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Sample records for alveolares atroficos analisis

  1. Analisi matematica

    CERN Document Server

    Canuto, Claudio

    2014-01-01

    Il presente testo intende essere di supporto ad un secondo insegnamento di Analisi Matematica in quei corsi di studio (quali ad esempio Ingegneria, Informatica, Fisica) in cui lo strumento matematico parte significativa della formazione dell'allievo. I concetti e i metodi fondamentali del calcolo differenziale ed integrale in più variabili, le serie di funzioni e le equazioni differenziali ordinarie sono presentati con l'obiettivo primario di addestrare lo studente ad un loro uso operativo, ma critico. L'impostazione didattica dell'opera ricalca quella usata nel testo parallelo di Analisi Matematica I. La modalità di presentazione degli argomenti ne permette un uso flessibile e modulare. Lo stile adottato privilegia la chiarezza e la linearità dell'esposizione. Il testo organizzato su due livelli di lettura. Uno, più essenziale, permette allo studente di cogliere i concetti indispensabili della materia, di familiarizzarsi con le relative tecniche di calcolo e di trovare le giustificazioni dei principali r...

  2. Analisis Statistika dengan SPSS

    OpenAIRE

    Mustari, Kahar

    2012-01-01

    Buku ini membahas tentang berbagai model analisis statistika yang dapat digunakan dalam berbagai bidang penelitian. Pembahasan buku ini dilengkapi pula dengan penerapan analisis statistika yang menggunakan program SPSS versi 20 sehingga memudahkan pembaca untuk menerapkannya. Oleh karena itu, buku ini penting dibaca oleh mahasiswa atau peneliti yang melakukan pengolahan data penelitian.

  3. Pulmonary alveolar proteinosis

    Science.gov (United States)

    Alveolar proteinosis; Pulmonary alveolar phospholipoproteinosis ... In some cases, the cause of pulmonary alveolar proteinosis is unknown. In others, it occurs with lung infection or an immune problem. It also can occur with cancers of the blood system, ...

  4. Pulmonary alveolar proteinosis

    OpenAIRE

    Crestani, B; Epaud, R.; Aubier, M.; M-C. Dombret; Taille, C.; M-P. Debray; Danel, C.; R. Borie

    2011-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterised by alveolar accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte macrophage-colony stimulating factor (GM-CSF) receptor genes, it may be secondary to toxic inhalation or haematological disorders, or it may be auto-immune, with anti-GM-CSF antibodies blocking activation of alveolar macrophages. Auto-immune alveolar proteinosis is the most frequent form of PAP, representing 9...

  5. Pulmonary alveolar proteinosis

    OpenAIRE

    Patel, Sandeep M; Sekiguchi, Hiroshi; Jordan P Reynolds; Krowka, Michael J.

    2012-01-01

    Pulmonary alveolar proteinosis (PAP) is a disease of alveolar accumulation of phospholipoproteinaceous material that results in gas exchange impairment leading to dyspnea and alveolar infiltrates. There are three forms of PAP: congenital, acquired and idiopathic; of which the latter two are predominant in the adult population. Previous case studies have found that the acquired form can be secondary to various autoimmune, infectious, malignant and environmental etiologies. Recent advances in t...

  6. Pulmonary Alveolar Proteinosis

    OpenAIRE

    Patel, Sandeep M; Hiroshi Sekiguchi; Jordan P Reynolds; Krowka, Michael J.

    2012-01-01

    Pulmonary alveolar proteinosis (PAP) is a disease of alveolar accumulation of phospholipoproteinaceous material that results in gas exchange impairment leading to dyspnea and alveolar infiltrates. There are three forms of PAP: congenital, acquired and idiopathic; of which the latter two are predominant in the adult population. Previous case studies have found that the acquired form can be secondary to various autoimmune, infectious, malignant and environmental etiologies. Recent advances in t...

  7. Primary pulmonary alveolar proteinosis

    OpenAIRE

    Šarac Sanja; Milić Rade; Zolotarevski Lidija; Aćimović Slobodan; Tomić Ilija; Plavec Goran

    2012-01-01

    Introduction. Pulmonary alveolar proteinosis is an uncommon disease characterized by the accumulation of surfactant proteins and phospholipids within the alveolar spaces. Acquired disease can be idiopathic (primary) and secondary. The prevalence of acquired pulmonary alveolar proteinosis is about 0.37 per 100,000 persons. Common symptoms are dyspnea and cough. Chest X-ray shows bilateral perihilar infiltrates. Open-lung biopsy is the gold standard for the diagnosis. Treatment includes w...

  8. Extensive pulmonary alveolar microlithiasis

    OpenAIRE

    Rittayamai, Nuttapol; Muangman, Nisa; Ruangchira-Urai, Ruchira

    2013-01-01

    Pulmonary alveolar microlithiasis is a rare pulmonary disorder that is caused by abnormal sodium-dependent phosphate co-transporter from the mutation of SLC34A2 gene, leading to accumulation of microliths in the alveoli. We report the extensive pulmonary alveolar microlithiasis in an elderly woman who presented with progressive dyspnea for 2 months. Chest radiograph revealed diffuse pulmonary calcification. Tissue histopathology from open lung biopsy demonstrated widespread intra-alveolar lam...

  9. Pulmonary alveolar microlithiasis

    OpenAIRE

    Gayathri Devi, H.J.; K N Mohan Rao; Prathima, K. M.; Das, Jayanth K.

    2011-01-01

    Pulmonary alveolar microlithiasis is a rare disease of unknown cause. We report a case in a young boy who presented with history of failure to thrive and chest X-ray finding suggestive of miliary mottling. Open lung biopsy revealed pulmonary alveolar microlithiasis.

  10. Congenital Pulmonary Alveolar Proteinosis

    OpenAIRE

    Saber Hammami; Khaled Harrathi; Khaled Lajmi; Samir Hadded; Chebil Ben Meriem; Mohamed Néji Guédiche

    2013-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals. Two clinically different pediatric types have been defined as congenital PAP which is fatal and a late-onset PAP which is similar to the adult form and less severe. The clinical course of PAP is variable, ranging from spontaneous remission to respiratory failure. Whole-lung lavage is the curr...

  11. Pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    B. Crestani

    2011-06-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a rare pulmonary disease characterised by alveolar accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte macrophage-colony stimulating factor (GM-CSF receptor genes, it may be secondary to toxic inhalation or haematological disorders, or it may be auto-immune, with anti-GM-CSF antibodies blocking activation of alveolar macrophages. Auto-immune alveolar proteinosis is the most frequent form of PAP, representing 90% of cases. Although not specific, high-resolution computed tomography shows a characteristic “crazy paving” pattern. In most cases, bronchoalveolar lavage findings establish the diagnosis. Whole lung lavage is the most effective therapy, especially for auto-immune disease. Novel therapies targeting alveolar macrophages (recombinant GM-CSF therapy or anti-GM-CSF antibodies (rituximab and plasmapheresis are being investigated. Our knowledge of the pathophysiology of PAP has improved in the past 20 yrs, but therapy for PAP still needs improvement.

  12. Pulmonary Alveolar Proteinosis

    Directory of Open Access Journals (Sweden)

    Sandeep M Patel

    2012-01-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a disease of alveolar accumulation of phospholipoproteinaceous material that results in gas exchange impairment leading to dyspnea and alveolar infiltrates. There are three forms of PAP: congenital, acquired and idiopathic; of which the latter two are predominant in the adult population. Previous case studies have found that the acquired form can be secondary to various autoimmune, infectious, malignant and environmental etiologies. Recent advances in the understanding of the pathophysiology of PAP demonstrate that the idiopathic form is due to antigranulocyte macrophage-colony stimulating factor antibodies. Therapeutic targets that replace granulocyte macrophage colony stimulating factor or remove these antibodies are being actively developed. The current standard of care is to perform whole lung lavage on these patients to clear the alveolar space to help improve respiratory physiology. A case of PAP is reported, followed by a literature review on the diagnosis and management of this rare condition with the aim of increasing awareness among physicians when treating patients who present with alveolar infiltrates.

  13. Diffuse alveolar hemorrhages

    International Nuclear Information System (INIS)

    The Diffuse Alveolar Hemorrhage (DAH) it is a clinical syndrome that generally manifests with hemoptysis, anemia and infiltrated in the thorax x-ray. From the anatomical point of view, the DAH is defined as the presence of blood in the distal alveolar spaces without it can identify any endobronchial abnormality. The radiological presentation of the DAH is characterized by the presence of having infiltrated of alveolar occupation in the Rx of thorax of prevalence perihiliar and bilateral that goes converging to configure an image of complete consolidation of the air space, the apexes and the periphery of the lungs are generally respected. These infiltrated are solved in one to two weeks, but with the repeated episodes of having bled it can develop interstitial fibrosis

  14. Congenital Pulmonary Alveolar Proteinosis

    Directory of Open Access Journals (Sweden)

    Saber Hammami

    2013-01-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals. Two clinically different pediatric types have been defined as congenital PAP which is fatal and a late-onset PAP which is similar to the adult form and less severe. The clinical course of PAP is variable, ranging from spontaneous remission to respiratory failure. Whole-lung lavage is the current standard treatment for PAP patients. We report a new congenital case of PAP.

  15. Primary pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    Šarac Sanja

    2012-01-01

    Full Text Available Introduction. Pulmonary alveolar proteinosis is an uncommon disease characterized by the accumulation of surfactant proteins and phospholipids within the alveolar spaces. Acquired disease can be idiopathic (primary and secondary. The prevalence of acquired pulmonary alveolar proteinosis is about 0.37 per 100,000 persons. Common symptoms are dyspnea and cough. Chest X-ray shows bilateral perihilar infiltrates. Open-lung biopsy is the gold standard for the diagnosis. Treatment includes whole-lung lavage, application of granulocyte-macrophage colonystimulating factor and lung transplantation. Case report. We reported a 51 year-old man with primary form of the disease. It was the second case of this extremely rare disease in the past 30 years in our clinic. The symptoms were longlasting dry cough, fever and physical deterioration. Chest Xray revealed bilateral pulmonary infiltrates; computed tomography showed patchy ground-glass opacification with interlobular thickening. The diagnosis was established by open lung biopsy. Additional tests were performed to exclude secondary form of the disease. Conclusion. We presented a rare clinical entity with typical clinical features and clinical and radiological course of the disease, in order to improve differential diagnostic approach to patients with bilateral lung infiltrations. In patients with pulmonary alveolar proteinosis timely diagnosis and adequate treatment can improve a prognosis.

  16. Pulmonary alveolar proteinosis

    OpenAIRE

    Chan, Adrian Kwok Wai; Takano, Angela; Hsu, Ann Ling; Low, Su Ying

    2014-01-01

    We report a 68-year-old female who presented with chronic cough and progressive dyspnoea. Computed tomography of the thorax and subsequent bronchoscopy confirmed the diagnosis of pulmonary alveolar proteinosis (PAP), which was treated with whole lung lavage. This case is reported in view of the low incidence of PAP.

  17. ANALISIS LITERASI EKONOMI

    Directory of Open Access Journals (Sweden)

    Peter Garlans Sina

    2012-10-01

    Full Text Available Abstract: Analysis of Economic Literacy. The aim of this research is as an effort to increase economic literacy for individuals and households who want to achieve prosperity. Therefore, the obligation of improving the economic literacy needs to be done in a well-planned manner and come from the strong intention to learn in order to improve the economic literacy. It could have an effect on the assets accumulation, a better debt management, as a protection, as well as to increase savings and managing spending intelligently.   Keyword: economic literacy, asset, debt, protection, saving, spending   Abstrak: Analisis Literasi Ekonomi. Tulisan ini bertujuan sebagai upaya meningkatkan literasi ekonomi bagi individu maupun rumah tangga yang menginginkan mencapai kesejahteraan. Oleh karena itu, kewajiban meningkatkan literasi ekonomi perlu dilakukan secara terencana dan diawali dari niat untuk belajar meningkatkan literasi ekonomi karena dapat berefek pada akumulasi aset, pengelolaan utang yang tepat, proteksi, meningkatkan tabungan dan cerdas mengelola pengeluaran.   Kata kunci: literasi ekonomi, aset, utang, proteksi, menabung, pengeluaran

  18. Pulmonary alveolar proteinosis

    International Nuclear Information System (INIS)

    Since the original description of pulmonary alveolar proteinosis (PAP) as bilaterally symmetric, confluent, perihilar infiltrates, no large series evaluating the relative frequency of radiographic findings has been published. The authors reviewed 53 histologically proved cases and found a predominantly confluent pattern in 77.4%; of these, 61% had a nodular component. A predominantly nodular pattern was seen in 22.6% often with some coalescence or reticular shadows. Distribution was perhilar 56.6%, diffuse in 26.4%, basilar in 26.4%, and asymmetric in 35.8%. The classic pattern was seen in 18.9%. The authors conclude that the spectrum of patterns in pulmonary alveolar proteinosis is wider than generally appreciated

  19. The alveolar macrophage.

    OpenAIRE

    Bowden, D. H.

    1984-01-01

    The pulmonary macrophagic system is critical to the defense of the lung, keeping the alveoli clean and sterile and responding on demand with an adaptive outpouring of new cells into the air sacs. Under basal conditions alveolar macrophages, in common with other mononuclear phagocytes, are derived from the bone marrow. A population of macrophage precursors within the pulmonary interstitium provides a reserve pool capable of proliferation and delivery of phagocytes in response to unusually heav...

  20. Alveolar Development and Disease

    OpenAIRE

    Jeffrey A Whitsett; Weaver, Timothy E.

    2015-01-01

    Gas exchange after birth is entirely dependent on the remarkable architecture of the alveolus, its formation and function being mediated by the interactions of numerous cell types whose precise positions and activities are controlled by a diversity of signaling and transcriptional networks. In the later stages of gestation, alveolar epithelial cells lining the peripheral lung saccules produce increasing amounts of surfactant lipids and proteins that are secreted into the airspaces at birth. T...

  1. Pulmonary alveolar microlithiasis

    International Nuclear Information System (INIS)

    Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the diffuse and bilateral presence of calcium phosphate microlite in the alveolar spaces. The progression of this potentially lethal disease is show and most of the patients remain asymptomatic during years or decades, resulting in a show deterioration of the pulmonary function. The typical finding of the sand storm in the chest X-ray is characteristic of this entity. Mutations in the SLC34A2 gene that does the coding for the type II co-transporter of sodium phosphate were identified as responsible for this disease. Of the almost 600 cases, only 6 have been reported in Colombia. We are presenting a case of pulmonary alveolar microlite in a 27 year old man, with progressive respiratory distress whose diagnosis was made by the X-ray findings and confirmed by trans bronchial biopsy. In the 2 years follow-up, shows evolution towards deterioration of his respiratory function making him a candidate for lung transplantation.

  2. Alveolar development and disease.

    Science.gov (United States)

    Whitsett, Jeffrey A; Weaver, Timothy E

    2015-07-01

    Gas exchange after birth is entirely dependent on the remarkable architecture of the alveolus, its formation and function being mediated by the interactions of numerous cell types whose precise positions and activities are controlled by a diversity of signaling and transcriptional networks. In the later stages of gestation, alveolar epithelial cells lining the peripheral lung saccules produce increasing amounts of surfactant lipids and proteins that are secreted into the airspaces at birth. The lack of lung maturation and the associated lack of pulmonary surfactant in preterm infants causes respiratory distress syndrome, a common cause of morbidity and mortality associated with premature birth. At the time of birth, surfactant homeostasis begins to be established by balanced processes involved in surfactant production, storage, secretion, recycling, and catabolism. Insights from physiology and engineering made in the 20th century enabled survival of newborn infants requiring mechanical ventilation for the first time. Thereafter, advances in biochemistry, biophysics, and molecular biology led to an understanding of the pulmonary surfactant system that made possible exogenous surfactant replacement for the treatment of preterm infants. Identification of surfactant proteins, cloning of the genes encoding them, and elucidation of their roles in the regulation of surfactant synthesis, structure, and function have provided increasing understanding of alveolar homeostasis in health and disease. This Perspective seeks to consider developmental aspects of the pulmonary surfactant system and its importance in the pathogenesis of acute and chronic lung diseases related to alveolar homeostasis. PMID:25932959

  3. Alveolar development and disease.

    Science.gov (United States)

    Whitsett, Jeffrey A; Weaver, Timothy E

    2015-07-01

    Gas exchange after birth is entirely dependent on the remarkable architecture of the alveolus, its formation and function being mediated by the interactions of numerous cell types whose precise positions and activities are controlled by a diversity of signaling and transcriptional networks. In the later stages of gestation, alveolar epithelial cells lining the peripheral lung saccules produce increasing amounts of surfactant lipids and proteins that are secreted into the airspaces at birth. The lack of lung maturation and the associated lack of pulmonary surfactant in preterm infants causes respiratory distress syndrome, a common cause of morbidity and mortality associated with premature birth. At the time of birth, surfactant homeostasis begins to be established by balanced processes involved in surfactant production, storage, secretion, recycling, and catabolism. Insights from physiology and engineering made in the 20th century enabled survival of newborn infants requiring mechanical ventilation for the first time. Thereafter, advances in biochemistry, biophysics, and molecular biology led to an understanding of the pulmonary surfactant system that made possible exogenous surfactant replacement for the treatment of preterm infants. Identification of surfactant proteins, cloning of the genes encoding them, and elucidation of their roles in the regulation of surfactant synthesis, structure, and function have provided increasing understanding of alveolar homeostasis in health and disease. This Perspective seeks to consider developmental aspects of the pulmonary surfactant system and its importance in the pathogenesis of acute and chronic lung diseases related to alveolar homeostasis.

  4. Theoretical basis of alveolar sampling.

    OpenAIRE

    Kelman, G R

    1982-01-01

    The conditions under which the partial pressure of a solvent in the alveolar gas is likely to provide a valid index of its partial pressure in the mixed venous blood, and thus of whole-body exposure, is explored on a theoretical basis. Under steady-state conditions, providing the solvent's blood/gas partition coefficient exceeds 10, its mixed venous and alveolar pressures will agree within 10% and become virtually identical during the prolonged expiration necessary to obtain an alveolar sampl...

  5. ANALISIS PENILAIAN PRESTASI KERJA PEGAWAI

    Directory of Open Access Journals (Sweden)

    Puspita Rokhmawati

    2013-03-01

    Full Text Available Tujuan analisis ini untuk mengetahui sistem, evaluasi dan perubahan penilaian prestasi kerja pegawai UPT Balai Konservasi Tumbuhan Kebun Raya Cibodas -LIPI. Pengambilan sampel dalam penelitian ini dilakukan secara acak dengan metode yang digunakan terdiri dari beberapa bagian, yaitu studi pustaka, studi lapangan dan metode analisis. Metode yang digunakan adalah Metode Analisis SWOT. Hasil analisis menunjukkan banyak kelemahan yang muncul daripada kekuatan yang dimiliki. Peluang dan ancaman yang ada pun tidak memotivasi dalam mengimplementasi ke sistem penilaian prestasi kerja. Oleh karena itu perlu upaya mengevaluasi dan mengubah sistem penilaian prestasi kerja pegawai. Pemberian umpan balik akan mendorong kearah kemajuan dan kemungkinan meningkatkan kualitas kerja pegawai. Maka penilaian harus dibuat seobjektif dan seteliti mungkin berdasarkan data yang tersedia.The purpose of this study is  to determine the system, the  evaluation and the assessment of employees’ job performance in UPT Botanical Gardens Plant Conservation Center Cibodas - LIPI. UPT Botanical Gardens Plant Conservation Center Cibodas - LIPI has not carry out  an optimal job performance assessment. There are indications that the condition relate to the presence of subjectivity in the assessment so depth analysis is needed to find out the solution. Sampling technique uses random sampling. SWOT analysis is used to analyze the data along with study of literature and field study. The result shows that more weaknesses reveale in job performance assessment system than strengths.Opportunities and treats are ignored in implementing the job performance assessment system. Evaluation and modification are needed to improve employees’ job quality.

  6. CT in alveolar proteinosis

    International Nuclear Information System (INIS)

    Nine patients with pulmonary alveolar proteinosis (PAP) were scanned with CT. Results were not specific for PAP but may be help0ful in the differential diagnosis is visualization of pulmonary vessels is maintained and air bronchograms are scarce in diseased areas. CT is better than conventional radiography in identifying infectious complications and evaluating disease extent and may help in deciding whether or not therapeutic lavage is indicated. CT has also identified an interstitial component of PAP that correlates histologically with an inflammatory cell infiltrate. The cellular infiltrate may play a role in the development of the interstitial fibrosis seen in some cases of PAP

  7. Genetics Home Reference: pulmonary alveolar microlithiasis

    Science.gov (United States)

    ... Genetics Home Health Conditions pulmonary alveolar microlithiasis pulmonary alveolar microlithiasis Enable Javascript to view the expand/collapse boxes. Print All Open All Close All Description ...

  8. Pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    Hadice Selimoğlu Şen

    2011-06-01

    Full Text Available Pulmonary alveolar proteinosis is a rare disease characterized by the accumulation of lipoproteinosis material within the alveoli. A 36 age male patient applied to our hospital with dyspnea that began 5 months ago. Bilateral diffuse infiltration on postero-anterior chest graphy was seen. Arterial blood gas measurements (ABG was: pH:7.44, pCO2: 36 mmHg, pO2: 49 mmHg, SaO2: 85%, HCO3: 24 mmol/L. High resolution computed tomography (HRCT reported as bilateral diffuse ground glass areas and interlobuler septal thickening on this areas. Asido resistant bacillus was negative in sputum at three times and was also negative in post bronchoscopic sputum and bronchoalveoler lavage material. Wedge resection was made by video-assisted thoracoscopic surgery. Histopathology report of biopsy material revealed “Pulmonary alveolar proteinosis (PAP”. Massive lung lavage under general anesthesia was planned for patient. Clinical improvement was seen in patient beginning from admission and ABG measurements entered the recovery trend in follow-up. Partial pressure of oxygen was increased to 65 mmHg and patient was followed without lung lavage. Control chest radiography and HRCT showed significant radiological improvement. After three months, radiological lesions had completely regressed at control HRCT. As a result, in patients with symptoms and radiologically bilateral diffuse infiltration physicians should consider PAP as a rare disease in the differential diagnosis.

  9. Analisi SWOT Terhadap Manajemen Rumah Sakit

    OpenAIRE

    Rahmati MR

    2008-01-01

    SWOT adalah singkatan dari strengths dan weaknesses serta opportunities dan threats. Analisis SWOT merupakan suatu kajian terhadap kekuatan dan kelemahan internal sebuah organisasi serta kesempatan dan ancaman lingkungan eksternalnya. Teknik analisis SWOT yang digunakan adalah mathematics of SWOT yaitu dengan menggunakan rumus (S-W) + (0—T), jika hasil yang diperoleh plus maka strateginya adalah menguatkan S dan O, jika equal maka strateginya adalah mengurangi W dan T9 dan jika minus maka ...

  10. PPARs in Alveolar Macrophage Biology

    Directory of Open Access Journals (Sweden)

    Monica R. Smith

    2007-01-01

    Full Text Available PPARs, most notably PPAR-γ, play a crucial role in regulating the activation of alveolar macrophages, which in turn occupy a pivotal place in the immune response to pathogens and particulates drawn in with inspired air. In this review, we describe the dual role of the alveolar macrophage as both a first-line defender through its phagocytotic activity and a regulator of the immune response. Depending on its state of activation, the alveolar macrophage may either enhance or suppress different aspects of immune function in the lung. We then review the role of PPAR-γ and its ligands in deactivating alveolar macrophages—thus limiting the inflammatory response that, if unchecked, could threaten the essential respiratory function of the alveolus—while upregulating the cell's phagocytotic activity. Finally, we examine the role that inadequate or inappropriate PPAR-γ responses play in specific lung diseases.

  11. Abses Alveolar Akut Pada Anak

    OpenAIRE

    Delfitri, Meri

    2008-01-01

    Abses alveolar akut adalah suatu kumpulan nanah yang terlokalisasi dalam tulang alveolar sekitar apeks gigi setelah kematian pulpa yang merupakan kelanjutan proses infeksi yang mulai di pulpa dan berkembang ke jaringan periapikal. Perluasan infeksi dari pulpa non vital dapat melalui foramen apikal menuju jaringan periapikal yang mengakibatkan inflamasi akut, bila disertai dengan meningkatnya virulensi bakteri streptokokus alfa, disertai staffilokokus dan sejumlah anaerob lainnya serta r...

  12. Micronuclei in human alveolar macrophages.

    Science.gov (United States)

    D'Agostini, F; Bonatti, S; Oddera, S; De Flora, S

    1992-01-01

    Occurrence of micronuclei was monitored in pulmonary alveolar macrophages collected from 31 individuals undergoing diagnostic bronchoalveolar lavage. The overall frequency of micronucleated cells was 3.88 +/- 1.84/1000, without any significant difference attributable to sex, age, pathology, occupation, or smoking habits. The lack of influence of cigarette smoke on this clastogenicity index presumably reflects the very low rate of mitoses of macrophages in the alveolar lumen. PMID:1579732

  13. Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

    Science.gov (United States)

    Westphalen, Kristin; Gusarova, Galina A.; Islam, Mohammad N.; Subramanian, Manikandan; Cohen, Taylor S.; Prince, Alice S.; Bhattacharya, Jahar

    2014-02-01

    The tissue-resident macrophages of barrier organs constitute the first line of defence against pathogens at the systemic interface with the ambient environment. In the lung, resident alveolar macrophages (AMs) provide a sentinel function against inhaled pathogens. Bacterial constituents ligate Toll-like receptors (TLRs) on AMs, causing AMs to secrete proinflammatory cytokines that activate alveolar epithelial receptors, leading to recruitment of neutrophils that engulf pathogens. Because the AM-induced response could itself cause tissue injury, it is unclear how AMs modulate the response to prevent injury. Here, using real-time alveolar imaging in situ, we show that a subset of AMs attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with the epithelium. During lipopolysaccharide-induced inflammation, the AMs remained sessile and attached to the alveoli, and they established intercommunication through synchronized Ca2+ waves, using the epithelium as the conducting pathway. The intercommunication was immunosuppressive, involving Ca2+-dependent activation of Akt, because AM-specific knockout of Cx43 enhanced alveolar neutrophil recruitment and secretion of proinflammatory cytokines in the bronchoalveolar lavage. A picture emerges of a novel immunomodulatory process in which a subset of alveolus-attached AMs intercommunicates immunosuppressive signals to reduce endotoxin-induced lung inflammation.

  14. Displasia alveolar congénita Congenital alveolar dysplasia

    OpenAIRE

    D.P. Sánchez Hernández; M.M. Suárez Galvis; M.T. García Vélez; A. Uribe Molina

    2012-01-01

    La displasia alveolar congénita es una patología congénita poco frecuente caracterizada por disminución de las unidades alveolares y anormalidades del desarrollo de la vasculatura pulmonar. Esta entidad produce hipertensión pulmonar severa e hipoxemia persistente con una evolución mortal en la mayoría de los casos. Afecta generalmente a recién nacidos a término, con un test de Apgar normal, que posteriormente desarrollan dificultad respiratoria, habitualmente en el primer día de vida. La enfe...

  15. Pulmonary alveolar proteinosis in a cat

    OpenAIRE

    Szatmári, Viktor; Teske, Erik; Peter G. J. Nikkels; Griese, Matthias; de Jong, Pim A.; Grinwis, Guy; Theegarten, Dirk; Veraa, Stefanie; van Steenbeek, Frank G.; Drent, Marjolein; Bonella, Francesco

    2015-01-01

    BACKGROUND: Pulmonary alveolar proteinosis is an extremely rare lung disease in animals and humans. It is characterized by the deposition of a large amount of phospholipoproteinaceous material in the alveoli. There are several possible etiologies, both congenital and acquired. Alveolar macrophages play an important role in the clearance of surfactant. This is the first report of pulmonary alveolar proteinosis in the feline species. CASE PRESENTATION: Pulmonary alveolar proteinosis was diagnos...

  16. Pulmonary alveolar microlithiasis with calcified pleural plaques

    Directory of Open Access Journals (Sweden)

    Malhotra Balbir

    2010-01-01

    Full Text Available Pulmonary alveolar microlithiasis (PAM is a rare disease. Herein we report a case of pulmonary alveolar microlithiasis who was suspected to have the disease on chest X-ray and was confirmed on high resolution CT and transbronchial lung biopsy. These investigations showed characteristic features of pulmonary alveolar microlithiasis with diffuse interstitial pulmonary fibrosis.

  17. Pulmonary alveolar microlithiasis with calcified pleural plaques

    OpenAIRE

    Malhotra Balbir; Sabharwal Raghu; Singh Mandeep; Singh Amarjeet

    2010-01-01

    Pulmonary alveolar microlithiasis (PAM) is a rare disease. Herein we report a case of pulmonary alveolar microlithiasis who was suspected to have the disease on chest X-ray and was confirmed on high resolution CT and transbronchial lung biopsy. These investigations showed characteristic features of pulmonary alveolar microlithiasis with diffuse interstitial pulmonary fibrosis.

  18. Aplikasi Analisis DNA dalam Bidang Forensik

    Directory of Open Access Journals (Sweden)

    Elza Ibrahim Auerkari

    2015-10-01

    Full Text Available Analisis DNA dalam bidang forensik merupakan teknik yang relatif baru dan berkembang pesar sesuai dengan peningkatan kualitas dan kuantitas kriminalitas disamping dapat digunakan dalam penentuan hubungan keluarga. Permasalahannya adalah bagaimana kemampuan analisis DNA ini dalam mengidentifikasi individu pada kasus-kasus tersebut. Dari 3,3 milyar pasang basa yang membentuk genom manusia, terdapat sekitar 3 juta perbedaan di antara setiap dua individu. Untuk tujuan identifikasi DNA dalam bidang forensik, regio yang sangat penting adalah lokus polimorfik DNA termasuk regio ukuran satelit (Satelite sequence pada bagian yang tidak mengkode produk tertentu dari genom manusia. Bila frekuensi folimorfis DNA pada suatu populasi diketahui, probabilitas dari identifikasi, lokus polimorfik dengan frekuensi yang diketahui dalam suatu populasi dapat dipilih sebagai DNA maeker. Analisis DNA merupakan suatu metode yang sangat potensial yang dewasa ini telah diterima secara luas sebagai suatu cara identifikasi dalam bidang forensik, sebab hanya dibutuhkan sedikit sampel saja yang dapat diambil dari semua sel berinti di seluruh tubuh. Penggunaan analisis DNA dan bank data DNA berkembang dengan pesat serta merupakan sarana yang penting sebagai pelengkap terhadap bidang kedokteran dan kedokteran gigi forensik lainnya. Guna efisiensi identifikasi di bidang forensik dianjurkan agar metode-metode yang ada dikombinasi.

  19. PRINSIP DAN METODE ANALISIS RISIKO KESEHATAN LINGKUNGAN

    Directory of Open Access Journals (Sweden)

    Defriman Djafri

    2014-04-01

    Full Text Available Analisis risiko kesehatan lingkungan merupakan penilaian atau penaksiran risiko kesehatan yang bisa terjadi di suatu waktu pada populasi manusia berisiko. Kajian prediktif ini menghasilkan karakteristik risiko secara kuantitatif, pilihan-pilihan manajemen risiko dan strategi komunikasi untuk meminimalkan risiko tersebut. Data kualitas lingkungan yang bersifat agent specific dan site specific, karakteristik antropometri dan pola aktivitas populasi terpajan dibutuhkan untuk kajian ini.

  20. PRINSIP DAN METODE ANALISIS RISIKO KESEHATAN LINGKUNGAN

    OpenAIRE

    Defriman Djafri

    2014-01-01

    Analisis risiko kesehatan lingkungan merupakan penilaian atau penaksiran risiko kesehatan yang bisa terjadi di suatu waktu pada populasi manusia berisiko. Kajian prediktif ini menghasilkan karakteristik risiko secara kuantitatif, pilihan-pilihan manajemen risiko dan strategi komunikasi untuk meminimalkan risiko tersebut. Data kualitas lingkungan yang bersifat agent specific dan site specific, karakteristik antropometri dan pola aktivitas populasi terpajan dibutuhkan untuk kajian ini.

  1. Analisis SWOT pada Toko Lestari Rattan and Furniture Jl. Gatot Subroto No. 457 Medan

    OpenAIRE

    Desira, Sheila

    2011-01-01

    Penelitian ini bertujuan untuk menganalisis SWOT yang ada pada Toko Lestari Rattan and Furniture. Analisis SWOT merupakan penilaian lingkungan internal berupa kekuatan (strength) dan kelemahan (weakness) serta lingkungan eksternal berupa peluang (opportunity) dan ancaman (treath). Analisis SWOT akan menghasilkan strategi yang tepat bagi perusahaan. Analisis SWOT umumnya digunakan pada perusahaan besar. Penelitian ini melihat penerapan analisis SWOT pada UKM (Usaha Kecil Mene...

  2. Alveolar hypoventilation treated with medroxyprogesterone.

    OpenAIRE

    Milerad, J; Lagercrantz, H.; Löfgren, O

    1985-01-01

    Two children aged 1 and 20 months developed alveolar hypoventilation syndrome. They suffered severe apnoeic episodes and periodically required assisted ventilation. Their ventilatory response to carbon dioxide was lower than that of normal children and the transcutaneous oxygen tension during sleep was well below the normal range. Treatment with medroxyprogesterone acetate resulted in an improved response to carbon dioxide, and assisted ventilation was no longer needed. Oxygen and carbon diox...

  3. [Alveolar sarcoma. Report of a case].

    Science.gov (United States)

    Devisme, L; Mensier, E; Bisiau, S; Bloget, F; Gosselin, B

    1996-01-01

    Alveolar soft part sarcoma occurs mostly in the deep soft tissues. An unusual case of primary pulmonary alveolar soft part sarcoma is reported. A 39-year-old woman presented with thoracic pain revealing the tumor. The left lower lobe was surgically resected. The microscopic features of this tumor, including characteristic alveolar pattern and the PAS-positive crystals were typical of alveolar soft part sarcoma. Immunohistochemically, granular cytoplasmic reactivities were observed with antibodies against vimentin, myoglobin, methionine-enkephalin, S100 protein and neuron-specific-enolase. Electron microscopic study demonstrated numerous crystallized structures in the tumor cell cytoplasm. This is the third case of pulmonary alveolar soft part sarcoma, one arising from the pulmonary vein. The histogenesis of alveolar soft part sarcoma is still debated. Our case does not allow distinction between myogenic or neural origin of this tumor.

  4. Alveolar septal pulmonary amyloidosis: a case report

    International Nuclear Information System (INIS)

    Primary pulmonary amyloidosis is a rare diesase, and is classified as either tracheobronchial or parenchymal; the latter is also divided into nodular and diffuse alveolar septal forms. The alveolar septal form is extremely rare and usually produces reticular and nodular opacities. We describe a case of alveolar septal pulmonary amyloidosis manifested as multiple small nodules on chest radiograph and disseminated micronodules mainly in centrilobular and subpleural location without reticular opacities, on HRCT

  5. [Pulmonary alveolar microlithiasis: Report of one case].

    Science.gov (United States)

    Fernández F, Cristina; Salinas F, Mauricio; de Grazia K, José Andrés; Díaz P, Juan Carlos

    2014-05-01

    Pulmonary alveolar microlithiasis is an extremely rare disease characterized by intra-alveolar accumulation of calcified spherical particles (called microliths), due to a mutation of the gene encoding a membrane transport protein of the alveolar surface. Most patients are asymptomatic at diagnosis. The course of the disease is slowly progressive, with development of pulmonary fibrosis and respiratory failure. The "sandstorm" pattern is the characteristic finding of this disease. We report a 39-year-old female presenting with progressive dyspnea. A chest X ray showed ground-glass opacities and a high resolution CT scan showed numerous calcified lung micronodules. A surgical lung biopsy confirmed the diagnosis of pulmonary alveolar microlithiasis. PMID:25427025

  6. Analisis SWOT Dalam Upaya Meningkatkan Keunggulan Bersaing Pada Salon Cleopatra

    OpenAIRE

    Syafitri, Yudhi

    2010-01-01

    Tujuan penelitian adalah untuk mengetahui dan menganalisis peranan analisis SWOT dalam upaya meningkatkan keunggulan bersaing pada Salon Cleopatra. Kesimpulan yang diperoleh penulis berdasarkan hasil dari penelitian yang dilakukan dengan menggunakan analisis SWOT dan Matriks SPACE dengan strategi agresif yang dilakukan oleh Salon Cleopatra sudah cukup baik, akan tetapi Salon Cleopatra melakukan strategi berdasarkan pengalaman, insting dan keadaan pasar, bukan dilakukan berdasarkan strategi a...

  7. ANALISIS PERBANDINGAN SPAP, IAS DAN SPKN

    OpenAIRE

    Maylia Pramono Sari

    2012-01-01

    Dalam mewujudkan Good Goveronance  akan dilakukan analisis perbandingan mengenai standar pemeriksaan nasional yaitu SPAP, ISA, dan SPKN untuk menemukan standar yang lebih tepat dan lebih lengkap untuk pemeriksaan sektor publik. Persamaan SPKN dan ISS  adalah tanggungjawab manajemen dan tanggungjawab auditor sedangkan perbedaannya adalah badan yang menerbitkannya. Perbedaan yang mendasar terletak pada karakter pemeriksaan BPK. Karakter tersebut adalah keharusan pemeriksa BPK untuk merancang ...

  8. Computed tomographic imaging of pulmonary alveolar proteinosis

    International Nuclear Information System (INIS)

    Pulmonary alveolar proteinosis is a rare disease of uncertain etiology. The computed tomographic image is characterized by geographically sharply delineated alveolar infiltrates, faint, ground-glass-like parenchymal turbidity, with well bordered interstitial structures and recesses in the subpleural space. (orig.)

  9. CT quantification of pulmonary alveolar microlithiasis

    International Nuclear Information System (INIS)

    Pulmonary alveolar microlithiasis is a rare, familial disease with massive symmetrical intra-alveolar calcium deposition. Conventional CT findings and CT measurements with a dual energy technique were carried out in a 26-year-old patient suffering from this disease. The importance of the findings in the differential diagnosis and for estimating the progression and prognosis of the disease is discussed. (orig.)

  10. Pulmonary alveolar microlithiasis in children

    International Nuclear Information System (INIS)

    Two asymptomatic Turkish sibs are presented, a 4-year-old boy and his 7-year-old sister, with pulmonary alveolar microlithiasis (PAM) confirmed by transbronchial lung biopsy and bronchoalveolar lavage. Chest radiographs and high resolution CT demonstrated wide-spread intra-alveolar calcifications in both lungs. The lesions were sharply defined and less than 1 mm in diameter. CT documented a high concentration of microliths along the bronchovascular bundles, the intralobular fissue and the (sub)pleural lung parenchyma. The combination of bronchoalveolar lavage and roentgenographic appearance in high resolution CT are characteristic and pathognomonic, and can confirm the diagnosis. The more severe changes in the elder sib and the radiographic controls suggest that the pulmonary disease may be progressive in our patients. The described family of consanguineous, unaffected parents with two affected and one healthy child confirmed the autosomal recessive inheritance of PAM (McKusick 265100). In addition, the affected girl had autosomal recessive Waardenburg-anophthalmia syndrome (McKusick 206920), raising the question of whether this is a chance occurrence or possibly a contiguous gene syndrome. (orig.)

  11. Pulmonary alveolar microlithiasis in children

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, H. [Center of Diagnostic Radiology, Frankfurt Univ. (Germany); Loercher, U. [Center of Diagnostic Radiology, Frankfurt Univ. (Germany); Kitz, R. [Center of Pediatrics, Frankfurt Univ. (Germany); Zielen, S. [Center of Pediatrics, Frankfurt Univ. (Germany); Ahrens, P. [Center of Pediatrics, Frankfurt Univ. (Germany); Koenig, R. [Inst. of Human Genetics, Frankfurt Univ. (Germany)

    1996-01-01

    Two asymptomatic Turkish sibs are presented, a 4-year-old boy and his 7-year-old sister, with pulmonary alveolar microlithiasis (PAM) confirmed by transbronchial lung biopsy and bronchoalveolar lavage. Chest radiographs and high resolution CT demonstrated wide-spread intra-alveolar calcifications in both lungs. The lesions were sharply defined and less than 1 mm in diameter. CT documented a high concentration of microliths along the bronchovascular bundles, the intralobular fissue and the (sub)pleural lung parenchyma. The combination of bronchoalveolar lavage and roentgenographic appearance in high resolution CT are characteristic and pathognomonic, and can confirm the diagnosis. The more severe changes in the elder sib and the radiographic controls suggest that the pulmonary disease may be progressive in our patients. The described family of consanguineous, unaffected parents with two affected and one healthy child confirmed the autosomal recessive inheritance of PAM (McKusick 265100). In addition, the affected girl had autosomal recessive Waardenburg-anophthalmia syndrome (McKusick 206920), raising the question of whether this is a chance occurrence or possibly a contiguous gene syndrome. (orig.)

