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Sample records for amending regulation ec

  1. AMENDING REGULATION (EC NO.1346/2000 ON INSOLVENCY PROCEEDINGS - SOLVING DEFICIENCIES OR ATTEMPT TO RESCUE COMPANIES IN DIFFICULTY?

    Directory of Open Access Journals (Sweden)

    GABRIELA FIERBINŢEANU

    2013-05-01

    Full Text Available EC Insolvency Regulation claims, after more than 10 years, several changes imposed by some of the issues raised by the practice of its application but also by the need to promote economic recovery for enterprises in difficulty in the current economic crisis. This paper analyzes the major segments of change and aims to determine whether these segments provide a coherent answer for the practical difficulties faced by the EC Regulation and whether extending its scope by revising the definition of insolvency proceedings may offer better chances of recovery for the enterprises in difficulty.

  2. [Regulation (EC) No. 1394/2007 on advanced therapy medicinal products : Incorporation into national law].

    Science.gov (United States)

    Dwenger, A; Strassburger, J; Schwerdtfeger, W

    2010-01-01

    Regulation (EC) No. 1394/2007 has created a new legal framework for advanced therapy medicinal products (gene therapy medicinal products, somatic cell therapy medicinal products and tissue engineered products). The Regulation is directly applicable in the Member States of the European Union and, in principle, requires no incorporation into national law. However, the amendment of Directive 2001/83/EC, which results from Regulation (EC) No. 1394/2007, has created a need for incorporation into and amendment of the German Medicinal Products Act. This is one of the objectives of the 15th amendment of the German Medicinal Products Act. In particular, the definition "advanced therapy medicinal products" and the special provisions for advanced therapy medicinal products prepared on a non-routine basis, which are based on the special provisions contained in Art. 28 No. 2 of Regulation (EC) No. 1394/2007, are to be incorporated into the German Medicinal Products Act. These special provisions will be explained in detail.

  3. Environmental policies and regulations on the electricity market in EC

    International Nuclear Information System (INIS)

    The use of natural resources like ground and water, the emissions of noxious gases and particles, the thermal rejections, the production of waste and the noise are the main environmental impacts associated with the production of electricity. Emission regulations and standards have been selected so far by the European Community (EC) and the different Member States to deal with the abatement problem. They simply consist in defining some ceilings or regulations for the different types of noxious gases and particles which are emitted by power plants and forcing the power generation companies to comply with these norms within some pre-determined time period. They can also take the form of a general constraint on the sulfur content of the fuel, for example. Tables of emission limits for various gases from existing and new plants are presented. 3 figs., 8 tabs

  4. EVALUATION OF THE INFLUENCE OF PIG HAM POST – SLAUGHTERING REFRIGERATION ON HYGIENIC PARAMETERS SET IN REGULATION EC 2073/2005

    OpenAIRE

    L. Bassi; S. Bonardi; Brutti, A; C. Bacci; Boni, E; I. Alpigiani; Brindani, F.

    2011-01-01

    In order to evaluate the influence of refrigeration on hygienic parameters, issued by EC Regulation n. 2073:2005 (amended by EC Regulation n. 1441:2007) for swine carcasses, 15 pig hams were tested for microbiological analysis, i.e. enumeration of microorganisms at 30°C and enumeration of enterobacteriacee. Ham swabbing was carried out at the end of slaughtering and after 24 hours of storing in refrigeration cells. The temperature-monitoring recorders were put in the hams at the end of cu...

  5. AMENDMENTS TO THE STAFF RULES AND REGULATIONS

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows as from : 1 January 2001 Scale of basic salaries and scale of basic stipends (Annex R A 1 and Annex R A 2 respectively). These scales include the correction approved in June 2001 of the discrepancy of 0.3% in the net salary adjustment on 1 January 2001. Family Allowance and Child Allowance (Annex R A 4). Reimbursement of education fees (Article R A 8.01) for the academic year 2000/2001, i.e. with effect from 1 September 2000. Periodic reviews of the financial conditions of members of the personel (Annex A1). 1 July 2001 Various drafting amendments adopted in order to ensure greater coherence between the texts, the procedures and actual practice. 1 September 2001 Implementation of the new career structure. Copies of these updates are available in the divisional secretariats.

  6. 78 FR 67225 - Amendments to Material Control and Accounting Regulations

    Science.gov (United States)

    2013-11-08

    ... COMMISSION 10 CFR Parts 40, 70, 72, 74, and 150 RIN 3150-AI61 Amendments to Material Control and Accounting... Commission (NRC) is proposing to amend its regulations for material control and accounting (MC&A) of special... for control and accounting of SNM that is held by a licensee. The MC&A regulations ensure that...

  7. Amendments to the Staff Rules and Regulations

    CERN Document Server

    Human Resources Department

    2005-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows as from 1 July 2005 : Article R II 4.07 of the Staff Regulations - Leave year (pages 25 & 26) The purpose of the amendment is to allow certain members of the personnel, on an exceptional basis in the context of LHC construction, to carry forward more than 30 days of annual leave into the following year. This possibility of additional carry-forward, which will be used sparingly, is governed by strict conditions : i.e. it must be with the consent of the member of the personnel concerned and subject to a specific, documented request by the hierarchy and a favourable medical opinion. In addition, the number of additional days of leave that can be carried forward must not exceed 10 per leave year, and all days of leave accumulated in this way must be used before 30 September 2009. Finally, this possibility will not be available to members of the personnel taking part in the Saved Leave Scheme (SLS) as at 3...

  8. Developmental regulation of ecdysone receptor (EcR and EcR-controlled gene expression during pharate-adult development of honeybees (Apis mellifera.

    Directory of Open Access Journals (Sweden)

    Tathyana Rachel Palo Mello

    2014-12-01

    Full Text Available Major developmental transitions in multicellular organisms are driven by steroid hormones. In insects, these, together with juvenile hormone (JH, control development, metamorphosis, reproduction and aging, and are also suggested to play an important role in caste differentiation of social insects. Here, we aimed to determine how EcR transcription and ecdysteroid titers are related during honeybee postembryonic development and what may actually be the role of EcR in caste development of this social insect. In addition, we expected that knocking-down EcR gene expression would give us information on the participation of the respective protein in regulating downstream targets of EcR. We found that in Apis mellifera females, EcR-A is the predominantly expressed variant in postembryonic development, while EcR-B transcript levels are higher in embryos, indicating an early developmental switch in EcR function. During larval and pupal stages, EcR-B expression levels are very low, while EcR-A transcripts are more variable and abundant in workers compared to queens. Strikingly, these transcript levels are opposite to the ecdysteroid titer profile. 20-hydroxyecdysone (20E application experiments revealed that low 20E levels induce EcR expression during development, whereas high ecdysteroid titers seem to be repressive. By means of RNAi-mediated knockdown (KD of both EcR transcript variants we detected the differential expression of 234 poly-A+ transcripts encoding genes such as CYPs, MRJPs and certain hormone response genes (Kr-h1 and ftz-f1. EcR-KD also promoted the differential expression of 70 miRNAs, including highly conserved ones (e.g. miR-133 and miR-375, as well honeybee-specific ones (e.g. miR-3745 and miR-3761. Our results put in evidence a broad spectrum of EcR-controlled gene expression during postembryonic development of honeybees, revealing new facets of EcR biology in this social insect.

  9. Evaluation of EU Risk assessments Existing Chemicals (EC Regulation 793/93)

    NARCIS (Netherlands)

    Bodar CWM; Berthault F; Bruijn JHM de; Leeuwen CJ van; Pronk MEJ; Vermeire TG; CSR

    2002-01-01

    An evaluation was performed on the first group (41) of completed risk assessments for chemicals of the EU priority lists (Existing Chemicals; EC Regulation 793/93). The evaluation focussed on the conclusions of the risk assessments. The EU risk assessment process detected a high number of substance

  10. Judicial Protection in the Field of Public Procurement: The Transposition into Dutch Law of Directive 2007/66/EC Amending the Remedies Directives

    Directory of Open Access Journals (Sweden)

    Wouter-Jan Berends

    2010-08-01

    Full Text Available Public procurement procedures in the EU are coordinated by Directives 2004/17/EC and 2004/18/EC. The acquis communautaire provides minimum requirements for review procedures against public procurement decisions in order to ensure access to effective remedies for economic operators. These minimum requirements are established in Directives 89/665/ EEC and 92/13/EEC and recently amended by Directive 2007/66/EC. The Helby report identified several substantive concerns over the Dutch proposal on the implementation the of the Remedies Directive; Wet implementatie rechtsbeschermingsrichtlijnen. Although the transposition target date has not been met, the Dutch legislature has succeeded to transpose Directive 2007/66/EC into Dutch law while addressing the concerns of the Helby report.

  11. 75 FR 59094 - Federal Travel Regulation; Miscellaneous Amendments

    Science.gov (United States)

    2010-09-27

    ...-0017; Sequence 1] RIN 3090-AJ07 Federal Travel Regulation; Miscellaneous Amendments AGENCY: Office of... the Federal Travel Regulation (FTR) by updating statutory references in a number of sections, by providing additional guidance for determining distance measurements when traveling by privately...

  12. 76 FR 55273 - Federal Travel Regulation; Per Diem, Miscellaneous Amendments

    Science.gov (United States)

    2011-09-07

    ... approaches that maximize net benefits (including potential economic, environmental, public health and safety... Case 2011-301; Docket 2011-0018, Sequence 1] RIN 3090-AJ11 Federal Travel Regulation; Per Diem...: Interim rule with request for comments. SUMMARY: GSA is amending the Federal Travel Regulation (FTR)...

  13. Study on the impact of regulation (EC) No 1/2005 on the protec-tion of animals during transport

    NARCIS (Netherlands)

    Baltussen, W.H.M.; Gebrensbet, G.; Roest, de K.

    2011-01-01

    The objective of the findings of an evaluation of Regulation (EC) 1/2005 was to provide a detailed assessment of the implementation of the Regulation (EC) and its impact on the animals being transported and on operators, with special reference to trade flows, navigation systems and the socio‐economi

  14. pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Nerthus ApS, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Denmark, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scie......Following an application from Nerthus ApS, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Denmark, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...... considers that the food is sufficiently characterised. An increase in the number of motile spermatozoa in semen is a beneficial physiological effect. In weighing the evidence, the Panel took into account that one human study showed an increase in the number of motile spermatozoa in semen when...

  15. 78 FR 69543 - Amendments to General Regulations of the Food and Drug Administration; Technical Amendments

    Science.gov (United States)

    2013-11-20

    ... Federal Register of November 30, 2010 (75 FR 73951), we amended certain regulations in part 1 (21 CFR part... products under the Tobacco Control Act (75 FR 73951 at 73952). However, the revisions inadvertently created... to section 302 of the Federal Food, Drug, and Cosmetic Act (FD&C Act) (21 U.S.C. 332); Revised Sec....

  16. 13 CFR 107.30 - Amendments to Act and regulations.

    Science.gov (United States)

    2010-01-01

    .... 107.30 Section 107.30 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Introduction to Part 107 § 107.30 Amendments to Act and regulations. A Licensee shall be subject to all existing and future provisions of the Act and parts 107 and 112 of title 13 of the Code...

  17. Amendments to the Staff Rules and Regulations

    CERN Multimedia

    2004-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows as from 1 January 2004: • Preliminary note - Terminology realignment following the restructuring of the Organization (page - i -) • Annex R A 1 - Scale of basic salaries (page 73) • Annex R A 2 - Scale of stipends paid to fellows (page 74) • Annex R A 4 - Family allowance and child allowance (page 81) • Annex R A 8.01 - Reimbursement of education fees for the academic year 2003/2004, i.e. with effect from 1 September 2003 (page 81). Copies of this update, announced in Weekly Bulletin 3/2004, are available in the departmental secretariats. In addition, Staff Rules and Regulations are available for consultation on the Web at http://cern.ch/hr-div/internal/admin_services/rules/default.asp Human Resources Department Tel. 74128

  18. Amendments to the Staff Rules and Regulations

    CERN Multimedia

    2003-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows : as from 1 July 2002 Article R IV 1.41 - Method of adjustment of the amount of subsistence indemnity (page 53) as from 1 January 2003 Annex R A 1 - Scale of basic salaries (page 73) Annex R A 2 - Scale of stipends paid to fellows (page 74) Annex R A 4 - Family allowance and child allowance (page 81) Annex R A 8.01 - Reimbursement of education fees for the academic year 2002/2003, i.e. with effect from 1 September 2002 (page 81). Copies of this update, announced in Weekly Bulletin 4/2003, are available in the divisional secretariats. In addition, Staff Rules and Regulations are available for consultation on the Web at : http://cern.ch/hr-div/internal/admin_services/rules/default.asp Human Resources Division Tel. 74128

  19. Amendments to the Staff Rules and Regulations

    CERN Document Server

    Human Resources Department

    2005-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows as from 1 January 2005 : Annex R A 1 - Scale of basic salaries (page 73) Annex R A 2 - Scale of stipends paid to fellows (page 74) Annex R A 4 - Family allowance and child allowance (page 81) Annex R A 8.01 - Reimbursement of education fees for the academic year 2004/2005, i.e. with effect from 1 September 2004 (page 81). Copies of this update, announced in Weekly Bulletin 4/2005, are available in the departmental secretariats. In addition, Staff Rules and Regulations are available for consultation on the Web at http://cern.ch/hr-div/internal/admin_services/rules/default.asp Human Resources Department Tel. 74128

  20. AMENDMENTS TO THE STAFF RULES AND REGULATIONS

    CERN Document Server

    Human Resources Division

    2002-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows as from 1 January 2002: Annex R A 1 - Scale of basic salaries (page 73). Annex R A 2 - Scale of stipends paid to fellows (page 74). Annex R A 4 - Family allowance and child allowance (page 81). Annex R A 8.01 - Reimbursement of education fees for the academic year 2001/2002, i.e. with effect from 1 September 2001 (page 81). Copies of this update, announced in Weekly Bulletin 4/2002, are available in the divisional secretariats. In addition, Staff Rules and Regulations are available for consultation on the Web HERE Human Resources Division Tel. 74128

  1. Amendments to the Staff Rules and Regulations

    CERN Multimedia

    HR Department

    2006-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows as from 1 July 2006: The modifications are listed below: Financial and social conditions for Paid Associates, Fellows and Students (introduction of a new payment scheme for the Paid Scientific Associates Programme - reorganization of the Fellowship Programme - modification of the Student subsistence rates) Protection of members of the personnel against the financial consequences of illness, accident and disability (clarification of the scope of the relevant provisions - new definition of disability and associated benefits - revised role of the Joint Advisory Rehabilitation and Disability Board - bringing together the relevant provisions). Copies of this update (modification# 16) are available in departmental secretariats. In addition, Staff Rules and Regulations are available for consultation on the Web at the following address: http://cern.ch/hr-div/internal/admin_services/rules/default.asp Administrative Circular ...

  2. Amendments to the Staff Rules and Regulations

    CERN Multimedia

    HR Department

    2006-01-01

    The Staff Rules and Regulations in force since 1st January 1996 are modified as follows as of 1st July 2006: Financial and social conditions for Paid Associates, Fellows and Students (introduction of a new payment scheme for the Paid Scientific Associates Programme-reorganisation of the Fellowship Programme-modification of Student subsistence rates) Protection of members of the personnel against the financial consequences of illness, accident and disability (clarification of the scope of the relevant provisions-new definition of disability and associated benefits-revised role of the Joint Advisory Rehabilitation and Disability Board-bringing together of the relevant provisions). Copies of this update (modification No.16) are available from Departmental secretariats. In addition, the Staff Rules and Regulations can be consulted on the Web at the following address: http://cern.ch/hr-div/internal/admin_services/rules/default.asp Administrative Circular No. 14 (Rev. 2)-July 2006 Protection of members o...

  3. 78 FR 44806 - Amendments to Regulation D, Form D and Rule 156

    Science.gov (United States)

    2013-07-24

    ...-13] RIN 3235-AL46 Amendments to Regulation D, Form D and Rule 156 AGENCY: Securities and Exchange... releases amended Rule 506 of Regulation D, Form D and Rule 144A under the Securities Act of 1933 to... Regulation D, Form D and Rule 156 under the Securities Act. These proposed amendments are intended to...

  4. Amendments to the Staff Rules and Regulations

    CERN Multimedia

    HR Department

    2006-01-01

    The Staff Rules and Regulations in force since 1 January 1996 are modified as follows as from : 1 January 2005 Internal taxation of remuneration, payments and other financial benefits (New articles IV 2.01, R IV 2.01 to 2.04 pages 56 bis & 56 ter; Annex R A 1 bis page 73 bis) 1 September 2005 Reimbursement of education fees (Article R A 8.01 page 81) for the academic year 2005/2006 1 November 2005 Age limit (Article R II 6.04 page 37) 1 January 2006 Scale of basic salaries and scale of basic stipends (Annex R A 1 page 73 & Annex R A 2 page 74 respectively). Family Allowance and Child Allowance (Annex R A 4 page 76) New contract policy for staff members (Articles R II 1.19 & 1.20 page 15, R II 1.23 page 16, II 6.01 page 36, R II 6.02 & R II 6.06 page 37, VIII 1.03 page 68, R A 9.01 page 83). Copies of this update (modification # 15) are available in departmental secretariats. In addition, Staff Rules and Regulations are available for consultation on the Web at the following addr...

  5. Statutory Instrument No. 205, The Food (Control of irradiation) (Amendment) Regulations 1972

    International Nuclear Information System (INIS)

    These Regulations amend the Food (Control of Irradiation) Regulations 1967, which had already been amended by 1969 Regulations. The purpose of the present modification is to increase the low level of irradiation that is permitted under the regulations from 10 rad to 50 rad. These Regulations also revoke the 1969 Regulations (NEA)

  6. Statutory Instrument No. 307 (S.21) The Food (Control of irradiation) (Scotland) Amendment Regulations 1972

    International Nuclear Information System (INIS)

    These Regulations amend the Food (Control of Irradiation) (Scotland) Regulations 1967, which had already been amended by 1969 Regulations. The purpose of the present modification is to increase the low level of irradiation that is permitted under the regulations from 10 rad to 50 rad. These regulations also revoke the 1969 Regulations. (NEA)

  7. Proposed general amendments to the atomic energy control regulations

    International Nuclear Information System (INIS)

    Canada's Atomic Energy Control Act defines the powers and responsibilities of the Atomic Energy Control Board (AECB). Among these is to make regulations to control the development, application and use of atomic energy. In these proposed general amendments to the Atomic Energy Control Regulations substantial changes are proposed in the designation of the authority of AECB staff, exemptions from licensing, international safeguards, duties of licensees and atomic radiation workers, security of information, and provision for hearings. The scope of the control of atomic energy has been redefined as relating to matters of health, safety, security, international safeguards, and the protection of the environment

  8. Amended EC Directive on the limitation of emissions of certain pollutants into the air from large combustion plants. Implications for German power plants; Neue EG-Richtlinie fuer Grossfeuerungsanlagen. Folgerungen fuer deutsche Kraftwerke

    Energy Technology Data Exchange (ETDEWEB)

    Hildebrand, M. [Verband der Elektrizitaetswirtschaft - VDEW - e.V., Frankfurt (Germany). Bereich Recht und Umwelt

    2002-03-11

    The article highlights the major improvements in terms of reducing emissions from large combustion plants, comparing the new limiting values and specifications with those of the former Directive. As Germany is obliged to transform the new EC Directive into national law within twelve months from its entry into force, an amendment of the respective German regulation can be expected soon. (orig./CB) [German] Mit der im Herbst 2001 durch das Europaeische Parlament und den Umweltministerrat verabschiedeten Novelle der Grossfeuerungsanlagen-Richtlinie hat die Europaeische Union einen markanten, laengst ueberfaelligen Schritt zur EU-weiten Angleichung der emissionsseitigen Anforderungen an grosse Feuerungsanlagen unternommen. Mit dem Inkrafttreten der novellierten Grossfeuerungsanlagen-Richtlinie wurde aber auch der formale Anstoss fuer eine Aktualisierung der deutschen Grossfeuerungsanlagen-Verordnung (13.BImSchV) gegeben. (orig./CB)

  9. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific and technical guidance for the preparation and presentation of applications pursuant to Article 6 Paragraph 11 of Directive 2000/13/EC, as amended

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on Scientific and technical guidance for the preparation and presentation of applications pursuant to Article 6 Paragraph 11 of Directive 2000....../13/EC, as amended. This guidance applies to food ingredients or substances with known allergenic potential listed in Annex IIIa of 2003/89/EC (as amended) or products thereof, and aims to assist applicants in the preparation and presentation of well-structured applications for exemption from labelling...

  10. 76 FR 77115 - Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding...

    Science.gov (United States)

    2011-12-12

    ... Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding of the... Export Administration Regulations (EAR) by moving the substantive provisions of the comprehensive... 746 of the Export Administration Regulations In this rule, the Bureau of Industry and Security...

  11. EFSA guidance on the submission of applications for authorisation of genetically modified plants under Regulation (EC No 1829/2003

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2013-12-01

    Full Text Available This document provides guidance to applicants for submitting an application for authorisation of genetically modified (GM plants for food and feed uses, import and processing, and/or cultivation in the European Union under Regulation (EC No 1829/2003. The EFSA submission guidance describes the community procedures in the European Union for handling GM plant applications, and provides instructions to applicants on how to prepare and present data in an application. It is supplemented with seven appendices providing templates of data presentation to be followed by applicants, including a completeness checklist. The earlier versions are now updated to account for requirements outlined in Implementing Regulation (EU No 503/2013. Instructions for submission described in this EFSA guidance are applicable to all GM plant applications submitted under Articles 5, 11, 17 and 23 of Regulation (EC No 1829/2003.

  12. 75 FR 76319 - Amendments to National Marine Sanctuary Regulations Regarding Low Overflights in Designated Zones

    Science.gov (United States)

    2010-12-08

    ...NOAA proposes to amend the regulations of the Channel Islands, Monterey Bay, Gulf of the Farallones, and Olympic Coast national marine sanctuaries relating to sanctuary overflights. Specifically, NOAA proposes to: amend the regulations requiring that motorized aircraft maintain certain minimum altitudes above specified locations within the boundaries of the listed sanctuaries; and state that......

  13. Sor/88-391, 21 July 1988, uranium mines (Ontario) occupational health and safety regulations, amendment

    International Nuclear Information System (INIS)

    These Regulations (SOR/84-435) were made to establish uniformity in the laws governing occupational health and safety in mines in the Province of Ontario. To ensure conformity, the legal references in the Regulations have been amended to accord with the 1987 amendment of the Ontario Occupational Health and Safety Act

  14. 76 FR 28193 - Amendments to Material Control and Accounting Regulations

    Science.gov (United States)

    2011-05-16

    ... COMMISSION 10 CFR Parts 72, 74, and 150 RIN 3150-AI61 Amendments to Material Control and Accounting... proposed rule language concerning the NRC's proposed amendments to the material control and accounting (MC... FNMC is an outdated term, as it does not include ``accounting,'' and thus does not fully describe...

  15. 78 FR 61222 - Amendments to Regulation D, Form D and Rule 156; Re-Opening of Comment Period

    Science.gov (United States)

    2013-10-03

    .... S7-06-13] RIN 3235-AL46 Amendments to Regulation D, Form D and Rule 156; Re-Opening of Comment Period... amendments to Regulation D, Form D and Rule 156 under the Securities Act in Release No. 33-9416 (July 10... amendments. DATES: The comment period for the proposed rule published at 78 FR 44806 on July 24, 2013,...

  16. and reducing intestinal discomfort pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from PiLeJe, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related...... is "improves intestinal comfort". The Panel considers that reduction of gastro-intestinal discomfort is a beneficial physiological effect. The Panel considers that the only human study provided for the substantiation of the claim (with limitations) did not find an effect of a combination of the bacterial...

  17. 77 FR 74063 - Amendments to the Abandoned Plan Regulations

    Science.gov (United States)

    2012-12-12

    ... and can be retrieved by most Internet search engines. Comments may be submitted anonymously. Comments...\\ \\1\\ 71 FR 20820. See also 73 FR 58459 for subsequent amendments with regard to distributions on behalf of a missing non-spouse beneficiary. \\2\\ 71 FR 20855. For the reasons set forth in the...

  18. 76 FR 76318 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2011-12-07

    ... omitted from a final rule published at 76 FR 58152 on September 20, 2011. This coverage was previously..., Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General at the following... ``(DEC 2011)''. 0 b. Amending the introductory text by removing ``211.274-4(c)'' and adding in its...

  19. Guide to the IET wiring regulations BS 7671:2008 incorporating amendment no 1:2011)

    CERN Document Server

    2012-01-01

    This authoritative, best-selling guide has been extensively updated with the new technical requirements of the IET Wiring Regulations (BS 7671: 2008) Amendment No. 1:2011, also known as the IET Wiring Regulations 17th Edition. With clear description, it provides a practical interpretation of the amended regulations - effective January 2012 - offers real solutions to the problems that can occur in practice. This revised edition features:new material on hot topics such as electromagnetic compatibility (EMC), harmonics, surge protective devices, and new special locations incl

  20. 78 FR 71532 - Amendments to Material Control and Accounting Regulations and Proposed Guidance for Fuel Cycle...

    Science.gov (United States)

    2013-11-29

    ...: I. Background On November 8, 2013 (78 FR 67225; NRC-2009-0096), the NRC published for public comment a proposed rule to amend its regulations for MC&A of SNM. Also on November 8, 2013 (78 FR 67224; NRC... Control and Accounting Regulations and Proposed Guidance for Fuel Cycle Facility Material Control...

  1. Basic substances under EC 1107/2009 phytochemical regulation: experience with non-biocide and food products as biorationals

    Directory of Open Access Journals (Sweden)

    Marchand Patrice A.

    2016-07-01

    Full Text Available Basic Substances are a newly effective category of Plant Protection Product under EC Regulation No 1107/2009. The first approved application of Equisetum arvense L. opened Part C of Implementing Regulation (EU No 540/2011, which lists the basic substance approved. Although E. arvense was described as a fungicide extract, subsequent applications like chitosan were related to non-biocide molecules. Consequently, plant protection product data were collected from research on alternative or traditional crop protection methods. They are notably issued or derived from foodstuffs (plants, plant by-products, plant derived products, substances and derived substances from animal origin. Applications are currently submitted by our Institute, under evaluation at different stages of the approval process or already approved. Remarkably, this Basic Substance category under pesticide EU Regulation was surprisingly designed for these non-biocidal plant protection products. In fact, components described as the “active substance” of most of the actual applications are food products like sugars and lecithin. Basic Substance applications for these foodstuffs are therefore a straightforward way of easily gaining approval for them. Here we describe the approval context and detail the agricultural uses of theses food products as Biological Control Agents (BCAs or biorationals for crop protection. From all deposited or approved Basic Substance Application (BSA, a proof has been provided that non-biocide and food products via physical barrier or lure effects may be effective plant protection products with an acceptable low profile of concern for public and agricultural safety.

  2. 76 FR 16285 - Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To Update Water...

    Science.gov (United States)

    2011-03-23

    ... COMMISSION 18 CFR Part 410 Amendments to the Water Quality Regulations, Water Code and Comprehensive Plan To Update Water Quality Criteria for Toxic Pollutants in the Delaware Estuary and Extend These Criteria to... amendments to its Water Quality Regulations, Water Code and Comprehensive Plan to update the...

  3. 78 FR 18814 - Amendment to the Export Administration Regulations: List of Items Classified Under Export Control...

    Science.gov (United States)

    2013-03-28

    ... controlled for export because the items provide at least a significant military or intelligence advantage to... Bureau of Industry and Security 15 CFR Part 774 RIN 0694-AF73 Amendment to the Export Administration Regulations: List of Items Classified Under Export Control Classification 0Y521 Series--Biosensor...

  4. 76 FR 20569 - Horse Protection Act; Petition for Amendments to Regulations

    Science.gov (United States)

    2011-04-13

    ... Animal and Plant Health Inspection Service 9 CFR Part 11 Horse Protection Act; Petition for Amendments to... changes to our horse protection regulations and our current enforcement practices and related policies... are noting, however, that certain requests in the petition lack authority in the Horse Protection...

  5. 77 FR 64430 - Federal Travel Regulation; Per Diem, Miscellaneous Amendments

    Science.gov (United States)

    2012-10-22

    ..., 2011 (76 FR 55273). C. Executive Order 12866 and Executive Order 13563 Executive Orders (E.O.s) 12866..., which was published in the Federal Register at 76 FR 55273 on September 7, 2011, is adopted as a final... Case 2011-301; Docket 2011-0018, Sequence 1] RIN 3090-AJ11 Federal Travel Regulation; Per...

  6. 75 FR 55292 - Amendment to Egg Research and Promotion Order and Regulations To Increase the Rate of Assessment...

    Science.gov (United States)

    2010-09-10

    ... comments concerning potential effects of these amendments on small businesses (74 FR 48568). Comments on... case was published in the Federal Register on September 25, 2009 (74 FR 48568). Comments were solicited... Agricultural Marketing Service 7 CFR Part 1250 Amendment to Egg Research and Promotion Order and Regulations...

  7. Uranium and thorium mining regulations: Amendments relating to financial assurances and decommissioning of uranium mining facilities. Consultative document

    International Nuclear Information System (INIS)

    The purpose of this document is to describe the objectives, scope, substance and application of proposed amendments to the Uranium and Thorium Mining Regulations; in particular, amendments relating to the provision of financial assurances for the decommissioning of Canadian uranium mines. (author)

  8. Up-regulation of stathmin induces growth arrest of esophageal squamous cell carcinoma EC9706 cell%上调stathmin基因表达对食管鳞癌EC9706细胞的作用

    Institute of Scientific and Technical Information of China (English)

    王峰; 王留兴; 何炜; 李克; 王瑞林; 赵培荣; 樊青霞

    2010-01-01

    proliferation of transfected cells was measured by cell counting, MTT and in vitro formation assay of flat Flow cytometry was used to detect the cell cycle. Nude mice were adopted to investigate the in vivo tumorigenic characteristics of the transfected cells. Results A 450 bp coding sequence of stathmin cDNA was amplified by RT-PCR and then cloned into pcDNA3. 1 ( + ) plasmid to harvest the recombinant plasmid pcDNA3. 1-stathmin. The recombinant plasmid pcDNA3. 1-stathmin and blank vector were transfected respectively into EC9706 cells. The up-regulated expression of stathmin protein was validated by Western blot ( P < 0. 01 ) . Compared with control, EC9706 cells transfected with pcDNA3. 1-stathmin appeared swollen and multi-nuclear with a cell mitotic arrest; doubling generation time of pcDNA3. 1stathmin transfectants was prolonged(25 -28 h); The in vitro cell proliferation ability and clone formation rate (34.5% +-6.9%) decreased, cell cleavage was blocked at G2/M phase (21. 7% +- 3. 4% ) and the oncogenicity of inoculated cells in nude mice decreased ( all P < 0. 01). Conclusions The up-regulated expression of stathmin protein triggered by the recombinant plasmid pcDNA3. 1-stathmin can inhibit the proliferation and oncogenicity of ESCC EC9706 cells. TTiis molecule may be a promising therapeutic target in ESCC patients.

  9. 77 FR 39392 - Amendment to the International Traffic in Arms Regulations: Yemen

    Science.gov (United States)

    2012-07-03

    .... 744 (22 U.S.C. 2752, 2778, 2780, 2791, and 2797); E.O. 11958, 42 FR 4311; 3 CFR, 1977 Comp., p. 79; 22 U.S.C. 2651a; 22 U.S.C. 287c; E.O. 12918, 59 FR 28205; 3 CFR, 1994 Comp., p. 899; Sec. 1225, Pub. L... Part 126 RIN 1400-AD23 Amendment to the International Traffic in Arms Regulations: Yemen...

  10. 77 FR 12201 - Amendment to the International Traffic in Arms Regulations: Haiti

    Science.gov (United States)

    2012-02-29

    .... 744 (22 U.S.C. 2752, 2778, 2780, 2791, and 2797); E.O. 11958, 42 FR 4311; 3 CFR, 1977 Comp., p. 79; 22 U.S.C. 2651a; 22 U.S.C. 287c; E.O. 12918, 59 FR 28205; 3 CFR, 1994 Comp., p. 899; Sec. 1225, Pub. L... Part 126 RIN 1400-AD08 Amendment to the International Traffic in Arms Regulations: Haiti...

  11. 76 FR 30001 - Amendment to the International Traffic in Arms Regulations: Libya

    Science.gov (United States)

    2011-05-24

    ..., 2778, 2780, 2791 and 2797); E.O. 11958, 42 FR 4311; 3 CFR, 1977 Comp., p.79; 22 U.S.C. 2651a; 22 U.S.C. 287c; E.O. 12918, 59 FR 28205; 3 CFR, 1994 Comp., p.899; Sec. 1225, Pub. L. 108-375. 0 2. Section 126.1... Part 126 RIN 1400-AC83 Amendment to the International Traffic in Arms Regulations: Libya...

  12. Reasoned opinion on the review of the existing maximum residue levels (MRLs for dichlobenil according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2013-05-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance dichlobenil. Considering that this active substance is no longer authorised within the European Union, that no MRLs are established by the Codex Alimentarius Commission, and that no import tolerances were notified to EFSA, residues of dichlobenil are not expected to occur in any plant or animal commodity. Available data were also not sufficient to derive a residue definition or an LOQ for enforcement against potential illegal uses for the time being but this assessment may be reconsidered when the future review of MRLs for fluopicolide under the aforementioned regulation (EC No 396/2005 will be carried out because fluopicolide is an authorised pesticide active substance generating a metabolite common to dichlobenil.

  13. Reasoned opinion on the review of the existing maximum residue levels (MRLs) for tritosulfuron according to Article 12 of Regulation (EC) No 396/2005

    OpenAIRE

    European Food Safety Authority

    2015-01-01

    According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance tritosulfuron. In order to assess the occurrence of tritosulfuron residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Memb...

  14. Outcome of the public consultation on the draft guidance for renewal applications of genetically modified food and feed authorised under Regulation (EC) No 1829/2003

    OpenAIRE

    Andersson, Christer; Gropp, Jürgen; Naegeli, Hanspeter; Nogué, Fabien; Rostoks, Nils; Sweet, Jeremy; Dumont, Antonio Fernandez; Gomes, Ana; Mestdagh, Sylvie; Paoletti, Claudia; Ramon, Matthew; Waigmann, Elisabeth

    2015-01-01

    A public consultation on the draft guidance for renewal applications of genetically modified food and feed authorised under Regulation (EC) No 1829/2003 endorsed by the Panel on Genetically Modified Organisms of the European Food Safety Authority was launched on 4 November 2014 and ended on 4 January 2015. The European Food Safety Authority received 114 comments on this draft guidance from 20 interested parties. Through its dedicated working group, the Panel on Genetically Modified Organisms ...

  15. New Regional and Global HFC Projections and Effects of National Regulations and Montreal Protocol Amendment Proposals

    Science.gov (United States)

    Velders, G. J. M.

    2015-12-01

    Hydrofluorocarbons (HFCs) are used as substitutes for ozone-depleting substances that are being phased out globally under Montreal Protocol regulations. New global scenarios of HFC emissions reach 4.0-5.3 GtCO2-eq yr-1 in 2050, which corresponds to a projected growth from 2015 to 2050 which is 9% to 29% of that for CO2 over the same time period. New baseline scenarios are formulated for 10 HFC compounds, 11 geographic regions, and 13 use categories. These projections are the first to comprehensively assess production and consumption of individual HFCs in multiple use sectors and geographic regions with emission estimates constrained by atmospheric observations. In 2050, in percent of global HFC emissions, China (~30%), India and the rest of Asia (~25%), Middle East and northern Africa (~10%), and USA (~10%) are the principal source regions; and refrigeration and stationary air conditioning are the major use sectors. National regulations to limit HFC use have been adopted recently in the European Union, Japan and USA, and four proposals have been submitted in 2015 to amend the Montreal Protocol to substantially reduce growth in HFC use. Calculated baseline emissions are reduced by 90% in 2050 by implementing the North America Montreal Protocol amendment proposal. Global adoption of technologies required to meet national regulations would be sufficient to reduce 2050 baseline HFC consumption by more than 50% of that achieved with the North America proposal for most developed and developing countries. The new HFC scenarios and effects of national regulations and Montreal Protocol amendment proposals will be presented.

  16. 78 FR 63408 - Petition To Amend Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears...

    Science.gov (United States)

    2013-10-24

    ... Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears, and Nonhuman Primates... Animal Welfare Act regulations and standards, including to prohibit licensees from allowing individuals.... SUMMARY: We are reopening the comment period for a petition requesting amendments to the Animal...

  17. The Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) (Amendment No. 2) (Northern Ireland) Regulations 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-09-02

    These Regulations amend the Pneumoconiosis, etc. (Workers' Compensation) (Payment of Claims) Regulations (Northern Ireland) 1988 to provide that certain payments under the Pneumoconiosis, etc. (Workers' Compensation) (Northern Ireland) Order 1979 are reduced by the amount of any lump sum payment in respect of diffuse mesothelioma made under section 1 of the Mesothelioma, etc., Act (Northern Ireland) 2008.

  18. Reasoned opinion on the review of the existing maximum residue levels (MRLs for indolylacetic acid according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-07-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance indolylacetic acid. Considering that this active substance is no longer authorised within the European Union, that no MRLs are established by the Codex Alimentarius Commission, and that no import tolerances were notified to EFSA, residues of indolylacetic acid are not expected to occur in any plant or animal commodity. Available data were also not sufficient to derive a residue definition or a limit of quantification (LOQ for enforcement against potential illegal uses.

  19. Reasoned opinion on the review of the existing maximum residue levels (MRLs for 2-naphthyloxyacetic acid according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2013-07-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance 2-naphthyloxyacetic acid. Considering that this active substance is no longer authorised within the European Union, that no MRLs are established by the Codex Alimentarius Commission, and that no import tolerances were notified to EFSA, residues of 2-naphthyloxyacetic acid are not expected to occur in any plant or animal commodity. Available data were also not sufficient to derive a residue definition or an LOQ for enforcement against potential illegal uses.

  20. Reasoned opinion on the review of the existing maximum residue levels (MRLs for indolylbutyric acid according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-07-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance indolylbutyric acid. Considering that this active substance is not authorised for use on edible crops within the European Union, that no MRLs are established by the Codex Alimentarius Commission, and that no import tolerances were notified to EFSA, residues of indolylbutyric acid are not expected to occur in any plant or animal commodity. Available data were also not sufficient to derive a residue definition or a limit of quantification (LOQ for enforcement against potential illegal uses.

  1. The Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) (Amendment) (Northern Ireland) Regulations 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-04-04

    Under the Pneumoconiosis etc. (Workers' Compensation) Act (Northern Ireland) 1979 ('the Order') lump sum payments may be made to certain persons disabled by a disease to which the Order applies, or to dependants of persons who were so disabled immediately before they died. These Regulations further amend the Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) Regulations (Northern Ireland) 1988 so as to increase the amounts payable under the Order. The increase in each case is 3.9 per cent, rounded up or down to the nearest one pound as appropriate. The diseases to which the Order applies are pneumoconiosis, byssinosis, diffuse mesothelioma, primary carcinoma of the lung (where accompanied by asbestosis or diffuse pleural thickening) and diffuse pleural thickening.

  2. The Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) (Amendment) (Northern Ireland) Regulations 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-21

    Under the Pneumoconiosis etc. (Workers' Compensation) Act (Northern Ireland) 1979 ('the Order') lump sum payments may be made to certain persons disabled by a disease to which the Order applies, or to dependants of persons who were so disabled immediately before they died. These Regulations further amend the Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) Regulations (Northern Ireland) 1988 so as to increase the amounts payable under the Order. The increase in each case is 2.7 per cent, rounded up or down to the nearest one pound as appropriate. The diseases to which the Order applies are pneumoconiosis, byssinosis, diffuse mesothelioma, primary carcinoma of the lung (where accompanied by asbestosis or diffuse pleural thickening) and diffuse pleural thickening. A full regulatory impact assessment has not been produced for this instrument as it has no impact on the costs of business.

  3. The Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) (Amendment) (Northern Ireland) Regulations 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-03-29

    Under the Pneumoconiosis etc. (Workers' Compensation) Act (Northern Ireland) 1979 ('the Order') lump sum payments may be made to certain persons disabled by a disease to which the Order applies, or to dependants of persons who were so disabled immediately before they died. These Regulations further amend the Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) Regulations (Northern Ireland) 1988 so as to increase the amounts payable under the Order. The increase in each case is 3.6 per cent, rounded up or down to the nearest one pound as appropriate. The diseases to which the Order applies are pneumoconiosis, byssinosis, diffuse mesothelioma, primary carcinoma of the lung (where accompanied by asbestosis or diffuse pleural thickening) and diffuse pleural thickening. A full regulatory impact assessment has not been produced for this instrument as it has no impact on the costs of business, charities or voluntary bodies.

  4. The Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) (Amendment) Regulations 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-23

    Under the Pneumoconiosis etc. (Workers' Compensation) Act 1979 'the Act' lump sum payments may be made to certain persons disabled by a disease to which the Act applies, or to dependants of persons who were so disabled immediately before they died. These Regulations amend the Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) Regulations 1988, so as to increase the amount payable under the Act. The increase in each case is 2.7 per cent, rounded up or down to the nearest one pound as appropriate. The diseases to which the Act applies are pneumoconiosis, byssinosis, diffuse mesothelioma, primary carcinoma of the lung (where accompanied by asbestosis or diffuse pleural thickening) and diffuse pleural thickening. A full regulatory impact assessment has not been produced for this instrument as it has no impact on the cost of business.

  5. The Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) (Amendment) Regulations 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-03-13

    Under the Pneumoconiosis etc. (Workers' Compensation) Act 1979 'the Act' lump sum payments may be made to certain persons disabled by a disease to which the Act applies, or to dependants of persons who were so disabled immediately before they died. These Regulations amend the Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) Regulations 1988 (SI 1988/668), so as to increase the amount payable under the Act. The increase in each case is 3.6 per cent, rounded up or down to the nearest one pound as appropriate. The diseases to which the Act applies are pneumoconiosis, byssinosis, diffuse mesothelioma, primary carcinoma of the lung (where accompanied by asbestosis or diffuse pleural thickening) and diffuse pleural thickening. A full regulatory impact assessment has not been produced for this instrument as it has no impact on the cost of business, charities and voluntary bodies.

  6. The Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) (Amendment) Regulations 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-03-14

    Under the Pneumoconiosis etc. (Workers' Compensation) Act 1979 'the Act' lump sum payments may be made to certain persons disabled by a disease to which the Act applies, or to dependants of persons who were so disabled immediately before they died. These Regulations amend the Pneumoconiosis etc. (Workers' Compensation) (Payment of Claims) Regulations 1988 (SI 1988/668), so as to increase the amount payable under the Act. The increase in each case is 3.9 per cent, rounded up or down to the nearest one pound as appropriate. The diseases to which the Act applies are pneumoconiosis, byssinosis, diffuse mesothelioma, primary carcinoma of the lung (where accompanied by asbestosis or diffuse pleural thickening) and diffuse pleural thickening. A full regulatory impact assessment has not been produced for this instrument as it has no impact on the cost of business, charities and voluntary bodies.

  7. Directive2001-83-EC关于传统草药的具体规定%Detailed regulations about traditional herbal medicines in Directive 2001-83-EC

    Institute of Scientific and Technical Information of China (English)

    黄宇虹; 张伯礼

    2011-01-01

    Directive 2001-83-EC is a primary part of the EU laws and regulations relevant to drugs used in human.The Directive 2001-83-EC published firstly in Nov.6, 2001 has being used to supervise the manufacture,distribution and administration of medical products in order to protect the public health and promote drug development.Up to date, it has been revised seven times.This article, according to the third part of the Directive 2001-83-EC published in Dec.30.2008, introduces the detailed regulations about traditional herbal registration in EU.The goal is to offer information for Chinese researchers, sponsors and other persons who are interested in registering Chinese traditional medicines in EU and intend to get approval.%2001-83号法令是欧盟人用药物相关法令中的基本大法.该法令于2001年11月6日第一次颁布,主要是用于监管药品生产、流通、使用环节,以保证公众健康和促进药品研发.到目前为止已经修订了7次.本文依据2008年12月30日版中第三大部分内容,详细介绍了传统植物药在欧盟注册的法规要求,以期为国内的研究者、企业(申办者)及其他致力于传统中草药在欧盟注册并期望获得批准的有志者提供些许信息支持.

  8. Has gambling changed after major amendments of gambling regulations in Germany? A propensity score analysis.

    Science.gov (United States)

    Ludwig, Monika; Kraus, Ludwig; Müller, Stefanie; Braun, Barbara; Bühringer, Gerhard

    2012-12-01

    Aims This study examined changes in general population gambling in the light of two major amendments of the German gambling regulation, the Fifth Amendment of the German Gambling Ordinance (AGO) for commercial amusement machines with prizes (AWP) and the State Treaty on Gambling (STG) for gambling activities subject to the state monopoly. Methods Applying cross-sectional data from the 2006 and 2009 Epidemiological Survey of Substance Abuse (ESA), propensity-score-matched samples of 7,970 subjects and 3,624 12-month gamblers aged 18-64 years were used for analyses. Logistic regression was employed to examine changes in gambling controlling for possible confounding variables. Results Overall participation in state gambling activities, participation in lotto as well as TV lottery decreased and gambling on Internet card games increased. No changes were found for any other gambling activity, 12-month prevalence of any gambling and pathological gambling. While weekly gambling declined, overall multiple gambling increased. Effects were similar in the total sample and among current gamblers. Conclusions Prohibiting specific gambling activities, e.g., Internet gambling, seem to be insufficient approaches to change gambling behavior. Supply reduction might need to be enhanced by changes in game characteristics and implementation of early intervention measures. However, long-term consequences are uncertain and further monitoring is needed.

