-Datenbank aufgenommen.

  12. NASA Ames Fluid Mechanics Laboratory research briefs

    Science.gov (United States)

    Davis, Sanford (Editor)

    1994-01-01

    The Ames Fluid Mechanics Laboratory research program is presented in a series of research briefs. Nineteen projects covering aeronautical fluid mechanics and related areas are discussed and augmented with the publication and presentation output of the Branch for the period 1990-1993.

  13. Results of a M = 5.3 heat transfer test of the integrated vehicle using phase-change paint techniques on the 0.0175-scale model 56-OTS in the NASA/Ames Research Center 3.5-foot hypersonic wind tunnel

    Science.gov (United States)

    Marroquin, J.

    1985-01-01

    An experimental investigation was performed in the NASA/Ames Research Center 3.5-foot Hypersonic Wind Tunnel to obtain supersonic heat-distribution data in areas between the orbiter and external tank using phase-change paint techniques. The tests used Novamide SSV Model 56-OTS in the first and second-stage ascent configurations. Data were obtained at a nominal Mach number of 5.3 and a Reynolds number per foot of 5 x 10 to the 6th power with angles of attack of 0 deg, +/- 5 deg, and sideslip angles of 0 deg and +/- 5 deg.

  14. An aerial radiological survey of the Ames Laboratory and surrounding area, Ames, Iowa

    International Nuclear Information System (INIS)

    Maurer, R.J.

    1993-04-01

    An aerial radiological survey of the Ames Laboratory and surrounding area in Ames, Iowa, was conducted during the period July 15--25, 1991. The purpose of the survey was to measure and document the terrestrial radiological environment at the Ames Laboratory and the surrounding area for use in effective environmental management and emergency response planning. The aerial survey was flown at an altitude of 200 feet (61 meters) along a series of parallel lines 350 feet (107 meters) apart. The survey encompassed an area of 36 square miles (93 square kilometers) and included the city of Ames, Iowa, and the Iowa State University. The results are reported as exposure rates at 1 meter above ground level (inferred from the aerial data) in the form of a gamma radiation contour map. Typical background exposure rates were found to vary from 7 to 9 microroentgens per hour (μR/h). No anomalous radiation levels were detected at the Ames Laboratory. However, one anomalous radiation source was detected at an industrial storage yard in the city of Ames. In support of the aerial survey, ground-based exposure rate and soil sample measurements were obtained at several sites within the survey perimeter. The results of the aerial and ground-based measurements were found to agree within the expected uncertainty of ±15%

  15. Groundwater hydrology study of the Ames Chemical Disposal Site

    International Nuclear Information System (INIS)

    Stickel, T.

    1996-01-01

    The Ames Laboratory Chemical Disposal Site is located in northwestern Ames, Iowa west of Squaw Creek. From 1957 to 1966, Ames Laboratory conducted research to develop processes to separate uranium and thorium from nuclear power fuel and to separate yttrium from neutron shielding sources. The wastes from these processes, which contained both hazardous and radiological components, were placed into nine burial pits. Metal drums, plywood boxes, and steel pails were used to store the wastes. Uranium was also burned on the ground surface of the site. Monitoring wells were placed around the waste burial pits. Groundwater testing in 1993 revealed elevated levels of Uranium 234, Uranium 238, beta and alpha radiation. The north side of the burial pit had elevated levels of volatile organic compounds. Samples in the East Ravine showed no volatile organics; however, they did contain elevated levels of radionuclides. These analytical results seem to indicate that the groundwater from the burial pit is flowing down hill and causing contamination in the East Ravine. Although there are many avenues for the contamination to spread, the focus of this project is to understand the hydrogeology of the East Ravine and to determine the path of groundwater flow down the East Ravine. The groundwater flow data along with other existing information will be used to assess the threat of chemical migration down the East Ravine and eventually off-site. The primary objectives of the project were as follows: define the geology of the East Ravine; conduct slug tests to determine the hydraulic conductivity of both oxidized and unoxidized till; develop a three-dimensional mathematical model using ModIME and MODFLOW to simulate groundwater flow in the East Ravine

  16. Air Traffic Management Research at NASA Ames

    Science.gov (United States)

    Davis, Thomas J.

    2012-01-01

    The Aviation Systems Division at the NASA Ames Research Center conducts leading edge research in air traffic management concepts and technologies. This overview will present concepts and simulation results for research in traffic flow management, safe and efficient airport surface operations, super density terminal area operations, separation assurance and system wide modeling and simulation. A brief review of the ongoing air traffic management technology demonstration (ATD-1) will also be presented. A panel discussion, with Mr. Davis serving as a panelist, on air traffic research will follow the briefing.

  17. Mutagenicity of anthraquinone and hydroxylated anthraquinones in the Ames/Salmonella microsome system.

    Science.gov (United States)

    Liberman, D F; Fink, R C; Schaefer, F L; Mulcahy, R J; Stark, A A

    1982-01-01

    The mutagenicity of anthracene, anthraquinone, and four structurally similar compounds of each was evaluated in the Ames/Salmonella microsome assay. Anthraquinone was shown to be mutagenic for strains TA1537, TA1538, and TA98 in the absence of rat liver homogenate. The four anthraquinone derivatives tested were mutagenic for TA1537 exclusively. None of the anthracenes exhibited mutagenic activity. PMID:7103489

  18. Mutagenicity of anthraquinone and hydroxylated anthraquinones in the Ames/Salmonella microsome system.

    OpenAIRE

    Liberman, D F; Fink, R C; Schaefer, F L; Mulcahy, R J; Stark, A A

    1982-01-01

    The mutagenicity of anthracene, anthraquinone, and four structurally similar compounds of each was evaluated in the Ames/Salmonella microsome assay. Anthraquinone was shown to be mutagenic for strains TA1537, TA1538, and TA98 in the absence of rat liver homogenate. The four anthraquinone derivatives tested were mutagenic for TA1537 exclusively. None of the anthracenes exhibited mutagenic activity.

  19. Static and wind tunnel near-field/far-field jet noise measurements from model scale single-flow base line and suppressor nozzles. Summary report. [conducted in the Boeing large anechoic test chamber and the NASA-Ames 40by 80-foot wind tunnel

    Science.gov (United States)

    Jaeck, C. L.

    1977-01-01

    A test program was conducted in the Boeing large anechoic test chamber and the NASA-Ames 40- by 80-foot wind tunnel to study the near- and far-field jet noise characteristics of six baseline and suppressor nozzles. Static and wind-on noise source locations were determined. A technique for extrapolating near field jet noise measurements into the far field was established. It was determined if flight effects measured in the near field are the same as those in the far field. The flight effects on the jet noise levels of the baseline and suppressor nozzles were determined. Test models included a 15.24-cm round convergent nozzle, an annular nozzle with and without ejector, a 20-lobe nozzle with and without ejector, and a 57-tube nozzle with lined ejector. The static free-field test in the anechoic chamber covered nozzle pressure ratios from 1.44 to 2.25 and jet velocities from 412 to 594 m/s at a total temperature of 844 K. The wind tunnel flight effects test repeated these nozzle test conditions with ambient velocities of 0 to 92 m/s.

  20. Ames life science telescience testbed evaluation

    Science.gov (United States)

    Haines, Richard F.; Johnson, Vicki; Vogelsong, Kristofer H.; Froloff, Walt

    1989-01-01

    Eight surrogate spaceflight mission specialists participated in a real-time evaluation of remote coaching using the Ames Life Science Telescience Testbed facility. This facility consisted of three remotely located nodes: (1) a prototype Space Station glovebox; (2) a ground control station; and (3) a principal investigator's (PI) work area. The major objective of this project was to evaluate the effectiveness of telescience techniques and hardware to support three realistic remote coaching science procedures: plant seed germinator charging, plant sample acquisition and preservation, and remote plant observation with ground coaching. Each scenario was performed by a subject acting as flight mission specialist, interacting with a payload operations manager and a principal investigator expert. All three groups were physically isolated from each other yet linked by duplex audio and color video communication channels and networked computer workstations. Workload ratings were made by the flight and ground crewpersons immediately after completing their assigned tasks. Time to complete each scientific procedural step was recorded automatically. Two expert observers also made performance ratings and various error assessments. The results are presented and discussed.

  1. AMES: Towards an Agile Method for ERP Selection

    OpenAIRE

    Juell-Skielse, Gustaf; Nilsson, Anders G.; Nordqvist, Andreas; Westergren, Mattias

    2012-01-01

    Conventional on-premise installations of ERP are now rapidly being replaced by ERP as service. Although ERP becomes more accessible and no longer requires local infrastructure, current selection methods do not take full advantage of the provided agility. In this paper we present AMES (Agile Method for ERP Selection), a novel method for ERP selection which better utilizes the strengths of service oriented ERP. AMES is designed to shorten lead time for selection, support identification of essen...

  2. The NASA Ames Life Sciences Data Archive: Biobanking for the Final Frontier

    Science.gov (United States)

    Rask, Jon; Chakravarty, Kaushik; French, Alison J.; Choi, Sungshin; Stewart, Helen J.

    2017-01-01

    The NASA Ames Institutional Scientific Collection involves the Ames Life Sciences Data Archive (ALSDA) and a biospecimen repository, which are responsible for archiving information and non-human biospecimens collected from spaceflight and matching ground control experiments. The ALSDA also manages a biospecimen sharing program, performs curation and long-term storage operations, and facilitates distribution of biospecimens for research purposes via a public website (https:lsda.jsc.nasa.gov). As part of our best practices, a tissue viability testing plan has been developed for the repository, which will assess the quality of samples subjected to long-term storage. We expect that the test results will confirm usability of the samples, enable broader science community interest, and verify operational efficiency of the archives. This work will also support NASA open science initiatives and guides development of NASA directives and policy for curation of biological collections.

  3. Consolidated Laser-Induced Fluorescence Diagnostic Systems for the NASA Ames Arc Jet Facilities

    Science.gov (United States)

    Grinstead, Jay; Wilder, Michael C.; Porter, Barry; Brown, Jeff; Yeung, Dickson; Battazzo, Steve; Brubaker, Tim

    2016-01-01

    The spectroscopic diagnostic technique of two photon absorption laser-induced fluorescence (TALIF) of atomic species for non-intrusive arc jet flow property measurement was first implemented at NASA Ames in the mid-1990s. Use of TALIF expanded at NASA Ames and to NASA Johnsons arc jet facility in the late 2000s. In 2013-2014, NASA combined the agency's large-scale arc jet test capabilities at NASA Ames. Concurrent with that effort, the agency also sponsored a project to establish two comprehensive LIF diagnostic systems for the Aerodynamic Heating Facility (AHF) and Interaction Heating Facility (IHF) arc jets. The scope of the project enabled further engineering development of the existing IHF LIF system as well as the complete reconstruction of the original AHF LIF system. The updated LIF systems are identical in design and capability. They represent the culmination of over 20 years of development experience in transitioning a specialized laboratory research tool into a measurement system for large-scale, high-demand test facilities. This paper documents the overall system design from measurement requirements to implementation. Representative data from the redeveloped AHF and IHF LIF systems are also presented.

  4. 2-Hydroxypyridine-N-oxide (HOPO): Equivocal in the ames assay.

    Science.gov (United States)

    Dobo, Krista L; Cheung, Jennifer R; Gunther, William C; Kenyon, Michelle O

    2018-05-01

    2-Hydroxypyridine-N-oxide (HOPO) is a useful coupling reagent for synthesis of active pharmaceutical ingredients. It has been reported to be weakly mutagenic in the Ames assay (Ding W et al. []: J Chromatogr A 1386:47-52). According to the ICH M7 guidance (2014) regarding control of mutagenic impurities to limit potential carcinogenic risk, mutagens require control in drug substances such that exposure not exceeds the threshold of toxicological concern. Given the weak response observed in the Ames assay and the lack of any obvious structural features that could confer DNA reactivity we were interested to determine if the results were reproducible and investigate the role of potentially confounding experimental parameters. Specifically, Ames tests were conducted to assess the influence of compound purity, solvent choice, dose spacing, toxicity, type of S9 (aroclor vs phenobarbital/β-napthoflavone), and lot variability on the frequency of HOPO induced revertant colonies. Initial extensive testing using one lot of HOPO produced no evidence of mutagenic potential in the Ames assays. Subsequent studies with four additional lots produced conflicting results, with an ∼2.0-fold increase in revertant colonies observed. Given the rigor of the current investigation, lack of reproducibility between lots, and the weak increase in revertants, it is concluded that HOPO is equivocal in the bacterial reverse mutation assay. It is highly unlikely that HOPO poses a mutagenic risk in vivo; therefore, when it is used as a reagent in pharmaceutical synthesis, it should not be regarded as a mutagenic impurity, but rather a normal process related impurity. Environ. Mol. Mutagen. 59:312-321, 2018. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

  5. The ames network and the task group on WWER's

    International Nuclear Information System (INIS)

    Davies, L.M.; Duysen, J.C. van; Estorff, U. von; Sycamore, D.

    1997-01-01

    The European Network on 'Ageing Materials Evaluation and Studies' (AMES) was created in 1993. Its main objectives are (a) to provide information and understanding on neutron irradiation effects in reactor materials in support of designers, operators, regulators and researchers and (b) to establish and discharge projects in the above areas. The Steering Committee is composed of at least one participant from each nuclear European Union country. The JRC's Institute for Advanced Materials of the European Commission plays the role of Operating Agent and Manager of the AMES Network. This paper describes the structure, objectives, and major projects of the AMES network. Particular emphasis is placed upon the work it is intended to perform within the Task Group on 'WWER's of the first AMES project (AMES1) on 'Validation of surveillance practice and mitigation methods'. EC DGXVII is addressing the question of how to facilitate contacts between EU and Russian industries in the framework of nuclear Industrial co-operation, and this project may provide a suitable starting point upon which to develop a basis for further work of mutual interest. (author)

  6. Functionally enhanced brown adipose tissue in Ames dwarf mice.

    Science.gov (United States)

    Darcy, Justin; Bartke, Andrzej

    2017-01-02

    Reduced insulin-like growth factor 1/insulin signaling (IIS) has been linked to extended longevity in species ranging from yeast to mammals. In mammals, this is exemplified in Ames dwarf (Prop1 df/df ) mice, which have a 40%-60% increase in longevity (males and females, respectively) due to their recessive Prop1 loss-of-function mutation that results in lack of growth hormone (GH), thyroid-stimulating hormone and prolactin. Our laboratory has previously shown that Ames dwarf mice have functionally unique white adipose tissue (WAT) that improves, rather than impairs, insulin sensitivity. Because GH and thyroid hormone are integral to adipose tissue development and function, we hypothesized that brown adipose tissue (BAT) in Ames dwarf mice may also be functionally unique and/or enhanced. Here, we elaborate on our recent findings, which demonstrate that BAT is functionally enhanced in Ames dwarf mice, and suggest that BAT removal in these mice results in utilization of WAT depots as an energy source. We also discuss how our findings compare to those in other long-lived dwarf mice with altered IIS, which unlike Ames dwarf mice, are essentially euthyroid. Lastly, we provide some insights into the implications of these findings and discuss some of the necessary future work in this area.

  7. Building Climate Resilience at NASA Ames Research Center

    Science.gov (United States)

    Iraci, L. T.; Mueller, C.; Podolske, J. R.; Milesi, C.

    2016-12-01

    NASA Ames Research Center, located at the southern end of the San Francisco Bay (SFB) estuary, has identified three primary vulnerabilities to changes in climate. The Ames Climate Adaptation Science Investigator (CASI) workgroup has studied each of these challenges to operations and the potential exposure of infrastructure and employees to an increased frequency of hazards. Sea level rise inundation scenarios for the SFB Area generally refer to projected scenarios in mean sea level rather than changes in extreme tides that could occur during future storm conditions. In the summer of 2014, high resolution 3-D mapping of the low-lying portion of Ames was performed. Those data are integrated with improved sea level inundation scenarios to identify the buildings, basements and drainage systems potentially affected. We will also identify the impacts of sea level and storm surge effects on transportation to and from the Center. This information will help Center management develop future master plans. Climate change will also lead to changes in temperature, storm frequency and intensity. These changes have potential impacts on localized floods and ecosystems, as well as on electricity and water availability. Over the coming decades, these changes will be imposed on top of ongoing land use and land cover changes, especially those deriving from continued urbanization and increase in impervious surface areas. These coupled changes have the potential to create a series of cascading impacts on ecosystems, including changes in primary productivity and disturbance of hydrological properties and increased flood risk. The majority of the electricity used at Ames is supplied by hydroelectric dams, which will be influenced by reductions in precipitation or changes in the timing or phase of precipitation which reduces snow pack. Coupled with increased demand for summertime air conditioning and other cooling needs, NASA Ames is at risk for electricity shortfalls. To assess the

  8. Ames and other European networks in integrity of ageing structures

    International Nuclear Information System (INIS)

    Davies, L.M.; Von Estorff, U.; Crutzen, S.

    1996-01-01

    Several European institutions and organisations and the Joint Research Centre have developed co-operative programmes now organised into Networks for mutual benefit. They include utilities, engineering companies, Research and Development laboratories and regulatory bodies. Networks are organised and managed like the successful Programme for the Inspection of Steel Components (PISC). The JRC's Institute for Advanced Materials of the European Commission plays the role of Operating Agent and manager of these Networks: ENIQ. AMES, NESC, each of them dealing with specific aspect of fitness for purpose of materials in structural components. This paper describes the structure and the objectives of these networks. Particular emphasis is given to the network AMES

  9. Ames Mutagenicity Assessment of Flavored Water Pipe Tobacco Products :A Cross Sectional Study in Tehran

    Directory of Open Access Journals (Sweden)

    Shahrzad Sadri

    2016-12-01

    Full Text Available Waterpipe smoking has become a global youth trend especially in the Middle East countries and Iran . The aim of this study was to determine the mutagenic effects of three most popular flavored tobaccos by four different salmonella typhimurium strains and compare the possible mutagenic effects of the test samples. Ames mutagenicity assessment was conducted according to the OECD guideline using TA100, TA98 , YG1024 and YG1029 strains. Charcoal burned flavored tobaccos of three different flavors including Orange, Double Apple, and Lime Mint were filtered and exposed to all strains after strain identification tests and MIC ,MBC determinations. The Ames test results indicated significant mutagenic effects of tobacco samples in all four test strains when compared with negative control (p≤0.0001. The highest Mutagenic Factor (MF was seen in Double Apple samples using TA 98 (MF=11.5±3.3 . In all experiments, TA strains showed higher sensitivity to the samples than YG strains which suggest these two strains for further regulatory toxicity tests ,policy making purposes and tobacco control programs . Present results represents an important step in understanding the genotoxic potentials of three most popular flavored tobaccos samples of a famous brand in the global markets .

  10. Developing questionnaires for educational research: AMEE Guide No. 87

    Science.gov (United States)

    La Rochelle, Jeffrey S.; Dezee, Kent J.; Gehlbach, Hunter

    2014-01-01

    In this AMEE Guide, we consider the design and development of self-administered surveys, commonly called questionnaires. Questionnaires are widely employed in medical education research. Unfortunately, the processes used to develop such questionnaires vary in quality and lack consistent, rigorous standards. Consequently, the quality of the questionnaires used in medical education research is highly variable. To address this problem, this AMEE Guide presents a systematic, seven-step process for designing high-quality questionnaires, with particular emphasis on developing survey scales. These seven steps do not address all aspects of survey design, nor do they represent the only way to develop a high-quality questionnaire. Instead, these steps synthesize multiple survey design techniques and organize them into a cohesive process for questionnaire developers of all levels. Addressing each of these steps systematically will improve the probabilities that survey designers will accurately measure what they intend to measure. PMID:24661014

  11. Ames Laboratory annual site environmental report, calendar year 1996

    International Nuclear Information System (INIS)

    1998-04-01

    This report summarizes the environmental status of Ames Laboratory for calendar year 1996. It includes descriptions of the Laboratory site, its mission, the status of its compliance with applicable environmental regulations, its planning and activities to maintain compliance, and a comprehensive review of its environmental protection, surveillance and monitoring programs. Ames Laboratory is located on the campus of Iowa State University (ISU) and occupies twelve buildings owned by the Department of Energy (DOE). The Laboratory also leases space in ISU owned buildings. Laboratory activities involve less than ten percent of the total chemical use and approximately one percent of the radioisotope use on the ISU campus. In 1996, the Office of Assurance and Assessment merged with the Environment, Safety and Health Group forming the Environment, Safety, Health and Assurance (ESH and A) office. In 1996, the Laboratory accumulated and disposed of wastes under US Environmental Protection Agency (EPA) issued generator numbers. Ames Laboratory submitted a Proposed Site Treatment Plan to EPA in December 1995. This plan complied with the Federal Facilities Compliance Act (FFCA). It was approved by EPA in January 1996. The consent agreement/consent order was issued in February 1996. Pollution awareness, waste minimization and recycling programs, implemented in 1990 and updated in 1994, continued through 1996. Included in these efforts were a waste white paper and green computer paper recycling program. Ames Laboratory also continued to recycle salvageable metal and used oil, and it recovered freon for recycling. All of the chemical and nearly all of the radiological legacy wastes were properly disposed by the end of 1996. Additional radiological legacy waste will be properly disposed during 1997

  12. Phospholipid composition and longevity: lessons from Ames dwarf mice.

    Science.gov (United States)

    Valencak, Teresa G; Ruf, Thomas

    2013-12-01

    Membrane fatty acid (FA) composition is correlated with longevity in mammals. The "membrane pacemaker hypothesis of ageing" proposes that animals which cellular membranes contain high amounts of polyunsaturated FAs (PUFAs) have shorter life spans because their membranes are more susceptible to peroxidation and further oxidative damage. It remains to be shown, however, that long-lived phenotypes such as the Ames dwarf mouse have membranes containing fewer PUFAs and thus being less prone to peroxidation, as would be predicted from the membrane pacemaker hypothesis of ageing. Here, we show that across four different tissues, i.e., muscle, heart, liver and brain as well as in liver mitochondria, Ames dwarf mice possess membrane phospholipids containing between 30 and 60 % PUFAs (depending on the tissue), which is similar to PUFA contents of their normal-sized, short-lived siblings. However, we found that that Ames dwarf mice membrane phospholipids were significantly poorer in n-3 PUFAs. While lack of a difference in PUFA contents is contradicting the membrane pacemaker hypothesis, the lower n-3 PUFAs content in the long-lived mice provides some support for the membrane pacemaker hypothesis of ageing, as n-3 PUFAs comprise those FAs being blamed most for causing oxidative damage. By comparing tissue composition between 1-, 2- and 6-month-old mice in both phenotypes, we found that membranes differed both in quantity of PUFAs and in the prevalence of certain PUFAs. In sum, membrane composition in the Ames dwarf mouse supports the concept that tissue FA composition is related to longevity.

  13. Is the Moon Illusion a Celestial Ames Demonstration?

    Science.gov (United States)

    Brecher, Kenneth

    2010-01-01

    To most naked eye observers, the Moon appears larger when seen near the horizon than it does when seen near the zenith. This "Moon Illusion” has been reported from as early as the fourth century BC and has been the subject of hundreds of papers and two books. Its explanation does not lie in the realm of physics (atmospheric refraction) or astronomy (eccentric lunar orbit) but, rather, in the realm of visual perception. Theories for the cause of the effect abound but, at present, there is no universally accepted explanation. Because the effect can be easily observed in many locations and during the course of an academic year, the moon illusion can provide a nice astronomical example that involves both direct observations and theoretical analysis. As part of the NSF funded "Project LITE: Light Inquiry Through Experiments", we have been developing inexpensive experiments and demonstrations that can be done at home. One of these is a miniature version of the classic "Ames Room". The life size version was originally developed by Adelbert Ames, Jr. and can be seen in many science museums. Our "digital” Ames Room has been designed to be printed on heavy paper using an inexpensive inkjet printer from a PDF file that is posted on the Project LITE web site http://lite.bu.edu and then cut and folded to make the room. When viewed through one wall using a commonly available door viewer, it dramatically demonstrates how the eye and brain system assesses the relative size of objects by making comparisons with the surrounding environment in which the objects are placed. In this presentation we will discuss some insights that the Ames Room provides that may offer clues to the correct explanation for the Moon Illusion. Project LITE is supported by the NSF through DUE Grant # 0715975.

  14. The AMES network strategy developments within and outside the EU

    International Nuclear Information System (INIS)

    Sevini, F.; Debarberis, L.; Davies, L.M.; English, C.

    2001-01-01

    The AMES (Ageing Materials Evaluation and Studies) network started its activity in 1993 with the aim of studying the consequences and the mechanisms of the ageing process in materials used for nuclear reactor components. Together with ENIQ, NESC, EPERC, it forms the so-called ''Structural Integrity of Industrial Components'' cluster of networks operated by the Joint Research Centre - Institute for Advanced Materials of the European Commission. After two initial phases dedicated to the compilation of state-of-the-art reports on non-destructive monitoring techniques for thermal ageing, dosimetry, survey of regulatory requirements, predictive formulas for irradiation embrittlement, AMES has entered its third strategy phase with the fifth EURATOM Framework Program, Nuclear Fission Safety Key Action. Most of the projects proposed for this program and sustained by the Steering committee were selected for funding. Their focus is on the influence of chemical composition, namely phosphorus and nickel content, on the irradiation embrittlement of reactor pressure vessel materials, on the improvement of surveillance temperature measurement, on the validation of the Master Curve approach, and on ND techniques to monitor ageing of irradiated steels. The paper describes the objectives of the new fifth Framework Program projects and how they are part of the AMES strategy, pointing out the involvement of CEEC and NIS countries. (authors)

  15. Voluntary cleanup of the Ames chemical disposal site

    International Nuclear Information System (INIS)

    Taboas, A.L.; Freeman, R.; Peterson, J.

    2003-01-01

    The U.S. Department of Energy completed a voluntary removal action at the Ames chemical disposal site, a site associated with the early days of the Manhattan Project. It contained chemical and low-level radioactive wastes from development of the technology to extract uranium from uranium oxide. The process included the preparation of a Remedial Investigation, Feasibility Study, Baseline Risk Assessment, and, ultimately, issuance of a Record of Decision. Various stakeholder groups were involved, including members of the regulatory community, the general public, and the landowner, Iowa State University. The site was restored and returned to the landowner for unrestricted use.

  16. Reduction of Background Noise in the NASA Ames 40- by 80-Foot Wind Tunnel

    Science.gov (United States)

    Jaeger, Stephen M.; Allen, Christopher S.; Soderman, Paul T.; Olson, Larry E. (Technical Monitor)

    1995-01-01

    Background noise in both open-jet and closed wind tunnels adversely affects the signal-to-noise ratio of acoustic measurements. To measure the noise of increasingly quieter aircraft models, the background noise will have to be reduced by physical means or through signal processing. In a closed wind tunnel, such as the NASA Ames 40- by 80- Foot Wind Tunnel, the principle background noise sources can be classified as: (1) fan drive noise; (2) microphone self-noise; (3) aerodynamically induced noise from test-dependent hardware such as model struts and junctions; and (4) noise from the test section walls and vane set. This paper describes the steps taken to minimize the influence of each of these background noise sources in the 40 x 80.

  17. The AMES network in the 6th Framework Programme

    International Nuclear Information System (INIS)

    Sevini, F.; Debarberis, L.; Taylor, N.; Gerard, R.; English, C.; Brumovsky, M.

    2003-01-01

    The AMES (Ageing Materials European Strategy) European network started its activity in 1993 with the aim of studying ageing mechanisms and remedial procedures for structural materials used for nuclear reactor components. Operated by JRC-IE, it has been supporting the co-ordination of the project cluster throughout the 4th and 5th EURATOM Framework Programs, carrying out projects on with plant life management implications. Among them we can list the development of non-destructive techniques applied to thermal ageing and neutron embrittlement monitoring (AMES-NDT and GRETE), improved surveillance for VVER 440 reactors (COBRA), dosimetry (AMESDOSIMETRY, MADAM and REDOS), chemical composition effects on neutron embrittlement (PISA) and advanced fracture mechanics for integrity assessment (FRAME). Main frame of the network in the 5th Framework Programme is the ATHENA project, which is aimed at summarizing the obtained achievements and edit guidelines on important issues like the Master Curve, Effect of chemical composition on embrittlement rate in RPV steels, Re-embrittlement models validation after VVER-440 annealing and open issues in embrittlement of VVER type reactors. In the 6th EURATOM Framework Programme started in 2003 the network will be part of a broader initiative on PLIM including in a more integrated way NESC, ENIQ, NET and AMALIA networks. This paper shows an overview of the concluded projects, achievements of the running ones and open issues tackled in the 6th EURATOM FWP and a summary of the plans for a new broader network on NPP Plant Life management (SAFELIFE). (author)

  18. Penentuan Titik Lokasi Pelabuhan Penyeberangan Amed Di Kabupaten Karangasem

    Directory of Open Access Journals (Sweden)

    I Gusti Ngurah Putra Dirgayusa

    2016-07-01

    Full Text Available Accumulation of social activity, economy and transportation that occur in Southern part of Bali adversely affects at transportation infrastructure carrying activity in this area. These require the government to get the solution of this problem. Through spatial planning area of Bali province 2005, governments establish Amed Bay developed as crossing harbor. These cases mean to divide the shout hem traffic line and support the development in northern part of Bali. The object of this research is in Purwakerti village, district of Abang, Karangasem regency. Research held based on technical and legality review. In advance analyze of those aspects that established some alterative potential location based on area requirement and mapping survey result. Following, each location alternative disassembly and examined their advantages and disadvantages in each aspect. Technical aspect analyze of land and territorial water technique. The approach that used in harbor location selection for this technique is weighting and assessment method in assessment matrix. The weighting value that used refers to harbor location selection in Makian bay. Meanwhile, for legality aspect, analyzed by policy review that relate to spatial area and location selection of harbor development. Based on minimum area demand analyze that 0.7 Ha for land facilities and 15.8 Ha for waters facilities. Refers to minimum area demand and layout spatial survey, four locations are selected for alternative points. After technical and legality aspect analyzed, then obtained second area chosen which located in Amed country, Purwakerti village.

  19. A Perspective on NASA Ames Air Traffic Management Research

    Science.gov (United States)

    Schroeder, Jeffery A.

    2012-01-01

    This paper describes past and present air-traffic-management research at NASA Ames Research Center. The descriptions emerge from the perspective of a technical manager who supervised the majority of this research for the last four years. Past research contributions built a foundation for calculating accurate flight trajectories to enable efficient airspace management in time. That foundation led to two predominant research activities that continue to this day - one in automatically separating aircraft and the other in optimizing traffic flows. Today s national airspace uses many of the applications resulting from research at Ames. These applications include the nationwide deployment of the Traffic Management Advisor, new procedures enabling continuous descent arrivals, cooperation with industry to permit more direct flights to downstream way-points, a surface management system in use by two cargo carriers, and software to evaluate how well flights conform to national traffic management initiatives. The paper concludes with suggestions for prioritized research in the upcoming years. These priorities include: enabling more first-look operational evaluations, improving conflict detection and resolution for climbing or descending aircraft, and focusing additional attention on the underpinning safety critical items such as a reliable datalink.

  20. NASA Ames Sustainability Initiatives: Aeronautics, Space Exploration, and Sustainable Futures

    Science.gov (United States)

    Grymes, Rosalind A.

    2015-01-01

    In support of the mission-specific challenges of aeronautics and space exploration, NASA Ames produces a wealth of research and technology advancements with significant relevance to larger issues of planetary sustainability. NASA research on NexGen airspace solutions and its development of autonomous and intelligent technologies will revolutionize both the nation's air transporation systems and have applicability to the low altitude flight economy and to both air and ground transporation, more generally. NASA's understanding of the Earth as a complex of integrated systems contributes to humanity's perception of the sustainability of our home planet. Research at NASA Ames on closed environment life support systems produces directly applicable lessons on energy, water, and resource management in ground-based infrastructure. Moreover, every NASA campus is a 'city'; including an urbanscape and a workplace including scientists, human relations specialists, plumbers, engineers, facility managers, construction trades, transportation managers, software developers, leaders, financial planners, technologists, electricians, students, accountants, and even lawyers. NASA is applying the lessons of our mission-related activities to our urbanscapes and infrastructure, and also anticipates a leadership role in developing future environments for living and working in space.

  1. Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice

    Science.gov (United States)

    McFadden, Samuel; Fang, Yimin; Huber, Joshua A.; Zhang, Chi; Sun, Liou Y.; Bartke, Andrzej

    2016-01-01

    Ames dwarf mice (Prop1df/df) are long-lived due to a loss of function mutation, resulting in deficiency of GH, TSH, and prolactin. Along with a marked extension of longevity, Ames dwarf mice have improved energy metabolism as measured by an increase in their oxygen consumption and heat production, as well as a decrease in their respiratory quotient. Along with alterations in energy metabolism, Ames dwarf mice have a lower core body temperature. Moreover, Ames dwarf mice have functionally altered epididymal white adipose tissue (WAT) that improves, rather than impairs, their insulin sensitivity due to a shift from pro- to anti-inflammatory cytokine secretion. Given the unique phenotype of Ames dwarf epididymal WAT, their improved energy metabolism, and lower core body temperature, we hypothesized that Ames dwarf brown adipose tissue (BAT) may function differently from that of their normal littermates. Here we use histology and RT-PCR to demonstrate that Ames dwarf mice have enhanced BAT function. We also use interscapular BAT removal to demonstrate that BAT is necessary for Ames dwarf energy metabolism and thermogenesis, whereas it is less important for their normal littermates. Furthermore, we show that Ames dwarf mice are able to compensate for loss of interscapular BAT by using their WAT depots as an energy source. These findings demonstrate enhanced BAT function in animals with GH and thyroid hormone deficiencies, chronic reduction of body temperature, and remarkably extended longevity. PMID:27740871

  2. The NASA Ames Research Center Institutional Scientific Collection: History, Best Practices and Scientific Opportunities

    Science.gov (United States)

    Rask, Jon C.; Chakravarty, Kaushik; French, Alison; Choi, Sungshin; Stewart, Helen

    2017-01-01

    The NASA Ames Life Sciences Institutional Scientific Collection (ISC), which is composed of the Ames Life Sciences Data Archive (ALSDA) and the Biospecimen Storage Facility (BSF), is managed by the Space Biosciences Division and has been operational since 1993. The ALSDA is responsible for archiving information and animal biospecimens collected from life science spaceflight experiments and matching ground control experiments. Both fixed and frozen spaceflight and ground tissues are stored in the BSF within the ISC. The ALSDA also manages a Biospecimen Sharing Program, performs curation and long-term storage operations, and makes biospecimens available to the scientific community for research purposes via the Life Science Data Archive public website (https:lsda.jsc.nasa.gov). As part of our best practices, a viability testing plan has been developed for the ISC, which will assess the quality of archived samples. We expect that results from the viability testing will catalyze sample use, enable broader science community interest, and improve operational efficiency of the ISC. The current viability test plan focuses on generating disposition recommendations and is based on using ribonucleic acid (RNA) integrity number (RIN) scores as a criteria for measurement of biospecimen viablity for downstream functional analysis. The plan includes (1) sorting and identification of candidate samples, (2) conducting a statiscally-based power analysis to generate representaive cohorts from the population of stored biospecimens, (3) completion of RIN analysis on select samples, and (4) development of disposition recommendations based on the RIN scores. Results of this work will also support NASA open science initiatives and guides development of the NASA Scientific Collections Directive (a policy on best practices for curation of biological collections). Our RIN-based methodology for characterizing the quality of tissues stored in the ISC since the 1980s also creates unique

  3. Uji Mutagenik Ames untuk Melengkapi Data Keamanan Ekstrak Gambir (Uncaria gambir Roxb.

    Directory of Open Access Journals (Sweden)

    Novi Sulistyaningrum

    2015-05-01

    Full Text Available The main compound of Uncaria gambir Roxb. (gambir, catechin and it’s derivates have been believed to be potential as antiviral. Epigallocatechin gallate (EGCG and epicatechin are catechin derivates which are found to be potential as antiviral against Human Immunodeficiency Virus (HIV. However, gambir extract also contains quercetin that has possibility to be mutagenic. Therefore, a preliminary study towards safety of those compounds within gambir extract, mutagenicity assay using Ames Method has been performed.Sample (gambir extract was obtained from West Sumatera, Indonesia. The extract was characterized according to Farmakope Herbal Indonesia and WHO methods. Mutagenicity test by Ames method utilized a colorimetric microplate in 6 various concentration (125 mg/mL; 62.5 mg/mL; 31.25 mg/mL; 15.625 mg/mL; 7.81 mg/mL dan 3.91 mg/mL against mutant bacteria Salmonella typhimurium TA 98, Salmonella typhimurium TA 100 and Escherichia coli WP2 uvrA with and without the addition of S-9 enzyme. Extract of gambir in this study contains 86.60% of catechin, 12.92% moisture content, 22.49% water-soluble extract content, 80.63% ethanol-soluble extract content, 0.81% total ash, 0.32% acid insoluble ash content and 10.38% in dryness level. From the mutagenicity test and calculation, fold increase (over baseline of the sample in 6 various concentration with and without adding S-9 enzyme are lower than 2. Gambir extract from West Sumatra with catechin contains 86.6% hasn’t showed mutagenic effect due to the fold increase (over baseline of mutagenicity test lower than 2.

  4. THE NASA AMES POLYCYCLIC AROMATIC HYDROCARBON INFRARED SPECTROSCOPIC DATABASE: THE COMPUTED SPECTRA

    International Nuclear Information System (INIS)

    Bauschlicher, C. W.; Ricca, A.; Boersma, C.; Mattioda, A. L.; Cami, J.; Peeters, E.; Allamandola, L. J.; Sanchez de Armas, F.; Puerta Saborido, G.; Hudgins, D. M.

    2010-01-01

    The astronomical emission features, formerly known as the unidentified infrared bands, are now commonly ascribed to polycyclic aromatic hydrocarbons (PAHs). The laboratory experiments and computational modeling done at the NASA Ames Research Center to create a collection of PAH IR spectra relevant to test and refine the PAH hypothesis have been assembled into a spectroscopic database. This database now contains over 800 PAH spectra spanning 2-2000 μm (5000-5 cm -1 ). These data are now available on the World Wide Web at www.astrochem.org/pahdb. This paper presents an overview of the computational spectra in the database and the tools developed to analyze and interpret astronomical spectra using the database. A description of the online and offline user tools available on the Web site is also presented.

  5. Scientific visualization in computational aerodynamics at NASA Ames Research Center

    Science.gov (United States)

    Bancroft, Gordon V.; Plessel, Todd; Merritt, Fergus; Walatka, Pamela P.; Watson, Val

    1989-01-01

    The visualization methods used in computational fluid dynamics research at the NASA-Ames Numerical Aerodynamic Simulation facility are examined, including postprocessing, tracking, and steering methods. The visualization requirements of the facility's three-dimensional graphical workstation are outlined and the types hardware and software used to meet these requirements are discussed. The main features of the facility's current and next-generation workstations are listed. Emphasis is given to postprocessing techniques, such as dynamic interactive viewing on the workstation and recording and playback on videodisk, tape, and 16-mm film. Postprocessing software packages are described, including a three-dimensional plotter, a surface modeler, a graphical animation system, a flow analysis software toolkit, and a real-time interactive particle-tracer.

  6. Applied Computational Fluid Dynamics at NASA Ames Research Center

    Science.gov (United States)

    Holst, Terry L.; Kwak, Dochan (Technical Monitor)

    1994-01-01

    The field of Computational Fluid Dynamics (CFD) has advanced to the point where it can now be used for many applications in fluid mechanics research and aerospace vehicle design. A few applications being explored at NASA Ames Research Center will be presented and discussed. The examples presented will range in speed from hypersonic to low speed incompressible flow applications. Most of the results will be from numerical solutions of the Navier-Stokes or Euler equations in three space dimensions for general geometry applications. Computational results will be used to highlight the presentation as appropriate. Advances in computational facilities including those associated with NASA's CAS (Computational Aerosciences) Project of the Federal HPCC (High Performance Computing and Communications) Program will be discussed. Finally, opportunities for future research will be presented and discussed. All material will be taken from non-sensitive, previously-published and widely-disseminated work.

  7. Ames Laboratory site environmental report, Calendar year 1994

    International Nuclear Information System (INIS)

    1994-01-01

    The Ames Laboratory conducts fundamental research in the physical, chemical, materials, and mathematical sciences and engineering which underlie energy generating, conversion, transmission and storage technologies, environmental improvement, and other technical areas essential to national needs. These efforts will be maintained so as to contribute to the achievement of the vision of DOE and, more specifically, to increase the general levels of knowledge and technical capabilities, to prepare engineering and physical sciences students for the future, both academia and industry, and to develop new technologies and practical applications from our basic scientific programs that will contribute to a strengthening of the US economy. The Laboratory approaches all its operations with the safety and health of all workers as a constant objective and with genuine concern for the environment. The Laboratory relies upon its strengths in materials synthesis and processing, materials reliability, chemical analysis, chemical sciences, photosynthesis, materials sciences, metallurgy, high-temperature superconductivity, and applied mathematical sciences to conduct the long term basic and intermediate range applied research needed to solve the complex problems encountered in energy production, and utilization as well as environmental restoration and waste management. Ames Laboratory will continue to maintain a very significant and highly beneficial pre-college math and science education program which currently serves both teachers and students at the middle school and high school levels. Our technology transfer program is aided by joint efforts with ISU's technology development and commercialization enterprise and will sustain concerted efforts to implement Cooperative Research and Development Agreements, industrially sponsored Work for Others projects. and scientific personnel exchanges with our various customers

  8. Wind Tunnel Testing Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — NASA Ames Research Center is pleased to offer the services of our premier wind tunnel facilities that have a broad range of proven testing capabilities to customers...

  9. Sources and levels of background noise in the NASA Ames 40- by 80-foot wind tunnel

    Science.gov (United States)

    Soderman, Paul T.

    1988-01-01

    Background noise levels are measured in the NASA Ames Research Center 40- by 80-Foot Wind Tunnel following installation of a sound-absorbent lining on the test-section walls. Results show that the fan-drive noise dominated the empty test-section background noise at airspeeds below 120 knots. Above 120 knots, the test-section broadband background noise was dominated by wind-induced dipole noise (except at lower harmonics of fan blade-passage tones) most likely generated at the microphone or microphone support strut. Third-octave band and narrow-band spectra are presented for several fan operating conditions and test-section airspeeds. The background noise levels can be reduced by making improvements to the microphone wind screen or support strut. Empirical equations are presented relating variations of fan noise with fan speed or blade-pitch angle. An empirical expression for typical fan noise spectra is also presented. Fan motor electric power consumption is related to the noise generation. Preliminary measurements of sound absorption by the test-section lining indicate that the 152 mm thick lining will adequately absorb test-section model noise at frequencies above 300 Hz.

  10. (New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Here he welcomes

    Science.gov (United States)

    2002-01-01

    (New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Here he welcomes JASON kids to NASA while handing out patches and pins. Tom Clausen and Donald James, Ames Education Office in background.

  11. (New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Meets with

    Science.gov (United States)

    2002-01-01

    (New) NASA Administrator Sean O'Keefe comes to Ames for employee briefing and tour. Meets with Roberto Cruz, National Hispanic University (left) at Amesto sign the educational MOU between NHU and Ames.

  12. Sixth Annual NASA Ames Space Science and Astrobiology Jamboree

    Science.gov (United States)

    Hollingsworth, Jeffery; Howell, Steve; Fonda, Mark; Dateo, Chris; Martinez, Christine M.

    2018-01-01

    Welcome to the Sixth Annual NASA Ames Research Center, Space Science and Astrobiology Jamboree at NASA Ames Research Center (ARC). The Space Science and Astrobiology Division consists of over 60 Civil Servants, with more than 120 Cooperative Agreement Research Scientists, Post-Doctoral Fellows, Science Support Contractors, Visiting Scientists, and many other Research Associates. Within the Division there is engagement in scientific investigations over a breadth of disciplines including Astrobiology, Astrophysics, Exobiology, Exoplanets, Planetary Systems Science, and many more. The Division's personnel support NASA spacecraft missions (current and planned), including SOFIA, K2, MSL, New Horizons, JWST, WFIRST, and others. Our top-notch science research staff is spread amongst three branches in five buildings at ARC. Naturally, it can thus be difficult to remain abreast of what fellow scientific researchers pursue actively, and then what may present and/or offer regarding inter-Branch, intra-Division future collaborative efforts. In organizing this annual jamboree, the goals are to offer a wholesome, one-venue opportunity to sense the active scientific research and spacecraft mission involvement within the Division; and to facilitate communication and collaboration amongst our research scientists. Annually, the Division honors one senior research scientist with a Pollack Lecture, and one early career research scientist with an Outstanding Early Career Space Scientist Lecture. For the Pollack Lecture, the honor is bestowed upon a senior researcher who has made significant contributions within any area of research aligned with space science and/or astrobiology. This year we are pleased to honor Linda Jahnke. With the Early Career Lecture, the honor is bestowed upon an early-career researcher who has substantially demonstrated great promise for significant contributions within space science, astrobiology, and/or, in support of spacecraft missions addressing such

  13. (New) NASA Director Sean O'Keefe comes to Ames for employee briefing and tour. Meets with Roberto

    Science.gov (United States)

    2002-01-01

    (New) NASA Director Sean O'Keefe comes to Ames for employee briefing and tour. Meets with Roberto Cruz, National Hispanic University (seated, right) and Ames Center Director Dr. Henry McDonald follow the signing of the educational MOU between NHU and Ames.

  14. Model Deformation and Optical Angle of Attack Measurement System in the NASA Ames Unitary Plan Wind Tunnel

    Science.gov (United States)

    Kushner, Laura K.; Drain, Bethany A.; Schairer, Edward T.; Heineck, James T.; Bell, James H.

    2017-01-01

    Both AoA and MDM measurements can be made using an optical system that relies on photogrammetry. Optical measurements are being requested by customers in wind tunnels with increasing frequency due to their non-intrusive nature and recent hardware and software advances that allow measurements to become near real time. The NASA Ames Research Center Unitary Plan Wind Tunnel is currently developing a system based on photogrammetry to measure model deformation and model angle of attack. This paper describes the new system, its development, its use on recent tests and plans to further develop the system.

  15. NASA Ames Research Center 60 MW Power Supply Modernization

    Science.gov (United States)

    Choy, Yuen Ching; Ilinets, Boris V.; Miller, Ted; Nagel, Kirsten (Technical Monitor)

    2001-01-01

    The NASA Ames Research Center 60 MW DC Power Supply was built in 1974 to provide controlled DC power for the Thermophysics Facility Arc Jet Laboratory. The Power Supply has gradually losing reliability due to outdated technology and component life limitation. NASA has decided to upgrade the existing rectifier modules with contemporary high-power electronics and control equipment. NASA plans to complete this project in 2001. This project includes a complete replacement of obsolete thyristor stacks in all six rectifier modules and rectifier bridge control system. High power water-cooled thyristors and freewheeling diodes will be used. The rating of each of the six modules will be 4000 A at 5500 V. The control firing angle signal will be sent from the Facility Control System to six modules via fiberoptic cable. The Power Supply control and monitoring system will include a Master PLC in the Facility building and a Slave PLC in each rectifier module. This system will also monitor each thyristor level in each stack and the auxiliary equipment.

  16. Ethnography in qualitative educational research: AMEE Guide No. 80.

    Science.gov (United States)

    Reeves, Scott; Peller, Jennifer; Goldman, Joanne; Kitto, Simon

    2013-08-01

    Ethnography is a type of qualitative research that gathers observations, interviews and documentary data to produce detailed and comprehensive accounts of different social phenomena. The use of ethnographic research in medical education has produced a number of insightful accounts into its role, functions and difficulties in the preparation of medical students for clinical practice. This AMEE Guide offers an introduction to ethnography - its history, its differing forms, its role in medical education and its practical application. Specifically, the Guide initially outlines the main characteristics of ethnography: describing its origins, outlining its varying forms and discussing its use of theory. It also explores the role, contribution and limitations of ethnographic work undertaken in a medical education context. In addition, the Guide goes on to offer a range of ideas, methods, tools and techniques needed to undertake an ethnographic study. In doing so it discusses its conceptual, methodological, ethical and practice challenges (e.g. demands of recording the complexity of social action, the unpredictability of data collection activities). Finally, the Guide provides a series of final thoughts and ideas for future engagement with ethnography in medical education. This Guide is aimed for those interested in understanding ethnography to develop their evaluative skills when reading such work. It is also aimed at those interested in considering the use of ethnographic methods in their own research work.