  12. A case of pulmonary alveolar microlithiasis

    International Nuclear Information System (INIS)

    A case of pulmonary alveolar microlithiasis is reported. A 33-year-old male visited our clinic because of cough and sore throat. The chest X-ray showed granular micronodulation diffusely disseminated throughout the lung fields. On the eighth day since admission, cough and sore throat disappeared. Pulmonary alveolar microlithiasis was confirmed by transbronchial lung biopsy. Bronchoalveolar lavage (BAL) was performed, and the differential cell count of the BAL fluid showed 74.3 % eosinophilia. Furthermore, 67Ga-citrate scintigraphy revealed diffuse uptake throughout the lung fields. Whether these findings are common in pulmonary alveolar microlithiasis or not is considered to be an unanswered problem. (author)

  13. Integrity of the alveolar-capillary barrier and alveolar surfactant system in smokers.

    OpenAIRE

    Schmekel, B; Bos, J.A.; A. R. Khan; Wohlfart, B; Lachmann, B.; Wollmer, P.

    1992-01-01

    BACKGROUND: The permeability of the alveolar-capillary barrier to technetium-99m labelled diethylenetriamine pentaacetate (99mTc DTPA) is known to be greatly increased in smokers, but the underlying mechanism is poorly understood. Abnormal permeability of the alveolar epithelium as well as impaired surfactant function has been suggested. The purpose of this study was to examine transudation of urea and albumin into the alveoli and alveolar surfactant function in smokers and non-smokers and to...

  14. Alveolar hydatid cyst: A case report

    Directory of Open Access Journals (Sweden)

    Behiye Zarif-Zakerian

    2010-06-01

    Full Text Available Alveolar hydatid cyst is a parasitic disease due to invasion of the Echinococcus multilocularis larva into the different tissues. The main host of this tape worms is Canidae family, especially foxes and jackals. Human beings are usually infected through eating contaminated vegetables and water with parasite eggs. In this article, one case of alveolar hydatid cyst has been reported in a 35 year-old woman

  15. Rare Lung Diseases II: Pulmonary Alveolar Proteinosis

    OpenAIRE

    Juvet, Stephen C; David Hwang; Waddell, Thomas K; Downey, Gregory P.

    2008-01-01

    The present article is the second in a series on rare lung diseases. It focuses on pulmonary alveolar proteinosis (PAP), a disorder in which lipoproteinaceous material accumulates in the alveolar space. PAP was first described in 1958, and for many years the nature of the material accumulating in the lungs was unknown. Major insights into PAP have been made in the past decade, and these have led to the notion that PAP is an autoimmume disorder in which autoantibodies interfere with signalling...

  16. The Molecular Basis of Pulmonary Alveolar Proteinosis

    OpenAIRE

    Carey, Brenna; Trapnell, Bruce C.

    2010-01-01

    Pulmonary alveolar proteinosis (PAP) comprises a heterogenous group of diseases characterized by abnormal surfactant accumulation resulting in respiratory insufficiency, and defects in alveolar macrophage- and neutrophil-mediated host defense. Basic, clinical and translational research over the past two decades have raised PAP from obscurity, identifying the molecular pathogenesis in over 90% of cases as a spectrum of diseases involving the disruption of GM-CSF signaling. Autoimmune PAP repre...

  17. Pulmonary alveolar proteinosis: diagnostic and therapeutic challenges

    OpenAIRE

    Campo Ilaria; Kadija Zamir; Mariani Francesca; Paracchini Elena; Rodi Giuseppe; Mojoli Francesco; Braschi Antonio; Luisetti Maurizio

    2012-01-01

    Abstract Pulmonary Alveolar Proteinosis (PAP) is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals and in distinct clinical forms: autoimmune (previously referred to as the idiopathic form, represents the vast majority of PAP cases, and is associated with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) auto-antibodies; GMAbs), secondary (is a consequence of underlying dis...

  18. A case report of pulmonary alveolar proteinosis

    OpenAIRE

    McDermott, Helen; Aitchison, Frances; Nathani, Nazim; Bhatnager, Anjali

    2009-01-01

    This is a case of pulmonary alveolar proteinosis that presented in an inner city hospital in Birmingham, UK. The patient was a previously well 42-year-old man, who went on to experience unusual cerebral complications of the disease. The presentation, imaging findings and diagnostic histology findings are described. Pulmonary alveolar proteinosis is a rare but important diagnosis. Characteristic high-resolution CT findings include diffuse ground glass density with superimposed interlobular sep...

  19. Toward Therapeutic Pulmonary Alveolar Regeneration in Humans

    OpenAIRE

    Massaro, Donald; Massaro, Gloria DeCarlo

    2006-01-01

    In humans, age results in loss of pulmonary alveoli; menopause accelerates loss of diffusing capacity, an index of alveolar surface area; and disease (e.g., chronic obstructive pulmonary disease) results in loss of alveoli. Thus, an important goal for investigators is to generate knowledge that allows induction of pulmonary alveolar regeneration in humans. Our enthusiasm for this goal and our assessment of its feasibility are based on work in several laboratories over the last decade that has...

  20. Lung Transplant Recipient with Pulmonary Alveolar Proteinosis

    OpenAIRE

    Tokman, Sofya; Hahn, M. Frances; Abdelrazek, Hesham; Panchabhai, Tanmay S.; Patel, Vipul J.; Walia, Rajat; Omar, Ashraf

    2016-01-01

    Pulmonary alveolar proteinosis (PAP) is a progressive lung disease characterized by accumulated surfactant-like lipoproteinaceous material in the alveoli and distal bronchioles. This accumulation is the result of impaired clearance by alveolar macrophages. PAP has been described in 11 solid organ transplant recipients, 9 of whom were treated with mammalian target of rapamycin inhibitors. We report a case of a lung transplant recipient treated with prednisone, mycophenolate mofetil (MMF), and ...

  1. Remodeling of alveolar septa after murine pneumonectomy.

    Science.gov (United States)

    Ysasi, Alexandra B; Wagner, Willi L; Bennett, Robert D; Ackermann, Maximilian; Valenzuela, Cristian D; Belle, Janeil; Tsuda, Akira; Konerding, Moritz A; Mentzer, Steven J

    2015-06-15

    In most mammals, removing one lung (pneumonectomy) results in the compensatory growth of the remaining lung. In mice, stereological observations have demonstrated an increase in the number of mature alveoli; however, anatomic evidence of the early phases of alveolar growth has remained elusive. To identify changes in the lung microstructure associated with neoalveolarization, we used tissue histology, electron microscopy, and synchrotron imaging to examine the configuration of the alveolar duct after murine pneumonectomy. Systematic histological examination of the cardiac lobe demonstrated no change in the relative frequency of dihedral angle components (Ends, Bends, and Junctions) (P > 0.05), but a significant decrease in the length of a subset of septal ends ("E"). Septal retraction, observed in 20-30% of the alveolar ducts, was maximal on day 3 after pneumonectomy (P alveolar duct diameter ratio (Dout:Din) was significantly lower 3 days after pneumonectomy compared to all controls except for the detergent-treated lung (P surface tension within the alveolar duct, resulting in a new equilibrium at a higher total energy and lower surface area. The spatial and temporal association of these microstructural changes with postpneumonectomy lung growth suggests that these changes represent an early phase of alveolar duct remodeling. PMID:26078396

  2. Particulate concentrations in pulmonary alveolar proteinosis

    Energy Technology Data Exchange (ETDEWEB)

    McEuen, D.D.; Abraham, J.L. (Univ. of California, San Diego, La Jolla (USA))

    1978-12-01

    Quantitative birefringent particle counts per 10 high-power fields in lung tissue were correlated with age, sex, and occupational exposure in 37 cases of pulmonary alveolar proteinosis. Counts were significantly higher in pulmonary alveolar proteinosis cases in both regions of alveolar proteinosis (47 {plus minus} 11) and perivascular and peribronchiolar areas (dust retention areas) (275 {plus minus} 65) than in 13 controls (5 {plus minus} 3 and 79 {plus minus} 23, respectively). Of a total of 8619 particles, 4817 were less than 1 micron, and 3771 were 1 to 10 microns in diameter. Fifty-nine percent were round, 19% fibrous, and 22% irregular. When analyzed individually, 20 of 37 cases (78%) had alveolar particle counts significantly higher than controls, and 10 of 26 cases had dust-retention area counts greater than controls (P less than 0.050). Known or possible occupational exposure was ascertained in 13 cases. In the remaining 24 cases insufficient occupational information was available. The mean age of the pulmonary alveolar proteinosis patients was 33 {plus minus} 4 years, and of the controls, 40 {plus minus} 7 years, and there was a male-to-female ratio of approximately 3:1. We propose that many cases of pulmonary alveolar proteinosis will ultimately be shown to be associated with environmental exposures to fine dusts or fumes.

  3. Desain Dan Analisis Perhitungan Roda Pendaratan Pesawat Tanpa Awak

    OpenAIRE

    Aulia, T. Muhammad Rinaldi

    2015-01-01

    Landing gear merupakan struktur pesawat yang berfungsi menahan beban statis pesawat dan juga beban dinamis ketika pesawat melakukan pendaratan. Dalam mendesain landing gear dilakukan pemilihan jenis landing gear dan dilakukan analisis perhitungan pada tiap komponen landing gear yang meliputi pusat gravitasi, tinggi pesawat, wheel base, wheel track, dan roda. Desain dan analisis perhitungan dilakukan dengan metode studi pustaka dimana setiap desain dan perhitungan didasarkan pada literatur pu...

  4. Nasionalisme dalam Novel 5 cm. Karya Donny Dhirgantoro: Analisis Strukturalisme

    OpenAIRE

    Ichwan, Yasir

    2014-01-01

    Penelitian ini menganalisis tentang struktur yang membangun nilai nasionalisme dan bentuk nasionalisme dalam novel 5 cm. karya Donny Dhirgantoro. Adapun tujuan penelitian ini adalah untuk memahami makna nasionalisme secara lebih luas. Metode pengumpulan data yang dilakukan peneliti adalah teknik pustaka, baca, dan catat. Teknik analisis data yang dilakukan peneliti adalah menganalisis unsur-unsur pembangun novel, mengaitkan antara unsur pembangun novel, menyajikan hasil analisis, dan menyimpu...

  5. Kajian Bentuk Pengolahan dan Analisis Finansial Buah Api api (Avicennia officinalis L.) Sebagai Bahan Makanan dan Minuman di Kabupaten Deli Serdang

    OpenAIRE

    Sianturi, Gustinaria

    2013-01-01

    Penelitian ini bertujuan untuk mengidentifikasi bentuk pengolahan, tingkat kelayakan nilai finansial, dan strategi pengembangan usaha pengolahan buah api-api (Avicennia officinalis L.) di Dusun Paluh Merbau, Desa Tanjung Rejo, Kecamatan Percut Sei Tuan, Kabupaten Deli Serdang. Metode analisis yang digunakan adalah analisis deskriptif, analisis finansial, dan analisis strategi pengembangan usaha dengan menggunakan analisis SWOT. Hasil penelitian menunjukkan bahwa produk olahan buah api-...

  6. Analisis Faktor yang Mempengaruhi Indeks Prestasi Mahasiswa

    Directory of Open Access Journals (Sweden)

    Putriaji Hendikawati

    2011-12-01

    Full Text Available Penelitian ini dilaksanakan untuk mengungkap dan menganalisis faktor-faktor yangmempengaruhi perolehan indeks prestasi mahasiswa. Populasi penelitian adalahmahasiswa program studi Pendidikan Matematika FMIPA Unnes dan dipilih sampelsebanyak 3 kelas. Pengambilan sampel dilakukan dengan cara stratified cluster randomsamplingdengan sampel penelitian berjumlah 114 mahasiswa.Hasil penelitian menunjukkan bahwa Indeks Prestasi (IP mahasiswa dipengaruhioleh beberapa variabel antara lain: variabel suasana hati, membagi waktu, hubungandengan keluarga, penjelasan dosen, suasana tempat tinggal, kegiatan selain kuliah, bakat,adaptasi lingkungan, pantauan orang tua, perhatian orang tua, pergaulan, makan dan gizi,IQ dan EQ, kemampuan sosialisasi, kondisi keuangan, suasana belajar kampus, pancaindera kemampuan menangkap materi, dan olahraga. Setelahdilakukan analisis faktor danproses reduksi diperoleh5 faktor yang mempengaruhi IP mahasiswa. Lima faktor tersebutadalah Faktor Manajemen Diri, Faktor Lingkungan Sekitar, Faktor Kondisi Eksternal,Faktor Kondisi Fisik dan Faktor Olahraga.Hasil penelitian ini bermanfaat bagi mahasiswa serta para dosen khususnyapenentu kebijakan di jurusan Matematika FMIPA Unnes, untuk mengembangkan sertameningkatkan faktor-faktor yang mempengaruhi IP mahasiswa yang berhubungan dengankebijakan dalam kampus agar dapat memberikan kontribusi positif bagi perolehan IPmahasiswa. Kata kunci: analisis faktor, indeks prestasi, mahasiswa.

  7. Perawatan Ortodontik Gigi Anterior Berjejal dengan Tulang Alveolar yang Tipis

    Directory of Open Access Journals (Sweden)

    Miesje K. Purwanegara

    2015-09-01

    Full Text Available Anterior teeth movement in orthodontic treatment is limited to labiolingual direction by very thin alveolar bone. An uncontrolled anterior tooth movement to labiolingual direction can cause alveolar bone perforation at its root segment. This case report is to remind us that alveolar bone thickness limits orthodontc tooth movement. A case of crowded anterior teeth with thin alveolar bone in malocclusion I is reported. This case is treated using adgewise orthodontic appliance. Protraction of anterior teeth is anticipated due to thin alveolar bone on the anterior surface. The conclusion is although the alveolar bone surrounding the crowded anterior teeth is thin, by controlling the movement the teeth reposition is allowed.

  8. Lateralization Technique and Inferior Alveolar Nerve Transposition

    Directory of Open Access Journals (Sweden)

    Angélica Castro Pimentel

    2016-01-01

    Full Text Available Bone resorption of the posterior mandible can result in diminished bone edge and, therefore, the installation of implants in these regions becomes a challenge, especially in the presence of the mandibular canal and its contents, the inferior alveolar nerve. Several treatment alternatives are suggested: the use of short implants, guided bone regeneration, appositional bone grafting, distraction osteogenesis, inclined implants tangential to the mandibular canal, and the lateralization of the inferior alveolar nerve. The aim was to elucidate the success rate of implants in the lateralization technique and in inferior alveolar nerve transposition and to determine the most effective sensory test. We conclude that the success rate is linked to the possibility of installing implants with long bicortical anchor which favors primary stability and biomechanics.

  9. Lateralization Technique and Inferior Alveolar Nerve Transposition

    Science.gov (United States)

    Sanches, Marco Antonio; Ramalho, Gabriel Cardoso; Manzi, Marcello Roberto

    2016-01-01

    Bone resorption of the posterior mandible can result in diminished bone edge and, therefore, the installation of implants in these regions becomes a challenge, especially in the presence of the mandibular canal and its contents, the inferior alveolar nerve. Several treatment alternatives are suggested: the use of short implants, guided bone regeneration, appositional bone grafting, distraction osteogenesis, inclined implants tangential to the mandibular canal, and the lateralization of the inferior alveolar nerve. The aim was to elucidate the success rate of implants in the lateralization technique and in inferior alveolar nerve transposition and to determine the most effective sensory test. We conclude that the success rate is linked to the possibility of installing implants with long bicortical anchor which favors primary stability and biomechanics. PMID:27433360

  10. Whole lung lavage for pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    Jayaraman S

    2010-01-01

    Full Text Available A 26-year-old male presented with complaints of dry cough of six months and progressive breathlessness of three months duration. He was coughing out milky white sputum for two months and had lost 12 kg weight in two months. He had an evening rise in temperature of one month duration. Clinically, the patient was in respiratory distress and the respiratory system examination revealed bilateral velcro crackles. High resolution computed tomography chest showed bilateral diffuse reticulonodular opacities and "Crazy Paving" pattern suggestive of alveolar proteinosis. Broncho alveolar lavage showed eosinophilic granular material, which was periodic acid-Schiff positive. Open lung biopsy was done to confirm the diagnosis and the histopathologic examination revealed eosinophilic secretions with granular appearance suggestive of pulmonary alveolar proteinosis. Subsequently, patient underwent bilateral sequential whole lung lavage under general anesthesia. Patient showed marked clinical and radiological improvement after sequential whole lung lavage.

  11. Impairment of Alveolar Macrophage Transcription in Idiopathic Pulmonary Fibrosis

    OpenAIRE

    Ren, Ping; Rosas, Ivan O.; MacDonald, Sandra D.; Wu, Hai-Ping; Billings, Eric M; Gochuico, Bernadette R.

    2007-01-01

    Rationale: Alveolar macrophages are inflammatory cells that may contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF), which is characterized by excessive alveolar aggregation of cells and extracellular matrix proteins.

  12. PENENTUAN DAERAH RAWAN GIZI BERDASARKAN ANALISIS SPATIAL

    Directory of Open Access Journals (Sweden)

    Noviati Fuada

    2012-11-01

    Full Text Available Latar Belakang : Riset Kesehatan Dasar telah dilakukan di Indonesia (RISKESDAS 2007. Riset telah mengumpulkan data-data yang terdiri dari data kesehatan yang menggambarkan status gizi anak di bawah lima (antrophometri data di seluruh wilayah Indonesia. Kenyataanya masih sedikit analisis dengan menggunakan metode GIS, oleh karena itu artikel ini akan dikaji dengan metode spasial. Kajian ini diharapkan dapat memberikan informasi faktual, yang dapat mendukung kebijakan daerah. Tujuan: Mengidentifikasi daerah kabupaten/provinsi rawan status gizi anak balita, Metode: Analisa GIS denganmenggunakan metode spasial (pengelompokan data dan overlay dengan cara union. Data RISKESDAS 2007. Hasil: Wilayah tingkat tinggi potensi rawan gizi bermasalah (bersumber overlay antara peta sebaran status gizi balita dengan peta sebaran KK miskin  adalah; Kota Tasikmalaya, Kab. Tasikmalaya, Cianjur, Garut, Ciamis, Bandung, Subang dan Majalengka. Wilayah tingkat tinggi berpotensi terkena infeksi penyakit (berdasarkan peta sebaran resiko Infeksi Penyakit dan pemanfaatan posyandu adalah: Kabupaten Purwakarta, Karawang, Bekasi, Bogor, Sukabumi, Tasikmalaya, Kota Tasikmalaya, Bekasi dan Bogor. Wilayah berpotensi rawan gizi kategori tinggi (bersumber pada 4 faktor/peta sebaran meliputi, Kabupaten Cianjur, Garut, Tasikmalaya dan Kota Tasikmalaya. Kasus Gizi bermasalah berdasarkan 3 indeks gabungan menyebar di seluruh wilayah Provinsi Jawa Barat. Wilayah kasus gizi bermasalah kategori tinggi, dan kategori sedang, sebagian besar  terjadi di wilayah Kabupaten. Baik kategori sedang maupun tinggi merupakan wilayah yang berdampingan. Gambaran ini mengarah pada fakta bahwa  masalah gizi cenderung merupakan masalah epidemiologi. Kesimpulan: Terdapat empat wilayah kabupaten status gizi yang paling serius dalam kategori tinggi meliputi, Kabupaten Cianjur, Garut, Tasikmalaya dan Kota Tasikmalaya.  Kata kunci: analisis spasial, status gizi, posyandu, rawan gizi 

  13. ANALISIS VARIABEL KEUANGAN YANG MEMPENGARUHI KEBIJAKAN DEVIDEN

    Directory of Open Access Journals (Sweden)

    Sumiadji -

    2012-03-01

    Full Text Available Penelitian ini dilakukan untuk menguji pengaruh variabel keuangan yang terdiri dari: rasio pro-fitabilitas (return on assets, likuiditas (cash ratio, rasio hutang (debt to equity ratio, market value (earnings per share, dan perputaran total aset (total assets turnover terhadap kebijakan dividen yang diproksikan dengan dividend payout ratio (DPR pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia tahun 2004-2008. Prosedur pemilihan sampel penelitian menggunakan purposive sampling sehingga menghasilkan 8 perusahaan yang memenuhi kriteria sampel. Data sekunder dikumpulkan dengan teknik dokumentasi bersumber dari Indonesian Capital Market Directory (ICMD, laporan keuangan, dan hasil Rapat Umum Pemegang Saham (RUPS. Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi linear berganda. Hasil penelitian ini adalah secara simultan variabel ROA, CR, DER, EPS dan TATO berpengaruh terhadap DPR. Secara parsial variabel yang mempengaruhi DPR adalah CR, EPS dan TATO. Varabel lainnya, yaitu ROA dan DER ditemukan tidak berpengaruh terhadap DPR. This research was conducted to examine the influence of the financial variables which consists of: return on assets (ROA, cash ratio (CR, debt to equity ratio (DER, earnings per share (EPS, and total asset turnover (TATO to the dividend policy that indicated by the dividend payout ratio (DPR of listed manufacturing company in Indonesia Stock Exchange  2004 to 2008. The sample selection procedure used was a purposive sampling so that it produced eight companies that met the sample criteria. Se-condary data was collected by the documentation technique were obtained from the Indonesian Capital Market Directory (ICMD, financial statements, and the results of the Annual General Meeting of Shareholders. The analysis technique used was multiple linear regression analysis. The research found that five variables of kind of ROA, CR, DER, EPS dan TATO simultaneously influence to dividend

  14. Tobacco smoke and the pulmonary alveolar macrophage.

    Science.gov (United States)

    Drath, D B; Davies, P; Karnovsky, M L; Huber, G L

    1979-01-01

    Our results indicate that tobacco smoke exposure to varying duration causes morphological, biochemical and functional alterations in pulmonary alveolar macrophages. The results of these changes is a population of alveolar macrophages made up of larger cells, with a reduced nucleus-cytoplasmic ratio, which are heavily loaded with heterolysosomes containing lipid. Though their fractional complement of mitochondria remains the same, an increase in the inner mitochondrial membrane surface area may be related to an enhanced oxidative metabolism. The cell is biochemically activated particularly following chronic exposure and is functionally impaired with respect to phagocytosis. PMID:232822

  15. Alveolar proteinosis: case report and literature review

    Directory of Open Access Journals (Sweden)

    2013-07-01

    Full Text Available Alveolar proteinosis is a rare disease. Its etiology, pathology, and manifestations are becoming increasingly more apparent. Few cases have been reported, which highlights the importance of reporting this case and reviewing current literature. New therapeutic options are being introduced with adequate outcomes thereby making it possible to manage patients who were previously unresponsive to conventional treatment. 25% of cases resolve spontaneously, while most patients require conventional treatment with total lung lavage that often does not improve prognosis. The case reported in this article was associated to Mycobacterium tuberculosis infection and diabetes. Primary alveolar proteinosis can have a direct relationship to these concomitant conditions.

  16. Lung Transplant Recipient with Pulmonary Alveolar Proteinosis

    Directory of Open Access Journals (Sweden)

    Sofya Tokman

    2016-01-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a progressive lung disease characterized by accumulated surfactant-like lipoproteinaceous material in the alveoli and distal bronchioles. This accumulation is the result of impaired clearance by alveolar macrophages. PAP has been described in 11 solid organ transplant recipients, 9 of whom were treated with mammalian target of rapamycin inhibitors. We report a case of a lung transplant recipient treated with prednisone, mycophenolate mofetil (MMF, and tacrolimus who ultimately developed PAP, which worsened when MMF was replaced with everolimus.

  17. Lung Transplant Recipient with Pulmonary Alveolar Proteinosis.

    Science.gov (United States)

    Tokman, Sofya; Hahn, M Frances; Abdelrazek, Hesham; Panchabhai, Tanmay S; Patel, Vipul J; Walia, Rajat; Omar, Ashraf

    2016-01-01

    Pulmonary alveolar proteinosis (PAP) is a progressive lung disease characterized by accumulated surfactant-like lipoproteinaceous material in the alveoli and distal bronchioles. This accumulation is the result of impaired clearance by alveolar macrophages. PAP has been described in 11 solid organ transplant recipients, 9 of whom were treated with mammalian target of rapamycin inhibitors. We report a case of a lung transplant recipient treated with prednisone, mycophenolate mofetil (MMF), and tacrolimus who ultimately developed PAP, which worsened when MMF was replaced with everolimus. PMID:27213073

  18. Selective alveolar corticotomy to intrude overerupted molars.

    Science.gov (United States)

    Oliveira, Dauro Douglas; de Oliveira, Bruno Franco; de Araújo Brito, Helio Henrique; de Souza, Margareth Maria Gomes; Medeiros, Paulo José

    2008-06-01

    Orthodontic intrusion of overerupted molars in adults is challenging for most clinicians. Efficient intrusion can be achieved by combining selective alveolar corticotomies with a modified full-coverage maxillary splint to reduce surgical risks, treatment time, and costs for both orthodontists and patients. PMID:18538256

  19. Iatrogenic injury to the inferior alveolar nerve

    DEFF Research Database (Denmark)

    Hillerup, Søren

    2008-01-01

    The purpose of this prospective, non-randomised, descriptive study is to characterise the neurosensory deficit and associated neurogenic discomfort in 52 patients with iatrogenic injury to the inferior alveolar nerve (IAN). All patients were examined and followed up according to a protocol...

  20. Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis

    OpenAIRE

    Malur Anagha; Kavuru Mani S; Marshall Irene; Barna Barbara P; Huizar Isham; Karnekar Reema; Thomassen Mary

    2012-01-01

    Abstract Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) and the PPARγ-regulated ATP binding cassette (ABC) lipid transpor...

  1. Secondary pulmonary alveolar proteinosis in hematologic malignancies.

    Science.gov (United States)

    Chaulagain, Chakra P; Pilichowska, Monika; Brinckerhoff, Laurence; Tabba, Maher; Erban, John K

    2014-12-01

    Pulmonary alveolar proteinosis (PAP), characterized by deposition of intra-alveolar PAS positive protein and lipid rich material, is a rare cause of progressive respiratory failure first described by Rosen et al. in 1958. The intra-alveolar lipoproteinaceous material was subsequently proven to have been derived from pulmonary surfactant in 1980 by Singh et al. Levinson et al. also reported in 1958 the case of 19-year-old female with panmyelosis afflicted with a diffuse pulmonary disease characterized by filling of the alveoli with amorphous material described as "intra-alveolar coagulum". This is probably the first reported case of PAP in relation to hematologic malignancy. Much progress has been made on PAP first described by Rosen which is currently classified as idiopathic or primary or autoimmune PAP. Idiopathic PAP occurs as a result of auto-antibodies directed against granulocyte-macrophage colony stimulating factor (GM-CSF) impeding the surfactant clearing function of alveolar macrophages leading to progressive respiratory failure. Whole lung lavage and GM-CSF therapy has improved outcomes in patients with idiopathic PAP. Despite major advancement in the management of hematologic malignancy and its complications, little is known about the type of PAP first described by Levinson and now known as secondary PAP; a term also used when PAP occurs due to other causes such as occupational dusts. In this article we review and analyze the limited literature available in secondary PAP due to hematologic malignancies and present a case of PAP associated with chronic lymphocytic leukemia successfully treated with bendamustine and rituximab. PMID:25300566

  2. ANALISIS GEN HAEMAGGLUTININ PADA VIRUS CAMPAK LIAR

    Directory of Open Access Journals (Sweden)

    Subangkit Subangkit

    2015-05-01

    Full Text Available AbstrakPenyakit Campak disebabkan oleh virus campak yang termasuk genus Morbilivirus dan Family Paramyxoviridae. Penyakit campak masih menjadi masalah kesehatan karena masih ditemukan Kejadian Luar Biasa (KLB di Indonesia. Salah satu penyebab terjadinya KLB tersebut diduga sebagaiakibat perbedaan antigenesitas antara strain vaksin yang digunakan dengan strain virus campak liar yang beredar di Indonesia. Penelitian ini bertujuan mendapatkan gambaran tentang karakteristik genetik gen Haemagglutinin virus campak liar yang ada di Indonesia. Spesimen yang digunakan sebanyak 27 isolat virus penyebab KLB dari 17 propinsi selama periode tahun 2003-2010. Isolat virus dilakukan pemeriksaan secara RT-PCR dan sekuensing dengan metode Sanger. Hasil sekuensing dianalisis dengan menggunakan perangkat lunak Bioedit 7.0 dan MEGA 4.0. Hasil penelitian didapatkan perbedaan 10 asam amino antara virus campak strain vaksin CAM-70 dan virus campak liar pada posisi D416N; K424T; V451M; N455T; V466I; I473T; F476L; Y481S atau Y481N; H495N; G505D. Kesimpulan penelitian ini adalah terdapat perbedaan karakteristik genetik antara virus campak liar di Indonesia berbeda dengan strain virus vaksin CAM-70.Kata kunci : Campak, Analisis Molekuler, Hemagglutinin, CD46AbstractMeasles is caused by virus belonging to the genus Morbilivirus and Family Paramyxoviridae. Measles is still a public health problem because outbreak of measles still found in Indonesia. Outbreak is suspected as a result of differences in antigenicity between vaccine strains used with wild-type measles virus strains circulating in Indonesia. This study aims to get genetic characteristics of wild-type measles virus haemagglutinin gene in Indonesia. The specimens were used 27 viral isolates from 17 provinces period 2003-2010. Viral isolates examined by RT-PCR and sequencing with Sanger method. Sequencing analysis were conducted using Bioedit 7.0 and MEGA 4.0 software. The results showed 10 amino acid differences

  3. ANALISIS MODEL KEPUASAN TERHADAP PEMBELIAN ULANG

    Directory of Open Access Journals (Sweden)

    Naili Farida

    2014-09-01

    Full Text Available Tujuan penelitian ini yaitu untuk menguji pengaruh brand equity, nilai pelanggan dan lifestyle yang dimediasi kepuasan konsumen terhadap pembelian ulang produk gadget di Kota Semarang. Responden dalam penelitian ini adalah seluruh konsumen yang telah melakukan pembelian produk gadget merek Samsung, sebanyak 120 orang. Teknik sampling yang digunakan yaitu purposive sampling. Teknik analisis yang digunakan yaitu Partial Least Square (PLS. Hasil penelitian menunjukkan bahwa terdapat pengaruh brand equity terhadap kepuasan, namun dalam konteks lifestyle dan nilai pelanggan tidak ada pengaruh terhadap kepuasan. Sedangkan kepuasan menunjukkan adanya pengaruh terhadap pembelian ulang. Diharapkan dari hasil penelitian ini mampu meningkatkan pembelian ulang melalui brand equity, lifestyle dan nilai pelanggan dalam konteks kepuasan. The objective of the research was to test the influence of brand equity, customer value and lifestyle which were mediated by consumer satisfaction toward re-purchasing of gadget products in Semarang. The respondents of the study were all consumers who have purchased Samsung gadget products. It was a purposive sampling study with 120 respondents. The data were analyzed by Partial Least Square (PLS. The result of the study showed that there was an influence of brand equity toward satisfaction, but in the lifestyle context and customer value did not give any influence toward satisfaction. Whereas; the satisfaction gave influence toward re-purchase. It is expected that this study can increase the repurchasethrough brand equity, lifestyle and customer values in the satisfaction context.

  4. Analisis SWOT untuk Penentuan Strategi Optimalisasi Infrastruktur

    Directory of Open Access Journals (Sweden)

    Sri Wahyuningsih

    2012-12-01

    Full Text Available Undang-undang No.38 tahun 2009 tentang Pos memberikan keleluasaan penyelenggara pos untuk melakukan pengembangan produksi serta peningkatan infrastruktur, yang mendukung daya saing masing-masing penyelenggara pos. Sebagai badan usaha milik negara, PT.Pos Indonesia memiliki jaringan terintegrasi sampai ke pedesaan dan daerah transmigrasi, yang diketahui hampir 100% jaringan dibangun oleh pemerintah. Jaringan Pos adalah jaringan fisik maupun virtual untuk mendukung terselenggaranya layanan pos. Jumlah titik layanan mencapai 24 ribu titik layanan yang menjangkau hampir 100% kecamatan dan 42 % kelurahan/desa. Untuk mengetahui strategi dalam rangka optimalisasi infrastruktur di PT.Pos Indonesia, dilakukan penelitian dengan pendekatan kualitatif dan analisis SWOT dan hasilnya penggambaran pada Matrik Grand Strategi, posisi pada  Kuadran I (positif, positif, artinya, PT.Pos Indonesia khususnya untuk KPRK Jakarta Pusat10000, KPRK Jakarta Utara14000 dan KPRK Bandung 40000 manajemen organisasinya sudah solid, dan banyak mempunyai peluang. Ekspansi dapat dilanjutkan untuk memperbesar pertumbuhan dan pengembangan produk, namun aspek SDM masih perlu ditingkatkan.

  5. ANALISIS PERBANDINGAN SPAP, IAS DAN SPKN

    Directory of Open Access Journals (Sweden)

    Maylia Pramono Sari

    2012-03-01

    Full Text Available Dalam mewujudkan Good Goveronance  akan dilakukan analisis perbandingan mengenai standar pemeriksaan nasional yaitu SPAP, ISA, dan SPKN untuk menemukan standar yang lebih tepat dan lebih lengkap untuk pemeriksaan sektor publik. Persamaan SPKN dan ISS  adalah tanggungjawab manajemen dan tanggungjawab auditor sedangkan perbedaannya adalah badan yang menerbitkannya. Perbedaan yang mendasar terletak pada karakter pemeriksaan BPK. Karakter tersebut adalah keharusan pemeriksa BPK untuk merancang prosedur pemeriksaan terhadap kepatuhan yang terkait dengan pemeriksaan yang dilakukan dan waspada atas penyimpangan lainnya. Abstract To realize Good Governance, it needs a comparative analysis for finding out the national standardization of SPAP, ISA, and SPKN . It is used for auditing public sector. SPKN and ISA have similarities and difference. Both SPKN and ISA have the same responsibility of management and audit. SPKN and ISA  have different characteristics in auditing. The compliance of audit procedure is obligatory for  BPK. Moreover, it becomes the strength of BPK RI and the one that make BPK and KAP different.Keywords: SPAP; ISA; SPKN

  6. Analisis Tingkat Kesejahteraan Masyarakat Pesisir Di Kecamatan Medan Labuhan

    OpenAIRE

    Ismail, Fakhri

    2013-01-01

    Tujuan penelitian ini adalah mengetahui tingkat kesejahteraan masyarakat pesisir di Kecamatan Medan Labuhan dengan menggunakan data primer untuk 100 responden yang mewakili seluruh populasi masyarakat pesisir di Kecamatan Medan Labuhan. Pengumpulan data dilakukan dengan menggunakan daftar kuesioner. Metode analisis yang digunakan adalah deskriptif kualitatif. Data yang terkumpul diolah dan disajikan dalam bentuk tabel Hasil penelitian menunjukkan bahwa masyarakat pesisir di Kecamatan Meda...

  7. Un’analisi strutturale: Il corvo bianco di P. Bigongiari

    Directory of Open Access Journals (Sweden)

    Luciano Vitacolonna

    2011-12-01

    Full Text Available Presentiamo qui un'analisi strutturale della lirica Il corvo bianco di Piero Bigongiari. Vengono così messi in luce sia gli strati del testo, sia le relazioni intra- e intertestuali. Attraverso lo scandaglio degli aspetti compositivi della poesia ne proponiamo infine una complessiva lettura simbolica.

  8. Analisis Desain Layar 3D Menggunakan Pengujian Pada Wind Tunnel

    Directory of Open Access Journals (Sweden)

    Danang Priambada

    2012-09-01

    Full Text Available Jurnal ini merupakan hasil analisis design layar menggunakan konsep dasar NACA 0012 dengan memprediksi perilaku dinamika fluida pada model layar rigid. Sarana yang dapat digunakan untuk memprediksi perilaku fluida udara yaitu menggunakan pengujian model pada wind tunnel. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh bentuk layar dengan faktor variasi desain berupa perbedaan penampang samping layar dengan aspek ratio yang sama serta pengaruh sudut serang terhadap gaya dorong yang dihasilkan. Analisis data dilakukan melalui pengujian wind tunnel subsonic. Pengujian dilakukan pada sudut serang 10ο, 15ο, 20ο. Dari pengujian model layar pada wind tunnel subsonic akan dihasilkan data-data yang berpengaruh pada pada layar seperti lift, drag, dan gaya resultan. Sehingga dapat dilakukan analisis terhadap model layar untuk mendapatkan desain layar yang memiliki gaya dorong yang paling optimal. Berdasarkan analisis dari wind tunnel maka didapatkan titik Stall pada sudut serang 15ο. Nilai koefisien lift terbesar terjadi pada model 3 sudut serang 15ο. Efisiensi layar terbesar juga terjadi pada model 3 yaitu sebesar 5,149.

  9. Analisis Investasi pada Proyek Pembangunan Apartemen Bale Hinggil Surabaya

    Directory of Open Access Journals (Sweden)

    Ofianto Ofianto Wahyudhi

    2014-03-01

    Full Text Available Pertumbuhan penduduk Surabaya dari tahun ke tahun terus mengalami peningkatan. Hal ini berpengaruh terhadap meningkatnya kebutuhan tempat tinggal yang layak. Maka dari itu salah satu developer PT Tlatah Gema Nugraha ingin membangun sebuah  hunian vertikal yang bernama Apartemen Bale Hinggil. Beberapa analisis sangat diperlukan melihat dari peningkatan pembangunan apartemen di Surabaya yang begitu pesat, membuat tingkat persaingan menjadi tinggi. Selain itu kecenderungan okupansi apartemen yang terus-menerus  menurun sekarang ini. Tugas akhir ini bertujuan  untuk  mendapatkan alternatif pendapatan  yang optimal dari pemilihan alternatif pendapatan antara apartemen sewa, apartemen jual, dan gabungan keduanya. Untuk penilaian alternatif sistem pendapatan digunakan analisis aruskan dengan penilaian kelayakan investasi menggunakan metode NPW dan IRR. Pada analisis kelayakan investasi didapatkan nilai NPV dan IRR tertinggi pada sistem jual yaitu sebesar Rp155.907.406.750,-  untuk NPV dan 46,62% untuk IRR. Untuk analisis sensitivitas menunjukkan alternatif pendapatan pada sistem jual merupakan alternatif yang memiliki rentan lebih aman terhadap kelayakannya jika terjadi perubahan variabel investasi. Sedangkan untuk alternatif pendapatan pada sistem gabungan memiliki tingkat sensitivitas tinggi sehingga jika terjadi perubahan variabel investasi dapat membuat alternatif pendapatan dengan sistem gabungan menjadi tidak layak.

  10. Rare Lung Diseases II: Pulmonary Alveolar Proteinosis

    Directory of Open Access Journals (Sweden)

    Stephen C Juvet

    2008-01-01

    Full Text Available The present article is the second in a series on rare lung diseases. It focuses on pulmonary alveolar proteinosis (PAP, a disorder in which lipoproteinaceous material accumulates in the alveolar space. PAP was first described in 1958, and for many years the nature of the material accumulating in the lungs was unknown. Major insights into PAP have been made in the past decade, and these have led to the notion that PAP is an autoimmume disorder in which autoantibodies interfere with signalling through the granulocyte-macrophage colony-stimulating factor receptor, leading to macrophage and neutrophil dysfunction. This has spurred new therapeutic approaches to this disorder. The discussion of PAP will begin with a case report, then will highlight the classification of PAP and review recent insights into the pathogenesis of PAP. The approach to therapy and the prognosis of PAP will also be discussed.

  11. Pulmonary alveolar proteinosis and aluminum dust exposure

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.R.; Churg, A.M.; Hutcheon, M.; Lom, S.

    1984-08-01

    A 44-yr-old male presented shortness of breath, diffuse X-ray infiltrates, and physiologic evidence of a restrictive lung disease. Biopsy revealed pulmonary alveolar proteinosis. The patient had worked for the previous 6 yr as an aluminum rail grinder in a very dusty environment. Analysis of his lung tissue revealed greater than 300 X 10(6) particles of aluminum/g dry lung; all of the particles appeared as spheres of less than 1 mu diameter. We believe that this case represents an example of pulmonary alveolar proteinosis induced by inhalation of aluminum particles; this finding confirms animal studies which suggest that proteinosis can be produced by very large doses of many types of finely divided mineral dust.