  9. Has gambling changed after major amendments of gambling regulations in Germany? A propensity score analysis.

    Science.gov (United States)

    Ludwig, Monika; Kraus, Ludwig; Müller, Stefanie; Braun, Barbara; Bühringer, Gerhard

    2012-12-01

    Aims This study examined changes in general population gambling in the light of two major amendments of the German gambling regulation, the Fifth Amendment of the German Gambling Ordinance (AGO) for commercial amusement machines with prizes (AWP) and the State Treaty on Gambling (STG) for gambling activities subject to the state monopoly. Methods Applying cross-sectional data from the 2006 and 2009 Epidemiological Survey of Substance Abuse (ESA), propensity-score-matched samples of 7,970 subjects and 3,624 12-month gamblers aged 18-64 years were used for analyses. Logistic regression was employed to examine changes in gambling controlling for possible confounding variables. Results Overall participation in state gambling activities, participation in lotto as well as TV lottery decreased and gambling on Internet card games increased. No changes were found for any other gambling activity, 12-month prevalence of any gambling and pathological gambling. While weekly gambling declined, overall multiple gambling increased. Effects were similar in the total sample and among current gamblers. Conclusions Prohibiting specific gambling activities, e.g., Internet gambling, seem to be insufficient approaches to change gambling behavior. Supply reduction might need to be enhanced by changes in game characteristics and implementation of early intervention measures. However, long-term consequences are uncertain and further monitoring is needed. PMID:26165602

  10. Royal Order of 5 December 1975 amending the Royal Order of 11 May 1971 embodying the general Military Regulations for Protection Against the Hazards of Ionizing Radiations

    International Nuclear Information System (INIS)

    This Royal Order amends the Royal Order on general Military Regulations for Protection against the Hazards of Ionizing Radiations to bring it into line with the Royal Order of 23 December 1970, amending the general Regulations for Protection of the Population and Workers against the Hazards of Ionizing Radiations of 28 February 1963, subject to certain adaptations specific to military activities. (NEA)

  11. 75 FR 94 - Amendments to the Section 7216 Regulations-Disclosure or Use of Information by Preparers of Returns

    Science.gov (United States)

    2010-01-04

    ... Internal Revenue Service 26 CFR Part 301 RIN 1545-BI85 Amendments to the Section 7216 Regulations--Disclosure or Use of Information by Preparers of Returns AGENCY: Internal Revenue Service (IRS), Treasury... related to lists for solicitation of tax return business; the disclosure or use of...

  12. 78 FR 47215 - Petition to Amend Animal Welfare Act Regulations To Prohibit Public Contact With Big Cats, Bears...

    Science.gov (United States)

    2013-08-05

    ... Animal and Plant Health Inspection Service 9 CFR Parts 2 and 3 Petition to Amend Animal Welfare Act.... SUPPLEMENTARY INFORMATION: Background The Animal Welfare Act (AWA, 7 U.S.C. 2131 et seq.) authorizes the... Welfare Act regulations and standards, including to prohibit licensees from allowing individuals,...

  13. Indoor radon concentrations in ireland - effects and awareness of the 1997 amending building regulations

    International Nuclear Information System (INIS)

    Full text: In 2003, the Radiological Protection Institute of Ireland (R.P.I.I.) undertook the third of three localised radon surveys in Irish homes built since the introduction of the 1997 amending Building Regulations. Introduced in December 1997, these Regulations require that measures be taken at the construction stage to prevent the entry of radon into buildings from the underlying soil, and apply to buildings that commenced construction on or after the 1. July 1998. After Ennis (County Clare) in 2001 and Tralee (County Kerry) in 2002 (Synnott et al. 2004), the area selected in 2003 was the 10-km Irish National Grid Square containing Kilkenny City. As for the two previous surveys, this grid square is designated as a High Radon Area (where 10% or more of all houses are predicted to exceed 200 Bq/m3) and as such, all new homes which commenced construction after the introduction of the 1997 amending Building regulations are required to be fitted with a potential means to extract radon from the substructure (standby radon sump) and with an approved sealed membrane of low radon permeability over the footprint of the building (radon barrier). Between the three surveys, 247 homes were measured over a three-month period using Cr-39 passive alpha track detectors, 166 homes built since the amending Regulations came into force and 81 homes built in the immediate years prior to their introduction. Participating householders were also asked to complete a questionnaire to assess their awareness of the radon preventive measures included in their home at the time of construction. In all three surveys, the results indicate a clear a downward trend in the geometric mean between radon levels measured in new homes and in those built before 1998, between 30% and 50%. However, the results also highlight that the Building Regulations alone cannot guarantee that homes are adequately protected, as radon concentrations above the national Reference Level were found in homes built since

  14. Council Regulation (EC No. 1099/2009: state of the art and its application in a local health unit in Piedmont, Italy

    Directory of Open Access Journals (Sweden)

    Ginevra Paolucci

    2015-06-01

    Full Text Available In the last decade, the European Union has reinforced the concept of animal welfare throughout the food chain, from breeding to slaughtering. Studies and assessments of economic nature led to the adoption of Regulation EC 1099/2009 and at the end of 2014 this regulation will be applied to all the members involved in the food chain. For this reason several local health units organized different initiatives. The local health unit of Turin no. 4 (ASLTO4 has developed a project aimed to train food business operators (FBO to fulfill all the criteria developed in this Regulation. This initiative was divided into four steps: i communication to the companies about the criteria of the new regulation; ii a training course for official veterinarians; iii slaughterhouse audits in order to get information about animal welfare; iv and a training course for the personnel involved in slaughterhouses. The purpose of this paper was to report the results of the audits in order to identify critical points of structural, instrumental and documentary facilities. Then, the results can be compared with similar studies in order to develop common strategies and intervention areas.

  15. Reasoned opinion on the review of the existing maximum residue levels (MRLs for tritosulfuron according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2015-01-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance tritosulfuron. In order to assess the occurrence of tritosulfuron residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Some information required by the regulatory framework was found to be missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment is considered indicative only, some MRL proposals derived by EFSA still require further consideration by risk managers and measures for reduction of the consumer exposure should also be considered.

  16. Reasoned opinion on the review of the existing maximum residue levels (MRLs for flurtamone according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2012-12-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance flurtamone. In order to assess the occurrence of flurtamone residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. No information required by the regulatory framework was found to be missing and no risk to consumers was identified.

  17. Reasoned opinion on the review of the existing maximum residue levels (MRLs for thiabendazole according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-07-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance thiabendazole. In order to assess the occurrence of thiabendazole residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission as well as the import tolerances and European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and all MRL proposals derived by EFSA still require further consideration by risk managers.

  18. Reasoned opinion on the review of the existing maximum residue levels (MRLs for acibenzolar-S-methyl according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2013-02-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide acibenzolar-S-methyl. In order to assess the occurrence of acibenzolar-S-methyl residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the import tolerances and European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers.

  19. Reasoned opinion on the review of the existing maximum residue levels (MRLs for metsulfuron-methyl according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2013-01-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance metsulfuron-methyl. In order to assess the occurrence of metsulfuron-methyl residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC and European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers.

  20. Reasoned opinion on the review of the existing maximum residue levels (MRLs for mesosulfuron according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2012-11-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance mesosulfuron. In order to assess the occurrence of mesosulfuron residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. No information required by the regulatory framework was found to be missing and no risk to consumers was identified.

  1. Reasoned opinion on the review of the existing maximum residue levels (MRLs for fenamidone according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2012-11-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance fenamidone. In order to assess the occurrence of fenamidone residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers.

  2. Reasoned opinion on the review of the existing maximum residue levels (MRLs for benthiavalicarb according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2012-08-01

    Full Text Available

    According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance benthiavalicarb. In order to assess the occurrence of benthiavalicarb residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and one MRL proposal derived by EFSA still requires further consideration by risk managers.

  3. Reasoned opinion on the review of the existing maximum residue levels (MRLs for carfentrazone-ethyl according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2012-11-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance carfentrazone-ethyl. In order to assess the occurrence of carfentrazone-ethyl residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and all MRL proposals derived by EFSA still require further consideration by risk managers.

  4. Reasoned opinion on the review of the existing maximum residue levels (MRLs for kresoxim-methyl according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-01-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance kresoxim-methyl. In order to assess the occurrence of kresoxim-methyl residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission as well as the import tolerances and European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers.

  5. Reasoned opinion on the review of the existing maximum residue levels (MRLs for 1 methylcyclopropene according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-07-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance 1 methylcyclopropene. In order to assess the occurrence of 1 methylcyclopropene residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers.

  6. Container and waste pile standards for owners and operators of hazardous waste facilities: consolidated permit regulations--Environmental Protection Agency. Amendments to interim final rule.

    Science.gov (United States)

    1981-11-01

    The Environmental Protection Agency (EPA) is today promulgating amendments to the hazardous waste management regulations regarding the management of hazardous waste in containers and piles and associated permit regulations (40 CFR Part 264, Subparts I and L, and Part 122, Subpart B). These amendments better tailor the standards to the particular type of hazard posed by specific situations. The standards for containers are amended to waive the containment system requirements for wastes that do not contain free liquids, provided that the wastes are protected from contact with accumulated liquid. The standards for waste piles are amended to waive the containment system requirements for wastes that do not contain free liquids, provided that the pile is protected from precipitation by a structure and from surface water run-on and wind dispersal of the waste by the structure or some other means. The Agency believes these amendments believes these amendments will not reduce the level of protection of human health and the environment.

  7. The 'deep' independent system operator. A new sophisticated institutional design for system operators in the 3rd energy package of September 2007 in comparison to the Proposal of the 8 EC-Member States for a Directive of the EP and the Council amending Directive 2003/54/EC concerning common rules for the internal market in electricity and repealing Directive 96/92/EC. A German perspective on implementing an effective and efficient unbundling of Transmission System Operator

    International Nuclear Information System (INIS)

    The ownership unbundling-model and the 'deep' ISO-model (ISO stands for Independent System Operator) are not compatible with the EC-Treaty, if they were realized against the interest of the shareholder's assembly. The proposal of the eight EC member states for an effective and efficient unbundling avoids the constitutional problems and strengthens the independence of transmission system operators

  8. The Italian Helpdesk under the Regulation (EC No. 1272/2008 (CLP: three-year activity and experience (2009-2011

    Directory of Open Access Journals (Sweden)

    Sonia D'Ilio

    2012-01-01

    Full Text Available INTRODUCTION: The Regulation (EC No. 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP sets further obligations for manufacturers, importers, distributors, downstream users of substances either on their own or in mixtures. According to the European mandate, each Member State has constituted its National Helpdesk to provide advice to the interested parties on their duties under this Regulation. In Italy, the contact point for questions has been established at the National Centre for Chemical Substances of the Istituto Superiore di Sanità. FUNCTIONS: The responders of the Italian CLP Helpdesk process the requests that have been submitted by the dedicated website. Applicants are asked to complete the form with all the required information. The Helpdesk staff also take part in the European network of CLP, REACH and ECHA Helpdesks together with the European Commission and other parties, that is the HelpNet. RESULTS: The present paper describes the results of the three-year activity of the Italian CLP Helpdesk (2009-2011.

  9. 78 FR 6269 - Amendment to the International Traffic in Arms Regulations: Revision of U.S. Munitions List...

    Science.gov (United States)

    2013-01-30

    ...As part of the President's Export Control Reform effort, the Department of State proposes to amend the International Traffic in Arms Regulations (ITAR) to revise Category XVI (nuclear weapons related articles) of the U.S. Munitions List (USML). The revisions contained in this rule are part of the Department of State's retrospective plan under E.O. 13563 completed on August 17, 2011. The......

  10. Reasoned opinion on the review of the existing maximum residue levels (MRLs for captan according to Article 12 of Regulation (EC No 396/2005

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-04-01

    Full Text Available According to Article 12 of Regulation (EC No 396/2005, the European Food Safety Authority (EFSA has reviewed the Maximum Residue Levels (MRLs currently established at European level for the pesticide active substance captan. In order to assess the occurrence of captan residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC, the MRLs established by the Codex Alimentarius Commission as well as the European authorisations reported by Member States (incl. the supporting residues data. Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Some information required by the regulatory framework was found to be missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment is considered indicative only, some MRL proposals derived by EFSA still require further consideration by risk managers and measures for reduction of the consumer exposure should also be considered.

  11. Scientific Opinion on the substantiation of a health claim related to caffeine and increased alertness pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-02-01

    Full Text Available Following an application from SmithKline Beecham Limited, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to caffeine and increased alertness. The food constituent, caffeine, which is the subject of the health claim, is sufficiently characterised. Increased alertness might be a beneficial physiological effect. A claim on caffeine and increased alertness, in the general adult population, for products containing at least 75 mg of caffeine per serving, has already been assessed by the Panel with a favourable outcome. In the present application, the applicant proposed that, in order to bear the claim, a product should contain at least 40 mg of caffeine per serving. In weighing the evidence, the Panel took into account that most studies which measured reaction time in various cognitive tasks found no effect of caffeine at doses < 75 mg. In the particular dose range between 40 and < 75 mg, no effect of caffeine was found on the majority of outcome measures of reaction time. The Panel notes that the majority of studies with caffeine doses of 75 mg or higher showed a significant reduction in measures of reaction time. On the basis of the evidence provided, the Panel reiterates its previous conclusion that, in order to bear the claim, a product should contain at least 75 mg caffeine per serving. The Panel concludes that a cause and effect relationship has not been established between the consumption of caffeine and increased alertness under the conditions of use proposed by the applicant.

  12. 78 FR 39551 - Cotton Board Rules and Regulations: Adjusting Supplemental Assessment on Imports (2013 Amendment)

    Science.gov (United States)

    2013-07-02

    ... comments may be posted on the Internet and can be retrieved by most Internet search engines. Comments may... Register on December 10, 1991, (56 FR 64470). A proposed rule implementing the amended Order was published in the Federal Register on December 17, 1991, (56 FR 65450). Implementing rules were published...

  13. 78 FR 43972 - Amendments to the Export Administration Regulations: Implementation of Limited Syria Waiver for...

    Science.gov (United States)

    2013-07-23

    ...). See 69 FR 26766 (May 14, 2004). In addition, BIS later made administrative changes to General Order No.... See 74 FR 77115 (Dec. 12, 2011). On June 12, 2013, the Secretary of State exercised authority..., 2001 (3 CFR, 2001 Comp., p. 783 (2002)), as amended by Executive Order 13637 of March 8, 2013, 78...

  14. VALE: Determining the Need for Amended Regulation Regarding Free Movement of Companies within The EU

    DEFF Research Database (Denmark)

    Krarup, Mathias Dahlerup

    2013-01-01

    In its recent VALE-case the ECJ made it clear that Member States allowing national company conversions may not prohibit cross-border conversions. Thus, VALE complements the Cartesio-judgment by providing the right to move into a Member State. Recent Danish practice evidences the need for amended...

  15. 75 FR 63103 - Federal Travel Regulation (FTR); Lodging and Transportation Amendment

    Science.gov (United States)

    2010-10-14

    ..., contractors, or members of the public that require the approval of the Office of Management and Budget under... requirements of the Hotel and Motel Fire Safety Act of 1990 (the Act), as amended (see 5 U.S.C. 5707a). (c... hotels offer last standard room availability rates; (5) There are no early departure fees; and (6)...

  16. 76 FR 11701 - Amendments to Commodity Pool Operator and Commodity Trading Advisor Regulations Resulting From...

    Science.gov (United States)

    2011-03-03

    ... and Commodity Trading Advisors: Amendments to Compliance Obligations, 76 FR 7976 (Feb. 11, 2011); and Swap Data Recordkeeping and Reporting Requirements; Proposed Rule, 75 FR 76574 (Dec. 8, 2010). II. The... would establish business conduct standards for swap dealers and major swap participants. See 75 FR...

  17. 77 FR 19455 - Regulations Implementing the Byrd Amendments to the Black Lung Benefits Act: Determining Coal...

    Science.gov (United States)

    2012-03-30

    ... second sentence of Sec. 718.204(a) applies only to claims filed after January 19, 2001. See 68 FR 69930... presumptions). Congress added similar language to Section 422(l) to eliminate derivative entitlement for... ``Rebuttable Presumption,'' amended Section 411(c)(4) by deleting the section's last sentence--the...

  18. 77 FR 16670 - Amendment to the International Traffic in Arms Regulations: Sri Lanka

    Science.gov (United States)

    2012-03-22

    ... FR 4311; 3 CFR, 1977 Comp., p. 79; 22 U.S.C. 2651a; 22 U.S.C. 287c; E.O. 12918, 59 FR 28205; 3 CFR.... SUPPLEMENTARY INFORMATION: Section 126.1(n) is amended to implement section 7046(d) of Public Law 112-74, which..., the Department has reviewed the rule to ensure its consistency with the regulatory philosophy...

  19. Statement on a request from the European Commission related to the emergency measure notified by Bulgaria on genetically modified maize MON 810 according to Article 34 of Regulation (EC) 1829/2003

    OpenAIRE

    Arpaia, Salvatore; Birch, Andrew Nicholas Edmund; Chesson, Andrew; du Jardin, Patrick; Gathmann, Achim; Gropp, Jürgen; Herman, Lieve; Hoen-Sorteberg, Hilde-Gunn Opsahl; Jones, Huw; Kiss, József; Kleter, Gijs; Løvik, Martinus; Messéan, Antoine; Naegeli, Hanspeter; Nielsen, Kaare Magne

    2014-01-01

    Following a request of the European Commission, the European Food Safety Authority (EFSA) evaluated the concerns raised by Bulgaria and the accompanying documentation submitted under Article 34 of Regulation (EC) 1829/2003 in support of its request to prohibit the cultivation of the genetically modified maize MON 810 in the European Union. EFSA concludes that neither the arguments put forward by Bulgaria nor the documentation reveal new scientific evidence, in terms of risk to hum...

  20. Scientific Opinion on a request from the European Commission related to the emergency measure notified by Luxembourg on genetically modified maize MON 810 according to Article 34 of Regulation (EC) No 1829/2003

    OpenAIRE

    EFSA Panel on Genetically Modified Organisms (GMO)

    2013-01-01

    Following a request of the European Commission, the European Food Safety Authority’s Panel on Genetically Modified Organisms (EFSA GMO Panel) evaluated the documentation submitted by Luxembourg in support of its request for the prohibition of the placing on the market of the genetically modified maize MON 810 according to Article 34 of Regulation (EC) No 1829/2003. All concerns related to human and animal health or the environment raised by Luxembourg were already addressed in previous scient...

  1. Scientific Opinion on a request from the European Commission related to the emergency measure notified by Italy on genetically modified maize MON 810 according to Article 34 of Regulation (EC) No 1829/2003

    OpenAIRE

    EFSA Panel on Genetically Modified Organisms (GMO)

    2013-01-01

    Following a request of the European Commission, the European Food Safety Authority’s Panel on Genetically Modified Organisms (EFSA GMO Panel) evaluated the documentation submitted by Italy in support of its request for the prohibition of the placing on the market of the genetically modified maize MON 810 according to Article 34 of Regulation (EC) No 1829/2003. All concerns related to human and animal health or the environment raised by Italy were already addressed in previous scientific opini...

  2. Future perspectives on territorial cooperation in Europe [Electronic resource] : the EC regulation on a European grouping of territorial cooperation and the planned Council of Europe third protocol to the Madrid outline convention concerning euroregional co-operation groupings

    OpenAIRE

    Engl Alice

    2007-01-01

    The aim of this paper is to describe, analyze and compare the recent legal developments regarding territorial cooperation that can be observed on the international and supranational level in Europe: the EC Regulation on a European Grouping of Territorial Cooperation adopted in 2006, on the one hand, and the planned Third Protocol to the European Outline Convention on Transfrontier Co–operation between Territorial Communities and Authorities concerning Euroregional Co–operation Groupings of th...

  3. Trop-2表达下调对食管鳞癌EC9706细胞增殖和细胞迁移的影响%Down-regulation of Trop-2 expression inhibits cell proliferation and migration in human esophageal squamous cell carcinoma cell line EC9706

    Institute of Scientific and Technical Information of China (English)

    李慎柯; 范天黎; 寇洁; 崔瑶

    2011-01-01

    目的:研究肿瘤相关钙信号传导蛋白2(tumorassociated calcium signal transducer-2,Trop-2)表达下调对食管鳞癌EC9706细胞增殖和细胞迁移的影响,并探讨其可能的分子机制.方法:将Trop-2 siRNA和对照siRNA转染食管鳞癌EC9706细胞,利用实时荧光定量PCR和Western blotting检测转染Trop-2 siRNA后食管鳞癌EC9706细胞中Trop-2 mRNA和蛋白的表达.利用CCK-8试剂分析转染Trop-2 siRNA后EC9706细胞的增殖变化,接着采用Boyden小室研究下调Trop-2对EC9706细胞迁移的影响,最后利用Western blotting技术分析与细胞迁移相关基因MMP-7表达的变化.结果:转染Trop-2 48 h,Trop-2 siRNA组中Trop-2 mRNA和蛋白的表达显著低于未处理组和对照siRNA组(P<0.05).Trop-2表达下调能明显抑制食管鳞癌EC9706细胞的增殖(P<0.05).此外,Boyden小室结果表明,与未处理组(119.27±4.63)及对照siRNA组(112.81±5.01)相比,Trop-2 siRNA组中EC9706细胞的穿膜数(65.29±4.33)明显降低.Westernblotting结果表明,Trop-2 siRNA能明显降低食管鳞癌EC9706细胞中MMP-7的表达.结论:Trop-2表达下调能抑制食管鳞癌细胞的增殖和迁移,其介导的迁移能力的降低可能与MMP-7表达的下调密切相关,操纵Trop-2有望成为食管鳞癌的分子治疗靶点.%AIM: To investigate the effect of down-regulation of tumor-associated calcium signal trans-ducer-2 (Trop-2) expression on cell proliferation and migration in human esophageal squamous cell carcinoma (ESCC cell line EC9706 and to explore possible molecular mechanisms involved.METHODS: Trop-2-specific small interferingRNA (siRNA) and control siRNA were transfect-ed into EC9706 cells, and expression of Trop-2 mRNA and protein was detected by real-time PCR and Western blotting. CCK-8 assay was used to measure cell proliferation, and Boyden chamber assay was utilized to determine cell migration. The expression of cell migration-related MMP-7 protein was detected by Western blotting

  4. Some issues on the Law for the Regulations of Nuclear Source Material, Nuclear Fuel Material and Reactors Amendment after JCO criticality accident

    International Nuclear Information System (INIS)

    As the Amendment of the Law for the Regulation of Nuclear Material, Nuclear Fuel Material and Reactors on an opportunity of the JCO criticality accident can be almost evaluated at a viewpoint of upgrading on effectiveness of safety regulation, it is thought to remain a large problem to rely on only enforcement of regulation due to amendment of the Law at future accident. In future, it can be also said to be important subjects to further expand a philosophy on the regulation (material regulation) focussed to hazards of nuclear material itself, not only to secure effectiveness on the multi-complementary safety regulation due to the administrative agency and the Nuclear Safety Commission but also to prepare a mechanism reflexible of a new information to the safety regulation, and to prepare a mechanism to assist adequate business execution and so forth of enterprises. (G.K.)

  5. E. coli histidine triad nucleotide binding protein 1 (ecHinT is a catalytic regulator of D-alanine dehydrogenase (DadA activity in vivo.

    Directory of Open Access Journals (Sweden)

    Sanaa Bardaweel

    Full Text Available Histidine triad nucleotide binding proteins (Hints are highly conserved members of the histidine triad (HIT protein superfamily. Hints comprise the most ancient branch of this superfamily and can be found in Archaea, Bacteria, and Eukaryota. Prokaryotic genomes, including a wide diversity of both gram-negative and gram-positive bacteria, typically have one Hint gene encoded by hinT (ycfF in E. coli. Despite their ubiquity, the foundational reason for the wide-spread conservation of Hints across all kingdoms of life remains a mystery. In this study, we used a combination of phenotypic screening and complementation analyses with wild-type and hinT knock-out Escherichia coli strains to show that catalytically active ecHinT is required in E. coli for growth on D-alanine as a sole carbon source. We demonstrate that the expression of catalytically active ecHinT is essential for the activity of the enzyme D-alanine dehydrogenase (DadA (equivalent to D-amino acid oxidase in eukaryotes, a necessary component of the D-alanine catabolic pathway. Site-directed mutagenesis studies revealed that catalytically active C-terminal mutants of ecHinT are unable to activate DadA activity. In addition, we have designed and synthesized the first cell-permeable inhibitor of ecHinT and demonstrated that the wild-type E. coli treated with the inhibitor exhibited the same phenotype observed for the hinT knock-out strain. These results reveal that the catalytic activity and structure of ecHinT is essential for DadA function and therefore alanine metabolism in E. coli. Moreover, they provide the first biochemical evidence linking the catalytic activity of this ubiquitous protein to the biological function of Hints in Escherichia coli.

  6. Owners responsibility of refrigeration equipment according F-Gas-regulation 'EC 842/2006' and answers; Betreiberpflichten nach 'F-Gas-Verordnung' EG 842/2006 und Antworten darauf

    Energy Technology Data Exchange (ETDEWEB)

    Beermann, Karsten [IKKE gGmbH, Duisburg (Germany)

    2012-08-15

    The results of the F-Gas-regulation EC 842/2006 are some responsibilities for owners of refrigeration equipment. To fulfill these duties exist e-learning training modules and different tools which are the result of a European LEONARDO- project. Particularly the awareness of the equipment owner and the certified person (refrigeration technician) according the regulation will be the main background of a safe handling of refrigerants for an effective environmental protection. Interested persons and companies will find helpful information to learn good practice. (orig.)

  7. EVALUATION OF THE FIRST YEAR OF APPLICATION OF THREE-YEAR REGIONAL INTEGRATED PLAN OF CONTROLS (2008/2010 IN LAZIO REGION (REGULATION EC 882/2004

    Directory of Open Access Journals (Sweden)

    S. Saccares

    2011-01-01

    Full Text Available The evaluation of the first year of the three-year Regional Integrated Plan of Controls has highlighted some problems that does not allow, in some cases, to perform risk assessments to different production processes. Evidence of these concerns has allowed to analyze the corrective actions to be applied in order to make the plan appropiate for the purposes intended by the EC.

  8. 75 FR 16351 - Medical Devices; Technical Amendment

    Science.gov (United States)

    2010-04-01

    ..., and 1050 Medical Devices; Technical Amendment AGENCY: Food and Drug Administration, HHS. ACTION: Final rule; technical amendment. SUMMARY: The Food and Drug Administration (FDA) is amending certain medical device regulations to correct statutory and regulatory references to ensure accuracy, consistency,...

  9. Programming Amazon EC2

    CERN Document Server

    Vliet, Jurg

    2011-01-01

    If you plan to use Amazon Web Services to run applications in the cloud, the end-to-end approach in this book will save you needless trial and error. You'll find practical guidelines for designing and building applications with Amazon Elastic Compute Cloud (EC2) and a host of supporting AWS tools, with a focus on critical issues such as load balancing, monitoring, and automation. How do you move an existing application to AWS, or design your application so that it scales effectively? How much storage will you require? Programming Amazon EC2 not only helps you get started, it will also keep y

  10. Scientific Opinion on the substantiation of a health claim related to Rosbacher drive® and increased attention pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)

    2014-01-01

    Following an application from Hassia Mineralquellen GmbH & Co KG, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to Rosbacher drive® and increased attention. The Panel considers that Rosbacher drive®, which contains natural mineral water plus...

  11. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to iron and maintenance of normal hair growth pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    of a health claim based on newly developed scientific evidence related to iron and maintenance of normal hair growth. Iron is sufficiently characterised. The claimed effect is “reduction of excessive hair loss”. The target population proposed by the applicant is non-menopausal women, aged between 19 and 49......Following an application from Pierre Fabre Dermo-Cosmétique, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation...

  12. Scientific Opinion on the substantiation of a health claim related to FRUIT UP® and a reduction of post-prandial blood glucose responses pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2015-01-01

    Following an application from WILD-Valencia SAU, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Spain, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to FRUIT UP® and a reduction of post-prandial blood glucose responses. The Panel considers that the food, FRUIT UP®, and the food (i.e. glucose, suc...

  13. Scientific Opinion on the substantiation of a health claim related to “native chicory inulin” and maintenance of normal defecation by increasing stool frequency pursuant to Article 13.5 of Regulation (EC) No 1924/2006

    OpenAIRE

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)

    2015-01-01

    Following an application from BENEO-Orafti S.A., submitted pursuant to Article 13.5 of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to “native chicory inulin” and maintenance of normal defecation by increasing stool frequency. The food constituent that is a subject of a claim is “native chicory inulin”. The Panel consi...

  14. . boulardii CNCM I-1079 and defence against pathogenic gastro-intestinal microorganisms (ID 3017, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to provide a scientific opinion on a health claim pursuant to Article 13 of Regulation (EC) No 1924/2006 in the framework of further assessment related to a combination......, is a beneficial physiological effect. The proposed target population is the general population. No human intervention studies which investigated the effect of a combination of L. rhamnosus CNCM I-1720, L. helveticus CNCM I-1722, B. longum subsp. longum CNCM I-3470 and S. cerevisiae var. boulardii CNCM I-1079 were...

  15. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucosamine and maintenance of normal joint cartilage pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Merck Consumer Healthcare, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health...... to studies in patients with osteoarthritis, in healthy subjects, in animals and in vitro as being pertinent to the health claim. In weighing the evidence, the Panel took into account that no human studies were provided from which conclusions could be drawn on the effect of dietary glucosamine...

  16. 76 FR 20901 - Further Amendments to General Regulations of the Food and Drug Administration To Incorporate...

    Science.gov (United States)

    2011-04-14

    ... appropriate, in light of FDA's authority to regulate these products under the Family Smoking Prevention and...; or aterial with respect to consequences which may result from use of the article under: The... November 12, 2010 (75 FR 69524). B. Section 1.101--Notification and Recordkeeping Section 1.101...

  17. 77 FR 5171 - Further Amendments to General Regulations of the Food and Drug Administration to Incorporate...

    Science.gov (United States)

    2012-02-02

    ... light of FDA's authority to regulate these products under the Family Smoking Prevention and Tobacco... INFORMATION: I. Background In the Federal Register of April 14, 2011 (76 FR 20901), FDA issued a proposed rule...; or aterial with respect to consequences which may result from use of the article under:...

  18. 78 FR 52680 - Amendment to the International Traffic in Arms Regulations: Registration and Licensing of Brokers...

    Science.gov (United States)

    2013-08-26

    ... licensing regime and to effect export compliance/ enforcement activities. (ii) The Office of Defense Trade... Regulations: Registration and Licensing of Brokers, Brokering Activities, and Related Provisions AGENCY... technical changes are made to other parts of the ITAR that affect export as well as brokering...

  19. Scientific Opinion on a request from the European Commission related to the emergency measure notified by Luxembourg on genetically modified maize MON 810 according to Article 34 of Regulation (EC No 1829/2003

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Genetically Modified Organisms (GMO

    2013-09-01

    Full Text Available Following a request of the European Commission, the European Food Safety Authority’s Panel on Genetically Modified Organisms (EFSA GMO Panel evaluated the documentation submitted by Luxembourg in support of its request for the prohibition of the placing on the market of the genetically modified maize MON 810 according to Article 34 of Regulation (EC No 1829/2003. All concerns related to human and animal health or the environment raised by Luxembourg were already addressed in previous scientific opinions of the EFSA GMO Panel on maize MON 810 while other concerns relate to socio-economic aspects and co-existence and thus fall outside the remit of EFSA. Therefore, the EFSA GMO Panel concludes that, based on the documentation submitted by Luxembourg, there is no specific scientific evidence, in terms of risk to human and animal health or the environment, that would support the notification of an emergency measure under Article 34 of Regulation (EC No 1829/2003 and that would invalidate its previous risk assessments of maize MON 810.

  20. Use of the EFSA Standard Sample Description (SSD for the reporting of data on the control of pesticide residues in food and feed according to Regulation (EC No 396/2005 (Version: 2013 Data Collection

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2014-01-01

    Full Text Available Regulation (EC No 396/2005 on Maximum Residue Levels of pesticides in or on food and feed of plant and animal origin requires the Member States to monitor pesticide residue levels in food commodities and submit the monitoring results to EFSA and the European Commission. In 2009, EFSA developed the Standard Sample Description (SSD, which is a standardised model for the reporting of harmonised data on analytical measurements of chemical substances occurring in food, feed and water. This document is intended to provide the Member States with specific guidance on how to use the SSD for the reporting of the national results of the pesticide monitoring in the framework of Article 32 of Regulation (EC No 396/2005. In particular, this document is meant to provide SSD users with support in selecting the appropriate codes for the elements which pertain to pesticide residues monitoring data. This document shall complement the EFSA guidance document “Standard sample description for food and feed”.

  1. Scientific Opinion on a request from the European Commission related to the emergency measure notified by Italy on genetically modified maize MON 810 according to Article 34 of Regulation (EC No 1829/2003

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Genetically Modified Organisms (GMO

    2013-09-01

    Full Text Available Following a request of the European Commission, the European Food Safety Authority’s Panel on Genetically Modified Organisms (EFSA GMO Panel evaluated the documentation submitted by Italy in support of its request for the prohibition of the placing on the market of the genetically modified maize MON 810 according to Article 34 of Regulation (EC No 1829/2003. All concerns related to human and animal health or the environment raised by Italy were already addressed in previous scientific opinions of the EFSA GMO Panel on maize MON 810 while other concerns relate to co-existence and thus fall outside the remit of EFSA. Therefore, the EFSA GMO Panel concludes that, based on the documentation submitted by Italy, there is no specific scientific evidence, in terms of risk to human and animal health or the environment, that would support the notification of an emergency measure under Article 34 of Regulation (EC No 1829/2003 and that would invalidate its previous risk assessments of maize MON 810.

  2. 76 FR 10291 - Amendment to the International Traffic in Arms Regulations: Electronic Payment of Registration...

    Science.gov (United States)

    2011-02-24

    .... Payment methods (i.e., ACH and SWIFT) are dependent on the source of the funds (U.S. or foreign bank... Regulations (ITAR) to change the method of payment to electronic submission of registration fees. Definitions..., 90 Stat. 744 (22 U.S.C. 2752, 2778, 2797); 22 U.S.C. 2794; E.O. 11958, 42 FR 4311; E.O. 13284, 68...

  3. New Amendments Introduced to European Union Competition Law Due to the Expiration of Block Exemption Regulations Conference at Łazarski University. Report

    OpenAIRE

    Kozak, Małgorzata

    2011-01-01

    On 7 June 2010, a conference under the title New Amendments Introduced to European Union Competition Law Due to the Expiration of Block Exemption Regulations took place at the Lazarski University in Warsaw. The conference was opened by Professor Zbigniew Lasocik, the Dean of the Law Faculty of the Lazarski University, who started his speech by introducing the University and emphasizing the Faculty of Law’s aim to ensure high quality legal education.

  4. Scientific Opinion on the substantiation of a health claim related to glycaemic carbohydrates and contribution to normal cognitive function pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    cognition. The Panel concludes that a cause and effect relationship has been established between the consumption of glycaemic carbohydrates and contribution to normal cognitive function. A daily intake of 130 g of glycaemic carbohydrates has been estimated to cover the glucose requirement of the brain......Following an application from Dextro Energy GmbH & Co. KG, submitted for the authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...... an opinion on the scientific substantiation of a health claim related to glycaemic carbohydrates and contribution to normal cognitive function. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The Panel considers that the food constituent...

  5. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific opinion on the safety of 2'-O-fucosyllactose as a novel food ingredient pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on 2'-O-fucosyllactose as a novel food ingredient (NFI) submitted pursuant to Regulation (EC) No 258/97 of the European Parliament and of the Council...... added to follow-on and young-child formulae, at concentrations up to 1.2 g/L of 2’-FL (alone or in combination with LNnT, at concentrations up to 0.6 g/L, at a ratio of 2:1). The Panel also concludes that 2’-FL is safe when added to other foods at the uses and use levels proposed by the applicant....

  6. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific opinion on the Safety of lacto-N-neotetraose as a novel food ingredient pursuant to Regulation (EC) No 258/97

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on lacto-N-neotetraose as a novel food ingredient (NFI) submitted pursuant to Regulation (EC) No 258/97 of the European Parliament and of the Council...... added to follow-on and young-child formulae, at concentrations up to 0.6 g/L of LNnT (alone or in combination with 2’-FL, at concentrations up to 1.2 g/L, at a ratio of 1:2). The Panel also concludes that LNnT is safe when added to other foods at the uses and use levels proposed by the applicant....

  7. Scientific Opinion on the substantiation of a health claim related to hyaluronic acid and protection of the skin against dehydration pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-07-01

    Full Text Available

    Following an application from Nutrilinks Sarl, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to hyaluronic acid and protection of the skin against dehydration. The food constituent that is the subject of the health claim, hyaluronic acid, is sufficiently characterised. The claimed effect, protection of the skin against dehydration, is a beneficial physiological effect. The target population proposed by the applicant is the general population. No human studies have been provided from which conclusions could be drawn for the scientific substantiation of the claim. A cause and effect relationship has not been established between the consumption of hyaluronic acid and protection of the skin against dehydration.

  8. Scientific Opinion on the substantiation of a health claim related to FRUIT UP® and a reduction of post-prandial blood glucose responses pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    on the scientific substantiation of a health claim related to FRUIT UP® and a reduction of post-prandial blood glucose responses. The Panel considers that the food, FRUIT UP®, and the food (i.e. glucose, sucrose) that FRUIT UP® should replace in foods or beverages are both sufficiently characterised in relation......Following an application from WILD-Valencia SAU, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Spain, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...... could be drawn, FRUIT UP® decreased post-prandial blood glucose responses compared with glucose but not compared with sucrose, and that this effect may be explained by the partial replacement of glucose by fructose. The Panel concludes that a cause and effect relationship has not been established...

  9. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucosamine and maintenance of joints pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    claim based on newly developed scientific evidence related to glucosamine and maintenance of joints. The food constituent that is the subject of the health claim is glucosamine, which is sufficiently characterised. The claimed effect is “contributes to the protection of joint cartilage exposed......Following an application from Béres Pharmaceuticals Ltd., submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Hungary, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health...... periods of three months can predict net changes in collagen type II in joint cartilage. The Panel concludes that a cause and effect relationship has not been established between the consumption of glucosamine and maintenance of joints. © European Food Safety Authority, 2011...

  10. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014 . Scientific Opinion on the substantiation of a health claim related to zinc and normal growth pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    substantiation of a health claim related to zinc and normal growth. The food constituent, zinc, which is the subject of the health claim, is sufficiently characterised. Normal growth is a beneficial physiological effect for infants and young children. The Panel considers that the role of zinc in normal growth......Following an application from Specialised Nutrition Europe (formerly IDACE), submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...... is well established. Growth retardation is one of the clinical manifestations of severe zinc deficiency. Zinc supplementation has been reported to stimulate growth and development in zinc-deficient infants and young children. The Panel concludes that a cause and effect relationship has been established...

  11. Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to sugar beet fibre and decreasing intestinal transit time pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    based on newly developed scientific evidence related to sugar beet fibre and “decreasing intestinal transit time”. The food constituent that is the subject of the health claim is sugar beet fibre. This opinion applies to sugar beet fibre naturally present in foods and to those forms added to foods......Following an application from Nordic Sugar A/S, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Denmark, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim...... that decreasing intestinal (orofaecal) transit time may be a beneficial physiological effect. The applicant provided four human studies as pertinent to the health claim. The Panel considers that no conclusion can be drawn from three studies for the scientific substantiation of the claim owing to methodological...

  12. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to beta-palmitate and increased calcium absorption pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    -palmitate and increased calcium absorption. The scope of the application was proposed to fall under a health claim referring to children’s development and health. The food constituent that is the subject of the health claim is beta-palmitate, a structured triglyceride with a high content of palmitic acid at the sn-2......Following an application from IDACE, submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to beta......, including healthy infants consuming follow-on formula, preterm infants and infants needing foods for particular nutritional uses including foods for special medical purposes. The Panel considers that an increase in calcium absorption might be a beneficial physiological effect. In weighing the evidence...

  13. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to sugar beet fibre and increasing faecal bulk pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    based on newly developed scientific evidence related to sugar beet fibre and “increasing faecal bulk”. The food constituent that is the subject of the health claim is sugar beet fibre. The Panel considers that sugar beet fibre is sufficiently characterised in relation to the claimed effect. The claimed......Following an application from Nordic Sugar A/S, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Denmark, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim...... that a cause and effect relationship has been established between the consumption of sugar beet fibre and increasing faecal bulk. The following wording reflects the scientific evidence: “Sugar beet fibre increases faecal bulk”. In order to bear the claim a food should be at least “high in fibre” as per...

  14. Scientific Opinion on the substantiation of a health claim related to ♀EFAX™ and reduction of menstrual discomfort pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2013-02-01

    Full Text Available Following an application from Nutrilinks Sarl submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Cyprus, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to ♀EFAX™ and reduction of menstrual discomfort. The food, ♀EFAX™, which is standardised pure krill oil and is the subject of the health claim, is sufficiently characterised. The claimed effect, reduction of menstrual discomfort, is a beneficial physiological effect. No human intervention studies from which conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. A cause and effect relationship has not been established between the consumption of ♀EFAX™ and reduction of menstrual discomfort.

  15. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to phaseolamine and reduction in body weight (ID 1701) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to phaseolamine and reduction in body weight. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders. The food...... assumes that the claimed effect refers to a reduction in body weight. The Panel considers that reduction in body weight is a beneficial physiological effect. In weighing the evidence, the Panel took into account that although one short-term (30 day) intervention study in humans showed an effect...

  16. Proposed amendments to the Staff Rules & Regulations related to exceptional contract extension beyond the statutory retirement age for members of the personnel appointed by the Council pursuant to Article S II 1.01

    CERN Document Server

    2011-01-01

    Proposed amendments to the Staff Rules & Regulations related to exceptional contract extension beyond the statutory retirement age for members of the personnel appointed by the Council pursuant to Article S II 1.01

  17. Proposed amendments to the Staff Rules and Regulations related to exceptional contract extension beyond the statutory retirement age for members of the personnel appointed by the Council pursuant to article S II 1.01

    CERN Document Server

    2011-01-01

    Proposed amendments to the Staff Rules and Regulations related to exceptional contract extension beyond the statutory retirement age for members of the personnel appointed by the Council pursuant to article S II 1.01

  18. 77 FR 33635 - Amendment to the Bank Secrecy Act Regulations-Requirement That Clerks of Court Report Certain...

    Science.gov (United States)

    2012-06-07

    ...CEN is authorized to impose anti-money laundering (``AML'') program requirements on financial...\\ 66 FR 67680 (December 31, 2001), codified at 31 CFR 1010.330. \\7\\ 26 CFR 1.6050I-1. As amended... Code); (iii) Money laundering (as defined in section 1956 or 1957 of title 18 of the United States...

  19. 77 FR 5387 - Amendment to the Export Administration Regulations: Addition of a Reference to a Provision of the...

    Science.gov (United States)

    2012-02-03

    ... Iran Sanctions Act of 1996 (ISA), which states BIS's licensing policy for export and reexport... Bureau of Industry and Security 15 CFR Part 744 RIN 0694-AF30 Amendment to the Export Administration... the Licensing Policy for Transactions Involving Persons Sanctioned Under the ISA AGENCY: Bureau...

  20. Scientific Opinion on the substantiation of a health claim related to Rosbacher drive® and increased attention pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-02-01

    Full Text Available Following an application from Hassia Mineralquellen GmbH & Co KG, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to Rosbacher drive® and increased attention. The Panel considers that Rosbacher drive®, which contains natural mineral water plus grape juice, lemon juice, pomegranate juice, elderberry juice, isomaltulose, sucrose, fructose syrup, caffeine, ascorbic acid and natural flavourings, is sufficiently characterised. The claimed effect, increased attention, is a beneficial physiological effect. The single study which was carried out with Rosbacher drive® was an open-label, non-randomised sequential study and the study did not report on any outcomes of attention. No conclusions can be drawn from this study for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of Rosbacher drive® and increased attention.

  1. Scientific Opinion on the substantiation of a health claim related to barley soup “Orzotto” and protection of blood lipids from oxidative damage pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-01-01

    Full Text Available Following an application from Italsur srl, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Italy, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to barley soup “Orzotto” and protection of blood lipids from oxidative damage. The Panel considers that barley soup “Orzotto”, which is a vegetable mix containing pearled barley, Tuscan Black cabbage, potatoes, “blu savoy” cabbage, purple carrots, “bi coloured” spinach, “tri-coloured” Swiss chard, onions, red and yellow celery and parsley, is sufficiently characterised. The claimed effect, protection of blood lipids from oxidative damage, may be a beneficial physiological effect. No human intervention studies from which conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between the consumption of barley soup “Orzotto” and protection of blood lipids from oxidative damage.