  17. Mobile technologies in medical education: AMEE Guide No. 105.

    Science.gov (United States)

    Masters, Ken; Ellaway, Rachel H; Topps, David; Archibald, Douglas; Hogue, Rebecca J

    2016-06-01

    Mobile technologies (including handheld and wearable devices) have the potential to enhance learning activities from basic medical undergraduate education through residency and beyond. In order to use these technologies successfully, medical educators need to be aware of the underpinning socio-theoretical concepts that influence their usage, the pre-clinical and clinical educational environment in which the educational activities occur, and the practical possibilities and limitations of their usage. This Guide builds upon the previous AMEE Guide to e-Learning in medical education by providing medical teachers with conceptual frameworks and practical examples of using mobile technologies in medical education. The goal is to help medical teachers to use these concepts and technologies at all levels of medical education to improve the education of medical and healthcare personnel, and ultimately contribute to improved patient healthcare. This Guide begins by reviewing some of the technological changes that have occurred in recent years, and then examines the theoretical basis (both social and educational) for understanding mobile technology usage. From there, the Guide progresses through a hierarchy of institutional, teacher and learner needs, identifying issues, problems and solutions for the effective use of mobile technology in medical education. This Guide ends with a brief look to the future.

  18. The NASA Ames Hypersonic Combustor-Model Inlet CFD Simulations and Experimental Comparisons

    Science.gov (United States)

    Venkatapathy, E.; Tokarcik-Polsky, S.; Deiwert, G. S.; Edwards, Thomas A. (Technical Monitor)

    1995-01-01

    Computations have been performed on a three-dimensional inlet associated with the NASA Ames combustor model for the hypersonic propulsion experiment in the 16-inch shock tunnel. The 3-dimensional inlet was designed to have the combustor inlet flow nearly two-dimensional and of sufficient mass flow necessary for combustion. The 16-inch shock tunnel experiment is a short duration test with test time of the order of milliseconds. The flow through the inlet is in chemical non-equilibrium. Two test entries have been completed and limited experimental results for the inlet region of the combustor-model are available. A number of CFD simulations, with various levels of simplifications such as 2-D simulations, 3-D simulations with and without chemical reactions, simulations with and without turbulent conditions, etc., have been performed. These simulations have helped determine the model inlet flow characteristics and the important factors that affect the combustor inlet flow and the sensitivity of the flow field to these simplifications. In the proposed paper, CFD modeling of the hypersonic inlet, results from the simulations and comparison with available experimental results will be presented.

  19. Making Stuff Outreach at the Ames Laboratory and Iowa State University

    Energy Technology Data Exchange (ETDEWEB)

    Ament, Katherine; Karsjen, Steven; Leshem-Ackerman, Adah; King, Alexander

    2011-04-01

    The U. S. Department of Energy's Ames Laboratory in Ames, Iowa was a coalition partner for outreach activities connected with NOVA's Making Stuff television series on PBS. Volunteers affiliated with the Ames Laboratory and Iowa State University, with backgrounds in materials science, took part in activities including a science-themed Family Night at a local mall, Science Cafes at the Science Center of Iowa, teacher workshops, demonstrations at science nights in elementary and middle schools, and various other events. We describe a selection of the activities and present a summary of their outcomes and extent of their impact on Ames, Des Moines and the surrounding communities in Iowa. In Part 2, results of a volunteer attitude survey are presented, which shed some light on the volunteer experience and show how the volunteers participation in outreach activities has affected their views of materials education.

  20. Acquisition of steady-state operant behavior in long-living Ames Dwarf mice.

    Science.gov (United States)

    Derenne, Adam; Brown-Borg, Holly; Feltman, Kathryn; Corbett, Grant; Lackman, Serena

    2011-10-24

    Ames dwarf mice have a Prop-1 mutation that has been identified with increased levels of IGF-I in the central nervous system, upregulation of neuroprotective systems, and increased lifespan. To elucidate the behavioral effects of the Prop-1 mutation, 8 Ames dwarf and 7 normal mice (all of whom were 8 months of age or younger) were compared on a differential-reinforcement-of-low-rate-of-responding schedule of reinforcement and a matching-to-sample task. On both tasks, nosepokes were reinforced with access to a saccharin solution. Comparisons were based on several measures of behavioral efficiency: pause durations, intertrial intervals, and numbers of responses. Ames dwarf mice were generally less efficient than normal mice. One possible cause of this outcome is that relatively young Ames dwarf mice show less cognitive development than age-matched normal mice. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Analysis of Hexanitrostilbene (HNS) and Dipicryethane (DPE) for Mutagenicity by the Ames/Salmonella Assay

    Energy Technology Data Exchange (ETDEWEB)

    Wu, R; Felton, J

    2007-10-12

    The Ames/Salmonella assay, developed by Professor Bruce Ames at the University of California, Berkeley, is a rapid and sensitive assay for detecting mutagenicity of various chemical compounds (Maron and Ames, 1983). It is a widely accepted short-term assay for detecting chemicals that induce mutations in the histidine (his) gene of Salmonella typhimurium. This is a reverse mutation assay that detects the mutational reversion of his-dependent Salmonella to the his-independent counterpart. Thereby, mutagenic compounds will increase the frequency of occurrence of his-independent bacterial colonies. The assay utilizes the specific genetically constructed strains of bacteria either with or without mammalian metabolic activation enzymes (S9), Aroclor induced rat liver homogenate to assess the mutagenicity of different compounds. In this study, we will use the Ames/Salmonella assay to investigate the mutagenicity of Hexanitrostilbene (HNS) from both Bofors and Pantex, and Dipicryethane (DPE).

  2. 3rd Annual NASA Ames Space Science and Astrobiology Jamboree

    Science.gov (United States)

    Dotson, Jessie

    2015-01-01

    The Space Science and Astrobiology Division at NASA Ames Research Center consists of over 50 civil servants and more than 110 contractors, co-­-ops, post-­-docs and associates. Researchers in the division are pursuing investigations in a variety of fields including exoplanets, planetary science, astrobiology and astrophysics. In addition, division personnel support a wide variety of NASA missions including (but not limited to) Kepler, SOFIA, LADEE, JWST, and New Horizons. With such a wide variety of interesting research going on, distributed among three branches in at least 5 different buildings, it can be difficult to stay abreast of what one's fellow researchers are doing. Our goal in organizing this symposium is to facilitate communication and collaboration among the scientists within the division, and to give center management and other ARC researchers and engineers an opportunity to see what scientific research and science mission work is being done in the division. We are also continuing the tradition within the Space Science and Astrobiology Division to honor one senior and one early career scientist with the Pollack Lecture and the Early Career Lecture, respectively. With the Pollack Lecture, our intent is to select a senior researcher who has made significant contributions to any area of research within the space sciences, and we are pleased to honor Dr. William Borucki this year. With the Early Career Lecture, our intent is to select a young researcher within the division who, by their published scientific papers, shows great promise for the future in any area of space science research, and we are pleased to honor Dr. Melinda Kahre this year

  3. The Ame2012 atomic mass evaluation. Pt. 1. Evaluation of input data, adjustment procedures

    International Nuclear Information System (INIS)

    Audi, G; Wang, M.; Wapstra, A.H.; Kondev, F.G.; MacCormick, M.; Xu, X.; Pfeiffer, B.

    2012-01-01

    This paper is the first of two articles (Part I and Part II) that presents the results of the new atomic mass evaluation, Ame2012. It includes complete information on the experimental input data (including not used and rejected ones), as well as details on the evaluation procedures used to derive the tables with recommended values given in the second part. This article describes the evaluation philosophy and procedures that were implemented in the selection of specific nuclear reaction, decay and mass-spectrometer results. These input values were entered in the least-squares adjustment procedure for determining the best values for the atomic masses and their uncertainties. Calculation procedures and particularities of the AME are then described. All accepted and rejected data, including outweighed ones, are presented in a tabular format and compared with the adjusted values (obtained using the adjustment procedure). Differences with the previous Ame2003 evaluation are also discussed and specific information is presented for several cases that may be of interest to various AME users. The second Ame2012 article, the last one in this issue, gives a table with recommended values of atomic masses, as well as tables and graphs of derived quantities, along with the list of references used in both this Ame2012 evaluation and the Nubase2012 one (the first paper in this issue). (authors)

  4. Mitochondrial electron transport chain functions in long-lived Ames dwarf mice

    Science.gov (United States)

    Choksi, Kashyap B.; Nuss, Jonathan E.; DeFord, James H.; Papaconstantinou, John

    2011-01-01

    The age-associated decline in tissue function has been attributed to ROS-mediated oxidative damage due to mitochondrial dysfunction. The long-lived Ames dwarf mouse exhibits resistance to oxidative stress, a physiological characteristic of longevity. It is not known, however, whether there are differences in the electron transport chain (ETC) functions in Ames tissues that are associated with their longevity. In these studies we analyzed enzyme activities of ETC complexes, CI-CV and the coupled CI-CII and CII-CIII activities of mitochondria from several tissues of young, middle aged and old Ames dwarf mice and their corresponding wild type controls to identify potential mitochondrial prolongevity functions. Our studies indicate that post-mitotic heart and skeletal muscle from Ames and wild-type mice show similar changes in ETC complex activities with aging, with the exception of complex IV. Furthermore, the kidney, a slowly proliferating tissue, shows dramatic differences in ETC functions unique to the Ames mice. Our data show that there are tissue specific mitochondrial functions that are characteristic of certain tissues of the long-lived Ames mouse. We propose that this may be a factor in the determination of extended lifespan of dwarf mice. PMID:21934186

  5. Hepatic response to oxidative injury in long-lived Ames dwarf mice.

    Science.gov (United States)

    Sun, Liou Y; Bokov, Alex F; Richardson, Arlan; Miller, Richard A

    2011-01-01

    Multiple stress resistance pathways were evaluated in the liver of Ames dwarf mice before and after exposure to the oxidative toxin diquat, seeking clues to the exceptional longevity conferred by this mutation. Before diquat treatment, Ames dwarf mice, compared with nonmutant littermate controls, had 2- to 6-fold higher levels of expression of mRNAs for immediate early genes and 2- to 5-fold higher levels of mRNAs for genes dependent on the transcription factor Nrf2. Diquat led to a 2-fold increase in phosphorylation of the stress kinase ERK in control (but not Ames dwarf) mice and to a 50% increase in phosphorylation of the kinase JNK2 in Ames dwarf (but not control) mice. Diquat induction of Nrf2 protein was higher in dwarf mice than in controls. Of 6 Nrf2-responsive genes evaluated, 4 (HMOX, NQO-1, MT-1, and MT-2) remained 2- to 10-fold lower in control than in dwarf liver after diquat, and the other 2 (GCLM and TXNRD) reached levels already seen in dwarf liver at baseline. Thus, livers of Ames dwarf mice differ systematically from controls in multiple stress resistance pathways before and after exposure to diquat, suggesting mechanisms for stress resistance and extended longevity in Ames dwarf mice.

  6. Educational Projects in Unmanned Aerial Systems at the NASA Ames Research Center

    Science.gov (United States)

    Dahlgren, Robert P.

    2017-01-01

    Unmanned aerial systems (UAS), autonomy and robotics technology have been fertile ground for developing a wide variety of interdisciplinary student learning opportunities. In this talk, several projects will be described that leverage small fixed-wing UAS that have been modified to carry science payloads. These aircraft provide a unique hands-on experience for a wide range of students from college juniors to graduate students pursuing degrees in electrical engineering, aeronautical engineering, mechanical engineering, applied mathematics, physics, structural engineering and other majors. By combining rapid prototyping, design reuse and open-source philosophies, a sustainable educational program has been organized structured as full-time internships during the summer, part-time internships during the school year, short details for military cadets, and paid positions. As part of this program, every summer one or more UAS is developed from concept through design, build and test phases using the tools and facilities at the NASA Ames Research Center, ultimately obtaining statements of airworthiness and flight release from the Agency before test flights are performed. In 2016 and 2017 student projects focused on the theme of 3D printed modular airframes that may be optimized for a given mission and payload. Now in its fifth year this program has served over 35 students, and has provided a rich learning experience as they learn to rapidly develop new aircraft concepts in a highly regulated environment, on systems that will support principal investigators at university, NASA, and other US federal agencies.

  7. Mutagenicity of Tween 80-solvated mild gasification products in the Ames salmonella microsomal assay system

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-13

    The results of the Tween 80-solvated Ames testing of six mild gasification samples indicate significant mutagenic activity only in the composite materials (MG-119 and MG-120), previously suspected from the DMSO-solvated assays, which had shown some variable but ultimately insignificant mutagenic responses. The activity of these samples from the Tween 80-solvated assays was quite low when compared to either the positive controls or the SRC-II HD coal-liquefaction reference material. The class of mutagenic activity expressed by these samples solvated in Tween 80 was that of an indirect-acting, frameshift mutagen(s) since significant activity was found only on tester strain TA98 in the presence of the metabolic activation fraction (S9). Because DMSO and other solvents have been shown to affect the mutagenic activity of certain pure chemicals, the possibility of solvent/mutagen interactions in complex mixtures such as coal-derived liquids exists. Thus, the testing of the genotoxic activity of undefined, chemically complex compounds may require the use of at least two solvent systems to reduce the possibility of artifactual findings. 10 refs., 4 tabs.

  8. Ames-2016 line lists for 13 isotopologues of CO2: Updates, consistency, and remaining issues

    Science.gov (United States)

    Huang (黄新川), Xinchuan; Schwenke, David W.; Freedman, Richard S.; Lee, Timothy J.

    2017-12-01

    A new 626-based Ames-2 PES refinement and Ames-2016 line lists for 13 CO2 isotopologues are reported. A consistent σRMS = ±0.02 cm-1 is established for hundreds of isotopologue band origins using the Ames-2 PES. Ames-2016 line lists are computed at 296 K, 1000 K and 4000 K using the Ames-2 PES and the same DMS-N2 dipole surface used previously, with J up to 150, E‧ up to 24,000 cm-1 or 18,000 cm-1 and appropriate intensity cutoffs. The lists are compared to the CDSD-296, CDSD-4000 databases, UCL line lists, and a few recent highly accurate CO2 intensity measurements. Both agreements and discrepancies are discussed. Compared to the old Ames CO2 lists, the Ames-2016 line lists have line position deviations reduced by 50% or more, which consequently leads to more reliable intensities. The line shape parameters in the Ames-2016 line lists are predicted using the newly assigned conventional vibrational polyad quantum numbers for rovibrational levels below 12,000 cm-1 so the quality of the line shape parameters is similar to that of CDSD or HITRAN. This study further proves that a semi-empirically refined PES (Ames-1 and Ames-2) coupled with a high quality ab initio DMS (DMS-N2 and UCL) may generate IR predictions with consistent accuracy and is thus helpful in the analysis of laboratory spectra and simulations of various isotopologues. The Ames-2016 lists based on DMS-N2 have reached the ∼1% intensity prediction accuracy level for the recent 626 30013-00001 and 20013-00001 bands, but further quantification and improvements require sub-percent or sub-half-percent accurate experimental intensities. The inter-isotopologue consistency of the intensity prediction accuracies should have reached better than 1-3% for regular bands not affected by resonances. Since the Effective Dipole Models (EDM) in CDSD and HITRAN have 1-20% or even larger uncertainties, we show that the Ames lists can provide better alternative IR data for many hard-to-determine isotopologue bands

  9. Wind-tunnel investigation of the thrust augmentor performance of a large-scale swept wing model. [in the Ames 40 by 80 foot wind tunnel

    Science.gov (United States)

    Koenig, D. G.; Falarski, M. D.

    1979-01-01

    Tests were made in the Ames 40- by 80-foot wind tunnel to determine the forward speed effects on wing-mounted thrust augmentors. The large-scale model was powered by the compressor output of J-85 driven viper compressors. The flap settings used were 15 deg and 30 deg with 0 deg, 15 deg, and 30 deg aileron settings. The maximum duct pressure, and wind tunnel dynamic pressure were 66 cmHg (26 in Hg) and 1190 N/sq m (25 lb/sq ft), respectively. All tests were made at zero sideslip. Test results are presented without analysis.

  10. The Ame2012 atomic mass evaluation. Pt. 2. Tables, graphs and references

    International Nuclear Information System (INIS)

    Wang, M.; Audi, G.; Wapstra, A.H.; Kondev, F.G.; MacCormick, M.; Xu, X.; Pfeiffer, B.

    2012-01-01

    This paper is the second part of the new evaluation of atomic masses, Ame2012. From the results of a least-squares calculation, described in Part I, for all accepted experimental data, we derive here tables and graphs to replace those of Ame2003. The first table lists atomic masses. It is followed by a table of the influences of data on primary nuclides, a table of separation energies and reaction energies, and finally, a series of graphs of separation and decay energies. The last section in this paper lists all references to the input data used in Part I of this Ame2012 and also to the data included in the Nubase2012 evaluation (first paper in this issue). (authors)

  11. Prophage induction, mutagenesis, and cell survival of Ames' mutagen tester strains after 8-methoxypsoralen plus ultraviolet light-A

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, L.A.; DeMeo, M. (California Univ., Los Angeles (USA)); Lowe, N. (Combined UCLA-WADSWORTH Dermatology Program, Los Angeles, CA (USA))

    1983-10-01

    8-methoxypsoralen (8-MOP) is not detected as a mutagen in the standard Ames test either in the presence or absence of S9-mix and/or ultraviolet light-A (320-400 nm). The Ames strains have been shown to harbor bacteriophages that are inducible by carcinogens and mutagens. Psoralen plus UVA (PUVA) was found to be a potent prophage inducing treatment. Induction was observed in TA1535, TA1538, TA98, TA100, TA1978 and TA1975 with 8-MOP and UVA. PUVA is a potent bactericidal treatment at concentrations of 8-MOP above 0.5 ..mu..g/ml and 2.5 kJ/m/sup 2/ in tester strains TA1535, TA1538, TA98 and TA100. PUVA is known to be bactericidal, but the cytotoxicity observed in the present study was unique in that the frameshift tester strains (TA1538 and TA98) were more sensitive to the lethal effects of PUVA than the base pair tester strains (TA1535 and TA100). The differential cytotoxicity in such closely related strains led to the examination of some of the strains from which the Ames strains were derived. It is postulated that TA1535 retains a DNA repair function that is lost by TA1538 during the selection for uvrB deficient strains.

  12. Corrective Action Plan in response to the March 1992 Tiger Team Assessment of the Ames Laboratory

    International Nuclear Information System (INIS)

    1992-01-01

    On March 5, 1992, a Department of Energy (DOE) Tiger Team completed an assessment of the Ames Laboratory, located in Ames, Iowa. The purpose of the assessment was to provide the Secretary of Energy with a report on the status and performance of Environment, Safety and Health (ES ampersand H) programs at Ames Laboratory. Detailed findings of the assessment are presented in the report, DOE/EH-0237, Tiger Team Assessment of the Ames Laboratory. This document, the Ames Laboratory Corrective Action Plan (ALCAP), presents corrective actions to overcome deficiencies cited in the Tiger Team Assessment. The Tiger Team identified 53 Environmental findings, from which the Team derived four key findings. In the Safety and Health (S ampersand H) area, 126 concerns were identified, eight of which were designated Category 11 (there were no Category I concerns). Seven key concerns were derived from the 126 concerns. The Management Subteam developed 19 findings which have been summarized in four key findings. The eight S ampersand H Category 11 concerns identified in the Tiger Team Assessment were given prompt management attention. Actions to address these deficiencies have been described in individual corrective action plans, which were submitted to DOE Headquarters on March 20, 1992. The ALCAP includes actions described in this early response, as well as a long term strategy and framework for correcting all remaining deficiencies. Accordingly, the ALCAP presents the organizational structure, management systems, and specific responses that are being developed to implement corrective actions and to resolve root causes identified in the Tiger Team Assessment. The Chicago Field Office (CH), IowaState University (ISU), the Institute for Physical Research and Technology (IPRT), and Ames Laboratory prepared the ALCAP with input from the DOE Headquarters, Office of Energy Research (ER)

  13. A Survey of Knowledge Management Research & Development at NASA Ames Research Center

    Science.gov (United States)

    Keller, Richard M.; Clancy, Daniel (Technical Monitor)

    2002-01-01

    This chapter catalogs knowledge management research and development activities at NASA Ames Research Center as of April 2002. A general categorization scheme for knowledge management systems is first introduced. This categorization scheme divides knowledge management capabilities into five broad categories: knowledge capture, knowledge preservation, knowledge augmentation, knowledge dissemination, and knowledge infrastructure. Each of nearly 30 knowledge management systems developed at Ames is then classified according to this system. Finally, a capsule description of each system is presented along with information on deployment status, funding sources, contact information, and both published and internet-based references.

  14. Adjoint Method and Predictive Control for 1-D Flow in NASA Ames 11-Foot Transonic Wind Tunnel

    Science.gov (United States)

    Nguyen, Nhan; Ardema, Mark

    2006-01-01

    This paper describes a modeling method and a new optimal control approach to investigate a Mach number control problem for the NASA Ames 11-Foot Transonic Wind Tunnel. The flow in the wind tunnel is modeled by the 1-D unsteady Euler equations whose boundary conditions prescribe a controlling action by a compressor. The boundary control inputs to the compressor are in turn controlled by a drive motor system and an inlet guide vane system whose dynamics are modeled by ordinary differential equations. The resulting Euler equations are thus coupled to the ordinary differential equations via the boundary conditions. Optimality conditions are established by an adjoint method and are used to develop a model predictive linear-quadratic optimal control for regulating the Mach number due to a test model disturbance during a continuous pitch

  15. Mixing alcohol with energy drink (AMED) and total alcohol consumption : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Verster, Joris C|info:eu-repo/dai/nl/241442702; Benson, Sarah; Johnson, Sean J; Scholey, Andrew; Alford, Chris

    It has been suggested that consuming alcohol mixed with energy drink (AMED) may increase total alcohol consumption. Aims of this systematic review and meta-analysis were (i) to compare alcohol consumption of AMED consumers with alcohol only (AO) consumers (between-group comparisons), and (ii) to

  16. Ames collaborative study of cosmic-ray neutrons. II. Low- and mid-latitude flights

    International Nuclear Information System (INIS)

    Stephens, L.D.; McCaslin, J.B.; Smith, A.R.; Thomas, R.H.; Hewitt, J.E.; Hughes, L.

    1978-01-01

    The continuing progress of the Ames Collaborative Study of Cosmic Ray Neutrons is described. Data obtained aboard flights from Hawaii at altitudes of 41,000 and 45,000 feet, and in the range of geomagnetic latitude 17 0 N less than or equal to lambda less than or equal to 21 0 N are reported. Preliminary estimates of neutron spectra were made

  17. Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen.

    Science.gov (United States)

    Capitano, Maegan L; Chitteti, Brahmananda R; Cooper, Scott; Srour, Edward F; Bartke, Andrzej; Broxmeyer, Hal E

    2015-06-01

    Ames hypopituitary dwarf mice are deficient in growth hormone, thyroid-stimulating hormone, and prolactin. The phenotype of these mice demonstrates irregularities in the immune system with skewing of the normal cytokine milieu towards a more anti-inflammatory environment. However, the hematopoietic stem and progenitor cell composition of the bone marrow (BM) and spleen in Ames dwarf mice has not been well characterized. We found that there was a significant decrease in overall cell count when comparing the BM and spleen of 4-5 month old dwarf mice to their littermate controls. Upon adjusting counts to differences in body weight between the dwarf and control mice, the number of granulocyte-macrophage progenitors, confirmed by immunophenotyping and colony-formation assay was increased in the BM. In contrast, the numbers of all myeloid progenitor populations in the spleen were greatly reduced, as confirmed by colony-formation assays. This suggests that there is a shift of myelopoiesis from the spleen to the BM of Ames dwarf mice; however, this shift does not appear to involve erythropoiesis. The reasons for this unusual shift in spleen to marrow hematopoiesis in Ames dwarf mice are yet to be determined but may relate to the decreased hormone levels in these mice. Copyright © 2015. Published by Elsevier Inc.

  18. The AME2003 atomic mass evaluation (I). Evaluation of input data, adjustment procedures

    International Nuclear Information System (INIS)

    Wapstra, A.H.; Audi, G.; Thibault, C.

    2003-01-01

    This paper is the first of two parts presenting the result of a new evaluation of atomic masses (AME2003). In this first part we give full information on the used and rejected input data and on the procedures used in deriving the tables in the second part. We first describe the philosophy and procedures used in selecting nuclear-reaction, decay, and mass spectrometric results as input values in a least-squares evaluation of best values for atomic masses. The calculation procedures and particularities of the AME are then described. All accepted data, and rejected ones with a reported precision still of interest, are presented in a table and compared there with the adjusted values. The differences with the earlier evaluation are briefly discussed and information is given of interest for the users of this AME. The second paper for the AME2003, last in this issue, gives a table of atomic masses, tables and graphs of derived quantities, and the list of references used in both this evaluation and the NUBASE2003 table (first paper in this issue). AMDC: http://csnwww.in2p3.fr/AMDC/

  19. The NASA Ames Polycyclic Aromatic Hydrocarbon Infrared Spectroscopic Database : The Computed Spectra

    NARCIS (Netherlands)

    Bauschlicher, C. W.; Boersma, C.; Ricca, A.; Mattioda, A. L.; Cami, J.; Peeters, E.; de Armas, F. Sanchez; Saborido, G. Puerta; Hudgins, D. M.; Allamandola, L. J.

    The astronomical emission features, formerly known as the unidentified infrared bands, are now commonly ascribed to polycyclic aromatic hydrocarbons (PAHs). The laboratory experiments and computational modeling done at the NASA Ames Research Center to create a collection of PAH IR spectra relevant

  20. Exploration of a steamship wreck off Amee shoals, Goa, India: A preliminary report

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Gaur, A; Sundaresh

    Recent explorations off Amee shoals, Goa, have brought to light the remains of a steel-hulled steam-engine shipwreck, scattered over a large area. Though sparse and heavily salvaged, this site represents the first discovery of a steamship wreck...

  1. LYRA and other projects on RPV steel embrittlement study and mitigation of the AMES network

    International Nuclear Information System (INIS)

    Debarberis, L.; Estorff, U. von; Crutzen, S.; Beers, M.; Stamm, H.; Vries, M.I. de; Tjoa, G.L.

    1998-01-01

    Within the framework of the European Network AMES, Ageing Materials evaluation and Studies, a number of experimental works on RPV materials embrittlement are carried out at the Institute of Advanced Materials (AIM) of the Joint Research Centre (JRC) of the European Commission (EC). The objectives of AMES are mainly the understanding of the property degradation phenomena of RPV western reference steels like JRQ and HSST, eastern RPV steels like 15X2mFA and 15H2X15, and annealing possibilities. In order to conduct a very high quality irradiation rig, LYRA facility, has been designed and developed at the High Flux Reactor (HFR) Petten. An other dedicated rig, named LIMA, has been developed at the HFR Petten in order to irradiate RPV steels, internals and in-core materials under typical BWR/PWR conditions. The samples can be irradiated in pressurised water up to 160 bar, 320 deg. C, and the water chemistry fully controlled. For irradiation of standard or miniaturised LWR related materials samples, another group of well experienced irradiation devices with inert gas or liquid metals environment are employed. These devices are tailored to their various specific applications. This paper is intended to give information about the structure and the objectives of the existing European network AMES, and to present the various AMES main and spin-off projects, including a brief description on he modelling activities related to RPV materials embrittlement. (author)

  2. Cultivating a Grassroots Aerospace Innovation Culture at NASA Ames Research Center

    Science.gov (United States)

    D'Souza, Sarah; Sanchez, Hugo; Lewis, Ryan

    2017-01-01

    This paper details the adaptation of specific 'knowledge production' methods to implement a first of its kind, grassroots event that provokes a cultural change in how the NASA Ames civil servant community engages in the creation and selection of innovative ideas. Historically, selection of innovative proposals at NASA Ames Research Center is done at the highest levels of management, isolating the views and perspectives of the larger civil servant community. Additionally, NASA innovation programs are typically open to technical organizations and do not engage non-technical organizations to bring forward innovative processes/business practices. Finally, collaboration on innovative ideas and associated solutions tend to be isolated to organizational silos. In this environment, not all Ames employees feel empowered to innovate and opportunities for employee collaboration are limited. In order to address these issues, the 'innovation contest' method was adapted to create the NASA Ames Innovation Fair, a unique, grassroots innovation opportunity for the civil servant community. The Innovation Fair consisted of a physical event with a virtual component. The physical event provided innovators the opportunity to collaborate and pitch their innovations to the NASA Ames community. The civil servant community then voted for the projects that they viewed as innovative and would contribute to NASA's core mission, making this event a truly grassroots effort. The Innovation Fair website provided a location for additional knowledge sharing, discussion, and voting. On March 3rd, 2016, the 'First Annual NASA Ames Innovation Fair' was held with 49 innovators and more than 300 participants collaborating and/or voting for the best innovations. Based on the voting results, seven projects were awarded seed funding for projects ranging from innovative cost models to innovations in aerospace technology. Surveys of both innovators and Fair participants show the Innovation Fair was successful

  3. Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice.

    Science.gov (United States)

    Brown-Borg, Holly M; Johnson, W Thomas; Rakoczy, Sharlene G

    2012-02-01

    Reduced signaling of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) pathway is associated with extended life span in several species. Ames dwarf mice are GH-deficient and live >50% longer than wild-type littermates. Previously, we have shown that tissues from Ames mice exhibit elevated levels of antioxidative enzymes, less H(2)O(2) production, and lower oxidative damage suggesting that mitochondrial function may differ between genotypes. To explore the relationship between hormone deficiency and mitochondria in mice with extended longevity, we evaluated activity, protein, and gene expression of oxidative phosphorylation components in dwarf and wild-type mice at varying ages. Liver complex I + III activity was higher in dwarf mice compared to wild-type mice. The activity of I + III decreased between 3 and 20 months of age in both genotypes with greater declines in wild-type mice in liver and skeletal muscle. Complex IV activities in the kidney were elevated in 3- and 20-month-old dwarf mice relative to wild-type mice. In Ames mice, protein levels of the 39 kDa complex I subunit were elevated at 20 months of age when compared to wild-type mouse mitochondria for every tissue examined. Kidney and liver mitochondria from 20-month-old dwarf mice had elevated levels of both mitochondrially-encoded and nuclear-encoded complex IV proteins compared to wild-type mice (p dwarf mice. Overall, we found that several components of the oxidative phosphorylation (OXPHOS) system were elevated in Ames mice. Mitochondrial to nuclear DNA ratios were not different between genotypes despite the marked increase in PGC-1α levels in dwarf mice. The increased OXPHOS activities, along with lower ROS production in dwarf mice, predict enhanced mitochondrial function and efficiency, two factors likely contributing to long-life in Ames mice.

  4. Performance of the OVERFLOW-MLP and LAURA-MLP CFD Codes on the NASA Ames 512 CPU Origin System

    Science.gov (United States)

    Taft, James R.

    2000-01-01

    The shared memory Multi-Level Parallelism (MLP) technique, developed last year at NASA Ames has been very successful in dramatically improving the performance of important NASA CFD codes. This new and very simple parallel programming technique was first inserted into the OVERFLOW production CFD code in FY 1998. The OVERFLOW-MLP code's parallel performance scaled linearly to 256 CPUs on the NASA Ames 256 CPU Origin 2000 system (steger). Overall performance exceeded 20.1 GFLOP/s, or about 4.5x the performance of a dedicated 16 CPU C90 system. All of this was achieved without any major modification to the original vector based code. The OVERFLOW-MLP code is now in production on the inhouse Origin systems as well as being used offsite at commercial aerospace companies. Partially as a result of this work, NASA Ames has purchased a new 512 CPU Origin 2000 system to further test the limits of parallel performance for NASA codes of interest. This paper presents the performance obtained from the latest optimization efforts on this machine for the LAURA-MLP and OVERFLOW-MLP codes. The Langley Aerothermodynamics Upwind Relaxation Algorithm (LAURA) code is a key simulation tool in the development of the next generation shuttle, interplanetary reentry vehicles, and nearly all "X" plane development. This code sustains about 4-5 GFLOP/s on a dedicated 16 CPU C90. At this rate, expected workloads would require over 100 C90 CPU years of computing over the next few calendar years. It is not feasible to expect that this would be affordable or available to the user community. Dramatic performance gains on cheaper systems are needed. This code is expected to be perhaps the largest consumer of NASA Ames compute cycles per run in the coming year.The OVERFLOW CFD code is extensively used in the government and commercial aerospace communities to evaluate new aircraft designs. It is one of the largest consumers of NASA supercomputing cycles and large simulations of highly resolved full

  5. M2-F1 mounted in NASA Ames Research Center 40x80 foot wind tunnel

    Science.gov (United States)

    1962-01-01

    After the first attempted ground-tow tests of the M2-F1 in March 1963, the vehicle was taken to the Ames Research Center, Mountain View, CA, for wind-tunnel testing. During these tests, Milt Thompson and others were in the M2-F1 to position the control surfaces for each test. The wingless, lifting body aircraft design was initially conceived as a means of landing an aircraft horizontally after atmospheric reentry. The absence of wings would make the extreme heat of re-entry less damaging to the vehicle. In 1962, Dryden management approved a program to build a lightweight, unpowered lifting body as a prototype to flight test the wingless concept. It would look like a 'flying bathtub,' and was designated the M2-F1, the 'M' referring to 'manned' and 'F' referring to 'flight' version. It featured a plywood shell placed over a tubular steel frame crafted at Dryden. Construction was completed in 1963. The first flight tests of the M2-F1 were over Rogers Dry Lake at the end of a tow rope attached to a hopped-up Pontiac convertible driven at speeds up to about 120 mph. This vehicle needed to be able to tow the M2-F1 on the Rogers Dry Lakebed adjacent to NASA's Flight Research Center (FRC) at a minimum speed of 100 miles per hour. To do that, it had to handle the 400-pound pull of the M2-F1. Walter 'Whitey' Whiteside, who was a retired Air Force maintenance officer working in the FRC's Flight Operations Division, was a dirt-bike rider and hot-rodder. Together with Boyden 'Bud' Bearce in the Procurement and Supply Branch of the FRC, Whitey acquired a Pontiac Catalina convertible with the largest engine available. He took the car to Bill Straup's renowned hot-rod shop near Long Beach for modification. With a special gearbox and racing slicks, the Pontiac could tow the 1,000-pound M2-F1 110 miles per hour in 30 seconds. It proved adequate for the roughly 400 car tows that got the M2-F1 airborne to prove it could fly safely and to train pilots before they were towed behind a C

  6. Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.

    Science.gov (United States)

    Csiszar, Anna; Labinskyy, Nazar; Perez, Viviana; Recchia, Fabio A; Podlutsky, Andrej; Mukhopadhyay, Partha; Losonczy, Gyorgy; Pacher, Pal; Austad, Steven N; Bartke, Andrzej; Ungvari, Zoltan

    2008-11-01

    Hypopituitary Ames dwarf mice have low circulating growth hormone (GH)/IGF-I levels, and they have extended longevity and exhibit many symptoms of delayed aging. To elucidate the vascular consequences of Ames dwarfism we compared endothelial O2(-) and H2O2 production, mitochondrial reactive oxygen species (ROS) generation, expression of antioxidant enzymes, and nitric oxide (NO) production in aortas of Ames dwarf and wild-type control mice. In Ames dwarf aortas endothelial O2(-) and H2O2 production and ROS generation by mitochondria were enhanced compared with those in vessels of wild-type mice. In Ames dwarf aortas there was a less abundant expression of Mn-SOD, Cu,Zn-SOD, glutathione peroxidase (GPx)-1, and endothelial nitric oxide synthase (eNOS). NO production and acetylcholine-induced relaxation were also decreased in aortas of Ames dwarf mice. In cultured wild-type mouse aortas and in human coronary arterial endothelial cells treatment with GH and IGF significantly reduced cellular O2(-) and H2O2 production and ROS generation by mitochondria and upregulated expression of Mn-SOD, Cu,Zn-SOD, GPx-1, and eNOS. Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress.

  7. A non-randomized [corrected] controlled trial of the active music engagement (AME) intervention on children with cancer.

    Science.gov (United States)

    Robb, Sheri L; Clair, Alicia A; Watanabe, Masayo; Monahan, Patrick O; Azzouz, Faouzi; Stouffer, Janice W; Ebberts, Allison; Darsie, Emily; Whitmer, Courtney; Walker, Joey; Nelson, Kirsten; Hanson-Abromeit, Deanna; Lane, Deforia; Hannan, Ann

    2008-07-01

    Coping theorists argue that environmental factors affect how children perceive and respond to stressful events such as cancer. However, few studies have investigated how particular interventions can change coping behaviors. The active music engagement (AME) intervention was designed to counter stressful qualities of the in-patient hospital environment by introducing three forms of environmental support. The purpose of this multi-site randomized controlled trial was to determine the efficacy of the AME intervention on three coping-related behaviors (i.e. positive facial affect, active engagement, and initiation). Eighty-three participants, ages 4-7, were randomly assigned to one of three conditions: AME (n = 27), music listening (ML; n = 28), or audio storybooks (ASB; n = 28). Conditions were videotaped to facilitate behavioral data collection using time-sampling procedures. After adjusting for baseline differences, repeated measure analyses indicated that AME participants had a significantly higher frequency of coping-related behaviors compared with ML or ASB. Positive facial affect and active engagement were significantly higher during AME compared with ML and ASB (p<0.0001). Initiation was significantly higher during AME than ASB (p<0.05). This study supports the use of the AME intervention to encourage coping-related behaviors in hospitalized children aged 4-7 receiving cancer treatment. (c) 2007 John Wiley & Sons, Ltd.

  8. Aerial radiological survey of US Department of Energy sites in Ames, Iowa. Date of survey: May 1977

    International Nuclear Information System (INIS)

    1979-07-01

    An aerial radiological survey to measure terrestrial gamma radiation was carried out over five areas totaling 10 km 2 within the town of Ames, Iowa. Gamma ray data were measured over Ames Laboratory, several sections of downtown Ames, and the surrounding area. This was accomplished by flying parallel east-west lines 61 m apart. Processed data indicated that three areas showed increased activity levels of at least twice average background: the reactor, the waste treatment area, and a small area near the airport runway

  9. Comparison of acoustic data from a 102 mm conic nozzle as measured in the RAE 24-foot wind tunnel and the NASA Ames 40- by 80-foot wind tunnel

    Science.gov (United States)

    Atencio, A., Jr.; Mckie, J.

    1982-01-01

    A cooperative program between the Royal Aircraft Establishment (RAE), England, and the NASA Ames Research Center was initiated to compare acoustic measurements made in the RAE 24-foot wind tunnel and in the Ames 40- by 80-foot wind tunnel. The acoustic measurements were made in both facilities using the same 102 mm conical nozzle supplied by the RAE. The nozzle was tested by each organization using its respective jet test rig. The mounting hardware and nozzle exit conditions were matched as closely as possible. The data from each wind tunnel were independently analyzed by the respective organization. The results from these tests show good agreement. In both facilities, interference with acoustic measurement is evident at angles in the forward quadrant.

  10. The AMES Laboratory chemical disposal site removal action: Source removal, processing, and disposal

    International Nuclear Information System (INIS)

    Shirley, R.S.

    1996-01-01

    The Ames Laboratory has historically supported the U.S. Department of Energy (USDOE) and its predecessor agencies by providing research into the purification and manufacturing of high purity uranium, thorium, and yttrium metals. Much of this work was accomplished in the late 1950s and early 1960s prior to the legislation of strict rules and regulations covering the disposal of radioactive and chemical wastes. As a result, approximately 800 cubic meters of low-level radioactive wastes, chemical wastes, and contaminated debris were disposed in nine near surface cells located in a 0.75 hectare plot of land owned by Iowa State University in Ames, Iowa. Under a national contract with the U.S. Army Corps of Engineers (USACE), OHM Remediation Services Corp (OHM) was tasked with providing turnkey environmental services to remove, process, package, transport, and coordinate the disposal of the waste materials and contaminated environmental media

  11. Long-lived ames dwarf mice are resistant to chemical stressors.

    Science.gov (United States)

    Bokov, Alex F; Lindsey, Merry L; Khodr, Christina; Sabia, Marian R; Richardson, Arlan

    2009-08-01

    To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with paraquat, diquat, and dobutamine. In young adult animals, 95% of male and 39% of female controls died after paraquat administration, but no dwarf animals died. When the experiment was repeated at an older age or a higher dosage of paraquat, dwarf mice still showed greater resistance. Dwarf mice also were more resistant to diquat; 80% of male and 60% of female controls died compared with 40% and 20% of dwarf mice, despite greater sensitivity of dwarf liver to diquat. Dwarf mice were also less sensitive to dobutamine-induced cardiac stress and had lower levels of liver and lung F(2)-isoprostanes. This is the first direct in vivo evidence that long-lived Ames dwarf mice have enhanced resistance to chemical insult, particularly oxidative stressors.

  12. Antimutagenic components in Glycyrrhiza against N-methyl-N-nitrosourea in the Ames assay.

    Science.gov (United States)

    Inami, Keiko; Mine, Yusuke; Kojo, Yukiko; Tanaka, Satomi; Ishikawa, Satoko; Mochizuki, Masataka

    2017-03-01

    Antimutagenesis against N-nitroso compounds contribute to prevention of human cancer. We have found that Glycyrrhiza aspera ethanolic extract exhibits antimutagenic activity against N-methyl-N-nitrosourea (MNU) using the Ames assay with Salmonella typhimurium TA1535. In the present study, eight purified components from Glycyrrhiza, namely glabridin, glycyrrhetinic acid, glycyrrhizin, licochalcone A, licoricesaponin H2, licoricesaponin G2, liquiritigenin and liquiritin were evaluated for their antimutagenicity against MNU in the Ames assay with S. typhimurium TA1535. Glycyrrhetinic acid, glycyrrhizin, licoricesaponin G2, licoricesaponin H2 and liquiritin did not show the antimutagenicity against MNU in S. typhimurium TA1535. Glabridin, licochalcone A and liquiritigenin reduced revertant colonies derived from MNU in S. typhimurium TA1535 without showing cytotoxic effects, indicating that these compounds possess antimutagenic activity against MNU. The inhibitory activity of glabridin and licochalcone A was more effective than that of liquiritigenin. Thus, Glycyrrhiza contains antimutagenic components against DNA alkylating, direct-acting carcinogens.

  13. The Ames Laboratory Chemical Disposal Site removal action: Source removal, processing, and disposal

    International Nuclear Information System (INIS)

    Shirley, R.S.

    1995-01-01

    The Ames Laboratory has historically supported the US Department of Energy (USDOE) and its predecessor agencies by providing research into the purification and manufacturing of high purity uranium, thorium, and yttrium metals. Much of this work was accomplished in the late 1950s and early 1960s prior to the legislation of strict rules and regulations covering the disposal of radioactive and chemical wastes. As a result, approximately 800 cubic meters of low-level radioactive wastes, mixed wastes, and contaminated debris were disposed in nine near surface cells located in a 0.75 hectare plot of land owned by Iowa State University in Ames, Iowa. Under a national contract with the US Army Corps of Engineers (USACE), OHM Remediation Services Corp. (OHM) was tasked with providing turnkey environmental services to remove, process, package, transport, and coordinate the disposal of the waste materials and contaminated environmental media

  14. Shock Tube and Ballistic Range Facilities at NASA Ames Research Center

    Science.gov (United States)

    Grinstead, Jay H.; Wilder, Michael C.; Reda, Daniel C.; Cornelison, Charles J.; Cruden, Brett A.; Bogdanoff, David W.

    2010-01-01

    The Electric Arc Shock Tube (EAST) facility and the Hypervelocity Free Flight Aerodynamic Facility (HFFAF) at NASA Ames Research Center are described. These facilities have been in operation since the 1960s and have supported many NASA missions and technology development initiatives. The facilities have world-unique capabilities that enable experimental studies of real-gas aerothermal, gas dynamic, and kinetic phenomena of atmospheric entry.

  15. Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002

    OpenAIRE

    Zhang, Zhongheng; Hong, Yucai; Smischney, Nathan J.; Kuo, Han-Pin; Tsirigotis, Panagiotis; Rello, Jordi; Kuan, Win Sen; Jung, Christian; Robba, Chiara; Taccone, Fabio Silvio; Leone, Marc; Spapen, Herbert; Grimaldi, David; Van Poucke, Sven; Simpson, Steven Q.

    2017-01-01

    Severe sepsis and septic shock are major causes of morbidity and mortality in patients entering the emergency department (ED) or intensive care unit (ICU). Despite substantial efforts to improve patient outcome, treatment of sepsis remains challenging to clinicians. In this context, early goal directed therapy (EGDT) represents an important concept emphasizing both early recognition of sepsis and prompt initiation of a structured treatment algorithm. As part of the AME evidence series on seps...

  16. Simulation of Shuttle launch G forces and acoustic loads using the NASA Ames Research Center 20G centrifuge

    Science.gov (United States)

    Shaw, T. L.; Corliss, J. M.; Gundo, D. P.; Mulenburg, G. M.; Breit, G. A.; Griffith, J. B.

    1994-01-01

    The high cost and long times required to develop research packages for space flight can often be offset by using ground test techniques. This paper describes a space shuttle launch and reentry simulating using the NASA Ames Research Center's 20G centrifuge facility. The combined G-forces and acoustic environment during shuttle launch and landing were simulated to evaluate the effect on a payload of laboratory rates. The launch G force and acoustic profiles are matched to actual shuttle launch data to produce the required G-forces and acoustic spectrum in the centrifuge test cab where the rats were caged on a free-swinging platform. For reentry, only G force is simulated as the aero-acoustic noise is insignificant compared to that during launch. The shuttle G-force profiles of launch and landing are achieved by programming the centrifuge drive computer to continuously adjust centrifuge rotational speed to obtain the correct launch and landing G forces. The shuttle launch acoustic environment is simulated using a high-power, low-frequency audio system. Accelerometer data from STS-56 and microphone data from STS-1 through STS-5 are used as baselines for the simulations. This paper provides a description of the test setup and the results of the simulation with recommendations for follow-on simulations.

  17. NASA Ames DEVELOP Interns: Helping the Western United States Manage Natural Resources One Project at a Time

    Science.gov (United States)

    Justice, Erin; Newcomer, Michelle

    2010-01-01

    The western half of the United States is made up of a number of diverse ecosystems ranging from arid desert to coastal wetlands and rugged forests. Every summer for the past 7 years students ranging from high school to graduate level gather at NASA Ames Research Center (ARC) as part of the DEVELOP Internship Program. Under the guidance of Jay Skiles [Ames Research Center (ARC) - Ames DEVELOP Manager] and Cindy Schmidt [ARC/San Jose State University Ames DEVELOP Coordinator] they work as a team on projects exploring topics including: invasive species, carbon flux, wetland restoration, air quality monitoring, storm visualizations, and forest fires. The study areas for these projects have been in Washington, Utah, Oregon, Nevada, Hawaii, Alaska and California. Interns combine data from NASA and partner satellites with models and in situ measurements to complete prototype projects demonstrating how NASA data and resources can help communities tackle their Earth Science related problems.

  18. State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet

    Science.gov (United States)

    State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet (Presented by Dr. Marilyn J. Aardema, Chief Scientific Advisor, Toxicology, Dr. Leon Stankowski, et. al. (6/28/2012)

  19. Quantitative assessment of the dose-response of alkylating agents in DNA repair proficient and deficient ames tester strains.

    Science.gov (United States)

    Tang, Leilei; Guérard, Melanie; Zeller, Andreas

    2014-01-01

    Mutagenic and clastogenic effects of some DNA damaging agents such as methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) have been demonstrated to exhibit a nonlinear or even "thresholded" dose-response in vitro and in vivo. DNA repair seems to be mainly responsible for these thresholds. To this end, we assessed several mutagenic alkylators in the Ames test with four different strains of Salmonella typhimurium: the alkyl transferases proficient strain TA1535 (Ogt+/Ada+), as well as the alkyl transferases deficient strains YG7100 (Ogt+/Ada-), YG7104 (Ogt-/Ada+) and YG7108 (Ogt-/Ada-). The known genotoxins EMS, MMS, temozolomide (TMZ), ethylnitrosourea (ENU) and methylnitrosourea (MNU) were tested in as many as 22 concentration levels. Dose-response curves were statistically fitted by the PROAST benchmark dose model and the Lutz-Lutz "hockeystick" model. These dose-response curves suggest efficient DNA-repair for lesions inflicted by all agents in strain TA1535. In the absence of Ogt, Ada is predominantly repairing methylations but not ethylations. It is concluded that the capacity of alkyl-transferases to successfully repair DNA lesions up to certain dose levels contributes to genotoxicity thresholds. Copyright © 2013 Wiley Periodicals, Inc.

  20. Building bridges between theory and practice in medical education using a design-based research approach: AMEE Guide No. 60.