  12. Treatment of Adult Primary Alveolar Proteinosis.

    Science.gov (United States)

    Rodríguez Portal, José Antonio

    2015-07-01

    Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of surfactant-like lipoproteinaceous material in the distal air spaces and terminal bronchi, which may lead to impaired gas exchange. This accumulation of surfactant is due to decreased clearance by the alveolar macrophages. Its primary, most common form, is currently considered an autoimmune disease. Better knowledge of the causes of PAP have led to the emergence of alternatives to whole lung lavage, although this is still considered the treatment of choice. Most studies are case series, often with limited patient numbers, so the level of evidence is low. Since the severity of presentation and clinical course are variable, not all patients will require treatment. Due to the low level of evidence, some objective criteria based on expert opinion have been arbitrarily proposed in an attempt to define in which patients it is best to initiate treatment. PMID:25896950

  13. Silver Nanoparticles in Alveolar Bone Surgery Devices

    Directory of Open Access Journals (Sweden)

    Stefano Sivolella

    2012-01-01

    Full Text Available Silver (Ag ions have well-known antimicrobial properties and have been applied as nanostrategies in many medical and surgical fields, including dentistry. The use of silver nanoparticles (Ag NPs may be an option for reducing bacterial adhesion to dental implant surfaces and preventing biofilm formation, containing the risk of peri-implant infections. Modifying the structure or surface of bone grafts and membranes with Ag NPs may also prevent the risk of contamination and infection that are common when alveolar bone augmentation techniques are used. On the other hand, Ag NPs have revealed some toxic effects on cells in vitro and in vivo in animal studies. In this setting, the aim of the present paper is to summarize the principle behind Ag NP-based devices and their clinical applications in alveolar bone and dental implant surgery.

  14. Bilateral stony lung: pulmonary alveolar microlithiasis.

    Science.gov (United States)

    Chandra, Subhash; Mohan, Anant; Guleria, Randeep; Das, Prasenjit; Sarkar, Chitra

    2009-01-01

    A 40-year-old male paddy field worker was referred for exertional shortness of breath and non-productive cough for 4 years. He had been treated for pulmonary tuberculosis twice. Chest radiograph showed extensive bilateral nodular opacities ("sandstorm-like") in the middle and lower lobe. Pulmonary function tests revealed a restrictive ventilatory defect. High resolution CT showed widespread nodular infiltration with "crazy paving" appearance and interrupted black pleura sign. This was confirmed as pulmonary alveolar microlithiasis (PAM) by trans-bronchial lung biopsy, which showed normal respiratory lining epithelium with dilated alveolar spaces containing many calcific bodies, some of which showed concentric calcification. The possibilities of silicosis (due to exposure to husk) and tuberculosis, both of which can mimic PAM clinically and radiologically, made this case a diagnostic challenge. PMID:21686505

  15. Bmp2 and Bmp4 accelerate alveolar bone development.

    Science.gov (United States)

    Ou, Mingming; Zhao, Yibing; Zhang, Fangming; Huang, Xiaofeng

    2015-06-01

    Alveolar bone remodeling is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking. This study aims at improving our understanding of alveolar bone formation and the role of bone morphogenetic proteins (Bmps) in this process. Mice at embryonic (E) day 13.5 to postnatal (PN) day 15.5 were selected to observe the process of alveolar bone development. Alveolar bone development was found to be morphologically observable at E14.5. Molar teeth isolated from mice at PN7.5 were pretreated with Bmp2, Bmp4, Noggin, or BSA, and grafted subcutaneously into mice. The subcutaneously implanted tooth germs formed alveolar bone indicating the role of the dental follicle in alveolar bone development. Alveolar bone formation was increased after pretreatment with Bmp2 and Bmp4, but not with Noggin. Gene expression levels in dental follicle cells from murine molars were also determined by real-time RT-PCR. The expression levels of Runx2, Bsp, and Ocn were significantly higher in dental follicle cells cultured with Bmp2 or Bmp4, and significantly lower in those cultured with Noggin when compared with that of the BSA controls. Our results suggest that the dental follicle participates in alveolar bone formation and Bmp2/4 appears to accelerate alveolar bone development.

  16. Alveolar ridge augmentation by osteoinduction in rats

    DEFF Research Database (Denmark)

    Pinholt, E M; Bang, G; Haanaes, H R

    1990-01-01

    The purpose of this study was to evaluate bone substitutes for alveolar ridge augmentation by osteoinduction. Allogenic, demineralized, and lyophilized dentin and bone was tested for osteoinductive properties in order to establish an experimental model for further studies. Implantations were...... performed subperiosteally on the premaxilla and heterotopically in the abdominal muscles of rats. Light microscopic evaluations revealed that all allogenic, demineralized, and lyophilized dentin and bone implants induced new bone formation. No inflammatory or foreign body reactions were observed....

  17. Phagocytic properties of lung alveolar wall cells

    Directory of Open Access Journals (Sweden)

    Tanaka,Akisuke

    1974-04-01

    Full Text Available For the purpose to define the mechanism of heavy metal intoxication by inhalation, morphologic observations were made on rat lungs after nasal instillation of iron colloid particles of positive and negative electric charges. Histochemical observation was also made on the liver and spleen of these animals. The instilled iron colloid particles reach the alveolar cavity easily, as can be seen in the tissue sections stained by Prussian blue reaction. Alveolar macrophages do take up them avidly both of positive and negative charges, though much less the positive particles than negative ones. In contrast, the alveolar epithelial cells take up solely positive particles by phagocytosis but not negative ones. Electron microscope observation revealed that the positive particles are ingested by Type I epithelial cells by pinocytosis and by Type II cells by phagocytosis as well. Then the iron colloid particles are transferred into the basement membrane by exocytosis. Travelling through the basement membrane they are again taken up by capillary endothelial cells by phagocytosis. Some particles were found in the intercellular clefts of capillary endothelial cells but not any iron colloid particles in the intercellular spaces of epithelial cells and in the capillary lumen. However, the liver and spleen tissues of the animals given iron colloid showed a strong positive iron reaction. On the basis of these observations, the mechanism of acute intoxication by inhaling heavy metal dusts like lead fume is discussed from the view point of selective uptake of alveolar epithelial and capillary endothelial cells for the particles of the positive electric cha'rge.

  18. In situ methods for assessing alveolar mechanics.

    Science.gov (United States)

    Wu, You; Perlman, Carrie E

    2012-02-01

    Lung mechanics are an important determinant of physiological and pathophysiological lung function. Recent light microscopy studies of the intact lung have furthered the understanding of lung mechanics but used methodologies that may have introduced artifacts. To address this concern, we employed a short working distance water immersion objective to capture confocal images of a fluorescently labeled alveolar field on the costal surface of the isolated, perfused rat lung. Surface tension held a saline drop between the objective tip and the lung surface, such that the lung surface was unconstrained. For comparison, we also imaged with O-ring and coverslip; with O-ring, coverslip, and vacuum pressure; and without perfusion. Under each condition, we ventilated the lung and imaged the same region at the endpoints of ventilation. We found use of a coverslip caused a minimal enlargement of the alveolar field; additional use of vacuum pressure caused no further dimensional change; and absence of perfusion did not affect alveolar field dimension. Inflation-induced expansion was unaltered by methodology. In response to inflation, percent expansion was the same as recorded by all four alternative methods. PMID:22074721

  19. Pulmonary alveolar proteinosis: time to shift?

    Science.gov (United States)

    Papiris, Spyros A; Tsirigotis, Panagiotis; Kolilekas, Likurgos; Papadaki, Georgia; Papaioannou, Andriana I; Triantafillidou, Christina; Papaporfyriou, Anastasia; Karakatsani, Anna; Kagouridis, Konstantinos; Griese, Matthias; Manali, Effrosyni D

    2015-06-01

    Pulmonary alveolar proteinosis (PAP) is categorized into hereditary, secondary and autoimmune PAP (aPAP) types. The common pathogenesis is the ability of the alveolar macrophages to catabolize phagocytized surfactant is affected. Hereditary PAP is caused by mutations involving the GM-CSF signaling, particularly in genes for the GM-CSF receptor and sometimes by GATA2 mutations. Secondary PAP occurs in hematologic malignancies, other hematologic disorders, miscellaneous malignancies, fume and dust inhalation, drugs, autoimmune disorders and immunodeficiencies. aPAP is related to the production of GM-CSF autoantibodies. PAP is characterized morphologically by the inappropriate and progressive 'occupation' of the alveolar spaces by an excessive amount of unprocessed surfactant, limiting gas exchange and gradually exhausting the respiratory reserve. Myeloid cells' immunity deteriorates, increasing the risk of infections. Treatment of PAP is based on its etiology. In aPAP, recent therapeutic advances might shift the treatment option from the whole lung lavage procedure under general anesthesia to the inhalation of GM-CSF 'as needed'. PMID:25864717

  20. Claudins and alveolar epithelial barrier function in the lung

    OpenAIRE

    Frank, James A.

    2012-01-01

    The alveolar epithelium of the lung constitutes a unique interface with the outside environment. This thin barrier must maintain a surface for gas transfer while being continuously exposed to potentially hazardous environmental stimuli. Small differences in alveolar epithelial barrier properties could therefore have a large impact on disease susceptibility or outcome. Moreover, recent work has focused attention on the alveolar epithelium as central to several lung diseases, including acute lu...

  1. Pulmonary Surfactant Surface Tension Influences Alveolar Capillary Shape and Oxygenation

    OpenAIRE

    Ikegami, Machiko; Weaver, Timothy E.; Grant, Shawn N.; Whitsett, Jeffrey A.

    2009-01-01

    Alveolar capillaries are located in close proximity to the alveolar epithelium and beneath the surfactant film. We hypothesized that the shape of alveolar capillaries and accompanying oxygenation are influenced by surfactant surface tension in the alveolus. To prove our hypothesis, surfactant surface tension was regulated by conditional expression of surfactant protein (SP)-B in Sftpb−/− mice, thereby inhibiting surface tension–lowering properties of surfactant in vivo within 24 hours after d...

  2. Alveolar epithelial type II cell: defender of the alveolus revisited

    OpenAIRE

    Fehrenbach Heinz

    2001-01-01

    Abstract In 1977, Mason and Williams developed the concept of the alveolar epithelial type II (AE2) cell as a defender of the alveolus. It is well known that AE2 cells synthesise, secrete, and recycle all components of the surfactant that regulates alveolar surface tension in mammalian lungs. AE2 cells influence extracellular surfactant transformation by regulating, for example, pH and [Ca2+] of the hypophase. AE2 cells play various roles in alveolar fluid balance, coagulation/fibrinolysis, a...

  3. Alveolar pressure during high-frequency jet ventilation

    OpenAIRE

    Vught, Adrianus; Versprille, Adrian; Jansen, Jos

    1990-01-01

    textabstractWe studied the influence of ventilatory frequency (1-5 Hz), tidal volume, lung volume and body position on the end-expiratory alveolar-to-tracheal pressure difference during high-frequency jet ventilation (HFJV) in Yorkshire piglets. The animals were anesthetized and paralysed. Alveolar pressure was estimated with the clamp off method, which was performed by a computer controlled ventilator and which had been extensively tested on its feasibility. The alveolar-to-tracheal pressure...

  4. Pulmonary Alveolar Proteinosis in Children: A case series

    OpenAIRE

    seyyed Ahmad Tabatabaei; abdollah karimi; Sedigheh Rafiee Tabatabaei; B Radpay; Farzaneh Jadali

    2010-01-01

    Pulmonary Alveolar Proteinosis(PAP) is a rare disease of unknown etiology, characterized by the accumulation of proteinoceous material in the alveoli that is rich in lipid and is positive on periodic acid-Schiff(PAS) stain. PAP is rare in children. Two forms are encountered in pediatric practice: congenital alveolar proteinosis (CAP) and a later–onset form that is generally less severe. Broncho-alveolar lavage is the key to diagnosis. Therapeutic lung lavages are the only effective treatment ...

  5. ANALISIS FAKTOR DAYA SAING DI KABUPATEN SEMARANG

    Directory of Open Access Journals (Sweden)

    Eka Handriani

    2010-03-01

    Full Text Available Jika perusahaan dapat mengoptimalkan penggunaan sumberdaya maka perusahaan mampu menghasilkan sustained competitive advantage. Tujuan dari penelitian ini adalah untuk membuktikan bahwa faktor internal dan eksternal, keterampilan pengusaha dan strategi yang diterapkan dalam UKM Kabupaten Semarang berpengaruh terhadap keunggulan kompetitif baik secara simultan dan parsial. Pengusaha mikro memiliki potensi besar dalam ekonomi nasional dan lokal sesuai dengan periode pasar bebas. Namun, etos dan persaingan masih dalam tingkat rendah. Penyebab utama dari masalah ini berasal dari faktor tenaga lingkungan, di antaranya adalah faktor internal dan eksternal keterampilan pengusaha, strategi, dan etos. Sebuah strategi yang akurat diperlukan untuk memecahkan masalah ini. Penelitian ini dilakukan pada 60 pengusaha mikro melalui empat variabel dependen dan satu variabel independen dengan menggunakan alat analisis statistik program SPSS. Hasilnya menunjukkan bahwa faktor internal dan eksternal, keterampilan pengusaha, strategi dan etos telah signifikan berpengaruh pada keunggulan kompetitif yang diterapkan oleh pengusaha mikro di Kabupaten Semarang secara parsial maupun simultan. The purpose of this research is to attest that internal and external factor, entrepreneur skill and strategy which applied in the UKM of Kabupaten Semarang are influence to the competitive advantage simultaneously and partially. Micro entrepreneur has great potency in the national and local economic according to this free market period. However, it is ethos and competition still in the low level. The main cause of this problem come up from environmental exertion factor, among them are internal and external factor the entrepreneur skill, strategy, and ethos. An accurate strategy is needed to solve this problem. This research has been done on 60 micro entrepreneurs through four dependent variables and one independent variable using to SPSS statistic program. The result shown that

  6. Isolation and Culture of Human Alveolar Type II Pneumocytes.

    Science.gov (United States)

    Witherden, I R; Tetley, T D

    2001-01-01

    Alveolar type II pneumocytes (alveolar type II cells; TII cells) play an important role in the homeostasis of the alveolar unit. They are the progenitor cells to the type I pneumocyte and are therefore responsible for regeneration of alveolar epithelium following alveolar epithelial cell damage. The type I cell covers over 90% of the alveolar surface, reflecting its capacity to stretch into a flattened cell with very little depth (approx. 0.1 µm), but with a large surface area, to facilitate gas exchange. Nevertheless, the type II cell outnumbers type I cells, estimated to be by 2:1 in rodents. Most of the type II cell lies buried in the interstitium of the alveolus, with only the apical tip of the cell reaching into the airspace, through which another crucial function, provision of alveolar surfactant, occurs. Surfactant synthesis and secretion is a unique feature of type II cells; surfactant consists of a high proportion of phospholipids (approx. 90%) and a small proportion of protein (approx. 10%), which contains surfactant apoprotein (SP), of which four have so far been described, SP-A, SP-B, SP-C, and SP-D (1,2). Surfactant is highly surface active and is essential to prevent alveolar collapse. In addition, surfactant has many other roles, including pulmonary host defense. Compromised surfactant synthesis and function are believed to be a feature of numerous disease states (1,2), including infant respiratory distress syndrome, adult respiratory distress syndrome, alveolar proteinosis, and microbial infection. PMID:21336897

  7. Characteristic aspects of alveolar proteinosis diagnosis Aspectos característicos do diagnóstico da proteinose alveolar

    OpenAIRE

    Thiago Prudente Bártholo; José Gustavo Pugliese; Luiz Carlos Aguiar Vaz; Cláudia Henrique da Costa; Rogério Rufino

    2012-01-01

    Alveolar proteinosis is an uncommon pulmonary disease characterized by an accumulation of surfactant in terminal airway and alveoli, thereby impairing gas exchange and engendering respiratory insufficiency in some cases. Three clinically and etiologically distinct forms of pulmonary alveolar proteinosis are recognized: congenital, secondary and idiopathic, the latter corresponding to 90% of the cases. In this case report we present a young male patient that was diagnosed with alveolar protein...

  8. Segment distraction to reduce a wide alveolar cleft before alveolar bone grafting.

    NARCIS (Netherlands)

    Binger, T.; Katsaros, C.; Rucker, M.; Spitzer, W.J.

    2003-01-01

    OBJECTIVE: To demonstrate a method for reduction of wide alveolar clefts prior to bone grafting. This method aims to facilitate bone grafting and achieve adequate soft tissue coverage of the graft with attached gingiva. CASE REPORT: Treatment of a patient with bilateral cleft lip and palate with a s

  9. Nostril Base Augmentation Effect of Alveolar Bone Graft

    Directory of Open Access Journals (Sweden)

    Woojin Lee

    2013-09-01

    Full Text Available Background The aims of alveolar bone grafting are closure of the fistula, stabilization ofthe maxillary arch, support for the roots of the teeth adjacent to the cleft on each side.We observed nostril base augmentation in patients with alveolar clefts after alveolar bonegrafting. The purpose of this study was to evaluate the nostril base augmentation effect ofsecondary alveolar bone grafting in patients with unilateral alveolar cleft.Methods Records of 15 children with alveolar clefts who underwent secondary alveolar bonegrafting with autogenous iliac cancellous bone between March of 2011 and May of 2012 werereviewed. Preoperative and postoperative worm’s-eye view photographs and reconstructedthree-dimensional computed tomography (CT scans were used for photogrammetry. Thedepression of the nostril base and thickness of the philtrum on the cleft side were measuredin comparison to the normal side. The depression of the cleft side pyriform aperture wasmeasured in comparison to the normal side on reconstructed three-dimensional CT.Results Significant changes were seen in the nostril base (P=0.005, the philtrum length(P=0.013, and the angle (P=0.006. The CT measurements showed significant changes in thepyriform aperture (P<0.001 and the angle (P<0.001.Conclusions An alveolar bone graft not only fills the gap in the alveolar process but alsoaugments the nostril base after surgery. In this study, only an alveolar bone graft was performedto prevent bias from other procedures. Nostril base augmentation can be achieved byperforming alveolar bone grafts in children, in whom invasive methods are not advised.

  10. An estimation of mechanical stress on alveolar walls during repetitive alveolar reopening and closure.

    Science.gov (United States)

    Chen, Zheng-Long; Song, Yuan-Lin; Hu, Zhao-Yan; Zhang, Su; Chen, Ya-Zhu

    2015-08-01

    Alveolar overdistension and mechanical stresses generated by repetitive opening and closing of small airways and alveoli have been widely recognized as two primary mechanistic factors that may contribute to the development of ventilator-induced lung injury. A long-duration exposure of alveolar epithelial cells to even small, shear stresses could lead to the changes in cytoskeleton and the production of inflammatory mediators. In this paper, we have made an attempt to estimate in situ the magnitudes of mechanical stresses exerted on the alveolar walls during repetitive alveolar reopening by using a tape-peeling model of McEwan and Taylor (35). To this end, we first speculate the possible ranges of capillary number (Ca) ≡ μU/γ (a dimensionless combination of surface tension γ, fluid viscosity μ, and alveolar opening velocity U) during in vivo alveolar opening. Subsequent calculations show that increasing respiratory rate or inflation rate serves to increase the values of mechanical stresses. For a normal lung, the predicted maximum shear stresses are surface tension or viscosity, the maximum shear stress will notably increase, even at a slow respiratory rate. Similarly, the increased pressure gradients in the case of elevated surface or viscosity may lead to a pressure drop >300 dyn/cm(2) across a cell, possibly inducing epithelial hydraulic cracks. In addition, we have conceived of a geometrical model of alveolar opening to make a prediction of the positive end-expiratory pressure (PEEP) required to splint open a collapsed alveolus, which as shown by our results, covers a wide range of pressures, from several centimeters to dozens of centimeters of water, strongly depending on the underlying pulmonary conditions. The establishment of adequate regional ventilation-to-perfusion ratios may prevent recruited alveoli from reabsorption atelectasis and accordingly, reduce the required levels of PEEP. The present study and several recent animal experiments likewise

  11. ANALISIS TINGKAT KAPABILITAS SISTEM INFORMASI RUMAH SAKIT BERDASARKAN COBIT 5 (MEA01) PADA RSUD TUGUREJO SEMARANG

    OpenAIRE

    Ariel Bagus Nugroho; Amiq Fahmi

    2015-01-01

    RSUD Tugurejo Semarang merupakan Rumah Sakit kelas B milik pemerintah Provinsi Jawa Tengah yang menyediakan pelayanan jasa untuk masyarakat. Dalam manajemen pengolahan data, RSUD Tugurejo Semarang telah menggunakan sistem informasi rumah sakit. Untuk mengetahui apakah sistem informasi telah berjalan seperti yang diharapkan, maka perlu dilakukan analisis tatakelola teknologi informasi. Pada penelitian ini analisis tatakelola teknologi informasi berfokus pada proses pengawasan, evaluasi dan pen...

  12. Particle-induced indentation of the alveolar epithelium caused by surface tension forces

    OpenAIRE

    Mijailovich, S. M.; Kojic, M.; Tsuda, A.

    2010-01-01

    Physical contact between an inhaled particle and alveolar epithelium at the moment of particle deposition must have substantial effects on subsequent cellular functions of neighboring cells, such as alveolar type-I, type-II pneumocytes, alveolar macrophage, as well as afferent sensory nerve cells, extending their dendrites toward the alveolar septal surface. The forces driving this physical insult are born at the surface of the alveolar air-liquid layer. The role of alveolar surfactant submer...

  13. ANALISIS CITRA PERMUKAAN THERMOCHROMIC LIQUID CRYSTAL BERDASARKAN NILAI STATISTIK HUE

    Directory of Open Access Journals (Sweden)

    Risti Suryantari

    2014-05-01

    Full Text Available Tujuan dari penelitian ini adalah untuk mengamati perbedaan citra pada permukaan Thermocromic Liquid Crystal (TLC R25C5W akibat perubahan temperatur. Metode yang digunakan untuk analisis adalah pengolahan citra berbasis morfologi matematika menggunakan perangkat lunak Matlab2013a. Citra asli yang diperoleh dalam bentuk RGB dikonversi menjadi HSV (hue, saturation, value, dengan mengambil komponen hue saja. Proses utama yang digunakan adalah opening dengan struktur elemen (SE line. Berdasarkan analisis visual pada citra akhir hasil pengolahan citra, tampak bahwa terdapat perbedaan setiap citra untuk berbagai temperatur berdasarkan tingkat kecerahannya. Secara kuantitatif perbedaan tersebut dapat dilihat dari nilai statistiknya. Nilai max dan mean citra hue semakin meningkat seiring dengan meningkatnya temperatur.

  14. Perawatan Pulpa Gigi Sulung Disertai Abses Dento Alveolar

    OpenAIRE

    Nasution, Nurasiah Adita

    2008-01-01

    Abses dento alveolar adalah kumputan pus yang berada pada tulang alveolar sekitar apeks gigi akibat kematian pulpa. Matinya pulpa dapat disebabkan bakteri, trauma, iritasi mekanis, termis maupun kimiawi. Pengaruh bakteri merupakan penyebab kerusakan jaringan pulpa yang terbesar. Perluasan infeksi ke dalam jaringan periapikal dapat melalui foramen apikalke jaringan periodontal sehingga terjadi inflarnasi. Bila virulensi bakteri meningkat disertai rendahnya pertahanan tubuh penderita dapat ...

  15. Alveolar pressure during high-frequency jet ventilation

    NARCIS (Netherlands)

    A.J. van Vught (Adrianus); A. Versprille (Adrian); J.R.C. Jansen (Jos)

    1990-01-01

    textabstractWe studied the influence of ventilatory frequency (1-5 Hz), tidal volume, lung volume and body position on the end-expiratory alveolar-to-tracheal pressure difference during high-frequency jet ventilation (HFJV) in Yorkshire piglets. The animals were anesthetized and paralysed. Alveolar

  16. Post-neonatal drop in alveolar SP-A expression

    DEFF Research Database (Denmark)

    Stray-Pedersen, Arne; Vege, Ashild; Stray-Pedersen, Asbjorg;

    2008-01-01

    was developed enabling semi-quantitative estimation of staining intensity and distribution. RESULTS: SP-A was detected in the terminal bronchioles and alveolar spaces of fetuses >35 weeks gestation. The intra-alveolar SP-A expression increased in the perinatal period followed by a marked drop in infants aged...

  17. Anaesthetic management of bilateral alveolar proteinosis for bronchopulmonary lavage.

    OpenAIRE

    Dixit R; Chaudhari L; Mahashur A

    1998-01-01

    The most hazardous manifestation of pulmonary alveolar proteinosis is progressive hypoxia for which bronchopulmonary lavage (BPL) is the single most effective treatment. Unfortunately this procedure under general anesthesia itself increases the risk of hypoxia due to the need for one lung ventilation. It was therefore considered interesting to report the successful anaesthetic management of a patient with pulmonary alveolar proteinosis for Bronchopulmonary lavage.

  18. Tongue-Palate Contact of Perceptually Acceptable Alveolar Stops

    Science.gov (United States)

    Lee, Alice; Gibbon, Fiona E.; O'Donovan, Cliona

    2013-01-01

    Increased tongue-palate contact for perceptually acceptable alveolar stops has been observed in children with speech sound disorders (SSD). This is a retrospective study that further investigated this issue by using quantitative measures to compare the target alveolar stops /t/, /d/ and /n/ produced in words by nine children with SSD (20 tokens of…

  19. Pulmonary alveolar proteinosis: diagnostic and therapeutic challenges

    Directory of Open Access Journals (Sweden)

    Campo Ilaria

    2012-06-01

    Full Text Available Abstract Pulmonary Alveolar Proteinosis (PAP is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals and in distinct clinical forms: autoimmune (previously referred to as the idiopathic form, represents the vast majority of PAP cases, and is associated with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF auto-antibodies; GMAbs, secondary (is a consequence of underlying disorders, congenital (caused by mutations in the genes encoding for the GM-CSF receptor, and PAP-like syndromes (disorders associated with surfactant gene mutations. The clinical course of PAP is variable, ranging from spontaneous remission to respiratory failure. Whole lung lavage (WLL is the current standard treatment for PAP patients and although it is effective in the majority of cases, disease persistence is not an unusual outcome, even if disease is well controlled by WLL. In this paper we review the therapeutic strategies which have been proposed for the treatment of PAP patients and the progress which has been made in the understanding of the disease pathogenesis.

  20. ANALISIS KEBIJAKAN PENANAMAN MODAL ASING DI KABUPATEN BANTAENG

    OpenAIRE

    RACHMAT, ANUGRAH

    2015-01-01

    2015 Anugrah Rachmat, Nomor Induk E12110255,Program Studi Ilmu Pemerintahan, Fakultas Ilmu Sosial dan Ilmu Politik, Unversitas Hasanuddin, Menyusun Skripsi dengan judul ??? Analisis Kebijakan Penanaman Modal Asing di Kabupaten Bantaeng???. Di bawah bimbingan Dr. H. Andi Gau Kadir, M.A sebagai pemimbing I dan Dr. Hj.Nurlinah, M.Si sebagai pembimbing II. Penelitian ini bertujuan untuk mengambarkan model invetasi penanaman modal asing serta mengetahui prospeknya di Kabup...

  1. ANALISIS CITRA PERMUKAAN THERMOCHROMIC LIQUID CRYSTAL BERDASARKAN NILAI STATISTIK HUE

    OpenAIRE

    Risti Suryantari; - Flaviana

    2014-01-01

    Tujuan dari penelitian ini adalah untuk mengamati perbedaan citra pada permukaan Thermocromic Liquid Crystal (TLC) R25C5W akibat perubahan temperatur. Metode yang digunakan untuk analisis adalah pengolahan citra berbasis morfologi matematika menggunakan perangkat lunak Matlab2013a. Citra asli yang diperoleh dalam bentuk RGB dikonversi menjadi HSV (hue, saturation, value), dengan mengambil komponen hue saja. Proses utama yang digunakan adalah opening dengan struktur elemen (SE) line. Berdasark...

  2. Analisis Faktor – Faktor yang mempengaruhi Pertumbuhan Ekonomi Singapura

    OpenAIRE

    Sitepu, Wilsa Road Betterment

    2012-01-01

    The thesis investigate the factors predisposing economy growth in Singapore Country with using SEM (Structural Equation Model) consisting of factor analysis, path analysis, and regression. The research can be seen from its conceptual frame included in path analyze and data processing variable through AMOS (Analisis of Moment Structures) program as the multivariate analysis with some variables. The used data was secondary data taken from annual data and interpolated per t...

  3. MODEL TES DAN ANALISIS PRESTASI BELAJAR MATEMATIK SISWA SEKOLAH DASAR

    OpenAIRE

    Zamsir Zamsir

    2013-01-01

    Penelitian ini bertujuan untuk menemukan model tes dan analisis prestasi belajar siswa yang dapat dipakai untuk melakukan identifikasi level kemampuan dan menyusun profil pencapaian kompetensi siswa, khususnya di sekolah dasar. Penelitian ini merupakan penelitian pengembangan model yang dikembangkan menyangkut dua hal, yaitu: (1) prosedur dan langkah-langkah penyusunan tes serta teknik identifikasi level kemampuan siswa, dan (2) pelaporan hasil tes. Identifikasi dilakukan dengan cara menempat...

  4. Treatment to pulmonary alveolar proteinosis with total bronchoalveolar lavage

    International Nuclear Information System (INIS)

    The pulmonary alveolar proteinosis is a rare disease with variable course and characterized by the accumulation of surfactant in the alveoli. By the treatment it was used the alveolar lavage with good results. We present the experience accumulated in the Las Americas clinic of Medellin city with the treatment of three patients with diagnosis of pulmonary alveolar proteinosis by alveolar lavage. We realized seven lavages, two of them bilateral and sequential. We didn't 't have important complications and in all cases we got good clinical and physiological results. Two patients had relapsed six and seven months after the first lavage and they needed a second lavage. We conclude that the pulmonary lavage is a secure and effective procedure in the treatment of the pulmonary alveolar proteinosis and the modality of bilateral sequential lavage is a good alternative and less expensive

  5. Contemporary Approaches in the Repair of Alveolar Clefts

    Directory of Open Access Journals (Sweden)

    Ufuk Tatli

    2014-08-01

    Full Text Available Cleft lip and palate is one of the most common craniofacial anomalies. The repair of the alveolar clefts is an important part of the treatment for patients with cleft lip and palate. The treatment concepts of alveolar bone grafting are still controversial. The corresponding controversial issues are; timing of alveolar bone grafting, graft materials, and timing of the orthodontic expansion. In the present article, aforementioned controversial issues and contemporary treatment modalities of the maxillary alveolar clefts were reviewed in the light of current literature. In conclusion, the most suitable time for alveolar bone grafting is mixed dentition period. Grafting procedure may be performed in the early or late phases of this period depending on some clinical features. Adjunct orthodontic expansion procedures should be performed before and/or after grafting depending on the patient's current features. [Archives Medical Review Journal 2014; 23(4.000: 563-574

  6. ANALISIS PELAYANAN KB MANDIRI WANITA USIA SUBUR BERDASARKAN STATUS EKONOMI

    Directory of Open Access Journals (Sweden)

    Selma Siahaan

    2013-08-01

    Full Text Available Latar belakang: Penggunaan metode keluarga berencana (KB oleh Wanita Usia Subur (WUS antara lain dipengaruhi oleh faktor sosial ekonomi. Maka, masalah biaya yang harus dibayar oleh WUS untuk memperoleh pelayanan KB perludi pahami guna keberhasilan program KB Nasional. Metode: Studi menggunakan data Riset Kesehatan Dasar (Riskesdas 2010, bertujuan untuk mengetahui biaya pelayanan KB yang dibayar oleh perempuan usia 10–59 tahun (WUS yang pernah kawin menurut metode KB berdasarkan status ekonomi yang bersangkutan. Analisis data menggunakan analisis deskriptif, analisis bivariat dengan uji statistik chi-square. Hasil: Alat/obat KB disposible terbanyak yang digunakan WUS dari semua golongan status ekonomi adalah metode KB suntik, sedangkan kondom terbanyak digunakan oleh WUS dengan status ekonomi atas banyak. Sekitar 50% WUS dengan status ekonomi (SE rendah membayar biaya pelayanan KB berkisar Rp.10.000–Rp.15.000. Sementara itu WUS dengan SE atas terbanyak membayar sekitar > Rp. 20.000. Terdapat korelasi signifikan antara metode KB dengan biaya dan status ekonomi. Kesimpulan: Metode suntik masih merupakan metode pilihan bagi WUS di Indonesia dan pemilihan metode KB oleh WUS berhubungan dengan status ekonomi mereka. Oleh karena itu promosi kesehatan perlu terus digalakkan agar program KB pemerintah dengan IUD dapat lebih dikenal dan dapat diterima masyarakat. Di samping itu, diperlukan kebijakan khusus (bantuan kepada WUS dengan status ekonomi rendah sehingga IUD dapat diperoleh secara gratis atau setidaknya dengan biaya yang terjangkau.

  7. Analisis Strategi Peningkatan Layanan Sertifikasi Perangkat Telepon Seluler

    Directory of Open Access Journals (Sweden)

    Widya Budi Andhini

    2015-03-01

    Full Text Available Standardisasi sebagai unsur penunjang pembangunan mempunyai peran penting dalam usaha optimasi pendayagunaan sumber daya.Peningkatan standarisasi dan sertifikasi perangkat telekomunikasi dilaksanakan secara aktif dalam menjaga terlaksananya interkoneksi, seperti dalam Renstra KemKominfo Tahun 2010-2014. Tujuan kegiatan standardisasi telekomunikasi antara lain menjamin interoperabilitas dan interkonektivitas, mengendalikan mutu perangkat. Untuk meningkatkan penyelenggaraan sertifikasi perangkat, dilakukan kajian yang menggambarkan analisis strategi untuk meningkatkan penyelenggaraan sertifikasi telepon seluler. Penelitian ini menggunakan pendekatan kualitatif, dengan format desain deskriptif kualitatif, pendekatan kualitatif matriks SWOT untuk menghasilkan strategi. Pengumpulan data dilakukan melalui wawancara kepada narasumber terdiri dari Direktorat Standardisasi Ditjen SDPPI, Balai Besar Pengujian Perangkat Telekomunikasi, Telkom R&D Center, kuesioner kepada pabrikan dan toko handphone. Teknis analisis data menggunakan Model Miles and Huberman, dan analisis SWOT yaitu mengidentifikasi dan menganalisis faktor Strength (kekuatan, Weakness (Kelemahan, Opportunity (Peluang dan Threat (Tantangan. Hasil pembahasan memperlihatkan strategi masing-masing kolom di matriks SWOT adalah comparative advantage meliputi Roadmap pengembangan lembaga uji, perangkat, SDM; knowledge sharing; mobilization meliputi penyusunan aturan persyaratan teknis perangkat telekomunikasi, sosialisasi, survey; Divestment/ investment : facility sharing, kompetensi SDM, sosialisasi aplikasi online; dan Damage Control meliputi penambahan SDM, uji fungsi/pretest, pertemuan rutin antara Ditstand dan Lembaga Uji.

  8. Rilievo tridimensionale e analisi dei dissesti della Pieve di Romena

    Directory of Open Access Journals (Sweden)

    Stefano Bertocci

    2015-01-01

    Full Text Available La Pieve di San Pietro a Romena si trova nel comunedi Pratovecchio, nella vallata casentinese. La sua edificazionerisale, basandosi su quanto scolpito su di uncapitello, al 1152 d.C. per volere di Matilde di Canossa,si tratta quindi di un edificio romanico, anche se dell’edificiooriginario in realtà non resta molto, anche a causadei molti terremoti che hanno interessato la vallata.Sulla base di quanto richiesto dal DM 01/2008 sulle costruzionil’analisi del monumento è stata fatta seguendovari step conoscitivi: una corretta analisi delle fonti storiched’archivio per condurre le prime ipotesi di sviluppodell’edificio, un rilievo laser scanner in modo da avereun rilievo molto affidabile. Sulla base della nuvola dipunti sono state ottenute tutte le sezioni e i prospettinecessari a descrivere l’edificio e a completare l’analisicon gli elaborati materici, dei fotopiani, dei degradi superficiali.Parallelamente si è portata avanti l’analisi stratigraficasulla pieve, utile a capire come l’edificio è statoconcepito e quali trasformazioni ha subito nel tempo, inmodo poi da impostare il progetto di restauro.

  9. Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis

    Directory of Open Access Journals (Sweden)

    Malur Anagha

    2012-06-01

    Full Text Available Abstract Rationale Pulmonary Alveolar Proteinosis (PAP patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ and the PPARγ-regulated ATP binding cassette (ABC lipid transporter, ABCG1. An open label proof of concept Phase II clinical trial was conducted in PAP patients using rituximab, a chimeric murine-human monoclonal antibody directed against B lymphocyte specific antigen CD20. Rituximab treatment decreased anti-GM-CSF antibody levels in bronchoalveolar lavage (BAL fluid, and 7/9 patients completing the trial demonstrated clinical improvement as measured by arterial blood oxygenation. Objectives This study sought to determine whether rituximab therapy would restore lipid metabolism in PAP alveolar macrophages. Methods BAL samples were collected from patients pre- and 6-months post-rituximab infusion for evaluation of mRNA and lipid changes. Results Mean PPARγ and ABCG1 mRNA expression increased 2.8 and 5.3-fold respectively (p ≤ 0.05 after treatment. Lysosomal phospholipase A2 (LPLA2 (a key enzyme in surfactant degradation mRNA expression was severely deficient in PAP patients pre-treatment but increased 2.8-fold post-treatment. In supplemental animal studies, LPLA2 deficiency was verified in GM-CSF KO mice but was not present in macrophage-specific PPARγ KO mice compared to wild-type controls. Oil Red O intensity of PAP alveolar macrophages decreased after treatment, indicating reduced intracellular lipid while extracellular free cholesterol increased in BAL fluid. Furthermore, total protein and Surfactant protein A were significantly decreased in the BAL fluid post therapy. Conclusions Reduction in GM

  10. Recent advances in alveolar biology: Evolution and function of alveolar proteins☆

    OpenAIRE

    Orgeig, Sandra; Hiemstra, Pieter S.; Edwin J A Veldhuizen; Casals, Cristina; Clark, Howard W.; Haczku, Angela; Knudsen, Lars; Possmayer, Fred

    2010-01-01

    This review is focused on the evolution and function of alveolar proteins. The lung faces physical and environmental challenges, due to changing pressures/volumes and foreign pathogens, respectively. The pulmonary surfactant system is integral in protecting the lung from these challenges via two groups of surfactant proteins – the small molecular weight hydrophobic SPs, SP-B and -C, that regulate interfacial adsorption of the lipids, and the large hydrophilic SPs, SP-A and -D, which are surfa...

  11. Hemorragia alveolar associada a nefrite lúpica Alveolar hemorrhage associated with lupus nephritis

    Directory of Open Access Journals (Sweden)

    Ricardo Henrique de Oliveira Braga Teixeira

    2003-12-01

    Full Text Available Hemorragia alveolar, como causa de insuficiência respiratória, é pouco freqüente, com diversas etiologias possíveis. Entre elas, o lúpus eritematoso sistêmico, que se apresenta geralmente como síndrome pulmão-rim, possui alta morbimortalidade. Acredita-se que a patogênese da microangiopatia, tanto renal como pulmonar, esteja associada ao depósito de imunocomplexos, que ativariam as vias de apoptose celular. Relatam-se dois casos de pacientes com nefrite lúpica que evoluíram com hemorragia alveolar associada à insuficiência respiratória necessitando de ventilação mecânica com evoluções totalmente distintas frente às terapias farmacológicas. O achado de anticorpos antimembrana basal em um dos casos evidencia a multiplicidade de mecanismos fisiopatológicos possivelmente envolvidos, que poderiam justificar as respostas heterogêneas frente aos tratamentos disponíveis.Alveolar hemorrhage leading to respiratory failure is uncommon. Various etiologies have been reported, including systemic lupus erythematosus, which generally presents as pulmonary-renal syndrome. It is believed that the pathogenesis of microangiopathy is related to deposits of immune complexes that lead to activation of cellular apoptosis. The authors report two cases of alveolar hemorrhage and respiratory failure, both requiring mechanical ventilation. The two cases had opposite outcomes after pharmacological therapy. The presence of anti-glomerular basement membrane antibodies in one of the cases demonstrates the multiplicity of physiopathological mechanisms that may be involved. This multiplicity of mechanisms provides a possible explanation for the heterogeneous responses to the available treatments.