  2. Scientific Opinion on the substantiation of a health claim related to beta-alanine and increase in physical performance during short-duration, high-intensity exercise pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-07-01

    Full Text Available Following an application from Natural Alternative International, Inc. (NAI, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to beta-alanine and increase in physical performance during short-duration, high-intensity exercise. The food constituent that is the subject of the claim is beta-alanine, which is sufficiently characterised. The Panel considers that an increase in physical performance during short-duration, high-intensity exercise is a beneficial physiological effect. In weighing the evidence the Panel took into account that only one out of 11 pertinent human intervention studies (including 14 pertinent outcomes from which conclusions could be drawn showed an effect of beta-alanine on physical performance during short-duration, high intensity exercise. The Panel concludes that a cause and effect relationship has not been established between the consumption of beta-alanine and an increase in physical performance during short-duration, high intensity exercise.

  3. Scientific Opinion on the substantiation of a health claim related to KF2BL20 and maintenance of normal hair pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-07-01

    Full Text Available

    Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to KF2BL20, which is a combination of keratin, copper, zinc, niacin, pantothenic acid, pyridoxine and D-biotin, and maintenance of normal hair. The Panel considers that KF2BL20 is sufficiently characterised. The claimed effect is “helps to reinforce hair strength and normal hair function and contributes to reduce hair loss”. The target population proposed by the applicant is healthy adults in the general population. The Panel considers that maintenance of normal hair is a beneficial physiological effect. The applicant identified one single arm study as being pertinent to the health claim. The Panel notes that this study was uncontrolled and considers that no conclusions can be drawn from this study for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of KF2BL20 and maintenance of normal hair.

  4. Scientific Opinion on the substantiation of a health claim related to iodine and contribution to normal cognitive development pursuant to Article 14 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-01-01

    Full Text Available Following an application from Specialised Nutrition Europe (formerly IDACE, submitted pursuant to Article 14 of Regulation (EC No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to iodine and contribution to normal cognitive development. The food constituent, iodine, which is the subject of the health claim, is sufficiently characterised. Contribution to normal cognitive development is a beneficial physiological effect for infants and young children. A claim on iodine and contribution to normal cognitive and neurological function in the general population has already been assessed with a favourable outcome. In addition, there is a large body of evidence indicating a crucial role for iodine in growth and development. The Panel notes the well established role of iodine in preventing iodine deficiency disorders such as retarded mental and physical development in children and adolescents, and impaired mental function and reduced cognitive capacity for people of all ages. The Panel concludes that a cause and effect relationship has been established between the dietary intake of iodine and contribution to normal cognitive development.

  5. Scientific Opinion on the substantiation of a health claim related to OptiEFAX™ and maintenance of normal blood concentrations of triglycerides pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-07-01

    Full Text Available

    Following an application from Nutrilinks Sarl, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to OptiEFAX™ and maintenance of normal blood concentrations of triglycerides. The food that is the subject of the health claim, OptiEFAX™, which is standardised pure krill oil, is sufficiently characterised in relation to the claimed effect. The claimed effect, maintenance of normal blood concentrations of triglycerides, is a beneficial physiological effect. The target population proposed by the applicant is the general population. No human studies have been provided from which conclusions could be drawn for the scientific substantiation of the claim. A cause and effect relationship has not been established between the consumption of OptiEFAX™ and maintenance of normal blood concentrations of triglycerides.

  6. Scientific Opinion on the substantiation of a health claim related to krill oil and maintenance of joint comfort pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-12-01

    Full Text Available Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to krill oil and maintenance of joint comfort. The Panel considers that krill oil is sufficiently characterised. The claimed effect proposed by the applicant is “helps to improve the comfort of sensitive joints”. The Panel considers that maintenance of joint comfort is a beneficial physiological effect. The applicant identified one human intervention study as being pertinent to the health claim. The Panel notes that chronic inflammation was an inclusion criterion of the study, that a significant number of the patients recruited were reported to have confirmed diagnosis of osteoarthritis, rheumatoid arthritis, or of both cardiovascular disease and osteoarthritis, and that the WOMAC osteoarthritis questionnaire was administered only to patients with arthritic disease (osteoarthritis or rheumatoid arthritis. The Panel also notes that no evidence which could justify the extrapolation of the results, obtained in patients with joint diseases characterised by chronic inflammation, to the target population, subjects without chronic joint diseases, was provided by the applicant. The Panel considers that no conclusions can be drawn from this study for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of krill oil and maintenance of joint comfort.

  7. Scientific Opinion on the substantiation of a health claim related to Bimuno® GOS and reducing gastro-intestinal discomfort pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2013-06-01

    Full Text Available Following an application from Clasado Limited, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Malta, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to Bimuno® GOS and reducing gastro-intestinal discomfort. The food constituent, Bimuno® GOS, a mixture of β-galacto-oligosaccharides, which is the subject of the health claim, is sufficiently characterised. The claimed effect proposed by the applicant is “reduce bloating, flatulence and abdominal pain. These effects can be described collectively as abdominal discomfort” and the target population proposed by the applicant is the general adult population. Reducing gastro-intestinal discomfort is a beneficial physiological effect. A health claim on Bimuno® GOS and reducing gastro-intestinal discomfort has already been assessed by the Panel with an unfavourable outcome. The supplementary information submitted by the applicant in this application did not provide evidence that could be used for the scientific substantiation of this claim.

  8. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to Saccharomyces boulardii ATY-SB-101 (BCCM/MUCL 53837) (ID 1010, 1011, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on health claims pursuant to Article 13.1 of Regulation (EC) No 1924/2006 in the framework of further assessment related to Saccharomyces boulardii A...

  9. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to a combination of lycopene, vitamin E, lutein and selenium and “ helps to prepare and activate tannin g ” pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Cyprus, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health clai...

  10. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to “non - fermentable ” carbohydrates and maintenance of tooth mineralisation by decreasing tooth demineralisation pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Roquette Frères, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the s...

  11. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to a combination of lutein and zeaxanthin and improved vision under bright light conditions pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to a combination of lutein and zeaxanthin and improved vision under bright light conditions pursuant to Article 13(5) of Regulation (EC) No 1924/2006....

  12. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014 . Scientific Opinion on the substantiation of a health claim related to selenium and protection of DNA, proteins a nd lipids from oxidative damage pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to ...

  13. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014 . Scientific Opinion on the substantiation of a health claim related to zinc and normal function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...

  14. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to olive leaf (Olea europaea L.) water extract and increase in glucose tolerance pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Comvita New Zealand Limited, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...

  15. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to Bimuno® GOS and reducing gastro-intestinal discomfort pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Clasado Limited, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Malta, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  16. Scientific Opinion on the substantiation of a health claim related to Teestar™, a fenugreek seed extract standardised by its content of galactomannan, and a reduction of post-prandial glycaemic responses pursuant to Article 13(5) of Regulation (EC) No

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Avesthagen Limited, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...

  17. Conforming Amendments to the Regulations Governing Nondiscrimination on the Basis of Race, Color, National, Origin, Disability, Sex, and Age under the Civil Rights Restoration Act of 1987; Final Rule. Federal Register, Part IV: Department of Education, 34 CFR Parts 100, 104, 106, and 110.

    Science.gov (United States)

    Federal Register, 2000

    2000-01-01

    The Secretary amends the regulations governing nondiscrimination on the basis of race, color, national origin, sex, handicap, and age to conform with statutory amendments made by the Civil Rights Restoration Act of 1987 (CRRA). These amendments add a definition of "program or activity" or "program" that adopts the statutory definition of "program…

  18. 78 FR 23171 - Amendments to the 2013 Escrows Final Rule Under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-04-18

    ... Settlement Procedures Act (Regulation X) (2013 HOEPA Final Rule), 78 FR 6855; Disclosure and Delivery... (Regulation B), 78 FR 7215; Mortgage Servicing Rules Under the Real Estate Settlement Procedures Act (Regulation X), 78 FR 10695; Mortgage Servicing Rules Under the Truth in Lending Act (Regulation Z), 78...

  19. Mechanisms of soil pH regulation by biochar amendments and consequences for biochar long-term effects

    OpenAIRE

    Rees, Frédéric; Morel, Jean-Louis

    2015-01-01

    Soil amendments of biochar, i.e. the solid product of biomass pyrolysis, have been increasingly investigated over the last few years as a way to store stable C in soils, to improve crop production and to remediate degraded and contaminated land. Many short-term effects of biochar on soil chemical and biological properties may be explained by the observed increase of soil pH, largely reported in the recent scientific literature for acid or neutral soils. However, both the mechanisms by which b...

  20. 7 CFR 1.165 - Amendments.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Amendments. 1.165 Section 1.165 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Rules of Practice Governing Cease and Desist Proceedings Under Section 2 of the Capper-Volstead Act § 1.165 Amendments. Amendments to the complaint may...

  1. Regulator process for the authorization of an amendment to the operation license of a nuclear power plant in Mexico; Proceso regulador para la autorizacion de una enmienda a la licencia de operacion de una central nuclear en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Perez, R.; Espinosa V, J.M.; Salgado, J.R.; Mamani, Y.R. [CNSNS, Dr. Barragan 779, Col. Narvarte, 03020 Mexico D.F. (Mexico)

    2005-07-01

    The regulator process by which an authorization is granted from an amendment to the License of Operation of a nuclear power station in Mexico is described. It makes an appointment the effective legal mark, the technical characteristics of the modification, the evaluation process and deposition upon oath of tests and finally the elaboration of the Safety report and the Technical Verdict that is a correspondent for the regulator organism to the Secretary of Energy, the one that in turn is the responsible of granting the amendment the License just as it establishes it the Law. (Author)

  2. Scientific Opinion on the substantiation of a health claim related to ?native chicory inulin? and maintenance of normal defecation by increasing stool frequency pursuant to Article 13.5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2015-01-01

    Full Text Available Following an application from BENEO-Orafti S.A., submitted pursuant to Article 13.5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to “native chicory inulin” and maintenance of normal defecation by increasing stool frequency. The food constituent that is a subject of a claim is “native chicory inulin”. The Panel considers that “native chicory inulin”, a non-fractionated mixture of monosaccharides (< 10%, disaccharides, inulin-type fructans and inulin extracted from chicory, with a mean DP ≥ 9, is sufficiently characterised in relation to the claimed effect. The Panel considers that maintenance of normal defecation by increasing stool frequency (provided that it does not result in diarrhoea is a beneficial physiological effect. Six studies involving 86 subjects consistently showed that consumption of “native chicory inulin” at an amount of at least 12 g/day increases stool frequency. The Panel also notes the plausible mechanisms by which inulin and inulin-type fructans in “native chicory inulin” could exert the claimed effect. The Panel concludes that a cause and effect relationship has been established between the consumption of “native chicory inulin” and maintenance of normal defecation by increasing stool frequency. The following wording reflects the scientific evidence: “Chicory inulin contributes to maintenance of normal defecation by increasing stool frequency”. In order to obtain the claimed effect, 12 g of “native chicory inulin” should be consumed daily.

  3. Scientific Opinion on the substantiation of a health claim related to OXY 280 and reduction of body weight pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-12-01

    Full Text Available Following an application from Actina, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to OXY 280 and reduction of body weight. The food constituent that is the subject of the health claim, OXY 280, which is a powder composed of kidney bean, olive and rosemary extracts, is sufficiently characterised. The claimed effect, reduction of body weight, is a beneficial physiological effect for overweight subjects. One unpublished human intervention study was provided by the applicant as pertinent to the health claim. This randomised, double-blind, placebo-controlled study investigated the effect of OXY 280 vs placebo on body weight, BMI, and waist, hip and thigh circumferences in 60 overweight subjects. The Panel notes that the results of between-group comparisons with respect to changes in the outcome variables assessed in this study were not provided. The Panel considers that the data as analysed do not allow the evaluation of the effect of the food constituent on changes in body weight relative to the placebo, and that no conclusions can be drawn from this study for the scientific substantiation of the claim. The Panel notes that no studies from which conclusions could be drawn for the scientific substantiation of the claim were provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between the consumption of OXY 280 and a reduction in body weight.

  4. Scientific Opinion on the substantiation of a health claim related to EffEXT™ and maintenance of normal joint mobility pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-12-01

    Full Text Available Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to EffEXT™ and maintenance of normal joint mobility. The Panel considers that EffEXT™, which is standardised pure krill oil, is sufficiently characterised. The claimed effect proposed by the applicant is “contributes to support joint flexibility”. The Panel considers that maintenance of normal joint mobility is a beneficial physiological effect. The applicant identified one human intervention study as being pertinent to the health claim. The Panel notes that chronic inflammation was an inclusion criterion of the study, that a significant number of the patients recruited were reported to have confirmed diagnosis of osteoarthritis, rheumatoid arthritis, or of both cardiovascular disease and osteoarthritis, and that the WOMAC osteoarthritis questionnaire was administered only to patients with arthritic disease (osteoarthritis or rheumatoid arthritis. The Panel also notes that no evidence which could justify the extrapolation of the results, obtained in patients with joint diseases characterised by chronic inflammation, to the target population, subjects without chronic joint diseases, was provided by the applicant. The Panel considers that no conclusions can be drawn from this study for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of EffEXT™ and maintenance of normal joint mobility.

  5. Scientific Opinion on the substantiation of a health claim related to a standardised aqueous extract from white kidney bean (Phaseolus vulgaris L. and reduction of body weight pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-07-01

    Full Text Available Following an application from InQpharm Europe Ltd, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to a standardised aqueous extract from white kidney bean (Phaseolus vulgaris L. and reduction of body weight. The Panel considers that the food is sufficiently characterised. A reduction in body weight is a beneficial physiological effect for overweight individuals. The applicant identified a total of four human intervention studies which investigated the effects of the aqueous extract from white kidney bean on body weight as being pertinent to the claim. No conclusions could be drawn from two of these four studies. In weighing the evidence, the Panel took into account that one human intervention study showed an effect of the standardised aqueous extract from white kidney bean in reducing body weight when consumed for 12 weeks, that the reduction in body weight was mostly through a reduction in body fat and that the effect of the standardised aqueous extract from white kidney bean on body weight was supported by a second study of shorter duration. However, the Panel also took into account that the first study was at risk of bias, that the supportive study suffered from methodological limitations and that no evidence was provided for a mechanism by which the standardised aqueous extract from white kidney bean could exert the claimed effect. The Panel concludes that the evidence provided is insufficient to establish a cause and effect relationship between the consumption of the standardised aqueous extract from white kidney bean (Phaseolus vulgaris L. and reduction of body weight.

  6. 小干扰RNA 抑制Pokemon表达对肺癌细胞A549和食管癌细胞EC109增殖的影响%Effects of Down-regulating Pokemon Expression by siRNA on Proliferation of Lung Cancer Cell A549 and Esophageal Cancer Cell EC109

    Institute of Scientific and Technical Information of China (English)

    沈惠琳; 叶月芳; 丛德刚

    2014-01-01

    目的:探讨Pokemon特异性小干扰RNA对肺癌细胞A549和食管癌细胞EC109 增殖的影响.方法:瞬时转染Pokemon特异性小干扰RNA至肺癌细胞A549和食管癌细胞EC109,RT-PCR、Western Blot技术检测转染后细胞中Pokemon的mRNA和蛋白表达水平,检测细胞的增殖及细胞周期变化.结果:与空白组和阴性对照组相比,瞬时转染Pokemon小干扰RNA后,肺癌细胞A549和食管癌细胞EC109中Pokemon的mRNA水平均下降至25%~35%,蛋白水平亦明显下降.细胞增殖能力在培养24,48,72 h均显著降低(P<0.05).细胞周期分析显示转染Pokemon小干扰RNA后S期的比例显著高于siRNA阴性对照组(A549细胞:55.7%±2.5% vs 42.7%±0.6%,P<0.01;EC109细胞:67.7%±2.5% vs 52.0%±2.0%,P<0.01).G1期的比例显著低于siRNA阴性对照组(A549细胞:33.0%±2.0% vs 45.3%±1.5%,P<0.01;EC109细胞:30.7%±1.2% vs 44.0%±1.7%,P<0.01).两种细胞均阻滞于S期.结论:Pokemon小干扰RNA可抑制肺癌细胞A549和食管癌细胞EC109 的增殖.

  7. 78 FR 30739 - Amendments to the 2013 Escrows Final Rule under the Truth in Lending Act (Regulation Z)

    Science.gov (United States)

    2013-05-23

    ... Standards under the Truth in Lending Act (Regulation Z) (2013 ATR Final Rule), 78 FR 6407 (Jan. 30, 2013... Procedures Act (Regulation X) (2013 RESPA Servicing Final Rule), 78 FR 10695 (Feb. 14, 2013); Mortgage Servicing Rules Under the Truth in Lending Act (Regulation Z) (2013 TILA Servicing Final Rule), 78 FR...

  8. Assumptions used in determining the radiation exposure according to the amended Radiation Protection Ordinance, and required adjustments in the General Administrative Regulation relating to paragraph 45 of the Radiation Protection Ordinance

    International Nuclear Information System (INIS)

    Within the framework of the amendment of the Radiation Protection Ordinance, the need arises to also amend the General Administrative Regulation on calculation of the radiation exposure due to radioactivity release with gaseous or liquid effluents, for the purpose of verification of compliance with the dose limits given in section 45 of the Radiation Protection Ordinance. The General Administrative regulation has to be harmonized with European legislation, EURATOM Directive 96/29. The required consultations for decision making have been a task of the working group for 'Anpassung der radiooekologischen Berechnungsgrundlage', of the Radioecology Committee of the SSK. The paper discusses the resulting draft document for amendment presented to and accepted by the SSK Committee. The document is awaiting discussion for final decision among members of the SSK, and between the SSK and representatives of Land governments as well as various bodies representing interests. (orig./CB)

  9. Clean/alternative fueled fleet programs - 1990 Amendments to the Clean Air Act, the Colorado Air Pollution Prevention and Control Act, and Denver City and County regulations

    International Nuclear Information System (INIS)

    Despite substantial regulations for nearly two decades, attainment of this ambient standards for ozone and carbon monoxide (CO) remain difficult goals to achieve, Even with of ozone precursors and CO. The 1990 Amendments to the Clean Air Act (CAA90) prescribe further reductions of mobile source emissions. One such reduction strategy is using clean fuels, such as methanol, ethanol, or other alcohols (in blends of 85 percent or more alcohol with gasoline or other fuel), reformulated gasoline or diesel, natural gas, liquified petroleum gas, hydrogen, or electricity. There are regulatory measures involving special fuels which will be required in areas heavily polluted with ozone and CO. The state of Colorado recently passed the 1992 Air Pollution Prevention and Control Act which included provisions for the use of alternative fuels which will be implemented in 1994. In addition to adhering to the Colorado state regulations, the city and county of Denver also have regulations pertaining to the use of alternative fuels in fleets of 10 or more vehicles. Denver's program began in 1992. This paper will address the issue of fleet conversion and its impact on industry in Colorado, and Denver in particular

  10. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to Lactobacillus paracasei LPC 01 (CNCM I-1390) and treatment of disease (ID 3055, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to provide a scientific opinion on a health claim pursuant to Article 13 of Regulation (EC) No 1924/2006 in the framework of further assessment related to Lactobacillus...... paracasei LPC 01 (CNCM I-1390) and treatment of disease. The food constituent, L. paracasei LPC 01 (CNCM I-1390), is sufficiently characterised. The claimed effect proposed for further assessment is “relieve symptoms typically associated with Irritable Bowel Syndrome (IBS), especially diarrhoea......”. The Panel considers that the claimed effect is related to the treatment of a disease and does not comply with the criteria laid down in Regulation (EC) No 1924/2006....

  11. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to alpha-cyclodextrin and reduction of post-prandial glycaemic responses (ID 2926, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a health claim pursuant to Article 13.1 of Regulation (EC) No 1924/2006 in the framework of further assessment related to alpha-cyclodextrin and r......Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a health claim pursuant to Article 13.1 of Regulation (EC) No 1924/2006 in the framework of further assessment related to alpha......), may be a beneficial physiological effect. The proposed target population is individuals who wish to reduce their post-prandial glycaemic responses. In weighing the evidence, the Panel took into account that two intervention studies showed a significant effect of alpha-cyclodextrin added to starch...

  12. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to lutein and maintenance of normal vision (ID 1603, 1604, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006 in the framework of further assessment related to lutein and mainte......Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006 in the framework of further assessment related to lutein...... into account that one human intervention study in healthy subjects did not show an effect of lutein on visual acuity or glare sensitivity, that the results of this study were inconsistent as regards contrast sensitivity, and that the evidence provided for a mechanism by which lutein could exert the claimed...

  13. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to Slendesta® Potato Extract and reduction of body weight pursuant to Article 13(5) of Regulation (EC) No 19 24/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Kemin Foods LC, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scient......Following an application from Kemin Foods LC, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...... effect for overweight individuals. In weighing the evidence, the Panel took into account that all four human intervention studies from which conclusions could be drawn for the scientific substantiation of the claim did not show an effect of Slendesta® Potato Extract on the reduction of body weight...

  14. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Sc ientific Opinion on the substantiation of a health claim related to Vichy Catalan carbonated natural mineral water and reduction of post - prandial lip a emic response pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from S.A. Vichy Catalan, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Spain, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scie......Following an application from S.A. Vichy Catalan, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Spain, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion......, reduction of post-prandial lipaemic response, is a beneficial physiological effect. In weighing the evidence, the Panel took into account that the results of the only study from which conclusions could be drawn for the scientific substantiation of the claim do not support an effect of Vichy Catalan...

  15. Scientific Opinion on the substantiation of a health claim related to non digestible carbohydrates and a reduction of post prandial glycaemic responses pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2014-01-01

    Full Text Available Following an application from Beneo-Orafti SA, Sensus BV and Cosucra-Groupe Warcoing SA, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to fructo-oligosaccharides (FOS from inulin and a reduction of post-prandial glycaemic responses. Non-digestible carbohydrates including FOS are resistant to hydrolysis and absorption in the small intestine and do not contribute to post-prandial glycaemia. This opinion applies to non-digestible carbohydrates (e.g. non-starch polysaccharides, resistant oligosaccharides and resistant starch which should replace sugars in foods or beverages in order to obtain the claimed effect. The Panel considers that the food constituent, non-digestible carbohydrates, which is the subject of the health claim, and the food constituent (i.e. sugars that non-digestible carbohydrates should replace in foods or beverages, are both sufficiently characterised in relation to the claimed effect. The Panel considers that a reduction of post-prandial glycaemic responses might be a beneficial physiological effect. In weighing the evidence, the Panel took into account that consumption of non-digestible carbohydrates results in reduced post-prandial blood glucose (and insulinaemic responses compared with the consumption of sugars on a weight-by-weight basis owing to the non-digestibility in the small intestine and to a decrease in the amount of available carbohydrates, and that the consumption of foods/drinks in which non-digestible carbohydrates replaced sugars induced lower post-prandial glycaemic and insulinaemic responses than sugar-containing foods/drinks. The Panel concludes that a cause and effect relationship has been established between the consumption of foods/beverages containing non

  16. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to foods with reduced lactose content and decreasing gastro-intestinal discomfort caused by lactose intake in lactose intolerant individuals (ID 646, 1224, 1238, 1339) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2011-01-01

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health claims in relation to foods with reduced lactose content and decreasing gastro-intestinal discomfort caused by lactose intake in lactose intolerant individuals. The scientific substantiation is based on ...

  17. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to Preservation ® and “ rapid recovery of cellular activity post stress ” pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    substantiation of a health claim related to Preservation® and “rapid recovery of cellular activity post stress”. The Panel considers that Preservation®, which contains an extract of prickly pear cactus Opuntia ficus-indica, is sufficiently characterised. The claimed effect is “rapid recovery of cellular activity...... laid down in Regulation (EC) No 1924/2006. © European Food Safety Authority, 2013...

  18. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) , 2014 . Scientific Opinion on the substantiation of a health claim related to Rosbacher drive® and increased attention pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2014-01-01

    Following an application from Hassia Mineralquellen GmbH & Co KG, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to Rosbacher drive® and increased attention. The Panel considers that Rosbacher drive®, which contains natural mineral water ...

  19. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) and maintenance of normal blood pressure (ID 661, 1831, 1832, 2891, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 (further reassessment)

    OpenAIRE

    Tetens, Inge

    2012-01-01

    Following a request from the European Commission, pursuant to Article 13.1 of Regulation (EC) No 1924/2006, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a health claim related to isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) and maintenance of normal blood pressure. The food constituent that is the subject of the claim, the tripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), is sufficiently ...

  20. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to “αS1-casein tryptic hydrolysate” and alleviation of psychological stress (ID 656, 1819, 4253) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2011-01-01

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health claims in relation to “αS1-casein tryptic hydrolysate” and alleviation of psychological stress. The scientific substantiation is based on the information provided by the Member States in the consolidated...

  1. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2012-01-01

    Following two applications from Nutrilinks Sarl, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil (Cucurbita pepo L.) and maintenance of normal hair. The Panel considers that t...

  2. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to ribose and faster recovery from muscle fatigue after exercise (ID 4226) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2011-01-01

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health claims in relation to ribose and faster recovery from muscle fatigue after exercise. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Ar...

  3. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific Opinion on the substantiation of a health claim related to vitamin D and contribution to the normal function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2015-01-01

    Following an application from VAB-nutrition, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to vitamin D and contribution to the normal function of the immune system. The Panel considers that vitamin D is sufficiently characterised. Contribution ...

  4. Hate Speech and the First Amendment.

    Science.gov (United States)

    Rainey, Susan J.; Kinsler, Waren S.; Kannarr, Tina L.; Reaves, Asa E.

    This document is comprised of California state statutes, federal legislation, and court litigation pertaining to hate speech and the First Amendment. The document provides an overview of California education code sections relating to the regulation of speech; basic principles of the First Amendment; government efforts to regulate hate speech,…

  5. 75 FR 6095 - Amendments to the Section 7216 Regulations-Disclosure or Use of Information by Preparers of...

    Science.gov (United States)

    2010-02-08

    ..., January 4, 2010 (75 FR 48) providing rules relating to the disclosure and use of tax return information by...--Disclosure or Use of Information by Preparers of Returns; Correction AGENCY: Internal Revenue Service (IRS... regulations (TD 9478), that are the subject of FR Doc. E9-31115, are corrected as follows: 0 On page...

  6. 78 FR 39901 - Amendments to the 2013 Mortgage Rules Under the Equal Credit Opportunity Act (Regulation B), Real...

    Science.gov (United States)

    2013-07-02

    ... and loan originator organizations to structure their compensation programs for 2013 to pay non... organization would have to apply the new proxy provisions and definition of a term of a transaction... Bureau issued Escrow Requirements Under the Truth in Lending Act (Regulation Z), 78 FR 4726 (Jan....

  7. 75 FR 48 - Amendments to the Section 7216 Regulations-Disclosure or Use of Information by Preparers of Returns

    Science.gov (United States)

    2010-01-04

    ... the IRS issued final regulations under section 7216 (TD 9375) (73 FR 1058) applicable to disclosures... compilations unless the disclosure is made in order to comply with financial accounting or regulatory reporting...--Disclosure or Use of Information by Preparers of Returns AGENCY: Internal Revenue Service (IRS),...

  8. 77 FR 36428 - Amendment to the International Traffic in Arms Regulations: Definition for “Specially Designed”

    Science.gov (United States)

    2012-06-19

    ... draft definition for ``specially designed'' in the December 2010 ANPRM (75 FR 76935) and noted the term... with the subject line, ``Specially Designed Definition.'' Internet: At www.regulations.gov , search for...: Revising Descriptions of Items and Foreign Availability,'' 75 FR 76664 (December 9, 2010) and...

  9. 76 FR 80302 - Amendment to the International Traffic in Arms Regulations: Revision of U.S. Munitions List...

    Science.gov (United States)

    2011-12-23

    ..., developed under a contract with the U.S. Department of Defense. (d) *(e) Naval nuclear propulsion plants... integrated with nuclear propulsion systems; (5) are armed or are ``specially designed'' to be used as a... Traffic in Arms Regulations (ITAR) to revise Category VI (surface vessels of war and special...

  10. 78 FR 36041 - Regulation of Fuels and Fuel Additives: RFS Pathways II and Technical Amendments to the RFS 2...

    Science.gov (United States)

    2013-06-14

    ... efforts such as plastic and rubber of fossil origin.'' Testing could identify the portion of the fuel... interpreted the definition of cellulosic biofuel as including in some cases a renewable fuel that is produced... June 14, 2013 Part II Environmental Protection Agency 40 CFR Part 80 Regulation of Fuels and...

  11. 75 FR 41084 - Amendments to Regulations Regarding Major Life-Changing Events Affecting Income-Related Monthly...

    Science.gov (United States)

    2010-07-15

    ....regulations.gov or in person, during regular business hours, by arranging with the contact person identified... document is available on the date of publication in the Federal Register at http://www.gpoaccess.gov/fr... Security Act provides that major life-changing events include marriage, divorce, death of ] spouse,...

  12. Explanatory material for the IAEA regulations for the safe transport of radioactive material (1985 edition). 2. ed. (as amended 1990)

    International Nuclear Information System (INIS)

    This publication is an updated version of the Second Edition of the Explanatory Material for the IAEA Regulations for the Safe Transport of Radioactive Material (1985 Edition) and replaces all previous versions of Safety Series No. 7. This publication includes the changes to Safety Series No. 7 contained in the Regulations for the Safe Transport of Radioactive Material, 1985 Edition, Supplement 1988, as well as modifications adopted by the Review Panel that was convened in Vienna, 10-14 July 1989. For the convenience of the user, the old Safety Series style adopted in the original publication has been retained, although the old style has now been superseded by a new one, affecting the structure, the format and the cover of the Safety Series. It should be noted, however, that future editions will be published in the new style.

  13. The role of integrated resource planning, environmental externalities, and anticipation of future regulation in compliance planning under the Clean Air Act Amendments of 1990

    Energy Technology Data Exchange (ETDEWEB)

    Bernow, S.; Biewald, B.; Wulfsberg, K. [Tellus Institute, Boston, MA (United States)

    1993-07-01

    Utilities are developing sulfur dioxide (SO{sub 2}) emission compliance plans to meet limitations of the Clean Air Act Amendments of 1990 (CAAA). Compliance plans will have long-term effects on resource selection, fuel choice, and system dispatch. Use of integrated resource planning (IRP) is necessary to ensure compliance plans are consistent with the overall societal goals. In particular, environmental externalities must be integrated with the compliance planning process. The focus of the CAAA is on air pollution reduction, specifically acid gases and toxics, and attainment of National Ambient Air Quality Standards (NAAQS) for criteria pollutants. Title IV specifically focuses on sulfur dioxide with a national allowance trading system, while further regulation of toxics and nitrogen oxides is slated for additional study. Yet, compliance planning based narrowly upon today`s environmental regulations could fail to meet the broad goals of IRP if a larger array of environmental externalities is excluded from the analysis. Compliance planning must consider a broad range of environmental effects from energy production and use to (1) protect society`s long-term stake in environmental quality, and (2) ensure that today`s plans are rich enough to accommodate potential changes in regulation and national environmental goals. The explicit recognition of environmental effects, such as those associated with CO{sub 2} release, will result in prudent compliance plans that take advantage of current opportunities for pollution avoidance and have long-term viability in the face of regulatory change. By including such considerations, the mix of resources acquired and operated (supply and demand, existing and new, conventional and renewable, fuel type and fuel quality, pollution control, and dispatch protocols) will be robust and truly least-cost.

  14. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to “hypo-caloric snacks (KOT products)” and “contributes to reduce adipocyte size at the abdominal level in the context of a low-calorie diet” pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2011-01-01

    Following an application from Ceprodi KOT, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to “hypo-caloric snacks (KOT products)” and “contributes to reduce adipocyte size at the abdominal level in the context of a low-calorie diet”. The target population is overweight individuals who wish...

  15. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Omikron Italia S.r.l., submitted pursuant to Article 13.5 of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health...... claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone. The food that is a subject of the health claim, a combination of diosmin, troxerutin and hesperidin, is sufficiently characterised. The claimed effect, maintenance of normal venous tone...... of diosmin, troxerutin and hesperidin and the maintenance of normal venous tone....

  16. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to 3 g/day plant stanols as plant stanol esters and lowering blood LDL-cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2012-01-01

    Following an application from Raisio Nutrition Ltd, submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Finland, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to 3 g/day plant stanols as plant stanol esters per day and lowering blood LDL-cholesterol by 12 % and reduced risk of (coronary) heart disease. The applicant has further requested that the min...

  17. Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)

    2012-01-01

    Following two applications from Nutrilinks Sarl, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil (Cucurbita pepo L.)...

  18. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to flaxseed oil and vitamin E and maintenance of the skin permeability barrier function pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim....... The applicant identified two published human intervention studies as being pertinent to the health claim. Owing to the very limited information provided regarding key methodological aspects, and to the important limitations of the statistical analysis performed, the Panel considers that no conclusions can...

  19. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to citrulline-malate and faster recovery from muscle fatigue after exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Biocodex, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related...... to the methodological limitations of the study. A number of mechanistic, animal and in vitro studies were submitted. In the absence of evidence for an effect of consumption of citrulline-malate on a faster recovery from muscle fatigue after exercise in humans, these studies cannot be used as a source of data...

  20. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to Vitis vinifera L. seeds extract and maintenance of normal venous blood flow pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim....... The applicant identified two human intervention studies as pertinent to the health claim. Owing to the very limited information provided in relation to one study, and that the second study was conducted with a food not complying with the characterisation of the food which is the subject of the health claim...

  1. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucose and contribution to energy-yielding metabolism pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    claim related to glucose and “contributes to normal energy-yielding metabolism”. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent that is the subject of the health claim is glucose, which is sufficiently......Following an application from Dextro Energy GmbH & Co. KG, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health...

  2. EFSA Panel on Di etetic Products, Nutrition and Allergie s (NDA); Scientific Opinion on the substantiation of a health claim relate d to OXY 280 and reduction of body weight pur suant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Actina, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related...... for overweight subjects. One unpublished human intervention study was provided by the applicant as pertinent to the health claim. This randomised, double-blind, placebocontrolled study investigated the effect of OXY 280 vs placebo on body weight, BMI, and waist, hip and thigh circumferences in 60 overweight...

  3. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to increasing maternal folate status by supplemental folate intake and reduced risk of neural tube defects pursuant to Article 14 of Regulation (EC

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Rank Nutrition Ltd, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...... characterised. Increasing maternal folate status by supplemental folate intake is a beneficial physiological effect in the context of reducing the risk of neural tube defects. In weighing the evidence, the Panel took into account that the association between low maternal folate intakes and an increased risk...

  4. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific Opinion on the substantiation of a health claim related to β-galactosidase from Kluyveromyces lactis in Colief® and a reduction of gastrointestinal discomfort pursuant to Article 14 of Regulation (EC

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Cross Vetpharm Group UK Ltd, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...... mechanism by which β-galactosidase could exert the claimed effect. In weighing the evidence, the Panel took into account that one study with methodological limitations showed an effect of β-galactosidase from Kluyveromyces lactis in Colief® on infant crying time, that no other human studies in which...

  5. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific Opinion on the substantiation of a health claim related to Symbiosal® and lowering of blood pressure and reduced risk of hypertension pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Han-Asiabiotech GmbH, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion....... Lowering of blood pressure is a beneficial physiological effect for people who want to lower their blood pressure. Increased blood pressure is a risk factor for hypertension. In weighing the evidence, the Panel took into account that one human study with methodological limitations showed a decrease...

  6. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to cocoa flavanols and maintenance of normal endothelium-dependent vasodilation pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Barry Callebaut Belgium nv, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation...... by the applicant is the general healthy adult population. The Panel considers that maintenance of normal endothelium-dependent vasodilation is a beneficial physiological effect. In weighing the evidence, the Panel took into account that cocoa flavanols consumed for 12 weeks have been shown to increase fasting ED...

  7. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to beta-alanine and increase in physical performance during short-duration, high-intensity exercise pursuant to Article 13(5) of Regulation (EC

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Natural Alternative International, Inc. (NAI), submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion...... performance during short-duration, high-intensity exercise is a beneficial physiological effect. In weighing the evidence the Panel took into account that only one out of 11 pertinent human intervention studies (including 14 pertinent outcomes) from which conclusions could be drawn showed an effect of beta...

  8. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to beta-palmitate and contribution to softening of stools pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...... physiological effect for infants. In weighing the evidence the Panel took into account that, out of two human intervention studies with important methodological limitations, one suggested a stool-softening effect of beta-palmitate whereas the second did not, that one animal study did not support a stool...

  9. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to vitamin K2 and contribution to the normal function of the heart and blood vessels (ID 125, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, pursuant to Article 13 of Regulation (EC) No 1924/2006, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a health claim related to vitamin K2 and contribution to the normal function of the heart....... In weighing the evidence, the Panel took into account the absence of human intervention studies from which conclusions could be drawn for the scientific substantiation of the claim, the inconsistency of the results reported in two cross-sectional studies regarding arterial calcification in women...

  10. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to coffee C21 and reduction of spontaneous DNA strand breaks pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2011-01-01

    Following an application from Tchibo GmbH, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to coffee C21 and reduction of spontaneous DNA strand breaks. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent...

  11. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) and maintenance of normal blood pressure pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Valio Ltd submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Finland, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related...... of which were adequately powered to detect small between-group differences in systolic BP (SBP), did not observe an effect of IPP and VPP on SBP or diastolic BP. The interpretation of the results from seven out of the eight studies which reported an effect of IPP and VPP on office SBP was hampered by major...

  12. Scientific Opinion on the substantiation of a health claim related to Vitis vinifera L. seeds extract and “helps to decrease swollen legs” pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-12-01

    Full Text Available Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to Vitis vinifera L. seeds extract and “helps to decrease swollen legs”. The Panel considers that the food constituent which is the subject of the health claim is sufficiently characterised. Upon EFSA’s request for clarification, the applicant stated that the claimed effect was “helps to decrease swollen legs”, and that the beneficial physiological effect could be related to “helps to refine legs”. In the context of the references provided for the scientific substantiation of the claim, and in particular of the human intervention study which was conducted with the food constituent that is the subject of the health claim, the Panel notes that the claim refers to the reduction of peripheral oedema in the context of chronic clinical conditions (e.g. chronic venous insufficiency where the reduction of peripheral oedema is a therapeutic target for the treatment of the condition. The Panel considers that the reduction of peripheral oedema in the context of chronic clinical conditions is a therapeutic target for the treatment of the condition and does not comply with the criteria laid down in Regulation (EC No 1924/2006.

  13. Scientific Opinion on the substantiation of a health claim related to EffEXT™ and “helps to support joint function by maintaining low levels of plasma C-reactive protein” pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-09-01

    Full Text Available

    Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to EffEXT™ and “helps to support joint function by maintaining low levels of plasma C‑reactive protein”. The Panel considers that EffEXT™, which is standardised pure krill oil, is sufficiently characterised. The claimed effect is “helps to support joint function by maintaining low levels of plasma C-reactive protein”. The Panel notes that the claim refers to a reduction of inflammation indicated by a lowered concentration of plasma C-reactive protein. Whether or not reduction of inflammatory markers is considered beneficial depends on the context in which a claim is made. In the context of the study provided, the Panel notes that the claim refers to diseases such as osteoarthritis or rheumatoid arthritis, in which a reduction of inflammation would be a therapeutic target for the treatment of the disease. The Panel considers that the reduction of inflammation in the context of diseases such as osteoarthritis or rheumatoid arthritis is a therapeutic target for the treatment of the disease and does not comply with the criteria laid down in Regulation (EC No 1924/2006.

  14. 77 FR 60883 - Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation of a Search...

    Science.gov (United States)

    2012-10-05

    ... information, utilizing OEI continuous and time-limited power ratings. (C) The maximum wind envelope... Administration 14 CFR Part 29 Special Conditions: Eurocopter France (ECF) Model EC225LP Helicopter, Installation... published in the Federal Register on November 6, 2008 (73 FR 65968). A notice proposing this amendment...

  15. Explosive Effectiveness Capability (ExEC)

    Energy Technology Data Exchange (ETDEWEB)

    Nakafuji, G.; Daily, L.; Leake, J.

    2000-07-26

    Gaining accurate predictions of damage inflicted by high explosive devices is vital in order to minimize collateral damage effects on a target. ExEC provides a means for conducting very detailed analysis of weapons effects on targets for advanced mission planning purposes. ExEC is composed of a suite of high fidelity physics codes, which have been used for decades by the nuclear weapons laboratories for assessing high explosive, thermal, and structural effects. The ExEC capability should not be confused with the fast running empirical codes MEA and MEVA, which are good for fast scoping analysis. MEA and MEVA rely on look-up tables or simple approximations to quickly obtain a rough estimate of weapon damage on a target. In contrast, the ExEC capability provides a much higher fidelity damage prediction and a limitless number of target configurations by solving the time dependent conservation equations for mass, momentum, and energy, in order to directly simulate the interaction of a weapon with a target component. In contrast, MEA/MEVA must be calibrated for every different weapon type and target. ExEC has produced accurate simulations for weapon disablement, shape charge penetration, sympathetic detonation, fragment damage effects, and blast effects. For example, ExEC was used to look at a DTRA test performed at White Sands Missile Range, Dipole Orbit 1 (DO1). In DO1, a BLU-109 bomb was statically detonated in a partially buried four-room building that was storing chemical and biological weapon simulants, as well as inactive equipment typical of a CBW (Chemical and Biological Warfare) facility. The blast wave (overpressure) histories were recorded and compared to an ExEC and MEVA simulation. A direct comparison between experimental data and calculations, for a single pressure gauge, indicated that MEVA had a 200% error compared to 5% for ExEC. In addition, ExEC tracks the time dependant fluctuations in pressure (for an accurate prediction of the impulse), while MEVA

  16. 45 CFR 5b.7 - Procedures for correction or amendment of records.

    Science.gov (United States)

    2010-10-01

    ... corrected or amended, the subject individual will be informed in writing of the refusal to correct or amend... 45 Public Welfare 1 2010-10-01 2010-10-01 false Procedures for correction or amendment of records... PRIVACY ACT REGULATIONS § 5b.7 Procedures for correction or amendment of records. (a) Any...

  17. Fate of Escherichia coli O157: H7 in agricultural soils amended with different organic fertilizers.

    Science.gov (United States)

    Yao, Zhiyuan; Yang, Li; Wang, Haizhen; Wu, Jianjun; Xu, Jianming

    2015-10-15

    Five organic fertilizers (vermicompost, pig manure, chicken manure, peat and oil residue) were applied to agricultural soils to study their effects on the survival of Escherichia coli O157:H7 (E. coli O157:H7). Results showed that E. coli O157:H7 survival changed greatly after organic fertilizers application, with shorter td values (survival time needed to reach the detection limit of 100 CFU g(-1)) (12.57±6.57 days) in soils amended with chicken manure and the longest (25.65±7.12 days) in soils amended with pig manure. Soil pH, EC and free Fe/Al (hydro) oxides were significant explanatory factors for E. coli O157:H7 survival in the original soils. Soil constituents (minerals and organic matter) and changes in their surface charges with pH increased the effect of soil pH on E. coli O157:H7 survival. However, electrical conductivity played a more important role in regulating E. coli O157:H7 survival in fertilizer-amended soils. This study highlighted the importance of choosing appropriate organic fertilizers in the preharvest environment to reduce food-borne bacterial contamination.

  18. Fate of Escherichia coli O157: H7 in agricultural soils amended with different organic fertilizers.

    Science.gov (United States)

    Yao, Zhiyuan; Yang, Li; Wang, Haizhen; Wu, Jianjun; Xu, Jianming

    2015-10-15

    Five organic fertilizers (vermicompost, pig manure, chicken manure, peat and oil residue) were applied to agricultural soils to study their effects on the survival of Escherichia coli O157:H7 (E. coli O157:H7). Results showed that E. coli O157:H7 survival changed greatly after organic fertilizers application, with shorter td values (survival time needed to reach the detection limit of 100 CFU g(-1)) (12.57±6.57 days) in soils amended with chicken manure and the longest (25.65±7.12 days) in soils amended with pig manure. Soil pH, EC and free Fe/Al (hydro) oxides were significant explanatory factors for E. coli O157:H7 survival in the original soils. Soil constituents (minerals and organic matter) and changes in their surface charges with pH increased the effect of soil pH on E. coli O157:H7 survival. However, electrical conductivity played a more important role in regulating E. coli O157:H7 survival in fertilizer-amended soils. This study highlighted the importance of choosing appropriate organic fertilizers in the preharvest environment to reduce food-borne bacterial contamination. PMID:25910457

  19. The EC-ASEAN COGEN programme

    Energy Technology Data Exchange (ETDEWEB)

    Pennington, M.; Lacrosse, L. [Asian Institute of Technology (Thailand); Schenkel, Y. [Centre de Recherches Agronomiques (Belgium)

    1996-12-31

    The EC-ASEAN COGEN Programme is a co-operation programme between the European Commission (EC) and the Association of South East Asian Nations (ASEAN) co-ordinated by the Asian Institute of Technology (AIT), Bangkok, Thailand. Its aim is to accelerate the implementation of proven technologies generating heat and/or power from wood and agroindustrial residues through partnerships between European and ASEAN companies. (orig.)