    Science.gov (United States)

    Dolmans, Diana H J M; Tigelaar, D

    2012-01-01

    Medical education research has grown enormously over the past 20 years, but it does not sufficiently make use of theories, according to influential leaders and researchers in this field. In this AMEE Guide, it is argued that design-based research (DBR) studies should be conducted much more in medical education design research because these studies both advance the testing and refinement of theories and advance educational practice. In this Guide, the essential characteristics of DBR as well as how DBR differs from other approach such as formative evaluation are explained. It is also explained what the pitfalls and challenges of DBR are. The main challenges deal with how to insure that DBR studies reveal findings that are of a broader relevance than the local situation and how to insure that DBR contributes toward theory testing and refinement. An example of a series of DBR studies on the design of a teaching portfolio in higher education that is aimed at stimulating a teacher's professional development is described, to illustrate how DBR studies actually work in practice. Finally, it is argued that DBR-studies could play an important role in the advancement of theory and practice in the two broad domains of designing or redesigning work-based learning environments and assessment programs.

  1. Ames S-32 O-16 O-18 Line List for High-Resolution Experimental IR Analysis

    Science.gov (United States)

    Huang, Xinchuan; Schwenke, David W.; Lee, Timothy J.

    2016-01-01

    By comparing to the most recent experimental data and spectra of the SO2 628 ?1/?3 bands (see Ulenikov et al., JQSRT 168 (2016) 29-39), this study illustrates the reliability and accuracy of the Ames-296K SO2 line list, which is accurate enough to facilitate such high-resolution spectroscopic analysis. The SO2 628 IR line list is computed on a recently improved potential energy surface (PES) refinement, denoted Ames-Pre2, and the published purely ab initio CCSD(T)/aug-cc-pVQZ dipole moment surface. Progress has been made in both energy level convergence and rovibrational quantum number assignments agreeing with laboratory analysis models. The accuracy of the computed 628 energy levels and line list is similar to what has been achieved and reported for SO2 626 and 646, i.e. 0.01-0.03 cm(exp -1) for bands up to 5500 cm(exp -1). During the comparison, we found some discrepancies in addition to overall good agreements. The three-IR-list based feature-by-feature analysis in a 0.25 cm(exp -1) spectral window clearly demonstrates the power of the current Ames line lists with new assignments, correction of some errors, and intensity contributions from varied sources including other isotopologues. We are inclined to attribute part of detected discrepancies to an incomplete experimental analysis and missing intensity in the model. With complete line position, intensity, and rovibrational quantum numbers determined at 296 K, spectroscopic analysis is significantly facilitated especially for a spectral range exhibiting such an unusually high density of lines. The computed 628 rovibrational levels and line list are accurate enough to provide alternatives for the missing bands or suspicious assignments, as well as helpful to identify these isotopologues in various celestial environments. The next step will be to revisit the SO2 828 and 646 spectral analyses.

  2. Feature combination networks for the interpretation of statistical machine learning models: application to Ames mutagenicity.

    Science.gov (United States)

    Webb, Samuel J; Hanser, Thierry; Howlin, Brendan; Krause, Paul; Vessey, Jonathan D

    2014-03-25

    A new algorithm has been developed to enable the interpretation of black box models. The developed algorithm is agnostic to learning algorithm and open to all structural based descriptors such as fragments, keys and hashed fingerprints. The algorithm has provided meaningful interpretation of Ames mutagenicity predictions from both random forest and support vector machine models built on a variety of structural fingerprints.A fragmentation algorithm is utilised to investigate the model's behaviour on specific substructures present in the query. An output is formulated summarising causes of activation and deactivation. The algorithm is able to identify multiple causes of activation or deactivation in addition to identifying localised deactivations where the prediction for the query is active overall. No loss in performance is seen as there is no change in the prediction; the interpretation is produced directly on the model's behaviour for the specific query. Models have been built using multiple learning algorithms including support vector machine and random forest. The models were built on public Ames mutagenicity data and a variety of fingerprint descriptors were used. These models produced a good performance in both internal and external validation with accuracies around 82%. The models were used to evaluate the interpretation algorithm. Interpretation was revealed that links closely with understood mechanisms for Ames mutagenicity. This methodology allows for a greater utilisation of the predictions made by black box models and can expedite further study based on the output for a (quantitative) structure activity model. Additionally the algorithm could be utilised for chemical dataset investigation and knowledge extraction/human SAR development.

  3. High-speed research program systems analysis activities at Ames Research Center

    Science.gov (United States)

    Kidwell, George H.

    1992-01-01

    The Ames Systems Analysis Branch has been working to support the High Speed Research Program (HSRP) for nearly one year. Both the status of methodology development activities and the results of studies are presented whether completed or underway. The discussion involves the conceptual design synthesis program used for High Speed Civil Transport (HSCT) studies, ACSYNT (aircraft synthesis), and enhancements that have been made especially for HSRP. Some results are presented for one study that has been completed and two that are underway. These are the advanced controls integration study, the fuel cost impact study, and the oblique wing configuration evaluation that is part of a larger innovative concepts study.

  4. Comparison of Amerlex, NML, and Ames total thyroxine and triiodothyronine radioimmunoassay kits

    Energy Technology Data Exchange (ETDEWEB)

    Wilke, T J; Turnbull, P A [Commonwealth Pathology Lab., Toowoomba (Australia). Dept. of Endocrinology

    1982-03-01

    An evaluation of the Amerlex system for determination of total thyroxine (T4) and total triiodothyronine (T3) is described. The within- and between-batch precisions were acceptable, and analyses of quality control material and linearity studies demonstrated good accuracy at the clinical decision levels. The correlations obtained with NML and Ames T4 and T3 kit methods were highly significant. The Amerlex T4 and T3 methods are rapid, technically simple, and, coupled with excellent precision and accuracy, present significant advantages.

  5. Comparison of Amerlex, NML, and Ames total thyroxine and triiodothyronine radioimmunoassay kits

    International Nuclear Information System (INIS)

    Wilke, T.J.; Turnbull, P.A.

    1982-01-01

    An evaluation of the Amerlex system for determination of total thyroxine (T4) and total triiodothyronine (T3) is described. The within- and between-batch precisions were acceptable, and analyses of quality control material and linearity studies demonstrated good accuracy at the clinical decision levels. The correlations obtained with NML and Ames T4 and T3 kit methods were highly significant. The Amerlex T4 and T3 methods are rapid, technically simple, and, coupled with excellent precision and accuracy, present significant advantages. (author)

  6. Current Background Noise Sources and Levels in the NASA Ames 40- by 80-Foot Wind Tunnel: A Status Report

    Science.gov (United States)

    Allen, Christopher S.; Jaeger, Stephen; Soderman, Paul; Koga, Dennis (Technical Monitor)

    1999-01-01

    Background noise measurements were made of the acoustic environment in the National Full-Scale Aerodynamics Complex 40- by 80-Foot Wind Tunnel (40x80) at NASA Ames Research Center. The measurements were acquired subsequent to the 40x80 Aeroacoustic Modernization Project, which was undertaken to improve the anechoic characteristics of the 40x80's closed test section as well as reduce the levels of background noise in the facility. The resulting 40x80 anechoic environment was described by Soderman et. al., and the current paper describes the resulting 40x80 background noise, discusses the sources of the noise, and draws comparisons to previous 40x80 background noise levels measurements. At low wind speeds or low frequencies, the 40x80 background noise is dominated by the fan drive system. To obtain the lowest fan drive noise for a given tunnel condition, it is possible in the 40x80 to reduce the fans' rotational speed and adjust the fans' blade pitch, as described by Schmidtz et. al. This idea is not new, but has now been operationally implemented with modifications for increased power at low rotational speeds. At low to mid-frequencies and at higher wind speeds, the dominant noise mechanism was thought to be caused by the surface interface of the previous test section floor acoustic lining. In order to reduce this noise mechanism, the new test section floor lining was designed to resist the pumping of flow in and out of the space between the grating slats required to support heavy equipment. In addition, the lining/flow interface over the entire test section was designed to be smoother and quieter than the previous design. At high wind speeds or high frequencies, the dominant source of background noise in the 40x80 is believed to be caused by the response of the in-flow microphone probes (required by the nature of the closed test section) to the fluctuations in the freestream flow. The resulting background noise levels are also different for probes of various

  7. Low body temperature in long-lived Ames dwarf mice at rest and during stress.

    Science.gov (United States)

    Hunter, W S; Croson, W B; Bartke, A; Gentry, M V; Meliska, C J

    1999-09-01

    Among homeothermic animals, larger species generally have lower metabolic rates and live longer than do smaller species. Because Ames dwarf mice (dwarfs) live approximately 1 year longer than their larger normal sex- and age-matched siblings (normals), we hypothesized that they would have lower body core temperature (Tco). We, therefore, measured Tco of six dwarfs and six normals during 24-h periods of ad lib feeding, 24-h food deprivation, and emotional stress induced by cage switching. With ad lib feeding, Tco of dwarfs averaged 1.6 degrees C lower than normals; during food deprivation, Tco of both dwarfs and controls was significantly lower than when food was available ad lib; and following cage switch, Tco was elevated in both groups. However, during all three experiments, Tco was significantly lower in dwarfs than in normals. These data support the hypothesis that Ames dwarf mice, which live longer than normal size controls, maintain lower Tco than normals. Because dwarfs are deficient in thyroid stimulating hormone (TSH) and growth hormone (GH), their low Tco may be a result of reduced thermogenesis due to lack of those hormones. However, whether low Tco per se is related to the increased longevity of the dwarf mice remains an interesting possibility to be investigated.

  8. Thyroxine modifies the effects of growth hormone in Ames dwarf mice.

    Science.gov (United States)

    Do, Andrew; Menon, Vinal; Zhi, Xu; Gesing, Adam; Wiesenborn, Denise S; Spong, Adam; Sun, Liou; Bartke, Andrzej; Masternak, Michal M

    2015-04-01

    Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early-life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male dwarfs with GH + T4 between the ages of 2 and 8 weeks rescued somatic growth yet did not reduce lifespan to match normal controls, thus contrasting with the previously reported effects of GH alone. While the male dwarf GH + T4 treatment group had no significant effect on lifespan, the female dwarfs undergoing treatment showed a decrease in maximal longevity. Expression of genes related to GH and insulin signaling in the skeletal muscle and white adipose tissue (WAT) of female dwarfs was differentially affected by treatment with GH + T4 vs. GH alone. Differences in the effects of GH + T4 vs. GH alone on insulin target tissues may contribute to the differential effects of these treatments on longevity.

  9. Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay.

    Science.gov (United States)

    Sharif, Ali; Akhtar, Muhammad Furqan; Akhtar, Bushra; Saleem, Ammara; Manan, Maria; Shabbir, Maryam; Ashraf, Muneeb; Peerzada, Sohaib; Ahmed, Shoaib; Raza, Moosa

    2017-01-01

    Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic potential using Ames assay and cytotoxicity was evaluated using MTT assay. Ames assay was conducted using two strains of Salmonella typhimurium TA-100 and TA-102 whereas MTT assay was performed on baby hamster kidney cell line BHK-21. Aqua-methanolic extract of K. laciniata exhibited significant mutagenicity when exposed to TA-102 strain with a mutagenic index of 50.66 and 54.74 at maximum dose 150 mg/plate. The extract was also mutagenic to TA-100 strain but to a lesser extent. M.I of n-hexane extract was 12.15 and 15.51 for TA-100 and TA-102 respectively. n-hexane extract was mutagenic but little difference was observed between results of two strains. Both extracts were found to be cytotoxic with an IC 50 of 321.9 and 638.5 µg/mL for aqua-methanolic and n-hexane extracts respectively. On the basis of results it was concluded that aqua-methanolic and n-hexane extracts of K. laciniata possess mutagenic and cytotoxic potential. It is suggested to explore the plant further to evaluate its safety in rodents and other species.

  10. Assessment of diphenylcyclopropenone for photochemically induced mutagenicity in the Ames assay

    Energy Technology Data Exchange (ETDEWEB)

    Wilkerson, M.G.; Connor, T.H.; Henkin, J.; Wilkin, J.K.; Matney, T.S.

    1987-10-01

    The photochemical conversion of diphenylcyclopropenone to diphenylacetylene has recently been reported. Diphenylcyclopropenone is used in the treatment of alopecia areata and is nonmutagenic in a limited Ames assay. We examined diphenylcyclopropenone and diphenylacetylene, as well as synthetic precursors of diphenylcyclopropenone--dibenzylketone and alpha,alpha'-dibromodibenzylketone--for mutagenicity against TA100, TA98, TA102, UTH8413, and UTH8414. All compounds were nonmutagenic except alpha,alpha'-dibromodibenzylketone, which was a potent mutagen in TA100 with and without S-9 activation. The effect of photochemical activation of diphenylcyclopropenone in the presence of bacteria demonstrated mutagenicity in UTH8413 (two times background) at 10 micrograms/plate with S-9 microsomal activation. 8-Methoxypsoralen produces a mutagenic response in TA102 at 0.1 microgram/plate with 60 seconds of exposure to 350 nm light. In vitro photochemically activated Ames assay with S-9 microsomal fraction may enhance the trapping of short-lived photochemically produced high-energy mutagenic intermediates. This technique offers exciting opportunities to trap high-energy intermediates that may play an important role in mutagenesis. This method can be applied to a variety of topically applied dermatologic agents, potentially subjected to photochemical changes in normal use.

  11. Investigating the intra-nuclear cascade process using the reaction 136Xe on deuterium at 500 AMeV

    Directory of Open Access Journals (Sweden)

    Rejmund F.

    2010-10-01

    Full Text Available More than 600 residual nuclei, formed in the spallation of 136Xe projectiles impinging on deuterium at 500 AMeV of incident energy, have been unambiguously identified and their production cross sections have been determined with high accuracy. By comparing these data to others previously measured for the reactions 136Xe  +  p at 1 AGeV and 136Xe  +  p at 500 AMeV we investigated the role that neutrons play in peripheral collisions and to understand the energy dissipation in frontal collisions in spallation reactions.

  12. Wind-tunnel investigation of a large-scale VTOL aircraft model with wing root and wing thrust augmentors. [Ames 40 by 80 foot wind tunnel

    Science.gov (United States)

    Aoyagi, K.; Aiken, T. N.

    1979-01-01

    Tests were conducted in the Ames 40 by 80 foot wind tunnel to determine the aerodynamic characteristics of a large-scale V/STOL aircraft model with thrust augmentors. The model had a double-delta wing of aspect ratio 1.65 with augmentors located in the wing root and the wing trailing edge. The supply air for the augmentor primary nozzles was provided by the YJ-97 turbojet engine. The airflow was apportioned approximately 74 percent to the wing root augmentor and 24 percent to wing augmentor. Results were obtained at several trailing-edge flap deflections with the nozzle jet-momentum coefficients ranging from 0 to 7.9. Three-component longitudinal data are presented with the agumentor operating with and without the horizontal tail. A limited amount of six component data are also presented.

  13. Development and operation of a real-time simulation at the NASA Ames Vertical Motion Simulator

    Science.gov (United States)

    Sweeney, Christopher; Sheppard, Shirin; Chetelat, Monique

    1993-01-01

    The Vertical Motion Simulator (VMS) facility at the NASA Ames Research Center combines the largest vertical motion capability in the world with a flexible real-time operating system allowing research to be conducted quickly and effectively. Due to the diverse nature of the aircraft simulated and the large number of simulations conducted annually, the challenge for the simulation engineer is to develop an accurate real-time simulation in a timely, efficient manner. The SimLab facility and the software tools necessary for an operating simulation will be discussed. Subsequent sections will describe the development process through operation of the simulation; this includes acceptance of the model, validation, integration and production phases.

  14. Development of Implicit Methods in CFD NASA Ames Research Center 1970's - 1980's

    Science.gov (United States)

    Pulliam, Thomas H.

    2010-01-01

    The focus here is on the early development (mid 1970's-1980's) at NASA Ames Research Center of implicit methods in Computational Fluid Dynamics (CFD). A class of implicit finite difference schemes of the Beam and Warming approximate factorization type will be addressed. The emphasis will be on the Euler equations. A review of material pertinent to the solution of the Euler equations within the framework of implicit methods will be presented. The eigensystem of the equations will be used extensively in developing a framework for various methods applied to the Euler equations. The development and analysis of various aspects of this class of schemes will be given along with the motivations behind many of the choices. Various acceleration and efficiency modifications such as matrix reduction, diagonalization and flux split schemes will be presented.

  15. Prominent transverse flow of clusters in stopped Au(150AMeV)+Au reactions

    International Nuclear Information System (INIS)

    Coffin, J.P.; Kuhn, C.; Roy, C.; Cerruti, C.; Crochet, P.; Fintz, P.; Guillaume, G.; Houari, A.; Jundt, F.; Rami, F.; Tizniti, L.; Wagner, P.; Konopka, J.; Stoecker, H.

    1995-01-01

    Stopped Au(150AMeV)+Au collisions have been measured with the FOPI-Detector at GSI by imposing an upper limit on the ratio of the global longitudinal momentum to the collected charge within an event. The ejectiles, in particular those with Z>3, have a rapidity close to mid-rapidity and exhibit angular distributions in the centre-of-mass strongly peaking around 90 thus suggesting an enhancement of the flow in the transverse direction. Fits to the data and comparisons with QMD calculations indicate an averaged collective velocity in the transverse direction equal to 0.12c. Significance of the determined velocity and temperature values is discussed. ((orig.))

  16. New Diagnostic, Launch and Model Control Techniques in the NASA Ames HFFAF Ballistic Range

    Science.gov (United States)

    Bogdanoff, David W.

    2012-01-01

    This report presents new diagnostic, launch and model control techniques used in the NASA Ames HFFAF ballistic range. High speed movies were used to view the sabot separation process and the passage of the model through the model splap paper. Cavities in the rear of the sabot, to catch the muzzle blast of the gun, were used to control sabot finger separation angles and distances. Inserts were installed in the powder chamber to greatly reduce the ullage volume (empty space) in the chamber. This resulted in much more complete and repeatable combustion of the powder and hence, in much more repeatable muzzle velocities. Sheets of paper or cardstock, impacting one half of the model, were used to control the amplitudes of the model pitch oscillations.

  17. The Intermediate Velocity Source in the 40Ca + 197Au Reaction at 35 AMeV

    International Nuclear Information System (INIS)

    Planeta, R.; Sosin, Z.; Hachaj, P.

    2001-01-01

    The creation of hot Ca-like fragments and the emission of intermediate velocity particles was studied in the 40 Ca+ 197 Au reaction at 35 AMeV. For peripheral collisions the primary projectile-like fragment was reconstructed using the AMPHORA 4π detector system. The particle distributions are compared with the predictions of a Monte Carlo code which calculates the nucleon transfer and clustering probabilities according to the system density of states. The velocity distributions of charged particles projected on the beam direction can be explained if emissions from the hot projectile-like fragment and the target-like fragment are supplemented by an emission from an intermediate velocity source located between them. The properties of the intermediate velocity source are properly described, including the 2 D/ 3 T/ 3 He effect. (author)

  18. Updates on Modeling the Water Cycle with the NASA Ames Mars Global Climate Model

    Science.gov (United States)

    Kahre, M. A.; Haberle, R. M.; Hollingsworth, J. L.; Montmessin, F.; Brecht, A. S.; Urata, R.; Klassen, D. R.; Wolff, M. J.

    2017-01-01

    Global Circulation Models (GCMs) have made steady progress in simulating the current Mars water cycle. It is now widely recognized that clouds are a critical component that can significantly affect the nature of the simulated water cycle. Two processes in particular are key to implementing clouds in a GCM: the microphysical processes of formation and dissipation, and their radiative effects on heating/ cooling rates. Together, these processes alter the thermal structure, change the dynamics, and regulate inter-hemispheric transport. We have made considerable progress representing these processes in the NASA Ames GCM, particularly in the presence of radiatively active water ice clouds. We present the current state of our group's water cycle modeling efforts, show results from selected simulations, highlight some of the issues, and discuss avenues for further investigation.­

  19. X-ray K-edge analysis of drain lines in Wilhelm Hall, Ames Laboratory

    International Nuclear Information System (INIS)

    Jensen, T.; Whitmore, C.; Iowa State Univ., Ames, IA

    1999-01-01

    From August 12--27, 1998 X-ray K-edge measurements were made on drain lines in seven rooms in Wilhelm Hall, Ames Laboratory. The purpose of these measurements was to determine the extent of thorium (and other heavy metal) contamination inside these pipes. The K-edge method is a noninvasive inspection technique that can provide accurate quantification of heavy metal contamination interior to an object. Of the seven drain lines inspected, one was found to have no significant contamination, three showed significant thorium deposits, two showed mercury contamination, and one line was found to contain mercury, thorium and uranium. The K-edge measurements were found to be consistent with readings from hand-held survey meters, and provided much greater detail on the location and amount of heavy metal contamination

  20. How to write an educational research grant: AMEE Guide No. 101.

    Science.gov (United States)

    Blanco, Maria A; Gruppen, Larry D; Artino, Anthony R; Uijtdehaage, Sebastian; Szauter, Karen; Durning, Steven J

    2016-01-01

    Writing an educational research grant in health profession education is challenging, not only for those doing it for the first time but also for more experienced scholars. The intensity of the competition, the peculiarities of the grant format, the risk of rejection, and the time required are among the many obstacles that can prevent educational researchers with interesting and important ideas from writing a grant, that could provide the funding needed to turn their scholarly ideas into reality. The aim of this AMEE Guide is to clarify the grant-writing process by (a) explaining the mechanics and structure of a typical educational research grant proposal, and (b) sharing tips and strategies for making the process more manageable.

  1. Developing the Infrared PAH Emission Bands Into Calibrated Probes of Astrophysical Conditions with The NASA Ames PAH IR Spectroscopic Database

    Science.gov (United States)

    Boersma, Christiaan

    We propose to quantitatively calibrate the PAH band strength ratios that have been traditionally used as qualitative proxies of PAH properties and linking PAH observables with local astrophysical conditions, thus developing PAHs into quantitative probes of astronomical environments. This will culminate in a toolbox (calibration charts) that can be used by PAH experts and non-PAH experts alike to unlock the information hidden in PAH emission sources that are part of the Spitzer and ISO archives. Furthermore, the proposed work is critical to mine the treasure trove of information JWST will return as it will capture, for the first time, the complete mid-infrared (IR) PAH spectrum with fully resolved features, through a single aperture, and along single lines-of-sight; making it possible to fully extract the information contained in the PAH spectra. In short, the work proposed here represents a major step in enabling the astronomical PAH model to reach its full potential as a diagnostic of the physical and chemical conditions in objects spanning the Universe. Polycyclic aromatic hydrocarbons (PAHs), a common and important reservoir of accessible carbon across the Universe, play an intrinsic part in the formation of stars, planets and possibly even life itself. While most PAH spectra appear quite similar, they differ in detail and contain a wealth of untapped information. Thanks to recent advances in laboratory studies and computer-based calculations of PAH spectra, the majority of which have been made at NASA Ames, coupled with the astronomical modeling tools we have developed, we can interpret the spectral details at levels never before possible. This enables us to extract local physical conditions and track subtle changes in these conditions at levels previously impossible. Building upon the tools and paradigms developed as part of the publicly available NASA Ames PAH IR Spectroscopic Database (PAHdb; www.astrochem.org/pahdb/), the purpose of our proposed research is

  2. Piloted Evaluation of Modernized Limited Authority Control Laws in the NASA-Ames Vertical Motion Simulator (VMS)

    Science.gov (United States)

    Sahasrabudhe, Vineet; Melkers, Edgar; Faynberg, Alexander; Blanken, Chris L.

    2003-01-01

    The UH-60 BLACK HAWK was designed in the 1970s, when the US Army primarily operated during the day in good visual conditions. Subsequently, the introduction of night-vision goggles increased the BLACK HAWK'S mission effectiveness, but the accident rate also increased. The increased accident rate is strongly tied to increased pilot workload as a result of a degradation in visual cues. Over twenty years of research in helicopter flight control and handling qualities has shown that these degraded handling qualities can be recovered by modifying the response type of the helicopter in low speed flight. Sikorsky Aircraft Corporation initiated a project under the National Rotorcraft Technology Center (NRTC) to develop modern flight control laws while utilizing the existing partial authority Stability Augmentation System (SAS) of the BLACK HAWK. This effort resulted in a set of Modernized Control Laws (MCLAWS) that incorporate rate command and attitude command response types. Sikorsky and the US Army Aeroflightdynamics Directorate (AFDD) conducted a piloted simulation on the NASA-Ames Vertical h4otion Simulator, to assess potential handling qualities and to reduce the risk of subsequent implementation and flight test of these modern control laws on AFDD's EH-60L helicopter. The simulation showed that Attitude Command Attitude Hold control laws in pitch and roll improve handling qualities in the low speed flight regime. These improvements are consistent across a range of mission task elements and for both good and degraded visual environments. The MCLAWS perform better than the baseline UH-60A control laws in the presence of wind and turbulence. Finally, while the improved handling qualities in the pitch and roll axis allow the pilot to pay more attention to the vertical axis and hence altitude performance also improves, it is clear from pilot comments and altitude excursions that the addition of an Altitude Hold function would further reduce workload and improve overall

  3. Phenotypic Data Collection and Sample Preparation for Genomics of Wood Formation and Cellulosic Biomass Traits in Sunflower: Ames, IA location.

    Energy Technology Data Exchange (ETDEWEB)

    Marek, Laura F.

    2011-06-17

    Three fields were planted in Ames in 2010, two association mapping fields, N3 and A, and a recombinant inbred line field, N13. Phenotype data and images were transferred to UGA to support genetic and genomic analyses of woody biomass-related traits.

  4. Identification of a polyketide synthase required for alternariol (AOH and alternariol-9-methyl ether (AME formation in Alternaria alternata.

    Directory of Open Access Journals (Sweden)

    Debjani Saha

    Full Text Available Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH and alternariol-9-methyl ether (AME are important mycotoxins. Whereas the toxicology of these two polyketide-based compounds has been studied, nothing is known about the genetics of their biosynthesis. One of the postulated core enzymes in the biosynthesis of AOH and AME is polyketide synthase (PKS. In a draft genome sequence of A. alternata we identified 10 putative PKS-encoding genes. The timing of the expression of two PKS genes, pksJ and pksH, correlated with the production of AOH and AME. The PksJ and PksH proteins are predicted to be 2222 and 2821 amino acids in length, respectively. They are both iterative type I reducing polyketide synthases. PksJ harbors a peroxisomal targeting sequence at the C-terminus, suggesting that the biosynthesis occurs at least partly in these organelles. In the vicinity of pksJ we found a transcriptional regulator, altR, involved in pksJ induction and a putative methyl transferase, possibly responsible for AME formation. Downregulation of pksJ and altR caused a large decrease of alternariol formation, suggesting that PksJ is the polyketide synthase required for the postulated Claisen condensations during the biosynthesis. No other enzymes appeared to be required. PksH downregulation affected pksJ expression and thus caused an indirect effect on AOH production.

  5. ASCORBIC ACID REDUCTION OF ACTIVE CHLORINE PRIOR TO DETERMINING AMES MUTAGENICITY OF CHLORINATED NATURAL ORGANIC MATTER (NOM)

    Science.gov (United States)

    Many potable water disinfection byproducts (DBPs) that result from the reaction of natural organic matter (NOM) with oxidizing chlorine are known or suspected to be carcinogenic and mutagenic. The Ames assay is routinely used to assess an overall level of mutagenicity for all com...

  6. Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.

    Science.gov (United States)

    Rojanathammanee, Lalida; Rakoczy, Sharlene; Brown-Borg, Holly M

    2014-10-01

    Ames dwarf mice are deficient in growth hormone (GH), prolactin, and thyroid-stimulating hormone and live significantly longer than their wild-type (WT) siblings. The lack of GH is associated with stress resistance and increased longevity. However, the mechanism underlying GH's actions on cellular stress defense have yet to be elucidated. In this study, WT or Ames dwarf mice were treated with saline or GH (WT saline, Dwarf saline, and Dwarf GH) two times daily for 7 days. The body and liver weights of Ames dwarf mice were significantly increased after 7 days of GH administration. Mitochondrial protein levels of the glutathione S-transferase (GST) isozymes, K1 and M4 (GSTK1 and GSTM4), were significantly higher in dwarf mice (Dwarf saline) when compared with WT mice (WT saline). GH administration downregulated the expression of GSTK1 proteins in dwarf mice. We further investigated GST activity from liver lysates using different substrates. Substrate-specific GST activity (bromosulfophthalein, dichloronitrobenzene, and 4-hydrox-ynonenal) was significantly reduced in GH-treated dwarf mice. In addition, GH treatment attenuated the activity of thioredoxin and glutaredoxin in liver mitochondria of Ames mice. Importantly, GH treatment suppressed Trx2 and TrxR2 mRNA expression. These data indicate that GH has a role in stress resistance by altering the functional capacity of the GST system through the regulation of specific GST family members in long-living Ames dwarf mice. It also affects the regulation of thioredoxin and glutaredoxin, factors that regulate posttranslational modification of proteins and redox balance, thereby further influencing stress resistance. © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. Aeroacoustic Study of a 26%-Scale Semispan Model of a Boeing 777 Wing in the NASA Ames 40- by 80-Foot Wind Tunnel

    Science.gov (United States)

    Horne, W. Clifton; Burnside, Nathan J.; Soderman, Paul T.; Jaeger, Stephen M.; Reinero, Bryan R.; James, Kevin D.; Arledge, Thomas K.

    2004-01-01

    An acoustic and aerodynamic study was made of a 26%-scale unpowered Boeing 777 aircraft semispan model in the NASA Ames 40- by 80-Foot Wind Tunnel for the purpose of identifying and attenuating airframe noise sources. Simulated approach and landing configurations were evaluated at Mach numbers between 0.12 and 0.24. Cruise configurations were evaluated at Mach numbers between 0.24 and 0.33. The research team used two Ames phased-microphone arrays, a large fixed array and a small traversing array, mounted under the wing to locate and compare various noise sources in the wing high-lift system and landing gear. Numerous model modifications and noise alleviation devices were evaluated. Simultaneous with acoustic measurements, aerodynamic forces were recorded to document aircraft conditions and any performance changes caused by the geometric modifications. Numerous airframe noise sources were identified that might be important factors in the approach and landing noise of the full-scale aircraft. Several noise-control devices were applied to each noise source. The devices were chosen to manipulate and control, if possible, the flow around the various tips and through the various gaps of the high-lift system so as to minimize the noise generation. Fences, fairings, tip extensions, cove fillers, vortex generators, hole coverings, and boundary-layer trips were tested. In many cases, the noise-control devices eliminated noise from some sources at specific frequencies. When scaled to full-scale third-octave bands, typical noise reductions ranged from 1 to 10 dB without significant aerodynamic performance loss.

  8. Transforming BIM to BEM: Generation of Building Geometry for the NASA Ames Sustainability Base BIM

    Energy Technology Data Exchange (ETDEWEB)

    O' Donnell, James T. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Maile, Tobias [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rose, Cody [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mrazovic, Natasa [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Morrissey, Elmer [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Regnier, Cynthia [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Parrish, Kristen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bazjanac, Vladimir [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2013-01-01

    Typical processes of whole Building Energy simulation Model (BEM) generation are subjective, labor intensive, time intensive and error prone. Essentially, these typical processes reproduce already existing data, i.e. building models already created by the architect. Accordingly, Lawrence Berkeley National Laboratory (LBNL) developed a semi-automated process that enables reproducible conversions of Building Information Model (BIM) representations of building geometry into a format required by building energy modeling (BEM) tools. This is a generic process that may be applied to all building energy modeling tools but to date has only been used for EnergyPlus. This report describes and demonstrates each stage in the semi-automated process for building geometry using the recently constructed NASA Ames Sustainability Base throughout. This example uses ArchiCAD (Graphisoft, 2012) as the originating CAD tool and EnergyPlus as the concluding whole building energy simulation tool. It is important to note that the process is also applicable for professionals that use other CAD tools such as Revit (“Revit Architecture,” 2012) and DProfiler (Beck Technology, 2012) and can be extended to provide geometry definitions for BEM tools other than EnergyPlus. Geometry Simplification Tool (GST) was used during the NASA Ames project and was the enabling software that facilitated semi-automated data transformations. GST has now been superseded by Space Boundary Tool (SBT-1) and will be referred to as SBT-1 throughout this report. The benefits of this semi-automated process are fourfold: 1) reduce the amount of time and cost required to develop a whole building energy simulation model, 2) enable rapid generation of design alternatives, 3) improve the accuracy of BEMs and 4) result in significantly better performing buildings with significantly lower energy consumption than those created using the traditional design process, especially if the simulation model was used as a predictive

  9. Collective effects in Au(100-800 AMeV) + Au semi-central collisions; Effets collectifs dans les collisions semi-centrales Au(100-800 AMeV) + Au

    Energy Technology Data Exchange (ETDEWEB)

    Crochet, P.

    1996-04-04

    The present work has been carried out in the framework of the experimental program of the FOPI collaboration. It is devoted to a systematic study of the different forms of collective expansion of nuclear matter in semi-central Au+Au collisions at incident energies ranging from 100 AMeV to 800 AMeV. The aim is to investigate the influence of compressional effects, momentum dependence of the nuclear interaction and nucleon-nucleon cross section on the observed phenomena. Important changes in the reaction mechanisms are evidenced, in particular at low incident energies where one observes, on the one hand, a transition from an enhanced in-plane emission to a preferential out-of-plane emission pattern and, on the other hand, a strong reduction of the directed in-plane component. Experimental results are compared to the predictions of the Quantum Molecular Dynamics (QMD) model for different parametrizations of the nuclear interaction. (author).

  10. Model Deformation Measurements of Sonic Boom Models in the NASA Ames 9- by 7-Ft Supersonic Wind Tunnel

    Science.gov (United States)

    Schairer, Edward T.; Kushner, Laura K.; Garbeff, Theodore J.; Heineck, James T.

    2015-01-01

    The deformations of two sonic-boom models were measured by stereo photogrammetry during tests in the 9- by 7-Ft Supersonic Wind Tunnel at NASA Ames Research Center. The models were geometrically similar but one was 2.75 times as large as the other. Deformation measurements were made by simultaneously imaging the upper surfaces of the models from two directions by calibrated cameras that were mounted behind windows of the test section. Bending and twist were measured at discrete points using conventional circular targets that had been marked along the leading and trailing edges of the wings and tails. In addition, continuous distributions of bending and twist were measured from ink speckles that had been applied to the upper surfaces of the model. Measurements were made at wind-on (M = 1.6) and wind-off conditions over a range of angles of attack between 2.5 deg. and 5.0 deg. At each condition, model deformation was determined by comparing the wind-off and wind-on coordinates of each measurement point after transforming the coordinates to reference coordinates tied to the model. The necessary transformations were determined by measuring the positions of a set of targets on the rigid center-body of the models whose model-axes coordinates were known. Smoothly varying bending and twist measurements were obtained at all conditions. Bending displacements increased in proportion to the square of the distance to the centerline. Maximum deflection of the wingtip of the larger model was about 5 mm (2% of the semispan) and that of the smaller model was 0.9 mm (1% of the semispan). The change in wing twist due to bending increased in direct proportion to distance from the centerline and reached a (absolute) maximum of about -1? at the highest angle of attack for both models. The measurements easily resolved bending displacements as small as 0.05 mm and bending-induced changes in twist as small as 0.05 deg.

  11. Testing and evaluation of light ablation decontamination

    International Nuclear Information System (INIS)

    Demmer, R.L.; Ferguson, R.L.

    1994-10-01

    This report details the testing and evaluation of light ablation decontamination. It details WINCO contracted research and application of light ablation efforts by Ames Laboratory. Tests were conducted with SIMCON (simulated contamination) coupons and REALCON (actual radioactive metal coupons) under controlled conditions to compare cleaning effectiveness, speed and application to plant process type equipment

  12. Biological assays for aquatic toxicity testing

    CSIR Research Space (South Africa)

    Slabbert, JL

    1999-10-01

    Full Text Available and management purposes of effluents. If receiving water is used for drinking water purposes, the Ames Salmonella mutagenicity and toad embryo teratogenicity tests should be included in the battery of tests. Some of the rapid microbiotests, the petrozoan oxygen...

  13. Test

    DEFF Research Database (Denmark)

    Bendixen, Carsten

    2014-01-01

    Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers.......Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers....

  14. Scholarship, publication, and career advancement in health professions education: AMEE Guide No. 43.

    Science.gov (United States)

    McGaghie, William C

    2009-07-01

    Scholarship and publication are key contributors to career advancement in health professions education worldwide. Scholarship is expressed in many ways including original research; integration and synthesis of ideas and data, often across disciplines; application of skill and knowledge to problems that have consequences for health professionals, students, and patients; and teaching in many forms. Professional publication also has diverse outlets ranging from empirical articles in peer reviewed journals, textbook chapters, videos, simulation technologies, and many other means of expression. Scholarship and publication are evaluated and judged using criteria that are consensual, public, and transparent. This three-part AMEE Guide presents advice about how to prepare and publish health professions education research reports and other forms of scholarship in professional journals and other outlets. Part One addresses scholarship-its varieties, assessment, and attributes of productive scholars and scholarly teams. Part Two maps the road to publication, beginning with what's important and reportable and moving to manuscript planning and writing, gauging manuscript quality, manuscript submission and review, and writing in English. Part Three offers 21 practical suggestions about how to advance a successful and satisfying career in the academic health professions. Concluding remarks encourage health professions educators to pursue scholarship with vision and reflection.

  15. Radiation-induced mutagenicity and lethality in Ames tester strains of Salmonella

    International Nuclear Information System (INIS)

    Isildar, M.; Bakale, G.

    1984-01-01

    Mutation and killing induced by X radiation and 60 Co γ radiation were studied in six different histidine-requiring auxotrophs of Salmonella typhimurium. Strain TA100, which is sensitive to base-pair substitutions, and strains TA2637 and TA98, which are sensitive to frameshifts, carry the pKM101 plasmid and exhibit significantly higher radiation-induced mutations compared to their plasmidless parent strains TA1535, TA1537, and TA1538, respectively. Among the plasmid-containing strains, TA98 and TA2637 are much more sensitive to the mutagenic action of radiation than is TA100 based on a comparison with their respective spontaneous mutation rates; however, no uniformity was observed in the responses of the strains to the lethal action of ionizing radiation. The following conclusions are consistent with these observations: (1) the standard Ames Salmonella assay correctly identifies ionizing radiation as a mutagenic agent; (2) frameshift-sensitive parent strains are more sensitive to the mutagenic effects of ionizing radiation than is the only strain studied that is sensitive to base-pair substitutions; and (3) enhancement of mutagenesis and survival is related to plasmid-mediated repair of DNA damage induced by ionizing radiation and does not involve damage induced by Cerenkov-generated uv radiation which is negligible for our irradiation conditions

  16. Ames expedited site characterization demonstration at the former manufactured gas plant site, Marshalltown, Iowa

    International Nuclear Information System (INIS)

    Bevolo, A.J.; Kjartanson, B.H.; Wonder, J.D.

    1996-03-01

    The goal of the Ames Expedited Site Characterization (ESC) project is to evaluate and promote both innovative technologies (IT) and state-of-the-practice technologies (SOPT) for site characterization and monitoring. In April and May 1994, the ESC project conducted site characterization, technology comparison, and stakeholder demonstration activities at a former manufactured gas plant (FMGP) owned by Iowa Electric Services (IES) Utilities, Inc., in Marshalltown, Iowa. Three areas of technology were fielded at the Marshalltown FMGP site: geophysical, analytical and data integration. The geophysical technologies are designed to assess the subsurface geological conditions so that the location, fate and transport of the target contaminants may be assessed and forecasted. The analytical technologies/methods are designed to detect and quantify the target contaminants. The data integration technology area consists of hardware and software systems designed to integrate all the site information compiled and collected into a conceptual site model on a daily basis at the site; this conceptual model then becomes the decision-support tool. Simultaneous fielding of different methods within each of the three areas of technology provided data for direct comparison of the technologies fielded, both SOPT and IT. This document reports the results of the site characterization, technology comparison, and ESC demonstration activities associated with the Marshalltown FMGP site. 124 figs., 27 tabs

  17. Training for life science experiments in space at the NASA Ames Research Center

    Science.gov (United States)

    Rodrigues, Annette T.; Maese, A. Christopher

    1993-01-01

    As this country prepares for exploration to other planets, the need to understand the affects of long duration exposure to microgravity is evident. The National Aeronautics and Space Administration (NASA) Ames Research Center's Space Life Sciences Payloads Office is responsible for a number of non-human life sciences payloads on NASA's Space Shuttle's Spacelab. Included in this responsibility is the training of those individuals who will be conducting the experiments during flight, the astronauts. Preparing a crew to conduct such experiments requires training protocols that build on simple tasks. Once a defined degree of performance proficiency is met for each task, these tasks are combined to increase the complexity of the activities. As tasks are combined into in-flight operations, they are subjected to time constraints and the crew enhances their skills through repetition. The science objectives must be completely understood by the crew and are critical to the overall training program. Completion of the in-flight activities is proof of success. Because the crew is exposed to the background of early research and plans for post-flight analyses, they have a vested interest in the flight activities. The salient features of this training approach is that it allows for flexibility in implementation, consideration of individual differences, and a greater ability to retain experiment information. This training approach offers another effective alternative training tool to existing methodologies.

  18. Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.

    Science.gov (United States)

    Schneider, Augusto; Matkovich, Scot J; Saccon, Tatiana; Victoria, Berta; Spinel, Lina; Lavasani, Mitra; Bartke, Andrzej; Golusinski, Pawel; Masternak, Michal M

    2017-01-05

    The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Emission Spectroscopy and Radiometric Measurements in the NASA Ames IHF Arc Jet Facility

    Science.gov (United States)

    Winter, Michael W.; Raiche, George A.; Prabhu, Dinesh K.

    2012-01-01

    Plasma diagnostic measurement campaigns in the NASA Ames Interaction Heating Facility (IHF) have been conducted over the last several years with a view towards characterizing the flow in the arc jet facility by providing data necessary for modeling and simulation. Optical emission spectroscopy has been used in the plenum and in the free jet of the nozzle. Radiation incident over a probe surface has also been measured using radiometry. Plenum measurements have shown distinct radial profiles of temperature over a range of operating conditions. For cases where large amounts of cold air are added radially to the main arc-heated stream, the temperature profiles are higher by as much as 1500 K than the profiles assumed in flow simulations. Optical measurements perpendicular to the flow direction in the free jet showed significant contributions to the molecule emission through inverse pre-dissociation, thus allowing determination of atom number densities from molecular emission. This has been preliminarily demonstrated with the N2 1st Positive System. Despite the use of older rate coefficients, the resulting atom densities are reasonable and surprisingly close to flow predictions.

  20. Out-of-plane emission of nuclear matter in Au+Au collisions between 100 and 800 AMeV

    International Nuclear Information System (INIS)

    Bastid, N.; Buta, A.; Crochet, P.

    1996-01-01

    We present new experimental results concerning the azimuthal distributions of light and intermediate mass fragments at midrapidity for Au (100 - 800 AMeV) +Au collisions measured with the phase I setup of the FOPI detector at GSI in Darmstadt. The azimuthal distributions are investigated as a function of the collision centrality, the incident energy, the fragment charge and transverse momentum. The maximum of the azimuthal anisotropy is obtained for collisions associated with impact parameters around 7 fm. Intermediate mass fragments present a stronger out-of-plane emission signal that light fragments. We show in particular that the azimuthal anisotropy as a function of the scaled fragment transverse momentum follows an universal curve for incident energies ranging from 250 to 800 AMeV. A signature for a transition from in-plane to out-of-plane emission is evidenced at the lowest beam energies. (author)

  1. The Typical Different Features of Grammar of the British English (BrE and American English (AmE

    Directory of Open Access Journals (Sweden)

    I Wayan Dirgeyasa

    2016-08-01

    Full Text Available There are a number of varieties of English all over the world such as American, British, Australian, Indian, Singaporean, Philippine English, etc. However, there are only two varieties of English which are most widely and dominantly taught, learned, and used both spoken and printed around the world namely British English (BrE and American English (AmE. In real sense, the two are often confusing for the non-native learners because they have some differences and uniqueness in some aspects such as spelling, pronunciation, vocabulary, and grammar. Therefore, it is really important for students, teachers and speakers as well to be aware of the major differences between the two. This paper is trying to review some striking unique and different features of grammar of British English (BrE and American English (AmE.

  2. Out-of-plane emission of nuclear matter in Au+Au collisions between 100 and 800 AMeV

    Energy Technology Data Exchange (ETDEWEB)

    Bastid, N.; Buta, A.; Crochet, P. [and others; FOPI Collaboration

    1996-12-31

    We present new experimental results concerning the azimuthal distributions of light and intermediate mass fragments at midrapidity for Au (100 - 800 AMeV) +Au collisions measured with the phase I setup of the FOPI detector at GSI in Darmstadt. The azimuthal distributions are investigated as a function of the collision centrality, the incident energy, the fragment charge and transverse momentum. The maximum of the azimuthal anisotropy is obtained for collisions associated with impact parameters around 7 fm. Intermediate mass fragments present a stronger out-of-plane emission signal that light fragments. We show in particular that the azimuthal anisotropy as a function of the scaled fragment transverse momentum follows an universal curve for incident energies ranging from 250 to 800 AMeV. A signature for a transition from in-plane to out-of-plane emission is evidenced at the lowest beam energies. (author).

  3. Original Research: Metabolic alterations from early life thyroxine replacement therapy in male Ames dwarf mice are transient.

    Science.gov (United States)

    Darcy, Justin; Fang, Yimin; Hill, Cristal M; McFadden, Sam; Sun, Liou Y; Bartke, Andrzej

    2016-10-01

    Ames dwarf mice are exceptionally long-lived due to a Prop1 loss of function mutation resulting in deficiency of growth hormone, thyroid-stimulating hormone and prolactin. Deficiency in thyroid-stimulating hormone and growth hormone leads to greatly reduced levels of circulating thyroid hormones and insulin-like growth factor 1, as well as a reduction in insulin secretion. Early life growth hormone replacement therapy in Ames dwarf mice significantly shortens their longevity, while early life thyroxine (T4) replacement therapy does not. Possible mechanisms by which early life growth hormone replacement therapy shortens longevity include deleterious effects on glucose homeostasis and energy metabolism, which are long lasting. A mechanism explaining why early life T4 replacement therapy does not shorten longevity remains elusive. Here, we look for a possible explanation as to why early life T4 replacement therapy does not impact longevity of Ames dwarf mice. We found that early life T4 replacement therapy increased body weight and advanced the age of sexual maturation. We also find that early life T4 replacement therapy does not impact glucose tolerance or insulin sensitivity, and any deleterious effects on oxygen consumption, respiratory quotient and heat production are transient. Lastly, we find that early life T4 replacement therapy has long-lasting effects on bone mineral density and bone mineral content. We suggest that the transient effects on energy metabolism and lack of effects on glucose homeostasis are the reasons why there is no shortening of longevity after early life T4 replacement therapy in Ames dwarf mice. © 2016 by the Society for Experimental Biology and Medicine.

  4. Results of screening NCI/NTP nongenotoxic carcinogens and genotoxic noncarcinogens with the ke test

    International Nuclear Information System (INIS)

    Mendelsohn, M.L.; Bakale, G.; McCreary, R.D.

    1989-01-01

    The interdependence of the electrophilic and carcinogenic properties of chemicals that was demonstrated two decades ago rekindled interest in the somatic mutation theory of carcinogenesis. Interest in this theory grew with the development of a reverse-mutation bacterial assay in the laboratory of B.N. Ames that permitted the mutagenic properties of the chemicals to be determined quickly and yielded results which indicated that ''carcinogens are mutagens.'' Subsequent validation studies of this bioassay, the Salmonella typhimurium/microsome or ''Ames test,'' by Ames' group and others provided additional support for the correlation between mutagenicity and carcinogenicity which led to the worldwide deployment of the Ames test in thousands of laboratories and to the development of more than 100 other short-term tests that continue to be used to identify potential carcinogens via various end-points of genotoxicity. This document discusses electrophilicity, mutagenicity, and carcinogenicity relationships as well as carcinogen-screening of chemicals. 28 refs., 4 tabs

  5. Stereo Photogrammetry Measurements of the Position and Attitude of a Nozzle-Plume/Shock-Wave Interaction Model in the NASA Ames 9- by 7-Ft Supersonic Wind Tunnel

    Science.gov (United States)

    Schairer, Edward T.; Kushner, Laura K.; Drain, Bethany A.; Heineck, James T.; Durston, Donald A.