  12. CT diagnosis of pulmonary alveolar microlithiasis

    International Nuclear Information System (INIS)

    Purpose: To study the CT findings and evaluate the value of CT in the diagnosis of pulmonary alveolar microlithiasis (PAM). Methods: The CT findings of 9 cases of PAM proved by lung biopsy or clinical diagnosis were retrospectively analysed. Results: On conventional CT, pulmonary window revealed widespread intraalveolar calcifications of both lungs concentrating in the subpleural parenchyma of the middle and lower lobes. The CT value of microliths ranged from 200 to 400 HU, usually combined with pulmonary emphysema and interstitial fibrosis; Mediastinal window showed linear calcifications along pleura or scattered punctate calcifications in the concentrated area of microliths looking like flame or white line in the medial border. On HRCT, pulmonary window revealed diffuse ground-glass appearance, nodules of different sizes, more microliths along the bronchovesicular bundles and thickening of lobule septa. Conclusion: CT, especially HRCT, can better demonstrate pathological features and stage of PAM, playing an important role in diagnosis and differential diagnosis

  13. Computed tomographic appearances of pulmonary alveolar proteinosis

    International Nuclear Information System (INIS)

    We evaluated longitudinal changes in chest CT images in six cases (5 males and one female, age: 35-57 yr) of pulmonary alveolar proteinosis treated with bronchopulmonary lavage. Chest CT images on admission showed a mixed pattern of air-space consolidation and reticular or reticulonodular shadows in most cases and showed a peripheral clear zone in all cases. These shadows gradually diminished after bronchopulmonary lavage. Some cases revealed early improvement in the hilar zone while others had equal improvement in all lung lesions. In one case, consolidation was changed into reticular shadows by treatment. Previous reports have indicated that 'interstitial shadows which disappeared with lavage' reflect edematous thickening of interlobular septa. However, our longitudinal evaluation suggests that interstitial shadows on CT images may reflect not only real interstitial infiltration but also inhomogeneous distribution of intralobular deposits. (author)

  14. Computed tomographic appearances of pulmonary alveolar proteinosis

    Energy Technology Data Exchange (ETDEWEB)

    Takiguchi, Yasuo; Uchiyama, Takashi; Nagao, Keiichi; Kuriyama, Takayuki (Chiba Univ. (Japan). School of Medicine); Fujita, Akira; Hashizume, Ikko

    1994-03-01

    We evaluated longitudinal changes in chest CT images in six cases (5 males and one female, age: 35-57 yr) of pulmonary alveolar proteinosis treated with bronchopulmonary lavage. Chest CT images on admission showed a mixed pattern of air-space consolidation and reticular or reticulonodular shadows in most cases and showed a peripheral clear zone in all cases. These shadows gradually diminished after bronchopulmonary lavage. Some cases revealed early improvement in the hilar zone while others had equal improvement in all lung lesions. In one case, consolidation was changed into reticular shadows by treatment. Previous reports have indicated that 'interstitial shadows which disappeared with lavage' reflect edematous thickening of interlobular septa. However, our longitudinal evaluation suggests that interstitial shadows on CT images may reflect not only real interstitial infiltration but also inhomogeneous distribution of intralobular deposits. (author).

  15. Epidemiology of human alveolar echinococcosis in China.

    Science.gov (United States)

    Craig, Philip S

    2006-01-01

    Globally human alveolar echinococcosis (AE) is a rare zoonotic helminthic disease confined to the Northern Hemisphere as sporadic infections in rural populations, principally in some areas of North America, west-central Europe, the Near East, Siberia, Central Asia, Japan and China. In China the first human cases were reported from western regions in the 1960s, but most hospital records remain fragmented and inadequate. From the mid-1990s mass screening surveys using portable ultrasound scanners recorded higher prevalences (up to 6% by county) than in any other areas of the world with some village rates as high as 15%. Risk factors identified for AE cases included ethnicity, sex, age and occupation. The role of the dog in transmission of Echinococcus multilocularis to humans now appears to be significant and may be one of the most important risk factor, in combination with landscape/land-use features conducive to maintaining wildlife host populations. PMID:16338167

  16. Imaging features of alveolar soft part sarcoma

    Institute of Scientific and Technical Information of China (English)

    Teng Jin; Ping Zhang Co-first author; Xiaoming Li

    2015-01-01

    Objective The aim of this study was to analyze the imaging features of alveolar soft part sarcoma (ASPS). Methods The imaging features of 11 cases with ASPS were retrospectively analyzed. Results ASPS mainly exhibited an isointense or slightly high signal intensity on T1-weighted imaging (T1WI), and a mixed high signal on T2-weighted imaging (T2WI). ASPS was partial, with rich tortuous flow voids, or “line-like” low signal septa. The essence of the mass was heterogeneous enhancement. The 1H-MRS showed a slight choline peak at 3.2 ppm. Conclusion The wel-circumscribed mass and blood voids, combined with “line-like” low signals play a significant role in diagnosis. The choline peak and the other signs may be auxiliary diagnoses.

  17. [Distraction osteogenesis of deficient alveolar bone prior to dental rehabilitation].

    Science.gov (United States)

    Shilo, D; Emodi, O; Aizenbud, D; Rachmiel, A

    2015-07-01

    Implant supported rehabilitation has become very common in treatment plans nowadays, yet many patients lack the vertical and horizontal bone dimensions required for endosseous implant insertion. Distraction osteogenesis is a technique in which bone is generated by progressive elongation of two bone fragments following an osteotomy or corticotomy. Distraction osteogenesis of the alveolar ridge as a treatment modality in implant dentistry is a very useful technique that allows for adequate bone formation suitable for implant insertion. Alveolar distraction can be unidirectional, bidirectional, multidirectional or horizontal. Alveolar distraction osteogenesis can be performed by using intraosseous distraction devices, intraosseous distraction implants or by extraosseous devices which are the most prevalent today. Distraction osteogenesis has many advantages such as gradual lengthening of the bone with no need for an autogenous bone graft and lack of the associated donor site morbidity as well as distraction of the surrounding soft tissue together with the transported bone. One of the major challenges when using alveolar distraction osteogenesis is controlling the vector of distraction, this problem should be further addressed in future researches. We describe different methods for alveolar distraction osteogenesis, including the surgical procedure, latency period, lengthening and consolidation period. We also discuss the advantages, disadvantages and complications of the method. In this manuscript a case of mandibular alveolar deficiency following mandibular fracture and loss of teeth and the alveolar bone is presented. This patient was treated by alveolar distraction osteogenesis with excellent results. This patient was later rehabilitated . using endosseous implants as demonstrated by radiographs. Alveolar distraction osteogenesis provides a method to regain both hard tissue and soft tissue without additional grafting and is an efficient modality in cases of medium

  18. Upper Alveolar Ridge in Edentulous Patients and Caldwell Luc Surgery

    OpenAIRE

    Ashok Murthy, V.; Mahendra Kumar, R.

    2012-01-01

    The aim of this study is to understand the upper alveolar ridge changes and its impact on Caldwell Luc surgery, in a patient papulation from a Medical College Hospital. We undertook a study to measure the thickness of upper alveolar ridge in edentulous and edentulous patients, to know the difference between the two and its effects on Caldwell Luc surgery. The finding of the study led us to conclude that the upper alveolar ridge is quite thin in edentulous patients and requires care while scra...

  19. Crazy paving radiography finding in asymptomatic pulmonary alveolar proteinosis.

    Science.gov (United States)

    Choi, Young Rak; Chang, You-Jin; Kim, Si Wook; Choe, Kang Hyeon; Lee, Ki Man; An, Jin-Young

    2015-06-01

    Pulmonary alveolar proteinosis is a rare disorder characterized by alveolar accumulation of surfactant phospholipids and protein components. The symptoms and prognosis are extremely variable. Bronchoalveolar lavage fluid and/or transbronchial lung biopsy are useful for diagnosis; surgical lung biopsy is often unnecessary but useful in the focal involvement. We report a case of pulmonary alveolar proteinosis in a 50-year-old woman, confirmed by a video-assisted thoracoscopic surgery biopsy from the initial focal involvement, with normal bronchoalveolar lavage and transbronchial lung biopsy findings. PMID:25182335

  20. Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice

    OpenAIRE

    Bem, R. A.; Farnand, A. W.; Wong, V; Koski, A; Rosenfeld, M. E.; Van Rooijen, N.; C. W. Frevert; Martin, T R; Matute-Bello, G.

    2008-01-01

    Activation of the Fas/Fas ligand (FasL) system in the lungs results in a form of injury characterized by alveolar epithelial apoptosis and neutrophilic inflammation. Studies in vitro show that Fas activation induces apoptosis in alveolar epithelial cells and cytokine production in alveolar macrophages. The main goal of this study was to determine the contribution of alveolar macrophages to Fas-induced lung inflammation in mice, by depleting alveolar macrophages using clodronate-containing lip...

  1. CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia

    OpenAIRE

    Li, Xiaopeng; Comellas, Alejandro P.; Karp, Philip H.; Ernst, Sarah E.; Moninger, Thomas O.; Gansemer, Nicholas D.; Taft, Peter J.; Pezzulo, Alejandro A; Michael V Rector; Rossen, Nathan; Stoltz, David A.; McCray, Paul B.; Welsh, Michael J.; Zabner, Joseph

    2012-01-01

    A balance between alveolar liquid absorption and secretion is critical for maintaining optimal alveolar subphase liquid height and facilitating gas exchange in the alveolar space. However, the role of cystic fibrosis transmembrane regulator protein (CFTR) in this homeostatic process has remained elusive. Using a newly developed porcine model of cystic fibrosis, in which CFTR is absent, we investigated ion transport properties and alveolar liquid transport in isolated type II alveolar epitheli...

  2. Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report

    OpenAIRE

    Sawai, Toyomitsu; Umeyama, Yasuhiro; Yoshioka, Sumako; Matsuo, Nobuko; Suyama, Naofumi; Kohno, Shigeru

    2014-01-01

    Introduction Pulmonary alveolar proteinosis is a rare pulmonary disease characterized by excessive alveolar accumulation of surfactant due to defective alveolar clearance by macrophages. There are only a few published case reports of pulmonary alveolar proteinosis occurring in association with solid cancers. To the best of our knowledge, there are no previously reported cases of pulmonary alveolar proteinosis associated with breast cancer. Case presentation A 48-year-old Asian woman, a nonsmo...

  3. The role of synthetic biomaterials in resorptive alveolar bone regeneration

    Directory of Open Access Journals (Sweden)

    Kaličanin Biljana M.

    2007-01-01

    Full Text Available The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.

  4. Alveolar proteinosis lung lavage using partial cardiopulmonary bypass.

    OpenAIRE

    Freedman, A P; Pelias, A; Johnston, R F; Goel, I P; Hakki, H I; Oslick, T; Shinnick, J P

    1981-01-01

    An adult case of pulmonary alveolar proteinosis presented with an arterial oxygen tension of 27 mmHg (3.6 kPa) while breathing air. Dangerous hypoxaemia during lung lavage was avoided by using partial cardiopulmonary bypass.

  5. Pulmonary Alveolar Proteinosis: A Rare Cause of Respiratory Failure.

    Science.gov (United States)

    Munir, Zeeshan; Khosa, Muhammad Zeeshan; Qazi, Muhammad Yaqoob

    2015-07-01

    Pulmonary Alveolar Proteinosis (PAP) is a rare syndrome in the paediatric age group and characterized by intra-alveolar accumulation of proteinaceous phospholipid-laden material called surfactant. The diagnosis is made by High Resolution Computed Tomography (HRCT) chest which shows characteristic crazy paving appearance and diagnosis confirmed by Bronchoalveolar Lavage (BAL). We report two cases. First was a 9-month old infant who presented with respiratory distress and peripheral cyanosis since birth. He was diagnosed on High Resolution Computed Tomography (HRCT) chest as a case of pulmonary alveolar proteinosis and broncho-alveolar lavage confirmed his diagnosis. Second case was a 10-year old female child who had a history of repeated chest infections for 5 years and now presented with cough and respiratory distress for 45 days. She was also diagnosed on HRCT chest but unfortunately she died before bronchoalveolar lavage. PMID:26208564

  6. Alveolar proteinosis in Behçet's disease

    Directory of Open Access Journals (Sweden)

    Tetikkurt Cuneyt

    2010-08-01

    Full Text Available Abstract A 51-year-old man with Behçet's disease complained of fever, dry cough and dyspnea during exertion. Chest CT showed ground glass opacities with interstitial septal thickening in both lungs. Bronchoalveolar lavage (BAL revealed amorphous and lipoproteinaceous material that was periodic acid-Schiff (PAS stain positive. Transbronchial biopsy specimen demonstrated PAS positive alveolar eosinophilic material consistent with pulmonary alveolar proteinosis. Serum anti-granulocyte-macrophage colony stimulating factor (GM-CSF antibody was negative. Recent studies have reported anti-GMCSF not present in the the serum of patients with secondary pulmonary alveolar proteinosis (PAP but they have not reported so in patients with idiopathic PAP. We report a case of alveolar proteinosis in the setting of Behçet's disease with spontaneous remission.

  7. Alveolar lymphangioma in infants: report of two cases.

    LENUS (Irish Health Repository)

    FitzGerald, Kirsten

    2009-06-01

    The alveolar lymphangioma is a benign but relatively rare condition found only in the oral cavities of black infants. Dentists practising in Ireland may be unaware of this condition due to its racial specificity. This paper presents two case reports of multiple alveolar lymphangiomas found in black infants in a children\\'s hospital in Ireland. The epidemiology, aetiology, clinical presentation, histology, and management options are discussed. The photographs should aid the practitioner in recognising these lesions.

  8. Dynamics of surfactant release in alveolar type II cells

    OpenAIRE

    Haller, Thomas; Ortmayr, Jörg; Friedrich, Franz; Völkl, Harald; Dietl, Paul

    1998-01-01

    Pulmonary surfactant, secreted via exocytosis of lamellar bodies (LB) by alveolar type II (AT II) cells, maintains low alveolar surface tension and is therefore essential for normal lung function. Here we describe real-time monitoring of exocytotic activity in these cells by visualizing and quantifying LB fusion with the plasma membrane (PM). Two approaches were used. First, fluorescence of LysoTracker Green DND-26 (LTG) in LB disappeared when the dye was released after exocytosis. Second, ph...

  9. Identification of a cell membrane protein that binds alveolar surfactant.

    OpenAIRE

    Strayer, D. S.

    1991-01-01

    Alveolar surfactants are complex mixtures of proteins and phospholipids produced by type II alveolar cells and responsible for lowering pulmonary surface tension. The process by which surfactant is produced and exported and by which its production by pulmonary cells is regulated are not well understood. This study was designed to identify a cellular receptor for surfactant constituents. To do so, monoclonal anti-idiotypic antibodies directed against antibodies to porcine and rabbit surfactant...

  10. Is alveolar cleft reconstruction still controversial? (Review of literature)

    OpenAIRE

    Seifeldin, Sameh A.

    2015-01-01

    Cleft lip and palate (CL/P) is a frequent congenital malformation that manifests in several varieties including unilateral or bilateral and complete or incomplete. Alveolar cleft reconstruction remains controversial with regard to timing, graft materials, surgical techniques, and methods of evaluation. Many studies have been conducted addressing these points to develop an acceptable universal protocol for managing CL/P. The primary goal of alveolar cleft reconstruction in CL/P patients is to ...

  11. Familial occurrence of pulmonary alveolar microlithiasis in 3-siblings

    International Nuclear Information System (INIS)

    Pulmonary alveolar microlithiasis (PAM) is a rare disease of unknown etiology characterized by intra-alveolar calcium deposits. More than 500 cases were reported in the literature. The disorder affects people at every age beginning from the early childhood. It occurs probably as a result of autosomal recessive transmission. Familial occurrence is often found with family history of the disease being present in up to 50% of the reported cases. We report PAM in 3 siblings. (author)

  12. Alveolar lymphangioma in infants: report of two cases.

    LENUS (Irish Health Repository)

    FitzGerald, Kirsten

    2012-02-01

    The alveolar lymphangioma is a benign but relatively rare condition found only in the oral cavities of black infants. Dentists practising in Ireland may be unaware of this condition due to its racial specificity. This paper presents two case reports of multiple alveolar lymphangiomas found in black infants in a children\\'s hospital in Ireland. The epidemiology, aetiology, clinical presentation, histology, and management options are discussed. The photographs should aid the practitioner in recognising these lesions.

  13. Alveolar proteinosis in Behçet's disease

    OpenAIRE

    Tetikkurt Cuneyt; Tetikkurt Seza; Ozdemir Imran; Zuhur Cigdem; Bayar Nihal

    2010-01-01

    Abstract A 51-year-old man with Behçet's disease complained of fever, dry cough and dyspnea during exertion. Chest CT showed ground glass opacities with interstitial septal thickening in both lungs. Bronchoalveolar lavage (BAL) revealed amorphous and lipoproteinaceous material that was periodic acid-Schiff (PAS) stain positive. Transbronchial biopsy specimen demonstrated PAS positive alveolar eosinophilic material consistent with pulmonary alveolar proteinosis. Serum anti-granulocyte-macropha...

  14. Anaesthetic management of bilateral alveolar proteinosis for bronchopulmonary lavage.

    Directory of Open Access Journals (Sweden)

    Dixit R

    1998-01-01

    Full Text Available The most hazardous manifestation of pulmonary alveolar proteinosis is progressive hypoxia for which bronchopulmonary lavage (BPL is the single most effective treatment. Unfortunately this procedure under general anesthesia itself increases the risk of hypoxia due to the need for one lung ventilation. It was therefore considered interesting to report the successful anaesthetic management of a patient with pulmonary alveolar proteinosis for Bronchopulmonary lavage.

  15. Alveolar proteinosis and nocardiosis: a patient treated by bronchopulmonary lavage.

    OpenAIRE

    Pascual, J.; Gómez Aguinaga, M. A.; Vidal, R; Maudes, A.; Sureda, A.; Gómez Mampaso, E.; Fogué, L.

    1989-01-01

    Alveolar proteinosis is a relatively rare disease of unclear pathogenesis associated with opportunistic-infections. Although nocardiosis is the most frequent one, only 22 cases have been reported previously and are reviewed here. We present a patient with alveolar proteinosis with nocardiosis treated as an emergency with bilateral bronchopulmonary lavage and antibiotics. No previous cases of this association have been successfully managed in this way.

  16. Alveolar ridge augmentation by osteoinductive materials in goats

    DEFF Research Database (Denmark)

    Pinholt, E M; Haanaes, H R; Roervik, M;

    1992-01-01

    The purpose of the present study was to determine whether alveolar ridge augmentation could be induced in goats. In 12 male goats allogenic, demineralized, and lyophilized dentin or bone was implanted subperiosteally on the buccal sides of the natural edentulous regions of the alveolar process of...... of the mandible. Light microscopic evaluation revealed fibrous encapsulation, a few multinuclear giant cells, little inflammatory reaction, and no osteoinduction. It was concluded that no osteoinduction took place in goats....

  17. Spontaneous monokine release by alveolar macrophages in chronic sarcoidosis

    OpenAIRE

    Strausz, J; Männel, Daniela N.; S. Pfeifer; A. Borkowski; Ferlinz, R.; Müller-Quernheim, J.

    1991-01-01

    In pulmonary sarcoidosis an activation of alveolar T lymphocytes and alveolar macrophages (AM) has been demonstrated. There is evidence that in contrast to acute disease a heightened T-cell response cannot be observed in the chronic phase of sarcoidosis. The role of AM in the inflammatory process of chronic sarcoidosis is not yet intensively evaluated. To address this question we measured the release of tumor necrosis factor alpha (TNF alpha) and interleukin-1 (IL-1) by AM of 39 patients with...

  18. Thermodynamic analysis of thermosolar plants; Analisis termodinamico de plantas termosolares

    Energy Technology Data Exchange (ETDEWEB)

    Munoz, Felipe; Rojas, Armando [UNAM, Mexico, D.F. (Mexico)

    2000-07-01

    In this work we obtained the mathematical expressions to calculate the concentration area for parabolic trough and central tower solar systems in thermosolar plants. Thermodynamic analysis considering 1{sup s}t and 2{sup n}d laws were made for gas and steam energy conversion cycles joined to thermosolar plants. Economical analysis were made too. In this way, higher thermal efficiencies 57.4, 58, 57 y 58.1% and 2{sup n}d law efficiencies 76.6, 77.5, 76, y 77.6% were found with combined cycle and central tower solar system. However, the cheaper configuration (773.5 USD/MWh), found by the economic analysis, was the parabolic trough solar system with steam cycle. [Spanish] En este trabajo se determinan las expresiones matematicas para obtener el area de concentracion requerida en plantas termosolares de canal parabolico y de torre central combinadas con ciclos de generacion convencionales. Se realiza el analisis termodinamico con base en la primera y segunda ley a cada ciclo y asi mismo se efectua el analisis economico de dichos arreglos. Se encuentra que las mayores eficiencias termicas 57.4, 58, 57 y 58.1% y las eficiencias de 2 ley: 76.6, 77.5, 76, y 77.6% se tienen con sistema de torre central y ciclo combinado. El analisis economico expresa que el sistema solar con concentradores de canal parabolico con ciclos de vapor presenta el menor costo total de generacion (773.5 USD/MWh).

  19. Horizontal alveolar bone loss: A periodontal orphan

    Directory of Open Access Journals (Sweden)

    Jayakumar A

    2010-01-01

    Full Text Available Background: Attempts to successfully regenerate lost alveolar bone have always been a clinician′s dream. Angular defects, at least, have a fairer chance, but the same cannot be said about horizontal bone loss. The purpose of the present study was to evaluate the prevalence of horizontal alveolar bone loss and vertical bone defects in periodontal patients; and later, to correlate it with the treatment modalities available in the literature for horizontal and vertical bone defects. Materials and Methods: The study was conducted in two parts. Part I was the radiographic evaluation of 150 orthopantomographs (OPGs (of patients diagnosed with chronic periodontitis and seeking periodontal care, which were digitized and read using the AutoCAD 2006 software. All the periodontitis-affected teeth were categorized as teeth with vertical defects (if the defect angle was ≤45° and defect depth was ≥3 mm or as having horizontal bone loss. Part II of the study comprised search of the literature on treatment modalities for horizontal and vertical bone loss in four selected periodontal journals. Results: Out of the 150 OPGs studied, 54 (36% OPGs showed one or more vertical defects. Totally, 3,371 teeth were studied, out of which horizontal bone loss was found in 3,107 (92.2% teeth, and vertical defects were found only in 264 (7.8% of the teeth, which was statistically significant (P<.001. Search of the selected journals revealed 477 papers have addressed the treatment modalities for vertical and horizontal types of bone loss specifically. Out of the 477 papers, 461 (96.3% have addressed vertical bone loss, and 18 (3.7% have addressed treatment options for horizontal bone loss. Two papers have addressed both types of bone loss and are included in both categories. Conclusion: Horizontal bone loss is more prevalent than vertical bone loss but has been sidelined by researchers as very few papers have been published on the subject of regenerative treatment

  20. Intorno all'analisi sintattica della frase semplice in italiano /

    Directory of Open Access Journals (Sweden)

    Josip Jernej

    2004-12-01

    Full Text Available Secondo una lunga tradizione confermata anche da opere illustri come la Sin­ tassi italiana di Raffaello Fornaciari del 1881, gli autori delle grammatiche italiane, nel trattare la struttura della frase semplice, adottano una soluzione fortemente influenzata dalla semantica, con i cosiddetti complementi indiretti. Trattasi di un modello che si differenzia completamente da quello adottato nelle grammatiche delle altre grandi lingue europee, come i1francese, il tedesco, il russo, in cui l'analisi della frase semplice è impostata  su criteri  essenzialmente sintattici.

  1. Experimental radiation pneumonitis: changes in physiology of the alveolar surface

    International Nuclear Information System (INIS)

    Mice received 2400 rads in two fractions to the thorax; 4 months later at a time when deaths began, mechanical and biochemical properties of the lungs were studied and compared to those of littermate controls. The principal mechanical change was a large increase in the elastance of the alveolar surface element and abnormal surface tension properties of the AF. Alveolar fluid phospholipid content and saturation were only minimally changed; however the alveolar fluid contained a large excess of protein, possible of circulatory origin. The latter may explain the fall in compliance of the alveolar surface and hence of the lung in radiation pneumoritis. A small increase in elastance of the lung tissue element was also found; this correlated with a decrease in lung volume and a small increase in lung hydroxyproline content. These changes may signify the early development of radiation fibrosis. Other features of this model are the frequent occurrence of pleural effusions and the presence of increased numbers of alveolar macrophages in the alveolar lavage

  2. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

    Science.gov (United States)

    Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F.; An, Gary

    2013-06-01

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  3. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

    International Nuclear Information System (INIS)

    Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the

  4. Cardiovascular risk in pulmonary alveolar proteinosis.

    Science.gov (United States)

    Manali, Effrosyni D; Papadaki, Georgia; Konstantonis, Dimitrios; Tsangaris, Iraklis; Papaioannou, Andriana I; Kolilekas, Likurgos; Schams, Andrea; Kagouridis, Konstantinos; Karakatsani, Anna; Orfanos, Stylianos; Griese, Matthias; Papiris, Spyros A

    2016-02-01

    We hypothesized that cardiovascular events and/or indices of cardiac dysfunction may be increased in pulmonary alveolar proteinosis (PAP). Systemic and pulmonary arterial hypertension, arrhythmias, pulmonary embolism, stroke and ischemic heart attack were reported. Patients underwent serum anti-GM-CSF antibodies, disease severity score (DSS), Doppler transthoracic echocardiograph, glucose, thyroid hormones, lipids, troponin and pro-Brain natriuretic peptide (BNP) examination. Thirteen patients (8 female) were studied, median age of 47. Pro-BNP inversely related to DLCO% and TLC%; troponin directly related to DSS, age, P(A-a)O2, left atrium-, left ventricle-end-diastole diameter and BMI. On multiple regression analysis DSS was the only parameter significantly and strongly related with troponin (R(2) = 0.776, p = 0.007). No cardiovascular event was reported during follow-up. In PAP cardiovascular risk indices relate to lung disease severity. Therefore, PAP patients could be at increased risk for cardiovascular events. Quantitation of its magnitude and potential links to lungs' physiologic derangement will be addressed in future studies. PMID:26558331

  5. Analisis SWOT Pada Warung Bang Man Di Kawasan Waruug Kopi (Warkop) Harapan Medan

    OpenAIRE

    Ricka Alamia Z

    2008-01-01

    Ricka Alamia Z, 2006. Analisis SWOT Pada Warnng Bang Man di Kawasan Warung Kopi (Warkop) Harapan Medan. Di bawah bimbingan Dra. Marhaini, MS, Ibu Prof. Dr. Ritha F Dalimunthe, SE, MSi (Ketua Departemen Manajemen), ibu Frida Ramadini, SE, MM (Penguji I), Ibu Dra, Lisa Marlina, MSi (Penguji II). Penelitian ini bertujuan untuk menganalisis SWOT yang ada pada Warung Bang Man. Analisis SWOT merupakan penilaian lingkungan internal berupa kekuatan (strength) dan kelemahan (weakness) serta lingkungan...

  6. ANALISIS KOMPARATIF STATIK TERHADAP PERMINTAAN KREDIT PADA BANK SYARIAH DAN BANK KONVENSIONAL DI KOTA MAKASSAR

    OpenAIRE

    Hamzah, Anggriawan Pradana

    2012-01-01

    Permasalahan dalam penelitian ini adalah apakah PDRB, bagi hasil dan laju inflasi berpengaruh terhadap permintaan kredit pada Bank Syariah serta PDRB, suku bunga dan laju inflasi berpengaruh terhadap permintaan kredit pada Bank Konvensional, serta apakah ada perbedaan antara permintaan kredit Bank Syariah dengan Bank Konvensional. Untuk menjawab permasalahan tersebut maka digunakan metode analisis regresi linear sederhana. Hasil analisis yang dilakukan menunjukkan bahwa pengaruh PDRB terha...

  7. Unsur-unsur Humanisme dalam Novel Tabula Rasa Karya Ratih Kumala : Analisis Psikologi Sastra

    OpenAIRE

    Tarigan, Itana

    2011-01-01

    Penelitian ini berjudul Unsur-unsur Humanisme dalam Novel Tabula Rasa Karya Ratih Kumala : Analisis Psikologi Sastra. Penelitian ini bertujuan untuk mengetahui unsur-unsur humanisme. Untuk mencapai tujuan tersebut maka data dikumpulkan dari novel yang berjudul yang berjudul Tabula rasa dengan menggunakan metode membaca heuristik dan hermeneutik. Data yang digunakan yaitu data primer dan data sekunder. Data primer diambil dari bahan analisis yaitu novel Tabula Rasa dan data sekunder diambil ...

  8. Effects of smoking on edentulous alveolar ridge mucosa

    Directory of Open Access Journals (Sweden)

    Marković Dubravka

    2005-01-01

    Full Text Available Introduction Tobacco use is an important risk factor for advanced histopathological findings on edentulous alveolar ridge mucosa. The aim of this study was to examine the effects of smoking on histopathological findings on edentulous alveolar ridge mucosa. Material and methods The experimental group consisted of 48 patients (29 smokers and 19 nonsmokers. The mean age of smokers was 42.6 and of nonsmokers 48.7 years. The anamnesis included the following data: age, sex, diseases and toxic habits-cigarette smoking. Biopsy samples were taken from the edentulous alveolar ridge mucosa without gross signs of symptoms. Results The mean number of cigarettes smoked per day was 11.5±7. The results of χ² test proved that there were no statistically significant differences (p>0.05 in histopathological findings on the alveolar ridge mucosa. The mean duration of smoking was 12.7± 5 years. Hyperkeratosis was established in 76.92% of smokers who smoked longer than 15 years. The mean-age at which smokers began smoking was 27.3±8 years and there were no statistically significant differences in histopathological findings on the alveolar ridge mucosa correlated with the beginning of smoking. Conclusion On the basis of our research we conclude that smokers who have been smoking for 15 years are at risk for developing histopathological changes of the alveolar ridge mucosa, but there were no statistically significant differences in histopathological findings on the alveolar ridge mucosa correlated with the number of cigarettes per day and the beginning of smoking. .

  9. Partial pulmonary embolization disrupts alveolarization in fetal sheep

    Directory of Open Access Journals (Sweden)

    Hooper Stuart B

    2010-04-01

    Full Text Available Abstract Background Although bronchopulmonary dysplasia is closely associated with an arrest of alveolar development and pulmonary capillary dysplasia, it is unknown whether these two features are causally related. To investigate the relationship between pulmonary capillaries and alveolar formation, we partially embolized the pulmonary capillary bed. Methods Partial pulmonary embolization (PPE was induced in chronically catheterized fetal sheep by injection of microspheres into the left pulmonary artery for 1 day (1d PPE; 115d gestational age; GA or 5 days (5d PPE; 110-115d GA. Control fetuses received vehicle injections. Lung morphology, secondary septal crests, elastin, collagen, myofibroblast, PECAM1 and HIF1α abundance and localization were determined histologically. VEGF-A, Flk-1, PDGF-A and PDGF-Rα mRNA levels were measured using real-time PCR. Results At 130d GA (term ~147d, in embolized regions of the lung the percentage of lung occupied by tissue was increased from 29 ± 1% in controls to 35 ± 1% in 1d PPE and 44 ± 1% in 5d PPE fetuses (p VEGF and Flk-1, although a small increase in PDGF-Rα expression at 116d GA, from 1.00 ± 0.12 in control fetuses to 1.61 ± 0.18 in 5d PPE fetuses may account for impaired differentiation of alveolar myofibroblasts and alveolar development. Conclusions PPE impairs alveolarization without adverse systemic effects and is a novel model for investigating the role of pulmonary capillaries and alveolar myofibroblasts in alveolar formation.

  10. Proteinose alveolar pulmonar: série de quatro casos Pulmonary alveolar proteinosis: four cases

    Directory of Open Access Journals (Sweden)

    João Carlos Thompson

    2006-06-01

    Full Text Available OBJETIVO: Apresentar a evolução de quatro casos de proteinose alveolar pulmonar atendidos na Faculdade de Medicina da Universidade Estadual de Londrina, enfocando a importância da lavagem pulmonar total como tratamento de escolha. MÉTODOS: Trata-se de um estudo retrospectivo de quatro pacientes, sendo três do gênero feminino, com idades de 22 a 34 anos, e histórias semelhantes de dispnéia progressiva e tosse seca. O diagnóstico final foi realizado por biópsia pulmonar a céu aberto. A lavagem pulmonar total foi realizada em três pacientes em centro cirúrgico, com anestesia geral e sonda de duplo lúme. RESULTADOS: Um paciente apresentou regressão espontânea da proteinose alveolar pulmonar, não sendo necessária a lavagem pulmonar. Nos outros três casos, o número de lavagens variou: uma única lavagem unilateral com remissão completa do quadro bilateralmente, três lavagens sem melhora significativa e quatro procedimentos intercalados com períodos de melhora. CONCLUSÃO: Constatamos em nossa casuística que a lavagem pulmonar se mostrou eficiente, apesar de alguns pacientes apresentarem certa resistência ao procedimento, enquanto que outros podem ter remissão completa da doença.OBJECTIVE: The aim of this study was to present the evolution of four patients presenting pulmonary alveolar proteinosis and treated at the State University of Londrina School of Medicine. We focus on the importance of whole-lung lavage as the treatment of choice. METHODS: A retrospective study of four patients, three females and one male, 22 to 34 years old, presenting similar histories of progressive dyspnea and dry cough. The final diagnosis was established through open-lung biopsy. Three of the patients underwent whole-lung lavage in the Department of Surgery. The procedures were performed under general anesthesia and using a double-lumen endotracheal tube. RESULTS: One patient presented spontaneous regression of the pulmonary alveolar proteinosis

  11. Degradation of pulmonary surfactant disaturated phosphatidylcholines by alveolar macrophages

    International Nuclear Information System (INIS)

    Experiments were performed to determine whether rat pulmonary surfactant disaturated phosphatidylcholines (DSPC) are degraded by alveolar macrophages in vitro. When [3H]choline-labeled surfactant materials are incubated with unlabeled alveolar macrophages, approximately 40% of the labeled DSPC is broken down in 6 h. There is just a slight decrease in the specific activity of DSPC, which suggests that most products of degradation are not reincorporated into DSPC, at least during the 6-h incubation period. There is a time- and temperature-dependent association of surfactant DSPC with alveolar macrophages, and some of the cell-associated materials are released from the cell fragments after sonication. Association of surfactant with the cells precedes degradation. The breakdown of surfactant DSPC by intact alveolar macrophages lags behind that produced by sonicated cell preparations with disrupted cell membranes. These data and other information suggest that the surfactant materials are internalized by the cells, before the breakdown. The products of degradation probably include free choline and fatty acids, most of which appear in the extracellular fluid. The breakdown processes do not seem to depend on the physical form of the surfactant or on the presence of surfactant apoproteins. Incubation of the cells alone also results in disappearance of intracellular DSPC, some of which may be surfactant phospholipid taken up by the cells in vivo. These results indicate that alveolar macrophages can degrade surfactant DSPC and suggest that these cells may be involved in catabolism of pulmonary surfactant materials

  12. The effect of exogenous surfactant on alveolar interdependence.

    Science.gov (United States)

    Salito, Caterina; Aliverti, Andrea; Mazzuca, Enrico; Rivolta, Ilaria; Miserocchi, Giuseppe

    2015-05-01

    To investigate the nature of alveolar mechanical interdependence, we purposefully disturbed the equilibrium condition by administering exogenous surfactant in physiological non-surfactant deprived conditions. Changes in alveolar morphology induced by intra-tracheal delivery of CUROSURF were evaluated after opening a pleural window allowing in-vivo microscopic imaging of sub-pleural alveoli in 6 male anesthetized, tracheotomized and mechanically ventilated rabbits. Surfactant instillation increased the surface area of alveoli smaller than 20,000 μm(2) up to ∼ 50% at 15 min after instillation, reflecting a lowering of surface tension due to local surfactant enrichment. Conversely, for alveoli greater than 20,000 μm(2), surface area decreased by ∼ 5%. Opposite changes in alveolar surface are interpreted as reflecting a new inter-alveolar mechanical equilibrium modified by local surfactant distribution and by a decrease in lung distending pressure. We propose that smaller alveoli, representing the majority of alveolar population, might mostly contribute to improve the oxygenation index following surfactant replacement therapy in case of surfactant deficiency. PMID:25600053

  13. Is alveolar cleft reconstruction still controversial? (Review of literature

    Directory of Open Access Journals (Sweden)

    Sameh A. Seifeldin

    2016-01-01

    Full Text Available Cleft lip and palate (CL/P is a frequent congenital malformation that manifests in several varieties including unilateral or bilateral and complete or incomplete. Alveolar cleft reconstruction remains controversial with regard to timing, graft materials, surgical techniques, and methods of evaluation. Many studies have been conducted addressing these points to develop an acceptable universal protocol for managing CL/P. The primary goal of alveolar cleft reconstruction in CL/P patients is to provide a bony bridge at the cleft site that allows maxillary arch continuity, oronasal fistula repair, eruption of the permanent dentition into the newly formed bone, enhances nasal symmetry through providing alar base support, orthodontic movement and placement of osseointegrated implants when indicated. Other goals include improving speech, improvement of periodontal conditions, establishing better oral hygiene, and limiting growth disturbances. In order to rehabilitate oral function in CL/P patients alveolar bone grafting is necessary. Secondary bone grafting is the most widely accepted method for treating alveolar clefts. Autogenous bone graft is the primary source for reconstructing alveolar cleft defects and is currently the preferred grafting material.

  14. Alveolar rhabdomyosarcoma involving the mandibular ramus and its surrounding tissues

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Suk Ja; Kang, Byung Cheol [Chonnam National University College of Medicine, Gwangju (Korea, Republic of)

    2004-06-15

    Rhabdomyosarcoma, when it occurs in the head and neck, is primarily found in children. Alveolar rhabdomyosarcoma is rarely seen in the oral lesion, comparing to the embryonal and the pleomorphic variants. This is a report of a case of alveolar rhabdomyosarcoma in the mandible in a ten-year old girl who complained of a non-painful swelling on the right cheek. The right lower 1st molar was mobile. Her radiographs revealed an extensive radiolucency with somewhat irregular border on the right mandibular ramus. The right mandibular 1st and 2nd molars lost their lamina dura and were floating. CT images revealed smooth-outlined soft tissue mass occupying the pterygomandibular space, the infratemporal space, and the masseteric muscle with thinning and perforation of the right mandibular angle and ramus. Histopathological and immunohistochemical findings established the final diagnosis of alveolar rhabdomyosarcoma.

  15. Traumatic neuroma of the inferior alveolar nerve: a case report.

    Science.gov (United States)

    Arribas-García, Ignacio; Alcalá-Galiano, Andrea; Gutiérrez, Ramón; Montalvo-Moreno, Juan José

    2008-03-01

    Traumatic neuromas are rare entities which characteristically arise subsequently to surgery and are usually accompanied by pain, typically neuralgic. We present an unusual case of an intraosseous traumatic neuroma of the inferior alveolar nerve following tooth extraction. A 56-year-old man consulted for paresthesias and hyperesthesia in the left mandibular region following extraction of the left mandibular third molar (#38). The panoramic radiograph revealed a radiolucent lesion in the inferior alveolar nerve canal, and CT demonstrated the existence of a mass within the canal, producing widening of the same. Nerve-sparing excisional biopsy was performed. Histopathology and immunohistochemistry were consistent with traumatic neuroma of the left inferior alveolar nerve. After 3 years of follow-up, the patient is asymptomatic and there are no signs of recurrence.

  16. Acute pulmonary alveolar proteinosis due to exposure to cotton dust

    Directory of Open Access Journals (Sweden)

    Thind Gurcharan

    2009-01-01

    Full Text Available Secondary pulmonary alveolar proteinosis (PAP is rare but may occur in association with malignancy, certain infections, and exposure to inorganic or organic dust and some toxic fumes. This case report describes the second recorded case of PAP due to exposure to cotton dust. A 24-year-old man developed PAP after working as a spinner for eight years without respiratory protection. He was admitted as an emergency patient with very severe dyspnea for four months and cough for several years. Chest X-ray showed bilateral diffuse alveolar consolidation. He died 16 days later, and a diagnosis of acute pulmonary alveolar proteinosis was made at autopsy. The histopathology demonstrated alveoli and respiratory bronchioles filled with characteristic periodic acid Schiff-positive material, which also revealed birefringent bodies of cotton dust under polarized light. Secondary PAP can be fatal and present with acute respiratory failure. The occupational history and characteristic pathology can alert clinicians to the diagnosis.

