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Sample records for american house dust

  1. American Houses

    Institute of Scientific and Technical Information of China (English)

    张梦华

    2004-01-01

    American houses usually have private kitchens,a living room and sometimes separate areas for eating and watching television,A house usually has its own mailbox,a yard with plants or perhaps a lawn,and a place to store garbage out of sight.

  2. Effects of five insect growth regulators on laboratory populations of the North American house-dust mite, Dermatophagoides farinae.

    Science.gov (United States)

    Downing, A S; Wright, C G; Farrier, M H

    1990-08-01

    The potential of insect growth regulators (methoprene, hydroprene, fenoxycarb, diflubenzuron and triflumuron) to control populations of the North American house-dust mite Dermatophagoides farinae (Hughes) was assessed in laboratory bioassays. Methoprene was most effective at suppressing population growth, especially at concentrations of 1.0% (10,000 ppm) and 5.0% (5000 ppm) active ingredient. Hydroprene, structurally related to methoprene, also suppressed house-dust mite populations but not as consistently as methoprene. Fenoxycarb may be effective at controlling house-dust mites but at greater concentrations than were tested. Diflubenzuron and triflumuron, two chitin-synthesis inhibitors, failed to suppress mite numbers and may, in fact, stimulate reproduction in some cases. Almost all concentration of the insect growth regulators were shown to be ineffective when assayed 90 days after treatment. PMID:2226070

  3. PFASs in house dust

    OpenAIRE

    Nizzetto, Pernilla Bohlin; Hanssen, Linda; Herzke, Dorte

    2016-01-01

    NILU has, on behalf of the Norwegian Environment Agency, performed sampling and analysis of house dust from Norwegian households. The goal was to study concentration ranges, and variability between- and within-houses of anionic and volatile per- and polyfluorinated alkyl substances (PFASs), including the regulated PFOA, as well as for total extractable organic fluorine (TEOF). The sampling was done in six separate rooms in six different households. The analysis covered a suite of 20 targeted ...

  4. Radionuclides in house dust

    International Nuclear Information System (INIS)

    Discharges of radionuclides from the British Nuclear Fuel plc (BNFL) reprocessing plant at Sellafield in Cumbria have led to elevated concentrations radionuclides in the local environment. The major routes of exposure of the public are kept under review by the appropriate authorising Government departments and monitoring is carried out both by the departments and by BNFL itself. Recently, there has been increasing public concern about general environmental contamination resulting from the discharges and, in particular, about possible exposure of members of the public by routes not previously investigated in detail. One such postulated route of exposure that has attracted the interest of the public, the press and Parliament arises from the presence of radionuclides within houses. In view of this obvious and widespread concern, the Board has undertaken a sampling programme in a few communities in Cumbria to assess the radiological significance of this source of exposure. From the results of our study, we conclude that, although radionuclides originating rom the BNFL site can be detected in house dust, this source of contamination is a negligible route of exposure for members of the public in West Cumbria. This report presents the results of the Board's study of house dust in twenty homes in Cumbria during the spring and summer of 1984. A more intensive investigation is being carried out by Imperial College. (author)

  5. House Dust Mite Respiratory Allergy

    DEFF Research Database (Denmark)

    Calderón, Moisés A; Kleine-Tebbe, Jörg; Linneberg, Allan;

    2015-01-01

    Although house dust mite (HDM) allergy is a major cause of respiratory allergic disease, specific diagnosis and effective treatment both present unresolved challenges. Guidelines for the treatment of allergic rhinitis and asthma are well supported in the literature, but specific evidence on the...

  6. Radionuclides in house dust

    CERN Document Server

    Fry, F A; Green, N; Hammond, D J

    1985-01-01

    Discharges of radionuclides from the British Nuclear Fuel plc (BNFL) reprocessing plant at Sellafield in Cumbria have led to elevated concentrations radionuclides in the local environment. The major routes of exposure of the public are kept under review by the appropriate Government departments and monitoring is carried out both by the departments and by BNFL itself. Recently, there has been increasing public concern about general environmental contamination resulting from the discharges and, in particular, about possible exposure of members of the public by routes not previously investigated in detail. One such postulated route of exposure that has attracted the interest of the public, the press and Parliament arises from the presence of radionuclides within houses. In view of this obvious and widespread concern, the Board has undertaken a sampling programme in a few communities in Cumbria to assess the radiological significance of this source of exposure. From the results of our study, we conclude that, alt...

  7. THE MAIN CULPRIT IN ALLERGIC RHINITIS - HOUSE DUST OR HOUSE DUST MITE

    OpenAIRE

    Abhey

    2015-01-01

    Allergic rhinitis especially perennial type makes life miserable for the patient. House dust mite is one of the major players causing it. This study is to compare the allergen i n city of house dust mite versus house dust and evaluate any cross - allergenicity between them. STUDY DESIGN: Prospective study in a tertiary referral ...

  8. THE MAIN CULPRIT IN ALLERGIC RHINITIS - HOUSE DUST OR HOUSE DUST MITE

    Directory of Open Access Journals (Sweden)

    Abhey

    2015-10-01

    Full Text Available Allergic rhinitis especially perennial type makes life miserable for the patient. House dust mite is one of the major players causing it. This study is to compare the allergen i n city of house dust mite versus house dust and evaluate any cross - allergenicity between them. STUDY DESIGN: Prospective study in a tertiary referral hospital. MATERIALS & METHODS: Forty patients of allergic rhinitis and well matched controls were subjected to intradermal skin tests to house dust and house dust mite allergen. The skin tests were graded as per standard norms and the responses matched after correlating with different parameters. Statistical analysis was done and the results evaluated. RESULTS: House dust mite was the main allergen, as compared to house dust, responsible for causing allergic rhinitis. The allergen reactivity potential of house dust mite was significantly more as compared to house dust. And, as such there was no statistically significant cross - allergenicity between the two groups. CONCLUSION: House dust mite rather than house dust is the main culprit in causing allergic rhinitis. Hence, precautionary and preventive measures to control the exposure to house dust mite can be undertaken

  9. Airborne microorganisms and dust from livestock houses

    OpenAIRE

    Zhao, Y.; Aarnink, A.J.A.; Jong, de, M.C.M.; Groot Koerkamp, P.W.G.

    2011-01-01

    The objective of this study was to evaluate the efficiencies and suitability of samplers for airborne microorganisms and dust, which could be used in practical livestock houses. Two studies were performed: 1) Testing impaction and cyclone pre-separators for dust sampling in livestock houses; 2) Determining sampling efficiencies of four bioaerosol samplers for bacteria and virus. Study 1. The overloading problem of the EU reference impaction pre-separator (IPS) was tested in layer houses and c...

  10. House dust mite control measures for asthma

    DEFF Research Database (Denmark)

    Gøtzsche, Peter C.; Johansen, Helle Krogh

    2008-01-01

    BACKGROUND: The major allergen in house dust comes from mites. Chemical, physical and combined methods of reducing mite allergen levels are intended to reduce asthma symptoms in people who are sensitive to house dust mites. OBJECTIVES: To assess the effects of reducing exposure to house dust mite...... antigens in the homes of people with mite-sensitive asthma. SEARCH STRATEGY: PubMed and The Cochrane Library (last searches Nov 2007), reference lists. SELECTION CRITERIA: Randomised trials of mite control measures vs placebo or no treatment in people with asthma known to be sensitive to house dust mites......), the standardised mean difference was 0.00 (95% confidence interval (CI) -0.10 to 0.10). There were no statistically significant differences either in number of patients improved (relative risk 1.01, 95% CI 0.80 to 1.27), asthma symptom scores (standardised mean difference -0.04, 95% CI -0.15 to 0...

  11. American Housing Survey (AHS)

    Data.gov (United States)

    Department of Housing and Urban Development — The AHS is the largest, regular national housing sample survey in the United States. The U.S. Census Bureau conducts the AHS to obtain up-to-date housing statistics...

  12. Lead in Chinese villager house dust

    Science.gov (United States)

    Bi, Xiangyang; Liu, Jinling; Han, Zhixuan

    2016-04-01

    House dust has been recognized as an important contributor to children's blood Pb. Here we conducted a comprehensive study to investigate geographical variation of Pb in Chinese villager house dust. The concentrations of Pb in 477 house dust samples collected from twenty eight areas throughout China varied from 12 to 2510 mg/kg, with geometric mean and median concentration of 54 mg/kg and 42 mg/kg, respectively. The median Pb concentrations in different geographical areas ranged from 16 (Zhangjiakou, Hebei) to 195 mg/kg (Loudi, Hunan). The influences of outdoor soil Pb concentrations, dates of construction, house decorative materials, heating types, and site specific pollution on Pb concentrations in house dust were evaluated. No correlations were found between the house dust Pb concentrations and the age of houses, as well as house decorative materials. Whereas outdoor soil, coal combustion, and site specific pollution may be potential Pb sources. The results of scanning electron microscopy (SEM) showed that Pb bearing particles appeared as cylindrical, flaky and irregular aggregates with the particle size ranging from about 10 to 800 μm. The energy dispersive X-ray microanalysis (EDX) suggested that Pb in the dust particles may be associated with calcium compounds. But the major fraction of Pb in the household dust samples was found to be strongly bound to Fe-Mn oxide phases (37%) while Pb present in minor fractions individually making up between 14 and 18% was characterized in falling order as residual, carbonate, organic/sulphide and exchangeable fractions by the sequential extraction method applied. Bioaccessible Pb making up an average proportion of 53% in the household dusts was significantly correlated to the Fe-Mn oxide phases of Pb.

  13. Respiratory allergy caused by house dust mites

    DEFF Research Database (Denmark)

    Calderón, Moisés A; Linneberg, Allan; Kleine-Tebbe, Jörg;

    2015-01-01

    The house dust mite (HDM) is a major perennial allergen source and a significant cause of allergic rhinitis and allergic asthma. However, awareness of the condition remains generally low. This review assesses the links between exposure to HDM, development of the allergic response, and pathologic...... consequences in patients with respiratory allergic diseases. We investigate the epidemiology of HDM allergy to explore the interaction between mites and human subjects at the population, individual, and molecular levels. Core and recent publications were identified by using "house dust mite" as a key search...... the literature confound estimates, indicating the need for greater standardization in epidemiologic research. Exposure to allergens depends on multiple ecological strata, including climate and mite microhabitats within the domestic environment, with the latter providing opportunity for intervention...

  14. House dust mite control measures for asthma: systematic review

    DEFF Research Database (Denmark)

    Gøtzsche, Peter C.; Johansen, Helle Krogh

    2008-01-01

    The major allergen in house dust comes from mites. We performed a systematic review of the randomized trials that had assessed the effects of reducing exposure to house dust mite antigens in the homes of people with mite-sensitive asthma, and had compared active interventions with placebo or no...

  15. American Housing Survey (AHS) 2011

    Data.gov (United States)

    Department of Housing and Urban Development — The AHS is the largest, regular national housing sample survey in the United States. The U.S. Census Bureau conducts the AHS to obtain up-to-date housing statistics...

  16. A BIOPHYSIOCHEMICAL ANALYSIS OF SETTLED LIVESTOCK AND POULTRY HOUSING DUSTS

    OpenAIRE

    Carresse Gerald; Christi McPherson; Tha’Mes McDaniel; Zhigang Xu; Bryce Holmes; Leonard Williams; Niki Whitley; Jenora Turner Waterman

    2014-01-01

    The levels and composition of agricultural dusts are influenced by animal species, production strategy, housing type and ventilation efficiency. Agricultural dust within animal houses is complex and consists of feed particles, microbes and their products, dander, fecal matter, gases, metals and other organic and inorganic components. Livestock and poultry production facilities may be categorized as confinement, semi-confinement or pasture-based. Characterization of animal husbandry building d...

  17. Bioaccessibility of Fipronil Sorbed to Soil and House Dust

    Science.gov (United States)

    Fipronil is a phenylpyrazole insecticide with uses ranging from soil treatment, to the control of household pests and ectoparasites on pets. Soils and house dusts readily sorb fipronil and when these soils and dusts are ingested, the fipronil may become bioaccessible for uptake ...

  18. House dust mite allergy: environment evaluation and disease prevention

    OpenAIRE

    Yu, Sheng-Jie; Liao, En-Chih; Tsai, Jaw-Ji

    2014-01-01

    There are two groups of dust mites, house dust mites (HDMs) and storage mites (SMs), that have been identified in the household environment. Both could induce airway inflammation through activation of innate and adaptive immunity and lead to asthma. In order to monitor environmental dust mite infestation, different methods can be used to detect their presence, such as the use of floating methods, monoclonal antibodies, and nanostructured biosensor. SM could be identified in the storage room, ...

  19. House dust in seven Danish offices

    Science.gov (United States)

    Mølhave, L.; Schneider, T.; Kjærgaard, S. K.; Larsen, L.; Norn, S.; Jørgensen, O.

    Floor dust from Danish offices was collected and analyzed. The dust was to be used in an exposure experiment. The dust was analyzed to show the composition of the dust which can be a source of airborne dust indoors. About 11 kg of dust from vacuum cleaner bags from seven Danish office buildings with about 1047 occupants (12 751 m 2) was processed according to a standardized procedure yielding 5.5 kg of processed bulk dust. The bulk dust contained 130.000-160.000 CFU g -1 microorganisms and 71.000-90.000 CFU g -1 microfungi. The content of culturable microfungi was 65-123 CFU 30 g -1 dust. The content of endotoxins ranged from 5.06-7.24 EU g -1 (1.45 ng g -1 to 1.01 ng g -1). Allergens (ng g -1) were from 147-159 (Mite), 395-746 (dog) and 103-330 (cat). The macro molecular organic compounds (the MOD-content) varied from 7.8-9.8 mg g -1. The threshold of release of histamine from basophil leukocytes provoked by the bulk dust was between 0.3 and 1.0 mg ml -1. The water content was 2% (WGT) and the organic fraction 33%. 6.5-5.9% (dry) was water soluble. The fiber content was less than 0.2-1.5% (WGT) and the desorbable VOCs was 176-319 μg g -1. Most of the VOC were aldehydes. However, softeners for plastic (DBP and DEHP) were present. The chemical composition includes human and animal skin fragments, paper fibers, glass wool, wood and textilefibers and inorganic and metal particles. The sizes ranged from 0.001-1 mm and the average specific density was 1.0 g m -3. The bulk dust was resuspended and injected into an exposure chamber. The airborne dust was sampled and analyzed to illustrate the exposures that can result from sedimented dirt and dust. The airborne dust resulting from the bulk dust reached concentrations ranging from 0.26-0.75 mg m -3 in average contained 300-170 CFU m -3. The organic fraction was from 55-70% and the water content about 2.5% (WGT). The content of the dust was compared to the similar results reported in the literature and its toxic potency is

  20. A BIOPHYSIOCHEMICAL ANALYSIS OF SETTLED LIVESTOCK AND POULTRY HOUSING DUSTS

    Directory of Open Access Journals (Sweden)

    Carresse Gerald

    2014-01-01

    Full Text Available The levels and composition of agricultural dusts are influenced by animal species, production strategy, housing type and ventilation efficiency. Agricultural dust within animal houses is complex and consists of feed particles, microbes and their products, dander, fecal matter, gases, metals and other organic and inorganic components. Livestock and poultry production facilities may be categorized as confinement, semi-confinement or pasture-based. Characterization of animal husbandry building dust will provide insight into understanding exposures experienced by animals, workers and farm visitors. The goal was to characterize biophysiochemical features of livestock dusts from swine, small ruminant, equine, poultry and cattle husbandry units. Settled dust samples were collected from livestock and poultry housing units at the University Farm and other livestock farms across the state. Morphological features were determined by electron microscopy and gravimetry. Biochemical evaluation consisted of pH determination and trace metal detection via mass spectrometry. Biological assessment centered on bacterial characterization via selective media, DNA analysis and endotoxin quantitation. Morphological analyses revealed higher levels of respirable and thoracic particles in poultry, swine, small ruminant and equine units compared to the dairy unit (p<0.01. Dusts were slightly acidic with the exception of the NCAT small ruminant unit (p<0.05. Dust endotoxin levels were consistent and bacterial species detected include Listeria and Escherichia coli. These findings suggest animal husbandry buildings harbor higher levels of smaller respirable and thoracic dust particles compared to inhalable particles. This information may be helpful in understanding dust exposures experienced by animals, farmers and agricultural workers.

  1. Mite antigen and allergen contents of house dust samples.

    OpenAIRE

    Ishii, Akira; Yatani,Toshiko; Abe, Tatsuya; Go,Han Jin

    1988-01-01

    The house dust mite (Dermatophagoides pteronyssinus) antigen and allergen contents were measured by enzyme-linked immunosorbent assay (ELISA) with enzyme-labelled anti-human IgE and anti-mite rabbit IgG antibodies. Antigen content was high in dust samples from homes of patients with allergy but not in samples from homes of patients with Kawasaki disease or of normal control subjects. Allergen content was high in dust samples from homes of Kawasaki disease patients. However, the values overlap...

  2. Association of House Dust Allergen Concentrations With Residential Conditions in City and in Rural Houses

    OpenAIRE

    Wardzyńska, Aleksandra; Majkowska-Wojciechowska, Barbara; Pełka, Jolanta; Korzon, Leszek; Kaczała, Magdalena; Jarzębska, Marzanna; Gwardys, Tomasz; Kowalski, Marek L.

    2012-01-01

    Background The aim of the study was to evaluate the relationship between house dust mite, cat and dog allergen levels with household characteristics in the houses of children living in urban and rural areas in central Poland. Methods Dust samples were collected from 141 urban and 191 rural houses. Der f1 + Der p1, Can f 1, and Fel d1 levels were measured and associated with residential conditions and atopy-related health outcomes assessed by clinical examination and skin prick testing. Result...

  3. Relevancy of human exposure via house dust to the contaminants lead and asbestos

    NARCIS (Netherlands)

    Oomen AG; Lijzen JPA; SIR; LER

    2004-01-01

    The present report addresses the issues whether house dust is likely to contribute substantially to the exposure of humans, in particular for the contaminants lead and asbestos. House dust consists for 30-70% of soil material, indicating that contaminated soil can lead to contaminated house dust. It

  4. Immunoinformatics and Similarity Analysis of House Dust Mite Tropomyosin

    OpenAIRE

    Mohammad Mehdi Ranjbar; Sedigheh Nabian; Nayeb Ali Ahmadi; Khodayar Ghorban; Alireza Sazmand; Maryam Dadmanesh; Seyed Hossein Hekmatimoghaddam

    2015-01-01

    Background: Dermatophagoides farinae and Dermatophagoides pteronyssinus are house dust mites (HDM) that they cause severe asthma and allergic symptoms. Tropomyosin protein plays an important role in mentioned immune and allergic reactions to HDMs. Here, tropomyosin protein from Dermatophagoides spp. was comprehensively screened in silico for its allergenicity, antigenicity and similarity/conservation.Materials and Methods: The amino acid sequences of D. farinae tropomyosin, D. pteronyssinus a...

  5. Non-targeted screening of house dust samples using accurate mass TOFMS

    Science.gov (United States)

    House dust exists as an environmental repository of chemicals to which we are exposed in our homes. A growing number of studies have targeted select persistent organic and inorganic pollutants found in house dust. Many have concluded that dust exists as an important human expos...

  6. Pheromonal Communication in the European House Dust Mite, Dermatophagoides pteronyssinus

    Directory of Open Access Journals (Sweden)

    Johannes L.M. Steidle

    2014-08-01

    Full Text Available Despite the sanitary importance of the European house dust mite Dermatophagoides pteronyssinus (Trouessart, 1897, the pheromonal communication in this species has not been sufficiently studied. Headspace analysis using solid phase micro extraction (SPME revealed that nerol, neryl formate, pentadecane, (6Z,9Z-6,9-heptadecadiene, and (Z-8-heptadecene are released by both sexes whereas neryl propionate was released by males only. Tritonymphs did not produce any detectable volatiles. In olfactometer experiments, pentadecane and neryl propionate were attractive to both sexes as well as to tritonymphs. (Z-8-heptadecene was only attractive to male mites. Therefore it is discussed that pentadecane and neryl propionate are aggregation pheromones and (Z-8-heptadecene is a sexual pheromone of the European house dust mite D. pteronyssinus. To study the potential use of pheromones in dust mite control, long-range olfactometer experiments were conducted showing that mites can be attracted to neryl propionate over distances of at least 50 cm. This indicates that mite pheromones might be useable to monitor the presence or absence of mites in the context of control strategies.

  7. Tetrabromobisphenol A in Indoor Dust from Houses and Internet Cafes

    Directory of Open Access Journals (Sweden)

    Ma. Pythias B. Espino

    2011-12-01

    Full Text Available Tetrabromobisphenol A or TBBPA is a widely used brominated flame retardant in modern materials such as electronic products, plastics and building materials. TBBPA can leach out of flame retardant-treated products during production, use, reuse, and final disposal of these consumer products. It has thus become a contemporary environmental contaminant. This study reports the levels of TBBPA in indoor dust from houses (n=4 and internet cafes (n=5 in Angono and Quezon City, in the Philippines. TBBPA in indoor dust was analyzed by ultrasonication-assisted hexane extraction and HPLC-UV determination. The instrument and method detection limits were 0.004 ng uL-1 and 1275 ng g-1, respectively. The standard calibration solutions ranged from 0.03 to 0.30 ng uL-1 (r2=0.9956. The extraction recovery was 78% (n=3. TBBPA was found in six of the nine indoor dust samples studied where the concentrations ranged from not detected to 4916 ng g-1. The occurrence and levels of TBBPA in indoor dusts are significant and suggest the need for further investigations especially in other microenvironments where people may be exposed to this contaminant.

  8. Associations between bacterial communities of house dust and infant gut

    International Nuclear Information System (INIS)

    The human gut is host to a diverse and abundant community of bacteria that influence health and disease susceptibility. This community develops in infancy, and its composition is strongly influenced by environmental factors, notably perinatal anthropogenic exposures such as delivery mode (Cesarean vs. vaginal) and feeding method (breast vs. formula); however, the built environment as a possible source of exposure has not been considered. Here we report on a preliminary investigation of the associations between bacteria in house dust and the nascent fecal microbiota from 20 subjects from the Canadian Healthy Infant Longitudinal Development (CHILD) Study using high-throughput sequence analysis of portions of the 16S rRNA gene. Despite significant differences between the dust and fecal microbiota revealed by Nonmetric Multidimensional Scaling (NMDS) analysis, permutation analysis confirmed that 14 bacterial OTUs representing the classes Actinobacteria (3), Bacilli (3), Clostridia (6) and Gammaproteobacteria (2) co-occurred at a significantly higher frequency in matched dust–stool pairs than in randomly permuted pairs, indicating an association between these dust and stool communities. These associations could indicate a role for the indoor environment in shaping the nascent gut microbiota, but future studies will be needed to confirm that our findings do not solely reflect a reverse pathway. Although pet ownership was strongly associated with the presence of certain genera in the dust for dogs (Agrococcus, Carnobacterium, Exiguobacterium, Herbaspirillum, Leifsonia and Neisseria) and cats (Escherichia), no clear patterns were observed in the NMDS-resolved stool community profiles as a function of pet ownership

  9. Associations between bacterial communities of house dust and infant gut

    Energy Technology Data Exchange (ETDEWEB)

    Konya, T.; Koster, B. [Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto (Canada); Maughan, H. [Department of Cell and Systems Biology, University of Toronto (Canada); Escobar, M. [Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto (Canada); Azad, M.B. [Department of Pediatrics, University of Alberta (Canada); Guttman, D.S. [Department of Cell and Systems Biology, University of Toronto (Canada); Sears, M.R. [Department of Medicine, McMaster University (Canada); Becker, A.B. [University of Manitoba (Canada); Brook, J.R. [Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto (Canada); Environment Canada (Canada); Takaro, T.K. [Faculty of Health Science, Simon Fraser University (Canada); Kozyrskyj, A.L. [Department of Pediatrics, University of Alberta (Canada); Scott, J.A., E-mail: james.scott@utoronto.ca [Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto (Canada)

    2014-05-01

    The human gut is host to a diverse and abundant community of bacteria that influence health and disease susceptibility. This community develops in infancy, and its composition is strongly influenced by environmental factors, notably perinatal anthropogenic exposures such as delivery mode (Cesarean vs. vaginal) and feeding method (breast vs. formula); however, the built environment as a possible source of exposure has not been considered. Here we report on a preliminary investigation of the associations between bacteria in house dust and the nascent fecal microbiota from 20 subjects from the Canadian Healthy Infant Longitudinal Development (CHILD) Study using high-throughput sequence analysis of portions of the 16S rRNA gene. Despite significant differences between the dust and fecal microbiota revealed by Nonmetric Multidimensional Scaling (NMDS) analysis, permutation analysis confirmed that 14 bacterial OTUs representing the classes Actinobacteria (3), Bacilli (3), Clostridia (6) and Gammaproteobacteria (2) co-occurred at a significantly higher frequency in matched dust–stool pairs than in randomly permuted pairs, indicating an association between these dust and stool communities. These associations could indicate a role for the indoor environment in shaping the nascent gut microbiota, but future studies will be needed to confirm that our findings do not solely reflect a reverse pathway. Although pet ownership was strongly associated with the presence of certain genera in the dust for dogs (Agrococcus, Carnobacterium, Exiguobacterium, Herbaspirillum, Leifsonia and Neisseria) and cats (Escherichia), no clear patterns were observed in the NMDS-resolved stool community profiles as a function of pet ownership.

  10. Structure of the house dust mite allergen Der f 2

    DEFF Research Database (Denmark)

    Johannessen, Birthe R; Skov, Lars; Kastrup, Jette S; Kristensen, Ole; Bolwig, Caroline; Larsen, Jørgen; Spangfort, Michael; Lund, Kaare; Gajhede, Michael

    2005-01-01

    The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of...... Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes....

  11. Dust Reduction in Broiler Houses by Spraying Rapeseed Oil

    OpenAIRE

    Aarnink, A.J.A.; Harn, van, J.; Hattum, van, J.; Zhao, Y.; Ogink, N.W.M.

    2011-01-01

    The effect of spraying rapeseed oil on the reduction of dust and ammonia concentrations and emissions, and on animal parameters was investigated in a dose-response study in a broiler house during three growing periods in four (round 1) or five rooms (rounds 2 and 3). The spraying rates varied per room, from 0 (control) to 24 mL oil m(-2) d(-1). Concentrations of PM10 and PM2.5 in incoming and outgoing air were measured. Production results (growth rate, feed intake, mortality rate) and foot-pa...

  12. Innate Immune Responses in House Dust Mite Allergy

    OpenAIRE

    Jacquet, Alain

    2013-01-01

    Sensitizations to house dust mites (HDM) trigger strong exacerbated allergen-induced inflammation of the skin and airways mucosa from atopic subjects resulting in atopic dermatitis as well as allergic rhinitis and asthma. Initially, the Th2-biased HDM allergic response was considered to be mediated only by allergen B- and T-cell epitopes to promote allergen-specific IgE production as well as IL-4, IL-5, and IL-13 to recruit inflammatory cells. But this general molecular model of HDM allergeni...

  13. Coal-tar-based parking lot sealcoat: An unrecognized source of PAH to settled house dust

    Science.gov (United States)

    Mahler, B.J.; Van Metre, P.C.; Wilson, J.T.; Musgrove, M.; Burbank, T.L.; Ennis, T.E.; Bashara, T.J.

    2010-01-01

    Despite much speculation, the principal factors controlling concentrations of polycyclic aromatic hydrocarbons (PAH) in settled house dust (SHD) have not yet been identified. In response to recent reports that dust from pavement with coaltar-based sealcoat contains extremely high concentrations of PAH, we measured PAH in SHD from 23 apartments and in dust from their associated parking lots, one-half of which had coal-tar-based sealcoat (CT). The median concentration of total PAH (T-PAH) in dust from CT parking lots (4760 ??g/g, n = 11) was 530 times higher than that from parking lots with other pavement surface types (asphalt-based sealcoat, unsealed asphalt, concrete [median 9.0 ??g/g, n = 12]). T-PAH in SHD from apartments with CT parking lots (median 129 ??g/g) was 25 times higher than that in SHD from apartments with parking lots with other pavement surface types (median 5.1 ??g/g). Presence or absence of CT on a parking lot explained 48% of the variance in log-transformed T-PAH in SHD. Urban land-use intensity near the residence also had a significant but weaker relation to T-PAH. No other variables tested, including carpeting, frequency of vacuuming, and indoor burning, were significant. ?? 2010 American Chemical Society.

  14. 77 FR 57544 - Native American Housing Assistance and Self-Determination Reauthorization Act of 1996: Request...

    Science.gov (United States)

    2012-09-18

    ... Americans. NAHASDA eliminated several separate assistance programs and replaced them with a single block... URBAN DEVELOPMENT 24 CFR Part 1000 Native American Housing Assistance and Self-Determination... Housing Block Grant program authorized by the Native American Housing Assistance and...

  15. Effect of mattress and pillow encasings on children with asthma and house dust mite allergy

    DEFF Research Database (Denmark)

    Halken, Susanne; Høst, Arne; Niklassen, Ulla; Hansen, Lars G; Nielsen, Frank; Pedersen, Søren; Osterballe, Ole; Veggerby, Chris; Poulsen, Lars K.

    2003-01-01

    House dust mite (HDM) allergy is a frequent cause of allergic asthma in children. Reduction of exposure seems to be the most logical way to treat these patients.......House dust mite (HDM) allergy is a frequent cause of allergic asthma in children. Reduction of exposure seems to be the most logical way to treat these patients....

  16. Modeling responses to respiratory house dust mite exposure.

    Science.gov (United States)

    Cates, Elizabeth C; Fattouh, Ramzi; Johnson, Jill R; Llop-Guevara, Alba; Jordana, Manel

    2007-01-01

    House dust mite (HDM) is the most pervasive indoor aeroallergen source worldwide. Allergens derived from HDM are associated with sensitization and allergic asthma. Allergic asthma is an immunologically driven disease characterized by a Th2-polarized immune response, eosinophilic inflammation, airway hyperreactivity, and remodeling. Animal models of asthma utilizing ovalbumin (OVA) exposure have afforded us considerable insight with respect to the mediators and cell types involved in allergic airway inflammation. However, OVA preparations and HDM are two vastly different materials. This chapter is specifically concerned with modeling responses to HDM exposure in mice. These studies have furnished new information and unlocked new lines of inquiry regarding biological responses to common aeroallergens. The complexity of HDM as an allergen source, with its plethora of protein and nonprotein immunogenic components, may influence the mechanisms underlying sensitization, inflammation and remodeling. Here, we will discuss this issue, along with giving critical thought to the use of experimental models. PMID:17684332

  17. Dust-bathing behavior of laying hens in enriched colony housing systems and an aviary system.

    Science.gov (United States)

    Louton, H; Bergmann, S; Reese, S; Erhard, M H; Rauch, E

    2016-07-01

    The dust-bathing behavior of Lohmann Selected Leghorn hens was compared in 4 enriched colony housing systems and in an aviary system. The enriched colony housing systems differed especially in the alignment and division of the functional areas dust bath, nest, and perches. Forty-eight-hour video recordings were performed at 3 time-points during the laying period, and focal animal sampling and behavior sampling methods were used to analyze the dust-bathing behavior. Focal animal data included the relative fractions of dust-bathing hens overall, of hens bathing in the dust-bath area, and of those bathing on the wire floor throughout the day. Behavior data included the number of dust-bathing bouts within a predefined time range, the duration of 1 bout, the number of and reasons for interruptions, and the number of and reasons for the termination of dust-bathing bouts. Results showed that the average duration of dust bathing varied between the 4 enriched colony housing systems compared with the aviary system. The duration of dust-bathing bouts was shorter than reported under natural conditions. A positive correlation between dust-bathing activity and size of the dust-bath area was observed. Frequently, dust baths were interrupted and terminated by disturbing influences such as pecking by other hens. This was especially observed in the enriched colony housing systems. In none of the observed systems, neither in the enriched colony housing nor in the aviary system, were all of the observed dust baths terminated "normally." Dust bathing behavior on the wire mesh rather than in the provided dust-bath area generally was observed at different frequencies in all enriched colony housing systems during all observation periods, but never in the aviary system. The size and design of the dust-bath area influenced the prevalence of dust-bathing behavior in that small and subdivided dust-bath areas reduced the number of dust-bathing bouts but increased the incidence of sham dust

  18. THE USE OF SUPEROXIDE DISMUTASE IN ACCELERATING SYMPTOM RELIEF IN ASTHMATIC AND HOUSE DUST MITE ALLERGIC CHILDREN RECEIVING HOUSE DUST MITE IMMUNOTHERAPY: DOUBLE BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL

    Directory of Open Access Journals (Sweden)

    Anang Endaryanto

    2015-09-01

    Full Text Available Objective: To evaluate the efficacy of superoxide dismutase (SOD in lung function (FEV1 reversibility and respiratory symptoms (drug scores, symptoms scores in asthmatic and house dust mite allergic children receiving house dust mites immunotherapy. Methods: Forty subjects aged 6–17 years old with asthma, tested positive for house dust mite allergy on skin prick test, and received immunotherapy were enrolled in this study. All subjects completed clinical based assessments and diary-based assessments for drug and symptom scores. Following a four-week baseline assessment, all subjects were randomized to receive SOD or placebo. Respiratory symptoms (drug and symptoms score and FEV1 were evaluated at the end of the 1st, 2nd, 3rd, and 4th weeks after randomization. Drug score, symptoms score, and FEV1 reversibility test results were analyzed using a Paired t test and repeated measure of ANOVA. Results: There was a significant difference in drug scores, symptoms score, and FEV1 reversibility test outcomes between SOD and placebo. SOD group showed a significant decrease in all outcome measures compared to those in placebo group. Conclusions: The use of SOD as antioxidants is effective in accelerating symptom relief for children with asthma and house dust mite allergy receiving house dust mite immunotherapy.

  19. Is House-Dust Nicotine a Good Surrogate for Household Smoking?

    OpenAIRE

    WHITEHEAD, TODD; Metayer, Catherine; Ward, Mary H; Nishioka, Marcia G.; Gunier, Robert; Colt, Joanne S.; Reynolds, Peggy; Selvin, Steve; Buffler, Patricia; Rappaport, Stephen M.

    2009-01-01

    The literature is inconsistent regarding associations between parental smoking and childhood leukemia, possibly because previous studies used self-reported smoking habits as surrogates for children's true exposures to cigarette smoke. Here, the authors investigated the use of nicotine concentrations in house dust as measures of children's exposure to cigarette smoke in 469 households from the Northern California Childhood Leukemia Study (1999–2007). House dust was collected by using high-volu...

  20. Concentration and determinants of molds and allergens in indoor air and house dust of French dwellings.

    Science.gov (United States)

    Dallongeville, Arnaud; Le Cann, Pierre; Zmirou-Navier, Denis; Chevrier, Cécile; Costet, Nathalie; Annesi-Maesano, Isabella; Blanchard, Olivier

    2015-12-01

    Molds and allergens are common indoor biocontaminants. The aims of this study were to assess the concentrations of common molds in indoor air and floor dust and the concentrations of house dust mite, cat and dog allergens in mattress dust in French dwellings, and to assess predictors of these concentrations. A sample of 150 houses in Brittany (western France) was investigated. Airborne Cladosporium and Penicillium were detected in more than 90% of the dwellings, Aspergillus in 46% and Alternaria in only 6% of the housings. Regarding floor dust samples, Cladosporium and Penicillium were detected in 92 and 80% of the housings respectively, Aspergillus in 49% and Alternaria in 14%. House dust mite allergens Der p1 and Der f1 were detected in 90% and 77% of the mattress dust samples respectively and Can f1 and Fel d1 in 37% and 89% of the homes. Airborne and dustborne mold concentrations, although not statistically correlated (except for Aspergillus) shared most of their predictors. Multivariate linear models for mold levels, explaining up to 62% of the variability, showed an influence of the season, of the age of the dwelling, of aeration habits, presence of pets, smoking, signals of dampness, temperature and relative humidity. Allergens in the dust of the mattress were strongly related to the presence of pets and cleaning practices of bedsheets, these factors accounting for 60% of the variability. This study highlights ubiquitous contamination by molds and underlines complex interaction between outdoor and indoor sources and factors. PMID:26094801

  1. Occurrence of Respiratory Symptoms Resulting from Exposure to House Dust Mites in Early Childhood

    Science.gov (United States)

    Jedrychowski, Wieslaw; Maugeri, Umberto; Zembala, Marek; Hajto, Barbara; Flak, Elzbieta; Mroz, Elzbieta; Jacek, Ryszard; Sowa, Agata; Perera, Frederica P.

    2009-01-01

    The aim of the study was to describe the distribution of house dust mite (HDM) allergens within homes of three-year-old children, to identify factors responsible for its variation and to test the hypothesis whether the content of HDM allergens exceeding 2 [mu]g/g dust may be regarded as a risk level of sensitization possibly affecting respiratory…

  2. House-dust mites in our homes are a contamination from outdoor sources

    DEFF Research Database (Denmark)

    Hallas, Thorkil E.

    2010-01-01

    Avoidance advices for house-dust mite sensitized persons are currently based upon the idea, that the mites (Dermatophagoides spp.) are part of the indoor fauna. A closer look at development stages in the house-dust samples shows, however, that only the mites' active stages are present there and...... in accordance with known physical laws. The occasional finding of higher concentrations is the result of synchronized populations of the mites developing outdoors and being passively transported into our homes by wind and dust. The hypothesis explains why we find mites in our homes but nonetheless...

  3. Dioxin-related compounds in house dust from New York State: Occurrence, in vitro toxic evaluation and implications for indoor exposure

    International Nuclear Information System (INIS)

    This study analysed sulphuric-acid-treated extracts of house dust from New York State with DR-CALUX assay and HRGC-HRMS to elucidate the total dioxin-like (DL) activities, the occurrence of various dioxin-related compounds (DRCs), including PBDD/Fs, and their toxic contribution. The DL activities were 30–8000, median 210 pg CALUX-TEQ/g. PCDD/Fs, PBDD/Fs and DL-PCBs were detected with a large variation in concentrations (0.12–80, 0.33–150, 0.46–35, medians 1.7, 2.1 and 5.6 ng/g, respectively) and profiles, indicating the existence of multiple contamination sources in homes. PCDD/Fs, PBDD/Fs and DL-PCBs with known potency theoretically contributed <1%–130%, <1%–21% and <1%–6.8%, respectively, of the measured CALUX-TEQs. These results and those from DR-CALUX assays with fractionated dust extracts indicated that a substantial portion of the CALUX-TEQs could be caused by unknown dust contaminants. Considering that the DRC intake from indoor dust ingestion can be significant, identification of unknown DL contaminants in indoor dust is necessary. -- Highlights: •First investigation of dioxin-like (DL) activities and PBDFs in American house dust. •Large variations in the CALUX-TEQ levels and DRC concentrations in dust. •Significant contribution of PBDFs to the total WHO-TEQ levels in dust. •Unknown contaminants may contribute considerably to the DL activities in dust. •Dust ingestion may increase the risk of dioxin-related adverse effects for children. -- PBDFs—degradation products of PBDEs—and unknown contaminants contributed significantly to the dioxin-like activities in New York house dust

  4. Non-PBDE halogenated flame retardants in Canadian indoor house dust: sampling, analysis, and occurrence.

    Science.gov (United States)

    Fan, Xinghua; Kubwabo, Cariton; Rasmussen, Pat E; Wu, Fang

    2016-04-01

    An analytical method was developed for the measurement of 18 novel halogenated flame retardants in house dust. Sample preparation was based on ultrasound-assisted solvent extraction and clean up with solid phase extraction (SPE). Sample extracts were analyzed by gas chromatography-mass spectrometry (GC/MS) operated in electron capture negative ion (ECNI) chemical ionization mode. Baseline data from 351 fresh (active) dust samples collected under the Canadian House Dust Study (CHDS) revealed that five out of 18 target chemicals were present with detection frequencies higher than 90 %. Median (range) concentrations for these five compounds were as follows: 104 (detection limits (MDLs). In addition, the method was also applied to the analysis of the targeted compounds in National Institute of Standards and Technology (NIST) standard reference material (SRM 2585, organic contaminants in house dust). Results from the current study could contribute to the potential certification of target chemicals in SRM 2585. PMID:26780041

  5. Immunoinformatics and Similarity Analysis of House Dust Mite Tropomyosin

    Directory of Open Access Journals (Sweden)

    Mohammad Mehdi Ranjbar

    2015-10-01

    Full Text Available Background: Dermatophagoides farinae and Dermatophagoides pteronyssinus are house dust mites (HDM that they cause severe asthma and allergic symptoms. Tropomyosin protein plays an important role in mentioned immune and allergic reactions to HDMs. Here, tropomyosin protein from Dermatophagoides spp. was comprehensively screened in silico for its allergenicity, antigenicity and similarity/conservation.Materials and Methods: The amino acid sequences of D. farinae tropomyosin, D. pteronyssinus and other mites were retrieved. We included alignments and evaluated conserved/ variable regions along sequences, constructed their phylogenetic tree and estimated overall mean distances. Then, followed by with prediction of linear B-cell epitope based on different approaches, and besides in-silico evaluation of IgE epitopes allergenicity (by SVMc, IgE epitope, ARPs BLAST, MAST and hybrid method. Finally, comparative analysis of results by different approaches was made.Results: Alignment results revealed near complete identity between D. farina and D. pteronyssinus members, and also there was close similarity among Dermatophagoides spp. Most of the variations among mites' tropomyosin were approximately located at amino acids 23 to 80, 108 to 120, 142 to 153 and 220 to 230. Topology of tree showed close relationships among mites in tropomyosin protein sequence, although their sequences in D. farina, D. pteronyssinus and Psoroptes ovis are more similar to each other and clustered. Dermanyssus gallinae (AC: Q2WBI0 has less relationship to other mites, being located in a separate branch. Hydrophilicity and flexibility plots revealed that many parts of this protein have potential to be hydrophilic and flexible. Surface accessibility represented 7 different epitopes. Beta-turns in this protein are with high probability in the middle part and its two terminals. Kolaskar and Tongaonkar method analysis represented 11 immunogenic epitopes between amino acids 7-16. From

  6. Evolution of the American Zero Energy House

    Directory of Open Access Journals (Sweden)

    Stanley Russell

    2011-05-01

    Full Text Available Interest in reducing energy use in buildings began in the U.S. in the 1930 with work at the Massachusetts Institute of Technology on solar heated structures. With the energy crises in the 1970s, efforts were made to reduce energy use in U.S. homes. Passive solar design involved insulated south oriented glazing systems, Trombe walls, sunspaces, flat plate collectors; thermal mass and optimally designed overhangs. It was discovered that by reducing building cooling and heating needs through energy conservation while implementing passive solar strategies the lowest energy use at a lower incremental cost could be achieved. Super-insulated homes were successful at minimizing heat loss and gain and the subsequent load on mechanical systems, but interest subsided as energy prices dropped in the 1980s. The passive solar homes and super-insulation movements, addressed passive heating and cooling, but other home energy end uses were not addressed. Throughout the late 1980s, the cost of solid state solar electricity production with photovoltaic cells declined and become affordable for individual house distributed generation. This paper is a survey of the evolution of the Zero Energy House in the U.S. and the related technologies from its experimental beginnings to its realization in several recent projects.

  7. Measuring airborne microorganisms and dust from livestock houses

    OpenAIRE

    Yang Zhao, Yang

    2011-01-01

      Airborne transmission has been suspected to be responsible for epidemics of highly infectious disease in livestock production. In such transmission, the pathogenic microorganisms may associate with dust particles. However, the extent to which airborne transmission plays a role in the spread of diseases between farms, and the relationship between microorganisms and dust remain unclear. In order to better understand airborne transmission and to set up effective control techniques, this s...

  8. Molecular mechanisms of dust-induced toxicity in human corneal epithelial cells: Water and organic extract of office and house dust.

    Science.gov (United States)

    Xiang, Ping; Liu, Rong-Yan; Sun, Hong-Jie; Han, Yong-He; He, Rui-Wen; Cui, Xin-Yi; Ma, Lena Q

    2016-01-01

    Human corneal epithelial (HCE) cells are continually exposed to dust in the air, which may cause corneal epithelium damage. Both water and organic soluble contaminants in dust may contribute to cytotoxicity in HCE cells, however, the associated toxicity mechanisms are not fully elucidated. In this study, indoor dust from residential houses and commercial offices in Nanjing, China was collected and the effects of organic and water soluble fraction of dust on primary HCE cells were examined. The concentrations of heavy metals in the dust and dust extracts were determined by ICP-MS and PAHs by GC-MS, with office dust having greater concentrations of heavy metals and PAHs than house dust. Based on LC50, organic extract was more toxic than water extract, and office dust was more toxic than house dust. Accordingly, the organic extracts induced more ROS, malondialdehyde, and 8-Hydroxydeoxyguanosine and higher expression of inflammatory mediators (IL-1β, IL-6, and IL-8), and AhR inducible genes (CYP1A1, and CYP1B1) than water extracts (pdust presented greater suppression of superoxide dismutase and catalase activity than those of house dust. In addition, exposure to dust extracts activated NF-κB signal pathway except water extract of house dust. The results suggested that both water and organic soluble fractions of dust caused cytotoxicity, oxidative damage, inflammatory response, and activation of AhR inducible genes, with organic extracts having higher potential to induce adverse effects on primary HCE cells. The results based on primary HCE cells demonstrated the importance of reducing contaminants in indoor dust to reduce their adverse impacts on human eyes. PMID:27131017

  9. IgE cross-reactivity between house dust mite allergens and Ascaris lumbricoides antigens

    OpenAIRE

    Valmonte, Gardette R.; Cauyan, Gil A.; Ramos, John Donnie A.

    2012-01-01

    Background Common antigens between intestinal parasites and environmental allergens may play a role in the modulation of allergic immune responses. There is a growing interest in investigating cross-reactivity between common helminths and dust mites affecting humans, particularly in the tropics. Objective This study examined the cross-reactivity between the human roundworm Ascaris lumbricoides (Al) and three house dust mite (HDM) species. Methods Specific serum IgE levels to HDM species Blomi...

  10. Child car seats – a habitat for house dust mites and reservoir for harmful allergens

    Directory of Open Access Journals (Sweden)

    David Clarke

    2015-02-01

    Full Text Available [b]Introduction and objective[/b]. House dust mites produce allergens which can cause or aggravate diseases such as asthma, eczema and rhinitis. The objectives of this study are to quantify typical house dust mite and Der p 1 allergen levels in child car seats, and to determine external variables that may influence mite populations in cars. [b]Materials and Methods[/b]. Dust samples were collected from the child car seats and driver seats of 106 cars using a portable vacuum sampling pump over a two minute sampling period. Mites were counted and identified and results were expressed as mites per gram (mites/g of dust, while Der p 1 content of samples were measured by enzyme-linked immunosorbent assay (ELISA. Questionnaires were completed by participants to identify environmental and behavioural effects on mite populations. Results were analysed using General Linear Model (GLM procedures. [b]Results[/b]. Twelve species of mites, of which nine are known to produce harmful allergens, were recorded from 212 dust samples. Over 80% of drivers’ seats and over 77% of child car seats harboured dust mites with a significant correlation (p = 0.001 between the mites/g of dust and Der p 1 content recovered from each seat. A mean of 53 mites/g of dust per seat was recovered, with a mean Der p 1 level of 1.1µg/g. Over 12% of driver seats and 15% of child car seats contained house dust mite levels sufficient to be risk factors for sensitisation and allergic reactions. [b]Conclusions[/b]. Child car seats and driver seats are habitats to a range of mite species which can be present in sufficient concentrations to cause or aggravate allergen related illnesses in individuals who are genetically predisposed.

  11. Investigating a novel flame retardant known as V6: measurements in baby products, house dust, and car dust.

    Science.gov (United States)

    Fang, Mingliang; Webster, Thomas F; Gooden, David; Cooper, Ellen M; McClean, Michael D; Carignan, Courtney; Makey, Colleen; Stapleton, Heather M

    2013-05-01

    With the phase-out of polybrominated diphenyl ether (PBDE) flame retardants, the use of new and alternate flame retardants has been increasing. 2,2-bis(chloromethyl)propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate, known as V6, is a flame retardant applied to polyurethane foam commonly found in furniture and automobile foam. However, to the authors' knowledge, no research has been conducted on V6 levels in the environment. The intention of this study was to measure the concentration of V6 in foam collected from baby products where it was recently detected and measure levels in dust samples collected from homes and automobiles in the Boston, MA area. To accomplish this, a pure V6 commercial standard was purchased from a Chinese manufacturer and purified (>98%). An analytical method to measure V6 in dust samples using liquid chromatography tandem mass spectrometry (LC/MS-MS) was developed. Extraction was conducted using accelerated solvent extraction (ASE) and extracts were purified using an ENVI-Florisil SPE column (500 mg, 3 mL). V6 was measured in foam samples collected from baby products with a concentration ranging from 24,500,000 to 59,500,000 ng/g of foam (n = 12, average ± sd: 46,500,000 ± 12,000,000 ng/g; i.e., on average, 4.6% of the foam mass was V6). V6 was also detected in 19 of 20 car dust samples and 14 of 20 house dust samples analyzed. The concentration of V6 in the house dust ranged from samples analyzed. A significant correlation was also observed between V6 and TCEP in the dust samples suggesting that the use of V6 is a significant source of TCEP in the indoor environment. PMID:23565680

  12. Elemental composition of airborne dust in the shale shaker house during an offshore drilling operation

    DEFF Research Database (Denmark)

    Hansen, A.B.; Larsen, E.; Hansen, L.V.; Lyngsaae, M.; Kunze, H.

    1991-01-01

    During 2 days of an offshore drilling operation in the North Sea, 16 airborne dust samples from the atmosphere of the Shale Shaker House were collected onto filters. During this operation, drilling mud composed of a water slurry of barite (BaSO4) together with minor amounts of additives, among th...... coupled plasma-mass spectrometry). The total amount of dust collected varied from 0.04 to 1.41 mg m-3 with barium (Ba) as the single most abundant element. The open shale shakers turned out to be the major cause of generation of dust from the solid components of the drilling mud....

  13. Dermatophytes, related keratinophilic and opportunistic fungi in indoor dust of houses and hospitals

    OpenAIRE

    Singh I; Mishra A; Kushwaha RKS

    2009-01-01

    Dermatophytes, related keratinophilic and opportunistic fungi were isolated from indoor dust samples of 46 hospitals and 47 houses in Kanpur. A total of 19 fungi represented by 11 genera were isolated by the hair-baiting technique from 230 and 235 samples from hospitals and houses respectively. The isolated fungi are Acremonium implicatum (Indian Type Culture Collection) ITCC 5266 , A. strictum (Germplasm Centre for Keratinophilic Fungi) GPCK 1137 , Aphanoascus fulvescens GPCK 1081 , ...

  14. EXPOSURE TO SWINE HOUSING DUST MODULATES MACROPHAGE MORPHOLOGY AND FUNCTION

    Directory of Open Access Journals (Sweden)

    Ruth J. Pender

    2014-01-01

    Full Text Available Swine Confinement Facility (SCF dust consists of a complex mixture of feed grain particles, bacterial components, organic particulates and gases. When these particles are inhaled they deposit along the respiratory tract and mediate respiratory symptoms and disease in swine farmers and facility workers. Macrophages ingest and eliminate microbes and debris under chronic conditions; however, the role of macrophages in agricultural-related respiratory disease has not been fully elucidated. The goal was to evaluate the hypothesis that chronic exposure to SCF dust causes inflammation by modulating pulmonary protein levels and macrophage function. Balb/c mice were exposed to 5, 12.5 and 25% SCF Dust Extract (DE via nebulization 30 min/day five days a week, for eight weeks with weekends excluded. Bronchoalveolar Lavage Fluid (BALF was collected and analyzed for protein concentration, leukocyte distribution and macrophage morphology. For comparison, THP-1 monocytic cells were exposed to 0.1-10% DE overnight and evaluated for phagocytosis and reactive oxygen species production. Repeated exposure to DE via nebulizer caused a significant increase in protein concentration and inflammatory cell number, namely macrophages, in a dose-dependent manner within the lung as compared to controls. Macrophages with pseudopods and vacuoles were the most abundant leukocytes within BALF of mice exposed to DE. Similarly, in vitro studies with 10% DE treated THP-1 cells revealed enhanced phagocytosis (p<0.05, pseudopodia and vacuolization following exposure to compared to control cells. In addition, there were time- and dose-dependent increases of intracellular ROS production by THP-1 cells exposed to 5 and 10% DE compared to control (p<0.01. These findings indicate repeated, long-term inhalation of swine confinement facility dust may mediate chronic airway and lung inflammation through modulation of protein concentration and macrophage function. The aerosolized dust

  15. Phthalates in dormitory and house dust of northern Chinese cities: Occurrence, human exposure, and risk assessment.

    Science.gov (United States)

    Li, Hai-Ling; Song, Wei-Wei; Zhang, Zi-Feng; Ma, Wan-Li; Gao, Chong-Jing; Li, Jia; Huo, Chun-Yan; Mohammed, Mohammed O A; Liu, Li-Yan; Kannan, Kurunthachalam; Li, Yi-Fan

    2016-09-15

    Phthalates are widely used chemicals in household products, which severely affect human health. However, there were limited studies emphasized on young adults' exposure to phthalates in dormitories. In this study, seven phthalates were extracted from indoor dust that collected in university dormitories in Harbin, Shenyang, and Baoding, in the north of China. Dust samples were also collected in houses in Harbin for comparison. The total concentrations of phthalates in dormitory dust in Harbin and Shenyang samples were significantly higher than those in Baoding samples. The total geometric mean concentration of phthalates in dormitory dust in Harbin was lower than in house dust. Di-(2-ethylhexyl) phthalate (DEHP) was the most abundant phthalate in both dormitory and house dust. The daily intakes of the total phthalates, carcinogenic risk (CR) of DEHP, hazard index (HI) of di-isobutyl phthalate (DiBP), dibutyl phthalate (DBP), and DEHP were estimated, the median values for all students in dormitories were lower than adults who live in the houses. Monte Carlo simulation was applied to predict the human exposure risk of phthalates. HI of DiBP, DBP, and DEHP was predicted according to the reference doses (RfD) provided by the United States Environmental Protection Agency (U.S.EPA) and the reference doses for anti-androgenicity (RfD AA) developed by Kortenkamp and Faust. The results indicated that the risks of some students had exceeded the limitation, however, the measured results were not exceeded the limitation. Risk quotients (RQ) of DEHP were predicted based on China specific No Significant Risk Level (NSRL) and Maximum Allowable Dose Level (MADL). The predicted results of CR and RQ of DEHP suggested that DEHP could pose a health risk through intake of indoor dust. PMID:27186877

  16. Associations between brominated flame retardants in house dust and hormone levels in men

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Paula I. [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Stapleton, Heather M. [Nicholas School of the Environment, Box 90328, Duke University, Durham, NC 27708 (United States); Mukherjee, Bhramar [Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109 (United States); Hauser, Russ [Department of Environmental Health, Harvard School of Public Health, 677 Huntington Ave., Boston, MA 02115 (United States); Meeker, John D., E-mail: meekerj@umich.edu [Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109 (United States)

    2013-02-15

    Brominated flame retardants (BFRs) are used in the manufacture of a variety of materials and consumer products in order to meet fire safety standards. BFRs may persist in the environment and have been detected in wildlife, humans and indoor dust and air. Some BFRs have demonstrated endocrine and reproductive effects in animals, but human studies are limited. In this exploratory study, we measured serum hormone levels and flame retardant concentrations [31 polybrominated diphenyl ether (PBDE) congeners and 6 alternate flame retardants] in house dust from men recruited through a US infertility clinic. PBDE congeners in dust were grouped by commercial mixtures (i.e. penta-, octa- and deca-BDE). In multivariable linear regression models adjusted by age and body mass index (BMI), significant positive associations were found between house dust concentrations of pentaBDEs and serum levels of free T4, total T3, estradiol, and sex hormone binding globulin (SHBG), along with an inverse association with follicle stimulating hormone (FSH). There were also positive associations of octaBDE concentrations with serum free T4, thyroid stimulating hormone (TSH), luteinizing hormone (LH) and testosterone and an inverse association of decaBDE concentrations with testosterone. Hexabromocyclododecane (HBCD) was associated with decreased SHBG and increased free androgen index. Dust concentrations of bis-tribromophenoxyethane (BTBPE) and tetrabromo-diethylhexylphthalate (TBPH) were positively associated with total T3. These findings are consistent with our previous report of associations between PBDEs (BDE 47, 99 and 100) in house dust and hormone levels in men, and further suggest that exposure to contaminants in indoor dust may be leading to endocrine disruption in men. - Highlights: ► Brominated flame retardants (BFRs) including PBDEs and alternates were measured. ► Exposure to BFRs is characterized from concentrations in participant vacuum bag dust. ► Exposure to PBDEs and

  17. Associations between brominated flame retardants in house dust and hormone levels in men

    International Nuclear Information System (INIS)

    Brominated flame retardants (BFRs) are used in the manufacture of a variety of materials and consumer products in order to meet fire safety standards. BFRs may persist in the environment and have been detected in wildlife, humans and indoor dust and air. Some BFRs have demonstrated endocrine and reproductive effects in animals, but human studies are limited. In this exploratory study, we measured serum hormone levels and flame retardant concentrations [31 polybrominated diphenyl ether (PBDE) congeners and 6 alternate flame retardants] in house dust from men recruited through a US infertility clinic. PBDE congeners in dust were grouped by commercial mixtures (i.e. penta-, octa- and deca-BDE). In multivariable linear regression models adjusted by age and body mass index (BMI), significant positive associations were found between house dust concentrations of pentaBDEs and serum levels of free T4, total T3, estradiol, and sex hormone binding globulin (SHBG), along with an inverse association with follicle stimulating hormone (FSH). There were also positive associations of octaBDE concentrations with serum free T4, thyroid stimulating hormone (TSH), luteinizing hormone (LH) and testosterone and an inverse association of decaBDE concentrations with testosterone. Hexabromocyclododecane (HBCD) was associated with decreased SHBG and increased free androgen index. Dust concentrations of bis-tribromophenoxyethane (BTBPE) and tetrabromo-diethylhexylphthalate (TBPH) were positively associated with total T3. These findings are consistent with our previous report of associations between PBDEs (BDE 47, 99 and 100) in house dust and hormone levels in men, and further suggest that exposure to contaminants in indoor dust may be leading to endocrine disruption in men. - Highlights: ► Brominated flame retardants (BFRs) including PBDEs and alternates were measured. ► Exposure to BFRs is characterized from concentrations in participant vacuum bag dust. ► Exposure to PBDEs and

  18. Determinants of manganese levels in house dust samples from the CHAMACOS cohort

    Energy Technology Data Exchange (ETDEWEB)

    Gunier, R.B., E-mail: gunier@berkeley.edu [Center for Environmental Research and Children’s Health (CERCH), School of Public Health, University of California, Berkeley, CA (United States); Jerrett, M. [Center for Environmental Research and Children’s Health (CERCH), School of Public Health, University of California, Berkeley, CA (United States); Smith, D.R.; Jursa, T. [Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA (United States); Yousefi, P.; Camacho, J.; Hubbard, A.; Eskenazi, B.; Bradman, A. [Center for Environmental Research and Children’s Health (CERCH), School of Public Health, University of California, Berkeley, CA (United States)

    2014-11-01

    Introduction: Manganese (Mn) is an essential nutrient, but at high exposure levels Mn is a neurotoxicant. The fungicides maneb and mancozeb are approximately 21% Mn by weight and more than 150,000 kg are applied each year to crops in the Salinas Valley, California. It is not clear, however, whether agricultural use of these fungicides increases Mn levels in homes. Materials and methods: We collected house dust samples from 378 residences enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study with a second sample collected approximately nine months later from 90 of the residences. House dust samples were analyzed for Mn using inductively coupled plasma optical emission spectroscopy. Information from interviews, home inspections, and pesticide use reports was used to identify potential predictors of Mn dust concentrations and loadings. Results: Mn was detectable in all dust samples. The median Mn concentration was 171 μg/g and median Mn loading was 1,910 μg/m{sup 2} at first visit. In multivariable models, Mn dust concentrations and loadings increased with the number of farmworkers in the home and the amount of agricultural Mn fungicides applied within three kilometers of the residence during the month prior to dust sample collection. Dust concentrations of Mn and other metals (lead, cadmium and chromium) were higher in residences located in the southern Salinas Valley compared those located in other areas of the Salinas Valley. Dust loadings of Mn and other metals were also higher in residences located on Antioch Loam soil than other soil types, and in homes with poor or average housekeeping practices. Conclusions: Agricultural use of Mn containing fungicides was associated with Mn dust concentrations and loadings in nearby residences and farmworker homes. Housekeeping practices and soil type at residence were also important factors related to dust metal concentrations and loadings. - Highlights: • Manganese dust

  19. Determinants of manganese levels in house dust samples from the CHAMACOS cohort

    International Nuclear Information System (INIS)

    Introduction: Manganese (Mn) is an essential nutrient, but at high exposure levels Mn is a neurotoxicant. The fungicides maneb and mancozeb are approximately 21% Mn by weight and more than 150,000 kg are applied each year to crops in the Salinas Valley, California. It is not clear, however, whether agricultural use of these fungicides increases Mn levels in homes. Materials and methods: We collected house dust samples from 378 residences enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study with a second sample collected approximately nine months later from 90 of the residences. House dust samples were analyzed for Mn using inductively coupled plasma optical emission spectroscopy. Information from interviews, home inspections, and pesticide use reports was used to identify potential predictors of Mn dust concentrations and loadings. Results: Mn was detectable in all dust samples. The median Mn concentration was 171 μg/g and median Mn loading was 1,910 μg/m2 at first visit. In multivariable models, Mn dust concentrations and loadings increased with the number of farmworkers in the home and the amount of agricultural Mn fungicides applied within three kilometers of the residence during the month prior to dust sample collection. Dust concentrations of Mn and other metals (lead, cadmium and chromium) were higher in residences located in the southern Salinas Valley compared those located in other areas of the Salinas Valley. Dust loadings of Mn and other metals were also higher in residences located on Antioch Loam soil than other soil types, and in homes with poor or average housekeeping practices. Conclusions: Agricultural use of Mn containing fungicides was associated with Mn dust concentrations and loadings in nearby residences and farmworker homes. Housekeeping practices and soil type at residence were also important factors related to dust metal concentrations and loadings. - Highlights: • Manganese dust

  20. Elemental composition of airborne dust in the shale shaker house during an offshore drilling operation

    DEFF Research Database (Denmark)

    Hansen, A.B.; Larsen, E.; Hansen, L.V.;

    1991-01-01

    chrome lignosulphonate and chrome lignite, was circulated between the borehole and the Shale Shaker House. The concentration of airborne dust in the atmosphere was determined and the elemental composition of the particles analysed by both PIXE (proton-induced X-ray emission) and ICP-MS (inductively...