    2017-01-01

    Stereo photogrammetry was used to measure the position and attitude of a slender body of revolution during nozzle-plume/shock-wave interaction tests in the NASA Ames 9- by 7-Ft Supersonic Wind Tunnel. The model support system was designed to allow the model to be placed at many locations in the test section relative to a pressure rail on one sidewall. It included a streamwise traverse as well as a thin blade that offset the model axis from the sting axis. With these features the support system was more flexible than usual resulting in higher-than-usual uncertainty in the position and attitude of the model. Also contributing to this uncertainty were the absence of a balance, so corrections for sting deflections could not be applied, and the wings-vertical orientation of the model, which precluded using a gravity-based accelerometer to measure pitch angle. Therefore, stereo photogrammetry was chosen to provide independent measures of the model position and orientation. This paper describes the photogrammetry system and presents selected results from the test.

  6. Viking GCMS Data Restoral and Perceiving Temperature on Other Worlds: Astrobiology Projects at NASA Ames

    Science.gov (United States)

    Guzman, Melissa

    2015-01-01

    The primary task for the summer was to procure the GCMS data from the National Space Science Data Coordinated Archive (NSSDCA) and to assess the current state of the data set for possible reanalysis opportunities. After procurement of the Viking GCMS data set and analysis of its current state, the internship focus shifted to preparing a plan for restoral and archiving of the GCMS data set. A proposal was prepared and submitted to NASA Headquarters to restore and make available the 8000 mass chromatographs that are the basic data generated by the Viking GCMS instrument. The relevance of this restoral and the methodology we propose for restoral is presented. The secondary task for the summer is to develop a thermal model for the perceived temperature of a human standing on Mars, Titan, or Europa. Traditionally, an equation called "Fanger's comfort equation" is used to measure the perceived temperature by a human in a given reference environment. However, there are limitations to this model when applied to other planets. Therefore, the approach for this project has been to derive energy balance equations from first principles and then develop a methodology for correlating "comfort" to energy balance. Using the -20 C walk-in freezer in the Space Sciences building at NASA Ames, energy loss of a human subject is measured. Energy loss for a human being on Mars, Titan and Europa are calculated from first principles. These calculations are compared to the freezer measurements, e.g. for 1 minute on Titan, a human loses as much energy as x minutes in a -20 C freezer. This gives a numerical comparison between the environments. These energy calculations are used to consider the physiological comfort of a human based on the calculated energy losses.

  7. Simulating the Current Water Cycle with the NASA Ames Mars Global Climate Model

    Science.gov (United States)

    Kahre, M. A.; Haberle, R. M.; Hollingsworth, J. L.; Brecht, A. S.; Urata, R. A.; Montmessin, F.

    2017-12-01

    The water cycle is a critical component of the current Mars climate system, and it is now widely recognized that water ice clouds significantly affect the nature of the simulated water cycle. Two processes are key to implementing clouds in a Mars global climate model (GCM): the microphysical processes of formation and dissipation, and their radiative effects on atmospheric heating/cooling rates. Together, these processes alter the thermal structure, change the atmospheric dynamics, and regulate inter-hemispheric transport. We have made considerable progress using the NASA Ames Mars GCM to simulate the current-day water cycle with radiatively active clouds. Cloud fields from our baseline simulation are in generally good agreement with observations. The predicted seasonal extent and peak IR optical depths are consistent MGS/TES observations. Additionally, the thermal response to the clouds in the aphelion cloud belt (ACB) is generally consistent with observations and other climate model predictions. Notably, there is a distinct gap in the predicted clouds over the North Residual Cap (NRC) during local summer, but the clouds reappear in this simulation over the NRC earlier than the observations indicate. Polar clouds are predicted near the seasonal CO2 ice caps, but the column thicknesses of these clouds are generally too thick compared to observations. Our baseline simulation is dry compared to MGS/TES-observed water vapor abundances, particularly in the tropics and subtropics. These areas of disagreement appear to be a consistent with other current water cycle GCMs. Future avenues of investigation will target improving our understanding of what controls the vertical extent of clouds and the apparent seasonal evolution of cloud particle sizes within the ACB.

  8. MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging.

    Science.gov (United States)

    Bates, David J; Li, Na; Liang, Ruqiang; Sarojini, Harshini; An, Jin; Masternak, Michal M; Bartke, Andrzej; Wang, Eugenia

    2010-02-01

    The Ames dwarf mouse is well known for its remarkable propensity to delay the onset of aging. Although significant advances have been made demonstrating that this aging phenotype results primarily from an endocrine imbalance, the post-transcriptional regulation of gene expression and its impact on longevity remains to be explored. Towards this end, we present the first comprehensive study by microRNA (miRNA) microarray screening to identify dwarf-specific lead miRNAs, and investigate their roles as pivotal molecular regulators directing the long-lived phenotype. Mapping the signature miRNAs to the inversely expressed putative target genes, followed by in situ immunohistochemical staining and in vitro correlation assays, reveals that dwarf mice post-transcriptionally regulate key proteins of intermediate metabolism, most importantly the biosynthetic pathway involving ornithine decarboxylase and spermidine synthase. Functional assays using 3'-untranslated region reporter constructs in co-transfection experiments confirm that miRNA-27a indeed suppresses the expression of both of these proteins, marking them as probable targets of this miRNA in vivo. Moreover, the putative repressed action of this miRNA on ornithine decarboxylase is identified in dwarf mouse liver as early as 2 months of age. Taken together, our results show that among the altered aspects of intermediate metabolism detected in the dwarf mouse liver--glutathione metabolism, the urea cycle and polyamine biosynthesis--miRNA-27a is a key post-transcriptional control. Furthermore, compared to its normal siblings, the dwarf mouse exhibits a head start in regulating these pathways to control their normality, which may ultimately contribute to its extended health-span and longevity.

  9. Multiyear Simulations of the Martian Water Cycle with the Ames General Circulation Model

    Science.gov (United States)

    Haberle, R. M.; Schaeffer, J. R.; Nelli, S. M.; Murphy, J. R.

    2003-01-01

    Mars atmosphere is carbon dioxide dominated with non-negligible amounts of water vapor and suspended dust particles. The atmospheric dust plays an important role in the heating and cooling of the planet through absorption and emission of radiation. Small dust particles can potentially be carried to great altitudes and affect the temperatures there. Water vapor condensing onto the dust grains can affect the radiative properties of both, as well as their vertical extent. The condensation of water onto a dust grain will change the grain s fall speed and diminish the possibility of dust obtaining high altitudes. In this capacity, water becomes a controlling agent with regard to the vertical distribution of dust. Similarly, the atmosphere s water vapor holding capacity is affected by the amount of dust in the atmosphere. Dust is an excellent green house catalyst; it raises the temperature of the atmosphere, and thus, its water vapor holding capacity. There is, therefore, a potentially significant interplay between the Martian dust and water cycles. Previous research done using global, 3-D computer modeling to better understand the Martian atmosphere treat the dust and the water cycles as two separate and independent processes. The existing Ames numerical model will be employed to simulate the relationship between the Martian dust and water cycles by actually coupling the two cycles. Water will condense onto the dust, allowing the particle's radiative characteristics, fall speeds, and as a result, their vertical distribution to change. Data obtained from the Viking, Mars Pathfinder, and especially the Mars Global Surveyor missions will be used to determine the accuracy of the model results.

  10. The microRNA ame-miR-279a regulates sucrose responsiveness of forager honey bees (Apis mellifera).

    Science.gov (United States)

    Liu, Fang; Shi, Tengfei; Yin, Wei; Su, Xin; Qi, Lei; Huang, Zachary Y; Zhang, Shaowu; Yu, Linsheng

    2017-11-01

    Increasing evidence demonstrates that microRNAs (miRNA) play an important role in the regulation of animal behaviours. Honey bees (Apis mellifera) are eusocial insects, with honey bee workers displaying age-dependent behavioural maturation. Many different miRNAs have been implicated in the change of behaviours in honey bees and ame-miR-279a was previously shown to be more highly expressed in nurse bee heads than in those of foragers. However, it was not clear whether this difference in expression was associated with age or task performance. Here we show that ame-miR-279a shows significantly higher expression in the brains of nurse bees relative to forager bees regardless of their ages, and that ame-miR-279a is primarily localized in the Kenyon cells of the mushroom body in both foragers and nurses. Overexpression of ame-miR-279a attenuates the sucrose responsiveness of foragers, while its absence enhances their sucrose responsiveness. Lastly, we determined that ame-miR-279a directly target the mRNA of Mblk-1. These findings suggest that ame-miR-279a plays important roles in regulating honey bee division of labour. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. NMDA and kainate receptor expression, long-term potentiation, and neurogenesis in the hippocampus of long-lived Ames dwarf mice.

    Science.gov (United States)

    Sharma, Sunita; Darland, Diane; Lei, Saobo; Rakoczy, Sharlene; Brown-Borg, Holly M

    2012-06-01

    In the current study, we investigated changes in N-methyl D-aspartate (NMDA) and kainate receptor expression, long-term potentiation (LTP), and neurogenesis in response to neurotoxic stress in long-living Ames dwarf mice. We hypothesized that Ames dwarf mice have enhanced neurogenesis that enables retention of spatial learning and memory with age and promotes neurogenesis in response to injury. Levels of the NMDA receptors (NR)1, NR2A, NR2B, and the kainate receptor (KAR)2 were increased in Ames dwarf mice, relative to wild-type littermates. Quantitative assessment of the excitatory postsynaptic potential in Schaffer collaterals in hippocampal slices from Ames dwarf mice showed an increased response in high-frequency induced LTP over time compared with wild type. Kainic acid (KA) injection was used to promote neurotoxic stress-induced neurogenesis. KA mildly increased the number of doublecortin-positive neurons in wild-type mice, but the response was significantly enhanced in the Ames dwarf mice. Collectively, these data support our hypothesis that the enhanced learning and memory associated with the Ames dwarf mouse may be due to elevated levels of NMDA and KA receptors in hippocampus and their ability to continue producing new neurons in response to neuronal damage.

  12. Long-lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high-fat diet on metabolic function and energy expenditure.

    Science.gov (United States)

    Hill, Cristal M; Fang, Yimin; Miquet, Johanna G; Sun, Liou Y; Masternak, Michal M; Bartke, Andrzej

    2016-06-01

    Growth hormone (GH) signaling stimulates the production of IGF-1; however, increased GH signaling may induce insulin resistance and can reduce life expectancy in both mice and humans. Interestingly, disruption of GH signaling by reducing plasma GH levels significantly improves health span and extends lifespan in mice, as observed in Ames dwarf mice. In addition, these mice have increased adiposity, yet are more insulin sensitive compared to control mice. Metabolic stressors such as high-fat diet (HFD) promote obesity and may alter longevity through the GH signaling pathway. Therefore, our objective was to investigate the effects of a HFD (metabolic stressor) on genetic mechanisms that regulate metabolism during aging. We show that Ames dwarf mice fed HFD for 12 weeks had an increase in subcutaneous and visceral adiposity as a result of diet-induced obesity, yet are more insulin sensitive and have higher levels of adiponectin compared to control mice fed HFD. Furthermore, energy expenditure was higher in Ames dwarf mice fed HFD than in control mice fed HFD. Additionally, we show that transplant of epididymal white adipose tissue (eWAT) from Ames dwarf mice fed HFD into control mice fed HFD improves their insulin sensitivity. We conclude that Ames dwarf mice are resistant to the detrimental metabolic effects of HFD and that visceral adipose tissue of Ames dwarf mice improves insulin sensitivity in control mice fed HFD. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  13. Mutagenicity of Tween 80-solvated mild gasification products in the Ames salmonella microsomal assay system. [Quarterly report, October--December 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-13

    The results of the Tween 80-solvated Ames testing of six mild gasification samples indicate significant mutagenic activity only in the composite materials (MG-119 and MG-120), previously suspected from the DMSO-solvated assays, which had shown some variable but ultimately insignificant mutagenic responses. The activity of these samples from the Tween 80-solvated assays was quite low when compared to either the positive controls or the SRC-II HD coal-liquefaction reference material. The class of mutagenic activity expressed by these samples solvated in Tween 80 was that of an indirect-acting, frameshift mutagen(s) since significant activity was found only on tester strain TA98 in the presence of the metabolic activation fraction (S9). Because DMSO and other solvents have been shown to affect the mutagenic activity of certain pure chemicals, the possibility of solvent/mutagen interactions in complex mixtures such as coal-derived liquids exists. Thus, the testing of the genotoxic activity of undefined, chemically complex compounds may require the use of at least two solvent systems to reduce the possibility of artifactual findings. 10 refs., 4 tabs.

  14. Recent Progress in Planetary Laboratory Astrophysics achieved with NASA Ames' COSmIC Facility

    Science.gov (United States)

    Salama, Farid; Sciamma-O'Brien, Ella; Bejaoui, Salma

    2016-10-01

    We describe the characteristics and the capabilities of the laboratory facility, COSmIC, that was developed at NASA Ames to generate, process and analyze interstellar, circumstellar and planetary analogs in the laboratory [1]. COSmIC stands for "Cosmic Simulation Chamber" and is dedicated to the study of neutral and ionized molecules and nanoparticles under the low temperature and high vacuum conditions that are required to simulate various space environments such as planetary atmospheres. COSmIC integrates a variety of state-of-the-art instruments that allow forming, processing and monitoring simulated space conditions for planetary, circumstellar and interstellar materials in the laboratory. The COSmIC experimental setup is composed of a Pulsed Discharge Nozzle (PDN) expansion, that generates a plasma in the stream of a free supersonic jet expansion, coupled to two high-sensitivity, complementary in situ diagnostics: a Cavity Ring Down Spectroscopy (CRDS) and laser induced fluorescence (LIF) systems for photonic detection [2, 3], and a Reflectron Time-Of-Flight Mass Spectrometer (ReTOF-MS) for mass detection [4].Recent results obtained using COSmIC will be highlighted. In particular, the progress that has been achieved in an on-going study investigating the formation and the characterization of laboratory analogs of Titan's aerosols generated from gas-phase molecular precursors [5] will be presented. Plans for future laboratory experiments on planetary molecules and aerosols in the growing field of planetary laboratory astrophysics will also be addressed, as well as the implications of studies underway for astronomical observations.References: [1] Salama F., in Organic Matter in Space, IAU S251, Kwok & Sandford eds, CUP, S251, 4, 357 (2008).[2] Biennier L., Salama, F., Allamandola L., & Scherer J., J. Chem. Phys., 118, 7863 (2003)[3] Tan X, & Salama F., J. Chem. Phys. 122, 84318 (2005)[4] Ricketts C., Contreras C., Walker, R., Salama F., Int. J. Mass Spec, 300

  15. Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.

    Science.gov (United States)

    Gesing, Adam; Al-Regaiey, Khalid A; Bartke, Andrzej; Masternak, Michal M

    2014-10-01

    Disruption of the growth hormone (GH) axis promotes longevity and delays aging. In contrast, GH over-expression may lead to accelerated aging and shorter life. Calorie restriction (CR) improves insulin sensitivity and may extend lifespan. Long-lived Ames dwarf (df/df) mice have additional extension of longevity when subjected to 30% CR. The aim of the study was to assess effects of CR or GH replacement therapy separately and as a combined (CR+GH) treatment in GH-deficient df/df and normal mice, on selected metabolic parameters (e.g., insulin, glucose, cholesterol), insulin signaling components (e.g., insulin receptor [IR] β-subunit, phosphorylated form of IR [IR pY1158], protein kinase C ζ/λ [p-PKCζ/λ] and mTOR [p-mTOR]), transcription factor p-CREB, and components of the mitogen-activated protein kinase (MAPK) signaling (p-ERK1/2, p-p38), responsible for cell proliferation, differentiation and survival. CR decreased plasma levels of insulin, glucose, cholesterol and leptin, and increased hepatic IR β-subunit and IR pY1158 levels as well as IR, IRS-1 and GLUT-2 gene expression compared to ad libitum feeding, showing a significant beneficial diet intervention effect. Moreover, hepatic protein levels of p-PKCζ/λ, p-mTOR and p-p38 decreased, and p-CREB increased in CR mice. On the contrary, GH increased levels of glucose, cholesterol and leptin in plasma, and p-mTOR or p-p38 in livers, and decreased plasma adiponectin and hepatic IR β-subunit compared to saline treatment. There were no GH effects on adiponectin in N mice. Moreover, GH replacement therapy did not affect IR, IRS-1 and GLUT-2 gene expression. GH treatment abolishes the beneficial effects of CR; it may suggest an important role of GH-IGF1 axis in mediating the CR action. Suppressed somatotrophic signaling seems to predominate over GH replacement therapy in the context of the examined parameters and signaling pathways. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. AMEE Guide 32: e-Learning in medical education Part 1: Learning, teaching and assessment.

    Science.gov (United States)

    Ellaway, Rachel; Masters, Ken

    2008-06-01

    In just a few years, e-learning has become part of the mainstream in medical education. While e-learning means many things to many people, at its heart it is concerned with the educational uses of technology. For the purposes of this guide, we consider the many ways that the information revolution has affected and remediated the practice of healthcare teaching and learning. Deploying new technologies usually introduces tensions, and e-learning is no exception. Some wish to use it merely to perform pre-existing activities more efficiently or faster. Others pursue new ways of thinking and working that the use of such technology affords them. Simultaneously, while education, not technology, is the prime goal (and for healthcare, better patient outcomes), we are also aware that we cannot always predict outcomes. Sometimes, we have to take risks, and 'see what happens.' Serendipity often adds to the excitement of teaching. It certainly adds to the excitement of learning. The use of technology in support of education is not, therefore, a causal or engineered set of practices; rather, it requires creativity and adaptability in response to the specific and changing contexts in which it is used. Medical Education, as with most fields, is grappling with these tensions; the AMEE Guide to e-Learning in Medical Education hopes to help the reader, whether novice or expert, navigate them. This Guide is presented both as an introduction to the novice, and as a resource to more experienced practitioners. It covers a wide range of topics, some in broad outline, and others in more detail. Each section is concluded with a brief 'Take Home Message' which serves as a short summary of the section. The Guide is divided into two parts. The first part introduces the basic concepts of e-learning, e-teaching, and e-assessment, and then focuses on the day-to-day issues of e-learning, looking both at theoretical concepts and practical implementation issues. The second part examines technical

  17. AME survey-003 A1-part 2: the motivation factors of medical doctors in China.

    Science.gov (United States)

    Wáng, Yì-Xiáng J; Káplár, Zoltán; L, Yáo T

    2015-12-01

    The professional moral and job satisfaction of medical profession remain highly disputed in media in China. On the other hand, there is wide disaffection of patients toward doctors in China. This survey aims to obtain a better understanding of the motivation of Chinese medical professionals. An anonymous online cross-sectional survey, AME survey III, was conducted using the platform provided by DXY (www.dxy.cn) during the period of September 10-23, 2015. In total 2,356 DXY users completed the survey, including 1,740 males and 617 females, with a mean age of 31.96±7.03 yrs. The reasons (multiple choices) for career disaffection included poor patient/doctor relationship (88.6%), imbalance between workload and pay (79.5%), could not enter the preferred specialty (14.14%), and working in small clinics with no career progress (11.17%). If given the choice to enter the specialty as well as the hospital grade of their choice, 73.8% dissatisfied respondents replied they would like to be a doctor. For the dis-satisfied respondents, university teacher appeared to be the most popular career choice. The cited high workload was considered to be due to (I) imbalance in geographical allocation of doctors and insufficient training of doctors; (II) many red-tapism formalities; (III) Chinese patients often have unreasonable requests; (IV) over-examination and over-treatment; (V) high pressure to publish papers. One hundred and twelve respondents have their child/children attending university or graduated from university, 25.0% of them are pursuing a career in medicine. Nine hundred and ninety respondents have child/children while did not reach university age yet, among them 23.62% would like their child/children to study medicine. 64.87% of the 2,356 participants favor China to open up medical market to qualified foreign medical organizations to take part in fair competition, and 57.91% favor the government supporting regulated private hospitals. The moral and motivation of medical

  18. Investigations of the 0.020-scale 88-OTS Integrated Space Shuttle Vehicle Jet-Plume Model in the NASA/Ames Research Center 11 by11-Foot Unitary Plan Wind Tunnel (IA80). Volume 1

    Science.gov (United States)

    Nichols, M. E.

    1976-01-01

    The results are documented of jet plume effects wind tunnel test of the 0.020-scale 88-OTS launch configuration space shuttle vehicle model in the 11 x 11 foot leg of the NASA/Ames Research Center Unitary Plan Wind Tunnel. This test involved cold gas main propulsion system (MPS) and solid rocket motor (SRB) plume simulations at Mach numbers from 0.6 to 1.4. Integrated vehicle surface pressure distributions, elevon and rudder hinge moments, and wing and vertical tail root bending and torsional moments due to MPS and SRB plume interactions were determined. Nozzle power conditions were controlled per pretest nozzle calibrations. Model angle of attack was varied from -4 deg to +4 deg; model angle of sideslip was varied from -4 deg to +4 deg. Reynolds number was varied for certain test conditions and configurations, with the nominal freestream total pressure being 14.69 psia. Plotted force and pressure data are presented.

  19. Mutagenic activity of a fluorinated analog of the beta-adrenoceptor ligand carazolol in the Ames test

    NARCIS (Netherlands)

    Doze, P; Elsinga, PH; de Vries, EFJ; Van Waarde, A; Vaalburg, W

    S-1'[F-18]-Fluorocarazolol (FCAR) is a fluorinated analog of the nonmutagenic beta-blocker carazolol (CAR). Tn former studies FCAR proved to be suitable for quantification of beta-adrenoceptors in vivo with positron emission tomography (PET). We report here that FCAR displays no acute toxicity in

  20. Report on the Stanford/KACST/AMES UVLED small satellite mission to demonstrate charge management of an electrically isolated proof mass for drag-free operation

    Science.gov (United States)

    Saraf, Shailendhar

    A spacecraft demonstration of ultra-violet (UV) LEDs and UV LED charge management based on research done at Stanford University is being developed jointly by the King Abdulaziz City for Science and Technology (KACST) Saudi Arabia and NASA Ames Research Center, with an expected launch date of June 2014. This paper will report on the payload design and testing, mission preparation, satellite launch and payload bring -up in space. Mission lifetime is expected to be at least one month, during which time the ability for the UV LEDs to mitigate actual space-based charging and the effects of radiation on the UV LED device performance will be studied. Precise control over the potential of an electrically isolated proof mass is necessary for the operation of devices such as a Gravitational Reference Sensor (GRS) and satellite missions such as LISA. The mission will demonstrate that AlGaN UV LEDs operating at 255 nm are an effective low-cost, low-power and compact substitute for Mercury vapor lamps used in previous missions. The goal of the mission is to increase the UV LED device to TRL-9 and the charge management system to TRL-7.

  1. 2012 Ground Testing Highlights

    Science.gov (United States)

    Buchholz, Steven J.

    2012-01-01

    As part of the Fundamental Aeronautics Program and a collaborative effort with Boeing, and Lockheed Martin this past year a series of sonic boom test were completed in the NASA Ames Unitary Plan Wind Tunnel (UPWT). One of the goals was to develop new test techniques and hardware for measuring sonic boom signatures in the transonic and supersonic regimes. Data for various model designs and configurations were collected and will be used to validate CFD predictions of sonic boom signatures. Reactivation of the NASA Ames Mitsubishi compressor system was completed this past year. The compressor is intended to replace and augment the existing UPWT Clark Compressor as the primary Make Up Air (MUA) source. The MUA system provides air and vacuum pumping capability to the Ames UPWT. It will improve productivity and reliability of the UPWT as a vital testing and research facility for the U.S. aerospace industry and NASA. Funding for this task was provided from the American Recovery Investment Act (ARRA). Installation and validation of a Noncontact Stress Monitoring System (NSMS) for the 3-stage compressor was completed at the 11-foot Transonic Wind Tunnel. The system, originally developed at AEDC, consists of 36 pairs of LED light sources with optic beam send and receive probes along a 1-per rev signal. The new system allows for continuous monitoring and recording of compressor blade bending and torsion stress during normal test operations. A very unusual test was completed in the 11 FT TWT to acquire aerodynamic and flow field data for the Crew Exploration Vehicle (CEV) Parachute Assembly System (CPAS) to validate CFD methods and tools. Surface pressure distribution measurements and velocity measurements in the wake of the command module back to the drogues parachute location were acquired. Testing methods included Particle Image Velocimetry (PIV), Pressure Sensitive Paint (PSP), Schlieren Infrared Imaging (IR) and boundary layer survey and skin friction.

  2. Results of an investigation to determine local flow characteristics at the air data probe locations using an 0.030-scale model (45-0) of the space shuttle vehicle orbiter configuration 140A/B (modified) in the NASA Ames Research Center unitary plan wind tunnel (OA161, A, B, C), volume 1

    Science.gov (United States)

    Nichols, M. E.

    1976-01-01

    Results are presented of wind tunnel test 0A161 of a 0.030-scale model 45-0 of the configuration 140A/B (modified) space shuttle vehicle orbiter in the NASA Ames Research Center Unitary Plan Wind Tunnel facilities. The purpose of this test was to determine local total and static pressure environments for the air data probe locations and relative effectiveness of alternate flight-test probe configurations. Testing was done in the Mach number range from 0.30 to 3.5. Angle of attack was varied from -8 to 25 degrees while sideslip varied between -8 and 8 degrees.

  3. Flight research and testing

    Science.gov (United States)

    Putnam, Terrill W.; Ayers, Theodore G.

    1989-01-01

    Flight research and testing form a critical link in the aeronautic research and development chain. Brilliant concepts, elegant theories, and even sophisticated ground tests of flight vehicles are not sufficient to prove beyond a doubt that an unproven aeronautical concept will actually perform as predicted. Flight research and testing provide the ultimate proof that an idea or concept performs as expected. Ever since the Wright brothers, flight research and testing were the crucible in which aeronautical concepts were advanced and proven to the point that engineers and companies are willing to stake their future to produce and design aircraft. This is still true today, as shown by the development of the experimental X-30 aerospace plane. The Dryden Flight Research Center (Ames-Dryden) continues to be involved in a number of flight research programs that require understanding and characterization of the total airplane in all the aeronautical disciplines, for example the X-29. Other programs such as the F-14 variable-sweep transition flight experiment have focused on a single concept or discipline. Ames-Dryden also continues to conduct flight and ground based experiments to improve and expand the ability to test and evaluate advanced aeronautical concepts. A review of significant aeronautical flight research programs and experiments is presented to illustrate both the progress being made and the challenges to come.

  4. Final work plan: Expedited Site Characterization of the IES Industries, Inc., Site at Marshalltown, Iowa. Ames Expedited Site Characterization Project, Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-04

    The overall goal of the Ames Laboratory Expedited Site Characterization (ESC) project is to evaluate and promote both innovative and state-of-the-practice site characterization and/or monitoring technologies. This will be accomplished by fielding both types of technologies together in the context of an expedited site characterization. The first site will be at a former manufactured gas plant (FMGP) in Marshalltown, Iowa. The project will field three areas of technology: geophysical, analytical, and data fusion. Geophysical technologies are designed to understand the subsurface geology to help predict fate and transport of the target contaminants. Analytical technologies/methods are designed to detect and quantify the target contaminants. Data fusion technology consists of software systems designed to rapidly integrate or fuse all site information into a conceptual site model that then becomes the decision making tool for the site team to plan subsequent sampling activity. Not all of the contaminants present can be located at the action level. Polynuclear aromatic hydrocarbons (PAHs) are the signature organics associated with the coal tar activities that took place at the site. As a result, PAHs were selected as the target compounds. Screening analytical instruments and nonintrusive geophysical techniques will be fielded to qualitatively map the spatial contaminant distribution. Soil gas surveys, immunoassay testing (IMA), innovative optical techniques, and passive organic sorbent sensors will be deployed along with the geophysical methods. Gas chromatography/mass spectrometry (GC/MS) instruments and a cone penetrometer system equipped with a laser-induced fluorescence (LIF) probe will quantitatively map the action level edges of the PAH plume(s). Samples will be taken both by the cone penetrometer test system (CPT) and the Geoprobe {reg_sign} sampler system.

  5. Huellas de las religiones tradicionales del África subsahariana en América Latina y el Caribe

    Directory of Open Access Journals (Sweden)

    Lazaro Cabrera Thompson

    2008-01-01

    Full Text Available El artículo explora las religiones tradicionales practicadas por los pueblos ewe-mina, ewe-fon, bantú y yoruba del África subsahariana, antes de abordar las formas como estas prácticas religiosas persisten en el “Nuevo Mundo” tras la llegada forzosa de aquellos esclavizados africanos. Con base en la presencia de estas religiones tradicionales africanas en distintos países latinoamericanos y caribeño, se evidencia un conjunto religioso fusionado por historias, mitos, leyendas, danza, música, etc. de ascendencia africana y se hace un llamado a los/ as investigadores/as, que desde América Latina y el Caribe, indagan sobre las religiones tradicionales yoruba, para que franqueen los límites de Nigeria con el fin de abarcar a toda la diáspora yoruba.

  6. AMES, NESC and ENIQ: European networks in the field of structural integrity involving NDE and inspection effectiveness assessment

    International Nuclear Information System (INIS)

    Crutzen, S.; Hurst, R.; Debarberis, L.; Lemaitre, P.; Eriksen, B.

    1999-01-01

    Three European networks on structural integrity aspects of ageing nuclear components are presently managed by the Institute for Advanced Materials of the Joint Research Centre of the European Commission: AMES (Ageing Materials Evaluation and Studies), ENIQ (European Network for Inspection Qualification) and NESC (Network for Evaluating Steel Components). All three networks involve actions, which aim at the effectiveness and reliability assessment of NDE techniques and of inspection procedures: Either for materials damage detection and characterisation or for defect detection and evaluation. This paper is describing very generally the objectives of the three networks and is then concentrating on the results obtained in ENIQ, which are relevant with ISI and regulatory issues. (orig./DGE)

  7. Comparative mutability of the Ames tester strains of Salmonella typhimurium by ultraviolet radiation and by 4-nitroquinoline I-oxide

    International Nuclear Information System (INIS)

    Nakano, E.; Ichikawa-Ryo, H.; Kondo, S.

    1982-01-01

    A standard method for determining mutant frequencies per survivor was used to study the detailed kinetics of reverse mutations of Ames tester strains of Salmonella typhimurium induced by UV and by 4NQO. After UV irradiation, strain TA1538 was non-mutable, but its plasmid-containing derivative TA98 was mutable, whereas TA1535 was mutable and its plasmid-bearing derivative TA100 was about 10-fold more mutable. After treatment with 4NQO, TA98 was less mutable than TA1538, whereas TA100 was more mutable than TA1535 by a factor of 10-50. TA1537 was slightly less mutable than TA1535 by either UV or 4NQO. The differential mutabilities of these strains are briefly discussed in relation to the 'hot spot' base sequences for reversion and the nature of DNA damage caused by UV and 4NQO. (orig.)

  8. The effects of alcohol mixed with energy drink (AMED) on subjective intoxication and alertness : results from a double-blind placebo-controlled clinical trial

    NARCIS (Netherlands)

    van de Loo, Aurora J A E; van Andel, Nienke; van Gelder, Charlotte A G H; Janssen, Boris S G; Titulaer, Joep; Jansen, Jimmy; Verster, Joris C

    2016-01-01

    OBJECTIVE: The purpose of this double blind placebo controlled study was to examine if specific effects on subjective intoxication and alertness-sleepiness ratings could be demonstrated after consuming alcohol mixed with energy drink (AMED) when compared to consuming alcohol only (AO). METHODS: 56

  9. Assessing Mutagenicity of Methanolic Exteract of Borage Flower (Echium amuenum Using Ames Bioassay

    Directory of Open Access Journals (Sweden)

    Meysam Moosavi

    2014-08-01

    Full Text Available Background: pyrrolizidine alkaloids have been isolated from Echium amuenum. These alkaloids knowing as hepatotoxic, damage the liver. Mutagenicity of pure pyrrolizidine alkaloids has been identified. Thus, the mutagenic effect of the methanolic flower extract was tested using Amest test. Materials and Methods: The long maceration process (for 48 hrs is carried out in order to extract all constitutes. Thin layer chromatography (TLC method was used to evaluate aflatoxin B1 contamination and histidine amino acid presence. Minimum inhibitory concentration (MIC was determined with the dilution method. Salmonella typhimurium strain TA100 was used to determination of mutagenicity. The genotype was confirmed by using histidine requirement, R- factor presence, rfa and uvrB mutations tests. The mutagenicity assay was performed by four extract concentrations (0.25, 0.5, 0.75 and 1mg/ml. Sodium azide (NaN3 and methanol were used as the mutagens (positive control and negative control, respectively in the absence or presence of liver-metabolizing enzymes. Results: The data indicate that Echium amuenum has not significant mutagenic activity against negative control. The presence of liver-metabolizing enzymes did not exhibit a significant change against the properties of extract. Conclusion: It seems that this extensive used plant in traditional medicine, doesn’t contain mutagenic or genotoxic effect in usual doses.

  10. Desarrollo y productividad de ñame (Dioscorea trifida y Dioscorea esculenta en diferentes condiciones hídricas

    Directory of Open Access Journals (Sweden)

    Alba Nelly Acevedo Mercado

    2015-01-01

    Full Text Available En la región Montes de María (9° 24' 56,33" N y 75° 23' 04,19" O, departamento de Sucre, Colombia, en zonas de clima cálido (26 °C y 30 °C y de clima medio (20 °C y 24 °C, humedad relativa entre 75 y 85% y precipitación de 750 mm durante el ensayo se estudió el efecto del riego en el desarrollo y productividad de dos especies de ñame en peligro de extinción (Dioscorea trifida y Dioscorea esculenta en un diseño experimental de parcelas subdivididas, donde las variables fueron tres condiciones hídricas: riego de 888 mm durante la etapa crítica del cultivo, riego de 944 mm durante todo el ciclo del cultivo, y ausencia de riego con una oferta de agua de 750 mm provenientes de precipitación. La densidad de siembra fue de 10,000 plantas/ha, labranza tradicional con arado de discos y cosecha 8 meses después de la siembra. Como variables se midieron rendimiento de ñame, contenido de almidón, longitud y diámetro de tubérculos y biomasa aérea. Dioscorea trifida presentó un rendimiento promedio de 30.6 t/ha y D. esculenta de 27 t/ha, con contenidos de almidón de 21.3 y 21.6% en base húmeda, respectivamente; la longitud promedio de tubérculos para D. trifida fue de 17.4 cm y para D. esculenta de 11.4 cm; los diámetros promedio fueron 14.4 cm y 10.5 cm y la biomasa aérea 1.1 kg/planta y 0.67 kg/planta, respectivamente. La aplicación de riego al cultivo produjo un incremento en la producción con respecto al cultivo sin riego, para Dioscorea trifida este incremento fue de 78.9% y para Dioscorea esculenta de 92.9%.

  11. Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice.

    Science.gov (United States)

    Brown-Borg, Holly M; Rakoczy, Sharlene

    2013-09-01

    Restrictive dietary interventions exert significant beneficial physiological effects in terms of aging and age-related disease in many species. Every other day feeding (EOD) has been utilized in aging research and shown to mimic many of the positive outcomes consequent with dietary restriction. This study employed long living Ames dwarf mice subjected to EOD feeding to examine the adaptations of the oxidative phosphorylation and antioxidative defense systems to this feeding regimen. Every other day feeding lowered liver glutathione (GSH) concentrations in dwarf and wild type (WT) mice but altered GSH biosynthesis and degradation in WT mice only. The activities of liver OXPHOS enzymes and corresponding proteins declined in WT mice fed EOD while in dwarf animals, the levels were maintained or increased with this feeding regimen. Antioxidative enzymes were differentially affected depending on the tissue, whether proliferative or post-mitotic. Gene expression of components of liver methionine metabolism remained elevated in dwarf mice when compared to WT mice as previously reported however, enzymes responsible for recycling homocysteine to methionine were elevated in both genotypes in response to EOD feeding. The data suggest that the differences in anabolic hormone levels likely affect the sensitivity of long living and control mice to this dietary regimen, with dwarf mice exhibiting fewer responses in comparison to WT mice. These results provide further evidence that dwarf mice may be better protected against metabolic and environmental perturbations which may in turn, contribute to their extended longevity. © 2013.

  12. Measurement of isotopic cross sections of the fission fragments produced in 500 AMeV 208Pb + p reaction

    International Nuclear Information System (INIS)

    Fernandez-Dominguez, B.

    2003-03-01

    The aim of this work is the study of the fission fragments produced in the spallation reaction 208 Pb + p at 500 AMeV. The fission fragments from Z=23 up to Z=59 have been detected and identified by using the inverse kinematics technique with the high-resolution spectrometer FRS. The production cross sections and the recoil velocities of 430 nuclei have been measured. The measured data have been compared with previous data. The isotopic distributions show a high precision. However, the absolute value of the fission cross section is higher than expected. From the experimental data the characteristics of the average fissioning system have been reconstructed (Z fis , A fis , E* fis ). In addition, the number of post-fission neutrons emitted from the fission fragments, v post , has been determined by using a new method. The experimental data have been compared to the two-steps models describing the spallation reaction. The impact of the model parameters on the observables has been analysed and the reasons Leading to the observed differences between the codes are also presented. This analyse shows a good agreement with the INCL4+ABLA code. (author)

  13. Prevalência de práticas educativas acerca do aleitamento materno exclusivo (AME em Cuiabá - MT

    Directory of Open Access Journals (Sweden)

    Luma Natalia Barbosa

    2015-03-01

    Full Text Available Objetivo: Descrever a prevalência das práticas educativas em saúde sobre o aleitamento materno exclusivo (AME no Município de Cuiabá - MT nos meses de julho a dezembro de 2012. Métodos: Trata-se de um estudo descritivo transversal, realizado junto a mulheres internadas em um hospital. A amostra foi composta por 306 mulheres no período pós-parto imediato. Os dados foram coletados por meio de um questionário semiestruturado. Resultados: Ter oito anos ou mais de estudo (RP = 1,77; ter renda até dois salários mínimos (RP = 1,22; ter planejado a gravidez (RP = 1,31; ter iniciado o atendimento no serviço de pré-natal no primeiro trimestre (RP = 1,65 e serem primíparas (RP = 1,21 são características que aparecem associadas com uma maior chance de receber orientações sobre aleitamento materno do que as demais mulheres. Conclusão: Faz-se necessário repensar mudanças dessas práticas, a fim de se realizar ações educativas que busquem efetivar transformações na relação profissional/usuário, visando o acolhimento das gestantes.

  14. Report of the Interagency Optical Network Testbeds Workshop 2, NASA Ames Research Center, September 12-14, 2005

    Science.gov (United States)

    2005-01-01

    The Optical Network Testbeds Workshop 2 (ONT2), held on September 12-14, 2005, was cosponsored by the Department of Energy Office of Science (DOE/SC) and the National Aeronautics and Space Administration (NASA), in cooperation with the Joint Engineering Team (JET) of the Federal Networking and Information Technology Research and Development (NITRD) Program's Large Scale Networking (LSN) Coordinating Group. The ONT2 workshop was a follow-on to an August 2004 Workshop on Optical Network Testbeds (ONT1). ONT1 recommended actions by the Federal agencies to assure timely development and implementation of optical networking technologies and infrastructure. Hosted by the NASA Ames Research Center in Mountain View, California, the ONT2 workshop brought together representatives of the U.S. advanced research and education (R&E) networks, regional optical networks (RONs), service providers, international networking organizations, and senior engineering and R&D managers from Federal agencies and national research laboratories. Its purpose was to develop a common vision of the optical network technologies, services, infrastructure, and organizations needed to enable widespread use of optical networks; recommend activities for transitioning the optical networking research community and its current infrastructure to leading-edge optical networks over the next three to five years; and present information enabling commercial network infrastructure providers to plan for and use leading-edge optical network services in that time frame.

  15. Environmental Assessment for US Department of Energy support of an Iowa State University Linear Accelerator Facility at Ames, Iowa

    Energy Technology Data Exchange (ETDEWEB)

    1990-05-01

    The proposed Department of Energy (DOE) action is financial and technical support of construction and initial operation of an agricultural commodity irradiator (principally for meat), employing a dual mode electron beam generator capable of producing x-rays, at the Iowa State University Linear Accelerator located at Ames, Iowa. The planned pilot commercial-scale facility would be used for the following activities: conducting irradiation research on agricultural commodities, principally meats; in the future, after the pilot phase, as schedules permit, possibly conducting research on other, non-edible materials; evaluating effects of irradiation on nutritional and sensory quality of agricultural products; demonstrating the efficiency of the process to control or eliminate pathogens, and/or to prolong the commodities' post-harvest shelf-life via control or elimination of bacteria, fungi, and/or insects; providing information to the public on the benefits, safety and risks of irradiated agricultural commodities; determining consumer acceptability of the irradiated products; providing data for use by regulatory agencies in developing protocols for various treatments of Iowa agricultural commodities; and training operators, maintenance and quality control technicians, scientists, engineers, and staff of regulatory agencies in agricultural commodity irradiation technology. 14 refs., 5 figs.

  16. Evaluation of Different Methods for Identification of Structural Alerts Using Chemical Ames Mutagenicity Data Set as a Benchmark.

    Science.gov (United States)

    Yang, Hongbin; Li, Jie; Wu, Zengrui; Li, Weihua; Liu, Guixia; Tang, Yun

    2017-06-19

    Identification of structural alerts for toxicity is useful in drug discovery and other fields such as environmental protection. With structural alerts, researchers can quickly identify potential toxic compounds and learn how to modify them. Hence, it is important to determine structural alerts from a large number of compounds quickly and accurately. There are already many methods reported for identification of structural alerts. However, how to evaluate those methods is a problem. In this paper, we tried to evaluate four of the methods for monosubstructure identification with three indices including accuracy rate, coverage rate, and information gain to compare their advantages and disadvantages. The Kazius' Ames mutagenicity data set was used as the benchmark, and the four methods were MoSS (graph-based), SARpy (fragment-based), and two fingerprint-based methods including Bioalerts and the fingerprint (FP) method we previously used. The results showed that Bioalerts and FP could detect key substructures with high accuracy and coverage rates because they allowed unclosed rings and wildcard atom or bond types. However, they also resulted in redundancy so that their predictive performance was not as good as that of SARpy. SARpy was competitive in predictive performance in both training set and external validation set. These results might be helpful for users to select appropriate methods and further development of methods for identification of structural alerts.

  17. Exploring reaction mechanisms and their competition in 58Ni+48Ca collisions at E = 25 AMeV

    Directory of Open Access Journals (Sweden)

    Francalanza L.

    2014-03-01

    Full Text Available Latest results concerning the study of central collisions in 58Ni+48Ca reactions at Elab(Ni=25 AMeV are presented. The experimental data, collected with the CHIMERA 4π device, have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain. The method adopted to perform the centrality selection refers to the global variable “flow angle”, that is related to the event shape in momentum space, as it is determined by the eigenvectors of the experimental kinetic-energy tensor. The main features of the reaction products were explored by using different constraints on some of the relevant observables, such as mass and velocity distributions and their correlations. Much emphasis was devoted to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a prompt multifragmentation mechanism. The reaction mechanism was simulated in the framework of transport theories (dynamical stochastic BNV calculations, followed by sequential SIMON code and further comparison with dynamical calculations from transport model (QMD, CoMD are in progress. Moreover, an extension of this study taking into account for the light particles has been envisaged.

  18. Communication skills: an essential component of medical curricula. Part I: Assessment of clinical communication: AMEE Guide No. 51.

    Science.gov (United States)

    Laidlaw, Anita; Hart, Jo

    2011-01-01

    This AMEE Guide in Medical Education is Part 1 of a two part Guide covering the issues of Communication. This Guide has been written to provide guidance for those involved in planning the assessment of clinical communication and provides guidance and information relating to the assessment of various aspects of clinical communication; its underlying theory; its practical ability to show that an individual is competent and its relationship to students' daily performance. The advantages and disadvantages of assessing specific aspects of communication are also discussed. The Guide draws attention to the complexity of assessing the ability to communicate with patients and healthcare professionals, with issues of reliability and validity being highlighted for each aspect. Current debates within the area of clinical communication teaching are raised: when should the assessment of clinical communication occur in undergraduate medical education?; should clinical communication assessment be integrated with clinical skills assessment, or should the two be separate?; how important should the assessment of clinical communication be, and the question of possible failure of students if they are judged not competent in communication skills? It is the aim of the authors not only to provide a useful reference for those starting to develop their assessment processes, but also provide an opportunity for review and debate amongst those who already assess clinical communication within their curricula, and a resource for those who have a general interest in medical education who wish to learn more about communication skills assessment.

  19. Analysis of (3He, t) charge exchange reactions at 140 AMeV

    International Nuclear Information System (INIS)

    Singh, Pardeep; Zegers, R.G.T.; Danielewicz, Pawel; Noji, S.; Kim, B.T.; Sakai, H.

    2014-01-01

    The spin-isospin response in nuclei has been studied widely through ( 3 He, t) and (t, 3 He) charge-exchange reactions wherein a proton (neutron) transforms into a neutron (proton), which in turn changes the isospin, ΔT=1, of the nuclei participating in the reaction, either with or without spin transfer. The Gamow-Teller transitions are used to obtain the weak transition strength in the excitation-energy regions inaccessible through β-decay. The strengths deduced using charge exchange experiments provide stringent tests for nuclear structure calculations and serve as inputs for variety of applications in which weak transition strengths play a role. In this context, we explore here the ( 3 He,t) charge-exchange reaction at 140 MeV/u on 18 O, 26 Mg, 58,60,62, 64 Ni, 90 Zr, 118,120 Sn and 208 Pb targets, within the theoretical framework of distorted wave impulse approximation

  20. Retrospective of photography at NASA Ames Research Center from 1940 to 1996 (Extended Abstract)

    Science.gov (United States)

    Ponseggi, Bernard G.

    1997-05-01

    This paper deals with what is known as photo/optical instrumentation technology and/or technical photography. In 1940 this was called photography, in the late 40's the Civil Service Commission introduced a new classification called photography/technical to differentiate between still photographers and those engaging in recording engineering data. In October of 1958 a historic event took place, Congress transferred all of the duties of NACA to a newly formed agency called NASA, and with it came a call for systems that would keep up with new requirements. There was a need to change the type and style of equipment to keep up with the demands for more accurate information. Existing hardware was modified and new hardware was developed and designed to meet the new requirements of space travel of manned and unmanned orbital vehicles. This family of equipment had to withstand the rigors of space travel such as extremely high `G' forces, temperature changes and `O' gravity, while on earth we needed equipment to document launch of space vehicles as well as wind tunnel testing, rocket sled stands etc.. Some requirements were similar to those of launch vehicles, some were totally different and had other requirements, eventually they were all resolved. As electronic data systems became available NASA experimented with their use in data acquisition. This portion of this session will discuss the changes over the years and their effect on the acquisition of data, those that worked, as well as those that were a disappointment.

  1. Testing Testing Testing.

    Science.gov (United States)

    Deville, Craig; O'Neill, Thomas; Wright, Benjamin D.; Woodcock, Richard W.; Munoz-Sandoval, Ana; Gershon, Richard C.; Bergstrom, Betty

    1998-01-01

    Articles in this special section consider (1) flow in test taking (Craig Deville); (2) testwiseness (Thomas O'Neill); (3) test length (Benjamin Wright); (4) cross-language test equating (Richard W. Woodcock and Ana Munoz-Sandoval); (5) computer-assisted testing and testwiseness (Richard Gershon and Betty Bergstrom); and (6) Web-enhanced testing…

  2. Cognitive Load Theory: implications for medical education: AMEE Guide No. 86.

    Science.gov (United States)

    Young, John Q; Van Merrienboer, Jeroen; Durning, Steve; Ten Cate, Olle

    2014-05-01

    Cognitive Load Theory (CLT) builds upon established models of human memory that include the subsystems of sensory, working and long-term memory. Working memory (WM) can only process a limited number of information elements at any given time. This constraint creates a "bottleneck" for learning. CLT identifies three types of cognitive load that impact WM: intrinsic load (associated with performing essential aspects of the task), extraneous load (associated with non-essential aspects of the task) and germane load (associated with the deliberate use of cognitive strategies that facilitate learning). When the cognitive load associated with a task exceeds the learner's WM capacity, performance and learning is impaired. To facilitate learning, CLT researchers have developed instructional techniques that decrease extraneous load (e.g. worked examples), titrate intrinsic load to the developmental stage of the learner (e.g. simplify task without decontextualizing) and ensure that unused WM capacity is dedicated to germane load, i.e. cognitive learning strategies. A number of instructional techniques have been empirically tested. As learners' progress, curricula must also attend to the expertise-reversal effect. Instructional techniques that facilitate learning among early learners may not help and may even interfere with learning among more advanced learners. CLT has particular relevance to medical education because many of the professional activities to be learned require the simultaneous integration of multiple and varied sets of knowledge, skills and behaviors at a specific time and place. These activities possess high "element interactivity" and therefore impose a cognitive load that may surpass the WM capacity of the learner. Applications to various medical education settings (classroom, workplace and self-directed learning) are explored.