  17. Rare combination of congenital heart disease and pulmonary alveolar proteinosis.

    Science.gov (United States)

    Tanaka, Yuki; Miyamoto, Takashi; Yoshitake, Shuichi; Naito, Yuji; Kobayashi, Tomio

    2015-10-01

    Here, we describe a case of total anomalous pulmonary venous return with coarctation of the aorta that was diagnosed as pulmonary alveolar proteinosis at autopsy in a male infant. Surgical repair was performed at 1 day of age, but the infant died on postoperative day 51 due to respiratory insufficiency without any evidence of pulmonary venous obstruction. He had been unexpectedly diagnosed with pulmonary alveolar proteinosis and pulmonary hypoplasia on autopsy. Congenital pulmonary alveolar proteinosis is a serious condition with a high mortality rate, which should be considered in the differential diagnosis in patients with a clinical picture of pulmonary venous obstruction, because most patients are unable to survive without proper treatment. In this report, we address specific issues that should be discussed in such cases based on our recent experience. PMID:26310609

  18. Variant Inferior Alveolar Nerves and Implications for Local Anesthesia.

    Science.gov (United States)

    Wolf, Kevin T; Brokaw, Everett J; Bell, Andrea; Joy, Anita

    2016-01-01

    A sound knowledge of anatomical variations that could be encountered during surgical procedures is helpful in avoiding surgical complications. The current article details anomalous morphology of inferior alveolar nerves encountered during routine dissection of the craniofacial region in the Gross Anatomy laboratory. We also report variations of the lingual nerves, associated with the inferior alveolar nerves. The variations were documented and a thorough review of literature was carried out. We focus on the variations themselves, and the clinical implications that these variations present. Thorough understanding of variant anatomy of the lingual and inferior alveolar nerves may determine the success of procedural anesthesia, the etiology of pathologic processes, and the avoidance of surgical misadventure. PMID:27269666

  19. ANALISIS RELEVANSI LULUSAN PERGURUAN TINGGI DENGAN DUNIA KERJA

    Directory of Open Access Journals (Sweden)

    Ali Muhson

    2012-04-01

    Full Text Available Abstract: A Relevance Analysis of University Graduates with World of Work. Education should be oriented to the competencies required by the workforce as a percentage of unemployment among the educated increase continuously. This study aims to examine the relevance of YSU Economic Education graduates. The study only focuses on the type of work and subjects taught. The subject of this study is the alumni of Economic Education Study Program. Sampling technique used is snowball sampling. Data collection technique using questionnaires and documentation while the technique of data analysis using descriptive analysis. The result suggests that the majority of the graduates find their first job as private a teacher, a private employee and a tutor, while current job of the most graduates are private teacher, private employee, and civil servant (teacher. The data shows that more than 50 percent of the graduates work in the education area. This implies that the relevance level based on the type of work is categorized as sufficient. Majority of the graduates teaches social science, economic, and entrepreneurship, hence it can be concluded that the relevance level based on the subjects taught is highly relevant.   Keyword: relevance of graduates, type of work, unemployment, employment     Abstrak: Analisis Relevansi Lulusan Perguruan Tinggi dengan Dunia Kerja. Pendidikan harus berorientasi pada kompetensi yang dibutuhkan oleh dunia kerja karena persentase penganggur di kalangan terdidik terus meningkat. Penelitian ini bertujuan untuk mengkaji tingkat relevansi (kesesuaian lulusan Pendidikan Ekonomi UNY. Kajian hanya diarahkan pada jenis pekerjaan dan mata pelajaran yang diampu. Penelitian ini mengambil subjek alumni Prodi Pendidikan Ekonomi dari berbagai angkatan. Teknik sampling yang digunakan adalah snowball sampling. Teknik pengumpulan data menggunakan angket dan dokumentasi sedangkan teknik analisis data menggunakan analisis deskriptif. Penelitian ini

  20. ANALISIS SPASIAL FAKTOR LINGKUNGAN DAN KEJADIAN DBD DI KABUPATEN DEMAK

    Directory of Open Access Journals (Sweden)

    Musyarifatun Farahiyah

    2014-05-01

    Full Text Available AbstractDengue Haemoragic Fever (DHF was still a public health problem in Demak District, Central Java. In the year of 2012, there were 483 DHF cases and 6 of them were died. Based on those cases, there was no clear information how those cases spread related to environmental and demographic factor. This research aimed to do spatial analysis of DHF incidence then it was related to House Index (HI, Container Index (CI, and the density of houses and occupant. It was an observational research using survey method. This Research took 150 samples of DHF cases. The site of DHF incidence was identified using Geographic Positioning System (GPS device, to gained its coordinat. Environmental and demographic data was collected based on secondary information from District Health Office of Demak. The colected data would be analyzed spatially using ArcView GIS software. This research showed that there was no association between environmental factors (HI, CI with the Incidence Rate (IR of DHF (p-value < 0,05. However, the level of HI and CI was 13,17% and 7,08% respectively. It was a potential condition for DHF spreading in the community. Spatial analysis indicated that Mranggen Sub-district had the most number of DHF incidence that the pattern of spreading covered all area of villages. The higher of population and house density, the higher of Incidence Rate of DHFKeywords : spatial analysis of DHF, environmental factors, DemakAbstrakDemam berdarah dengue (DBD masih merupakan permasalahan serius di Kabupaten Demak Pripinsi Jawa Tengah. Pada tahun 2012, Di Kabupaten Demak terdapat 483 kasus DBD dengan 6 kematian, namun belum diketahui bagaimana sebaran kasus tersebut secara spasial dikaitkan dengan faktor lingkungan dan demografi. Penelitian ini bertujuan untuk melakukan analisis spasial kejadian DBD yang dihubungkan dengan House Index (HI, Container Index (CI, kepadatan penduduk dan kepadatan rumah. Penelitian ini merupakan penelitian observasional dengan metode

  1. Recent advances in alveolar biology: evolution and function of alveolar proteins.

    Science.gov (United States)

    Orgeig, Sandra; Hiemstra, Pieter S; Veldhuizen, Edwin J A; Casals, Cristina; Clark, Howard W; Haczku, Angela; Knudsen, Lars; Possmayer, Fred

    2010-08-31

    This review is focused on the evolution and function of alveolar proteins. The lung faces physical and environmental challenges, due to changing pressures/volumes and foreign pathogens, respectively. The pulmonary surfactant system is integral in protecting the lung from these challenges via two groups of surfactant proteins - the small molecular weight hydrophobic SPs, SP-B and -C, that regulate interfacial adsorption of the lipids, and the large hydrophilic SPs, SP-A and -D, which are surfactant collectins capable of inhibiting foreign pathogens. Further aiding pulmonary host defence are non-surfactant collectins and antimicrobial peptides that are expressed across the biological kingdoms. Linking to the first symposium session, which emphasised molecular structure and biophysical function of surfactant lipids and proteins, this review begins with a discussion of the role of temperature and hydrostatic pressure in shaping the evolution of SP-C in mammals. Transitioning to the role of the alveolus in innate host defence we discuss the structure, function and regulation of antimicrobial peptides, the defensins and cathelicidins. We describe the recent discovery of novel avian collectins and provide evidence for their role in preventing influenza infection. This is followed by discussions of the roles of SP-A and SP-D in mediating host defence at the alveolar surface and in mediating inflammation and the allergic response of the airways. Finally we discuss the use of animal models of lung disease including knockouts to develop an understanding of the role of these proteins in initiating and/or perpetuating disease with the aim of developing new therapeutic strategies. PMID:20433956

  2. Alveolar recruitment in pulmonary contusion: case report and literature review.

    Science.gov (United States)

    Trindade, Lívia Maria Vitório; Lopes, Lucianne Cristina da Silva; Cipriano, Graziella França Bernardelli; Vendrame, Letícia Sandre; Andrade Junior, Ary

    2009-03-01

    Treatment of pulmonary contusion when adequately established is very simple in most cases. Pathophysiological changes occur as a result of the effects produced by loss of chest wall integrity, accumulation of fluid in the pleural cavity, obstruction of the airways and lung dysfunction. The alveolar recruitment maneuver is the reopening of collapsed lung areas by increasing inspiratory pressure in the airway. The primary objective of this case report was to evaluate the effectiveness of the alveolar recruitment maneuver in a patient with pulmonary contusion. A 33 year old male patient, with a clinical condition of bilateral chest trauma and traumatic brain injury, evolved with reduction of the level of consciousness, acute respiratory failure, hypovolemic shock and hemoptysis. The patient underwent thoracentesis, bilateral thoracic drainage and was also submitted to invasive mechanical ventilation. After 48 hours of invasive mechanical ventilation, in accordance with protective strategy an alveolar recruitment maneuver mode, pressure-controlled ventilation, pressure controlled 10 cmH2O, respiratory rate 10 rpm, inspiratory time 3.0, positive end-expiratory pressure 30 cmH2O and FI0(2) 100%, for two minutes. After the alveolar recruitment maneuver, the patient presented clinical pulmonary improvement, but there was a variation of 185 to 322 of Pa0(2)/FiO2 (arterial partial pressure of oxygen/ fraction of inspired oxygen). He was discharged from the intensive care unit 22 days after admission. The alveolar recruitment maneuver in this patient showed significant results in the treatment of pulmonary contusion, improving blood oxygenation, preventing alveolar collapse and reversing atelectasis. PMID:25303136

  3. Alveolar macrophage kinetics and function after interruption of canine marrow function

    International Nuclear Information System (INIS)

    To study the kinetics and function of alveolar macrophages after interruption of marrow function, we performed serial bronchoalveolar lavages in dogs. The studies were performed before and after 9.0 to 9.5 Grey total body irradiation and marrow infusion. Monocytes had disappeared from the bloodstream by Day 7 after the irradiation. Alveolar macrophages were significantly decreased at Day 21. At Days 14 and 21 myeloperoxidase-positive alveolar macrophages were also significantly decreased. Beyond Day 30 the number of circulating monocytes, myeloperoxidase-positive and total alveolar macrophages had returned. Sex chromatin stains of alveolar macrophages obtained from a male dog that received female marrow indicated that the repopulating macrophages were of marrow origin. In vitro studies of alveolar macrophage migration and phagocytosis demonstrated increased activities beyond Day 30. These studies suggest that in this model the alveolar macrophage is dependent on the bone marrow for support and that the alveolar macrophage depletion may impair lung defense mechanisms

  4. Reconstruction of alveolar defects in patients with cleft lip and palate - 111 consecutive patients

    DEFF Research Database (Denmark)

    Andersen, Kristian

    2012-01-01

    Reconstruction of alveolar defects in patients with cleft lip and palate - 111 consecutive patients......Reconstruction of alveolar defects in patients with cleft lip and palate - 111 consecutive patients...

  5. Use of Induced Pluripotent Stem Cells to Recapitulate Pulmonary Alveolar Proteinosis Pathogenesis

    OpenAIRE

    Suzuki, Takuji; Mayhew, Christopher; Sallese, Anthony; Chalk, Claudia; Carey, Brenna C.; Malik, Punam; Wood, Robert E.; Trapnell, Bruce C.

    2014-01-01

    Rationale: In patients with pulmonary alveolar proteinosis (PAP) syndrome, disruption of granulocyte/macrophage colony–stimulating factor (GM-CSF) signaling is associated with pathogenic surfactant accumulation from impaired clearance in alveolar macrophages.

  6. Alveolar epithelial permeability in bronchial asthma in children

    International Nuclear Information System (INIS)

    To evaluate alveolar epithelial permeability (kep) in children with bronchial asthma, 99mTc-DTPA (diethylene triamine penta acetate) aerosol lung inhalation scintigraphies were performed. There was no correlation between the kep value and the severity of asthma. On the other hand, out of 10 cases which had no aerosol deposition defect in the lung field, 4 showed high kep values on the whole lung field and 7 had high kep value areas, particularly apparent in the upper lung field. These results suggest that even when the central airway lesions are mild, severe damage exists in the alveolar region of the peripheral airway. (author)

  7. Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome

    Institute of Scientific and Technical Information of China (English)

    XIE Li-xin; ZHAO Tie-mei; WANG Qiao-yun; CHEN Liang-an; LI Ai-min; WANG Dian-jun; QI Fei; LIU You-ning

    2007-01-01

    @@ Pulmonary alveolar proteinosis (PAP) is an uncommon disease first reported by Rosen et al 1 in 1958, and characterized by the accumulation of surfactant proteins and phospholipids within the alveolar spaces. Acquired PAP is divided into two forms based on clinical features:idiopathic PAP and secondary PAP. Secondary PAP is reported to be associated with haematological malignancies, Pneumocystis carinii pneumonia and inhalation of silica or titanium, and the most frequent underlying disease of secondary PAP is haematological malignancy. The exact incidence of PAP in haematological malignancies is still obscure, since there have been only sporadic reports of secondary PAP. 2, 3

  8. Repopulation of denuded tracheal grafts with alveolar type II cells

    International Nuclear Information System (INIS)

    Repopulation of denuded heterotopic tracheal grafts with populations of specific epithelial cell types is one approach to study the differentiation potential of various cell types. This technique has been adopted to delineate the differentiation pathways of alveolar type II cells isolated from rat lungs. Under the conditions of this experiment, the reestablished epithelial lining was alveolar-like, however, ultrastructural analysis of the cells showed them to be like Clara cells. These preliminary results suggest that the secretary cells of the lung parenchyma and terminal airways may share a common ancestry. (author)

  9. Low Levels of IGF-1 Contribute to Alveolar Macrophage Dysfunction in Cystic Fibrosis1

    OpenAIRE

    Bessich, Jamie L.; Nymon, Amanda B.; Moulton, Lisa A; Dorman, Dana; Ashare, Alix

    2013-01-01

    Alveolar macrophages are major contributors to lung innate immunity. Although alveolar macrophages from CFTR−/− mice have impaired function, no study has investigated primary alveolar macrophages in adults with cystic fibrosis (CF). CF patients have low levels of insulin-like growth factor 1 (IGF-1), and our prior studies demonstrate a relationship between IGF-1 and macrophage function. We hypothesize that reduced IGF-1 in CF leads to impaired alveolar macrophage function and chronic infectio...

  10. Analisis Komparatif Biaya Hutang Sukuk Dan Obligasi Perusahaan

    Directory of Open Access Journals (Sweden)

    Burhanuddin Jiwandaru

    2014-03-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui perbandingan biaya hutang sukuk dibandingkan dengan obligasi sebagai sumber dana bagi perusahaan. Objek pada penelitian ini adalah seluruh sukuk dan obligasi korporasi yang diterbitkan perusahaan-perusahaan di Indonesia sejak Oktober 2006 sampai Juli 2010. Metode yang dilakukan dalam penelitian ini ialah dengan membandingkan rata-rata biaya hutang sukuk dengan rata-rata biaya hutang obligasi pada perusahaan. Hasil analisis data menunjukan bahwa rata-rata biaya hutang dari seluruh sukuk hampir sama daripada rata-rata biaya hutang dari seluruh obligasi. Bedasarkan data penelitian juga terdapat 21 obligasi yang memiliki biaya hutang yang sama dengan biaya hutang sukuknya, dan hanya terdapat dua obligasi memiliki biaya hutang yang sedikit lebih tinggi dari biaya hutang sukuknya.JEL Classification : G10, G14, G30Keywords : Biaya Hutang, Obligasi, Sukuk

  11. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI INDEPENDENSI PENAMPILAN AKUNTAN PUBLIK

    Directory of Open Access Journals (Sweden)

    Ardiani Ika S.

    2012-03-01

    Full Text Available Tujuan dari penelitian ini adalah untuk menguji secara empiris faktor-faktor yang mempengaruhi independensi penampilan akuntan publik baik secara parsial dan simultan. Faktor-faktor tersebut adalah financial interests, hubungan bisnis dengan klien, pelayanan asuransi dan audit, hubungan antara klien atau yg diaudit dengan auditor, kompetisi antara Kantor Akuntan Publik (KAP, ukuran KAP dan audit fee. Populasi dalam penelitian ini adalah para auditor di akuntan publik di Semarang tahun 2009. Metode penyeleksian sampel yang digunakan adalah convenience sampling dan jumlah respondennya 35. Alat analisis yang digunakan adalah multiple regression analysis. Dimulai dengan analisis kuantitatif untuk mengetes validitas dan reabilitas. Kemudian dilanjutkan uji asumsi klasik termasuk normality, multicollinearity, and heteroscedastisity. Hasil menunjukkan bahwa 6 variabel yang sudah dikaji secara simultan dan partial tersebut mempunyai efek yang signifikan terhadap independensi penampilan akuntan publik dengan R square 0.749. The objective of this study is to test empirically the factors that influence the independence of public accountant appearance both partially and simultaneously. The factors cover financial interests, business relationships with clients, assurance services and audit services, the length of relationship between client or auditee and auditor, the competition between Public Accountan Offices (KAPs, the size of KAP, and audit fee. The population in this study was the auditors who worked in the public accountant’s office in Semarang in 2009. The sample selection method is a convenience sampling and the  number of  respondents are 35. The Analysis tools used is multiple regression analysis. It starts by applying quantitative analysis to test the validity and reliability. Then, it is continued by testing the classical assumptions which include normality, multicollinearity, and heteroscedastisity. The result shows that the six

  12. ANALISIS KENDALA POTENSIAL PENERAPAN TOTAL QUALITY MANAGEMENT HOTEL PLAZA SEMARANG

    Directory of Open Access Journals (Sweden)

    Hendrajaya -

    2010-03-01

    Full Text Available Penelitian ini bertujuan untuk menemukan faktor-faktor yang terbentuk dari kendala penerapan Total Quality Management (TQM, sebagai upaya untuk menganalisis masalah-masalah potensial dari penerapan TQM di Hotel Plaza, Semarang. Sampel dari penelitian ini sejumlah 65 karyawan Hotel Plaza, Semarang yang terdiri dari manajer dan staf. Teknik analisis menggunakan Faktor Analisis. Hasil penelitian menunjukkan, bahwa kendala potensial dari implementasi TQM dapat disimpulkan menjadi lima faktor, yaitu faktor inkonsistensi, visi-misi, transformasi budaya, manajerial dan manajemen kualitas. Penelitian ini memberikan rekomendasi bahwa peningkatan fungsi-fungsi korporat melalui optimalisasi kualitas sebagai strategi bisnis dan orientasi pada kepuasan konsumen dengan melibatkan seluruh anggota organisasi, akan menjadi dasar untuk memaksimalkan daya saing perusahaan dalam hal produk, layanan, SDM, lingkungan dan seluruh proses yang dapat mendukung upaya perbaikan produktivitas. This study aims to determine the constraint factors and to analyze the potential problems of TQM implementation of Plaza Semarang Hotel. The sample of 65 employees of TQM implementation of Plaza Semarang Hotel, consist of managers and staffs. Factor analysis is used to achieve the results of the potential constraint implementation of Total Quality Management which can be summarized into five factors, they are: the factor of inconsistencies, the factor of vision and mission, cultural transformation factors, managerial factors and the factors of quality management. In order to increase the corporate functions through the optimization of quality as a business strategy and to achieve customer satisfaction, this study suggests that all members of the organization should be involved by the company as on-going basis to maximize the competitiveness of the organization on products, services, human resources, environment and all processes that support productivity improvement.

  13. ENCAPAI SUMBER DAYA MANUSIA UNGGUL (ANALISIS KINERJA DAN KUALITAS PELAYANAN

    Directory of Open Access Journals (Sweden)

    Ketut Sudarma

    2012-03-01

    Full Text Available Penelitian ini  bertujuan untuk menganalisis pengaruh kemampuan individu, kepuasan kerja, komitmen organisasi terhadap kinerja dan kinerja terhadap kualitas pelayanan. Sampel penelitian berjumlah 76 orang. Teknik pengambilan sampel menggunakan proportional random sampling. Variabel penelitian terdiri dari kemampuan individu, kepuasan kerja, komitmen organisasi, dan kinerja serta kualitas pelayanan  Analisis data menggunakan regresi dua tahap. Hasil penelitian menunjukkan bahwa kemampuan individu, kepuasan kerja dan komitmen organisasi mempunyai pengaruh positif signifikan terhadap kinerja dan kinerja berpengaruh positif signifikan terhadap kualitas pelayanan. Ini berarti semakin meningkat kinerja, maka semakin meningkat juga kualitas pelayanan. Dari hasil analisis deskriptif persentase tampak secara rata-rata  semua variabel penelitian  menunjukkan kategori baik, namun pada aspek-aspek tertentu pada masing-masing variabel masih terdapat kekurangan. Hasil penelitian ini diharapkan dapat menjadi masukan bagi pimpinan dalam meningkatkan kinerja dan kualitas pelayanan. Upaya perbaikan dimulai dari peningkatan kemampuan melalui pendidikan dan latihan, monitoring pelaksanaan kerja secara rutin, menumbuhkan komitmen kerja dan perbaikan standar operasi prosedur.The aim of the study is toanalyze the influence of individual abilities, job satisfaction, organizational commitment to performanceand performance againstservice quality. This samplingmethod is using 76 samples by the proportionalrandom sampling techniques. Variables consisted of individual ability, job satisfaction, organizational commitment, and performance andservice qualitydata analysisusingtwo-stageregression. The results showedthat theability of individuals, job satisfaction and organizational commitment had asignificant positive effecton performance and the performance ofa significant positive effecton quality of service. It means the higher performance, the higher service

  14. Unsuspected pulmonary alveolar proteinosis in a patient with acquired immunodeficiency syndrome: a case report

    OpenAIRE

    Niazi Masooma; DeLaCruz Angel E; Tejwani Dimple; Diaz-Fuentes Gilda

    2011-01-01

    Abstract Introduction Diffuse lung infiltrates are a common finding in patients with acquired immunodeficiency syndrome and causes range from infectious processes to malignancies or interstitial lung diseases. Pulmonary alveolar proteinosis is a rare pulmonary disorder rarely reported in patients infected with human immunodeficiency virus. Secondary pulmonary alveolar proteinosis is associated with conditions involving functional impairment or reduced numbers of alveolar macrophages. It can b...

  15. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia.

    Science.gov (United States)

    Davis, K Rennis; Vadakkan, D Thomas; Krishnakumar, E V; Anas, A Muhammed

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia. PMID:25814803

  16. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia

    OpenAIRE

    K Rennis Davis; D Thomas Vadakkan; Krishnakumar, E. V.; A Muhammed Anas

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia.

  17. Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia

    Directory of Open Access Journals (Sweden)

    K Rennis Davis

    2015-01-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia.

  18. Meta Analisis sa Pagsusuri ng Maiikling Kwento sa mga Tesis at Disertasyon

    Directory of Open Access Journals (Sweden)

    Regina I. Cuizon

    2014-10-01

    Full Text Available Anumang mga pagbabago na makikita sa mundo ay bunga ng pananaliksik. Ang meta-analisis ay isa sa mga bunga ng pananaliksik na ginagamit sa kasalukuyan bilang teknik upang malaman iba pang mga nagsulputang informasyon. Ito’y pag-aaral sa mga pag-aaral. Isang kritikal at sistematikong pagsusuri sa istruktura ng mga pag-aaral. Maging gabay sa mga gradwadong paaralan sa pagpili ng paksang pagaaralan. Pangunahing layunin na matiyak ang mga pamamaraan sa pagsusuri ng maiikling kwento ng mga tesis at disertasyong nagawa mula sa mga piling SUCs. Desinyong kwalitatibo - kontent analisis sa pagsusuri ng: kaanyuan ayon sa suliranin, metodolohiya, paglalahad at interpretasyon ng mga datos, natuklasan, konklusyon, at rekomendasyon; kahinatnan ayon sa pagkatulad, pagkakaiba at kabuluhan; Emerging tema. Napag-alaman na ang karaniwang pinag-aralan ay 30% kahalagahang pangkatauhan, 20% larawangdiwa ng mga kababaihan at 10% gramatikang aspeto. Sa metodolohiyang ginamit, 80% desinyong kwalitatibo at 20% kwantitatibo-kwalitatibo. Sa paglikom ng datos 60% diretsahang pagsusuri, 30% talatanungan at 10% tseklis. Sa pag-analisa 90% kontent analisis at 10% gramatikal analisis. Batay sa natuklasan, ang pagsusuri ng maiikling kwento sa mga tesis at disertasyon mula sa iba’t ibang paaralan gamit ang meta analisis ay isang epektibo, mabisa, objektibong paraan at kagamitan na magagamit sa makatarungang paghatol; pamumuna sa kabuluhan at kagandahan; paghaham- bing sa mga kritikal na isyu; at pormulasyon ng panibagong pamantayan at batas.

  19. Pulmonary alveolar proteinosis in an indium-processing worker

    Institute of Scientific and Technical Information of China (English)

    XIAO Yong-long; CAI Hou-rong; WANG Yi-hua; MENG Fan-qing; ZHANG De-ping

    2010-01-01

    @@ With the increasing number of workers engaged in liquid-crystal displays (LCD) manufacturer, lung diseases related to this occupational exposure are attracting more attention.Herein we report a case of interstitial lung disease in a LCD processing worker, which was pathologically confirmed as pulmonary alveolar proteinosis (PAP).

  20. Alveolar ridge augmentation in rats by Bio-Oss

    DEFF Research Database (Denmark)

    Pinholt, E M; Bang, G; Haanaes, H R

    1991-01-01

    The purpose of the study was to examine if Bio-Oss initiated osteoinduction or osteoconduction when implanted into rats. Sintered and unsintered granules of the anorganic bovine bone Bio-Oss was implanted subperiosteally for alveolar ridge augmentation purposes and heterotopically in the abdominal...

  1. Alveolar pulmonary proteinosis: case report and literature review

    International Nuclear Information System (INIS)

    We describe the case of a young women with primary alveolar proteinosis, with a short period of symptoms that are uncommon for this disease, without risk factors for this entity, the clinical evolution of the patient and some complications with the treatment. We review the literature for this entity.

  2. Abnormal gallium scintigraphy in pulmonary alveolar proteinosis (PAP)

    International Nuclear Information System (INIS)

    A patient with medulloblastoma of the cerebellum developed dyspnea and hypoxemia. Pulmonary function tests showed decreased lung volume and diffusing capacity, while the chest radiographs initially showed only mild interstitial infiltrates. Repeated gallium scans showed diffuse lung uptake and diagnosis of pulmonary alveolar proteinosis was made by open lung biopsy

  3. CT scan patterns of pulmonary alveolar proteinosis in children

    International Nuclear Information System (INIS)

    Background. To study computed tomographic (CT) findings in children with pulmonary alveolar proteinosis (PAP) more extensively. Objective. To describe the CT features at the time of diagnosis and after therapeutic broncho-alveolar lavage (BAL). Materials and methods. We retrospectively reviewed the CT scans of five children (aged 3 months to 4 years) examined because of incidental bronchitis (n = 1), disease in a sibling (n = 1) and relapsing fever, cough and dyspnoea (n = 3). Each patient had an initial CT scan. Two asymptomatic cases were not treated but were followed up by plain chest films. The other three had BAL and follow-up CT. Results. Initial CT in all cases showed a diffuse reticulomicronodular pattern associated in three cases with posterior bilateral alveolar infiltrates. CT in the two asymptomatic patients remained unchanged or slightly improved without BAL. After BAL, a variable decrease of lung infiltrates was observed. Conclusions. Correlation between the extent of alveolar consolidation and severity of disease was found. Anatomical and pathological considerations allow us to consider that the classical reticulomicronodular pattern is not due to an interstitial infiltration but to alveoli filled with the abnormal material characteristic of PAP. (orig.)

  4. Alveolar echinococcosis localized in the liver, lung and brain

    Institute of Scientific and Technical Information of China (English)

    Seyit Mehmet Kayacan; Kutigin Turkmen; Fatih Yakar; Kerim Guier; Sezai Vatansever; Suleyman Temiz; Bora Uslu; Dilek Kayacan; Vakur Akkaya; Osman Erk; Büent Saka; Aytac Karadag

    2008-01-01

    @@ Echinococcosis is a parasitic disease caused by the larval forms of echinococci. It has two main forms as the unilocular cystic form that is more commonly seen and caused by E. granulosus and the alveolar form that is rarely seen and caused by E.

  5. Alveolar soft-part sarcoma presenting with multiple intracranial metastases

    Directory of Open Access Journals (Sweden)

    Sujit Kumar G

    2004-04-01

    Full Text Available A 28-year-old man presented with history of raised intracranial pressure and one episode of generalized tonic clonic seizures. Computed Tomogram revealed multiple contrast enhancing intracranial lesions. Biopsy of one of the lesions was reported as metastatic alveolar soft part sarcoma. He was advised whole brain radiotherapy.

  6. Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis.

    Science.gov (United States)

    Vadrevu, Surya Kumari; Sharma, Sharad; Chintala, Navin; Patel, Jalpa; Karbowniczek, Magdalena; Markiewski, Maciej

    2016-01-01

    This paper describes the application of the syngeneic model of breast cancer (4T1) to the studies on a role of pulmonary alveolar macrophages in cancer metastasis. The 4T1 cells expressing GFP in combination with imaging and confocal microscopy are used to monitor tumor growth, track metastasizing tumor cells, and quantify the metastatic burden. These approaches are supplemented by digital histopathology that allows the automated and unbiased quantification of metastases. In this method the routinely prepared histological lung sections, which are stained with hematoxylin and eosin, are scanned and converted to the digital slides that are then analyzed by the self-trained pattern recognition software. In addition, we describe the flow cytometry approaches with the use of multiple cell surface markers to identify alveolar macrophages in the lungs. To determine impact of alveolar macrophages on metastases and antitumor immunity these cells are depleted with the clodronate-containing liposomes administrated intranasally to tumor-bearing mice. This approach leads to the specific and efficient depletion of this cell population as confirmed by flow cytometry. Tumor volumes and lung metastases are evaluated in mice depleted of alveolar macrophages, to determine the role of these cells in the metastatic progression of breast cancer. PMID:27403530

  7. Alveolar macrophages in rabbits exposed to nickel dust

    Energy Technology Data Exchange (ETDEWEB)

    Camner, P.; Johansson, A.; Lundborg, M.

    1978-07-01

    Two groups of four rabbits each were exposed to 0.5 and 2.0 mg/m/sup 3/ of metallic nickel dust respectively, for 4 weeks (5 days/week, 6 hours/day). About half of the particle masses penetrated a Casella preseparator. After exposure the lungs were extracted and lavaged. Compared to four control rabbits significant effects were seen in both exposed groups with regard to lung weight and density as well as phagocytic activity, size distribution, and ultrastructure of the alveolar macrophages (numerous slender microvilli and long protrusions from the cell surface and laminated structures similar to those seen in alveolar type II cells). The effects on the macrophages were probably not caused directly by nickel. The lung washing from the exposed rabbits contained an amorphous substance rich in phospholipids and laminated structures. Apart from the ultrastructural changes the effects seemed to be dose related. The results of exposure to metallic nickel dust have at least some features in common with ''alveolar lipoproteinosis,'' described in rats exposed to silica dust, and with ''pulmonary alveolar proteinosis,'' described in man.

  8. Abnormal gallium scintigraphy in pulmonary alveolar proteinosis (PAP)

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, S.D.; White, D.A.; Stover-Pepe, D.E.; Caravelli, J.F.; Van Uitert, C.; Benua, R.S.

    1987-04-01

    A patient with medulloblastoma of the cerebellum developed dyspnea and hypoxemia. Pulmonary function tests showed decreased lung volume and diffusing capacity, while the chest radiographs initially showed only mild interstitial infiltrates. Repeated gallium scans showed diffuse lung uptake and diagnosis of pulmonary alveolar proteinosis was made by open lung biopsy.

  9. Anti-GM-CSF antibodies in paediatric pulmonary alveolar proteinosis

    OpenAIRE

    Latzin, P; Tredano, M.; Wust, Y; J. de Blic; Nicolai, T; Bewig, B; Stanzel, F.; Kohler, D.; Bahuau, M.; Griese, M

    2005-01-01

    Background: Auto-antibodies against granulocyte-macrophage colony stimulating factor (GM-CSF) may be central to the pathogenesis of adult sporadic pulmonary alveolar proteinosis (PAP). The role of anti-GM-CSF auto-antibodies in paediatric forms of PAP is as yet unclear.

  10. CT scan patterns of pulmonary alveolar proteinosis in children

    Energy Technology Data Exchange (ETDEWEB)

    Albafouille, V.; Sayegh, N.; Coudenhove, S. de; Mamou-Mani, T.; Hassine, A.; Brunelle, F. [Hopital Necker-Enfants Malades, Paris (France). Dept. of Paediatric Radiology; Scheinmann, P.; Blic, J. de [Hopital Necker-Enfants Malades, Paris (France). Dept. of Pneumology; Jaubert, F. [Hopital Necker-Enfants Malades, Paris (France). Dept. of Pathology

    1999-03-01

    Background. To study computed tomographic (CT) findings in children with pulmonary alveolar proteinosis (PAP) more extensively. Objective. To describe the CT features at the time of diagnosis and after therapeutic broncho-alveolar lavage (BAL). Materials and methods. We retrospectively reviewed the CT scans of five children (aged 3 months to 4 years) examined because of incidental bronchitis (n = 1), disease in a sibling (n = 1) and relapsing fever, cough and dyspnoea (n = 3). Each patient had an initial CT scan. Two asymptomatic cases were not treated but were followed up by plain chest films. The other three had BAL and follow-up CT. Results. Initial CT in all cases showed a diffuse reticulomicronodular pattern associated in three cases with posterior bilateral alveolar infiltrates. CT in the two asymptomatic patients remained unchanged or slightly improved without BAL. After BAL, a variable decrease of lung infiltrates was observed. Conclusions. Correlation between the extent of alveolar consolidation and severity of disease was found. Anatomical and pathological considerations allow us to consider that the classical reticulomicronodular pattern is not due to an interstitial infiltration but to alveoli filled with the abnormal material characteristic of PAP. (orig.) With 3 figs., 1 tab., 16 refs.

  11. Bronchoalveolar lavage with trypsin in pulmonary alveolar proteinosis.

    OpenAIRE

    Nagasaka, Y.; Takahashi, M; Ueshima, H; Tohda, Y.; Nakajima, S.

    1996-01-01

    Two cases of pulmonary alveolar proteinosis were treated with bronchoalveolar lavage (BAL) via a fibreoptic bronchoscope. Additional clinical improvement was seen when trypsin was added to the lavage fluid. Analysis of effluents in the BAL fluid showed marked reduction of protein constituents with clinical improvement after treatment with trypsin in the lavage. BAL with trypsin was well tolerated.

  12. Alveolar occupation infiltrations, eosinophilia in peripheral blood and bronchoalveolar lavage

    International Nuclear Information System (INIS)

    A case of a patient of 25 years old is shown with the antecedent of no potable water consumption who entered for having pulmonary symptoms. Fever, presence of alveolar occupation infiltrations and eosinophilia in peripheral blood a treatment with antiparasitary started with a significant improvement of the symptoms, infiltrations and eosinophilia. it is considered eosinophilic pneumonia diagnostic by parasitary infection (Loeffler's syndrome)

  13. Alveolar occupation infiltrations, eosinophilia in peripheral blood and bronchoalveolar lavage

    International Nuclear Information System (INIS)

    A case of a patient of 25 years old is shown with the antecedent of no potable water consumption who entered for having pulmonary symptoms, fever, presence of alveolar occupation infiltrations and eosinophilia in peripheral blood treatment with antiparasitary started with a significant improvement of the symptoms, infiltrations and eosinophilia. It is considered eosinophilic pneumonia diagnostic by parasitary infection (Loefffers Syndrome)

  14. Biomimetics of fetal alveolar flow phenomena using microfluidics.

    Science.gov (United States)

    Tenenbaum-Katan, Janna; Fishler, Rami; Rothen-Rutishauser, Barbara; Sznitman, Josué

    2015-01-01

    At the onset of life in utero, the respiratory system begins as a liquid-filled tubular organ and undergoes significant morphological changes during fetal development towards establishing a respiratory organ optimized for gas exchange. As airspace morphology evolves, respiratory alveolar flows have been hypothesized to exhibit evolving flow patterns. In the present study, we have investigated flow topologies during increasing phases of embryonic life within an anatomically inspired microfluidic device, reproducing real-scale features of fetal airways representative of three distinct phases of in utero gestation. Micro-particle image velocimetry measurements, supported by computational fluid dynamics simulations, reveal distinct respiratory alveolar flow patterns throughout different stages of fetal life. While attached, streamlined flows characterize the shallow structures of premature alveoli indicative of the onset of saccular stage, separated recirculating vortex flows become the signature of developed and extruded alveoli characteristic of the advanced stages of fetal development. To further mimic physiological aspects of the cellular environment of developing airways, our biomimetic devices integrate an alveolar epithelium using the A549 cell line, recreating a confluent monolayer that produces pulmonary surfactant. Overall, our in vitro biomimetic fetal airways model delivers a robust and reliable platform combining key features of alveolar morphology, flow patterns, and physiological aspects of fetal lungs developing in utero. PMID:25759753

  15. Increased alveolar soluble annexin V promotes lung inflammation and fibrosis.

    Science.gov (United States)

    Buckley, Susan; Shi, Wei; Xu, Wei; Frey, Mark R; Moats, Rex; Pardo, Annie; Selman, Moises; Warburton, David

    2015-11-01

    The causes underlying the self-perpetuating nature of idiopathic pulmonary fibrosis (IPF), a progressive and usually lethal disease, remain unknown. We hypothesised that alveolar soluble annexin V contributes to lung fibrosis, based on the observation that human IPF bronchoalveolar lavage fluid (BALF) containing high annexin V levels promoted fibroblast involvement in alveolar epithelial wound healing that was reduced when annexin V was depleted from the BALF. Conditioned medium from annexin V-treated alveolar epithelial type 2 cells (AEC2), but not annexin V per se, induced proliferation of human fibroblasts and contained pro-fibrotic, IPF-associated proteins, as well as pro-inflammatory cytokines that were found to correlate tightly (r>0.95) with annexin V levels in human BALF. ErbB2 receptor tyrosine kinase in AECs was activated by annexin V, and blockade reduced the fibrotic potential of annexin V-treated AEC-conditioned medium. In vivo, aerosol delivery of annexin V to mouse lung induced inflammation, fibrosis and increased hydroxyproline, with activation of Wnt, transforming growth factor-β, mitogen-activated protein kinase and nuclear factor-κB signalling pathways, as seen in IPF. Chronically increased alveolar annexin V levels, as reflected in increased IPF BALF levels, may contribute to the progression of IPF by inducing the release of pro-fibrotic mediators. PMID:26160872

  16. Alveolar bone measurement precision for phosphor-plate images

    Science.gov (United States)

    HILDEBOLT, CHARLES F.; COUTURE, REX; GARCIA, NATHALIA M.; DIXON, DEBRA; SHANNON, WILLIAM DOUGLAS; LANGENWALTER, ERIC; CIVITELLI, ROBERTO

    2009-01-01

    Objectives To demonstrate methods for determining measurement precision and to determine the precision of alveolar-bone measurements made with a vacuum-coupled, positioning device and phosphor-plate images. Study design Subjects were rigidly attached to the x-ray tube by means of a vacuum coupling device and custom, cross-arch, bite plates. Original and repeat radiographs (taken within minutes of each other) were obtained of the mandibular posterior teeth of 51 subjects, and cementoenamel-junction-alveolar-crest (CEJ-AC) distances were measured on both sets of images. In addition, x-ray-transmission (radiodensity) and alveolar-crest-height differences were determined by subtracting one image from the other. Image subtractions and measurements were performed twice. Based on duplicate measurements, the root-mean-square standard deviation (precision) and least-significant change (LSC) were calculated. LSC is the magnitude of change in a measurement needed to indicate that a true biological change has occurred. Results The LSCs were 4% for x-ray transmission, 0.49 mm for CEJ-AC distance, and 0.06 mm for crest-height 0.06 mm. Conclusion The LSCs for our CEJ-AC and x-ray transmission measurements are similar to what has been reported. The LSC for alveolar-crest height (determined with image subtraction) was less than 0.1 mm. Compared with findings from previous studies, this represents a highly precise measurement of alveolar crest height. The methods demonstrated for calculating LSC can be used by investigators to determine how large changes in radiographic measurements need to be before the changes can be considered (with 95% confidence) true biological changes and not noise (that is, equipment/observer error). PMID:19716499

  17. Secondary Alveolar Bone Grafting and Iliac Cancellous Bone Harvesting for Patients With Alveolar Cleft.

    Science.gov (United States)

    Pan, Weiyi; Wu, Chenzhou; Yang, Zheng; Duan, Zexi; Su, Zhifei; Wang, Peiqi; Zheng, Qian; Li, Chunjie

    2016-06-01

    To assess the efficacy of present interventions optimizing the result of secondary alveolar bone grafting (SABG) and the interventions alleviating the donor site morbidity after iliac cancellous bone harvesting. Researches were identified by searching the electronic database of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Chinese BioMedical Literature Database, and the China National Knowledge Infrastructure. In addition, relevant journals and references of the included studies were searched manually. The Oxford 2011 Levels of Evidence were applied to assess the methodological quality of selected studies, and the best evidence synthesis system was applied afterward to measure the strength of evidence. As a result, 42 studies were considered eligible and included, among which 4 were of high quality while 38 were of low quality. Thirty lines of evidences were acquired after the synthesis, among which 13 were rated as moderate while 17 were rated as insufficient. As for the interventions optimizing the result of SABG, moderate evidence confirmed the efficacy of preoperative orthodontic treatment, the superiority of performing SABG before the eruption of canine, and the accuracy of cone beam computed tomography in preoperative estimation of the cleft volume. As for the interventions alleviating the morbidity of iliac cancellous bone harvesting, moderate evidence confirmed the treatment benefit of the interventions below: minimally invasive technique, including trephine and Shepard osteotomy; preemptive analgesia, including continuous bupivacaine infusion or transversus abdominis plane block. As for the rest interventions, only insufficient evidence was found. PMID:27244214

  18. Analisis dan Desain BI-Dashboard Monitoring Realisasi Daftar Isian Pelaksanaan Anggaran (DIPA pada Kantor Pelayanan Perbendaharaan Negara (KPPN

    Directory of Open Access Journals (Sweden)

    Ernestina Rahmanasari

    2013-09-01

    Full Text Available Transaksi keuangan badan pemerintahan tingkat daerah dipertanggungjawabkan kepada Kementrian Keuangan melalui Kantor Pelayanan Perbendaharaan Negara (KPPNsetiap bulan dalam bentuk Laporan Keuangan Pemerintah Pusat (LKPP. Laporan Keuangan, didukung dengan teknologi Business Intelligence(BI dashboarddapat dimanfaatkan sebagai data-driven decision support system yang mendorong performa kinerja. Analisis dan desainterhadap pembuatan BI dashboard menunjukkanbagaimana Laporan Keuangan dapat digunakan untuk monitoring realisasi penyerapan dana DIPA dan kinerja instansi secara tepat waktu dan interaktif.Analisis terdiri dari analisis Indikator Kinerja Utama (IKU dan analisis Laporan Keuangan. IKUpada analisis dan desain ini mencakup ketercapaian estimasi dengan penerimaan, ketercapaian pagu dengan belanja, ketepatan waktu pengiriman rekonsiliasi oleh instansi, validasi, akurasi, dan ketepatan data. Desain terdiri dari katalog dashboard, alur analisis, sumber data, desain User-Interface, dan desain objek dashboard. Sedangkan dashboard yang dirancang menggunakan aplikasi Vera sebagai Enterprise System, mengakses basis data MySQL, dan menampilkan data dengan teknologi data-driven business-intelligence Qlikview. Desain aplikasi yang telah dibuat akan menampilkan 4 (empat Tab yaitu: Dashboard utama, Analisis, Monitoring, dan Laporan

  19. Characteristic aspects of alveolar proteinosis diagnosis Aspectos característicos do diagnóstico da proteinose alveolar

    Directory of Open Access Journals (Sweden)

    Thiago Prudente Bártholo

    2012-02-01

    Full Text Available Alveolar proteinosis is an uncommon pulmonary disease characterized by an accumulation of surfactant in terminal airway and alveoli, thereby impairing gas exchange and engendering respiratory insufficiency in some cases. Three clinically and etiologically distinct forms of pulmonary alveolar proteinosis are recognized: congenital, secondary and idiopathic, the latter corresponding to 90% of the cases. In this case report we present a young male patient that was diagnosed with alveolar proteinosis. Computed tomography of the thorax, bronchoscopy and transbronchial biopsy were performed. The histopathologic aspect was characteristic. The patient was discharged in good health conditions and remains asymptomatic to date.Proteinose alveolar é uma doença pulmonar incomum caracterizada pelo acúmulo de surfactante nas vias aéreas terminais e nos alvéolos, alterando a troca gasosa e, em alguns casos, promovendo insuficiência respiratória. Três formas clínicas e etiologicamente distintas de proteinose alveolar são reconhecidas: congênitas, secundárias e idiopáticas (mais de 90% dos casos são de etiologia idiopática. Neste relato, apresentamos um homem jovem que foi diagnosticado com proteinose pulmonar. Tomografia computadorizada de tórax, broncoscopia e biópsia transbrônquica foram realizadas. O aspecto histopatológico foi característico. O paciente teve alta, com boas condições de saúde, e encontra-se assintomático nos dias de hoje.