  1. A controlled intervention study concerning the effect of intended temperature rise on house dust mite load

    DEFF Research Database (Denmark)

    Sidenius, Kirsten E; Hallas, Thorkil E; Poulsen, Lars K.; Mosbech, Holger

    2002-01-01

    In epidemiological studies, increased indoor temperature--producing a lower relative humidity--is associated with low house dust mite (HDM) load. Twenty-eight dwellings were allocated for either intervention (12/15 completed) or control (11/13 completed). In the intervention group, participants w...

  2. Effect of mattress and pillow encasings on children with asthma and house dust mite allergy

    DEFF Research Database (Denmark)

    Halken, Susanne; Høst, Arne; Niklassen, Ulla;

    2003-01-01

    BACKGROUND: House dust mite (HDM) allergy is a frequent cause of allergic asthma in children. Reduction of exposure seems to be the most logical way to treat these patients. OBJECTIVE: Our aim was to investigate whether mattress and pillow encasings resulted in an effective long-term control of H...

  3. Beta(1-->3)-glucan in house dust of German homes: housing characteristics, occupant behavior, and relations with endotoxins, allergens, and molds.

    OpenAIRE

    Gehring, U; Douwes, J; Doekes, G.; Koch, A.; Bischof, W; B. Fahlbusch; Richter, K.; Wichmann, H. E.; Heinrich, J.; ,

    2001-01-01

    beta(1-->3)-Glucans are potent proinflammatory agents that have been suggested to play a role in indoor-related respiratory health effects. The aim of this study was to assess whether beta(1-->3)-glucan concentrations in house dust are correlated with levels of endotoxins, allergens, and culturable mold spore counts in house dust. Further, the associations of beta(1-->3)-glucan with housing characteristics and occupant behavior were assessed. beta(1-->3)-Glucan was measured in settled house d...

  4. Monitoring and reducing exposure of infants to pollutants in house dust.

    Science.gov (United States)

    Roberts, John W; Wallace, Lance A; Camann, David E; Dickey, Philip; Gilbert, Steven G; Lewis, Robert G; Takaro, Tim K

    2009-01-01

    The health risks to babies from pollutants in house dust may be 100 times greater than for adults. The young ingest more dust and are up to ten times more vulnerable to such exposures. House dust is the main exposure source for infants to allergens, lead, and PBDEs, as well as a major source of exposure to pesticides, PAHs, Gram-negative bacteria, arsenic, cadmium, chromium, phthalates, phenols, and other EDCs, mutagens, and carcinogens. Median or upper percentile concentrations in house dust of lead and several pesticides and PAHs may exceed health-based standards in North America. Early contact with pollutants among the very young is associated with higher rates of chronic illness such as asthma, loss of intelligence, ADHD, and cancer in children and adults. The potential of infants, who live in areas with soil contaminated by automotive and industrial emissions, can be given more protection by improved home cleaning and hand washing. Babies who live in houses built before 1978 have a prospective need for protection against lead exposures; homes built before 1940 have even higher lead exposure risks. The concentration of pollutants in house dust may be 2-32 times higher than that found in the soil near a house. Reducing infant exposures, at this critical time in their development, may reduce lifetime health costs, improve early learning, and increase adult productivity. Some interventions show a very rapid payback. Two large studies provide evidence that home visits to reduce the exposure of children with poorly controlled asthma triggers may return more than 100% on investment in 1 yr in reduced health costs. The tools provided to families during home visits, designed to reduce dust exposures, included vacuum cleaners with dirt finders and HEPA filtration, allergy control bedding covers, high-quality door mats, and HEPA air filters. Infants receive their highest exposure to pollutants in dust at home, where they spend the most time, and where the family has the

  5. 75 FR 19920 - Native American Housing Assistance and Self-Determination Reauthorization Act of 2008: Negotiated...

    Science.gov (United States)

    2010-04-16

    ... URBAN DEVELOPMENT 24 CFR Part 1000 Native American Housing Assistance and Self-Determination... Native American Housing Assistance and Self-Determination Reauthorization Act of 2008. The primary... CONTACT: Rodger J. Boyd, Deputy Assistant Secretary for Native American Programs, Office of Public...

  6. 75 FR 7559 - Native American Housing Assistance and Self-Determination Reauthorization Act of 2008: Negotiated...

    Science.gov (United States)

    2010-02-22

    ... Americans. NAHASDA eliminated several separate assistance programs and replaced them with a single block... URBAN DEVELOPMENT 24 CFR Part 1000 Native American Housing Assistance and Self-Determination... Native American Housing Assistance and Self-Determination Reauthorization Act of 2008. The...

  7. Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection: Genomic Insights

    KAUST Repository

    Al-Garawi, A.

    2011-12-14

    Respiratory viral infections have been associated with an increased incidence of allergic asthma. However, the mechanisms by which respiratory infections facilitate allergic airway disease are incompletely understood.We previously showed that exposure to a low dose of house dust mite (HDM) resulted in enhanced HDM-mediated allergic airway inflammation, and, importantly, marked airway hyperreactivity only when allergen exposure occurred during an acute influenza A infection. In this study, we evaluated the impact of concurrent influenza infection and allergen exposure at the genomic level, using whole-genome micro-array. Our data showed that, in contrast to exposure to a low dose of HDM, influenza A infection led to a dramatic increase in gene expression, particularly of TLRs, C-type lectin receptors, several complement components, as well as FcεR1. Additionally, we observed increased expression of a number of genes encoding chemokines and cytokines associated with the recruitment of proinflammatory cells. Moreover, HDM exposure in the context of an influenza A infection resulted in the induction of unique genes, including calgranulin A (S100a8), an endogenous damage-associated molecular pattern and TLR4 agonist. In addition, we observed significantly increased expression of serum amyloid A (Saa3) and serine protease inhibitor 3n (Serpina3n). This study showed that influenza infection markedly increased the expression of multiple gene classes capable of sensing allergens and amplifying the ensuing immune-inflammatory response. We propose that influenza A infection primes the lung environment in such a way as to lower the threshold of allergen responsiveness, thus facilitating the emergence of a clinically significant allergic phenotype. Copyright © 2012 by The American Association of Immunologists, Inc.

  8. Double blind trial of ionisers in children with asthma sensitive to the house dust mite.

    OpenAIRE

    Warner, J. A.; Marchant, J L; Warner, J O

    1993-01-01

    BACKGROUND--Manufacturers of ionisers claim many benefits from the use of their devices, including the relief of asthma. Particles removed from the air are likely to include airborne allergens, so ionisers may achieve an effect by reducing the allergen load. METHODS--The effect of ionisers on airborne concentrations of house dust mite allergen Der p I was investigated in a double blind, crossover, placebo controlled trial in the homes of 20 children with allergic asthma. Subjects recorded the...

  9. Inflammatory and Remodeling Events in Asthma with Chronic Exposure to House Dust Mites: A Murine Model

    OpenAIRE

    Ahn, Joong Hyun; Kim, Chi Hong; Kim, Yong Hyun; Kim, Seung Joon; Lee, Sook-Young; Kim, Young Kyoon; Kim, Kwan Hyoung; Moon, Hwa Sik; Song, Jeong Sup; Park, Sung Hak; Kwon, Soon Seog

    2007-01-01

    Although animal models with ovalbumin have been used to study chronic asthma, there are difficulties in inducing recurrence as well as in maintaining chronic inflammation in this system. Using a murine model of house dust mite (HDM)-induced bronchial asthma, we examined the airway remodeling process in response to the chronic exposure to HDM. During the seventh and twelfth weeks of study, HDM were inhaled through the nose for three consecutive days and airway responsiveness was measured. Twen...

  10. Sensitization to house-dust mite and mite fauna in selected children's homes in Kütahya, Turkey.

    Science.gov (United States)

    Akdemir, Cihangir; Yilmaz, Sema

    2009-01-01

    The aim of this study was to determine the relationship between the house-dust mite allergy and prevalence of house-dust mites in dwellings of children who were tested for specific IgE against Dermatophagoides pteronyssinus (D. pteronyssinus) and D. farinae on the suspicion of allergic rhinitis, dermatitis and asthma. All dust specimens collected from children's houses were investigated under a light microscope. House-dust mites were found in 31.7% of houses of children with a specific IgE, while the rate was 27.5% in houses of those without a specific IgE. Overall, house dust specimens collected from a total of 92 houses were examined, and mites were found in 27 (29.3%) of them. Both Der p and Der f were found in 38 (92.7%), while mixed allergy (D. pteronyssinus + D. farinae) was found in 3 (7.3%). Der p allergy (100%) was found in all of the allergic children, while no child was found with specific IgE for Der f allergy, except in mixed allergies. PMID:19817266

  11. Isolation and characterization of the 68 kD allergen from house dust mite Dermatophagoides pteronyssinus

    Directory of Open Access Journals (Sweden)

    KATARINA MILOVANOVIĆ

    2009-05-01

    Full Text Available House dust mites (HDM represent a major source of allergens, contributing to the increasing incidence of type I hypersensitivity disease worldwide. Over 30 different IgE-binding proteins from the HDM extract were detected. Although group 1 and 2 have been identified as major allergens, due to the safety and efficacy of allergy diagnosis and immunotherapy, there is a need to carefully evaluate the clinical relevance of other allergens present in the HDM extract. In regard to this, a high molecular mass allergen of about 68 kD was purified from the HDM extract using a combination of gel permeation chromatography and reversed-phase chromatography. The IgG and IgE reactivity of the purified protein were preserved during the purification process, as confirmed by Western blot analysis with polyclonal rabbit antibodies and dot blot analysis with a pool of sera from subjects with house dust mite allergy, respectively. In addition, the IgE reactivity was confirmed using ELISA testing with nine patient sera. The biological potency of the 68 kD allergen was confirmed by skin prick testing in five allergic subjects, suggesting that the high molecular mass allergen is a good candidate for component-resolved diagnosis of house dust mite allergy and eventual therapeutic treatment.

  12. House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection

    OpenAIRE

    Kei E Fujimura; Demoor, Tine; Rauch, Marcus; Faruqi, Ali A.; Jang, Sihyug; Johnson, Christine C.; Boushey, Homer A.; Zoratti, Edward; Ownby, Dennis; Lukacs, Nicholas W; Lynch, Susan V.

    2013-01-01

    Early-life exposure to dogs is protective against allergic disease development, and dog ownership is associated with a distinct milieu of house dust microbial exposures. Here, we show that mice exposed to dog-associated house dust are protected against airway allergen challenge. These animals exhibit reduced Th2 cytokine production, fewer activated T cells, and a distinct gut microbiome composition, highly enriched for Lactobacillus johnsonii, which itself can confer airway protection when or...

  13. Dermatophytes, related keratinophilic and opportunistic fungi in indoor dust of houses and hospitals

    Directory of Open Access Journals (Sweden)

    Singh I

    2009-01-01

    Full Text Available Dermatophytes, related keratinophilic and opportunistic fungi were isolated from indoor dust samples of 46 hospitals and 47 houses in Kanpur. A total of 19 fungi represented by 11 genera were isolated by the hair-baiting technique from 230 and 235 samples from hospitals and houses respectively. The isolated fungi are Acremonium implicatum (Indian Type Culture Collection ITCC 5266 , A. strictum (Germplasm Centre for Keratinophilic Fungi GPCK 1137 , Aphanoascus fulvescens GPCK 1081 , Arthroderma simii GPCK 1275 , Chrysosporium queenslandicum ITCC 5270 , C. indicum ITCC 5269 , C. pannicola GPCK 1022 , C. tropicum GPCK 1269 , Ctenomyces serratus ITCC 5267 , Gymnoascus reessii ITCC 5265 , Malbranchea fulva GPCK 1075 , Malbranchea pulchella ITCC 5268 , Micosporum gypseum GPCK 1038 , Microsporum cookei GPCK 2001, M. fulvum GPCK 2002 , Paecilomyces lilacinum GPCK 1080 , Penicillium expansum GPCK 1082, Trichophyton mentagrophytes GPCK 2003 and T. terrestre GPCK 2004. In hospitals, the minimum frequency was of Ctenomyces serratus ITCC 5267 while the maximum frequency was of Arthroderma simii GPCK 1275 . In houses, Chrysosporium queenslandicum ITCC 5270 and C. tropicum GPCK 1269 were with minimum and maximum frequencies respectively. This makes the first report of these fungi with keratinolytic ability in the indoor dust of hospitals and houses.

  14. 77 FR 71513 - Native American Housing Assistance and Self-Determination Reauthorization Act of 2008: Amendments...

    Science.gov (United States)

    2012-12-03

    ... Opportunities for Native Americans Act of 2004, (Pub. L. 108-393, approved October 30, 2004); Native American... simplified HUD's system of housing assistance to Native Americans by eliminating several separate HUD... funded programs for the benefit of Native Americans, and that HUD cannot dictate that this funding...

  15. SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms

    DEFF Research Database (Denmark)

    Mosbech, Holger; Canonica, G Walter; Backer, Vibeke; de Blay, Frederic; Klimek, Ludger; Broge, Louise; Ljørring, Christian

    2015-01-01

    analysis for the entire trial population showed no statistically significant difference between the placebo and actively treated groups. No safety concerns were observed. CONCLUSION: Efficacy in mild to severe AR of 6 SQ-HDM compared with placebo was demonstrated by statistically significant improvements......BACKGROUND: House dust mite (HDM) allergy is associated with persistent allergic rhinitis (AR) and allergic asthma. OBJECTIVE: To investigate the efficacy and safety of a SQ HDM sublingually administered immunotherapy tablet (ALK, Hørsholm, Denmark) in adults and adolescents with HDM respiratory...... subgroup, the absolute difference in end-of-treatment TCRS between 6 SQ-HDM and placebo was -0.78 (95% confidence interval -1.47 to -0.07, relative difference 28.8%, P = .0357). Furthermore, a significant difference was found for the total score of the Rhinitis Quality of Life Questionnaire with...

  16. The Fate of Saharan Dust Across the Atlantic and Implications for a Central American Dust Barrier

    Science.gov (United States)

    Nowottnick, E.; Colarco, P.; da Silva, A.; Hlavka, D.; McGill, M.

    2011-01-01

    Saharan dust was observed over the Caribbean basin during the summer 2007 NASA Tropical Composition, Cloud, and Climate Coupling (TC4) field experiment. Airborne Cloud Physics Lidar (CPL) and satellite observations from MODIS suggest a barrier to dust transport across Central America into the eastern Pacific. We use the NASA GEOS-5 atmospheric transport model with online aerosol tracers to perform simulations of the TC4 time period in order to understand the nature of this barrier. Our simulations are driven by the Modem Era Retrospective-Analysis for Research and Applications (MERRA) meteorological analyses. We evaluate our baseline simulated dust distributions using MODIS and CALIOP satellite and ground-based AERONET sun photometer observations. GEOS-5 reproduces the observed location, magnitude, and timing of major dust events, but our baseline simulation does not develop as strong a barrier to dust transport across Central America as observations suggest. Analysis of the dust transport dynamics and lost processes suggest that while both mechanisms play a role in defining the dust transport barrier, loss processes by wet removal of dust are about twice as important as transport. Sensitivity analyses with our model showed that the dust barrier would not exist without convective scavenging over the Caribbean. The best agreement between our model and the observations was obtained when dust wet removal was parameterized to be more aggressive, treating the dust as we do hydrophilic aerosols.

  17. Levels of phthalate esters in settled house dust from urban dwellings with young children in Nanjing, China

    Science.gov (United States)

    Zhang, Qi; Lu, Xiao-Mei; Zhang, Xiao-Ling; Sun, Yong-Gang; Zhu, Dong-Mei; Wang, Bing-Ling; Zhao, Ren-Zheng; Zhang, Zheng-Dong

    2013-04-01

    To investigate the levels and possible determinants of phthalate esters (PEs) in settled house dust from urban dwellings with young children, dust was collected from 215 urban houses in Nanjing, China, and 145 outdoor settled dust samples were collected nearby. Six PEs were measured by gas chromatography/mass spectrometry. All PEs were detected in the dust from approximately 90% of the houses, with the exception of dioctyl phthalate (DOP), which had only a 59% detection rate. Di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP) were the most abundant PEs, with geometric means of 110 and 16.4 μg g-1, respectively, and maximal concentrations 9950 and 2150 μg g-1. Factor analysis showed that DBP, DEHP and benzyl butyl phthalate (BBP) might come from the same source and were significantly influenced by the use of solid-wood floor wax. High BBP, DEHP, DOP and total PE levels were associated with indices of dampness, and high DOP was associated with humidifier use. In conclusion, six PEs are ubiquitous in urban settled house dust in Nanjing, China, and both plastic materials and cosmetic and personal care products are important sources. Flooring material, dampness and humidifier use potentially influence house dust PE levels.

  18. Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes.

    Science.gov (United States)

    Vojta, P J; Randels, S P; Stout, J; Muilenberg, M; Burge, H A; Lynn, H; Mitchell, H; O'Connor, G T; Zeldin, D C

    2001-01-01

    House dust mite allergen exposure is a postulated risk factor for allergic sensitization, asthma development, and asthma morbidity; however, practical and effective methods to mitigate these allergens from low-income, urban home environments remain elusive. The purpose of this study was to assess the feasibility and effectiveness of physical interventions to mitigate house dust mite allergens in this setting. Homes with high levels of house dust mite allergen (Der f 1 + Der p 1 > or = 10 microg/g dust by enzyme-linked immunosorbent assay) in the bed, bedroom carpet, and/or upholstered furniture were enrolled in the study. Carpets and upholstered furniture were subjected to a single treatment of either dry steam cleaning plus vacuuming (carpet only) or intensive vacuuming alone. Bed interventions consisted of complete encasement of the mattress, box spring, and pillows plus either weekly professional or in-home laundering of nonencased bedding. Dust samples were collected at baseline and again at 3 days (carpet and upholstery only) and 2, 4, and 8 weeks posttreatment. We compared pretreatment mean allergen concentrations and loads to posttreatment values and performed between-group analyses after adjusting for differences in the pretreatment means. Both dry steam cleaning plus vacuuming and vacuuming alone resulted in a significant reduction in carpet house dust mite allergen concentration and load (p < 0.05). Levels approached pretreatment values by 4 weeks posttreatment in the intensive vacuuming group, whereas steam cleaning plus vacuuming effected a decrease that persisted for up to 8 weeks. Significant decreases in bed house dust mite allergen concentration and load were obtained in response to encasement and either professional or in-home laundering (p < 0.001). Between-group analysis revealed significantly less postintervention house dust mite allergen load in professionally laundered compared to home-laundered beds (p < 0.05). Intensive vacuuming and dry

  19. POLYBROMINATED DIPHENYL ETHERS AND ALTERNATIVE FLAME RETARDANTS IN HOUSE DUST IN DENMARK – LEVELS, PATTERNS AND CHANGES OVER TIME

    DEFF Research Database (Denmark)

    Vorkamp, Katrin; Frederiksen, Marie; Nielsen, Jesper Bo;

    2016-01-01

    House dust has been recognized as a source of exposure to polybrominated diphenyl ethers (PBDEs), in particular for children [1]. Since the EU ban of the commercial PBDE Penta- and OctaBDE mixtures in 2004 and the regulation of DecaBDE through the EU Restriction of Hazardous Substances (Ro......HS) Directive, replacements might have been in use [2]. Building on our previous results on PBDEs in house dust from Denmark and associations with perinatal exposure [3], the present study addresses i) PBDE levels in dust sampled in 2014 in comparison with 2007, ii) the occurrence of alternative flame...... previously observed for PBDEs, distributions were skewed with arithmetic means clearly higher than medians, suggesting that exposure might be much above average for certain individuals. Likewise, the FR composition in dust varied, with individual dust samples containing more BEHT-TEBP or BTBPE than DBDPE...

  20. The distribution of dust mite allergen in the houses of patients with asthma

    International Nuclear Information System (INIS)

    Using an inhibition radioimmunoassay for the major allergen from Dermatophagoides pteronyssinus (antigen P1), we studied the distribution of this dust allergen in the houses of patients with asthma. Both bed and floor dust samples contained a wide range of antigen P1, 100 to 100,000 ng/g of fine dust, and this concentration correlated well with the number of mite bodies (r . 0.81, p less than 0.001). We were unable to detect antigen P1 in the air of undisturbed rooms. However, during domestic activity, between 1 and 30 ng were collected on a filter than sampled air for 45 min at 17 L/min. Using a cascade impactor it was shown that greater than 80% of the airborne antigen P1 was associated with particles greater than 10 mu in diameter. Some of the particles containing allergen could be identified because they formed precipitin rings when impacted onto agarose containing rabbit antimite antiserum. These particles had the physical appearance of mite feces, which are the major source of antigen P1 in mite cultures. The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allergen

  1. Human exposure to per- and polyfluoroalkyl substances (PFASs) via house dust in Korea: Implication to exposure pathway.

    Science.gov (United States)

    Tian, Zhexi; Kim, Seung-Kyu; Shoeib, Mahiba; Oh, Jeong-Eun; Park, Jong-Eun

    2016-05-15

    A wide range of per- and polyfluoroalkyl substances (PFASs), including fluorotelomer alcohols (FTOHs), perfluorooctane sulfonamidoethanols (FOSEs), perfluoroalkyl carboxylic acids (PFCAs), and perfluoroalkane sulfonic acids (PFSAs), were measured in fifteen house dust and two nonresidential indoor dust of Korea. Total concentrations of PFASs in house dust ranged from 29.9 to 97.6 ng g(-1), with a dominance of perfluorooctane sulfonic acid (PFOS), followed by 8:2 FTOH, N-Ethyl perfluorooctane sulfonamidoethanol (EtFOSE), perfluoroctanoic acid (PFOA). In a typical exposure scenario, the estimated daily intakes (EDIs) of total PFASs via house dust ingestion were 2.83 ng d(-1) for toddlers and 1.13 ng d(-1) for adults, which were within the range of the mean EDIs reported from several countries. For PFOA and PFOS exposure via house dust ingestion, indirect exposure (via precursors) was a minor contributor, accounting for 5% and 12%, respectively. An aggregated exposure (hereafter, overall-EDIs) of PFOA and PFOS occurring via all pathways, estimated using data compiled from the literature, were 53.6 and 14.8 ng d(-1) for toddlers, and 20.5 and 40.6 ng d(-1) for adults, respectively, in a typical scenario. These overall-EDIs corresponded to 82% (PFOA) and 92% (PFOS) of a pharmacokinetic model-based EDIs estimated from adults' serum data. Direct dietary exposure was a major contributor (>89% of overall-EDI) to PFOS in both toddlers and adults, and PFOA in toddlers. As for PFOA exposure of adults, however direct exposure via tap water drinking (37%) and indirect exposure via inhalation (22%) were as important as direct dietary exposure (41%). House dust-ingested exposure (direct+indirect) was responsible for 5% (PFOS in toddlers) and house-dust ingestion was a minor contributor in this study, but should not be ignored for toddlers' PFOS exposure due to its significance in the worst-case scenario. PMID:26933964

  2. Lead and other elements in house dust of Japanese residences – Source of lead and health risks due to metal exposure

    International Nuclear Information System (INIS)

    The levels of 25 elements in house dust collected from 100 general Japanese residences were measured. Factor analysis was applied on the multi-element data to explore source of Pb (median concentration 49.1 mg/kg) in house dust. Six factors were extracted and Pb was found to have great loading on the fifth factor with Sb and Sn, suggesting solder (Sn), and plastic and metals (Sb) may be the sources of Pb in the house dust of Japanese residences. No significant loading was found on soil-related factors indicating non-significant contribution of Pb in track-in soil. Seven heavy metals (Cd, Cu, Mo, Pb, Sb, Sn, and Zn) were found in house dust at >10 times more condensed than crustal abundance. Health risk of these elements to children via the ingestion of house dust was estimated based on the comparison with tolerable daily intake and found to be non-significant for most of the elements. - Highlights: • Multi-element analysis was carried out for house dust from households in Japan. • Factor analysis was applied on the multivariate data set. • The abundance of lead had a close relationship with antimony and tin in house dust. • Health risk of heavy metals in house dust for children was not serious. - Major source of Pb in house dust of Japanese residences was not track-in soil but unknown materials that contain Pb and Sb and/or Sn

  3. 78 FR 45903 - Native American Housing Assistance and Self-Determination Act of 1996: Negotiated Rulemaking...

    Science.gov (United States)

    2013-07-30

    ... to Native Americans. NAHASDA eliminated several separate assistance programs and replaced them with a... URBAN DEVELOPMENT 24 CFR Chapter IX Native American Housing Assistance and Self-Determination Act of... INFORMATION CONTACT: Rodger J. Boyd, Deputy Assistant Secretary for Native American Programs, Office of...

  4. 76 FR 71474 - Native American Housing Assistance and Self-Determination Reauthorization Act of 2008: Amendments...

    Science.gov (United States)

    2011-11-18

    ... assistance is provided to Native Americans. NAHASDA eliminated several separate assistance programs and... URBAN DEVELOPMENT 24 CFR Part 1000 RIN 2577-AC80 Native American Housing Assistance and Self... the procedures of the Negotiated Rulemaking Act of 1990, pursuant to the Native American...

  5. Lead speciation in indoor dust: a case study to assess old paint contribution in a Canadian urban house

    Energy Technology Data Exchange (ETDEWEB)

    Beauchemin, Suzanne; MacLean, Lachlan C.W.; Rasmussen, Pat E. (Health Canada); (NRC)

    2012-10-23

    Residents in older homes may experience increased lead (Pb) exposures due to release of lead from interior paints manufactured in past decades, especially pre-1960s. The objective of the study was to determine the speciation of Pb in settled dust from an urban home built during WWII. X-ray absorption near-edge structure (XANES) and micro-X-ray diffraction (XRD) analyses were performed on samples of paint (380-2,920 mg Pb kg{sup -1}) and dust (200-1,000 mg Pb kg{sup -1}) collected prior to renovation. All dust samples exhibited a Pb XANES signature similar to that of Pb found in paint. Bulk XANES and micro-XRD identified Pb species commonly found as white paint pigments (Pb oxide, Pb sulfate, and Pb carbonate) as well as rutile, a titanium-based pigment, in the <150 {micro}m house dust samples. In the dust fraction <36 {micro}m, half of the Pb was associated with the Fe-oxyhydroxides, suggesting additional contribution of outdoor sources to Pb in the finer dust. These results confirm that old paints still contribute to Pb in the settled dust for this 65-year-old home. The Pb speciation also provided a clearer understanding of the Pb bioaccessibility: Pb carbonate > Pb oxide > Pb sulfate. This study underscores the importance of taking precautions to minimize exposures to Pb in house dust, especially in homes where old paint is exposed due to renovations or deterioration of painted surfaces.

  6. Evaluation of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy.

    Science.gov (United States)

    Harmanci, Koray; Razi, Cem H; Toyran, Muge; Kanmaz, Gozde; Cengizlier, Mehmet R

    2010-03-01

    Specific immunotherapy (SIT) is one of the treatment modalities recomended for the management of asthma and allergic rhinitis by international guidelines. A potential benefit of immunotherapy (IT) is to prevent the development of sensitisation to new allergens. There is stil no conclusion on this subject. One hundred twenty-two children 8-18 years old with intermittent asthma, with or without allergic rhinitis, all of whom were monosensitised to house dust mite (HDM) were selected. Sixty two of these children accepted to receive SIT with HDM extract for 4 years and the remaining 60 did not accept SIT and were treated with asthma medications only. This second group of children served as the control group. At the end of the 4-year study period, 36 of the 53 patients (67.9%) in the SIT group showed no new sensitizations, compared to 38 of 52 (73.0%) in the control group (p = 0.141). The most frequent new sensitizations at the end of the study were pollens, grasses and olive polen, followed by animal dander, alternaria and cockroach. In conclusion, SIT may not prevent the onset of new sensitizations in asthmatic children monosensitized to house dust mites. Further investigation is required to clarify the immunologic mechanisms and other factors by which SIT reduces or not the development of new sensitizations in monosensitized children. PMID:20527510

  7. Lead, arsenic and polycyclic aromatic hydrocarbons in soil and house dust in Sydney Nova Scotia

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, T.W. [Calgary Univ., AB (Canada); Lane, S. [York Univ., Toronto, ON (Canada). School of Environmental Studies

    2003-04-01

    This paper presents the results of a lead and arsenic soil and dust study conducted in Sydney, Nova Scotia in August 2002. Whitney Pier, Ashby and North End are 3 communities surrounding the Sydney tar ponds, steel and coke oven sites that have been significantly impacted by the industrial activity of the past century. Lead and arsenic was found in the floor dust of every home evaluated. The neighbourhoods were also found to be contaminated with polycyclic aromatic hydrocarbons (PAHs). There is a low but significant health risk from exposure to lead and arsenic in the soil and house dust, and all three communities must be remediated to prevent health impacts. This report by the Sierra Club criticizes an earlier report by the Joint Action Group (JAG), a tri-governmental process which never took into consideration the fact that people's yards and homes are contaminated and need to be remediated. This report criticizes that the JAG report neglected the issue of people's health and is calling on the federal Health Minister to take action on the environmental disaster. 17 refs., 8 tabs., 1 fig.

  8. The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen

    DEFF Research Database (Denmark)

    Meno, Kåre; Thorsted, Peter B; Ipsen, Henrik;

    2005-01-01

    Allergy to house dust mite is among the most prevalent allergic diseases worldwide. Most house dust mite allergic patients react to Der p 1 from Dermatophagoides pteronyssinus, which is a cysteine protease. To avoid heterogeneity in the sample used for crystallization, a modified recombinant...... molecule was produced. The sequence of the proDer p 1 allergen was modified to reduce glycosylation and to abolish enzymatic activity. The resulting rproDer p 1 preparation was homogenous and stable and yielded crystals diffracting to a resolution of 1.61 A. The active site is located in a large cleft on...... substrates. Sequence variations in related species are concentrated on the surface, which explains the existence of cross-reacting and species-specific antibodies. This study describes the first crystal structure of one of the clinically most important house dust mite allergens, the cysteine protease Der p 1....

  9. Exposure assessment to airborne endotoxin, dust, ammonia, hydrogen sulfide and carbon dioxide in open style swine houses.

    Science.gov (United States)

    Chang, C W; Chung, H; Huang, C F; Su, H J

    2001-08-01

    Information is limited for the exposure levels of airborne hazardous substances in swine feed buildings that are not completely enclosed. Open-style breeding, growing and finishing swine houses in six farms in subtropical Taiwan were studied for the airborne concentrations of endotoxin, dust, ammonia, hydrogen sulfide and carbon dioxide. The air in the farrowing and nursery stalls as partially enclosed was also simultaneously evaluated. Three selected gases and airborne dusts were quantified respectively by using Drager diffusion tubes and a filter-weighing method. Endotoxin was analyzed by the Limulus amoebocyte lysate assay. Average concentration of airborne total endotoxin among piggeries was between 36.8 and 298 EU/m(3), while that for respirable endotoxin was 14.1-129 EU/m(3). Mean concentration of total dust was between 0.15 and 0.34 mg/m(3), with average level of respirable dust of 0.14 mg/m(3). The respective concentrations of NH3, CO2 and H2S were less than 5 ppm, 600-895 ppm and less than 0.2 ppm. Airborne concentrations of total dust and endotoxin in the nursery house were higher than in the other types of swine houses. The finishing house presented the highest exposure risk to NH3, CO2 and H2S. Employees working in the finishing stalls were also exposed to the highest airborne levels of respirable endotoxin and dust. On the other hand, the air of the breeding units was the least contaminated in terms of airborne endotoxin, dust, NH3, CO2 and H2S. The airborne concentrations of substances measured in the present study were all lower than most of published studies conducted in mainly enclosed swine buildings. Distinct characteristics, including maintaining swine houses in an open status and frequent spraying water inside the stalls, significantly reduce accumulation of gases and airborne particulates. PMID:11513795

  10. Exposure of U.S. Children to Residential Dust Lead, 1999–2004: I. Housing and Demographic Factors

    OpenAIRE

    Gaitens, Joanna M.; Dixon, Sherry L.; Jacobs, David E.; Nagaraja, Jyothi; Strauss, Warren; Wilson, Jonathan W.; Ashley, Peter J.

    2008-01-01

    Background Lead-contaminated house dust is a major source of lead exposure for children in the United States. In 1999–2004, the National Health and Nutrition Examination Survey (NHANES) collected dust lead (PbD) loading samples from the homes of children 12–60 months of age. Objectives In this study we aimed to compare national PbD levels with existing health-based standards and to identify housing and demographic factors associated with floor and windowsill PbD. Methods We used NHANES PbD da...

  11. House dust mite allergen Der f enhanced bronchial epithelial cell cytokine expression

    Institute of Scientific and Technical Information of China (English)

    BAO QING SUN; WEI TANG; ALBERT CHAN; ADRIAN WU; NAN SHAN ZHONG

    2006-01-01

    The house dust mites ( Dermatophagoides farinae, Der f) are the major source of aeroallergens implicated in the expression of atopic disorders, including asthma, allergic rhinitis and atopic dermatitis. In particular, strong circumstantial evidence suggests that house dust mite antigens are important precipitating factors of asthma. Many house dust mite allergens are proteases that can elicit airway inflammation by stimulating the release of cytokines from bronchial epithelial cells. To investigate whether Derf allergen proteases induced cytokine production from the epithelial cell line BEAS-2B,BEAS-2B cells were cultured with 4 different concentrations of Derf (0.02, 0.2, 2, 20 μg/ml) for 24-96 h, after which supernatants were assayed for interleukin (IL)-6 and IL-8 with ELISA. Reverse transcription-PCR was also performed. The cell sheets were intact throughout the observation in control group without any exposure to Derf antigen. In the experimental groups cells treated with Der f allergen showed changes in the anchorage status of the monolayer. There was a significant increase in the level of cytokine production compared with the untreated sample. The release of IL-6 and IL-8 increased in a concentration-dependent manner ( P < 0.05, respectively) with the addition of increasing dosage of Der f to the cell sheets. Levels of IL-6 and IL-8 began to rise at 24 h and 48 h after allergen exposure, and they increased significantly in the supernatants at 72 h and 96 h. At the same time the concentration dependence of induction of IL-6 and IL-8 expression as well as an increase in the expression of IL-6 and IL-8 mRNA manifested evidently. HDM-induced airway inflammation may include Der f-mediated release of inflammatory mediators, and the proteolytic activity of an allergen may stimulate the release of proinflammatory cytokines from human bronchial epithelium. It is suggested that IL-6 and IL-8 production by bronchial epithelial cells may play a role in the

  12. Air Quality in Alternative Housing Systems May Have an Impact on Laying Hen Welfare. Part I—Dust

    Science.gov (United States)

    David, Bruce; Oppermann Moe, Randi; Michel, Virginie; Lund, Vonne; Mejdell, Cecilie

    2015-01-01

    The new legislation for laying hens in the European Union put a ban on conventional cages. Production systems must now provide the hens with access to a nest, a perch, and material for dust bathing. These requirements will improve the behavioral aspects of animal welfare. However, when hens are kept with access to litter, it is a concern that polluted air may become an increased threat to health and therefore also a welfare problem. This article reviews the literature regarding the health and welfare effects birds experience when exposed to barn dust. Dust is composed of inorganic and organic compounds, from the birds themselves as well as from feed, litter, and building materials. Dust may be a vector for microorganisms and toxins. In general, studies indicate that housing systems where laying hens have access to litter as aviaries and floor systems consistently have higher concentrations of suspended dust than caged hens with little (furnished cages) or no access to litter (conventional cages). The higher dust levels in aviaries and floor housing are also caused by increased bird activity in the non-cage systems. There are gaps in both the basic and applied knowledge of how birds react to dust and aerosol contaminants, i.e., what levels they find aversive and/or impair health. Nevertheless, high dust levels may compromise the health and welfare of both birds and their caretakers and the poor air quality often found in new poultry housing systems needs to be addressed. It is necessary to develop prophylactic measures and to refine the production systems in order to achieve the full welfare benefits of the cage ban. PMID:26479370

  13. Air Quality in Alternative Housing Systems May Have an Impact on Laying Hen Welfare. Part I—Dust

    Directory of Open Access Journals (Sweden)

    Bruce David

    2015-07-01

    Full Text Available The new legislation for laying hens in the European Union put a ban on conventional cages. Production systems must now provide the hens with access to a nest, a perch, and material for dust bathing. These requirements will improve the behavioral aspects of animal welfare. However, when hens are kept with access to litter, it is a concern that polluted air may become an increased threat to health and therefore also a welfare problem. This article reviews the literature regarding the health and welfare effects birds experience when exposed to barn dust. Dust is composed of inorganic and organic compounds, from the birds themselves as well as from feed, litter, and building materials. Dust may be a vector for microorganisms and toxins. In general, studies indicate that housing systems where laying hens have access to litter as aviaries and floor systems consistently have higher concentrations of suspended dust than caged hens with little (furnished cages or no access to litter (conventional cages. The higher dust levels in aviaries and floor housing are also caused by increased bird activity in the non-cage systems. There are gaps in both the basic and applied knowledge of how birds react to dust and aerosol contaminants, i.e., what levels they find aversive and/or impair health. Nevertheless, high dust levels may compromise the health and welfare of both birds and their caretakers and the poor air quality often found in new poultry housing systems needs to be addressed. It is necessary to develop prophylactic measures and to refine the production systems in order to achieve the full welfare benefits of the cage ban.

  14. 78 FR 7443 - Request for Comment on the Redesign of the American Housing Survey

    Science.gov (United States)

    2013-02-01

    ... response rates in both face-to-face and telephone surveys? How should questions be formulated differently... URBAN DEVELOPMENT Request for Comment on the Redesign of the American Housing Survey AGENCY: Office of... Housing Survey (AHS) for 2015 and later years. As part of this redesign, HUD is soliciting public...

  15. Molecular Determinants for Antibody Binding on Group 1 House Dust Mite Allergens

    Energy Technology Data Exchange (ETDEWEB)

    Chruszcz, Maksymilian; Pomés, Anna; Glesner, Jill; Vailes, Lisa D.; Osinski, Tomasz; Porebski, Przemyslaw J.; Majorek, Karolina A.; Heymann, Peter W.; Platts-Mills, Thomas A.E.; Minor, Wladek; Chapman, Martin D. (INDOOR Bio.); (UV); (UVHS)

    2012-07-11

    House dust mites produce potent allergens, Der p 1 and Der f 1, that cause allergic sensitization and asthma. Der p 1 and Der f 1 are cysteine proteases that elicit IgE responses in 80% of mite-allergic subjects and have proinflammatory properties. Their antigenic structure is unknown. Here, we present crystal structures of natural Der p 1 and Der f 1 in complex with a monoclonal antibody, 4C1, which binds to a unique cross-reactive epitope on both allergens associated with IgE recognition. The 4C1 epitope is formed by almost identical amino acid sequences and contact residues. Mutations of the contact residues abrogate mAb 4C1 binding and reduce IgE antibody binding. These surface-exposed residues are molecular targets that can be exploited for development of recombinant allergen vaccines.

  16. Gene silencing by RNA interference in the house dust mite, Dermatophagoides pteronyssinus.

    Science.gov (United States)

    Marr, Edward J; Sargison, Neil D; Nisbet, Alasdair J; Burgess, Stewart T G

    2015-12-01

    This is the first report of gene silencing by RNA interference (RNAi) in the European house dust mite, Dermatophagoides pteronyssinus, Trouessart, 1897. Using a non-invasive immersion method first developed for the honey bee mite, Varroa destructor, a significant reduction in the expression of D. pteronyssinus glutathione-S-transferase mu-class 1 enzyme (DpGST-mu1) was achieved following overnight immersion in double stranded RNA encoding DpGST-mu1. Although no detrimental phenotypic changes were observed following silencing, this technique can now be used to address fundamental physiological questions and assess the potential therapeutic benefit in silencing D. pteronyssinus target genes in selected domestic situations of high human-mite interface. PMID:26212476

  17. Requirements for acquiring a high-quality house dust mite extract for allergen immunotherapy

    Directory of Open Access Journals (Sweden)

    Frati F

    2012-05-01

    Full Text Available Franco Frati,1 Cristoforo Incorvaia,2 Marie David,3 Silvia Scurati,3 Simona Seta,4 Guglielmo Padua,4 Eleonora Cattaneo,1 Carlo Cavaliere,5 Alessia Di Rienzo,6 Ilaria Dell'Albani,1 Paola Puccinelli11Medical and Scientific and Regulatory Department, Stallergenes, Milan, Italy; 2Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, Italy; 3Laboratoire Stallergenes, Antony, France; 4Marketing Department, Stallergenes, Milan, Italy; 5Ear, Nose and Throat Department, University Sapienza, Rome, Italy; 6Azienda Sanitaria Locale, Allergology Service, Frosinone, ItalyAbstract: The house dust mite is a major cause of respiratory allergy worldwide. The management of mite allergy is based on avoidance measures, drug treatment, and allergen immunotherapy, but only allergen immunotherapy is able to modify the natural history of the disease. Injectable subcutaneous immunotherapy was introduced a century ago, while sublingual immunotherapy was proposed in the 1980s and emerged in the ensuing years as an effective and safe option to subcutaneous immunotherapy. However, the quality of the extracts to be used in allergen immunotherapy is crucial for the success of treatment. The mite extract for sublingual immunotherapy known as Staloral 300 was developed to offer optimal characteristics concerning the mite culture medium, standardization, and allergen dose. Double-blind, placebo-controlled trials with Staloral 300 have provided a substantial part of the clinical evidence analyzed in a meta-analysis of the efficacy of allergen immunotherapy in mite-induced rhinitis and asthma. Safety and tolerability are very good, mild local reactions in the mouth being the most common side effect. This makes it feasible to carry out sublingual immunotherapy for the 3–5-year duration needed to achieve long-lasting tolerance to the specific allergen. The performance of Staloral 300 may provide optimal conditions for an effective and safe sublingual immunotherapy in patients with

  18. Optimization of a Der p 2-based prophylactic DNA vaccine against house dust mite allergy.

    Science.gov (United States)

    Pulsawat, Pinya; Pitakpolrat, Patrawadee; Prompetchara, Eakachai; Kaewamatawong, Theerayuth; Techakriengkrai, Navapon; Sirivichayakul, Sunee; Buranapraditkun, Supranee; Hannaman, Drew; Ruxrungtham, Kiat; Jacquet, Alain

    2013-03-01

    DNA vaccines encoding allergens are promising immunotherapeutics to prevent or to treat allergy through induction of allergen-specific Th1 responses. Despite anti-allergy effects observed in small rodents, DNA-based vaccines are weak immunogens in primates and humans and particularly when administered by conventional injection. The goal of the present study was to improve the immunogenicity of a prophylactic vaccine encoding the major house dust mite allergen Der p 2. In this context, we evaluated the influence of different DNA backbones including notably intron and CpG enriched sequence, the DNA dose, the in vivo delivery by electroporation as well as the heterologous prime boost regimen on the vaccine efficiency. We found that a minimal allergen expression level threshold must be reached to induce the production of specific antibodies but beyond this limit, the intensity of the immune response was independent on the DNA dose and allergen expression. The in vivo DNA delivery by electroporation drastically enhanced the production of specific antibodies but not the IFNg secretion. Vaccination of naïve mice with DNA encoding Der p 2 delivered by electroporation even at very low dose (2μg) prevented the development of house dust mite allergy through Th1-skewed immune response characterized by the drastic reduction of allergen-specific IgE, IL-5 and lung inflammation together with the induction of strong specific IgG2a titers and IFNg secretion. CpG cassette in the DNA backbone does not play a critical role in the efficient prophylaxis. Finally, comparable protective immune responses were observed when using heterologous DNA prime/protein boost or homologous DNA prime/boost. Taken together, these data suggest that the potent Th1 response induced by DNA-based vaccine encoding allergens through electroporation provides the rationale for the evaluation of DNA encoding Der p 2 into HDM allergy clinical trials. PMID:23396105

  19. Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis

    Czech Academy of Sciences Publication Activity Database

    Banerjee, S.; Resch, Y.; Chen, K. W.; Swoboda, I.; Focke-Tejkl, M.; Blatt, K.; Novak, N.; Wickman, M.; van Hage, M.; Ferrara, R.; Mari, A.; Purohit, A.; Pauli, G.; Sibanda, E. N.; Ndlovu, P.; Thomas, W. R.; Krzyžánek, Vladislav; Tacke, S.; Malkus, U.; Valent, P.; Valenta, R.; Vrtala, S.

    2015-01-01

    Roč. 135, č. 1 (2015), s. 102-109. ISSN 0022-202X R&D Projects: GA MŠk(CZ) LO1212 Institutional support: RVO:68081731 Keywords : allergen * house dust mites * immunogold electron microscopy Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 7.216, year: 2014

  20. House dust mite allergen level and allergen sensitization as risk factors for asthma among student in Central Jakarta

    Directory of Open Access Journals (Sweden)

    Heru Sundaru

    2006-03-01

    Full Text Available This study is a community-based study to get an overview about House Dust Mite (HDM allergen level, allergen sensitization as risk factors of asthma. This is a cross-sectional study on 3,840 students from 19 junior high schools, aged 13-14 years. All of the respondents filled out the International Study on Asthma and Allergy in Children (ISAAC questionnaire. Of 3840 respondents, 288 (7.5% were assigned to asthma group (experience wheezing during the last 12 months. The skin prick test was performed on 207 respondents and the house dust mite was collected from 135 respondents. Of 2601 respondents in non-asthma group, the skin prick test was randomly performed on 274 respondents and the house dust mite was collected from 165 respondents. There is no significant difference on HDM allergen concentration for Der p1, Der f1 or Group I between asthma and control group. The risk of asthma was caused especially by sen D.pteronyssinus (crude odds ration (OR: 12.68, 95% confidence interval (CI: 7.50-21.44, D.farinae (OR: 10.50, CI: 6.35-17.34 and cockroach allergen (OR:5.57, CI:3.44-9.01. The risk for asthma was not correlated with the level of house dust mite allergens but its sensitization. In conclusion, sensitization to HDM and cockroach allergen should be concerned in order to reduce risk and prevalence of asthma. (Med J Indones 2006; 15:55-9Keywords: house dust mite, allergen sensitization, asthma, risk factor

  1. Housing Quality Gap for Minorities and Immigrants in the U.S.: Evidence from the 2009 American Housing Survey

    OpenAIRE

    Kusum Mundra; Amarendra Sharma

    2013-01-01

    Using the data from the national American Housing Survey for the year 2009 this paper examines the housing quality gap for minorities and immigrants. Using logit model this paper finds that there is a significant quality gap for Blacks and Hispanics when compared to whites in the U.S. but not for immigrants relative to natives. The home quality has not changed over time among the homeowners in the U.S. However for immigrant homeowners the home quality dropped during the 1980s, potentially due...

  2. 77 FR 39452 - Native American Housing Assistance and Self-Determination Act of 1996: Notice of Intent To...

    Science.gov (United States)

    2012-07-03

    ... assistance is provided to Native Americans. NAHASDA eliminated several separate assistance programs and... URBAN DEVELOPMENT 24 CFR Chapter IX Native American Housing Assistance and Self-Determination Act of... Grant (IHBG) program authorized under the Native American Housing Assistance and Self-Determination...

  3. 75 FR 423 - Native American Housing Assistance and Self-Determination Reauthorization Act of 2008: Notice of...

    Science.gov (United States)

    2010-01-05

    ... Americans. NAHASDA eliminated several separate assistance programs and replaced them with a single block... URBAN DEVELOPMENT Native American Housing Assistance and Self-Determination Reauthorization Act of 2008... develop regulatory changes to programs authorized under the Native American Housing Assistance and...

  4. Mice housed on coal dust-contaminated sand: A model to evaluate the impacts of coal mining on health.

    Science.gov (United States)

    Caballero-Gallardo, Karina; Olivero-Verbel, Jesus

    2016-03-01

    Coal dust is the most important air pollutant in coal mining in regards to producing deleterious health effects. It permeates the surrounding environment threatening public health. The aim of this study was to evaluate the toxic effects associated with exposure to sand contaminated with coal dust particles below 38μm in diameter, obtained from a mineral sample collected in the largest coal mine in South America, La Loma, Cesar, Colombia. Sterilized sand was spiked with coal dust to obtain concentrations ranging from zero to 4% coal dust. To model natural exposure, mice were housed for eight weeks in boxes containing this mixture as bedding after which, they were euthanized and blood and tissue samples were collected. Real time PCR analysis revealed an increase in Cyp1A1 mRNA for living on sand with coal dust concentrations greater than 2% compared to mice living on sand without coal dust. Unexpectedly, for mice on coal dust-polluted sand, Sod1, Scd1 and Nqo1 hepatic mRNA were downregulated. The Comet assay in peripheral blood cells and the micronucleus test in blood smears, showed a significant potential genotoxic effect only at the highest coal dust concentration. Histopathological analysis revealed vascular congestion and peribronchial inflammation in the lungs. A dose-response relationship for the presence of hepatic steatosis, vacuolization and nuclei enlargements was observed in the exposed animals. The data suggest living on a soil polluted with coal dust induces molecular, cellular and histopathological changes in mice. Accordingly, the proposed model can be used to identify deleterious effects of exposure to coal dust deposited in soils that may pose health risks for surrounding wildlife populations. PMID:26774687

  5. A study on the optimal design of a cyclone system for vacuum cleaner with the consideration of house dust

    International Nuclear Information System (INIS)

    Cyclone, a type of particle collector widely used in the field of ambient sampling and industrial particulate control, is the principal type of gas-solids separator that use a centrifugal force. The goal of this study is to transform conventional cyclone into a new type of cyclone that can be used for the household vacuum cleaners. To meet the goal, first, the analysis about local environment and dust is carried out. Second, it must have enough high-efficiency not to reduce suction power due to clogging of exhaust filter unit. Two single cyclones with central-hopper-dust-outlet and side-wall-dust-outlet and a twin cyclone are designed and fabricated to evaluate, and compare, their dust collection efficiencies and pressure drops. The measurements of separation efficiency for dust by using DMT test dust type 08 are carried out. House dust experiment is additionally performed to check the local matters applicability such as tissue papers, fur and hairs. The collection efficiency of the twin cyclone is found to be 3-6% greater than those of two single cyclones with the same body diameter, inlet and inner cylinder diameter. Twin cyclone with a large body diameter, a small inner cylinder diameter, a short inner cylinder, a narrow inlet has high separation efficiency. This result indicates the possibility of achieving higher collection efficiencies with a twin cyclone

  6. Canadian House Dust Study: Population-based concentrations, loads and loading rates of arsenic, cadmium, chromium, copper, nickel, lead, and zinc inside urban homes

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, Pat E. [Exposure and Biomonitoring Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Ottawa, ON, Canada K1A 0K9 (Canada); Department of Earth Sciences, University of Ottawa, 140 Louis Pasteur, Ottawa, ON, Canada K1N 6N5 (Canada); Levesque, Christine [Exposure and Biomonitoring Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Ottawa, ON, Canada K1A 0K9 (Canada); Chénier, Marc; Gardner, H. David [Exposure and Biomonitoring Division, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Ottawa, ON, Canada K1A 0K9 (Canada); Department of Earth Sciences, University of Ottawa, 140 Louis Pasteur, Ottawa, ON, Canada K1N 6N5 (Canada); Jones-Otazo, Heather [Regions and Programs Branch, Health Canada, 180 Queen Street West, Toronto, ON, Canada M5V 3L7 (Canada); Petrovic, Sanya [Contaminated Sites Division, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Ave West, Ottawa, ON, Canada K1A 0K9 (Canada)

    2013-01-15

    The Canadian House Dust Study was designed to obtain nationally representative urban house dust metal concentrations (μg g{sup −1}) and metal loadings (μg m{sup −2}) for arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), lead (Pb), and zinc (Zn). Consistent sampling of active dust of known age and provenance (area sampled) also permitted the calculation of indoor loading rates (mg m{sup −2} day{sup −1} for dust and μg m{sup −2} day{sup −1} for metals) for the winter season (from 2007 to 2010) when houses are most tightly sealed. Geomean/median indoor dust loading rates in homes located more than 2 km away from industry of any kind (9.6/9.1 mg m{sup −2} day{sup −1}; n = 580) were significantly lower (p < .001) than geomean (median) dust loading rates in homes located within 2 km of industry (13.5/13.4 mg m{sup −2} day{sup −1}; n = 421). Proximity to industry was characterized by higher indoor metal loading rates (p < .003), but no difference in dust metal concentrations (.29 ≥ p ≤ .97). Comparisons of non-smokers' and smokers' homes in non-industrial zones showed higher metal loading rates (.005 ≥ p ≤ .038) in smokers' homes, but no difference in dust metal concentrations (.15 ≥ p ≤ .97). Relationships between house age and dust metal concentrations were significant for Pb, Cd and Zn (p < .001) but not for the other four metals (.14 ≥ p ≤ .87). All seven metals, however, displayed a significant increase in metal loading rates with house age (p < .001) due to the influence of higher dust loading rates in older homes (p < .001). Relationships between three measures of metals in house dust – concentration, load, and loading rate – in the context of house age, smoking behavior and urban setting consistently show that concentration data is a useful indicator of the presence of metal sources in the home, whereas dust mass is the overriding influence on metal loadings and loading rates

  7. CO2 sequestration using accelerated gas-solid carbonation of pre-treated EAF steel-making bag house dust.

    Science.gov (United States)

    El-Naas, Muftah H; El Gamal, Maisa; Hameedi, Suhaib; Mohamed, Abdel-Mohsen O

    2015-06-01

    Mineral CO2 sequestration is a promising process for the reduction of carbon dioxide emissions to the atmosphere. In this paper, alkaline calcium-rich dust particles collected from bag filters of electric arc furnaces (EAF) for steel making were utilized as a viable raw material for mineral CO2 sequestration. The dust particles were pre-treated through hydration, drying and screening. The pre-treated particles were then subjected to direct gas-solid carbonation reaction in a fluidized-bed reactor. The carbonated products were characterized to determine the overall sequestration capacity and the mineralogical structures. Leaching tests were also performed to measure the extracted minerals from the carbonated dust and evaluate the carbonation process on dust stabilization. The experimental results indicated that CO2 could be sequestered using the pre-treated bag house dust. The maximum sequestration of CO2 was 0.657 kg/kg of dust, based on the total calcium content. The highest degree of carbonation achieved was 42.5% and the carbonation efficiency was 69% at room temperature. PMID:25846002

  8. Home dampness, fungi and house dust mites, and respiratory symptoms in children

    NARCIS (Netherlands)

    A.P. Verhoeff (Arnoud Paul)

    1994-01-01

    textabstractDamp houses are common in the Netherlands. A study conducted in 1985 at the request of the Ministry of Housing, Physical Planning and Environment, among housing corporations that managed 1.6 million houses (almost one third of the total housing stock in the Netherlands at that time) show

  9. Too big to be noticed: cryptic invasion of Asian camel crickets in North American houses

    OpenAIRE

    Mary Jane Epps; Menninger, Holly L.; Nathan LaSala; Dunn, Robert R.