  20. Special Issue: Selected papers from ECS'97

    DEFF Research Database (Denmark)

    1999-01-01

    This Special Issue of Analog Integrated Circuits and Signal Processing presents extended versions of selected papers from the First Electronic Circuits and Systems Conference (ECS'97) which was held on September 4-5, 1997, in Bratislava, Slovakia.......This Special Issue of Analog Integrated Circuits and Signal Processing presents extended versions of selected papers from the First Electronic Circuits and Systems Conference (ECS'97) which was held on September 4-5, 1997, in Bratislava, Slovakia....

  1. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to polyphenols in olive and maintenance of normal blood HDL-cholesterol concentrations (ID 1639, further assessment) pursuant to Article 13(1) of Regulation (EC

    DEFF Research Database (Denmark)

    Tetens, Inge

    and maintenance of normal blood HDL-cholesterol concentrations. The food constituent, polyphenols in olive (olive fruit, olive mill waste waters or olive oil, Olea europaea L. extract and leaf) standardised by their content of hydroxytyrosol and its derivatives (e.g. oleuropein complex), that is the subject...... was insufficient to establish a cause and effect relationship between the consumption of olive oil polyphenols (standardised by the content of hydroxytyrosol and its derivatives) and maintenance of normal blood HDL cholesterol concentrations.......Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to provide a scientific opinion on a health claim pursuant to Article 13 of Regulation (EC) No 1924/2006 in the framework of further assessment related to polyphenols in olive...

  2. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to glycaemic carbohydrates and maintenance of normal brain function (ID 603, 653) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to glycaemic carbohydrates and maintenance of normal brain function. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from......; attention; memory”. The target population is assumed to be the general population. In the context of the proposed wordings, the Panel assumes that the claimed effects refer to the maintenance of normal brain function. The Panel considers that maintenance of normal brain function is a beneficial...

  3. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the modification of the authorisation of a health claim related to cocoa flavanols and maintenance of normal endotheliumdependent vasodilation pursuant to Article 13(5) of Regulation (EC) No 1924

    DEFF Research Database (Denmark)

    Tetens, Inge

    of the authorisation of a health claim related to “cocoa flavanols help maintain the elasticity of blood vessels, which contributes to normal blood flow”, pursuant to Article 13(5) of Regulation (EC) No 1924/2006. The modification concerns an extension of the authorised conditions of use of the claim to a high......-flavanols (HF) cocoa extract to be consumed in capsules, tablets or added to “other foods, including beverages”. Cocoa flavanols, which are the subject of the health claim, have been sufficiently characterised. Maintenance of normal endothelium-dependent vasodilation is a beneficial physiological effect....... The Panel concludes that a cause and effect relationship has been established between the consumption of cocoa flavanols in the HF cocoa extract (i.e. in capsules or tablets) and maintenance of normal endothelium-dependent vasodilation. In order to obtain the claimed effect, 200 mg of cocoa flavanols should...

  4. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to spermidine and prolongation of the growing phase (anagen) of the hair cycle pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Giuliani S.p.A., submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related...... to spermidine and prolongation of the growing phase (anagen) of the hair cycle. The scope of the application was proposed to fall under a health claim referring to a health claim based on newly developed scientific evidence and including a request for the protection of proprietary data. The food constituent...... that is the subject of the health claim is spermidine, which is sufficiently characterised. The claimed effect is prolongation of the growing phase (anagen) of the hair cycle. The target population proposed by the applicant is “healthy people affected by chronic telogen effluvium”. Following EFSA’s request to provide...

  5. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to spermidine and contribution to normal hair growth (ID 1705) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to spermidine and contribution to normal hair growth. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders...... assumes that the claimed effect refers to contribution to normal hair growth. The Panel considers that contribution to normal hair growth is a beneficial physiological effect. No references have been provided from which conclusions could be drawn for the scientific substantiation of the claim...

  6. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to iron and contribution to normal formation of haemoglobin and red blood cells pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Specialised Nutrition Europe (formerly IDACE), submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...... substantiation of a health claim related to iron and contribution to normal formation of haemoglobin and red blood cells. The food constituent, iron, which is the subject of the health claim, is sufficiently characterised. Contribution to normal formation of haemoglobin and red blood cells is a beneficial...... physiological effect for infants and young children. A claim on iron and contribution to normal formation of haemoglobin and red blood cells in the general population has already been assessed by the Panel with a favourable outcome. The Panel considers that the role of iron in normal formation of haemoglobin...

  7. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to lactose and increase in calcium absorption leading to an increase in calcium retention (ID 668) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to lactose and increase in calcium absorption leading to an increase in calcium retention. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member...... that the claimed effect (improved nutrient absorption) is only considered beneficial where absorption is a limiting factor for the maintenance of adequate status of the nutrient and where increased absorption leads to increased retention. The Panel considers that an increase in calcium absorption leading...

  8. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to DHA and contribution to normal brain development pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from DSM Nutritional Products, submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver...... an opinion on the scientific substantiation of a health claim related to docosahexaenoic acid (DHA) and contribution to normal brain development. The Panel considers that DHA is sufficiently characterised, and that contribution to normal brain development is a beneficial physiological effect for infants...... and contribution to normal brain development. The following wording reflects the scientific evidence: “DHA contributes to normal brain development”. In order to bear the claim, foods for older infants and young children below the age of 24 months should provide a daily intake of 100 mg DHA in one or more servings...

  9. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to Lactobacillus rhamnosus GG and maintenance of defence against pathogenic gastrointestinal microorganisms pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following an application from Valio Ltd., submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Finland, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related...... to Lactobacillus rhamnosus GG (LGG) and maintenance of defence against pathogenic gastrointestinal (GI) microorganisms. LGG is sufficiently characterised. The Panel considers that the health claim refers to the defence against GI pathogens in the general population without GI infections and does not include...... the treatment of GI infections. Maintenance of defence against pathogenic GI microorganisms is a beneficial physiological effect. Only one out of five human intervention studies showed an effect of LGG consumption on the development of GI infections, two human intervention studies did not show an effect of LGG...

  10. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to iodine and contribution to normal cognitive development pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    substantiation of a health claim related to iodine and contribution to normal cognitive development. The food constituent, iodine, which is the subject of the health claim, is sufficiently characterised. Contribution to normal cognitive development is a beneficial physiological effect for infants and young......Following an application from Specialised Nutrition Europe (formerly IDACE), submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...... children. A claim on iodine and contribution to normal cognitive and neurological function in the general population has already been assessed with a favourable outcome. In addition, there is a large body of evidence indicating a crucial role for iodine in growth and development. The Panel notes the well...

  11. EFSA NDA Panel (EFSA Panel on Dietetic Product s, Nutrition and Allergies), 2013 . Scientific Opinion on the substantiation of a health claim related to magnesium and contributio n to normal development of bone pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    to magnesium and contribution to normal development of bone. The food constituent, magnesium, which is the subject of the health claim, is sufficiently characterised. Contribution to normal development of bone is a beneficial physiological effect for infants and young children. A claim on magnesium......Following an application from IDACE, submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related...... and effect relationship has been established between dietary intake of magnesium and contribution to normal development of bone. The following wording reflects the scientific evidence: “Magnesium contributes to normal development of bone”. The target population is infants and children up to three years...

  12. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucose and contribution to energy-yielding metabolism pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    claim related to glucose and “contributes to normal muscle function”. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent that is the subject of the health claim is glucose, which is sufficiently characterised......Following an application from Dextro Energy GmbH & Co. KG, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health....... The claimed effect is “contributes to normal muscle function”. The proposed target population is healthy, active, as well as endurance trained, men and women. The Panel notes that the claimed effect refers to the contribution of the food constituent to energy-yielding metabolism in active individuals. Energy...

  13. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucose and contribution to energy-yielding metabolism pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    claim related to glucose and “it is metabolised within body’s normal energy metabolism”. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent that is the subject of the health claim is glucose, which is sufficiently......Following an application from Dextro Energy GmbH & Co. KG submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health...... characterised. The claimed effect is “it is metabolised within body’s normal energy metabolism”. The proposed target population is the general population. The Panel notes that the claimed effect refers to the contribution of the food constituent to energy-yielding metabolism, which is a beneficial physiological...

  14. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucose and contribution to energy-yielding metabolism pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    claim related to glucose and “supports normal physical activity”. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent that is the subject of the health claim is glucose, which is sufficiently characterised. The claimed......Following an application from Dextro Energy GmbH & Co. KG, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health...... effect is “supports normal physical activity”. The proposed target population is healthy, active, as well as endurance trained, men and women. The Panel notes that the claimed effect refers to the contribution of the food constituent to energy-yielding metabolism in active individuals. Energy...

  15. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014. Scientific Opinion on the substantiation of a health claim related to choline and “development of brain” pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    to deliver an opinion on the scientific substantiation of a health claim related to choline and “development of brain”. The food constituent, choline, which is the subject of the health claim, is sufficiently characterised. The claimed effect proposed by the applicant is “development of brain” and the target......Following an application from Specialised Nutrition Europe (formerly IDACE), submitted for authorisation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked...... population is infants and young children from birth to three years of age. Taking into account that no evidence was provided for an effect of dietary choline deficiency in the normal development of the brain in infants and young children, the Panel considers that the claimed effect, “development of brain...

  16. EFSA NDA Panel (EFSA Panel on Dietetic Product s, Nutrition and Allergies), 2013 . Scientific Opinion on the substantiation of a health claim related to vitamin A and contribution to normal development and function of the immune system pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    to vitamin A and contribution to normal development and function of the immune system. The food constituent, vitamin A, which is the subject of the health claim, is sufficiently characterised. Contribution to normal development and function of the immune system is a beneficial physiological effect......Following an application from IDACE, submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related...... for infants and young children. A claim on vitamin A and normal function of the immune system in the general population has already been assessed with a favourable outcome. The Panel notes that the role of vitamin A in the normal function of the immune system also applies to the developing immune system...

  17. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to glucose and contribution to energy-yielding metabolism pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    claim related to glucose and “contributes to normal energy-yielding metabolism during exercise”. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent that is the subject of the health claim is glucose, which......Following an application from Dextro Energy GmbH & Co. KG, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health...... is sufficiently characterised. The claimed effect is “contributes to normal energy-yielding metabolism during exercise”. The proposed target population is healthy, active, as well as endurance trained, men and women. The Panel notes that the claimed effect refers to the contribution of the food constituent...

  18. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 20 13 . Scientific Opinion on the substantiatio n of a health claim related to iron and contribution to normal cognitive development pursuant to Article 14 of Regulation (EC ) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    to iron and contribution to normal cognitive development. The food constituent, iron, which is the subject of the health claim, is sufficiently characterised. Contribution to normal cognitive development is a beneficial physiological effect for infants and young children. A claim on iron and cognitive......Following an application from IDACE, submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related...... established between dietary intake of iron and contribution to normal cognitive development. The following wording reflects the scientific evidence: “Iron contributes to normal cognitive development”. The target population is infants and children up to three years. © European Food Safety Authority, 2013...

  19. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2014 . Scientific Opinion on the substantiation of a health claim related to vitamin D and contribution to normal bone and tooth development pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    substantiation of a health claim related to vitamin D and contribution to normal development of bones and teeth. The food constituent, vitamin D, which is the subject of the health claim, is sufficiently characterised. Contribution to normal development of bones and teeth is a beneficial physiological effect......Following an application from Specialised Nutrition Europe (formerly IDACE), submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific...... and young children (from birth to three years). The Panel concludes that a cause and effect relationship has been established between the dietary intake of vitamin D and contribution to normal development of bones and teeth....

  20. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to coffee C21 and reduction of spontaneous DNA strand breaks pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    to coffee C21 and reduction of spontaneous DNA strand breaks. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food constituent that is the subject of the health claim is coffee C21, which is sufficiently characterised. The claimed......Following an application from Tchibo GmbH, submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related...... relationship has not been established between the consumption of coffee C21 and a reduction in spontaneous DNA strand breaks. © European Food Safety Authority, 2011...

  1. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to sodium and maintenance of normal muscle function (ID 359) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health....... The food constituent that is the subject of the health claim is sodium. The Panel considers that sodium is sufficiently characterised. The claimed effect is “muscle function”. The target population is assumed to be the general population. The Panel considers that maintenance of normal muscle function...... claims in relation to sodium and maintenance of normal muscle function. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders...

  2. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to arabinoxylan produced from wheat endosperm and reduction of post-prandial glycaemic responses (ID 830) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of a health...... claim in relation to arabinoxylan produced from wheat endosperm and reduction of post-prandial glycaemic responses. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from...... responses. The Panel considers that the reduction of post-prandial glycaemic responses (as long as post-prandial insulinaemic responses are not disproportionally increased) may be a beneficial physiological effect. In weighing the evidence, the Panel took into account that one well-designed intervention...

  3. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to sodium alginate and reduction of post-prandial glycaemic responses (ID 1868, 1881) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to sodium alginate and reduction of post-prandial glycaemic responses. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from....... The Panel considers that the reduction of post-prandial glycaemic responses (as long as post-prandial insulinaemic responses are not disproportionally increased) may be a beneficial physiological effect. In weighing the evidence, the Panel took into account that the one human intervention study provided...

  4. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to oat and barley grain fibre and increase in faecal bulk (ID 819, 822) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to oat and barley grain fibre and increase in faecal bulk. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders...... the evidence, the Panel took into account that the role of cereal grain fibre in increasing faecal bulk in humans is well established, that the mechanisms by which cereal grain fibre exerts the claimed effect are known, that oat fibre has a significant bulking effect in humans, and that a similar effect can...

  5. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to folate and maintenance of normal blood pressure (ID 176) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to folate and maintenance of normal blood pressure. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders...... that the claimed effect relates to the maintenance of normal blood pressure. The Panel considers that maintenance of normal blood pressure is a beneficial physiological effect. In weighing the evidence, the Panel took into account that no human intervention studies from which conclusions could be drawn...

  6. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to fructose and reduction of post-prandial glycaemic responses (ID 558) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to fructose and reduction of post-prandial glycaemic responses. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from......-prandial insulinaemic responses are not disproportionally increased) may be a beneficial physiological effect. In weighing the evidence, the Panel took into account that the few intervention studies in healthy and type 2 diabetic subjects provided showed a consistent significant reduction in post-prandial glycaemic...

  7. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to medium-chain triglycerides and reduction in body weight (ID 643, 677, 1614) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health...... claims in relation to medium-chain triglycerides and reduction in body weight. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from...... to be overweight individuals in the general population who wish to reduce their body weight. The Panel considers that reduction in body weight is a beneficial physiological effect. In weighing the evidence, the Panel took into account that the results from the human intervention studies provided are inconsistent...

  8. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to Lactobacillus rhamnosus GR-1 (ATCC 55826) in combination with Lactobacillus reuteri RC-14 (ATCC 55845) and defence against vaginal pathogens by increasing the proportion of lactobacilli and/or decreasing the proportion of potentially pathogenic bacteria and/or yeasts (ID 945) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2011-01-01

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health claims in relation to Lactobacillus rhamnosus GR-1 (ATCC 55826) in combination with Lactobacillus reuteri RC-14 (ATCC 55845) and defence against vaginal pathogens by increasing the proportion of lactobac...

  9. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to policosanols from sugar cane wax and maintenance of normal blood LDL-cholesterol concentrations (ID 1747, 1748, 1864, 1951, 1954, 4693) and maintenance of normal blood HDL-cholesterol concentrations (ID 1747, 1748, 1864, 1951, 1954, 4693) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2011-01-01

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health claims in relation to policosanols from sugar cane wax and maintenance of normal blood LDL-cholesterol concentrations and maintenance of normal blood HDL-cholesterol concentrations. The scientific substa...

  10. 48 CFR 452.215-72 - Amendments to Proposals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Amendments to Proposals. 452.215-72 Section 452.215-72 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CLAUSES... vertical lines adjacent to the change. The offeror shall include the date of the amendment on the...

  11. Amendment 80 Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Amendment 80 Program was adopted by the North Pacific Fishery Management Council (Council) in June 2006. The final rule implementing Amendment 80 published in...

  12. Determination of primary combustion source organic carbon-to-elemental carbon (OC / EC) ratio using ambient OC and EC measurements: secondary OC-EC correlation minimization method

    Science.gov (United States)

    Wu, Cheng; Zhen Yu, Jian

    2016-05-01

    Elemental carbon (EC) has been widely used as a tracer to track the portion of co-emitted primary organic carbon (OC) and, by extension, to estimate secondary OC (SOC) from ambient observations of EC and OC. Key to this EC tracer method is to determine an appropriate OC / EC ratio that represents primary combustion emission sources (i.e., (OC / EC)pri) at the observation site. The conventional approaches include regressing OC against EC within a fixed percentile of the lowest (OC / EC) ratio data (usually 5-20 %) or relying on a subset of sampling days with low photochemical activity and dominated by local emissions. The drawback of these approaches is rooted in its empirical nature, i.e., a lack of clear quantitative criteria in the selection of data subsets for the (OC / EC)pri determination. We examine here a method that derives (OC / EC)pri through calculating a hypothetical set of (OC / EC)pri and SOC followed by seeking the minimum of the coefficient of correlation (R2) between SOC and EC. The hypothetical (OC / EC)pri that generates the minimum R2(SOC,EC) then represents the actual (OC / EC)pri ratio if variations of EC and SOC are independent and (OC / EC)pri is relatively constant in the study period. This Minimum R Squared (MRS) method has a clear quantitative criterion for the (OC / EC)pri calculation. This work uses numerically simulated data to evaluate the accuracy of SOC estimation by the MRS method and to compare with two commonly used methods: minimum OC / EC (OC / ECmin) and OC / EC percentile (OC / EC10 %). Log-normally distributed EC and OC concentrations with known proportion of SOC are numerically produced through a pseudorandom number generator. Three scenarios are considered, including a single primary source, two independent primary sources, and two correlated primary sources. The MRS method consistently yields the most accurate SOC estimation. Unbiased SOC estimation by OC / ECmin and OC / EC10 % only occurs when the left tail of OC / EC

  13. Grout Analysis for EC and CC Calorimeters

    Energy Technology Data Exchange (ETDEWEB)

    Engstrom, L.L.; /Fermilab

    1987-01-06

    The EC and CC calorimeters roll on Two parallel hardened steel ways which reside on the top of the D0 platform's center beam. The ways will be grouted to the center beam once their correct elevation has been established. The purpose of this report is to evaluate and compare three different epoxy grouts and their properties for this application.

  14. The EC discourse on vocational training

    DEFF Research Database (Denmark)

    Cort, Pia

    2009-01-01

    This article traces the EC vocational training policy historically and describes the discursive alignments which brought the policy from a ‘common vocational training policy' as laid down in Article 128, in the Treaty of Rome to the Lisbon Lifelong Learning strategy. The argument is that vocational...

  15. Amendment of the Atomic Law. Need of aopproval according to the Constitutional Law and EU competencies for the regulation of the nuclear safety

    International Nuclear Information System (INIS)

    The in the context of the European Atomic Energy Community (Euratom) issued for the dumping of waste disposals and for the safe disposal of radioactive wastes planned secondary legislation concerns to the nuclear safety. The scope of competence is reduced in this range. For the amendment of the atomic law, also covering the extension of power plant operation, essentially substantial points of contact exist, and an independent field of problem develops. This happens in addition to anyway disputed demand of agreement of the Federal Council for the change of the Atomic Energy Act according to Sect. 87c Constitutional Law also having a European legal determinant. The last question did not dominate by the fact that the legal committee of the Federal Council in its meeting at 10th November, 2010, voted by majority that the atomic novella for the extension of power plant operation is obligated for agreement. However, this vote is not binding for the plenum.

  16. Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-07-01

    Full Text Available

    Following two applications from Nutrilinks Sarl, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil (Cucurbita pepo L. and maintenance of normal hair. The Panel considers that the specified combination is sufficiently characterised. The claimed effects are “contributes to reduce hair loss” and “increases the number of hair”. The target population proposed by the applicant is healthy adults in the general population. The Panel considers that maintenance of normal hair is a beneficial physiological effect. The applicant identified one publication as being pertinent to the health claim. This study did not use the food which is the subject of the claim. No conclusions can be drawn from this study for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil (Cucurbita pepo L. and maintenance of normal hair.

  17. Scientific Opinion on the substantiation of a health claim related to OptiEFAX™ and maintenance of normal blood HDL-cholesterol concentrations pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-07-01

    Full Text Available

    Following an application from Nutrilinks Sarl, submitted for authorisation of a health claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to OptiEFAX™ and maintenance of normal blood HDL-cholesterol concentrations. The food that is the subject of the health claim, OptiEFAX™, which is standardised pure krill oil, is sufficiently characterised in relation to the claimed effect. The claimed effect, maintenance of normal blood HDL-cholesterol concentrations, is a beneficial physiological effect. The target population proposed by the applicant is the general population. No human studies have been provided from which conclusions could be drawn for the scientific substantiation of the claim. A cause and effect relationship has not been established between the consumption of OptiEFAX™ and maintenance of normal blood HDL-cholesterol concentrations.

  18. Scientific Opinion on the substantiation of a health claim related to OptiEFAX™ and maintenance of normal blood LDL-cholesterol concentrations pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-07-01

    Full Text Available

    Following an application from Nutrilinks Sarl, submitted for authorisation of a claim pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to OptiEFAX™ and maintenance of normal blood LDL-cholesterol concentrations. The food that is the subject of the health claim, OptiEFAX™, which is standardised pure krill oil, is sufficiently characterised in relation to the claimed effect. The claimed effect, maintenance of normal blood LDL-cholesterol concentrations, is a beneficial physiological effect. The target population proposed by the applicant is the general population. No human studies have been provided from which conclusions could be drawn for the scientific substantiation of the claim. A cause and effect relationship has not been established between the consumption of OptiEFAX™ and maintenance of normal blood LDL-cholesterol concentrations.

  19. Scientific Opinion on the substantiation of a health claim related to a combination of Paullinia cupana Kunth (guarana and Camellia sinensis (L. Kuntze (green tea extracts and reduction of body weight pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-12-01

    Full Text Available Following an application from Nutrilinks Sarl, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Cyprus, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of Paullinia cupana Kunth (guarana and Camellia sinensis (L. Kuntze (green tea extracts and reduction of body weight. The Panel considers that the food constituent which is the subject of the health claim is sufficiently characterised. The claimed effect, reduction of body weight, is a beneficial physiological effect for overweight subjects. One human intervention study from which no conclusions could be drawn for the scientific substantiation of the claim was provided by the applicant. The Panel concludes that a cause and effect relationship has not been established between the consumption of a combination of Paullinia cupana Kunth (guarana and Camellia sinensis (L. Kuntze (green tea extracts and a reduction in body weight.

  20. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of a health claim related to 3 g/day plant sterols/stanols and lowering blood LDL-cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    of an application to modify the conditions of use of an authorised Article 14 claim related to 1.5 - 3.0 g plant sterols/stanols per day and lowering blood LDL-cholesterol by 7 - 12 % and reduced risk of (coronary) heart disease. The applicant has further requested that the minimum duration to obtain the effect...... be one to two weeks. The applicant provided a published systematic review and meta-analysis that evaluated the comparative efficacy of plant sterols and plant stanols for lowering blood LDL-cholesterol in healthy and hypercholesterolaemic subjects and an unpublished meta-analysis on 27 randomised....../2010 (yellow fat spreads, dairy products, mayonnaise and salad dressings) have a similar efficacy on blood LDL-cholesterol lowering, that plant sterols and stanol esters at a daily intake of 3 g (range 2.6 g to 3.4 g) plant sterols/stanols in matrices approved by Regulation (EC) No 376/2010 lower LDL-cholesterol...

  1. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard and white Swiss chard and protection of blood lipids from oxidative damage pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2013-01-01

    Following an application from Italsur s.r.l., submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard and white Swiss chard and protection of blood ...

  2. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on the substantiation of a health claim related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard and white Swiss chard and maintenance of normal blood LDL-cholesterol concentration pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    OpenAIRE

    Tetens, Inge

    2013-01-01

    Following an application from Italsur s.r.l., submitted pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Italy, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to a combination of red spinach, green spinach, red chicory, green chicory, green leaf chard, red leaf chard, red Swiss chard, golden Swiss chard and white Swiss chard and maintenance of norma...

  3. Scientific Opinion of the Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-CZ-2006-33) for the placing on the market of the insect-resistant and glyphosate-tolerant genetically modified maize MON 88017 x MON 810, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto:(Question No EFSA-Q-2006-020)

    OpenAIRE

    Sørensen, Ilona Kryspin

    2009-01-01

    Following a request from Monsanto within the framework of Regulation (EC) No 1829/2003 on genetically modified food and feed, the Panel on Genetically Modified Organisms was asked to deliver a scientific opinion on the authorisation of the insect-resistant, glyphosatetolerant genetically modified maize MON 88017 x MON 810 (Unique Identifier MON88Ø17- 3 x MON-ØØ81Ø-6). In delivering its scientific opinion, the EFSA GMO Panel considered the application EFSAGMO- CZ-2006-33, additional informatio...

  4. Is EC class predictable from reaction mechanism?

    OpenAIRE

    Nath Neetika; Mitchell John BO

    2012-01-01

    We thank the Scottish Universities Life Sciences Alliance (SULSA) and the Scottish Overseas Research Student Awards Scheme of the Scottish Funding Council (SFC) for financial support. Background: We investigate the relationships between the EC (Enzyme Commission) class, the associated chemical reaction, and the reaction mechanism by building predictive models using Support Vector Machine (SVM), Random Forest (RF) and k-Nearest Neighbours (kNN). We consider two ways of encoding the reaction...

  5. Preliminary conceptual design of DEMO EC system

    Energy Technology Data Exchange (ETDEWEB)

    Garavaglia, S., E-mail: garavaglia@ifp.cnr.it; Bin, W.; Bruschi, A.; Granucci, G.; Moro, A.; Rispoli, N. [Institute of Plasma Physics “P.Caldirola”, National Research Council of Italy, Milan (Italy); Grossetti, G.; Strauss, D. [IAM-AWP, Kaiserstr. 12, D-76131 Karlsruhe (Germany); Jelonnek, J. [IHM, KIT, Kaiserstr. 12, D-76131 Karlsruhe (Germany); Tran, Q. M. [CRPP, EPFL, EURATOM Association, CH-1015 Lausanne (Switzerland); Franke, T. [EUROfusion Consortium, Boltzmannstr. 2, D-85748 Garching (Germany); Max-Planck-Institut für Plasmaphysik, Garching (Germany)

    2015-12-10

    In the framework of EUROfusion Consortium the Work Package Heating and Current Drive addresses the engineering design and R&D for the electron cyclotron, ion cyclotron and neutral beam systems. This paper reports the activities performed in 2014, focusing on the work done regarding the input for the conceptual design of the EC system, particularly for the gyrotron, the transmission line and the launchers.

  6. Short communication. Growth and nodulation of cowpea after 5 years of consecutive composted tannery sludge amendment

    Directory of Open Access Journals (Sweden)

    Ana R. L. Miranda

    2014-10-01

    Full Text Available Tannery industry releases high amounts of tannery sludge which are currently composted and used in agricultural soils. The consecutive amendment of such composted tannery sludge (CTS may affect soil microrganisms, such as rhizobia. In this study, we evaluated the effects of 5-year repeated CTS amendment on growth, nodulation, and yield of cowpea (Vigna unguiculata L. CTS was applied in different amounts (0, 2.5, 5, 10 and 20 Mg/ha to a sandy soil. Amendment of CTS increased soil pH, electrical conductivity (EC, sodium and chromium content. Plant growth, nodulation, N accumulation, and cowpea yield increased up to 10 Mg/ha; however, above this rate, these variables decreased. After 5 years of CTS amendment, the increase in soil chemical properties, particularly EC and Na content, exerted negative effects on the growth, nodulation, and yield of cowpea.

  7. 77 FR 56913 - Privacy Act of 1974, as Amended

    Science.gov (United States)

    2012-09-14

    ... Circular No. 230. Amendments to the regulations were published recently at 76 FR 32286-32312, June 3, 2011.... A notice describing Treasury/IRS 37.007 was most recently published at 75 FR 64406-64407, October 19... Internal Revenue Service Privacy Act of 1974, as Amended AGENCY: Internal Revenue Service, Treasury....

  8. Is EC class predictable from reaction mechanism?

    Directory of Open Access Journals (Sweden)

    Nath Neetika

    2012-04-01

    Full Text Available Abstract Background We investigate the relationships between the EC (Enzyme Commission class, the associated chemical reaction, and the reaction mechanism by building predictive models using Support Vector Machine (SVM, Random Forest (RF and k-Nearest Neighbours (kNN. We consider two ways of encoding the reaction mechanism in descriptors, and also three approaches that encode only the overall chemical reaction. Both cross-validation and also an external test set are used. Results The three descriptor sets encoding overall chemical transformation perform better than the two descriptions of mechanism. SVM and RF models perform comparably well; kNN is less successful. Oxidoreductases and hydrolases are relatively well predicted by all types of descriptor; isomerases are well predicted by overall reaction descriptors but not by mechanistic ones. Conclusions Our results suggest that pairs of similar enzyme reactions tend to proceed by different mechanisms. Oxidoreductases, hydrolases, and to some extent isomerases and ligases, have clear chemical signatures, making them easier to predict than transferases and lyases. We find evidence that isomerases as a class are notably mechanistically diverse and that their one shared property, of substrate and product being isomers, can arise in various unrelated ways. The performance of the different machine learning algorithms is in line with many cheminformatics applications, with SVM and RF being roughly equally effective. kNN is less successful, given the role that non-local information plays in successful classification. We note also that, despite a lack of clarity in the literature, EC number prediction is not a single problem; the challenge of predicting protein function from available sequence data is quite different from assigning an EC classification from a cheminformatics representation of a reaction.

  9. The German Radiation Protection Ordinance as amended in 2000. The new regulations and their potential to initiate changes in practice. Proceedings

    International Nuclear Information System (INIS)

    The papers presented at the meeting of experts focus on the new regulations of the statutory ordinance on radiation protection (StrlSchV) and the resulting changes in practical implementation, as for instance with respect to occupational exposure and population exposure. All papers of the meeting have been analysed and indexed for separate retrieval from the ENERGY database. (orig./CB)

  10. 77 FR 61721 - Pilot, Flight Instructor, and Pilot School Certification; Technical Amendment

    Science.gov (United States)

    2012-10-11

    ...: The FAA is correcting a final rule; technical amendment published on December 16, 2011 (76 FR 78141... August 21, 2009 (74 FR 42500). In that original final rule, the FAA amended its regulations to revise the... December 16, 2011 (76 FR 78141), the FAA published a final rule; technical amendment. This final...

  11. Encountering Challenges with the EU Regulation on Advance Therapy Medical Products.

    Science.gov (United States)

    Mansnérus, Juli

    2015-12-01

    This article aims at analysing how well the Advanced Therapy Medical Product Regulation (EC) No. 1394/2007 (ATMP Regulation) meets the needs of small and medium-sized enterprises (SMES), academia and public tissue establishments developing advanced therapy medical products (ATMPS). Benefits and shortcomings of the ATMP Regulation are identified, and possible amendments are proposed to accelerate the translation of research into advanced therapies and to facilitate the commercialisation of ATMPS whilst ensuring safety. It was set up as a lex specialis to ensure the free movement of ATMPS within the EU in order to facilitate their access to the internal market and to foster the competitiveness of European pharmaceutical companies, while guaranteeing the highest level protection of public health. Since the adoption of the ATMP Regulation in late 2008, only 5 ATMPS have been granted marketing authorisations thus far. Hence, there is a need to analyse whether the ATMP Regulation meets its objectives. PMID:26665690

  12. Scientific Opinion on the substantiation of a health claim related to Prolibra® and “helps to reduce body fat while preserving lean muscle” pursuant to Article 13(5 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2012-11-01

    Full Text Available Following an application from Glanbia Nutritionals plc, submitted pursuant to Article 13(5 of Regulation (EC No 1924/2006 via the Competent Authority of Ireland, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to Prolibra® and “helps to reduce body fat while preserving lean muscle” in the context of energy restriction for weight loss. Prolibra® was described by the applicant as a partially hydrolysed whey protein isolate containing whey protein, peptides and milk minerals. The applicant denoted the peptides contained in Prolibra® as “weight loss peptides” and claims that these particular peptides contribute to the specificity of Prolibra® in relation to the claimed effect. The Panel notes that, while a specific fraction (i.e. the peptide fraction of Prolibra®, is claimed to play a role on the claimed effect (i.e. “helps to reduce body fat while preserving lean muscle” in the context of energy restriction for weight loss, the information provided by the applicant was insufficient to characterise these peptides and thus the food constituent (i.e. Prolibra® for which the claim is made. The Panel considers that the food, Prolibra®, which is the subject of the health claim, is not sufficiently characterised in relation to the claimed effect. The Panel concludes that a cause and effect relationship cannot be established between the consumption of Prolibra® and “helps to reduce body fat while preserving lean muscle” in the context of energy restriction for weight loss.

  13. 77 FR 49089 - High-Cost Mortgage and Homeownership Counseling Amendments to the Truth in Lending Act...

    Science.gov (United States)

    2012-08-15

    ... Consumer Protection Act (Dodd-Frank Act) amends the Truth in Lending Act by expanding the types of mortgage... Mortgage and Homeownership Counseling Amendments to the Truth in Lending Act (Regulation Z) and... Homeownership Counseling Amendments to the Truth in Lending Act (Regulation Z) and Homeownership...

  14. EC Competition law and environmental protection

    Energy Technology Data Exchange (ETDEWEB)

    Rantala, M.

    1996-12-31

    Due to the increasing attention paid on environmental protection, by the European Community, the Member States and the consumers, undertakings are forced to adjust their policies to meet the new demands posed by public authorities and the market. This has an inevitable impact on competition. No matter how acceptable the goals were, the means are to be assessed also from the competition law point of view. The objective of this study is to analyze the situations where conflicts may take place, the main sources of research being the principles of law relating to the Treaty ,the judgements of the European Court of Justice, the Commission Decisions and other official documents of the Community as well as legal literature. This study classifies the Community and Member State instruments which are used for environmental protection into four categories. These are legislative, market-based, horizontal and financial supporting instruments. Undertakings` environmental practices, which are capable of affecting competition, are examined under Articles 85 and 86 EC, some attention being paid also to Article 90 EC. The touching points of competition policy and environmental protection in such cases are scrutinized under three headings. These are the two, in this case, most relevant public instruments, ie. legislative and market-based measures, and the voluntary actions of undertakings. (42 refs.)

  15. 78 FR 41304 - Navigation and Navigable Waters; Technical, Organizational, and Conforming Amendments; Correction

    Science.gov (United States)

    2013-07-10

    ... of Federal Regulations (78 FR 39163). This rule coincided with the annual recodification of Title 33..., Organizational, and Conforming Amendments; Correction AGENCY: Coast Guard, DHS. ACTION: Final rule;...

  16. 30 CFR 925.16 - Required program amendments.

    Science.gov (United States)

    2010-07-01

    ... regulations at 30 CFR 817.95(a). (5)-(19) (20) At 10 CSR 40-8.070(2)(C)1.A(II)(a) and (b) to revise the... the Federal regulation requirements at 30 CFR 702.5(a)(2)(i) and (ii). (21) (q)-(u) (v) By May 10... amendments. Pursuant to 30 CFR 732.17, Missouri is required to make the following program amendments:...

  17. Amending Death Rules

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    China’s Criminal Law is being revised to cut down on death sentences and tighten up punishment for surging crimes The eighth amendment to the Criminal Law, demanding moreprudent use of capital punishment

  18. Summary of ECE Presentations at EC-18

    Directory of Open Access Journals (Sweden)

    Taylor G.

    2015-01-01

    Full Text Available There were nine ECE and one EBE presentation at EC-18. Four of the presentations were on various aspects of ECE on ITER. The ITER ECE diagnostic has entered an important detailed preliminary design phase and faces several design challenges in the next 2-3 years. Most of the other ECE presentations at the workshop were focused on applications of ECE diagnostics to plasma measurements, rather than improvements in technology, although it was apparent that heterodyne receiver technology continues to improve. CECE, ECE imaging and EBE imaging are increasingly providing valuable insights into plasma behavior that is important to understand if future burning plasma devices, such as ITER, FNSF and DEMO, are to be successful.

  19. 76 FR 61996 - Fishery Management Plan for the Scallop Fishery Off Alaska; Amendment 13

    Science.gov (United States)

    2011-10-06

    ... exceeded; and (6) creates an EC category for non-target scallop species. With adoption of Amendment 13... non-target scallop species occupy habitats at different depths than the targeted weathervane scallops... non-target scallop species are overfished, subject to overfishing or approaching an...

  20. Consumption of food in EC countries

    International Nuclear Information System (INIS)

    Annual consumption of 10 classes of food and drink is reported for the total population of each EC-country. National food consumption data are generalized by distinguishing groups of countries with similar diet. Group 1: UK and Ireland (low consumption of fruit, high consumption of potatoes and fresh dairy products). Group 2: Italy and Greece (high consumption of cereals, vegetables and fruit, low consumption of fresh dairy products). Group 3: France, Belgium, Luxembourg, Netherlands, FRG and Spain (intermediate consumption of most foodstuffs). Portugal and Denmark could not be classified in any group. Changes in food consumption related to differences in age, sex, social class, regional habits and level of urbanisation are reported.In some cases, variation of annual food consumption over the different seasons on the relative contribution of food from local origin to the total diet, could be estimated. Differences of region, age and level of urbanisation appear to have the largest influence on consumed amounts. As for age, the values for the different age-groups range from 50 to 80 percent of the adult diet. Regional consumption may diverge from 70-130 percent of the average national consumption, with values of 200 percent for potatoes and fruit. Consumption in urban areas compared with the entire country diverges from 70-100 percent. In rural areas the values diverge from 100-140 percent. Self-support of vegetables and milk seems to be important for most countries. Of the other products, self-support of wheat and cheese is only of importance in the south of the EC. When combining the effects of the different factors, a range of consumed amounts for specific population groups of 50 to 200 percent of the average national consumption was determined. (author). 38 refs.; 13 figs.; 75 tabs

  1. Real-time multi-EC-actuator MHD control on TCV

    Energy Technology Data Exchange (ETDEWEB)

    Goodman, T. P.; Canal, G.; Duval, B. P.; Graves, J. P.; Kim, D.; Reimerdes, H.; Sauter, O.; Testa, D. [Ecole Polytechnique Fédérale de Lausanne (EPFL), Centre de Recherches en Physique des Plasmas, Association Euratom-Confédération Suisse, CH-1015 Lausanne (Switzerland); Felici, F. [Ecole Polytechnique Fédérale de Lausanne (EPFL), Centre de Recherches en Physique des Plasmas, Association Euratom-Confédération Suisse, CH-1015 Lausanne, Switzerland and Eindhoven University of Technology - Faculty of Mec (Netherlands); Collaboration: TCV Team

    2014-02-12

    Real-time control of multiple plasma actuators is a requirement in advanced tokamaks; for example for burn control, plasma current profile control and MHD stabilization - EC wave absorption is ideally suited especially for the latter. For example, on ITER 24 EC sources can be switched between 54 inputs at the torus. In the torus, 5 launchers direct the power to various locations across the plasma profile via 11 steerable mirrors. For optimal usage of the available power, the aiming and polarization of the beams must be adapted to the plasma configuration and the needs of the scenario. Since the EC system performs many competing tasks, present day systems should demonstrate the ability of an EC plant to deal with several targets in parallel and/or to switch smoothly between goals to attain overall satisfaction. Recently TCV has taken a first step towards such a demonstration. Several EC launchers are used simultaneously to regulate the sawtooth period and to preempt m/n = 3/2 NTMs, by controlling the power levels. In parallel, a second algorithm stabilizes any NTM that saturates [1]. These and real-time MHD control experiments on ELMs [2] are presented.

  2. Austria's environmental law in comparison with the environmental law of the EC

    International Nuclear Information System (INIS)

    The thesis describes and compares the environmental legislation in Austria and the EC. A short introduction into structure and organization of EC-institutions and EC-legislation in followed by an examination of the constitutional foundations of environmental policy in Austria and the EC respectively. After the adoption for the Single European Act, the EEC-Treaty provides for objectives, orientation criteria and instruments regarding environmental protection. These provisions constitute a valid basis for environmental action. The adoption of a constitutional law does equally declare environmental protection as an objective of the state in Austria, however, its significance is regarded as rather controversial. Some provinces ('Laender') have shown a higher degree of sensitivity in their constitutions . The distribution of powers between the EC and its member stated in the field of environmental protection is of particular interests. It is shown, that the principle of subsidiarity and the safeguard-clauses leave discretion to the member states. Much will be determined by the European Court of Justice (ECJ) . Main emphasis has been placed on the description and comparison of Austria's and the EEC-environmental legislation. Environmental legislation of Austria as well as the EC is outlined sector by sector (i.e. water, air, chemicals, waste, soil, fauna and flora) and subsequently the object of a detailed comparison. Criteria, such as - preventiveness -stringency - focus, depth and comprehensiveness - clearness and legal force of the regulations have been applied. For most of the mentioned sectors it is correct to state, that Austria's legislation is more preventive, advanced, comprehensive and stringent (especially regulations related to water, waste, chemicals, also air) . However, there are particular areas (e.g. air quality objectives, noise limits for construction plants) where Austria' s legislation may well get a fresh impetus

  3. The design, manufacture and testing of a new generation of ISO freight container for certification as an IP-2 package in compliance with the IAEA Regulations for the Safe Transport of Radioactive Material -1985 edition (as amended 1990)

    International Nuclear Information System (INIS)

    Solid low level radioactive waste (LLW) which arises at nuclear power stations and other nuclear facilities in the UK, is routinely transported to British Nuclear Fuels site at Drigg in Cumbria for disposal. A requirement was identified for the use of an ISO freight container of the full-height design, to transport drummed LLW to the site of a supercompaction facility prior to disposal at Drigg. This was initially accomplished using refurbished containers incorporating a number of enhanced features. It was recognised that the use of a refurbished container was only an interim measure and as a result of significant changes in the acceptance criteria for disposal, the increased use of high force compaction techniques and the proposed amendments to the IAEA Transport Regulations, Nuclear Electric embarked upon the development of a new generation of ISO freight container. The new design of container, Design No. 2044, incorporates a readily decontaminable stainless steel interior, a comprehensive load restraint system designed for the transport of single and multiple packages, and is lined with a polyurethane foam between the inner and outer skins. It is designed to transport 70 off, 200 litre drums of LLW (stacked in two layers) and other payloads of size not greater than 4 m long x 2 m wide and 20 tonnes in weight. The container was subjected to a range of tests to prove compliance with the ISO standard and the IAEA Transport Regulations. Following the preparation of the required documentation, in particular a Safety Case and comprehensive Operating and Maintenance Instructions, a Certificate of Regulatory Compliance was issued by the appropriate authority certifying the container as an Industrial Package Type 2 (IP-2) suitable for the transport of drummed LLW and other materials within LSA-II/SCO-II limits. (Author)

  4. 41 CFR 101-1.111 - Retention of FPMR amendments.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Retention of FPMR amendments. 101-1.111 Section 101-1.111 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System §...

  5. Analysis of the EC Commission Plan for CAP Reform, An

    OpenAIRE

    Patrick C. Westhoff

    1991-01-01

    The Commission of the European Community has proposed a restructuring of the Common Agricultural Policy (CAP) that is independent of the ongoing General Agreement on Tariffs and Trade (GATT) negotiations. This study analyzes the proposal in terms of the flexibility it would grant EC negotiators at the GATT. The results indicate that adopting the proposal would sharply reduce the volume of EC cereal, meat, and dairy product exports. EC negotiators at the GATT would be able to offer significant...