  20. ANALISIS STEGANOGRAFI METODE LEAST SIGNIFICANT BIT (LSB DENGAN PENYISIPAN SEKUENSIAL DAN ACAK SECARA KUANTITATIF DAN VISUAL

    Directory of Open Access Journals (Sweden)

    Erwin Yudi Hidayat

    2013-08-01

    Full Text Available Penelitian ini bertujuan untuk melakukan analisis terhadap steganografi Least Significant Bit (LSB yang mampu menyisipkan pesan secara sekuensial dan acak. Analisis dilakukan untuk mengetahui penyisipan yang manakah yang memiliki kemampuan paling baik. Secara kuantitatif, Peak Signal to Noise Ratio (PSNR digunakan untuk mengukur kualitas citra. Sedangkan secara visual, steganalisis Enhanced LSB dimanfaatkan untuk mengetahui teknik mana yang mampu menyisipkan pesan tanpa mudah dideteksi. Hasil percobaan menunjukkan, penyisipan secara acak memiliki kemampuan lebih baik daripada penyisipan secara sekuensial. Kata Kunci: steganografi, acak, sekuensial, PSNR, Enhanced LSB

  1. The role of probiotic on alveolar bone resorption

    Directory of Open Access Journals (Sweden)

    Desi Sandra Sari

    2011-09-01

    Full Text Available Background: Probiotics are microbes derived from the group of lactic acid bacteria that work to maintain the health of hosts. Probiotics can also be used to improve oral health. Periodontal disease is usually marked with gingival inflammation and alveolar bone resorption. Gram negative anaerobic bacteria that play important role in human periodontal disease are Porphyromonas gingivalis. (P. gingivalis. P. gingivalis is a virulent bacteria in vivo or in vitro, and mostly found in subgingival plaque of periodontitis patients. Purpose: This study is aimed to know the role of probiotics to inhibit the resorption of alveolar bone induced with P. gingivalis. Methods: This study used male wistar rats divided into 4 groups. Group I was control group (without treatment; group II was induced with P. gingivalis ATCC 33277 for 5 days; group III was induced with P. gingivalis ATCC 33277 and also injected with probiotics (Lactobacillus casei ATCC 4224 for 5 days simultaneously; and group IV was induced with P. gingivalis ATCC 33277 for 5 days and also injected by probiotics (Lactobacillus casei ATCC 4224 in the next 5 days. After that, the samples were decapitated, taken their alveolar bone, and then were examined by immunohistochemistry to observe osteoclast activity in alveolar bone resorption by using tartrate-resistant acid phosphatase (TRAP expression. All data were then analyzed statistically. Results: It is known that there were significant differences of TRAP expression among all those treatment groups (p < 0.05. Conclusion: It then can be concluded that probiotics can decrease osteoclast activity in periodontal tissue of wistar rats, so it can inhibit alveolar bone resorption.Latar belakang: Probiotik adalah mikroba dari golongan bakteri asam laktat yang bekerja mempertahankan kesehatan host dan probiotik dapat digunakan untuk meningkatkan kesehatan rongga mulut. Penyakit periodontal ditandai dengan adanya keradangan pada gingiva dan resobsi tulang

  2. Analisis komoditas unggulan perikanan budidaya Kabupaten Pidie Jaya

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    Farok Afero

    2015-06-01

    Full Text Available Abstract. Snapper (Lates calcarifer, grouper (Epinephelus coioides, tiger shrimp (Penaeus monodon, vannamei shrimp (Litopenaeus vannamei and tilapia (Oreochromis niloticus are leading commodity worthly cultivated in Pidie Jaya. Bandar Baru and Tringgadeng an appropriate areas for black tiger shrimp while Jangka Buya and Ulim approriate areas for vannamei cultivation. AHP analysis showed black tiger shrimp is top priority based on the economic value while vannamei shrimp is top priority based on enterprise sustainability. Financial analysis of snapper, grouper, black tiger shrimp, vannamei shrimp and tilapia farming generated positive cash flow and NPV, IRR > 100%, the ratio of benefit to cost of production > 1,30 and payback period of investment costs  < 1 year, thus demonstrating the feasibility of cultivation of these leading commodities. Vannamei shrimp cultivation showed positive prospect as long the market offers premium price. Grouper and snapper had a positive outlook because high demand of high-quality fish in the international market. Keywords: Leading commodity; financial analysis; aquaculture; Pidie Jaya Abstrak. Komoditas kakap (Lates calcarifer, kerapu (Epinephelus coioides,udang windu (Penaeus monodon, udang vannamei (Litopenaeus vannamei dan nila (Oreochromis niloticus adalah komoditas unggulan yang layak dibudidaya di Kabupaten Pidie Jaya. Bandar Baru dan Tringgadeng merupakan kawasan yang layak untuk pengembangan komoditas udang windu sedangkan Jangka Buya dan Ulim layak untuk pengembangan komoditas udang vannamei. Analisis AHP menunjukkan komoditas udang windu menjadi prioritas utama untuk dikembangkan berdasarkan nilai ekonomi sedangkan udang vannamei menjadi prioritas utama berdasarkan keberlanjutan usaha. Analisis indikator keuangan budidaya kakap, kerapu, udang windu, vannamei dan nila menunjukkan usaha budidaya komoditas unggulan menghasilkan arus kas kumulatif dan NPV positif, nilai  IRR diatas 100%, rasio keuntungan

  3. LA COMUNICAZIONE POLITICA SUI SOCIAL NETWORK: UN’ANALISI LINGUISTICA

    Directory of Open Access Journals (Sweden)

    Daniele Spoladore

    2014-07-01

    Full Text Available Questo lavoro si propone di analizzare le scelte linguistiche dei soggetti politici che utilizzano Facebook e Twitter per rivolgersi al sempre più frammentato panorama dei potenziali elettori. In particolare, analizza le tendenze linguistiche comuni che questi social network hanno fatto emergere nel rapporto tra politica, web e lettori. Cominciando dall’analisi della presenza di parlamentari e senatori su Facebook e Twitter, si cerca di riassumere le principali caratteristiche delle due piattaforme, per giungere ad una classificazione dei testi prodotti attraverso di esse; si analizza la scrittura di post e tweet, sottolineando la presenza di espedienti tipici del mezzo e valutando il loro effetto sui lettori, e si studiano le scelte sintattiche e morfosintattiche in relazione alla struttura e alle possibilità dei due social network. In ultima analisi si osservano le scelte lessicali dei soggetti politici, studiandone i campi semantici e la quantità di tecnicismi. Infine, si cerca di compiere una valutazione delle due differenti tipologie di trasmesso scritto rinvenute nei campioni, osservando come ognuna di esse abbia uno scopo ben preciso nell’economia della comunicazione politica sui social network. Political communication policy in social networks: a language analysis  Daniele Spoladore This paper aims to analyze the linguistic choices of politicians who use Facebook and Twitter to address the increasingly fragmented landscape of potential voters. In particular, it analyzes the common language trends that these social networks have revealed in the relationship between politics, the web and readers. Starting from the analysis of the presence of MPs and senators on Facebook and Twitter, we try to summarize the key features of the two platforms, in order to arrive at a classification of the texts produced using them.  We analyzed posts and tweets, emphasizing the  typical characteristics of these means and evaluating their effect on

  4. Analisis Kinerja Operasional Kereta Api Sriwedari Ekspress Jurusan Solo - Yogya

    Directory of Open Access Journals (Sweden)

    Bayu Rosida Sumantri

    2014-03-01

    Full Text Available Pada bulan Nopember 2012 PT. Kereta Api Indonesia (Persero DAOP 6 Yogyakarta mengoperasikan Kereta Api Sriwedari Ekspress dengan rute perjalanan Yogya – Solo, hal ini dilakukan untuk mengantisipasi lonjakan penumpang akibat pemangkasan rute perjalanan Kereta Api Prambanan Ekspress dari tiga belas kali perjalanan menjadi enam kali perjalanan. Menurut Humas PT. Kereta Api Indonesia (Persero DAOP 6 Yogyakarta, dibukanya rute baru Kereta Api Sriwedari Ekspress yang melayani delapan kali perjalanan hanya  dengan rute Yogya – Solo saja diharapkan kereta ini dapat memfasilitasi pergerakan penumpang antar dua daerah tersebut. Namun untuk mengetahui kinerja dari kereta api ini sesuai dengan Surat Keterangan Dirjen Perhubungan Darat No. 687 Tahun 2002, perlu ditinjau dari segi faktor muat, jumlah penumpang yang diangkut, waktu tunggu penumpang, ketepatan waktu kedatangan dan keberangkatan kereta dan kenyamanan penumpang. Dalam penelitian digunakan metode survey untuk mendapatkan nilai – nilai dari kinerja kereta api Sriwedari berupa survey observasi atau pengamatan lapangan.  Adapun  analisis yang digunakan untuk perhitungan waktu tempuh, waktu henti dan waktu tunda menggunakan uji hipotesis 1 sample t-test, karena uji ini paling memenuhi untuk melihat diterima atau tidaknya keterlambatan dari waktu kereta. Sedangkan untuk perhitungan load factor dan kenyamanan duduk dan berdiri berdasarkan perhitungan kapasitas dari Vukan R. Vuchic. Dari hasil analisis didapatkan waktu tempuh rata-rata untuk arah Yogyakarta selama 1 jam 14 menit dan untuk arah Solo selama 1 jam 12 menit. Waktu henti yang didapat dari seluruh jadwal perjalanan kereta arah Yogyakarta sebesar 3 menit, untuk arah Solo sebesar 5 menit. Waktu tunda dari seluruh perjalanan kereta Api Sriwedari untuk arah Yogyakarta didapat nilai waktu tunda kedatangan sebesar 22 menit dan nilai waktu tunda keberangkatan sebesar 20 menit, untuk arah Solo didapat nilai waktu tunda kedatangan sebesar 34

  5. Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders.

    OpenAIRE

    Bitterman, P B; Adelberg, S; Crystal, R G

    1983-01-01

    Interstitial lung disorders are characterized both by a chronic inflammation of the lower respiratory tract that includes increased numbers of activated alveolar macrophages and by increased numbers of fibroblasts within the alveolar wall. Since alveolar macrophages from normal individuals can be activated to release a growth factor for lung fibroblasts (alveolar macrophage-derived growth factor [AMDGF]), we hypothesized that the activated alveolar macrophages within the lower respiratory tra...

  6. Diffuse alveolar hemorrhage resulting from Pauci-immune pulmonary capillaritis

    Directory of Open Access Journals (Sweden)

    Andreia Salarini Monteiro

    2003-08-01

    Full Text Available A 27 year-old female patient, cocaine user, presenting hemoptysis and progressive dyspnea with onset 48 hours prior to hospital admission, without any other signs or symptoms. Serum tests for infectious diseases, collagen disorders and vasculitis were negative. Urinalysis was normal. Computed tomography of the chest showed diffuse alveolar infiltrate, affecting mainly the lower left lobe. A thoracoscopic lung biopsy was performed to clarify the diagnosis. The histopathological findings showed capillaritis and diffuse intra-alveolar hemorrhage. Treated with steroid and cyclophosphamide pulse therapy, a good clinical and radiographical response was obtained. The recently described pauci-immune pulmonary capillaritis is characterized by the presence of isolated pulmonary capillaritis and negative serum testing for auto-immune diseases.

  7. Alveolar damage in AIDS-related Pneumocystis carinii pneumonia

    DEFF Research Database (Denmark)

    Benfield, T L; Prentø, P; Junge, Jette;

    1997-01-01

    biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases. DESIGN AND PATIENTS: Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy. RESULTS: P carinii pneumonia was characterized by an increase in inflammation, edema......, exudate, fibrosts, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients...... with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p type II pneumocyte was not observed. CONCLUSION: Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form...

  8. Alveolar bone loss in osteoporosis: a loaded and cellular affair?

    Science.gov (United States)

    Jonasson, Grethe; Rythén, Marianne

    2016-01-01

    Maxillary and mandibular bone mirror skeletal bone conditions. Bone remodeling happens at endosteal surfaces where the osteoclasts and osteoblasts are situated. More surfaces means more cells and remodeling. The bone turnover rate in the mandibular alveolar process is probably the fastest in the body; thus, the first signs of osteoporosis may be revealed here. Hormones, osteoporosis, and aging influence the alveolar process and the skeletal bones similarly, but differences in loading between loaded, half-loaded, and unloaded bones are important to consider. Bone mass is redistributed from one location to another where strength is needed. A sparse trabeculation in the mandibular premolar region (large intertrabecular spaces and thin trabeculae) is a reliable sign of osteopenia and a high skeletal fracture risk. Having dense trabeculation (small intertrabecular spaces and well-mineralized trabeculae) is generally advantageous to the individual because of the low fracture risk, but may imply some problems for the clinician.

  9. Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure

    Directory of Open Access Journals (Sweden)

    Ryan R. Kroll

    2016-01-01

    Full Text Available Pulmonary alveolar proteinosis (PAP is a rare condition characterized by dysfunctional alveolar macrophages, which ineffectively clear surfactant and typically cause mild hypoxemia. Characteristic Computed Tomography findings are septal reticulations superimposed on ground-glass opacities in a crazy paving pattern, with a clear juxtaposition between affected and unaffected parenchyma. While traditionally PAP was diagnosed via biopsy, bronchoalveolar lavage (BAL is usually sufficient; the fluid appears milky, and on microscopic examination there are foamy macrophages with eosinophilic granules and extracellular hyaline material that is Periodic Acid-Schiff positive. Standard therapy is whole lung lavage (WLL, although novel treatments are under development. The case presented is a 55-year-old woman with six months of progressive dyspnea, who developed hypoxemic respiratory failure requiring mechanical ventilation; she had typical findings of PAP on imaging and BAL. WLL was ultimately successful in restoring adequate oxygenation. Respiratory failure of this magnitude is a rare finding in PAP.

  10. Cytokinetic study of alveolar macrophage renewal in rats

    International Nuclear Information System (INIS)

    Pools of alveolar macrophages and monocytes were measured by combining morphometry and the extraction of cells by lavage. The turnover rate of macrophages was evaluated by measuring the clearance rate of 59Fe2O3 previously administered by aerosols. The labeling index and S phase duration of cells in alveoli and lung capillaries were determined by autoradiography after 3H-labeled thymidine and 5-125Iododeoxyuridine incorporation. The disappearance rate was determined after specific incorporation of 125Iododeoxyuridine in deoxyribonuclease (DNA) of alveolar macrophages. Steady-state parameters are presented. Under healthy conditions there are almost no macrophages in the interstitium space. Lung capillaries must be considered as a maturation compartment for macrophages before the last dividing stage in the alveoli. This is consistent with the large enrichment of monocytes in the lung and the ability of some of these monocytes to divide inside the capillaries

  11. Alveolar bone loss in osteoporosis: a loaded and cellular affair?

    Science.gov (United States)

    Jonasson, Grethe; Rythén, Marianne

    2016-01-01

    Maxillary and mandibular bone mirror skeletal bone conditions. Bone remodeling happens at endosteal surfaces where the osteoclasts and osteoblasts are situated. More surfaces means more cells and remodeling. The bone turnover rate in the mandibular alveolar process is probably the fastest in the body; thus, the first signs of osteoporosis may be revealed here. Hormones, osteoporosis, and aging influence the alveolar process and the skeletal bones similarly, but differences in loading between loaded, half-loaded, and unloaded bones are important to consider. Bone mass is redistributed from one location to another where strength is needed. A sparse trabeculation in the mandibular premolar region (large intertrabecular spaces and thin trabeculae) is a reliable sign of osteopenia and a high skeletal fracture risk. Having dense trabeculation (small intertrabecular spaces and well-mineralized trabeculae) is generally advantageous to the individual because of the low fracture risk, but may imply some problems for the clinician. PMID:27471408

  12. Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury

    Directory of Open Access Journals (Sweden)

    Reyes Livia

    2005-06-01

    Full Text Available Abstract Background Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate-liposomes in order to study the role of these effector cells in the early endotoxin-induced lung injury. Methods Lipopolysaccharide was applied intratracheally and the inflammatory reaction was assessed 4 hours later. Neutrophil accumulation and expression of inflammatory mediators were determined. To further analyze in vivo observations, in vitro experiments with alveolar epithelial cells and alveolar macrophages were performed. Results A 320% increase of polymorphonuclear leukocytes in bronchoalveolar lavage fluid was observed in macrophage-depleted compared to macrophage-competent lipopolysaccharide-animals. This neutrophil recruitment was also confirmed in the interstitial space. Monocyte chemoattractant protein-1 concentration in bronchoalveolar lavage fluid was significantly increased in the absence of alveolar macrophages. This phenomenon was underlined by in vitro experiments with alveolar epithelial cells and alveolar macrophages. Neutralizing monocyte chemoattractant protein-1 in the airways diminished neutrophil accumulation. Conclusion These data suggest that alveolar macorphages play an important role in early endotoxin-induced lung injury. They prevent neutrophil influx by controlling monocyte chemoattractant protein-1 production through alveolar epithelial cells. Alveolar macrophages might therefore possess robust anti-inflammatory effects.

  13. An automatic early stage alveolar-bone-resorption evaluation method on digital dental panoramic radiographs

    Science.gov (United States)

    Zhang, Min; Katsumata, Akitoshi; Muramatsu, Chisako; Hara, Takeshi; Suzuki, Hiroki; Fujita, Hiroshi

    2014-03-01

    Periodontal disease is a kind of typical dental diseases, which affects many adults. The presence of alveolar bone resorption, which can be observed from dental panoramic radiographs, is one of the most important signs of the progression of periodontal disease. Automatically evaluating alveolar-bone resorption is of important clinic meaning in dental radiology. The purpose of this study was to propose a novel system for automated alveolar-bone-resorption evaluation from digital dental panoramic radiographs for the first time. The proposed system enables visualization and quantitative evaluation of alveolar bone resorption degree surrounding the teeth. It has the following procedures: (1) pre-processing for a test image; (2) detection of tooth root apices with Gabor filter and curve fitting for the root apex line; (3) detection of features related with alveolar bone by using image phase congruency map and template matching and curving fitting for the alveolar line; (4) detection of occlusion line with selected Gabor filter; (5) finally, evaluation of the quantitative alveolar-bone-resorption degree in the area surrounding teeth by simply computing the average ratio of the height of the alveolar bone and the height of the teeth. The proposed scheme was applied to 30 patient cases of digital panoramic radiographs, with alveolar bone resorption of different stages. Our initial trial on these test cases indicates that the quantitative evaluation results are correlated with the alveolar-boneresorption degree, although the performance still needs further improvement. Therefore it has potential clinical practicability.

  14. Injury of the Inferior Alveolar Nerve during Implant Placement: a Literature Review

    Directory of Open Access Journals (Sweden)

    Gintaras Juodzbalys

    2011-01-01

    Full Text Available Objectives: The purpose of present article was to review aetiological factors, mechanism, clinical symptoms, and diagnostic methods as well as to create treatment guidelines for the management of inferior alveolar nerve injury during dental implant placement.Material and Methods: Literature was selected through a search of PubMed, Embase and Cochrane electronic databases. The keywords used for search were inferior alveolar nerve injury, inferior alveolar nerve injuries, inferior alveolar nerve injury implant, inferior alveolar nerve damage, inferior alveolar nerve paresthesia and inferior alveolar nerve repair. The search was restricted to English language articles, published from 1972 to November 2010. Additionally, a manual search in the major anatomy, dental implant, periodontal and oral surgery journals and books were performed. The publications there selected by including clinical, human anatomy and physiology studies.Results: In total 136 literature sources were obtained and reviewed. Aetiological factors of inferior alveolar nerve injury, risk factors, mechanism, clinical sensory nerve examination methods, clinical symptoms and treatment were discussed. Guidelines were created to illustrate the methods used to prevent and manage inferior alveolar nerve injury before or after dental implant placement.Conclusions: The damage of inferior alveolar nerve during the dental implant placement can be a serious complication. Clinician should recognise and exclude aetiological factors leading to nerve injury. Proper presurgery planning, timely diagnosis and treatment are the key to avoid nerve sensory disturbances management.

  15. Oxidative Stress, Cell Death, and Other Damage to Alveolar Epithelial Cells Induced by Cigarette Smoke

    Directory of Open Access Journals (Sweden)

    Nagai A

    2003-09-01

    Full Text Available Abstract Cigarette smoking is a major risk factor in the development of various lung diseases, including pulmonary emphysema, pulmonary fibrosis, and lung cancer. The mechanisms of these diseases include alterations in alveolar epithelial cells, which are essential in the maintenance of normal alveolar architecture and function. Following cigarette smoking, alterations in alveolar epithelial cells induce an increase in epithelial permeability, a decrease in surfactant production, the inappropriate production of inflammatory cytokines and growth factors, and an increased risk of lung cancer. However, the most deleterious effect of cigarette smoke on alveolar epithelial cells is cell death, i.e., either apoptosis or necrosis depending on the magnitude of cigarette smoke exposure. Cell death induced by cigarette smoke exposure can largely be accounted for by an enhancement in oxidative stress. In fact, cigarette smoke contains and generates many reactive oxygen species that damage alveolar epithelial cells. Whether apoptosis and/or necrosis in alveolar epithelial cells is enhanced in healthy cigarette smokers is presently unclear. However, recent evidence indicates that the apoptosis of alveolar epithelial cells and alveolar endothelial cells is involved in the pathogenesis of pulmonary emphysema, an important cigarette smoke-induced lung disease characterized by the loss of alveolar structures. This review will discuss oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke.

  16. Secondary Alveolar Bone Grafting (CLEFTSiS) 2007-2010.

    Science.gov (United States)

    Paterson, Michael; Rae, Jennifer; Paterson, Paul; Gilgrass, Toby; Devlin, Mark; McIntyre, Grant

    2016-03-01

    Objective To determine whether alveolar bone graft outcomes for unilateral and bilateral cleft lip and palate patients have continued to improve since the reorganization of cleft services in Scotland in 2000. Design Retrospective analysis of postoperative anterior occlusal radiographs. Patients and Participants Eighty-one of 106 patients who were eligible for alveolar bone grafting between 2007 and 2010 had suitable postoperative radiographs available. Interventions Twenty-seven percent of the patients (n = 22) had presurgical orthodontic intervention. All patients underwent alveolar bone grafting with bone harvested from the iliac crest. Main Outcome Measures The Kindelan bone-fill index was used to evaluate success. Weighted kappa statistics were used to assess intra- and interobserver reproducibility. A comparison was made with results from 2000 to 2004 to assess any improvement. Chi-square tests (or Fisher exact test) were used to determine whether outcomes differed depending on the laterality of the cleft, use of presurgical expansion, or age at bone grafting. Results Interobserver scoring agreement was good (weighted kappa = .383). Intraobserver reproducibility was greater (weighted kappas of .835 and .620). Success was achieved in 99% of bone grafts, compared with 76% in the period from 2000 to 2004 (P < .001). There was no statistically significant relationship between the laterality of the cleft (P = 1.000), use of presurgical expansion (P = 1.000), or age at time of bone grafting and outcome (P = .259). Conclusion Scottish secondary alveolar bone graft outcomes improved during 2007 to 2010 in comparison to the 2000 to 2004 results. PMID:26914161

  17. Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions.

    Science.gov (United States)

    Intini, G; Katsuragi, Y; Kirkwood, K L; Yang, S

    2014-05-01

    This article reviews recent research into mechanisms underlying bone resorption and highlights avenues of investigation that may generate new therapies to combat alveolar bone loss in periodontitis. Several proteins, signaling pathways, stem cells, and dietary supplements are discussed as they relate to periodontal bone loss and regeneration. RGS12 is a crucial protein that mediates osteoclastogenesis and bone destruction, and a potential therapeutic target. RGS12 likely regulates osteoclast differentiation through regulating calcium influx to control the calcium oscillation-NFATc1 pathway. A working model for RGS10 and RGS12 in the regulation of Ca(2+) oscillations during osteoclast differentiation is proposed. Initiation of inflammation depends on host cell-microbe interactions, including the p38 mitogen-activated protein kinase (MAPK) signaling pathway. Oral p38 inhibitors reduced lipopolysaccharide (LPS)-induced bone destruction in a rat periodontitis model but showed unsatisfactory safety profiles. The p38 substrate MK2 is a more specific therapeutic target with potentially superior tolerability. Furthermore, MKP-1 shows anti-inflammatory activity, reducing inflammatory cytokine biosynthesis and bone resorption. Multipotent skeletal stem cell (SSC) populations exist within the bone marrow and periosteum of long bones. These bone-marrow-derived SSCs and periosteum-derived SSCs have shown therapeutic potential in several applications, including bone and periodontal regeneration. The existence of craniofacial bone-specific SSCs is suggested based on existing studies. The effects of calcium, vitamin D, and soy isoflavone supplementation on alveolar and skeletal bone loss in post-menopausal women were investigated. Supplementation resulted in stabilization of forearm bone mass density and a reduced rate of alveolar bone loss over 1 yr, compared with placebo. Periodontal attachment levels were also well-maintained and alveolar bone loss suppressed during 24 wk of

  18. Coronectomy - A viable alternative to prevent inferior alveolar nerve injury

    Directory of Open Access Journals (Sweden)

    Alok Sagtani

    2015-12-01

    Full Text Available Background and Objectives: Coronectomy is a relatively new method to prevent the risk of Inferior Alveolar Nerve (IAN injury during removal of lower third molars with limited scientific literature among Nepalese patients. Thus, a study was designed to evaluate coronectomy regarding its use, outcomes and complications.Materials and Methods: A descriptive study was conducted from December 2012 to December 2013 among patients attending Department of Oral and Maxillofacial Surgery, College of Dental Sciences, BP Koirala Institute of Health Sciences, Dharan, Nepal for removal of mandibular third molars. After reviewing the radiograph for proximity of third molar to the IAN, coronectomy was advised. A written informed consent was obtained from the patients and coronectomy was performed. Patients were recalled after one week. The outcome measures in the follow-up visit were primary healing, pain, infection, dry socket, root exposure and IAN injury. The prevalence of IAN proximity of lower third molars and incidence of complications were calculated.Results: A total 300 mandibular third molars were extracted in 278 patients during the study period. Out of 300 impacted mandibular third molar, 41 (13.7% showed close proximity to inferior alveolar nerve . The incidence of complications and failed procedure was 7.4% among the patients who underwent coronectomy. During the follow up visit, persistent pain and root exposure was reported while other complications like inferior alveolar nerve injury, dry socket and infection was not experienced by the study patients.Conclusion: With a success rate of 92.6% among the 41 patients, coronectomy is a viable alternative to conventional total extraction for mandibular third molars who have a higher risk for damage to the inferior alveolar nerve.JCMS Nepal. 2015;11(3:1-5.

  19. Myelinated axon counts of human inferior alveolar nerves.

    OpenAIRE

    Heasman, P A; Beynon, A D

    1987-01-01

    A quantitative, postmortem study of 36 human inferior alveolar nerves is described. The total myelinated fibre count (TMFC) of nerves was not related to sex or age of the subjects but significant positive correlations were found between TMFC and subject body weight in both dentate (r = 0.616) and edentulous (r = 0.676) groups. The TMFC was significantly lower in nerves from edentulous subjects than in nerves from dentate subjects.

  20. Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions.

    Science.gov (United States)

    Intini, G; Katsuragi, Y; Kirkwood, K L; Yang, S

    2014-05-01

    This article reviews recent research into mechanisms underlying bone resorption and highlights avenues of investigation that may generate new therapies to combat alveolar bone loss in periodontitis. Several proteins, signaling pathways, stem cells, and dietary supplements are discussed as they relate to periodontal bone loss and regeneration. RGS12 is a crucial protein that mediates osteoclastogenesis and bone destruction, and a potential therapeutic target. RGS12 likely regulates osteoclast differentiation through regulating calcium influx to control the calcium oscillation-NFATc1 pathway. A working model for RGS10 and RGS12 in the regulation of Ca(2+) oscillations during osteoclast differentiation is proposed. Initiation of inflammation depends on host cell-microbe interactions, including the p38 mitogen-activated protein kinase (MAPK) signaling pathway. Oral p38 inhibitors reduced lipopolysaccharide (LPS)-induced bone destruction in a rat periodontitis model but showed unsatisfactory safety profiles. The p38 substrate MK2 is a more specific therapeutic target with potentially superior tolerability. Furthermore, MKP-1 shows anti-inflammatory activity, reducing inflammatory cytokine biosynthesis and bone resorption. Multipotent skeletal stem cell (SSC) populations exist within the bone marrow and periosteum of long bones. These bone-marrow-derived SSCs and periosteum-derived SSCs have shown therapeutic potential in several applications, including bone and periodontal regeneration. The existence of craniofacial bone-specific SSCs is suggested based on existing studies. The effects of calcium, vitamin D, and soy isoflavone supplementation on alveolar and skeletal bone loss in post-menopausal women were investigated. Supplementation resulted in stabilization of forearm bone mass density and a reduced rate of alveolar bone loss over 1 yr, compared with placebo. Periodontal attachment levels were also well-maintained and alveolar bone loss suppressed during 24 wk of

  1. Virulent Coxiella burnetii Pathotypes Productively Infect Primary Human Alveolar Macrophages

    OpenAIRE

    Graham, Joseph G.; MacDonald, Laura J.; Hussain, S. Kauser; Sharma, Uma M.; Kurten, Richard C.; Voth, Daniel E.

    2013-01-01

    The intracellular bacterial pathogen Coxiella burnetii is a category B select agent that causes human Q fever. In vivo, C. burnetii targets alveolar macrophages wherein the pathogen replicates in a lysosome-like parasitophorous vacuole (PV). In vitro, C. burnetii infects a variety of cultured cell lines that have collectively been used to model the pathogen’s infectious cycle. However, differences in the cellular response to infection have been observed, and virulent C. burnetii isolate infec...

  2. Pulmonary alveolar proteinosis in children: a case series

    OpenAIRE

    Seyyed Ahmad Tabatabaei; Abdollah Karimi; Sedigheh Rafiee Tabatabaei; Badiozzaman Radpay; Farzaneh Jadali; Farideh Shiva; Mana Hadipour Jahromy

    2010-01-01

    Pulmonary alveolar proteinosis, (PAP) is a rare disease of unknown etiology, characterized by accumulation of intraalveolar proteinaceous material which is rich in lipid and positive on periodic acid-Schiff stain. Two clinically different pediatric types have been defined as congenital PAP which is fulminant and fatal, and a late-onset PAP which is similar to the adult form and less severe. Eight children with late-onset PAP were hospitalized from 1998 to 2005 in Mofid Children Hospital. Char...

  3. Accumulation of surfactant protein D in human pulmonary alveolar proteinosis.

    OpenAIRE

    Crouch, E; Persson, A.; Chang, D.

    1993-01-01

    Surfactant protein D (SP-D) is a collagenous calcium-dependent carbohydrate-binding protein that is structurally related to the serum mannose-binding proteins and pulmonary surfactant protein A. SP-D was initially characterized as a biosynthetic product of freshly isolated rat type II cells and first purified in chemical amounts from bronchoalveolar lavage of rats with silica-induced alveolar lipoproteinosis. The present studies describe the characterization of human SP-D isolated from therap...

  4. Pulmonary Alveolar Proteinosis in Workers at an Indium Processing Facility

    OpenAIRE

    Cummings, Kristin J.; Donat, Walter E.; Ettensohn, David B; Roggli, Victor L; Ingram, Peter; Kreiss, Kathleen

    2009-01-01

    Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage–colonystimulating factor (GM-CSF) and found to have an elevated level. These cases suggest that inhalational exposure to ITO causes pulmonary alveol...

  5. Nocardial brain abscess in a patient with pulmonary alveolar proteinosis

    OpenAIRE

    Shirani, Kiana; Poulsen, Asger Nyborg; Hakamifard, Atousa

    2015-01-01

    Brain abscesses caused by Nocardia are rare but have a very high mortality and specific requirements of antibiotic treatment. Nocardial brain abscesses are mainly found in patients with predisposing conditions such as pulmonary alveolar proteinosis (PAP), a disease associated with chronic exposure to silica dust. We present a case of multiple nocardial brain abscesses in a man with PAP probably due to long-term occupational exposure to silica dust. Conclusively, in patients presenting brain a...

  6. Alveolar proteinosis: diagnosis and treatment over a 10-year period.

    OpenAIRE

    du Bois, R M; McAllister, W A; Branthwaite, M A

    1983-01-01

    Ten years' experience of using bronchoalveolar lavage in the treatment of 10 patients with alveolar proteinosis is reported. The diagnosis was often missed. The interval between onset of symptoms and diagnosis varied from six weeks to six years (median 2 years), so that the start of treatment was often delayed. Some patients experienced severe progressive disability before they had treatment. Whole-lung lavage proved to be a safe, repeatable procedure which provided symptomatic, physiological...

  7. Endogenous lipoid pneumonia preceding diagnosis of pulmonary alveolar proteinosis.

    Science.gov (United States)

    Antoon, James W; Hernandez, Michelle L; Roehrs, Phillip A; Noah, Terry L; Leigh, Margaret W; Byerley, Julie S

    2016-03-01

    Pulmonary alveolar proteinosis (PAP) is an under-reported and under-diagnosed condition, with a high percentage of cases found on autopsy or late stage disease. The etiology of PAP includes genetic, primary (anti-granulocyte-macrophage colony-stimulating factor antibodies) and secondary (oncologic, rheumatologic, infectious, chemical and immunologic) causes. Here, we present the first reported pediatric case of endogenous lipoid pneumonia and non-specific interstitial pneumonitis preceding the development of PAP. PMID:25103284

  8. Acute pulmonary alveolar proteinosis due to exposure to cotton dust

    OpenAIRE

    Thind Gurcharan

    2009-01-01

    Secondary pulmonary alveolar proteinosis (PAP) is rare but may occur in association with malignancy, certain infections, and exposure to inorganic or organic dust and some toxic fumes. This case report describes the second recorded case of PAP due to exposure to cotton dust. A 24-year-old man developed PAP after working as a spinner for eight years without respiratory protection. He was admitted as an emergency patient with very severe dyspnea for four months and cough for several years. Ches...

  9. Cell mechanics of alveolar epithelial cells (AECs) and macrophages (AMs).

    OpenAIRE

    Féréol, Sophie; Fodil, Redouane; Pelle, Gabriel; Louis, Bruno; Isabey, Daniel

    2008-01-01

    Cell mechanics provides an integrated view of many biological phenomena which are intimately related to cell structure and function. Because breathing constitutes a sustained motion synonymous with life, pulmonary cells are normally designed to support permanent cyclic stretch without breaking, while receiving mechanical cues from their environment. The authors study the mechanical responses of alveolar cells, namely epithelial cells and macrophages, exposed to well-controlled mechanical stre...

  10. Biomimetics of fetal alveolar flow phenomena using microfluidics

    OpenAIRE

    Tenenbaum-Katan, Janna; Fishler, Rami; Rothen-Rutishauser, Barbara; Sznitman, Josué

    2015-01-01

    At the onset of life in utero, the respiratory system begins as a liquid-filled tubular organ and undergoes significant morphological changes during fetal development towards establishing a respiratory organ optimized for gas exchange. As airspace morphology evolves, respiratory alveolar flows have been hypothesized to exhibit evolving flow patterns. In the present study, we have investigated flow topologies during increasing phases of embryonic life within an anatomically inspired microfluid...

  11. Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

    OpenAIRE

    Whitsett, Jeffrey A.; Wert, Susan E.; Weaver, Timothy E.

    2010-01-01

    The alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Maintenance of pulmonary function depends on the function of type II epithelial cells that synthesize and secrete pulmonary surfactant lipids and proteins, reducing the collapsing forces created at the air-liquid interface in the alveoli. Genetic and acquired disorders associated with the surfactant system cause both acute and ch...

  12. Alveolar Ridge Augmentation with Titanium Mesh. A Retrospective Clinical Study

    OpenAIRE

    Poli, Pier P; Beretta, Mario; Cicciù, Marco; Maiorana, Carlo

    2014-01-01

    An adequate amount of bone all around the implant surface is essential in order to obtain long-term success of implant restoration. Several techniques have been described to augment alveolar bone volume in critical clinical situations, including guided bone regeneration, based on the use of barrier membranes to prevent ingrowth of the epithelial and gingival connective tissue cells. To achieve this goal, the use of barriers made of titanium micromesh has been advocated. A total of 13 patients...

  13. The Application of Fishbone Diagram Analisis to Improve School Quality

    Directory of Open Access Journals (Sweden)

    Slameto Slameto

    2016-06-01

    Full Text Available The research problems are: 1 What steps are to take in a program development aimed at improving the quality of school using a fishbone analysis? 2 Is the program model using fishbone analysis  effective and efficient in meeting the school’s needs to improve its quality? This is research and developmental which comprises 3 phases, namely Preliminary Study, Model Development, and Evaluation/Model Testing. The qualitative data come from the input of management experts and the result of interviews/FGD with stakeholders. The quantitative data are obtained from the assessment of management experts on the product draft, the observation sheets for the field study on the standards of education, and the try out. Data analisis on the validation result uses a descriptive analysis technique. Data from the questionnaire are analyzed by descriptive statistical technique. The results are: 1 the developmental steps in the school quality improvement program by way of fish bone analysis have gone through 6 phases, 2 the research product using fish bone diagram has proved to be simple, applicable, important, controllable, as well as adaptable. Furthermore, it is communicable, so that it has been effective and efficient in meeting the school’s needs for making its educational quality improved.