    2014-01-01

    Despite the rapid expansion of the built environment, we know little about the biology of species living in human-constructed habitats. Camel crickets (Rhaphidophoridae) are commonly observed in North American houses and include a range of native taxa as well as the Asian Diestrammena asynamora (Adelung), a species occasionally reported from houses though considered to be established only in greenhouses. We launched a continental-scale citizen science campaign to better understand the relativ...

  10. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling.

    Science.gov (United States)

    Johnson, Jill R; Wiley, Ryan E; Fattouh, Ramzi; Swirski, Filip K; Gajewska, Beata U; Coyle, Anthony J; Gutierrez-Ramos, José-Carlos; Ellis, Russ; Inman, Mark D; Jordana, Manel

    2004-02-01

    It is now fully appreciated that asthma is a disease of a chronic nature resulting from intermittent or continued aeroallergen exposure leading to airway inflammation. To investigate responses to continuous antigen exposure, mice were exposed to either house dust mite extract (HDM) or ovalbumin intranasally for five consecutive days, followed by 2 days of rest, for up to seven consecutive weeks. Continuous exposure to HDM, unlike ovalbumin, elicited severe and persistent eosinophilic airway inflammation. Flow cytometric analysis demonstrated an accumulation of CD4+ lymphocytes in the lung with elevated expression of inducible costimulator a marker of T cell activation, and of T1/ST2, a marker of helper T Type 2 effector cells. We also detected increased and sustained production of helper T cell Type 2-associated cytokines by splenocytes of HDM-exposed mice on in vitro HDM recall. Histologic analysis of the lung showed evidence of airway remodeling in mice exposed to HDM, with goblet cell hyperplasia, collagen deposition, and peribronchial accumulation of contractile tissue. In addition, HDM-exposed mice demonstrated severe airway hyperreactivity to methacholine. Finally, these responses were studied for up to 9 weeks after cessation of HDM exposure. We observed that whereas airway inflammation resolved fully, the remodeling changes did not resolve and airway hyperreactivity resolved only partly. PMID:14597485

  11. Induction of vascular remodeling in the lung by chronic house dust mite exposure.

    Science.gov (United States)

    Rydell-Törmänen, Kristina; Johnson, Jill R; Fattouh, Ramzi; Jordana, Manel; Erjefält, Jonas S

    2008-07-01

    Structural changes to the lung are associated with chronic asthma. In addition to alterations to the airway wall, asthma is associated with vascular modifications, although this aspect of remodeling is poorly understood. We sought to evaluate the character and kinetics of vascular remodeling in response to chronic aeroallergen exposure. Because many ovalbumin-driven models used to investigate allergic airway disease do so in the absence of persistent airway inflammation, we used a protocol of chronic respiratory exposure to house dust mite extract (HDME), which has been shown to induce persistent airway inflammation consistent with that seen in humans with asthma. Mice were exposed to HDME intranasally for 7 or 20 consecutive weeks, and resolution of the inflammatory and remodeling response to allergen was investigated 4 weeks after the end of a 7-week exposure protocol. Measures of vascular remodeling, including total collagen deposition, procollagen I production, endothelial and smooth muscle cell proliferation, smooth muscle area, and presence of myofibroblasts, were investigated histologically in lung vessels of different sizes and locations. We observed an increase in total collagen content, which did not resolve upon cessation of allergen exposure. Other parameters were significantly increased after 7 and/or 20 weeks of allergen exposure but returned to baseline after allergen withdrawal. We conclude that respiratory HDME exposure induces airway remodeling and pulmonary vascular remodeling, and, in accordance with airway remodeling, some components of these structural changes may be irreversible. PMID:18314535

  12. Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet

    Directory of Open Access Journals (Sweden)

    Marie-Eve eDumez

    2014-03-01

    Full Text Available In more than 20% of the world population, sensitization to house dust mite (HDM allergens triggers typical allergic diseases such as allergic rhinitis and asthma. Amongst the 23 mite allergen groups hitherto identified, groups 1 are cysteine proteases belonging to the papain-like family whereas groups 3, 6 and 9 are serine proteases displaying trypsin, chymotrypsin and collagenolytic activities, respectively. While these proteases are more likely to be involved in the mite digestive system, they also play critical roles in the initiation and in the chronicity of the allergic response notably through the activation of innate immune pathways. All these allergenic proteases are expressed in mite as inactive precursor form. Until recently, the exact mechanisms of their maturation into active proteases remained to be fully elucidated. Recent breakthroughs in the understanding of the activation mechanisms of mite allergenic protease precursors have highlighted an uncommon and unique maturation pathway orchestrated by group 1 proteases that tightly regulates the proteolytic activities of groups 1, 3, 6 and 9 through complex intra- or intermolecular mechanisms. This review presents and discusses the currently available knowledge of the activation mechanisms of group 1, 3, 6 and 9 allergens of Dermatophagoides pteronyssinus laying special emphasis on their localization, regulation and interconnection.

  13. Acaricidal activity of Cymbopogon citratus and Azadirachta indica against house dust mites

    Institute of Scientific and Technical Information of China (English)

    Azima Laili Hanifah; Siti Hazar Awang; Ho Tze Ming; Suhaili Zainal Abidin; Maizatul Hashima Omar

    2011-01-01

    Objective: To examine the acaricidal effects of the essential oil of Cymbopogon citratus leaf extract (lemongrass) and ethanolic Azadirachta indica leaf extract (neem) against house dust mites Dermatophagoides farinae (D. farinae) and Dermatophagoides pteronyssinus (D. pteronyssinus). Methods: Twenty-five adults mites were placed onto treated filter paper that is soaked with plant extract and been tested at different concentrations (50.00%, 25.00%, 12.50%, 6.25% and 3.13%) and exposure times (24hrs, 48hrs, 72hrs and 96 hrs). All treatments were replicated 7 times, and the experiment repeated once. The topical and contact activities of the two herbs were investigated.Results:Mortalities from lemongrass extract were higher than neem for both topical and contact activities. At 50 % concentration, both 24 hrs topical and contact exposures to lemongrass resulted in more than 91% mortalities for both species of mites. At the same concentration and exposure time, neem resulted in topical mortalities of 40.3% and 15.7% against D. pteronyssinus and D.farinae respectively; contact mortalities were 8.0% and 8.9% against the 2 mites, respectively. There was no difference in topical mortalities of D. pteronyssinus from exposure to concentrations of lemongrass and neem up to 12.50%; lemongrass was more effective than neem at the higher concentrations. Conclusions: Generally, topical mortalities of D. farinae due to lemongrass are higher than that due to neem. Contact mortalities of lemongrass are always higher that neem against both species of mites.

  14. House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors.

    Science.gov (United States)

    Brown, Alan; Farmer, Kinley; MacDonald, Louise; Kalsheker, Noor; Pritchard, Dave; Haslett, Chris; Lamb, Jonathan; Sallenave, J-M

    2003-09-01

    House dust mites (HDM) are the most common source of aeroallergens and in genetic susceptible individuals can cause symptoms ranging from atopic dermatitis to bronchial asthma. Der p 1, a major target of the human immune responses to HDM, through its enzymatic properties can modulate the adaptive immune system by the cleavage of CD23 and CD25. The consequences of this would be to promote allergic inflammatory responses. Furthermore, by disrupting epithelial tight junctions Der p 1 facilitates the transport of allergen across the epithelium. Here, we report that Der p 1 has additional effects on the innate defense mechanisms of the lung, by inactivating in vitro and ex vivo the elastase inhibitors human (h) alpha1-proteinase inhibitor (h-A1-Pi), mouse (m-), (but not human [h])-SLPI and h-elafin. We confirm that Der p 1 contain both cysteine and serine proteinases, and extend this finding to demonstrate for the first time that h-elafin is particularly sensitive to the biological activity of the latter. Because these elastase inhibitors have antimicrobial, as well as antielastase activity, our results suggest that inactivation of these innate components of the lung defense system by Der p 1 may increase the susceptibility of patients with allergic inflammation to infection. PMID:12689923

  15. Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae.

    Science.gov (United States)

    Wu, Hai-Qiang; Li, Li; Li, Jing; He, Zhen-Dan; Liu, Zhi-Gang; Zeng, Qing-Qian; Wang, Yu-Sheng

    2012-01-01

    This study characterized the acaricidal activity of constituents of patchouli oil extracted from (Pogostemon cablin (Blanco) BENTH) against the house dust mite, Dermatophagoides farinae. A new compound, 2-(1,3-dihydroxy-but-2-enylidene)-6-methyl-3-oxo-heptanoic acid (DHEMH), was isolated from patchouli oil and characterized by (1)H-NMR, (13)C-NMR, LC-MS and elemental analysis (EA). This active component was identified as the hydrolysate of pogostone. Fifteen other constituents found in patchouli oil were also identified by GC-MS, including patchouli alcohol and pogostone. LD(50) studies carried out over 24 h using contact toxicity tests identified DHEMH as the most toxic compound to D. farinae (2.04 μg/cm(2)), followed by patchouli oil (6.11 μg/cm(2)), benzyl benzoate (BP) (9.31 μg/cm(2)) and dibutyl phthalate (DBP) (58.52 μg/cm(2)). In vapor phase toxicity tests, all of these compounds were more effective in closed than open containers, indicating that the most efficient mode of delivery for these compounds is the vapor phase. These results indicate that DHEMH and patchouli oil merit further study as potential agents for the control of D. farinae. PMID:22293476

  16. Acaricidal activities of some essential oils and their monoterpenoidal constituents against house dust mite, Dermatophagoides pteronyssinus (Acari: Pyroglyphidae)

    Institute of Scientific and Technical Information of China (English)

    SAAD El-Zemity; HUSSIEN Rezk; SAHER Farok; AHMED Zaitoon

    2006-01-01

    The acaricidal activities of fourteen essential oils and fourteen of their major monoterpenoids were tested against house dust mites Dermatophagoides pteronyssinus. Five concentrations were used over two different time intervals 24 and 48 h under laboratory conditions. In general, it was noticed that the acaricidal effect based on LC50 of either essential oils or monoterpenoids against the mite was time dependant. The LC50 values were decreased by increasing of exposure time. Clove,matrecary, chenopodium, rosemary, eucalyptus and caraway oils were shown to have high activity. As for the monoterpenoids,cinnamaldehyde and chlorothymol were found to be the most effective followed by citronellol. This study suggests the use of the essential oils and their major constituents as ecofriendly biodegradable agents for the control of house dust mite, D. pteronyssinus.

  17. A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

    OpenAIRE

    Alba Llop-Guevara; Chu, Derek K.; Walker, Tina D; Susanna Goncharova; Ramzi Fattouh; Silver, Jonathan S.; Cheryl Lynn Moore; Xie, Juliana L.; Paul M O'Byrne; Anthony J. Coyle; Roland Kolbeck; Humbles, Alison A.; Martin R Stämpfli; Manel Jordana

    2014-01-01

    Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We ...

  18. Effect of an Air Cleaner with Electrostatic Filter on the Removal of Airborne House Dust Mite Allergens

    OpenAIRE

    Agrawal, Santosh Rani; Kim, Hak-Joon; Lee, Yong Won; Sohn, Jung-Ho; Lee, Jae Hyun; Kim, Yong-Jin; Lee, Sung-Hwa; Hong, Chein-Soo; Park, Jung-Won

    2010-01-01

    Purpose The effects of air cleaners on the removal of airborne indoor allergens, especially house dust mites (HDM), are still controversial. The objective of this study is to evaluate the effect of an air cleaner with an electrostatic filter on the removal of airborne mite allergens. Materials and Methods A dried HDM culture medium that contained mite body particles and excretions was dispersed in a chamber equipped with an electrostatic air cleaner. The number of airborne particles was recor...

  19. Isomer Profiles of Perfluorochemicals in Matched Maternal, Cord, and House Dust Samples: Manufacturing Sources and Transplacental Transfer

    OpenAIRE

    Beesoon, Sanjay; Webster, Glenys M.; Shoeib, Mahiba; Harner, Tom; Benskin, Jonathan P.; Martin, Jonathan W.

    2011-01-01

    Background: Perfluorochemicals (PFCs) are detectable in the general population and in the human environment, including house dust. Sources are not well characterized, but isomer patterns should enable differentiation of historical and contemporary manufacturing sources. Isomer-specific maternal–fetal transfer of PFCs has not been examined despite known developmental toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in rodents. Objectives: We elucidated relative contri...

  20. Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis

    OpenAIRE

    Banerjee, Srinita; Resch, Yvonne; Chen, Kuan-Wei; Swoboda, Ines; Focke-Tejkl, Margit; Blatt, Katharina; Novak, Natalija; Wickman, Magnus; Van Hage, Marianne; Ferrara, Rosetta; Mari, Adriano; Purohit, Ashok; Pauli, Gabrielle; Sibanda, Elopy N.; Ndlovu, Portia

    2014-01-01

    House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia col...

  1. Lead Speciation in House Dust from Canadian Urban Homes Using EXAFS Micro-XRF and Micro-XRD

    Energy Technology Data Exchange (ETDEWEB)

    L MacLean; S Beauchemin; P Rasmussen

    2011-12-31

    X-ray absorption fine-structure (XAFS) spectroscopy, micro-X-ray fluorescence ({mu}XRF), and micro-X-ray diffraction ({mu}XRD) were used to determine the speciation of Pb in house dust samples from four Canadian urban homes having elevated Pb concentrations (>1000 mg Pb kg{sup -1}). Linear combination fitting of the XAFS data, supported by {mu}XRF and {mu}XRD, shows that Pb is complexed in a variety of molecular environments, associated with both the inorganic and organic fractions of the dust samples. The inorganic species of lead identified were as follows: Pb metal, Pb carbonate, Pb hydroxyl carbonate, Pb oxide, and Pb adsorbed to iron oxyhydroxides. Pb carbonate and/or Pb hydroxyl carbonate occurred in all four dust samples and accounted for 28 to 75% of total Pb. Pb citrate and Pb bound to humate were the organic species identified. The results of this study demonstrate the ability of XAFS to identify Pb speciation in house dust and show the potential to identify Pb sources from new homes versus older homes. Understanding Pb speciation and how it influences bioaccessibility is important for human health risk assessment and risk management decisions which aim to improve indoor environmental health.

  2. Lead speciation in house dust from Canadian urban homes using EXAFS, micro-XRF, and micro-XRD.

    Science.gov (United States)

    MacLean, Lachlan C W; Beauchemin, Suzanne; Rasmussen, Pat E

    2011-07-01

    X-ray absorption fine-structure (XAFS) spectroscopy, micro-X-ray fluorescence (μXRF), and micro-X-ray diffraction (μXRD) were used to determine the speciation of Pb in house dust samples from four Canadian urban homes having elevated Pb concentrations (>1000 mg Pb kg(-1)). Linear combination fitting of the XAFS data, supported by μXRF and μXRD, shows that Pb is complexed in a variety of molecular environments, associated with both the inorganic and organic fractions of the dust samples. The inorganic species of lead identified were as follows: Pb metal, Pb carbonate, Pb hydroxyl carbonate, Pb oxide, and Pb adsorbed to iron oxyhydroxides. Pb carbonate and/or Pb hydroxyl carbonate occurred in all four dust samples and accounted for 28 to 75% of total Pb. Pb citrate and Pb bound to humate were the organic species identified. The results of this study demonstrate the ability of XAFS to identify Pb speciation in house dust and show the potential to identify Pb sources from new homes versus older homes. Understanding Pb speciation and how it influences bioaccessibility is important for human health risk assessment and risk management decisions which aim to improve indoor environmental health. PMID:21591711

  3. Indoor Pollutant Hexabromocyclododecane Has a Modest Immunomodulatory Effect on House Dust Mite Induced Allergic Asthma in Mice.

    Science.gov (United States)

    Canbaz, Derya; Logiantara, Adrian; Hamers, Timo; van Ree, Ronald; van Rijt, Leonie S

    2016-01-01

    Hexabromocyclododecane (HBCD) has been recognized as an indoor pollutant. HBCD is added as a flame retardant to many consumer products and leaches from the products into house dust. HBCD might be potentially hazardous to the airways because of inhalation of house dust. Sensitization to house dust mite (HDM) is a risk factor for the development of allergic asthma. In this study, we examined whether HBCD can affect the immune response to HDM allergens. Bone-marrow-derived dendritic cells (BMDCs) were exposed simultaneously to HBCD and HDM in vitro. HBCD enhanced oxidative stress in HDM-pulsed BMDCs, which was accompanied by a higher production of Interleukin (IL)-6 and -10. Adoptive transfer of HDM/HBCD-exposed BMDCs into naı̈ve mice resulted in enhanced levels of IL-17A after inhalational challenge with HDM. Direct mucosal exposure to HBCD during HDM inhalation enhanced IL-4 or IL-17A production, depending on the HDM extract used, but did not aggravate the eosinophilic airway inflammation or airway hyper-reactivity. Our results indicate that exposure to HBCD can have a mild immune-modulating effect by enhancing the inflammatory cytokine production in response to inhaled HDM in mice. PMID:26633745

  4. Housing the "Other" Half: American Studies' Global Urban Turn

    Directory of Open Access Journals (Sweden)

    David Faflik

    2010-03-01

    Full Text Available

    Over the course of its short lifetime, the discipline of American studies has utilized a series of self-defining metaphors. With each successive paradigm shift in the field, each of these disciplinary figures, in turn, has been found wanting, and so replaced. American studies’ current, if not consensual, metaphor—the “border”—resembles not a few of its predecessors in that it is spatial in nature and effectively doubles as a figuration of the greater nation. The premise of this paper is that the “border,” like the figures that came before it, has outlived its serviceable purpose for a discipline that continues to evolve.

    This essay proposes the global city, or, more accurately, the global slum, as a post-“border” metaphor peculiarly adapted to the principled transnationalism that now defines American studies for many subscribing students and professionals. On the one hand, the urban has become a prevailing demographic fact in this, the new century. Thus, the multiethnic, multinational world metropolis recommends itself as a more-than-metaphor for the dynamic cultural contact that typifies ascendant hemispheric conceptions of the Americas. On the other hand, the figure of the peripheral city similarly, and spatially, evokes the majority “center” and minority “margin” model of American studies that critics would claim inhibits total global integration among the discipline’s geoculturally diverse practitioners, many of whom reside outside the continental United States. This essay conceptually deploys the world city to explore beyond these professional/territorial “borders.” Its three condensed case studies—first, of Gilded Age Manhattan, second, of the modern Turkish metropolis, and third, of a reunified Germany’s ethnic ghetto—constitute a brisk figurative exercise in “marginal” urban migration, wherein resides an alternate model, and metaphor, of American studies praxis today.

  5. Housing the "Other" Half: American Studies' Global Urban Turn

    Directory of Open Access Journals (Sweden)

    David Faflik

    2010-03-01

    Full Text Available Over the course of its short lifetime, the discipline of American studies has utilized a series of self-defining metaphors. With each successive paradigm shift in the field, each of these disciplinary figures, in turn, has been found wanting, and so replaced. American studies’ current, if not consensual, metaphor—the “border”—resembles not a few of its predecessors in that it is spatial in nature and effectively doubles as a figuration of the greater nation. The premise of this paper is that the “border,” like the figures that came before it, has outlived its serviceable purpose for a discipline that continues to evolve. This essay proposes the global city, or, more accurately, the global slum, as a post-“border” metaphor peculiarly adapted to the principled transnationalism that now defines American studies for many subscribing students and professionals. On the one hand, the urban has become a prevailing demographic fact in this, the new century. Thus, the multiethnic, multinational world metropolis recommends itself as a more-than-metaphor for the dynamic cultural contact that typifies ascendant hemispheric conceptions of the Americas. On the other hand, the figure of the peripheral city similarly, and spatially, evokes the majority “center” and minority “margin” model of American studies that critics would claim inhibits total global integration among the discipline’s geoculturally diverse practitioners, many of whom reside outside the continental United States. This essay conceptually deploys the world city to explore beyond these professional/territorial “borders.” Its three condensed case studies—first, of Gilded Age Manhattan, second, of the modern Turkish metropolis, and third, of a reunified Germany’s ethnic ghetto—constitute a brisk figurative exercise in “marginal” urban migration, wherein resides an alternate model, and metaphor, of American studies praxis today.

  6. 78 FR 54416 - Native American Housing Assistance and Self-Determination Act of 1996: Announcement of Negotiated...

    Science.gov (United States)

    2013-09-04

    ...) changed the way that housing assistance is provided to Native Americans. NAHASDA eliminated several... URBAN DEVELOPMENT 24 CFR Chapter IX Native American Housing Assistance and Self-Determination Act of... FR 35178), HUD announced in the Federal Register the list of proposed members for the...

  7. Primary nasal epithelium exposed to house dust mite extract shows activated expression in allergic individuals.

    Science.gov (United States)

    Vroling, Aram B; Jonker, Martijs J; Luiten, Silvia; Breit, Timo M; Fokkens, Wytske J; van Drunen, Cornelis M

    2008-03-01

    Nasal epithelial cells form the outermost protective layer against environmental factors. However, this defense is not just physical; it has been shown that epithelial cells respond by the production of inflammatory mediators that may affect local immune responses. In this research we set out to characterize potential differences between the responses of nasal epithelium from healthy and allergic individuals to house dust mite (HDM) allergen. These differences will help us to define local mechanisms that could contribute to allergic disease expression. Epithelial cells were cultured from nasal biopsies taken from five healthy and five allergic individuals. These cultures were exposed for 24 hours to culture medium containing HDM allergen, or to culture medium alone. Isolated RNA was used for microarray analysis. Gene-ontology of the response in healthy epithelium revealed mainly up-regulation of chemokines, growth factors, and structural proteins. Moreover, we saw increased expression of two transcription factors (NF-kappaB and AP-1) and their regulatory members. The expression pattern of epithelium from allergic individuals in the absence of the HDM stimulus suggests that it is already in an activated state. Most striking is that, while the already activated NF-kappaB regulatory pathway remained unchanged in allergic epithelium, the AP-1 pathway is down-regulated upon exposure to HDM allergen; this is contrary to what we see in healthy epithelium. Clear differences in the expression pattern exist between epithelial cells isolated from healthy and allergic individuals at baseline and between their responses to allergen exposure; these differences may contribute to the inflammatory response. PMID:17901406

  8. Airborne dust, ammonia, microorganisms, and antigens in pig confinement houses and the respiratory health of exposed farm workers.

    Science.gov (United States)

    Crook, B; Robertson, J F; Glass, S A; Botheroyd, E M; Lacey, J; Topping, M D

    1991-07-01

    This study investigated the environmental conditions on pig farms and the respiratory health of pig farmers and their immunological response to airborne contaminants. Airborne concentrations of dust and ammonia were measured in 20 pig houses; viable microorganisms, endotoxins, and aeroallergens were measured in 6 of these houses, chosen to represent the range in dustiness. The 29 farmers employed on the farms completed a questionnaire and underwent lung function tests; 24 of them provided blood samples for the measurement of specific IgE and IgG antibody to extracts of pig squames and urine, feed components, and bacterial isolates. Mean airborne dust and ammonia concentrations in the pig houses ranged from 1.66 to 21.04 mg/m3 and from 1.50 to 13.23 ppm, respectively. Factors affecting these concentrations include time of year, feed systems used, and levels of ventilation. There was no direct relationship between airborne dust and ammonia concentrations. Airborne microorganisms ranged from 10(5) to more than 10(7) colony-forming units (cfu)/m3; most were bacteria, with few fungi or thermophilic actinomycetes isolated. Gram-positive bacterial genera (Staphylococcus, Micrococcus, and Bacillus spp.) predominated. Concentrations of endotoxin in collected airborne dust were low. Work-related respiratory symptoms, typically chest tightness/wheeze and nasal and eye irritation, were reported by 23 of the 29 workers. Three farmers had specific IgE to pig squames or urine and eight to feed components but none to the microbial extracts. Specific IgG to pig squames or urine and to feed components was demonstrated in 14 and 9 workers, respectively. Specific IgE responses occurred mainly in subjects with chest tightness or wheeze, although specific IgG responses were not related to symptoms.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1951065

  9. Home dampness, fungi and house dust mites, and respiratory symptoms in children

    OpenAIRE

    Verhoeff, Arnoud Paul

    1994-01-01

    textabstractDamp houses are common in the Netherlands. A study conducted in 1985 at the request of the Ministry of Housing, Physical Planning and Environment, among housing corporations that managed 1.6 million houses (almost one third of the total housing stock in the Netherlands at that time) showed that approximately 18% of these houses were affected by dampness to at least some degree (Tannnes et aI. 1985). More recently, the prevalence of home dampness in the Netherlands was investigated...

  10. Gentrification in black and white: the racial impact of public housing demolition in American cities.

    Science.gov (United States)

    Goetz, Edward

    2011-01-01

    The gentrification that has transformed high-poverty neighbourhoods in US cities since the mid 1990s has been characterised by high levels of state reinvestment. Prominent among public-sector interventions has been the demolition of public housing and in some cases multimillion dollar redevelopment efforts. In this paper, the racial dimension of state-supported gentrification in large US cities is examined by looking at the direct and indirect displacement induced by public housing transformation. The data show a clear tendency towards the demolition of public housing projects with disproportionately high African American occupancy. The pattern of indirect displacement is more varied; public housing transformation has produced a number of paths of neighbourhood change. The most common, however, involve significant reductions in poverty, sometimes associated with Black to White racial turnover and sometimes not. The findings underscore the central importance of race in understanding the dynamics of gentrification in US cities. PMID:21949948

  11. Using paired soil and house dust samples in an in vitro assay to assess the post ingestion bioaccessibility of sorbed fipronil.

    Science.gov (United States)

    Starr, James M; Li, Weiwei; Graham, Stephen E; Bradham, Karen D; Stout Ii, Daniel M; Williams, Alan; Sylva, Jason

    2016-07-15

    For children, ingestion of soils and house dusts can be an important exposure pathway for regulated organic compounds. Following ingestion, the extent to which compounds desorb and become bioaccessible is a critical determinant of systemic adsorption. We characterized the physicochemical properties of 37 soil and house dust pairs collected during a national survey of United States homes. For each sample, we measured the bioaccessibility of fipronil, a phenylpyrazole insecticide using an in vitro, three- compartment digestive system, then modeled the physicochemical predictors of fipronil bioaccessibility. The properties of the soils and dusts were not correlated and percent carbon was the only significant predictor of bioaccessibility for both soils (psoils (3.1±2.4%) was lower than that of the dusts (18.6±6.9%) Due to the lower carbon content, soil sorbed fipronil was more bioaccessible than dust sorbed fipronil. However, the slope of the bioaccessibility carbon regression line was steeper for the soils than for the house dusts. This suggested that, for soils having carbon percentages greater than those in this study, fipronil bioaccessibility may be less than that of house dusts having equal carbon content. PMID:27017400

  12. The use of isotope ratios to apportion sources of lead in Jersey City, NJ, house dust wipe samples

    International Nuclear Information System (INIS)

    Lead stable isotope ratio (IR) analysis by inductively coupled plasma mass spectrometry was used to examine the relationship between sources of Pb in 22 dust wipe samples collected from 10 homes in Jersey City, NJ. Common lead sources examined included interior lead-based paints, exterior soils and street dusts, and indoor air. High correlations between IRs of wipe samples and both street dusts and exterior soils indicated these two exterior sources were indistinguishable. They were treated as a single exterior source in a source apportionment using IR matching and a simple mixing model. The upper-bound estimate of the contribution of interior lead-based paints to 10 floor- and eight sill-wipe samples was 56% and 50%, respectively. It was not possible to apportion sources in four of the 22 samples because wipe sample IRs were outside the range of measured sources. Examination of means obscures the variability in the data, however, as eight of the 18 apportioned samples matched interior or exterior source media. In most cases, however, sources from outside the home contribute as much Pb to house dust wipe samples as interior lead-based paints. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  13. Effect of house dust mite immunotherapy on interleukin-10-secreting regulatory T cells in asthmatic children

    Institute of Scientific and Technical Information of China (English)

    WANG Wei; XIANG Li; LIU Yong-ge; WANG Yong-hong; SHEN Kun-ling

    2010-01-01

    Background Subcutaneous specific immunotherapy has been demonstrated to be capable of inducing T-cell regulatory response.Interleukin-10 (IL-10) plays a crucial role in inducing allergen-specific tolerance.However the reports of the changes of IL-10 in house dust mite (HDM)-specific immunotherapy were varied.The aim of this study was to evaluate the function of IL-10-secreting regulatory T cells in asthma children successfully treated with HDM immunotherapy.Methods Peripheral blood mononuclear cells (PBMCs) were isolated from 27 patients following 1.5--2 years of HDM-specific immunotherapy (SIT, SIT group) and from 27 matched treated asthmatic children allergic to HDM (asthmagroup).After 48 hours of in vitro stimulation with HDM extracts, IL-10-secreting regulatory T cells were measured by four colour flow cytometry.Sera were tested for allergen-specific IgG4 and IgE using the Immuno CAP 100 assay.Results PBMCs from children undergoing immunotherapy following HDM extracts stimuli produced significantly more IL-10 compared with the asthma group.The frequency of iTreg cells and aTreg cells increased in SIT group after HDM stimulation, while it was not affected in the asthma group.Among the iTreg cells and aTreg cells, the frequency of CD4+CD25-Foxp3-IL-10+ Treg cells increased the most which was 2 times higher than that in unstimulated cultures in SIT group.The levels of HDM-specific IgG4 of SIT group was significiently higher compared with asthma group, but there was no correlation of the levels of HDM-specific IgG4 and IL-10 secreting Treg cells.Conclusions HDM-specific immunotherapy can successfully upregulate the frequency of IL-10-secreting Treg cells.CD4+CD25-Foxp3-IL-10+ Treg cells may play a key role in inducing the immune tolerance in HDM-specific immunotherapy.

  14. Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma

    Directory of Open Access Journals (Sweden)

    Hadeesha Piyadasa

    2016-02-01

    Full Text Available House dust mite (HDM challenge is commonly used in murine models of allergic asthma for preclinical pathophysiological studies. However, few studies define objective readouts or biomarkers in this model. In this study we characterized immune responses and defined molecular markers that are specifically altered after HDM challenge. In this murine model, we used repeated HDM challenge for two weeks which induced hallmarks of allergic asthma seen in humans, including airway hyper-responsiveness (AHR and elevated levels of circulating total and HDM-specific IgE and IgG1. Kinetic studies showed that at least 24 h after last HDM challenge results in significant AHR along with eosinophil infiltration in the lungs. Histologic assessment of lung revealed increased epithelial thickness and goblet cell hyperplasia, in the absence of airway wall collagen deposition, suggesting ongoing tissue repair concomitant with acute allergic lung inflammation. Thus, this model may be suitable to delineate airway inflammation processes that precede airway remodeling and development of fixed airway obstruction. We observed that a panel of cytokines e.g. IFN-γ, IL-1β, IL-4, IL-5, IL-6, KC, TNF-α, IL-13, IL-33, MDC and TARC were elevated in lung tissue and bronchoalveolar fluid, indicating local lung inflammation. However, levels of these cytokines remained unchanged in serum, reflecting lack of systemic inflammation in this model. Based on these findings, we further monitored the expression of 84 selected genes in lung tissues by quantitative real-time PCR array, and identified 31 mRNAs that were significantly up-regulated in lung tissue from HDM-challenged mice. These included genes associated with human asthma (e.g. clca3, ear11, il-13, il-13ra2, il-10, il-21, arg1 and chia1 and leukocyte recruitment in the lungs (e.g. ccl11, ccl12 and ccl24. This study describes a biosignature to enable broad and systematic interrogation of molecular mechanisms and intervention

  15. Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma.

    Science.gov (United States)

    Piyadasa, Hadeesha; Altieri, Anthony; Basu, Sujata; Schwartz, Jacquie; Halayko, Andrew J; Mookherjee, Neeloffer

    2016-01-01

    House dust mite (HDM) challenge is commonly used in murine models of allergic asthma for preclinical pathophysiological studies. However, few studies define objective readouts or biomarkers in this model. In this study we characterized immune responses and defined molecular markers that are specifically altered after HDM challenge. In this murine model, we used repeated HDM challenge for two weeks which induced hallmarks of allergic asthma seen in humans, including airway hyper-responsiveness (AHR) and elevated levels of circulating total and HDM-specific IgE and IgG1. Kinetic studies showed that at least 24 h after last HDM challenge results in significant AHR along with eosinophil infiltration in the lungs. Histologic assessment of lung revealed increased epithelial thickness and goblet cell hyperplasia, in the absence of airway wall collagen deposition, suggesting ongoing tissue repair concomitant with acute allergic lung inflammation. Thus, this model may be suitable to delineate airway inflammation processes that precede airway remodeling and development of fixed airway obstruction. We observed that a panel of cytokines e.g. IFN-γ, IL-1β, IL-4, IL-5, IL-6, KC, TNF-α, IL-13, IL-33, MDC and TARC were elevated in lung tissue and bronchoalveolar fluid, indicating local lung inflammation. However, levels of these cytokines remained unchanged in serum, reflecting lack of systemic inflammation in this model. Based on these findings, we further monitored the expression of 84 selected genes in lung tissues by quantitative real-time PCR array, and identified 31 mRNAs that were significantly up-regulated in lung tissue from HDM-challenged mice. These included genes associated with human asthma (e.g. clca3, ear11, il-13, il-13ra2, il-10, il-21, arg1 and chia1) and leukocyte recruitment in the lungs (e.g. ccl11, ccl12 and ccl24). This study describes a biosignature to enable broad and systematic interrogation of molecular mechanisms and intervention strategies for

  16. Immune response to allergens in sheep sensitized to house dust mite

    Directory of Open Access Journals (Sweden)

    Velden Joanne

    2008-10-01

    Full Text Available Abstract Background House dust mite (HDM allergens are a major cause of allergic asthma. Most studies using animal models of allergic asthma have used rodents sensitized with the 'un-natural' allergen ovalbumin. It has only recently been recognized that the use of animal models based on HDM provide a more relevant insight into the allergen-induced mechanisms that underpin human allergic disease. We have previously described a sheep model of human allergic asthma that uses Dermatophagoides pteronyssinus HDM. The present study extends our understanding of the immune effects of HDM and the allergens Der p 1 and Der p 2 in the sheep model of asthma. Methods Peripheral blood sera from non-sensitized (control sheep and sheep sensitized to HDM was collected to determine immunoglobulin (Ig reactivities to HDM, Der p 1 and Der p 2 by ELISA. Bronchoalveolar lavage (BAL fluid collected following allergen challenge was also assessed for the presence of HDM-specific antibodies. To examine the cellular immune response to HDM allergens, T cell proliferation and cutaneous responses were assessed in sensitized and control sheep. Results Strong HDM- and Der p 1-specific IgE, IgG1, IgG2 and IgA serum responses were observed in sensitized sheep, while detectable levels of HDM-specific IgG1 and IgA were seen in BAL fluid of allergen-challenged lungs. In contrast, minimal antibody reactivity was observed to Der p 2. Marked T cell proliferation and late phase cutaneous responses, accompanied by the recruitment of eosinophils, indicates the induction of a cellular and delayed-type hypersensitivity (DTH type II response by HDM and Der p 1 allergen, but not Der p 2. Conclusion This work characterizes the humoral and cellular immune effects of HDM extract and its major constituent allergens in sheep sensitized to HDM. The effects of allergen in HDM-sensitized sheep were detectable both locally and systemically, and probably mediated via enzymatic and immune actions of the

  17. Spatiotemporal analysis and human exposure assessment on polycyclic aromatic hydrocarbons in indoor air, settled house dust, and diet: A review.

    Science.gov (United States)

    Ma, Yuning; Harrad, Stuart

    2015-11-01

    This review summarizes the published literature on the presence of polycyclic aromatic hydrocarbons (PAH) in indoor air, settled house dust, and food, and highlights geographical and temporal trends in indoor PAH contamination. In both indoor air and dust, ΣPAH concentrations in North America have decreased over the past 30 years with a halving time of 6.7±1.9years in indoor air and 5.0±2.3 years in indoor dust. In contrast, indoor PAH concentrations in Asia have remained steady. Concentrations of ΣPAH in indoor air are significantly (pAmerica. In studies recording both vapor and particulate phases, the global average concentration in indoor air of ΣPAH excluding naphthalene is between 7 and 14,300 ng/m(3). Over a similar period, the average ΣPAH concentration in house dust ranges between 127 to 115,817ng/g. Indoor/outdoor ratios of atmospheric concentrations of ΣPAH have declined globally with a half-life of 6.3±2.3 years. While indoor/outdoor ratios for benzo[a]pyrene toxicity equivalents (BaPeq) declined in North America with a half-life of 12.2±3.2 years, no significant decline was observed when data from all regions were considered. Comparison of the global database, revealed that I/O ratios for ΣPAH (average=4.3±1.3), exceeded significantly those of BaPeq (average=1.7±0.4) in the same samples. The significant decline in global I/O ratios suggests that indoor sources of PAH have been controlled more effectively than outdoor sources. Moreover, the significantly higher I/O ratios for ΣPAH compared to BaPeq, imply that indoor sources of PAH emit proportionally more of the less carcinogenic PAH than outdoor sources. Dietary exposure to PAH ranges from 137 to 55,000 ng/day. Definitive spatiotemporal trends in dietary exposure were precluded due to relatively small number of relevant studies. However, although reported in only one study, PAH concentrations in Chinese diets exceeded those in diet from other parts of the world, a pattern consistent with

  18. Concentrations of Surface-Dust Metals in Native American Jewelry-Making Homes in Zuni Pueblo, New Mexico

    OpenAIRE

    Gonzales, Melissa; Shah, Vallabh; Bobelu, Arlene; QUALLS, Clifford; Natachu, Kathy; Bobelu, Jeanette; Jamon, Eunice; Neha, Donica; Paine, Susan; Zager, Philip

    2004-01-01

    This pilot study was conducted to identify the metals used by home-based Native American jewelry makers, to quantify the metals in dust samples taken from jewelers’ homes, and to compare these concentrations with background levels from control homes in which jewelry was not made. Participants were recruited from Zuni Pueblo, New Mexico. Surface dust samples were collected from the work and living areas of 20 jewelers’ homes, and from the living areas of 20 control homes. Silver, copper, tin, ...

  19. Housing and neighborhood quality among undocumented Mexican and Central American immigrants.

    Science.gov (United States)

    Hall, Matthew; Greenman, Emily

    2013-11-01

    Extensive research has documented the challenges that undocumented immigrants face in navigating U.S. labor markets, but relatively little has explored the impact of legal status on residential outcomes despite their widespread repercussions for social well-being. Using data from the 1996-2008 panels of the Survey of Income and Program Participation to impute documentation status among Mexican and Central American immigrants, we examine group differences in residential outcomes, including homeownership, housing crowding, satisfaction with neighborhood and housing quality, problems with neighborhood crime/safety, governmental services, and environmental issues, and deficiencies with housing units. Results from our analysis indicate that undocumented householders are far less likely to be homeowners than documented migrants, and also live in more crowded homes, report greater structural deficiencies with their dwellings, and express greater concern about the quality of public services and environmental conditions in their neighborhoods. In comparison to native whites, undocumented migrants' residential circumstances are lacking, but their residential outcomes tend to be superior to those of native-born blacks. Overall, our results highlight the pervasive impact of legal status on stratifying Mexicans' and Central Americans' prospects for successful incorporation, but also underscore the rigidity of the black/nonblack divide structuring American residential contexts. PMID:24090862

  20. Modification of house dust mite allergens by monomethoxypolyethylene glycol. Allergenicity measured by in vitro and in vivo methods.

    Science.gov (United States)

    Mosbech, H; Dreborg, S; Påhlman, I; Stahl Skov, P; Steringer, I; Weeke, B

    1988-01-01

    In animal models, allergen modification by coupling to monomethoxypolyethylene glycol (mPEG) molecules can reduce allergenicity of the extract and makes the allergen capable of suppressing boosted IgE response. To investigate in a human system the degree of attenuation implied by a mPEG modification of a house dust mite (Dermatophagoides pteronyssinus) extract, 55 adults with asthma caused by house dust mites were tested by skin prick test (SPT) and histamine release assay (HR). RAST inhibition was performed on sera from 6 additional patients. Modified extract containing 0.42 mmol mPEG/g protein was used for the analyses. In order to get the same response of the two extracts when assessed by HR and SPT, a median increase in concentration of 10-fold of the mPEG-modified extract compared to the unmodified extract was needed. Interindividual variation was limited. Sixty-four to 72% needed a dose increase within +/- half a decade from this value. In 42-49% of the patients, results from SPT and HR deviated less than half a decade. The relative potency of the modified extract as measured by RAST inhibition was reduced to 17-78% (mean 39%). Reduced allergenicity would by itself mean less side effects in immunotherapy. When planning such therapy it is important to know that mPEG modification reduces the allergenicity to a similar extent in a majority of patients. PMID:2448247

  1. Studies on the Occurrence, Identification and Control of House Dust Mites at Rural Houses of Shebin El-Kom Locality, Egypt.

    Science.gov (United States)

    Heikal, H M

    2015-04-01

    The present study was conducted at Elkom Elakhdar village, Shebin El-Kom, Menoufia Governorate along 2012 year seasons, to calculate and identify the species composition and the occurrence frequency of the extracted dust mites collected from three building ages at rural houses, as well as to determine the toxicity limits of different concentrations of three plant essential oils against two species of the family Pyroglyphidae the main causal of allergy to humans. The obtained results revealed that there were eleven mite species belong to five families (Pyroglyphidae, Chortoglyphidae, Glycyphagidae, Acaridae and Cheyletidae). Of the total collected mites (5276) the highest dominant percentage species was the dust mites: Dermatophagoides farinae (66.1%), followed by D. pteronyssinus (23.3%), while the percentages of the rest species: Chortoglyphus arcuatus, Lepidoglyphus destructor, Glycyphagus domesticus, Gohieria fusca, Tyrophagusputrescentiae, Caloglyphus sp, Cheyletus malaccensis, Blomia sp. and Acarus siro were ranged between 0.16-2.0%. Regarding to the effect of temperature degrees on mite population, high degrees more than 25 degrees C at summer season, decreased the numbers of D. farinae and D. pteronyssinus. Toxicological tests of the three plant essential oils against adult stages of D. farinae and D. pteronyssinus showed that lemon grass oil gave the highest toxicity effect, in comparison with geranium and thyme oils, where mortality percentages were approximately around 100% at 800 ppm concentration on both species. The LC50 of lemon grass were 228.992 and 293.615 ppm against the two species, respectively. From the results of the research, it could be recommend that it is preferable to apply control operation during summer season where the mite population density is the least, moreover, the botanical oil extracts effectively controlled the parasitic dust mites, D. farinae and D. pteronyssinus and can be used in the biological control programs, as well as

  2. Risk assessment of non-dietary exposure to polycyclic aromatic hydrocarbons (PAHs) via house PM2.5, TSP and dust and the implications from human hair

    Science.gov (United States)

    Wang, Wei; Huang, Min-juan; Chan, Chuen-Yu; Cheung, Kwai Chung; Wong, Ming Hung

    2013-07-01

    To evaluate the cancer risk due to non-dietary PAHs exposure in home environment (inhalation and ingestion), exposure to fine particles (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) of PM2.5, total suspend particles (TSP) and dust in homes at two urban centers of Pearl River Delta were assessed. House PM2.5 bound PAHs in Guangzhou (GZ) ranged from 10.0 to 61.9 ng m-3 and 0.72 to 8.15 ng m-3 in Hong Kong (HK). PAH profiles found in PM2.5, TSP and dust were different than that in hair (dominated by Nap and Phe). Pyr and Flu in house dust significantly correlated with that in hair (r = 0.69; 0.55, p houses of GZ (10-5-10-4) were significantly higher than those of HK (10-6-10-5), which were also significantly higher than the cancer risks associated with house dust intake (10-7-10-5) in GZ. PAHs exposure via non-dietary route (PM2.5 and dust) was found to be 1-3 times higher than fish consumption for children and contributed to 52-76% of total PAHs intake for children and 24-50% for adults in GZ.

  3. A survey of abnormal repetitive behaviors in North American river otters housed in zoos.

    Science.gov (United States)

    Morabito, Paige; Bashaw, Meredith J

    2012-01-01

    Stereotypic behaviors, indicating poor welfare and studied in a variety of species (especially carnivores), appear related to characteristics of current and past environments. Although North American river otters (Lontra canadensis) often develop abnormal, repetitive, possibly stereotypic behaviors, no published reports describe otter housing and management or characterize how these variables relate to abnormal repetitive behavior (ARB) occurrence. The first author developed surveys to gather data on housing, individual history, management, and the prevalence of ARBs in otters housed in facilities accredited by the Association of Zoos and Aquariums. Consistent with anecdotal evidence that otters are prone to ARBs, 46% of river otters in the study exhibit them. ARBs were mostly locomotor and often preceded feeding. Exhibits where otters were fed and trained housed a greater percentage of nonhuman animals with ARBs. This study supports the Tarou, Bloomsmith, and Maple (2005) report that more hands-on management is associated with higher levels of ARBs because management efforts are only for animals with ARBs. Escape motivation, breeding season, feeding cues, and ability to forage may affect ARBs in river otters and should be investigated. PMID:22742198

  4. Determination of polybrominated diphenyl ethers in house dust using standard addition method and gas chromatography with electron capture and mass spectrometric detection.

    Science.gov (United States)

    Król, Sylwia; Zabiegała, Bożena; Namieśnik, Jacek

    2012-08-01

    Monitoring of the environmental fate of polybrominated diphenyl ethers (PBDEs) involves determination of their concentration in air, airborne particles and settled dust. This requires the implementation of appropriate analytical tools like measuring instruments, reference materials and analytical procedures. In this study an analytical procedure was developed for determining PBDEs in samples with a complex matrix composition. The efficiencies of three different extraction techniques - Soxhlet extraction (SE), Accelerated Solvent Extraction (ASE) and Ultrasound Assisted Extraction (UAE) - were compared. The study investigated the possibility of using the standard addition method for estimating PBDEs levels. The GC-μECD system was successfully applied as an alternative to low resolution mass spectrometry (LRMS) for determining BDE-209 in dust samples. The developed analytical procedure was then used to analyze dust samples, collected from houses and computer suites in the Tri-city area (Gdansk, Gdynia and Sopot), in order to detect and quantify the presence of polybrominated diphenyl ethers (PBDEs) in the indoor environment. Concentrations of studied congeners (from triBDE to heptaBDE), obtained by chromatographic analysis of dust samples extracts, performed applying two measurement systems (GC-EIMS and GC-μECD) ranged between 331 and 3102 ng g(-1) for house dust and between dust. The highest concentrations were obtained for congeners with four, five and six bromine atoms (BDE-47, BDE-99, BDE-100 and BDE-153). Concentrations of BDE-209 ranged from 384 ng g(-1) (house dust) to 12,553 ng g(-1) (electronic dust). PMID:22749362

  5. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet

    DEFF Research Database (Denmark)

    Demoly, Pascal; Emminger, Waltraud; Rehm, Dorte;

    2016-01-01

    BACKGROUND: The SQ HDM SLIT-tablet (ALK) has been developed for treatment of house dust mite (HDM)-induced respiratory allergic disease. OBJECTIVE: This trial investigated the efficacy and safety of the SQ HDM SLIT-tablet in adults with moderate-to-severe HDM-induced allergic rhinitis (AR). METHODS......: The trial was a randomized, double-blind, placebo-controlled phase III trial conducted in 12 European countries including 992 adults with moderate-to-severe HDM-induced AR despite treatment with pharmacotherapy. Subjects were randomized 1:1:1 to 1 year of daily treatment with placebo, 6 SQ-HDM, or 12...... SQ-HDM. The primary end point was the total combined rhinitis score (ie, the sum of rhinitis symptom and medication scores) during the efficacy assessment period (approximately the last 8 weeks of the treatment period). Key secondary end points were rhinitis symptoms, medication scores, quality of...

  6. Inhaled house dust programs pulmonary dendritic cells to promote type 2 T-cell responses by an indirect mechanism.

    Science.gov (United States)

    Moran, Timothy P; Nakano, Keiko; Whitehead, Gregory S; Thomas, Seddon Y; Cook, Donald N; Nakano, Hideki

    2015-11-15

    The induction of allergen-specific T helper 2 (Th2) cells by lung dendritic cells (DCs) is a critical step in allergic asthma development. Airway delivery of purified allergens or microbial products can promote Th2 priming by lung DCs, but how environmentally relevant quantities and combinations of these factors affect lung DC function is unclear. Here, we investigated the ability of house dust extract (HDE), which contains a mixture of environmental adjuvants, to prime Th2 responses against an innocuous inhaled antigen. Inhalational exposure to HDE conditioned lung conventional DCs, but not monocyte-derived DCs, to induce antigen-specific Th2 differentiation. Conditioning of DCs by HDE was independent of Toll-like receptor 4 signaling, indicating that environmental endotoxin is dispensable for programming DCs to induce Th2 responses. DCs directly treated with HDE underwent maturation but were poor stimulators of Th2 differentiation. In contrast, DCs treated with bronchoalveolar lavage fluid (BALF) from HDE-exposed mice induced robust Th2 differentiation. DC conditioning by BALF was independent of the proallergic cytokines IL-25, IL-33, and thymic stromal lymphopoietin. BALF treatment of DCs resulted in upregulation of CD80 but low expression of CD40, CD86, and IL-12p40, which was associated with Th2 induction. These findings support a model whereby environmental adjuvants in house dust indirectly program DCs to prime Th2 responses by triggering the release of endogenous soluble factor(s) by airway cells. Identifying these factors could lead to novel therapeutic targets for allergic asthma. PMID:26386119

  7. The effect of encasings on quality of life in adult house dust mite allergic patients with rhinitis, asthma and/or atopic dermatitis

    NARCIS (Netherlands)

    Terreehorst, [No Value; Duivenvoorden, HJ; Tempels-Pavlica, Z; Oosting, AJ; de Monchy, JGR; Bruijnzeel-Koomen, CAFM; van Wijk, R.

    2005-01-01

    Background: Environmental control has been put forward as an integral part of the management of house dust mite (HDM) allergy in sensitized patients. To validate this statement allergic disorders involved in HDM allergy - allergic asthma, rhinitis and atopic eczema/dermatitis syndrome (AEDS) - shoul

  8. Using paired soil and house dust samples in an in vitro assay to assess the post ingestion bioaccessibility of sorbed fipronil

    Science.gov (United States)

    For children, ingestion of soils and house dusts can be an important exposure pathway for regulated organic compounds. Following ingestion, the extent to which compounds desorb and become bioaccessible is a critical determinant of systemic adsorption.We characterized the physicoc...

  9. Regulatory T Cell Depletion Abolishes the Protective Effect of Dietary Galacto-Oligosaccharides on Eosinophilic Airway Inflammation in House Dust Mite-Induced Asthma in Mice

    NARCIS (Netherlands)

    Verheijden, Kim At; Braber, Saskia; Leusink-Muis, Thea; Thijssen, Suzan; Boon, Louis; Kraneveld, Aletta D; Garssen, Johan; Folkerts, Gert; Willemsen, Linette Em

    2016-01-01

    BACKGROUND: In a murine model for house dust mite (HDM)-induced asthma, dietary galacto-oligosaccharides have been shown to suppress allergic symptoms. Previously, CD25(+) regulatory T cells (Tregs) induced by nondigestible oligosaccharides were found to protect against allergy development. OBJECTIV

  10. The Architects’ Small House Service Bureau and the American Institute of Architects

    Directory of Open Access Journals (Sweden)

    Lisa M. Tucker

    2012-10-01

    Full Text Available A group of Minnesota architects created the ASHSB in 1914 to provide a solution for theshortage of middle class housing in the U.S. By 1919, the bureau had offices throughout the U.S. and received the endorsement of both the American Institute of Architects and the Department of Commerce. During this time, the members of the Bureau produced hundreds of plan sets and monthly bulletins to assist homeowners with their housing choices. The monthly magazine The Small Home, in conjunction with the published plan books--Your Future Home and How to Plan, Finance, and BuildYour Home--dispensed valuable information to potential homebuyers across the nation. To date, one master’s thesis (Lisa Schrenk, University of Virginia 1990 and an article (Thomas Harvey, 1991 have been written about the ASHSB. Neither one discussed the relationship of this group with the AIA, a keyendorsement agency.This research involved extensive archival research at the AIA. Records from the early 20th century were analyzed to determine the relationship between the AIA and the ASHSB in the early 20th century. This relationship provides insight into the current lack of architectural involvement in single-family house design today. The single most prevalent building type in the U.S. is the single-family house, yet architects are little involved in the design of most of them. Architects have the ability and training to create sustainable, affordable, and well-design single-family houses and yet they do not. This paper seeks to provide one explanation through the interpretation of the historic relationship of the AIA to the ASHSB.

  11. Too big to be noticed: cryptic invasion of Asian camel crickets in North American houses

    Directory of Open Access Journals (Sweden)

    Mary Jane Epps

    2014-09-01

    Full Text Available Despite the rapid expansion of the built environment, we know little about the biology of species living in human-constructed habitats. Camel crickets (Rhaphidophoridae are commonly observed in North American houses and include a range of native taxa as well as the Asian Diestrammena asynamora (Adelung, a species occasionally reported from houses though considered to be established only in greenhouses. We launched a continental-scale citizen science campaign to better understand the relative distributions and frequency of native and nonnative camel crickets in human homes across North America. Participants contributed survey data about the presence or absence of camel crickets in homes, as well as photographs and specimens of camel crickets allowing us to identify the major genera and/or species in and around houses. Together, these data offer insight into the geographical distribution of camel crickets as a presence in homes, as well as the relative frequency and distribution of native and nonnative camel crickets encountered in houses. In so doing, we show that the exotic Diestrammena asynamora not only has become a common presence in eastern houses, but is found in these environments far more frequently than native camel crickets. Supplemental pitfall trapping along transects in 10 urban yards in Raleigh, NC revealed that D. asynamora can be extremely abundant locally around some homes, with as many as 52 individuals collected from pitfalls in a single yard over two days of sampling. The number of D. asynamora individuals present in a trap was negatively correlated with the trap’s distance from a house, suggesting that these insects may be preferentially associated with houses but also are present outside. In addition, we report the establishment in the northeastern United States of a second exotic species, putatively Diestrammena japanica Blatchley, which was previously undocumented in the literature. Our results offer new insight into the

  12. Analysis of the dust emissions from a naturally ventilated turkey house using tracer gas method.

    Science.gov (United States)

    Mostafa, Ehab; Diekmann, Bernd; Buescher, Wolfgang; Schneider, Till

    2016-06-01

    Particulate matter (PM) emissions are becoming increasingly important in licensing procedures for the construction of new livestock houses or for the modernization of existing ones. Emission predictions require reliable data about emission rates. On this account, it is necessary to obtain information about the emission development and the relevant influencing factors in naturally ventilated turkey houses. The primary objective of the present research was to describe different aspects of PM emissions from a naturally ventilated turkey house. This includes the quantification of PM emissions and descriptions of the relevant influencing factors. Moreover, the tracer gas decay (TGD) method for ventilation rate estimation had to be used. To determine the emission mass flow from livestock buildings, it was necessary to measure the concentration of the target substance in the exhaust air and the airflow volume. The PM concentration measurements were carried out with a light scattering aerosol spectrometer in the exhaust air. The airflow volume was determined using the TGD method. To this purpose, tracer gas was injected into the supply air before the concentration decay was measured in the exhaust air of the building. The main influences on the PM concentration and the PM size distribution were shown to be animal activity and air volume flow. For the turkey barn, the PM emission factor averaged 0.027 g h(-1) animal(-1) over the entire year. If service times were to be included in the calculation, the emission factor 0.021 g h(-1) animal(-1), again averaged over the entire year, is well below the regulatory limit. PMID:27234512

  13. Levels of polybrominated diphenyl ethers in settled house dust from urban dwellings with resident preschool-aged children in Nanjing, China.

    Science.gov (United States)

    Wang, Bing-Ling; Pang, Shu-tao; Zhang, Xiao-ling; Li, Xi-ling; Sun, Yong-gang; Lu, Xiao-mei; Zhang, Qi

    2015-01-01

    We investigated the levels and possible determinants of polybrominated diphenyl ethers (PBDEs) in the settled house-dust (SHD) of urban dwellings with resident preschool-aged children in Nanjing, China. The possible neurodevelopmental effects of house-dust PBDEs were also explored. SHD was collected from 216 urban houses. Levels of 8 PBDEs were measured by gas chromatography-negative chemical ionization mass spectrometry. The Child Behavior Checklist and the Gesell Development Inventory were used to evaluate the child's development. BDE47, BDE99, BDE153, BDE18, and BDE209 were detected in the SHD of >90 % of houses, of which BDE209 predominated. Most PBDEs were found at significantly greater levels in indoor than in outdoor dust (P geometric mean concentration, BDE209 and total BDEs showed significant risks for depressed behavior problems and lower personal social developmental quotients (DQs); BDE99 and BDE153 indicated a risk for lower personal social DQs. In conclusion, PBDEs (especially BDE209) are ubiquitous in urban SHD in Nanjing residences. Natural ventilation and floor materials potentially influence PBDE levels in SHD. The potential adverse effect of postnatal exposure to PBDEs on the behavior and neurodevelopment of preschool-age children requires follow-up in larger studies. PMID:25034333

  14. Genetically engineered Lactococcus lactis protect against house dust mite allergy in a BALB/c mouse model.

    Directory of Open Access Journals (Sweden)

    Chunqing Ai

    Full Text Available Mucosal vaccine based on lactic acid bacteria is an attractive concept for the prevention and treatment of allergic diseases, but their mechanisms of action in vivo are poorly understood. Therefore, we sought to investigate how recombinant major dust mite allergen Der p2-expressing Lactococcus lactis as a mucosal vaccine induced the immune tolerance against house dust mite allergy in a mouse model.Three strains of recombinant L. lactis producing Der p2 in different cell components (extracellular, intracellular and cell wall were firstly constructed. Their prophylactic potential was evaluated in a Der p2-sensitised mouse model, and immunomodulation properties at the cellular level were determined by measuring cytokine production in vitro.Der p2 expressed in the different recombinant L. lactis strains was recognized by a polyclonal anti-Der p2 antibody. Oral treatment with the recombinant L. lactis prior sensitization significantly prevented the development of airway inflammation in the Der p2-sensitized mice, as determined by the attenuation of inflammatory cells infiltration in the lung tissues and decrease of Th2 cytokines IL-4 and IL-5 levels in bronchoalveolar lavage. In addition, the serum allergen-specific IgE levels were significantly reduced, and the levels of IL-4 in the spleen and mesenteric lymph nodes cell cultures were also markedly decreased upon allergen stimulation in the mice fed with the recombinant L. lactis strains. These protective effects correlated with a significant up-regulation of regulatory T cells in the mesenteric lymph nodes.Oral pretreatment with live recombinant L. lactis prevented the development of allergen-induced airway inflammation primarily by the induction of specific mucosal immune tolerance.