  3. Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction.

    Directory of Open Access Journals (Sweden)

    Oge Arum

    Full Text Available Ames dwarf (Prop1 (df/df mice are remarkably long-lived and exhibit many characteristics of delayed aging and extended healthspan. Caloric restriction (CR has similar effects on healthspan and lifespan, and causes an extension of longevity in Ames dwarf mice. Our study objective was to determine whether Ames dwarfism or CR influence neuromusculoskeletal function in middle-aged (82 ± 12 weeks old or old (128 ± 14 w.o. mice. At the examined ages, strength was improved by dwarfism, CR, and dwarfism plus CR in male mice; balance/ motor coordination was improved by CR in old animals and in middle-aged females; and agility/ motor coordination was improved by a combination of dwarfism and CR in both genders of middle-aged mice and in old females. Therefore, extension of longevity by congenital hypopituitarism is associated with improved maintenance of the examined measures of strength, agility, and motor coordination, key elements of frailty during human aging, into advanced age. This study serves as a particularly important example of knowledge related to addressing aging-associated diseases and disorders that results from studies in long-lived mammals.

  4. Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction.

    Science.gov (United States)

    Arum, Oge; Rasche, Zachary Andrew; Rickman, Dustin John; Bartke, Andrzej

    2013-01-01

    Ames dwarf (Prop1 (df/df) ) mice are remarkably long-lived and exhibit many characteristics of delayed aging and extended healthspan. Caloric restriction (CR) has similar effects on healthspan and lifespan, and causes an extension of longevity in Ames dwarf mice. Our study objective was to determine whether Ames dwarfism or CR influence neuromusculoskeletal function in middle-aged (82 ± 12 weeks old) or old (128 ± 14 w.o.) mice. At the examined ages, strength was improved by dwarfism, CR, and dwarfism plus CR in male mice; balance/ motor coordination was improved by CR in old animals and in middle-aged females; and agility/ motor coordination was improved by a combination of dwarfism and CR in both genders of middle-aged mice and in old females. Therefore, extension of longevity by congenital hypopituitarism is associated with improved maintenance of the examined measures of strength, agility, and motor coordination, key elements of frailty during human aging, into advanced age. This study serves as a particularly important example of knowledge related to addressing aging-associated diseases and disorders that results from studies in long-lived mammals.

  5. THE NASA AMES PAH IR SPECTROSCOPIC DATABASE VERSION 2.00: UPDATED CONTENT, WEB SITE, AND ON(OFF)LINE TOOLS

    Energy Technology Data Exchange (ETDEWEB)

    Boersma, C.; Mattioda, A. L.; Allamandola, L. J. [NASA Ames Research Center, MS 245-6, Moffett Field, CA 94035 (United States); Bauschlicher, C. W. Jr.; Ricca, A. [NASA Ames Research Center, MS 230-3, Moffett Field, CA 94035 (United States); Cami, J.; Peeters, E.; De Armas, F. Sánchez; Saborido, G. Puerta [SETI Institute, 189 Bernardo Avenue 100, Mountain View, CA 94043 (United States); Hudgins, D. M., E-mail: Christiaan.Boersma@nasa.gov [NASA Headquarters, MS 3Y28, 300 E St. SW, Washington, DC 20546 (United States)

    2014-03-01

    A significantly updated version of the NASA Ames PAH IR Spectroscopic Database, the first major revision since its release in 2010, is presented. The current version, version 2.00, contains 700 computational and 75 experimental spectra compared, respectively, with 583 and 60 in the initial release. The spectra span the 2.5-4000 μm (4000-2.5 cm{sup -1}) range. New tools are available on the site that allow one to analyze spectra in the database and compare them with imported astronomical spectra as well as a suite of IDL object classes (a collection of programs utilizing IDL's object-oriented programming capabilities) that permit offline analysis called the AmesPAHdbIDLSuite. Most noteworthy among the additions are the extension of the computational spectroscopic database to include a number of significantly larger polycyclic aromatic hydrocarbons (PAHs), the ability to visualize the molecular atomic motions corresponding to each vibrational mode, and a new tool that allows one to perform a non-negative least-squares fit of an imported astronomical spectrum with PAH spectra in the computational database. Finally, a methodology is described in the Appendix, and implemented using the AmesPAHdbIDLSuite, that allows the user to enforce charge balance during the fitting procedure.

  6. Ames dwarf (Prop1(df)/Prop1(df)) mice display increased sensitivity of the major GH-signaling pathways in liver and skeletal muscle.

    Science.gov (United States)

    Miquet, Johanna G; Muñoz, Marina C; Giani, Jorge F; González, Lorena; Dominici, Fernando P; Bartke, Andrzej; Turyn, Daniel; Sotelo, Ana I

    2010-04-01

    Growth hormone (GH) is an anabolic hormone that regulates growth and metabolism. Ames dwarf mice are natural mutants for Prop1, with impaired development of anterior pituitary and undetectable levels of circulating GH, prolactin and TSH. They constitute an endocrine model of life-long GH-deficiency. The main signaling cascades activated by GH binding to its receptor are the JAK2/STATs, PI-3K/Akt and the MAPK Erk1/2 pathways. We have previously reported that GH-induced STAT5 activation was higher in Ames dwarf mice liver compared to non-dwarf controls. The aim of this study was to evaluate the principal components of the main GH-signaling pathways under GH-deficiency in liver and skeletal muscle, another GH-target tissue. Ames dwarf mice and their non-dwarf siblings were assessed. Animals were injected i.p. with GH or saline 15min before tissue removal. Protein content and phosphorylation of signaling mediators were determined by immunoblotting of tissue solubilizates. GH was able to induce STAT5 and STAT3 tyrosine phosphorylation in both liver and muscle, but the response was higher for Ames dwarf mice than for non-dwarf controls. When Erk1/2 activation was assessed in liver, only dwarf mice showed GH-induced phosphorylation, while in muscle no response to the hormone was found in either genotype. GH-induced Akt phosphorylation at Ser473 in liver was only detected in dwarf mice. In skeletal muscle, both normal and dwarf mice responded to a GH stimulus, although dwarf mice presented higher GH activation levels. The phosphorylation of GSK-3, a substrate of Akt, increased upon hormone stimulation only in dwarf mice in both tissues. In contrast, no differences in the phosphorylation of mTOR, another substrate of Akt, were observed after GH stimulus, either in normal or dwarf mice in liver, while we were unable to determine mTOR in muscle. Protein content of GH-receptor and of the signaling mediators studied did not vary between normal and dwarf animals in the assessed

  7. Ciencéame

    OpenAIRE

    Rivera Castaño, José Juan

    2014-01-01

    En la actualidad las redes sociales son el medio de comunicación más utilizado dentro del mundo que rodea a Internet, ya que aporta a la sociedad un canal de interacción amplio y fluido, el cual se construye a través de un intercambio de información entre grupos de personas, instituciones, entidades y organizaciones. La importancia de la comunicación en la red ha sido tal, que la industria del software ha realizado grandes esfuerzos para pasar de sitios webs como los blogs dond...

  8. Reflections About the Role of Intellectuals in Latin America Reflexiones acerca del rol de los intelectuales en América Latina Reflexões sobre o papel dos intelectuais na América Latina

    Directory of Open Access Journals (Sweden)

    Judith Naidorf

    2010-10-01

    intellectual debate but to contribute to a not new but always applicable, which should be a breakthrough for each of our practices in the different social areas in which we daily work.

    En este trabajo nos proponemos abordar algunos aspectos teórico - conceptuales que contribuyan a la reflexión sobre la especificidad del papel del intelectual latinoamericano actual. Los aportes de diversos autores nos ayudarán a caracterizar un rol que se encuentra en permanente reformulación, análisis y discusión. La propuesta es retomar los desarrollos teóricos de la categoría de intelectual, desde Antonio Gramsci e Immanuel Wallerstein principalmente, pasando por sus momentos más intensos en la década del 60-70 con Sartre y Foucault en Europa. También se rescatan las contribuciones realizadas por Pierre Bourdieu, Sousa Santos y los aportes para América Latina de Fals Borda, Florestán Fernández, Octavio Ianni y Eliseo Verón, entre otros. Además se incluyen como ejemplos declaraciones del subcomandante Marcos para el EZLN y se hace referencia a los análisis realizados por Julio Gambina y Daniel Campione para el caso argentino. No es interés de este trabajo arribar a definiciones acabadas acerca de la función social del intelectual sino aportar a un debate no nuevo pero siempre vigente. Neste trabalho pretendemos abordar alguns aspectos teóricos-conceituais que contribuem para a reflexão sobre especificidade do papel do intelectual latino-americano atual. As contribuições de diferentes autores nos ajudam a caracterizar um papel que está constantemente sendo repensado, a análisado e discutido. A proposta é revisitar aos desenvolvimentos teóricos sobre o "intelectual" de Antonio Gramsci e Emanuel Wallerstein principalmente através dos debates mais intensos na década de 60-70 com Sartre e Foucault na Europa. Também se destacam as contribuições feitas por Pierre Bourdieu, Sousa Santos e contribuições desde América Latina de

  9. Respuesta fisiológica del ñame espino (Dioscorea Rotundata Poir a las densidades de siembra

    Directory of Open Access Journals (Sweden)

    Dairo J. Pérez

    2015-12-01

    Full Text Available Esta investigación tuvo como objetivo estudiar la respuesta fisiológica del ñame espino (Dioscorea rotundata cv. brasilero en función del incremento de las densidades de siembra, bajo la oferta ambiental del Sinú medio. El estudio se llevó a cabo en la Universidad de Córdoba (Montería, Colombia, donde se evaluaron las densidades de siembra de 45.455, 30.303, 22.727 y 10.101 plantas/ha; bajo un diseño de Bloques Completos al Azar con tres repeticiones. Las variables de respuestas consideradas fueron la fotosíntesis neta (Pn, medida en tres etapas fenológicas (vegetativa, inicio y final de tuberización; y los índices de crecimiento: tasa absoluta de crecimiento (TAC, tasa de asimilación neta (TAN, tasa relativa de crecimiento (TRC e índice de área foliar (IAF. La Pn no varió entre las densidades de siembra (p≤0,05, pero después de la etapa vegetativa, se redujo en promedio un 19,14% para el inicio y final de la tuberización. La TAC y la TRC tuvieron similar tendencia, se incrementaron desde la etapa vegetativa, pero esta última se redujo al final del cultivo. La TAN comenzó a decrecer desde la etapa vegetativa con un leve incremento al final del ciclo. El IAF se incrementó significativamente a partir de la tuberización, para las densidades de siembra superiores a 10.101 plantas/ha, alcanzando valores entre 3,08 y 4,03. Se concluye que los índices de crecimiento a excepción del IAF y la Pn, no variaron entre las densidades de siembra, probablemente por la capacidad de la especie de regular su actividad fisiológica en función de la densidad de siembra.

  10. Effect of Methyl tert-Butyl Ether in Standard Tests for Mutagenicity and Environmental Toxicity

    Czech Academy of Sciences Publication Activity Database

    Vosáhlíková, M.; Cajthaml, Tomáš; Demnerová, K.; Pazlarová, Jarmila

    2006-01-01

    Roč. 21, č. 6 (2006), s. 599-605 ISSN 1520-4081 Institutional research plan: CEZ:AV0Z50200510 Keywords : toxicity * mtbe * ames test Subject RIV: EE - Microbiology, Virology Impact factor: 1.582, year: 2006

  11. 9 CFR 147.7 - Standard test procedures for mycoplasma. 5

    Science.gov (United States)

    2010-01-01

    ... depend on preference, laboratory facilities, and availability of antigen. These three tests, though quite... titered sera are available from the National Veterinary Services Laboratories (NVSL), P.O. Box 884, Ames... blood to 5 parts Alsever's solution (e.g., 8 ml blood in 40 ml of Alsever's solution). Centrifuge the...

  12. NATO Allied Medical Publication 7.5 (AMedP 7.5) NATO Planning Guide for the Estimation of CBRN Casualties

    Science.gov (United States)

    2016-12-01

    PROMULGATION [ Date ] 1. The enclosed Allied Medical Publication AMedP-7.5, NATO Planning Guide for the Estimation of CBRN Casualties, which has been... radioisotopes modeled are 60Co, 90Sr, 99Mo, 125I, 131I, 137Cs, 192Ir, 226Ra, 238Pu, 241Am, 252Cf. 2) Whole-body irradiation (from cloudshine, groundshine,9... Earth Shelter 16.67 66.67 Exposed/Dismounted 1.00 1.00 Foxhole (nuclear only)† 3.00 10.00 Masonry Building 8.33 6.67 Multi-Story Brick Building 1.33

  13. A New Way of Doing Business: Reusable Launch Vehicle Advanced Thermal Protection Systems Technology Development: NASA Ames and Rockwell International Partnership

    Science.gov (United States)

    Carroll, Carol W.; Fleming, Mary; Hogenson, Pete; Green, Michael J.; Rasky, Daniel J. (Technical Monitor)

    1995-01-01

    NASA Ames Research Center and Rockwell International are partners in a Cooperative Agreement (CA) for the development of Thermal Protection Systems (TPS) for the Reusable Launch Vehicle (RLV) Technology Program. This Cooperative Agreement is a 30 month effort focused on transferring NASA innovations to Rockwell and working as partners to advance the state-of-the-art in several TPS areas. The use of a Cooperative Agreement is a new way of doing business for NASA and Industry which eliminates the traditional customer/contractor relationship and replaces it with a NASA/Industry partnership.

  14. Multiplicación in vitro de segmentos nodales del clon de ñame Blanco de Guinea (Dioscorea cayenensis - D. rotundata ) en sistemas de cultivo semiautomatizado

    OpenAIRE

    Manuel Cabrera Jova; Rafael Gómez Kosky; Sergio Rodríguez Morales; Jorge López Torres; Aymé Rayas Cabrera; Milagros Basail Pérez; Arletys Santos Pino; Víctor Medero Vega; Germán Rodríguez Rodríguez

    2009-01-01

    Con el empleo del sistema de inmersión temporal fue posible incrementar la multiplicación in vitro de los segmentos nodales en el clon de ñame Blanco de Guinea. Con este tipo de sistema de cultivo se obtuvieron los más altos valores para la altura de la planta, número de entrenudos por planta, así como para la masa fresca y seca de las mismas. Las condiciones de cultivo creadas en el sistema de inmersión temporal para la multiplicación in vitro de los segmentos nodales lograron el más alto co...

  15. When is a search not a search? A comparison of searching the AMED complementary health database via EBSCOhost, OVID and DIALOG.

    Science.gov (United States)

    Younger, Paula; Boddy, Kate

    2009-06-01

    The researchers involved in this study work at Exeter Health library and at the Complementary Medicine Unit, Peninsula School of Medicine and Dentistry (PCMD). Within this collaborative environment it is possible to access the electronic resources of three institutions. This includes access to AMED and other databases using different interfaces. The aim of this study was to investigate whether searching different interfaces to the AMED allied health and complementary medicine database produced the same results when using identical search terms. The following Internet-based AMED interfaces were searched: DIALOG DataStar; EBSCOhost and OVID SP_UI01.00.02. Search results from all three databases were saved in an endnote database to facilitate analysis. A checklist was also compiled comparing interface features. In our initial search, DIALOG returned 29 hits, OVID 14 and Ebsco 8. If we assume that DIALOG returned 100% of potential hits, OVID initially returned only 48% of hits and EBSCOhost only 28%. In our search, a researcher using the Ebsco interface to carry out a simple search on AMED would miss over 70% of possible search hits. Subsequent EBSCOhost searches on different subjects failed to find between 21 and 86% of the hits retrieved using the same keywords via DIALOG DataStar. In two cases, the simple EBSCOhost search failed to find any of the results found via DIALOG DataStar. Depending on the interface, the number of hits retrieved from the same database with the same simple search can vary dramatically. Some simple searches fail to retrieve a substantial percentage of citations. This may result in an uninformed literature review, research funding application or treatment intervention. In addition to ensuring that keywords, spelling and medical subject headings (MeSH) accurately reflect the nature of the search, database users should include wildcards and truncation and adapt their search strategy substantially to retrieve the maximum number of appropriate

  16. Report of the Interagency Optical Network Testbeds Workshop 2 September 12-14, 2006 NASA Ames Research Center

    Energy Technology Data Exchange (ETDEWEB)

    Joe Mambretti Richard desJardins

    2006-05-01

    A new generation of optical networking services and technologies is rapidly changing the world of communications. National and international networks are implementing optical services to supplement traditional packet routed services. On September 12-14, 2005, the Optical Network Testbeds Workshop 2 (ONT2), an invitation-only forum hosted by the NASA Research and Engineering Network (NREN) and co-sponsored by the Department of Energy (DOE), was held at NASA Ames Research Center in Mountain View, California. The aim of ONT2 was to help the Federal Large Scale Networking Coordination Group (LSN) and its Joint Engineering Team (JET) to coordinate testbed and network roadmaps describing agency and partner organization views and activities for moving toward next generation communication services based on leading edge optical networks in the 3-5 year time frame. ONT2 was conceived and organized as a sequel to the first Optical Network Testbeds Workshop (ONT1, August 2004, www.nren.nasa.gov/workshop7). ONT1 resulted in a series of recommendations to LSN. ONT2 was designed to move beyond recommendations to agree on a series of “actionable objectives” that would proactively help federal and partner optical network testbeds and advanced research and education (R&E) networks to begin incorporating technologies and services representing the next generation of advanced optical networks in the next 1-3 years. Participants in ONT2 included representatives from innovative prototype networks (Panel A), basic optical network research testbeds (Panel B), and production R&D networks (Panels C and D), including “JETnets,” selected regional optical networks (RONs), international R&D networks, commercial network technology and service providers (Panel F), and senior engineering and R&D managers from LSN agencies and partner organizations. The overall goal of ONT2 was to identify and coordinate short and medium term activities and milestones for researching, developing, identifying

  17. Isospin influence on the decay modes of compound systems produced in the 78,86Kr + 40,48Ca at 10 AMeV

    Directory of Open Access Journals (Sweden)

    Pirrone S.

    2016-01-01

    Full Text Available The study of the decay modes competition of the compound systems produced in the collisions 78Kr+40Ca and 86Kr+48Ca at 10AMeV is presented. In particular, the N/Z entrance channel influence on the decay paths of the compound systems, directly connected to the isospin influence, is investigated. The experiment was performed at the INFN Laboratori Nazionali del Sud (LNS in Catania by using the 4π multi-detector CHIMERA. Charge, mass, angular distributions and kinematical features of the reaction products were studied. The analysis shows some differences in the contribution arising from the various reaction mechanisms for the neutron poor and neutron rich systems. Comparison with theoretical statistical and dynamical models are presented for the two systems. Besides a study of the influence of the energy on the entrance channel is performed for the 78Kr+40Ca reaction, by comparing the results of this experiment to those obtained for the same system at 5.5 AMeV with the INDRA device at GANIL.

  18. Thermo Physics Facilities Branch Brochure ARC Jet Complex Fact Sheets, Hypervelocity Free-Flight Aerodynamic Facility Fact Sheets, Ames Vertical Gun Range Fact Sheets

    Science.gov (United States)

    Fretter, E. F. (Editor); Kuhns, Jay (Editor); Nuez, Jay (Editor)

    2003-01-01

    The Ames Arc Jet Complex has a rich heritage of over 40 years in Thermal Protection System (TPS) development for every NASA Space Transportation and Planetary program, including Apollo, Space Shuttle, Viking, Pioneer-Venus, Galileo, Mars Pathfinder,Stardust, NASP,X-33,X-34,SHARP-B1 and B2,X-37 and Mars Exploration Rovers. With this early TPS history came a long heritage in the development of the arc jet facilities. These are used to simulate the aerodynamic heating that occurs on the nose cap, wing leading edges and on other areas of the spacecraft requiring thermal protection. TPS samples have been run in the arc jets from a few minutes to over an hour,from one exposure to multiple exposures of the same sample, in order t o understand the TPS materials response to a hot gas flow environment (representative of real hyperthermal environments experienced in flight). The Ames Arc l e t Complex is a key enabler for customers involved in the three major areas of TPS development: selection, validation, and qualification. The arc jet data are critical for validating TPS thermal models, heat shield designs and repairs, and ultimately for flight qualification.

  19. Application of satellite data to the studies of agricultural meteorology: Relationship between ground temperature from GMS IR data and AMeDAS air temperature

    International Nuclear Information System (INIS)

    Tani, H.; Horiguchi, I.; Motoki, T.

    1984-01-01

    The purpose of the present study is to estimate air temperature in areas where there is no meteorological observation site, using satellite thermal IR data. Surface temperature from GMS IR data derived by eq. (1) was compared with AMeDAS (meteorological observation site) air temperature. The results are summarized as follows: 1) The maximum correlation coefficients between AMeDAS air temperature and surface temperature from GMS IR data is 0.90, the minimum is 0.30 and the mean is 0.60±0.15. 2) The correlation coefficients are affected by the precipitable water and decrease with increasing precipitable Water as shown in Fig. 2. 3) The correlation coefficients for each GMS observed time are better at night and in the morning than during the day (Table 2). 4) Also, the small values of the regression coefficients appear during the day and the large values at night and in the morning (Table 2). 5) The standard deviations which indicated scattering around the regression line are large at 12:00 and 15:00, but small at 06:00 and 09:00 (Table 2). The reason that correlation coefficients, regression coefficients and standard deviations between AMeDAS air temperature and surface temperature from GMS IR data are less during the day than at night and in the morning, is caused by ground conditions because the effects of solar radiation on surface temperature depend on ground surface conditions: plant cover, incline of slope etc. The hourly mean deviation from the regression line for surface temperature was calculated to investigate the characteristic of ground surface conditions for each AMeDAS observation site. AMeDAS observation sites were classified into four types according to the patterns of the hourly mean deviation as shown in Fig. 5. Most of type I were distributed in the plain regions: Ishikari, Konsen and Tokachi. Type II appears in the basin regions and type III on the coast of the Pacific Ocean and the Sea of Okhotsuk. The remaining areas are type IV. The standard

  20. Assessing UAS Flight Testing and It's Importance for Beyond-Line-of-Sight UAS Control in Cooperation with Partnering Organizations

    Science.gov (United States)

    de Jong, Daphne

    2015-01-01

    From the 1st of June until the 21st of August, the internship has been conducted at NASA Ames Research Center as part of the Master of Space Studies at the International Space University. The main activities consisted of doing research on UAV flight-­-testing and the assessing of safety with respect to Beyond-­-Line-­-Of-­-Sight operations. Further activities consisted of accommodating international partners and potential partners at the NASA Ames site, in order to identify mutual interest and future collaboration. Besides those activities, the report describes the planning process of the ISU Space Coast Trip to 10 different space related companies on the west-­-coast of California. Key words: UAS, UAV, BLOS, Ames, ISU Trip

  1. The Center-TRACON Automation System: Simulation and field testing

    Science.gov (United States)

    Denery, Dallas G.; Erzberger, Heinz

    1995-01-01

    A new concept for air traffic management in the terminal area, implemented as the Center-TRACON Automation System, has been under development at NASA Ames in a cooperative program with the FAA since 1991. The development has been strongly influenced by concurrent simulation and field site evaluations. The role of simulation and field activities in the development process will be discussed. Results of recent simulation and field tests will be presented.

  2. Revalidation of the NASA Ames 11-by 11-Foot Transonic Wind Tunnel with a Commercial Airplane Model

    Science.gov (United States)

    Kmak, Frank J.; Hudgins, M.; Hergert, D.; George, Michael W. (Technical Monitor)

    2001-01-01

    The 11-By 11-Foot Transonic leg of the Unitary Plan Wind Tunnel (UPWT) was modernized to improve tunnel performance, capability, productivity, and reliability. Wind tunnel tests to demonstrate the readiness of the tunnel for a return to production operations included an Integrated Systems Test (IST), calibration tests, and airplane validation tests. One of the two validation tests was a 0.037-scale Boeing 777 model that was previously tested in the 11-By 11-Foot tunnel in 1991. The objective of the validation tests was to compare pre-modernization and post-modernization results from the same airplane model in order to substantiate the operational readiness of the facility. Evaluation of within-test, test-to-test, and tunnel-to-tunnel data repeatability were made to study the effects of the tunnel modifications. Tunnel productivity was also evaluated to determine the readiness of the facility for production operations. The operation of the facility, including model installation, tunnel operations, and the performance of tunnel systems, was observed and facility deficiency findings generated. The data repeatability studies and tunnel-to-tunnel comparisons demonstrated outstanding data repeatability and a high overall level of data quality. Despite some operational and facility problems, the validation test was successful in demonstrating the readiness of the facility to perform production airplane wind tunnel%, tests.

  3. Comparative Evaluation of Biochemical Changes in Tomato (Lycopersicon esculentum Mill.) Infected by Alternaria alternata and Its Toxic Metabolites (TeA, AOH, and AME).

    Science.gov (United States)

    Meena, Mukesh; Zehra, Andleeb; Dubey, Manish K; Aamir, Mohd; Gupta, Vijai K; Upadhyay, Ram S

    2016-01-01

    In the present study, we have evaluated the comparative biochemical defense response generated against Alternaria alternata and its purified toxins viz. alternariol (AOH), alternariol monomethyl ether (AME), and tenuazonic acid (TeA). The necrotic lesions developed due to treatment with toxins were almost similar as those produced by the pathogen, indicating the crucial role of these toxins in plant pathogenesis. An oxidative burst reaction characterized by the rapid and transient production of a large amount of reactive oxygen species (ROS) occurs following the pathogen infection/toxin exposure. The maximum concentration of hydrogen peroxide (H 2 O 2 ) produced was reported in the pathogen infected samples (22.2-fold) at 24 h post inoculation followed by TeA (18.2-fold), AOH (15.9-fold), and AME (14.1-fold) in treated tissues. 3,3'- Diaminobenzidine staining predicted the possible sites of H 2 O 2 accumulation while the extent of cell death was measured by Evans blue dye. The extent of lipid peroxidation and malondialdehyde (MDA) content was higher (15.8-fold) at 48 h in the sample of inoculated leaves of the pathogen when compared to control. The cellular damages were observed as increased MDA content and reduced chlorophyll. The activities of antioxidative defense enzymes increased in both the pathogen infected as well as toxin treated samples. Superoxide dismutase (SOD) activity was 5.9-fold higher at 24 h post inoculation in leaves followed by TeA (5.0-fold), AOH (4.1-fold) and AME (2.3-fold) treated leaves than control. Catalase (CAT) activity was found to be increased upto 48 h post inoculation and maximum in the pathogen challenged samples followed by other toxins. The native PAGE results showed the variations in the intensities of isozyme (SOD and CAT) bands in the pathogen infected and toxin treated samples. Ascorbate peroxidase (APx) and glutathione reductase (GR) activities followed the similar trend to scavenge the excess H 2 O 2 . The reduction in CAT

  4. Elastic and inelastic scattering of 9,11 Li + Si at backward angles in the energy range (9.5 - 25) AMeV

    International Nuclear Information System (INIS)

    Petrascu, M.; Bordeanu, C.; Isbasescu, A.; Mihai, I.; Giurgiu, M.

    1997-01-01

    Recently, an inclusive fusion experiment of 9,11 Li projectiles with Si targets, in the energy range (9.5 - 25) AMeV has been performed at Riken Ring Cyclotron-Japan using, for the detection of the fusion products, an ionization chamber, MUSIC, built in NIPNE-HH, Bucharest. In this experiment, the contribution of elastic and inelastic scattering, at forward detection angles is eliminated through the experimental set-up. For a clear investigation of the fusion process, the estimation of elastic and inelastic scattering at backward angles, between 80 angle - 180 angle was considered necessary. This estimation was made by the coupled channels computer code ECIS. ECIS is an iterative method, the first iteration of this procedure being DWBA. In the analysis of elastic and inelastic scattering of 9,11 Li projectile on Si target we assumed that the incident 9 Li and 11 Li waves are diffracted by an optical potential with an Woods-Saxon geometry. The adopted optical potential is given. For the depth of the real and imaginary volume terms we used values dependent on projectile energy and target mass number. These values have been chosen in good agreement with a semi-microscopic model with a double-folding potential. The set of optical parameters selected for the system 9,11 Li (13 AMeV) + Si is given. The presence of neutron halo of 11 Li nucleus was taken into account by using adjusted values for the parameters r R and a R . The 28 Si nucleus is considered a rigid rotor, including the couplings involving the ground state and a first to excited states. The quadrupole deformation parameter was β 2 = - 0.24. The results for the scattering of 11 Li projectile on Si target at 13 AMeV energy are given with the parameters R match , I and J max taken from the Monte Carlo simulations with PACE code. We found that the contribution of elastic and inelastic scattering for background angles, between 80 angle - 180 angle is under 2%. The contribution of a inelastic scattering taken

  5. [Evaluation of the mutagenicity of detergents by tests on bacteria, plant cells and human leucocytes.].

    Science.gov (United States)

    Feretti, Donatella; Pedrazzani, Roberta; Ceretti, Elisabetta; Zerbini, Ilaria; Gozio, Eleonora; Belotti, Caterina; Alias, Carlotta; Donato, Francesco; Gelatti, Umberto

    2009-01-01

    The aim of this study was to evaluate the mutagenicity of several traditional detergents and that of newer more biodegradable detergents, by using a bacterial test (Ames test), a plant cell test (Allium cepa micronuclei test) and a human leucocyte test (Comet test). All tests were conducted using a wide range of doses (1-2000 mg/l). None of the examined detergents induced mutations in S.typhimurium. One traditional detergent showed a genotoxic effect with the A. cepa test, while all newer detergents and one traditional detergent were shown by the Comet test to be capable of inducing DNA damage.

  6. The NASA Ames PAH IR Spectroscopic Database: Computational Version 3.00 with Updated Content and the Introduction of Multiple Scaling Factors

    Science.gov (United States)

    Bauschlicher, Charles W., Jr.; Ricca, A.; Boersma, C.; Allamandola, L. J.

    2018-02-01

    Version 3.00 of the library of computed spectra in the NASA Ames PAH IR Spectroscopic Database (PAHdb) is described. Version 3.00 introduces the use of multiple scale factors, instead of the single scaling factor used previously, to align the theoretical harmonic frequencies with the experimental fundamentals. The use of multiple scale factors permits the use of a variety of basis sets; this allows new PAH species to be included in the database, such as those containing oxygen, and yields an improved treatment of strained species and those containing nitrogen. In addition, the computed spectra of 2439 new PAH species have been added. The impact of these changes on the analysis of an astronomical spectrum through database-fitting is considered and compared with a fit using Version 2.00 of the library of computed spectra. Finally, astronomical constraints are defined for the PAH spectral libraries in PAHdb.

  7. A Tale of Two Small Business Grants: The Best of Times, the Worst of Times from the NASA Ames Small Business Innovative Research (SBIR) Program

    Science.gov (United States)

    Kojiro, Daniel R.; Lee, Geoffrey S.

    2006-01-01

    The purposes of the SBIR Program are to: stimulate technological innovation in the private sector; strengthen the role of Small Business Concerns (SBCs) in meeting Federal research and development needs; increase the commercial application of these research results; and encourage participation of socially and economically disadvantaged persons and women-owned small businesses. The process can be highly rewarding, providing the small business with resources to pursue research and development with a focus on providing NASA with new and advanced capabilities. We present two examples of how the NASA Ames SBIR Program has addressed these purposes, nurturing innovative ideas from small, businesses into commercially viable products that also address analytical needs in space research. These examples, from the Science Instruments for Conducting Solar System Exploration Subtopic, describe the journey from innovative concept to analytical instrument, one successful and one hampered by numerous roadblocks (including some international intrigue}.

  8. I. The properties of hot Ca-like fragments from the 40Ca+40Ca reaction at 35 AMeV

    International Nuclear Information System (INIS)

    Planeta, R.; Gawlikowicz, W.; Wieloch, A.

    2001-01-01

    The creation of hot Ca-like fragments was investigated in the 40 Ca + 40 Ca reaction at 35 AMeV. Using the AMPHORA 4π detector system, the primary projectile-like fragment was reconstructed and its properties were determined. Both primary and secondary distributions are compared with the predictions of a Monte Carlo code describing a heavy-ion collision as a two-step process. Some of the nucleons which are identified as participants in the first step are transferred in the second step to these final states, which correspond on the average to the maximum value of entropy (thermodynamic probability). The model allows for competition between mean-field effects and nucleon-nucleon interactions in the overlap zone of the interacting nuclei. The analysis presented here suggests a thermalized source picture of the decay of the projectile-like fragment. The validity of the reconstruction procedure for projectile-like fragments is discussed. (orig.)

  9. Results of screening NCI/NTP nongenotoxic carcinogens and genotoxic noncarcinogens with the k sub e test

    Energy Technology Data Exchange (ETDEWEB)

    Mendelsohn, M.L. (ed.); Bakale, G.; McCreary, R.D.

    1989-01-01

    The interdependence of the electrophilic and carcinogenic properties of chemicals that was demonstrated two decades ago rekindled interest in the somatic mutation theory of carcinogenesis. Interest in this theory grew with the development of a reverse-mutation bacterial assay in the laboratory of B.N. Ames that permitted the mutagenic properties of the chemicals to be determined quickly and yielded results which indicated that carcinogens are mutagens.'' Subsequent validation studies of this bioassay, the Salmonella typhimurium/microsome or Ames test,'' by Ames' group and others provided additional support for the correlation between mutagenicity and carcinogenicity which led to the worldwide deployment of the Ames test in thousands of laboratories and to the development of more than 100 other short-term tests that continue to be used to identify potential carcinogens via various end-points of genotoxicity. This document discusses electrophilicity, mutagenicity, and carcinogenicity relationships as well as carcinogen-screening of chemicals. 28 refs., 4 tabs.

  10. Integrated Test and Evaluation (ITE) Flight Test Series 4

    Science.gov (United States)

    Marston, Michael

    2016-01-01

    The integrated Flight Test 4 (FT4) will gather data for the UAS researchers Sense and Avoid systems (referred to as Detect and Avoid in the RTCA SC 228 ToR) algorithms and pilot displays for candidate UAS systems in a relevant environment. The technical goals of FT4 are to: 1) perform end-to-end traffic encounter test of pilot guidance generated by DAA algorithms; 2) collect data to inform the initial Minimum Operational Performance Standards (MOPS) for Detect and Avoid systems. FT4 objectives and test infrastructure builds from previous UAS project simulations and flight tests. NASA Ames (ARC), NASA Armstrong (AFRC), and NASA Langley (LaRC) Research Centers will share responsibility for conducting the tests, each providing a test lab and critical functionality. UAS-NAS project support and participation on the 2014 flight test of ACAS Xu and DAA Self Separation (SS) significantly contributed to building up infrastructure and procedures for FT3 as well. The DAA Scripted flight test (FT4) will be conducted out of NASA Armstrong over an eight-week period beginning in April 2016.

  11. Genotoxicity testing of samples generated during UV/H2O2 treatment of surface water for the production of drinking water using the Ames test in vitro and the Comet assay and the SCE test in vivo

    NARCIS (Netherlands)

    Penders, E.J.M.; Martijn, A.J.; Spenkelink, A.; Alink, G.M.; Rietjens, I.; Hoogenboezem, W.

    2012-01-01

    UV/H2O2 treatment can be part of the process converting surface water to drinking water, but would pose a potential problem when resulting in genotoxicity. This study investigates the genotoxicity of samples collected from the water treatment plant Andijk, applying UV/H2O2 treatment with an

  12. The role of the Joint Research Centre from the European Commission in the European Structural Integrity Networks AMES, ENIQ and NESC

    International Nuclear Information System (INIS)

    Estorff, U. von; Torronen, K.

    1999-01-01

    Due to the reduction in many countries of the research budget for nuclear safety several European institutions and organisations and the Institute for Advanced Materials (IAM) of the Joint Research Centre (JRC) of the European Commission (EC) have developed co-operative programmes now organised into 'Networks' for mutual benefit. They include utilities, engineering companies, research and development (R and D) laboratories and regulatory bodies. These Networks are all organised and managed in a similar way, i.e. like the successful Programme for the Inspection of Steel Components (PISC). The IAM plays the role of Operating Agent, Reference Laboratory and Network Manager of these Networks: European Network on Ageing Materials Evaluation and Studies (AMES), European Network for Inspection Qualification (ENIQ) and Network for Evaluating Steel Components (NESC), each of them dealing with a specific aspect of fitness for purpose of materials in structural components. This article will describe how the network organisation works, which was the positive experience from the past, why the networks are a tool for integrating fragmented research in Europe and how they fit into the mission of the JRC and therefore follow the EC policy. (orig.)

  13. Control-value theory: using achievement emotions to improve understanding of motivation, learning, and performance in medical education: AMEE Guide No. 64.

    Science.gov (United States)

    Artino, Anthony R; Holmboe, Eric S; Durning, Steven J

    2012-01-01

    In this AMEE Guide, we consider the emergent theoretical and empirical work on human emotion and how this work can inform the theory, research, and practice of medical education. In the Guide, we define emotion, in general, and achievement emotions, more specifically. We describe one of the leading contemporary theories of achievement emotions, control-value theory (Pekrun 2006), and we distinguish between different types of achievement emotions, their proximal antecedents, and their consequences for motivation, learning, and performance. Next, we review the empirical support for control-value theory from non-medical fields and suggest several important implications for educational practice. In this section, we highlight the importance of designing learning environments that foster a high degree of control and value for students. Finally, we end with a discussion of the need for more research on achievement emotions in medical education, and we propose several key research questions we believe will facilitate our understanding of achievement emotions and their impact on important educational outcomes.

  14. Isospin influence on the decay modes of the systems produced in the 78,86Kr +40,48Ca reactions at 10 AMeV

    Directory of Open Access Journals (Sweden)

    Gnoffo B.

    2016-01-01

    Full Text Available The results of the analysis of the reactions 78,86Kr +40,48 Ca at 10 AMeV are presented. The experiment was performed at the INFN Laboratori Nazionali del Sud (LNS in Catania by using the 4π multidetector CHIMERA, with beams delivered by the Superconductive Cyclotron. The competition among the various disintegration paths and in particular the isospin effects on the decay modes of the produced composite systems are investigated; this provides information about fundamental nuclear quantities such as level density, fission barrier and viscosity. Different isotopic composition and relative richness are observed among the reaction products of the two systems. An odd-even staggering effect is present in the charge distributions, in particular for the light fragments produced by the neutron-poor system. The kinematical characteristics of the IMF seem to indicate a high degree of the relaxation of the formed system. Besides, global features analysis seems to show some differences in the contribution arising from the various reaction mechanisms for the two reactions.

  15. Measurement of neutron spectra generated by a 62 AMeV carbon-ion beam on a PMMA phantom using extended range Bonner sphere spectrometers

    International Nuclear Information System (INIS)

    Bedogni, R.; Amgarou, K.; Domingo, C.; Russo, S.; Cirrone, G.A.P.; Pelliccioni, M.; Esposito, A.; Pola, A.; Introini, M.V.; Gentile, A.

    2012-01-01

    Neutrons constitute an important component of the radiation environment in hadron therapy accelerators. Their energy distribution may span from thermal up to hundred of MeV. The characterization of these fields in terms of dosimetric or spectrometric quantities is crucial for either the patient protection or the facility design aspects. To date, the Extended Range Bonner Sphere Spectrometer (ERBSS) is the only instrument able to simultaneously determine all spectral components in such workplaces. With the aim of providing useful data to the scientific community involved in neutron measurements at hadron therapy facilities, a measurement campaign was carried out at the Centro di AdroTerapia e Applicazioni Nucleari Avanzate (CATANA) of INFN-LNS (Laboratori Nazionali del Sud), where a 62 AMeV carbon ion is available. The beam was directed towards a PMMA phantom, simulating the patient, and two neutron measurement points were established at 0° and 90° with respect to the beam-line. The ERBSSs of UAB (Universidad Autónoma de Barcelona-Grup de Física de les Radiacions) and INFN (Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali di Frascati) were used to measure the resulting neutron fields. The two ERBSSs use different detectors and sphere diameters, and have been independently calibrated. The FRUIT code was used to unfold the results.

  16. Measurement of neutron spectra generated by a 62 AMeV carbon-ion beam on a PMMA phantom using extended range Bonner sphere spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    Bedogni, R., E-mail: roberto.bedogni@lnf.infn.it [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati, Via E. Fermi 40, 00044 Frascati (Italy); Amgarou, K.; Domingo, C. [Grup de Recerca en Radiacions Ionitzants, Departament de Fisica, Universitat Autonoma de Barcelona, E-08193 Bellaterra (Spain); Russo, S.; Cirrone, G.A.P. [Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali dei Sud, Via S. Sofia 62, 95125 Catania (Italy); Pelliccioni, M.; Esposito, A. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati, Via E. Fermi 40, 00044 Frascati (Italy); Pola, A.; Introini, M.V. [Politecnico di Milano, CESNEF, Dipartimento di Energia, via Ponzio 34/3, 20133 Milano (Italy); Gentile, A. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati, Via E. Fermi 40, 00044 Frascati (Italy)

    2012-07-21

    Neutrons constitute an important component of the radiation environment in hadron therapy accelerators. Their energy distribution may span from thermal up to hundred of MeV. The characterization of these fields in terms of dosimetric or spectrometric quantities is crucial for either the patient protection or the facility design aspects. To date, the Extended Range Bonner Sphere Spectrometer (ERBSS) is the only instrument able to simultaneously determine all spectral components in such workplaces. With the aim of providing useful data to the scientific community involved in neutron measurements at hadron therapy facilities, a measurement campaign was carried out at the Centro di AdroTerapia e Applicazioni Nucleari Avanzate (CATANA) of INFN-LNS (Laboratori Nazionali del Sud), where a 62 AMeV carbon ion is available. The beam was directed towards a PMMA phantom, simulating the patient, and two neutron measurement points were established at 0 Degree-Sign and 90 Degree-Sign with respect to the beam-line. The ERBSSs of UAB (Universidad Autonoma de Barcelona-Grup de Fisica de les Radiacions) and INFN (Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali di Frascati) were used to measure the resulting neutron fields. The two ERBSSs use different detectors and sphere diameters, and have been independently calibrated. The FRUIT code was used to unfold the results.

  17. Measurement of neutron spectra generated by a 62 AMeV carbon-ion beam on a PMMA phantom using extended range Bonner sphere spectrometers

    Science.gov (United States)

    Bedogni, R.; Amgarou, K.; Domingo, C.; Russo, S.; Cirrone, G. A. P.; Pelliccioni, M.; Esposito, A.; Pola, A.; Introini, M. V.; Gentile, A.

    2012-07-01

    Neutrons constitute an important component of the radiation environment in hadron therapy accelerators. Their energy distribution may span from thermal up to hundred of MeV. The characterization of these fields in terms of dosimetric or spectrometric quantities is crucial for either the patient protection or the facility design aspects. To date, the Extended Range Bonner Sphere Spectrometer (ERBSS) is the only instrument able to simultaneously determine all spectral components in such workplaces. With the aim of providing useful data to the scientific community involved in neutron measurements at hadron therapy facilities, a measurement campaign was carried out at the Centro di AdroTerapia e Applicazioni Nucleari Avanzate (CATANA) of INFN-LNS (Laboratori Nazionali del Sud), where a 62 AMeV carbon ion is available. The beam was directed towards a PMMA phantom, simulating the patient, and two neutron measurement points were established at 0° and 90° with respect to the beam-line. The ERBSSs of UAB (Universidad Autónoma de Barcelona-Grup de Física de les Radiacions) and INFN (Istituto Nazionale di Fisica Nucleare-Laboratori Nazionali di Frascati) were used to measure the resulting neutron fields. The two ERBSSs use different detectors and sphere diameters, and have been independently calibrated. The FRUIT code was used to unfold the results.

  18. Proposed Use of the NASA Ames Nebula Cloud Computing Platform for Numerical Weather Prediction and the Distribution of High Resolution Satellite Imagery

    Science.gov (United States)

    Limaye, Ashutosh S.; Molthan, Andrew L.; Srikishen, Jayanthi

    2010-01-01

    The development of the Nebula Cloud Computing Platform at NASA Ames Research Center provides an open-source solution for the deployment of scalable computing and storage capabilities relevant to the execution of real-time weather forecasts and the distribution of high resolution satellite data to the operational weather community. Two projects at Marshall Space Flight Center may benefit from use of the Nebula system. The NASA Short-term Prediction Research and Transition (SPoRT) Center facilitates the use of unique NASA satellite data and research capabilities in the operational weather community by providing datasets relevant to numerical weather prediction, and satellite data sets useful in weather analysis. SERVIR provides satellite data products for decision support, emphasizing environmental threats such as wildfires, floods, landslides, and other hazards, with interests in numerical weather prediction in support of disaster response. The Weather Research and Forecast (WRF) model Environmental Modeling System (WRF-EMS) has been configured for Nebula cloud computing use via the creation of a disk image and deployment of repeated instances. Given the available infrastructure within Nebula and the "infrastructure as a service" concept, the system appears well-suited for the rapid deployment of additional forecast models over different domains, in response to real-time research applications or disaster response. Future investigations into Nebula capabilities will focus on the development of a web mapping server and load balancing configuration to support the distribution of high resolution satellite data sets to users within the National Weather Service and international partners of SERVIR.

  19. Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro.

    Science.gov (United States)

    Armstrong, Vanessa L; Rakoczy, Sharlene; Rojanathammanee, Lalida; Brown-Borg, Holly M

    2014-08-01

    Methyltransferase expression and DNA methylation are linked to aging and age-related disease. We utilized 3-, 12-, and 24-month-old Ames dwarf and their wild-type siblings to examine the genotype and age-related differences in the expression of methyltransferase enzymes related to DNA methylation in the liver, glycine-N-methyltransferase and DNA methyltransferase (DNMT). We found that DNMT proteins and transcripts are differentially expressed in dwarf mice compared with wild-type siblings that can be attributed to age and/or genotype. However, DNMT1 protein expression is drastically reduced compared with wild-type controls at every age. DNMT3a protein levels coincide with differences observed in DNMT activity. Growth hormone appears to modulate expression of DNMT1 and 3a in dwarf liver tissue and primary hepatocytes. Therefore, growth hormone may contribute to age-related processes, DNA methylation, and, ultimately, longevity. © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  20. Analysis and characterization of heavy residues produced in 129Xe + natSn reactions between 8 and 25 AMeV

    International Nuclear Information System (INIS)

    Moisan, J.

    2008-06-01

    Studies with the INDRA multidetector of the 129 Xe + nat Sn reactions showed the unexpected existence of heavy fragments with a charge as large as Z=70. The charges of Xe and Sn are 54 and 50 respectively. Reactions between nuclei with a charge product greater than 2700 are dominated by deep inelastic collisions. For Xe + Sn the product is exactly 2700. After these observations, 129 Xe + nat Sn reactions at 8, 12, 15, 20 and 25 AMeV have been done. It will then be possible to clarify if the heavy residues are formed by an incomplete fusion, massive transfers occurring in deep inelastic collisions or a very asymmetric fission of a compound system. This work will present experimental results obtained by the analysis of these experiments. We will show that heavy residues are formed with a production cross-section of 10 -2 mb. Angular distributions show that the residues can be produced by an incomplete fusion of the projectile and the target. The study of the products in coincidence with the residues shows that a compound system was formed, followed by a fission producing the residue and a lighter fragment. The comparison with a phenomenological model, HIPSE, confirms that the model is valid at these energies

  1. Aging material evaluation and studies by non-destructive techniques (AMES-NDT) - a European network project

    International Nuclear Information System (INIS)

    Dobmann, Gerd; Debarberis, Luigi; Coste, Jean-Francois

    2001-01-01

    This paper presents results obtained in a round-robin action organized in a concerted action of ten partners in the EURATOM program of the European Community. The objective of the research was to document the state of the art of available non-destructive testing (NDT) techniques in order to characterize material aging phenomena based on a reduction of Charpy-V energy and a shift in the fracture appearance transition temperature. Therefore, samples from the Japanese nuclear reactor pressure vessel JRQ-steel (ASMT Standard A533-B Class 1) have been thermally treated at 700 deg. C for 18 h with a subsequent water quenching. Besides micromagnetic and electromagnetic NDT, the positron annihilation technique, ultrasonic reverberation by using Laser ultrasonics and the thermo-electrical power have been applied to characterize the aged material states

  2. Testing and Analysis of the First Plastic Melt Waste Compactor Prototype

    Science.gov (United States)

    Pace, Gregory S.; Fisher, John W.