  14. ANALISIS TINGKAT PENDAPATAN PEDAGANG CANANG DI PASAR BADUNG

    Directory of Open Access Journals (Sweden)

    Surya Dewi Rustariyuni

    2015-12-01

    Full Text Available This studyanalyzes thecharacteristic of “canang”sellers, their economicactivities, their revenues, the factors which influencethem to chooseBadung Market for selling their products and theircontributions in their household economy. As a matter of fact,all of Hindu ismpeoplein Bali use canang everyday for conductingall ceremonies, but only few people whomake canang. It has occured foryears. The method used for analizing the data isdescriptive analysis. The result shows thatthe canang sellersare mostlyfrom Bali. They are dominated by married women atthe age of 15 up to 35 years old. Then, theireducational backgroundaresenior high schools. They start selling early in the morning and stop their activities in the evening.Finally, usually the sellers get much money when there is a big ceremony.Penelitian ini menganalisis karakteristik penjual "canang", kegiatan ekonominya, pendapatannya, faktor-faktor yang mempengaruhi penjual canang untuk memilih Pasar Badung sebagai tempat untuk menjual canangnya dan kontribusi penjual canang dalam perekonomian rumah tangga. Sebenarnya, semua orang Hindu di Bali menggunakan canang setiap hari untuk melakukan semua upacara, tetapi hanya sedikit orang yang membuat canang. Ini telah terjadi selama bertahun-tahun. Metode yang digunakan untuk menganalisis data disini adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa para penjual canang sebagian besar dari Bali. Mereka didominasi oleh perempuan yang sudah menikah danusianya antara 15 hingga 35 tahun. Kemudian, latar belakang pendidikan mereka adalah sekolah menengah atas. Mereka mulai menjual canang di pagi hari dan selesai di malam hari. Biasanya para penjual mendapatkan uang banyak ketika ada upacara besar.

  15. Alveolar echinococcosis of the liver. Findings of magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Hayasaka, Kazumasa; Tanaka, Yoshiaki; Okuhata, Yoshitaka; Yoshinobu, Takashi; Takemoto, Akiko; Himi, Kazuhisa; Mutoh, Haruomi [Nihon Univ., Tokyo (Japan). School of Medicine; Shuke, Noriyuki; Aburano, Tamio

    1995-06-01

    The purpose of the present study was to evaluate the findings of MR imaging obtained in patients with Echinococcus multilocularis involving the liver. For 10 patients with alveolar echinococcosis of the liver, the MR findings were compared with the histopathologic findings after biopsy or surgery. Conventional T1-weighted spin echo, T2-weighted spin echo and T1-weighted spin echo after Gd-DTPA were employed. The signal from the lesions of alveolar liver echinococcosis on T1-weighted images was hypointense in 16 of 23 lesions (69.6%), hyperintense in 4 (17.4%), and isointense in 3 (13.0%). The signal from the lesions on T2-weighted images was hyperintense in 20 lesions (87.0%), hypointense in 2 (8.7%), and isointense in one (4.3%). On using Gd-DTPA, 7 of 21 lesions (33.3%) were observed with rim enhancement, and 14 lesions (66.7%) were non-enhanced. We describe our clinical experience together with the various findings of MR imaging as observed in the patients with alveolar echinococcosis of the liver. MR imaging excels in visualizing a low-intensity rim and small cystic foci, with liquefaction necrotic foci displaying a variety of signal intensities. After Gd-DTPA administration, the surrounding inflammatory granulomatous foci could be more clearly visualized. (author).

  16. Effects of elastase and cigarette smoke on alveolar epithelial permeability

    International Nuclear Information System (INIS)

    To determine whether instilled porcine pancreatic elastase (PPE) increases alveolar epithelial permeability, the authors measured alveolar epithelium permeability X surface area (PS) for [14C]sucrose and 125I-bovine serum albumin in isolated perfused lungs from hamsters previously exposed to PPE and/or cigarette smoke. Saline (0.5 ml) with 0, 5, or 20 units PPE was instilled intratracheally in anesthetized hamsters. Those exposed to smoke for 4-6 wk received 0 or 5 units; PS was measured 3 h later. Nonsmokers received 0, 5, or 20 units; PS was measured 3 h, 24 h, or 5 days later. Control PS values were (cm3/s X 10(-4), +/- SE) 0.84 +/- 0.11 for sucrose and 0.030 +/- 0.006 for BSA. Three and 24 h following 20 units PPE, (PS)sucrose was twice the control valve. (PS)BSA was four times control at 3 h but not significantly increased at 24 h. Five days after PPE both were back to control levels. Five units PPE or smoke exposure alone caused no PS changes. Smoke exposure and 5 units PPE caused (PS)sucrose to increase markedly (1.85 +/- 0.32); (PS)BSA was not significantly increased (0.076 +/- 0.026). Thus, instilled PPE causes reversible increases in alveolar epithelial PS; cigarette smoking potentiates this effect

  17. Quality assessment of systematic reviews on alveolar socket preservation.

    Science.gov (United States)

    Moraschini, V; Barboza, E Dos S P

    2016-09-01

    The aim of this overview was to evaluate and compare the quality of systematic reviews, with or without meta-analysis, that have evaluated studies on techniques or biomaterials used for the preservation of alveolar sockets post tooth extraction in humans. An electronic search was conducted without date restrictions using the Medline/PubMed, Cochrane Library, and Web of Science databases up to April 2015. Eligibility criteria included systematic reviews, with or without meta-analysis, focused on the preservation of post-extraction alveolar sockets in humans. Two independent authors assessed the quality of the included reviews using AMSTAR and the checklist proposed by Glenny et al. in 2003. After the selection process, 12 systematic reviews were included. None of these reviews obtained the maximum score using the quality assessment tools implemented, and the results of the analyses were highly variable. A significant statistical correlation was observed between the scores of the two checklists. A wide structural and methodological variability was observed between the systematic reviews published on the preservation of alveolar sockets post tooth extraction. None of the reviews evaluated obtained the maximum score using the two quality assessment tools implemented. PMID:27061478

  18. Diffuse alveolar hemorrhage in isolated pulmonary capillaritis: Case report

    Directory of Open Access Journals (Sweden)

    Medenica Milić

    2014-01-01

    Full Text Available Introduction. Pulmonary capillaritis is a small-diameter vessel vasculitis of the lung, which may occur in isolation as in isolated pauci-immune capillaritis, usually associated with the systemic vasculitis but it could be also related to collagen vascular diseases and in lung transplant rejection. Pulmonary capillaritis leads to diffuse alveolar hemorrhage. The clinical presentation includes symptoms like dyspnea, cough, pleuritic chest pain, fever and hemoptysis. Case Outline. A 48 year-old female patient, smoker, presented with progressive dyspnea. Serum tests for infectious diseases, collagen disorders and vasculitis were negative. Radiography and computed tomography of the chest showed diffuse alveolar infiltrates. Cytology of bronchoalveolar lavage showed presence of siderophages. A thoracoscopic lung biopsy was performed to clarify the diagnosis. The histopathological findings showed capillaritis and diffuse intraalveolar hemorrhage. Patient was treated with steroids, and good clinical and minimal radiographic response was obtained. Recently described pauci-immune pulmonary capillaritis has been characterized as p-ANCA (antineutrophil cytoplasmic antibodies negative isolated pulmonary capillaritis. Conclusion. Isolated pauci-immune pulmonary capillaritis is a rare disease. First clinical manifestations of the isolated pulmonary capillaritis were the symptoms of progressive dyspnea, radiographic and functional signs of the interstitial fibrosis. At the same time, the signs of extrapulmonary diseases were not found. Presence of siderophages in bronchoalveolar lavage indicated alveolar hemorrhage. Histopathological tests of the sample of the lung pointed to pulmonary capillaritis and intraalveolar hemorrhage. Prolonged treatment with corticosteroids was necessary.

  19. Primary alveolar soft-part sarcoma of stomach.

    Science.gov (United States)

    Yagihashi, S; Yagihashi, N; Hase, Y; Nagai, K; Alguacil-Garcia, A

    1991-04-01

    A case of primary gastric alveolar soft-part sarcoma is presented. The tumor was found in the gastric remnant of a 67-year-old male who had undergone partial gastrectomy due to hemorrhagic gastric ulcer 13 years before. It was located mostly in the submucosa arising from the muscularis propria. The large eosinophilic cells showed the characteristic alveolar compartmentalization and contained intracytoplasmic periodic acid-Schiff-positive granules and typical crystals. Numerous electron-opaque secretory granules in the tumor cell cytoplasm, in addition to crystals of 9 nm periodicity, were confirmed at the ultrastructural levels. Immunostaining failed to detect muscle-related antigens. In contrast, methionine-enkephalin and neuropeptide Y appeared positive in the tumor cells. Interstitial spindle cells showed an occasional positivity to S-100. This is the first case of such a tumor occurring in the gastrointestinal tract, and the findings suggest that gastric alveolar soft-part sarcomas may have a different origin from those arising in the skeleton.

  20. Pulmonary Alveolar Proteinosis in Children: A case series

    Directory of Open Access Journals (Sweden)

    seyyed Ahmad Tabatabaei

    2010-01-01

    Full Text Available Pulmonary Alveolar Proteinosis(PAP is a rare disease of unknown etiology, characterized by the accumulation of proteinoceous material in the alveoli that is rich in lipid and is positive on periodic acid-Schiff(PAS stain. PAP is rare in children. Two forms are encountered in pediatric practice: congenital alveolar proteinosis (CAP and a later–onset form that is generally less severe. Broncho-alveolar lavage is the key to diagnosis. Therapeutic lung lavages are the only effective treatment for severe cases. Other therapeutic trials have been proposed such as: lung transplantation, adminstration of GM- CSF and gene-therapy. This case series presents six cases of PAP which were diagnosed by open lung biopsy in Mofid children hospital in Tehran capital city over a three-year period (2003–2006 and one in 1998. The aim of the present study was to provide detailed data on the characteristics of these patients and the methods of diagnosis and treatment.

  1. Alveolar epithelial type II cell: defender of the alveolus revisited

    Directory of Open Access Journals (Sweden)

    Fehrenbach Heinz

    2001-01-01

    Full Text Available Abstract In 1977, Mason and Williams developed the concept of the alveolar epithelial type II (AE2 cell as a defender of the alveolus. It is well known that AE2 cells synthesise, secrete, and recycle all components of the surfactant that regulates alveolar surface tension in mammalian lungs. AE2 cells influence extracellular surfactant transformation by regulating, for example, pH and [Ca2+] of the hypophase. AE2 cells play various roles in alveolar fluid balance, coagulation/fibrinolysis, and host defence. AE2 cells proliferate, differentiate into AE1 cells, and remove apoptotic AE2 cells by phagocytosis, thus contributing to epithelial repair. AE2 cells may act as immunoregulatory cells. AE2 cells interact with resident and mobile cells, either directly by membrane contact or indirectly via cytokines/growth factors and their receptors, thus representing an integrative unit within the alveolus. Although most data support the concept, the controversy about the character of hyperplastic AE2 cells, reported to synthesise profibrotic factors, proscribes drawing a definite conclusion today.

  2. Cinemateca de Vertigo. El delirio de la mirada: Vertigo (1958, Alfred Hitchcock) Analisis de una secuencia

    OpenAIRE

    Castro de Paz, José Luis

    1992-01-01

    Castro De Paz, JL. (1992). Cinemateca de Vertigo. El delirio de la mirada: Vertigo (1958, Alfred Hitchcock) Analisis de una secuencia. Vértigo. Revista de cine. (2):43-48. http://hdl.handle.net/10251/42923. 43 48 2

  3. ANALISIS PENGARUH CORPORATE SOCIAL RESPONSIBILITY TERHADAP CITRA PERUSAHAAN ( STUDI KASUS PT. International Nickel Indonesia Tbk)

    OpenAIRE

    ULVA, -

    2012-01-01

    ULVA. Analisis Pengaruh Corporate Social Responsibility terhadap Citra Perusahaan (Studi Kasus PT. International Nickel Indonesia Tbk), di bawah bimbingan Drs. M. Ishak Amsari, M.Si, Ak dan Drs. Agus Bandang, M.Si, Ak. Kata Kunci : Corporate Social Responsibility, Citra Perusahaan Penelitian ini dilatarbelakangi oleh semakin berkembangnya perusahaan yang juga memunculkan akan kesadaran tanggung jawab sosial perusahaan terhadap lingkungan dan ...

  4. ANALISIS LABELLING PEREMPUAN DENGAN TEORI FEMINISME PSIKOANALISIS: STUDI KASUS MAJALAH REMAJA OLGA!

    OpenAIRE

    - Muashomah

    2013-01-01

    Labelling perempuan dalam majalah remaja merupakan salah satu tindakan media yang merugikan perempuan. Dalam tulisan ini, penulis mengkaji label-label perempuan, bentuk labelling, analisis teori feminisme psikoanalisis terhadap labelling untuk perempuan dalam majalah remaja. Dalam penelitian ini penulis menggunakan metode semiotik dan penelitian dilakukan terhadap majalah Olga. Hasil penelitian menunjukkan bahwa praktek pelabelan terhadap perempuan yang dilakukan oleh majalah remaja ditujukan...

  5. ANALISIS PENGARUH KUALITAS FINANSIAL PERUSAHAAN, KUALITAS AUDITOR DAN KUALITAS PEREKONOMIAN TERHADAP OPINI AUDIT (GOING CONCERN)

    OpenAIRE

    Baqarina Hadori; Bambang Sudibyo

    2014-01-01

    Abstrak: Analisis Pengaruh Kualitas Finansial Perusahaan, Kualitas Auditor, Dan Kualitas Perekonomian Terhadap Opini Audit (Going Concern). Penelitian ini bertujuan untuk menguji pengaruh faktor keuangan dan faktor non-keuangan terhadap pemberian opini audit going concern oleh auditor. Faktor keuangan yang diuji adalah profitabilitas, likuiditas, solvabilitas, pertumbuhan penjualan tahunan, dan pertumbuhan harga saham. Sedangkan faktor non-keuangan yang diuji adalah kualitas auditor dan kuali...

  6. ‘Usi’ e ‘abusi’ nel diritto: Una riflessione critica sulla normativa in materia di analisi genetiche

    Directory of Open Access Journals (Sweden)

    Salardi Silvia

    2013-01-01

    Full Text Available Al centro di questo contributo vi è l’analisi eticogiuridica degli atti normativi disciplinanti le analisi genetiche in vari contesti, ad esempio, ricerca medica, terapia, medicina legale e così dicendo. Lo scopo è di mettere in evidenza i valori ai quali sono state improntate alcune risposte normative. Pertanto, dopo una ricognizione delle varie tipologie di analisi genetiche e dei loro possibili impieghi, il presente lavoro confronta i testi normativi internazionali, europei e nazionali (Austria, Francia, Germania, Svizzera, al fine di individuare la strada percorsa e da percorrere per salvaguardare il più possibile certi valori ritenuti fondamentali per la preservazione sia dell’autonomia individuale, sia dell’eguaglianza tra i consociati. Si concluderà che non tutte le norme che disciplinano le analisi genetiche possono considerarsi rispettose dei diritti fondamentali garantiti a tutti gli individui.

  7. Elemental analysis of lung tissue particles and intracellular iron content of alveolar macrophages in pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    Ohkubo Takeru

    2011-06-01

    Full Text Available Abstract Background Pulmonary alveolar proteinosis (PAP is a rare disease occurred by idiopathic (autoimmune or secondary to particle inhalation. The in-air microparticle induced X-ray emission (in-air micro-PIXE system performs elemental analysis of materials by irradiation with a proton microbeam, and allows visualization of the spatial distribution and quantitation of various elements with very low background noise. The aim of this study was to assess the secondary PAP due to inhalation of harmful particles by employing in-air micro-PIXE analysis for particles and intracellular iron in parafin-embedded lung tissue specimens obtained from a PAP patient comparing with normal lung tissue from a non-PAP patient. The iron inside alveolar macrophages was stained with Berlin blue, and its distribution was compared with that on micro-PIXE images. Results The elements composing particles and their locations in the PAP specimens could be identified by in-air micro-PIXE analysis, with magnesium (Mg, aluminum (Al, silicon (Si, phosphorus (P, sulfur (S, scandium (Sc, potassium (K, calcium (Ca, titanium (Ti, chromium (Cr, copper (Cu, manganase (Mn, iron (Fe, and zinc (Zn being detected. Si was the major component of the particles. Serial sections stained by Berlin blue revealed accumulation of sideromacrophages that had phagocytosed the particles. The intracellular iron content of alveolar macrophage from the surfactant-rich area in PAP was higher than normal lung tissue in control lung by both in-air micro-PIXE analysis and Berlin blue staining. Conclusion The present study demonstrated the efficacy of in-air micro-PIXE for analyzing the distribution and composition of lung particles. The intracellular iron content of single cells was determined by simultaneous two-dimensional and elemental analysis of paraffin-embedded lung tissue sections. The results suggest that secondary PAP is associated with exposure to inhaled particles and accumulation of iron in

  8. Elemental analysis of lung tissue particles and intracellular iron content of alveolar macrophages in pulmonary alveolar proteinosis

    OpenAIRE

    Ohkubo Takeru; Yokoyama Akihito; Koka Masashi; Satoh Takahiro; Yanagitani Noriko; Dobashi Kunio; Matsuzaki Shinichi; Shimizu Yasuo; Ishii Yasuyuki; Kamiya Tomihiro; Mori Masatomo

    2011-01-01

    Abstract Background Pulmonary alveolar proteinosis (PAP) is a rare disease occurred by idiopathic (autoimmune) or secondary to particle inhalation. The in-air microparticle induced X-ray emission (in-air micro-PIXE) system performs elemental analysis of materials by irradiation with a proton microbeam, and allows visualization of the spatial distribution and quantitation of various elements with very low background noise. The aim of this study was to assess the secondary PAP due to inhalation...

  9. Treatment of sharp mandibular alveolar process with hybrid prosthesis

    Directory of Open Access Journals (Sweden)

    Sukaedi Sukaedi

    2010-09-01

    Full Text Available Background: Losing posterior teeth for a long time would occasionally lead to the sharpening of alveolar process. The removable partial denture usually have problems when used during mastication, because of the pressure on the mucosa under the alveolar ridge. Purpose: The purpose of this case report was to manage patients with sharp mandibular alveolar process by wearing hybrid prosthesis with extra coronal precision attachment retention and soft liner on the surface base beneath the removable partial denture. Case: A 76 years old woman visited the Prosthodontic Clinic Faculty of Dentistry Airlangga University. The patient had a long span bridge on the upper jaw and a free end acrylic removable partial denture on the lower jaw. She was having problems with mastication. The patient did not wear her lower denture because of the discomfort with it during mastication. Hence, she would like to replace it with a new removable partial denture. Case management: The patient was treated by wearing a hybrid prosthesis with extra coronal precision attachment on the lower jaw. Soft liner was applied on the surface of the removable partial denture. Hybrid prosthesis is a complex denture consisting of removable partial denture and fixed bridge. Conclusion: It concluded that after restoration, the patient had no problems with sharp alveolar process with her new denture, and she was able to masticate well.Latar belakang: Kehilangan geligi posterior dapat menimbulkan processus alveolaris tajam. Gigi tiruan sebagian lepasan mempunyai masalah selama pengunyahan karena adanya tekanan di mukosa di bawah alveolar ridge. Tujuan: Tujuan laporan kasus ini adalah untuk menjelaskan cara menangani pasien yang mempunyai prosesus alveolaris yang tajam di rahang bawah dengan dibuatkan protesis hybrid dengan daya tahan extra coronal precision attachment dan soft liner di permukaan bawah basis gigi tiruan sebagian lepasan. Kasus: Pasien wanita berumur 76 tahun datang di klinik

  10. The use of digital periapical radiographs to study the prevalence of alveolar domes

    Science.gov (United States)

    Xambre, Pedro Augusto Oliveira Santos; Valerio, Claudia Scigliano; e Alves Cardoso, Claudia Assunção; Custódio, Antônio Luís Neto

    2016-01-01

    Purpose In the present study, we coined the term 'alveolar dome' and aimed to demonstrate the prevalence of alveolar domes through digital periapical radiographs. Materials and Methods This study examined 800 digital periapical radiographs in regard to the presence of alveolar domes. The periapical radiographs were acquired by a digital system using a photostimulable phosphor (PSP) plate. The χ2 test, with a significance level of 5%, was used to compare the prevalence of alveolar domes in the maxillary posterior teeth and, considering the same teeth, to verify the difference in the prevalence of dome-shaped phenomena between the roots. Results The prevalence of alveolar domes present in the first pre-molars was statistically lower as compared to the other maxillary posterior teeth (pauxiliary information necessary to identify alveolar domes, thus improving diagnosis, planning, and treatment. PMID:27672614

  11. Alveolar bone grafting in the treatment of midline alveolar cleft and diastema in incomplete median cleft lip.

    Science.gov (United States)

    Liao, H-T; Chen, C-H; Bergeron, L; Ko, E W-C; Chen, P K T; Chen, Y-R

    2008-10-01

    Median cleft lip is a rare congenital anomaly. The wide diastema with mesial tipping observed in these patients has been largely overlooked. A midline submucosal alveolar cleft prevents adequate treatment. The purpose of this article is to describe an alveolar bone grafting (ABG) technique used in the combined surgical-orthodontic approach to diastema treatment in patients presenting with incomplete median cleft lip. Patients treated for incomplete median cleft lip and diastema were identified in the clinic registry from 1981 to 2007. Six patients were identified; 4 underwent ABG before permanent maxillary incisor eruption, the other 2 were seen later when they were 11 years old. All 6 ABGs were successful. The incisors erupted through the graft or were successfully moved into it with lasting results. Follow-up ranged from 8 to 21 years. The existence of a midline submucosal alveolar cleft and subsequent diastema should be recognized and addressed in all patients who present with incomplete median cleft lip repair. This includes taking maxillary occlusal view X-rays before the age of 5 years to detect the cleft, and proceed to ABG if necessary, generally before permanent maxillary incisor eruption. PMID:18771899

  12. Analisis Faktor-faktor Yang Mempengaruhi Dividend Payout Ratio Pada Industri Barang Konsumsi Di Bursa Efek Indonesia.

    OpenAIRE

    Ketaren, Roby Juahta

    2011-01-01

    Penelitian ini bertujuan untuk menguji dan menganalisis faktor-faktor yang mempengaruhi Dividend Payout Ratio pada industri barang konsumsi di Bursa Efek Indonesia. Pada penelitian ini digunakan analisis fundamental perusahaan melalui analisis rasio keuangan antara lain Cash Position (CP), Debt to Equity Ratio (DER), Return on Assets (ROA), Growth Potential (GP), Firm Size, dan Dividend Payout Ratio (DPR). Periode penelitian dimulai dari tahun 2006-2009. Hipotesis yang dikemukakan adalah Cash...

  13. A Case of Alveolar Echinococcosis Presenting as Cerebral and Spinal Intradural Metastases.

    Science.gov (United States)

    Atalan, Guneri; Sivrioglu, Ali Kemal; Sönmez, Güner; Celik, Mahir; Simsek, Berksan

    2016-06-01

    Alveolar echinococcosis is a chronic and serious, even lethal, parasitic infection caused by the helminth Echinococcus multilocularis. The involvement of Central Nervous System is reported to be 1-3% in literature. Brain involvement is considered a sign of the terminal phase of alveolar echinococcosis. We here in reported a 67-year-old female who had liver alveolar hydatid disease with brain and spinal intradural metastases. PMID:27551181

  14. Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

    OpenAIRE

    Sisson, Thomas H.; Mendez, Michael; Choi, Karen; Subbotina, Natalya; Courey, Anthony; Cunningham, Andrew; Dave, Aditi; Engelhardt, John F.; Liu, Xiaoming; White, Eric S.; Thannickal, Victor J.; Bethany B Moore; Christensen, Paul J; Simon, Richard H

    2009-01-01

    Rationale: Ineffective repair of a damaged alveolar epithelium has been postulated to cause pulmonary fibrosis. In support of this theory, epithelial cell abnormalities, including hyperplasia, apoptosis, and persistent denudation of the alveolar basement membrane, are found in the lungs of humans with idiopathic pulmonary fibrosis and in animal models of fibrotic lung disease. Furthermore, mutations in genes that affect regenerative capacity or that cause injury/apoptosis of type II alveolar ...

  15. The potential of microfluidic lung epithelial wounding: towards in vivo-like alveolar microinjuries

    OpenAIRE

    Felder, Marcel; Stucki, Andreas; Stucki, Janick; Geiser, Thomas; Guenat, Olivier Thierry

    2014-01-01

    Idiopathic pulmonary fibrosis (IPF) remains a major clinical challenge to date. Repeated alveolar epithelial microinjuries are considered as the starting point and the key event in both the development and the progression of IPF. Various pro-fibrotic agents have been identified and shown to cause alveolar damage. In IPF, however, no leading cause of alveolar epithelial microinjuries can be identified and the exact etiology remains elusive. New results from epidemiologic studies suggest a caus...

  16. Oxidative Stress, Cell Death, and Other Damage to Alveolar Epithelial Cells Induced by Cigarette Smoke

    OpenAIRE

    Aoshiba K; Nagai A

    2003-01-01

    Abstract Cigarette smoking is a major risk factor in the development of various lung diseases, including pulmonary emphysema, pulmonary fibrosis, and lung cancer. The mechanisms of these diseases include alterations in alveolar epithelial cells, which are essential in the maintenance of normal alveolar architecture and function. Following cigarette smoking, alterations in alveolar epithelial cells induce an increase in epithelial permeability, a decrease in surfactant production, the inapprop...

  17. Simultaneous occurrence of pulmonary interstitial fibrosis and alveolar cell carcinoma in one family.

    OpenAIRE

    Beaumont, F; Jansen, H. M.; Elema, J D; ten Kate, L P; Sluiter, H J

    1981-01-01

    The coexistence of interstitial pulmonary fibrosis and alveolar cell carcinoma is well known. The familial occurrence of a combination of these two entities, however, is very rare. We present a family of which five members had diffuse interstitial pulmonary fibrosis. Three of them had in addition alveolar cell carcinoma. In a sixth family member, evidence of alveolar cell carcinoma was present without proven interstitial fibrosis. An autosomal dominant trait is suggested as the mode of inheri...

  18. KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome.

    OpenAIRE

    Kida, Yoshiko

    2014-01-01

    Background: Diffuse alveolar hemorrhage syndrome is a life threatening condition with diverse etiologies. Sensitive prognostic markers for diffuse alveolar hemorrhage have not been well investigated. Serum KL-6 is a biomarker for various interstitial lung disease associated with disease activity and prognosis. The purpose of the present study was to evaluate the clinical utility of serum KL-6 level as a prognostic marker for diffuse alveolar hemorrhage. Methods: We retrospectively colle...

  19. KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome

    OpenAIRE

    Kida Yoshiko; Ohshimo Shinichiro; Ota Kohei; Tamura Tomoko; Otani Tadatsugu; Une Kazunobu; Sadamori Takuma; Iwasaki Yasumasa; Bonella Francesco; Hattori Noboru; Hirohashi Nobuyuki; Guzman Josune; Costabel Ulrich; Kohno Nobuoki; Tanigawa Koichi

    2012-01-01

    Abstract Background Diffuse alveolar hemorrhage syndrome is a life threatening condition with diverse etiologies. Sensitive prognostic markers for diffuse alveolar hemorrhage have not been well investigated. Serum KL-6 is a biomarker for various interstitial lung disease associated with disease activity and prognosis. The purpose of the present study was to evaluate the clinical utility of serum KL-6 level as a prognostic marker for diffuse alveolar hemorrhage. Methods We retrospectively coll...

  20. Injury of the Inferior Alveolar Nerve during Implant Placement: a Literature Review

    OpenAIRE

    Gintaras Juodzbalys; Hom-Lay Wang; Gintautas Sabalys

    2011-01-01

    ABSTRACT Objectives The purpose of present article was to review aetiological factors, mechanism, clinical symptoms, and diagnostic methods as well as to create treatment guidelines for the management of inferior alveolar nerve injury during dental implant placement. Material and Methods Literature was selected through a search of PubMed, Embase and Cochrane electronic databases. The keywords used for search were inferior alveolar nerve injury, inferior alveolar nerve injuries, inferior alveo...

  1. Cellular and Molecular Mechanisms of Alveolar Destruction in Emphysema: An Evolutionary Perspective

    OpenAIRE

    Tuder, Rubin M.; Yoshida, Toshinori; Arap, Wadih; Pasqualini, Renata; Petrache, Irina

    2006-01-01

    Emphysema consists of a unique pattern of alveolar destruction, resulting in marked airspace enlargement with reduction of alveolar capillary exchange area. Classical concepts of the pathogenesis of emphysema have relied on the paradigm set by the inflammation and protease/antiprotease imbalance. We propose herein that cigarette smoke constitutes an environmental hazard that causes alveolar destruction by the interaction of apoptosis, oxidative stress, and protease/antiprotease imbalance. We ...

  2. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells

    OpenAIRE

    Wang, Dachun; Haviland, David L.; Burns, Alan R.; Zsigmond, Eva; Wetsel, Rick A.

    2007-01-01

    Alveolar epithelial type II (ATII) cells are small, cuboidal cells that constitute ≈60% of the pulmonary alveolar epithelium. These cells are crucial for repair of the injured alveolus by differentiating into alveolar epithelial type I cells. ATII cells derived from human ES (hES) cells are a promising source of cells that could be used therapeutically to treat distal lung diseases. We have developed a reliable transfection and culture procedure, which facilitates, via genetic selection, the ...

  3. Dexmedetomidine Attenuates Bilirubin-Induced Lung Alveolar Epithelial Cell Death In Vitro and In Vivo*

    OpenAIRE

    Cui, Jian; Zhao, Hailin; Yi, Bin; Zeng, Jing; Lu, Kaizhi; Ma, Daqing

    2015-01-01

    Objective: To investigate bilirubin-induced lung alveolar epithelial cell injury together with the protection afforded by dexmedetomidine. Design: Prospective, randomized, controlled study. Setting: Research laboratory. Subjects: Sprague Dawley rats. Interventions: Alveolar epithelial A549 cell lines were cultured and received bilirubin (from 0 to 160 μM) to explore the protective pathway of dexmedetomidine on bilirubin-induced alveolar epithelial cell injury assessed by immunochemistry and f...

  4. Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells

    OpenAIRE

    Mattes, Charlott; Laube, Mandy; Thome, Ulrich H.

    2014-01-01

    Abstract Alveolar fluid clearance is driven by vectorial Na+ transport and promotes postnatal lung adaptation. The effect of insulin on alveolar epithelial Na+ transport was studied in isolated alveolar cells from 18–19‐day gestational age rat fetuses. Equivalent short‐circuit currents (I SC) were measured in Ussing chambers and different kinase inhibitors were used to determine the pathway of insulin stimulation. In Western Blot measurements the activation of mediators stimulated by insulin ...

  5. Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells

    OpenAIRE

    Mattes, Charlott; Thome, Ulrich H.

    2014-01-01

    Alveolar fluid clearance is driven by vectorial Na+ transport and promotes postnatal lung adaptation. The effect of insulin on alveolar epithelial Na+ transport was studied in isolated alveolar cells from 18–19-day gestational age rat fetuses. Equivalent short-circuit currents (ISC) were measured in Ussing chambers and different kinase inhibitors were used to determine the pathway of insulin stimulation. In Western Blot measurements the activation of mediators stimulated by ...

  6. Alveolar recruitment maneuver in refractory hypoxemia and lobar atelectasis after cardiac surgery: A case report

    OpenAIRE

    Herbst-Rodrigues Marcus; Carvalho Vitor; Abrahao Ludhmila; Nozawa Emilia; Feltrim Maria Ignez; Gomes-Galas Filomena Regina

    2012-01-01

    Abstract Objective This case report describes an unusual presentation of right upper lobe atelectasis associated with refractory hypoxemia to conventional alveolar recruitment maneuvers in a patient soon after coronary artery bypass grafting surgery. Method Case-report. Results The alveolar recruitment with PEEP = 40cmH2O improved the patient’s atelectasis and hypoxemia. Conclusion In the present report, the unusual alveolar recruitment maneuver with PEEP 40cmH2O showed to be safe and efficie...

  7. Pulmonary Alveolar Microlithiasis - Clinico-Radiological dissociation - A case report with Radiological review

    OpenAIRE

    Khaladkar, Sanjay Mhalasakant; Kondapavuluri, Sushen Kumar; Kamal, Anubhav; Kalra, Raghav; Kuber, Rajesh

    2016-01-01

    Pulmonary alveolar microlithiasis (PAM) is a rare chronic lung disease characterized by deposition of intra alveolar calcium and phosphate in bilateral lung parenchyma with predominance in lower and mid zones. Etiology and pathogenesis is not fully understood. However, mutation in SLC34A2 gene that encodes a sodium phosphate co-transporter in alveolar type-II cells resulting in formation and accumulation of microliths rich in calcium phosphate due to impaired clearance is considered the cause...

  8. Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages

    OpenAIRE

    Trapnell, Bruce C.; Carey, Brenna C.; Uchida, Kanji; Suzuki, Takuji

    2009-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by accumulation of pulmonary surfactant, respiratory insufficiency, and increased infections. It occurs in various clinical settings that disrupt surfactant catabolism in alveolar macrophages, including a relatively more common autoimmune disease caused by GM-CSF autoantibodies and a rare congenital disease caused by CSF2RA mutations. Recent results demonstrate that GM-CSF is critical for alveolar macrophage terminal differ...

  9. Pulmonary alveolar proteinosis and superinfection with pulmonary tuberculosis in a case

    OpenAIRE

    Tekgül, Serpil; Bilaceroglu, Semra; Ozkaya, Sevket; Coskun, Ayse; Komurcuoglu, Berna; Cirak, Ali Kadri

    2011-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare and diffuse lung process, characterized by the presence of alveolar spaces filled with amorphous eosinophilic material. Impaired macrophage function and impaired host defence due to abnormalities of surfactant proteins may favor the growth of microorganisms. The association of alveolar proteinosis with mycobacterial infections is rarely reported. The PAP and superinfection with pulmonary tuberculosis is defined by radiologic and histopathologic i...

  10. Therapeutic Whole-Lung Lavage for Pulmonary Alveolar Proteinosis: A Procedural Update.

    Science.gov (United States)

    Abdelmalak, Basem B; Khanna, Ashish K; Culver, Daniel A; Popovich, Marc J

    2015-07-01

    Pulmonary alveolar proteinosis is a disease caused by increased accumulation and impaired clearance of surfactant by alveolar macrophages. This narrative review summarizes the role of therapeutic whole-lung lavage in the management of pulmonary alveolar proteinosis. We describe the preprocedural evaluation, indications, and anesthetic considerations, along with step-by step technical aspects of the procedure, postoperative recovery, potential complications, and long-term outcomes. PMID:26165897

  11. Alveolar Dynamics during Respiration: Are the Pores of Kohn a Pathway to Recruitment?

    OpenAIRE

    Namati, Eman; Thiesse, Jacqueline; de Ryk, Jessica; McLennan, Geoffrey

    2007-01-01

    The change in alveolar size and number during the full breathing cycle in mammals remains unanswered, yet these descriptors are fundamental for understanding alveolar-based diseases and for improving ventilator management. Genetic and environmental mouse models are used increasingly to evaluate the evolution of disease in the peripheral lung; however, little is known regarding alveolar structure and function in the fresh, intact lung. Therefore, we have developed an optical confocal process t...

  12. Biophysical determinants of alveolar epithelial plasma membrane wounding associated with mechanical ventilation

    OpenAIRE

    Hussein, Omar; Walters, Bruce; Stroetz, Randolph; Valencia, Paul; McCall, Deborah; Hubmayr, Rolf D.

    2013-01-01

    Mechanical ventilation may cause harm by straining lungs at a time they are particularly prone to injury from deforming stress. The objective of this study was to define the relative contributions of alveolar overdistension and cyclic recruitment and “collapse” of unstable lung units to membrane wounding of alveolar epithelial cells. We measured the interactive effects of tidal volume (VT), transpulmonary pressure (PTP), and of airspace liquid on the number of alveolar epithelial cells with p...

  13. Early release of surfactant following lung irradiation of alveolar type II cells

    International Nuclear Information System (INIS)

    At 1 hour, 24 hours, and 1 week following irradiation, studies utilizing LAF 1/J mouse lung showed increase of disaturated alveolar phosphatidylcholine (PC) by radiolabelling and alveolar lavage, thus indicating PC as a nearly immediate post-irradiation biomarker. A corresponding decrease of PC in lung tissue following alveolar lavage correlated with an early decrease of lamellar bodies in type II pneumocytes after irrdiation

  14. Perawatan Ortodonti pada Kasus Mutilasi dengan Resorpsi Tulang Alveolar dan Resesi Gingiva (Laporan Kasus

    Directory of Open Access Journals (Sweden)

    Retno Widayati

    2015-09-01

    Full Text Available In the mutilated case in adults, generally malocclusion is often accompanied by less support of periodontal tissues, such as alveolar bone resorption and gingival recession. The treatment of orthodontic is to arrange the teeth into good position and good occlusion, but is widely known to increase the alveolar bone resorption. In handling such case, orthodontist needs to look at factors which do not increase existing alveolar bone resorption and gingival recession. In this case report, it will be reported orthodontic treatment on mutilated case which are accompanied by alveolar bone resorption and gingival recession on a patient of 45 years and 4 months of age.

  15. Self-renewal of pulmonary alveolar macrophages: evidence from radiation chimera studies

    International Nuclear Information System (INIS)

    Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this study CBA mice with or without T6 chromosome marker were used. Under this experimental condition, the majority of alveolar macrophages in mitosis are of host origin even after 45 weeks. These data suggest that alveolar macrophages are a self-renewing population under normal steady-state conditions

  16. ANALISIS PENGARUH ROA, EPS, FINANCIAL LEVERAGE, PROCEED TERHADAP INITIAL RETURN

    Directory of Open Access Journals (Sweden)

    Andhi Wijayanto

    2010-03-01

    Full Text Available Riset ini bertujuan untuk mengetahui pengaruh ROA, EPS, Financial Leverage dan Proceed terhadap initial return. Initial return diperoleh dengan mengukur perbedaan harga pada hari pertama perdangangan di pasar sekunder dengan harga saat IPO. Penelitian ini menduga bahwa ROA, EPS, Proceed mempunyai pengaruh negatif dengan initial return, disisi lain, Financial Leverage diduga mempunyai pengaruh yang positif terhadap initial return. Data pada penelitian ini terdapat dalam prospectus perusahaan. Sampel diambil dengan menggunakan metode purposive sampling dengan dua kriteria yaitu terdiri dari perusahaan yang IPO selama periode tahun 2000-2006 dan underpriced. Dengan kriteria tersebut, 67 perusahaan dijadikan sebagai sampel. Metode analisis menggunakan regresi berganda. Hasil penelitian ini adalah Earning Per-Share (EPS, dan Proceed mempunyai pengaruh negatif dan signifikan terhadap initial return, sedangkan Return on Assets Ratio (ROA, dan Financial Leverage tidak berpengaruh signifikan terhadap initial return. This research aimed to examine the influence of ROA, EPS, Financial Leverage, and Proceed on initial return. Initial return was measured by the difference between the firm’s stock price on the first day in the secondary market and it’s IPO. This research expected that return on assets ratio (ROA, earning per-share (EPS, and proceed negatively associated with initial return. On other hand, financial leverage ratio expected to positively associate with initial return. Data in this study were obtained from company prospectus, ICMD. Sample had been taken by using purposive sampling method with two criterions such as conducted IPO during period 2000-2006 and underpriced. With criterions, 67 companies obtains as sample. The analytical methods used multiple regressions, the empirical result of this research indicate that EPS, and proceed significantly associated with initial returns. Whereas ROA, and financial leverage ratio not

  17. ANALISIS HUBUNGAN JANGKA PANJANG ANTARA ANGGOTA DENGAN KOPERASI JASA KEUANGAN

    Directory of Open Access Journals (Sweden)

    Eko Nur Udin Aziz

    2012-09-01

    Full Text Available Penelitian ini, dilakukan untuk mendeskripsikan dan menganalisis pengaruh Kemampuan Tenaga Pemasaran, Reputasi Lembaga dan Kepuasan Anggota terhadap Hubungan Jangka Panjang yang dimediasi oleh Kepercayaan Anggota, serta pengaruh Kemampuan Tenaga Pemasaran Terhadap Hubungan Jangka Panjang dan pengaruh Kepuasan Anggota terhadap Hubungan Jangka Panjang antara anggota dengan KJKS BMT Bina Ummat Sejahtera. Dari hasil analisis data atas model yang dikembangkan didapatkan nilai indeks pengukuran RMSEA (0.065, GFI (0.928, AGFI (0.822, TLI (0.936 dan CFI (0.968 berada dalam rentang nilai yang baik. Maka model ini dapat diterima karena secara umum model memiliki tingkat goodness of fit yang dapat diterima meskipun nilai chi square dan probabilitas diterima secara marginal. Dari pengujian terhadap enam hipotesis yang diajukan dalam penelitian ini semua hipotesis alternatif didukung yaitu H1, H2, H3, H4, H5 dan H6 dapat didukung.This study aims to describe and to analyze the influence of salesforce ability, Institute reputation and Member Satisfaction toward Long Term Relationships, which are mediated by the trust of the members, as well as the influence of salesforce ability toward Long-Term Relationship and the influence of the members satisfaction toward Long-Term Relationships among members of the BMT KJKS Bina Ummat Sejahtera. Analysis of the data obtained the model developed index measuring the value of RMSEA (0065, GFI (0928, AGFI (0822, TLI (0936 and CFI (0968 is in the range of good value. In addition, this model can be generally accepted as the model which has level of goodness of fit and can be accepted even though the value of chi square and probability is marginally accepted. Examination of the six hypotheses proposed in this study whereas all received as the alternative hypothesis H1, H2, H3, H4, H5 and H6 can be supported.