  15. Correlates of Cumulative Sexual Risk Behaviors among African American Youth Living in Public Housing.

    Science.gov (United States)

    Nebbitt, Von E; Voisin, Dexter

    2016-09-01

    African American youth and especially those who reside in public housing report high rates of sexually transmitted disease (STI) risk behaviors; however, too few studies have examined the correlates of cumulative sexual risk behaviors among this population. This study recruited 298 youth ages 11 to 21 and examined to what degree factors such as age, gender, self-efficacy, substance use, negative peer norms, and delinquency were correlated with cumulative sexual risk behaviors. Major findings indicated that gender, substance use, self-efficacy, and involvement with delinquent peer networks were independent correlates of cumulative sexual risk behaviors, with gender and self-efficacy being the strongest of these factors. Collectively, these findings suggest that gendered approaches to sexual risk reduction among this population are warranted with special content and attention focused on substance abuse risk reduction, improving self-efficacy and managing negative peer influences. PMID:27294733

  16. Evaluation of HEPA vacuum cleaning and dry steam cleaning in reducing levels of polycyclic aromatic hydrocarbons and house dust mite allergens in carpets.

    Science.gov (United States)

    Yu, Chang Ho; Yiin, Lih-Ming; Tina Fan, Zhi-Hua; Rhoads, George G

    2009-01-01

    Dry steam cleaning, which has gained recent attention as an effective method to reduce house dust mite (HDM) allergen concentration and loading in carpets, was evaluated in this study for its efficacy in lowering levels of polycyclic aromatic hydrocarbons (PAHs) as well as HDM allergens. Fifty urban homes with wall-to-wall carpets, mostly low-income and with known lead contamination, were studied in 2003 and 2004. Two carpet-cleaning interventions were compared: Repeated HEPA (High Efficiency Particulate Air filtered) vacuuming alone and repeated HEPA vacuuming supplemented with dry steam cleaning. Vacuum samples were collected to measure carpet loading of dust and contaminants immediately before and after cleaning. Paired comparisons were conducted to evaluate the effectiveness of the cleaning protocols in reducing the levels of PAHs and HDM allergens in carpets. The results indicated that both cleaning methods substantially reduced the loading of PAHs and HDM allergens as well as dust in carpets (p < 0.0001). The reductions in loading of dust (64.4%), PAHs (69.1%), and HDM allergens (85.5%), by dry steam cleaning plus repetitive HEPA vacuuming were larger than the reductions by regular HEPA vacuuming alone: dust (55.5%), PAHs (58.6%), and HDM allergens (80.8%), although the difference was statistically significant only for dust and PAHs. We conclude that intensive HEPA vacuum cleaning substantially reduced the loading of PAHs and HDM allergens in carpets in these urban homes and that dry steam cleaning added modestly to cleaning effectiveness. PMID:19137159

  17. A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.

    Science.gov (United States)

    Llop-Guevara, Alba; Chu, Derek K; Walker, Tina D; Goncharova, Susanna; Fattouh, Ramzi; Silver, Jonathan S; Moore, Cheryl Lynn; Xie, Juliana L; O'Byrne, Paul M; Coyle, Anthony J; Kolbeck, Roland; Humbles, Alison A; Stämpfli, Martin R; Jordana, Manel

    2014-01-01

    Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b(+) DCs expressing OX40L. GM-CSF-driven allergic responses were significantly blunted in IL-33-deficient mice. IL-33 was localized on alveolar type II cells and in vitro stimulation of human epithelial cells with GM-CSF enhanced intracellular IL-33 independently of IL-1α. Likewise, GM-CSF administration in vivo resulted in increased levels of IL-33 but not IL-1α. These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway. PMID:24551140

  18. Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood.

    Science.gov (United States)

    Al-Garawi, A; Fattouh, R; Botelho, F; Walker, T D; Goncharova, S; Moore, C-L; Mori, M; Erjefalt, J S; Chu, D K; Humbles, A A; Kolbeck, R; Stampfli, M R; O'Byrne, P M; Coyle, A J; Jordana, M

    2011-11-01

    The origins of allergic asthma, particularly in infancy, remain obscure. Respiratory viral infections and allergen sensitization in early life have been associated with asthma in young children. However, a causal link has not been established. We investigated whether an influenza A infection in early life alters immune responses to house dust mite (HDM) and promotes an asthmatic phenotype later in life. Neonatal (8-day-old) mice were infected with influenza virus and 7 days later, exposed to HDM for 3 weeks. Unlike adults, neonatal mice exposed to HDM exhibited negligible immune responsiveness to HDM, but not to influenza A. HDM responsiveness in adults was associated with distinct Ly6c+ CD11b+ inflammatory dendritic cell and CD8α+ plasmacytoid (pDC) populations that were absent in HDM-exposed infant mice, suggesting an important role in HDM-mediated inflammation. Remarkably, HDM hyporesponsiveness was overcome when exposure occurred concurrently with an acute influenza infection; young mice now displayed robust allergen-specific immunity, allergic inflammation, and lung remodeling. Remodeling persisted into early adulthood, even after prolonged discontinuation of allergen exposure and was associated with marked impairment of lung function. Our data demonstrate that allergen exposure coincident with acute viral infection in early life subverts constitutive allergen hyporesponsiveness and imprints an asthmatic phenotype in adulthood. PMID:21881572

  19. A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.

    Directory of Open Access Journals (Sweden)

    Alba Llop-Guevara

    Full Text Available Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM, we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b(+ DCs expressing OX40L. GM-CSF-driven allergic responses were significantly blunted in IL-33-deficient mice. IL-33 was localized on alveolar type II cells and in vitro stimulation of human epithelial cells with GM-CSF enhanced intracellular IL-33 independently of IL-1α. Likewise, GM-CSF administration in vivo resulted in increased levels of IL-33 but not IL-1α. These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway.

  20. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice.

    Science.gov (United States)

    Li, Bobby W S; de Bruijn, Marjolein J W; Tindemans, Irma; Lukkes, Melanie; KleinJan, Alex; Hoogsteden, Henk C; Hendriks, Rudi W

    2016-06-01

    Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to study the induction of ILC2s in allergic airway inflammation. In BALF, lungs, and lymph nodes, ILC2 activation is critically dependent on prior sensitization with HDM. Importantly, T cells are required for ILC2 induction, whereby T-cell activation precedes ILC2 induction. During HDM-driven allergic airway inflammation the accumulation of ILC2s in BALF is IL-33 independent, although infiltrating ILC2s produce less cytokines in Il33(-/-) mice. Transfer of in vitro polarized OVA-specific OT-II Th2 cells alone or in combination with Th17 cells followed by OVA and HDM challenge is not sufficient to induce ILC2, despite significant eosinophilic inflammation and T-cell activation. In this asthma model, ILC2s are therefore not an early source of Th2 cytokines, but rather contribute to type 2 inflammation in which Th2 cells play a key role. Taken together, ILC2 induction in HDM-mediated allergic airway inflammation in mice critically depends on activation of T cells. PMID:27062360

  1. Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

    Science.gov (United States)

    Banerjee, Srinita; Resch, Yvonne; Chen, Kuan-Wei; Swoboda, Ines; Focke-Tejkl, Margit; Blatt, Katharina; Novak, Natalija; Wickman, Magnus; van Hage, Marianne; Ferrara, Rosetta; Mari, Adriano; Purohit, Ashok; Pauli, Gabrielle; Sibanda, Elopy N; Ndlovu, Portia; Thomas, Wayne R; Krzyzanek, Vladislav; Tacke, Sebastian; Malkus, Ursula; Valent, Peter; Valenta, Rudolf; Vrtala, Susanne

    2015-01-01

    House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test-based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD. PMID:24999597

  2. Allergic Responses Induced by a Fungal Biopesticide Metarhizium anisopliae and House Dust Mite Are Compared in a Mouse Model.

    Science.gov (United States)

    Ward, Marsha D W; Chung, Yong Joo; Copeland, Lisa B; Doerfler, Donald L

    2011-01-01

    Biopesticides can be effective in controlling their target pest. However, research regarding allergenicity and asthma development is limited. We compared the ability of fungal biopesticide Metarhizium anisopliae (MACA) and house dust mite (HDM) extracts to induce allergic responses in BALB/c mice. The extracts were administered by intratracheal aspiration at doubling doses (2.5-80 μg protein) 4X over a four-week period. Three days after the last exposure, serum and bronchoalveolar lavage fluid (BALF) were collected. The extracts' relative allergenicity was evaluated based on response robustness (lowest significant dose response compared to control (0 μg)). MACA induced a more robust serum total IgE response than HDM. However, in the antigen-specific IgE assay, a similar dose of both MACA and HDM was required to achieve the same response level. Our data suggest a threshold dose of MACA for allergy induction and that M. anisopliae may be similar to HDM in allergy induction potential. PMID:21785589

  3. Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice.

    Science.gov (United States)

    Ballester, Marie; Jeanbart, Laura; de Titta, Alexandre; Nembrini, Chiara; Marsland, Benjamin J; Hubbell, Jeffrey A; Swartz, Melody A

    2015-01-01

    An emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy requires further substantiation. We investigated the effect of pulmonary delivery of nanoparticle (NP)-conjugated CpG on lung immunity and found that NP-CpG led to enhanced recruitment of activated dendritic cells and to Th1 immunity compared to free CpG. We then evaluated if pulmonary delivery of NP-CpG could prevent and treat house dust mite-induced allergy by modulating immunity directly in lungs. When CpG was administered as immunomodulatory therapy prior to allergen sensitization, we found that NP-CpG significantly reduced eosinophilia, IgE levels, mucus production and Th2 cytokines, while free CpG had only a moderate effect on these parameters. In a therapeutic setting where CpG was administered after allergen sensitization, we found that although both free CpG and NP-CpG reduced eosinophilia and IgE levels to the same extent, NP conjugation of CpG significantly enhanced reduction of Th2 cytokines in lungs of allergic mice. Taken together, these data highlight benefits of NP conjugation and the relevance of NP-CpG as allergen-free therapy to modulate lung immunity and treat airway allergy. PMID:26387548

  4. Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood

    KAUST Repository

    Al-Garawi, A

    2011-08-31

    The origins of allergic asthma, particularly in infancy, remain obscure. Respiratory viral infections and allergen sensitization in early life have been associated with asthma in young children. However, a causal link has not been established. We investigated whether an influenza A infection in early life alters immune responses to house dust mite (HDM) and promotes an asthmatic phenotype later in life. Neonatal (8-day-old) mice were infected with influenza virus and 7 days later, exposed to HDM for 3 weeks. Unlike adults, neonatal mice exposed to HDM exhibited negligible immune responsiveness to HDM, but not to influenza A. HDM responsiveness in adults was associated with distinct Ly6c + CD11b + inflammatory dendritic cell and CD8α + plasmacytoid (pDC) populations that were absent in HDM-exposed infant mice, suggesting an important role in HDM-mediated inflammation. Remarkably, HDM hyporesponsiveness was overcome when exposure occurred concurrently with an acute influenza infection; young mice now displayed robust allergen-specific immunity, allergic inflammation, and lung remodeling. Remodeling persisted into early adulthood, even after prolonged discontinuation of allergen exposure and was associated with marked impairment of lung function. Our data demonstrate that allergen exposure coincident with acute viral infection in early life subverts constitutive allergen hyporesponsiveness and imprints an asthmatic phenotype in adulthood.

  5. The prevalence of allergic disease and IgE antibodies to house dust mite in schoolchildren in Taiwan.

    Science.gov (United States)

    Tang, R B; Tsai, L C; Hwang, H M; Hwang, B; Wu, K G; Hung, M W

    1990-01-01

    The prevalence of positive specific IgE antibodies to house dust mites (Dermatophagoides pteronyssinus; D. farinae) was determined by enzyme-linked immunosorbent assay (ELISA) in 5097 (61%) volunteers of 8345 schoolchildren aged between 7 and 14 yr from two government schools. All of them filled out a questionnaire concerning allergic symptoms. Among them, 412 (8.1%) children showed a positive reaction to at least one of the two mite allergens, the range varying between 5.6 and 11.2% according to the child's age. Boys had higher prevalence of positive mite specific IgE than girls (9.8% vs. 6.4%, P less than 0.01), with the overall male to female ratio 1.5:1. The prevalence of bronchial asthma in boys and girls was 5.3% and 3.3% respectively. The positive mite specific IgE antibody in children with asthma and allergic rhinitis was 52% (103 of 198) and 28.7% (193 of 673) respectively. The mean levels of mite specific IgE were not significantly related to the age of onset and severity of asthmatic symptoms (P greater than 0.1), but were significantly different among subjects with current and past asthma (P less than 0.001). It is suggested that the mite-specific IgE may play a role in the pathogenesis of bronchial asthma in children. PMID:2310980

  6. Associations of allergic sensitization and clinical phenotypes with innate immune response genes polymorphisms are modified by house dust mite allergen exposure

    OpenAIRE

    Kurowski, Marcin; Majkowska-Wojciechowska, Barbara; Wardzyńska, Aleksandra; Kowalski, Marek L

    2011-01-01

    Introduction Polymorphisms within innate immunity genes are associated with allergic phenotypes but results are variable. These associations were not analyzed with respect to allergen exposure. We investigated associations of TLR and CD14 polymorphisms with allergy phenotypes in the context of house dust mite (HDM) exposure. Material and methods Children, aged 12-16 years (n=326), were recruited from downtown and rural locations and assessed by allergist. Skin prick tests, total and HDM-speci...

  7. Phthalate concentrations in house dust in relation to autism spectrum disorder and developmental delay in the CHildhood Autism Risks from Genetics and the Environment (CHARGE) study

    OpenAIRE

    Philippat, Claire; Bennett, Deborah H.; Krakowiak, Paula; Rose, Melissa; Hwang, Hyun-Min; Hertz-Picciotto, Irva

    2015-01-01

    Background Phthalates are endocrine-disrupting chemicals that influence thyroid hormones and sex steroids, both critical for brain development. Aim We studied phthalate concentrations in house dust in relation to the risks of developing autism spectrum disorder (ASD) or developmental delay (DD). Methods Participants were a subset of children from the CHARGE (CHildhood Autism Risks from Genetics and the Environment) case–control study. ASD and DD cases were identified through the California De...

  8. Evaluation of HEPA vacuum cleaning and dry steam cleaning in reducing levels of polycyclic aromatic hydrocarbons and house dust mite allergens in carpets

    OpenAIRE

    Yu, Chang Ho; Yiin, Lih-Ming; Fan, Zhi-hua (Tina); Rhoads, George G.

    2008-01-01

    Dry steam cleaning, which has gained recent attention as an effective method to reduce house dust mite (HDM) allergen concentration and loading in carpets, was evaluated in this study for its efficacy in lowering levels of polycyclic aromatic hydrocarbons (PAHs) as well as HDM allergens. Fifty urban homes with wail-to-wall carpets, mostly low-income and with known lead contamination, were studied in 2003 and 2004. Two carpet-cleaning interventions were compared: Repeated HEPA (High Efficiency...

  9. Increased ventilation rate as way to reduce the exposure to house dust mites and improve the health of asthmatic children - an intervention design

    DEFF Research Database (Denmark)

    Spilak, Michal; Kolarik, Barbara; Gunnarsen, Lars

    2012-01-01

    both participants and paediatricians. Several physical and chemical parameters will be monitored including: air change rate, concentrations of different sizes of particles, air temperature, relative humidity, carbon dioxide concentration, number of house dust mites, and relevant allergens concentration......International field studies have documented that indoor air quality is unsatisfactory in many buildings. The overall hypothesis of this project is that improving the indoor environment in dwellings can improve health and reduce suffering from indoor related diseases such as allergy and asthma that...

  10. Block Copolymer/DNA Vaccination Induces a Strong Allergen-Specific Local Response in a Mouse Model of House Dust Mite Asthma

    OpenAIRE

    Rolland-Debord, Camille; Lair, David; Roussey-Bihouée, Tiphaine; Hassoun, Dorian; Evrard, Justine; Cheminant, Marie-Aude; Chesné, Julie; Braza, Faouzi; Mahay, Guillaume; Portero, Vincent; Sagan, Christine; Pitard, Bruno; Magnan, Antoine

    2014-01-01

    Background Allergic asthma is caused by abnormal immunoreactivity against allergens such as house dust mites among which Dermatophagoides farinae (Der f) is a common species. Currently, immunotherapy is based on allergen administration, which has variable effect from patient to patient and may cause serious side effects, principally the sustained risk of anaphylaxis. DNA vaccination is a promising approach by triggering a specific immune response with reduced allergenicity. Objective The aim ...

  11. Do Neighborhood Physical Activity Resources and Land Use Influence Physical Activity among African American Public Housing Residents?

    Science.gov (United States)

    Parker, Nathan H; O'Connor, Daniel P; Kao, Dennis T; Lee, Rebecca E

    2016-01-01

    Few studies have examined neighborhood influences on physical activity (PA) among low-income African Americans living in public housing. This study measured the associations of PA resources and land use with PA among 216 African Americans living in 12 low-income housing developments in Houston, Texas. Neighborhood measures included both detailed information from in-person audits and geographic information systems (GIS) data. Hierarchical linear regression models tested the associations of neighborhood PA resource availability and quality and land use density and diversity with individual-level, self-reported PA. Land use diversity was positively associated with walking among men after controlling for other neighborhood characteristics. Policies that promote land use diversity or improve the pedestrian environment in areas with diverse destinations may encourage PA among public housing residents. PMID:27524771

  12. Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma.

    Directory of Open Access Journals (Sweden)

    Okazaki,Morihiro

    1991-08-01

    Full Text Available Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001 and adults (r = 0.629, p less than 0.01. However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.

  13. Concentrations of surface-dust metals in Native American jewelry-making homes in Zuni Pueblo, New Mexico.

    Science.gov (United States)

    Gonzales, Melissa; Shah, Vallabh; Bobelu, Arlene; Qualls, Clifford; Natachu, Kathy; Bobelu, Jeanette; Jamon, Eunice; Neha, Donica; Paine, Susan; Zager, Philip

    2004-05-01

    This pilot study was conducted to identify the metals used by home-based Native American jewelry makers, to quantify the metals in dust samples taken from jewelers' homes, and to compare these concentrations with background levels from control homes in which jewelry was not made. Participants were recruited from Zuni Pueblo, New Mexico. Surface dust samples were collected from the work and living areas of 20 jewelers' homes, and from the living areas of 20 control homes. Silver, copper, tin, boron, nickel, zinc, lead, and cadmium were significantly higher in work areas than in living areas of jewelry-making homes (p < or = 0.02). Silver, copper, nickel, and antimony were significantly higher in living areas of jewelers' homes compared with control homes (p < or = 0.04). Ventilation measures did not effectively reduce metal concentrations in jewelers' homes; concentrations in nonwork areas remained elevated. PMID:16201670

  14. Acute, but not resolved, influenza A infection enhances susceptibility to house dust mite-induced allergic disease.

    Science.gov (United States)

    Al-Garawi, Amal A; Fattouh, Ramzi; Walker, Tina D; Jamula, Erin B; Botelho, Fernando; Goncharova, Susanna; Reed, Jennifer; Stampfli, Martin R; O'Byrne, Paul M; Coyle, Anthony J; Jordana, Manel

    2009-03-01

    The impact of respiratory viral infections on the emergence of the asthmatic phenotype is a subject of intense investigation. Most experimental studies addressing this issue have used the inert Ag OVA with controversial results. We examined the consequences of exposure to a low dose of the common aeroallergen house dust mite (HDM) during the course of an influenza A infection. First, we delineated the kinetics of the immune-inflammatory response in the lung of mice following intranasal infection with influenza A/PR8/34. Our data demonstrate a peak response during the first 10 days, with considerable albeit not complete resolution at day 39 postinfection (p.i.). At day 7 p.i., mice were exposed, intranasally, to HDM for 10 consecutive days. We observed significantly enhanced eosinophilic inflammation, an expansion in Th2 cells, enhanced HDM-specific IgE and IgG1 responses and increased mucous production. Furthermore, lung mononuclear cells produced enhanced IFN-gamma and IL-5, unchanged IL-13, and reduced IL-4. These immunologic and structural changes lead to marked lung dysfunction. This allergic phenotype occurs at a time when there is a preferential increase in plasmacytoid dendritic cells over myeloid dendritic cells, activated CD8(+) T cells, and increased IFN-gamma production, all of which have been proposed to inhibit allergic responses. In contrast, the inflammatory response elicited by HDM was reduced when exposure occurred during the resolution phase (day 40 p.i.). Interestingly, this was not associated with a reduction in sensitization. Thus, the proinflammatory environment established during an acute influenza A infection enhances Th2-polarized immunity to a low dose of HDM and precipitates marked lung dysfunction. PMID:19234206

  15. Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism.

    Science.gov (United States)

    Cates, Elizabeth C; Fattouh, Ramzi; Wattie, Jennifer; Inman, Mark D; Goncharova, Susanna; Coyle, Anthony J; Gutierrez-Ramos, José-Carlos; Jordana, Manel

    2004-11-15

    It is now well established that passive exposure to inhaled OVA leads to a state of immunological tolerance. Therefore, to elicit allergic sensitization, researchers have been compelled to devise alternative strategies, such as the systemic delivery of OVA in the context of powerful adjuvants, which are alien to the way humans are exposed and sensitized to allergens. The objectives of these studies were to investigate immune-inflammatory responses to intranasal delivery of a purified house dust mite (HDM) extract and to evaluate the role of GM-CSF in this process. HDM was delivered to BALB/c mice daily for 10 days. After the last exposure, mice were killed, bronchoalveolar lavage was performed, and samples were obtained. Expression/production of Th2-associated molecules in the lymph nodes, lung, and spleen were evaluated by real-time quantitative PCR and ELISA, respectively. Using this exposure protocol, exposure to HDM alone generated Th2 sensitization based on the expression/production of Th2 effector molecules and airway eosinophilic inflammation. Flow cytometric analysis demonstrated expansion and activation of APCs in the lung and an influx of activated Th2 effector cells. Moreover, this inflammation was accompanied by airways hyper-responsiveness and a robust memory-driven immune response. Finally, administration of anti-GM-CSF-neutralizing Abs markedly reduced immune-inflammatory responses in both lung and spleen. Thus, intranasal delivery of HDM results in Th2 sensitization and airway eosinophilic inflammation that appear to be mediated, at least in part, by endogenous GM-CSF production. PMID:15528378

  16. Neutralisation of interleukin-13 in mice prevents airway pathology caused by chronic exposure to house dust mite.

    Directory of Open Access Journals (Sweden)

    Kate L Tomlinson

    Full Text Available BACKGROUND: Repeated exposure to inhaled allergen can cause airway inflammation, remodeling and dysfunction that manifests as the symptoms of allergic asthma. We have investigated the role of the cytokine interleukin-13 (IL-13 in the generation and persistence of airway cellular inflammation, bronchial remodeling and deterioration in airway function in a model of allergic asthma caused by chronic exposure to the aeroallergen House Dust Mite (HDM. METHODOLOGY/PRINCIPAL FINDINGS: Mice were exposed to HDM via the intranasal route for 4 consecutive days per week for up to 8 consecutive weeks. Mice were treated either prophylactically or therapeutically with a potent neutralising anti-IL-13 monoclonal antibody (mAb administered subcutaneously (s.c.. Airway cellular inflammation was assessed by flow cytometry, peribronchial collagen deposition by histocytochemistry and airway hyperreactivity (AHR by invasive measurement of lung resistance (R(L and dynamic compliance (C(dyn. Both prophylactic and therapeutic treatment with an anti-IL-13 mAb significantly inhibited (P<0.05 the generation and maintenance of chronic HDM-induced airway cellular inflammation, peribronchial collagen deposition, epithelial goblet cell upregulation. AHR to inhaled methacholine was reversed by prophylactic but not therapeutic treatment with anti-IL-13 mAb. Both prophylactic and therapeutic treatment with anti-IL-13 mAb significantly reversed (P<0.05 the increase in baseline R(L and the decrease in baseline C(dyn caused by chronic exposure to inhaled HDM. CONCLUSIONS/SIGNIFICANCE: These data demonstrate that in a model of allergic lung disease driven by chronic exposure to a clinically relevant aeroallergen, IL-13 plays a significant role in the generation and persistence of airway inflammation, remodeling and dysfunction.

  17. Immunomodulation of airway epithelium cell activation by mesenchymal stromal cells ameliorates house dust mite-induced airway inflammation in mice.

    Science.gov (United States)

    Duong, Khang M; Arikkatt, Jaisy; Ullah, M Ashik; Lynch, Jason P; Zhang, Vivian; Atkinson, Kerry; Sly, Peter D; Phipps, Simon

    2015-11-01

    Allergic asthma is underpinned by T helper 2 (Th2) inflammation. Redundancy in Th2 cytokine function and production by innate and adaptive immune cells suggests that strategies aimed at immunomodulation may prove more beneficial. Hence, we sought to determine whether administration of mesenchymal stromal cells (MSCs) to house dust mite (HDM) (Dermatophagoides pteronyssinus)-sensitized mice would suppress the development of Th2 inflammation and airway hyperresponsiveness (AHR) after HDM challenge. We report that the intravenous administration of allogeneic donor MSCs 1 hour before allergen challenge significantly attenuated the features of allergic asthma, including tissue eosinophilia, Th2 cytokine (IL-5 and IL-13) levels in bronchoalveolar lavage fluid, and AHR. The number of infiltrating type 2 innate lymphoid cells was not affected by MSC transfer, suggesting that MSCs may modulate the adaptive arm of Th2 immunity. The effect of MSC administration was long lasting; all features of allergic airway disease were significantly suppressed in response to a second round of HDM challenge 4 weeks after MSC administration. Further, we observed that MSCs decreased the release of epithelial cell-derived alarmins IL-1α and high mobility group box-1 in an IL-1 receptor antagonist-dependent manner. This significantly decreased the expression of the pro-Th2 cytokine IL-25 and reduced the number of activated and antigen-acquiring CD11c(+)CD11b(+) dendritic cells in the lung and mediastinal lymph nodes. Our findings suggest that MSC administration can ameliorate allergic airway inflammation by blunting the amplification of epithelial-derived inflammatory cytokines induced by HDM exposure and may offer long-term protection against Th2-mediated allergic airway inflammation and AHR. PMID:25789608

  18. Asian dust storm influence on North American ambient PM levels: observational evidence and controlling factors

    Directory of Open Access Journals (Sweden)

    T. L. Zhao

    2008-05-01

    Full Text Available New observational evidence of the trans-Pacific transport of Asian dust and its contribution to the ambient particulate matter (PM levels in North America was revealed, based on the interannual variations between Asian dust storms and the ambient PM levels in western North America from year 2000 to 2006. A high correlation was found between them with an R2 value of 0.83. From analysis of the differences in the correlation between 2005 and 2006, three factors explain the variation of trans-Pacific transport and influences of Asian dust storms on PM levels in western North America. These were identified by modeling results and the re-analysis data. They were 1 Strength of frontal cyclones from Mongolia to north eastern China: The frontal cyclones in East Asia not only bring strong cold air outbreaks, generating dust storms in East Asia, but also lift Asian dust into westerly winds of the free troposphere for trans-Pacific transport; 2 Pattern of transport pathway over the North Pacific: The circulation patterns of westerlies over the North Pacific govern the trans-Pacific transport pattern. Strong zonal airflow of the westerly jet in the free troposphere over the North Pacific favor significant trans-Pacific transport of Asian dust; 3 Variation of precipitation in the North Pacific: The scavenging of Asian dust particles by precipitation is a major process of dust removal on the trans-Pacific transport pathway. Therefore, variation of precipitation in the North Pacific could affect trans-Pacific transport of Asian dust.

  19. Asian dust storm influence on North American ambient PM levels: observational evidence and controlling factors

    Directory of Open Access Journals (Sweden)

    T. L. Zhao

    2007-07-01

    Full Text Available New observational evidence of the trans-Pacific transport of Asian dust and its contribution to the ambient particulate matter (PM levels in North America was revealed, based on the interannual variations between Asian dust storms and the ambient PM levels in western North America from year 2000 to 2006. A high correlation was found between them with an R2 value of 0.83. From analysis of the differences in the correlation between 2005 and 2006, three factors explain the variation of trans-Pacific transport and influences of Asian dust storms on PM levels in western North America. These were identified by modeling results and the re-analysis data. They were 1 Strength of frontal cyclones from Mongolia to north eastern China: The frontal cyclones in East Asia not only bring strong cold air outbreaks, generating dust storms in East Asia, but also lift Asian dust into westerly winds of the free troposphere for trans-Pacific transport; 2 Pattern of transport pathway over the North Pacific: The circulation patterns of westerlies over the North Pacific govern the trans-Pacific transport pattern. Strong zonal airflow of the westerly jet in the free troposphere over the North Pacific favor significant trans-Pacific transport of Asian dust; 3 Variation of precipitation in the North Pacific: The scavenging of Asian dust particles by precipitation is a major process of dust removal on the trans-Pacific transport pathway; therefore, variation of precipitation in the North Pacific could affect trans-Pacific transport of Asian dust.

  20. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT: DUST SUPPRESSANT PRODUCTS: NORTH AMERICAN SALT COMPANY'S DUSTGARD

    Science.gov (United States)

    Dust suppressant products used to control particulate emissions from unpaved roads are among the technologies evaluated by the Air Pollution Control Technology (APCT) Verification Center, part of the U.S. Environmental Protection Agency's Environmental Technology Verification (ET...

  1. 78 FR 39539 - Establishing the White House Council on Native American Affairs

    Science.gov (United States)

    2013-07-01

    ... seeks to continue restoring and healing relations with Native Americans and to strengthen its... of life for Native Americans, and shall coordinate the United States Government's engagement with... important to Native Americans, including with tribal consortia, small businesses, education and...

  2. House Finch (Haemorhous mexicanus) Conjunctivitis, and Mycoplasma spp. Isolated from North American Wild Birds, 1994-2015.

    Science.gov (United States)

    Ley, David H; Hawley, Dana M; Geary, Steven J; Dhondt, André A

    2016-07-01

    Sampling wild birds for mycoplasma culture has been key to the study of House Finch (Haemorhous mexicanus) conjunctivitis, yielding isolates of Mycoplasma gallisepticum spanning the temporal and geographic ranges of disease from emergence to endemicity. Faced with the challenges and costs of sample collection over time and from remote locations for submission to our laboratory for mycoplasma culture, protocols evolved to achieve a practical optimum. Herein we report making M. gallisepticum isolates from House Finches almost every year since the disease emerged in 1994, and we now have 227 isolates from 17 states. Our wild bird host range for M. gallisepticum isolates includes Blue Jay ( Cyanocitta cristata ), American Goldfinch (Spinus tristis), Lesser Goldfinch (Spinus psaltria), Purple Finch (Haemorhous purpureus), Evening Grosbeak ( Coccothraustes vespertinus ), and herein first reports for Western Scrub-jay ( Aphelocoma californica ), and American Crow ( Corvus brachyrhynchos ). By collecting and identifying isolates from birds with clinical signs similar to those of House Finch conjunctivitis, we also expanded the known host range of Mycoplasma sturni and obtained isolates from additional wild bird species. Accumulating evidence shows that a diverse range of wild bird species may carry or have been exposed to M. gallisepticum in the US, as in Europe and Asia. Therefore, the emergence of a pathogenic M. gallisepticum strain in House Finches may actually be the exception that has allowed us to identify the broader epidemiologic picture. PMID:27285414

  3. Cost-minimization analysis of sublingual immunotherapy versus subcutaneous immunotherapy for house dust mite respiratory allergic disease in Denmark.

    Science.gov (United States)

    Rønborg, Steen; Johnsen, Claus R; Theilgaard, Sune; Winther, Anders; Hahn-Pedersen, Julie; Andreasen, Jakob Nørgaard; Olsen, Jens

    2016-08-01

    Objectives Currently, patients with persistent moderate-to-severe house dust mite (HDM) allergic rhinitis despite use of symptom-relieving medication can be offered subcutaneously administered allergy immunotherapy (SQ SCIT; Alutard SQ) as standard care of treatment in Denmark. Recently, a HDM sublingually administered allergy immunotherapy tablet (SQ SLIT-tablet; ACARIZAX) has been developed for at-home treatment. The purpose of this analysis is to compare the costs related to treatment and administration of SQ SLIT-tablet and SQ SCIT. Methods Assuming equal efficacy between ther SQ SLIT-tablet and SQ SCIT, the cost-minimization analysis was the most appropriate for the comparison. According to guidelines and Summary of Product Characteristics, the treatment duration of SQ SLIT-tablet is 3 years and 3-5 years for SQ SCIT. The courses of treatment vary among patients and, therefore, the costs of treatment have been calculated for an average patient with HDM respiratory allergic disease (RAD) receiving either SQ SLIT-tablet or SQ SCIT. All costs associated with allergy immunotherapy were collected, i.e., cost of medication, administration and treatment setting, and discounted according to Danish guidelines. Comprehensive univariate sensitivity analyses were carried out. Results The treatment costs for an average patient with HDM RAD are €3094 for SQ SLIT-tablet and €3799 for SQ SCIT; however, when adding indirect costs to the calculations the total costs of the treatments are €3697 and €6717 for SQ SLIT-tablet and SQ SCIT, respectively. Therefore, if 2500 patients with HDM RAD were treated with SQ SLIT-tablet instead of SQ SCIT, it would elicit a saving to the healthcare system of ∼€1.8 million. The conclusion was robust to any changes in the sensitivity analysis. Conclusion With regards to the cost of treating Danish patients with HDM RAD, it is clearly cost-saving to treat patients with SQ SLIT-tablet compared to SQ SCIT. PMID:26909663

  4. The complete mitochondrial genome of the house dust mite Dermatophagoides pteronyssinus (Trouessart: a novel gene arrangement among arthropods

    Directory of Open Access Journals (Sweden)

    Vanholme Bartel

    2009-03-01

    Full Text Available Abstract Background The apparent scarcity of available sequence data has greatly impeded evolutionary studies in Acari (mites and ticks. This subclass encompasses over 48,000 species and forms the largest group within the Arachnida. Although mitochondrial genomes are widely utilised for phylogenetic and population genetic studies, only 20 mitochondrial genomes of Acari have been determined, of which only one belongs to the diverse order of the Sarcoptiformes. In this study, we describe the mitochondrial genome of the European house dust mite Dermatophagoides pteronyssinus, the most important member of this largely neglected group. Results The mitochondrial genome of D. pteronyssinus is a circular DNA molecule of 14,203 bp. It contains the complete set of 37 genes (13 protein coding genes, 2 rRNA genes and 22 tRNA genes, usually present in metazoan mitochondrial genomes. The mitochondrial gene order differs considerably from that of other Acari mitochondrial genomes. Compared to the mitochondrial genome of Limulus polyphemus, considered as the ancestral arthropod pattern, only 11 of the 38 gene boundaries are conserved. The majority strand has a 72.6% AT-content but a GC-skew of 0.194. This skew is the reverse of that normally observed for typical animal mitochondrial genomes. A microsatellite was detected in a large non-coding region (286 bp, which probably functions as the control region. Almost all tRNA genes lack a T-arm, provoking the formation of canonical cloverleaf tRNA-structures, and both rRNA genes are considerably reduced in size. Finally, the genomic sequence was used to perform a phylogenetic study. Both maximum likelihood and Bayesian inference analysis clustered D. pteronyssinus with Steganacarus magnus, forming a sistergroup of the Trombidiformes. Conclusion Although the mitochondrial genome of D. pteronyssinus shares different features with previously characterised Acari mitochondrial genomes, it is unique in many ways. Gene

  5. Randomized double-blind placebo-controlled trial of sublingual immunotherapy in children with house dust mite allergy in primary care: study design and recruitment

    Directory of Open Access Journals (Sweden)

    de Jongste Johan C

    2008-10-01

    Full Text Available Abstract Background For respiratory allergic disorders in children, sublingual immunotherapy has been developed as an alternative to subcutaneous immunotherapy. Sublingual immunotherapy is more convenient, has a good safety profile and might be an attractive option for use in primary care. A randomized double-blind placebo-controlled study was designed to establish the efficacy of sublingual immunotherapy with house dust mite allergen compared to placebo treatment in 6 to18-year-old children with allergic rhinitis and a proven house dust mite allergy in primary care. Described here are the methodology, recruitment phases, and main characteristics of the recruited children. Methods Recruitment took place in September to December of 2005 and 2006. General practitioners (in south-west Netherlands selected children who had ever been diagnosed with allergic rhinitis. Children and parents could respond to a postal invitation. Children who responded positively were screened by telephone using a nasal symptom score. After this screening, an inclusion visit took place during which a blood sample was taken for the RAST test. Results A total of 226 general practitioners invited almost 6000 children: of these, 51% was male and 40% Conclusion Our study was designed in accordance with recent recommendations for research on establishing the efficacy of sublingual immunotherapy; 98% of the target sample size was achieved. This study is expected to provide useful information on sublingual immunotherapy with house dust mite allergen in primary care. The results on efficacy and safety are expected to be available by 2010. Trial registration the trial is registered as ISRCTN91141483 (Dutch Trial Register

  6. In Vivo and In Vitro Studies of Th17 Response to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients

    OpenAIRE

    Li, Chun Wei; Lu, Han Gui; Chen, Hua; Lin, Zhi Bin; Wang, Yun; Li, Tian Ying

    2014-01-01

    T helper (Th)17 cells have been implicated in the development of allergic rhinitis (AR), but their response to specific immunotherapy (SIT) remains unclear. We investigated the impact of SIT on Th17 response and Th1/Th2 changes in AR patients. Blood samples from AR patients (n = 20) who were monosensitized to house dust mite (HDM) were collected before the initiation of SIT (SIT-untreated) and after the end of 2-year SIT (SIT-treated) treatment. Twenty healthy volunteers were recruited as con...

  7. Building a Mien-American house: A case study in school-community relations

    Science.gov (United States)

    Hammond, Lorie A.

    2000-10-01

    Researchers and policymakers agree that schools and parents must work together if they are to provide the sustenance, services, and support which children need to be successful in our increasingly complex society. (Clark, 1983; Comer, 1980, 1996; Clinton, 1995; Epstein, 1995, 1996). Unfortunately, the social and academic success of language minority students is often adversely affected by the alienation of parents from school culture and by the "deficit" view which teachers hold of language minority parents' academic and parenting skills (Boggs, 1985; Delgado-Gaitan, 1990; Heath, 1983; Lareau, 1987, 1989; Philips, 1983). This case study describes the attempts of one school site to build academic and social bridges between immigrant families from a Southeast Asian Hill Tribe, the Iu Mien, and a mainstream elementary school. This effort is facilitated by a constructivist approach to curriculum in which parents, teachers, and children create an intercultural space---a school community garden---as a context in which academic dialogue can occur. Various strategies which enable inter-cultural learning are described, including the use of students as ethnographers, of parents as expert teachers, and of teachers as cultural brokers. The study also considers the cultural conflicts and understandings which occurred when American teachers and Mien parents built a Mien field-house together: a structure which became symbolic of their blended lives. Through both a descriptive narration and interviews with various participants, the study analyzes (a) community-based curriculum development, led by practitioner reformers, as a way to enable language minority students to be academically successful within their own life worlds, as well as (b) the political and bureaucratic forces which make community-based reforms difficult to sustain. This study employs qualitative research strategies within an action-research context in which the author plays the dual role of practitioner reformer

  8. Relationship between Housing Status and Retention Rates among HIV-Positive African Americans Enrolled in a Comprehensive Care Program.

    Science.gov (United States)

    Xiao, Hong; Mains, William

    2016-01-01

    Service provision using "one-stop shopping" of medical, psychiatric, and case management services at the same location has been associated with superior client retention. The Yadumu project tested this premise, with attention to HIV-infected African Americans. Each client was assigned a case manager, who arranged meetings with mental health, substance abuse, and medical care professionals. The Center for Mental Health Services, National Outcome Measures (CMHS NOMs) questionnaire was used to evaluate client progress. Data were collected longitudinally and the program evaluation was performed by an outside center. Among 129 clients, 47% were male, 30% were female, and 22% were transgender. The majority (72%) were African American. Clients who lived in detox/drug treatment programs had higher completion rates (48%) than those who were homeless or otherwise housed (28%) (p = 0.04). Logistic regression was used to assess associations between independent factors and retention. Clients satisfied with their housing situation were less likely to retain in the program than those who were not satisfied with their housing situation (OR = 0.15, 95% CI: 0.03-0.78). High discharge rates among HIV-infected people were observed and may reflect the unstable circumstances of the population studied, but structured residential programs could be advantageous for improving retention. PMID:26960017

  9. Intensification of North American Megadroughts through Surface and Dust Aerosol Forcing

    Science.gov (United States)

    Cook, Benjamin I.; Seager, Richard; Miller, Ron L.; Mason, Joseph A

    2013-01-01

    Tree-ring-based reconstructions of the Palmer drought severity index (PDSI) indicate that, during the Medieval Climate Anomaly (MCA), the central plains of North America experienced recurrent periods of drought spanning decades or longer. These megadroughts had exceptional persistence compared to more recent events, but the causes remain uncertain. The authors conducted a suite of general circulation model experiments to test the impact of sea surface temperature (SST) and land surface forcing on the MCA megadroughts over the central plains. The land surface forcing is represented as a set of dune mobilization boundary conditions, derived from available geomorphological evidence and modeled as increased bare soil area and a dust aerosol source (32deg-44degN, 105deg-95degW). In the experiments, cold tropical Pacific SST forcing suppresses precipitation over the central plains but cannot reproduce the overall drying or persistence seen in the PDSI reconstruction. Droughts in the scenario with dust aerosols, however, are amplified and have significantly longer persistence than in other model experiments, more closely matching the reconstructed PDSI. This additional drying occurs because the dust increases the shortwave planetary albedo, reducing energy inputs to the surface and boundary layer. The energy deficit increases atmospheric stability, inhibiting convection and reducing cloud cover and precipitation over the central plains. Results from this study provide the first model-based evidence that dust aerosol forcing and land surface changes could have contributed to the intensity and persistence of the central plains megadroughts, although uncertainties remain in the formulation of the boundary conditions and the future importance of these feedbacks.

  10. Housing and Social Environments of African (Loxodonta africana) and Asian (Elephas maximus) Elephants in North American Zoos

    Science.gov (United States)

    Meehan, Cheryl L.; Hogan, Jennifer N.; Bonaparte-Saller, Mary K.; Mench, Joy A.

    2016-01-01

    We evaluated 255 African (Loxodonta africana) and Asian (Elephas maximus) elephants living in 68 North American zoos over one year to quantify housing and social variables. All parameters were quantified for the both the day and the night and comparisons were made across these time periods as well as by species and sex. To assess housing, we evaluated not only total exhibit size, but also individual animals’ experiences based on the time they spent in the unique environments into which the exhibits were subdivided. Variables developed to assess housing included measurements of area as a function of time (Total Space Experience), environment type (Indoor, Outdoor, In/Out Choice) and time spent on hard and soft flooring. Over the year, Total Space Experience values ranged from 1,273 square feet to 169,692 square feet, with Day values significantly greater than Night values (panimals functionally housed together (Social Experience) and social group characteristics such as time spent with juveniles and in mixed-sex groups. Overall Social Experience scores ranged from 1 to 11.2 and were significantly greater during the Day than at Night (pwelfare outcomes. PMID:27414034

  11. Rushing into American Dream? House Prices, Timing of Homeownership, and Adjustment of Consumer Credit

    OpenAIRE

    Agarwal, Sumit; Hu, Luojia; Huang, Xing

    2013-01-01

    In this paper we use a large panel of individuals from Consumer Credit Panel dataset to study the timing of homeownership as a function of credit constraints and expectations of future house price. Our panel data allows us to track individuals over time and we model the transition probability of their first home purchase. We find that in MSAs with highest quartile house price growth, the median individual become homeowners earlier by 5 years in their lifecycle compared to MSAs with lowest qua...

  12. The Metropolitan Military : Navy Families and Housing in the American Sunbelt, 1941 - 2000

    OpenAIRE

    Reft, Ryan

    2014-01-01

    "The Metropolitan Military" examines military family housing from 1941 to 2000 and argues post-World War II militarization shaped the processes of suburbanization and urbanization and concepts regarding citizenship. During the 1950s and 60s, real estate interests and municipalities opposed military housing on the grounds that it threatened segregation, promoted socialism, and competed unfairly with private business. After a decade of economic turmoil and tax revolts, individual homeowners too...

  13. Unheard and Unseen: How Housing Insecure African American Adolescents Experience the Education System

    Science.gov (United States)

    Ellis, Addie Lucille; Geller, Kathy D.

    2016-01-01

    This narrative study is based on stories told by African American adolescents experiencing homelessness. It offers insights into their lived experiences and describes the challenges faced in negotiating the urban education system. African American youth are disproportionately represented in the adolescent homeless demographic. "Unheard and…

  14. A Qualitative Examination of Health Barriers and Facilitators Among African American Mothers in a Subsidized Housing Community.

    Science.gov (United States)

    Cotter, Elizabeth W; Hamilton, Natia S; Kelly, Nichole R; Harney, Megan B; Greene, LaShaun; White, Kelly A; Mazzeo, Suzanne E

    2016-09-01

    Although African American families are at particular risk for obesity and its associated health comorbidities, few interventions have directly targeted low-income members of this group living in subsidized public housing. Using a consensual qualitative research approach, we conducted 11 interviews with African American mothers living in two public housing communities to enhance understanding of their perceived barriers and facilitators to health. Five primary domains emerged, including barriers (access, financial, personal, and neighborhood concerns), resources (personal and community), current behaviors (diet, physical activity, and program participation), definition of health (mental well-being, physical well-being, and health behaviors), and needs/interests in programming (health behavior-specific programs, non-health-related programs, child-focused programming, and qualities of programs and their leaders). Results demonstrate the complex interaction among social, environmental, and personal factors on health behaviors for this priority population, and highlight the need for community members' involvement in the development of community-based obesity prevention programming. PMID:27091605

  15. Safety, tolerability, and impact on allergic inflammation of autologous E.coli autovaccine in the treatment of house dust mite asthma - a prospective open clinical trial

    Directory of Open Access Journals (Sweden)

    Schulze Johannes

    2011-06-01

    Full Text Available Abstract Background Asthma is increasing worldwide and results from a complex immunological interaction between genetic susceptibility and environmental factors. Autovaccination with E. coli induces a strong TH-1 immune response, thus offering an option for the treatment of allergic diseases. Methods Prospective open trial on safety, tolerability, and impact on allergic inflammation of an autologous E.coli autovaccine in intermittent or mild persistent house dust mite asthma. Determination of exhaled nitric monoxide (eNO before and after bronchial mite challenge initially and after nine months of autovaccination. Results In nine subjects and a total of 306 injections, we observed 101 episodes of local erythema (33.3%; median of maximal diameter 2.5 cm, 95 episodes of local swelling (31.1%; median of maximal diameter 3 cm, and 27 episodes of local pain (8.8%. Four subjects reported itching at the injection site with a total of 30 episodes (9.8%. Median eNO increase after autovaccination was significantly smaller (from 27.3 to 33.8 ppb; p = 0.334 compared to initial values (from 32.6 to 42.2 ppb; p = 0.046 (p = 0.034. We observed no serious adverse events. All organ functions (inclusive electrocardiogramm and laboratory testing of the blood (clinical chemistry, hematology and the urine (screening test, Β-microglobuline were within normal limits. Vital signs undulated within the physiological variability. Conclusion The administration of autologous autovacine for the treatment of house dust mite asthma resulted in a reduction of the eNO increase upon bronchial mite challenge. In nine subjects and 306 injections, only a few mild local reactions and no systemic severe adverse events were observed. Trial registration EudraCT Nr. 2005-005534-12 ClinicalTrials.gov ID NCT00677209

  16. Modification of the late asthmatic reaction by hyposensitization in asthmatic children allergic to house dust mite (Dermatophagoides pteronyssinus) or grass pollen.

    Science.gov (United States)

    Van Bever, H P; Bosmans, J; De Clerck, L S; Stevens, W J

    1988-07-01

    The frequency and severity of the late asthmatic reaction (LAR) was studied in asthmatic children allergic to house dust mite (HDM) or grass pollen (GP) with and without hyposensitization (HS). The four groups were comparable according to their severity of asthma. All children were allergic to HDM (Dermatophagoides pteronyssinus) or GP according to history, skin testing and specific IgE determination via the RAST. The LAR occurred less frequently (29% versus 73%) (P less than 0.001) and was less severe in children receiving HS. The difference was significant between the children allergic to HDM as well as between children allergic to GP. The immediate asthmatic reaction (IAR) was also less severe in children allergic to HDM who received HS, compared to those who never received HS, (P = 0.033) although the PD20 of the HDM challenge (PD20HDM) was not different between the two groups. In children allergic to GP, there was no difference in PD20 of the GP challenge (PD20GP) or in severity of the IAR, whether the children received HS or not. There was no difference between the PD20HDM in patients who developed a LAR and in patients who did not. There was no relation between the type of asthmatic reaction following the allergen provocation test and the level of circulating immune complexes (CIC) and the level of house dust mite-specific IgG (IgGHDM) or grass pollen-specific IgE (IgGGP) in the different groups, determined before the challenge. There was a decrease in the level of IgG containing CIC (IgGCIC) during the LAR. It is concluded that the LAR occurs less frequently and is less severe in asthmatic children who receive HS. PMID:3414914

  17. Determinants of house dust, endotoxin, and β-(1→3)-d-glucan in homes of Danish children

    DEFF Research Database (Denmark)

    Holst, Gitte Juel; Høst, Arne; Doekes, G; Meyer, Harald W; Madsen, Anne-Mette; Sigsgaard, Torben

    2015-01-01

    potential determinants. We found: geometric means (geometric standard deviations) 186 mg/m(2) (4.3) for dust; 5.46 × 10(3) EU/m(2) (8.0) and 31.1 × 10(3) EU/g (2.6) for endotoxin; and 142 μg/m(2) (14.3) and 0.71 × 10(3) μg/g (7.3) for β-(1→3)-d-glucan. High correlations (r > 0.75) were found between floor...

  18. Validation of the cyclone as a pre-separator for airborne fine dust sampling in animal houses

    OpenAIRE

    Aarnink, A.J.A.; Yang Zhao, Yang; Hofschreuder, P.; Ogink, N.W.M.

    2008-01-01

    The aim of this study was to verify the overloading of greased impaction pre-separators (IPs) in samplers for PM10 and PM2.5. Furthermore, the use of cyclone pre-separators (CPs) as equivalent samplers, which are less vulnerable for overloading, was validated. In the overloading test, the greased plates of IPs were replaced by new ones at different time intervals. Additional validating tests were conducted in different animal houses (pigs and poultry), in a technical lab, and in ambient air. ...

  19. Exposure to soil, house dust and decaying plants increases gut microbial diversity and decreases serum immunoglobulin E levels in BALB/c mice.

    Science.gov (United States)

    Zhou, Dongrui; Zhang, Honglin; Bai, Zhimao; Zhang, Aidi; Bai, Futian; Luo, Xing; Hou, Yue; Ding, Xiao; Sun, Beili; Sun, Xiao; Ma, Ning; Wang, Cuifen; Dai, Xiaoniu; Lu, Zuhong

    2016-05-01

    To assess the impact of sanitation of a living environment on gut microbiota and development of the immune system, we raised BALB/c mice under three distinct environmental conditions: a specific pathogen-free animal room (SPF), a general animal room (XZ) and a farmhouse (JD). All other variables like diet, age, genetic background, physiological status and original gut microbiota were controlled for in the three groups. Using high-throughput sequencing of the 16S rRNA gene, we found that each mouse group had a specific structure of the gut microbial community. Groups JD and XZ harboured a significantly more diverse and richer gut microbiota than did group SPF. Bacteroidetes were significantly more abundant in groups XZ and JD than in group SPF, whereas Firmicutes showed the inverse pattern. Total serum immunoglobulin E (IgE) levels were significantly lower in groups XZ and JD than in group SPF. There were no significant differences in gut microbiota diversity and serum IgE concentration between groups JD and XZ, but we found higher abundance of dominant genera in the gut microflora of group JD. We conclude that exposure to soil, house dust and decaying plant material enhances gut microbial diversity and innate immunity. Our results seem to provide new evidence supporting the hygiene hypothesis. PMID:25958920

  20. Extracellular superoxide dismutase ameliorates house dust mite-induced atopic dermatitis-like skin inflammation and inhibits mast cell activation in mice.

    Science.gov (United States)

    Lee, Yun Sang; Choi, Jung-Hye; Lee, Ji-Hyun; Lee, Han-Woong; Lee, Weontae; Kim, Woo Taek; Kim, Tae-Yoon

    2016-08-01

    Extracellular superoxide dismutase (EC-SOD) is an enzyme that catalyses the dismutation of superoxide anions. It has multiple functions, such as reactive oxygen species scavenging, anti-angiogenic, anti-inflammatory, antichemotatic and antitumor activities. Recently, we demonstrated that EC-SOD inhibits ovalbumin-induced allergic airway inflammation in mice. However, the anti-allergic effect of EC-SOD on skin tissue and the role of EC-SOD in mast cells, which are important for allergic responses, have not been well studied. In this study, we investigated whether EC-SOD can alleviate atopic dermatitis in mice and inhibit mast cell activation. Treatment with human recombinant EC-SOD ameliorated house dust mite-induced atopic dermatitis in mice. Furthermore, the levels of pro-allergic cytokine gene expression and histamine release increased in EC-SOD KO mast cells and decreased in EC-SOD overexpressing mast cells, suggesting that EC-SOD inhibits mast cell activation. Consistently, a passive cutaneous anaphylaxis experiment showed more blood leakage from EC-SOD KO mouse ear skin, implying that the lack of EC-SOD increases allergic responses. These results suggest that EC-SOD inhibits mast cell activation and atopic dermatitis and that the loss of EC-SOD causes more severe allergic responses, implying that EC-SOD might be a good drug candidate for treatment of allergic disorders, such as atopic dermatitis. PMID:27061078

  1. The Hot-Water Extract of Smilacis Chinae Rhizome Suppresses 2,4-Dinitrochlorobenzene and House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions in Mice.

    Science.gov (United States)

    Ki, Nam Yong; Park, Eun-Ji; Sung, In Sung; Ju, Seul A; Kim, Kyoung Un; Kim, Mi Rae; Song, Do Yeon; Lee, Min-Ju; Kim, Hak-Soo; Kang, Boo-Hyon; Chung, Hun-Jong; Choi, Eun-Ju; Yoon, Ki-Hun; Lee, Min Won; Yun, Seongho; Min, Bokkee; Kwon, Suk Hyung; Shin, Hwa-Sup

    2016-04-01

    Smilacis Chinae Rhizome (SCR) has been used as an oriental folk medicine for various biological activities. However, its effect on atopic dermatitis (AD) remains undetermined to date. We assessed the effect of orally administered hot-water extract of SCR on AD-like skin lesions in mice and its underlying mechanisms. AD-like murine model was prepared by repeated alternate application of house dust mite (Dermatophagoides farinae) extract (DFE) and 2,4-dinitrochlorobenzene (DNCB) for 4 weeks, topically to the ears. Daily oral administration of SCR for 3 and 4 weeks significantly reduced inflammatory ear thickening, with the effect being enhanced at the earlier start and longer period of administration. This effect was accompanied by a significant decrease in both Th2 and Th1 serum antibodies (total IgE, DFE-specific IgE, and IgG2a). Histological analysis showed that SCR markedly decreased the epidermal/dermal ear thickening and the dermal infiltration of inflammatory cells. Furthermore, SCR suppressed DFE/DNCB-induced expression of IL-4, IL-13, IL-17, IL-18, TSLP, and IFN-γ genes in the ear tissue. Taken together, our observations demonstrate that chronic oral administration of SCR exerts beneficial effect in mouse AD model, suggesting that SCR has the therapeutic potential as an orally active treatment of AD by modulating both Th1 and Th2 responses. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26840656

  2. The House, the Street and the Brothel: Gender in Latin American History

    Directory of Open Access Journals (Sweden)

    Elizabeth Kuznesof

    2013-04-01

    Full Text Available This article delineates scholarship in Latin American history (mostly in English defined by gender relations and/or focused on women. From 1492 until 1750, the honor code, the process of miscegenation or race mixture, and property rights are emphasized. Scholarship has overturned the traditional view that colonial households and production were invariably patriarchal, since between 25 to 45 percent of households were headed by women. Illegitimacy and consensual unions were found to be prevalent principally among the non-white and non-elite populations. From 1750 to 1930, profound and contradictory changes included a secularization process that caused women’s loss of many colonial protections. However, new opportunities developed for women’s employment and control of property. Women were essentially controlled within the private sphere during the colonial period, but that control moved to the workplace in the nineteenth century, and to the state in the early twentieth century. Gender was an important discourse in struggles to define the nation-state, with prostitution and disease as central themes. In the twentieth century social historians have demonstrated the differential gender impacts of economic and technological change brought by development projects, industrialization, and shifting strategies of multinational corporations. The most striking contributions of recent books on gender in Latin America include the continuing significance of honor after independence. Motherhood is another recurring theme in writings about women and their history in Latin America.

  3. Housing Affordability Data System (HADS)

    Data.gov (United States)

    Department of Housing and Urban Development — The Housing Affordability Data System (HADS) is a set of files derived from the 1985 and later national American Housing Survey (AHS) and the 2002 and later Metro...

  4. Co-Designing Sustainable Communities: The Identification and Incorporation of Social Performance Metrics in Native American Sustainable Housing and Renewable Energy System Design

    OpenAIRE

    Shelby, Ryan

    2013-01-01

    Co-Designing Sustainable Communities: The Identification and Incorporation of Social Performance Metrics in Native American Sustainable Housing and Renewable Energy System DesignBy: Ryan L. Shelby Doctor of Philosophy in Mechanical EngineeringUniversity of California, BerkeleyProfessor Alice M. Agogino, ChairOver the last quarter-century, the twin concepts of sustainability and sustainable development have emerged as a defining imperative of humanity that is situated at the nexus of science, ...