  6. Royal Order of 11 February 1987 amending the Royal Order of 28 February 1987 laying down General Regulations concerning Protection of the Public and Workers against the Hazards of Ionizing Radiation

    International Nuclear Information System (INIS)

    This Order implements European Community legislation on radiation protection. It refers to the 1980 Community Directive (as amended in 1984) and concerns standards for liquid or gaseous radioactive effluent releases to the environment. (NEA)

  7. Making Electoral Amends

    Institute of Scientific and Technical Information of China (English)

    LI Lin

    2010-01-01

    @@ An amendment to the Electoral Law of the National People's Congress and Local People's Congresses of the People's Republic of China providing equal legislative representation to rural and urban people was ratifled at the closing meeting of the Third Session of the 11th National People's Congress(NPC),China's top legislature,on March 14.Li Lin,Director of the Law Institute of the Chinese Academy of Social Sciences.elaborated on the amendment and outlined its effect on the Chinese people during an interview with Beijing Review reporter Yin Pumin.Some excerpts follow:

  8. EC/β+ decay of 161Er

    International Nuclear Information System (INIS)

    Full text: The study of odd-proton nuclei in rare-earth region has been performed to get more information on the nuclear structure of these nuclei. In the framework of a program at the ISOL complex of YASNAPP-2 at JINR to study the decay of odd-nuclei, 161Er has been investigated. The experiments have been focused on the 161Ho level scheme populated in the EC/β+ decay of 161Er for which a few results have been previously reported [1,2]. Spectra of single γ-ray, γ-γ coincidence and internal conversion electrons were measured. There are appreciable disagreements between results of some γ-ray intensities obtained by us and in [2]. The greatest difference was for relative γ-ray intensity of the 11.28 keV, which has reported value Iγ ∼ 10 (Iγ211=1000) in [2], but this leads to an overpopulation of the 211 keV level by 14% of the decay [3]. The relative intensities of transitions with Eγ γ211=1000). Inaccuracy of Iγ in [2] is probably due to a sudden change in the efficiency curve of their Ge(Li) detector in the low energy region while our HPGe detector feature a much smoother variation in the efficiency curve in this γ-ray energy region. Besides, the levels earlier introduced by us in [4], three new levels in 161Ho were proposed from γ-γ coincidences at energies 693.2 keV, 859.6 keV, and 957.97 keV. Spins, parities and Nilsson quantum characteristics of some 161Ho levels were established

  9. Analyzing 5 years of EC-TEL proceedings

    NARCIS (Netherlands)

    Reinhardt, Wolfgang; Meier, Christian; Drachsler, Hendrik; Sloep, Peter

    2011-01-01

    Reinhardt, W., Meier, C., Drachsler, H., & Sloep, P. B. (2011). Analyzing 5 years of EC-TEL proceedings. In C. D. Kloos, D. Gillet, R. M. Crespo García, F. Wild, & M. Wolpers (Eds.), Towards Ubiquitous Learning: 6th European Conference of Technology Enhanced Learning, EC-TEL 2011 (pp. 531-536). Sept

  10. Amending Death Rules

    Institute of Scientific and Technical Information of China (English)

    LI LI

    2010-01-01

    @@ The eighth amendment to the Criminal Law, demanding more prudent use of capital punishment, has triggered hot debates in China after it was presented to the Standing Committee of the National People's Congress (NPC), China's top legislature, for the first reading at the end of August.

  11. First Amendment Glossary.

    Science.gov (United States)

    Update on Law-Related Education, 1998

    1998-01-01

    Provides a list of terms and the corresponding definitions pertaining to the First Amendment. Focuses on concepts such as, but not limited to, freedom, ratification, separation of church and state, and Constitution that are used in the articles and teaching strategies throughout this issue of "Update on Law-Related Education." (CMK)

  12. 16 CFR 1609.1 - Text of the Flammable Fabrics Act of 1953, as amended in 1954.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Text of the Flammable Fabrics Act of 1953... FLAMMABLE FABRICS ACT REGULATIONS TEXT OF THE FLAMMABLE FABRICS ACT OF 1953, AS AMENDED IN 1954, PRIOR TO 1967 AMENDMENT AND REVISION § 1609.1 Text of the Flammable Fabrics Act of 1953, as amended in 1954....

  13. 78 FR 78165 - List of Approved Spent Fuel Storage Casks: HI-STORM 100 Cask System; Amendment No. 9

    Science.gov (United States)

    2013-12-26

    ... RIN 3150-AJ12 List of Approved Spent Fuel Storage Casks: HI-STORM 100 Cask System; Amendment No. 9... amends the NRC's spent fuel storage regulations by revising the Holtec International HI-STORM 100 Cask System listing within the ``List of Approved Spent Fuel Storage Casks'' to include Amendment No. 9...

  14. Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability*

    Science.gov (United States)

    Patella, Francesca; Schug, Zachary T.; Persi, Erez; Neilson, Lisa J.; Erami, Zahra; Avanzato, Daniele; Maione, Federica; Hernandez-Fernaud, Juan R.; Mackay, Gillian; Zheng, Liang; Reid, Steven; Frezza, Christian; Giraudo, Enrico; Fiorio Pla, Alessandra; Anderson, Kurt; Ruppin, Eytan; Gottlieb, Eyal; Zanivan, Sara

    2015-01-01

    Endothelial cells (ECs) play a key role to maintain the functionality of blood vessels. Altered EC permeability causes severe impairment in vessel stability and is a hallmark of pathologies such as cancer and thrombosis. Integrating label-free quantitative proteomics data into genome-wide metabolic modeling, we built up a model that predicts the metabolic fluxes in ECs when cultured on a tridimensional matrix and organize into a vascular-like network. We discovered how fatty acid oxidation increases when ECs are assembled into a fully formed network that can be disrupted by inhibiting CPT1A, the fatty acid oxidation rate-limiting enzyme. Acute CPT1A inhibition reduces cellular ATP levels and oxygen consumption, which are restored by replenishing the tricarboxylic acid cycle. Remarkably, global phosphoproteomic changes measured upon acute CPT1A inhibition pinpointed altered calcium signaling. Indeed, CPT1A inhibition increases intracellular calcium oscillations. Finally, inhibiting CPT1A induces hyperpermeability in vitro and leakage of blood vessel in vivo, which were restored blocking calcium influx or replenishing the tricarboxylic acid cycle. Fatty acid oxidation emerges as central regulator of endothelial functions and blood vessel stability and druggable pathway to control pathological vascular permeability. PMID:25573745

  15. 75 FR 11231 - Amendments to Regulation SHO

    Science.gov (United States)

    2010-03-10

    ... security.\\33\\ \\32\\ See id. \\33\\ See 2006 Price Test Elimination Proposing Release, 71 FR at 75069-75070....C. 78j(a). \\39\\ See id.; see also 2006 Price Test Elimination Proposing Release, 71 FR at 75068... restrictions in existence at that time. \\62\\ See 2006 Price Test Elimination Proposing Release, 71 FR at...

  16. 7 CFR 983.75 - Implementation and amendments.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Implementation and amendments. 983.75 Section 983.75 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing..., upon the recommendation of a majority of the committee, may issue rules and regulations implementing...

  17. Expression of a finger millet transcription factor, EcNAC1, in tobacco confers abiotic stress-tolerance.

    Directory of Open Access Journals (Sweden)

    Venkategowda Ramegowda

    Full Text Available NAC (NAM, ATAF1-2, and CUC2 proteins constitute one of the largest families of plant-specific transcription factors and have been shown to be involved in diverse plant processes including plant growth, development, and stress-tolerance. In this study, a stress-responsive NAC gene, EcNAC1, was isolated from the subtracted stress cDNA library generated from a drought adapted crop, finger millet, and characterized for its role in stress-tolerance. The expression analysis showed that EcNAC1 was highly induced during water-deficit and salt stress. EcNAC1 shares high amino acid similarity with rice genes that have been phylogenetically classified into stress-related NAC genes. Our results demonstrated that tobacco transgenic plants expressing EcNAC1 exhibit tolerance to various abiotic stresses like simulated osmotic stress, by polyethylene glycol (PEG and mannitol, and salinity stress. The transgenic plants also showed enhanced tolerance to methyl-viologen (MV induced oxidative stress. Reduced levels of reactive oxygen species (ROS and ROS-induced damage were noticed in pot grown transgenic lines under water-deficit and natural high light conditions. Root growth under stress and recovery growth after stress alleviation was more in transgenic plants. Many stress-responsive genes were found to be up-regulated in transgenic lines expressing EcNAC1. Our results suggest that EcNAC1 overexpression confers tolerance against abiotic stress in susceptible species, tobacco.

  18. The contribution of the amended Renewables Act (EEG) to the intended energy transition; Der Beitrag der Novelle des Erneuerbare-Energien-Gesetzes (EEG) zur Energiewende

    Energy Technology Data Exchange (ETDEWEB)

    Salje, Peter

    2012-07-01

    Compared with the amendment fo 2009, the new amendment has 21 new sections, which makes a total of 87 sections and five attachments, plus four ordinances. The author discusses some of the new regulations. (orig./AKB)

  19. Risk assesment in the context of EC directives on genetically modified organisms

    International Nuclear Information System (INIS)

    The introduction of these new molecular technologies initiated an international discussion on the safety in biotechnology. In 1974 one of the pioneers of this new technology, Paul Berg, expressed his view on the potential risks of recombinant DNA applications in the famous 'Berg letter', leading to a self-imposed moratorium on certain experiments. Following the Berg letter and the Asilomar convention, much international attention has been given to the question of safety in biotechnology. This attention resulted in hundreds of documents, research programmes, guidelines and regulations. This resulted, among others, in two EC Directives on genetically modified organisms: the EC Directive 90/219/EEC on the contained use of genetically modified micro-organisms, and Directive 90/220/EEC on the release of genetically modified organisms. These directives lay down a system for harmonization of risk assessment and risk management with regard to the safety for human health and the environment

  20. Electronic Project of Taxation Based on EC Under Single Nation

    Institute of Scientific and Technical Information of China (English)

    WANG Tao; ZENG Xiao-ping

    2002-01-01

    Because of no real location and its virtual interaction, the information flow, the cash flow and the logistic flow of EC(Electronic Commerce) are to be separated individually. So the traditional taxation based on those three flows is challenged. Under this condition, this paper researches how to levy taxes on EC through internet using internet technology. As to simplify the model, it relates under a single nation. But it will also give some measures about the international trades.

  1. Cloning and Expression Analysis of One Gamma-Glutamylcysteine Synthetase Gene (Hbγ-ECS1) in Latex Production in Hevea brasiliensis.

    Science.gov (United States)

    Fang, Wei; Qiao, Luo Shi; Ming, Wu; Jian, Qiu; Feng, Yang Wen; Hua, Gao Hong; Zhou, Xiao Xian

    2016-01-01

    Rubber tree is a major commercial source of natural rubber. Latex coagulation is delayed by thiols, which belong to the important type of antioxidants in laticifer submembrane, and is composed of glutathione (GSH), cysteine, and methionine. The rate-limiting enzyme, γ-ECS, plays an important role in regulating the biosynthesis of glutathione under any environment conditions. To understand the relation between γ-ECS and thiols and to correlate latex flow with one-time tapping and continuous tapping, we cloned and derived the full length of one γ-ECS from rubber tree latex (Hbγ-ECS1). According to qPCR analysis, the expression levels of Hbγ-ECS1 were induced by tapping and Ethrel stimulation, and the expression was related to thiols content in the latex. Continuous tapping induced injury, and the expression of HbγECS1 increased with routine tapping and Ethrel-stimulation tapping (more intensive tapping). According to expression in long-term flowing latex, the gene was related to the duration of latex flow. HbγECS1 was expressed in E. coli Rosetta using pET-sumo as an expression vector and the recombinant enzyme was purified; then we achieved 0.827 U/mg specific activity and about 66 kDa molecular weight. The present study can help us understand the complex role of Hbγ-ECS in thiols biosynthesis, which is influenced by tapping. PMID:27419133

  2. Optimization of the EC Heating and Current Drive Capabilities

    International Nuclear Information System (INIS)

    Full text: A 24 MW CW Electron Cyclotron Heating and Current Drive (EC H&CD) system operating at 170 GHz is to be installed for the ITER tokamak. The ITER EC system will represent a large step forward in the use of microwave systems for plasma heating and current drive applications. Present day systems are operating in relatively short pulses (≤ 10 s) and installed power levels of ≤ 4.5 MW, while the ITER EC system parameters are CW operation and 20 MW injected power. The technical challenge facing the development and installation of the EC system is further complicated due to the harsh ITER in-vessel environment and complicated procurement strategy. The ITER EC international community has confronted these challenges, aiming at integrating the modifications proposed from the 2007 ITER design review and further enhancing the EC system capabilities. These changes have not only simplified the technical design, but have also simplified the procurement interfaces and increased the functional capabilities for plasma heating and current drive applications. The functional improvements include increasing the access of the EC power from ∼ 50% to nearly ∼ 90% of the plasma cross section. In particular the UL has been modified to allow power deposition over the range of ∼ 0.3 ≤ ρΤ ≤ 0.9 compared to previous access of ∼ 0.55 ≤ ρΤ ≤ 0.85 (where ρΤ is the square root of the normalized toroidal flux). This allows the UL to be applicable for a broader access for stabilization of neoclassical tearing modes (NTMs) and sawtooth instability. The EC heating is functionally limited in magnetic field region depending on the resonant harmonic. The heating access in ITER was assumed to be applicable over ∼ 33% of the range from 2.3 T to 5.3 T, regions of fundamental and second harmonics. Recent analysis associated with the EL has demonstrated that the EC system is applicable over a much broader range: ∼ 75% for central heating (ρΤ ≤ 0.5) and ∼ 90% for L

  3. Amending Contracts for Choreographies

    CERN Document Server

    Bocchi, Laura; Tuosto, Emilio; 10.4204/EPTCS.59.10

    2011-01-01

    Distributed interactions can be suitably designed in terms of choreographies. Such abstractions can be thought of as global descriptions of the coordination of several distributed parties. Global assertions define contracts for choreographies by annotating multiparty session types with logical formulae to validate the content of the exchanged messages. The introduction of such constraints is a critical design issue as it may be hard to specify contracts that allow each party to be able to progress without violating the contract. In this paper, we propose three methods that automatically correct inconsistent global assertions. The methods are compared by discussing their applicability and the relationships between the amended global assertions and the original (inconsistent) ones.

  4. 77 FR 10547 - Kickapoo Traditional Tribe of Texas-First Amended Beer and Liquor Tax Ordinance

    Science.gov (United States)

    2012-02-22

    ... Bureau of Indian Affairs Kickapoo Traditional Tribe of Texas--First Amended Beer and Liquor Tax Ordinance... to the Kickapoo Traditional Tribe of Texas' Beer and Liquor Tax Ordinance. The Ordinance regulates... adopted this amendment to the Kickapoo Traditional Tribe of Texas' Beer and Liquor Tax Ordinance...

  5. 77 FR 23598 - Technical Amendment to Cuba Airport List: Addition of Recently Approved Airports

    Science.gov (United States)

    2012-04-20

    ... FR 5058) that amended the CBP regulations to establish such procedures and airport eligibility... SECURITY U.S. Customs and Border Protection 19 CFR Part 122 Technical Amendment to Cuba Airport List... from Cuba. DATES: Effective: April 20, 2012. FOR FURTHER INFORMATION CONTACT: Arthur A.E. Pitts, Sr.,...

  6. 76 FR 76612 - Amendments to OMB Control Numbers and Certain Forms

    Science.gov (United States)

    2011-12-08

    ... Minerals Revenue Management Program (MRM) the Office of Natural Resources Revenue (ONRR) and directed that...-- Minerals Revenue Management. These amendments to the regulations are explained further in the following...--Suspensions Pending Appeal and Bonding--Minerals Revenue Management 1. We are amending the title of part...

  7. 76 FR 31831 - Navigation and Navigable Waters; Technical, Organizational, and Conforming Amendments

    Science.gov (United States)

    2011-06-02

    ... Conforming Amendments AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: This rule makes non-substantive... conforming amendments and technical corrections to Coast Guard navigation and navigable water regulations.... 553(b)(B) as this rule consists only of corrections and editorial, organizational, and...

  8. Draft Mission Plan Amendment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-09-01

    The Department of Energy`s Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation`s spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs.

  9. Draft Mission Plan Amendment

    International Nuclear Information System (INIS)

    The Department of Energy's Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation's spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs

  10. Swedish healthcare providers' perceptions of preconception expanded carrier screening (ECS)-a qualitative study.

    Science.gov (United States)

    Matar, A; Kihlbom, U; Höglund, A T

    2016-07-01

    Reproductive autonomy, medicalization, and discrimination against disabled and parental responsibility are the main ongoing ethical debates concerning reproductive genetic screening. To examine Swedish healthcare professionals' views on preconception expanded carrier screening (ECS), a qualitative study involving academic and clinical institutions in Sweden was conducted in September 2014 to February 2015. Eleven healthcare professionals including clinicians, geneticists, a midwife, and a genetic counselor were interviewed in depth using a semi-structured interview guide. The questionnaire was constructed after reviewing the main literature and meetings with relevant healthcare providers. The interviews were recorded, transcribed verbatim, and content analyzed for categories and subcategories. Participants nurtured many ethical and non-ethical concerns regarding preconception ECS. Among the ethical concerns were the potential for discrimination, medicalization, concerns with prioritization of healthcare resources, and effects on reproductive freedom. The effects of implementation of preconception ECS, its stakeholders, regulations, and motivation are some of non-ethical concerns. These concerns, if not addressed, may affect the uptake and usage of carrier screening within Swedish healthcare system. As this is a qualitative study with a small non-random sample size, the findings cannot be generalized. The participants had little to no working experience with expanded screening panels. Moreover, the interviews were conducted in English, a second language for the participants, which might have limited the expression of their views. However, the authors claim that the findings may be pertinent to similar settings in other Scandinavian countries. PMID:27225888

  11. 17 CFR 242.608 - Filing and amendment of national market system plans.

    Science.gov (United States)

    2010-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation Nms-Regulation of the National Market System § 242.608 Filing and amendment of... Regulation NMS and part 240, subpart A of this chapter shall, in addition to compliance with this...

  12. 78 FR 18233 - Medical Devices; Technical Amendment

    Science.gov (United States)

    2013-03-26

    ...). These amendments are merely correcting nonsubstantive errors. FDA therefore, for good cause, finds under... heartbeats in patients following cardiac surgery or a myocardial infarction. * * * * * * * * 0 4. Amend...

  13. Fast breeders role in the energy supply of the EC

    International Nuclear Information System (INIS)

    The investigation summarized in this article was initiated by a work team of the International Society of Power Generators (UNIPEDE) and the EC-commission. The first part presents the results of the possible introduction of fast breeder reactors in the EC for power generation and describes its effects on the demand for natural uranium. The second part describes the present development level of reprocessing of breeder reactor fuel, a part of the fuel cycle which is of very special importance. With the assumption of a rather undisturbed utilization of nuclear energy the investigation comes to the result that the development of the fast breeders and their fuel cycle in the EC must be promoted in any case. And, in the future, the available means should be used for a balanced development of both the reactor system and the fuel cycle. (orig.)

  14. Accelerator-Driven Systems - the iThEC strategy

    International Nuclear Information System (INIS)

    The International Thorium Energy Committee (iThEC) created in Geneva in 2012 is concerned about the energetic future of our society, which is totally organized on the basis of a fossil fuel economy. This has to change because of obvious geopolitical reasons, because of the impact this economy has on the environment, and because of the rather short time on the human time scale, it will take for fossil fuels to run out. One of the main goals of iThEC is to work on reversing the current negative perception of nuclear energy in Europe, which is the main hurdle to a more serious R and D effort in this field. iThEC provides better information to the public on thorium possibilities, supports thorium ADS technology developments, any R and D regarding thorium, and actively engages the scientific, political and business leadership on the subject

  15. ECS: Efficient Communication Scheduling for Underwater Sensor Networks

    Directory of Open Access Journals (Sweden)

    Lu Hong

    2011-03-01

    Full Text Available TDMA protocols have attracted a lot of attention for underwater acoustic sensor networks (UWSNs, because of the unique characteristics of acoustic signal propagation such as great energy consumption in transmission, long propagation delay and long communication range. Previous TDMA protocols all allocated transmission time to nodes based on discrete time slots. This paper proposes an efficient continuous time scheduling TDMA protocol (ECS for UWSNs, including the continuous time based and sender oriented conflict analysis model, the transmission moment allocation algorithm and the distributed topology maintenance algorithm. Simulation results confirm that ECS improves network throughput by 20% on average, compared to existing MAC protocols.

  16. ECS: efficient communication scheduling for underwater sensor networks.

    Science.gov (United States)

    Hong, Lu; Hong, Feng; Guo, Zhongwen; Li, Zhengbao

    2011-01-01

    TDMA protocols have attracted a lot of attention for underwater acoustic sensor networks (UWSNs), because of the unique characteristics of acoustic signal propagation such as great energy consumption in transmission, long propagation delay and long communication range. Previous TDMA protocols all allocated transmission time to nodes based on discrete time slots. This paper proposes an efficient continuous time scheduling TDMA protocol (ECS) for UWSNs, including the continuous time based and sender oriented conflict analysis model, the transmission moment allocation algorithm and the distributed topology maintenance algorithm. Simulation results confirm that ECS improves network throughput by 20% on average, compared to existing MAC protocols.

  17. The Financial Regulations of the Agency

    International Nuclear Information System (INIS)

    For ease of comparison and reference, Attachment I shows the full texts of the relevant Regulations in the original form, incorporating all amendments approved by the Board of Governors until 8 June 1999, and in its amended form, after all the above mentioned approved changes. The full text of the Financial Regulations of the Agency, as approved and amended by the Board of Governors up to 11 June 2010, is reproduced in Attachment II for the information of all Members of the Agency

  18. Amending Contracts for Choreographies

    Directory of Open Access Journals (Sweden)

    Laura Bocchi

    2011-07-01

    Full Text Available Distributed interactions can be suitably designed in terms of choreographies. Such abstractions can be thought of as global descriptions of the coordination of several distributed parties. Global assertions define contracts for choreographies by annotating multiparty session types with logical formulae to validate the content of the exchanged messages. The introduction of such constraints is a critical design issue as it may be hard to specify contracts that allow each party to be able to progress without violating the contract. In this paper, we propose three methods that automatically correct inconsistent global assertions. The methods are compared by discussing their applicability and the relationships between the amended global assertions and the original (inconsistent ones.

  19. 78 FR 14664 - Food and Color Additives; Technical Amendments

    Science.gov (United States)

    2013-03-07

    ... and Color Additives; Technical Amendments AGENCY: Food and Drug Administration, HHS. ACTION: Final... regulations regarding food and color additives to correct minor errors (such as misspelled chemical names) and... Subjects 21 CFR Part 73 Color additives, Cosmetics, Drugs, Medical devices. 21 CFR Part 172 Food...

  20. 22 CFR 123.25 - Amendments to licenses.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Amendments to licenses. 123.25 Section 123.25 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT OF...; and change of foreign intermediate consignee if that party is only transporting the equipment and...

  1. Evaluation and selection of soil amendments for field testing to reduce P losses

    Energy Technology Data Exchange (ETDEWEB)

    O' Connor, G.A.; Brinton, S.; Silveira, M.L. [University of Florida, Gainesville, FL (United States). Dept. of Soil & Water Science

    2005-07-01

    The effectiveness of chemical amendments in reducing P losses from manure impacted Florida soil was evaluated using a variety of protocols, including total elemental analysis, short-term laboratory equilibrations, column leaching experiments, and simulated rainfall studies. Amendments used included: two Fe-humates (a Fe-water treatment residual (WTR) and a titanium-mine waste), two Al-WTRs, one Ca-WTR, a coal combustion slag, a Si-rich material (Pro-Sil), a Leonardite material (dinoSoil), and two agricultural materials (lime and gypsum). In equilibration studies, Al-WTRs were the most effective at sorbing P, while Fe-humate sorbed the least P of all treatments. Other amendments effectively reduced soluble P, but increased suspension pH and electrical conductivity (EC) to an extent expected to adversely affect plant growth. Gypsum was the most effective amendment in reducing P leaching in small column studies. DinoSoil treatment significantly altered the soil hydraulic properties, yielding the greatest runoff volumes in a simulated rainfall study. Total P loss (runoff + leachate) was largely determined by the leaching component, and was essentially all soluble reactive phosphorus (SRP) for both bare and grassed soil surfaces. AD treatments reduced runoff SRP compared to the control. Amendment effects in the grassed rainfall study (dominated by leaching) were inconsistent with results from the small column leaching study, possibly due to the different hydraulic conditions and kinetic factors involved in the two studies. The Al-WTRs amendments were recommended for field evaluation.

  2. Achievements and bottlenecks in humanitarian demining EU-funded research: final results from the EC DELVE project

    Science.gov (United States)

    Sahli, Hichem; Bruschini, Claudio; Van Kempen, Luc; Schleijpen, Ric; den Breejen, Eric

    2008-04-01

    The EC DELVE Support Action project has analyzed the bottlenecks in the transfer of Humanitarian Demining (HD) technology from technology development to the use in the field, and drawn some lessons learned, basing itself on the assessment of the European Humanitarian Demining Research and Technology Development (RTD) situation from early 1990 until 2006. The situation at the European level was analyzed with emphasis on activities sponsored by the European Commission (EC). This was also done for four European countries and Japan, with emphasis on national activities. The developments in HD during the last 10 years underline the fact that in a number of cases demining related developments have been terminated or at least put on hold. The study also showed that the funding provided by the EC under the Framework Program for RTD has led directly to the creation of an extensive portfolio of Humanitarian Demining technology development projects. The latter provided a range of research and supporting measures addressing the critical issues identified as a result of the regulatory policies developed in the field of Humanitarian Demining over the last ten years. However, the range of instruments available to the EC to finance the necessary research and development were limited, to pre-competitive research. The EC had no tools or programs to directly fund actual product development. As a first consequence, the EC funding program for development of technology for Humanitarian Demining unfortunately proved to be largely unsuitable for the small-scale development needed in a field where there is only a very limited market. As a second consequence, most of the research has been demonstrator-oriented. Moreover, the timeframe for RTD in Humanitarian Demining has not been sufficiently synchronized with the timeframe of the EC policies and regulations. The separation of the Mine Action and RTD funding streams in the EC did also negatively affect the take-up of new technologies. As a

  3. Scientific Opinion on the substantiation of a health claim related to the combination of artichoke leaf dry extract standardised in caffeoylquinic acids, monacolin K in red yeast rice, sugar-cane derived policosanols, OPC from French maritime pine bark, garlic dry extract standardised in allicin, d-α-tocopheryl hydrogen succinate, riboflavin and inositol hexanicotinate in Limicol® and reduction of blood LDL-cholesterol concentrations pursuant to Article 14 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA

    2013-07-01

    Full Text Available Following an application from Laboratoire Lescuyer, submitted pursuant to Article 14 of Regulation (EC No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to deliver an opinion on the scientific substantiation of a health claim related to the combination of artichoke leaf dry extract standardised in caffeoylquinic acids, monacolin K in red yeast rice, sugar-cane derived policosanols, OPC from French maritime pine bark, garlic dry extract standardised in allicin, d-α-tocopheryl hydrogen succinate, riboflavin and inositol hexanicotinate in Limicol® and reduction of blood LDL-cholesterol concentrations. The Panel considers that the food which is the subject of the claim is sufficiently characterised. The Panel considers that reduction of blood LDL-cholesterol concentrations is a beneficial physiological effect. High LDL-cholesterol is a risk factor in the development of coronary heart disease. In weighing the evidence, the Panel took into account that, although no evidence was provided for an LDL-cholesterol lowering effect of any of the single food constituents in Limicol® at the proposed conditions of use or as to how the ingredients individually or in any combination could contribute to the claimed effect and despite the lack of a dose-response relationship observed in one human intervention study, three human intervention studies conducted by two independent research groups showed an effect of the combination of food ingredients in Limicol® on blood LDL-cholesterol concentrations. The Panel concludes that a cause and effect relationship has been established between the consumption of the combination of artichoke leaf dry extract standardised in caffeoylquinic acids, monacolin K in red yeast rice, sugar-cane derived policosanols, OPC from French maritime pine bark, garlic dry extract standardised in allicin, d-α-tocopheryl hydrogen succinate, riboflavin and inositol

  4. 17 CFR 230.478 - Powers to amend or withdraw registration statement.

    Science.gov (United States)

    2010-04-01

    ... 8(b) of the act, waiving notice and hearing, such order being entered without prejudice to the right... COMMISSION GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 Amendments; Withdrawals § 230.478 Powers...

  5. 877-Royal Decree 1753/1987 of 25 November partly amending the Regulations on health protection against ionizing radiation, approved by Royal Decree 2519/1982 of 12 August

    International Nuclear Information System (INIS)

    This Decree modifies the 1982 Royal Decree on Radiation Protection as a result of Spain's entry into the European Community and its taking into account of EURATOM Radiation Protection Directives 80/836. The 1987 Decree amends relevant provisions of the 1982 Decree to reflect the basic safety standards of the EURATOM Directives concerning the types of activities which imply exposure, the justification and optimisation of exposure and the requirement that individual doses not exceed specified limits. The annual dose equivalent limits are set out in Annex II to the Decree while Annex III gives the annual limits of intake by inhalation and ingestion for workers and members of the public

  6. Renaturation of recombinant human EC-SOD inclusion bodies%重组人EC-SOD包涵体的复性

    Institute of Scientific and Technical Information of China (English)

    朱希强; 袁勤生

    2005-01-01

    目的将E.coli中表达的人胞外超氧化物歧化酶(hEC-SOD)包涵体进行复性.方法分离包涵体,用8mol/L尿素溶解后进行透析复性.结果包涵体蛋白可以部分复性,比活达到900U/mg protein.结论透析复性法可以复性EC-SOD包涵体.

  7. EC-LEDS Mexico: Advancing Clean Energy Goals

    Energy Technology Data Exchange (ETDEWEB)

    2016-07-01

    EC-LEDS works with the government of Mexico to help meet its goals of reducing greenhouse gas emissions from the energy sector. The program targets specific, highly technical areas where Mexico has indicated the program can add value and make an impact.

  8. EC-CERN Memorandum of Understanding (MoU) signature

    CERN Multimedia

    EC audiovisual service

    2009-01-01

    Signature of the Memorandum of Understanding EC-CERN at Brussels with Mr. José Manuel Silva Rodriguez, European Commission Director General for Research , Rolf Heuer, CERN’s Director-General and Torsten Akesson, President of the CERN Council

  9. EC-LEDS Supports the Low-Carbon Transition

    Energy Technology Data Exchange (ETDEWEB)

    2016-09-01

    EC-LEDS is a flagship U.S. government-led effort that assists countries to create and implement low emission development strategies, or LEDS -- development frameworks that promote sustainable social and economic development while reducing greenhouse gas emissions over the medium to long term.

  10. The E-C Translation of Vocabularies in Sports News

    Institute of Scientific and Technical Information of China (English)

    何琳琳

    2014-01-01

    In recent years, many world top level sports events take place in China. The exchange in sports field between China and international society adds more significance to the E-C translation of sports news. This paper analyses the lexical features of sports news and then explains some difficulties in the translation of the words of sports news.

  11. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease.

    Science.gov (United States)

    Edsbäcker, Staffan; Andersson, Tommy

    2004-01-01

    This overview summarises available pharmacokinetic data on budesonide capsules (Entocort EC), approved for the treatment of mild-to-moderate active Crohn's disease involving the ileum and/or ascending colon and for prolongation of symptom control. Budesonide is a locally-acting glucocorticosteroid with an extensive, primarily hepatic, metabolism after oral administration. It is rapidly absorbed and biotransformed by cytochrome P450 (CYP) 3A to metabolites with negligible glucocorticoid activity. Entocort EC, a pH- and time-dependent oral formulation of budesonide, was developed to optimise drug delivery to the ileum and throughout the colon. Pharmaco-scintigraphic studies have confirmed that the Entocort EC formulation delays budesonide absorption and prolongs the rate of elimination but maintains complete absorption. This improves the delivery of budesonide to the intestinal lumen relative to a plain formulation. A low systemic availability of 9-21% indicates extensive first-pass elimination. Food appears to have little impact on the absorption of budesonide from Entocort EC capsules and the pharmacokinetics are dose-proportional between 3 and 15 mg. On average, systemic availability was 2.5-fold higher in patients with cirrhosis compared with healthy controls; however, mild liver impairment had little effect on systemic exposure. Pharmacokinetics appear unaffected by gender and age, although this has not been tested in younger children. Renal impairment is not expected to have an impact on the kinetics of Entocort EC. Budesonide is unlikely to inhibit the metabolism of other drugs, including CYP3A4 substrates, mainly because of the very low plasma concentrations obtained with the compound even after high doses of Entocort trade mark EC capsules. Strong CYP3A4 inhibitors, such as ketoconazole, will inhibit the metabolism of budesonide, resulting in several-fold increases in the area under the concentration-time curve of budesonide. Also, grapefruit juice intake

  12. Chemical characterization of emissions from modern two-stroke mopeds complying with legislative regulation in Europe (EURO-2).

    Science.gov (United States)

    Adam, T; Farfaletti, A; Montero, L; Martini, G; Manfredi, U; Larsen, B; Santi, G De; Krasenbrink, A; Astorga, C

    2010-01-01

    In view of a new amendment to the European legislative regulation on emissions from two-stroke mopeds a study was carried out to comprehensively characterize exhaust gases of mopeds complying current EURO-2 emission standards. Three mopeds with different engine types (carburetor, direct injection, and electronic carburetion system ECS) where investigated by applying two different driving cycles, the legislative cycle ECE47 and the worldwide motorcycle test cycle WMTC. Thereby, particulate matter (PM), regulated compounds, carbonyls, volatile hydrocarbons (VOC), and particle-associated polyaromatic hydrocarbons (PAH) were analyzed and ozone formation potentials (OFP) as well as toxicity equivalents (TEQ) determined. The ECE47 emission factors for almost all species and moped types were much higher in the nonregulated, prior cold phase than in the hot phase, which is considered for legislation. Great differences for the mopeds could be observed for NO(x), VOC, and PM, whereas discrepancies between the driving cycles ECE47 and WMTC were smaller. In addition, a positive influence on exhaust composition caused by technical modifications of the ECS engine was determined. Results indicate that regulation of total hydrocarbons (THC) alone might not be sufficient to regulate PM, especially for direct injection engines. Moreover, recommendations for a revised future test protocol are demonstrated and discussed, whereby the cold phase and the hot phase are taken into account.

  13. Evaluation of the size segregation of elemental carbon (EC) emission in Europe: Influence on the simulation of EC long-range transportation

    NARCIS (Netherlands)

    Chen, Y.; Cheng, Y.F.; Nordmann, S.; Birmili, W.; Denier Van Der Gon, H.A.C.; Ma, N.; Wolke, R.; Wehner, B.; Sun, J.; Spindler, G.; Mu, Q.; Pöschl, U.; Su, H.; Wiedensohler, A.

    2016-01-01

    Elemental Carbon (EC) has a significant impact on human health and climate change. In order to evaluate the size segregation of EC emission in the EUCAARI inventory and investigate its influence on the simulation of EC long-range transportation in Europe, we used the fully coupled online Weather Res

  14. Extracellular superoxide dismutase (SOD3): Tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene

    Energy Technology Data Exchange (ETDEWEB)

    Folz, R.J.; Crapo, J.D. [Duke Univ. Medical Center, Durham, NC (United States)

    1994-07-01

    The authors have isolated and characterized over 10,000 bp of the human EC SOD gene (SOD3 or EC 1.15.1.1) and its 5{prime}- and 3{prime}-flanking regions. Human genomic Southern blot analysis supports the existence of a single gene, without evidence for pseudogenes. The human EC SOD gene spans approximately 5900 bp. The gene can be divided into 3 exons and 2 introns. The 720-bp coding region is uninterrupted and located within exon 3. The 560 bp 5{prime} to the transcription start site were sequenced. No obvious TATA box was identified. A variety of conserved cis elements were identified by database searching. Exon 3 is surrounded by an Alu-J repetitive element in reverse orientation at the 5{prime} and by an Alu-Sx repetitive element in the 3{prime}-flanking DNA. The relative levels of EC SOD tissue-specific expression were determined by RNA gel blot analysis. Adult heart, placenta, pancreas, and lung had the most expression, followed by kidney, skeletal muscle, and liver. Little EC SOD message was found in the brain. A second unique mRNA, approximately 4.2 kb in length, was highly expressed in skeletal muscle. When tissue enzyme activity is compared to relative mRNA levels, there is a marked disparity in the brain, pancreas, and lung, suggesting that these tissues have enhanced affinity for circulating EC SOD or translate the EC SOD message more efficiently than other tissues. These results indicate that the EC SOD gene contains unique transcriptional regulatory elements and that its expression may be regulated at the post-transcriptional or post-translational level. The characterization of the human EC SOD gene should now allow the development of further insights into its biology and provide the basis for studies of its role in human heritable disorders. 68 refs., 5 figs., 1 tab.

  15. 77 FR 11191 - Insurance Cost Information Regulation

    Science.gov (United States)

    2012-02-24

    ..., 58 FR 12545, NHTSA amended 49 CFR part 582, Insurance Cost Information Regulation, to require all... National Highway Traffic Safety Administration Insurance Cost Information Regulation AGENCY: National... insurance cost information booklet that all car dealers must make available to prospective...

  16. Principles for shaping working conditions according to ILO conventions and EC directives.

    Science.gov (United States)

    Koradecka, D

    2001-01-01

    The strategy for the improvement of occupational safety and health is presented. The role of the state and the workers in shaping working conditions has changed over the years, and this process is traced through ILO and EC documents. There must be a coherent up-to-date national policy in this field. Safety and the protection of the workers' health is perceived by the Community legislation not only in the terms of the worker's individual interest, but also from a social viewpoint, consisted in striving for general improvement of the work environment. The Community regulations aspire to satisfy the public interest, and directives set the maximum level of protection but also serve as minimum standards not infringing the more favourable national regulations. They define requirements that should already be met at the planning and designing stages.

  17. Amendment of the Atomic Law. Need of aopproval according to the Constitutional Law and EU competencies for the regulation of the nuclear safety; Novellierung des Atomgesetzes. Zustimmungsbeduerftigkeit nach dem GG und EU-Kompetenzen zur Regelung der nuklearen Sicherheit

    Energy Technology Data Exchange (ETDEWEB)

    Frenz, Walter; Ehlenz, Christian [RWTH Aachen (Germany)

    2010-12-15

    The in the context of the European Atomic Energy Community (Euratom) issued for the dumping of waste disposals and for the safe disposal of radioactive wastes planned secondary legislation concerns to the nuclear safety. The scope of competence is reduced in this range. For the amendment of the atomic law, also covering the extension of power plant operation, essentially substantial points of contact exist, and an independent field of problem develops. This happens in addition to anyway disputed demand of agreement of the Federal Council for the change of the Atomic Energy Act according to Sect. 87c Constitutional Law also having a European legal determinant. The last question did not dominate by the fact that the legal committee of the Federal Council in its meeting at 10th November, 2010, voted by majority that the atomic novella for the extension of power plant operation is obligated for agreement. However, this vote is not binding for the plenum.

  18. EC,ASMC and Macrophage Oxidize Human Low Density Lipoprotein

    Institute of Scientific and Technical Information of China (English)

    Dai Zhao-ming; Wu Jun-zhu; Li Xiao-ming; Chen Li-da; Hong Jia-ling

    2003-01-01

    To investigate the mechanism of LDL oxidation in vivo , LDL was incubated with endothelium cell (EC),artery smooth muscle cell (ASMC) and macrophage, and then the change of myeloperoxidase (MPO) activity in cell and medium and the oxidation of LDL by those three cells were assessed. The result showed that LDL promoted the activity of cellular and secretive myeloperoxidase which was concentration-dependent on LDL; with elevation of MPO activity, oxidation of LDL intensified, which was expressed by the formation of conjugated dienes and the elevation of thiobarbituric acid teactive substance (TBARS). Macrophage's MPO activity went up with the increase of LDL at both low and high concentration; EC's MPO activity went up with the increase of LDL only at high concentration and ASMC's MPO activity wasn't sensitive to LDL concentration change. The results suggest that Macrophage might be crucial to the oxidation of LDL in vivo, in which MPO might play an important role.

  19. EC,ASMC and Macrophage Oxidize Human Low Density Lipoprotein

    Institute of Scientific and Technical Information of China (English)

    Dai; Zhao-ming; Wu; Jun-zhu; 等

    2003-01-01

    To investigate the mechanism of LDL oxidation in vivo, LDL was incubated with endothelium cell (EC),artery smooth muscle cell (ASMC) and macrophage, and then the change of myeloperoxidase (MPO) activity in cell and medium and the oxidation of LDL by those three cells were assessed. The result showed that LDL promoted the activity of cellular and secretive myeloperoxidase which was concentration-dependent on LDL; with elevation of MPO activity, oxidation of LDL intensified, which was expressed by the formation of conjugated dienes and the elevation of thiobarbituric acid teactive substance (TBARS). Macrophage's MPO activity went up with the increase of LDL at both low and high concentration; EC's MPO activity went up with the increase of LDL only at high concentration and ASMC's MPO activity wasn't sensitive to LDL concentration change. The results LDL in vivo, in which MPO might play an important role.

  20. Nanoscale Bio-Molecular Control Using EC-OWLS

    Energy Technology Data Exchange (ETDEWEB)

    Bearinger, J P; Voros, J; Hubbell, J A; Textor, M

    2002-11-20

    A recently developed technique termed ''Electrochemical Optical Waveguide Lightmode Spectroscopy'' (EC-OWLS) [1] combines evanescent-field optical sensing with electrochemical control of surface adsorption processes. Initial EC-OWLS investigations efficiently monitored molecular surface adsorption and layer thickness changes of an adsorbed polymer layer examined in situ as a function of potential applied to a waveguide1. A layer of indium tin oxide (ITO) served as both a high refractive index waveguide for optical sensing, and a conductive electrode; an electrochemical flow-through fluid cell incorporated working, reference and counter electrodes. Poly(L-lysine)-grafted-poly(ethylene glycol) (PLL-g-PEG) served as a model, polycation adsorbate. Results indicate that adsorption and desorption of PLL-g-PEG from aqueous buffer are a function of applied potential, and that binding events subsequent to PLL-g-PEG functionalization are dependent on reorganization in the molecular adlayer.

  1. Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells.

    Science.gov (United States)

    Collins, Caitlin; Osborne, Lukas D; Guilluy, Christophe; Chen, Zhongming; O'Brien, E Tim; Reader, John S; Burridge, Keith; Superfine, Richard; Tzima, Ellie

    2014-06-11

    Endothelial cells (ECs) lining blood vessels express many mechanosensors, including platelet endothelial cell adhesion molecule-1 (PECAM-1), that convert mechanical force into biochemical signals. While it is accepted that mechanical stresses and the mechanical properties of ECs regulate vessel health, the relationship between force and biological response remains elusive. Here we show that ECs integrate mechanical forces and extracellular matrix (ECM) cues to modulate their own mechanical properties. We demonstrate that the ECM influences EC response to tension on PECAM-1. ECs adherent on collagen display divergent stiffening and focal adhesion growth compared with ECs on fibronectin. This is because of protein kinase A (PKA)-dependent serine phosphorylation and inactivation of RhoA. PKA signalling regulates focal adhesion dynamics and EC compliance in response to shear stress in vitro and in vivo. Our study identifies an ECM-specific, mechanosensitive signalling pathway that regulates EC compliance and may serve as an atheroprotective mechanism that maintains blood vessel integrity in vivo.

  2. socio-ec(h)o: Ambient Intelligence and Gameplay

    OpenAIRE

    Wakkary, Ron

    2005-01-01

    The socio-ec(h)o project aims to research a generalized ambient intelligent software platform and design models for responsive environments based on the concept of ambient intelligent "ecologies" and group gameplay. The benefits of the research include a software-architecture, ambient intelligence inference engine, and interaction design models for gameplay and responsive environments. The paper will discuss the results of our prototypes for games in responsive environments. These prototypes ...

  3. On E-C Translation of Proprietary Business Brand Terms

    Institute of Scientific and Technical Information of China (English)

    JIA Jun-min; ZHAO Wan-li

    2015-01-01

    An excellent translation of proprietary business brand terms is more important in international trade. Diverse cultural backgrounds and purposiveness of products are the most influential factors. The research tries to analyze the elements of cultural background and aims of products that affect E-C translation of proprietary business brand terms by descriptive study method and experience summary method, and then to provide methods to overcome these difficulties.

  4. Present status of developing petroleum-substituting energy (EC)

    Science.gov (United States)

    1993-03-01

    The EC has had approximately 50% of its total energy demand supplied by imports from the exterior of the Community. Hence, it is getting important to develop oil-substituting renewable energy as well as to curtail the emission of carbon dioxide. In consideration of these situations, the results of investigation on the energy policy of the European Community are described. The policy comprises three courses: European Energy Charter, formation of an open European Community energy market, and environmental conservation. Particularly, concerning the reduction of carbon dioxide emission, the EC Council has decided to introduce carbon dioxide taxation so as to suppress the carbon dioxide emission in the year 2000 to the 1990 level. The arrangement for its introduction, however, encountered with difficulties because of the opposition of various countries other than the European Community and the industrial world of the European Community. Legislation of the investment promotion law for energy saving and the construction of infrastructure footing and an information network are ineffective due to the sluggish fuel price and economic recession. A plurality of EC member countries are advancing a comprehensive activity within the framework of the joint programs of research, development, and demonstration set for the renewable energy policy ensuring energy supply and environmental harmonization.

  5. Seizure threshold to lidocaine is decreased following repeated ECS (electroconvulsive shock)

    DEFF Research Database (Denmark)

    Kragh, J; Seidelin, J; Bolwig, T G

    1993-01-01

    Seizure susceptibility to lidocaine was investigated in rats which had received repeated ECS (electroconvulsive shock). In the first experiment three groups of rats received an ECS daily for 18 days, an ECS weekly for 18 weeks, and 18 sham treatments, respectively. Twelve weeks after the last ECS......, had motor seizures in response to the LC. In the second experiment five groups of rats received an ECS daily for 0, 1, 6, 18, and 36 days, respectively. Eighteen weeks after the last ECS all rats received an LC and 0% (0/15), 13% (2/15), 20% (3/15), 53% (8/15), and 58% (7/12), respectively, developed...