    2005-01-01

    A half scale Plastic Melt Waste Compactor prototype has been developed at NASA Ames Research Center. The half scale prototype unit will lead to the development of a full scale Plastic Melt Waste Compactor prototype that is representative of flight hardware that would be used on near and far term space missions. This report details the testing being done on the prototype Plastic Melt Waste Compactor by the Solid Waste Management group at NASA Ames Research Center. The tests are designed to determine the prototype's functionality, simplicity of operation, ability to contain and control noxious off-gassing, biological stability of the processed waste, and water recovery potential using a waste composite that is representative of the types of wastes produced on the International Space Station, Space Shuttle, MIR and Skylab missions.

  3. 2011 Ground Testing Highlights Article

    Science.gov (United States)

    Ross, James C.; Buchholz, Steven J.

    2011-01-01

    Two tests supporting development of the launch abort system for the Orion MultiPurpose Crew Vehicle were run in the NASA Ames Unitary Plan wind tunnel last year. The first test used a fully metric model to examine the stability and controllability of the Launch Abort Vehicle during potential abort scenarios for Mach numbers ranging from 0.3 to 2.5. The aerodynamic effects of the Abort Motor and Attitude Control Motor plumes were simulated using high-pressure air flowing through independent paths. The aerodynamic effects of the proximity to the launch vehicle during the early moments of an abort were simulated with a remotely actuated Service Module that allowed the position relative to the Crew Module to be varied appropriately. The second test simulated the acoustic environment around the Launch Abort Vehicle caused by the plumes from the 400,000-pound thrust, solid-fueled Abort Motor. To obtain the proper acoustic characteristics of the hot rocket plumes for the flight vehicle, heated Helium was used. A custom Helium supply system was developed for the test consisting of 2 jumbo high-pressure Helium trailers, a twelve-tube accumulator, and a 13MW gas-fired heater borrowed from the Propulsion Simulation Laboratory at NASA Glenn Research Center. The test provided fluctuating surface pressure measurements at over 200 points on the vehicle surface that have now been used to define the ground-testing requirements for the Orion Launch Abort Vehicle.

  4. Western aeronautical test range real-time graphics software package MAGIC

    Science.gov (United States)

    Malone, Jacqueline C.; Moore, Archie L.

    1988-01-01

    The master graphics interactive console (MAGIC) software package used on the Western Aeronautical Test Range (WATR) of the NASA Ames Research Center is described. MAGIC is a resident real-time research tool available to flight researchers-scientists in the NASA mission control centers of the WATR at the Dryden Flight Research Facility at Edwards, California. The hardware configuration and capabilities of the real-time software package are also discussed.

  5. Evaluación de métodos para la conservación de hongos fitopatógenos del ñame (Dioscorea sp.

    Directory of Open Access Journals (Sweden)

    Yeimy Alexandra Pinzón Gutiérrez

    2009-07-01

    Full Text Available Un elemento esencial en la investigación con microorganismos fitopatógenos es su conservación y uso seguro. Desde este punto de vista, en este estudio se evaluaron métodos de conservación de hongos que atacan el ñame, empleando como factores de respuesta el potencial de viabilidad, y la estabilidad y presencia o ausencia de cambios en las características macro y microscópicas. Como resultado del trabajo se proponen los métodos más adecuados para los géneros Colletotrichum y Fusarium, hongos causantes de las mayores pérdidas en las plantaciones de ñame en la Costa Caribe colombiana. Las cepas utilizadas en este estudio provienen de las colecciones de la Universidad de Sucre, del Instituto de Biotecnología de la Universidad Nacional de Colombia (IBUN y de una donación de la doctora Lucía Afanador de la Universidad Nacional, Sede Medellín. Estas fueron sometidas a diferentes métodos de conservación, entre ellos criopreservación, liofilización y cultivo periódico con y sin aceite mineral. Los resultados obtenidos permitieron elegir la criopreservación como el método más eficiente para la conservación de la colección, y el cultivo periódico con aceite mineral como método alternativo y complementario. Estos minimizan el riesgo de pérdida del material biológico y brindan condiciones de manejo que conservan las características biológicas bajo estudio desde campos como la microbiología, la bioquímica y la biología molecular, entre otros. An essential element in phytopathogenic microorganism research is their preservation and safe use. The purpose of this study was to evaluate methods for preserving fungi producing diseases in yam, using potential viability, stability and the presence or absence of macro- and microscopic characteristic changes as response factors. More suitable methods for Colletotrichum and Fusarium genera were proposed as a result of the work; these are fungi causing the greatest losses in yam

  6. A simple model for yield prediction of rice based on vegetation index derived from satellite and AMeDAS data during ripening period

    International Nuclear Information System (INIS)

    Wakiyama, Y.; Inoue, K.; Nakazono, K.

    2003-01-01

    The present study was conducted to show a simple model for rice yield predicting by using a vegetation index (NDVI) derived from satellite and meteorological data. In a field experiment, the relationship between the vegetation index and radiation absorbed by the rice canopy was investigated from transplanting to maturity. Their correlation held. This result revealed that the vegetation index could be used as a measure of absorptance of solar radiation by rice canopy. NDVI multiplied by solar radiation (SR) every day was accumulated (Σ(SR·NDVI)) from the field experiment. Σ(SR·NDVI) was plotted against above ground dry matter. It was obvious that they had a strong relationship. Rice yield largely depends on solar radiation and air temperature during the ripening period. Air temperature affects dry matter production. Relationships between Y SR -1 (Y: rice yield, SR: solar radiation) and mean air temperature were investigated from meteorological data and statistical data on rice yield. There was an optimum air temperature, 21.3°C, for ripening. When it was near 21.3°C in the ripening period, the rice yield was higher. We proposed a simple model for yield prediction of rice based on these results. The model is composed with SR·NDVI and the optimum air temperature. Vegetation index was derived from 3 years, LANDSAT TM data in Toyama, Ishikawa, Fukui and Nagano prefectures at heading. The meteorological data was used from AMeDAS data. The model was described as follows: Y = 0.728 SR·NDVI−2.04(T−21.3) 2 + 282 (r 2 = 0.65, n = 43) where Y is rice yield (kg 10a -1 ), SR is solar radiation (MJ m -2 ) during the ripening period (from 10 days before heading to 30 days after heading), T is mean air temperature (°C) during the ripening period. RMSE was 33.7kg 10a -1 . The model revealed good precision. (author)

  7. The Mars Dust Cycle: Investigating the Effects of Radiatively Active Water Ice Clouds on Surface Stresses and Dust Lifting Potential with the NASA Ames Mars General Circulation Model

    Science.gov (United States)

    Kahre, Melinda A.; Hollingsworth, Jeffery

    2012-01-01

    The dust cycle is a critically important component of Mars' current climate system. Dust is present in the atmosphere of Mars year-round but the dust loading varies with season in a generally repeatable manner. Dust has a significant influence on the thermal structure of the atmosphere and thus greatly affects atmospheric circulation. The dust cycle is the most difficult of the three climate cycles (CO2, water, and dust) to model realistically with general circulation models. Until recently, numerical modeling investigations of the dust cycle have typically not included the effects of couplings to the water cycle through cloud formation. In the Martian atmosphere, dust particles likely provide the seed nuclei for heterogeneous nucleation of water ice clouds. As ice coats atmospheric dust grains, the newly formed cloud particles exhibit different physical and radiative characteristics. Thus, the coupling between the dust and water cycles likely affects the distributions of dust, water vapor and water ice, and thus atmospheric heating and cooling and the resulting circulations. We use the NASA Ames Mars GCM to investigate the effects of radiatively active water ice clouds on surface stress and the potential for dust lifting. The model includes a state-of-the-art water ice cloud microphysics package and a radiative transfer scheme that accounts for the radiative effects of CO2 gas, dust, and water ice clouds. We focus on simulations that are radiatively forced by a prescribed dust map, and we compare simulations that do and do not include radiatively active clouds. Preliminary results suggest that the magnitude and spatial patterns of surface stress (and thus dust lifting potential) are substantial influenced by the radiative effects of water ice clouds.

  8. The use of an automated flight test management system in the development of a rapid-prototyping flight research facility

    Science.gov (United States)

    Duke, Eugene L.; Hewett, Marle D.; Brumbaugh, Randal W.; Tartt, David M.; Antoniewicz, Robert F.; Agarwal, Arvind K.

    1988-01-01

    An automated flight test management system (ATMS) and its use to develop a rapid-prototyping flight research facility for artificial intelligence (AI) based flight systems concepts are described. The ATMS provides a flight test engineer with a set of tools that assist in flight planning and simulation. This system will be capable of controlling an aircraft during the flight test by performing closed-loop guidance functions, range management, and maneuver-quality monitoring. The rapid-prototyping flight research facility is being developed at the Dryden Flight Research Facility of the NASA Ames Research Center (Ames-Dryden) to provide early flight assessment of emerging AI technology. The facility is being developed as one element of the aircraft automation program which focuses on the qualification and validation of embedded real-time AI-based systems.

  9. Interstellar matter in Shapley-Ames elliptical galaxies. IV. A diffusely distributed component of dust and its effect on colour gradients.

    Science.gov (United States)

    Goudfrooij, P.; de Jong, T.

    1995-06-01

    We have investigated IRAS far-infrared observations of a complete, blue magnitude limited sample of 56 elliptical galaxies selected from the Revised Shapley-Ames Catalog. Data from a homogeneous optical CCD imaging survey as well as published X-ray data from the EINSTEIN satellite are used to constrain the infrared data. Dust masses as determined from the IRAS flux densities are found to be roughly an order of magnitude higher than those determined from optical extinction values of dust lanes and patches, in strong contrast with the situation in spiral galaxies. This "mass discrepancy" is found to be independent of the (apparent) inclination of the dust lanes. To resolve this dilemma we postulate that the majority of the dust in elliptical galaxies exists as a diffusely distributed component of dust which is undetectable at optical wavelengths. Using observed radial optical surface brightness profiles, we have systematically investigated possible heating mechanisms for the dust within elliptical galaxies. We find that heating of the dust in elliptical galaxies by the interstellar radiation field is generally sufficient to account for the dust temperatures as indicated by the IRAS flux densities. Collisions of dust grains with hot electrons in elliptical galaxies which are embedded in a hot, X-ray-emitting gas is found to be another effective heating mechanism for the dust. Employing model calculations which involve the transfer of stellar radiation in a spherical distribution of stars mixed with a diffuse distribution of dust, we show that the observed infrared luminosities imply total dust optical depths of the postulated diffusely distributed dust component in the range 0.1<~τ_V_<~0.7 and radial colour gradients 0.03<~{DELTA}(B-I)/{DELTA}log r<~0.25. The observed IRAS flux densities can be reproduced within the 1σ uncertainties in virtually all ellipticals in this sample by this newly postulated dust component, diffusely distributed over the inner few kpc of

  10. Participación política y violencia de género en América Latina

    Directory of Open Access Journals (Sweden)

    Laura Albaine

    2014-07-01

    Full Text Available Este artículo reflexiona a través del análisis de fac- tores socioculturales e institucionales sobre uno de los obstáculos más graves que condicionan la participación política de las mujeres en América Latina: El acoso y vio- lencia política en razón de género. Esta problemática es una nueva expresión que ha adoptado la violencia de gé- nero en la arena política que restringe el ejercicio de los derechos políticos de las mujeres y el derecho a vivir una vida libre de violencia. El acoso y violencia política se manifiesta más allá de los avances normativos logrados en la región orientados a generar condiciones de igualdad en términos de género en la participación política. En consecuencia, a las nor- mas que promueven el acceso de las mujeres a cargos de decisión, tales como cuotas o paridad, deben sumársele cuerpos legales que garanticen, además de sus derechos políticos, su seguridad y sus derechos humanos. AbstractThis paper focuses on a reflection and analysis of socio-cultural and institutional factors that affect wom- en’s political participation Latin America, such as gen- der-based harassment and violence. This problem is a new expression that has adopted gender-based violence in political arena, restricting not only the exercise of women’s political rights but also their right to live a life free of violence. Despite Latin American countries have enacted laws to create conditions in terms of gender equality in polit- ical participation, political harassment and violence still occurs. However, these policy actions are not enough to ensure women’s access to decision-making positions, such as quotas or parity; it must also be legal bodies to ensure, in addition to their political rights, their personal safety and human rights. 

  11. Biological Visualization, Imaging and Simulation(Bio-VIS) at NASA Ames Research Center: Developing New Software and Technology for Astronaut Training and Biology Research in Space

    Science.gov (United States)

    Smith, Jeffrey

    2003-01-01

    The Bio- Visualization, Imaging and Simulation (BioVIS) Technology Center at NASA's Ames Research Center is dedicated to developing and applying advanced visualization, computation and simulation technologies to support NASA Space Life Sciences research and the objectives of the Fundamental Biology Program. Research ranges from high resolution 3D cell imaging and structure analysis, virtual environment simulation of fine sensory-motor tasks, computational neuroscience and biophysics to biomedical/clinical applications. Computer simulation research focuses on the development of advanced computational tools for astronaut training and education. Virtual Reality (VR) and Virtual Environment (VE) simulation systems have become important training tools in many fields from flight simulation to, more recently, surgical simulation. The type and quality of training provided by these computer-based tools ranges widely, but the value of real-time VE computer simulation as a method of preparing individuals for real-world tasks is well established. Astronauts routinely use VE systems for various training tasks, including Space Shuttle landings, robot arm manipulations and extravehicular activities (space walks). Currently, there are no VE systems to train astronauts for basic and applied research experiments which are an important part of many missions. The Virtual Glovebox (VGX) is a prototype VE system for real-time physically-based simulation of the Life Sciences Glovebox where astronauts will perform many complex tasks supporting research experiments aboard the International Space Station. The VGX consists of a physical display system utilizing duel LCD projectors and circular polarization to produce a desktop-sized 3D virtual workspace. Physically-based modeling tools (Arachi Inc.) provide real-time collision detection, rigid body dynamics, physical properties and force-based controls for objects. The human-computer interface consists of two magnetic tracking devices

  12. Protocolo para la formación de microtubérculos de ñame (Dioscorea alata L. en sistema de inmersión temporal

    Directory of Open Access Journals (Sweden)

    Manuel Cabrera Jova

    2009-07-01

    Full Text Available Con el propósito de desarrollar un protocolo para la formación de microtubérculos en el clon de ñame Pacala Duclos (Dioscorea alata L. en sistema de inmersión temporal, que pudiera ser usado como alternativa para la propagación de esta especie, se definieron como objetivos de trabajo determinar el efecto del tiempo y la frecuencia de inmersión, así como la influencia del volumen de medio de cultivo por planta cultivada in vitro. Con el empleo de 15 min de inmersión y una frecuencia de inmersión cada 6 horas, se alcanzaron los mejores resultados en cuanto al número de microtubérculos formados por planta. Con este tiempo y frecuencia de inmersión los microtubérculos presentaron la mayor masa fresca y seca, así como el mayor diámetro. Además, a las 18 semanas de cultivo se obtuvo el mayor número total de microtubérculos por sistema y el mayor número de microtubérculos aprovechables como material vegetal de propagación. En cuanto al volumen de medio de cultivo por planta, con 60 ml de medio de cultivo por planta in vitro se alcanzó el mayor número de microtubérculos aprovechables, los cuales presentaron el contenido más alto de materia seca. Los microtubérculos obtenidos en este tipo de sistema de inmersión temporal presentaron una masa fresca superior a 2,40 gMF, lo cual podría permitir su uso como material de plantación directo a campo.Abreviaturas: sistema de inmersión temporal (SIT, gramos de masa fresca (gMF, recipiente de inmersión temporal automatizado (RITA.

  13. Measurement of isotopic cross sections of the fission fragments produced in 500 AMeV {sup 208}Pb + p reaction; Etude de la production des fragments de fission issus de la reaction {sup 208}Pb + p a 500 AMeV

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Dominguez, B

    2003-03-01

    The aim of this work is the study of the fission fragments produced in the spallation reaction {sup 208}Pb + p at 500 AMeV. The fission fragments from Z=23 up to Z=59 have been detected and identified by using the inverse kinematics technique with the high-resolution spectrometer FRS. The production cross sections and the recoil velocities of 430 nuclei have been measured. The measured data have been compared with previous data. The isotopic distributions show a high precision. However, the absolute value of the fission cross section is higher than expected. From the experimental data the characteristics of the average fissioning system have been reconstructed (Z{sub fis}, A{sub fis}, E*{sub fis}). In addition, the number of post-fission neutrons emitted from the fission fragments, v{sub post}, has been determined by using a new method. The experimental data have been compared to the two-steps models describing the spallation reaction. The impact of the model parameters on the observables has been analysed and the reasons Leading to the observed differences between the codes are also presented. This analyse shows a good agreement with the INCL4+ABLA code. (author)

  14. Cyclic Crack Growth Testing of an A.O. Smith Multilayer Pressure Vessel with Modal Acoustic Emission Monitoring and Data Assessment

    Science.gov (United States)

    Ziola, Steven M.

    2014-01-01

    Digital Wave Corp. (DWC) was retained by Jacobs ATOM at NASA Ames Research Center to perform cyclic pressure crack growth sensitivity testing on a multilayer pressure vessel instrumented with DWC's Modal Acoustic Emission (MAE) system, with captured wave analysis to be performed using DWCs WaveExplorerTM software, which has been used at Ames since 2001. The objectives were to document the ability to detect and characterize a known growing crack in such a vessel using only MAE, to establish the sensitivity of the equipment vs. crack size and / or relevance in a realistic field environment, and to obtain fracture toughness materials properties in follow up testing to enable accurate crack growth analysis. This report contains the results of the testing.

  15. Evaluación en campo de plantas de ñame (Dioscorea alata L. obtenidas de los microtubérculos formados en Sistema de Inmersión Temporal

    Directory of Open Access Journals (Sweden)

    Manuel Cabrera Jova

    2010-01-01

    Full Text Available Los microtubérculos en algunas especies de plantas constituyen una importante alternativa como material vegetal de plantación. Se definió como objetivo de trabajo evaluar en campo la respuesta morfoagronómica de las plantas obtenidas de los microtubérculos de ñame formados en Sistema de Inmersión Temporal (SIT. Como variantes experimentales se plantaron tres categorías de microtubérculos, clasificados según su masa fresca (I. de 0,5 a 0,9 g; II. de 1,0 a 2,9 g; III. igual o mayor de 3,0 g, plantas in vitro previamente aclimatadas y corona de tubérculo. Se evaluó el efecto de la masa fresca de los microtubérculos sobre su brote, supervivencia y posterior desarrollo de las plantas derivadas de ellos en campo. Con los microtubérculos de ñame, con una masa fresca igual o superior a 3,0 g, se alcanzó el más alto porcentaje de brotación (91,30% y supervivencia de las plantas (96,50%, así como las mejores respuestas en los caracteres cuantitativos que se evaluaron en campo. Estos resultados confirmaron la importancia de la masa fresca de los microtubérculos para ser empleados como material vegetal de plantación directo en campo.

  16. Shock-tunnel combustor testing for hypersonic vehicles

    Science.gov (United States)

    Loomis, Mark P.

    1994-01-01

    Proposed configurations for the next generation of transatmospheric vehicles will rely on air breathing propulsion systems during all or part of their mission. At flight Mach numbers greater than about 7 these engines will operate in the supersonic combustion ramjet mode (scramjet). Ground testing of these engine concepts above Mach 8 requires high pressure, high enthalpy facilities such as shock tunnels and expansion tubes. These impulse, or short duration facilities have test times on the order of a millisecond, requiring high speed instrumentation and data systems. One such facility ideally suited for scramjet testing is the NASA-Ames 16-Inch shock tunnel, which over the last two years has completed a series of tests for the NASP (National Aero-Space Plane) program at simulated flight Mach numbers ranging from 12-16. The focus of the experimental programs consisted of a series of classified tests involving a near-full scale hydrogen fueled scramjet combustor model in the semi-free jet method of engine testing whereby the compressed forebody flow ahead of the cowl inlet is reproduced (see appendix A). The AIMHYE-1 (Ames Integrated Modular Hypersonic Engine) test entry for the NASP program was completed in April 1993, while AIMHYE-2 was completed in May 1994. The test entries were regarded as successful, resulting in some of the first data of its kind on the performance of a near full scale scramjet engine at Mach 12-16. The data was distributed to NASP team members for use in design system verification and development. Due to the classified nature of the hardware and data, the data reports resulting from this work are classified and have been published as part of the NASP literature. However, an unclassified AIAA paper resulted from the work and has been included as appendix A. It contains an overview of the test program and a description of some of the important issues.

  17. Test Architecture, Test Retrofit

    Science.gov (United States)

    Fulcher, Glenn; Davidson, Fred

    2009-01-01

    Just like buildings, tests are designed and built for specific purposes, people, and uses. However, both buildings and tests grow and change over time as the needs of their users change. Sometimes, they are also both used for purposes other than those intended in the original designs. This paper explores architecture as a metaphor for language…

  18. Testing Significance Testing

    Directory of Open Access Journals (Sweden)

    Joachim I. Krueger

    2018-04-01

    Full Text Available The practice of Significance Testing (ST remains widespread in psychological science despite continual criticism of its flaws and abuses. Using simulation experiments, we address four concerns about ST and for two of these we compare ST’s performance with prominent alternatives. We find the following: First, the 'p' values delivered by ST predict the posterior probability of the tested hypothesis well under many research conditions. Second, low 'p' values support inductive inferences because they are most likely to occur when the tested hypothesis is false. Third, 'p' values track likelihood ratios without raising the uncertainties of relative inference. Fourth, 'p' values predict the replicability of research findings better than confidence intervals do. Given these results, we conclude that 'p' values may be used judiciously as a heuristic tool for inductive inference. Yet, 'p' values cannot bear the full burden of inference. We encourage researchers to be flexible in their selection and use of statistical methods.

  19. Multilayer Pressure Vessel Materials Testing and Analysis. Phase 1

    Science.gov (United States)

    Cardinal, Joseph W.; Popelar, Carl F.; Page, Richard A.

    2014-01-01

    To provide NASA a comprehensive suite of materials strength, fracture toughness and crack growth rate test results for use in remaining life calculations for aging multilayer pressure vessels, Southwest Research Institute (R) (SwRI) was contracted in two phases to obtain relevant material property data from a representative vessel. This report describes Phase 1 of this effort which includes a preliminary material property assessment as well as a fractographic, fracture mechanics and fatigue crack growth analyses of an induced flaw in the outer shell of a representative multilayer vessel that was subjected to cyclic pressure test. SwRI performed this Phase 1 effort under contract to the Digital Wave Corporation in support of their contract to Jacobs ATOM for the NASA Ames Research Center.

  20. Seismic testing

    International Nuclear Information System (INIS)

    Sollogoub, Pierre

    2001-01-01

    This lecture deals with: qualification methods for seismic testing; objectives of seismic testing; seismic testing standards including examples; main content of standard; testing means; and some important elements of seismic testing

  1. Schirmer test

    Science.gov (United States)

    Tear test; Tearing test; Dry eye test; Basal secretion test; Sjögren - Schirmer; Schirmer's test ... used when the eye doctor suspects you have dry eye. Symptoms include dryness of the eyes or excessive ...

  2. Pinworm test

    Science.gov (United States)

    Oxyuriasis test; Enterobiasis test; Tape test ... diagnose this infection is to do a tape test. The best time to do this is in ... lay their eggs at night. Steps for the test are: Firmly press the sticky side of a ...

  3. Ultrasonic Testing

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyeong Jun; Kuk, Jeong Han

    2002-02-15

    This book introduces ultrasonic testing, which tells of outline of ultrasonic testing, principle of ultrasonic testing, prosperities of ultrasonic waves, radiographic test and ultrasonic test, basic theory on ultrasonic testing, mode conversion, transmission and diffraction, ultrasonic flaw detection and probe, standard test piece and reference test piece, like KS(JIS) ASME and ASTM, classification and properties of ultrasonic testing, straight beam method, angle beam method, ASME SEC.V.Art.5 ASTMA 388 and KS B 0817 Korean industrial standard.

  4. Molecular characterisation of Colombian yam germplasm by "DNA amplification fingerprinting (DAF" in radioactivo conditions Caracterización molecular del germoplasma de ñame colombiano utilizando "DNA Amplificaron Fingerprinting (DAF" en condiciones radiactivas

    Directory of Open Access Journals (Sweden)

    Bustamante Silvia L.

    2003-12-01

    sustainability for small-scale Colombian yam farmers.Para la realización de este trabajo se utilizaron muestras de la colección de ñame (Dioscorea spp. de la Universi­dad de Córdoba y algunas muestras provenientes del IITA (International Institute of Tropical Agriculture, Ibadan, Nigeria, con el fin de caracterizarlas molecularmente y complementar la información que se tiene de ellas. Dada la importancia del cultivo del ñame para los pequeños productores de la costa atlántica, surgió la propuesta de iniciar estudios moleculares en una primera etapa empleando técnicas como los AFLP En este trabajo, utilizan­do DNA amplificación "fingerprinting" (DAF, técnica basada en la PCR que utiliza oligos aleatorios que gene­ran patrones de bandeo característicos de cada individuo, se encontró que la diversidad de la población fue 0.0413 con una media de similaridad de 0.9587, lo cual indica que la colección de ñame existente en el país posee muy poca diversidad genética, y esto puede explicar parcialmente la vulnerabilidad del cultivo a plagas y enfer­medades, como sucedió a finales de la década de 1980 cuando la antracnosis prácticamente acabó con el cultivo en la costa atlántica colombiana. Es recomendable continuar con los estudios de caracterización utilizando una técnica de mayor poder de discriminación.

  5. Ames Infusion Stories for NASA Annual Technology Report: Development of an Ablative 3D Quartz / Cyanate Ester Composite Multi-Functional Material for the Orion Spacecraft Compression Pad

    Science.gov (United States)

    Smith, Brandon; Jan, Darrell Leslie; Venkatapathy, Ethiraj

    2015-01-01

    Vehicles re-entering Earth's atmosphere require protection from the heat of atmospheric friction. The Orion Multi-Purpose Crew Vehicle (MPCV) has more demanding thermal protection system (TPS) requirements than the Low Earth Orbit (LEO) missions, especially in regions where the structural load passes through. The use of 2-dimensional laminate materials along with a metal insert, used in EFT1 flight test for the compression pad region, are deemed adequate but cannot be extended for Lunar return missions.

  6. Nano-ADEPT Aeroloads Wind Tunnel Test

    Science.gov (United States)

    Smith, Brandon; Yount, Bryan; Kruger, Carl; Brivkalns, Chad; Makino, Alberto; Cassell, Alan; Zarchi, Kerry; McDaniel, Ryan; Ross, James; Wercinski, Paul; hide

    2016-01-01

    A wind tunnel test of the Adaptable Deployable Entry and Placement Technology (ADEPT) was conducted in April 2015 at the US Army's 7 by10 Foot Wind Tunnel located at NASA Ames Research Center. Key geometric features of the fabric test article were a 0.7 meter deployed base diameter, a 70 degree half-angle forebody cone angle, eight ribs, and a nose-to-base radius ratio of 0.7. The primary objective of this wind tunnel test was to obtain static deflected shape and pressure distributions while varying pretension at dynamic pressures and angles of attack relevant to entry conditions at Earth, Mars, and Venus. Other objectives included obtaining aerodynamic force and moment data and determining the presence and magnitude of any dynamic aeroelastic behavior (buzz/flutter) in the fabric trailing edge. All instrumentation systems worked as planned and a rich data set was obtained. This paper describes the test articles, instrumentation systems, data products, and test results. Four notable conclusions are drawn. First, test data support adopting a pre-tension lower bound of 10 foot pounds per inch for Nano-ADEPT mission applications in order to minimize the impact of static deflection. Second, test results indicate that the fabric conditioning process needs to be reevaluated. Third, no flutter/buzz of the fabric was observed for any test condition and should also not occur at hypersonic speeds. Fourth, translating one of the gores caused ADEPT to generate lift without the need for a center of gravity offset. At hypersonic speeds, the lift generated by actuating ADEPT gores could be used for vehicle control.

  7. Caracterización molecular de Colletotrichum gloeosporioides aislado de plantas de ñame de la Costa Atlántica Colombiana utilizando la técnica “DNA Amplification Fingerprinting (DAF”

    Directory of Open Access Journals (Sweden)

    Natalia Giraldo Marroquín

    2016-01-01

    Full Text Available La antracnosis en ñame, causada por el hongo Colletotrichum gloeosporioides, es una enfermedad relevante que posee el potencial de destruir el 100% de la cosecha, convirtiéndose en la principal limitante fitosanitaria para el rendimiento del cultivo en el país. Esta es una situación preocupante considerando que aproximadamente 35.000 familias de pequeños y medianos agricultores de la Costa Atlántica Colombiana subsisten de este cultivo; es por esto que el objetivo de este trabajo fue caracterizar molecularmente 42 aislamientos del hongo procedentes de plantas de ñame con síntomas de la enfermedad, utilizando la técnica molecular “DNA Amplification Fingerprinting (DAF”, caracterizada por su resolución en la determinación de la variabilidad genética de diferentes organismos. Para la determinación de polimorfismos, se amplificaron 16 marcadores DAF implementando iniciadores tipo decámero, los cuales fueron visualizados por electroforesis en microchip con el equipo MCE-202 MultiNA. Se evaluó la reproducibilidad de la técnica DAF. La amplificación arrojó 391 bandas inequívocamente polimórficas en todas las muestras, el coeficiente de Dice identificó cinco grupos con 0.30% de similaridad y el índice de diversidad genética fue de 0.28; datos que reflejan un alto grado de variabilidad en la colección estudiada de C. gloeosporioides. Ésta puede deberse, al intercambio de germoplasma, a su condición heterotálica, a las mutaciones y al alto potencial de dispersión de las conidias que le permiten mantener la viabilidad bajo condiciones adversas. Por último, se encontró que DAF es una técnica reproducible, confirmando que es una metodología fiable para la caracterización molecular de hongos.

  8. The strains recommended for use in the bacterial reverse mutation test (OECD guideline 471) can be certified as non-genetically modified organisms.

    Science.gov (United States)

    Sugiyama, Kei-Ichi; Yamada, Masami; Awogi, Takumi; Hakura, Atsushi

    2016-01-01

    The bacterial reverse mutation test, commonly called Ames test, is used worldwide. In Japan, the genetically modified organisms (GMOs) are regulated under the Cartagena Domestic Law, and organisms obtained by self-cloning and/or natural occurrence would be exempted from the law case by case. The strains of Salmonella typhimurium and Escherichia coli recommended for use in the bacterial reverse mutation test (OECD guideline 471), have been considered as non-GMOs because they can be constructed by self-cloning or naturally occurring bacterial strains, or do not disturb the biological diversity. The present article explains the reasons why these tester strains should be classified as non-GMOs.

  9. Trichomonas Testing

    Science.gov (United States)

    ... Genetic Tests for Targeted Cancer Therapy Glucose Tests Gonorrhea Testing Gram Stain Growth Hormone Haptoglobin hCG Pregnancy ... With some NAATs, samples collected for testing of gonorrhea and chlamydial infections can also be used to ...

  10. Coombs test

    Science.gov (United States)

    Direct antiglobulin test; Indirect antiglobulin test; Anemia - hemolytic ... No special preparation is necessary for this test. ... There are 2 types of the Coombs test: Direct Indirect The direct ... that are stuck to the surface of red blood cells. Many diseases ...

  11. Ham test

    Science.gov (United States)

    Acid hemolysin test; Paroxysmal nocturnal hemoglobinuria - Ham test; PNH - Ham test ... BJ. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures . 6th ed. Philadelphia, PA: Elsevier ...

  12. Configuration management issues and objectives for a real-time research flight test support facility

    Science.gov (United States)

    Yergensen, Stephen; Rhea, Donald C.

    1988-01-01

    Presented are some of the critical issues and objectives pertaining to configuration management for the NASA Western Aeronautical Test Range (WATR) of Ames Research Center. The primary mission of the WATR is to provide a capability for the conduct of aeronautical research flight test through real-time processing and display, tracking, and communications systems. In providing this capability, the WATR must maintain and enforce a configuration management plan which is independent of, but complimentary to, various research flight test project configuration management systems. A primary WATR objective is the continued development of generic research flight test project support capability, wherein the reliability of WATR support provided to all project users is a constant priority. Therefore, the processing of configuration change requests for specific research flight test project requirements must be evaluated within a perspective that maintains this primary objective.

  13. Magnesium Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  14. Lipase Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  15. Rubella Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  16. Mono Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  17. AMA Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  18. One-fiftieth scale model studies of 40-by 80-foot and 80-by 120-foot wind tunnel complex at NASA Ames Research Center

    Science.gov (United States)

    Schmidt, Gene I.; Rossow, Vernon J.; Vanaken, Johannes M.; Parrish, Cynthia L.

    1987-01-01

    The features of a 1/50-scale model of the National Full-Scale Aerodynamics Complex are first described. An overview is then given of some results from the various tests conducted with the model to aid in the design of the full-scale facility. It was found that the model tunnel simulated accurately many of the operational characteristics of the full-scale circuits. Some characteristics predicted by the model were, however, noted to differ from previous full-scale results by about 10%.

  19. Field Tested Service Oriented Robotic Architecture: Case Study

    Science.gov (United States)

    Flueckiger, Lorenzo; Utz, Hanz

    2012-01-01

    This paper presents the lessons learned from six years of experiments with planetary rover prototypes running the Service Oriented Robotic Architecture (SORA) developed by the Intelligent Robotics Group (IRG) at NASA Ames Research Center. SORA relies on proven software methods and technologies applied to the robotic world. Based on a Service Oriented Architecture and robust middleware, SORA extends its reach beyond the on-board robot controller and supports the full suite of software tools used during mission scenarios from ground control to remote robotic sites. SORA has been field tested in numerous scenarios of robotic lunar and planetary exploration. The results of these high fidelity experiments are illustrated through concrete examples that have shown the benefits of using SORA as well as its limitations.

  20. Flight and full-scale wind-tunnel comparison of pressure distributions from an F-18 aircraft at high angles of attack. [Conducted in NASA Ames Research Center's 80 by 120 ft wind tunnel

    Science.gov (United States)

    Fisher, David F.; Lanser, Wendy R.

    1994-01-01

    Pressure distributions were obtained at nearly identical fuselage stations and wing chord butt lines in flight on the F-18 HARV at NASA Dryden Flight Research Center and in the NASA Ames Research Center's 80 by 120 ft wind tunnel on a full-scale F/A-18 aircraft. The static pressures were measured at the identical five stations on the forebody, three stations on the left and right leading-edge extensions, and three spanwise stations on the wing. Comparisons of the flight and wind-tunnel pressure distributions were made at alpha = 30 deg, 45 deg, and 60 deg/59 deg. In general, very good agreement was found. Minor differences were noted at the forebody at alpha = 45 deg and 60 deg in the magnitude of the vortex footprints and a Mach number effect was noted at the leading-edge extension at alpha = 30 deg. The inboard leading edge flap data from the wind tunnel at alpha = 59 deg showed a suction peak that did not appear in the flight data. This was the result of a vortex from the corner of the leading edge flap whose path was altered by the lack of an engine simulation in the wind tunnel.

  1. An automated, open-source (NASA Ames Stereo Pipeline) workflow for mass production of high-resolution DEMs from commercial stereo satellite imagery: Application to mountain glacies in the contiguous US

    Science.gov (United States)

    Shean, D. E.; Arendt, A. A.; Whorton, E.; Riedel, J. L.; O'Neel, S.; Fountain, A. G.; Joughin, I. R.

    2016-12-01

    We adapted the open source NASA Ames Stereo Pipeline (ASP) to generate digital elevation models (DEMs) and orthoimages from very-high-resolution (VHR) commercial imagery of the Earth. These modifications include support for rigorous and rational polynomial coefficient (RPC) sensor models, sensor geometry correction, bundle adjustment, point cloud co-registration, and significant improvements to the ASP code base. We outline an automated processing workflow for 0.5 m GSD DigitalGlobe WorldView-1/2/3 and GeoEye-1 along-track and cross-track stereo image data. Output DEM products are posted at 2, 8, and 32 m with direct geolocation accuracy of process individual stereo pairs on a local workstation, the methods presented here were developed for large-scale batch processing in a high-performance computing environment. We have leveraged these resources to produce dense time series and regional mosaics for the Earth's ice sheets. We are now processing and analyzing all available 2008-2016 commercial stereo DEMs over glaciers and perennial snowfields in the contiguous US. We are using these records to study long-term, interannual, and seasonal volume change and glacier mass balance. This analysis will provide a new assessment of regional climate change, and will offer basin-scale analyses of snowpack evolution and snow/ice melt runoff for water resource applications.

  2. Neuropathy Tests

    Science.gov (United States)

    ... LD) Lactoferrin Lactose Tolerance Tests LDL Cholesterol LDL Particle Testing (LDL-P) Lead Legionella Testing Leptin Levetiracetam Lipase ... tests, such as computed tomography (CT) scans or magnetic resonance imaging ... suspected, additional testing may be performed to evaluate heart rate, blood ...

  3. Mutagenicity of fly ash samples in a test with the protozoan Paramecium tetraurelia. Onderzoek naar de mutageniteit van een aantal vliegasmonsters in een toets met het pantoffeldiertje Paramecium tetraurelia

    Energy Technology Data Exchange (ETDEWEB)

    Hooftman, R.N.

    1983-08-01

    The mutagenicity of fly ash derived from combustion of coal was investigated in a test with the protozoan Paramecium tetraurelia. This unicellular organism is able to ingest particles of the size of these that are ingested and removed by the alveolar macrophages in the lung of man and other animals: in Paramecium, as in the macrophage, ingestion is followed by intracellular extraction. Both ash from the electrostatic filter and stack-ash were mutagenic in Paramecium. The results showed similarities with and some differences from those obtained in the Ames test. There are indications that the test with Paramecium is a sensitive test for the mutagenicity of complex wastes.

  4. Mutagenicity of fly ash samples in a test with the protozoan Paramecium tetraurelia. Onderzoek naar de mutageniteit van een aantal vliegasmonsters in een toets met het pantoffeldiertje Paramecium tetraurelia

    Energy Technology Data Exchange (ETDEWEB)

    Hooftman, R.N.

    1983-08-01

    The mutagenicity of fly ash derived from combustion of coal was investigated in a test with the protozoan Paramecium tetraurelia. This unicellular organism is able to ingest particles of the size of those that are ingested and removed by the alveolar macrophages in the lung of man and other animals: in Paramecium, as in the macrophage, ingestion is followed by intracellular extraction. Both ash from the electrostatic filter and stack-ash were mutagenic in Paramecium. The results showed similarities with and some differences from those obtained in the Ames test. There are indications that the test with Paramecium is a sensitive test for the mutagenicity of complex wastes.

  5. Preclinical test: bacterial reverse mutation test for {sup 18}F-fluorocholine produced in CDTN

    Energy Technology Data Exchange (ETDEWEB)

    Mendes, Bruno M.; Bispo, Ana Carolina A.; Campos, Danielle C.; Silva, Juliana B., E-mail: bmm@cdtn.br, E-mail: acab@cdtn.br, E-mail: dcc@cdtn.br, E-mail: silvajb@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2013-07-01

    The choline labeled with fluorine-18 (18FCH) is being considered as a great importance radiopharmaceutical due to its effective detection of many type of malignant neoplasm. The research related to {sup 18}F-fluorocholine synthesis in CDTN was initiated in 2010. In order to obtain clinical research approval, as well as to register {sup 18}FCH for marketing, safety and efficacy preclinical testing are required. The present work evaluated the {sup 18}FCH genotoxic potential through the bacterial reverse mutation test (Ames test) using Salmonella typhimurium TA-98, TA-100, TA-1535 and TA-1537 strains and Escherichia coli WP2 uvrA strain. The reverse mutation test in bacteria for fluorcolina was conducted in two stages. Initially the method was applied to 'cold' fluorocholine molecule (19FCH). Subsequently, the decayed product of {sup 18}FCH synthesis was evaluated. The first step was performed in order to examine the FCH molecule mutagenicity. The second was carried out to determine the mutagenic potential of final product. All strains were tested in triplicate for each exposure concentration, in the presence and absence of metabolic activation (S-9 mix - 10%). There were no statistically significant increases in revertant colonies rate for any strains tested after their exposure to decayed {sup 18}FCH or {sup 19}FCH. The number of revertant colonies in positive controls was significantly higher than that observed in significant increases in revertant colonies rate for any strains tested after their exposure to decayed {sup 18}FCH or {sup 19}FCH. The number of revertant colonies in positive controls was significantly higher than that observed in negative controls. Based on results of this assay, {sup 18}FCH and {sup 19}FCH, at tested doses, were found to be non-mutagenic in bacterial reverse mutation test. (author)

  6. Preclinical test: bacterial reverse mutation test for 18F-fluorocholine produced in CDTN

    International Nuclear Information System (INIS)

    Mendes, Bruno M.; Bispo, Ana Carolina A.; Campos, Danielle C.; Silva, Juliana B.

    2013-01-01

    The choline labeled with fluorine-18 (18FCH) is being considered as a great importance radiopharmaceutical due to its effective detection of many type of malignant neoplasm. The research related to 18 F-fluorocholine synthesis in CDTN was initiated in 2010. In order to obtain clinical research approval, as well as to register 18 FCH for marketing, safety and efficacy preclinical testing are required. The present work evaluated the 18 FCH genotoxic potential through the bacterial reverse mutation test (Ames test) using Salmonella typhimurium TA-98, TA-100, TA-1535 and TA-1537 strains and Escherichia coli WP2 uvrA strain. The reverse mutation test in bacteria for fluorcolina was conducted in two stages. Initially the method was applied to 'cold' fluorocholine molecule (19FCH). Subsequently, the decayed product of 18 FCH synthesis was evaluated. The first step was performed in order to examine the FCH molecule mutagenicity. The second was carried out to determine the mutagenic potential of final product. All strains were tested in triplicate for each exposure concentration, in the presence and absence of metabolic activation (S-9 mix - 10%). There were no statistically significant increases in revertant colonies rate for any strains tested after their exposure to decayed 18 FCH or 19 FCH. The number of revertant colonies in positive controls was significantly higher than that observed in significant increases in revertant colonies rate for any strains tested after their exposure to decayed 18 FCH or 19 FCH. The number of revertant colonies in positive controls was significantly higher than that observed in negative controls. Based on results of this assay, 18 FCH and 19 FCH, at tested doses, were found to be non-mutagenic in bacterial reverse mutation test. (author)

  7. Validation of US3D for Capsule Aerodynamics using 05-CA Wind Tunnel Test Data

    Science.gov (United States)

    Schwing, Alan

    2012-01-01

    Several comparisons of computational fluid dynamics to wind tunnel test data are shown for the purpose of code validation. The wind tunnel test, 05-CA, uses a 7.66% model of NASA's Multi-Purpose Crew Vehicle in the 11-foot test section of the Ames Unitary Plan Wind tunnel. A variety of freestream conditions over four Mach numbers and three angles of attack are considered. Test data comparisons include time-averaged integrated forces and moments, time-averaged static pressure ports on the surface, and Strouhal Number. The applicability of the US3D code to subsonic and transonic flow over a bluff body is assessed on a comprehensive data set. With close comparison, this work validates US3D for highly separated flows similar to those examined here.

  8. NASA-FAA helicopter Microwave Landing System curved path flight test

    Science.gov (United States)

    Swenson, H. N.; Hamlin, J. R.; Wilson, G. W.

    1984-01-01

    An ongoing series of joint NASA/FAA helicopter Microwave Landing System (MLS) flight tests was conducted at Ames Research Center. This paper deals with tests done from the spring through the fall of 1983. This flight test investigated and developed solutions to the problem of manually flying curved-path and steep glide slope approaches into the terminal area using the MLS and flight director guidance. An MLS-equipped Bell UH-1H helicopter flown by NASA test pilots was used to develop approaches and procedures for flying these approaches. The approaches took the form of Straight-in, U-turn, and S-turn flightpaths with glide slopes of 6 deg, 9 deg, and 12 deg. These procedures were evaluated by 18 pilots from various elements of the helicopter community, flying a total of 221 hooded instrument approaches. Flying these curved path and steep glide slopes was found to be operationally acceptable with flight director guidance using the MLS.

  9. Wind Tunnel and Hover Performance Test Results for Multicopter UAS Vehicles

    Science.gov (United States)

    Russell, Carl R.; Jung, Jaewoo; Willink, Gina; Glasner, Brett

    2016-01-01

    There is currently a lack of published data for the performance of multicopter unmanned aircraft system (UAS) vehicles, such as quadcopters and octocopters, often referred to collectively as drones. With the rapidly increasing popularity of multicopter UAS, there is interest in better characterizing the performance of this type of aircraft. By studying the performance of currently available vehicles, it will be possible to develop models for vehicles at this scale that can accurately predict performance and model trajectories. This paper describes a wind tunnel test that was recently performed in the U.S. Army's 7- by 10-ft Wind Tunnel at NASA Ames Research Center. During this wind tunnel entry, five multicopter UAS vehicles were tested to determine forces and moments as well as electrical power as a function of wind speed, rotor speed, and vehicle attitude. The test is described here in detail, and a selection of the key results from the test is presented.

  10. Pharmacogenomic Testing

    Science.gov (United States)

    ... your family Plan for the future Insurance and financial planning Transition for children Emergency preparedness Testing & Services Testing ... Support Genetic Disease Information Find a Support Group Financial Planning Who Should I Tell? Genetic Testing & Counseling Compensation ...

  11. Predictive Testing

    Science.gov (United States)

    ... your family Plan for the future Insurance and financial planning Transition for children Emergency preparedness Testing & Services Testing ... Support Genetic Disease Information Find a Support Group Financial Planning Who Should I Tell? Genetic Testing & Counseling Compensation ...

  12. Syphilis Test

    Science.gov (United States)

    ... Genetic Tests for Targeted Cancer Therapy Glucose Tests Gonorrhea Testing Gram Stain Growth Hormone Haptoglobin hCG Pregnancy ... treated for another sexually transmitted disease , such as gonorrhea Is pregnant, during the first prenatal visit and ...

  13. Randomization tests

    CERN Document Server

    Edgington, Eugene

    2007-01-01

    Statistical Tests That Do Not Require Random Sampling Randomization Tests Numerical Examples Randomization Tests and Nonrandom Samples The Prevalence of Nonrandom Samples in Experiments The Irrelevance of Random Samples for the Typical Experiment Generalizing from Nonrandom Samples Intelligibility Respect for the Validity of Randomization Tests Versatility Practicality Precursors of Randomization Tests Other Applications of Permutation Tests Questions and Exercises Notes References Randomized Experiments Unique Benefits of Experiments Experimentation without Mani

  14. Testing, comparison, further development and assessment of genotoxicity tests for surface water. Findings of a BMBF study; Erprobung, Vergleich, Weiterentwicklung und Beurteilung von Gentoxizitaetstests fuer Oberflaechenwasser. Ergebnisse eines BMBF-Verbundvorhabens

    Energy Technology Data Exchange (ETDEWEB)

    Grummt, T. [Umweltbundesamt, Bad Elster (Germany)

    2001-05-01

    A research project was designed to develop a test strategy for the detection and evaluation of genotoxic effects in surface water aquatic organisms. Indicator tests were evaluated with respect to their predictive power, sensitivity and practicability in order to determine whether they are suitable for inclusion in a battery of tests. The bioassays utilized in this study include the umu-test, alkaline filter elution (mussels, green algae), the DNA unwinding test (fish larvae, cray fish, mussels, fish cell lines), the comet assay (protozoans, green algae, mussels, primary fish hepatocytes, fish and mammalian cell lines) and the UDS-test (primary fish hepatocytes). The Ames Salmonella assay, a direct genotoxicity assay and a well-known base test in chemicals assessment, was included in the study programme for comparison. All test results were verified with statistical methods. During the first phase of the project five known genotoxic substances (2-acetylamidofluorene, benzo(a)pyrene, N-nitrosodimethylamine, nitrofurantoin, 4-nitroquinoin-N-oxide) were tested to establish and optimize the assays. In a second phase of the project the validated methods were applied to non-concentrated samples of surface water taken on a monthly basis from the river Rhine, the Wahnbach dam, the rivers Elbe and Mulde over a period of 12 months. The data obtained showed the comet assay, the umu-test and the Ames-test to be particularly sensitive and to detect genotoxic effects in complex mixtures in a low dose range. They seem to be suitable for routine testing and should therefore be used in the first stage of a graduated testing battery for detection of genotoxicity in surface water in combination with effect-oriented chemical analysis. (orig.)