  5. Lung-homing of endothelial progenitor cells and airway vascularization is only partially dependant on eosinophils in a house dust mite-exposed mouse model of allergic asthma.

    Directory of Open Access Journals (Sweden)

    Nirooya Sivapalan

    Full Text Available Asthmatic responses involve a systemic component where activation of the bone marrow leads to mobilization and lung-homing of progenitor cells. This traffic may be driven by stromal cell derived factor-1 (SDF-1, a potent progenitor chemoattractant. We have previously shown that airway angiogenesis, an early remodeling event, can be inhibited by preventing the migration of endothelial progenitor cells (EPC to the lungs. Given intranasally, AMD3100, a CXCR4 antagonist that inhibits SDF-1 mediated effects, attenuated allergen-induced lung-homing of EPC, vascularization of pulmonary tissue, airway eosinophilia and development of airway hyperresponsiveness. Since SDF-1 is also an eosinophil chemoattractant, we investigated, using a transgenic eosinophil deficient mouse strain (PHIL whether EPC lung accumulation and lung vascularization in allergic airway responses is dependent on eosinophilic inflammation.Wild-type (WT BALB/c and eosinophil deficient (PHIL mice were sensitized to house dust mite (HDM using a chronic exposure protocol and treated with AMD3100 to modulate SDF-1 stimulated progenitor traffic. Following HDM challenge, lung-extracted EPCs were enumerated along with airway inflammation, microvessel density (MVD and airway methacholine responsiveness (AHR.Following Ag sensitization, both WT and PHIL mice exhibited HDM-induced increase in airway inflammation, EPC lung-accumulation, lung angiogenesis and AHR. Treatment with AMD3100 significantly attenuated outcome measures in both groups of mice. Significantly lower levels of EPC and a trend for lower vascularization were detected in PHIL versus WT mice.This study shows that while allergen-induced lung-homing of endothelial progenitor cells, increased tissue vascularization and development lung dysfunction can occur in the absence of eosinophils, the presence of these cells worsens the pathology of the allergic response.

  6. Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite.

    Directory of Open Access Journals (Sweden)

    Zhuang-Gui Chen

    Full Text Available Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. However, the initiating factor that links airway inflammation to remodeling is unknown. Thymic stromal lymphopoietin (TSLP, an epithelium-derived cytokine, can strongly activate lung dendritic cells (DCs through the TSLP-TSLPR and OX40L-OX40 signaling pathways to promote Th2 differentiation. To determine whether TSLP is the underlying trigger of airway remodeling in chronic allergen-induced asthma, we induced allergic airway inflammation in mice by intranasal administration of house dust mite (HDM extracts for up to 5 consecutive weeks. We showed that repeated respiratory exposure to HDM caused significant airway eosinophilic inflammation, peribronchial collagen deposition, goblet cell hyperplasia, and airway hyperreactivity (AHR to methacholine. These effects were accompanied with a salient Th2 response that was characterized by the upregulation of Th2-typed cytokines, such as IL-4 and IL-13, as well as the transcription factor GATA-3. Moreover, the levels of TSLP and transforming growth factor beta 1 (TGF-β1 were also increased in the airway. We further demonstrated, using the chronic HDM-induced asthma model, that the inhibition of Th2 responses via neutralization of TSLP with an anti-TSLP mAb reversed airway inflammation, prevented structural alterations, and decreased AHR to methacholine and TGF-β1 level. These results suggest that TSLP plays a pivotal role in the initiation and persistence of airway inflammation and remodeling in the context of chronic allergic asthma.

  7. In Utero exposure to genistein enhanced intranasal house dust mite allergen-induced respiratory sensitization in young adult B6C3F1 mice.

    Science.gov (United States)

    Guo, Tai L; Meng, Andrew H

    2016-06-24

    Despite many hypothesized benefits of dietary isoflavone genistein (GEN) deriving from soy-based products, questions surrounding GEN's developmental immunotoxic effects are increasing. To understand how in utero GEN exposure may modulate postnatal respiratory sensitization, we conducted a time course study using a common household allergen (house dust mites: HDM; 10μg/mouse) following intranasal instillation, a physiological route of allergen exposure. GEN was administered to dams by gavage from gestational day 14 to parturition at a physiologically relevant dose (20mg/kg bw). Female and male offspring were sensitized with HDM allergens beginning about one month prior to sacrifice followed by challenges with three weekly doses of HDM extracts, and they were euthanized at day 3 following the final HDM exposure at four different time points (postnatal day (PND) 80, 120, 160, and 200). In utero GEN combined with postnatal HDM exposures (GEN+HDM) increased total IgE production in both young female and male B6C3F1 offspring (e.g., PND 80 in females and PND 120 in males). Increased antigen-specific IgG1, IgG2a and IgG2b levels were also observed at various time points in both female and male offspring. In addition, increases in macrophage number in bronchoalveolar lavage fluid of both female and male GEN+HDM offspring at PND 80 and PND 120, respectively, were observed when compared to the vehicle group. For T cells, an increase over the vehicle in female GEN+HDM offspring was observed at PND 80. Due to similar patterns of increases, it seems likely that GEN+HDM-induced increases in total IgE and macrophages are related. Overall, in utero GEN plus later-life HDM exposures exert increases in total IgE and HDM-specific IgG production as well as macrophage recruitments to the lung in young adult mice. PMID:27113705

  8. Interleukin-33 from Monocytes Recruited to the Lung Contributes to House Dust Mite-Induced Airway Inflammation in a Mouse Model.

    Directory of Open Access Journals (Sweden)

    Hiroki Tashiro

    Full Text Available Interleukin-33 (IL-33 activates group 2 innate lymphoid cells (ILC2, resulting in T-helper-2 inflammation in bronchial asthma. Airway epithelial cells were reported as sources of IL-33 during apoptosis and necrosis. However, IL-33 is known to be from sources other than airway epithelial cells such as leukocytes, and the mechanisms of IL-33 production and release are not fully understood. The aim of this study was to clarify the role of IL-33 production by monocytes in airway inflammation.BALB/c mice were sensitized and challenged with a house dust mite (HDM preparation. Airway inflammation was assessed by quantifying inflammatory cells in bronchoalveolar lavage (BAL fluid, and IL-25, IL-33, and thymic stromal lymphopoietin (TSLP levels in lung. Immunohistochemistry for IL-33 in lung sections was also performed. Ly6c, CD11b, and CD11c expression was examined by flow cytometry. Clodronate liposomes were used in the HDM-airway inflammation model to deplete circulating monocytes.The IL-33, but not IL-25 or TSLP, level in lung homogenates was markedly increased in HDM mice compared to control mice. IL-33-positive cells in the lungs were identified using immunohistochemistry and were increased in areas surrounding bronchi and vasculature. Furthermore, IL-33 levels were increased in mononuclear cells derived from lungs of HDM mice compared to controls. The expression of Ly6c in mononuclear cells was significantly higher in HDM mice than in controls. Treatment with clodronate liposomes led to inhibition of not only inflammatory cells in BAL fluid, airway hyper reactivity and Th2 cytokines in lung, but also IL-33 in lung.IL-33 from monocytes recruited to the lung may contribute to the pathogenesis of HDM-induced airway inflammation.

  9. Evaluation of autologous serum skin test and skin prick test reactivity to house dust mite in patients with chronic spontaneous urticaria.

    Directory of Open Access Journals (Sweden)

    Zhiqiang Song

    Full Text Available BACKGROUND: Chronic spontaneous urticaria (CSU is a common skin disorder with etiology that is not well understood. METHODS: In this study, we evaluated the prevalence of autologous serum skin test (ASST and skin prick testing (SPT to house dust mite (HDM in 862 CSU cases in China. Clinical features, courses and treatment responses were also recorded. RESULTS: The prevalence of positive ASST was 46.3%, and patients aged 30-39 years had the highest positive rate (52.1%. Positive SPT to HDM was seen in 153 patients (17.7% with the highest positive rate (34.2% in patients aged 20 or less. Patients with positive ASST had higher urticaria activity scores (UAS (4.18±0.65 vs. 3.67±0.53 but lower positive rates of HDM (24.6% vs. 37.6%, as compared with those with negative ASST (odds ratio (OR 1.84, 95% CI 1.38-2.47. Patients could be categorized into four groups based on the results of ASST and SPT to HDM and patients with positive ASST and positive SPT to HDM had the highest disease activity scores, experienced higher frequencies of angioedema, diseases duration, and required higher dosage of loratadine every month, compared with other subgroups (P<0.0001. CONCLUSIONS: Patients with CSU showed varied responses of positive ASST and varied sensitivity to HDM, Patients with positive ASST and/or positive SPT had more disease activity compared with patients with negative ASST and/or negative SPT. Further classification can be made based on the result of SPT and ASST.

  10. Innate immune response of alveolar macrophage to house dust mite allergen is mediated through TLR2/-4 co-activation.

    Directory of Open Access Journals (Sweden)

    Chia-Fang Liu

    Full Text Available House dust mite, Dermatophagoides pteronyssinus (Der p, is one of the major allergens responsible for allergic asthma. However, the putative receptors involved in the signalization of Der p to the innate immune cells are still poorly defined as well as the impact of their activation on the outcome of the allergen-induced cell response. We previously reported that the HDM activation of mouse alveolar macrophages (AM involves the TLR4/CD14 cell surface receptor complex. Here using a TLR ligand screening essay, we demonstrate that HDM protein extract engages the TLR2, in addition to the TLR4, in engineered TLR-transfected HEK cells but also in the MH-S mouse alveolar macrophage cell line model. Moreover we found that the concomitant recruitment of the MH-S cell's TLR2 and TLR4 receptors by the HDM extract activates the MyD88-dependent signaling pathway and leads to the secretion of the NF-κB regulated pro-inflammatory factors NO and TNF-α. However unlike with the canonical TLR4 ligand (i.e. the bacterial LPS mobilization of TLR4 by the HDM extract induces a reduced production of the IL-12 pro-inflammatory cytokine and fails to trigger the expression of the T-bet transcription factor. Finally we demonstrated that HDM extract down-regulates LPS induced IL-12 and T-bet expression through a TLR2 dependent mechanism. Therefore, we propose that the simultaneous engagement of the TLR2 and TLR4 receptors by the HDM extract results in a cross regulated original activation pattern of the AM which may contribute to the Th2 polarization of the allergen-induced immune response. The deciphering of these cross-regulation networks is of prime importance to open the way for original therapeutic strategies taking advantage of these receptors and their associated signaling pathways to treat allergic asthma.

  11. Interleukin-33 from Monocytes Recruited to the Lung Contributes to House Dust Mite-Induced Airway Inflammation in a Mouse Model

    Science.gov (United States)

    Tashiro, Hiroki; Takahashi, Koichiro; Hayashi, Shinichiro; Kato, Go; Kurata, Keigo; Kimura, Shinya; Sueoka-Aragane, Naoko

    2016-01-01

    Background Interleukin-33 (IL-33) activates group 2 innate lymphoid cells (ILC2), resulting in T-helper-2 inflammation in bronchial asthma. Airway epithelial cells were reported as sources of IL-33 during apoptosis and necrosis. However, IL-33 is known to be from sources other than airway epithelial cells such as leukocytes, and the mechanisms of IL-33 production and release are not fully understood. The aim of this study was to clarify the role of IL-33 production by monocytes in airway inflammation. Methods BALB/c mice were sensitized and challenged with a house dust mite (HDM) preparation. Airway inflammation was assessed by quantifying inflammatory cells in bronchoalveolar lavage (BAL) fluid, and IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) levels in lung. Immunohistochemistry for IL-33 in lung sections was also performed. Ly6c, CD11b, and CD11c expression was examined by flow cytometry. Clodronate liposomes were used in the HDM-airway inflammation model to deplete circulating monocytes. Results The IL-33, but not IL-25 or TSLP, level in lung homogenates was markedly increased in HDM mice compared to control mice. IL-33-positive cells in the lungs were identified using immunohistochemistry and were increased in areas surrounding bronchi and vasculature. Furthermore, IL-33 levels were increased in mononuclear cells derived from lungs of HDM mice compared to controls. The expression of Ly6c in mononuclear cells was significantly higher in HDM mice than in controls. Treatment with clodronate liposomes led to inhibition of not only inflammatory cells in BAL fluid, airway hyper reactivity and Th2 cytokines in lung, but also IL-33 in lung. Conclusion IL-33 from monocytes recruited to the lung may contribute to the pathogenesis of HDM-induced airway inflammation. PMID:27310495

  12. The effects of inhaled corticosteroids on intrinsic responsiveness and histology of airways from infant monkeys exposed to house dust mite allergen and ozone

    International Nuclear Information System (INIS)

    Inhaled corticosteroids (ICS) are recommended to treat infants with asthma, some with intermittent asthma. We previously showed that exposing infant monkeys to allergen/ozone resulted in asthma-like characteristics of their airways. We evaluated the effects of ICS on histology and intrinsic responsiveness of allergen/ozone-exposed and normal infant primate airways. Infant monkeys were exposed by inhalation to (1) filtered air and saline, (2) house dust mite allergen (HDMA) + ozone and saline, (3) filtered air and ICS (budesonide) or (4) HDMA + ozone and ICS. Allergen/ozone exposures started at 1 month and ICS at 3 months of age. At 6 months of age, methacholine-induced changes in luminal area of airways in proximal and distal lung slices were determined using videomicrometry, followed by histology of the same slices. Proximal airway responsiveness was increased by allergen/ozone and by ICS. Eosinophil profiles were increased by allergen/ozone in both proximal and distal airways, an effect that was decreased by ICS in distal airways. In both allergen/ozone- and air-exposed monkeys, ICS increased the number of alveolar attachments in distal airways, decreased mucin in proximal airways and decreased epithelial volume in both airways. ICS increased smooth muscle in air-exposed animals while decreasing it in allergen/ozone-exposed animals in both airways. In proximal airways, there was a small but significant positive correlation between smooth muscle and airway responsiveness, as well as between alveolar attachments and responsiveness. ICS change morphology and function in normal airways as well as allergen/ozone-exposed airways, suggesting that they should be reserved for infants with active symptoms

  13. Block copolymer/DNA vaccination induces a strong allergen-specific local response in a mouse model of house dust mite asthma.

    Directory of Open Access Journals (Sweden)

    Camille Rolland-Debord

    Full Text Available BACKGROUND: Allergic asthma is caused by abnormal immunoreactivity against allergens such as house dust mites among which Dermatophagoides farinae (Der f is a common species. Currently, immunotherapy is based on allergen administration, which has variable effect from patient to patient and may cause serious side effects, principally the sustained risk of anaphylaxis. DNA vaccination is a promising approach by triggering a specific immune response with reduced allergenicity. OBJECTIVE: The aim of the study is to evaluate the effects of DNA immunization with Der f1 allergen specific DNA on allergic sensitization, inflammation and respiratory function in mice. METHODS: Mice were vaccinated 28 and 7 days before allergen exposure with a Der f1-encoding plasmid formulated with a block copolymer. Asthma was induced by skin sensitization followed by intra-nasal challenges with Der f extract. Total lung, broncho-alveolar lavage (BAL and spleen cells were analyzed by flow cytometry for their surface antigen and cytokine expression. Splenocytes and lung cell IFN-γ production by CD8+ cells in response to Der f CMH1-restricted peptides was assessed by ELISPOT. IgE, IgG1 and IgG2a were measured in serum by ELISA. Specific bronchial hyperresponsiveness was assessed by direct resistance measurements. RESULTS: Compared to animals vaccinated with an irrelevant plasmid, pVAX-Der f1 vaccination induced an increase of B cells in BAL, and an elevation of IL-10 and IFN-γ but also of IL-4, IL-13 and IL-17 producing CD4+ lymphocytes in lungs and of IL-4 and IL-5 in spleen. In response to CD8-restricted peptides an increase of IFN-γ was observed among lung cells. IgG2a levels non-specifically increased following block copolymer/DNA vaccination although IgE, IgG1 levels and airways resistances were not impacted. CONCLUSIONS & CLINICAL RELEVANCE: DNA vaccination using a plasmid coding for Der f1 formulated with the block copolymer 704 induces a specific immune response

  14. Age-dependent baseline values of faecal cortisol metabolites in the American mink (Neovison vison) under semi-natural housing conditions.

    Science.gov (United States)

    Rauch, E; Bergmann, S; Hagn, A; Meixensperger, J; Reese, S; Palme, R; Erhard, M H

    2014-06-01

    The welfare of an animal is ensured if it is able to fully satisfy its essential species-typical needs in all functional aspects of behaviour. In mink, stereotypies and apathy, internal and/or external injuries as well as increased susceptibility to disease have been known to occur as a result of chronic stress. The non-invasive method of analysing faecal cortisol metabolites (FCM) allows conclusions to be drawn about the stress level in the respective housing system. The objective of this study is to find out how the cortisol metabolites content in the faecal changes with increasing age of the mink under semi-natural housing conditions. Thus, 40 American mink (Neovison vison) were housed in two outdoor enclosures imitating natural conditions. Throughout the entire study (13th to 32nd week of life), faecal samples were collected to measure cortisol metabolites. No differences in FCM concentrations between the two outdoor enclosures were found. In the young mink lower, less fluctuating FCM levels were found than in older animals. After the first faecal collection in the 13th/14th week of life, the level of metabolites decreased slightly (p = 0.032; 17th/18th week). From the 22nd/23rd week onwards until the 30th/31st week, shortly before the animals were pelted, continuously increasing concentrations were then measured. Increasing FCM levels with advancing age of the animals are probably attributable to the onset of sexual maturity and/or the respective season. This has to be taken into account in future studies using this method for assessing welfare and when comparing different mink housing systems. PMID:24033508

  15. Anticipatory activity and stereotypical behaviour in American mink (Mustela vison) in three housing systems differing in the amount of enrichments

    NARCIS (Netherlands)

    Vinke, C.M.; Bos, van den R.; Spruijt, B.M.

    2004-01-01

    The present study aimed to measure anticipatory activity in farmed mink (Mustela vison) to study the effects of the presence of environmental enrichments in three housing systems differing in cage structure and in the amount of enrichments. In studies on laboratory rats, anticipatory activity is use

  16. Views of United States Physicians and Members of the American Medical Association House of Delegates on Physician-assisted Suicide.

    Science.gov (United States)

    Whitney, Simon N.; Brown, Byron W.; Brody, Howard; Alcser, Kirsten H.; Bachman, Jerald G.; Greely, Henry T.

    2001-01-01

    Ascertained the views of physicians and physician leaders toward legalization of physician-assisted suicide. Results indicated members of AMA House of Delegates strongly oppose physician-assisted suicide, but rank-and-file physicians show no consensus either for or against its legalization. Although the debate is adversarial, most physicians are…

  17. Correlates of the sex trade among African-American youth living in urban public housing: assessing the role of parental incarceration and parental substance use.

    Science.gov (United States)

    Nebbitt, Von; Tirmazi, Taqi M; Lombe, Margaret; Cryer-Coupet, Qiana; French, Shelby

    2014-04-01

    African-American youth are disproportionately affected by parental incarceration and the consequences of parental substance use. Many adapt to the loss of their parents to prison or drug addiction by engaging in sex-risk behavior, particularly the sex trade. These youth may engage in this risky behavior for a number of reasons. Although previous research has examined this issue, most of these studies have focused on runaway or street youth or youth in international settings. Empirical evidence on correlates of trading sex for money among urban African-American youth is practically missing. Using a sample of 192 African-American youth living in urban public housing, this paper attempts to rectify this gap in knowledge by assessing how individual and parental factors are related to the likelihood of a youth trading sex for money. The sample for this study reported a mean age of 19; 28 % reported having traded sex for money; 30 % had a father currently in prison; and 7 % reported having a mother currently in prison. Maternal incarceration and paternal substance use were associated with a higher likelihood of trading sex for money. Given the potential health risks associated with trading sex for money, understanding correlates of this behavior has important implications for the health of this vulnerable population of youth and urban health in general. PMID:24248621

  18. Measurement of nicotine in household dust

    International Nuclear Information System (INIS)

    An analytical method of measuring nicotine in house dust was optimized and associations among three secondhand smoking exposure markers were evaluated, i.e., nicotine concentrations of both house dust and indoor air, and the self-reported number of cigarettes smoked daily in a household. We obtained seven house dust samples from self-reported nonsmoking homes and 30 samples from smoking homes along with the information on indoor air nicotine concentrations and the number of cigarettes smoked daily from an asthma cohort study conducted by the Johns Hopkins Center for Childhood Asthma in the Urban Environment. House dust nicotine was analyzed by isotope dilution gas chromatography-mass spectrometry (GC/MS). Using our optimized method, the median concentration of nicotine in the dust of self-reported nonsmoking homes was 11.7 ng/mg while that of smoking homes was 43.4 ng/mg. We found a substantially positive association (r=0.67, P<0.0001) between house dust nicotine concentrations and the numbers of cigarettes smoked daily. Optimized analytical methods showed a feasibility to detect nicotine in house dust. Our results indicated that the measurement of nicotine in house dust can be used potentially as a marker of longer term SHS exposure

  19. The effect of disodium cromoglycate, budesonide, and cyclosporin A on interleukin-4, interleukin-5, and interleukin-13 secretions in Der p I-stimulated T cells from house dust mite-sensitive atopic and nonatopic individuals.

    Science.gov (United States)

    Oh, Jae-Won; Lee, Ha-Baik; Chung, Yong-Hoon; Choi, Yong

    2002-01-01

    Disodium cromoglycate (DSCG), budesonide, and cyclosporin A (CsA) were the well-known immunomodulators for the allergic and immunologic diseases clinically. In this study, we evaluated the characteristics of inhibition on cytokine synthesis of Der p I-stimulated T cells by the same inhibiting concentrations of DSCG, budesonide, and CsA in house-dust mite antigen (Der p I)-specific atopic and nonatopic healthy individuals. Seven house dust mite allergen specific patients were recruited for this study. Seven healthy volunteers were included on the basis of negative allergic manifestations and low serum immunoglobulin E values. Peripheral blood mononuclear cells (PBMCs) were cultured in the presence of recombinant interleukin (rIL)-2 with or without budesonide, DSCG, CsA, and Der p I for 48 hours. Cells were stained with anti-CD4 fluorescein isothiocyanate-conjugated monoclonal antibody, and then anti-human IL-4 phycoerythrin, IL-5, or IL-13 monoclonal antibody, respectively, was added to both blocked and stained samples. Incubation of PBMC from atopics with each immunomodulator and Der p I resulted in the reduction of IL-4 secretion compared with Der p I alone stimulation. However, IL-4 secretion in PBMC from nonatopics was not reduced with DSCG and Der p I stimulation. IL-4, IL-5, and IL-13 secretions of PBMC from atopics were significantly decreased after incubation with each immunomodulator and Der p I, compared with after incubation with Der p I alone. These results might be considered to show either that DSCG has a selective inhibiting effect on cytokine production in T cells from atopics or is a weak inhibitor of cytokine secretions compared with budesonide and CsA at even strength for the inhibition of lymphocyte proliferation in normal, healthy individuals. PMID:12001789

  20. Is There a Free-Market Economist in the House? The Policy Views of American Economic Association Members

    OpenAIRE

    Klein, Daniel B.; Stern, Charlotta

    2006-01-01

    People often suppose or imply that free-market economists constitute a significant portion of all economists. We surveyed American Economic Association members and asked their views on 18 specific forms of government activism. We find that about 8 percent of AEA members can be considered supporters of free-market principles, and that less than 3 percent may be called strong supporters. The data is broken down by voting behavior (Democratic or Republican). Even the average Republican AEA membe...

  1. Housing and Demographic Risk Factors Impacting Foot and Musculoskeletal Health in African Elephants [Loxodonta africana] and Asian Elephants [Elephas maximus] in North American Zoos

    Science.gov (United States)

    Miller, Michele A.; Hogan, Jennifer N.; Meehan, Cheryl L.

    2016-01-01

    For more than three decades, foot and musculoskeletal conditions have been documented among both Asian [Elephas maximus] and African [Loxodonta africana] elephants in zoos. Although environmental factors have been hypothesized to play a contributing role in the development of foot and musculoskeletal pathology, there is a paucity of evidence-based research assessing risk. We investigated the associations between foot and musculoskeletal health conditions with demographic characteristics, space, flooring, exercise, enrichment, and body condition for elephants housed in North American zoos during 2012. Clinical examinations and medical records were used to assess health indicators and provide scores to quantitate conditions. Using multivariable regression models, associations were found between foot health and age [P value = 0.076; Odds Ratio = 1.018], time spent on hard substrates [P value = 0.022; Odds Ratio = 1.014], space experienced during the night [P value = 0.041; Odds Ratio = 1.008], and percent of time spent in indoor/outdoor exhibits during the day [P value welfare through better foot and musculoskeletal health. PMID:27415763

  2. Improved poultry house

    Energy Technology Data Exchange (ETDEWEB)

    None

    1983-01-01

    The relationship of energy and poultry production was explored in three areas: methane production from litter, broiler house insulation, and broiler house HVAC systems. The findings show that while a methane plant would not be popular with individual American poultry producers; the pay back in fuel and fertilizer, if the plant was located in close proximinity to the processing plant, would be favorable. Broiler house insulation has been dramatically improved since the outset of this study. Presently, all new installations in the survey area are the Environmental houses which are fully insulated. HVAC systems have had to keep pace with the introduction of better insulation. The new Environmental houses HVAC systems are fully automated and operating on a positive atmosphere principal. Ammonia and other problems have been kept in check while reducing air changes per house from a high of 7 per hour to as little as 3 per hour.

  3. 美国联邦政府与种族居住隔离问题的探讨%An Investigation into the Issues of Racial Housing Segregation in Contemporary American Society

    Institute of Scientific and Technical Information of China (English)

    韩玲

    2013-01-01

    通过分析美国联邦政府在实施公平住房政策中的做法和表现,指出联邦政府对当代美国社会依然盛行的种族居住隔离现状负有一定责任,并且在其消除种族居住隔离的实践中,也存在其它制约性因素。%The operation at the early period and activities during the enforcement of Fair Housing Policy indicate that the Federal Government is partly responsible for the present situation of racial housing segregation in contemporary American society.However, there are certain restrictive factors in its efforts to eliminate racial housing segregation .

  4. 75 FR 66977 - Housing Trust Fund

    Science.gov (United States)

    2010-10-29

    ... rule published on December 4, 2009 (74 FR 63938). The allocation formula will be renumbered and...., administrative requirements; monitoring, site and neighborhood standards; and affirmative marketing). This... affordable multifamily rental housing. Income Targeting Based on tabulations of American Housing Survey...

  5. Housing culture

    DEFF Research Database (Denmark)

    Roesdahl, Else; Scholkmann, Barbara

    On houses and their furniture and fittings, and on the study of this - with a comparison of rural, urban, monastic and aristocratic housing, and a special section on heating technologies.......On houses and their furniture and fittings, and on the study of this - with a comparison of rural, urban, monastic and aristocratic housing, and a special section on heating technologies....

  6. Allergies, asthma, and dust

    Science.gov (United States)

    Allergic rhinitis - dust ... make allergies or asthma worse are called triggers. Dust is a common trigger. When your asthma or allergies become worse due to dust, you are said to have a dust allergy. ...

  7. An Empirical Investigation of Housing Investment under Uncertainty

    OpenAIRE

    Downing, Chris; Wallace, Nancy

    2007-01-01

    In this paper, we focus on the response of housing investment to uncertainty in housing returns and interest rates. At the aggregate level, we regress quarterly housing starts on the levels and rolling standard deviations of housing returns and Treasury bill rates. We find that housing starts decline with higher volatility in either of these stated variables. We further explore these results using data on individuals from the American Housing Survey. We estimate the probability of observing m...

  8. House/ball culture and adolescent African-American transgender persons and men who have sex with men: a synthesis of the literature.

    Science.gov (United States)

    Phillips, Gregory; Peterson, James; Binson, Diane; Hidalgo, Julia; Magnus, Manya

    2011-04-01

    Transgender persons and young men of color who have sex with men (YMSM of color) have been severely affected by HIV in the USA. Houses and balls in the USA have historically been a primary meeting ground for YMSM of color and transgender people, offering an opportunity for HIV prevention activities. Houses provide a familial structure for YMSM of color and transgender people, while balls provide them with events at which they can congregate for social support and entertainment. A comprehensive literature search was conducted using Scopus and PubMed, Internet websites, and HIV prevention and care resources for YMSM of color associated with a multisite evaluation. Houses and balls have been responsive to the HIV/AIDS epidemic and have developing networks that are critical in providing a social and familiar context for often-disenfranchised youth. The organizations have embraced the need for HIV prevention, and their methodology may be transferable to other prevention contexts. Future studies are needed to identify culturally appropriate and effective methods of integration of house/ball methods into HIV prevention services aimed at transgender persons and YMSM of color. PMID:21271403

  9. Treg细胞在儿童过敏性哮喘SIT治疗过程中的变化%Change of treg cells during house dust mites specific immunotherapy for children with allergic asthma

    Institute of Scientific and Technical Information of China (English)

    朱俊民; 李付广

    2013-01-01

    Objective The aim of this study is to observe house dust mite (HDM) allergic children with asthma allergen-specific immunotherapy (SIT) in peripheral blood CD4+CD25+CD127-Tcells accounted for the percentage of CD4+T cells changes and their role in the SIT treatment, preliminary study of children with allergic asthma SIT mechanism, so as to provide new ideas for the prevention and treatment of asthma. Methods First Affiliated Hospital of Zhengzhou University pediatric clinic 48 cases of children with allergic asthma patients divided into two groups, one group for standardization SIT 1.5~2 years later, the two groups were collected peripheral blood. Each flow cytometry specimens CD4+CD25+CD127-T cells accounted for the percentage of CD4+Tcells, the results were statistically analyzed using statistical software. Results CD4+CD25+CD127-Tcells accounted for the percentage of CD4+T cells in HDM-SIT group was significantly higher. Conclusion The present study further confirmed SIT asthma treatment is effective;in HDM-SIT groupCD4+CD25+CD127-Tcells accounted for the percentage of CD4+Tcells increasedCD4+CD25+CD127-Tcells, suggesting that CD4+CD25+CD127-T cells may be specifically allergic asthma in children immunotherapy plays an important role.%目的:本研究通过观察对室尘螨(HDM)过敏的儿童哮喘患者,过敏原特异性免疫治疗(allergen specific immunotherapy, SIT)后外周血CD4+CD25+CD127-Treg细胞(regulatory T cell, Treg)细胞)占CD4+T cell的百分比的变化,以及它们在SIT治疗中的作用,初步探讨儿童过敏性哮喘SIT的机制,从而为哮喘的防治提供新思路。方法选取郑州大学第一附属医院儿科门诊48例儿童过敏性哮喘患者分两组,一组进行标准化SIT 1.5~2年后,采集两组患者的外周静脉血。用流式细胞仪检测每组标本中CD4+CD25+CD127-T细胞占CD4+T细胞的百分比,结果采用统计学软件进行统计学分析。结果CD4+CD25+CD127-T细胞占CD4+T

  10. Diez mitos que debilitan la política de vivienda en Latinoamerica/Ten Myths Undermining Latin American Housing Policy

    Directory of Open Access Journals (Sweden)

    Alan Gilbert

    2011-12-01

    Full Text Available La política de vivienda de Latinoamérica no puede considerarse como un gran éxito. Las cifras oficiales muestran que el déficit de vivienda está incrementando en la mayoría de países. Por su puesto, resolver el problema de la vivienda es un asunto difícil, y el rápido crecimiento urbano junto con los altos niveles de pobreza hacen que sea aún más complicado. Sin embargo, hay muchas fallas en la política de vivienda actual, y este artículo identifica diez mitos que han infiltrado el léxico de la política de vivienda. Este artículo es una invitación a los gobiernos de la región para que consideren si alguno de los mitos identificados, o todos, aún persisten dentro de sus propias políticas, y si estos mitos son tan nocivos como se sugiere en este artículo. Housing policy in Latin America cannot be regarded as having been a huge success. Official figures show that the housing deficit is rising in most countries. Of course, solving the housing problem is difficult and complicated further by rapid urban growth and too much poverty. Nonetheless, there are many failings in current housing policy and the current paper identifies ten myths that have infiltrated the housing policy lexicon. This paper is an invitation to the region's governments to consider whether any or all of the identified myths persist within their own policies and whether those myths are as damaging as will be suggested here.

  11. Dust pollution solutions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-09-15

    Cimbria Moduflex is a leading manufacturer of dust-free loading chutes and accessories to the bulk handling industry. The Moduflex chute of modular construction can precisely match customer needs. Dust Control Technology recently launched its DustBoss DB-45 which controls airborne particles and surface dust with low water usage. DustScan Ltd., provides a range of equipment for nuisance and PM10 dust monitoring. Donaldson Torit supplies the Torit PowerCore dust collector. 1 photo.

  12. Clay Houses

    Science.gov (United States)

    Pedro, Cathy

    2011-01-01

    In this article, the author describes a project designed for fourth-graders that involves making clay relief sculptures of houses. Knowing the clay houses will become a family heirloom makes this lesson even more worth the time. It takes three classes to plan and form the clay, and another two to underglaze and glaze the final products.

  13. DOES THE OVERALL QUALITY IN THE SUPPLY OF AN URBAN BUS SERVICE AFFECT HOUSE PRICES? - A NORTH-AMERICAN CASE STUDY

    OpenAIRE

    F. Des Rosiers; Dubé, J.; M. Thériault; Voisin, M.

    2006-01-01

    This study aims at testing whether, and to what extent, the overall quality in the supply of an urban bus service translates into higher house values for properties located along the lines. Located 150 miles east of Montreal, Quebec City, with a population of roughly 560 000 (750 000 for the Quebec Metropolitan Area - QMA), is used as a case study. Operated under the RÈseau de Transport de la Capitale (RTC)1, Quebec Cityís bus network is composed of three types of routes:* In operation eighte...

  14. "It’s like Big Mama’s house": Examining Extended Family Influences on the Dietary Behaviors of African American Children

    OpenAIRE

    Brown, Natasha A.; Thornton, Rachel L. J.; Smith, Katherine Clegg; Surkan, Pamela J.; Levine, David M.

    2014-01-01

    The family environment plays an important role in influencing children’s dietary behaviors. Traditionally, African American extended family members play a key role in child socialization. We examine the role of extended families in how children are socialized to adopt dietary norms. We conducted in-depth, semi-structured interviews with 24 individuals across eight family units to elicit information regarding the influences of culture and families on children’s dietary behaviors. Findings sugg...

  15. Correlates of the Sex Trade among African–American Youth Living in Urban Public Housing: Assessing the Role of Parental Incarceration and Parental Substance Use

    OpenAIRE

    Nebbitt, Von; Tirmazi, Taqi M.; Lombe, Margaret; Cryer-Coupet, Qiana; French, Shelby

    2013-01-01

    African–American youth are disproportionately affected by parental incarceration and the consequences of parental substance use. Many adapt to the loss of their parents to prison or drug addiction by engaging in sex-risk behavior, particularly the sex trade. These youth may engage in this risky behavior for a number of reasons. Although previous research has examined this issue, most of these studies have focused on runaway or street youth or youth in international settings. Empirical evidenc...

  16. CDBG Housing Activity

    Data.gov (United States)

    Department of Housing and Urban Development — CDBG activity related to housing, including multifamily rehab, housing services, code enforcement, operation and repair of foreclosed property and public housing...

  17. Inactivation of dust mites, dust mite allergen, and mold from carpet.

    Science.gov (United States)

    Ong, Kee-Hean; Lewis, Roger D; Dixit, Anupma; MacDonald, Maureen; Yang, Mingan; Qian, Zhengmin

    2014-01-01

    Carpet is known to be a reservoir for biological contaminants, such as dust mites, dust mite allergen, and mold, if it is not kept clean. The accumulation of these contaminants in carpet might trigger allergies or asthma symptoms in both children and adults. The purpose of this study is to compare methods for removal of dust mites, dust mite allergens, and mold from carpet. Carpets were artificially worn to simulate 1 to 2 years of wear in a four-person household. The worn carpets were inoculated together with a common indoor mold (Cladosporium species) and house dust mites and incubated for 6 weeks to allow time for dust mite growth on the carpet. The carpets were randomly assigned to one of the four treatment groups. Available treatment regimens for controlling carpet contaminants were evaluated through a literature review and experimentation. Four moderately low-hazard, nondestructive methods were selected as treatments: vacuuming, steam-vapor, Neem oil (a natural tree extract), and benzalkonium chloride (a quaternary ammonium compound). Steam vapor treatment demonstrated the greatest dust mite population reduction (p 0.05) for both physical and chemical methods. The steam-vapor treatment effectively killed dust mites and denatured dust mite allergen in the laboratory environment. PMID:24467247

  18. The Missing Link in Housing Sector Reforms in Nigeria

    OpenAIRE

    Akintunde Otubu

    2012-01-01

    Housing is a fundamental product for every human being irrespective of financial standing. World acclaimed American psychologist, Abraham Maslow ranked shelter as second only to food in his hierarchy of human needs. Despite the importance of housing to the socio-economic development of man and the nation, housing problems have remained endemic throughout the world. In today’s world, some 100 million persons are homeless and more than a billion are inadequately housed. In 2002 housing deficit...

  19. Conformal house

    DEFF Research Database (Denmark)

    Ryttov, Thomas Aaby; Sannino, Francesco

    2010-01-01

    fixed point. As a consistency check we recover the previously investigated bounds of the conformal windows when restricting to a single matter representation. The earlier conformal windows can be imagined to be part now of the new conformal house. We predict the nonperturbative anomalous dimensions at...... the infrared fixed points. We further investigate the effects of adding mass terms to the condensates on the conformal house chiral dynamics and construct the simplest instanton induced effective Lagrangian terms...

  20. Housing Market and Housing Investment (Japanese)

    OpenAIRE

    UNAYAMA Takashi

    2015-01-01

    This paper aims to explain why housing investment in Japan stagnated in the 2000s. Housing investment consists of two parts: replacement and a net increase of housing stock, which can be further decomposed into changes in the number of households and the housing utilization rate. Using the Housing and Land Survey, it is shown that all of the following factors caused the decrease in housing investment: house replacement decreased due to an increasing share of non-wooden houses and collective h...

  1. The Keys to the White House

    Science.gov (United States)

    Lichtman, Allan J.

    2012-01-01

    The Keys to the White House is a historically-based system for predicting the result of the popular vote in American presidential elections. The Keys system tracks the big picture of how well the party holding the White House has governed and does not shift with events of the campaign. This model gives specificity to the idea that it is…

  2. Saharan dust storms: nature and consequences

    Science.gov (United States)

    Goudie, A. S.; Middleton, N. J.

    2001-12-01

    This paper reviews recent work on the role of Saharan dust in environmental change, the location and strength of source areas, the transport paths of material away from the desert, the rates of Saharan dust deposition, the nature of that material (including PeriSaharan loess) and the changing rates of dust activity in response to long and short-term climatic changes. The Sahara produces more aeolian soil dust than any other world desert, and Saharan dust has an important impact on climatic processes, nutrient cycles, soil formation and sediment cycles. These influences spread far beyond Africa, thanks to the great distances over which Saharan dust is transported. The precise locations of Saharan dust source areas are not well known, but data from the Total Ozone Mapping Spectrometer (TOMS) suggest two major source areas: the Bodélé depression and an area covering eastern Mauritania, western Mali and southern Algeria. Trajectories of long-distance transport are relatively well documented, but the links between source areas and seasonal Saharan dust pathways are not. However, it is possible that Harmattan dust from the Bodélé depression may not be the source of the prominent winter plume over the tropical North Atlantic, as is often suggested in the literature. Few of the data on particle size characteristics of Saharan dust are derived from major source areas or from Africa itself. Saharan dusts sampled from the Harmattan plume and over Europe are dominated by SiO 2 and Al 2O 3, a characteristic they share with North American and Chinese dusts. The concentrations of these two major elements are similar to those found in world rocks. PeriSaharan loess is conspicuous by its relative absence, considering the Sahara's dominance of the global desert dust cycle both in the contemporary era and through the geological past. In recent decades, the frequency of Saharan dust events has varied markedly in response to climatic factors such as drought and anthropogenic

  3. Endotoxin concentration in poultry houses for laying hens kept in cages or in alternative housing systems

    OpenAIRE

    Huneau-Salaün, Adeline; Le Bouquin, Sophie; Bex-Capelle, Valérie; Huonnic, Didier; Balaine, Loïc; Guillam, Marie-Thérèse; Squizani, Fabrice; Ségala, Claire; Michel, Virginie

    2011-01-01

    Abstract 1. Endotoxins as components of organic dust may have adverse effects on the respiratory health of workers in poultry buildings. The move towards more welfare-friendly housing systems for layers may increase worker exposure to air contaminants due to the use of litter. 2. The endotoxin concentrations in the inhalable fraction of airborne dust (below 100 ?m) from cage and alternative system henhouses (on-floor, free range and aviaries) were compared under both experiment...

  4. Toxicity of lunar dust

    OpenAIRE

    Linnarsson, Dag; Carpenter, James; Fubini, Bice; Gerde, Per; Karlsson, Lars L.; Loftus, David J.; Prisk, G. Kim; Staufer, Urs; Tranfield, Erin M.; van Westrenen, Wim

    2012-01-01

    The formation, composition and physical properties of lunar dust are incompletely characterised with regard to human health. While the physical and chemical determinants of dust toxicity for materials such as asbestos, quartz, volcanic ashes and urban particulate matter have been the focus of substantial research efforts, lunar dust properties, and therefore lunar dust toxicity may differ substantially. In this contribution, past and ongoing work on dust toxicity is reviewed, and major knowle...

  5. Dust particle dynamics in atmospheric dust devils

    Science.gov (United States)

    Izvekova, Yulia; Popel, Sergey

    2016-04-01

    Dust particle dynamics is modeled in the Dust Devils (DDs). DD is a strong, well-formed, and relatively long-lived whirlwind, ranging from small (half a meter wide and a few meters tall) to large (more than 100 meters wide and more than 1000 meters tall) in Earth's atmosphere. We develop methods for the description of dust particle charging in DDs, discuss the ionization processes in DDs, and model charged dust particle motion. Our conclusions are consistent with the fact that DD can lift a big amount of dust from the surface of a planet into its atmosphere. On the basis of the model we perform calculations and show that DDs are important mechanism for dust uplift in the atmospheres of Earth and Mars. Influence of DD electric field on dynamics of dust particles is investigated. It is shown that influence of the electric field on dust particles trajectories is significant near the ground. At some altitude (more then a quarter of the height of DD) influence of the electric field on dust particles trajectories is negligible. For the calculation of the dynamics of dust electric field can be approximated by effective dipole located at a half of the height of DD. This work was supported by the Russian Federation Presidential Program for State Support of Young Scientists (project no. MK-6935.2015.2).

  6. Active house

    DEFF Research Database (Denmark)

    Eriksen, Kurt Emil; Olesen, Gitte Gylling Hammershøj

    2010-01-01

    Formålet med dette abstrakt er at illustrere, at huse kan være konstrueret til at basere sig udelukkende på vedvarende energikilder og samtidig være CO2-neutrale og producere mere energi end de forbruger. Active House Visionen undersøger disse muligheder i otte demonstration huse i fem forskellige...

  7. House Slaves

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Rising house prices in China’s major cities is a major headache for people taking a first step on the property ladder and has led to a growing number sacrificing quality of life just to have a home of their own Closely watching the family’s spend- ing a

  8. Polybrominated diphenyl ethers (PBDEs) in indoor dust and human hair

    Science.gov (United States)

    Kang, Yuan; Wang, Hong Sheng; Cheung, Kwai Chung; Wong, Ming Hung

    2011-05-01

    In the present study, settled workplace dust ( n = 55) from commercial offices, secondary schools, shopping malls, hospitals, electronic factories and manufacturing plants in Hong Kong and settled home dust ( n = 23) from Hong Kong, Shenzhen and Guangzhou, around the Pearl River Delta were collected. Chemical analyses showed that the total PBDEs in workplace dust ranged from 397 to 40,236 ng g -1, with the dust samples from electronic factories having the highest levels (2122-40,236 ng g -1), and dust from homes ranging from 685 to 18,385 ng g -1. The most abundant BDE congeners found were BDE-209 in both workplace dust and home dust, followed by BDE-99 and BDE-47. No significant correlations were observed between total PBDE concentrations in home dust and the age or the house ( p > 0.05), concentrations of BDE-99 + BDE-47 and the number of furniture containing foam ( p > 0.05), and concentrations of BDE-209 and the number of electronic appliances ( p > 0.05). BDE-47, -99, -100 and -183 were found in most of the hair samples collected from occupants of these homes with BDE-47 being the dominant congener (0.86-5.24 ng g -1). The BDE-183 concentration in home dust was significantly correlated with that in human hair ( r = 0.55, p children via non-dietary ingestion of dust (101-404 ng day -1) was higher than that via food consumption (77-190 ng day -1).

  9. Smart Houses

    Science.gov (United States)

    1987-01-01

    GWS takes plans for a new home and subjects them to intensive computerized analysis that does 10,000 calculations relative to expected heat loss and heat gain, then provides specifications designed specifically for each structure as to heating, cooling, ventilation and insulation. As construction progresses, GWS inspects the work of the electrical, plumbing and insulation contractors and installs its own Smart House Radiant Barrier. On completion of the home, GWS technicians use a machine that creates a vacuum in the house and enables computer calculation of the air exchanged, a measure of energy efficiency. Key factor is the radiant barrier, borrowed from the Apollo program. This is an adaptation of a highly effective aluminized heat shield as a radiation barrier holding in or keeping out heat, cold air and water vapor.

  10. Housing Gap

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Measures to cool down China's red-hot housing market are sweeping the country. The State Council, China's cabinet, issued a circular in late May announcing an increase in the minimum down payment for a new apartment larger than 90 square meters to 30 percent from 20 percent and imposing a transaction tax on properties resold within five years of purchase, among others. One of the aims, according to the cir-

  11. On Dust Charging Equation

    OpenAIRE

    Tsintsadze, Nodar L.; Tsintsadze, Levan N.

    2008-01-01

    A general derivation of the charging equation of a dust grain is presented, and indicated where and when it can be used. A problem of linear fluctuations of charges on the surface of the dust grain is discussed.

  12. Dust-off

    OpenAIRE

    Maycroft, Neil; Cheang, Shu Lea

    2015-01-01

    The fan of a motherboard switches on and off intermittently. It blows household dust, removed from the inside of a computer carcass, into the air. The dust then settles onto the motherboard, to be blown off again. This continual movement of dust is contained in the piece. However, it should remind us that the ceaseless creation and motion of unconfined dust accompanies all stages of the e-waste journey.

  13. Physics of interstellar dust

    CERN Document Server

    Krugel, Endrik

    2002-01-01

    The dielectric permeability; How to evaluate grain cross sections; Very small and very big particles; Case studies of Mie calculus; Particle statistics; The radiative transition probability; Structure and composition of dust; Dust radiation; Dust and its environment; Polarization; Grain alignment; PAHs and spectral features of dust; Radiative transport; Diffuse matter in the Milky Way; Stars and their formation; Emission from young stars. Appendices Mathematical formulae; List of symbols.

  14. Pair Housing of Macaques in Research Facilities: A Science-Based Review of Benefits and Risks

    OpenAIRE

    DiVincenti, Louis; Wyatt, Jeffrey D

    2011-01-01

    Despite the enactment in the early 1990s of regulations requiring social housing of nonhuman primates (NHP), single housing is still prevalent in American research facilities. The publication of the 2011 edition of The Guide for the Care and Use of Laboratory Animals has increased emphasis on the implementation of social housing as the default housing method for NHP. Overestimation of the risks inherent in social housing coupled with underestimation of both the benefits of social housing and ...

  15. Dusts and Molds

    Science.gov (United States)

    ... ABOUT DUSTS AND MOLDS? Tiny dust particles and mold spores can be inhaled into the lungs. Dusts that come from a living source (“organic dusts”) such as hair, bedding, hay, grain, silage, and dried urine and feces are most dangerous. ...

  16. Green Housing

    OpenAIRE

    Johnson Eriksson, Christian

    2014-01-01

    The Building is a combination of a green house and multi familyhousing building. The building´s courtyard is transformed in to a winter garden and creates an climate controlled environment with exotic vegitation blooming all year around. The courtyard is working as an extra livingroom with nice public walks in different levels were people can relax, exercise and socialise. The heat generated from the winter garden can be reused and recycled in to the floor slabs. It can also be deposited into...

  17. Exposure to tobacco dust in primary tobacco-processing workers

    International Nuclear Information System (INIS)

    Numerous workers are engaged in processing of tobacco in Iran and therefore, their exposures to tobacco dust are likely to be high. The aim of this study was to evaluate the workers' exposure to tobacco dust. Total dusts were collected within the workers' breathing zone using a Personal Air Sampler (PAS) and respirable dusts were measured using a real time monitor (Micro Dust Pro) with a particle size adapter in different parts of the factory. To weigh the filters a microbalance accurate to 5 decimal places was used. The mean total tobacco dust concentrations for personal exposure near breathing zone in this study was 9.32 mgm-3 that was lower than TLV recommended by American Conference of Governmental Industrial Hygienists (ACGIH). In contrast the mean respirable dust concentrations was 3.28 mgm-3 which is higher than Threshold Limit Value (TLV). Dust control methods such as good maintenance of existent dust emission control systems, insulation of dust sources and designing suitable local exhaust ventilation should be applied to maintain workers' health. (author)

  18. Partners in Housing: Virginia's Nonprofit Housing Sector

    OpenAIRE

    Koebel, C. Theodore; Hardin, Brooke, D.

    1999-01-01

    Nonprofit housing organizations primarily exist to address the housing needs of low-income Virginians. This survey, conducted in 1998 through the leadership of VHDA, revealed a nonprofit housing sector that is maturing into an important component of housing markets throughout the state.

  19. 76 FR 46832 - Notice of Submission of Proposed Information Collection to OMB; Assessment of Native American...

    Science.gov (United States)

    2011-08-03

    ... American, Alaska Native, and Native Hawaiian Housing Needs AGENCY: Office of the Chief Information Officer... American, Alaska Native, and Native Hawaiian populations with respect to both their housing conditions and... similar assessment in 1996, prior to the passage of the Native American Housing Assistance and...

  20. Toxicity of lunar dust

    CERN Document Server

    Linnarsson, Dag; Fubini, Bice; Gerde, Per; Karlsson, Lars L; Loftus, David J; Prisk, G Kim; Staufer, Urs; Tranfield, Erin M; van Westrenen, Wim

    2012-01-01

    The formation, composition and physical properties of lunar dust are incompletely characterised with regard to human health. While the physical and chemical determinants of dust toxicity for materials such as asbestos, quartz, volcanic ashes and urban particulate matter have been the focus of substantial research efforts, lunar dust properties, and therefore lunar dust toxicity may differ substantially. In this contribution, past and ongoing work on dust toxicity is reviewed, and major knowledge gaps that prevent an accurate assessment of lunar dust toxicity are identified. Finally, a range of studies using ground-based, low-gravity, and in situ measurements is recommended to address the identified knowledge gaps. Because none of the curated lunar samples exist in a pristine state that preserves the surface reactive chemical aspects thought to be present on the lunar surface, studies using this material carry with them considerable uncertainty in terms of fidelity. As a consequence, in situ data on lunar dust...

  1. Laboratory study of PCB transport from primary sources to settled dust

    Science.gov (United States)

    Transport of house dust and Arizona Test Dust on polychlorinated biphenyl (PCB)-containing panels and PCB-free panels was investigated in a 30-m3 stainless steel chamber. The PCB-containing panels were aluminum sheets coated with a PCB-spiked, oil-based primer or two-part polysul...

  2. Social Housing under Oligopoly

    OpenAIRE

    Usategui Díaz de Otalora, José María

    2008-01-01

    In this paper it is shown that the setting up of a social housing system may decrease the total number of houses built in the market, induce a price of non-social houses greater than the price of houses without that system and increase the profits of housing developers even in situations where they have to sell social houses at a price below production cost. The analysis considers a situation with imperfect competition in the housing market and with a social housing system where housing devel...

  3. Public housing accommodations for individuals with disabilities.

    Science.gov (United States)

    Little, Samuel B

    2002-01-01

    The federal Housing Act of 1962 as amended and the subsequent laws of accommodations insure that all groups within American society, including those with disabilities, have access to housing opportunities. In spite of the clear provisions of various laws of accommodations enacted after 1962, it is questionable whether disabled individuals are adequately served by resident programs operated by Public Housing Agencies (PHAs) because rates of poverty, unemployment, domestic violence, and suicide are much higher among people with disabilities than in the nondisabled population. There are approximately 5 million residents living in 2.5 public housing units nationwide. New York, Puerto Rico, Chicago, Philadelphia and Baltimore have the five largest PHAs in the country. In combination, they rent 320,000 of the 1,300,495 inventory of rental properties owned by the country's 3,400 PHAs. Elderly and disabled residents without children account for 43% of all public housing families in the country. PMID:12809381

  4. DUST FORMATION IN MACRONOVAE

    International Nuclear Information System (INIS)

    We examine dust formation in macronovae (as known as kilonovae), which are the bright ejecta of neutron star binary mergers and one of the leading sites of r-process nucleosynthesis. In light of information about the first macronova candidate associated with GRB 130603B, we find that dust grains of r-process elements have difficulty forming because of the low number density of the r-process atoms, while carbon or elements lighter than iron can condense into dust if they are abundant. Dust grains absorb emission from ejecta with an opacity even greater than that of the r-process elements, and re-emit photons at infrared wavelengths. Such dust emission can potentially account for macronovae without r-process nucleosynthesis as an alternative model. This dust scenario predicts a spectrum with fewer features than the r-process model and day-scale optical-to-ultraviolet emission

  5. Positive response of Indian summer rainfall to Middle East dust

    KAUST Repository

    Jin, Qinjian

    2014-06-02

    Using observational and reanalyses data, we investigated the impact of dust aerosols over the Middle East and the Arabian Sea (AS) on the Indian summer monsoon (ISM) rainfall. Satellite and aerosol reanalysis data show extremely heavy aerosol loading, mainly mineral dust, over the Middle East and AS during the ISM season. Multivariate empirical orthogonal function analyses suggest an aerosol-monsoon connection. This connection may be attributed to dust-induced atmospheric heating centered over the Iranian Plateau (IP), which enhances the meridional thermal contrast and strengthens the ISM circulation and rainfall. The enhanced circulation further transports more dust to the AS and IP, heating the atmosphere (positive feedback). The aerosols over the AS and the Arabian Peninsula have a significant correlation with rainfall over central and eastern India about 2 weeks later. This finding highlights the nonlocal radiative effect of dust on the ISM circulation and rainfall and may improve ISM rainfall forecasts. © 2014. American Geophysical Union. All Rights Reserved.

  6. Operational Dust Prediction

    Science.gov (United States)

    Benedetti, Angela; Baldasano, Jose M.; Basart, Sara; Benincasa, Francesco; Boucher, Olivier; Brooks, Malcolm E.; Chen, Jen-Ping; Colarco, Peter R.; Gong, Sunlin; Huneeus, Nicolas; Jones, Luke; Lu, Sarah; Menut, Laurent; Morcrette, Jean-Jacques; Mulcahy, Jane; Nickovic, Slobodan; Garcia-Pando, Carlos P.; Reid, Jeffrey S.; Sekiyama, Thomas T.; Tanaka, Taichu Y.; Terradellas, Enric; Westphal, Douglas L.; Zhang, Xiao-Ye; Zhou, Chun-Hong

    2014-01-01

    Over the last few years, numerical prediction of dust aerosol concentration has become prominent at several research and operational weather centres due to growing interest from diverse stakeholders, such as solar energy plant managers, health professionals, aviation and military authorities and policymakers. Dust prediction in numerical weather prediction-type models faces a number of challenges owing to the complexity of the system. At the centre of the problem is the vast range of scales required to fully account for all of the physical processes related to dust. Another limiting factor is the paucity of suitable dust observations available for model, evaluation and assimilation. This chapter discusses in detail numerical prediction of dust with examples from systems that are currently providing dust forecasts in near real-time or are part of international efforts to establish daily provision of dust forecasts based on multi-model ensembles. The various models are introduced and described along with an overview on the importance of dust prediction activities and a historical perspective. Assimilation and evaluation aspects in dust prediction are also discussed.

  7. Dust Devil Tracks

    Science.gov (United States)

    2002-01-01

    (Released 8 May 2002) The Science This image, centered near 50.0 S and 17.7 W displays dust devil tracks on the surface. Most of the lighter portions of the image likely have a thin veneer of dust settled on the surface. As a dust devil passes over the surface, it acts as a vacuum and picks up the dust, leaving the darker substrate exposed. In this image there is a general trend of many of the tracks running from east to west or west to east, indicating the general wind direction. There is often no general trend present in dust devil tracks seen in other images. The track patterns are quite ephemeral and can completely change or even disappear over the course of a few months. Dust devils are one of the mechanisms that Mars uses to constantly pump dust into the ubiquitously dusty atmosphere. This atmospheric dust is one of the main driving forces of the present Martian climate. The Story Vrrrrooooooooom. Think of a tornado, the cartoon Tasmanian devil, or any number of vacuum commercials that powerfully suck up swirls of dust and dirt. That's pretty much what it's like on the surface of Mars a lot of the time. Whirlpools of wind called

  8. Test of dust scattering caused by dumpling of concrete materials

    International Nuclear Information System (INIS)

    The behaviors of dust at the disposal of low-level radioactive concrete waste were investigated for making an estimation of exposure dose of the workers who inhale a contaminated dust in the air. Dust concentration and it's particle size in the air caused by the dumping test of mock concrete materials were measured. The concrete dusts scatter usually by grinding, cutting, and blasting of a lump of concrete. Three test concrete samples of different sizes, such as particulate (crushed stone), broken concrete (small pieces of about 5 mm - 20 cm), and broken concrete (large pieces of about 30 cm) were used in the dumping test. Concentrations of suspended and respirable dust (< 10 μm) in the air were measured by digital aerosol monitors and dust samplers which were located at 4 - 10 m distant from a dropping center. A testing house was built for avoiding from the effects of environment, such as wind direction and wind velocity. The test samples were dropped on the surface of steel plate from about 1 meter height at a low and a high wind condition. In case of the particulate test sample, the dropping height and the wind velocity affected to the dust concentration in the air. The dust scattering was largely suppressed by the uses of water sprinkling, suppression sheet and wet test sample. (Suetake, M.)