  6. The ITER EC H and CD upper launcher: Structural system

    Energy Technology Data Exchange (ETDEWEB)

    Spaeh, Peter, E-mail: peter.spaeh@kit.edu [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Aiello, Gaetano; Gessner, Robby; Grossetti, Giovanni; Meier, Andreas; Scherer, Theo; Schreck, Sabine [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Serikov, Arkady [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Strauss, Dirk; Vaccaro, Alessandro [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Weinhorst, Bastian [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany)

    2013-10-15

    Highlights: ► ITER EC H and CD Launcher goes towards final design. ► European consortium founded for bringing the EC H and CD launcher towards final design. ► New design updates for dedicated components of the ITER EC H and CD launcher. -- Abstract: After approval of the preliminary design of the ITER EC H and CD Upper Launcher, ECHUL-CA, a consortium of several European research institutes, was founded to pool resources for approaching the final design. At the end of 2011 the consortium has signed a 2 years contract with F4E to go ahead with the work on the launcher. The contract deals with design work on both the port plug, forming the structural system, and the mm-wave-system, which injects the RF-power into the plasma. Within the period of this contract all components being part of the Tritium confinement, of which the closure plate, the support flange, the diamond windows and the waveguide feed-throughs are the most outstanding ones, will get the status of the final design. Important steps to be done for the structural system are the optimization of the mechanical behavior of the launcher, leading to minimum deflections of the port plug during plasma disruptions and optimum seismic resistance. To reduce the effect of halo currents it was decided to recess the first wall of 100 mm compared to the regular blanket tangent. This recess requires substantial changes of the cooling system and the thermo-hydraulic design of the launcher. Also the layout of the shielding arrangement and the integration of the mm-wave system need significant revision. Moreover manufacturing aspects and enhanced remote handling capability are taken into account. For the final design also quality aspects must be considered; thus the design is elaborated with respect to applicable codes and standards, material specifications, risk analyses and the RAMI (reliability, availability, maintainability and inspectability) analysis to guarantee maximum performance of the device. This paper

  7. Business-to-business electronic commerce systems and services. Smart EC solution; Kigyoka nrenkei system solution system. Smart EC solution

    Energy Technology Data Exchange (ETDEWEB)

    Setoguchi, T.; Manchu, Y.; Katsumata, M. [Toshiba Corp., Tokyo (Japan)

    2000-04-01

    Toshiba provides a range of information technology (IT) solutions called SmartEC Solution, which includes business-to-business electronic commerce systems and services based on international standards and industrial know-how, especially our electronic data interchange (EDI) know-how as a manufacturer. These IT solutions are supplied as services covering strategy planning, system integration, and application service provider based on five types of business-to-business electronic commerce. (author)

  8. 78 FR 60226 - Amendments To Implement Certain Provisions of the Moving Ahead for Progress in the 21st Century...

    Science.gov (United States)

    2013-10-01

    ..., Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, Apr. 23, 1997... equitable due to exceptional or uncontrollable circumstances, such as a natural disaster or a serious... Regulations amended by this final rule encompass diverse subject areas. Those amendments are explained...

  9. 78 FR 22411 - List of Approved Spent Fuel Storage Casks: HI-STORM 100, Amendment No. 8; Corrections

    Science.gov (United States)

    2013-04-16

    ... COMMISSION 10 CFR Part 72 RIN 3150-AJ05 List of Approved Spent Fuel Storage Casks: HI-STORM 100, Amendment No... direct final rule amending its spent fuel storage regulations by revising the Holtec International, Inc. (Holtec) HI-STORM 100 Cask System listing within the ``List of Approved Spent Fuel Storage Casks''...

  10. 77 FR 41716 - Amendment Relating to Reasonable Contract or Arrangement Under Section 408(b)(2)-Fee Disclosure...

    Science.gov (United States)

    2012-07-16

    ... Benefits Security Administration 29 CFR Part 2550 RIN 1210-AB54 Amendment Relating to Reasonable Contract....regulations.gov . Follow the instructions for submitting comments. Email: e-ORI@dol.gov . Mail or Hand... electronically to a specified email address (paragraph (c)(1)(ix)(F)). The direct final rule amends...

  11. Software Process Improvement to Assist Medical Device Software Development Organisations to Comply with the Amendments to the Medical Device Directive

    OpenAIRE

    Mc Hugh, Martin; McCaffery, Fergal; Casey, Valentine

    2012-01-01

    peer-reviewed A recent revision to the European Medical Device Directive (MDD) 2007/47/EC made fourteen amendments to the original directive (93/42/EEC). A number of these changes directly affect the development of software for use in healthcare. The most significant change in relation to medical device software development is that standalone software is now seen as an active medical device and should be developed following state of the art medical device software development p...

  12. Scientific Opinion on application (EFSA-GMO-NL-2010-78) for the placing on the market of herbicide-tolerant, increased oleic acid genetically modified soybean MON 87705 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto

    OpenAIRE

    EFSA Panel on Genetically Modified Organisms (GMO)

    2012-01-01

    This scientific opinion is a risk assessment of the genetically modified, herbicide-tolerant, increased oleic acid soybean MON 87705 for food and feed uses, import and processing. MON 87705 contains the soybean FAD2-1A/FATB1-A gene fragments down-regulating endogenous FAD2 and FATB enzymes and the CP4 epsps gene cassette conferring tolerance to glyphosate-containing herbicides. Bioinformatic analyses and genetic stability studies did not rais...

  13. EC6 for Darlington - a managed-enhancements replication project

    International Nuclear Information System (INIS)

    CANDU 6 design has a well-deserved reputation for lifetime performance and on-time, on-schedule construction. Candu Energy is finalizing development of an upgraded reactor product, the Enhanced CANDU 6 (EC6), which incorporates the CANDU 6's well-proven features, and adds enhancements that make the reactor even more safe and easier to operate. The EC6 is the only mid-sized reactor (700 MWe class) with a proven pedigree that meets modern reactor expectations and regulatory standards. It is sized for smaller grids and also has outstanding fuel-cycle capability. Some of the key features incorporated into the EC6 include increasing the plant's power output, shortening the overall project schedule, addressing obsolescence issues, optimizing maintenance outages and incorporating lessons learnt through feedback obtained from the operating plants. The EC6 utilizes modern computers and a distributed control system housed in an advanced control room which, along with automated testing and on-line diagnostics, make the plant easier and safer to operate, with minimal operator intervention. An array of health monitoring equipment are also installed to foretell impending equipment problems, which can be acted upon, avoiding complications that could result in forced shutdowns. Improvements to the fire protection system and enhanced security features will further protect the assets. Containment and seismic capability are upgraded to meet modern standards. The first deployment of the EC6 is anticipated in Canada; other markets are also being pursued. The EC6 reactor is designed for a target lifetime capacity factor of 92% including 94% year-to-year and a 1% Forced Loss Rate. Since the number and duration of maintenance outages impact plant capacity factors, periodic short duration maintenance outages of less than a month once every 36 months is a key target of the EC6 reactor. This objective is achieved by automating a number of tasks such as shutdown systems testing. The majority

  14. Latest Amendment to Criminal Law

    Institute of Scientific and Technical Information of China (English)

    ZHU ZONGJIE

    2011-01-01

    @@ On Feb.25, 2011,the 19th Session of the Standine Commlttee or the 11th National Peonle's Congress, the country's highest legislative body, approved the eighth amendment to the Criminal Law of the People's Republic of China.This brought about the broadest changes ever made to the law-to be precise, to 50 items that involve 49 legal matters.While reducing the number of crimes punishable by death, the amended Criminal Law provides for additional instances of leniency for senior citizens and minors who are convicted of a crime.

  15. Decree N0 67-880 of 20 September 1967 publishing the International Regulations for the Transport of dangerous Goods by Rail (RID), as amended on 1 April 1967

    International Nuclear Information System (INIS)

    This Decree provides that the RID shall be published in the Official Gazette of the French Republic. The Regulations are accordingly published as an Annex to the Official Gazette of the same date. (NEA)

  16. Archive of Geosample Data and Information from the U.S. Extended Continental Shelf (ECS) Project.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Geological samples collected as part of the U.S. Extended Continental Shelf (ECS) Project are curated by the U.S. Geological Survey, a partner in the ECS Project....

  17. Research on Intellectual Property Conflicts Identification in Knowledge Transferring among EC Enterprises

    Science.gov (United States)

    Su, Shibin

    As the lacks of existing research about intellectual property conflicts management of EC enterprise, the paper analysis the intellectual property conflicts in knowledge transferring among EC enterprises by intellectual property types, then, the paper makes research on intellectual property conflicts identification in knowledge transferring among EC enterprises, and gives relative assumption, meanwhile, the paper makes quantities identification of intellectual property conflicts in knowledge transferring among EC enterprises by evidential theory, finally, the paper gives the further research orientations.

  18. Regulation of the galanin system in the brainstem and hypothalamus by electroconvulsive stimulation in mice

    DEFF Research Database (Denmark)

    Christiansen, S H

    2011-01-01

    Induction of seizures by electroconvulsive stimulation (ECS) is amongst the most efficacious treatments for major depression. However, the working mechanism by which ECS exerts its antidepressant effects remains elusive. The galanin system is regulated by ECS in seizure-prone brain regions and ha...

  19. 32 CFR 10.8 - Amendment.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Amendment. 10.8 Section 10.8 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.8 Amendment. The General Counsel may issue, supplement, amend, or revoke any...

  20. 76 FR 80226 - Technical Amendments

    Science.gov (United States)

    2011-12-23

    ... From the Federal Register Online via the Government Publishing Office NATIONAL CREDIT UNION ADMINISTRATION 12 CFR Part 701 Technical Amendments AGENCY: National Credit Union Administration (NCUA). ACTION... to the Office of Consumer Protection. This authority previously sat with the regional directors....

  1. Automated Clustering of Similar Amendments

    CERN Document Server

    CERN. Geneva

    2016-01-01

    The Italian Senate is clogged by computer-generated amendments. This talk will describe a simple strategy to cluster them in an automated fashion, so that the appropriate Senate procedures can be used to get rid of them in one sweep.

  2. The First Amendment Right to Speak About the Human Genome

    Science.gov (United States)

    Evans, Barbara J.

    2014-01-01

    This article explores whether laws that restrict the communication of genetic test results may, under certain circumstances, violate the First Amendment to the U.S. Constitution. The focus is whether investigators have a right to return results from non-CLIA-certified laboratories in situations where a research participant requests the results and the investigator is willing to share them but is concerned that doing so may violate regulations under the Clinical Laboratory Improvement Amendments of 1988 (“CLIA”). This article takes no position on whether investigators can be compelled to return results when they do not wish to do so. It examines only whether investigators may, not whether they must, return results to a willing research participant. The article: (1) surveys state and federal laws that block communication of genetic test results to research participants; (2) examines the historical use of speech restrictions as a tool for protecting human research subjects; (3) traces how First Amendment doctrine has evolved since the 1970s when foundations of modern research bioethics were laid; (4) inquires whether recent bioethical and policy debate has accorded due weight to the First Amendment. The article applies two common methods of legal analysis, textual and constitutional analysis. It concludes that the CLIA regulations, when properly construed, do not treat the return of results as an event that triggers CLIA’s certification requirements. Moreover, there is a potential First Amendment problem in construing CLIA’s research exception in a way that bans the return of results from non-CLIA-certified laboratories. PMID:25473380

  3. Central Bank (Supervision and Enforcement) (Amendment) Bill 2016: Legislative Bill

    DEFF Research Database (Denmark)

    Butler, Graham; Rock, Noel

    2016-01-01

    Private Members' Bill (legislation) introduced in Dáil Éireann (House of Deputies), Houses of the Oireachtas (Irish Parliament). An Act to amend sections 49 and 51 of the Central Bank (Supervision and Enforcement) Act 2013 to ensure the powers exercised by the Central Bank of Ireland to make...... regulations, conferred by the Central Bank (Supervision and Enforcement) Act 2013 are fit for purpose; and to provide for related matters....

  4. Amended Silicated for Mercury Control

    Energy Technology Data Exchange (ETDEWEB)

    James Butz; Thomas Broderick; Craig Turchi

    2006-12-31

    Amended Silicates{trademark}, a powdered, noncarbon mercury-control sorbent, was tested at Duke Energy's Miami Fort Station, Unit 6 during the first quarter of 2006. Unit 6 is a 175-MW boiler with a cold-side electrostatic precipitator (ESP). The plant burns run-of-the-river eastern bituminous coal with typical ash contents ranging from 8-15% and sulfur contents from 1.6-2.6% on an as-received basis. The performance of the Amended Silicates sorbent was compared with that for powdered activated carbon (PAC). The trial began with a period of baseline monitoring during which no sorbent was injected. Sampling during this and subsequent periods indicated mercury capture by the native fly ash was less than 10%. After the baseline period, Amended Silicates sorbent was injected at several different ratios, followed by a 30-day trial at a fixed injection ratio of 5-6 lb/MMACF. After this period, PAC was injected to provide a comparison. Approximately 40% mercury control was achieved for both the Amended Silicates sorbent and PAC at injection ratios of 5-6 lbs/MMACF. Higher injection ratios did not achieve significantly increased removal. Similar removal efficiencies have been reported for PAC injection trials at other plants with cold-side ESPs, most notably for plants using medium to high sulfur coal. Sorbent injection did not detrimentally impact plant operations and testing confirmed that the use of Amended Silicates sorbent does not degrade fly ash quality (unlike PAC). The cost for mercury control using either PAC or Amended Silicates sorbent was estimated to be equivalent if fly ash sales are not a consideration. However, if the plant did sell fly ash, the effective cost for mercury control could more than double if those sales were no longer possible, due to lost by-product sales and additional cost for waste disposal. Accordingly, the use of Amended Silicates sorbent could reduce the overall cost of mercury control by 50% or more versus PAC for locations where

  5. Exfoliative cheilitis (EC) in AIDS: association with Candida infection.

    Science.gov (United States)

    Reichart, P A; Weigel, D; Schmidt-Westhausen, A; Pohle, H D

    1997-07-01

    Forty-seven of 165 patients with AIDS (28.5%) showed exfoliative cheilitis (EC), predominantly of the lower lip (n = 37). Histologically, hyphae were revealed in 23 of 47 cases (49%). In 14 of 23 specimens the histological and microbiological findings were in accordance. Smears of the vermilion border revealed Candida albicans in half of the cases (51%); however, combinations with C. krusei, C. tropicalis and C. glabrata were also seen. Twenty of 35 patients given fluconazole either prophylactically or therapeutically showed clinical signs of oral candidiasis. Frequent moistening of the lips may result in infection of the vermilion border with Candida species; consequent desiccation of the lips will lead to scale formation and exfoliation. Smears of the vermilion border of the lower lip of 20 controls with AIDS were positive in four cases. Twenty HIV-negative controls without EC showed negative microbiological results for Candida species. Exfoliative cheilitis may be associated with Candida infection in some cases and may be considered another variant of candidiasis in AIDS patients. PMID:9234190

  6. EC power sources: European technological developments towards ITER

    International Nuclear Information System (INIS)

    The activities in Europe towards the development of the EC power sources for ITER are centered on the development of a 170 GHz, 2 MW, CW coaxial cavity gyrotron of collector potential depressed (CPD) type. A gyrotron with a higher unit power than the ITER reference (1 MW) would yield a reduction of the installation costs, a more compact launcher design and, if required, an increase of the power delivered through one port. Tests proving the principle were successfully performed on a short-pulse experimental gyrotron delivering up to 2.2 MW in single mode. Following this success, a coordinated and fully consistent programme of development has been launched. The first industrial 2 MW prototype is now at an advanced stage of construction. The associated superconductive magnet producing 6.86 T on the cavity axis is also being procured. Dummy loads suitable for short and CW operation are also part of the development effort. Finally, a new EC test facility, with the features necessary for the testing of the gyrotron up to full power in CW, has been established and includes a fully solid-state power supply system

  7. Knowledge Preservation Management at EC-JRC Petten

    International Nuclear Information System (INIS)

    Often extensive material research programmes are necessary for new international energy related facilities such as fusion or GEN IV reactor systems to qualify new or modified materials. That is associated with high costs which one partner is hardly willing to invest. Therefore data exchange of experimental data between partners is probably the easiest solution to reduce the costs. Because of the traceability experimental test results are combined with complex metadata such as source information, chemical analysis, heat treatment, specimen dimensions or coating layers, test environment and service exposure, in-pile or out-of-pile irradiation. Due to the fact that partner organizations have heterogeneous databases data exchange by using EXCEL or SQL files is complicated and very time consuming. International agreed exchange platforms and formats have to be established to ease the mapping of database structures. EC-JRC Petten's task within the IAEA Coordinated Research Project (CRP) 'Comparative Analysis of Methods and Tools for Nuclear Knowledge Management' was the definition of such international agreed exchange formats including units and determination of mandatory metadata for experimental mechanical properties surveillance data of WWERs and Reactor Pressure Vessels (RPV's) to harmonize the Nuclear Safety Data Management and Dissemination practices. The exchange formats are established within the EC-JRC Petten materials database Mat-DB which is an integrated part of the ODIN portal.

  8. 欧盟荧光灯、高强度气体放电灯及配套镇流器与灯具生态设计要求法规解析%Interpretation & Analysis to EU Commission Regulation (EC) No 245/2009 on Ecodesign Requirements for Fluorescent Lamps without Integrated Ballast, for High Intensity Discharge Lamps,and for Ballasts and Luminaires Able to Operate Such Lamps

    Institute of Scientific and Technical Information of China (English)

    张俊斌

    2009-01-01

    欧盟为贯彻用能产品生态设计指令(EuP指令),已出台两个针对照明电器的法规.本文介绍了编号为(EC)No 245/2009法规的要求,解析了这些要求的用意.最后对两个法规的异同进行了小结和点评.

  9. Evaluation of the size segregation of elemental carbon (EC) emission in Europe: influence on the simulation of EC long-range transportation

    Science.gov (United States)

    Chen, Ying; Cheng, Ya-Fang; Nordmann, Stephan; Birmili, Wolfram; Denier van der Gon, Hugo A. C.; Ma, Nan; Wolke, Ralf; Wehner, Birgit; Sun, Jia; Spindler, Gerald; Mu, Qing; Pöschl, Ulrich; Su, Hang; Wiedensohler, Alfred

    2016-02-01

    Elemental Carbon (EC) has a significant impact on human health and climate change. In order to evaluate the size segregation of EC emission in the EUCAARI inventory and investigate its influence on the simulation of EC long-range transportation in Europe, we used the fully coupled online Weather Research and Forecasting/Chemistry model (WRF-Chem) at a resolution of 2 km focusing on a region in Germany, in conjunction with a high-resolution EC emission inventory. The ground meteorology conditions, vertical structure and wind pattern were well reproduced by the model. The simulations of particle number and/or mass size distributions were evaluated with observations at the central European background site Melpitz. The fine mode particle concentration was reasonably well simulated, but the coarse mode was substantially overestimated by the model mainly due to the plume with high EC concentration in coarse mode emitted by a nearby point source. The comparisons between simulated EC and Multi-angle Absorption Photometers (MAAP) measurements at Melpitz, Leipzig-TROPOS and Bösel indicated that the coarse mode EC (ECc) emitted from the nearby point sources might be overestimated by a factor of 2-10. The fraction of ECc was overestimated in the emission inventory by about 10-30 % for Russia and 5-10 % for Eastern Europe (e.g., Poland and Belarus). This incorrect size-dependent EC emission results in a shorter atmospheric life time of EC particles and inhibits the long-range transport of EC. A case study showed that this effect caused an underestimation of 20-40 % in the EC mass concentration in Germany under eastern wind pattern.

  10. 76 FR 40012 - Semiannual Agenda of Regulations

    Science.gov (United States)

    2011-07-07

    ... Recommendations on Sharks. 69 Amendment 15 to the 0648-BA71 Atlantic Sea Scallop Fishery Management Plan. 70... Whale Take 0648-BA30 Reduction Plan (Section 610 Review). 79 Amendment to Regulations 0648-BA34 Under... for 0648-AV15 Killer Whales in the Northwest Region Under the Endangered Species Act and Marine...

  11. PECAM-1 (CD31) regulates a hydrogen peroxide–activated nonselective cation channel in endothelial cells

    OpenAIRE

    Ji, Guangju; O'Brien, Christopher D.; Feldman, Morris; Manevich, Yefim; Lim, Poay; Sun, Jing; Albelda, Steven M.; Kotlikoff, Michael I.

    2002-01-01

    Hydrogen peroxide (H2O2) released by neutrophils is an important mediator of endothelial cell (EC) injury and vascular inflammation via its effect on EC-free Ca2+, [Ca2+]i. Although the underlying mechanisms are not well understood, platelet endothelial cell adhesion molecule (PECAM)-1/CD-31 is a critical modulator of neutrophil–EC transmigration. PECAM-1 is also known to regulate EC calcium signals and to undergo selective tyrosine phosphorylation. Here, we report that PECAM-1 molecules tran...

  12. Survival and Persistence of Nonpathogenic Escherichia coli and Attenuated Escherichia coli O157:H7 in Soils Amended with Animal Manure in a Greenhouse Environment.

    Science.gov (United States)

    Sharma, Manan; Millner, Patricia D; Hashem, Fawzy; Camp, Mary; Whyte, Celia; Graham, Lorna; Cotton, Corrie P

    2016-06-01

    Animal manure provides benefits to agriculture but may contain pathogens that contaminate ready-to-eat produce. U.S. Food and Drug Administration standards include 90- or 120-day intervals between application of manure and harvest of crop to minimize risks of pathogen contamination of fresh produce. Data on factors affecting survival of Escherichia coli in soils under greenhouse conditions are needed. Three separate studies were conducted to evaluate survival of nonpathogenic E. coli (gEc) and attenuated E. coli O157:H7 (attO157) inoculated at either low (4 log CFU/ml) or high (6 log CFU/ml) populations over 56 days. Studies involved two pot sizes (small, 398 cm(3); large, 89 liters), three soil types (sandy loam, SL; clay loam, CL; silt loam, SIL), and four amendments (poultry litter, PL; dairy manure liquids, DML; horse manure, HM; unamended). Amendments were applied to the surface of the soil in either small or large containers. Study 1, conducted in regularly irrigated small containers, showed that populations of gEc and attO157 (2.84 to 2.88 log CFU/g) in PL-amended soils were significantly (P < 0.05) greater than those in DML-amended (0.29 to 0.32 log CFU/g [dry weight] [gdw]) or unamended (0.25 to 0.28 log CFU/gdw) soils; soil type did not affect E. coli survival. Results from study 2, in large pots with CL and SIL, showed that PL-amended soils supported significantly higher attO157 and gEc populations compared with HM-amended or unamended soils. Study 3 compared results from small and large containers that received high inoculum simultaneously. Overall, in both small and large containers, PLamended soils supported higher gEc and attO157 populations compared with HM-amended and unamended soils. Populations of attO157 were significantly greater in small containers (1.83 log CFU/gdw) than in large containers (0.65 log CFU/gdw) at week 8, perhaps because small containers received more regular irrigation than large pots. Regular irrigation of small pots may have

  13. Conocarpus biochar as a soil amendment for reducing heavy metal availability and uptake by maize plants

    OpenAIRE

    Al-Wabel, Mohammad I.; Adel R. A. Usman; El-Naggar, Ahmed H.; Aly, Anwar A.; Ibrahim, Hesham M.; Elmaghraby, Salem; Al-Omran, Abdulrasoul

    2014-01-01

    The objective of this study was to assess the use of Concarpus biochar as a soil amendment for reducing heavy metal accessibility and uptake by maize plants (Zea mays L.). The impacts of biochar rates (0.0, 1.0, 3.0, and 5.0% w/w) and two soil moisture levels (75% and 100% of field capacity, FC) on immobilization and availability of Fe, Mn, Zn, Cd, Cu and Pb to maize plants as well as its application effects on soil pH, EC, bulk density, and moisture content were evaluated using heavy metal-c...

  14. Matrix stiffness regulates endothelial cell proliferation through septin 9.

    Directory of Open Access Journals (Sweden)

    Yi-Ting Yeh

    Full Text Available Endothelial proliferation, which is an important process in vascular homeostasis, can be regulated by the extracellular microenvironment. In this study we demonstrated that proliferation of endothelial cells (ECs was enhanced on hydrogels with high stiffness (HSG, 21.5 kPa in comparison to those with low stiffness (LSG, 1.72 kPa. ECs on HSG showed markedly prominent stress fibers and a higher RhoA activity than ECs on LSG. Blockade of RhoA attenuated stress fiber formation and proliferation of ECs on HSG, but had little effect on ECs on LSG; enhancement of RhoA had opposite effects. The phosphorylations of Src and Vav2, which are positive RhoA upstream effectors, were higher in ECs on HSG. The inhibition of Src/Vav2 attenuated the HSG-mediated RhoA activation and EC proliferation but exhibited nominal effects on ECs on LSG. Septin 9 (SEPT9, the negative upstream effector for RhoA, was significantly higher in ECs on LSG. The inhibition of SEPT9 increased RhoA activation, Src/Vav2 phosphorylations, and EC proliferation on LSG, but showed minor effects on ECs on HSG. We further demonstrated that the inactivation of integrin α(vβ(3 caused an increase of SEPT9 expression in ECs on HSG to attenuate Src/Vav2 phosphorylations and inhibit RhoA-dependent EC proliferation. These results demonstrate that the SEPT9/Src/Vav2/RhoA pathway constitutes an important molecular mechanism for the mechanical regulation of EC proliferation.

  15. Matrix Stiffness Regulates Endothelial Cell Proliferation through Septin 9

    Science.gov (United States)

    Yeh, Yi-Ting; Hur, Sung Sik; Chang, Joann; Wang, Kuei-Chun; Chiu, Jeng-Jiann; Li, Yi-Shuan; Chien, Shu

    2012-01-01

    Endothelial proliferation, which is an important process in vascular homeostasis, can be regulated by the extracellular microenvironment. In this study we demonstrated that proliferation of endothelial cells (ECs) was enhanced on hydrogels with high stiffness (HSG, 21.5 kPa) in comparison to those with low stiffness (LSG, 1.72 kPa). ECs on HSG showed markedly prominent stress fibers and a higher RhoA activity than ECs on LSG. Blockade of RhoA attenuated stress fiber formation and proliferation of ECs on HSG, but had little effect on ECs on LSG; enhancement of RhoA had opposite effects. The phosphorylations of Src and Vav2, which are positive RhoA upstream effectors, were higher in ECs on HSG. The inhibition of Src/Vav2 attenuated the HSG-mediated RhoA activation and EC proliferation but exhibited nominal effects on ECs on LSG. Septin 9 (SEPT9), the negative upstream effector for RhoA, was significantly higher in ECs on LSG. The inhibition of SEPT9 increased RhoA activation, Src/Vav2 phosphorylations, and EC proliferation on LSG, but showed minor effects on ECs on HSG. We further demonstrated that the inactivation of integrin αvβ3 caused an increase of SEPT9 expression in ECs on HSG to attenuate Src/Vav2 phosphorylations and inhibit RhoA-dependent EC proliferation. These results demonstrate that the SEPT9/Src/Vav2/RhoA pathway constitutes an important molecular mechanism for the mechanical regulation of EC proliferation. PMID:23118862

  16. Scientific Opinion on application (EFSA-GMO-NL-2010-78 for the placing on the market of herbicide-tolerant, increased oleic acid genetically modified soybean MON 87705 for food and feed uses, import and processing under Regulation (EC No 1829/2003 from Monsanto

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Genetically Modified Organisms (GMO

    2012-10-01

    Full Text Available

    This scientific opinion is a risk assessment of the genetically modified, herbicide-tolerant, increased oleic acid soybean MON 87705 for food and feed uses, import and processing. MON 87705 contains the soybean FAD2-1A/FATB1-A gene fragments down-regulating endogenous FAD2 and FATB enzymes and the CP4 epsps gene cassette conferring tolerance to glyphosate-containing herbicides. Bioinformatic analyses and genetic stability studies did not raise safety issues. The levels of the CP4 EPSPS protein in soybean MON 87705 have been sufficiently analysed. MON 87705 differs from the conventional counterpart in the fatty acid profile (proportion of (C18:1 oleic acid increased and proportions of (C18:2 linoleic acid and (C16:0 palmitic acid decreased in seeds and the presence of the CP4 EPSPS protein. Scientific risk assessment of soybean MON 87705 was carried out in the context of the intended use as specified by the applicant, namely its use for food and feed as any conventional soybean except for the oil derived from soybean MON 87705, which is to be used in margarine, salad dressing, mayonnaise and home-use liquid vegetable oil, excluding the use of soybean MON 87705 oil for commercial frying.

    The safety assessment identified no concerns regarding potential toxicity and allergenicity of the CP4 EPSPS protein. The altered fatty acid profile did not raise concerns regarding toxicity. The overall allergenicity of the whole plant was not changed by the genetic modification. The estimated changes in intake levels of these fatty acids do not raise nutritional concerns in the context of the intended use as specified by the applicant. A feeding study on broiler chickens confirmed that defatted meal of soybean MON 87705 is as nutritious as meals produced from its conventional counterpart and non-GM reference varieties. There are no indications of an increased likelihood of establishment and spread of feral soybean plants

  17. Insights into anticancer activity and mechanism of action of a ruthenium(II) complex in human esophageal squamous carcinoma EC109 cells.

    Science.gov (United States)

    Guo, Liubin; Lv, Gaochao; Qiu, Ling; Yang, Hui; Zhang, Li; Yu, Huixin; Zou, Meifen; Lin, Jianguo

    2016-09-01

    A ruthenium(II) complex [Ru(p-cymene)(NHC)Cl2] (NHC=1,3-bis(4-(tert-butyl)benzylimidazol-2-ylidene), referred to as L-4, has been designed and synthesized recently in order to look for new anticancer drugs with high efficacy and low side effects. The anticancer activity and mechanism of action of L-4 in human esophageal squamous carcinoma EC109 cells were systematically investigated. The results revealed that L-4 exerted strong inhibitory effect on the proliferation of EC109 cells, and it arrested EC109 cells at G2/M phase, accompanied with the up-regulation of p53 and p21 and the down-regulation of cyclin D1. The results also showed that the reactive oxygen species (ROS)-dependent apoptosis of EC109 can be induced by L-4 via inhibiting the activity of glutathione reductase (GR), decreasing the ratio of glutathione to oxidized glutathione (GSH/GSSG), and leading to the generation of reactive oxygen species. The mitochondria-mediated apoptosis of EC109 induced by L-4 was also observed from the increase of Bax/Bcl-2 ratio, overload of Ca(2+), disruption of mitochondrial membrane potential (MMP), redistribution of cytochrome c, and activation of caspase-3/-9. However, the effects of L-4 on the cell viability, GR activity, GSH/GSSG ratio, reactive oxygen species level, mitochondria dysfunction and apoptosis induction were remarkably attenuated by adding the reactive oxygen species scavenger, NAC. Therefore, it was concluded that L-4 can inhibit the proliferation of EC109 cells via blocking cell cycle progression and inducing reactive oxygen species-dependent and mitochondria-mediated apoptosis. These findings suggested that the ruthenium(II) complex might be a potential effective chemotherapeutic agent for human esophageal squamous carcinoma (ESCC) and worthy of further investigation. PMID:27262377

  18. Notch1通路活化抑制EC109细胞的增殖及机制探讨%Activated Notch1 signaling inhibits growth of EC109 cell line and its mechanism

    Institute of Scientific and Technical Information of China (English)

    张永利; 张可杰; 闵祥辉; 鹿全意; 刘文励

    2009-01-01

    Background and purpose: It has been reported that activation of Notch1 could strongly inhibit proliferation of HPV (human papilloma virus)-positive HeLa cells by down-regulation of the E6 and E7 genes. The aim of this paper was to investigate the role of the Notch signaling pathway in growth arrest of EC109 cells in vitro and the molecular mechanism. Methods: EC109 cell lines, a well differentiated human ESCC (esophageal squamous cell carcinoma) cell line with HPV18-positive, was used in the study. Exogenous intracellular domain of Notch1(ICN) was transfected into cultured EC109 cells by lipofectamine transfection, the proliferation of the transfected cells was measured by an MTT assay. Cell cycle distribution was analyzed by flow cytometry. Human papilloma virus type 18 (HPV18) E6/E7 mRNA expression was detected by RT-PCR, and p53 protein expression was detected by Western blot.Results: Activation of Notchl signaling resulted in inhibition of EC109 cell proliferation with the induction of G_2/ M arrest. There was a significant difference in terms of the percentage of G_2/M phase cells among the ICN-transfected group (42.57±1.57)% and the non-transfected group (1.88±0.66)% or the empty plasmid transfected group (1.99±1.02)% (P<0.01). Down modulation of HPV18 E6/E7 gene expression and upregulation of p53 expression was (2.15±0.23) in ICN-transfected group higher than non- transfected group (0.45±0.07) and empty plasmid transfected group (0.46±0.02) (P<0.01). Conclusion: Repression of HPV18 E6/E7 expression by Notch1 signaling results in growth suppression of HPV18-positive EC109 cells with concomitant activation of p53-mediated pathways.%背景与目的:Notch1的活化可以通过下调人类乳头状瘤病毒(human papillomavirus,HPV)早期蛋白E6和E7基因的表达抑制HPV阳性HeLa细胞系的增殖.人食管鳞状细胞癌细胞系EC109细胞为HPV18阳性细胞.本研究将Notch1胞内段(intracellular domain of Notch,ICN)转入EC109细胞,导致EC109

  19. Scientific Opinion on the substantiation of health claims related to various microorganisms and reduction of gastro-intestinal discomfort (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970, decreasing potentially pathogenic gastro-intestinal microorganisms (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970, improved lactose digestion (ID 1030, 2956, 2958, 2961, 2963, 2966, 2970, “intestinal flora/digestive health” (ID 4231, defence against vaginal pathogens (ID 2950, 2957, 2967 and increasing IL-10 production and/or enhancing the activity of natural killer cells (ID 2960, 2962, 2971 (further assessment pursuant to Article 13(1 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-08-01

    Full Text Available

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to provide a scientific opinion on health claims pursuant to Article 13 of Regulation (EC No 1924/2006 in the framework of further assessment related to various microorganisms and reduction of gastro-intestinal discomfort, decreasing potentially pathogenic gastro-intestinal microorganisms, improved lactose digestion, “intestinal flora/digestive health”, defence against vaginal pathogens and increasing IL-10 production and/or enhancing the activity of natural killer cells. The food constituents Lactobacillus crispatus BCCM/LMG P-17631, Lactobacillus gasseri BCCM/LMG P-17632, Lactobacillus gasseri BCCM/LMG P-18137, Lactobacillus paracasei CNCM I-1687, Lactobacillus paracasei CNCM I-1688, Lactobacillus plantarum BCCM/LMG P-17630, Lactobacillus salivarius CNCM I-1794 and a combination of Bifidobacterium animalis ssp. lactis Bf-6 and Lactobacillus johnsonii La-1 (ACD-1(CLbA22 are sufficiently characterised. The evidence provided did not establish that the proposed claimed effect, increasing IL-10 production and/or enhancing the activity of natural killer cells, is a beneficial physiological effect. The claimed effect “intestinal flora/digestive health” is general and non-specific, and does not refer to any specific health claim as required by Regulation (EC No 1924/2006. The references provided in relation to the claims evaluated in this opinion included studies which assessed the effects of food constituents other than the food constituents which are the subject of the claims and/or investigated health outcomes unrelated to the claimed effects. No human studies which investigated the effects of the food constituents on appropriate measures of the claimed effects were provided. On the basis of the data presented, the Panel

  20. Stability and preclinical tests of 99mTc-EC radiopharmaceuticals for renal function imaging

    International Nuclear Information System (INIS)

    Radiopharmaceuticals have shown a real and specific usefulness in medical services, especially for diagnosis of several diseases such as renal function imaging. Preparation of 99mTc-EC and its analysis have been carried out. The preparation consisted of several steps, characterization of EC with FT-IR, formulation of EC kit, labeling of EC with 99mTc followed by radiochemical purity testing using paper chromatography. Stability test of EC kit is to know The expired date has been carried out. Biodistribution test on normal mice was carried out while imaging in wistar rat using gamma camera The FT-IR and melting point analysis results showed that EC can be used for formulation of EC kit. The radiochemical purity of 99mTc-EC is analysed with paper chromatography with the result is higher than 95 %. The stability test showed that EC kit was stable until 5 months and the labeled EC at room temperature was stable after 4 hour incubation post labeling, biodistribution test on mice showed higher uptake in bladder, while imaging with gamma camera showed quite clearly in the kidney area. (author)

  1. EcPV2 DNA in equine genital squamous cell carcinomas and normal genital mucosa.

    Science.gov (United States)

    Bogaert, Lies; Willemsen, Anouk; Vanderstraeten, Eva; Bracho, Maria A; De Baere, Cindy; Bravo, Ignacio G; Martens, Ann

    2012-07-01

    Squamous cell carcinoma (SCC) represents the most common genital malignant tumor in horses. Similar to humans, papillomaviruses (PVs) have been proposed as etiological agents and recently Equine papillomavirus type 2 (EcPV2) has been identified in a subset of genital SCCs. The goals of this study were (1) to determine the prevalence of EcPV2 DNA in tissue samples from equine genital SCCs, penile intraepithelial neoplasia (PIN) and penile papillomas, using EcPV2-specific PCR, (2) to examine the prevalence of latent EcPV2 infection in healthy genital mucosa and (3) to determine genetic variability within EcPV2 and to disentangle phylogenetic relationships of EcPV2 among PVs. EcPV2 DNA was detected in all but one penile SCC (15/16), in all PIN lesions (8/8) and penile papillomas (4/4). Additionally, EcPV2 DNA was demonstrated in one of two metastasized lymph nodes, one contact metastasis in the mouth, two vaginal and one anal lesion. In healthy horses, EcPV2 DNA was detected in 10% (4/39) of penile swabs but in none of vulvovaginal swabs (0/20). This study confirms the presence of EcPV2 DNA in equine genital SCCs and shows its involvement in anal lesions, a lymph node and contact metastases. Latent EcPV2 presence was also shown in normal male genital mucosa. We found that different EcPV2 variants cocirculate among horses and that EcPV2 is related to the Delta+Zeta PVs and is only a very distant relative of high-risk human PVs causing genital cancer. Thus, similar viral tropism and similar malignant outcome of the infection do not imply close evolutionary relationship.

  2. Annual report 2011 the Norwegian energy regulator

    Energy Technology Data Exchange (ETDEWEB)

    Soeiland, Arne; Lund, Per Tore

    2012-07-01

    The report provides an overview of the current regulation of the electricity and district heating markets in Norway, and explains relevant market developments. An overview of legislative amendments, research work and international participation is also presented in the report (Author)

  3. Plant Life Management of the EC6 Concrete Containment Structure

    International Nuclear Information System (INIS)

    Aging of reinforced concrete structures due to service conditions, aggressive environments, or accidents may cause their strength, serviceability and durability to decrease over time. Due to the complex nature of safety-related structures in nuclear power plants in comparison to other structures, they possess a number of characteristics that make them comparison to other structures, they possess a number of characteristics that make them unique. These characteristics are: thick concrete cross-sections, heavy reinforcement, often one-side access only, subjected to such ageing stresses as irradiation and elevated temperature, in addition to other typical ageing mechanisms (i. e., exposure to freeze/thaw cycles, aggressive chemicals, etc.) that typically affects other types of non-nuclear structures. For a new plant, the Plant Life Management Program (PLiM) should start in the design process and then continues through construction, plant operation and decommissioning. Hence PLiM must provide not only Ageing Management program (AMP) but also provide requirements on material characteristic and the design criteria as well. The purpose of this paper is to present the Plant Life Management (PLiM) strategy for the concrete containment structure of EC6 (Enhanced CANDU 6) Nuclear Power Plant designed by CANDU Energy Inc. The EC6 is designed for 100-year plant life including a 60-year operating life and an additional 40-year decommissioning period of time. The approach adopted for the PLiM strategy of the concrete containment structure is a preventive one, key areas being: 1) design methodology, 2) material performance and 3) life cycle management and ageing management program. In addition to strength and serviceability, durability is a major consideration during the design phase, service life and up to the completion of decommissioning. Factors affecting durability design include: a) concrete performance, b) structural application, and c) consideration of environmental

  4. 77 FR 61281 - Regulation of Fuels and Fuel Additives: Modifications to Renewable Fuel Standard and Diesel...

    Science.gov (United States)

    2012-10-09

    ... EISA to reduce or replace the use of fossil fuels.\\5\\ \\5\\ 75 FR 14670, 14687 (March 26, 2010). The... amended definition. Producers or importers of fuel oil that meets the amended definition of heating oil... the RFS regulations. This amendment will not modify or limit fuel included in the current...

  5. An upper bound on the size of m-ary t-sEC/AUED codes

    Institute of Scientific and Technical Information of China (English)

    ZHANG Peng-cheng; FU Fang-wei; CHANG Zu-ling

    2006-01-01

    Finding good upper bound for the size of m-ary t-symmetric error correcting codes (t-sEC/AUED codes) codes is the main problem in the coding theory of m-ary t-sEC/AUED codes. Based on the method of Lagrange multipliers, We shall derive an upper bound on the size of m-ary t-sEC/AUED in this paper. Some examples achieved this upper bound are also given in this paper.

  6. Adaptation of the Emotional Contagion Scale (ECS) and gender differences within the Greek cultural context

    OpenAIRE

    Damigos Dimitris; Skapinakis Petros; Kevrekidis Pantelis; Mavreas Venetsanos

    2008-01-01

    Abstract Background The Emotional Contagion Scale (ECS) is a self-report scale used to measure individual differences in susceptibility to converge towards the emotions expressed by others. The main aim of the present paper was to examine the psychometric properties of the Greek translation of the scale. Methods The Greek ECS was completed by 691 undergraduate students (312 males and 379 females). To investigate the factor structure of the ECS, principal components analysis (PCA) was used. Re...

  7. of intestinal microflora” pursuant to Article 14 of Regulation (EC) No 1924/2006

    DEFF Research Database (Denmark)

    Tetens, Inge

    of a health claim related to a combination of Lactobacillus delbrueckii subsp. bulgaricus AY/CSL (LMG P-17224) and Streptococcus thermophilus 9Y/CSL (LMG P-17225) and “beneficial modulation of intestinal microflora”. The scope of the application was proposed to fall under a health claim referring to children...... microflora”. The target population, as proposed by the applicant, is children from 3 months to 14 years old. No evidence has been provided by the applicant to establish that the claimed effect, “beneficial modulation of the intestinal microflora”, is a beneficial physiological effect. The Panel concludes...... of the intestinal microflora”. © European Food Safety Authority, 2011...

  8. Application of EMAT/EC dual probe to monitoring of wall thinning in high temperature environment

    International Nuclear Information System (INIS)

    The authors have proposed EMAT (Electromagnetic Acoustic Transducer) and EC (Eddy Current) dual probe which provides sizing with high reliability based on the complementarity between eddy current testing and ultrasonic testing. In the previous work, the feasibility of EMAT/EC dual probe was verified through experiment using austenitic stainless steel plates with thinning defects. This paper discusses the feasibility of monitoring in high temperature environment using the EMAT/EC dual probe. For the purpose, EMAT/EC dual probe for high temperature is designed and fabricated, and the basic performance is investigated in high temperature environment. (author)

  9. The ITER EC H and CD Upper Launcher: Maintenance concepts

    International Nuclear Information System (INIS)

    Highlights: ► We explain how an overall maintenance strategy defines individual maintenance tasks. ► Concepts are presented for replacement strategies of the in-vessel optical components. ► Vertical placement of the Upper Launcher in the Hot Cell may simplify maintenance. -- Abstract: Maintenance of the ITER EC H and CD Upper Launcher (UL) shall be performed through the use of Remote Handling (RH) in the ITER Hot Cell Facility (HCF). The UL design will have to be fully compliant with ITER RH maintenance requirements and the set of RH tooling and services available in the HCF. This paper describes the development of an overall maintenance strategy for the UL, starting from a listing of all conceivable maintenance operations, including hands-on tasks. Components for which design concepts are discussed in this paper are the Blanket Shield Module (BSM), the steering mirror (M4), the mid optics (M1, M2) and the waveguide (WG) feed-through plate. Aspects related to RH documentation, overall maintenance strategy and design concepts for optimizing the maintainability of the UL are presented

  10. EC infuses Serbian nuclear relic cleanup with critical donation

    International Nuclear Information System (INIS)

    . In addition to the radiological legacy at Vinca, security had long been a source of concern. The reactor has been offline since 1984, and much of the dangerous material and facilities were inadequately protected. Thanks to funding and other support activities provided by the Serbian government and the USA for security upgrades and police support, overall site security has been substantially improved over the past two years. Yet more needs to be done, and time is running out. Along with the EC's recent donation, an additional $25 million must be raised by 2010 to meet a crucial deadline. The fuel needs to be shipped back to Russia by the end of 2010 or the job falls off the shipping schedule, and potential funding for VIND would also dry up should the 2010 target date be missed. VIND is the largest one-house programme within the IAEA, and the EC contribution is the largest single contribution ever received for a Technical Cooperation (TC) national project. 'The EC support was absolutely crucial to the life of the programme, but we have quite a way to go to find the remaining $25 million for the project,' said Kelly. 'The EC contribution serves as a great example and encourages other potential donors to invest in an important and successful project.' Background: Located on the outskirts of Belgrade, the 'Institute for Nuclear Sciences (Vinca)' was set up as a research centre in the former Yugoslavia in the 1950s. A civilian nuclear research reactor loaded with high-enriched uranium was housed at the site. The area was also a central radioactive waste collection and consolidation centre for the former Yugoslavia. The grounds at Vinca accumulated all the former country's dangerous radioactive waste and other radioactive sources for nearly 45 years, and though the reactor went offline in 1984, the radioactive waste and sources received from around the country continued to pile up. International concern about Vinca mushroomed in the 1990s after the break-up of the former

  11. 78 FR 29245 - U.S. General Services Administration Federal Property Management Regulations; Administrative Wage...