  15. Population-based Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis Prevalence Using Discarded, Deidentified Urine Specimens Previously Collected for Drug Testing (Open Access Publisher’s Version)

    Science.gov (United States)

    2017-10-24

    trichomonas vaginalis testing, Melinda Balansay-ames, chris Myers and gary Brice for Pcr- based sex determination testing, and Kimberly De Vera for...2017-053355 rEFErEnCEs 1 torrone e , Papp J, Weinstock H. centers for Disease control and Prevention (cDc). Prevalence of Chlamydia trachomatis genital...infection among persons aged 14-39 years-United States, 2007-2012. MMWR Morb Mortal Wkly Rep 2014;63:834–7. 2 rietmeijer ca, Hopkins e , geisler WM

  16. Test chamber

    NARCIS (Netherlands)

    Leferink, Frank Bernardus Johannes

    2009-01-01

    A test chamber for measuring electromagnetic radiation emitted by an apparatus to be tested or for exposing an apparatus to be tested to an electromagnetic radiation field. The test chamber includes a reverberation chamber made of a conductive tent fabric. To create a statistically uniform field in

  17. MULTIPLICACIÓN Y TUBERIZACIÓN in vitro DE ÑAME (Dioscorea alata L. EN SISTEMA DE INMERSIÓN TEMPORAL MULTIPLICATION AND in vitro TUBERIZATION OF YAM (Dioscorea alata L. IN TEMPORARY IMMERSION SYSTEM

    Directory of Open Access Journals (Sweden)

    Robinson Salazar Díaz

    2007-12-01

    Full Text Available Se realizó la estandarización de la multiplicación y tuberización in vitro de ñame (Dioscorea alata L. utilizando el sistema de inmersión temporal conocido como RITA®. Se evaluó inicialmente el porcentaje de brotación de segmentos nodales en medio de cultivo semisólido utilizando dos tipos de citoquininas (BAP y Kinetina. Las plantas obtenidas fueron subcultivadas cada cuatro semanas y luego utilizadas para la obtención de meristemos y plántulas para llevar a cabo los diferentes experimentos en sistema de inmersión temporal. Se obtuvo un mayor porcentaje de explantes brotados al utilizar Kinetina. Con el sistema RITA® se evaluó el efecto de la densidad de explantes sobre la tasa de multiplicación y sobre la inducción, formación y desarrollo de microtubérculos, no encontrándose diferencias estadísticamente significativas entre las densidades evaluadas. De igual manera, se evaluó el efecto de diferentes frecuencias y tiempos de inmersión sobre la tasa de multiplicación, encontrándose que a una frecuencia de inmersión cada 12 horas y durante 10 minutos se obtenía la formación de mayor número de nudos y mayor tamaño de las plantas a las cuatro semanas de cultivo. Al utilizar el sistema de inmersión temporal se alcanzaron mayores tasas de multiplicación y tuberización in vitro comparadas con el sistema de cultivo convencional. Demostrándose así, el potencial de estos sistemas para implementar un programa de producción de semillas de ñame.Multiplication rate and in vitro tuberización of yam (Dioscorea alata L. was made using the temporary immersion system RITA®. Shoot percentage of nodal segments was initially evaluated in semisolid medium using two cytokinin types ((BAP and Kinetin. The obtained plants were subcultured every four weeks and then used to obtain meristems and plantlets to carry out different experiments in temporary immersion system. A higher sprouted explants percentage was obtained when using

  18. New and emerging technologies for genetic toxicity testing.

    Science.gov (United States)

    Lynch, Anthony M; Sasaki, Jennifer C; Elespuru, Rosalie; Jacobson-Kram, David; Thybaud, Véronique; De Boeck, Marlies; Aardema, Marilyn J; Aubrecht, Jiri; Benz, R Daniel; Dertinger, Stephen D; Douglas, George R; White, Paul A; Escobar, Patricia A; Fornace, Albert; Honma, Masamitsu; Naven, Russell T; Rusling, James F; Schiestl, Robert H; Walmsley, Richard M; Yamamura, Eiji; van Benthem, Jan; Kim, James H

    2011-04-01

    The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in genetic toxicology testing. The aim of the workgroup was to identify promising technologies that will improve genotoxicity testing and assessment of in vivo hazard and risk, and that have the potential to help meet the objectives of the IVGT. As part of this initiative, HESI convened a workshop in Washington, DC in May 2008 to discuss mature, maturing, and emerging technologies in genetic toxicology. This article collates the abstracts of the New and Emerging Technologies Workshop together with some additional technologies subsequently considered by the workgroup. Each abstract (available in the online version of the article) includes a section addressed specifically to the strengths, weaknesses, opportunities, and threats associated with the respective technology. Importantly, an overview of the technologies and an indication of how their use might be aligned with the objectives of IVGT are presented. In particular, consideration was given with regard to follow-up testing of positive results in the standard IVGT tests (i.e., Salmonella Ames test, chromosome aberration assay, and mouse lymphoma assay) to add weight of evidence and/or provide mechanism of action for improved genetic toxicity risk assessments in humans. Copyright © 2010 Wiley-Liss, Inc.

  19. Diversidad genética intra e inter-específica de ñame (Dioscorea spp. de la región Caribe de Colombia mediante marcadores AFLP

    Directory of Open Access Journals (Sweden)

    Hernando Javier Rivera-Jiménez

    2011-12-01

    Full Text Available Conocer la variabilidad genética del ñame, Dioscorea spp., permite apoyar estrategias de mejoramiento y conservación de este recurso fitogenético. El objetivo de este estudio fue la caracterización molecular de 20 accesiones de Dioscorea spp. mediante la técnica molecular de AFLP para determinar cómo se distribuye la variabilidad genética de manera intra e inter-específica. Los datos fueron analizados mediante los métodos de agrupación de correspondencia múltiple y análisis de similaridad de Dice, estableciendo los niveles de confiabilidad de los grupos genéticos mediante remuestreos. En términos de diversidad interespecífica, los valores promedios de similitud variaron entre 41.81% entre D. alata L. y D. rotundata Poir., y 33.51% entre D. trifida L.f. y D. esculenta (Lour. Burkill, lo que sugiere alta diversidad genética entre las accesiones estudiadas, que formaron cuatro grupos genéticos: D. alata, D. rotundata, D. esculenta y D. trifida, confirmando correspondencia entre la caracterización morfológica, clasificación botánica y la caracterización molecular. En términos de diversidad intraespecífica para la especie D. alata, el análisis también reveló una composición heterogénea en la región Caribe colombiana. Estos estudios ayudarán a definir una estrategia adecuada para fines de conservación y apoyar los esfuerzos futuros en los programas de mejoramiento genético.

  20. Final report, Ames Mobile Laboratory Project: The development and operation of instrumentation in a mobile laboratory for in situ, real-time screening and characterization of soils using the laser ablation sampling technique

    International Nuclear Information System (INIS)

    Anderson, M.S.; Braymen, S.D.

    1995-01-01

    The main focus of the Ames Laboratory's Technology Integration Program, TIP, from May 1991 through December 1994 was the development, fabrication, and demonstration of a mobile instrumentation laboratory incorporating rapid in situ sampling systems for safe, rapid, and cost effective soil screening/characterization. The Mobile Demonstration Laboratory for Environmental Screening Technologies, MDLEST, containing the analysis instrumentation, along with surface and subsurface sampling probe prototypes employing the laser ablation sampling technique were chosen to satisfy the particular surface and subsurface soil characterization needs of the various Department of Energy facilities for determining the extent of heavy metal and radionuclide contamination. The MDLEST, a 44 foot long 5th wheel trailer, is easily configured for the analysis instrumentation and sampling system required for the particular site work. This mobile laboratory contains all of the utilities needed to satisfy the operating requirements of the various instrumentation installed. These utilities include, an electric generator, a chilled water system, process gases, a heating/air conditioning system, and computer monitoring and automatic operating systems. Once the MDLEST arrives at the job site, the instrumentation is aligned and calibration is completed, sampling and analysis operations begin. The sample is acquired, analyzed and the results reported in as little as 10 minutes. The surface sampling probe is used in two modes to acquire samples for analysis. It is either set directly on the ground over the site to be sampled, in situ sampling, or in a special fixture used for calibrating the sampling analysis system with standard soil samples, having the samples brought to the MDLEST. The surface sampling probe was used to in situ sample a flat concrete surface (nondestructively) with the ablated sample being analyzed by the instrumentation in the MDLEST

  1. Tensile testing

    CERN Document Server

    2004-01-01

    A complete guide to the uniaxial tensile test, the cornerstone test for determining the mechanical properties of materials: Learn ways to predict material behavior through tensile testing. Learn how to test metals, alloys, composites, ceramics, and plastics to determine strength, ductility and elastic/plastic deformation. A must for laboratory managers, technicians, materials and design engineers, and students involved with uniaxial tensile testing. Tensile Testing , Second Edition begins with an introduction and overview of the test, with clear explanations of how materials properties are determined from test results. Subsequent sections illustrate how knowledge gained through tensile tests, such as tension properties to predict the behavior (including strength, ductility, elastic or plastic deformation, tensile and yield strengths) have resulted in improvements in materals applications. The Second Edition is completely revised and updated. It includes expanded coverage throughout the volume on a variety of ...

  2. Tests of Full-Scale Helicopter Rotors at High Advancing Tip Mach Numbers and Advance Ratios

    Science.gov (United States)

    Biggers, James C.; McCloud, John L., III; Stroub, Robert H.

    2015-01-01

    As a continuation of the studies of reference 1, three full-scale helicopter rotors have been tested in the Ames Research Center 40- by SO-foot wind tunnel. All three of them were two-bladed, teetering rotors. One of the rotors incorporated the NACA 0012 airfoil section over the entire length of the blade. This rotor was tested at advance ratios up to 1.05. Both of the other rotors were tapered in thickness and incorporated leading-edge camber over the outer 20 percent of the blade radius. The larger of these rotors was tested at advancing tip Mach numbers up to 1.02. Data were obtained for a wide range of lift and propulsive force, and are presented without discussion.

  3. NASA UAS Traffic Management National Campaign Operations across Six UAS Test Sites

    Science.gov (United States)

    Rios, Joseph; Mulfinger, Daniel; Homola, Jeff; Venkatesan, Priya

    2016-01-01

    NASA's Unmanned Aircraft Systems Traffic Management research aims to develop policies, procedures, requirements, and other artifacts to inform the implementation of a future system that enables small drones to access the low altitude airspace. In this endeavor, NASA conducted a geographically diverse flight test in conjunction with the FAA's six unmanned aircraft systems Test Sites. A control center at NASA Ames Research Center autonomously managed the airspace for all participants in eight states as they flew operations (both real and simulated). The system allowed for common situational awareness across all stakeholders, kept traffic procedurally separated, offered messages to inform the participants of activity relevant to their operations. Over the 3- hour test, 102 flight operations connected to the central research platform with 17 different vehicle types and 8 distinct software client implementations while seamlessly interacting with simulated traffic.

  4. Testing of a Wireless Sensor System for Instrumented Thermal Protection Systems

    Science.gov (United States)

    Kummer, Allen T.; Weir, Erik D.; Morris, Trey J.; Friedenberger, Corey W.; Singh, Aseem; Capuro, Robert M.; Bilen, Sven G.; Fu, Johnny; Swanson, Gregory T.; Hash, David B.

    2011-01-01

    Funded by NASA's Constellation Universities Institutes Project (CUIP), we have been developing and testing a system to wirelessly power and collect data from sensors on space platforms in general and, in particular, the harsh environment of spacecraft re-entry. The elimination of wires and associated failures such as chafing, sparking, ageing, and connector issues can increase reliability and design flexibility while reducing costs. These factors present an appealing case for the pursuit of wireless solutions for harsh environments, particularly for their use in space and on spacecraft. We have designed and built a prototype wireless sensor system. The system, with capabilities similar to that of a wired sensor system, was tested in NASA Ames Research Center s Aerodynamic Heating Facility and Interaction Heating Facility. This paper discusses the overall development effort, testing results, as well as future directions.

  5. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol

    International Nuclear Information System (INIS)

    Dunkel, V.C.; Zeiger, E.; Brusick, D.; McCoy, E.; McGregor, D.; Mortelmans, K.; Rosenkranz, H.S.; Simmon, V.F.

    1984-01-01

    The Salmonella/microsome test developed by Ames and his coworkers has been widely used in the evaluation of chemicals for genotoxic potential. Although the value of this assay is well recognized, there have been no comprehensive studies on the interlaboratory reproducibility of the method using a standardized protocol. A program was therefore initiated to compare the results obtained in four laboratories from testing a series of coded mutagens and nonmutagens using a standardized protocol. Additional objectives of this study were to compare male Fisher 344 rat, B6C3F1 mouse, and Syrian hamster liver S-9 preparations for the activation of chemicals; to compare Aroclor 1254-induced liver S-9 from all three species with the corresponding non-induced liver S-9's; and to compare the response of Escherichia coli WP-2 uvrA with the Salmonella typhimurium tester strains recommended by Ames. Since a primary use of in vitro microbial mutagenesis tests is the identification of potential carcinogens by their mutagenicity, the authors decided to compare the animal species and strains used by the National Cancer Institute/National Toxicology Program (NCI/NTP) for animal carcinogenicity studies

  6. Test quality

    International Nuclear Information System (INIS)

    Hartley, R.S.; Keller, A.E.

    1992-01-01

    Inservice testing of safety-related components at nuclear power plants is performed under the American Society of Mechanical Engineers Boiler and Pressure Vessel Code (the Code). Subsections IWP and IWV of Section 11 of the Code state test method and frequency requirements for pumps and valves, respectively. Tests vary greatly in quality and frequency. This paper explores the concept of test quality and its relationship with operational readiness and preventive maintenance. This paper also considers the frequencies of component testing. Test quality is related to a test's ability to detect degradation that can cause component failure. The quality of the test depends on several factors, including specific parameters measured, system or component conditions, and instrument accuracy. The quality of some currently required tests for check valves, motor-operated valves, and pumps is also discussed. Suggestions are made to improve test quality by measuring different parameters, testing valves under load, and testing positive displacement pumps at high pressure and centrifugal pumps at high flow rate conditions. These suggestions can help to improve the level of assurance of component operational readiness gained from testing

  7. Test quality

    International Nuclear Information System (INIS)

    Hartley, R.S.; Keller, A.E.

    1992-01-01

    This document discusses inservice testing of safety-related components at nuclear power plants which is performed under the American Society of Mechanical Engineers Boiler and Pressure Vessel Code (the Code). Subsections IWP and IWV of Section XI of the Code state test method and frequency requirements for pumps and valves respectively. Tests vary greatly in quality and frequency. This paper explores the concept of test quality and its relationship with operational readiness and preventive maintenance. This paper also considers the frequencies of component testing. Test quality is related to a test's ability to detect degradation that can cause component failure. The quality of the test depends on several factors, including specific parameters measured, system or component conditions, and instrument accuracy. The quality of some currently required tests for check valves, motor-operated valves, and pumps is also discussed. Suggestions are made to improve test quality by measuring different parameters, testing valves under load, and testing positive displacement pumps at high pressure and centrifugal pumps at high flow rate conditions. These suggestions can help to improve the level of assurance of component operational readiness gained from testing

  8. Randomization tests

    National Research Council Canada - National Science Library

    Edgington, Eugene S

    1980-01-01

    .... This book provides all the necessary theory and practical guidelines, such as instructions for writing computer programs, to permit experimenters to transform any statistical test into a distribution-free test...

  9. Laboratory Tests

    Science.gov (United States)

    ... Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & ... What are lab tests? Laboratory tests are medical devices that are intended for use on samples of blood, urine, or other tissues ...

  10. Triglycerides Test

    Science.gov (United States)

    ... K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2 nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Triglycerides; 491–2 p. Lab Tests ...

  11. Lactate Test

    Science.gov (United States)

    ... Plasma Free Metanephrines Platelet Count Platelet Function Tests Pleural Fluid Analysis PML-RARA Porphyrin Tests Potassium Prealbumin ... ency/article/000391.htm . (2002 January, Updated). Lactate (Liquid) Reagent Set. Pointe Scientific, Inc. [On-line Reagent ...

  12. Electrolytes Test

    Science.gov (United States)

    ... Plasma Free Metanephrines Platelet Count Platelet Function Tests Pleural Fluid Analysis PML-RARA Porphyrin Tests Potassium Prealbumin ... of potassium is found in the plasma , the liquid portion of the blood. Monitoring potassium is important ...

  13. Ferritin Test

    Science.gov (United States)

    ... normal" values. By comparing your test results with reference values, you and your healthcare provider can see if ... along with other iron tests , when a routine complete blood count (CBC) shows that a person's hemoglobin and hematocrit ...

  14. Cholesterol Test

    Science.gov (United States)

    ... artery disease. Other names for a cholesterol test: Lipid profile, Lipid panel What is it used for? If you ... Clinic [Internet]. Mayo Foundation for Medical Education and Research; c1998-2017.Cholesterol Test: Overview; 2016 Jan 12 [ ...

  15. Gonorrhea Test

    Science.gov (United States)

    ... Links Patient Resources For Health Professionals Subscribe Search Gonorrhea Testing Send Us Your Feedback Choose Topic At ... Sources Ask Us Also Known As GC Test Gonorrhea NAAT or NAT Neisseria gonorrhoeae Nucleic Acid Amplification ...

  16. Susceptibility Testing

    Science.gov (United States)

    ... Marker Bicarbonate (Total CO2) Bilirubin Blood Culture Blood Gases Blood Ketones Blood Smear Blood Typing Blood Urea ... hours depending on the method used. There are commercial tests available that offer rapid susceptibility testing and ...

  17. Nationale test

    DEFF Research Database (Denmark)

    2009-01-01

    Professor Sven Erik Nordenbo og centerleder Niels Egelund, begge DPU, i samtale om nationale test.......Professor Sven Erik Nordenbo og centerleder Niels Egelund, begge DPU, i samtale om nationale test....

  18. Nationale Test

    DEFF Research Database (Denmark)

    2009-01-01

    Hvad er egentlig formålet med de nationale test? Bliver eleverne klogere af at blive testet? Og er der en sammenhæng mellem bandekrig og nationale test? Fysisk medie: dpu.dk/tv......Hvad er egentlig formålet med de nationale test? Bliver eleverne klogere af at blive testet? Og er der en sammenhæng mellem bandekrig og nationale test? Fysisk medie: dpu.dk/tv...

  19. VDRL test

    Science.gov (United States)

    ... confirmed with another blood test to make the diagnosis of syphilis. Normal value ranges may vary slightly among different ... broken) Alternative Names Venereal disease research ... laboratory test (VDRL) – serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures . 6th ed. St Louis, MO: Elsevier Saunders; ...

  20. Drug Testing

    Science.gov (United States)

    ... testing, substance abuse testing, toxicology screen, tox screen, sports doping tests What is it used for? Drug screening is used to find out whether or not a person has taken a certain drug or drugs. It ... Sports organizations. Professional and collegiate athletes usually need to ...

  1. HIV Testing

    Science.gov (United States)

    ... Abroad Treatment Basic Statistics Get Tested Find an HIV testing site near you. Enter ZIP code or city Follow HIV/AIDS CDC HIV CDC HIV/AIDS See RSS | ... All Collapse All Should I get tested for HIV? CDC recommends that everyone between the ages of ...

  2. Nondestructive Testing

    Energy Technology Data Exchange (ETDEWEB)

    Berger, Harold [Argonne National Laboratory

    1969-01-01

    A nondestructive test is an examination of an object in any manner which will not impair the future usefulness of the object. This booklet discusses a few basic methods of nondestructive testing, and some of their characteristics. In addition, it discusses possible future methods for nondestructive testing by taking a quick look at some of the methods now under study.

  3. J ames Clerk Maxwell and his Equations

    Indian Academy of Sciences (India)

    standing importance in the development of physical ideas. Maxwell has been ... mathematics teacher was William Hopkins, the famous 'Wran- ... union (like Faraday's) was child- ... bility or to use any influence when he unsuccessfully tried for.

  4. Diversidad genética intra e inter-específica de ñame (Dioscorea spp. de la región Caribe de Colombia mediante marcadores AFLP

    Directory of Open Access Journals (Sweden)

    Alvarez Soto Andres

    2011-12-01

    Full Text Available Conocer la variabilidad genética del ñameDioscorea spp., permite apoyar estrategias de mejoramiento y conservación de este recurso fitogenético. El objetivo de este estudio fue la caracterización molecular de 20 accesiones de Dioscorea spp. mediante la técnica molecular de AFLP para determinar cómo se distribuye la variabilidad genética de manera intra e inter-específica. Los datos fueron analizados mediante los métodos de agrupación de correspondencia múltiple y análisis de similaridad de Dice, estableciendo los niveles de confiabilidad de los grupos genéticos mediante remuestreos. En términos de diversidad interespecífica, los valores promedios de similitud variaron entre 41.81% entre D. alata L. y D. rotundata Poir., y 33.51% entre D. trifida L.f. y D. esculenta (Lour. Burkill, lo que sugiere alta diversidad genética entre las accesiones estudiadas, que formaron cuatro grupos genéticos: D. alataD. rotundataD. esculenta y D. trifida, confirmando correspondencia entre la caracterización morfológica, clasificación botánica y la caracterización molecular. En términos de diversidad intraespecífica para la especie D. alata, el análisis también reveló una composición heterogénea en la región Caribe colombiana. Estos estudios ayudarán a definir una estrategia adecuada para fines de conservación y apoyar los esfuerzos futuros en los programas de mejoramiento genético.

  5. Ultrasonic testing

    Energy Technology Data Exchange (ETDEWEB)

    Song, Sung Jin [Sungkwunkwan Univ., Seoul (Korea, Republic of); Jeong, Hyun Jo [Wonkwang Univ., Iksan (Korea, Republic of)

    2004-02-15

    For the proper performance of ultrasonic testing of steel welded joints, and anisotropic material it is necessary to have sound understanding on the underlying physics. To provide such an understanding, it is beneficial to have simulation tools for ultrasonic testing. In order to address such a need, we develop effective approaches to simulate angle beam ultrasonic testing with a personal computer. The simulation is performed using ultrasonic measurement models based on the computationally efficient multi-Gaussian beams. This reach will describe the developed ultrasonic testing models together with the experimental verification of their accuracy.

  6. Peptide bond-forming reagents HOAt and HATU are not mutagenic in the bacterial reverse mutation test.

    Science.gov (United States)

    Nicolette, John; Neft, Robin E; Vanosdol, Jessica; Murray, Joel

    2016-04-01

    The peptide bond-forming reagents 1-hydroxy-7-azabenzotriazole (HOAt, CAS 39968-33-7) and O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU, CAS 148893-10-1) either have structural alerts, unclassified features or are considered out of domain when evaluated for potential mutagenicity with in silico programs DEREK and CaseUltra. Since they are commonly used reagents in pharmaceutical drug syntheses, they may become drug substance or drug product impurities and would need to be either controlled to appropriately safe levels or tested for mutagenicity. Both reagents were tested in the bacterial reverse mutation (Ames) test at Covance, under GLP conditions, following the OECD test guideline and ICH S2(R1) recommendations and found to be negative. Our data show that HOAt and HATU-common pharmaceutical synthesis reagents-are not mutagenic, and can be treated as ordinary drug impurities. © 2016 Wiley Periodicals, Inc.

  7. Proceedings of the international workshop on aged and decommissioned material collection and testing for structural integrity purposes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This workshop was sponsored by the CEC DG XI and XII/JRC Petten/AMES and by the Principal Working Group 3 (PWG-3) on reactor component integrity of the NEA CSNI, and it was hosted by the CEN Mol, Belgium. The activities of PWG-3 fall into three main areas: non-destructive examination (NDE), fracture analysis, and ageing/materials degradation. The topic of the workshop falls into the third area of ageing and materials degradation. The titles of the papers are: AMES and other European networks in Integrity of Ageing Structures; Over View of Proving Test on the Reliability of Material of Nuclear Power Plant Components; Activities on Ageing Degradation Phenomena of NPP in Korea; Capability of Investigation on Decommissioned Parts from NPPs at the MPA Stuttgart; How Accurately can Surveillance Specimens Reflect the True State of RPV Materials?; Applicability of Design Codes to Aged Materials; Microstructural Investigations of as-Fabricated, Long-Term Thermally Aged and Neutron Irradiated RPV Materials: An Atom Probe Study; Proposed Post-Service Investigations on Decommissioned Greifswald Units; Tools and Experience in Post Irradiation Examination of Structural Core Components at PSI Hot laboratory; Testing of Beznau NPP Unit 1 Steam Generator Cast Stainless Steel Elbows; Mechanical Properties Characterisation of Irradiated Materials From Operating or Decommissioned Nuclear Power Plants; Long Term Ageing of Cast Ti-Stabilised Stainless Steel; Enhanced Surveillance of Nuclear Reactor Pressure Vessels. Discussions and conclusions are also presented

  8. Using information Theory in Optimal Test Point Selection for Health Management in NASA's Exploration Vehicles

    Science.gov (United States)

    Mehr, Ali Farhang; Tumer, Irem

    2005-01-01

    In this paper, we will present a new methodology that measures the "worth" of deploying an additional testing instrument (sensor) in terms of the amount of information that can be retrieved from such measurement. This quantity is obtained using a probabilistic model of RLV's that has been partially developed in the NASA Ames Research Center. A number of correlated attributes are identified and used to obtain the worth of deploying a sensor in a given test point from an information-theoretic viewpoint. Once the information-theoretic worth of sensors is formulated and incorporated into our general model for IHM performance, the problem can be formulated as a constrained optimization problem where reliability and operational safety of the system as a whole is considered. Although this research is conducted specifically for RLV's, the proposed methodology in its generic form can be easily extended to other domains of systems health monitoring.

  9. Service Oriented Robotic Architecture for Space Robotics: Design, Testing, and Lessons Learned

    Science.gov (United States)

    Fluckiger, Lorenzo Jean Marc E; Utz, Hans Heinrich

    2013-01-01

    This paper presents the lessons learned from six years of experiments with planetary rover prototypes running the Service Oriented Robotic Architecture (SORA) developed by the Intelligent Robotics Group (IRG) at the NASA Ames Research Center. SORA relies on proven software engineering methods and technologies applied to space robotics. Based on a Service Oriented Architecture and robust middleware, SORA encompasses on-board robot control and a full suite of software tools necessary for remotely operated exploration missions. SORA has been eld tested in numerous scenarios of robotic lunar and planetary exploration. The experiments conducted by IRG with SORA exercise a large set of the constraints encountered in space applications: remote robotic assets, ight relevant science instruments, distributed operations, high network latencies and unreliable or intermittent communication links. In this paper, we present the results of these eld tests in regard to the developed architecture, and discuss its bene ts and limitations.

  10. Determination of residual 4'-aminomethyl-4,5',8-trimethylpsoralen and mutagenicity testing following psoralen plus UVA treatment of platelet suspensions

    International Nuclear Information System (INIS)

    Wagner, S.J.; Robinette, D.; Dodd, R.Y.; White, R.; Wolf, L.; Chapman, J.; Lawlor, T.E.

    1993-01-01

    Psoralens and UVa light have been used in the laboratory to study the inactivation of viruses that may be infrequently present in platelet concentrates prepared for transfusion. In order to evaluate safety aspects of the treatment of platelet suspensions with 4'-aminomethyl-4,5'8-trimethylpsoralen (AMT), the authors have investigated the residual levels and mutagenic potential of AMT after UVA phototreatment. The results suggest that residual available AMT is mutagenic in the AMES test and that the observed frameshift mutations may be caused by binding of AMt or its metabolites to nucleic acids in the absence of UVA light. (Author)

  11. Determination of residual 4'-aminomethyl-4,5',8-trimethylpsoralen and mutagenicity testing following psoralen plus UVA treatment of platelet suspensions

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, S.J.; Robinette, D.; Dodd, R.Y. (American Red Cross Blood Services, Rockville, MD (United States). Jerome H. Holland Lab. for Biomedical Sciences); White, R.; Wolf, L.; Chapman, J. (Baxter Biotech, Round Lake, IL (United States). Fenwal Labs.); Lawlor, T.E. (Hazleton Labs., Vienna, VA (United States). Molecular and Cellular Toxicology)

    1993-05-01

    Psoralens and UVa light have been used in the laboratory to study the inactivation of viruses that may be infrequently present in platelet concentrates prepared for transfusion. In order to evaluate safety aspects of the treatment of platelet suspensions with 4'-aminomethyl-4,5'8-trimethylpsoralen (AMT), the authors have investigated the residual levels and mutagenic potential of AMT after UVA phototreatment. The results suggest that residual available AMT is mutagenic in the AMES test and that the observed frameshift mutations may be caused by binding of AMt or its metabolites to nucleic acids in the absence of UVA light. (Author).

  12. Troponins Test

    Science.gov (United States)

    ... lab's website in order to provide you with background information about the test(s) you had performed. You will need to return ... C, Banfi G, Guidi GC. Influence of a half-marathon run on NT-proBNP and troponin ... MedlinePlus Medical Encyclopedia [On-line information]. Available online ...

  13. Insulin Test

    Science.gov (United States)

    ... hours before blood is collected, but occasionally a health practitioner may do testing when fasting is not possible, such as when a glucose tolerance test (see Glucose ) is done. In some cases, the health practitioner may request that a person fast longer ...

  14. Genetic Testing

    Science.gov (United States)

    ... is often the only way to determine if symptoms could possibly be related to celiac disease. For a person who faces this situation, a negative gene test would indicate that symptoms are not the result of celiac disease. A positive gene test, however, does not diagnose ...

  15. Potassium test

    Science.gov (United States)

    ... hyperkalemia ) may be due to: Addison disease (rare) Blood transfusion Certain medicines Crushed tissue injury Hyperkalemic periodic paralysis ... released. This may cause a falsely high result. Alternative Names Hypokalemia test; K+ Images Blood test References Mount DB. Disorders of potassium balance. ...

  16. Nationale test

    DEFF Research Database (Denmark)

    Bundsgaard, Jeppe; Puck, Morten Rasmus

    Nationale test skubber undervisning i en forkert retning. Det er lærerne og skolelederne enige om. Men særligt skolelederne ser også muligheder for at bruge testen til at få viden om elevernes faglige kompetencer og om undervisningen. Det kommer til udtryk i rapporten Nationale test: Danske lærere...

  17. Oedometer Tests

    DEFF Research Database (Denmark)

    Thorsen, Grete

    1996-01-01

    The paper describes the results of oedometer tests carried out with samples from Eemian fresh-water deposits and the methods used to determine the preconsolidation pressure from the test results. The influence of creep in the material on the apparent preconsolidation pressure is estimated from...

  18. TORCH Test

    Science.gov (United States)

    ... Parietal Cell Antibody Partial Thromboplastin Time (PTT, aPTT) Parvovirus B19 Pericardial Fluid Analysis Peritoneal Fluid Analysis Pertussis Tests ... enterovirus, Epstein-Barr virus , varicella-zoster virus , and parvovirus B19 . How is the sample collected for testing? A ...

  19. Automating Test Activities: Test Cases Creation, Test Execution, and Test Reporting with Multiple Test Automation Tools

    OpenAIRE

    Loke Mun Sei

    2015-01-01

    Software testing has become a mandatory process in assuring the software product quality. Hence, test management is needed in order to manage the test activities conducted in the software test life cycle. This paper discusses on the challenges faced in the software test life cycle, and how the test processes and test activities, mainly on test cases creation, test execution, and test reporting is being managed and automated using several test automation tools, i.e. Jira, ...

  20. Study of the heavy ions (Au+Au at 150 AMeV) collisions with the FOPI detector. Comparison with the Landau-Vlasov model; Etude des collisions d`ions lourds AU+AU a 150 A.MeV avec le detecteur FOPI. Comparaison avec le modele de Landau-Vlasov

    Energy Technology Data Exchange (ETDEWEB)

    Boussange, S

    1995-09-15

    In this thesis, heavy ions (Au+Au) collisions experiments are made at 150 AMeV.In the first part, a general study of the nuclear matter equation is presented. Then the used Landau-Vlasov theoretical model is describe. The third part presents the FOPI experience and the details of how to obtain this theoretical predictions (filter, cuts, corrections, possible centrality selections).At the end, experimental results and comparisons with the Landau-Vlasov model are presented. (TEC). 105 refs., 96 figs., 14 tabs.

  1. Trypsinogen test

    Science.gov (United States)

    ... care provider about the meaning of your specific test results. What Abnormal Results ... vary in size, so it may be harder to get a blood sample from one person than another. Other risks associated with having ...

  2. Just testing

    International Nuclear Information System (INIS)

    Robinson, D.

    1985-01-01

    In the 1950s, most of the men who witnessed Britain's nuclear tests at Christmas Island in the Pacific were national servicemen, aged 19 or 20. Some revelled in sun and swimming, some were bored, some were too busy to be bored. How many of the twenty thousand servicemen involved in the tests suspected that they might be exposed to radiation that would reveal itself a generation later in blood and bone cancers, sterility, cataracts, or deformities in their children. The Ministry of Defence insists nobody was in danger. This book tells a different story, in the words of the servicemen, and of their medical reports, about secrets which are no longer Official. It is important not only to the victims of a government's extraordinary reluctance to face up to the tragic consequences of a programme of nuclear tests on Christmas Island and in Australia, but to anyone concerned with the damage that nuclear testing is still doing in the world today. (author)

  3. Test Ship

    Data.gov (United States)

    Federal Laboratory Consortium — The U. S. Navy dedicated the decommissioned Spruance Class destroyer ex-PAUL F. FOSTER (EDD 964), Test Ship, primarily for at sea demonstration of short range weapon...

  4. Injection Tests

    CERN Document Server

    Kain, V

    2009-01-01

    The success of the start-up of the LHC on 10th of September was in part due to the preparation without beam and injection tests in 2008. The injection tests allowed debugging and improvement in appropriate portions to allow safe, efficient and state-of-the-art commissioning later on. The usefulness of such an approach for a successful start-up becomes obvious when looking at the problems we encountered before and during the injection tests and could solve during this period. The outline of the preparation and highlights of the different injection tests will be presented and the excellent performance of many tools discussed. A list of shortcomings will follow, leading to some planning for the preparation of the run in 2009.

  5. Fungal Tests

    Science.gov (United States)

    ... Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 1569, 1570, 1532, 1616. Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology, Twelfth Edition: Mosby Elsevier Press, St. Louis, Missouri. ...

  6. PTH Test

    Science.gov (United States)

    ... Gregory C. Sephel PhD FACB MT(ASCP). Lab Tests Online adjunct board member. Director Clinical Pathology, VA TN Valley Healthcare System; Associate Professor Pathology, Microbiology, Immunology, Vanderbilt University School of Medicine. Sources Used ...

  7. Phosphorus Test

    Science.gov (United States)

    ... be seen with increased intake of the mineral, hypocalcemia , and with kidney dysfunction. Someone with a mild ... usually detected because of the relationship with and effect on calcium levels . Calcium is routinely tested as ...

  8. Procalcitonin Test

    Science.gov (United States)

    ... normal" values. By comparing your test results with reference values, you and your healthcare provider can see if ... g., blood culture , urine culture ), lactate , blood gases , complete blood count (CBC) , and cerebrospinal fluid (CSF) analysis . When is ...

  9. RSV Test

    Science.gov (United States)

    ... Sex Hormone Binding Globulin (SHBG) Shiga toxin-producing Escherichia coli Sickle Cell Tests Sirolimus Smooth Muscle Antibody (SMA) ... University Medical Center, LAB Letter [On-line newsletter]. PDF available for download at http://www.stanfordhospital.com/ ...

  10. Prenatal Tests

    Science.gov (United States)

    ... tests are considered routine — that is, almost all pregnant women receiving prenatal care get them. They include things like checking urine (pee) levels for protein, sugar, or signs of infection. Other non-routine ...

  11. Progesterone Test

    Science.gov (United States)

    ... replacement therapy, or help diagnose the cause of abnormal uterine bleeding When To Get Tested? At specific times during ... receiving progesterone replacement therapy; when a woman has abnormal uterine bleeding Sample Required? A blood sample drawn from a ...

  12. Testosterone Test

    Science.gov (United States)

    ... Testing Triglycerides Troponin Tryptase Tumor Markers Uric Acid Urinalysis Urine Albumin and Albumin/Creatinine Ratio Urine Culture ... 2010) 2536–259. Centers for Disease Control Hormone Standardization website(HoST). Available online at http://www.cdc. ...

  13. Pertussis Tests

    Science.gov (United States)

    ... of Conditions Not Listed? Not Listed? Acidosis and Alkalosis Adrenal Insufficiency and Addison Disease Alcoholism Allergies Alzheimer ... tested? Pertussis, commonly called whooping cough, is a respiratory infection caused by the bacteria Bordetella pertussis . These ...

  14. Tests computarizados

    Directory of Open Access Journals (Sweden)

    R. Fernando Prialé Z.

    1983-12-01

    Full Text Available En primer lugar, se considera el impacto de las microcomputadoras en la actualidad, viéndolo como un hecho social destinado a traer profundos cambios: nos orientamos hacia una cultura informática cuyo signo es la posibilidad de tratar grandes cantidades de información. En segundo lugar; se analiza brevemente la importancia de los tests en el desarrollo de la psicología. Finalmente, se discute la posibilidad de aplicar la informática a la psicometría con el ejemplo del test de BARSIT.   The impact of microcomputers is discussed as a cultural fact that will bring profound changes in the near future: a society with an ubiquous capacity for treating big amounts of information. The importance of tests for the development of psychology is then analysed. Finaly, the possibility of applying microcomputers to psychometry is discussed trough a concrete example: The BARSIT test.

  15. VMA Test

    Science.gov (United States)

    ... spasms and rapid eye movements referred to as "dancing eyes, dancing feet." The VMA test may also be ordered ... a pheochromocytoma or neuroblastoma? People with a family history of multiple endocrine neoplasia (MEN2), a genetic condition ...

  16. Neuropsychological testing.

    Science.gov (United States)

    Zucchella, Chiara; Federico, Angela; Martini, Alice; Tinazzi, Michele; Bartolo, Michelangelo; Tamburin, Stefano

    2018-06-01

    Neuropsychological testing is a key diagnostic tool for assessing people with dementia and mild cognitive impairment, but can also help in other neurological conditions such as Parkinson's disease, stroke, multiple sclerosis, traumatic brain injury and epilepsy. While cognitive screening tests offer gross information, detailed neuropsychological evaluation can provide data on different cognitive domains (visuospatial function, memory, attention, executive function, language and praxis) as well as neuropsychiatric and behavioural features. We should regard neuropsychological testing as an extension of the neurological examination applied to higher order cortical function, since each cognitive domain has an anatomical substrate. Ideally, neurologists should discuss the indications and results of neuropsychological assessment with a clinical neuropsychologist. This paper summarises the rationale, indications, main features, most common tests and pitfalls in neuropsychological evaluation. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  17. Testing theories

    International Nuclear Information System (INIS)

    Casten, R F

    2015-01-01

    This paper discusses some simple issues that arise in testing models, with a focus on models for low energy nuclear structure. By way of simplified examples, we illustrate some dangers in blind statistical assessments, pointing out especially the need to include theoretical uncertainties, the danger of over-weighting precise or physically redundant experimental results, the need to assess competing theories with independent and physically sensitive observables, and the value of statistical tests properly evaluated. (paper)

  18. Hardware Design and Testing of SUPERball, A Modular Tensegrity Robot

    Science.gov (United States)

    Sabelhaus, Andrew P.; Bruce, Jonathan; Caluwaerts, Ken; Chen, Yangxin; Lu, Dizhou; Liu, Yuejia; Agogino, Adrian K.; SunSpiral, Vytas; Agogino, Alice M.

    2014-01-01

    We are developing a system of modular, autonomous "tensegrity end-caps" to enable the rapid exploration of untethered tensegrity robot morphologies and functions. By adopting a self-contained modular approach, different end-caps with various capabilities (such as peak torques, or motor speeds), can be easily combined into new tensegrity robots composed of rods, cables, and actuators of different scale (such as in length, mass, peak loads, etc). As a first step in developing this concept, we are in the process of designing and testing the end-caps for SUPERball (Spherical Underactuated Planetary Exploration Robot), a project at the Dynamic Tensegrity Robotics Lab (DTRL) within NASA Ames's Intelligent Robotics Group. This work discusses the evolving design concepts and test results that have gone into the structural, mechanical, and sensing aspects of SUPERball. This representative tensegrity end-cap design supports robust and repeatable untethered mobility tests of the SUPERball, while providing high force, high displacement actuation, with a low-friction, compliant cabling system.

  19. Allergy testing - skin

    Science.gov (United States)

    Patch tests - allergy; Scratch tests - allergy; Skin tests - allergy; RAST test; Allergic rhinitis - allergy testing; Asthma - allergy testing; Eczema - allergy testing; Hayfever - allergy testing; Dermatitis - allergy testing; Allergy testing; ...

  20. End-to-End System Test of the Relative Precision and Stability of the Photometric Method for Detecting Earth-Size Extrasolar Planets

    Science.gov (United States)

    Dunham, Edward W.

    2000-01-01

    We developed the CCD camera system for the laboratory test demonstration and designed the optical system for this test. The camera system was delivered to Ames in April, 1999 with continuing support mostly in the software area as the test progressed. The camera system has been operating successfully since delivery. The optical system performed well during the test. The laboratory demonstration activity is now nearly complete and is considered to be successful by the Technical Advisory Group, which met on 8 February, 2000 at the SETI Institute. A final report for the Technical Advisory Group and NASA Headquarters will be produced in the next few months. This report will be a comprehensive report on all facets of the test including those covered under this grant. A copy will be forwarded, if desired, when it is complete.

  1. Adaptive test

    DEFF Research Database (Denmark)

    Kjeldsen, Lars Peter; Eriksen, Mette Rose

    2010-01-01

    Artikelen er en evaluering af de adaptive tests, som blev indført i folkeskolen. Artiklen sætter særligt fokus på evaluering i folkeskolen, herunder bidrager den med vejledning til evaluering, evalueringsværktøjer og fagspecifkt evalueringsmateriale.......Artikelen er en evaluering af de adaptive tests, som blev indført i folkeskolen. Artiklen sætter særligt fokus på evaluering i folkeskolen, herunder bidrager den med vejledning til evaluering, evalueringsværktøjer og fagspecifkt evalueringsmateriale....

  2. Tests computarizados

    OpenAIRE

    Prialé Z., R. Fernando

    1983-01-01

    En primer lugar, se considera el impacto de las microcomputadoras en la actualidad, viéndolo como un hecho social destinado a traer profundos cambios: nos orientamos hacia una cultura informática cuyo signo es la posibilidad de tratar grandes cantidades de información. En segundo lugar; se analiza brevemente la importancia de los tests en el desarrollo de la psicología. Finalmente, se discute la posibilidad de aplicar la informática a la psicometría con el ejemplo del test de BARSIT.   The im...

  3. Free Flight Ground Testing of ADEPT in Advance of the Sounding Rocket One Flight Experiment

    Science.gov (United States)

    Smith, B. P.; Dutta, S.

    2017-01-01

    The Adaptable Deployable Entry and Placement Technology (ADEPT) project will be conducting the first flight test of ADEPT, titled Sounding Rocket One (SR-1), in just two months. The need for this flight test stems from the fact that ADEPT's supersonic dynamic stability has not yet been characterized. The SR-1 flight test will provide critical data describing the flight mechanics of ADEPT in ballistic flight. These data will feed decision making on future ADEPT mission designs. This presentation will describe the SR-1 scientific data products, possible flight test outcomes, and the implications of those outcomes on future ADEPT development. In addition, this presentation will describe free-flight ground testing performed in advance of the flight test. A subsonic flight dynamics test conducted at the Vertical Spin Tunnel located at NASA Langley Research Center provided subsonic flight dynamics data at high and low altitudes for multiple center of mass (CoM) locations. A ballistic range test at the Hypervelocity Free Flight Aerodynamics Facility (HFFAF) located at NASA Ames Research Center provided supersonic flight dynamics data at low supersonic Mach numbers. Execution and outcomes of these tests will be discussed. Finally, a hypothesized trajectory estimate for the SR-1 flight will be presented.

  4. Testing Hubbert

    International Nuclear Information System (INIS)

    Brandt, Adam R.

    2007-01-01

    The Hubbert theory of oil depletion, which states that oil production in large regions follows a bell-shaped curve over time, has been cited as a method to predict the future of global oil production. However, the assumptions of the Hubbert method have never been rigorously tested with a large, publicly available data set. In this paper, three assumptions of the modern Hubbert theory are tested using data from 139 oil producing regions. These regions are sub-national (United States state-level, United States regional-level), national, and multi-national (subcontinental and continental) in scale. We test the assumption that oil production follows a bell-shaped curve by generating best-fitting curves for each region using six models and comparing the quality of fit across models. We also test the assumptions that production over time in a region tends to be symmetric, and that production is more bell-shaped in larger regions than in smaller regions

  5. Prealbumin Test

    Science.gov (United States)

    ... T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 755-756. Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 197. Banh, L. ( ...

  6. Genomic Testing

    Science.gov (United States)

    ... this database. Top of Page Evaluation of Genomic Applications in Practice and Prevention (EGAPP™) In 2004, the Centers for Disease Control and Prevention launched the EGAPP initiative to establish and test a ... and other applications of genomic technology that are in transition from ...

  7. Fibrinogen Test

    Science.gov (United States)

    ... thrombotic episode ) As a follow-up to an abnormal bleeding disorder test ( prothrombin time, PT or partial thromboplastin time, ... to help diagnose disseminated intravascular coagulation (DIC) or abnormal ... status of a progressive disease (such as liver disease ) over time or, rarely, ...

  8. (stress) testing

    African Journals Online (AJOL)

    However, maximal HR was significantly higher in all groups during their sporting activities than during stress testing in the laboratory (P < 0.01). Conclusions. Maximal HR in veteran athletes during specific sporting activities was significantly higher than that attained during a routine sECG. This finding was not sport-specific, ...

  9. Trypsinogen Test

    Science.gov (United States)

    ... exocrine.html. UPCMD (1998 – 2002). Cystic Fibrosis. University Pathology Consortium, LLC [On-line information]. Available online at http://www.upcmd.com/dot/examples/00218/description.html. Sainato, D., (2002, March). Genetic Testing for CF Going Mainstream? Clinical Laboratory ...

  10. Chymotrypsin Test

    Science.gov (United States)

    ... exocrine.html. UPCMD (1998 – 2002). Cystic Fibrosis. University Pathology Consortium, LLC [On-line information]. Available online at http://www.upcmd.com/dot/examples/00218/description.html. Sainato, D., (2002, March). Genetic Testing for CF Going Mainstream? Clinical Laboratory ...

  11. Overview of the Space Launch System Ascent Aeroacoustic Environment Test Program

    Science.gov (United States)

    Herron, Andrew J.; Crosby, William A.; Reed, Darren K.

    2016-01-01

    Characterization of accurate flight vehicle unsteady aerodynamics is critical for component and secondary structure vibroacoustic design. The Aerosciences Branch at the National Aeronautics and Space Administration (NASA) Marshall Space Flight Center has conducted a test at the NASA Ames Research Center (ARC) Unitary Plan Wind Tunnels (UPWT) to determine such ascent aeroacoustic environments for the Space Launch System (SLS). Surface static pressure measurements were also collected to aid in determination of local environments for venting, CFD substantiation, and calibration of the flush air data system located on the launch abort system. Additionally, this test supported a NASA Engineering and Safety Center study of alternate booster nose caps. Testing occurred during two test campaigns: August - September 2013 and December 2013 - January 2014. Four primary model configurations were tested for ascent aeroacoustic environment definition. The SLS Block 1 vehicle was represented by a 2.5% full stack model and a 4% truncated model. Preliminary Block 1B payload and manned configurations were also tested, using 2.5% full stack and 4% truncated models respectively. This test utilized the 11 x 11 foot transonic and 9 x 7 foot supersonic tunnel sections at the ARC UPWT to collect data from Mach 0.7 through 2.5 at various total angles of attack. SLS Block 1 design environments were developed primarily using these data. SLS Block 1B preliminary environments have also been prepared using these data. This paper discusses the test and analysis methodology utilized, with a focus on the unsteady data collection and processing.

  12. Radiographic Test

    Energy Technology Data Exchange (ETDEWEB)

    Lee, H.J; Yang, S.H. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    This report contains theory, procedure technique and interpretation of radiographic examination and written for whom preparing radiographic test Level II. To determine this baseline of technical competence in the examination, the individual must demonstrate a knowledge of radiography physics, radiation safety, technique development, radiation detection and measurement, facility design, and the characteristics of radiation-producing devices and their principles of operation. (author) 98 figs., 23 tabs.

  13. Testing Understanding and Understanding Testing.

    Science.gov (United States)

    Pedersen, Jean; Ross, Peter

    1985-01-01

    Provides examples in which graphs are used in the statements of problems or in their solutions as a means of testing understanding of mathematical concepts. Examples (appropriate for a beginning course in calculus and analytic geometry) include slopes of lines and curves, quadratic formula, properties of the definite integral, and others. (JN)

  14. Credibility test; Vertrauens-Test

    Energy Technology Data Exchange (ETDEWEB)

    Fuhs, Michael

    2009-07-01

    Solar wafer producers must prove their quality standards. Q-Cells has started a marketing office and opened their test center to journalists. They are aware that adherence to standards is going only half the way of quality assurance. The other half consists in gaining the customers' trust. (orig.)