  9. Social Housing in Denmark

    DEFF Research Database (Denmark)

    Vestergaard, Hedvig; Scanlon, Kath J

    2014-01-01

    Social housing is a cornerstone in the Danish welfare society and is accessible for all households. By law, social housing must be rented at cost rents, which are based on historical costs; rents do not respond to market forces. Social housing aims to provide good standard, secure and affordable...... housing for all. It especially addresses the housing needs of lower-income households as well as new house-holds. This chapter presents how the self-owning Danish non-profit housing associations construct and manage one fifth of the Danish housing stock. Here the tenants’ democracy sets the framework for...... measures as well as social initiatives in the existing stock....

  10. 76 FR 25703 - Notice of Proposed Information Collection for Public Comment on the Assessment of Native American...

    Science.gov (United States)

    2011-05-05

    ...; housing agency, homeless shelter, and social service agency staff. Group discussions: Native Americans... Native American, Alaska Native and Native Hawaiian Housing Needs AGENCY: Office of Policy Development and...: Title of Proposal: Assessment of Native American, Alaska Native and Native Hawaiian Housing...

  11. 24 CFR 982.609 - Congregate housing: Housing quality standards.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Congregate housing: Housing quality standards. 982.609 Section 982.609 Housing and Urban Development Regulations Relating to Housing and Urban... Types Congregate Housing § 982.609 Congregate housing: Housing quality standards. (a) HQS standards...

  12. Lunar Dust Mitigation Screens

    Science.gov (United States)

    Knutson, Shawn; Holloway, Nancy

    With plans for the United States to return to the moon, and establish a sustainable human presence on the lunar surface many issues must be successfully overcome. Lunar dust is one of a number of issues with the potential to create a myriad of problems if not adequately addressed. Samples of dust brought back from Apollo missions show it to be soft, yet sharp and abrasive. The dust consists of a variety of morphologies including spherical, angular blocks, shards, and a number of irregular shapes. One of the main issues with lunar dust is its attraction to stick to anything it comes in contact with (i.e. astronauts, equipment, habitats, etc.). Ionized radiation from the sun strikes the moon's surface and creates an electrostatic charge on the dust. Further, the dust harbors van der Waals forces making it especially difficult to separate once it sticks to a surface. During the Apollo missions, it was discovered that trying to brush the lunar dust from spacesuits was not effective, and rubbing it caused degradation of the suit material. Further, when entering the lunar module after moonwalks, the astronauts noted that the dust was so prolific inside the cabin that they inhaled and ingested it, causing at least one of them, Harrison "Jack" Schmidt, to report irritation of the throat and lungs. It is speculated that the dust could also harm an astronaut's nervous and cardiovascular systems, especially during an extended stay. In addition to health issues, the dust can also cause problems by scouring reflective coatings off of thermal blankets, and roughening surfaces of windows and optics. Further, panels on solar cells and photovoltaics can also be compromised due to dust sticking on the surfaces. Lunar dust has the capacity to penetrate seals, interfere with connectors, as well as mechanisms on digging machines, all of which can lead to problems and failure. To address lunar dust issues, development of electrostatic screens to mitigate dust on sur-faces is currently

  13. A New Laboratory For Terahertz Characterization Of Cosmic Analog Dusts

    Science.gov (United States)

    Perera, Thushara; Liu, Lunjun; Breyer, Fiona; Schonert, Ryan; O'Shea, Kyle; Roesner, Rebecca

    2016-06-01

    Most studies conducted with observatories such as ALMA, SOFIA, PLANCK, and Herschel will benefit from knowledge of (1) the predominant cosmic dust species in various environments and (2) the mm/sub-mm optical properties of cosmic dusts, including the temperature dependent-emissivity and spectral index. We have undertaken two efforts to enable the laboratory study of cosmic analogs dusts in the frequency range 60-2000 GHz. They are: (1) the construction of a novel compact Fourier Transform Spectrometer (FTS) design coupled to a dry 4-K cryostat which houses a cooled sample exchanger (filter wheel) and a bolometer. (2) The production of Mg- and Fe-rich silicate dusts using sol-gel methods; various tests to determine their physical and chemical properties; embedding of samples in LDPE pellets for insertion into the novel FTS. This presentation will focus on the current status of the apparatus and data from its first few months of use.

  14. The Comfort Houses

    DEFF Research Database (Denmark)

    Larsen, Tine Steen; Jensen, Rasmus Lund; Daniels, Ole

    This report describes the results of the Comfort Houses measuring programme conducted by Aalborg University in the period 2008 to 2011. The results from the houses included in the project are examined in detail in 8 house-specific reports. All house-specific reports referred to in this report can...

  15. International house prices

    OpenAIRE

    Australian Treasury

    2003-01-01

    This article examines developments in house prices in a number of countries over recent years. It shows that while the magnitude of house price movements have differed across countries, the recent trend of rising prices in Australia has also been experienced in some other developed countries. This article also examines changes in housing affordability arising from changes in house prices, interest rates, housing debt and disposable income in the United Kingdom, Australia and the United States...

  16. Dust Storms: Why Are Dust Storms a Concern?

    Science.gov (United States)

    ... in Environmental Health, Chemistry, and Toxicology More Resources Dust Storms en español Why are dust storms a concern? A dust storm is a moving ... on Human Health (US Geological Survey) Chemicals in Dust Storms Are these chemicals in MY community? Particulate Matter ...

  17. Radioactive dust sampling

    International Nuclear Information System (INIS)

    This technical report is the second of a five part series on the technical evaluation of a number of dust monitoring instruments and the characterization of Long-Lived Radioactive Dust (LLRD). The data reported here pertain to an experimental study conducted under laboratory controlled conditions in a Long-Lived Radioactive Dust Test Facility (LLRDTF) designed for this purpose. This study was carried out with a twofold purpose in mind, namely, for the characterization of dust and LLRD, and for the evaluation of a variety of monitoring instruments, including cascade impactors, optical particle counters, nylon cyclones, open face filter samplers, and α-particle personal dosimeters, the latter normally used for α-particle radiation exposure purposes. Several non-radioactive and radioactive dusts were characterized. The non-radioactive dusts were SiC, Al2O3, talcum powder, corn starch and flour, while uranium tailings were used as a radioactive dust. Clear differences in instrument performance were observed for the various measurements made

  18. Dust torus around Mars

    Science.gov (United States)

    Juhasz, Antal; Horanyi, Mihaly

    1995-01-01

    We investigate the orbital dynamics of small dust particles generated via the continuous micrometeoroid bombardment of the Martian moons. In addition to Mar's oblateness, we also consider the radiation pressure perturbation that is complicated by the planet's eccentric orbit and tilted rotational axis. Considering the production rates and the lifetimes of dust grains, we show that particles from Deimos with radii of about 15 micrometers are expected to dominate the population of a permanently present and tilted dust torus. This torus has an estimated peak number density of approximately equals 5 x 10(exp -12)/cu cm and an optical depth of approximately equals 4 x 10(exp -8).

  19. Lead loadings in household dust in Delhi, India.

    Science.gov (United States)

    Kumar, A; Scott Clark, C

    2009-10-01

    Lead in household dust is dangerous to children who ingest lead from playing close to the ground, and having frequent hand-to-mouth contact. Although there have been several investigations of lead levels in India in air, blood and new paint, the literature is sparse on the levels of lead in household dust. This study analyzed 99 samples of dust taken from bare floors and 49 samples of dust taken from windowsills in a cross-section of Delhi, India houses for lead loadings. The arithmetic mean of lead loading for floor samples and windowsill dust samples was found to be 36.24 microg/ft(2) and 129.5 microg/ft(2), respectively. The geometric mean of dust lead loading for floor and interior windowsill samples was found to be 19.7 microg/ft(2) and 75.5 microg/ft(2), respectively. Comparing the results with US geometric mean dust lead levels from a national cross-section of US housing, which in 2000 were 1.1 microg/ft(2) and 9.4 microg/ft(2) on floors and windowsills, respectively as reported by Jacobs et al. (2002) suggests that the lead content of the dust in Delhi homes is much higher than that in the national data in the US and that the levels pose a hazard to children. Practical Implications The present study is first of its kind in this part of the world. In the context of ongoing efforts to eliminate lead from paints worldwide this research will help the scientists and policy makers in assessing the Children's exposure to lead in developing country as well. Since more than one half of the housing units tested had at least one dust lead sample exceeding US health-based standards, health care providers and public health officials need to give attention to possible lead poisoning in Delhi children. Routine blood lead screening of children should follow recommended public health practice for children at risk. Additional larger-scale studies are needed in Delhi and elsewhere to determine how representative these findings are and to attempt to delineate the sources of

  20. 24 CFR 982.618 - Shared housing: Housing quality standards.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Shared housing: Housing quality... Types Shared Housing § 982.618 Shared housing: Housing quality standards. (a) Compliance with HQS. The... the unit available for use by the assisted family under its lease, meets the housing quality...

  1. Definition of squatter housing.

    Science.gov (United States)

    Gedik, A

    1993-01-01

    One of the most critical urban problems of developing countries is squatter housing. Squatter housing was defined as housing illegally established and roughly constructed. The initial structure was small in size, made of low-quality materials, and built with nominal labor costs on squatter land with a nominal rent. The basic housing unit may be expanded over time. Squatter housing arises out of a variety of circumstances, including an inadequate supply of old depleted formal housing near the central business district. Squatter housing is attractive to migrants and others in low-income and insecure employment. Improvements in squatter housing locations are possible when spatial location problems are not a concern. Policies concerning squatter housing have changed over time. Most government policies accept the inevitability of squatter housing and seek to improve and upgrade housing and public service conditions. The literature on squatter housing spans a variety of forms of housing. The variety of forms was due to the variety of levels of development within countries, changes over time, and changes toward a more permanent population in the labor force rather then temporary migrants. The forms of housing were identified as legal-formal residential housing which excluded slums, residential slums, squatter housing, and other residential housing. Set theory was used to clarify, with explicitness and a minimum of redundancies, 14 different sets. The 14 sets revolved around socioeconomic levels, housing and environmental conditions, construction process, land ownership, zoning regulations, subdivision regulations, and building construction regulations. Legal-formal housing meant legal land ownership and conformity to legal zoning, subdivision, and building construction regulations. Usually housing was of higher quality and construction was according to a time schedule. Slum housing also conformed to legal status and a regular time span for construction, but the

  2. Dust mite (image)

    Science.gov (United States)

    This is a magnified photograph of a dust mite. Mites are carriers (vectors) of many important diseases including typhus (scrub and murine) and rickettsialpox. (Image courtesy of the Centers for Disease ...

  3. Adhesion of Lunar Dust

    Science.gov (United States)

    Walton, Otis R.

    2007-04-01

    This paper reviews the physical characteristics of lunar dust and the effects of various fundamental forces acting on dust particles on surfaces in a lunar environment. There are transport forces and adhesion forces after contact. Mechanical forces (i.e., from rover wheels, astronaut boots and rocket engine blast) and static electric effects (from UV photo-ionization and/or tribo-electric charging) are likely to be the major contributors to the transport of dust particles. If fine regolith particles are deposited on a surface, then surface energy-related (e.g., van der Walls) adhesion forces and static-electric-image forces are likely to be the strongest contributors to adhesion. Some measurement techniques are offered to quantify the strength of adhesion forces. And finally some dust removal techniques are discussed.

  4. Nano Dust Analyzer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop a new highly sensitive instrument to confirm the existence of the so-called nano-dust particles, characterize their impact parameters, and...

  5. Composite Circumstellar Dust Grains

    CERN Document Server

    Gupta, Ranjan; Dutta, Rajeshwari

    2016-01-01

    We calculate the absorption efficiencies of composite silicate grains with inclusions of graphite and silicon carbide in the spectral range 5--25$\\rm \\mu m$. We study the variation in absorption profiles with volume fractions of inclusions. In particular we study the variation in the wavelength of peak absorption at 10 and 18$\\rm \\mu m$. We also study the variation of the absorption of porous silicate grains. We use the absorption efficiencies to calculate the infrared flux at various dust temperatures and compare with the observed infrared emission flux from the circumstellar dust around some M-Type \\& AGB stars obtained from IRAS and a few stars from Spitzer satellite. We interpret the observed data in terms of the circumstellar dust grain sizes; shape; composition and dust temperature.

  6. Response Paper: Bailey, J.O. "What Happens in "The Fall of the House of Usher"?" American Literature 35.4 (1964): 445-66. Academic Search Complete. Web. 9 March. 2016.

    OpenAIRE

    Baker M. Bani-Khair

    2016-01-01

    J. O. Bailey in "What Happens in "The Fall of the House of Usher"?" (1964)  explains the possibilities of reading The Fall of the House of Usher from different angles and perspectives. It tackles the way the story is presented to the reader and the approaches Poe uses towards the psychological as well as the gothic perspectives of fear. The author’s pivotal point in the article focuses on the main characters of the story such as Roderick, Madeline and the narrator's inwardly and outwardly sen...

  7. Saving the Dust Bowl: "Big Hugh" Bennett's Triumph over Tragedy

    Science.gov (United States)

    Smith, Rebecca

    2007-01-01

    In the 1930s, years of injudicious cultivation had devastated 100 million acres of Kansas, Oklahoma, Texas, Colorado, and New Mexico. This was the Dust Bowl, and it exposed a problem that had silently plagued American agriculture for centuries--soil erosion. Farmers, scientists, and the government alike considered it trivial until Hugh Hammond…

  8. Martian Atmospheric Dust Mitigation for ISRU Intakes via Electrostatic Precipitation

    Science.gov (United States)

    Phillips, James R., III; Pollard, Jacob R. S.; Johansen, Michael R.; Mackey, Paul J.; Clements, Sid; Calle, Carlos I.

    2016-01-01

    This document is the presentation to be given at the 2016 American Society of Civil Engineers Earth and Space Conference to examine the concept of using electrostatic precipitation for Martian atmospheric dust mitigation of the intakes of in-situ resource utilization reactors.

  9. Migration of Interplanetary Dust

    OpenAIRE

    Ipatov, S. I.; Mather, J. C.; Taylor, P.A.

    2003-01-01

    We numerically investigate the migration of dust particles with initial orbits close to those of the numbered asteroids, observed trans-Neptunian objects, and Comet Encke. The fraction of silicate asteroidal particles that collided with the Earth during their lifetime varied from 1.1% for 100 micron particles to 0.008% for 1 micron particles. Almost all asteroidal particles with diameter d>4 microns collided with the Sun. The peaks in the migrating asteroidal dust particles' semi-major axis d...

  10. Situation-Based Housing

    DEFF Research Database (Denmark)

    Duelund Mortensen, Peder

    Presentation of urban housing research on flexible housing types in the Copenhagen Region: Theoretical background, methodology, analyse of spatial organization, interviews and results. Cases: Pærehaven in Ølby, Køge and M-house in Ørestad, Copenhagen......Presentation of urban housing research on flexible housing types in the Copenhagen Region: Theoretical background, methodology, analyse of spatial organization, interviews and results. Cases: Pærehaven in Ølby, Køge and M-house in Ørestad, Copenhagen...

  11. American Religion

    Institute of Scientific and Technical Information of China (English)

    田甜

    2008-01-01

    It is said that American religion,as a great part of American culture,plays an important role in American culture. It is hoped that some ideas can be obtained from this research paper,which focuses on analyzing the great impact is produced to American culture by American religion. Finally, this essay gives two useful standpoints to English learners:Understunding American religion will help understand the American history, culture and American people,and help you to communic.ate with them better. Understanding American religion will help you understand English better.

  12. Multiple metal contamination from house paints: consequences of power sanding and paint scraping in New Orleans.

    OpenAIRE

    Mielke, H W; Powell, E T; Shah, A; Gonzales, C R; Mielke, P W

    2001-01-01

    Power sanding exterior paint is a common practice during repainting of old houses in New Orleans, Louisiana, that triggers lead poisoning and releases more than Pb. In this study we quantified the Pb, zinc, cadmium, manganese, nickel, copper, cobalt, chromium, and vanadium in exterior paint samples collected from New Orleans homes (n = 31). We used interior dust wipes to compare two exterior house-painting projects. House 1 was measured in response to the plight of a family after a paint cont...

  13. Evaluation of skin sensitivity in dogs bearing allergic dermatitis to standardized allergenic extract of house dust and storage mites Avaliação da sensibilidade de cães com dermatite alérgica a extratos padronizados de ácaros da poeira domiciliar

    Directory of Open Access Journals (Sweden)

    Victor E.S. Cunha

    2007-08-01

    Full Text Available The objective of the study was to evaluate whether allergenic extracts of five house dust and storage mite species standardized for humans might be used for the diagnosis of canine atopic dermatitis (CAD. Extracts of Dermatophagoides pteronyssinus (Pyroglyphidae, D. farinae (Pyroglyphidae, Blomia tropicalis (Glycyphagidae, Lepidoglyphus destructor (Glycyphagidae and Tyrophagus putrescentiae (Acaridae were evaluated by intradermal testing in 20 healthy dogs (control and 25 dogs with allergic dermatitis. A significant difference in the response was observed between the two groups (pO presente trabalho teve como objetivo avaliar se extratos alergênicos de cinco espécies de ácaros da poeira domiciliar e produtos armazenados, padronizados para humanos, podem ser utilizados no diagnóstico da dermatite atópica canina. Extratos de Dermatophagoides pteronyssinus (Pyroglyphidae, D. farinae (Pyroglyphidae, Blomia tropicalis (Glycyphagidae, Lepidoglyphus destructor (Glycyphagidae e Tyrophagus putrescentiae (Acaridae foram avaliados através de testes intradérmicos em 45 cães, dos quais 20 normais e 25 com dermatite alérgica. Uma diferença significativa foi observada no padrão de respostas obtidas dos dois grupos (p<0.05. Apenas um animal (5% do grupo controle reagiu ao teste cutâneo, enquanto que no grupo dos alérgicos 14 cães (56% apresentaram pelo menos uma reação positiva (odds ratio = 24.2. As maiores freqüências de reações positivas observadas no grupo dos alérgicos foram aos extratos de T. putres-centiae ou L. destructor, cada um induzindo reações em 10(40% cães. Os extratos de D. farinae, D. pteronyssinus e B. tropicalis foram responsáveis por reações positivas em 7(28%, 3(12% e 3(12% cães, respectivamente. Os extratos padronizados para humanos avaliados no presente estudo podem ser utilizados como complemento no diagnóstico da doença, assim como na seleção de alérgenos para a imunoterapia alérgeno-específica.

  14. Effectiveness of house dust mite acaricide tri-n-butyl tin maleate on carpets, fabrics and mattress foam: a standardization of methodology Eficácia do acaricida maleato de estanho tri-n-butílico contra ácaros de poeira em carpetes, tecidos e espuma de colchão: padronização de metodologia

    Directory of Open Access Journals (Sweden)

    Satiko Uehara

    2006-06-01

    Full Text Available The aim of this study was to determine the effectiveness of the acaricide tri-n-butyl tin maleate, industrially applied to samples of carpets, mattress foam, and fabrics used for furniture upholstery, soft toys and shoe uppers. Approximately 100 adult house dust mites of the species Dermatophagoides pteronyssinus were inoculated into a Petri dish containing the sample (a piece of carpet, mattress foam, or fabric, treated with the acaricide, randomly collected. Mite-maintenance culture medium was added on top of each sample. After one, two, three, seven and 30 days of incubation at 25 ºC and 75% relative humidity, each dish was examined using a 40X stereoscopic microscope (40X. One hundred percent acaricide effectiveness was obtained in treated materials by the end of the 30th-day postinoculation period, under optimal conditions for mite maintenance.O objetivo do presente estudo foi verificar a eficácia do acaricida maleato de estanho tri-n-butílico, aplicado industrialmente em amostras de carpetes, tecidos de revestimentos de móveis e de calçados, assim como de espumas de colchão. Aproximadamente 100 ácaros adultos da espécie Dermatophagoides pteronyssinus foram inoculados em placa de Petri contendo a amostra (pedaço de colchão, tecido ou carpete, tratada com o produto acaricida, coletados aleatoriamente. Foi acrescentado sobre a amostra, meio de cultivo para a manutenção dos ácaros. Cada placa foi examinada após 1, 2, 3, 7 e 30 dias de incubação a 25 ºC e 75% de U.R.A. (umidade relativa do ar, sob microscópio estereoscópico com 40X de aumento. O acaricida maleato de estanho tri-n-butílico apresentou 100% de eficácia acaricida após 30 dias da aplicação, em condições ótimas para a manutenção dos ácaros.

  15. Low energy small house 50 %. Matalaenergiapientalo 50 %; Koetalotutkimus

    Energy Technology Data Exchange (ETDEWEB)

    Nieminen, J.; Kouhia, I. (Technical Research Centre of Finland, Espoo (Finland). Building Materials Lab.); Heinonen, I. (Technical Research Centre of Finland, Espoo (Finland). Lab. of Heating and Ventilation)

    1992-01-01

    The aim of the study was to design and build a small house with 50 % lower heating energy consumption than in typical existing Finnish small houses. Energy saving is based on three technologies: super insulation, airtight construction and ventilation heat recovery. The house was built in 1991, and is being monitored for a two year period that started in November 1991. The first monitoring results show the heating energy consumption of the house to be less than half the measured consumption of typical small houses located in the same area. The indoor air quality was investigated with measurements of total air change rate, air temperature and air humidity and concentrations of mineral wool fibres, dust, radon gas, formaldehyde and CO[sub 2]. The results show the air quality to be good.

  16. House Price, House Quality and Economic Growth

    NARCIS (Netherlands)

    De Vries, P.; Boelhouwer, P.J.

    2010-01-01

    The literature on housing markets suggest that periods of economic growth are characterised by a demand for better housing quality and increasing prices. The basic principles of the theory are that the short-run price fluctuations occur due to market imperfection, while over the long term, causality

  17. Newton to Einstein — dust to dust

    International Nuclear Information System (INIS)

    We investigate the relation between the standard Newtonian equations for a pressureless fluid (dust) and the Einstein equations in a double expansion in small scales and small metric perturbations. We find that parts of the Einstein equations can be rewritten as a closed system of two coupled differential equations for the scalar and transverse vector metric perturbations in Poisson gauge. It is then shown that this system is equivalent to the Newtonian system of continuity and Euler equations. Brustein and Riotto (2011) conjectured the equivalence of these systems in the special case where vector perturbations were neglected. We show that this approach does not lead to the Euler equation but to a physically different one with large deviations already in the 1-loop power spectrum. We show that it is also possible to consistently set to zero the vector perturbations which strongly constrains the allowed initial conditions, in particular excluding Gaussian ones such that inclusion of vector perturbations is inevitable in the cosmological context. In addition we derive nonlinear equations for the gravitational slip and tensor perturbations, thereby extending Newtonian gravity of a dust fluid to account for nonlinear light propagation effects and dust-induced gravitational waves

  18. Sources of radioactive contamination inside houses

    International Nuclear Information System (INIS)

    People may be exposed at home to multiple sources of nuclear radiation such as gamma, beta and alpha rays emitters. House atmosphere is polluted with nuclear radiation from water pollutants and rocks used in the construction. Radon is the only radioactive non-metallic element. Environmental organizations estimated that all houses contain varying concentrations of radon gas, and the residents are exposed to levels of radon over the years. The source of radon in houses is uranium, which may be found in rocks of the house, soil of the garden, water of the deep artesian wells and building materials, especially granite rocks. Breathing air that contains high levels of radon causes lung cancer. Radon is the second cause of lung disease after smoking. There are many means to reduce house pollution including: utilisation of air filters to remove contaminated dust particles, keep residential areas away from the establishments that use nuclear technology or embedded by nuclear waste, avoid using materials made from asbestos in construction works and proper use and disposal of chemicals and medicines containing radioactive isotopes. (author)

  19. ICI Showcase House Prototype

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-02-16

    Building Science Corporation collaborated with ICI Homes in Daytona Beach, FL on a 2008 prototype Showcase House that demonstrates the energy efficiency and durability upgrades that ICI currently promotes through its in-house efficiency program called EFactor.

  20. Housing Inventory Count

    Data.gov (United States)

    Department of Housing and Urban Development — This report displays the data communities reported to HUD about the nature of their dedicated homeless inventory, referred to as their Housing Inventory Count...

  1. Housing of Hobson's Choice

    DEFF Research Database (Denmark)

    Vestergaard, Hedvig

    2010-01-01

    This paper looks at policies implemented to improve troubled housing estates during more than two decades. Based on evaluations of implemented programmes and case studies the paper provides a basis for discussing a number of questions: • Why do we have troubled housing estates? • What is the...... definition of troubled housing estates? • Who lives on troubled housing estates? • Who owns and manages the troubled housing estates? • What have been the reasons behind improvement programmes for troubled housing estates? • What kind of improvement programmes have been implemented and with what kind of...... results? • Have improvement programmes changed the position of the estates on the local housing markets? • What are the changes in policies and results? • What are the perspectives for policy initiatives in the field of troubled housing estates?...

  2. Radon in houses

    International Nuclear Information System (INIS)

    The purpose of this study is to determine the concentrations of 222Rn and its short-lived daughter products in the air of single-family houses in the midwestern US. During the past year, more than 200 houses were added to the study, resulting in a total of more than 400 houses. So far, results are available for 270 of these houses, equally divided between the Chicago area and Bloomsburg, Pennsylvania. 6 refs

  3. Fractal dust grains in plasma

    Energy Technology Data Exchange (ETDEWEB)

    Huang, F. [College of Science, China Agricultural University, Beijing 100083 (China); Peng, R. D. [State Key Laboratory of Coal Resources and Safe Mining, China University of Mining and Technology, Beijing 100083 (China); Liu, Y. H. [Institute of Complexity Science, Qingdao University, Qingdao 266071 (China); Chen, Z. Y. [Department of Physics, Beijing University of Chemical Technology, Beijing 100029 (China); Ye, M. F.; Wang, L. [Institute of Physics, Chinese Academy of Science, Beijing 100190 (China)

    2012-09-15

    Fractal dust grains of different shapes are observed in a radially confined magnetized radio frequency plasma. The fractal dimensions of the dust structures in two-dimensional (2D) horizontal dust layers are calculated, and their evolution in the dust growth process is investigated. It is found that as the dust grains grow the fractal dimension of the dust structure decreases. In addition, the fractal dimension of the center region is larger than that of the entire region in the 2D dust layer. In the initial growth stage, the small dust particulates at a high number density in a 2D layer tend to fill space as a normal surface with fractal dimension D = 2. The mechanism of the formation of fractal dust grains is discussed.

  4. 屋尘螨过敏症母亲脐血中调节性T细胞数量上存在的缺陷%Abnormal Regulatory T Cell Numbers in Cord Blood from Atopic Mothers Sensitized to House Dust Mite

    Institute of Scientific and Technical Information of China (English)

    梁音; 王丽慧; 杨炯

    2012-01-01

    Objective: To explore whether the quantity of CD4+CD25+Foxp3+Treg cells and CD4+ IL-10+Treg cells in cord blood of atopic mothers sensitized to house dust mite is normal or not. Methods: Seven atopic mothers sensitized to house dust mites and fourteen nonatopic mothers were admitted in this study. Cord blood mononuclear cells (CBMCs) were isolated and cultured in nDer pi stimulated cultures and without stimulation. The ratios of CD4+ CD25+ Foxp3+ Treg cells and CD4+IL-10+ Treg cells among CD4+T cells were measured by flow cytometry. Results: The frequency of CD4+CD25+Foxp3+Treg cells in atopic mothers was (1. 13 ± 0. 36)%, which was significantly lower than in nonatopic mothers (3. 11 ± 1. 13)% in unstimulated cultures (P0. 05). Conclusion: The quantity of CD4+CD25+Foxp3- Treg cells and CD4+IL-10+Treg cells had defects in cord blood of atopic mothers.%目的:探讨屋尘螨过敏症母亲脐血中CD4+ CD25+ Foxp3+调节性T(Treg)细胞和CD4+ IL-10+调节性T(Treg)细胞是否存在数量上的缺陷.方法:收集7例患屋尘螨过敏症及14例无过敏症母亲的脐血,分离脐血单个核细胞(CBMC)后体外培养,分别用及不用天然屋尘螨抗原1(nDer pl)刺激,用流式细胞术检测刺激及不刺激时CD4+ CD25+ Foxp3+ Treg细胞及CD4+ IL-10+ Treg细胞占CD4+T细胞的比率.结果:不刺激时,过敏症母亲组CBMC中的CD4+ CD25+ Foxp3+ Treg细胞占CD4+T细胞的比率为(1.13±0.36)%,显著低于无过敏症母亲组的比率(3.11±1.13)%(P<0.01).尘螨抗原刺激后,两组CD4+ CD25+ Foxp3Treg细胞比率均较不刺激时升高(P<0.01),过敏症母亲组增加的比率为(0.67±0.25)%,低于无过敏症母亲组增加的比率(1.50±0.40)%(P<0.01);不刺激时,过敏症母亲组CD4+IL-10+ Treg细胞比率的中位数为0.41%,显著低于无过敏症母亲组的1.04%(P<0.01);尘螨刺激后,无过敏症组CD4+ IL-10+ Treg细胞比率2.26%较该组不刺激时比率1.04%升高(P<0.05),显著高

  5. The Tarascan Indian House.

    Science.gov (United States)

    Quinn, Joyce

    1989-01-01

    This lesson plan introduces K-grade three students to Mexican Indian architecture. Students will become familiar with the cultural context of the Indian treasure house; discuss the use of wood as the sole building material; compare the treasure house with present day structures; and create miniature treasure houses using wood materials. (GEA)

  6. Dutch house price fundamentals

    NARCIS (Netherlands)

    Haffner, M.E.A.; de Vries, P.

    2009-01-01

    This paper discusses house price developments in the Netherlands, specifically focussing on the question whether current house prices in the Dutch owner-occupied market are likely to decrease. We analyse three aspects of the question based on a literature review: (1) whether there is a house price b

  7. Dutch house price fundamentals

    OpenAIRE

    Haffner, M.E.A.; De Vries, P.

    2009-01-01

    This paper discusses house price developments in the Netherlands, specifically focussing on the question whether current house prices in the Dutch owner-occupied market are likely to decrease. We analyse three aspects of the question based on a literature review: (1) whether there is a house price bubble ready to burst; (2) whether house prices will decline in response to the credit crisis that started in 2007; and (3) whether it is likely that house prices will decrease as a result of reform...

  8. Zero energy house

    OpenAIRE

    Milián Martínez, Irene; Vink, Willem; Ortiz Braulio, Ruben

    2008-01-01

    The zero energy house project talks about sustainability. In general terms the house is designed to produce as much energy as it consume. If you take a look to the house its possible to find several systems that takes as much profit as possible to the renewable energies like photovoltaic electricity production, geothermal energy used to run a heat pump or a well thought isolated house. First of all it’s possible to find general information about the topics in house, to make people understa...

  9. The Relationship of Housing and Population Health: A 30-Year Retrospective Analysis

    OpenAIRE

    Jacobs, David E.; Wilson, Jonathan; Dixon, Sherry L.; Smith, Janet; Evens, Anne

    2008-01-01

    Objective We analyzed the relationship between health status and housing quality over time. Methods We combined data from two nationally representative longitudinal surveys of the U.S. population and its housing, the National Health and Nutrition Examination Survey and the American Housing Survey, respectively. We identified housing and health trends from approximately 1970 to 2000, after excluding those trends for which data were missing or where we found no plausible association or change i...

  10. Assisted Housing - Multifamily Properties - Assisted

    Data.gov (United States)

    Department of Housing and Urban Development — HUD's Multifamily Housing property portfolio consist primarily of rental housing properties with five or more dwelling units such as apartments or town houses, but...

  11. Dust exposure in Finnish foundries.

    Science.gov (United States)

    Siltanen, E; Koponen, M; Kokko, A; Engström, B; Reponen, J

    1976-01-01

    Dust measurements were made in 51 iron, 9 steel, and 8 nonferrous foundries, at which 4,316 foundrymen were working. The sampling lasted at least two entire shifts or work days continuously during various operations in each foundry. The dust samples were collected at fixed sites or in the breathing zones of the workers. The mass concentration was determined by weighing and the respirable dust fraction was separated by liquid sedimentation. The free silica content was determined by X-ray diffraction. In the study a total of 3,188 samples were collected in the foundries and 6,505 determinations were made in the laboratory. The results indicated a definite difference in the dust exposure during various operations. The highest dust exposures were found during furnace, cupola, and pouring ladle repair. During cleaning work, sand mixing, and shake-out operations excessive silica dust concentrations were also measured. The lowest dust concentrations were measured during melting and pouring operations. Moderate dust concentrations were measured during coremaking and molding operations. The results obtained during the same operations of iron and steel foundries were similar. The distribution of the workers into various exposure categories, the content of respirable dust and quartz, the correlation between respirable dust and total dust, and the correlation between respirable silica and total dust concentrations are discussed. Observations concerning dust suppression and control methods are briefly considered. PMID:184524

  12. Moodulmaja Passion House = "Passion House" modular home

    Index Scriptorium Estoniae

    2015-01-01

    Moodulmaja Passion House. Arhitektuuri sihtkapitali innovatsioonipreemia 2013 kvaliteetse disaini ja perspektiivika arendustegevuse oskusliku sidumise eest. Arhitekt Eero Endjärv (Arhitekt11), sisearhitekt Hannelore Kääramees (Arhitekt11)

  13. Analytical Study of Nonlinear Dust Acoustic Waves in Two-Dimensional Dust Plasma with Dust Charge Variation

    Institute of Scientific and Technical Information of China (English)

    LIN Chang; ZHANG Xiu-Lian

    2005-01-01

    The nonlinear dust acoustic waves in two-dimensional dust plasma with dust charge variation is analytically investigated by using the formally variable separation approach. New analytical solutions for the governing equation of this system have been obtained for dust acoustic waves in a dust plasma for the first time. We derive exact analytical expressions for the general case of the nonlinear dust acoustic waves in two-dimensional dust plasma with dust charge variation.

  14. Consumer Problems of Older Americans. New Directions for Government and Business. Background Papers and Recommendations from a Mini-Conference for the White House Conference on Aging (Washington, DC, January 29-30, 1980).

    Science.gov (United States)

    National Retired Teachers Association, Washington, DC.

    These background papers and recommendations from a mini-conference on the consumer problems of older Americans and new directions that government and business should take to protect the consumer rights of the elderly address the following areas: credit, food, insurance, investments, prescription drugs and medical appliances, and primary health…

  15. The affordability of homeownership to middle-income Americans

    OpenAIRE

    Jordan Rappaport

    2008-01-01

    From 1971 through mid-2007, the nominal national sales price of housing grew almost eightfold. Controlling for inflation, this represented a near doubling in the relative price of housing. The retrenchment in prices that began in 2007 has so far remained small compared to the earlier increase. ; As house prices climbed, many people complained that housing had become unaffordable to middle-income Americans. As early as 1998, newspapers warned that homeownership was becoming a heavy financial b...

  16. Dust-Dust Collisional Charging and Lightning in Protoplanetary Discs

    CERN Document Server

    Muranushi, Takayuki

    2009-01-01

    We study the role of dust-dust collisional charging in protoplanetary discs. We show that dust-dust collisional charging becomes an important process in determining the charge state of dust and gas, if there is dust enhancement and/or dust is fluffy, so that dust surface area per disc volume is locally increased. We solve the charge equilibrium equations for various disc environments and dust condensation $\\eta$ (dust number density of the considered region divided by the fiducial value), using general purpose graphic processors (GPGPU) and {\\sc cuda} programming language. We found that as dust condensation $\\eta$ increases, the charge distribution experience four phases. In one of these phases the electrostatic field $E$ caused by dust migration increases as $E \\propto \\eta^4$. As a result, macroscopic electric discharge takes place typically at $\\eta = 30 \\sim 300$. We present a model that describes the charge exchange processes in the discs as an electric circuit. We estimate the total energy, intensity an...

  17. Dust-Plasma Interactions

    International Nuclear Information System (INIS)

    The objective of our theoretical research under this grant over the past 3 years was to develop new understanding in a range of topics in the physics of dust-plasma interactions, with application to space and the laboratory. We conducted studies related to the physical properties of dust, waves and instabilities in both weakly coupled and strongly coupled dusty plasmas, and innovative possible applications. A major consideration in our choice of topics was to compare theory with experiments or observations, and to motivate new experiments, which we believe is important for developing this relatively new field. Our research is summarized, with reference to our list of journal publications.

  18. Mass transfer of PBDEs from plastic TV casing to indoor dust via three migration pathways — A test chamber investigation

    Energy Technology Data Exchange (ETDEWEB)

    Rauert, C.; Harrad, S., E-mail: S.J.Harrad@bham.ac.uk

    2015-12-01

    Polybrominated diphenyl ethers (PBDEs) are widely detected in humans with substantial exposure thought to occur in indoor environments and particularly via contact with indoor dust. Despite this, knowledge of how PBDEs migrate to indoor dust from products within which they are incorporated is scarce. This study utilises an in-house designed and built test chamber to investigate the relative significance of different mechanisms via which PBDEs transfer from source materials to dust, using a plastic TV casing treated with the Deca-BDE formulation as a model source. Experiments at both room temperature and 60 °C revealed no detectable transfer of PBDEs from the TV casing to dust via volatilisation and subsequent partitioning. In contrast, substantial transfer of PBDEs to dust was detected when the TV casing was abraded using a magnetic stirrer bar. Rapid and substantial PBDE transfer to dust was also observed in experiments in which dust was placed in direct contact with the source. Based on these experiments, we suggest that for higher molecular weight PBDEs like BDE-209; direct dust:source contact is the principal pathway via which source-to-dust transfer occurs. - Highlights: • Transfer from a TV casing to dust of high molecular weight PBDEs examined. • Direct source:dust contact effected rapid and most substantial transfer. • Substantial source:dust transfer also occurred via abrasion of source.

  19. Mass transfer of PBDEs from plastic TV casing to indoor dust via three migration pathways — A test chamber investigation

    International Nuclear Information System (INIS)

    Polybrominated diphenyl ethers (PBDEs) are widely detected in humans with substantial exposure thought to occur in indoor environments and particularly via contact with indoor dust. Despite this, knowledge of how PBDEs migrate to indoor dust from products within which they are incorporated is scarce. This study utilises an in-house designed and built test chamber to investigate the relative significance of different mechanisms via which PBDEs transfer from source materials to dust, using a plastic TV casing treated with the Deca-BDE formulation as a model source. Experiments at both room temperature and 60 °C revealed no detectable transfer of PBDEs from the TV casing to dust via volatilisation and subsequent partitioning. In contrast, substantial transfer of PBDEs to dust was detected when the TV casing was abraded using a magnetic stirrer bar. Rapid and substantial PBDE transfer to dust was also observed in experiments in which dust was placed in direct contact with the source. Based on these experiments, we suggest that for higher molecular weight PBDEs like BDE-209; direct dust:source contact is the principal pathway via which source-to-dust transfer occurs. - Highlights: • Transfer from a TV casing to dust of high molecular weight PBDEs examined. • Direct source:dust contact effected rapid and most substantial transfer. • Substantial source:dust transfer also occurred via abrasion of source

  20. Electrostatic Characterization of Lunar Dust

    Science.gov (United States)

    2008-01-01

    To ensure the safety and success of future lunar exploration missions, it is important to measure the toxicity of the lunar dust and its electrostatic properties. The electrostatic properties of lunar dust govern its behavior, from how the dust is deposited in an astronaut s lungs to how it contaminates equipment surfaces. NASA has identified the threat caused by lunar dust as one of the top two problems that need to be solved before returning to the Moon. To understand the electrostatic nature of lunar dust, NASA must answer the following questions: (1) how much charge can accumulate on the dust? (2) how long will the charge remain? and (3) can the dust be removed? These questions can be answered by measuring the electrostatic properties of the dust: its volume resistivity, charge decay, charge-to-mass ratio or chargeability, and dielectric properties.

  1. 75 FR 4100 - Affirmative Fair Housing, Marketing (AFHM) Plan-Multifamily Housing, Affirmative Fair Housing...

    Science.gov (United States)

    2010-01-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT Affirmative Fair Housing, Marketing (AFHM) Plan-Multifamily Housing, Affirmative Fair Housing Marketing (AFHM) Plan-Single Family Housing and Affirmative Fair Housing Marketing (AFHM)...

  2. Dust-Plasma Interactions

    International Nuclear Information System (INIS)

    Our theoretical research on dust-plasma interactions has concentrated on three main areas: (a)studies of grain charging and applications; (b) waves and instabilities in weakly correlated dusty plasma with applications to space and laboratory plasmas; (c) waves in strongly coupled dusty plasmas.

  3. Dust devil dynamics

    Science.gov (United States)

    Horton, W.; Miura, H.; Onishchenko, O.; Couedel, L.; Arnas, C.; Escarguel, A.; Benkadda, S.; Fedun, V.

    2016-06-01

    A self-consistent hydrodynamic model for the solar heating-driven onset of a dust devil vortex is derived and analyzed. The toroidal flows and vertical velocity fields are driven by an instability that arises from the inversion of the mass density stratification produced by solar heating of the sandy surface soil. The nonlinear dynamics in the primary temperature gradient-driven vertical airflows drives a secondary toroidal vortex flow through a parametric interaction in the nonlinear structures. While an external tangential shear flow may initiate energy transfer to the toroidal vortex flow, the nonlinear interactions dominate the transfer of vertical-radial flows into a fast toroidal flow. This secondary flow has a vertical vorticity, while the primary thermal gradient-driven flow produces the toroidal vorticity. Simulations for the complex nonlinear structure are carried out with the passive convection of sand as test particles. Triboelectric charging modeling of the dust is used to estimate the charging of the sand particles. Parameters for a Dust Devil laboratory experiment are proposed considering various working gases and dust particle parameters. The nonlinear dynamics of the toroidal flow driven by the temperature gradient is of generic interest for both neutral gases and plasmas.

  4. Left in the Dust

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    NASA's Stardust spacecraft ended its seven-year voyage January 15 after a safe landing on earth, bringing back a capsule of comet particles and samples of interstellar dust that exceeded the loftiest of expectations of mission scientists. The ensuing studies of the cosmic treasure are expected to shed light on the origins of the solar system and earth itself.

  5. Dust Devil Dynamics

    Science.gov (United States)

    Correa, C. E.; Escarguel, A.; Horton, W.; Arnas, C.; Couedel, L.; Benkadda, S.

    2013-12-01

    A self-consistent hydrodynamic model for the onset of a dust devil vortex is derived and analyzed. The horizontal toroidal flow and vertical velocity field are driven by the vertical temperature gradient instability of gravity waves. The critical temperature gradient is derived and the associated eigenmodes for simple models are given. The nonlinear dynamics in the vertical/horizontal flows drive the toroidal flow through a parametric decay process. Methods developed for triboelectric charging of dust are used to compute the electric polarization vector from the charging of the sand particles. Elementary comparisons are made with the data from dust devil observations and research and simulations by Farrell et al. 2004, 2006. The parameters for a proposed Dust Devil laboratory experiment at Aix-Marseille University are presented. Following R. L. Miller et al. JGR 2006 estimates are made of the overall contribution to the mid-latitude aerosol layer in the atmosphere that acts to moderate global climate temperature increases through a negative feedback loop. The problem has an analog in terms of the heating of the boron or beryllium coated steel vacuum vessel walls in tokamaks where the core plasma plays the role of the sun and has a temperature (~ 10keV ) that exceeds that of the core of the sun.

  6. Domotics Project Housing Block

    OpenAIRE

    Carlos Morón; Alejandro Payán; Alfonso García; Francisco Bosquet

    2016-01-01

    This document develops the study of an implementation project of a home automation system in a housing placed in the town of Galapagar, Madrid. This house, which is going to be occupied by a four-member family, consists of 67 constructed square meters distributed in lounge, kitchen, three bedrooms, bath, bathroom and terrace, this being a common arrangement in Spain. Thus, this study will allow extracting conclusions about the adequacy of the home automation in a wide percentage of housing in...

  7. Intelligent house control system

    OpenAIRE

    Stražišar, Rok

    2008-01-01

    The thesis describes a smart house and the system that empowers it with intelligence. The goal of the thesis is to present the hardware and software involved and debate about the usability, pros and cons of such a system. The work addresses the smart house from several viewpoints: safety, comfort, economy, accessibility for people with special needs and affordability. Using smart house makes every day´s life more secure and comfortable, while it also enables independency to the people with sp...

  8. In-house communication

    OpenAIRE

    Červenková, Petra

    2012-01-01

    The subject of this thesis on the topic „In-house communication“ is to create a proposal of solution and recommendations to remove possible weaknesses and defects of in-house communication in a particular company located in the Usti region. The current in-house communication will be evaluated and there will be theoretical basis of the issue found. The theoretical part establishes a framework that presented as a basis for the practical part, which consists of the particular company descri...

  9. Sustainable Housing Renewal

    OpenAIRE

    M. Sitar; K. Krajnc

    2008-01-01

    Following the already proved models the sustainable planning culture is endangering several methods directed towards the needs of tenants in the existing post-war housing stock. The case-study of our project is the renewal of the multi stored building in the housing estate Metalna, Maribor/Tezno (1949). It is based on the sustainable renovation principle for the quality of sustainable housing in functional, technological and environmental point of view. According to it, the idea of the projec...

  10. The architects house

    DEFF Research Database (Denmark)

    Welling, Helen

    2007-01-01

    The architects house is an article on Edward Heiberg's own house built in 1924. Edward Heiberg was a strong advocate of functionalism, and of the notion that hitherto individualistic and emotional architecture should be replaced by an objective function-based architecture with dwellings for every......The architects house is an article on Edward Heiberg's own house built in 1924. Edward Heiberg was a strong advocate of functionalism, and of the notion that hitherto individualistic and emotional architecture should be replaced by an objective function-based architecture with dwellings...

  11. Effect of Dust Storms on the Atmospheric Microbiome in the Eastern Mediterranean.

    Science.gov (United States)

    Mazar, Yinon; Cytryn, Eddie; Erel, Yigal; Rudich, Yinon

    2016-04-19

    We evaluated the impact of Saharan dust storms on the local airborne microbiome in a city in the Eastern Mediterranean area. Samples of particles with diameter less than 10 μm were collected during two spring seasons on both dusty and nondusty days. DNA was extracted, and partial 16S rRNA gene amplicons were sequenced using the Illumina platform. Bioinformatic analysis showed the effect of dust events on the diversity of the atmospheric microbiome. The relative abundance of desert soil-associated bacteria increased during dust events, while the relative abundance of anthropogenic-influenced taxa decreased. Quantitative polymerase chain reaction measurements of selected clinically significant antibiotic resistance genes (ARGs) showed that their relative abundance decreased during dust events. The ARG profiles on dust-free days were similar to those in aerosol collected in a poultry house, suggesting a strong agricultural influence on the local ambient profiles. We conclude that dust storms enrich the ambient airborne microbiome with new soil-derived bacteria that disappear as the dust settles, suggesting that the bacteria are transported attached to the dust particles. Dust storms do not seem to be an important vector for transport of probed ARGs. PMID:27001166

  12. Dust processing in elliptical galaxies

    CERN Document Server

    Hirashita, Hiroyuki; Villaume, Alexa; Srinivasan, Sundar

    2015-01-01

    We reconsider the origin and processing of dust in elliptical galaxies. We theoretically formulate the evolution of grain size distribution, taking into account dust supply from asymptotic giant branch (AGB) stars and dust destruction by sputtering in the hot interstellar medium (ISM), whose temperature evolution is treated by including two cooling paths: gas emission and dust emission (i.e. gas cooling and dust cooling). With our new full treatment of grain size distribution, we confirm that dust destruction by sputtering is too efficient to explain the observed dust abundance even if AGB stars continue to supply dust grains, and that, except for the case where the initial dust-to-gas ratio in the hot gas is as high as $\\sim 0.01$, dust cooling is negligible compared with gas cooling. However, we show that, contrary to previous expectations, cooling does not help to protect the dust; rather, the sputtering efficiency is raised by the gas compression as a result of cooling. We additionally consider grain grow...

  13. Disco’s Revenge: House Music’s Nomadic Memory

    OpenAIRE

    Hillegonda C. Rietveld

    2011-01-01

    This article addresses the role of house music as a nomadic archival institution, constituted by the musical history of disco, invigorating this dance genre by embracing new production technologies and keeping disco alive through a rhizomic assemblage of its affective memory in the third record of the DJ mix. This exploration will be illustrated through a close analysis of a specific DJ set by a Chicago house music producer, Larry Heard, in the setting of Rotterdam, 2007, in which American ho...

  14. Dust arising during steelmaking processes

    Directory of Open Access Journals (Sweden)

    P. Popielska-Ostrowska

    2012-12-01

    Full Text Available Purpose: This paper describes the dust arising during steelmaking processes.Design/methodology/approach: Steelmaking dusts may be a viable alternative for obtaining valuable and widely used metal which is zinc. On the other hand, heavy metals, it was as dangerous to the environment, and this in turn means that development of steelmaking dusts in the best possible way.Findings: The analysis of the formation of steelmaking dust.Research limitations/implications: Understanding the mechanism of steelmaking dusts will help to increase the participation of zinc recycling from wastes.Practical implications: Contained zinc in the dust can be recovered from the positive economic effect, and neutralization of hazardous waste to the desired environmental effect.Originality/value: Description of the mechanism of steelmaking dust, with particular emphasis on the distribution of zinc. The information is very important in the development of metal recovery technology from waste.

  15. Response Paper: Bailey, J.O. "What Happens in "The Fall of the House of Usher"?" American Literature 35.4 (1964: 445-66. Academic Search Complete. Web. 9 March. 2016.

    Directory of Open Access Journals (Sweden)

    Baker M. Bani-Khair

    2016-07-01

    Full Text Available J. O. Bailey in "What Happens in "The Fall of the House of Usher"?" (1964  explains the possibilities of reading The Fall of the House of Usher from different angles and perspectives. It tackles the way the story is presented to the reader and the approaches Poe uses towards the psychological as well as the gothic perspectives of fear. The author’s pivotal point in the article focuses on the main characters of the story such as Roderick, Madeline and the narrator's inwardly and outwardly sense of terror, fear, and haunting. He explains that each one of these characters represents different possibilities, and, therefore, requires approaching the text from multifarious perspectives, such as going back to Poe’s autobiographical life and the history of his education, and the knowledge that Poe was exposed to during his life time.In fact, the author introduces new techniques that give a better reading of The Fall of the House of Usher. He deconstructs the text through giving a new different analytical reading of the story and explaining the layers the story implies in the understanding of the gothic as well as highlighting the theme of “the vampire Lore” in the story, which the author believes that Poe has implicitly used in his story. He thinks it is impossible to say for sure what Poe read, but he believes that The Fall of the House of Usher has much in common with the gothic “features of Vampire lore” Bailey states:I think it is a safe guess that Poe also read Polidori’s The Vampire, which has a six-page introduction to define a vampire and discuss various legends, in legends and literary developments, to a complex “kith and kin” of demonic possession and witchcraft. I think it is impossible to discover what Poe read, but logical to compare his story with typical features of vampire lore. (449 Having this possibility and the “vampire lore” in mind, Bailey approaches each one of the characters from this specific angle

  16. Organophosphorus flame retardants and phthalate esters in indoor dust from different microenvironments: Bioaccessibility and risk assessment.

    Science.gov (United States)

    He, Ruiwen; Li, Yunzi; Xiang, Ping; Li, Chao; Zhou, Chunyang; Zhang, Shujun; Cui, Xinyi; Ma, Lena Q

    2016-05-01

    Incidental ingestion of indoor dust is an important pathway for human exposure to organophosphorus flame retardants (OPFRs) and phthalate esters (PAEs). However, little is known about their bioaccessibility in indoor dust. In this study, indoor dust samples were collected from houses, offices, public microenvironments (PMEs), and university dorms, and physiologically based extraction test (PBET) was used to measure the bioaccessibility of OPFRs and PAEs in these dust samples. Total concentrations of OPFRs in dust samples ranged from 0.01 to 63.2 μg g(-1), with significantly lower concentrations in dorm dust (median = 0.30 μg g(-1)) than those in houses (3.12), offices (5.94), and PMEs (11.6). Total PAEs ranged from 5.49 to 2161 μg g(-1) with significantly lower concentrations in dorm dust (379 μg g(-1)) than those in the other three types of dust (767, 515, and 731 μg g(-1)). When subject to PBET, the bioaccessibility of OPFRs ranged from 8.18% (triphenyl phosphate) to 54.5% (Tris(2-chloroisopropyl) phosphate) for OPFRs, and from 1.21% (di-2-ethylhexyl phthalate, DEHP) to 81.1% (dimethyl phthalate) for PAEs. Estimated exposure doses for adults and infants to OPFRs via dust ingestion were much lower than the reference doses (RfD), but intake dose of DEHP for infants was higher than the RfD of 20 μg kg(-1) d(-1). However, the DEHP intake dose did not exceed the RfD after incorporating bioaccessibility into risk assessment. Our data indicated the importance of considering contaminant bioaccessibility during risk assessment of indoor dust. PMID:26585356

  17. Particulate emission abatement for Krakow boiler houses

    Energy Technology Data Exchange (ETDEWEB)

    Wysk, R.

    1995-12-31

    Among the many strategies for improving air quality in Krakow, one possible method is to adapt new and improved emission control technology. This project focuses on such a strategy. In order to reduce dust emissions from coal-fueled boilers, a new device called a Core Separator has been introduced in several boiler house applications. This advanced technology has been successfully demonstrated in Poland and several commercial units are now in operation. Particulate emissions from the Core Separator are typically 3 to 5 times lower than those from the best cyclone collectors. It can easily meet the new standard for dust emissions which will be in effect in Poland after 1997. The Core Separator is a completely inertial collector and is based on a unique recirculation method. It can effectively remove dust particles below 10 microns in diameter, the so-called PM-10 emissions. Its performance approaches that of fabric filters, but without the attendant cost and maintenance. It is well-suited to the industrial size boilers located in Krakow. Core Separators are now being marketed and sold by EcoInstal, one of the leading environmental firms in Poland, through a cooperative agreement with LSR Technologies.

  18. Brominated and organophosphate flame retardants in indoor dust of Jeddah, Kingdom of Saudi Arabia: Implications for human exposure.

    Science.gov (United States)

    Ali, Nadeem; Eqani, Syed Ali Musstjab Akber Shah; Ismail, Iqbal Mohammad Ibrahim; Malarvannan, Govindan; Kadi, Mohammad W; Albar, Hussain Mohammed Salem; Rehan, Mohammad; Covaci, Adrian

    2016-11-01

    Different flame retardants (FRs) namely polybrominated diphenyl ethers (PBDEs), emerging brominated/chlorinated flame retardants (Br/Cl FRs), and organophosphate FRs (OPFRs) were analyzed in cars, air conditioner (AC) filters and floor dust of different households from Jeddah, Kingdom of Saudi Arabia (KSA). To the best of our knowledge, this is first study in literature reporting emerging Br/Cl FRs and OPFRs in AC filter dust and also first to report on their occurrence in dust from KSA. Chlorinated alkyl phosphate, penta-BDEs, BDE-209, and decabromodiphenylethane (DBDPE) were the major chemicals in dust samples from all microenvironments. ΣOPFRs occurred at median concentrations (ng/g dust) of 15,400, 10,500, and 3750 in AC filter, car and house floor dust, respectively. For all analyzed chemicals, relatively lower levels were observed in floor dust than car and AC filter dust. The profiles of FRs in car dust were different from AC filter and floor dust, which reflected their wider application as FR and plasticizer in variety of household and commercial products. For toddlers, assuming high dust intake and 95th percentile concentrations, the computed exposure estimation for BDE-99 was higher than RfD values. PMID:27343946

  19. Distribution of pesticides in dust particles in urban environments.

    Science.gov (United States)

    Richards, Jaben; Reif, Ruben; Luo, Yuzhuo; Gan, Jay

    2016-07-01

    In regions with a mild climate, pesticides are often used around homes for pest control. Recent monitoring studies have linked pesticide use in residential areas to aquatic toxicity in urban surface water ecosystems, and suggested dust particles on paved surfaces as an important source of pesticides. To test the hypothesis that dust on hard surfaces is a significant source of pesticides, we evaluated spatial and temporal patterns of current-use insecticides in Southern California, and further explored their distribution as a function of particle sizes. Pyrethroid insecticides were detected in dust from the driveway, curb gutter and street at 53.5-94.8%, with median concentrations of 1-46 ng g(-1). Pyrethroid residues were uniformly distributed in areas adjacent to a house, suggesting significant redistribution. The total levels of pyrethroids in dust significantly (p < 0.01) decreased from October to February, suggesting rainfalls as a major mechanism to move pesticide residues offsite. Fipronil as well as its degradation products, were detected at 50.6-75.5%, and spatial and temporal patterns of fipronil residues suggested rapid transformations of fipronil to its biologically active intermediates. Moreover, pyrethroids were found to be enriched in fine particles that have a higher mobility in runoff than coarse particles. Results from this study highlight the widespread occurrence of pesticides in outdoor dust around homes and the potential contribution to downstream surface water contamination via rain-induced runoff. PMID:27105165

  20. Gravimetric Analysis of Particulate Matter using Air Samplers Housing Internal Filtration Capsules

    OpenAIRE

    O'Connor, Sean; O'Connor, Paula Fey; Feng, H. Amy; Ashley, Kevin

    2014-01-01

    An evaluation was carried out to investigate the suitability of polyvinyl chloride (PVC) internal capsules, housed within air sampling devices, for gravimetric analysis of airborne particles collected in workplaces. Experiments were carried out using blank PVC capsules and PVC capsules spiked with 0,1 – 4 mg of National Institute of Standards and Technology Standard Reference Material® (NIST SRM) 1648 (Urban Particulate Matter) and Arizona Road Dust (Air Cleaner Test Dust). The capsules were ...

  1. Ecological assessment of process of thermal energy generation at boiler-houses with small capacity

    International Nuclear Information System (INIS)

    Ecologic effectiveness of power generation process at boiler-houses with small capacity is estimated. Both the material and thermal balances describing quantitative motion of materials, capacity of recoverable resources generation, applying wastes, losses values are carried out. Balances are developed for two cases: 1. without heat utilization of discharge gases and without precipitation of dust discharges; 2. with heat utilization and with precipitation of dust discharges under equal productivity and operation conditions. Results are sited in tabular form

  2. Public Housing, Housing Vouchers and Student Achievement: Evidence from Public Housing Demolitions in Chicago

    OpenAIRE

    Brian A. Jacob

    2003-01-01

    There has been a substantial shift from public housing to voucher-based housing assistance over the past decade, largely in response to the rising cost of public housing and the high rates of crime, unemployment and school failure among public housing residents. Despite this shift, there is relatively little evidence on the impact of public housing or housing vouchers on educational outcomes. This paper utilizes a plausibly exogenous source of variation in housing assistance generated by publ...