    Science.gov (United States)

    2013-05-20

    ... Administration Federal Property Management Regulations; Administrative Wage Garnishment AGENCY: Office of the... amending the U.S. General Services Administration Property Management Regulation (GSPMR) to remove... telephone number. The Administrative Wage Garnishment Code of Federal Regulations (CFR) Parts affected...

  12. 76 FR 74755 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2011-12-01

    ... Regulation, Labor Law Violations AGENCY: Office of Procurement and Property Management, Department of... not preempt State or local laws, regulations, or policies unless they present an irreconcilable... Department of Agriculture (USDA) proposes to amend the Agriculture Acquisition Regulation (the ``AGAR'')...

  13. 77 FR 2011 - Reorganization of Regulations on the Adjudication of Department of Homeland Security Practitioner...

    Science.gov (United States)

    2012-01-13

    ...The Department of Justice is amending its regulations governing the discipline of immigration practitioners as follows. First, the Department is removing unnecessary regulations and adding appropriate references to applicable regulations of the Department of Homeland Security (DHS). Second, the Department is making technical amendments to the Executive Office for Immigration Review's (EOIR)......

  14. 75 FR 26121 - Regulation of Fuels and Fuel Additives: Alternative Affirmative Defense Requirements for Ultra...

    Science.gov (United States)

    2010-05-11

    ... regulatory quality assurance requirement. This rule also amends the gasoline benzene regulations to allow... a separate document that will serve as the proposed rule to amend the diesel sulfur regulations and the gasoline benzene regulations if adverse comments are received on this direct final rule. We do...

  15. Toxicity of emerging energetic soil contaminant CL-20 to potworm Enchytraeus crypticus in freshly amended or weathered and aged treatments.

    Science.gov (United States)

    Kuperman, Roman G; Checkai, Ronald T; Simini, Michael; Phillips, Carlton T; Anthony, J Steven; Kolakowski, Jan E; Davis, Emily A

    2006-03-01

    We investigated the toxicity of an emerging polynitramine energetic material hexanitrohexaazaisowurtzitane (CL-20) to the soil invertebrate species Enchytraeus crypticus by adapting then using the Enchytraeid Reproduction Test (ISO/16387:2003). Studies were designed to develop ecotoxicological benchmark values for ecological risk assessment of the potential impacts of accidental release of this compound into the environment. Tests were conducted in Sassafras Sandy Loam soil, which supports relatively high bioavailability of CL-20. Weathering and aging procedures for CL-20 amended into test soil were incorporated into the study design to produce toxicity data that better reflect soil exposure conditions in the field compared with the toxicity in freshly amended soils. Concentration-response relationships for measurement endpoints were determined using nonlinear regressions. Definitive tests showed that toxicities for E. crypticus adult survival and juvenile production were significantly increased in weathered and aged soil treatments compared with toxicity in freshly amended soil, based on 95% confidence intervals. The median effect concentration (EC50) and EC20 values for juvenile production were 0.3 and 0.1 mg kg-1, respectively, for CL-20 freshly amended into soil, and 0.1 and 0.035 mg kg-1, respectively, for weathered and aged CL-20 soil treatments. These findings of increased toxicity to E. crypticus in weathered and aged CL-20 soil treatments compared with exposures in freshly amended soils show that future investigations should include a weathering and aging component to generate toxicity data that provide more complete information on ecotoxicological effects of emerging energetic contaminants in soil. PMID:16213571

  16. Tbx1 regulates brain vascularization.

    Science.gov (United States)

    Cioffi, Sara; Martucciello, Stefania; Fulcoli, Filomena Gabriella; Bilio, Marchesa; Ferrentino, Rosa; Nusco, Edoardo; Illingworth, Elizabeth

    2014-01-01

    The transcription factor TBX1 is the major gene involved in 22q11.2 deletion syndrome (22q11.2DS). Using mouse models of these diseases, we have previously shown that TBX1 activates VEGFR3 in endothelial cells (EC), and that this interaction is critical for the development of the lymphatic vasculature. In this study, we show that TBX1 regulates brain angiogenesis. Using loss-of-function genetics and molecular approaches, we show that TBX1 regulates the VEGFR3 and DLL4 genes in brain ECs. In mice, loss of TBX1 causes global brain vascular defects, comprising brain vessel hyperplasia, enhanced angiogenic sprouting and vessel network disorganization. This phenotype is recapitulated in EC-specific Tbx1 conditional mutants and in an EC-only 3-dimensional cell culture system (matrigel), indicating that the brain vascular phenotype is cell autonomous. Furthermore, EC-specific conditional Tbx1 mutants have poorly perfused brain vessels and brain hypoxia, indicating that the expanded vascular network is functionally impaired. In EC-matrigel cultures, a Notch1 agonist is able to partially rescue microtubule hyperbranching induced by TBX1 knockdown. Thus, we have identified a novel transcriptional regulator of angiogenesis that exerts its effect in brain by negatively regulating angiogenesis through the DLL4/Notch1-VEGFR3 regulatory axis. Given the similarity of the phenotypic consequences of TBX1 mutation in humans and mice, this unexpected role of TBX1 in murine brain vascularization should stimulate clinicians to search for brain microvascular anomalies in 22q11.2DS patients and to evaluate whether some of the anatomical and functional brain anomalies in patients may have a microvascular origin. PMID:23945394

  17. GCP inspections in Germany and Europe following the implementation of the Directive 2001/20/EC

    Directory of Open Access Journals (Sweden)

    Hundt, Ferdinand

    2009-03-01

    Full Text Available Background: The implementation of the Clinical Trials Directive 2001/20/EC and the Good Clinical Practice Directive 2005/28/EC fundamentally restructured and harmonized the conduct of clinical trials in Europe. GCP inspections – which affect study sites, laboratories, sponsors and contract research organizations (CRO alike – make up an important part of these regulations. A common understanding of how these regulations apply in daily life is however not always ensured. Methods: A working group of the Clinical Research/Quality Assurance subcommittee of the German Association of Research-Based Pharmaceutical Companies (VFA was established to outline the regulatory requirements, the experience gathered with inspections by means of a survey and to set up guidance on how to manage an inspection. Results and conclusions: The survey, conducted with the help of 15 pharmaceutical companies within the VFA, included a total of 224 inspections (74 inspections in Germany, 150 from other European countries. Most frequent findings in and outside Germany were related to “documentation” (40.5% vs. 21.3%, “investigational new drugs” (16.2% vs. 14.7%, “drug safety” (13.5% vs. 8% and “application for a clinical trial authorization” (5.4% vs. 12%. From a German perspective, key findings of this working group were the necessity for a clear differentiation of responsibilities between national and federal as well as international authorities, a harmonization of inspection procedures and topics, and a clarification of whether pre-study/on-study and pre-approval/post-approval GCP inspections of the federal higher authority are included in the “Zentralstelle der Länder für Gesundheitsschutz bei Arzneimitteln und Medizinprodukten” (ZLG requirements. The survey illustrated, that inspections usually are conducted at the investigational site, and that most of the findings are well known and thus could be prevented by communicating and discussing

  18. 77 FR 58301 - Technical Amendment; Airworthiness Standards: Aircraft Engines; Correction

    Science.gov (United States)

    2012-09-20

    ... Technical Amendment entitled, ``Airworthiness Standards: Aircraft Engine'' (77 FR 39623). In that technical... Administration 14 CFR Part 33 RIN 2120-AF57 Technical Amendment; Airworthiness Standards: Aircraft Engines... technical amendment, the FAA clarified aircraft engine vibration test requirements in the...

  19. The potential of residues of furfural and biogas as calcareous soil amendments for corn seed production.

    Science.gov (United States)

    Zhao, Yunchen; Yan, Zhibin; Qin, Jiahai; Ma, Zhijun; Zhang, Youfu; Zhang, Li

    2016-04-01

    Intensive corn seed production in Northwest of China produced large amounts of furfural residues, which represents higher treatment cost and environmental issue. The broad calcareous soils in the Northwest of China exhibit low organic matter content and high pH, which led to lower fertility and lower productivity. Recycling furfural residues as soil organic and nutrient amendment might be a promising agricultural practice to calcareous soils. A 3-year field study was conducted to evaluate the effects of furfural as a soil amendment on corn seed production on calcareous soil with compared to biogas residues. Soil physical-chemical properties, soil enzyme activities, and soil heavy metal concentrations were assessed in the last year after the last application. Corn yield was determined in each year. Furfural residue amendments significantly decreased soil pH and soil bulk density. Furfural residues combined with commercial fertilizers resulted in the greater cumulative on soil organic matter, total phosphorus, available phosphorus, available potassium, and cation exchange capacity than that of biogas residue. Simultaneously, urease, invertase, catalase, and alkaline phosphatase increased even at the higher furfural application rates. Maize seed yield increased even with lower furfural residue application rates. Furfural residues resulted in lower Zn concentration and higher Cd concentration than that of biogas residues. Amendment of furfural residues led to higher soil electrical conductivity (EC) than that of biogas residues. The addition of furfural residues to maize seed production may be considered to be a good strategy for recycling the waste, converting it into a potential resource as organic amendment in arid and semi-arid calcareous soils, and may help to reduce the use of mineral chemical fertilizers in these soils. However, the impact of its application on soil health needs to be established in long-term basis. PMID:26606935

  20. The potential of residues of furfural and biogas as calcareous soil amendments for corn seed production.

    Science.gov (United States)

    Zhao, Yunchen; Yan, Zhibin; Qin, Jiahai; Ma, Zhijun; Zhang, Youfu; Zhang, Li

    2016-04-01

    Intensive corn seed production in Northwest of China produced large amounts of furfural residues, which represents higher treatment cost and environmental issue. The broad calcareous soils in the Northwest of China exhibit low organic matter content and high pH, which led to lower fertility and lower productivity. Recycling furfural residues as soil organic and nutrient amendment might be a promising agricultural practice to calcareous soils. A 3-year field study was conducted to evaluate the effects of furfural as a soil amendment on corn seed production on calcareous soil with compared to biogas residues. Soil physical-chemical properties, soil enzyme activities, and soil heavy metal concentrations were assessed in the last year after the last application. Corn yield was determined in each year. Furfural residue amendments significantly decreased soil pH and soil bulk density. Furfural residues combined with commercial fertilizers resulted in the greater cumulative on soil organic matter, total phosphorus, available phosphorus, available potassium, and cation exchange capacity than that of biogas residue. Simultaneously, urease, invertase, catalase, and alkaline phosphatase increased even at the higher furfural application rates. Maize seed yield increased even with lower furfural residue application rates. Furfural residues resulted in lower Zn concentration and higher Cd concentration than that of biogas residues. Amendment of furfural residues led to higher soil electrical conductivity (EC) than that of biogas residues. The addition of furfural residues to maize seed production may be considered to be a good strategy for recycling the waste, converting it into a potential resource as organic amendment in arid and semi-arid calcareous soils, and may help to reduce the use of mineral chemical fertilizers in these soils. However, the impact of its application on soil health needs to be established in long-term basis.

  1. Completion Report for Well ER-EC-2A

    Energy Technology Data Exchange (ETDEWEB)

    M. J. Townsend

    2002-03-01

    Well ER-EC-2A was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in January and February of 2000 as part of a hydrogeologic investigation program in the Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 412.9 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,516.1 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 228.0 meters, approximately two months after installation of the completion string. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters, and 81 sidewall samples taken at various depths below 212 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 30 samples. The well was collared in rhyolite lava and penetrated Tertiary-age lava and tuff of the Volcanics of Fortymile Canyon and the Timber Mountain Group. The preliminary geologic interpretation of borehole data indicates that this well was drilled within the margins of the buried Rainier Mesa and Ammonia Tanks calderas, and that caldera collapse in this area was deeper than expected, resulting in a section of Volcanics of Fortymile Canyon (caldera-filling deposit) that is much thicker than expected.

  2. Completion Report for Well ER-EC-7

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2004-10-01

    Well ER-EC-7 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 265.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 422.5 meters. The planned depth of 762 meters was not reached due to borehole stability problems. One completion string with two isolated slotted intervals was installed in the well. A preliminary composite, static, water level was measured at the depth of 227.8 meters, 20 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on composite drill cuttings, supplemented by geophysical log data, and incorporating data from detailed chemical and mineralogical studies of rock samples. Beneath a thin alluvial deposit, the well penetrated 410 meters of lava and bedded tuff of the Volcanics of Fortymile Canyon Group, deposited in the Timber Mountain caldera moat after caldera collapse. The geologic interpretation of data from this well provides information on the thickness, lithologic composition, and hydrogeologic character of moat-filling rocks in the southern portion of the Timber Mountain caldera complex in the southwestern Nevada volcanic field.

  3. Completion Report for Well ER-EC-5

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2004-10-01

    Well ER-EC-5 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 342.6 meters below ground surface. The borehole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 762.0 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 309.9 meters, 40 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters, and 18 sidewall samples taken at various depths below 349.6 meters, supplemented by geophysical log data and results from detailed chemical and mineralogical analyses of rock samples. The well penetrated Tertiary-age tuffs of the Thirsty Canyon Group, caldera moat-filling sedimentary deposits, lava of the Beatty Wash Formation, and landslide breccia and tuffs of the Timber Mountain Group. The well reached total depth in welded ashflow tuff of the Ammonia Tanks Tuff after penetrating 440.1 meters of this unit, which is also the main water-producing unit in the well. The geologic interpretation of data from this well constrains the western margin of the Ammonia Tanks caldera to the west of the well location.

  4. Completion Report for Well ER-EC-8

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2004-10-01

    Well ER-EC-8 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 129.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 609.6 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 98.4 meters, 24 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on evaluation of composite drill cuttings collected every 3 meters, and 20 sidewall samples taken at various depths below 157.9 meters, supplemented by geophysical log data and results of detailed chemical and mineralogical studies of rock samples. Drilling began in Tertiary-age tuff of the Thirsty Canyon Group, and penetrated tuffs of the Beatty Wash Formation, tuff of Buttonhook Wash, and the upper portion of the Ammonia Tanks Tuff. The geologic interpretation of data from this well helps define the location of the western margin of the Timber Mountain caldera complex in the southwestern Nevada volcanic field. Geologic and hydrologic data from the well will aid in development of models to predict groundwater flow and contaminant migration within and near the Nevada Test Site.

  5. Completion report for Well ER-EC-6

    Energy Technology Data Exchange (ETDEWEB)

    M. J. Townsend

    2000-05-01

    Well ER-EC-6 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the DOE's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 66-centimeter surface hole was drilled and cased off to the depth of 485.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 434.6 meters prior to installation of the completion string. One completion string with four isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 33 sidewall samples taken at various depths below 504.4 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, and the Volcanics of Quartz Mountain. Intense hydrothermal alteration was observed below the depth of 640 m. The preliminary geologic interpretation indicates that this site may be located on a buried structural ridge that separates the Silent Canyon and Timber Mountain caldera complexes.

  6. Student Assistance Education Amendments of 1980.

    Science.gov (United States)

    Office of Student Financial Assistance (ED), Washington, DC.

    Information and guidelines for implementing the various amendments to the federal student financial aid programs are provided. The provisions are effective October 1, 1980 through 1985, except for the Guaranteed Student Loan Program amendments, effective January 1, 1980. General provisions are outlined, concerning the new administrative cost…

  7. 42 CFR 457.60 - Amendments.

    Science.gov (United States)

    2010-10-01

    ... Child Health Insurance Programs and Outreach Strategies § 457.60 Amendments. A State may seek to amend....490. (6) Cost-sharing as described in § 457.505. (7) Screen and enroll procedures, and other Medicaid... changes in the type of non-health care related revenues used to generate general revenue....

  8. 14 CFR 17.45 - Conforming amendments.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Conforming amendments. 17.45 Section 17.45 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES PROCEDURES FOR PROTESTS AND CONTRACTS DISPUTES Finality and Review § 17.45 Conforming amendments. The...

  9. 47 CFR 3.27 - Amended application.

    Science.gov (United States)

    2010-10-01

    ... AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Application Procedures § 3.27 Amended application. Changes in circumstances that cause information previously supplied to the FCC to be incorrect or... 47 Telecommunication 1 2010-10-01 2010-10-01 false Amended application. 3.27 Section...

  10. Status of Europe’s contribution to the ITER EC system

    Directory of Open Access Journals (Sweden)

    Albajar F.

    2015-01-01

    Full Text Available The electron cyclotron (EC system of ITER for the initial configuration is designed to provide 20MW of RF power into the plasma during 3600s and a duty cycle of up to 25% for heating and (co and counter non-inductive current drive, also used to control the MHD plasma instabilities. The EC system is being procured by 5 domestic agencies plus the ITER Organization (IO. F4E has the largest fraction of the EC procurements, which includes 8 high voltage power supplies (HVPS, 6 gyrotrons, the ex-vessel waveguides (includes isolation valves and diamond windows for all launchers, 4 upper launchers and the main control system. F4E is working with IO to improve the overall design of the EC system by integrating consolidated technological advances, simplifying the interfaces, and doing global engineering analysis and assessments of EC heating and current drive physics and technology capabilities. Examples are the optimization of the HVPS and gyrotron requirements and performance relative to power modulation for MHD control, common qualification programs for diamond window procurements, assessment of the EC grounding system, and the optimization of the launcher steering angles for improved EC access. Here we provide an update on the status of Europe’s contribution to the ITER EC system, and a summary of the global activities underway by F4E in collaboration with IO for the optimization of the subsystems.

  11. Explaining (Missing) Regulator Paradigm Shifts

    DEFF Research Database (Denmark)

    Wigger, Angela; Buch-Hansen, Hubert

    2014-01-01

    of competition regulation is heaving into sight. It sets out to explain this from the vantage point of a critical political economy perspective, which identifies the circumstances under which a crisis can result in a regulatory paradigm shift. Contrasting the current situation with the shift in EC/EU competition...

  12. Gene expression responses linked to reproduction effect concentrations (EC 10,20,50,90 of dimethoate, atrazine and carbendazim, in Enchytraeus albidus.

    Directory of Open Access Journals (Sweden)

    Sara C Novais

    Full Text Available BACKGROUND: Molecular mechanisms of response to pesticides are scarce and information on such responses from soil invertebrates is almost inexistent. Enchytraeus albidus (Oligochaeta is a standard soil ecotoxicology model species for which effects of many pesticides are known on survival, reproduction and avoidance behaviour. With the recent microarray development additional information can be retrieved on the molecular effects. METHODOLOGY/PRINCIPAL FINDINGS: Experiments were performed to investigate the transcription responses of E. albidus when exposed to three pesticides - dimethoate (insecticide, atrazine (herbicide and carbendazim (fungicide - in a range of concentrations that inhibited reproduction by 10%, 20%, 50% and 90% (EC(10, EC(20, EC(50 and EC(90, respectively. The goal of this study was to further identify key biological processes affected by each compound and if dose-related. All three pesticides significantly affected biological processes like translation, regulation of the cell cycle or general response to stress. Intracellular signalling and microtubule-based movement were affected by dimethoate and carbendazim whereas atrazine affected lipid and steroid metabolism (also by dimethoate or carbohydrate metabolism (also by carbendazim. Response to DNA damage/DNA repair was exclusively affected by carbendazim. CONCLUSIONS: Changes in gene expression were significantly altered after 2 days of exposure in a dose-related manner. The mechanisms of response were comparable with the ones for mammals, suggesting across species conserved modes of action. The present results indicate the potential of using gene expression in risk assessment and the advantage as early markers.

  13. Environmental Quality Standards in the EC-Water Framework Directive

    DEFF Research Database (Denmark)

    Jirka, Gerhard H.; Burrows, Richard; Larsen, Torben

    2004-01-01

    quality standards apply is missing in the WFD. The omission will limit its administrative implementation. A clear mixing zone regulation is needed so that the quality objectives of the WFD are not jeopardized. This need is demonstrated using the examples of point source discharges into rivers and coastal...

  14. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG

    NARCIS (Netherlands)

    Yuan, Lei; Sacharidou, Anastasia; Stratman, Amber N.; Le Bras, Alexandra; Zwiers, Peter J.; Spokes, Katherine; Bhasin, Manoj; Shih, Shou-ching; Nagy, Janice A.; Molema, Grietje; Aird, William C.; Davis, George E.; Oettgen, Peter

    2011-01-01

    ERG is a member of the ETS transcription factor family that is highly enriched in endothelial cells (ECs). To further define the role of ERG in regulating EC function, we evaluated the effect of ERG knockdown on EC lumen formation in 3D collagen matrices. Blockade of ERG using siRNA completely inter

  15. 76 FR 42765 - Privacy Act of 1974; Amended System of Records

    Science.gov (United States)

    2011-07-19

    ... and/or other internal mechanisms. Access to records is granted only as authorized by a business line... amendment to its regulation at 31 CFR part 208 (Part 208) (see, 75 FR 80315), which implements 31 U.S.C... of records was last published in its entirety on May 15, 2009, at 74 FR 23012. The altered system...

  16. A Proposed Process for Managing the First Amendment Aspects of Campus Hate Speech.

    Science.gov (United States)

    Kaplan, William A.

    1992-01-01

    A carefully structured process for campus administrative decision making concerning hate speech is proposed and suggestions for implementation are offered. In addition, criteria for evaluating hate speech processes are outlined, and First Amendment principles circumscribing the institution's discretion to regulate hate speech are discussed.…

  17. 75 FR 62592 - Applications and Amendments to Facility Operating Licenses Involving Proposed No Significant...

    Science.gov (United States)

    2010-10-12

    ... amendments to the Renewed Facility Operating Licenses include: (1) The proposed Cyber Security Plan for CCNPP... implement and maintain in effect all provisions of the Nuclear Regulatory Commission-approved Cyber Security... cyber security program. This regulation specifically requires each licensee currently licensed...

  18. 76 FR 34181 - Pistachios Grown in California, Arizona, and New Mexico; Proposed Amendments to Marketing Order

    Science.gov (United States)

    2011-06-13

    ... part 900 (73 FR 49307; August, 21, 2008). The changes to section 18c(17) of the Act and additional... Agricultural Marketing Service 7 CFR Part 983 Pistachios Grown in California, Arizona, and New Mexico; Proposed...: Four amendments to Marketing Agreement and Order No. 983, which regulates the handling of...

  19. 24 CFR 1000.232 - Can an Indian tribe or TDHE amend its IHP?

    Science.gov (United States)

    2010-04-01

    ... its IHP? 1000.232 Section 1000.232 Housing and Urban Development Regulations Relating to Housing and... an Indian tribe or TDHE amend its IHP? Yes. Section 103(c) of NAHASDA specifically provides that a recipient may submit modifications or revisions of its IHP to HUD. Unless the initial IHP...

  20. 77 FR 37305 - Navigation and Navigable Waters; Technical, Organizational, and Conforming Amendments

    Science.gov (United States)

    2012-06-21

    ... Regulations DOT Department of Transportation FR Federal Register TSA Transportation Security Administration..., 116 Stat. 2310 (6 U.S.C. 552(d)); E.O. 12777, 56 FR 54757, 3 CFR, 1991 Comp., p. 351, as amended by E.O. 13286, 68 FR 10619, 3 CFR, 2004 Comp., p. 166; Department of Homeland Security Delegation...

  1. 77 FR 42637 - Navigation and Navigable Waters; Technical, Organizational, and Conforming Amendments; Corrections

    Science.gov (United States)

    2012-07-20

    ... Register of Thursday, June 21, 2012 (77 FR 37305). The regulations related to technical, organizational and... 21, 2012 (77 FR 37305), the Coast Guard published a final rule entitled ``Navigation and Navigable..., Organizational, and Conforming Amendments; Corrections AGENCY: Coast Guard, DHS. ACTION: Correcting...

  2. 76 FR 71872 - Rescission of Outdated Rules and Forms, and Amendments To Correct References

    Science.gov (United States)

    2011-11-21

    ... the Code of Federal Regulations is amended as follows: ] PART 200--ORGANIZATION; CONDUCT AND ETHICS... Act of 1935,'' from the third sentence of the introductory text; 0 b. Removing the phrase ``public...,'' from the first sentence of the introductory text and removing paragraph (f). Sec. 200.30-5 0 5....

  3. 49 CFR 525.11 - Termination of exemption; amendment of alternative average fuel economy standard.

    Science.gov (United States)

    2010-10-01

    ... average fuel economy standard. 525.11 Section 525.11 Transportation Other Regulations Relating to... EXEMPTIONS FROM AVERAGE FUEL ECONOMY STANDARDS § 525.11 Termination of exemption; amendment of alternative average fuel economy standard. (a) Any exemption granted under this part for an affected model year...

  4. 76 FR 78096 - U.S. Advanced Boiling Water Reactor Aircraft Impact Design Certification Amendment

    Science.gov (United States)

    2011-12-16

    ...) inside the reactor building, and (3) well away from the power block. Locations inside the primary..., 2009 (74 FR 62829). On June 12, 2009 (74 FR 28112), the NRC amended its regulations to require.... Rather, the AIA rule's goal is to enhance the facility's inherent robustness at the design stage. The...

  5. Restoration of rare earth mine areas: organic amendments and phytoremediation.

    Science.gov (United States)

    Zhou, Lingyan; Li, Zhaolong; Liu, Wen; Liu, Shenghong; Zhang, Limin; Zhong, Liyan; Luo, Ximei; Liang, Hong

    2015-11-01

    Overexploitation of rare earth mine has caused serious desertification and various environmental issues, and ecological restoration of a mining area is an important concern in China. In this study, experiments involving dry grass landfilling, chicken manure broadcasting, and plant cultivation were carried out to reclaim a rare earth mine area located in Heping County, Guangdong Province, China. The prime focus was to improve soil quality in terms of nutrients, microbial community, enzyme activity, and physicochemical properties so as to reclaim the land. After 2 years of restoration, an increase of organic matter (OM), available potassium (K), available phosphorus (P) levels, and acid phosphatase (ACP) activity and a reduction of the available nitrogen (N) level and urease (URE) activity in soil were achieved compared to the original mined land. The nutrients and enzyme activities in soil with 5 years of restoration were close to or surpass those in the unexploited land as control. The bulk density, total porosity, water holding capacity, pH, and electrical conductivity (EC) of soil were improved, and the number of cultivable microorganisms and the bacterial diversity in soil were greatly increased with time during ecological restoration, especially for surface soil. Furthermore, the artificial vegetation stably grew at the restored mining sites. The results indicated that organic amendments and phytoremediation could ecologically restore the rare earth mining sites and the mined land could finally be planted as farmland.

  6. DISPOSAL OF AGRO-INDUSTRIALS WASTES AS SOIL AMENDMENTS

    Directory of Open Access Journals (Sweden)

    Ali Mekki

    2013-01-01

    Full Text Available We investigated the fertilizing potential of three agro-industrial wastes (Compost (C, Dehydrated Manures (DM and Digestate (D on soil properties, on seeds germination and the plants growth. Results showed that the addition of wastes modified several soil properties as pH, Electrical Conductivity (EC, Water Retention Capacity (WRC and Soil Organic Matter (SOM. Hence, SOM increase from 1.5% in unamended soil to 2, 2.3 and to 3.1% in soils amended with (D, with (DM and with (C respectively. A fast SOM biodegradation was illustrated in presence of compost where we noted a decrease of 20% of initial organic matter content. Besides, wastes improve strongly microbial and respirometric soil activities mainly in presence of DM and D. These same wastes stimulate seeds germination of two standard plants species (Tomato (Lycopersicon esculentum and Alfalfa (Medicago sativa. The growth levels of three cultivated plants species (Wheat (Triticum durum, Sorghum (Sorghum bicolor and Alfalfa (Medicago sativa were enhanced in presence of wastes than those irrigated with water.

  7. Restoration of rare earth mine areas: organic amendments and phytoremediation.

    Science.gov (United States)

    Zhou, Lingyan; Li, Zhaolong; Liu, Wen; Liu, Shenghong; Zhang, Limin; Zhong, Liyan; Luo, Ximei; Liang, Hong

    2015-11-01

    Overexploitation of rare earth mine has caused serious desertification and various environmental issues, and ecological restoration of a mining area is an important concern in China. In this study, experiments involving dry grass landfilling, chicken manure broadcasting, and plant cultivation were carried out to reclaim a rare earth mine area located in Heping County, Guangdong Province, China. The prime focus was to improve soil quality in terms of nutrients, microbial community, enzyme activity, and physicochemical properties so as to reclaim the land. After 2 years of restoration, an increase of organic matter (OM), available potassium (K), available phosphorus (P) levels, and acid phosphatase (ACP) activity and a reduction of the available nitrogen (N) level and urease (URE) activity in soil were achieved compared to the original mined land. The nutrients and enzyme activities in soil with 5 years of restoration were close to or surpass those in the unexploited land as control. The bulk density, total porosity, water holding capacity, pH, and electrical conductivity (EC) of soil were improved, and the number of cultivable microorganisms and the bacterial diversity in soil were greatly increased with time during ecological restoration, especially for surface soil. Furthermore, the artificial vegetation stably grew at the restored mining sites. The results indicated that organic amendments and phytoremediation could ecologically restore the rare earth mining sites and the mined land could finally be planted as farmland. PMID:26139395

  8. Scientific Opinion on the substantiation of health claims related to various microorganisms and changes in bowel function, and digestion and absorption of nutrients (ID 960, 961, 967, 969, 971, 975, 983, 985, 994, 996, 998, 1006, 1014, decreasing potentially pathogenic gastro-intestinal microorganisms (ID 960, 967, 969, 971, 975, 983, 985, 994, 996, 998, 1006, 1014, and stimulation of immunological responses (ID 962, 968, 970, 972, 976, 984, 986, 995, 997, 999, 1007, 1015 (further assessment pursuant to Article 13(1 of Regulation (EC No 1924/2006

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Dietetic Products, Nutrition and Allergies

    2012-08-01

    Full Text Available

    Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA was asked to provide a scientific opinion on health claims pursuant to Article 13 of Regulation (EC No 1924/2006 in the framework of further assessment related to various microorganisms and changes in bowel function, and digestion and absorption of nutrients, decreasing potentially pathogenic gastro-intestinal microorganisms, and stimulation of immunological responses. The food constituents, Bifidobacterium animalis subsp. lactis THT 010801, Bifidobacterium longum subsp. infantis THT 010201, Bifidobacterium longum subsp. longum THT 010301, Bifidobacterium pseudolongum subsp. pseudolongum THT 010501, Lactobacillus casei THT 030401, Lactobacillus gasseri THT 031301, Lactobacillus helveticus THT 031102, Lactobacillus plantarum THT 030701, Lactobacillus plantarum THT 030707, Lactobacillus reuteri THT 030802, Lactobacillus salivarius THT 031001 and Streptococcus thermophilus THT 070102, are sufficiently characterised. The evidence provided did not establish that the proposed claimed effect, stimulation of immunological responses, is a beneficial physiological effect. The references provided for the health claims related to changes in bowel function and decreasing potentially pathogenic gastro-intestinal microorganisms included studies which assessed the effects of food constituents other than the food constituents which are the subject of the claims and/or investigated health outcomes unrelated to the claimed effects. No human studies which investigated the effects of the food constituents on appropriate measures of the claimed effects were provided. On the basis of the data presented, the Panel concludes that a cause and effect relationship has not been established between the consumption of

  9. 78 FR 54321 - Joint Industry Plan; Notice of Filing and Immediate Effectiveness of the Fourth Amendment to the...

    Science.gov (United States)

    2013-09-03

    ...), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025); 62883 (September 10, 2010), 75 FR 56608 (September... be amended, is attached as Exhibit A hereto. Pursuant to Rule 608(b)(3)(iii) under Regulation NMS,\\4... (``Transmittal Letter''). \\4\\ 17 CFR 242.608(b)(3)(iii). I. Rule 608(a) of Regulation NMS A. Purpose of the...

  10. A global inventory of aircraft NO{sub x} emissions (ANCAT/EC 2). A revised inventory (1996) by the ECAC/ANCAT and EC working group

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, R.M. [Great Minister House, London (United Kingdom). Dept. of Transfert London

    1997-12-31

    Results of the ANCAT/EC 2 inventory produced by the European ANCAT/EC emissions inventory group is reported. The base year inventory has been completed and is currently being written up for report publication. The ANCAT/EC 2 inventory in the base year, 1991/92, has accounted for a total fuel burn of 132.5 Tg/yr and a NO{sub x} mass of 1.82 Tg/yr. The civil subsonic fleet average emissions index is EI NO{sub x} 13.9. The inventory has accounted for 80% of the IEA refined jet fuel total for 1992. The forecast 2015 inventory accounts for 289.4 Tg/yr fuel and 3.48 Tg/yr NO{sub x}, increases of 118% and 91% respectively. Both datasets will be reported fully in the next few months. (author) 5 refs.

  11. Upgrading from the Dicon Wiring Management system to IntEC at the Gentilly 2 station

    International Nuclear Information System (INIS)

    The General Electric DICON Wiring Management system supplied to HQ during the construction of G2 is currently being replaced by the stand-alone version of the IntEC software developed by AECL. The reasons for replacing DICON and choosing lntEC are discussed. The different aspects of the two year DICON data conversion project are presented with the problems encountered and the means that were taken to resolve the problems. lntEC has shown our DICON data to be considerably more deficient than we had thought. This has increased the cost and the duration of the conversion process. However, correcting the errors during the conversion process provides us with much more accurate data. This should be viewed as an investment in configuration management. Many potential causes of future errors and potentially critical path delays have been removed. We have chosen to document the detailed procedures for the use of lntEC in our plant using a Windows Help File compiler. This also has been found to be extremely useful as a training tool as well as providing on-line help. The DICON data conversion into lntEC will not be completed until 1996. lntEC is not perfect. However, from what we have up to now, we are satisfied with the conviviality and efficiency of lntEC and with AECL's diligence in constantly aspiring in making it a better product. (author)

  12. Adaptation of the Emotional Contagion Scale (ECS and gender differences within the Greek cultural context

    Directory of Open Access Journals (Sweden)

    Damigos Dimitris

    2008-08-01

    Full Text Available Abstract Background The Emotional Contagion Scale (ECS is a self-report scale used to measure individual differences in susceptibility to converge towards the emotions expressed by others. The main aim of the present paper was to examine the psychometric properties of the Greek translation of the scale. Methods The Greek ECS was completed by 691 undergraduate students (312 males and 379 females. To investigate the factor structure of the ECS, principal components analysis (PCA was used. Results The results showed that a four-factor model was tenable. Regarding homogeneity, the Greek ECS version showed acceptable results for the full scale (α = 0.74 but not for all subscales. Gender differences were also identified concerning the susceptibility to emotional contagion between men and women. Women score significantly higher than men for all the different emotions described by the ECS (love, happiness, sadness except the anger emotion, where there was no significant difference. Conclusion The Greek version of the ECS showed good psychometric properties. It can be used to assess susceptibility to emotional contagion in correlation with psychopathological processes, mood and anxiety disorders primarily. The usefulness of the ECS in the fields of group psychotherapy and health psychology is also under consideration. Further investigation is needed in all these areas.

  13. Recent activities of EC4 in the harmonization of clinical chemistry in the European Union.

    Science.gov (United States)

    Sanders, G T; Jansen, R T; Beastall, G; Gurr, E; Kenny, D; Kohse, K P; Zérah, S

    1999-04-01

    This article describes the recent activities of the European Communities Confederation of Clinical Chemistry (EC4). Main goal of EC4 is harmonization of clinical chemistry in the European Union and Europe. EC4's actions connected to that are training and registration of professionals, and accreditation of laboratories. The 35000 professionals practising clinical chemistry in the EU have different backgrounds (medical, pharmaceutical, science-oriented, veterinary, or microbiological). Thus, for the harmonization of training of clinical chemists, EC4 has published a European Syllabus for Postgraduate Training, and instituted a European Union Register for Clinical Chemists. The Syllabus is an indication of the level of requirements in postgraduate training. The EC4 initiative to implement the European Register for Clinical Chemists is based on the 8 years vocational training necessary to obtain sufficient knowledge in clinical chemistry according to the European Syllabus. A guide to the EC4 Register has been published; registration leads to the title European Clinical Chemist (EurClinChem). The accreditation of laboratories must be based on a total quality management system. EC4 has described guidelines (essential criteria) which it judges appropriate for establishing the quality of medical laboratory service; it does not wish to fulfil the role of an accrediting body. Moreover, a working group has been set up to seek to harmonize the work of national accrediting bodies. Therefore, it is logical that EC4 monitors the activities of the different standardizing bodies that might influence the practice of clinical chemistry in the EU. Finally, some aspects concerning the future strategy of EC4 are brought forward. PMID:10369121

  14. 75 FR 33682 - Export Administration Regulations; Technical Amendments

    Science.gov (United States)

    2010-06-15

    ... most recently by the Notice of August 13, 2009 (74 FR 41325 (August 14, 2009)), has continued the EAR....; E.O. 13222, 66 FR 44025, 3 CFR, 2001 Comp., p. 783; Notice of August 13, 2009, 74 FR 41325 (August... Bureau of Industry and Security 15 CFR Part 766 RIN 0694-AE93 Export Administration...

  15. 76 FR 21809 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2011-04-19

    ... Atlantic Treaty Organization (NATO) that DLA Logistics Information Service records and maintains in the... CAGE codes to identify commercial and Government entities. DoD 4000.25-5-M, Military Standard...

  16. 77 FR 76936 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2012-12-31

    ..., Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General at the following...'' and adding ``datafax (571) 372-6094'' in its place. PART 203--IMPROPER BUSINESS PRACTICES AND PERSONAL.../ CPF'' and adding ``DPAP/CPIC'' in its place. PART 219--SMALL BUSINESS PROGRAMS 219.202-1 0 8....

  17. 77 FR 15681 - Amendments to the HUD Acquisition Regulation (HUDAR)

    Science.gov (United States)

    2012-03-16

    ... for deviation from the HUDAR, updating provisions that address the organizational structure of HUD... obsolete language concerning HUD's former field contracting organizational structure. Paragraph (b)(3) is... legal counsel to reflect the current Departmental organizational structure. The Office of the...

  18. 78 FR 49697 - HUD Acquisition Regulations (HUDAR): Correcting Amendment

    Science.gov (United States)

    2013-08-15

    ... retention. In making the organizational changes specified in the preamble of the December 10, 2012, final... advance notice and solicit comment on this change. Additionally, however, and of equal or more importance... miscellaneous changes, which included, for example, removing obsolete and redundant provisions,...

  19. 77 FR 4228 - Technical Amendments and Corrections to DEA Regulations

    Science.gov (United States)

    2012-01-27

    ... Comprehensive Drug Abuse Prevention and Control Act of 1970, often referred to as the Controlled Substances Act... substances listed in Schedules I and II: (1) Each of the opiates, including its isomers, esters, ethers... in Sec. 1308.12(b)(2) of this chapter; (xiv) Cocaine; and (xv) Ecgonine; (5) Each of the...

  20. 75 FR 35631 - Regulations to Amend the Civil Procedures

    Science.gov (United States)

    2010-06-23

    ... Civil Procedures AGENCY: Office of General Counsel (OGC), National Oceanic and Atmospheric... administrative proceedings for the assessment of civil penalties; suspension, revocation, modification, or denial... principal change removes the requirement that an Administrative Law Judge state good reason(s) for...

  1. 75 FR 13050 - Regulations to Amend the Civil Procedures

    Science.gov (United States)

    2010-03-18

    ... an Administrative Law Judge state good reason(s) for departing from the civil penalty or permit... Civil Procedures AGENCY: Office of General Counsel (OGC), National Oceanic and Atmospheric... administrative proceedings for the assessment of civil penalties; suspension, revocation, modification, or...

  2. 78 FR 5997 - Amendments to National Marine Sanctuary Regulations

    Science.gov (United States)

    2013-01-28

    ...'', ``sanctuary resource'', ``take or taking,'' ''tropical fish,'' and ``vessel.'' ``Benthic community'' would be... the case today. ``Tropical fish'' would be updated by replacing the phrase ``for aquaria purposes... terminology to ``aquarium trade'', which is currently used. This revised definition of ``tropical...

  3. Application of organic amendments to a coastal saline soil in north China: effects on soil physical and chemical properties and tree growth.

    Directory of Open Access Journals (Sweden)

    Linlin Wang

    Full Text Available The ability of the following four organic amendments to ameliorate saline soil in coastal northern China was investigated from April 2010 to October 2012 in a field experiment: green waste compost (GWC, sedge peat (SP, furfural residue (FR, and a mixture of GWC, SP and FR (1∶1∶1 by volume (GSF. Compared to a non-amended control (CK, the amendments, which were applied at 4.5 kg organic matter m(-3, dramatically promoted plant growth; improved soil structure; increased the cation exchange capacity (CEC, organic carbon, and available nutrients; and reduced the salt content, electrical conductivity (EC, and exchangeable sodium percentage (ESP. At the end of the experiment in soil amended with GSF, bulk density, EC, and ESP had decreased by 11, 87, and 71%, respectively, and total porosity and organic carbon had increased by 25 and 96% respectively, relative to the CK. The GSF treatment resulted in a significantly lower Na(++K(+ content than the other treatments. CEC and the contents of available N, P, and K were significantly higher in the GSF-treated soil than in the CK and were the highest in all treatments. The FR treatment resulted in the lowest pH value and Ca(2+ concentration, which decreased by 8% and 39%, respectively, relative to the CK. Overall, the results indicate that a combination of green waste compost, sedge peat and furfural residue (GSF treatment has substantial potential for ameliorating saline soils in the coastal areas of northern China, and it works better than each amendment alone. Utilization of GWC and FR can be an alternative organic amendment to substitute the nonrenewable SP in saline soil amelioration.

  4. 78 FR 44213 - Spring 2013 Semiannual Agenda of Regulations

    Science.gov (United States)

    2013-07-23

    ... Management Plan. 48 Implement the 2010 Shark 0648-BB02 Conservation Act Provisions and Other Regulations in the Atlantic Smoothhound Shark Fishery. 49 Amendment 89 to the Gulf 0648-BB76 of Alaska Groundfish... Rockfish, and Bocaccio. 64 Amending the Atlantic 0648-BC90 Large Whale Take Reduction Plan....

  5. 76 FR 5473 - Technical Corrections to the TTB Regulations

    Science.gov (United States)

    2011-02-01

    ... nonbeverage drawback is available, and this change was incorporated into part 17 by T.D. ATF-379 (61 FR 31412... its regulations. These amendments correct grammatical, spelling and typographical errors, update cross... other non-substantive corrections and clarifications. These amendments do not change the...

  6. Operation of Trades Licensing Office after the amendment of Trades Licensing Act

    OpenAIRE

    Neužilová, Barbora

    2011-01-01

    My work "Operation of Trades Licensing Office after amendement of the Trades Licensing Act" deals with valid legal regulation of the Trade Licensing Act, which the officers follow. My work is divided into two parts. The first part contains the valid legal regulation. Here I analyse not only the Trades Licensing Act, but also the law about Trades Licensing Offices. Further, the practical part follows. At the beginnning of the practical part of my work I describe the operations of the rele...

  7. Bemesting Alstroemeria: Invloed van EC en K:Ca verhoudingin de teelt van Alstroemeria op kokossubstraat

    OpenAIRE

    Helm, van der, F.P.M.; Labrie, C.W.; Mourik, van, J.A.; De, Groot, N.; Voogt, W.

    2013-01-01

    In 2010 is budget beschikbaar gesteld door het Productschap Tuinbouw voor een 2 jaar durend onderzoek om te bepalen wat de juiste verhouding K:Ca bij verschillende EC-niveau’s is gedurende het jaar. Er is een twee jaar durende kasproef uitgevoerd waarin een K:Ca verhouding van 5:1, 1:1 en 1:3 is gerealiseerd bij een EC van 2 (laag) en 3 (hoog) mS/ cm. In het onderzoek gaf de hoge EC op een kokossubstraat bij een K:Ca verhouding van 1:1 of lager betrouwbaar meer productie in stuks en in kilo’s...

  8. 33 CFR 106.415 - Amendment and audit.

    Science.gov (United States)

    2010-07-01

    ... Security Plan (FSP) § 106.415 Amendment and audit. (a) Amendments. (1) Amendments to a Facility Security... duties; and (iii) Be independent of any security measures being audited. (5) If the results of an audit... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Amendment and audit....