  15. Life-Cycle Assessments of Selected NASA Ground-Based Test Facilities

    Science.gov (United States)

    Sydnor, George Honeycutt

    2012-01-01

    In the past two years, two separate facility-specific life cycle assessments (LCAs) have been performed as summer student projects. The first project focused on 13 facilities managed by NASA s Aeronautics Test Program (ATP), an organization responsible for large, high-energy ground test facilities that accomplish the nation s most advanced aerospace research. A facility inventory was created for each facility, and the operational-phase carbon footprint and environmental impact were calculated. The largest impacts stemmed from electricity and natural gas used directly at the facility and to generate support processes such as compressed air and steam. However, in specialized facilities that use unique inputs like R-134a, R-14, jet fuels, or nitrogen gas, these sometimes had a considerable effect on the facility s overall environmental impact. The second LCA project was conducted on the NASA Ames Arc Jet Complex and also involved creating a facility inventory and calculating the carbon footprint and environmental impact. In addition, operational alternatives were analyzed for their effectiveness at reducing impact. Overall, the Arc Jet Complex impact is dominated by the natural-gas fired boiler producing steam on-site, but alternatives were provided that could reduce the impact of the boiler operation, some of which are already being implemented. The data and results provided by these LCA projects are beneficial to both the individual facilities and NASA as a whole; the results have already been used in a proposal to reduce carbon footprint at Ames Research Center. To help future life cycle projects, several lessons learned have been recommended as simple and effective infrastructure improvements to NASA, including better utility metering and data recording and standardization of modeling choices and methods. These studies also increased sensitivity to and appreciation for quantifying the impact of NASA s activities.

  16. Integrated Testing of a 4-Bed Molecular Sieve, Air-Cooled Temperature Swing Adsorption Compressor, and Sabatier Engineering Development Unit

    Science.gov (United States)

    Knox, James C.; Miller, Lee; Campbell, Melissa; Mulloth, Lila; Varghese, Mini

    2006-01-01

    Accumulation and subsequent compression of carbon dioxide that is removed from the space cabin are two important processes involved in a closed-loop air revitalization scheme of the International Space Station (ISS). The 4-Bed Molecular Sieve (4BMS) of ISS currently operates in an open loop mode without a compressor. The Sabatier Engineering Development Unit (EDU) processes waste CO2 to provide water to the crew. This paper reports the integrated 4BMS, air-cooled Temperature Swing Adsorption Compressor (TSAC), and Sabatier EDU testing. The TSAC prototype was developed at NASA Ames Research Center (ARC). The 4BMS was modified to a functionally flight-like condition at NASA Marshall Space Flight Center (MSFC). Testing was conducted at MSFC. The paper provides details of the TSAC operation at various CO2 loadings and corresponding performance of the 4BMS and Sabatier.

  17. Knowledge Test

    DEFF Research Database (Denmark)

    Sørensen, Ole Henning

    1998-01-01

    The knowledge test is about competing temporal and spatial expressions of the politics of technological development and national prosperity in contemporary society. The discussion is based on literature of national systems of innovation and industrial networks of various sorts. Similarities...... and differences in the disparate theories are discussed through a critical perspective on metaphor, time, space, agency and technology. It is asserted that the process of globalization is leading to a new production of space-time perceptions and practices where localization and globalization is becoming...... increasingly important. National space is being contested and nation states need to perform differently....

  18. Testing SUSY

    CERN Document Server

    Cassel, S; Ross, G G

    2010-01-01

    If SUSY provides a solution to the hierarchy problem then supersymmetric states should not be too heavy. This requirement is quantified by the Barbieri-Giudice fine tuning measure that provides a quantitative test of SUSY as a solution to the hierarchy problem. The measure is useful in correlating the impact of the various experimental measurements relevant to the search for supersymmetry and also in identifying the most sensitive measurements for testing SUSY. In this paper we apply the measure to the CMSSM, computing it to two-loop order and taking account of current experimental limits and the constraint on dark matter abundance. Using this we determine the present limits on the CMSSM parameter space and identify the measurements at the LHC that are most significant in covering the remaining parameter space. Without imposing the LEP Higgs mass bound we show that the smallest fine tuning (1:14.5) consistent with a saturation of the relic density within the 1$\\sigma$ WMAP bounds corresponds to a Higgs mass o...

  19. Heart failure - tests

    Science.gov (United States)

    CHF - tests; Congestive heart failure - tests; Cardiomyopathy - tests; HF - tests ... the best test to: Identify which type of heart failure (systolic, diastolic, valvular) Monitor your heart failure and ...

  20. Nuclear stress test

    Science.gov (United States)

    ... Persantine stress test; Thallium stress test; Stress test - nuclear; Adenosine stress test; Regadenoson stress test; CAD - nuclear stress; Coronary artery disease - nuclear stress; Angina - nuclear ...

  1. CARACTERÍSTICAS FISICOQUÍMICAS Y MORFOLÓGICAS DE RIZÓFOROS DE ÑAME (Dioscorea alata) CARACTERÍSTICAS FÍSICOQUÍMICAS E MORFOLÓGICAS DE RIZÓFOROS DE INHAME (Dioscorea alata) PHYSICOCHEMICAL AND MORPHOLOGIC CHARACTERISTICS OF THE RIZÓFOROS OF YAM (Dioscorea alata)

    OpenAIRE

    CLÁUDIA DENISE DE PAULA; MÔNICA PIROZI; MARIO PUIATTI; JOÃO T. BORGES; ALBA M. DURANGO

    2012-01-01

    En este trabajo se determino la composición físico-química y las características morfológicas de los rizóforos de seis variedades de ñame (Dioscorea alata) del Banco de Germoplasma de Hortalizas (BGH) de la Universidade Federal de Viçosa (UFV). Fue determinada la composición centesimal mediante análisis de humedad, lípidos, proteína, cenizas, fibra bruta y carbohidratos. Las características morfológicas fueron estudiadas visualmente y por análisis microscópicos. La composición físico-química ...

  2. Computer-Based Testing: Test Site Security.

    Science.gov (United States)

    Rosen, Gerald A.

    Computer-based testing places great burdens on all involved parties to ensure test security. A task analysis of test site security might identify the areas of protecting the test, protecting the data, and protecting the environment as essential issues in test security. Protecting the test involves transmission of the examinations, identifying the…

  3. Second-Generation Large Civil Tiltrotor 7- by 10-Foot Wind Tunnel Test Data Report

    Science.gov (United States)

    Theodore, Colin R.; Russell, Carl R.; Willink, Gina C.; Pete, Ashley E.; Adibi, Sierra A.; Ewert, Adam; Theuns, Lieselotte; Beierle, Connor

    2016-01-01

    An approximately 6-percent scale model of the NASA Second-Generation Large Civil Tiltrotor (LCTR2) Aircraft was tested in the U.S. Army 7- by 10-Foot Wind Tunnel at NASA Ames Research Center January 4 to April 19, 2012, and September 18 to November 1, 2013. The full model was tested, along with modified versions in order to determine the effects of the wing tip extensions and nacelles; the wing was also tested separately in the various configurations. In both cases, the wing and nacelles used were adopted from the U.S. Army High Efficiency Tilt Rotor (HETR) aircraft, in order to limit the cost of the experiment. The full airframe was tested in high-speed cruise and low-speed hover flight conditions, while the wing was tested only in cruise conditions, with Reynolds numbers ranging from 0 to 1.4 million. In all cases, the external scale system of the wind tunnel was used to collect data. Both models were mounted to the scale using two support struts attached underneath the wing; the full airframe model also used a third strut attached at the tail. The collected data provides insight into the performance of the preliminary design of the LCTR2 and will be used for computational fluid dynamics (CFD) validation and the development of flight dynamics simulation models.

  4. Initial closed operation of the CELSS Test Facility Engineering Development Unit

    Science.gov (United States)

    Kliss, M.; Blackwell, C.; Zografos, A.; Drews, M.; MacElroy, R.; McKenna, R.; Heyenga, A. G.

    2003-01-01

    As part of the NASA Advanced Life Support Flight Program, a Controlled Ecological Life Support System (CELSS) Test Facility Engineering Development Unit has been constructed and is undergoing initial operational testing at NASA Ames Research Center. The Engineering Development Unit (EDU) is a tightly closed, stringently controlled, ground-based testbed which provides a broad range of environmental conditions under which a variety of CELSS higher plant crops can be grown. Although the EDU was developed primarily to provide near-term engineering data and a realistic determination of the subsystem and system requirements necessary for the fabrication of a comparable flight unit, the EDU has also provided a means to evaluate plant crop productivity and physiology under controlled conditions. This paper describes the initial closed operational testing of the EDU, with emphasis on the hardware performance capabilities. Measured performance data during a 28-day closed operation period are compared with the specified functional requirements, and an example of inferring crop growth parameters from the test data is presented. Plans for future science and technology testing are also discussed. Published by Elsevier Science Ltd on behalf of COSPAR.

  5. Mononucleosis spot test

    Science.gov (United States)

    Monospot test; Heterophile antibody test; Heterophile agglutination test; Paul-Bunnell test; Forssman antibody test ... The mononucleosis spot test is done when symptoms of mononucleosis are ... Fatigue Fever Large spleen (possibly) Sore throat Tender ...

  6. Coccidioides precipitin test

    Science.gov (United States)

    Coccidioidomycosis antibody test; Coccidioides blood test; Valley fever blood test ... There is no special preparation for the test. ... The precipitin test is one of several tests that can be done to determine if you are infected with coccidioides, which ...

  7. Myoglobin urine test

    Science.gov (United States)

    Urine myoglobin; Heart attack - myoglobin urine test; Myositis - myoglobin urine test; Rhabdomyolysis - myoglobin urine test ... The test involves only normal urination, which should cause no discomfort.

  8. Results of an air data probe investigation utilizing a 0.10 scale orbiter forebody (model 57-0) in the Ames Research Center 14-foot wind tunnel (OA220)

    Science.gov (United States)

    Esparza, V.; Thornton, D. E.

    1976-01-01

    Results are presented of a 0.10 scale orbiter forebody test with left and right mounted air data probes (ADP) as well as a flight test probe (nose boom). Left and right ADP data were obtained at Mach numbers of .3, .4, .5, .6, .7, .8, .85, .9, .95, .98, 1.05 and 1.1 through a Reynolds number range of 1.3 to 4.4 million. Nose boom data were obtained at Mach numbers of .3, .4, .5, .6, .7, .9 and .98.

  9. Integrated Testing of a 4-Bed Molecular Sieve and a Temperature-Swing Adsorption Compressor for Closed-Loop Air Revitalization

    Science.gov (United States)

    Knox, James C.; Mulloth, Lila M.; Affleck, David L.

    2004-01-01

    Accumulation and subsequent compression of carbon dioxide that is removed from space cabin are two important processes involved in a closed-loop air revitalization scheme of the International Space Station (ISS). The 4-Bed Molecular Sieve (4BMS) of ISS currently operates in an open loop mode without a compressor. This paper reports the integrated 4BMS and liquid-cooled TSAC testing conducted during the period of March 3 to April 18, 2003. The TSAC prototype was developed at NASA Ames Research Center (ARC). The 4BMS was modified to a functionally flight-like condition at NASA Marshall Space Flight Center (MSFC). Testing was conducted at MSFC. The paper provides details of the TSAC operation at various CO2 loadings and corresponding performance of CDRA.

  10. Underground Nuclear Testing Program, Nevada Test Site

    International Nuclear Information System (INIS)

    1975-09-01

    The Energy Research and Development Administration (ERDA) continues to conduct an underground nuclear testing program which includes tests for nuclear weapons development and other tests for development of nuclear explosives and methods for their application for peaceful uses. ERDA also continues to provide nuclear explosive and test site support for nuclear effects tests sponsored by the Department of Defense. This Supplement extends the Environmental Statement (WASH-1526) to cover all underground nuclear tests and preparations for tests of one megaton (1 MT) or less at the Nevada Test Site (NTS) during Fiscal Year 1976. The test activities covered include numerous continuing programs, both nuclear and non-nuclear, which can best be conducted in a remote area. However, if nuclear excavation tests or tests of yields above 1 MT or tests away from NTS should be planned, these will be covered by separate environmental statements

  11. Reliability of specific physical examination tests for the diagnosis of shoulder pathologies: a systematic review and meta-analysis.

    Science.gov (United States)

    Lange, Toni; Matthijs, Omer; Jain, Nitin B; Schmitt, Jochen; Lützner, Jörg; Kopkow, Christian

    2017-03-01

    Shoulder pain in the general population is common and to identify the aetiology of shoulder pain, history, motion and muscle testing, and physical examination tests are usually performed. The aim of this systematic review was to summarise and evaluate intrarater and inter-rater reliability of physical examination tests in the diagnosis of shoulder pathologies. A comprehensive systematic literature search was conducted using MEDLINE, EMBASE, Allied and Complementary Medicine Database (AMED) and Physiotherapy Evidence Database (PEDro) through 20 March 2015. Methodological quality was assessed using the Quality Appraisal of Reliability Studies (QAREL) tool by 2 independent reviewers. The search strategy revealed 3259 articles, of which 18 finally met the inclusion criteria. These studies evaluated the reliability of 62 test and test variations used for the specific physical examination tests for the diagnosis of shoulder pathologies. Methodological quality ranged from 2 to 7 positive criteria of the 11 items of the QAREL tool. This review identified a lack of high-quality studies evaluating inter-rater as well as intrarater reliability of specific physical examination tests for the diagnosis of shoulder pathologies. In addition, reliability measures differed between included studies hindering proper cross-study comparisons. PROSPERO CRD42014009018. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  12. Test Review: TestDaF

    Science.gov (United States)

    Norris, John; Drackert, Anastasia

    2018-01-01

    The Test of German as a Foreign Language (TestDaF) plays a critical role as a standardized test of German language proficiency. Developed and administered by the Society for Academic Study Preparation and Test Development (g.a.s.t.), TestDaF was launched in 2001 and has experienced persistent annual growth, with more than 44,000 test takers in…

  13. Tests Related to Pregnancy

    Science.gov (United States)

    ... to learn. Search form Search Tests related to pregnancy You are here Home Testing & Services Testing for ... to Genetic Counseling . What Are Tests Related to Pregnancy? Pregnancy related testing is done before or during ...

  14. Short-term Exposure to a Mediterranean Environment Influences Attitudes and Dietary Profile in U.S. College Students: The MEDiterranean Diet in AMEricans (A-MED-AME) Pilot Study.

    Science.gov (United States)

    Petroka, Katherine; Dinu, Monica; Hoover, Chelsea; Casini, Alessandro; Sofi, Francesco

    2016-01-01

    The aim of this study was to investigate whether short-term exposure to a Mediterranean diet during a structured abroad experience could influence dietary habits and attitudes. This study used a cross-sectional design. The study was conducted on the Florence University of the Arts (FUA) campus, Italy. Fifty-four (47 females, 7 males; mean age 21.1 ± 1.9 years) college students from 12 different states, mainly located in the central United States, were enrolled in this study. Outcome measures included adherence score to Mediterranean diet and self-reported perceptions of diet and food availability. A demographic survey was used to collect data regarding personal characteristics, anthropometrics, duration of stay, and residency status. Chi-square test, independent T-test, and Mann-Whitney test were used to perform analyses. At 3 weeks' follow-up, 94% of the population reported that availability of foods affected their food choices. Interestingly, students reported that they consumed less meat with respect to their usual dietary habits in the United States (p Mediterranean diet significantly increased by about 1 point, going from 9.9 ± 2.4 to 10.9 ± 2.0 (p Mediterranean diet was observed. Future research should explore the relationship between length of time spent in a foreign country and dietary adherence in a cultural context.

  15. Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the "health-related indication value (HRIV) concept.

    Science.gov (United States)

    Prantl, Eva-Maria; Kramer, Meike; Schmidt, Carsten K; Knauer, Martina; Gartiser, Stefan; Shuliakevich, Aliaksandra; Milas, Julia; Glatt, Hansruedi; Meinl, Walter; Hollert, Henner

    2018-02-01

    In numerous cases, the German health-related indication value (HRIV) concept has proved its practicability for the assessment of drinking water relevant trace substances (Umweltbundesamt 2003). The HRIV is based on the toxicological profile of a substance. An open point of the HRIV concept has been the assignment of standardized test procedures to be used for the assessment. The level of the HRIV is at its lowest as soon as the genotoxicity of the substance is detected. As a single test on its own, it is not sufficient enough to assess the human toxicological relevance of a genotoxic effect or exclude it in the case of a negative result; a reasonable test battery was required, technically oriented towards the already harmonized international, hierarchical evaluation for toxicological assessment of chemicals. Therefore, an important aim of this project was to define a strategy for the genotoxicological assessment of anthropogenic trace substances. The basic test battery for genotoxicity of micropollutants in drinking water needs to fulfill several requirements. Although quick test results are needed for the determination of HRIV, a high degree of transferability to human genotoxicity should be ensured. Therefore, an in vitro genotoxicity test battery consisting of the Ames fluctuation test with two tester strains (ISO 11350), the umu test and the micronucleus test, or from the Ames test with five tester strains (OECD 471) and the micronucleus test is proposed. On the basis of selected test substances, it could be shown that the test battery leads to positive, indifferent, and negative results. Given indifferent results, the health authority and the water supplier must assume that it is a genotoxic substance. Genetically modified tester strains are being sensitive to different chemical classes by expression of selected mammalian key enzymes for example nitroreductase, acetyltransferase, and glutathione-S-transferase. These strains may provide valuable additional

  16. Design Driven Testing Test Smarter, Not Harder

    CERN Document Server

    Stephens, M

    2010-01-01

    The groundbreaking book Design Driven Testing brings sanity back to the software development process by flipping around the concept of Test Driven Development (TDD) - restoring the concept of using testing to verify a design instead of pretending that unit tests are a replacement for design. Anyone who feels that TDD is "Too Damn Difficult" will appreciate this book. Design Driven Testing shows that, by combining a forward-thinking development process with cutting-edge automation, testing can be a finely targeted, business-driven, rewarding effort. In other words, you'll learn how to test

  17. Learning software testing with Test Studio

    CERN Document Server

    Madi, Rawane

    2013-01-01

    Learning Software Testing with Test Studio is a practical, hands-on guide that will help you get started with Test Studio to design your automated solution and tests. All through the book, there are best practices and tips and tricks inside Test Studio which can be employed to improve your solution just like an experienced QA.If you are a beginner or a professional QA who is seeking a fast, clear, and direct to the point start in automated software testing inside Test Studio, this book is for you. You should be familiar with the .NET framework, mainly Visual Studio, C#, and SQL, as the book's

  18. NASA ERA Integrated CFD for Wind Tunnel Testing of Hybrid Wing-Body Configuration

    Science.gov (United States)

    Garcia, Joseph A.; Melton, John E.; Schuh, Michael; James, Kevin D.; Long, Kurt R.; Vicroy, Dan D.; Deere, Karen A.; Luckring, James M.; Carter, Melissa B.; Flamm, Jeffrey D.; hide

    2016-01-01

    NASAs Environmentally Responsible Aviation (ERA) Project explores enabling technologies to reduce aviations impact on the environment. One research challenge area for the project has been to study advanced airframe and engine integration concepts to reduce community noise and fuel burn. In order to achieve this, complex wind tunnel experiments at both the NASA Langley Research Centers (LaRC) 14x22 and the Ames Research Centers 40x80 low-speed wind tunnel facilities were conducted on a Boeing Hybrid Wing Body (HWB) configuration. These wind tunnel tests entailed various entries to evaluate the propulsion airframe interference effects including aerodynamic performance and aeroacoustics. In order to assist these tests in producing high quality data with minimal hardware interference, extensive Computational Fluid Dynamic (CFD) simulations were performed for everything from sting design and placement for both the wing body and powered ejector nacelle systems to the placement of aeroacoustic arrays to minimize its impact on the vehicles aerodynamics. This paper will provide a high level summary of the CFD simulations that NASA performed in support of the model integration hardware design as well as some simulation guideline development based on post-test aerodynamic data. In addition, the paper includes details on how multiple CFD codes (OVERFLOW, STAR-CCM+, USM3D, and FUN3D) were efficiently used to provide timely insight into the wind tunnel experimental setup and execution.

  19. Engine Test Facility (ETF)

    Data.gov (United States)

    Federal Laboratory Consortium — The Air Force Arnold Engineering Development Center's Engine Test Facility (ETF) test cells are used for development and evaluation testing of propulsion systems for...

  20. TRISTAR I: Evaluation Methods for Testing Head-Up Display (HUD) Flight Symbology

    National Research Council Canada - National Science Library

    Newman, R

    1995-01-01

    A piloted head up display (HUD) flight symbology study (TRISTAR) measuring pilot task performance was conducted at the NASA Ames Research Center by the Tri-Service Flight Symbology Working Group (FSWO...

  1. Thyroid Function Tests

    Science.gov (United States)

    ... Home » Thyroid Function Tests Leer en Español Thyroid Function Tests FUNCTION HOW DOES THE THYROID GLAND FUNCTION? ... Cancer Thyroid Nodules in Children and Adolescents Thyroid Function Tests Resources Thyroid Function Tests Brochure PDF En ...

  2. CEA (Carcinoembryonic Antigen) Test

    Science.gov (United States)

    ... Gene Mutations Testing Cytomegalovirus (CMV) Tests D-dimer Dengue Fever Testing Des-gamma-carboxy prothrombin (DCP) DHEAS ... Glance Why Get Tested? Primarily to monitor cancer treatment, including response to therapy and recurrence; as an ...

  3. Blood Test: Bilirubin

    Science.gov (United States)

    ... Videos for Educators Search English Español Blood Test: Bilirubin KidsHealth / For Parents / Blood Test: Bilirubin What's in ... liver or kidneys) is working. What Is a Bilirubin Test? A bilirubin test measures how much bilirubin ...

  4. Catecholamine blood test

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003561.htm Catecholamine blood test To use the sharing features on this page, ... measured with a urine test than with a blood test. How the Test is Performed A blood sample ...

  5. Anthrax blood test

    Science.gov (United States)

    Anthrax serology test; Antibody test for anthrax; Serologic test for B. anthracis ... This test may be performed when the health care provider suspects you have anthrax infection. The bacteria that cause ...

  6. Myoglobin blood test

    Science.gov (United States)

    Serum myoglobin; Heart attack - myoglobin blood test; Myositis - myoglobin blood test; Rhabdomyolysis - myoglobin blood test ... too high, it can damage the kidneys. This test is ordered when your health care provider suspects ...

  7. Blood sugar test

    Science.gov (United States)

    ... sugar; Blood sugar level; Fasting blood sugar; Glucose test; Diabetic screening - blood sugar test; Diabetes - blood sugar test ... The test may be done in the following ways: After you have not eaten anything for at least 8 ...

  8. Ketones urine test

    Science.gov (United States)

    Ketone bodies - urine; Urine ketones; Ketoacidosis - urine ketones test; Diabetic ketoacidosis - urine ketones test ... Urine ketones are usually measured as a "spot test." This is available in a test kit that ...

  9. Lactose tolerance tests

    Science.gov (United States)

    Hydrogen breath test for lactose tolerance ... Two common methods include: Lactose tolerance blood test Hydrogen breath test The hydrogen breath test is the preferred method. It measures the amount of hydrogen ...

  10. Test techniques for fracture mechanics testing

    International Nuclear Information System (INIS)

    Schwalbe, K.H.

    1980-01-01

    Test methods for fracture mechanics tests are described. Two groups of techniques are distinguished: Those for measurement of stable crack growth and those for determination of the loading parameters. (orig.) [de

  11. To test or not to test

    DEFF Research Database (Denmark)

    Rochon, Justine; Gondan, Matthias; Kieser, Meinhard

    2012-01-01

    Background: Student's two-sample t test is generally used for comparing the means of two independent samples, for example, two treatment arms. Under the null hypothesis, the t test assumes that the two samples arise from the same normally distributed population with unknown variance. Adequate...... control of the Type I error requires that the normality assumption holds, which is often examined by means of a preliminary Shapiro-Wilk test. The following two-stage procedure is widely accepted: If the preliminary test for normality is not significant, the t test is used; if the preliminary test rejects...... the null hypothesis of normality, a nonparametric test is applied in the main analysis. Methods: Equally sized samples were drawn from exponential, uniform, and normal distributions. The two-sample t test was conducted if either both samples (Strategy I) or the collapsed set of residuals from both samples...

  12. Materials testing 1985

    International Nuclear Information System (INIS)

    1985-01-01

    The following subjects were dealt with at the meeting: Testing with vibration loads; Hardness testing; Calibration of test devices and equipment; Test technique for compound materials; Vibration strength testing and expense of experiments; Solving problems in introducing forces into samples and components and process of ambulant materials testing. There are 17 separate abstracts from among 43 lectures. (orig./PW) [de

  13. 5-HIAA Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  14. Uric Acid Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  15. Direct Antiglobulin Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  16. CK-MB Test

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  17. Understanding Your Tests

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  18. Myasthenia Gravis Tests

    Science.gov (United States)

    ... PF4 Antibody Hepatitis A Testing Hepatitis B Testing Hepatitis C Testing HER2/neu Herpes Testing High-sensitivity C-reactive Protein (hs-CRP) Histamine Histone Antibody HIV Antibody and HIV Antigen (p24) HIV Antiretroviral Drug Resistance Testing, Genotypic HIV Viral Load HLA Testing HLA- ...

  19. Citric acid urine test

    Science.gov (United States)

    Urine - citric acid test; Renal tubular acidosis - citric acid test; Kidney stones - citric acid test; Urolithiasis - citric acid test ... No special preparation is necessary for this test. But the results ... test is usually done while you are on a normal diet. Ask your ...

  20. Navigation and flight director guidance for the NASA/FAA helicopter MLS curved approach flight test program

    Science.gov (United States)

    Phatak, A. V.; Lee, M. G.

    1985-01-01

    The navigation and flight director guidance systems implemented in the NASA/FAA helicopter microwave landing system (MLS) curved approach flight test program is described. Flight test were conducted at the U.S. Navy's Crows Landing facility, using the NASA Ames UH-lH helicopter equipped with the V/STOLAND avionics system. The purpose of these tests was to investigate the feasibility of flying complex, curved and descending approaches to a landing using MLS flight director guidance. A description of the navigation aids used, the avionics system, cockpit instrumentation and on-board navigation equipment used for the flight test is provided. Three generic reference flight paths were developed and flown during the test. They were as follows: U-Turn, S-turn and Straight-In flight profiles. These profiles and their geometries are described in detail. A 3-cue flight director was implemented on the helicopter. A description of the formulation and implementation of the flight director laws is also presented. Performance data and analysis is presented for one pilot conducting the flight director approaches.

  1. Hot-Fire Testing of 100 LB(sub F) LOX/LCH4 Reaction Control Engine at Altitude Conditions

    Science.gov (United States)

    Marshall, William M.; Kleinhenz, Julie E.

    2010-01-01

    Liquid oxygen/liquid methane (LO2/LCH4 ) has recently been viewed as a potential green propulsion system for both the Altair ascent main engine (AME) and reaction control system (RCS). The Propulsion and Cryogenic Advanced Development Project (PCAD) has been tasked by NASA to develop these green propellant systems to enable safe and cost effective exploration missions. However, experience with LO2/LCH4 as a propellant combination is limited, so testing of these systems is critical to demonstrating reliable ignition and performance. A test program of a 100 lb f reaction control engine (RCE) is underway at the Altitude Combustion Stand (ACS) of the NASA Glenn Research Center, with a focus on conducting tests at altitude conditions. These tests include a unique propellant conditioning feed system (PCFS) which allows for the inlet conditions of the propellant to be varied to test warm to subcooled liquid propellant temperatures. Engine performance, including thrust, c* and vacuum specific impulse (I(sub sp,vac)) will be presented as a function of propellant temperature conditions. In general, the engine performed as expected, with higher performance at warmer propellant temperatures but better efficiency at lower propellant temperatures. Mixture ratio effects were inconclusive within the uncertainty bands of data, but qualitatively showed higher performance at lower ratios.

  2. From Test Takers to Test Makers

    Science.gov (United States)

    Smith, Kari

    2009-01-01

    As a classroom teacher, Kari Smith realized that traditional objective tests don't always assess what students actually know. But tests are so deeply embedded in the education system that it would be difficult to do away with them entirely. Smith decided to make tests into learning tools. In this article, Smith describes three strategies for…

  3. CANFLEX fuel bundle strength tests (test report)

    International Nuclear Information System (INIS)

    Chang, Seok Kyu; Chung, C. H.; Kim, B. D.

    1997-08-01

    This document outlines the test results for the strength tests of the CANFLEX fuel bundle. Strength tests are performed to determine and verify the amount of the bundle shape distortion which is against the side-stops when the bundles are refuelling. There are two cases of strength test; one is the double side-stop test which simulates the normal bundle refuelling and the other is the single side-stop test which simulates the abnormal refuelling. the strength test specification requires that the fuel bundle against the side-stop(s) simulators for this test were fabricated and the flow rates were controlled to provide the required conservative hydraulic forces. The test rig conditions of 120 deg C, 11.2 MPa were retained for 15 minutes after the flow rate was controlled during the test in two cases, respectively. The bundle loading angles of number 13- number 15 among the 15 bundles were 67.5 deg CCW and others were loaded randomly. After the tests, the bundle shapes against the side-stops were measured and inspected carefully. The important test procedures and measurements were discussed as follows. (author). 5 refs., 22 tabs., 5 figs

  4. Test design requirements: Thermal conductivity probe testing

    International Nuclear Information System (INIS)

    Heath, R.E.

    1985-01-01

    This document establishes the test design requirements for development of a thermal conductivity probe test. The thermal conductivity probe determines in situ thermal conductivity using a line source transient heat conduction analysis. This document presents the rationale for thermal conductivity measurement using a thermal conductivity probe. A general test description is included. Support requirements along with design constraints are detailed to allow simple design of the thermal conductivity probe and test. The schedule and delivery requirements of the responsible test designer are also included. 7 refs., 1 fig

  5. Irradiation effects test series test IE-1 test results report

    International Nuclear Information System (INIS)

    Quapp, W.J.; Allison, C.M.; Farrar, L.C.; Mehner, A.S.

    1977-03-01

    The report describes the results of the first programmatic test in the Nuclear Regulatory Commission Irradiation Effects Test Series. This test (IE-1) used four 0.97m long PWR-type fuel rods fabricated from previously irradiated Saxton fuel. The objectives of this test were to evaluate the effect of fuel pellet density on pellet-cladding interaction during a power ramp and to evaluate the influence of the irradiated state of the fuel and cladding on rod behavior during film boiling operation. Data are presented on the behavior of irradiated fuel rods during steady-state operation, a power ramp, and film boiling operation. The effects of as-fabricated gap size, as-fabricated fuel density, rod power, and power ramp rate on pellet-cladding interaction are discussed. Test data are compared with FRAP-T2 computer model predictions, and comments on the consequences of sustained film boiling operation on irradiated fuel rod behavior are provided

  6. Design of a piezoelectric shaker for centrifuge testing

    Science.gov (United States)

    Canclini, J. G.; Henderson, J. M.

    1979-01-01

    The design of a prototype piezoelectric shaker and its development to date is described. Although certain design problems remain to be solved, the piezoelectric system shows promise for adaptation to a larger payload system, such as the proposed geotechnical centrifuge at the Ames Research Center.

  7. The Stimulus test stand

    International Nuclear Information System (INIS)

    Christofek, L.; Rapidis, P.; Reinhard, A.; Fermilab

    2005-01-01

    The Stimulus Test Stand was originally constructed and assembled for testing the SVX2 ASIC readout and then upgraded for SVX3 ASIC prototyping and testing. We have modified this system for SVX4 ASIC [1] prototype testing. We described the individual components below. Additional details for other hardware for SVX4 testing can be found in reference [2]. We provide a description of the Stimulus Test Stand used for prototype testing of the SVX4 chip

  8. Screening of potential lactobacilli antigenotoxicity by microbial and mammalian cell-based tests.

    Science.gov (United States)

    Caldini, G; Trotta, F; Villarini, M; Moretti, M; Pasquini, R; Scassellati-Sforzolini, G; Cenci, G

    2005-06-25

    Antigenotoxicity is considered an important property for probiotic lactobacilli. The ability of non probiotic lactobacilli from dairy products and starters to inhibit two reference genotoxins: 4-nitroquinoline-1-oxide and N-methyl-N'-nitro-N-nitrosoguanidine was evaluated. The study was carried out using short-term assays with different targets, such as procaryotic cells (SOS-Chromotest for genotoxicity in Escherichia coli and Ames test for mutagenicity in Salmonella typhimurium) and eucaryotic cells (Comet assay for genotoxicity in Caco-2 enterocytes). A high proportion of strains inhibiting 4-nitroquinoline-1-oxide activity was found in Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus delbrueckii subsp. bulgaricus and Lactobacillus plantarum. Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine activity occurred in only one L. acidophilus strain. All the strains with antigenotoxic properties also demonstrated antimutagenic activity and produced modifications in genotoxin spectroscopic profiles. Strain viability during and after genotoxin exposure was confirmed. Concordance of the results obtained with microbial and mammalian cell-based tests is underlined.

  9. Characterization of biological activity of cigarette smoke using in vitro tests

    International Nuclear Information System (INIS)

    Brooks, A.L.; Chen, B.T.; Mauderly, J.L.

    1988-01-01

    Studies were conducted to characterize the influence of exposure mode (whole-body continuous, nose only intermittent, nose-only continuous) on biological activity of cigarette smoke condensates. The mutagenic potency of the extracts was determined using Salmonella typhimurium tester strain TA-98 with and without the addition of S-9. The cytotoxicity of the cigarette smoke with and without the addition of S-9 was also determined using Chinese hamster ovary cells (CHO). Mutagenic activity was observed in the Ames test only after the addition of S-9. The optimum mutagenic activity was observed following addition of between 3 and 6% S-9. The average mutagenic potency, when cells were tested at the optimum level of S-9, was 1.5 revertants/mg extract. Cell killing by cigarette smoke extracts was the same for extracts derived from all three exposure modes. There was about 20% cell killing at concentrations of 300 mg extract/mL culture media. No differences were observed in either mutagenic or cytotoxic potency among the smoke extracts produced under different exposure conditions. (author)

  10. Power Effects on High Lift, Stability and Control Characteristics of the TCA Model Tested in the LaRC 14 x 22 Ft Wind Tunnel

    Science.gov (United States)

    Glessner, Paul T.

    1999-01-01

    The TCA-2 wind-tunnel test was the second in a series of planned tests utilizing the 5% Technology Concept Airplane (TCA) model. Each of the tests was planned to utilize the unique capabilities of the NASA Langley 14'x22' and the NASA Ames 12' test facilities, in order to assess specific aspects of the high lift and stability and control characteristics of the TCA configuration. However, shortly after the completion of the TCA-1 test, an early projection of the Technology Configuration (TC) identified the need for several significant changes to the baseline TCA configuration. These changes were necessary in order to meet more stringent noise certification levels, as well as, to provide a means to control dynamic structural modes. The projected changes included a change to the outboard wing (increased aspect ratio and lower sweep) and a reconfiguration of the longitudinal control surfaces to include a medium size canard and a reduced horizontal tail. The impact of these proposed changes did not affect the TCA-2 test, because it was specifically planned to address power effects on the empennage and a smaller horizontal tail was in the plan to be tested. However, the focus of future tests was reevaluated and the emphasis was shifted away from assessment of TCA specific configurations to a more general assessment of configurations that encompass the projected design space for the TC.

  11. CSF-VDRL test

    Science.gov (United States)

    ... test - CSF; Neurosyphilis - VDRL Images CSF test for syphilis References Chernecky CC, Berger BJ. Venereal disease research laboratory test (VDRL), test, cerebrospinal fluid – specimen. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures . 6th ed. St Louis, MO: Elsevier Saunders; ...

  12. CO2 blood test

    Science.gov (United States)

    Bicarbonate test; HCO3-; Carbon dioxide test; TCO2; Total CO2; CO2 test - serum; Acidosis - CO2; Alkalosis - CO2 ... Many medicines can interfere with blood test results. Your health ... need to stop taking any medicines before you have this test. DO ...

  13. Tonopah Test Range - Index

    Science.gov (United States)

    Capabilities Test Operations Center Test Director Range Control Track Control Communications Tracking Radars Photos Header Facebook Twitter YouTube Flickr RSS Tonopah Test Range Top TTR_TOC Tonopah is the testing range of choice for all national security missions. Tonopah Test Range (TTR) provides research and

  14. Results and Interpretation of the WFRD ELS Distillation Down-Select Test Data

    Science.gov (United States)

    Delzeit, Lance Dean; Flynn, Michael; Carter, Layne; Long, David A.

    2010-01-01

    Testing of the Wiped-film Rotating-disk (WFRD) evaporator was conducted in support of the Exploration Life Support Distillation Down-Select Test. The WFRD was constructed at NASA Ames Research Center (ARC) and tested at NASA Marshall Space Flight Center (MSFC). The WFRD was delivered to MSFC in September 2009, and testing of solution #1 and solution #2 immediately following. Solution #1 was composed of humidity condensate and urine, including flush water and pretreatment chemicals. Solution #2 was composed of hygiene water, humidity condensate, and urine, including flush water and pretreatment chemicals. During the testing, the operational parameters of the WFRD were recorded and samples of the feed, brine, and product were collected and analyzed. The steady-state results of processing 414L of feed solution #1 and 1283L of feed solution #2 demonstrated that running the WFRD at a brine temperature of 50 C gave an average production rate of 16.7 L/hr. The specific energy consumption was 80.5W-hr/L. Data Analysis shows that the water recovery rates were 94% and 91%, respectively. The total mass of the WFRD as delivered to MSFC was 300 Kg. The volume of the tests stand rack was 1m width x 0.7m depth x 1.9m height or 1.5 cu m of which about half of the total volume is occupied by equipment. Chemical analysis of the distillate showed an average TOC of 20ppm, a pH of 3.5, and a conductivity of 98 mho/cm. The conductivity of the distillate, compared to the feed, decreased by 98.9%., the total ion concentration decreased by 99.6%, the total organics decreased 98.6%, and the metals were at or below detection limits

  15. Rail Impact Testing. Test Operations Procedure (TOP)

    Science.gov (United States)

    2008-09-15

    impact test. The rail impact test is used to verify structural integrity of the test item and the adequacy of the tie-down system and tie-down...strength of provisions, connection and supporting structural frame, paragraph 5.2.3 ** Superscript...parts, to include outriggers and booms) without advanced approval by SDDCTEA. Torque nuts on wire rope clips to their correct value. Torque cable

  16. Tractor accelerated test on test rig

    Directory of Open Access Journals (Sweden)

    M. Mattetti

    2013-09-01

    Full Text Available The experimental tests performed to validate a tractor prototype before its production, need a substantial financial and time commitment. The tests could be reduced using accelerated tests able to reproduce on the structural part of the tractor, the same damage produced on the tractor during real life in a reduced time. These tests were usually performed reproducing a particular harsh condition a defined number of times, as for example using a bumpy road on track to carry out the test in any weather condition. Using these procedures the loads applied on the tractor structure are different with respect to those obtained during the real use, with the risk to apply loads hard to find in reality. Recently it has been demonstrated how, using the methodologies designed for cars, it is possible to also expedite the structural tests for tractors. In particular, automotive proving grounds were recently successfully used with tractors to perform accelerated structural tests able to reproduce the real use of the machine with an acceleration factor higher than that obtained with the traditional methods. However, the acceleration factor obtained with a tractor on proving grounds is in any case reduced due to the reduced speed of the tractors with respect to cars. In this context, the goal of the paper is to show the development of a methodology to perform an accelerated structural test on a medium power tractor using a 4 post test rig. In particular, several proving ground testing conditions have been performed to measure the loads on the tractor. The loads obtained were then edited to remove the not damaging portion of signals, and finally the loads obtained were reproduced in a 4 post test rig. The methodology proposed could be a valid alternative to the use of a proving ground to reproduce accelerated structural tests on tractors.

  17. Genotoxicity of drinking water treated with different disinfectants and effects of disinfection conditions detected by umu-test.

    Science.gov (United States)

    Nie, Xuebiao; Liu, Wenjun; Zhang, Liping; Liu, Qing

    2017-06-01

    The genotoxicity of drinking water treated with 6 disinfection methods and the effects of disinfection conditions were investigated using the umu-test. The pretreatment procedure of samples for the umu-test was optimized for drinking water analysis. The results of the umu-test were in good correlation with those of the Ames-test. The genotoxicity and production of haloacetic acids (HAAs) were the highest for chlorinated samples. UV+chloramination is the safest disinfection method from the aspects of genotoxicity, HAA production and inactivation effects. For chloramination, the effects of the mass ratio of Cl 2 to N of chloramine on genotoxicity were also studied. The changes of genotoxicity were different from those of HAA production, which implied that HAA production cannot represent the genotoxic potential of water. The genotoxicity per chlorine decay of chlorination and chloramination had similar trends, indicating that the reaction of organic matters and chlorine made a great contribution to the genotoxicity. The results of this study are of engineering significance for optimizing the operation of waterworks. Copyright © 2016. Published by Elsevier B.V.

  18. Mutagenicity in drug development: interpretation and significance of test results.

    Science.gov (United States)

    Clive, D

    1985-03-01

    The use of mutagenicity data has been proposed and widely accepted as a relatively fast and inexpensive means of predicting long-term risk to man (i.e., cancer in somatic cells, heritable mutations in germ cells). This view is based on the universal nature of the genetic material, the somatic mutation model of carcinogenesis, and a number of studies showing correlations between mutagenicity and carcinogenicity. An uncritical acceptance of this approach by some regulatory and industrial concerns is over-conservative, naive, and scientifically unjustifiable on a number of grounds: Human cancers are largely life-style related (e.g., cigarettes, diet, tanning). Mutagens (both natural and man-made) are far more prevalent in the environment than was originally assumed (e.g., the natural bases and nucleosides, protein pyrolysates, fluorescent lights, typewriter ribbon, red wine, diesel fuel exhausts, viruses, our own leukocytes). "False-positive" (relative to carcinogenicity) and "false-negative" mutagenicity results occur, often with rational explanations (e.g., high threshold, inappropriate metabolism, inadequate genetic endpoint), and thereby confound any straightforward interpretation of mutagenicity test results. Test battery composition affects both the proper identification of mutagens and, in many instances, the ability to make preliminary risk assessments. In vitro mutagenicity assays ignore whole animal protective mechanisms, may provide unphysiological metabolism, and may be either too sensitive (e.g., testing at orders-of-magnitude higher doses than can be ingested) or not sensitive enough (e.g., short-term treatments inadequately model chronic exposure in bioassay). Bacterial systems, particularly the Ames assay, cannot in principle detect chromosomal events which are involved in both carcinogenesis and germ line mutations in man. Some compounds induce only chromosomal events and little or no detectable single-gene events (e.g., acyclovir, caffeine

  19. Color vision test

    Science.gov (United States)

    ... present from birth) color vision problems: Achromatopsia -- complete color blindness , seeing only shades of gray Deuteranopia -- difficulty telling ... Vision test - color; Ishihara color vision test Images Color blindness tests References Bowling B. Hereditary fundus dystrophies. In: ...

  20. Kidney function tests

    Science.gov (United States)

    Kidney function tests are common lab tests used to evaluate how well the kidneys are working. Such tests include: ... Oh MS, Briefel G. Evaluation of renal function, water, electrolytes ... and Management by Laboratory Methods . 23rd ed. Philadelphia, ...

  1. Liver Function Tests

    Science.gov (United States)

    ... digest food, store energy, and remove poisons. Liver function tests are blood tests that check to see ... as hepatitis and cirrhosis. You may have liver function tests as part of a regular checkup. Or ...

  2. Home blood sugar testing

    Science.gov (United States)

    Diabetes - home glucose testing; Diabetes - home blood sugar testing ... Usual times to test your blood sugar are before meals and at bedtime. Your provider may ask you to check your blood sugar 2 hours after a meal or ...

  3. Teratology testing under REACH.

    Science.gov (United States)

    Barton, Steve

    2013-01-01

    REACH guidelines may require teratology testing for new and existing chemicals. This chapter discusses procedures to assess the need for teratology testing and the conduct and interpretation of teratology tests where required.

  4. Celiac Disease Tests

    Science.gov (United States)

    ... diet When To Get Tested? When you have symptoms suggesting celiac disease, such as chronic diarrhea, abdominal pain, anemia , and ... Celiac tests are usually ordered for people with symptoms suggesting celiac disease, including anemia and abdominal pain. Sometimes celiac testing ...

  5. Aviation Flight Test

    Data.gov (United States)

    Federal Laboratory Consortium — Redstone Test Center provides an expert workforce and technologically advanced test equipment to conduct the rigorous testing necessary for U.S. Army acquisition and...

  6. Mark 1 Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Mark I Test Facility is a state-of-the-art space environment simulation test chamber for full-scale space systems testing. A $1.5M dollar upgrade in fiscal year...

  7. Growth hormone suppression test

    Science.gov (United States)

    ... Acromegaly - blood test; Gigantism - blood test Images Blood test References Kaiser U, Ho KKY. Pituitary physiology and diagnostic evaluation. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology . 13th ed. Philadelphia, PA: Elsevier; ...

  8. Lactose Tolerance Tests

    Science.gov (United States)

    ... Plasma Free Metanephrines Platelet Count Platelet Function Tests Pleural Fluid Analysis PML-RARA Porphyrin Tests Potassium Prealbumin ... of these, the person tested is given a liquid to drink that contains a standard amount of ...

  9. Thyroid Diseases Tests

    Science.gov (United States)

    ... Gene Mutations Testing Cytomegalovirus (CMV) Tests D-dimer Dengue Fever Testing Des-gamma-carboxy prothrombin (DCP) DHEAS ... newborn blood screening programs since early detection and treatment can minimize long-term damage. Hashimoto thyroiditis : the ...

  10. What Is Diagnostic Testing?

    Science.gov (United States)

    ... your family Plan for the future Insurance and financial planning Transition for children Emergency preparedness Testing & Services Testing ... Support Genetic Disease Information Find a Support Group Financial Planning Who Should I Tell? Genetic Testing & Counseling Compensation ...

  11. Tests for H. pylori

    Science.gov (United States)

    ... ulcers and many cases of stomach inflammation (chronic gastritis). How the Test is Performed There are several ... treating bleeding, or making sure there is no cancer. Why the Test is Performed Testing is most ...

  12. BUN - blood test

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003474.htm BUN - blood test To use the sharing features on this page, ... for the Test Many medicines can interfere with blood test results. Your health care provider will tell you ...

  13. Porphyrins - blood test

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003372.htm Porphyrins blood test To use the sharing features on this page, ... blood or the urine . This article discusses the blood test. How the Test is Performed A blood sample ...

  14. Renin blood test

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003698.htm Renin blood test To use the sharing features on this page, ... renin test measures the level of renin in blood. How the Test is Performed A blood sample is needed . How ...

  15. Prolactin blood test

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003718.htm Prolactin blood test To use the sharing features on this page, ... test measures the amount of prolactin in the blood. How the Test is Performed A blood sample is needed . How ...

  16. Large Rotor Test Apparatus

    Data.gov (United States)

    Federal Laboratory Consortium — This test apparatus, when combined with the National Full-Scale Aerodynamics Complex, produces a thorough, full-scale test capability. The Large Rotor Test Apparatus...

  17. Ketones blood test

    Science.gov (United States)

    Acetone bodies; Ketones - serum; Nitroprusside test; Ketone bodies - serum; Ketones - blood; Ketoacidosis - ketones blood test ... fat cells break down in the blood. This test is used to diagnose ketoacidosis . This is a ...

  18. Dexamethasone suppression test

    Science.gov (United States)

    DST; ACTH suppression test; Cortisol suppression test ... During this test, you will receive dexamethasone. This is a strong man-made (synthetic) glucocorticoid medicine. Afterward, your blood is drawn ...

  19. Bone mineral density test

    Science.gov (United States)

    BMD test; Bone density test; Bone densitometry; DEXA scan; DXA; Dual-energy x-ray absorptiometry; p-DEXA; Osteoporosis - BMD ... need to undress. This scan is the best test to predict your risk of fractures, especially of ...

  20. Assessment and Testing.

    Science.gov (United States)

    Clapham, Caroline

    2000-01-01

    Explores the term "applied linguistics" and discusses the role of language testing within this discipline, the relationship between testing and teaching, and the relationship between testing and assessment (Author/VWL)