  3. Financing social housing

    Czech Academy of Sciences Publication Activity Database

    Amann, W.; Hegedüs, J.; Lux, Martin; Springler, E.

    New York/Londýn: Routledge, 2013 - (Hegedüs, J.; Lux, M.; Teller, N.), s. 50-64 ISBN 978-0-415-89014-4 R&D Projects: GA ČR GA403/09/1915 Institutional research plan: CEZ:AV0Z70280505 Keywords : Housing finance * transition countries * social housing Subject RIV: AO - Sociology, Demography

  4. Multiple pump housing

    Science.gov (United States)

    Donoho, II, Michael R.; Elliott; Christopher M.

    2010-03-23

    A fluid delivery system includes a first pump having a first drive assembly, a second pump having a second drive assembly, and a pump housing. At least a portion of each of the first and second pumps are located in the housing.

  5. Dream house in Australia

    DEFF Research Database (Denmark)

    Andersen, Michael Asgaard

    2004-01-01

    This first book in the Utzon Library, which deals with Utzon's own houses, contains a number of drawings that have not previously been published. This is especially true of the four projects for his house in Bayview, Sydney, which unfortunately never got past the drawing stage, as Utzon had left...

  6. Radon house doctor

    International Nuclear Information System (INIS)

    The term house doctor may be generalized to include persons skilled in the use of instruments and procedures necessary to identify, diagnose, and correct indoor air quality problems as well as energy, infiltration, and structural problems in houses. A radon house doctor would then be a specialist in radon house problems. Valuable experience in the skills necessary to be developed by radon house doctors has recently been gained in an extensive radon monitoring and mitigation program in upstate New York sponsored by Niagara Mohawk Power Corporation and the New York State Energy Research and Development Authority. These skills, to be described in detail in this paper, include: (i) the use of appropriate instruments, (ii) the evaluation of the symptoms of a radon-sick house, (iii) the diagnostic procedures required to characterize radon sources in houses, (iv) the prescription procedures needed to specify treatment of the problem, (v) the supervision of the implementation of the treatment program, (vi) the check-up procedures required to insure the house cured of radon problems. 31 references, 3 tables

  7. Housing for Graduate Students.

    Science.gov (United States)

    Mielke, Patricia L.; Schuh, John H.

    1995-01-01

    Suggests that housing administrators must develop close cooperation with their institution's graduate school, be sensitive to the needs of international graduate students, and engage in thoughtful deliberation about issues related to domestic partners, health care, spouses, and children. Profiles housing's mission and philosophy, organizational…

  8. Ndebele Inspired Houses

    Science.gov (United States)

    Rice, Nicole

    2012-01-01

    The house paintings of the South African Ndebele people are more than just an attempt to improve the aesthetics of a community; they are a source of identity and significance for Ndebele women. In this article, the author describes an art project wherein students use the tradition of Ndebele house painting as inspiration for creating their own…

  9. Dust in External Galaxies

    OpenAIRE

    Calzetti, Daniela

    2009-01-01

    Existing (Spitzer Space Telescope) and upcoming (Herschel Space Telescope) facilities are deepening our understanding of the role of dust in tracing the energy budget and chemical evolution of galaxies. The tools we are developing while exploring the local Universe will in turn become pivotal in the interpretation of the high redshift Universe when near--future facilities (the Atacama Large Millimeter Array [ALMA], the Sub--Millimeter Array [SMA], the Large Millimeter Telescope [LMT], the Jam...

  10. Transport of Dust Particles in Tokamak Devices

    Energy Technology Data Exchange (ETDEWEB)

    Pigarov, A Y; Smirnov, R D; Krasheninnikov, S I; Rognlien, T D; Rozenberg, M

    2006-06-06

    Recent advances in the dust transport modeling in tokamak devices are discussed. Topics include: (1) physical model for dust transport; (2) modeling results on dynamics of dust particles in plasma; (3) conditions necessary for particle growth in plasma; (4) dust spreading over the tokamak; (5) density profiles for dust particles and impurity atoms associated with dust ablation in tokamak plasma; and (6) roles of dust in material/tritium migration.

  11. Situation based housing

    DEFF Research Database (Denmark)

    Duelund Mortensen, Peder; Welling, Helen; Wiell Nordberg, Lene;

    2007-01-01

    variety of approaches to these goals. This working paper reviews not only a selection of new housing types, but also dwellings from the past, which each contain an aspect of changeability. Our study is based on information from users in the selected housing schemes, gathered from questionnaires...... the average family's lifestyle. These dwellings were ground-breaking when they were built, but today are clearly a product of their time. The reaction to functionalism and the postwar mass production gave rise to flexible dwelling with countless possibilities for room division. The housing of this...... period has characteristics which in the long run have proven to be unfortunate both in terms in terms of durability and architectural quality. Today there is a focus on the development of more open and functionally non-determined housing. A number of new housing schemes in and around Copenhagen reveal a...

  12. Nordic Housing Enabler

    DEFF Research Database (Denmark)

    Helle, Tina; Brandt, Åse

    2009-01-01

    Development and reliability testing of the Nordic Housing Enabler – an instrument for accessibility assessment of the physical housing. Tina Helle & Åse Brandt University of Lund, Health Sciences, Faculty of Medicine (SE) and University College Northern Jutland, Occupational Therapy department (DK......, however, the built environment shows serious deficits when it comes to accessibility. This study addresses development of a content valid cross-Nordic version of the Housing Enabler and investigation of inter-rater reliability, when used in occupational therapy practice. The instrument was translated from...... the original Swedish version and adapted according to accessibility norms and guidelines for housing design in Sweden, Denmark, Iceland and Finland. This iterative process involved occupational therapists, architects, building engineers and professional translators, resulting in the Nordic Housing...

  13. Assisted Housing - Public Housing Developments - National Geospatial Data Asset (NGDA)

    Data.gov (United States)

    Department of Housing and Urban Development — The general location of an entire Public Housing Development. A distinct address is chosen to represent the general location of an entire Public Housing...

  14. Assisted Housing - Public Housing Authorities - National Geospatial Data Asset (NGDA)

    Data.gov (United States)

    Department of Housing and Urban Development — Public Housing was established to provide decent and safe rental housing for eligible low-income families, the elderly, and persons with disabilities. Public...

  15. Dust, Climate, and Human Health

    Science.gov (United States)

    Maynard, Nancy G.

    2003-01-01

    Air pollution from both natural and anthropogenic causes is considered to be one of the most serious world-wide environment-related health problems, and is expected to become worse with changes in the global climate. Dust storms from the atmospheric transport of desert soil dust that has been lifted and carried by the winds - often over significant distances - have become an increasingly important emerging air quality issue for many populations. Recent studies have shown that the dust storms can cause significant health impacts from the dust itself as well as the accompanying pollutants, pesticides, metals, salt, plant debris, and other inorganic and organic materials, including viable microorganisms (bacteria, viruses and fungi). For example, thousands of tons of Asian desert sediments, some containing pesticides and herbicides from farming regions, are commonly transported into the Arctic during dust storm events. These chemicals have been identified in animal and human tissues among Arctic indigenous populations. Millions of tons of airborne desert dust are being tracked by satellite imagery, which clearly shows the magnitude as well as the temporal and spatial variability of dust storms across the "dust belt" regions of North Africa, the Middle East, and China. This paper summarizes the most recent findings on the effects of airborne desert dust on human health as well as potential climate influences on dust and health.

  16. Systems for eliminating pathogens from exhaust air of animal houses

    OpenAIRE

    Aarnink, A.J.A.; Landman, W.J.M.; Melse, R.W.; Huynh Thi Thanh Thuy

    2005-01-01

    Recent outbreaks of highly infectious viral diseases like swine fever and avian influenza in The Netherlands have shown that despite extensive bio-security measures aiming at minimizing physical contacts between farms, disease spread could not be halted. Dust in exhaust air from swine and chicken houses may provide a favorable environment in which these viruses and other pathogenic microorganisms can survive and be transported over long distances to other farms. In a field study and in an exp...

  17. Housing management and maintenance practise of Dutch housing associations

    OpenAIRE

    Straub, A.

    2004-01-01

    This paper summarises the state-of-the-art in housing management and maintenance practise of Dutch housing associations based on a survey conducted among almost all housing associations. We address the question what the current developments are in housing management and maintenance practice in the Netherlands. In a housing stock policy document a housing association constructs a picture of the composition of the desirable dwelling portfolio and sets up market and complex strategies. 71% of th...

  18. The housing bust and housing affordability in New England

    OpenAIRE

    Robert Clifford

    2010-01-01

    This discussion paper updates the Center's 2006 housing affordability working paper, drawing on housing market data through 2008 to provide an in-depth analysis of housing affordability after the recent housing market bust. The paper looks at affordability in the New England states, their largest metropolitan areas, competitor metropolitan areas, and for the nation. The results show that as New England's housing prices have declined, affordability has been returning to the pre-housing crisis ...

  19. Debt, jobs, or housing: what's keeping millennials at home?

    OpenAIRE

    Bleemer, Zachary; Brown, Meta; Lee, Donghoon; van der Klaauw, Wilbert

    2014-01-01

    Young Americans' residence choices have changed markedly over the past fifteen years, with recent cohorts entering the housing market at lower rates, and lingering much longer in parents' households. This paper begins with descriptive evidence on the residence choices of 1 percent of young Americans with credit reports, observed quarterly for fifteen years in the Federal Reserve Bank of New York's Equifax-sourced Consumer Credit Panel (CCP). Steep increases in the rate of living with parents ...

  20. The Missing Link in Housing Sector Reforms in Nigeria

    Directory of Open Access Journals (Sweden)

    Akintunde Otubu

    2012-09-01

    Full Text Available Housing is a fundamental product for every human being irrespective of financial standing. World acclaimed American psychologist, Abraham Maslow ranked shelter as second only to food in his hierarchy of human needs. Despite the importance of housing to the socio-economic development of man and the nation, housing problems have remained endemic throughout the world. In today’s world, some 100 million persons are homeless and more than a billion are inadequately housed. In 2002 housing deficit in Nigeria was put at about 8 million units. Latest statistics indicate that Nigeria requires a whopping 700,000 housing units annually for the next 15 years. The question is why this state of affairs? Why the perennial and unending problems of housing shortages, forced evictions and slum development? The paper examined these issues in Nigeria in order to advance the future prospect of the sector. The paper identified that whilst reforms were been made to all other subsector of the housing industry, land reform necessary to fast track the process was left unattended to by the government. The paper thus advocated for a robust reform of the current land management system in order to impact positively on the housing reform agenda in Nigeria.

  1. The Housing Bubble Fact Sheet

    OpenAIRE

    Dean Baker

    2005-01-01

    This paper explains the basic facts about the current housing market. It lays out the evidence that the rise in housing prices constitutes a housing bubble - and explains what can be expected when it inevitably collapses.

  2. Large Aperture Electrostatic Dust Detector

    International Nuclear Information System (INIS)

    Diagnosis and management of dust inventories generated in next-step magnetic fusion devices is necessary for their safe operation. A novel electrostatic dust detector, based on a fine grid of interlocking circuit traces biased to 30 or 50 v has been developed for the detection of dust particles on remote surfaces in air and vacuum environments. Impinging dust particles create a temporary short circuit and the resulting current pulse is recorded by counting electronics. Up to 90% of the particles are ejected from the grid or vaporized suggesting the device may be useful for controlling dust inventories. We report measurements of the sensitivity of a large area (5x5 cm) detector to microgram quantities of dust particles and review its applications to contemporary tokamaks and ITER.

  3. The House That Morgan Built

    OpenAIRE

    Trautmann, Thomas

    2013-01-01

    L.H. Morgan’s kinship work began and ended with the Iroquois longhouse, and the Iroquois kinship system that it shaped and by which it was shaped.  Kinship became a house for anthropology, shaping and being shaped by the emerging discipline.  Much of the house that Morgan built for anthropology still stands, including the last book, on houses and house-life, which seems to anticipate the current literature on houses and house-societies.

  4. Housing commissioning in the Netherlands

    OpenAIRE

    S. Maussen; Smits, M.

    2011-01-01

    Property developers in the Netherlands are responsible for 83% of de housing production in the profit and non-profit sector. At this moment the housing shortage is neutralized but there is still a quality mismatch between demand and supply on the Dutch housing market. In recent years, a new organizer of housing projects is becoming more popular within the development sector, the end users of the houses themselves. The Dutch government has taken initiative to expand housing production commissi...

  5. THE AMERICAN CULTURE WARS AND AMERICAN LITERATURE TEXTBOOKS IN CHINA

    Institute of Scientific and Technical Information of China (English)

    ZhouJingqiong

    2004-01-01

    The American Culture Wars have had a great impact on gender and racial relations in the US and have triggered the transformation of its literary canon. American literature textbooks in China. however, are not reaping the fruits of the US cultural debates, a conclusion based on a survey of eight popular textbooks recently published by prestigious publishing houses.Given the significance of the US sociopolitical base in shaping the canon and the lecturers' dependence on the textbooks, they need immediate and drastic improvement. The paper is rounded off with some cues on what to improve.

  6. Formation of Cosmic Dust Bunnies

    OpenAIRE

    Matthews, Lorin S.; Hayes, Ryan L.; Freed, Michael S.; Hyde, Truell W.

    2007-01-01

    Planetary formation is an efficient process now thought to take place on a relatively short astronomical time scale. Recent observations have shown that the dust surrounding a protostar emits more efficiently at longer wavelengths as the protoplanetary disk evolves, suggesting that the dust particles are coagulating into fluffy aggregates, "much as dust bunnies form under a bed." One poorly understood problem in this coagulation process is the manner in which micron-sized, charged grains form...

  7. Sustainable Housing Design

    DEFF Research Database (Denmark)

    Lauring, Gert Michael

    2016-01-01

    When designing sustainable housing, energy optimization and subsequently satisfactory indoor climates are central issues that need to be incorporated from early design phases if to reach a coherent design. At the same time it might be argued that energy used for running modern buildings only plays...... live in detached houses typically situated in less dense suburbia neighborhood to achieve safety and green space for kids to play and socialize. Thus, if one wants to realistically solve the issue of sustainable housing design one must address the intertwined aspects of building construction, urban...

  8. Dust Heating in Nearby Galaxies

    OpenAIRE

    Kong, Lingjie

    2013-01-01

    Dust is an important part of the interstellar medium (ISM). Dust absorbs ultravioletand optical star light and re-emits in the mid- and far-infrared light. More than onethird of the total star light in the universe is absorbed and re-emitted by dust.Observations show that dust emission is strongly correlated with star formationrates. Recent research with Herschel Space Observatory data has shown that dustemission at ≥ 250 µm appears to be heated by the total stellar population ratherthan just...

  9. Understanding the Transport of Patagonian Dust and Its Influence on Marine Biological Activity in the South Atlantic Ocean

    Science.gov (United States)

    Johnson, Matthew; Meskhidze, Nicholas; Kiliyanpilakkil, Praju; Gasso, Santiago

    2010-01-01

    Modeling and remote sensing techniques were applied to examine the horizontal and vertical transport pathways of Patagonian dust and quantify the effect of soluble-iron- laden mineral dust deposition on marine primary productivity in the South Atlantic Ocean (SAO) surface waters. The global chemistry transport model GEOS-Chem, implemented with an iron dissolution scheme, was applied to evaluate the atmospheric transport and deposition of mineral dust and bioavailable iron during two dust outbreaks originating in the source regions of Patagonia. In addition to this "rapidly released" iron, offline calculations were also carried out to estimate the amount of bioavailable iron leached during the residence time of dust in the ocean mixed layer. Model simulations showed that the horizontal and vertical transport pathways of Patagonian dust plumes were largely influenced by the synoptic meteorological patterns of high and low pressure systems. Model-predicted horizontal and vertical transport pathways of Patagonian dust over the SAO were in reasonable agreement with remotely-sensed data. Comparison between remotely-sensed and offline calculated ocean surface chlorophyll-a concentrations indicated that, for the two dust outbreaks examined in this study, the deposition of bioavailable iron in the SAO through atmospheric pathways was insignificant. As the two dust transport episodes examined here represent typical outflows of mineral dust from South American sources, our study suggests that the atmospheric deposition of mineral dust is unlikely to induce large scale marine primary productivity and carbon sequestration in the South Atlantic sector of the Southern Ocean.

  10. Jovian dust streams: A monitor of Io's volcanic plume activity

    Science.gov (United States)

    Kruger, H.; Geissler, P.; Horanyi, M.; Graps, A.L.; Kempf, S.; Srama, R.; Moragas-Klostermeyer, G.; Moissl, R.; Johnson, T.V.; Grun, E.

    2003-01-01

    Streams of high speed dust particles originate from Jupiter's moon Io. After release from Io, the particles collect electric charges in the Io plasma torus, gain energy from the co-rotating electric field of Jupiter's magnetosphere, and leave the Jovian system into interplanetary space with escape speeds over 200 km s-1. The Galileo spacecraft has continuously monitored the dust streams during 34 revolutions about Jupiter between 1996 and 2002. The observed dust fluxes exhibit large orbit-to-orbit variability due to systematic and stochastic changes. After removal of the systematic variations, the total dust emission rate of Io has been calculated. It varies between 10-3 and 10 kg s-1, and is typically in the range of 0.1 to 1 kg s-1. We compare the dust emission rate with other markers of volcanic activity on Io like large-area surface changes caused by volcanic deposits and sightings of volcanic plumes. Copyright 2003 by the American Geophysical Union.

  11. Housing Satisfaction of Older (55+) Single-Person Householders in U.S. Rural Communities.

    Science.gov (United States)

    Ahn, Mira; Lee, Sung-Jin

    2016-08-01

    This study aims to understand the housing satisfaction of older (55+) single-person householders in U.S. rural communities using the available variables from a secondary data set, the 2011 American Housing Survey (AHS). In this study, housing satisfaction was considered to be an indicator of quality of life. Based on previous studies, we developed a model to test a hypothesized relationship between older (55+) single-person householders' (N = 1,017) housing satisfaction and their personal, physical, financial, and environmental characteristics. Multiple regression results showed that the model was supported, indicating that significant variables in housing satisfaction include age, gender, health status, age of house, structure type, and unit location. Among the significant variables, health status was revealed to be the strongest factor in housing satisfaction. Housing satisfaction was discussed as potential indicators of quality of life. PMID:25846383

  12. Change of Regulatory Treg Cells Levels in Asthmatic Children Allergic to House Dust Mite and Its Clinical Significance%屋尘螨过敏的支气管哮喘患儿调节性T淋巴细胞水平变化及其临床意义

    Institute of Scientific and Technical Information of China (English)

    王炜; 李芳; 段国威; 吴晓玲; 宋青

    2012-01-01

    Objective To investigate the changes of frequency and function of CD4 + CD25 + Foxp3 +Treg cells and their roles in the evaluation of severity in children with asthma allergic to house dust mite( HDM). Methods Sixty children sensitive to HDM with asthma were divided into mild asthma group,moderate asthma group and severe asthma group according to their clinical features,and 20 healthy children were enrolled as the healthy control group. Peripheral Mood monouctear cells ( PBMC) were isolated from the subjects. After 48 hours of in vitro stimulation with HDM extracts, CD4 + CD25+ Foxp3 + regulatory T cells and CD4+ CD25 + Foxp3 + IL - 10+ regulatory T cells were measured by using flow cytometry. Results The frequency of CD4 + CD25+ Foxp3 + Treg cells had no statistical significance between the mild asthma group and moderate asthma group(P, >0.05) .but significantly decreased in the severe asthma group compared with the healthy control group(P <0.001). The frequency of IL - 10 - secreting - CD4 + CD25+ Foxp3 + Treg cells was also decreased significantly in the asthma group compared with that in the healthy control group( P <0.001). The frequency of IL - 10 - secreting - CD4 + CD25 + Foxp3 + Treg cells was significantly lower in the moderate asthma group compared with that in the mild asthma group(P<0.05) ,and the IL- 10 - secreting - CD4 + CD25 + Foxp3 + Treg cells in the severe asthma group were hardly found. The. frequency of IL - 10 - secreting - CD4 + CD25 + Foxp3 + Treg cells was significantly lower in the severe asthma group compared with that in the moderate asthma group( P<0.01). There was a remarkably negative correlation between IL - 10 - secreting - CD4 + CD25 + Foxp3 + Treg cells level and the asthma severity(r= -0. 637,P<0.05). Conclusions In the mild asthma children and moderate asthma children, there are quantitative but functional insufficiency of regulatory T cells. And in severe asthma group there are both quantitative and functional

  13. Dust deposition on the Mars Exploration Rover Panoramic Camera (Pancam) calibration targets

    Science.gov (United States)

    Kinch, K.M.; Sohl-Dickstein, J.; Bell, J.F., III; Johnson, J. R.; Goetz, W.; Landis, G.A.

    2007-01-01

    The Panoramic Camera (Pancam) on the Mars Exploration Rover mission has acquired in excess of 20,000 images of the Pancam calibration targets on the rovers. Analysis of this data set allows estimates of the rate of deposition and removal of aeolian dust on both rovers. During the first 150-170 sols there was gradual dust accumulation on the rovers but no evidence for dust removal. After that time there is ample evidence for both dust removal and dust deposition on both rover decks. We analyze data from early in both rover missions using a diffusive reflectance mixing model. Assuming a dust settling rate proportional to the atmospheric optical depth, we derive spectra of optically thick layers of airfall dust that are consistent with spectra from dusty regions on the Martian surface. Airfall dust reflectance at the Opportunity site appears greater than at the Spirit site, consistent with other observations. We estimate the optical depth of dust deposited on the Spirit calibration target by sol 150 to be 0.44 ?? 0.13. For Opportunity the value was 0.39 ?? 0.12. Assuming 80% pore space, we estimate that the dust layer grew at a rate of one grain diameter per ???100 sols on the Spirit calibration target. On Opportunity the rate was one grain diameter per ???125 sols. These numbers are consistent with dust deposition rates observed by Mars Pathfinder taking into account the lower atmospheric dust optical depth during the Mars Pathfinder mission. Copyright 2007 by the American Geophysical Union.

  14. Dust coagulation in ISM

    Science.gov (United States)

    Chokshi, Arati; Tielens, Alexander G. G. M.; Hollenbach, David

    1989-01-01

    Coagulation is an important mechanism in the growth of interstellar and interplanetary dust particles. The microphysics of the coagulation process was theoretically analyzed as a function of the physical properties of the coagulating grains, i.e., their size, relative velocities, temperature, elastic properties, and the van der Waal interaction. Numerical calculations of collisions between linear chains provide the wave energy in individual particles and the spectrum of the mechanical vibrations set up in colliding particles. Sticking probabilities are then calculated using simple estimates for elastic deformation energies and for the attenuation of the wave energy due to absorption and scattering processes.

  15. In-house (disability

    Directory of Open Access Journals (Sweden)

    Safak Pavey

    2010-07-01

    Full Text Available In May 2007 UNHCR established an internal working group to look at developing in-house policies for people with disabilities both for the benefit of people of concern to us and for staff members.

  16. Legislative Districts - House Districts

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This layer represents the Arkansas State House of Representatives district boundaries adopted by the Arkansas Board of Apportionment on July 29, 2011. The Board of...

  17. Creating housing opportunities

    OpenAIRE

    Josephine McNeil

    2007-01-01

    Helping families of low and moderate means find opportunities in high-cost areas requires special tactics. Citizens for Affordable Housing in Newton Development Organization (CAN-DO) shows it can be done.

  18. Rental Housing Finance Survey

    Data.gov (United States)

    Department of Housing and Urban Development — The purpose of the RHFS is to provide current and continuous measure of the financial health and property characteristics of single-family and multifamily rental...

  19. Residential metal contamination and potential health risks of exposure in adobe brick houses in Potosí, Bolivia.

    Science.gov (United States)

    McEwen, Abigail R; Hsu-Kim, Heileen; Robins, Nicholas A; Hagan, Nicole A; Halabi, Susan; Barras, Olivo; Richter, Daniel deB; Vandenberg, John J

    2016-08-15

    Potosí, Bolivia, is the site of centuries of historic and present-day mining of the Cerro Rico, a mountain known for its rich polymetallic deposits, and was the site of large-scale Colonial era silver refining operations. In this study, the concentrations of several metal and metalloid elements were quantified in adobe brick, dirt floor, and surface dust samples from 49 houses in Potosí. Median concentrations of total mercury (Hg), lead (Pb), and arsenic (As) were significantly greater than concentrations measured in Sucre, Bolivia, a non-mining town, and exceeded US-based soil screening levels. Adobe brick samples were further analyzed for bioaccessible concentrations of trace elements using a simulated gastric fluid (GF) extraction. Median GF extractable concentrations of Hg, As, and Pb were 0.085, 13.9, and 32.2% of the total element concentration, respectively. Total and GF extractable concentrations of Hg, As, and Pb were used to estimate exposure and potential health risks to children following incidental ingestion of adobe brick particles. Risks were assessed using a range of potential ingestion rates (50-1000mg/day). Overall, the results of the risk assessment show that the majority of households sampled contained concentrations of bioaccessible Pb and As, but not Hg, that represent a potential health risk. Even at the lowest ingestion rate considered, the majority of households exceeded the risk threshold for Pb, indicating that the concentrations of this metal are of particular concern. To our knowledge, this is the first study to quantify key trace elements in building materials in adobe brick houses and the results indicate that these houses are a potential source of exposure to metals and metalloids in South American mining communities. Additional studies are needed to fully characterize personal exposure and to understand potential adverse health outcomes within the community. PMID:27100004

  20. Housing Characteristics, 1990

    International Nuclear Information System (INIS)

    This report on energy consumption in the residential sector covers the following topics: housing trends 1980--1990, new housing trends, availability and usage of natural gas by households, changes in appliance usage (refrigerators, entertainment appliances, cooking appliances, convenience appliances), age of major household appliances and equipment, household energy conservation activities, demand-side management programs, and a portrait of households using solar or wood as a source of energy

  1. Concord Housing Blocks

    OpenAIRE

    Kumaraswamy, Mohan

    2002-01-01

    One element of the CIVCAL project Web-based resources containing images, tables, texts and associated data on the construction of Concord type Housing Blocks. A high rise public housing project using prefabriction and advanced formwork systems. Both Harmony and Concord Blocks are designed on the basis of standard modular flats which permit the use of factory produced components and a construction sequence which makes extensive use of advanced formwork systems.

  2. Betting the House

    OpenAIRE

    Jordà, Òscar; Schularick, Moritz; Taylor, Alan M.

    2014-01-01

    Is there a link between loose monetary conditions, credit growth, house price booms, and financial instability? This paper analyzes the role of interest rates and credit in driving house price booms and busts with data spanning 140 years of modern economic history in the advanced economies. We exploit the implications of the macroeconomic policy trilemma to identify exogenous variation in monetary conditions: countries with fixed exchange regimes often see fluctuations in short-term interest ...

  3. Evaluating House Price Forecasts

    OpenAIRE

    John M. Clapp; Carmelo Giaccotto

    2002-01-01

    House prices, unlike stock prices, appear to be predictable with some degree of accuracy. We use an autoregressive process to model the time series behavior of a city-wide house price index, and then produce one-quarter ahead forecasts for individual properties. Better real estate decisions require forecasting models with desirable properties for prediction errors (PEs). We propose that managers use a battery of tests to compare PEs; in particular, non-parametric smoothing of the empirical di...

  4. Spatial and temporal variations of dust concentrations in the Gobi Desert of Mongolia

    Science.gov (United States)

    Jugder, D.; Shinoda, M.; Sugimoto, N.; Matsui, I.; Nishikawa, M.; Park, S.; Chun, Y.; Park, M.

    2011-12-01

    Dust storms in the extensive Gobi and desert-steppe zones of Mongolia occur frequently and sometimes cause serious disasters. Dust storms progress from source regions to downstream regions. This study was the first to examine dust mass concentrations of PM10 (PM2.5) in the Gobi Desert, Mongolia. The monthly mean concentrations of PM10 (PM2.5) reached yearly maxima in December and January owing to air pollution. Both PM10 and PM2.5 concentrations were enhanced from March to May by dust storms. Large amounts of fine dust particles are emitted to the air during the dust storm period in the Gobi Desert of Mongolia. Daily mean concentrations of PM10 (PM2.5) varied 64~234 (40~115) μg m-3 for dust storms in spring. The highest hourly mean concentration of PM10 was 6626 μg m-3 in the Gobi during a dust storm. Averaged concentrations of PM10 (PM2.5) for more than 4h-duration periods of the dust events varied from 204 (101) μg m-3 to 452 (170) μg m-3. For diurnal variations, the maximum PM10 (PM2.5) concentrations occurred in the morning and evening, coinciding with coal usage in private houses. It is evident that human activities can affect local air quality around urban localities in the Gobi of Mongolia. Afternoon peaks in PM10 (PM2.5) concentrations appear to be due to dust storms. Study results on the temporal and spatial distributions and transportation of dust storms, and elevated dust by using Polarization-sensitive Mie-scattering lidars showed that the maximum height of dusty layers over the Gobi Desert of Mongolia during dust storm periods varied from 0.5 to 5.5 km above ground level. The Mie lidar observations detected the base and top heights of elevated dust layers transported from other source regions to the Gobi Desert. The study results suggest source areas of the elevated dust. The lidar parameters showed annual variation of dust storms with higher frequencies in March to May.

  5. Synthetic Phenolic Antioxidants and Their Metabolites in Indoor Dust from Homes and Microenvironments.

    Science.gov (United States)

    Wang, Wei; Asimakopoulos, Alexandros G; Abualnaja, Khalid O; Covaci, Adrian; Gevao, Bondi; Johnson-Restrepo, Boris; Kumosani, Taha A; Malarvannan, Govindan; Minh, Tu Binh; Moon, Hyo-Bang; Nakata, Haruhiko; Sinha, Ravindra K; Kannan, Kurunthachalam

    2016-01-01

    Synthetic phenolic antioxidants (SPAs), including 2,6-di-tert-butyl-4-hydroxytoluene (BHT), are extensively used in food, cosmetic and plastic industries. Nevertheless, limited information is available on human exposures, other than the dietary sources, to SPAs. In this study, occurrence of 9 SPAs and their metabolites/degradation products was determined in 339 indoor dust collected from 12 countries. BHT was found in 99.5% of indoor dust samples from homes and microenvironments at concentrations that ranged from BHT metabolites in house dust (0.01-35.1 μg/g) and their concentrations accounted for 9.2-58% of the sum concentrations (∑SPAs). 3,5-di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO), 2,6-di-tert-butyl-4-(hydroxymethyl)phenol (BHT-OH), 2,6-di-tert-butyl-1,4-benzoquinone (BHT-Q) were the major derivatives of BHT found in dust samples. The concentrations of gallic acid esters (gallates) in dust from homes and microenvironments ranged from BHT via house dust ingestion ranged from 0.40 to 222 ng/kg/d (95th percentile). PMID:26629709

  6. Housing in Los Angeles: Affordable Housing for the Future.

    Science.gov (United States)

    Los Angeles Blue Ribbon Committee for Affordable Housing, CA.

    A 1988 mayoral committee assessed the seriousness of Los Angeles (California) housing problems and found that the city's housing efforts were sufficient in the 1960s, when the Federal Government took primary responsibility for housing and the average wage was adequate to support the cost of the average house or apartment. However, the following…

  7. Passive houses in Norway

    Energy Technology Data Exchange (ETDEWEB)

    Halse, Andreas

    2008-12-15

    The paper analyzes the introduction of passive houses in the Norwegian house market. Passive houses are houses with extremely low levels of energy consumption for heating, and have not yet been built in Norway, but have started to enter the market in Germany and some other countries. The construction sector is analyzed as a sectoral innovation system. The different elements of the innovation system are studied. This includes government agencies, producers, consumers, finance and education. The analysis shows that passive and low-energy houses are on the verge of market breakthrough. This can partly be explained by economic calculations, and partly by processes of learning and change in the institutional set-up of the sector. The construction sector is a sector characterized by low innovative intensity and little interaction between different agents. Those working to promote passive houses have to some extent managed to cope with these challenges. This has happened by breaking away from the traditional focus of Norwegian energy efficiency policies on technology and the economically rational agents, by instead focusing on knowledge and institutional change at the level of the producers. (Author)

  8. Hazards of explosives dusts: Particle size effects

    Energy Technology Data Exchange (ETDEWEB)

    Cashdollar, K L; Hertzberg, M; Green, G M

    1992-02-01

    At the request of the Department of Energy, the Bureau of Mines has investigated the hazards of military explosives dispersed as dust clouds in a 20-L test chamber. In this report, the effect of particle size for HMX, HNS, RDX, TATB, and TNT explosives dusts is studied in detail. The explosibility data for these dusts are also compared to those for pure fuel dusts. The data show that all of the sizes of the explosives dusts that were studied were capable of sustaining explosions as dust clouds dispersed in air. The finest sizes (<10 [mu]m) of explosives dusts were less reactive than the intermediate sizes (20 to 60 [mu]m); this is opposite to the particle size effect observed previously for the pure fuel dusts. At the largest sizes studied, the explosives dusts become somewhat less reactive as dispersed dust clouds. The six sizes of the HMX dust were also studied as dust clouds dispersed in nitrogen.

  9. Analyze the Book The House on Mango Street

    Institute of Scientific and Technical Information of China (English)

    王昭昭

    2013-01-01

    The House on Mango Street is a coming-of-age novel by Mexican-American writer Sandra Cisneros, published in 1984. In this book Esperanza is determined to"say goodbye"to the Mango Street. The novel is a group of lyric prose dedicate to memory, and it is also a girl’s diary recorded her grow up experiences.

  10. 78 FR 8551 - Federal Housing Administration (FHA) Risk Management Initiatives: Changes to Maximum Loan-to...

    Science.gov (United States)

    2013-02-06

    ...'s annual Fiscal Year 2012 report to Congress on the financial status of the FHA Mutual Mortgage... improve the health of the MMIF, while ensuring continued access to mortgage credit for American families... housing crisis, and the volume of FHA insurance increased rapidly during the housing crisis as...

  11. Charged Dust Aggregate Interactions

    Science.gov (United States)

    Matthews, Lorin; Hyde, Truell

    2015-11-01

    A proper understanding of the behavior of dust particle aggregates immersed in a complex plasma first requires a knowledge of the basic properties of the system. Among the most important of these are the net electrostatic charge and higher multipole moments on the dust aggregate as well as the manner in which the aggregate interacts with the local electrostatic fields. The formation of elongated, fractal-like aggregates levitating in the sheath electric field of a weakly ionized RF generated plasma discharge has recently been observed experimentally. The resulting data has shown that as aggregates approach one another, they can both accelerate and rotate. At equilibrium, aggregates are observed to levitate with regular spacing, rotating about their long axis aligned parallel to the sheath electric field. Since gas drag tends to slow any such rotation, energy must be constantly fed into the system in order to sustain it. A numerical model designed to analyze this motion provides both the electrostatic charge and higher multipole moments of the aggregate while including the forces due to thermophoresis, neutral gas drag, and the ion wakefield. This model will be used to investigate the ambient conditions leading to the observed interactions. This research is funded by NSF Grant 1414523.

  12. Of data and dust

    CERN Multimedia

    Stephanie Hills

    2016-01-01

    The traditional image of an archive is one of dusty old boxes, books and papers. When your archive is digital, dust spells disaster. An innovative environmental sensor designed and built by a CERN IT specialist has become an essential element in the Laboratory’s data-preservation strategy.   The novel air particle monitoring sensor designed by CERN's Julien Leduc. CERN’s archive holds more than 130 petabytes of data from past and present high-energy physics experiments. Some of it is 40 years old, most of it needs to be kept forever, and all of it is held on tape cartridges (over 20,000 of them). The cartridges are held inside tape libraries with robotic arms that load them into tape drives where they can be read and written. Tape cartridges have many advantages over other data storage media, notably cost and long-term reliability, but topping the list of drawbacks is their vulnerability to contamination from airborne dust particles; a tiny piece of g...

  13. IMPACT OF THE ECOLOGICAL TREND UPON HOUSE BUILDING

    Directory of Open Access Journals (Sweden)

    Adelaida Cristina HONTUS

    2013-08-01

    Full Text Available The American and Romanian house market has imposed harmonious and comfortable living in ecological houses whose building does not affect the environment. The implementation of modern and efficient building of long-term sustainable houses has resulted in a new ecological building technology by the Wood Framing System which is developed and applied on a large scale in the US. This system is a cheap and accessible method to build houses and preserve them in time, as well as provide all the comfort demands. Also, the houses built within this system are adapted to any architecture style (traditional, contemporary, and futurist.The house structures built within the Wood Framing System are conspicuous through the optimum use of the wooden material, resistance, stability, ductility, low weight which thus reduces the earthquake impact, durability, high thermal comfort, competitive price. At the same time, the building time on the site is up to 70% lower, compared with the brick-based houses.Within the framing system, a wooden-structure house provides important advantages, and thus has become of interest on the Romanian market.

  14. Influence of Lifestyle on Housing Preferences of Multifamily Housing Residents

    OpenAIRE

    Lee, Hyun-Jeong

    2005-01-01

    Lifestyle is a popular concept used to understand consumers' behaviors; however, the lifestyle concept rarely has been applied to housing studies. Although renting a multifamily dwelling is a non-normative housing choice in the United States, many people prefer to rent multifamily housing units for reasons other than financial. The purpose of this study is to identify the housing preferences of multifamily housing residents as determined by their lifestyles. The model of influences on ho...

  15. Housing accessibility and housing policy in Ljubljana: A comparative perspective

    OpenAIRE

    Srna Mandič

    2007-01-01

    The focus of the article is on access to housing and the conceptual basis for its analysis and understanding in contemporary Slovenian society. First the housing outcomes of the process of “transition” are highlighted, still causing unfavourable conditions in the system of housing provision. This is followed by an overview of the discussion of housing deprivation, vulnerability and homelessness in the context of contemporary EU policy making. Finally the issue of housing deprivation is discus...

  16. HOUSING AND HOUSING FINANCIAL INSTITUTIONS IN THE CONTEXT OF ETHIOPIANS

    OpenAIRE

    Dr M Moses Antony Rajendran

    2013-01-01

    Housing is an essential human need. The need for housing will therefore exist, as long as human beings exist in the world. It is in this contest that house financing plays a key role in providing the necessary financial assistance for construction, extension and modification of housing. Provision of basic housing facility has been one of the priorities of developing countries. International financing agencies such as the World Bank is providing all the facilities and assistance to the country...

  17. 75 FR 32142 - Combustible Dust

    Science.gov (United States)

    2010-06-07

    ... combustible dust in the workplace. (74 FR 54334, Oct. 21, 2009). OSHA plans to use the information received in... Secretary's Order 5-2007 (72 FR 31160). Signed at Washington, DC, on June 1, 2010. David Michaels, Assistant... Occupational Safety and Health Administration 29 CFR Part 1910 RIN 1218-AC41 Combustible Dust...

  18. 75 FR 10739 - Combustible Dust

    Science.gov (United States)

    2010-03-09

    ... for combustible dust. (74 FR 54334, Oct. 21, 2009) II. Stakeholder Meetings OSHA conducted two... (72 FR 31160). Signed at Washington, DC, on March 2, 2010. David Michaels, Assistant Secretary of... Occupational Safety and Health Administration 29 CFR Part 1910 RIN 1218-AC41 Combustible Dust...

  19. Dust particle charging in sheath

    International Nuclear Information System (INIS)

    The charging and the screening of spherical dust particles in sheaths near the wall were studied using computer simulation. The three-dimensional PIC/MCC method and molecular dynamics method were applied to describe plasma particles motion and interaction with macroscopic dust grain. Calculations were carried out at different neutral gas pressures and wall potentials. Values of the charge of the dust particles and spatial distributions of plasma parameters are obtained by modelling. The results have shown that the charge of the dust particles in the sheath, as well as the spatial distribution of the ions and electrons near the dust particles, depend strongly on the wall potential. It is shown that for large negative values of the wall potential the negative charge of a dust particle decreases due to the decline of the electron density in its vicinity. In addition, the flow of energy of the ions on the surface of dust particles is increased due to better focusing effect of the dust particle field on ions.

  20. Health hazards of cement dust

    International Nuclear Information System (INIS)

    ven in the 21st century, millions of people are working daily in a dusty environment. They are exposed to different types of health hazards such as fume, gases and dust, which are risk factors in developing occupational disease. Cement industry is involved in the development of structure of this advanced and modern world but generates dust during its production. Cement dust causes lung function impairment, chronic obstructive lung disease, restrictive lung disease, pneumoconiosis and carcinoma of the lungs, stomach and colon. Other studies have shown that cement dust may enter into the systemic circulation and thereby reach the essentially all the organs of body and affects the different tissues including heart, liver, spleen, bone, muscles and hairs and ultimately affecting their micro-structure and physiological performance. Most of the studies have been previously attempted to evaluate the effects of cement dust exposure on the basis of spirometry or radiology, or both. However, collective effort describing the general effects of cement dust on different organ and systems in humans or animals, or both has not been published. Therefore, the aim of this review is to gather the potential toxic effects of cement dust and to minimize the health risks in cement mill workers by providing them with information regarding the hazards of cement dust. (author)

  1. American Nightmare: A Decade of Homelessness in the United States.

    Science.gov (United States)

    National Coalition for the Homeless, Washington, DC.

    A 1989 national survey of the dimensions of homelessness found that at least three million Americans are homeless and that the shortage of affordable housing was cited as the chief cause. Information was gathered from a telephone survey of emergency shelter providers, housing advocacy organizations, and local governments in 26 communities, ranging…

  2. Further Analysis on the Mystery of the Surveyor III Dust Deposits

    Science.gov (United States)

    Metzger, Philip; Hintze, Paul; Trigwell, Steven; Lane, John

    2011-01-01

    The Apollo 12 lunar module (LM) landing near the Surveyor 1lI spacecraft at the end of 1969 has remained the primary experimental verification of the predicted physics of plume ejecta effects from a rocket engine interacting with the surface of the moon. This was made possible by the return of the Surveyor 1lI camera housing by the Apollo 12 astronauts, allowing detailed analysis of the composition of dust deposited by the Apollo 12 LM plume. It was soon realized after the initial analysis of the camera housing that the LM plume tended to remove more dust than it had deposited. In the present study, coupons from the camera housing were reexamined by a KSC research team using SEM/EDS and XPS analysis. In addition, plume effects recorded in landing videos from each Apollo mission have been studied for possible clues. Several likely scenarios are proposed to explain the Surveyor III dust observations. These include electrostatic attraction of the dust to the surface of the Surveyor as a result of electrostatic charging of the jet gas exiting the engine nozzle during descent; dust blown by the Apollo 12 LM fly-by while on its descent trajectory; dust ejected from the lunar surface due to gas forced into the soil by the Surveyor 1lI rocket nozzle, based on Darcy's law; and mechanical movement of dust during the Surveyor landing. Even though an absolute answer is not possible based on available data and theory, various computational models are employed to estimate the feasibility of each of these proposed mechanisms. Scenarios are then discussed which combine multiple mechanisms to produce results consistent with observations.

  3. Dust and the Sick Building Syndrome

    DEFF Research Database (Denmark)

    Gyntelberg, Finn; Suadicani, Poul; Wohlfahrt Nielsen, Jan; Skov, Peder; Valbjørn, Ole; Nielsen, Peter A.; Schneider, Thomas; Jørgensen, Ole; Wolkoff, Peder; Wilkins, C. K.; Gravesen, Suzanne; Norn, Svend

    Farmakologi, bacteria, dust, histamine, disease, gram-negative, indoor climate, sick building syndrome......Farmakologi, bacteria, dust, histamine, disease, gram-negative, indoor climate, sick building syndrome...

  4. Bi-dust acoustic waves

    Energy Technology Data Exchange (ETDEWEB)

    Martin, P.; Castro, E.; Puerta, J. [Universidad Simon Bolivar, Apartado 89000, Caracas 1080A (Venezuela); Valdeblanquez, E. [Universidad del Zulia, facultad de Ingenieria, Apartado 4011-A 526, Maracaibo, Edo. Zulia (Venezuela)

    2006-07-01

    Low frequencies waves in plasmas with two kind of dusty grains have been studied. Each species of dust particle is characterized by the grain radius, which determines its equilibrium charge. Relative velocities between the two kinds of dust grain for the unperturbed plasma is also considered in order to study instabilities and compare with astrophysical and industrial applications. In this analysis, each dust species is handled with a simplified model of kinetic-fluid equations, and the electrons and ions are determined by Boltzmann factors. The low frequency dispersion relation for bi-dust plasma waves with non relative motion between each kind of grain leads to damped waves with two characteristic frequencies. Instabilities are produced by the relative motion between the species. The onset of these instabilities is studied as a function of the plasma dust frequencies and relative velocities among each species. (Author)

  5. Passive House Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Strom, I.; Joosten, L.; Boonstra, C. [DHV Sustainability Consultants, Eindhoiven (Netherlands)

    2006-05-15

    PEP stands for 'Promotion of European Passive Houses' and is a consortium of European partners, supported by the European Commission, Directorate General for Energy and Transport. In this working paper an overview is given of Passive House solutions. An inventory has been made of Passive House solutions for new build residences applied in each country. Based on this, the most common basic solutions have been identified and described in further detail, including the extent to which solutions are applied in common and best practice and expected barriers for the implementation in each country. An inventory per country is included in the appendix. The analysis of Passive House solutions in partner countries shows high priority with regard to the performance of the thermal envelope, such as high insulation of walls, roofs, floors and windows/ doors, thermal bridge-free construction and air tightness. Due to the required air tightness, special attention must be paid to indoor air quality through proper ventilation. Finally, efficient ((semi-)solar) heating systems for combined space and DHW heating still require a significant amount of attention in most partner countries. Other basic Passive House solutions show a smaller discrepancy with common practice and fewer barriers have been encountered in partner countries. In the next section, the general barriers in partner countries have been inventoried. For each type of barrier a suggested approach has been given. Most frequently encountered barriers in partner countries are: limited know-how; limited contractor skills; and acceptation of Passive Houses in the market. Based on the suggested approaches to overcoming barriers, this means that a great deal of attention must be paid to providing practical information and solutions to building professionals, providing practical training to installers and contractors and communication about the Passive House concept to the market.

  6. Evaluation of dust respirators for elimination of mouse aeroallergens.

    Science.gov (United States)

    Sakaguchi, M; Inouye, S; Miyazawa, H; Kamimura, H; Kimura, M; Yamazaki, S

    1989-01-01

    The efficiency of various dust respirators for eliminating mouse allergens [mouse urine proteins (MUP), pelts proteins (MPP) and serum albumin (MSA)] were evaluated with use of low-volume air samplers and immunochemical methods. Three kinds of dust respirators from one manufacturer which have different efficacy in the exclusion of dust particles were put on the fiber glass filter in each air sampler. Then the air in a mouse housing room was sampled. The allergens passed through the respirators, were trapped in the fiber glass filters, and then extracted from the filters. The allergens of MUP and MPP in the extract were measured by an inhibition method of fluorometric enzyme-linked immunosorbent assay (ELISA) for IgE antibody and those of MSA measured by a fluorometric sandwich ELISA. The respirator with the lowest capability of exclusion was found to eliminate 65-86% of respective allergens. The other two respirators with higher powers eliminated 98% of MUP. MPP and MSA were eliminated to undetectable levels through these respirators. This study provided a means for the evaluation of dust respirators for animal aeroallergens. PMID:2918688

  7. Social Housing Provision in Copenhagen

    DEFF Research Database (Denmark)

    Tsenkova, Sasha; Vestergaard, Hedvig

    The paper provides an overview of trends and processes of change affecting new social housing provision in Denmark with a focus on Copenhagen. The local responses are reviewed within the context of changes to the unitary national housing system that functions with a robust range of private and non...... outcomes are evaluated through a series of indicators related to housing quality; stability of investment and production; differentiation of rents; affordability and choice. The research also identifies development strategies for new social housing provision developed by housing associations in the context......-profit housing providers, and a wide range of fiscal and regulatory instruments enhancing the competitive performance of the social housing sector. The research analyses recent housing policy measures and their impact on new social housing provision in Copenhagen. The emphasis is on the mix of housing policy...

  8. Dust in protoplanetary disks: observations*

    Directory of Open Access Journals (Sweden)

    Waters L.B.F.M.

    2015-01-01

    Full Text Available Solid particles, usually referred to as dust, are a crucial component of interstellar matter and of planet forming disks surrounding young stars. Despite the relatively small mass fraction of ≈1% (in the solar neighborhood of our galaxy; this number may differ substantially in other galaxies that interstellar grains represent of the total mass budget of interstellar matter, dust grains play an important role in the physics and chemistry of interstellar matter. This is because of the opacity dust grains at short (optical, UV wavelengths, and the surface they provide for chemical reactions. In addition, dust grains play a pivotal role in the planet formation process: in the core accretion model of planet formation, the growth of dust grains from the microscopic size range to large, cm-sized or larger grains is the first step in planet formation. Not only the grain size distribution is affected by planet formation. Chemical and physical processes alter the structure and chemical composition of dust grains as they enter the protoplanetary disk and move closer to the forming star. Therefore, a lot can be learned about the way stars and planets are formed by observations of dust in protoplanetary disks. Ideally, one would like to measure the dust mass, the grain size distribution, grain structure (porosity, fluffiness, the chemical composition, and all of these as a function of position in the disk. Fortunately, several observational diagnostics are available to derive constrains on these quantities. In combination with rapidly increasing quality of the data (spatial and spectral resolution, a lot of progress has been made in our understanding of dust evolution in protoplanetary disks. An excellent review of dust evolution in protoplanetary disks can be found in Testi et al. (2014.

  9. Dust in protoplanetary disks: observations

    Science.gov (United States)

    Waters, L. B. F. M.

    2015-09-01

    Solid particles, usually referred to as dust, are a crucial component of interstellar matter and of planet forming disks surrounding young stars. Despite the relatively small mass fraction of ≈1% (in the solar neighborhood of our galaxy; this number may differ substantially in other galaxies) that interstellar grains represent of the total mass budget of interstellar matter, dust grains play an important role in the physics and chemistry of interstellar matter. This is because of the opacity dust grains at short (optical, UV) wavelengths, and the surface they provide for chemical reactions. In addition, dust grains play a pivotal role in the planet formation process: in the core accretion model of planet formation, the growth of dust grains from the microscopic size range to large, cm-sized or larger grains is the first step in planet formation. Not only the grain size distribution is affected by planet formation. Chemical and physical processes alter the structure and chemical composition of dust grains as they enter the protoplanetary disk and move closer to the forming star. Therefore, a lot can be learned about the way stars and planets are formed by observations of dust in protoplanetary disks. Ideally, one would like to measure the dust mass, the grain size distribution, grain structure (porosity, fluffiness), the chemical composition, and all of these as a function of position in the disk. Fortunately, several observational diagnostics are available to derive constrains on these quantities. In combination with rapidly increasing quality of the data (spatial and spectral resolution), a lot of progress has been made in our understanding of dust evolution in protoplanetary disks. An excellent review of dust evolution in protoplanetary disks can be found in Testi et al. (2014). 2nd Lecture of the Summer School "Protoplanetary Disks: Theory and Modelling Meet Observations"

  10. Acute effect of glucan-spiked office dust on nasal and pulmonary inflammation in guinea pigs

    DEFF Research Database (Denmark)

    Straszek, Sune; Adamcakova-Dodd, Andrea; Nervana, Metwali; Pedersen, Ole Finn; Sigsgaard, Torben; Thorne, Peter Sherman

    2007-01-01

    The acute effects of pure inhaled glucan on respiratory inflammation remain inconclusive and not sufficiently examined with regards to the simultaneous interaction of glucan, endotoxin (LPS) and house dust in airway inflammation. This study aims at determining effects of simultaneous exposure to...... by acoustic rhinometry (AR) and animals were exposed by inhalation for 4 hr to curdlan spiked dust, unspiked dust, purified air (negative controls) or LPS (positive controls). After exposure (+5 hr) or the following day (+18 hr) measurements were repeated by AR and followed by bronchoalveolar lavage...... (BAL). Total and differential cell counts, IL-8 in BAL fluid and change in nasal volume was compared between groups. A 5-10% increase in nasal volume was seen for all groups including clean air except for a significant 5% decrease for spiked-dust inhalation (+18 hr). No marked differences were observed...

  11. Housing Dynamics: Theory Behind Empirics

    OpenAIRE

    Wang, Ping; Xie, Danyang

    2014-01-01

    We construct a dynamic general equilibrium model of housing, incorporating some key features that bridge time and space. We model explicitly the evolution of housing structures/household durables and the separate role played by land, fully accounting for households’ locational choice decisions. Housing services derive positive utility, but are decayed away from the city center. Our model enables a full characterization of the dynamic paths of housing as well as housing and land prices. The mo...

  12. The Martian Dust Cycle: Observations and Modeling

    Science.gov (United States)

    Kahre, Melinda A.

    2013-01-01

    The dust cycle is critically important for Mars' current climate system. Suspended atmospheric dust affects the radiative balance of the atmosphere, and thus greatly influences the thermal and dynamical state of the atmosphere. Evidence for the presence of dust in the Martian atmosphere can be traced back to yellow clouds telescopically observed as early as the early 19th century. The Mariner 9 orbiter arrived at Mars in November of 1971 to find a planet completely enshrouded in airborne dust. Since that time, the exchange of dust between the planet's surface and atmosphere and the role of airborne dust on Mars' weather and climate has been studied using observations and numerical models. The goal of this talk is to give an overview of the observations and to discuss the successes and challenges associated with modeling the dust cycle. Dust raising events on Mars range in size from meters to hundreds of kilometers. During some years, regional storms merge to produce hemispheric or planet encircling dust clouds that obscure the surface and raise atmospheric temperatures by tens of kelvin. The interannual variability of planet encircling dust storms is poorly understood. Although the occurrence and season of large regional and global dust storms are highly variable from one year to the next, there are many features of the dust cycle that occur year after year. A low-level dust haze is maintained during northern spring and summer, while elevated levels of atmospheric dust occur during northern autumn and winter. During years without global-scale dust storms, two peaks in total dust loading are generally observed: one peak occurs before northern winter solstice and one peak occurs after northern winter solstice. Numerical modeling studies attempting to interactively simulate the Martian dust cycle with general circulation models (GCMs) include the lifting, transport, and sedimentation of radiatively active dust. Two dust lifting processes are commonly represented in

  13. American ginseng

    Science.gov (United States)

    ... Some research suggests that taking a specific American ginseng extract called CVT-E002 (Cold-FX, Afexa Life Sciences, ... AD-fX, Afexa Life Sciences, Canada) containing American ginseng extract in combination with ginkgo leaf extract might help ...

  14. Domotics Project Housing Block

    Directory of Open Access Journals (Sweden)

    Carlos Morón

    2016-05-01

    Full Text Available This document develops the study of an implementation project of a home automation system in a housing placed in the town of Galapagar, Madrid. This house, which is going to be occupied by a four-member family, consists of 67 constructed square meters distributed in lounge, kitchen, three bedrooms, bath, bathroom and terrace, this being a common arrangement in Spain. Thus, this study will allow extracting conclusions about the adequacy of the home automation in a wide percentage of housing in Spain. In this document, three house automation proposals are developed based on the requirements of the client and the different home automation levels that the Spanish House and Building Automation Association has established, besides two parallel proposals relating to the safety and the technical alarms. The mentioned proposed systems are described by means of product datasheets and descriptions, distribution plans, measurements, budgets and flow charts that describe the functioning of the system in every case. An evaluation of each system is included, based on other studies conclusions on this matter, where expected energy savings from each design, depending on the current cost of lighting, water and gas, as well as the expected economic amortization period is evaluated.

  15. Domotics Project Housing Block.

    Science.gov (United States)

    Morón, Carlos; Payán, Alejandro; García, Alfonso; Bosquet, Francisco

    2016-01-01

    This document develops the study of an implementation project of a home automation system in a housing placed in the town of Galapagar, Madrid. This house, which is going to be occupied by a four-member family, consists of 67 constructed square meters distributed in lounge, kitchen, three bedrooms, bath, bathroom and terrace, this being a common arrangement in Spain. Thus, this study will allow extracting conclusions about the adequacy of the home automation in a wide percentage of housing in Spain. In this document, three house automation proposals are developed based on the requirements of the client and the different home automation levels that the Spanish House and Building Automation Association has established, besides two parallel proposals relating to the safety and the technical alarms. The mentioned proposed systems are described by means of product datasheets and descriptions, distribution plans, measurements, budgets and flow charts that describe the functioning of the system in every case. An evaluation of each system is included, based on other studies conclusions on this matter, where expected energy savings from each design, depending on the current cost of lighting, water and gas, as well as the expected economic amortization period is evaluated. PMID:27223285

  16. Ensuring Healthy American Indian Generations for Tomorrow through Safe and Healthy Indoor Environments

    Directory of Open Access Journals (Sweden)

    Joseph A. Pacheco

    2015-03-01

    Full Text Available American Indians (AI have the highest rate of severe physical housing problems in the U.S. (3.9%. Little information exists about the environmental hazards in AI homes. The purposes of this paper are to discuss challenges that were encountered when recruiting AI for a home-and employment-based environmental health assessments, highlight major successes, and propose recommendations for future indoor environmental health studies. The Center for American Indian Community Health (CAICH and Children’s Mercy Hospital’s Center for Environmental Health and Allergy and Immunology Research Lab collaborated to provide educational sessions and healthy home assessments for AI. Through educational trainings, more than 240 AI were trained on the primary causes of health problems in homes. A total of 72 homes and places of employment were assessed by AI environmental health specialists. The top three categories with the most concerns observed in the homes/places of employment were allergens/dust (98%, safety/injury (89% and chemical exposure (82%. While some information on smoking inside the home was collected, these numbers may have been underreported due to stigma. This was CAICH’s first endeavor in environmental health and although challenges arose, many more successes were achieved.

  17. La Lever house, New York

    Directory of Open Access Journals (Sweden)

    Sergio de Miguel

    2012-12-01

    Full Text Available

    Resumen

    En el último siglo la mítica ciudad de Nueva York ha sido capaz de definir y transmitir las más contagiosas propuestas de  construcción del futuro.
    El edificio de la Lever House, erigido en el corazón de Manhattan al comienzo de la prodigiosa década de los cincuenta, consiguió ser la constatación de que el perseguido sueño de la “torre de cristal” era por fin posible. La poética y secular conquista de la  levedad avanzó entonces a través de un prosaico y paradójico objeto publicitario. Un particular crisol de negocio, oportunidad y audacia hicieron de ésta sorprendente pieza un icono   fundamental de la globalizada arquitectura moderna americana.