  9. Dr-FtsA, an actin homologue in Deinococcus radiodurans differentially affects Dr-FtsZ and Ec-FtsZ functions in vitro.

    Directory of Open Access Journals (Sweden)

    Kruti Modi

    Full Text Available The Deinococcus radiodurans genome encodes homologues of divisome proteins including FtsZ and FtsA. FtsZ of this bacterium (Dr-FtsZ has been recently characterized. In this paper, we study FtsA of D. radiodurans (Dr-FtsA and its involvement in regulation of FtsZ function. Recombinant Dr-FtsA showed neither ATPase nor GTPase activity and its polymerization was ATP dependent. Interestingly, we observed that Dr-FtsA, when compared with E. coli FtsA (Ec-FtsA, has lower affinity for both Dr-FtsZ and Ec-FtsZ. Also, Dr-FtsA showed differential effects on GTPase activity and sedimentation characteristics of Dr-FtsZ and Ec-FtsZ. For instance, Dr-FtsA stimulated GTPase activity of Dr-FtsZ while GTPase activity of Ec-FtsZ was reduced in the presence of Dr-FtsA. Stimulation of GTPase activity of Dr-FtsZ by Dr-FtsA resulted in depolymerization of Dr-FtsZ. Dr-FtsA effects on GTPase activity and polymerization/depolymerisation characteristics of Dr-FtsZ did not change significantly in the presence of ATP. Recombinant E. coli expressing Dr-FtsA showed cell division inhibition in spite of in trans expression of Dr-FtsZ in these cells. These results suggested that Dr-FtsA, although it lacks ATPase activity, is still functional and differentially affects Dr-FtsZ and Ec-FtsZ function in vitro.

  10. Dr-FtsA, an actin homologue in Deinococcus radiodurans differentially affects Dr-FtsZ and Ec-FtsZ functions in vitro.

    Science.gov (United States)

    Modi, Kruti; Misra, Hari S

    2014-01-01

    The Deinococcus radiodurans genome encodes homologues of divisome proteins including FtsZ and FtsA. FtsZ of this bacterium (Dr-FtsZ) has been recently characterized. In this paper, we study FtsA of D. radiodurans (Dr-FtsA) and its involvement in regulation of FtsZ function. Recombinant Dr-FtsA showed neither ATPase nor GTPase activity and its polymerization was ATP dependent. Interestingly, we observed that Dr-FtsA, when compared with E. coli FtsA (Ec-FtsA), has lower affinity for both Dr-FtsZ and Ec-FtsZ. Also, Dr-FtsA showed differential effects on GTPase activity and sedimentation characteristics of Dr-FtsZ and Ec-FtsZ. For instance, Dr-FtsA stimulated GTPase activity of Dr-FtsZ while GTPase activity of Ec-FtsZ was reduced in the presence of Dr-FtsA. Stimulation of GTPase activity of Dr-FtsZ by Dr-FtsA resulted in depolymerization of Dr-FtsZ. Dr-FtsA effects on GTPase activity and polymerization/depolymerisation characteristics of Dr-FtsZ did not change significantly in the presence of ATP. Recombinant E. coli expressing Dr-FtsA showed cell division inhibition in spite of in trans expression of Dr-FtsZ in these cells. These results suggested that Dr-FtsA, although it lacks ATPase activity, is still functional and differentially affects Dr-FtsZ and Ec-FtsZ function in vitro.

  11. 77 FR 69738 - Truth in Lending (Regulation Z)

    Science.gov (United States)

    2012-11-21

    ... Regulation Z on December 22, 2011, and the Bureau's Regulation Z is located at 12 CFR part 1026. 76 FR 79768... PROTECTION 12 CFR Part 1026 Truth in Lending (Regulation Z) AGENCY: Bureau of Consumer Financial Protection...) is publishing a final rule amending the official interpretations for Regulation Z (Truth in...

  12. 75 FR 40720 - IFR Altitudes; Miscellaneous Amendments

    Science.gov (United States)

    2010-07-14

    ... ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does... UNUSABLE. Sec. 95.6424 VOR FEDERAL AIRWAY V424 IS AMENDED TO READ IN PART NAPOLEON, MO VORTAC MACON, MO...

  13. Mass Media and the First Amendment

    Science.gov (United States)

    Hanks, William E.

    1975-01-01

    Discusses five Supreme Court decisions that relate to the First Amendment and freedom of the press. Includes small group decision-making exercises and discussion questions focusing on these interpretations for use in a college speech communication class. (MH)

  14. Preferential regulation of miRNA targets by environmental chemicals in the human genome

    Directory of Open Access Journals (Sweden)

    Wu Xudong

    2011-05-01

    Full Text Available Abstract Background microRNAs (miRNAs represent a class of small (typically 22 nucleotides in length non-coding RNAs that can degrade their target mRNAs or block their translation. Recent disease research showed the exposure to some environmental chemicals (ECs can regulate the expression patterns of miRNAs, which raises the intriguing question of how miRNAs and their targets cope with the exposure to ECs throughout the genome. Results In this study, we comprehensively analyzed the properties of genes regulated by ECs (EC-genes and found miRNA targets were significantly enriched among the EC-genes. Compared with the non-miRNA-targets, miRNA targets were roughly twice as likely to be EC-genes. By investigating the collection methods and other properties of the EC-genes, we demonstrated that the enrichment of miRNA targets was not attributed to either the potential collection bias of EC-genes, the presence of paralogs, longer 3'UTRs or more conserved 3'UTRs. Finally, we identified 1,842 significant concurrent interactions between 407 miRNAs and 497 ECs. This association network of miRNAs-ECs was highly modular and could be separated into 14 interconnected modules. In each module, miRNAs and ECs were closely connected, providing a good method to design accurate miRNA markers for ECs in toxicology research. Conclusions Our analyses indicated that miRNAs and their targets played important roles in cellular responses to ECs. Association analyses of miRNAs and ECs will help to broaden the understanding of the pathogenesis of such chemical components.

  15. The European Coal Market: Will Coal Survive the EC's Energy and Climate Policies?

    International Nuclear Information System (INIS)

    at international coal prices and their competitiveness compared with competing fuels. Chapter 4 provides an overview of EC regulations that are likely to shape the future demand of coal. Chapter 5 gives an overview of CCT and CCS development in Europe, while Chapter 6 presents the outlook of future coal demand and scenarios developed by the International Energy Agency and the European Commission. The second part of the report gives a detailed picture of the three largest European coal markets (Germany, Poland and the United Kingdom). It also looks at the Spanish coal market. Although coal in this country accounts for a small share of total energy consumption, recent austerity measures and their social impact put the sector into the public spotlight. A description of the coal market is given for each country. Then, key developments and issues pertaining to each country and its coal market are discussed. Chapter 7 analyses the impact of the phase-out of nuclear energy in Germany. Chapter 8 provides an overview of Poland's energy policy to 2030 and the CCS road-map prepared by the Bellona Foundation. Chapter 9 focuses on market reform of electricity in the United Kingdom and its impact on coal-fired power generation. Chapter 10 looks at coal subsidies in Spain and the impact of the drastic cut in coal mining subsidies decided by the government in May 2012. Annex 1 explains what the nature coal is and the main differences between steam coal (mainly used in power generation) and coking coal (used in the iron and steel industry). Annex 2 briefly analyses the use of coal in the steel industry. Annex 3 provides some useful unit conversions

  16. Hantavirus Regulation of Type I Interferon Responses

    Directory of Open Access Journals (Sweden)

    Valery Matthys

    2012-01-01

    Full Text Available Hantaviruses primarily infect human endothelial cells (ECs and cause two highly lethal human diseases. Early addition of Type I interferon (IFN to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early interferon induction. PHV replication is blocked in human ECs, but not inhibited in IFN deficient VeroE6 cells and consistent with this, infecting ECs with PHV results in the early induction of IFNβ and an array of interferon stimulated genes (ISGs. In contrast, ANDV, HTNV, NY-1V and TULV hantaviruses, inhibit early ISG induction and successfully replicate within human ECs. Hantavirus inhibition of IFN responses has been attributed to several viral proteins including regulation by the Gn proteins cytoplasmic tail (Gn-T. The Gn-T interferes with the formation of STING-TBK1-TRAF3 complexes required for IRF3 activation and IFN induction, while the PHV Gn-T fails to alter this complex or regulate IFN induction. These findings indicate that interfering with early IFN induction is necessary for hantaviruses to replicate in human ECs, and suggest that additional determinants are required for hantaviruses to be pathogenic. The mechanism by which Gn-Ts disrupt IFN signaling is likely to reveal potential therapeutic interventions and suggest protein targets for attenuating hantaviruses.

  17. 77 FR 14269 - IFR Altitudes; Miscellaneous Amendments

    Science.gov (United States)

    2012-03-09

    ... BILLINGS, MT VORTAC..... W BND 9700 E BND 6400 Sec. 95.681 VOR Federal Airway V81 Is Amended to Read in... Amended to Read in Part REEPO, MT FIX COLUS, MT FIX W BND 9700 ] E BND 7000 COLUS, MT FIX BILLINGS, MT... *BILLINGS, MT VORTAC.... S BND 17000 N BND 6000 *7000--MCA BILLINGS, MT VORTAC, S BND Sec. 95.6320......

  18. Amendment works of the Korean civil code (Property Law)

    OpenAIRE

    Kim, Sang Yong

    2001-01-01

    "The Korean Civil Code is currently in the process of amendment. The government expects to submit a proposal for amending the Civil Code to this year's regular session of the National Assembly. However, considering the extent to which the works for amending the Civil Code being in process by the Civil Code amendment committee have thus far advanced, submission of the proposal for Civil Code amendment within this year’s regular session of the National Assembly can be considered ...

  19. Agricultural price and income policy in the EC : alternative policies and their implications

    NARCIS (Netherlands)

    Meester, G.

    1980-01-01

    Alternative forms of income policy without direct supply control. Alternative forms of income policy with direct supply control: quota arrangements. The influence of EC policy on the world market prices of agricultural produce

  20. Search for $\\beta^+$EC and ECEC processes in $^{112}$Sn

    CERN Document Server

    Barabash, A S; Nachab, A; Konovalov, S I; Umatov, V

    2009-01-01

    Limits on $\\beta^+$EC (here EC denotes electron capture) and ECEC processes in $^{112}$Sn have been obtained using a 380 cm$^3$ HPGe detector and an external source consisting of 53.355 g enriched tin (94.32% of $^{112}$Sn). A limit with 90% C.L. on the $^{112}$Sn half-life of $4.7\\times 10^{20}$ y for the ECEC(0$\

  1. User illusion: ideological construction of ‘user-generated content’ in the EC consultation on copyright

    OpenAIRE

    Erickson, Kristofer

    2014-01-01

    Recent policy consultations by the UK Intellectual Property Office, the US Patent and Trademark Office and the European Commission (EC) have highlighted the importance of user-generated content in debates to reform copyright. User-generated content (UGC) – often combining existing copyright material with transformative creativity – remains a contested terrain, with no clear or widely accepted definition. This paper examines how various stakeholders in the 2014 EC consultation on c...

  2. User illusion: ideological construction of ‘user-generated content’ in the EC consultation on copyright

    OpenAIRE

    Erickson, Kristofer

    2014-01-01

    Recent policy consultations by the UK Intellectual Property Office, the US Patent and Trademark Office and the European Commission (EC) have highlighted the importance of user-generated content in debates to reform copyright. User-generated content (UGC) – often combining existing copyright material with transformative creativity – remains a contested terrain, with no clear or widely accepted definition. This paper examines how various stakeholders in the 2014 EC consultation on copyright att...

  3. 76 FR 54078 - Cotton Board Rules and Regulations: Adjusting Supplemental Assessment on Imports

    Science.gov (United States)

    2011-08-31

    ... Agricultural Marketing Service 7 CFR Part 1205 Cotton Board Rules and Regulations: Adjusting Supplemental... Agricultural Marketing Service (AMS) is amending the Cotton Board Rules and Regulations by updating the value... Register on December 10, 1991, (56 FR 64470). A proposed rule implementing the amended Order was...

  4. Can postictal suppression of the perforant path - fascia dentata responses account for the ECS-induced anterograde amnesia in rats?

    Science.gov (United States)

    Peréz-Saad, H; Valousková, V; Bures, J

    1984-07-15

    Electroconvulsive shock (ECS) decreases fascia dentata responses to entorhinal stimulation by 50% in unanesthetized rats. Synaptic potentials and population spikes return to pre-ECS level during 1 h and 3 h, respectively. This recovery rate is compared with the dynamics of ECS-induced anterograde amnesia.

  5. Cooperative Fuzzy Games Approach to Setting Target Levels of ECs in Quality Function Deployment

    Directory of Open Access Journals (Sweden)

    Zhihui Yang

    2014-01-01

    Full Text Available Quality function deployment (QFD can provide a means of translating customer requirements (CRs into engineering characteristics (ECs for each stage of product development and production. The main objective of QFD-based product planning is to determine the target levels of ECs for a new product or service. QFD is a breakthrough tool which can effectively reduce the gap between CRs and a new product/service. Even though there are conflicts among some ECs, the objective of developing new product is to maximize the overall customer satisfaction. Therefore, there may be room for cooperation among ECs. A cooperative game framework combined with fuzzy set theory is developed to determine the target levels of the ECs in QFD. The key to develop the model is the formulation of the bargaining function. In the proposed methodology, the players are viewed as the membership functions of ECs to formulate the bargaining function. The solution for the proposed model is Pareto-optimal. An illustrated example is cited to demonstrate the application and performance of the proposed approach.

  6. Cooperative fuzzy games approach to setting target levels of ECs in quality function deployment.

    Science.gov (United States)

    Yang, Zhihui; Chen, Yizeng; Yin, Yunqiang

    2014-01-01

    Quality function deployment (QFD) can provide a means of translating customer requirements (CRs) into engineering characteristics (ECs) for each stage of product development and production. The main objective of QFD-based product planning is to determine the target levels of ECs for a new product or service. QFD is a breakthrough tool which can effectively reduce the gap between CRs and a new product/service. Even though there are conflicts among some ECs, the objective of developing new product is to maximize the overall customer satisfaction. Therefore, there may be room for cooperation among ECs. A cooperative game framework combined with fuzzy set theory is developed to determine the target levels of the ECs in QFD. The key to develop the model is the formulation of the bargaining function. In the proposed methodology, the players are viewed as the membership functions of ECs to formulate the bargaining function. The solution for the proposed model is Pareto-optimal. An illustrated example is cited to demonstrate the application and performance of the proposed approach.

  7. Overview of the ITER EC H and CD system and its capabilities

    International Nuclear Information System (INIS)

    The Electron Cyclotron (EC) system for the ITER tokamak is designed to inject ≥20 MW RF power into the plasma for Heating and Current Drive (H and CD) applications. The EC system consists of up to 26 gyrotrons (between 1 and 2 MW each), the associated power supplies, 24 transmission lines and 5 launchers. The EC system has a diverse range of applications including central heating and current drive, current profile tailoring and control of plasma magneto-hydrodynamic (MHD) instabilities such as the sawtooth and neoclassical tearing modes (NTMs). This diverse range of applications requires the launchers to be capable of depositing the EC power across nearly the entire plasma cross section. This is achieved by two types of antennas: an equatorial port launcher (capable of injecting up to 20 MW from the plasma axis to mid-radius) and four upper port launchers providing access from inside of mid radius to near the plasma edge. The equatorial launcher design is optimized for central heating, current drive and profile tailoring, while the upper launcher should provide a very focused and peaked current density profile to control the plasma instabilities. The overall EC system has been modified during the past 3 years taking into account the issues identified in the ITER design review from 2007 and 2008 as well as integrating new technologies. This paper will review the principal objectives of the EC system, modifications made during the past 2 years and how the design is compliant with the principal objectives.

  8. Cooperative fuzzy games approach to setting target levels of ECs in quality function deployment.

    Science.gov (United States)

    Yang, Zhihui; Chen, Yizeng; Yin, Yunqiang

    2014-01-01

    Quality function deployment (QFD) can provide a means of translating customer requirements (CRs) into engineering characteristics (ECs) for each stage of product development and production. The main objective of QFD-based product planning is to determine the target levels of ECs for a new product or service. QFD is a breakthrough tool which can effectively reduce the gap between CRs and a new product/service. Even though there are conflicts among some ECs, the objective of developing new product is to maximize the overall customer satisfaction. Therefore, there may be room for cooperation among ECs. A cooperative game framework combined with fuzzy set theory is developed to determine the target levels of the ECs in QFD. The key to develop the model is the formulation of the bargaining function. In the proposed methodology, the players are viewed as the membership functions of ECs to formulate the bargaining function. The solution for the proposed model is Pareto-optimal. An illustrated example is cited to demonstrate the application and performance of the proposed approach. PMID:25097884

  9. A Study on Partnering Mechanism in B to B EC Server for Global Supply Chain Management

    Science.gov (United States)

    Kaihara, Toshiya

    B to B Electronic Commerce (EC) technology is now in progress and regarded as an information infrastructure for global business. As the number and diversity of EC participants grows at the agile environment, the complexity of purchasing from a vast and dynamic array of goods and services needs to be hidden from the end user. Putting the complexity into the EC system instead means providing flexible auction server for enabling commerce within different business units. Market mechanism could solve the product distribution problem in the auction server by allocating the scheduled resources according to market prices. In this paper, we propose a partnering mechanism for B to B EC with market-oriented programming that mediates amongst unspecified various companies in the trade, and demonstrate the applicability of the economic analysis to this framework after constructing a primitive EC server. The proposed mechanism facilitates sophisticated B to B EC, which conducts a Pareto optimal solution for all the participating business units in the coming agile era.

  10. Statistical strategies for averaging EC50 from multiple dose-response experiments.

    Science.gov (United States)

    Jiang, Xiaoqi; Kopp-Schneider, Annette

    2015-11-01

    In most dose-response studies, repeated experiments are conducted to determine the EC50 value for a chemical, requiring averaging EC50 estimates from a series of experiments. Two statistical strategies, the mixed-effect modeling and the meta-analysis approach, can be applied to estimate average behavior of EC50 values over all experiments by considering the variabilities within and among experiments. We investigated these two strategies in two common cases of multiple dose-response experiments in (a) complete and explicit dose-response relationships are observed in all experiments and in (b) only in a subset of experiments. In case (a), the meta-analysis strategy is a simple and robust method to average EC50 estimates. In case (b), all experimental data sets can be first screened using the dose-response screening plot, which allows visualization and comparison of multiple dose-response experimental results. As long as more than three experiments provide information about complete dose-response relationships, the experiments that cover incomplete relationships can be excluded from the meta-analysis strategy of averaging EC50 estimates. If there are only two experiments containing complete dose-response information, the mixed-effects model approach is suggested. We subsequently provided a web application for non-statisticians to implement the proposed meta-analysis strategy of averaging EC50 estimates from multiple dose-response experiments.

  11. Effect of serum concentration on adhesion of monocytic THP-1 cells onto cultured EC monolayer and EC-SMC Co-culture

    Institute of Scientific and Technical Information of China (English)

    Li-jie FAN; Take-shi KARINO

    2008-01-01

    Background:The adhesion of monocytes to the endothelium following accumulation oflow-density lipoprotein(LDL) in subendothelial spaces is an important step in the development of intimal hyperplasia in arterially implanted vein grafts and atherosclerosis in both animals and humans.However.it iS not well known how serum factors affect the adhesion of monocytes.Methods:We have studied the efrect of fetal calf serum(FCS).which we considered a source of LDL.on the adhesion of monocytes to endothelial cells(Ecs)by using human monocytic THP-1 cells and both a monolayer of cultured bovine aortic endothelial cells(EC monoculture)and a co-culture with bovine aortic smooth muscle cells(EC-SMC co-culture).Results:It was found that the addition of FCS to the medium greatly affected the adhesion of THP-1 cells,and the higher the concentration of FCS in the medium,the greater the adhesion of THP-1 cells to endothelial cells.Adhesion of THP-1 cells to an EC-SMC co-culture Was approximately twofold greater than that to an EC monoculture,and after adhering to endothelial cells,many THP-1 cells transmigrated into the layer of smooth muscle cells.Conclusion:The results suggest that the elevation of the LDL(cholesterol)level in blood provides a favorable condition for the development of intimal hyperplasia and atherosclerosis by promoting the adhesion of monocytcs to the endothelium and their subsequent migration into subendothelial spaces.

  12. 78 FR 45168 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-07-26

    ... of Energy (DOE) published a proposed rulemaking in the Federal Register (78 FR 35195) to amend the Department of Energy Acquisition Regulation (DEAR) to add export control requirements applicable to the... Parts 925, 952 and 970 RIN 1991-AB99 Acquisition Regulations: Export Control AGENCY: Department...

  13. 76 FR 5482 - Belarus Sanctions Regulations

    Science.gov (United States)

    2011-02-01

    .... 2461 note); Pub. L. 110-96, 121 Stat. 1011 (50 U.S.C. 1705 note); E.O. 13405, 71 FR 35485; 3 CFR, 2007... Office of Foreign Assets Control 31 CFR Part 548 Belarus Sanctions Regulations AGENCY: Office of Foreign... Assets Control (``OFAC'') is amending the Belarus Sanctions Regulations in the Code of...

  14. 76 FR 35740 - North Korea Sanctions Regulations

    Science.gov (United States)

    2011-06-20

    ... Office of Foreign Assets Control 31 CFR Part 510 North Korea Sanctions Regulations AGENCY: Office of... Foreign Assets Control (``OFAC'') is amending the North Korea Sanctions Regulations to implement Executive... (50 U.S.C. 1601- 1651) (the ``NEA''), issued Executive Order 13466 (73 FR 36787, June 27, 2008)...

  15. EC Research Contribution to Decision-making Processes Relevant to Severe Accident Management

    International Nuclear Information System (INIS)

    As a result of the two well-known civil nuclear accidents and of the consequent increase in safety requirements, the need to properly assess severe accident (SA) scenarios for present and future nuclear power plants (going beyond the traditional three-level defence-in-depth strategy) became evident. In this line, various research activities were launched and are performed within the Euratom Framework Programmes, in particular the completed Fourth one (F P-4, 1994-1998) and the present Fifth one (FP-5, 1998-2002). The initial orientation of the EC research activities was mainly focused on improving the understanding of the phenomena and mechanisms involved in such accidents, in order to contribute to prevent possible final radioactivity releases. A consensus on how to model those SA phenomena in accident safety analyses by means of specific tools (SA codes developed, verified and validated through experimental results provided) is reasonably advanced. Currently, the EC research activities related to severe accidents are balanced between a twofold approach aimed at assessing the risks related with severe accident scenarios and to support the development of severe accident management (SAM) strategies, together with the optimisation of backfitting measures for existing reactors or specific designs for future nuclear power plants. This new orientation is confronting difficulties, inherent to the phenomenological character of several research activities, which make a direct application of the results into SAM measures premature in some cases. In this regard, this paper presents a series of ten selected FP-5 projects with emphasis placed on the applicability of research results towards SAM strategies to be used by decision-makers amongst utilities, the nuclear industry in particular designers, and regulators. The majority of them also contain -further to the SAM approach- supporting elements focused on risk assessment. The revised programme of the key action 'Nuclear

  16. 76 FR 8989 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2011-02-16

    ... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... to amend the Federal Acquisition Regulation (FAR) to update references to authoritative accounting standards owing to the Financial Accounting Standards Board's (FASB's) Accounting Standards...

  17. Spatial and Temporal Variations of EC and OC Aerosol Combustion Sources in a Polluted Metropolitan Area

    Science.gov (United States)

    Mouteva, G.; Randerson, J. T.; Fahrni, S.; Santos, G.; Bush, S. E.; Ehleringer, J. R.; Czimczik, C. I.

    2015-12-01

    Anthropogenic emissions of carbonaceous aerosols are a major component of fine air particulate matter (PM2.5) in polluted metropolitan areas and in the global atmosphere. Elemental (EC) and organic carbon (OC) aerosols influence Earth's energy balance by means of direct and indirect pathways and EC has been suggested as a better indicator of public health impacts from combustion-related sources than PM mass. Quantifying the contribution of fossil fuel and biomass combustion to the EC and OC emissions and their temporal and spatial variations is critical for developing efficient legislative air pollution control measures and successful climate mitigation strategies. In this study, we used radiocarbon (14C) to separate and quantify fossil and biomass contributions to a time series of EC and OC collected at 3 locations in Salt Lake City (SLC). Aerosol samples were collected on quartz fiber filters and a modified OC/EC analyzer was used with the Swiss_4S protocol to isolate and trap the EC fraction. Together with the total carbon (TC) content of the samples, the EC was analyzed for its 14C content with accelerator mass spectrometry. The 14C of OC was derived as a mass balance difference between TC and EC. EC had an annual average fraction modern of 0.13±0.06 and did not vary significantly across seasons. OC had an annual average FM of 0.49±0.13, with the winter mean (0.43±0.11) lower than the summer mean (0.64±0.13) at the 5% significance level. While the 3 stations were chosen to represent a variety of environmental conditions within SLC, no major differences in this source partitioning were observed between stations. During winter, the major sources of air pollutants in SLC are motor vehicles and wood stove combustion and determining their relative contributions has been the subject of debate. Our results indicated that fossil fuels were the dominant source of carbonaceous aerosols during winter, contributing 87% or more of the total EC mass and 40-75% of the OC

  18. EC-sponsored research activities on innovative passive safety systems

    International Nuclear Information System (INIS)

    On April 26th 1994, the European Union (EU) adopted via a Council Decision a EURATOM Multiannual Programme for community activities in the field of Nuclear Fission Safety (NFS) Research for the period 1994 to 1998. An area of work having, as an objective, to 'explore innovative approaches' to improve the safety of future and existing reactors, was introduced in this programme. Most of the projects selected in this area, which have been grouped under a common cluster known as 'INNO', are currently being carried out on a 'cost-shared' basis, i.e. contribution of the European Commission is up to 50% of the total cost. At present, the 'INNO' cluster is composed of 10 projects in which 25 different organisations, representing research centres, universities, regulators, utilities and vendors from 7 EU member states and Switzerland, are involved. These projects are proving to be an efficient means to gain the necessary phenomenological knowledge and to solve the challenging problems, many times of generic nature, posed among others by the characteristically small driving forces of the systems studied and by the lack of really prototypical test facilities. (author)

  19. Immobilization of pentachlorophenol in soil using carbonaceous material amendments

    Energy Technology Data Exchange (ETDEWEB)

    Wen Bei [State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing Road, Haidian District, Beijing 100085 (China)], E-mail: bwen@rcees.ac.cn; Li Ruijuan; Zhang Shuzhen [State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing Road, Haidian District, Beijing 100085 (China); Shan Xiaoquan [State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing Road, Haidian District, Beijing 100085 (China)], E-mail: xiaoquan@rcees.ac.cn; Fang Jing; Xiao Ke [State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing Road, Haidian District, Beijing 100085 (China); Khan, Shahamat U. [Department of Chemistry and Biochemistry, MSN 3E2, George Mason University, 4400 University Drive, Fairfax, VA 22030-4444 (United States)

    2009-03-15

    In this study, three pentachlorophenol (PCP) laboratory-spiked and one field-contaminated soil were amended with 2.0% char, humic acid (HA) and peat, respectively. The amended soils were aged for either 7 or 250 days. After amendment, CaCl{sub 2} extractability of PCP was significantly decreased. Desorption kinetics indicated that the proposed amendment could lead to a strong binding and slow desorption of PCP in soils. Amendment with char reduced the bioaccumulation factor (BAF) of PCP most significantly for earthworms (Eisenia fetida) in all soils studied. The results of both physicochemical and biological tests suggested that amendment reduced PCP bioavailability quickly and enduringly, implying that carbonaceous material amendment, especially char amendment, was a potentially attractive in situ remediation method for sequestration of PCP in contaminated soil. - Carbonaceous material amendment was a potential in situ remediation method for pentachlorophenol contaminated soil.

  20. Screening of preservatives by HPLC-PDA-ESI/MS: A focus on both allowed and recently forbidden compounds in the new EU cosmetics regulation.

    Science.gov (United States)

    Lecce, Raffaele; Regazzoni, Luca; Mustazza, Carlo; Incarnato, Giampaolo; Porrà, Rita; Panusa, Alessia

    2016-06-01

    Commission regulation (EU) No 358/2014 amending the new regulation (EC) No 1223/2009 on cosmetics has prohibited the use of isopropyl-, isobutyl-, phenyl-, benzyl- and pentylparaben. Furthermore, Commission regulation (EU) No 1004/2014 has lowered the maximum permitted concentration of butyl- and propylparaben in cosmetics and it has also banned them in leave-on products designed for application on the nappy area of children under three years of age. A HPLC-PDA-ESI/MS method has been developed herein for the detection of seventeen preservatives, both the most utilised and the recently forbidden by the new EU regulations. The separation of these compounds, including benzoic acid and its derivatives in a 1.10 - 3.04 log Pow range, has been performed with a gradient elution on a Symmetry(®) C18 column (250×4.6mm i.d., particle size 5μm) with water and acetonitrile (0.1% formic acid) as mobile phase. Quantification has been carried out by HPLC-PDA. The method has been validated and successfully applied to the analysis of a large number of cosmetics with different functions like rinse-off and leave-on, or composition like skin, hair, face and oral products. PMID:27055177

  1. Removing the "Silencer": Coverage and Protection of Physician Speech Under the First Amendment.

    Science.gov (United States)

    Weiss, Ryan T

    2016-01-01

    The physician-patient relationship rests on a bedrock of trust. Without trust, patients--and for that matter, physicians--are less willing to divulge information critical to providing accurate medical diagnoses and treatments. The state of Florida seemingly ignored this when its legislature, with support from the National Rifle Association and other pro-gun advocates, enacted the Firearm Owners Privacy Act (FOPA), a statute that restricts physicians from questioning their patients about firearm ownership. In Wollschlaeger v. Governor of Florida, the United States Court of Appeals for the Eleventh Circuit held that FOPA did not regulate physician speech but, instead, regulated physician conduct. As such, the law was exempted from First Amendment scrutiny. But almost one year to the day after publishing its first Wollschlaeger opinion, the Eleventh Circuit sua sponte vacated its original opinion and substituted in its place a brand new opinion--one holding that FOPA was subject to First Amendment scrutiny, but nonetheless passed constitutional muster. This Note uses the diverging Wollschlaeger opinions as a vehicle to analyze the First Amendment's coverage and protection of physician speech. Specifically, it argues that an uninhibited line of communication is required to protect the trust necessary for an effective physician-patient relationship. This logical underpinning leads to the conclusion that the First Amendment presumptively covers physician speech and, furthermore, that physician speech should be subject to intermediate scrutiny--a level of scrutiny that FOPA cannot meet. PMID:26817040

  2. Application of SUPCON ECS-700 in reel%中控ECS-700在卷纸机中的应用

    Institute of Scientific and Technical Information of China (English)

    孙振华; 黄杰; 黄文君

    2014-01-01

    DCS在造纸工业得到较广泛的应用,进一步开发与应用仍具有十分重要的意义。本文结合当前造纸行业卷纸机自动控制工艺的要求及实例,介绍了SUPCON ECS-700卷纸机自动控制方案,该系统功能强大、界面友好、组态方便、实际效果良好。%DCS is widely used in paper industry, and the further investigation is still highly signiifcant. In this paper was introduced the speciifc applications of SUPCON ECS-700 in automatic reel in paer machines, which has the characterixtics of powerfull function, interface frendship, convenent conifguration and good effectiveness.

  3. Tailored graphitized soot as reference material for EC/OC measurement validation

    Directory of Open Access Journals (Sweden)

    O. Popovicheva

    2011-05-01

    Full Text Available The lack of standard reference materials for calibrating, troubleshooting and intercomparing techniques that measure the composition of black carbon, commonly referred to as soot, has been a major obstacle that hinders improved understanding of how climate and health is impacted by this ubiquitous component of the atmosphere. A different approach is offered here as a means of constructing precisely controlled material with fractions of organic carbon (OC on the surface of elemental carbon (EC whose structure reflects that of the combustion produced particles found in the atmosphere. The proposed soot reference material (SRM uses EC as a basis substrate for surface coatings of organic compounds that are representative of the main classes of organics identified in the coverage of soot produced by fossil fuel burning. A number of methods are used to demonstrate the quality and stability of the reference EC and SRM. Comparison of the nominal fraction of OC deposited on the EC substrate with the fraction measured with thermal/optical analysis (TOA shows excellent agreement. Application of this type of reference material for evaluating the different methods of carbon analysis may help resolve differences that currently exist between comparable measurement techniques when trying to separate OC and EC from ambient samples.

  4. A Common Polymorphism in EC-SOD Affects Cardiopulmonary Disease Risk by Altering Protein Distribution

    Science.gov (United States)

    Hartney, John M.; Stidham, Timothy; Goldstrohm, David A.; Oberley-Deegan, Rebecca E.; Weaver, Michael R.; Valnickova-Hansen, Zuzana; Scavenius, Carsten; Benninger, Richard K.P.; Leahy, Katelyn F.; Johnson, Richard; Gally, Fabienne; Kosmider, Beata; Zimmermann, Angela K.; Enghild, Jan J.; Nozik-Grayck, Eva; Bowler, Russell P.

    2014-01-01

    Background The enzyme extracellular superoxide dismutase (EC-SOD; SOD3) is a major antioxidant defense in lung and vasculature. A nonsynonomous single nucleotide polymorphism (SNP) in EC-SOD (rs1799895) leads to an arginine to glycine (Arg->Gly) amino acid substitution at position 213 (R213G) in the heparin-binding domain (HBD). In recent human genetic association studies, this SNP attenuates the risk of lung disease, yet paradoxically increases the risk of cardiovascular disease. Methods and Results Capitalizing on the complete sequence homology between human and mouse in the HBD, we created an analogous R213G SNP knockin mouse. The R213G SNP did not change enzyme activity, but shifted the distribution of EC-SOD from lung and vascular tissue to extracellular fluid (e.g. bronchoalveolar lavage fluid (BALF) and plasma). This shift reduces susceptibility to lung disease (lipopolysaccharide-induced lung injury) and increases susceptibility to cardiopulmonary disease (chronic hypoxic pulmonary hypertension). Conclusions We conclude that EC-SOD provides optimal protection when localized to the compartment subjected to extracellular oxidative stress: thus, the redistribution of EC-SOD from the lung and pulmonary circulation to the extracellular fluids is beneficial in alveolar lung disease but detrimental in pulmonary vascular disease. These findings account for the discrepant risk associated with R213G in humans with lung diseases compared with cardiovascular diseases. PMID:25085920

  5. Merits of online electrochemistry liquid sample desorption electrospray ionization mass spectrometry (EC/LS DESI MS).

    Science.gov (United States)

    Looi, Wen Donq; Brown, Blake; Chamand, Laura; Brajter-Toth, Anna

    2016-03-01

    A new online electrochemistry/liquid sample desorption electrospray ionization mass spectrometry (EC/LS DESI MS) system with a simple electrochemical thin-layer flow-through cell was developed and tested using N,N-dimethyl-p-phenylenediamine (DMPA) as a model probe. Although oxidation of DMPA is observed as a result of ionization of LS in positive ion mode LS DESI, application of voltage to the online electrochemical (EC) cell in EC/LS DESI MS increases yields of oxidation products. An advantage of LS DESI MS is its sensitivity in aqueous electrolyte solutions, which improves efficiency of electrochemical reactions in EC/LS DESI MS. In highly conductive low pH aqueous buffer solutions, oxidation efficiency is close to 100%. EC/ESI MS typically requires mixed aqueous/organic solvents and low electrolyte concentrations for efficient ionization in MS, limiting efficiency of electrochemistry online with MS. Independently, the results verify higher electrochemical oxidation efficiency during positive mode ESI than during LS DESI.

  6. Merits of online electrochemistry liquid sample desorption electrospray ionization mass spectrometry (EC/LS DESI MS).

    Science.gov (United States)

    Looi, Wen Donq; Brown, Blake; Chamand, Laura; Brajter-Toth, Anna

    2016-03-01

    A new online electrochemistry/liquid sample desorption electrospray ionization mass spectrometry (EC/LS DESI MS) system with a simple electrochemical thin-layer flow-through cell was developed and tested using N,N-dimethyl-p-phenylenediamine (DMPA) as a model probe. Although oxidation of DMPA is observed as a result of ionization of LS in positive ion mode LS DESI, application of voltage to the online electrochemical (EC) cell in EC/LS DESI MS increases yields of oxidation products. An advantage of LS DESI MS is its sensitivity in aqueous electrolyte solutions, which improves efficiency of electrochemical reactions in EC/LS DESI MS. In highly conductive low pH aqueous buffer solutions, oxidation efficiency is close to 100%. EC/ESI MS typically requires mixed aqueous/organic solvents and low electrolyte concentrations for efficient ionization in MS, limiting efficiency of electrochemistry online with MS. Independently, the results verify higher electrochemical oxidation efficiency during positive mode ESI than during LS DESI. PMID:26886744

  7. Suitability of marginal biomass-derived biochars for soil amendment.

    Science.gov (United States)

    Buss, Wolfram; Graham, Margaret C; Shepherd, Jessica G; Mašek, Ondřej

    2016-03-15

    The term "marginal biomass" is used here to describe materials of little or no economic value, e.g. plants grown on contaminated land, food waste or demolition wood. In this study 10 marginal biomass-derived feedstocks were converted into 19 biochars at different highest treatment temperatures (HTT) using a continuous screw-pyrolysis unit. The aim was to investigate suitability of the resulting biochars for land application, judged on the basis of potentially toxic element (PTE) concentration, nutrient content and basic biochar properties (pH, EC, ash, fixed carbon). It was shown that under typical biochar production conditions the percentage content of several PTEs (As, Al, Zn) and nutrients (Ca, Mg) were reduced to some extent, but also that biochar can be contaminated by Cr and Ni during the pyrolysis process due to erosion of stainless steel reactor parts (average+82.8% Cr, +226.0% Ni). This can occur to such an extent that the resulting biochar is rendered unsuitable for soil application (maximum addition +22.5 mg Cr kg(-1) biochar and +44.4 mg Ni kg(-1) biochar). Biomass grown on land heavily contaminated with PTEs yielded biochars with PTE concentrations above recommended threshold values for soil amendments. Cd and Zn were of particular concern, exceeding the lowest threshold values by 31-fold and 7-fold respectively, despite some losses into the gas phase. However, thermal conversion of plants from less severely contaminated soils, demolition wood and food waste anaerobic digestate (AD) into biochar proved to be promising for land application. In particular, food waste AD biochar contained very high nutrient concentrations, making it interesting for use as fertiliser. PMID:26789369

  8. A Critique of the Unemployment Insurance Amendment Bill, 2015

    Directory of Open Access Journals (Sweden)

    Marius Olivier

    2015-12-01

    Full Text Available The contribution critically reflects on the proposed amendments to the Unemployment Insurance Act Act 63 of 2001 (the UIA / the Act, introduced via the provisions of the Unemployment Insurance Amendment Bill of 2015 (B25-2015. Several shortcomings and deficiencies are addressed and improvements introduced by the proposed amending legislation, including the extension of coverage to a wider range of beneficiaries, the extension of the period of benefits (to a maximum of 365 days, the increase of the rate of maternity benefits of a (female contributor's earnings, the adjustment of the accrual rate of a contributor's duration of benefits from 1 day for every 6 days of employment to 1 day for every 5 days of employment, and some attempt to provide for employment retention and the re-entry of unemployed contributors into the labour market. And yet, despite these important contributions to the development of unemployment insurance in South Africa, several matters appearing from the Bill point towards inconsistent, inadequate and inappropriate treatment of core elements of the unemployment insurance system. Recommendations have been made to address these matters, which among others relate to: •\tThe insufficient alignment of the UIA with ILO, UN and SADC standards in key areas of concern; •\tUnclear or absent provisions in relation to the coverage and/or application of the UIA in relation to public servants, migrant workers, and the self- and informally employed; •\tInadequate provision for employment promotion, the prevention, combating and reduction of unemployment, and reintegration into employment; •\tInappropriate provisions relating to benefit rates and periods, among others concerning the Minister's power to set/amend the Income Replacement Rate and to vary the benefit period by regulation; •\tInconsistent and discriminatory provisions requiring a 13-week qualifying period for accessing maternity benefits; •\tInappropriate provisions

  9. 78 FR 10269 - National Primary Drinking Water Regulations: Revisions to the Total Coliform Rule

    Science.gov (United States)

    2013-02-13

    ... environmental stresses such as lack of nutrients, and water treatments such as chlorine disinfection, in a...--Code of Federal Regulations COI--Cost of Illness CWS--Community Water System DBP--Disinfection Byproduct DWC--Drinking Water Committee EA--Economic Analysis EC-MUG--EC Medium with MUG EPA--United...

  10. Non-medical application of radioactive materials or ionizing radiation. German legal regulations; Die Anwendung radioaktiver Stoffe oder ionisierender Strahlung ausserhalb der Medizin. Deutsche Rechtsvorschriften

    Energy Technology Data Exchange (ETDEWEB)

    Huhn, Walter [Ministerium fuer Arbeit, Integration und Soziales NRW, Duesseldorf (Germany); Lorenz, Bernd [Lorenz Consulting, Essen (Germany)

    2016-05-01

    Non-medical imaging is regulated in Germany since the 2011 radiation protection law amendment and the simultaneous X-ray regulation amendment based on the Euratom guideline 96/29. The regulations contain lists with justified and non-justified activities.

  11. Regulation of the galanin system by repeated electroconvulsive seizures in mice

    DEFF Research Database (Denmark)

    Christiansen, S H; Woldbye, D P D

    2010-01-01

    . The neuropeptide galanin exerts antiepileptic and antidepressant-like effects and has also been implicated in the pathophysiology of depression. To explore a potential role of galanin in working mechanisms of ECS, the present study examined effects of repeated ECS on the galanin system using QRT-PCR, in situ......]galanin receptor binding in the piriform cortex, hippocampus, and amygdala was found to be significantly down-regulated. These data show that the galanin system is regulated by repeated ECS in a number of brain regions implicated in seizure regulation and depression. These changes may play a role...

  12. EC-FORC: A New Cyclic Voltammetry Based Method for Examining Phase Transitions and Predicting Equilibrium

    CERN Document Server

    Hamad, Ibrahim Abou; Novotny, Mark A; Rikvold, Per Arne

    2007-01-01

    We propose a new, cyclic-voltammetry based experimental technique that can not only differentiate between discontinuous and continuous phase transitions in an adsorbate layer, but also quite accurately recover equilibrium behavior from dynamic analysis of systems with a continuous phase transition. The Electrochemical first-order reversal curve (EC-FORC) diagram for a discontinuous phase transition (nucleation and growth), such as occurs in underpotential deposition, is characterized by a negative region, while such a region does not exist for a continuous phase transition, such as occurs in the electrosorption of Br on Ag(100). Moreover, for systems with a continuous phase transition, the minima of the individual EC-FORCs trace the equilibrium curve, even at very high scan rates. Since obtaining experimental data for the EC-FORC method would require only a simple reprogramming of the potentiostat used in conventional cyclic-voltammetry experiments, we believe that this method has significant potential for ea...

  13. Belle monte-carlo production on the Amazon EC2 cloud

    International Nuclear Information System (INIS)

    The Belle II experiment which aims to increase the Luminosity of the KEKB collider by a factor of 50 will search for physics beyond the Standard Model through precision measurements and the investigation of rare processes in Flavour physics. The expected data rate is comparable to a current era LHC experiment with commensurate computing needs. Incorporating commercial cloud computing, such as that provided by the Amazon Elastic Compute Cloud (EC2) into the Belle II computing model may provide a lower Total Cost of Ownership for the Belle II computing solution. To investigate this possibility, we have created a system to conduct the complete Belle Monte Carlo simulation chain on EC2 to benchmark the cost and performance of the service. This paper will describe how this was achieved in addition to the drawbacks and costs of large-scale Monte Carlo production on EC2.

  14. 32 CFR 505.6 - Amendment of records.

    Science.gov (United States)

    2010-07-01

    ... PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM § 505.6 Amendment of records. (a) Amended records. (1... Center. (7) Inspector General investigative files and action request/complaint files (records in...

  15. AFSC/REFM: Amendment 80 Economic Data Report Dataset

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Annual series of economic data collected for years 2008 and forward for the Amendment 80 Economic Data Report (EDR). Reporting is required of holders of Amendment...

  16. 29 CFR 2200.106 - Amendment to rules.

    Science.gov (United States)

    2010-07-01

    ..., amend or revoke any of the rules contained herein. The Commission invites suggestions from interested parties to amend or revoke rules of procedure. Such suggestions should be addressed to the...

  17. 45 CFR 605.0 - Adoption of HHS regulations.

    Science.gov (United States)

    2010-10-01

    ... Provisions § 605.0 Adoption of HHS regulations. The regulations of the Department of Health and Human Services on Nondiscrimination on the Basis of Handicap, 45 CFR part 84, including any amendments thereto... 45 Public Welfare 3 2010-10-01 2010-10-01 false Adoption of HHS regulations. 605.0 Section...

  18. 33 CFR 209.300 - Flood control regulations.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Flood control regulations. 209..., DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.300 Flood control regulations. (a) Regulations for the... authority contained in Section 3 of the Flood Control Act of June 22, 1936, as amended and supplemented,...

  19. 76 FR 60357 - Golden Nematode; Removal of Regulated Areas

    Science.gov (United States)

    2011-09-29

    ... Animal and Plant Health Inspection Service 7 CFR Part 301 Golden Nematode; Removal of Regulated Areas.... SUMMARY: We are amending the golden nematode regulations by removing the townships of Elba and Byron in... two townships are free of golden nematode, and we have determined that regulation of these areas is...

  20. 75 FR 26165 - Regulation of Fuels and Fuel Additives: Alternative Affirmative Defense Requirements for Ultra...

    Science.gov (United States)

    2010-05-11

    ... amendments in the ``Rules and Regulations'' section of this Federal Register because we view this as a non... final rule and is published in the ``Rules and Regulations'' section of this Federal Register. II. Does... diesel sulfur regulations and gasoline benzene regulations in the ``Rules and Regulations'' section...