    Nota* En la edición electrónica este artículo se ha publicado con toda documentación gráfica aportada por el autor.

    Palabras clave

    Lever house, torre, levedad, cristal, publicidad, icono

    Abstract

    In the last century, the mythical city of New York has been able to define and transmit the most contagious proposals of  innovative construction.
    The Lever House Building, erected in the heart of Manhattan at  the start of the prodigious 1950s managed to become a  statement for the possibility of finally realizing the sought‐after
    dream of building a glass tower. The poetics and secular   conquest of lightness therefore made a leap forward through a prosaic and paradoxical publicity item. A special crucible of business, opportunity and audacity made a fundamental icon of globalized modern American Architecture out of this surprising work.


    Note * In the online edition this article is published with all graphic material provided by the author.

  18. Dust jets produced by a dust-discharge instability

    International Nuclear Information System (INIS)

    We report observations of an instability that occurs in a dc glow discharge (anodic plasma) dusty plasma when a floating plate with a 5 mm aperture is placed in front of the anode. The instability is characterized by periodic quenching and reignition of the discharge. When the discharge is quenched, the dust is ejected from the aperture at speeds on the order of the dust-acoustic speed. The ejected dust remains partially charged and retracts back to the aperture when the discharge spontaneously redevelops.

  19. Regular spherical dust spacetimes

    CERN Document Server

    Humphreys, N; Matravers, D R; Humphreys, Neil; Maartens, Roy; Matravers, David

    1998-01-01

    Physical (and weak) regularity conditions are used to determine and classify all the possible types of spherically symmetric dust spacetimes in general relativity. This work unifies and completes various earlier results. The junction conditions are described for general non-comoving (and non-null) surfaces, and the limits of kinematical quantities are given on all comoving surfaces where there is Darmois matching. We show that an inhomogeneous generalisation of the Kantowski-Sachs metric may be joined to the Lemaitre-Tolman-Bondi metric. All the possible spacetimes are explicitly divided into four groups according to topology, including a group in which the spatial sections have the topology of a 3-torus. The recollapse conjecture (for these spacetimes) follows naturally in this approach.

  20. Lepidoglyphus destructor acarus in the urban house environment.

    Science.gov (United States)

    Juliá, J C; Martorell, A; Ventas, P; Cerdá, J C; Torró, I; Carreira, J; Guinot, E; Sanz, J; Alvarez, V

    1995-01-01

    To assess the presence of Lepidoglyphus destructor in the household environment of sensitized children living in an urban environment, samples of house dust were collected at the homes where two groups of patients were living, as well as in two bakeries in the city of Valencia, which were taken as a reference. Patients were divided into two groups. Group A included atopic children suffering from rhinitis and/or asthma, who were sensitized to L. destructor, as proven by prick test and specific IgE (CAP). Group B included children with the same features as those included in Group A, who were sensitized to Dermatophagoides pteronyssinus, with prick and CAP tests showing no significant sensitization to L. destructor. The samples of dust were analyzed, and the amounts of Der p I, Der f I, Der II and Lep d I per gram of dust were assessed through a solid-phase ELISA with monoclonal antibodies. In Group A, all patients but two showed a sensitization to D. pteronyssinus by prick test and serum IgE. At the homes of the patients from both groups, significant levels of Dermatophagoides were found. In Group A, only three houses showed levels of L. destructor which were comparable to those found in bakeries. Lep d I was not found in the houses of Group B patients. This means that a sensitization to L. destructor, as assessed with full extracts, is not always an indicator of its presence at the patient's house environment; it may rather refer to cross-reactivity to Dermatophagoides. Thus, availability of the main antigen Lep d I seems necessary to increase the specificity of the allergologic study. PMID:8653218

  1. Numerical simulation of "An American Haboob"

    Directory of Open Access Journals (Sweden)

    A. Vukovic

    2013-10-01

    Full Text Available A dust storm of fearful proportions hit Phoenix in the early evening hours of 5 July 2011. This storm, an American haboob, was predicted hours in advance because numerical, land-atmosphere modeling, computing power and remote sensing of dust events have improved greatly over the past decade. High resolution numerical models are required for accurate simulation of the small-scales of the haboob process, with high velocity surface winds produced by strong convection and severe downbursts. Dust productive areas in this region consist mainly of agricultural fields, with soil surfaces disturbed by plowing and tracks of land in the high Sonoran desert laid barren by ongoing draught. Model simulation of the 5 July 2011 dust storm uses the coupled atmospheric-dust model NMME-DREAM with 3.5 km horizontal resolution. A mask of the potentially dust productive regions is obtained from the land cover and the Normalized Difference Vegetation Index (NDVI data from the Moderate Resolution Imaging Spectroradiometer (MODIS. Model results are compared with radar and other satellite-based images and surface meteorological and PM10 observations. The atmospheric model successfully hindcasted the position of the front in space and time, with about 1 h late arrival in Phoenix. The dust model predicted the rapid uptake of dust and high values of dust concentration in the ensuing storm. South of Phoenix, over the closest source regions (~ 25 km, the model PM10 surface dust concentration reached ~ 2500 μg m−3, but underestimated the values measured by the PM10stations within the city. Model results are also validated by the MODIS aerosol optical depth (AOD, employing deep blue (DB algorithms for aerosol loadings. Model validation included Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO, equipped with the lidar instrument, to disclose the vertical structure of dust aerosols as well as aerosol subtypes. Promising results encourage further

  2. House Prices and Taxes

    DEFF Research Database (Denmark)

    Gjedsted Nielsen, Mads

    This paper is the first to consider a large scale natural experiment to estimate the effect of taxes on house prices. We find that a 1 percentage-point increase in income tax rates lead to a drop in house prices of at most 2.2%. This corresponds to a tax capitalization for the average household of...... only 31%. We use 2007 municipal reform in Denmark in which 256 municipalities changed tax rates, as an exogenous shock to taxes. The exogeneity of the shock to taxes and the size of the data set is an improvement over earlier studies. Our findings significantly downward adjust the degree of tax...... capitalization from earlier studies. Furthermore, we find no effect of property taxes on house prices. We attribute this to the low levels of Danish municipal property tax rates compared to income tax rates....

  3. The book house

    DEFF Research Database (Denmark)

    Jensen, Niels Henrik; Agger, Steen

    1989-01-01

    user-librarian negotiations. These studies led to the identification of a set of strategies for searching and retrieving literature as well as a mutri-kimensional framework for classifying fiction. Both of these have been necessary prerequisites for the design of the BOOK HOUSE, a flexible on-line data......The BOOK HOUSE (and its predecessor, the BOOK AUTOMAT) are computer systems aimed at supporting library users in finding fiction. They are examples of systems using a cognitive work analysis as the basis for design and evaluation - and build on studies of the information retrieval task using actual...... base retrieval system for novice users - both adults and children. The use of icons within a spatial metaphor to facilitate direct manipulation of the displayed objects on the screen forms the basis for the interface in guiding the users' navigation in the BOOK HOUSE. This report, one of three, is...

  4. State Housing Revival

    DEFF Research Database (Denmark)

    Donovan, Elizabeth

    2015-01-01

    Glen Innes. This resulted in a socially, economically and environmentally sustainable neighbourhood proposal which also generated a more culturally flexible home, with environmental sustainable solutions to reduce future financial and environmental pressures. The outcome of the design proposal created......Government funded housing for people in need is a challenge many countries face around the world. This research investigates how to sustainably regenerate post-war suburban state housing in New Zealand, in particular, the suburb of Glen Innes in Auckland. Reviving the community and regenerating the...... buildings is essential for improving the overall quality of the neighbourhoods both socially and physically. Achieving this in a holistic sustainable manner illustrates that there are alternatives to demolition and new builds, as the answer to the current housing shortage problems. New Zealand is confronted...

  5. Dust ablation in Pluto's atmosphere

    Science.gov (United States)

    Horanyi, Mihaly; Poppe, Andrew; Sternovsky, Zoltan

    2016-04-01

    Based on measurements by dust detectors onboard the Pioneer 10/11 and New Horizons spacecraft the total production rate of dust particles born in the Edgeworth Kuiper Belt (EKB) has been be estimated to be on the order of 5 ṡ 103 kg/s in the approximate size range of 1 - 10 μm. Dust particles are produced by collisions between EKB objects and their bombardment by both interplanetary and interstellar dust particles. Dust particles of EKB origin, in general, migrate towards the Sun due to Poynting-Robertson drag but their distributions are further sculpted by mean-motion resonances as they first approach the orbit of Neptune and later the other planets, as well as mutual collisions. Subsequently, Jupiter will eject the vast majority of them before they reach the inner solar system. The expected mass influx into Pluto atmosphere is on the order of 200 kg/day, and the arrival speed of the incoming particles is on the order of 3 - 4 km/s. We have followed the ablation history as function of speed and size of dust particles in Pluto's atmosphere, and found that volatile rich particles can fully sublimate due to drag heating and deposit their mass in narrow layers. This deposition might promote the formation of the haze layers observed by the New Horizons spacecraft. This talk will explore the constraints on the composition of the dust particles by comparing the altitude of the deposition layers to the observed haze layers.

  6. Lonqueville House: Tasting Menu

    OpenAIRE

    Lonqueville House Hotel

    2013-01-01

    Lonqueville House is a 4 star Georgian House hotel located in Mallow, Co. Cork. Kitchen Philosophy; "At Longueville Guests may savour the freshest produce from the estate and surrounding areas, in original culinary creations cooked by chef and patron William O'Callaghan and his team in this renowned kitchen. William trained under Master Chef Raymond Blanc at Le Manoir aux Quat’Saisons, a two-Michelin-star restaurant where the menu is described as having ‘a twist of imaginative genius...

  7. Mass transfer of PBDEs from plastic TV casing to indoor dust via three migration pathways--A test chamber investigation.

    Science.gov (United States)

    Rauert, C; Harrad, S

    2015-12-01

    Polybrominated diphenyl ethers (PBDEs) are widely detected in humans with substantial exposure thought to occur in indoor environments and particularly via contact with indoor dust. Despite this, knowledge of how PBDEs migrate to indoor dust from products within which they are incorporated is scarce. This study utilises an in-house designed and built test chamber to investigate the relative significance of different mechanisms via which PBDEs transfer from source materials to dust, using a plastic TV casing treated with the Deca-BDE formulation as a model source. Experiments at both room temperature and 60°C revealed no detectable transfer of PBDEs from the TV casing to dust via volatilisation and subsequent partitioning. In contrast, substantial transfer of PBDEs to dust was detected when the TV casing was abraded using a magnetic stirrer bar. Rapid and substantial PBDE transfer to dust was also observed in experiments in which dust was placed in direct contact with the source. Based on these experiments, we suggest that for higher molecular weight PBDEs like BDE-209; direct dust:source contact is the principal pathway via which source-to-dust transfer occurs. PMID:26247685

  8. Nonlinear theory of dust lattice mode coupling in dust crystals

    CERN Document Server

    Kourakis, I; Kourakis, Ioannis; Shukla, Padma Kant

    2004-01-01

    Quasi-crystals formed by charged mesoscopic dust grains (dust lattices), observed since hardly a decade ago, are an exciting paradigm of a nonlinear chain. In laboratory discharge experiments, these quasi-lattices are formed spontaneously in the sheath region near a negative electrode, usually at a levitated horizontal equilibrium configuration where gravity is balanced by an electric field. It is long known (and experimentally confirmed) that dust-lattices support linear oscillations, in the longitudinal (acoustic mode) as well as in the transverse, in plane (acoustic-) or off-plane (optic-like mode) directions. Either due to the (typically Yukawa type) electrostatic inter-grain interaction forces or to the (intrinsically nonlinear) sheath environment, nonlinearity is expected to play an important role in the dynamics of these lattices. Furthermore, the coupling between the different modes may induce coupled nonlinear modes. Despite this evidence, the elucidation of the nonlinear mechanisms governing dust cr...

  9. Dust Storm Events in Iceland: Physical Properties of Icelandic Dust

    Czech Academy of Sciences Publication Activity Database

    Dagsson-Waldhauserova, P.; Arnalds, O.; Olafsson, H.; Škrabalová, L.; Sigurdardottir, G. M.; Braniš, M.; Hladil, Jindřich; Skála, Roman; Navrátil, Tomáš; Chadimová, Leona; von Lowis of Menar, S.; Thorsteinsson, T.

    s. l : s. n, 2013. [International Workshop on Sand /Duststorms and Associated Dustfall /7./. 02.12.2013-04.12.2013, Rome] Institutional support: RVO:67985831 Keywords : dust * geology * geochemistry Subject RIV: DB - Geology ; Mineralogy

  10. Triton's streaks as windblown dust

    Science.gov (United States)

    Sagan, Carl; Chyba, Christopher

    1990-01-01

    Explanations for the surface streaks observed by Voyager 2 on Triton's southern hemisphere are discussed. It is shown that, despite Triton's tenuous atmosphere, low-cohesion dust trains with diameters of about 5 micron or less may be carried into suspension by aeolian surface shear stress, given expected geostrophic wind speeds of about 10 m/s. For geyser-like erupting dust plumes, it is shown that dust-settling time scales and expected wind velocities can produce streaks with length scales in good agreement with those of the streaks. Thus, both geyserlike eruptions or direct lifting by surface winds appear to be viable mechanisms for the origin of the streaks.

  11. Customer Satisfaction Theory Applied in the Housing Industry:An Empirical Study of Low-Priced Housing in Beijing

    Institute of Scientific and Technical Information of China (English)

    YANG Song; ZHU Yan

    2006-01-01

    A household satisfaction index (HSI) model based on the American customer satisfaction index (ACSI) model was fit to the housing industry in China and used with the software LISREL to measure the HSI in Beijing. Specifically, the empirical study analyzes the HSI of low-priced housing in Beijing. The results show that the HSI model is valid and the customer satisfaction theory can effectively analyze the housing industry. The results can help illustrate the factors which most affect customer satisfaction, and can be used to not only enhance the quality of homes and promote the housing market, but also to improve the standard of living for lower income people and provide suggestions to policy makers.

  12. Defensive Localism in White and Black: A Comparative History of European-American and African-American Youth Gangs.

    Science.gov (United States)

    Adamson, Christopher

    2000-01-01

    Compares European American and African American youth gangs in four historical periods (seaboard, immigrant, racially changing, and hypersegregated cities), showing that differences can be traced to race-specific effects of labor, housing, and consumer markets, government policies, local politics, and organized crime on their communities.…

  13. The Sky in Dust -- Methods and Prospects of Dust Astronomy

    CERN Document Server

    Landgraf, M; Srama, R; Helfert, S; Kempf, S; Morgas-Klostermeyer, G; Rachev, M; Srowig, A; Auer, S; Hor`anyi, M; Sternovsky, Z; Harris, D

    2006-01-01

    Information about the make-up of the galaxy arrives in the Solar system in many forms: photons of different energies, classically collected by ground- and space-based telescopes, neutral and charged atomic particles, and solid macroscopic particles: cosmic dust particles. Dust particles, like photons, carry information from remote sites in space and time. This information can be analysed in order to understand the processes and mechanisms that are involved in the formation and evolution of solid matter in the galaxy. This approach is called ``Dust Astronomy'' which is carried out by means of a dust telescope on a dust observatory in space. The analysis of cosmic grains collected in the high atmosphere of the Earth has shown that each dust grain is a small world with various sub-grains featuring different galactic origin and evolution, which is identified on the basis of elementary and isotopic analysis. Independent information about the origin and evolution of the grains coming from the kinematic properties o...

  14. PERSPECTIVE: Dust, fertilization and sources

    Science.gov (United States)

    Remer, Lorraine A.

    2006-11-01

    Aerosols, tiny suspended particles in the atmosphere, play an important role in modifying the Earth's energy balance and are essential for the formation of cloud droplets. Suspended dust particles lifted from the world's arid regions by strong winds contain essential minerals that can be transported great distances and deposited into the ocean or on other continents where productivity is limited by lack of usable minerals [1]. Dust can transport pathogens as well as minerals great distance, contributing to the spread of human and agricultural diseases, and a portion of dust can be attributed to human activity suggesting that dust radiative effects should be included in estimates of anthropogenic climate forcing. The greenish and brownish tints in figure 1 show the wide extent of monthly mean mineral dust transport, as viewed by the MODerate resolution Imaging Spectroradiometer (MODIS) satellite sensor. The monthly mean global aerosol system for February 2006 from the MODIS aboard the Terra satellite Figure 1. The monthly mean global aerosol system for February 2006 from the MODIS aboard the Terra satellite. The brighter the color, the greater the aerosol loading. Red and reddish tints indicate aerosol dominated by small particles created primarily from combustion processes. Green and brownish tints indicate larger particles created from wind-driven processes, usually transported desert dust. Note the bright green band at the southern edge of the Saharan desert, the reddish band it must cross if transported to the southwest and the long brownish transport path as it crosses the Atlantic to South America. Image courtesy of the NASA Earth Observatory (http://earthobservatory.nasa.gov). Even though qualitatively we recognize the extent and importance of dust transport and the role that it plays in fertilizing nutrient-limited regions, there is much that is still unknown. We are just now beginning to quantify the amount of dust that exits one continental region and the

  15. Twisted Dust Acoustic Waves in Dusty Plasmas

    CERN Document Server

    Shukla, P K

    2012-01-01

    We examine linear dust acoustic waves (DAWs) in a dusty plasma with strongly correlated dust grains, and discuss possibility of a twisted DA vortex beam carrying orbital angular momentum (OAM). For our purposes, we use the Boltzmann distributed electron and ion density perturbations, the dust continuity and generalized viscoelastic dust momentum equations, and Poisson's equation to obtain a dispersion relation for the modified DAWs. The effects of the polarization force, strong dust couplings, and dust charge fluctuations on the DAW spectrum are examined. Furthermore, we demonstrate that the DAW can propagate as a twisted vortex beam carrying OAM. A twisted DA vortex structure can trap and transport dust particles in dusty plasmas.

  16. The Children's House

    Science.gov (United States)

    Peller, Lili E.

    2013-01-01

    Lili Peller's "The Children's House" essay begins where Maria Montessori left off in her description of space articulations. Peller does not name Montessori specifically as she always had a desire to become independent in her own right as a neo-Freudian child analyst. But the Haus Der Kinder founded in summer of 1922 suggests a total…

  17. The Nordic Housing Enabler

    DEFF Research Database (Denmark)

    Helle, T.; Nygren, C.; Slaug, B.;

    2014-01-01

    This study addresses development of a content-valid cross-Nordic version of the Housing Enabler and investigation of its inter-rater reliability when used in occupational therapy rating situations, involving occupational therapists, clients, and their home environments. The instrument was...

  18. How Housing Benefit Residents?

    Institute of Scientific and Technical Information of China (English)

    Lynn Zhang

    2008-01-01

    @@ At 2008's NPC and CPPCC sessions,the nation's housing program has kbecome one of the top concerns;some deputies from academic institutions and the real estate industry have submitted their own proposals on how to deal with the issue.

  19. Dutch House Martins

    NARCIS (Netherlands)

    Piersma, T.; van der Velde, M.

    2012-01-01

    In a southern Spanish population of the colonial-breeding Afrotropical migrant House Martins Delichon urbicum, a high overall prevalence of (molecularly assayed) haemosporidian infections (in the non-parasitological literature usually denoted with the inclusive term 'malaria') was associated with ne

  20. The Nordic Housing Enabler

    DEFF Research Database (Denmark)

    Helle, Tina; Slaug, Bjørn; Brandt, Åse;

    2010-01-01

    research in the Nordic context. The varying kappa results highlights the need for further study in order to understand the influence of prevalence more profoundly, which should be kept in mind when interpreting the results. Keywords: Accessibility, physical environment, housing adaptation, occupational...

  1. Hood River Passive House

    Energy Technology Data Exchange (ETDEWEB)

    Hales, David [BA-PIRC, Spokane, WA (United States)

    2014-01-01

    The Hood River Passive Project was developed by Root Design Build of Hood River Oregon using the Passive House Planning Package (PHPP) to meet all of the requirements for certification under the European Passive House standards. The Passive House design approach has been gaining momentum among residential designers for custom homes and BEopt modeling indicates that these designs may actually exceed the goal of the U.S. Department of Energy's (DOE) Building America program to "reduce home energy use by 30%-50% (compared to 2009 energy codes for new homes). This report documents the short term test results of the Shift House and compares the results of PHPP and BEopt modeling of the project. The design includes high R-Value assemblies, extremely tight construction, high performance doors and windows, solar thermal DHW, heat recovery ventilation, moveable external shutters and a high performance ductless mini-split heat pump. Cost analysis indicates that many of the measures implemented in this project did not meet the BA standard for cost neutrality. The ductless mini-split heat pump, lighting and advanced air leakage control were the most cost effective measures. The future challenge will be to value engineer the performance levels indicated here in modeling using production based practices at a significantly lower cost.

  2. Housing price forecastability

    DEFF Research Database (Denmark)

    Bork, Lasse; Møller, Stig Vinther

    2012-01-01

    We examine US housing price forecastability using a common factor approach based on a large panel of 122 economic time series. We …nd that a simple three-factor model generates an explanatory power of about 50% in one-quarter ahead in-sample forecasting regressions. The predictive power of the mo...

  3. Vietnam Affordable Housing

    OpenAIRE

    World Bank Group

    2015-01-01

    Affordable housing will be instrumental to helping Vietnam achieve its goals for increasing productivity and inclusive urban growth. Since Doi Moi, the country has experienced impressive economic growth, averaged at 7.4 percent per annum from 1990 to 2008, lowering to an average of 6 percent per annum from 2007 to 2013. Strong economic growth has supported a substantial reduction in povert...

  4. Haunted by Houses

    Science.gov (United States)

    McNeece, Molly

    2009-01-01

    Two fourth-grade teachers presented the idea of using the author's art class to inspire the students to write creatively. The theme of scary stories needed an art project to match. The author immediately had a favorite lesson in mind. By putting a small twist on one of her standard "Frank Lloyd Wright House" projects, scary plans began to take…

  5. Hood River Passive House

    Energy Technology Data Exchange (ETDEWEB)

    Hales, D.

    2014-01-01

    The Hood River Passive Project was developed by Root Design Build of Hood River Oregon using the Passive House Planning Package (PHPP) to meet all of the requirements for certification under the European Passive House standards. The Passive House design approach has been gaining momentum among residential designers for custom homes and BEopt modeling indicates that these designs may actually exceed the goal of the U.S. Department of Energy's (DOE) Building America program to reduce home energy use by 30%-50% (compared to 2009 energy codes for new homes). This report documents the short term test results of the Shift House and compares the results of PHPP and BEopt modeling of the project. The design includes high R-Value assemblies, extremely tight construction, high performance doors and windows, solar thermal DHW, heat recovery ventilation, moveable external shutters and a high performance ductless mini-split heat pump. Cost analysis indicates that many of the measures implemented in this project did not meet the BA standard for cost neutrality. The ductless mini-split heat pump, lighting and advanced air leakage control were the most cost effective measures. The future challenge will be to value engineer the performance levels indicated here in modeling using production based practices at a significantly lower cost.

  6. Control on Housing Segregation:Housing Modes and Public Policies

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>1. Housing segregation:advocating or controlling?The phenomenon of housing segregation has become more and more obvious in Chinese cities in recent years; however, there is no agreement on whether it should

  7. Assisted Housing - Public Housing Buildings - National Geospatial Data Asset (NGDA)

    Data.gov (United States)

    Department of Housing and Urban Development — The approximate physical location of each individual Public Housing Building. If the building has more than one entrance or street address, the address of the...

  8. Metals and dust in high redshift AGNs

    CERN Document Server

    Maiolino, R; Marconi, A; Schneider, R; Bianchi, S; Pedani, M; Pipino, A; Matteucci, F; Cox, P; Caselli, P

    2006-01-01

    We summarize some recent results on the metallicity and dust properties of Active Galactic Nuclei (AGN) at high redshift (110). The properties of dust in high-z QSOs are discussed within the context of the dust production mechanisms in the early universe. The dust extinction curve is observed to evolve beyond z>4, and by z~6 it is well described by the properties expected for dust produced by SNe, suggesting that the latter is the main mechanism of dust production in the early universe. We also show that the huge dust masses observed in distant QSOs can be accounted for by SN dust within the observational constraints currently available. Finally, we show that QSO winds, which have been proposed as an alternative mechanism of dust production, may also contribute significantly to the total dust budget at high redshift.

  9. 24 CFR 1715.27 - Fair housing.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Fair housing. 1715.27 Section 1715.27 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND...

  10. Loess and Eolian Dust Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records of past environment derived from Loess and Eolian dust (silt-sized material deposited on the Earth surface by the surface winds. Parameter keywords describe...

  11. Surface System Dust Mitigation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed effort will perform a detailed examination of dust mitigation and tolerance strategies for connections and mechanisms to be employed on the lunar...

  12. Infrared astronony and galactic dust

    International Nuclear Information System (INIS)

    A review of infrared sources of cosmic radiation - interstellar dust clouds, cocoon stars, novae, and gas supergiants - is presented. The possibilities of exact estimation of the star and galaxy brightness are considered. The difficulties of experiments and the reasons for choosing the infrared range for observations (teh maximum radiation of cold dust particles and the high transparency of the dust clouds) are noted. A Galaxy centre strongly radiating in the infrared range and situated in the Sagittarius constellation is considered as an example, and its schematic picture is given. A rough estimate of the absorption by stellar structures, dust and gas clouds is given. The diagram of the Main sequence of infrared sources and the dependence of their luminosity on the effective temperature are presented. The energy distribution in the spectrum of a complex object at different temperatures and wave lengths is considered. The frequency dependence of the radiation flux for the objects of the Orion constellation is given

  13. Housing Subsidies: Effects on Housing Decisions, Efficiency, and Equity

    OpenAIRE

    Rosen, Harvey S.

    1983-01-01

    This paper surveys the effects of two of the most important federal policies toward housing: the "implicit subsidy" for owner-occupied housing in the income tax code, and the provision of housing for low income families at rents below cost. Emphasis is placed on the methodological problems that arise in attempts to assess the efficiency and distributive implications of these programs.Section 1 critically discusses the rationalization for a government housing policy. Section 2 investigates the...

  14. Housing and Housing Finance: The View from Australia and Beyond

    OpenAIRE

    Luci Ellis

    2006-01-01

    This paper draws together themes from work at the RBA, other national central banks, the BIS and elsewhere on recent developments in housing and housing finance. The general conclusion is that financial and macroeconomic developments have increased the demand for the stock of housing. Because the stock of housing is inherently slow to adjust, this has increased its relative price. Although this is a global trend, individual country institutions have affected outcomes, sometimes in ways that a...

  15. Sustainable Housing Renewal

    Directory of Open Access Journals (Sweden)

    M. Sitar

    2008-01-01

    Full Text Available Following the already proved models the sustainable planning culture is endangering several methods directed towards the needs of tenants in the existing post-war housing stock. The case-study of our project is the renewal of the multi stored building in the housing estate Metalna, Maribor/Tezno (1949. It is based on the sustainable renovation principle for the quality of sustainable housing in functional, technological and environmental point of view. According to it, the idea of the project was to improve the functionality of the building as well as of individual housing units. One of the main goals was to introduce the variety of space and typology of individual housing units. Beside, there was an intention to rebuild and redesign the green area, especially the problems of parking and playground for children. On the other hand, the project is introducing the low-energy renovation principle including new technologies, structural elements and materials. Two scenarios of technological renewal were suggested. The first one was a classical one using additional thermal insulation of the building envelope and fitting of new structural elements such as windows, doors, balconies, windbreaks etc. (Renewal 1. The second scenario, however, included the sunspace construction used as a new passive solar structural element, modifying the envelope (Renewal 2. The energy efficiency of the suggested scenarios were calculated according to the procedures given in EN 832 standard considering the attached sunspace as integral part of the building in first case and as a passive solar object adjacent to the thermal envelope of the building in the second case. The results show that the last case yields the most energy efficient renewal of the existing residential building.

  16. Personal dust exposures at a food processing facility.

    Science.gov (United States)

    Lacey, Steven E; Conroy, Lorraine M; Forst, Linda S; Franke, John E; Wadden, Richard A; Hedeker, Donald R

    2006-01-01

    A field study was performed to quantify personal dust exposures at a food processing facility. A review of the literature shows very little exposure information in the food processing industry. The processing area consisted of a series of four rooms, connected by a closed-loop ventilation system, housed within a larger warehouse-type facility. Workers were exposed to various fruit and vegetable dusts during the grinding, sieving, mixing and packaging of freeze-dried or air-dried products. Eight two-hour periods were monitored over two days. Personal total suspended particulate samples were collected on 37 mm PVC filters with 5 microm pore size according to National Institute for Occupational Safety and Health (NIOSH) Method 0500. The filters were analyzed gravimetrically. The two-hour task sampling personal dust exposures ranged from 0.33-103 mg/m3. For each worker, an eight-hour time weighted average (TWA) concentration was calculated, and these ranged from 3.08-59.8 mg/m3. Although there are no directly appropriate occupational exposure limits that may be used for comparison, we selected the Threshold Limit Value (TLV) for particulates not otherwise classified (PNOC) of 10 mg/m3 for inhalable particles. Neglecting the respiratory protection used, five out of eight of the worker time-weighted averages exceeded the TLV. It should be noted that the TLV is based on the inhalable fraction and in this study total suspended particulate was measured; additionally, the TLV is applicable for dusts that are insoluble or poorly soluble, and have low toxicity, which may have limited protective ability in this case due to the irritant nature of certain dusts (e.g., jalapeno peppers, aloe vera). Sieving resulted in significantly higher exposure than grinding and blending. Measuring area concentrations alone in this environment is not a sufficient method of estimating personal exposures due to work practices for some operations. PMID:16893837

  17. Dust in protoplanetary disks: observations*

    OpenAIRE

    Waters L.B.F.M.

    2015-01-01

    Solid particles, usually referred to as dust, are a crucial component of interstellar matter and of planet forming disks surrounding young stars. Despite the relatively small mass fraction of ≈1% (in the solar neighborhood of our galaxy; this number may differ substantially in other galaxies) that interstellar grains represent of the total mass budget of interstellar matter, dust grains play an important role in the physics and chemistry of interstellar matter. This is because of the opacity ...

  18. Saharan Dust Pollution: Implications for the Sahel?

    OpenAIRE

    De Longueville, Florence; Henry, Sabine; Ozer, Pierre

    2009-01-01

    The main source of atmospheric mineral dust is the Sahara desert, which produces about half of the yearly global mineral dust.1 About 12% of the Saharan dust moves northwards to Europe, 28% westwards to the Americas, and 60% southwards to the Gulf of Guinea. Saharan dust storms can lead to particulate matter (PM) levels that exceed internationally recommended levels. Recently, special attention has been paid to the mineral PM air pollution of dust storms, which may be a serious health threat....

  19. Suspended dust in Norwegian cities

    International Nuclear Information System (INIS)

    According to calculations, at least 80 000 people in Oslo and 8 000 in Trondheim were annoyed by too much suspended dust in 2000. The dust concentration is greatest in the spring, presumably because dust is swirling up from melting snow and ice on the streets. Car traffic is the main source of the dust, except for some of the most highly exposed regions where wood-firing from old stoves contributes up to 70 percent of the dust. National targets for air quality include suspended dust, nitrogen dioxide, sulphur dioxide and benzene. Calculations show that nitrogen dioxide emissions exceeding the limit affected 4 000 people in Oslo and 1 000 people in Trondheim. The sulphur dioxide emissions in the major cities did non exceed the national quality limit; they did exceed the limit in some of the smaller industrial centres. In Trondheim, measurements show that the national limit for benzene was exceeded. Most of the emission of nitrogen dioxide comes from the road traffic. Local air pollution at times causes considerable health- and well-being problems in the larger cities and industrial centres, where a great part of the population may be at risk of early death, infection of the respiratory passage, heart- and lung diseases and cancer

  20. Comparison between light scattering and gravimetric samplers for PM10 mass concentration in poultry and pig houses

    Science.gov (United States)

    Cambra-López, María; Winkel, Albert; Mosquera, Julio; Ogink, Nico W. M.; Aarnink, André J. A.

    2015-06-01

    The objective of this study was to compare co-located real-time light scattering devices and equivalent gravimetric samplers in poultry and pig houses for PM10 mass concentration, and to develop animal-specific calibration factors for light scattering samplers. These results will contribute to evaluate the comparability of different sampling instruments for PM10 concentrations. Paired DustTrak light scattering device (DustTrak aerosol monitor, TSI, U.S.) and PM10 gravimetric cyclone sampler were used for measuring PM10 mass concentrations during 24 h periods (from noon to noon) inside animal houses. Sampling was conducted in 32 animal houses in the Netherlands, including broilers, broiler breeders, layers in floor and in aviary system, turkeys, piglets, growing-finishing pigs in traditional and low emission housing with dry and liquid feed, and sows in individual and group housing. A total of 119 pairs of 24 h measurements (55 for poultry and 64 for pigs) were recorded and analyzed using linear regression analysis. Deviations between samplers were calculated and discussed. In poultry, cyclone sampler and DustTrak data fitted well to a linear regression, with a regression coefficient equal to 0.41, an intercept of 0.16 mg m-3 and a correlation coefficient of 0.91 (excluding turkeys). Results in turkeys showed a regression coefficient equal to 1.1 (P = 0.49), an intercept of 0.06 mg m-3 (P cyclone pre-separators. Absolute, relative, and random deviations increased with concentration. DustTrak light scattering devices should be self-calibrated to investigate PM10 mass concentrations accurately in animal houses. We recommend linear regression equations as animal-specific calibration factors for DustTraks instead of manufacturer calibration factors, especially in heavily dusty environments such as animal houses.

  1. Multifamily Housing Physical Inspection Scores

    Data.gov (United States)

    Department of Housing and Urban Development — HUD's Real Estate Assessment Center conducts physical property inspections of properties that are owned, insured or subsidized by HUD, including public housing and...

  2. FEMA Housing Assistance Renters - API

    Data.gov (United States)

    Department of Homeland Security — This dataset lists aggregated, non-PII dataset of FEMA Housing Assistance Program for House Renters The data was generated by FEMA's ECIM (Enterprise Coordination...

  3. Public Housing Agency (PHA) Inventory

    Data.gov (United States)

    Department of Housing and Urban Development — The dataset contains current data on low rent and Section 8 units in PHA's administered by HUD. The Section 8 Rental Voucher Program increases affordable housing...

  4. HUD Approved Housing Counseling Agencies

    Data.gov (United States)

    Department of Housing and Urban Development — HUD sponsors housing counseling agencies throughout the country that can provide advice on buying a home, renting, defaults, foreclosures, and credit issues. This...

  5. FEMA Housing Assistance Owners - API

    Data.gov (United States)

    Department of Homeland Security — This dataset lists aggregated, non-PII dataset of FEMA Housing Assistance Program for House Owners The data was generated by FEMA's ECIM (Enterprise Coordination...

  6. House Committee on Veterans' Affairs

    Science.gov (United States)

    ... form Search Sign up to receive email updates House Committee on Veterans' Affairs About Chair Membership Hearing ... Investigations (O&I) Meet the Committee The 114th House Committee on Veterans’ Affairs Meet the Chairman The ...

  7. Public Housing Physical Inspection Scores

    Data.gov (United States)

    Department of Housing and Urban Development — HUD's Real Estate Assessment Center conducts physical property inspections of properties that are owned, insured or subsidized by HUD, including public housing and...

  8. 78 FR 70956 - 30-Day Notice of Proposed Information Collection: Assessment of Native American, Alaska Native...

    Science.gov (United States)

    2013-11-27

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Assessment of Native American... Title of Information Collection: Assessment of Native American, Alaska Native and Native Hawaiian... American and Alaskan Native populations, most notably through the Indian Housing Block Grant. The level...

  9. 78 FR 75365 - 30-Day Notice of Proposed Information Collection: Assessment of Native American, Alaska Native...

    Science.gov (United States)

    2013-12-11

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Assessment of Native American... Collection: Assessment of Native American, Alaska Native and Native Hawaiian Housing Needs. OMB Approval... the United States. HUD provides funding though several programs to Native American and Alaskan...

  10. The Chinese Housing Provident Fund

    OpenAIRE

    Richard J. Buttimer Jr; Anthony Yanxiang Gu; Tyler T. Yang

    2004-01-01

    The Chinese government has embarked upon an effort to reduce the number of tenants living in publicly owned housing. This is a significant challenge for any government, but may be especially so for a country where private homeownership is a new option. Out of concern that many of its citizens could not afford to purchase their housing units, the Chinese government created the Housing Provident Fund. This program, which is similar to housing fund programs in other countries such as Thailand an...

  11. Consumption, house prices and expectations

    OpenAIRE

    Orazio Attanasio; Laura Blow; Robert Hamilton; Andrew Leicester

    2005-01-01

    Over much of the past 25 years, the cycles of house price and consumption growth have been closely synchronised. Three main hypotheses for this co-movement have been proposed in the literature. First, that an increase in house prices raises households' wealth, particularly for those in a position to trade down the housing ladder, which increases their desired level of expenditure. Second, that house price growth increases the collateral available to homeowners, reducing credit constraints and...

  12. Housing Wealth and Retirement Timing

    OpenAIRE

    Martin Farnham; Purvi Sevak

    2007-01-01

    We use data from the Health and Retirement Study (HRS) and the Office of Housing Enterprise Oversight to measure the effect of changes in housing wealth on retirement timing. Using cross-MSA variation in house-price movements to identify wealth effects on retirement timing, we find evidence that such wealth effects are present. According to some specifications the rate of transition into retirement increases in the presence of positive housing wealth shocks. In addition, we use data on expect...

  13. Sexual Networks and Housing Stability

    OpenAIRE

    Davey-Rothwell, Melissa A.; Latimore, Amanda; Hulbert, Alicia; Latkin, Carl A.

    2011-01-01

    Unstable housing is related to a range of health problems including substance abuse, poor mental health, and HIV. Little is known about how sexual partners’ attributes influence access to resources such as housing. The purpose of the present study was to examine the relationship between sexual network characteristics and improvements in housing situation among a sample of drug users using a longitudinal design. Size of one’s sex network was not associated with housing change. However, having ...

  14. Understanding house-price dynamics

    OpenAIRE

    Makoto Nakajima

    2011-01-01

    For most homeowners, housing is the single most important component of their nonpension wealth. Therefore, a change in house prices greatly affects the total wealth of many households. Furthermore, movements in house prices can affect people’s lives indirectly. For example, the surge in the number of mortgage defaults and foreclosures during the recent recession was triggered in part by a drop in house prices, and this surge damaged the health of the financial institutions that either directl...

  15. Variability of particle size-specific fractions of personal coal mine dust exposures.

    Science.gov (United States)

    Seixas, N S; Hewett, P; Robins, T G; Haney, R

    1995-03-01

    This study estimated the ratio of the tracheo-bronchial dust fraction to the fraction collected by a respirable dust sampler for a variety of job classifications found in conventional, continuous, and longwall coal mining sections. The ratios could then be applied in epidemiologic studies to existing respirable dust measurements to estimate thoracic mass concentrations for evaluation of the relative importance of the respirable and thoracic dust fractions to obstructive lung disease. Data collected include particle size distributions from four U.S. underground coal mines using eight-stage personal cascade impactors. A total of 180 samples were examined by mine, occupation and occupations grouped by proximity to the mine face, and by mining technology. Several fractions--that collected by the 10-mm nylon cyclone, the American Conference of Governmental Industrial Hygienists respirable and thoracic particulate mass fractions, and the estimated alveolar and tracheo-bronchial deposition fractions--were estimated. These were not significantly different when grouped by occupation, by proximity of work to the mine face, or by the type of mining technology in use. Distributions from one mine varied from the others, perhaps because it used diesel equipment in the haulage ways, which contributed to the fine aerosol fractions. Results suggest that although the tracheo-bronchial dust fraction may contribute to the development of obstructive lung disease, occupation-specific tracheo-bronchial dust fractions are not likely to produce stronger exposure-response estimates than the historically collected respirable dust concentrations. PMID:7717269

  16. Estimation of high altitude Martian dust parameters

    Science.gov (United States)

    Pabari, Jayesh; Bhalodi, Pinali

    2016-07-01

    Dust devils are known to occur near the Martian surface mostly during the mid of Southern hemisphere summer and they play vital role in deciding background dust opacity in the atmosphere. The second source of high altitude Martian dust could be due to the secondary ejecta caused by impacts on Martian Moons, Phobos and Deimos. Also, the surfaces of the Moons are charged positively due to ultraviolet rays from the Sun and negatively due to space plasma currents. Such surface charging may cause fine grains to be levitated, which can easily escape the Moons. It is expected that the escaping dust form dust rings within the orbits of the Moons and therefore also around the Mars. One more possible source of high altitude Martian dust is interplanetary in nature. Due to continuous supply of the dust from various sources and also due to a kind of feedback mechanism existing between the ring or tori and the sources, the dust rings or tori can sustain over a period of time. Recently, very high altitude dust at about 1000 km has been found by MAVEN mission and it is expected that the dust may be concentrated at about 150 to 500 km. However, it is mystery how dust has reached to such high altitudes. Estimation of dust parameters before-hand is necessary to design an instrument for the detection of high altitude Martian dust from a future orbiter. In this work, we have studied the dust supply rate responsible primarily for the formation of dust ring or tori, the life time of dust particles around the Mars, the dust number density as well as the effect of solar radiation pressure and Martian oblateness on dust dynamics. The results presented in this paper may be useful to space scientists for understanding the scenario and designing an orbiter based instrument to measure the dust surrounding the Mars for solving the mystery. The further work is underway.

  17. Housing wealth accumulation: The role of public housing

    OpenAIRE

    GOFFETTE-NAGOT, Florence; Sidibé, Modibo

    2014-01-01

    The public housing sector provides housing units at below-market rents, potentially allowing its tenants to save for a downpayment more quickly than they would have otherwise. In this paper, we analyze the effect of a spell in public housing on age at first-time homeownership using the French Housing Survey. We use a pseudo-panel approach that takes into account the specificities of the local housing market, to derive individual tenure transitions from multiple cross-sections data. Using an I...

  18. Dust Particle Size Distributions during Spring in Yinchuan, China

    OpenAIRE

    Jiangfeng Shao; Jiandong Mao

    2016-01-01

    Dust particle size distributions in Yinchuan, China, were measured during March and April 2014, using APS-3321 sampler. The distributions were measured under different dust conditions (background, floating dust, blowing dust, and dust storm) and statistical analyses were performed. The results showed that, under different dust conditions, the instantaneous number concentrations of dust particles differed widely. For example, during blowing sand and dust storm conditions, instantaneous dust pa...

  19. Literacy Mediation in Neighbourhood Houses

    Science.gov (United States)

    Thompson, Sally

    2015-01-01

    Interactions between staff in Neighbourhood Houses, and the socially and educationally disadvantaged community members who visit Neighbourhood Houses, have been viewed through many lenses, including community development, social support, caring and compassion. This paper looks at Neighbourhood Houses as sites of pedagogical practice. More…

  20. Climate change and climate systems influence and control the atmospheric dispersion of desert dust: implications for human health

    Science.gov (United States)

    Griffin, Dale W.

    2010-01-01

    The global dispersion of desert dust through Earth’s atmosphere is greatly influenced by temperature. Temporal analyses of ice core data have demonstrated that enhanced dust dispersion occurs during glacial events. This is due to an increase in ice cover, which results in an increase in drier terrestrial cover. A shorter temporal analysis of dust dispersion data over the last 40 years has demonstrated an increase in dust transport. Climate systems or events such as the North Atlantic Oscillation, the Indian Ocean subtropical High, Pacific Decadal Oscillation, and El Nino-Sothern Oscillation are known to influence global short-term dust dispersion occurrence and transport routes. Anthropogenic influences on dust transport include deforestation, harmful use of topsoil for agriculture as observed during the American Dust Bowl period, and the creation of dry seas (Aral Sea) and lakes (Lake Owens in California and Lake Chad in North Africa) through the diversion of source waters (for irrigation and drinking water supplies). Constituents of desert dust both from source regions (pathogenic microorganisms, organic and inorganic toxins) and those scavenged through atmospheric transport (i.e., industrial and agricultural emissions) are known to directly impact human and ecosystem health. This presentation will present a review of global scale dust storms and how these events can be both a detriment and benefit to various organisms in downwind environments.

  1. American Dream in Early American Literatuer

    Institute of Scientific and Technical Information of China (English)

    屈彩娥; 李小玺

    2008-01-01

    American dream has often been closely rehted to American literature.Many say that the American literary history can be seen as the history of American dreams.In most periods in history,writers,whose dreams have been infused in a variety of characters create the American literature.While in Early American literature,American dream had been presented in a dif-ferent way.

  2. Effect of Thermionic Emission on Dust-Acoustic Solitons in a Dust-Electron Plasma

    Institute of Scientific and Technical Information of China (English)

    REN Li-Wen; WANG Zheng-Xiong; LIU Yue; WANG Xiao-Gang

    2007-01-01

    The effects of thermionic emission on dust-acoustic solitons with a very small but finite amplitude in a dustelectron plasma are studied using the reductive perturbation technique. The self-consistent variation of dust charge is taken into account. It is shown that the thermionic emission could significantly increase the dust positive charge. The dependences of the phase velocity, amplitude, and width of such solitons on the dust temperature and the dust work function of dust material are plotted and discussed.

  3. House OK's Russian aid

    International Nuclear Information System (INIS)

    This article discusses the 2.5 Billion dollar aid package to Russia which House Appropriations Foreign Operations Subcommittee Chairman David Obey successfully defended on the House floor last June. Arizona Republican Jon Kyl offered an admendment that would cut 700 million from the package and was defeated with a 118 to 140 vote. The bill is currently in the hands of the Senate. The controversy over the bill and details concerning the aid package are discussed. The aid deal includes 250 million dollars for nuclear reactor safety and energy as well as environmental technical assistance, 655 million dollars to aid private sector development, and 704 million dollars for additional technical and economic assistance

  4. LIGHT*HOUSE

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Nielsen, Benjamin; Madsen, Jesper V;

    Med udgangspunkt i det konkrete byggeprojekt Light*house, der skal opføres på Århus havn, er der i projektet foretaget en række analyser til bestemmelse af de geotekniske egenskaber for den fede tertiære ler fra søvindmergel-formationen, som findes på lokaliteten til stor dybde. Søvindmerglens...

  5. Housing characteristics 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This report, Housing Characteristics 1993, presents statistics about the energy-related characteristics of US households. These data were collected in the 1993 Residential Energy Consumption Survey (RECS) -- the ninth in a series of nationwide energy consumption surveys conducted since 1978 by the Energy Information Administration of the US Department of Energy. Over 7 thousand households were surveyed, representing 97 million households nationwide. A second report, to be released in late 1995, will present statistics on residential energy consumption and expenditures.

  6. Juliane House, Translation

    OpenAIRE

    Cappelle, Bert

    2011-01-01

    Many young doctors in linguistics or literature are filling positions in departments of translation studies but might not necessarily have a clear idea of the kind of research carried out by their new-found colleagues. For them, Juliane House's brief introduction to the field of translation theory provides a welcome survey of the main concepts and issues in this area, even though the book is actually intended for readers with little or no background in language study at all.

  7. Planning for seniors housing

    OpenAIRE

    Shiner, Donald

    2012-01-01

    This video clip comprises one of the 3 presentations of Panel Session, “Pan Canadian Policy Perspectives on Home Care" held at the 21st Annual John K. Friesen Conference, "Innovations in Home Care: A Public Policy Perspective," MAY 16-17, 2012, Vancouver, BC. Presented by Donald Shiner, Principle Investigator of the Atlantic Seniors Housing Research Alliance. It is well known that jurisdictions with more comprehensive and integrated home care delivery systems are able to extend indepe...

  8. Housing 'Generation Rent'

    OpenAIRE

    McKee, Kim; Hoolachan, Jennifer Elizabeth

    2015-01-01

    'Generation Rent' denotes young people under 35 who are spending longer periods of their life in the private rented sector (PRS) because of challenges accessing both home ownership and social rented housing1. The 2007 global financial crisis resulted in stricter mortgage lending criteria and larger deposit requirements, which are out of reach for many young people who are navigating difficult labour markets, and have been hit hard by welfare reform agendas2. Furthermore, the shrinkage of the ...

  9. The passive house

    OpenAIRE

    Pascual Sanchis, Isaac

    2011-01-01

    Intercambios internacionales. Jade Hochschule Oldenburg. Alemania. Passive houses are buildings that use resources architecture bioclimatic energy with an efficiency much higher than traditional construction. Buildings are designed to maximize light and heat received from this source of energy, resulting a temperature and humidity comfort, fit and healthy. There are healthy environments at any time of year, without further heat production. Basically, to make this possible, the isolation of...

  10. Ideas about housing

    DEFF Research Database (Denmark)

    Earon, Ofri

    2009-01-01

    This booklet is a project documentation of a short-term project titled ‘IDEAS ABOUT HOUSING Arkitektkonkurrencernes boligløsninger’. Architectural competitions have been used to develop new living concepts reacting on current political, economical and social flows. Participation in an architectur...... investigated: 1950-55, 1970-75 and 1990-95. The purpose of the research is to explore the relationship between the physical space and the social patterns taking place in the modern family home during the investigated time frames.......This booklet is a project documentation of a short-term project titled ‘IDEAS ABOUT HOUSING Arkitektkonkurrencernes boligløsninger’. Architectural competitions have been used to develop new living concepts reacting on current political, economical and social flows. Participation in an architectural......, or to generate solutions to general problem.”2 This architectural investigation looks into the housing concepts presented in architectural competitions, and seeks to analyse the family patterns taking place in the space. The project is an integrated part of a group of projects working on...

  11. 2002 Kuiper prize lecture: Dust Astronomy

    Science.gov (United States)

    Grün, Eberhard; Srama, Ralf; Krüger, Harald; Kempf, Sascha; Dikarev, Valeri; Helfert, Stefan; Moragas-Klostermeyer, Georg

    2005-03-01

    Dust particles, like photons, carry information from remote sites in space and time. From knowledge of the dust particles' birthplace and their bulk properties, we can learn about the remote environment out of which the particles were formed. This approach is called "Dust Astronomy" which is carried out by means of a dust telescope on a Dust Observatory in space. Targets for a dust telescope are the local interstellar medium and nearby star forming regions, as well as comets and asteroids. Dust from interstellar and interplanetary sources is distinguished by accurately sensing their trajectories. Trajectory sensors may use the electric charge signals that are induced when charged grains fly through the detector. Modern in-situ dust impact detectors are capable of providing mass, speed, physical and chemical information of dust grains in space. A Dust Observatory mission is feasible with state-of-the-art technology. It will (1) provide the distinction between interstellar dust and interplanetary dust of cometary and asteroidal origin, (2) determine the elemental composition of impacting dust particles, and (3) monitor the fluxes of various dust components as a function of direction and particle masses.

  12. Theoretical aspects of Dust in fusion devices

    International Nuclear Information System (INIS)

    It is known that micro-particles (dust) exist in fusion devices. However, an impact of dust on plasma contamination, material migration, and performance of fusion devices is still under debate. In burning plasma experiments like ITER dust can also pose safety problems related to it's chemical activity, toxicity, tritium retention, and radioactive content. In order to address all these issues we need to understand the physics of dust generation, dynamics, and transport. In this paper, the results of recent theoretical studies of dust in fusion plasmas are reviewed. Different aspects of the physics of dust in fusion plasmas, including the processes of dust generation, charging, heating, destruction, spinning, forces acting on dust, dust collision with material walls, etc are discussed. The numerical models of these processes have been incorporated into the dust transport code DUSTT, which is capable of tracking of dust particles in fusion devices in 3D geometry. The results of the simulations of dust particle dynamics, transport, and the impact on edge plasma performance are considered. The latest results on nonlinear interactions of dust grain with tokamak plasma as well as remaining gaps in the understanding of physics of dust in fusion devices are discussed (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  13. 77 FR 70177 - Multifamily Housing Mortgage and Housing Assistance Restructuring Program (Mark to Market)

    Science.gov (United States)

    2012-11-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT Multifamily Housing Mortgage and Housing Assistance Restructuring Program (Mark to...: Multifamily Housing Mortgage and Housing Assistance Restructuring Program (Mark to Market). OMB...

  14. House Prices and Public Debt

    DEFF Research Database (Denmark)

    Gjedsted Nielsen, Mads; Rzeznik, Aleksandra

    house price in the municipality. Furthermore, I document that the aggregate house price loss of 2.1 billion DKK greatly exceeds the increase in public debt of 1 billion DKK. I find that the drop in house prices is sustained 1 year, indicating that the housing market initially overreacts but the......By using the 2002 case of fraud in the Danish municipality Farum by then mayor Peter Brixtofte as an exogenous shock to public debt of 1 billion DKK, I estimate the effect of public debt on house prices. I find that the average home ownership lost about 570,000 DKK or as much as 29% of the average...

  15. American Culture Reflected in American English

    Institute of Scientific and Technical Information of China (English)

    李华芳

    2013-01-01

    Language is a vehicle for culture. It is also a key component of culture. It not only reflects culture but also influences culture. As a variety of British English, American English, especially American words and expressions can reflect American culture from many aspects. This paper studies some typical traits of American culture reflected in words and expressions of American Eng-lish.

  16. Dust characterization in FTU tokamak

    Energy Technology Data Exchange (ETDEWEB)

    De Angeli, M., E-mail: deangeli@ifp.cnr.it [Istituto di Fisica del Plasma – Consiglio Nazionale delle Ricerche, Milan (Italy); Maddaluno, G. [ENEA Unità Tecnica Fusione, C.R. ENEA Frascati, CP65, 00044 Frascati (Italy); Laguardia, L. [Istituto di Fisica del Plasma – Consiglio Nazionale delle Ricerche, Milan (Italy); Ripamonti, D. [Istituto per l’Energetica e le Interfasi – Consiglio Nazionale delle Ricerche, Milan (Italy); Perelli Cippo, E. [Istituto di Fisica del Plasma – Consiglio Nazionale delle Ricerche, Milan (Italy); Apicella, M.L. [ENEA Unità Tecnica Fusione, C.R. ENEA Frascati, CP65, 00044 Frascati (Italy); Conti, C. [Istituto per la Conservazione e la Valorizzazione dei Beni Culturali – CNR, Milan (Italy); Giacomi, G. [ENEA Unità Tecnica Fusione, C.R. ENEA Frascati, CP65, 00044 Frascati (Italy); Grosso, G. [Istituto di Fisica del Plasma – Consiglio Nazionale delle Ricerche, Milan (Italy)

    2015-08-15

    Dust present in the vessel of FTU has been collected and analysed. Being FTU a device with full metal plasma facing components for the whole life and equipped with a liquid lithium limiter (LLL) make FTU of special interest from a point of view of dust studies. Analyses were conducted by standard dust analysis methods and by dedicated analysis, as X-rays and neutron diffraction, to investigate the presence of lithium compounds due the presence of the LLL in FTU. Dust collected near the LLL presents a different elemental composition, namely Li compounds, compared to the dust collected in the rest of the vessel; in particular LiO{sub 2}, LiOH, and Li{sub 2}CO{sub 3}. On the basis of these results, the formation of Li{sub 2}CO{sub 3} is proposed via a two steps process. Results of fuel retention measured by thermal desorption spectroscopy (TDS) method show that fuel retention should not be an issue for FTU.

  17. Dust near luminous ultraviolet stars

    Science.gov (United States)

    Henry, Richard C.

    1993-01-01

    This report describes research activities related to the Infrared Astronomical Satellite (IRAS) sky survey. About 745 luminous stars were examined for the presence of interstellar dust heated by a nearby star. The 'cirrus' discovered by IRAS is thermal radiation from interstellar dust at moderate and high galactic latitudes. The IRAS locates the dust which must (at some level) scatter ultraviolet starlight, although it was expected that thermal emission would be found around virtually every star, most stars shown no detectable emission. And the emission found is not uniform. It is not that the star is embedded in 'an interstellar medium', but rather what is found are discrete clouds that are heated by starlight. An exception is the dearth of clouds near the very hottest stars, implying that the very hottest stars play an active role with respect to destroying or substantially modifying the dust clouds over time. The other possibility is simply that the hottest stars are located in regions lacking in dust, which is counter-intuitive. A bibliography of related journal articles is attached.

  18. Differential dust attenuation in CALIFA galaxies

    Science.gov (United States)

    Vale Asari, N.; Cid Fernandes, R.; Amorim, A. L.; Lacerda, E. A. D.; Schlickmann, M.; Wild, V.; Kennicutt, R. C.

    2016-06-01

    Dust attenuation has long been treated as a simple parameter in SED fitting. Real galaxies are, however, much more complicated: The measured dust attenuation is not a simple function of the dust optical depth, but depends strongly on galaxy inclination and the relative distribution of stars and dust. We study the nebular and stellar dust attenuation in CALIFA galaxies, and propose some empirical recipes to make the dust treatment more realistic in spectral synthesis codes. By adding optical recombination emission lines, we find better constraints for differential attenuation. Those recipes can be applied to unresolved galaxy spectra, and lead to better recovered star formation rates.

  19. Chemical Associations of Lead, Cadmium, Chromium, Nickel and Zinc in Household Dust of Kathmandu Metropolitan Area

    International Nuclear Information System (INIS)

    Dust samples were collected from roadside houses of seven major locations in Kathmandu metropolitan area and trace element compositions was determined by atomic absorption spectrophotometer (AAS). Results show significant concentrations of Zn, Pb, Ni, Cr and Cd in the test household dusts as compared to the undisturbed (control) area. The mean concentrations of all the studied locations were found to be 76.2 mg/kg for Zn, 40.6 mg/kg for Pb, 29.9 mg/kg for Cr, 23.9 mg/kg for Ni and 8.2 mg/kg for Cd, respectively. Increase in these trace metals in the dust can most likely be attributed to rapid urbanization, increased vehicle emissions to the atmosphere and other anthropogenic sources. Elevated Zn abundance in household dust probably originates from traffic sources. Besides, enrichment factor reveals that the household dust was most severely affected by Cd in almost all the locations. Also, correlations between metal levels in dust samples for all the metals were investigated. (author)

  20. How the Sociology of Housing Emerged

    OpenAIRE

    Musil, Jiri

    2005-01-01

    The article attempts to examine the main topics in the sociological study of housing from the end of the Second World War to the 1980s & distinguishes the following five: (1) housing systems & housing policy, (2) the relationship between social stratification & housing differentiation, (3) the relationship between the family & housing, (4) the relationship between housing & neighbourhoods, & (5) housing & architecture as components of culture. During this period the sociological study of hous...