  18. ANALISIS EFEKTIVITAS PEMBERIAN PINJAMAN PROGRAM PEMBIAYAAN UMKM OLEH KOPERASI

    Directory of Open Access Journals (Sweden)

    Hadi Ismanto

    2014-10-01

    Full Text Available Abstrak: Analisis Efektivitas Pemberian Pinjaman Program Pembiayaan UMKM Oleh Koperasi. Program Pembiayaan memiliki peran yang penting bagi UMKM, namun sering menghadapi masalah penunggakan dan kemacetan pembayaran angsuran. Penelitian ini berupaya untuk mengetahui sebab-sebab tidak lancarnya pengembalian Program Pembiayaan UJKS sehingga diharapkan dapat menyusun strategi yang lebih baik lagi dalam menyeleksi calon peminjam agar angka pinjaman bermasalah dapat ditekan. Populasi dalam penelitian ini adalah semua UMKM yang menjadi Peminjam (peminjam program pembiayaan UJKS Mitra Usaha dan masih tergolong aktif hingga bulan November 2013 dan telah memperoleh fasilitas pembiayaan sekurang-kurangnya enam bulan berjalan. Penelitian ini menemukan bahwa faktor-faktor yang berpengaruh positif terhadap tingkat pengembalian pinjaman (lancar atau menunggak adalah omzet usaha, lama usaha dan nilai plafon pinjaman. Hal ini dapat dijadikan bahan pertimbangan bagi UJKS dalam menjalankan program pembiayaan sehingga menjadi lebih efektif dalam menjalankannya.   Kata Kunci: UMKM, UJKS, Program Pembiayaan, Lancar, dan Macet.   Abstract: Effectiveness Analysis of SMEs Financing Program by Cooperative. Financing programs have an important role to SMEs, but often face the problem of repayment failures and installment payments. This study examines the causes of saving and loan cooperatives’ repayment problems. The population of this study is all SMEs borrowing from Mitra Usaha saving and loan cooperative. Furthermore these SMEs must be categorized as active SMEs until November 2013 and they had been receiving loan for at least six months. The study found that the variables such as: the length of the business, the business volume, and the value of the loan have a positive impact on repayment rate.   Keywords: SMEs, Saving and Loan Cooperative, Financing Program

  19. ANALISIS KEPEMILIKAN JIWA KEWIRAUSAHAAN: EVALUASI OUTCOME PENDIDIKAN MENENGAH DI JAWA

    Directory of Open Access Journals (Sweden)

    Wahyu Purhantara

    2013-10-01

    Full Text Available Abstract: Analisis Kepemilikan Jiwa Kewirausahaan: Evaluasi Outcome Pendidikan Menengah di Jawa. Pendidikan memiliki peran sentral dalam membentuk karakter dan jiwa kewirausahaan. Karena Indonesia memiliki kurang dari 2% dari penduduknya sebagai pengusaha, pendidikan kewirausahaan menjadi hal yang penting. Menurut Drucker, sebuah negara akan makmur jika penduduknya memiliki jiwa kewirausahaan. Pertanyaannya adalah, mengapa semangat kewirausahaan memainkan peran penting dalam pengembangan organisasi, bisnis, dan pengembangan diri? Jawabannya adalah bahwa kewirausahaan melatih orang untuk menjadi mandiri, kreatif, inovatif, kompetitif, berorientasi hasil, menyukai tantangan, bekerja keras, dan sebagainya. Hasil evaluasi terhadap jiwa kewirausahaan berdasarkan hasil proses pendidikan tingkat SMA/SMK di 5 kota di Jawa pada tahun 2011 menunjukkan bahwa mereka tidak memiliki jiwa kewirausahaan seperti yang diharapkan oleh standar kompetensi bagi lulusan SMA / SMK. Keywords: Jiwa Kewirausahaan, Pendidikan Kewirausahaan   Abstract: Entrepreneurial Spirit Analysis: Outcome Evaluation of Secondary Education in Java. Education has central role in forming character and entrepreneurial spirit. Since Indonesia has less than 2% of its inhabitants as entrepreneurs, education of entrepreneurship becomes urgent. According to Drucker, a country would be prosperous if its inhabitants have entrepreneurial spirit. The question is, why entrepreneurial spirit plays an important role in organization development, business, and self development? The answer is that entrepreneurship trains people to become self-supporting, creative, innovative, competitive, result oriented, fond of challenges, hard working, and so on. Result of evaluation on entrepreneurial spirit of high school education outcome in 5 towns in Java in 2011 indicates that they do not have entrepreneurship spirit as expected by the standard of competence for SMA/ SMK graduates. Keywords: entrepreneurial

  20. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENERIMAAN PAJAK

    Directory of Open Access Journals (Sweden)

    Phany Ineke Putri

    2013-09-01

    Full Text Available The purpose of this study was to analyze the influence of population, income per capita, inflation and the number of Trade Permit toward billboard tax revenue in Purbalingga. The results of this study is expected to provide benefit and input to the Local Government of Purbalingga, especially Departement of management of financial income and regional asset. Analysis tool used is multiple linear regression (Multiple Linear Regression Method by the method of least squares Ordinary Least Square (OLS. Jointly test results showed that overall independent variables (population, income per capita, inflation, and the number of trade permit together to show their effects on the billboard tax revenue. Adjusted R-Squared value of 0,951, which means 95,1 percent of the four independent variables. While the remaining 4,9 percent is explained by other causes outside the model. The results showed that the per capita income variable and the number of trade permit have a significant positive effect, the inflation variable has a significant negative effect, whereas a number of population variable have a positive effect which is not significant at α = 5 percent of tax revenue in Purbalingga billboard. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh jumlah penduduk, pendapatan per kapita, inflasi dan jumlah surat ijin usaha perdagangan (SIUP terhadap penerimaan pajak reklame di Kabupaten Purbalingga. Manfaat penelitian ini diharapkan menjadi bahan masukan Pemerintah Kabupaten Purbalingga khususnya Dinas Pengelolaan, Pendapatan, Keuangan dan Aset Daerah. Teknik analisis yang digunakan adalah regresi berganda dengan metode Ordinary Least Square (OLS. Hasil penelitian menunjukkan ada pengaruh secara bersama-sama variabel jumlah penduduk, pendapatan per kapita, inflasi dan jumlah surat ijin usaha perdagangan terhadap penerimaan pajak reklame. Koefisien determinasi 95,1% dapat dijelaskan oleh variabel independen terhadap variabel dependen, dan sisanya

  1. Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Chuan Junlan [West China School of Pharmacy, Sichuan University, Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education (China); Li Yanzhen [Tianjin Institute of Pharmaceutical Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics (China); Yang Likai; Sun Xun [West China School of Pharmacy, Sichuan University, Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education (China); Zhang Qiang [Peking University, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences (China); Gong Tao, E-mail: gongtaoy@126.com; Zhang Zhirong, E-mail: zrzzl@vip.sina.com [West China School of Pharmacy, Sichuan University, Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education (China)

    2013-05-15

    The present study aimed at developing a drug delivery system targeting the densest site of tuberculosis infection, the alveolar macrophages (AMs). Rifampicin (RFP)-loaded solid lipid nanoparticles (RFP-SLNs) with an average size of 829.6 {+-} 16.1 nm were prepared by a modified lipid film hydration method. The cytotoxicity of RFP-SLNs to AMs and alveolar epithelial type II cells (AECs) was examined using MTT assays. The viability of AMs and AECs was above 80 % after treatment with RFP-SLNs, which showed low toxicity to both AMs and AECs. Confocal Laser Scanning Microscopy was employed to observe the interaction between RFP-SLNs and both AMs and AECs. After incubating the cells with RFP-SLNs for 2 h, the fluorescent intensity in AMs was more and remained longer (from 0.5 to 12 h) when compared with that in AECs (from 0.5 to 8 h). In vitro uptake characteristics of RFP-SLNs in AMs and AECs were also investigated by detection of intracellular RFP by High performance liquid chromatography. Results showed that RFP-SLNs delivered markedly higher RFP into AMs (691.7 ng/mg in cultured AMs, 662.6 ng/mg in primary AMs) than that into AECs (319.2 ng/mg in cultured AECs, 287.2 ng/mg in primary AECs). Subsequently, in vivo delivery efficiency and the selectivity of RFP-SLNs were further verified in Sprague-Dawley rats. Under pulmonary administration of RFP-SLNs, the amount of RFP in AMs was significantly higher than that in AECs at each time point. Our results demonstrated that solid lipid nanoparticles are a promising strategy for the delivery of rifampicin to alveolar macrophages selectively.

  2. Alveolar hemorrhage and kidney disease: characteristics and therapy.

    Science.gov (United States)

    Fatma, Lilia Ben; El Ati, Zohra; Lamia, Rais; Aich, Dorra Ben; Madiha, Krid; Wided, Smaoui; Maiz, Hedi Ben; Beji, Somaya; Karim, Zouaghi; Moussa, Fatma Ben

    2013-07-01

    Anti-neutrophil cytoplasmic antibody-associated vasculitis and Goodpasture's glomerular basement membrane disease are the most common causes of diffuse alveolar hemorrhage, a life-threatening disease. Systemic lupus erythematosus and the antiphospholipid syndrome are also causes of alveolar hemorrhage. We retrospectively reviewed 15 cases of diffuse alveolar hemorrhage (DAH) associated with renal diseases. Diagnosis of DAH was based on the presence of bloody bronchoalveolar lavage fluid. There were three men and 12 women, with a mean age of 50.5 years (extremes: 24-74 years). Proteinuria and hematuria were observed, respectively, in 15 and 14 cases. Six patients revealed arterial hypertension. Crescentic glomerulonephritis was diagnosed with kidney biopsies in ten cases. The etiology of renal disease was microscopic polyangiitis (MPA) in seven cases, Wegener disease in four cases, systemic lupus erythematous in one case, cryoglobulinemia in one case, myeloma in one case and propyl-thiouracil-induced MPA in one case. Hemoptysis occurred in 14 cases. The mean serum level of hemoglobin was 7.1 g/dL (5.1-10 g/dL). The mean serum creatinine concentration was 7.07 mg/dL (2.4-13.7 mg/dL). Gas exchange was severely compromised, with an oxygenation index <80 mmHg in 14 patients and <60 mmHg in seven patients. Bronchoalveolar lavage was performed in 11 cases, and had positive findings for hemorrhage in all. Methylprednisolone pulses and cyclophosphamide were used in 14 patients. Plasmapheresis was performed in three cases. One patient received cycles of Dexamethasome-Melphalan. Three patients died as a result of DAH. The mortality rate in our study was 20%. PMID:23816724

  3. Alveolar hemorrhage and kidney disease: Characteristics and therapy

    Directory of Open Access Journals (Sweden)

    Lilia Ben Fatma

    2013-01-01

    Full Text Available Anti-neutrophil cytoplasmic antibody-associated vasculitis and Goodpasture′s glomerular basement membrane disease are the most common causes of diffuse alveolar hemorrhage, a life-threatening disease. Systemic lupus erythematosus and the antiphospholipid syndrome are also causes of alveolar hemorrhage. We retrospectively reviewed 15 cases of diffuse alveolar hemorrhage (DAH associated with renal diseases. Diagnosis of DAH was based on the presence of bloody bronchoalveolar lavage fluid. There were three men and 12 women, with a mean age of 50.5 years (extremes: 24-74 years. Proteinuria and hematuria were observed, respectively, in 15 and 14 cases. Six patients revealed arterial hypertension. Crescentic glomerulonephritis was diagnosed with kidney biopsies in ten cases. The etiology of renal disease was microscopic polyangiitis (MPA in seven cases, Wegener disease in four cases, systemic lupus erythematous in one case, cryoglobulinemia in one case, myeloma in one case and propyl-thiouracil-induced MPA in one case. Hemoptysis occurred in 14 cases. The mean serum level of hemoglobin was 7.1 g/dL (5.1-10 g/dL. The mean serum creatinine concentration was 7.07 mg/dL (2.4-13.7 mg/dL. Gas exchange was severely compromised, with an oxygenation index <80 mmHg in 14 patients and <60 mmHg in seven patients. Bronchoalveolar lavage was performed in 11 cases, and had positive findings for hemorrhage in all. Methylprednisolone pulses and cyclophosphamide were used in 14 patients. Plasmapheresis was performed in three cases. One patient received cycles of Dexamethasome-Melphalan. Three patients died as a result of DAH. The mortality rate in our study was 20%.

  4. Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans

    Science.gov (United States)

    Taylor, Natalie E.; Baker, Sarah E.; Olson, Thomas P.; Lalande, Sophie; Johnson, Bruce D.; Snyder, Eric M.

    2016-01-01

    BACKGROUND Beta-2 adrenergic receptors (β2ARs) are located throughout the body including airway and alveolar cells. The β2ARs regulate lung fluid clearance through a variety of mechanisms including ion transport on alveolar cells and relaxation of the pulmonary lymphatics. We examined the effect of an inhaled β2-agonist (albuterol) on alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC) in healthy humans. METHODS We assessed the diffusing capacity of the lungs for carbon monoxide (DLCO) and nitric oxide (DLNO) at baseline, 30 minutes, and 60 minutes following nebulized albuterol (2.5 mg, diluted in 3 mL normal saline) in 45 healthy subjects. Seventeen subjects repeated these measures following nebulized normal saline (age = 27 ± 9 years, height = 165 ± 21 cm, weight = 68 ± 12 kg, BMI = 26 ± 9 kg/m2). Cardiac output (Q), heart rate, systemic vascular resistance (SVR), blood pressure, oxygen saturation, forced expiratory volume at one-second (FEV1), and forced expiratory flow at 50% of forced vital capacity (FEF50) were assessed at baseline, 30 minutes, and 60 minutes following the administration of albuterol or saline. RESULTS Albuterol resulted in a decrease in SVR, and an increase in Q, FEV1, and FEF50 compared to saline controls. Albuterol also resulted in a decrease in VC at 60 minutes post albuterol. Both albuterol and normal saline resulted in no change in DLCO or DM when assessed alone, but a significant increase was observed in DM when accounting for changes in VC. CONCLUSION These data suggest that nebulized albuterol improves pulmonary function in healthy humans, while nebulization of both albuterol and saline results in an increase in DM/VC.

  5. Plasma cell gingivitis with severe alveolar bone loss.

    Science.gov (United States)

    Kumar, Vivek; Tripathi, Amitandra Kumar; Saimbi, Charanjit Singh; Sinha, Jolly

    2015-01-16

    Plasma cell gingivitis is a rare benign condition of the gingiva characterised by sharply demarcated erythaematous and oedematous gingiva often extending up to the muco gingival junction. It is considered a hypersensitive reaction. It presents clinically as a diffuse, erythaematous and papillary lesion of the gingiva, which frequently bleeds, with minimal trauma. This paper presents a case of a 42-year-old man who was diagnosed with plasma cell gingivitis, based on the presence of plasma cells in histological sections, and severe alveolar bone loss at the affected site, which was managed by surgical intervention.

  6. Does Orthodontic Treatment Affect the Alveolar Bone Density?

    Science.gov (United States)

    Yu, Jian-Hong; Huang, Heng-Li; Liu, Chien-Feng; Wu, Jay; Li, Yu-Fen; Tsai, Ming-Tzu; Hsu, Jui-Ting

    2016-03-01

    Few studies involving human participants have been conducted to investigate the effect of orthodontic treatment on alveolar bone density around the teeth. Our previous study revealed that patients who received 6 months of active orthodontic treatment exhibited an ∼24% decrease in alveolar bone density around the teeth. However, after an extensive retention period following orthodontic treatment, whether the bone density around the teeth can recover to its original state from before the treatment remains unclear, thus warranting further investigation.The purpose of this study was to assess the bone density changes around the teeth before, during, and after orthodontic treatment.Dental cone-beam computed tomography (CBCT) was used to measure the changes in bone density around 6 teeth in the anterior maxilla (maxilla central incisors, lateral incisors, and canines) of 8 patients before and after orthodontic treatment. Each patient underwent 3 dental CBCT scans: before treatment (T0); at the end of 7 months of active orthodontic treatment (T1); after several months (20-22 months) of retention (T2). The Friedman test was applied to evaluate the changes in the alveolar bone density around the teeth according to the 3 dental CBCT scans.From T0 to T1, a significant reduction in bone density was observed around the teeth (23.36 ± 10.33%); by contrast, a significant increase was observed from T1 to T2 (31.81 ± 23.80%). From the perspective of the overall orthodontic treatment, comparing the T0 and T2 scans revealed that the bone density around the teeth was relatively constant (a reduction of only 0.75 ± 19.85%). The results of the statistical test also confirmed that the difference in bone density between T0 and T2 was nonsignificant.During orthodontic tooth movement, the alveolar bone density around the teeth was reduced. However, after a period of bone recovery, the reduced bone density recovered to its previous state from before the orthodontic treatment

  7. Case report 501: Alveolar soft parts sarcoma with pulmonary metastases

    International Nuclear Information System (INIS)

    Alveolar soft part sarcoma (ASPS) is a rare, soft tissue malignancy, usually presenting in young adults. We report a patient with ASPS in the thigh, evaluated with plain films, computed tomography, and a radionuclide scan. The findings in this patient and those in which CT findings have been reported in the literature, show a similar appearance which we believe is highly suggestive of this unusual tumor. The combination of a soft tissue lesion, that on CT appears highly vascular, with features suggestive of an arteriovenous malformation, in association with multiple pulmonary nodules and a bone scan with features suggestive of infection should lead to a consideration of this rare entity. (orig./GDG)

  8. Bruxism elicited by inferior alveolar nerve injury: a case report.

    Science.gov (United States)

    Melis, Marcello; Coiana, Carlo; Secci, Simona

    2012-02-01

    The aim of this case report is to describe the history of a patient who received an injury to the right inferior alveolar nerve after placement of a dental implant, with bruxism noted afterward. The symptoms were managed by the use of an occlusal appliance worn at night and occasionally during the day, associated with increased awareness of parafunction during the day to reduce muscle pain and fatigue. Paresthesia of the teeth, gingiva, and lower lip persisted but were reduced during appliance use. PMID:22254232

  9. A 3-step therapeutic strategy for severe alveolar proteinosis.

    Science.gov (United States)

    Noirez, Leslie; Koutsokera, Angela; Pantet, Olivier; Duss, François-Régis; Eggimann, Philippe; Tozzi, Piergiorgio; Gonzalez, Michel; Coronado, Marcos; Nicod, Laurent P; Lovis, Alban

    2015-04-01

    Pulmonary alveolar proteinosis (PAP) is characterized by accumulation of lipoproteinaceous material in the terminal airways. Whole lung lavage (WLL) remains the gold standard treatment but may be particularly challenging in cases of severe hypoxemia. We present a 3-step strategy that was used in a patient with PAP-associated refractory hypoxemia and that combined venovenous extracorporeal membrane oxygenation (vvECMO), double-lumen orotracheal intubation, and bilateral multisegmental sequential lavage (MSL). The procedure was well tolerated and permitted weaning from the ventilator. PMID:25841841

  10. Pulmonary alveolar proteinosis in children: A case series

    Directory of Open Access Journals (Sweden)

    Seyyed Ahmad Tabatabaei

    2010-01-01

    Full Text Available Pulmonary alveolar proteinosis, (PAP is a rare disease of unknown etiology, characterized by accumulation of intraalveolar proteinaceous material which is rich in lipid and positive on periodic acid-Schiff stain. Two clinically different pediatric types have been defined as congenital PAP which is fulminant and fatal, and a late-onset PAP which is similar to the adult form and less severe. Eight children with late-onset PAP were hospitalized from 1998 to 2005 in Mofid Children Hospital. Characteristics of these patients and the methods of diagnosis and treatment are presented in this case series.

  11. Pulmonary alveolar proteinosis: another autoimmune disease associated with sarcoidosis?

    Science.gov (United States)

    Boerner, Eda Burcu; Costabel, Ulrich; Wessendorf, Thomas Ernst; Theegarten, Dirk; Hetzel, Martin; Drent, Marjolein; Bonella, Francesco

    2016-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of surfactant phospholipids and lipoproteins within the alveoli.  Here we report on a female patient who was diagnosed with autoimmune PAP and successfully treated with whole lung lavage (WLL). 15 months after PAP diagnosis the patient developed marked fatigue. Additional tests revealed the diagnosis of sarcoidosis. We can only speculate that PAP and sarcoidosis in our patient are linked to each other based on the fact that other autoimmune disorders have also been associated with sarcoidosis. PMID:27055841

  12. ANALISIS FAKTOR PEMANFAATAN POLINDES MENURUT KONSEP MODEL PERILAKU KESEHATAN ”ANDERSON” (Analisis Lanjut Data RISKESDAS 2007

    Directory of Open Access Journals (Sweden)

    Astridya Paramita

    2013-11-01

    dari kajian analisis lanjut data sekunder Riset Kesehatan Dasar (Riskesdas 2007. Tehnik analisis yang digunakan adalah uji chi square dan regresi logistik multiple untuk memperoleh gambaran hubungan antara karakteristik, status sosial rumah tangga, dan kemudahan akses Polindes terhadap pemanfaatan Polindes. Hasil kajian menunjukkan pemanfaaatan Polindes oleh rumah tangga di Indonesia masih rendah dengan alasan tidak butuh pelayanan Polindes. Uji Chi Square menunjukkan terdapat hubungan bermakna antara jarak tempuh, waktu tempuh, klasifikasi desa, pengeluaran per kapita, pekerjaan, pendidikan, dan umur kepala rumah tangga terhadap pemanfaatan Polindes. Hasil uji regresi logistik multiple menunjukkan adanya kecenderungan pemanfaatan Polindes oleh rumah tangga berdasarkan jarak tempuh, waktu tempuh, klasifikasi desa, pengeluaran per kapita, pekerjaan, pendidikan dan umur kepala rumah tangga. Kesimpulan yang dapat diambil dari tulisan ini adalah Polindes lebih tepat didesain untuk kelompok rumah tangga pra sejahtera, berpendidikan rendah, bermata pencaharian petani atau nelayan, dan berlokasi di pedesaan atau daerah terpencil dengan keterbatasan alat transportasi. Kata kunci: karakteristik dan status sosial rumah tangga, aksesibilitas Polindes, pemanfaatan Polindes

  13. Postoperative morbidity after reconstruction of alveolar bone defects with chin bone transplants in cleft patients - 111 consecutive patients

    DEFF Research Database (Denmark)

    Andersen, Kristian; Nørholt, Sven Erik; Knudsen, Johan;

    Postoperative morbidity after reconstruction of alveolar bone defects with chin bone transplants in cleft patients - 111 consecutive patients......Postoperative morbidity after reconstruction of alveolar bone defects with chin bone transplants in cleft patients - 111 consecutive patients...

  14. An Unusual Radiologic Manifestation of Pulmonary Tuberculosis with Bilateral Multiple Lung Nodules and Diffuse Alveolar Hemorrhage: A Case Report

    International Nuclear Information System (INIS)

    Pulmonary tuberculosis presenting as bilateral multiple lung nodules or diffuse alveolar hemorrhage is very rare. Here, we report a case of pulmonary tuberculosis presenting as bilateral multiple lung nodules and diffuse alveolar hemorrhage mimicking granulomatous vasculitis, such as Wegener's granulomatosis.

  15. Is there a relation between local bone quality as assessed on panoramic radiographs and alveolar bone level?

    Science.gov (United States)

    Nackaerts, Olivia; Gijbels, Frieda; Sanna, Anna-Maria; Jacobs, Reinhilde

    2008-03-01

    The aim was to explore the relation between radiographic bone quality on panoramic radiographs and relative alveolar bone level. Digital panoramic radiographs of 94 female patients were analysed (mean age, 44.5; range, 35-74). Radiographic density of the alveolar bone in the premolar region was determined using Agfa Musica software. Alveolar bone level and bone quality index (BQI) were also assessed. Relationships between bone density and BQI on one hand and the relative loss of alveolar bone level on the other were assessed. Mandibular bone density and loss of alveolar bone level were weakly but significantly negatively correlated for the lower premolar area (r = -.27). The BQI did not show a statistically significant relation to alveolar bone level. Radiographic mandibular bone density on panoramic radiographs shows a weak but significant relation to alveolar bone level, with more periodontal breakdown for less dense alveolar bone. PMID:17690924

  16. Is there a relation between local bone quality as assessed on panoramic radiographs and alveolar bone level?

    Science.gov (United States)

    Nackaerts, Olivia; Gijbels, Frieda; Sanna, Anna-Maria; Jacobs, Reinhilde

    2008-03-01

    The aim was to explore the relation between radiographic bone quality on panoramic radiographs and relative alveolar bone level. Digital panoramic radiographs of 94 female patients were analysed (mean age, 44.5; range, 35-74). Radiographic density of the alveolar bone in the premolar region was determined using Agfa Musica software. Alveolar bone level and bone quality index (BQI) were also assessed. Relationships between bone density and BQI on one hand and the relative loss of alveolar bone level on the other were assessed. Mandibular bone density and loss of alveolar bone level were weakly but significantly negatively correlated for the lower premolar area (r = -.27). The BQI did not show a statistically significant relation to alveolar bone level. Radiographic mandibular bone density on panoramic radiographs shows a weak but significant relation to alveolar bone level, with more periodontal breakdown for less dense alveolar bone.

  17. Analisis Hubungan Receivable Turnover Ratio, Inventory Turnover Ratio, dan Total Asset Turnover Ratio Dengan Kemampulabaan Perusahaan Pada PTPN III (Persero) Medan

    OpenAIRE

    Panjaitan, Fitry Bertha H.

    2010-01-01

    Tujuan penelitian adalah untuk menganalisis hubungan Receivable Turnover Ratio, Inventory Turnover Ratio, dan Total Asset Turnover Ratio dengan kemampulabaan perusahaan pada PTPN III (Persero) Medan. Penulis menarik hipotesis bahwa Receivable Turnover Ratio, Inventory Turnover Ratio, dan Total Asset Turnover Ratio berhubungan positif dengan kemampulabaan perusahaan pada PTPN III (Persero) Medan. Metode penelitian yang digunakan adalah metode analisis deskriptif dan metode analisis K...

  18. Alterations in the alveolar epithelium after injury leading to pulmonary fibrosis

    OpenAIRE

    Kasper, M; Haroske, G.

    1996-01-01

    This review discusses current knowledge of the involvement of the alveolar epithelium in tissue remodelling during fibrogenesis. The purpose of the present paper is to give an overview, including the authors' own results, of knowledge of ultrastructural alterations, proliferation kinetics and phenotypic changes of pneumocytes in experimental and clinical pathology of pulmonary fibrosis. After lung injury, the alveolar epithelial cells show ultrastructural alter...

  19. Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate

    NARCIS (Netherlands)

    J. Guo; C. Li; Q. Zhang; G. Wu; S.A. Deacon; J. Chen; H. Hu; S. Zou; Q. Ye

    2011-01-01

    BACKGROUND: Secondary alveolar bone grafting has been widely used to reconstruct alveolar cleft. However, there is still some controversy. OBJECTIVES: To compare the effectiveness and safety of different secondary bone grafting methods. SEARCH STRATEGY: The final electronic and handsearches were car

  20. Morbidity of chin bone transplants used for reconstructing alveolar defects in cleft patients

    NARCIS (Netherlands)

    Booij, A; Raghoebar, GM; Jansma, J; Kalk, WWI; Vissink, A

    2005-01-01

    Objective: The aim of this study was to evaluate the objective and subjective morbidity of symphyseal chin bone harvesting used for reconstruction of alveolar defects in young cleft patients. Design: All patients who had undergone chin bone harvesting for alveolar cleft reconstruction in the period

  1. An "S-shaped" relationship between smoking duration and alveolar bone loss : generating a hypothesis

    NARCIS (Netherlands)

    Schuller, A A; Holst, D

    2001-01-01

    BACKGROUND: A number of epidemiological studies have shown that smoking is a risk factor for periodontal disease. Little is known about the relationship between smoking duration and alveolar bone loss. The purpose of this research was to describe the prevalence of alveolar bone loss according to smo

  2. Genesis of amorphous calcium carbonate containing alveolar plates in the ciliate Coleps hirtus (Ciliophora, Prostomatea).

    Science.gov (United States)

    Lemloh, Marie-Louise; Marin, Frédéric; Herbst, Frédéric; Plasseraud, Laurent; Schweikert, Michael; Baier, Johannes; Bill, Joachim; Brümmer, Franz

    2013-02-01

    In the protist world, the ciliate Coleps hirtus (phylum Ciliophora, class Prostomatea) synthesizes a peculiar biomineralized test made of alveolar plates, structures located within alveolar vesicles at the cell cortex. Alveolar plates are arranged by overlapping like an armor and they are thought to protect and/or stiffen the cell. Although their morphology is species-specific and of complex architecture, so far almost nothing is known about their genesis, their structure and their elemental and mineral composition. We investigated the genesis of new alveolar plates after cell division and examined cells and isolated alveolar plates by electron microscopy, energy-dispersive X-ray spectroscopy, FTIR and X-ray diffraction. Our investigations revealed an organic mesh-like structure that guides the formation of new alveolar plates like a template and the role of vesicles transporting inorganic material. We further demonstrated that the inorganic part of the alveolar plates is composed out of amorphous calcium carbonate. For stabilization of the amorphous phase, the alveolar vesicles, the organic fraction and the element phosphorus may play a role.

  3. Pulmonary alveolar microlithiasis with the absence of technetium-99m MDP uptake of lungs

    International Nuclear Information System (INIS)

    The authors report a patient with alveolar microlithiasis who was treated for miliary tuberculosis eight years earlier and whose Tc-99m MDP scan revealed absent lung uptake. Diagnosis was established by bronchoalveolar lavage. Both the roentgenogram and computed tomography of the chest confirmed alveolar microlithiasis

  4. Changes in alveolar bone support induced by the Herbst appliance: a tomographic evaluation

    Directory of Open Access Journals (Sweden)

    João Paulo Schwartz

    2016-04-01

    Full Text Available ABSTRACT Objective: This study evaluated alveolar bone loss around mandibular incisors, induced by the Herbst appliance. Methods: The sample consisted of 23 patients (11 men, 12 women; mean age of 15.76 ± 1.75 years, Class II, Division 1 malocclusion, treated with the Herbst appliance. CBCT scans were obtained before treatment (T0 and after Herbst treatment (T1. Vertical alveolar bone level and alveolar bone thickness of mandibular incisors were assessed. Buccal (B, lingual (L and total (T bone thicknesses were assessed at crestal (1, midroot (2 and apical (3 levels of mandibular incisors. Student's t-test and Wilcoxon t-test were used to compare dependent samples in parametric and nonparametric cases, respectively. Pearson's and Spearman's rank correlation analyses were performed to determine the relationship of changes in alveolar bone thickness. Results were considered at a significance level of 5%. Results: Mandibular incisors showed no statistical significance for vertical alveolar bone level. Alveolar bone thickness of mandibular incisors significantly reduced after treatment at B1, B2, B3, T1 and significantly increased at L2. The magnitude of the statistically significant changes was less than 0.2 mm. The changes in alveolar bone thickness showed no statistical significance with incisor inclination degree. Conclusions: CBCT scans showed an association between the Herbst appliance and alveolar bone loss on the buccal surface of mandibular incisors; however, without clinical significance.

  5. The use of digital periapical radiographs to study the prevalence of alveolar domes

    Science.gov (United States)

    Xambre, Pedro Augusto Oliveira Santos; Valerio, Claudia Scigliano; e Alves Cardoso, Claudia Assunção; Custódio, Antônio Luís Neto

    2016-01-01

    Purpose In the present study, we coined the term 'alveolar dome' and aimed to demonstrate the prevalence of alveolar domes through digital periapical radiographs. Materials and Methods This study examined 800 digital periapical radiographs in regard to the presence of alveolar domes. The periapical radiographs were acquired by a digital system using a photostimulable phosphor (PSP) plate. The χ2 test, with a significance level of 5%, was used to compare the prevalence of alveolar domes in the maxillary posterior teeth and, considering the same teeth, to verify the difference in the prevalence of dome-shaped phenomena between the roots. Results The prevalence of alveolar domes present in the first pre-molars was statistically lower as compared to the other maxillary posterior teeth (pfirst and second molars. Considering the maxillary first and second molars, it was observed that the palatal root presented a lower prevalence of alveolar domes when compared to the distobuccal and mesiobuccal roots (pfirst and second molars presented a greater prevalence of alveolar domes, especially in the buccal roots, followed by the third molars and second pre-molars. Although the periapical radiograph is a two-dimensional method, it can provide dentists with the auxiliary information necessary to identify alveolar domes, thus improving diagnosis, planning, and treatment.

  6. Role of alveolar macrophage lysosomes in metal detoxification.

    Science.gov (United States)

    Berry, J P; Zhang, L; Galle, P; Ansoborlo, E; Hengé-Napoli, M H; Donnadieu-Claraz, M

    1997-02-15

    The intracellular behaviour of different toxic mineral elements inhaled as soluble aerosols or as insoluble particles was studied in the rat by electron microscopy, electron probe microanalysis, and electron microdiffraction. This study showed that, after inhalation, aerosols of soluble elements like cerous chloride, chromic chloride, uranyl nitrate, and aluminium chloride, are concentrated in the lysosomes of alveolar macrophages and are precipitated in the lysosomes in the form of insoluble phosphate, probably due to the activity of acid phosphatase (intralysosomial enzyme). Also, after inhalation of crystalline particles that are insoluble or poorly soluble in water such as the illites (phyllosilicates), ceric oxides (opaline), and industrial uranium oxides (U3O8), the small crystals are captured by the alveolar macrophage lysosomes and transformed over time into an amorphous form. This structural transformation is associated with changes in the chemical nature of particles inhaled in the oxide form. Microanalysis of amorphous deposits observed after inhalation of uranium or ceric oxides has shown that they contain high concentrations of phosphorus associated with the initial elements cerium and uranium. These different processes tend to limit the diffusion of these toxic elements within the organism, whether they are inhaled in soluble form or not. PMID:9140931

  7. Primary pulmonary alveolar proteinosis: computed tomography features at diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Berteloot, Laureline; Emond-Gonsard, Sophie; Mamou-Mani, Tania; Lambot, Karen; Grevent, David [Hopital Necker Enfants-Malades, Department of Pediatric Radiology, Paris (France); Taam, Rola Abou; Le Bourgeois, Muriel [Hopital Necker Enfants-Malades, Department of Pediatric Pneumology and Allergology, Paris (France); Elie, Caroline [Hopital Necker Enfants-Malades, Department of Biostatistics, Paris (France); Paris Descartes University, Paris (France); Delacourt, Christophe; Blic, Jacques de [Hopital Necker Enfants-Malades, Department of Pediatric Pneumology and Allergology, Paris (France); Paris Descartes University, Paris (France); Brunelle, Francis [Hopital Necker Enfants-Malades, Department of Pediatric Radiology, Paris (France); Paris Descartes University, Paris (France)

    2014-07-15

    Pulmonary alveolar proteinosis (PAP) is characterized by an abnormal accumulation of periodic acid-schiff-positive lipoproteinaceous material in the alveoli. Early diagnosis allows setting up of therapeutic lung lavages, which reduces the need for oxygen supplementation and weight gain. To provide a description of radiological features by CT at the onset of primary PAP in children. The clinical and radiological data of 24 patients, including 16 boys and 8 girls (median age: 12 months), diagnosed with a primary form of PAP between April 1992 and May 2012 in a tertiary referral hospital, were retrospectively reviewed. CT images were examined for the presence of alveolar and interstitial elementary lesions. Correlation between clinical and radiological findings was assessed. The types of elementary lesions detected were: ground-glass opacities (n = 24), intralobular lines (n = 24), thickened interlobular septa (n = 22), thickened fissures (n = 21), airspace consolidation (n = 16), hyperinflation (n = 16), cystic lesions (n = 2) and micronodules (n = 1). A crazy-paving pattern was found in 92% of cases. Consolidation and hyperinflation were especially detected in younger children (median age, 8 months, P < 0.01). A density dependent gradient was found. The distribution of the lesions was symmetrical. There was no correlation between radiological and clinical data of severity of the disease. CT findings are suggestive of diagnosis of PAP in immunocompetent children with chronic respiratory failure. (orig.)

  8. Microtomography of the human tooth-alveolar bone complex

    Science.gov (United States)

    Dalstra, Michel; Cattaneo, Paolo M.; Beckmann, Felix; Sakima, Maurício T.; Lemor, Carsten; Laursen, Morten G.; Melsen, Birte

    2006-08-01

    In this study the structure of the adult human dentoalveolar process is examined using conventional and synchrotron radiation-based microtomography (SRμCT). Mandibular and maxillary segments containing two to five adjacent teeth were harvested at autopsy from 49 adult donors. These segments were embedded in blocks of methylmetacrylate and scanned using a conventional table-top μCT-scanner at a pixel size and slice thickness of 35 μm. A few segments were also scanned at a synchrotron facility at an initial pixel size of 16.4 μm, which was binned by a factor 2 to result in an effective voxel size of almost 32.8 μm. The three-dimensional reconstructions revealed how intricately the teeth are supported by the alveolar bone. Furthermore, this support is highly inhomogeneous with respect to the buccal, mesial, lingual and distal quadrants. Reflecting their various degrees of mineralization, tissues like bone, dentine, enamel and cementum, could well be identified, especially in the scans made with SRμCT. Despite comparable voxel sizes, the reconstructed data-sets obtained with conventional μCT were less detailed and somewhat fuzzy in appearance compared to the data-sets of SRμCT. However, for quantification of macroscopical features like the thickness of the alveolar wall or the presence of dehiscences/fenestrations this seemed sufficient.

  9. Bronchiolo-alveolar cell carcinoma: A review of 11 cases

    International Nuclear Information System (INIS)

    Eleven patients with proved Bronchiolo-alveolar cell carcinoma were found in the chest department of the national menical center from 1975 to 1981. The clinical od Bronchiolo-alveolar cell carcinoma is recently increased as primary lung carcinoma. The results were as follow. 1. The ratio of male and female was 5 : 6, and an incidence of 4.4% among total primary lung cancer patients. The highest incidence (3 of cases) was seen in the sixth decade, and the remaining cases were evenly distributed in the third, fourth, and fifth decades of life. Among them youngest was 29 years old and the oldest was 66 years old. 2. Clinical and radiological initial diagnosis prior to the final diagnosis were as follows; pulmonary tuberculosis; 7 cases, pneumonia; 1 case, bronchiectasis; 1 case, and lung cancer; 2 cases. 3. Radiological examination of chest presented several pictures; most commonly, homogenous or patchy infiltration; 6 cases, nodular or mass like densities; 2 cases, disseminated nodular or military patterns; 2 cases, and reticular pattern; 1 case. 4. Bronchogram revealed no contributable findings except one case of complete tappering obstruction of the segmental bronchus. Therefore we arrive at the conclusion that early diagnosis will result in increased resectability and improved survival so aggressive diagnostic work-up for suspicious pulmonary infiltrate is necessary

  10. Primary pulmonary alveolar proteinosis: computed tomography features at diagnosis

    International Nuclear Information System (INIS)

    Pulmonary alveolar proteinosis (PAP) is characterized by an abnormal accumulation of periodic acid-schiff-positive lipoproteinaceous material in the alveoli. Early diagnosis allows setting up of therapeutic lung lavages, which reduces the need for oxygen supplementation and weight gain. To provide a description of radiological features by CT at the onset of primary PAP in children. The clinical and radiological data of 24 patients, including 16 boys and 8 girls (median age: 12 months), diagnosed with a primary form of PAP between April 1992 and May 2012 in a tertiary referral hospital, were retrospectively reviewed. CT images were examined for the presence of alveolar and interstitial elementary lesions. Correlation between clinical and radiological findings was assessed. The types of elementary lesions detected were: ground-glass opacities (n = 24), intralobular lines (n = 24), thickened interlobular septa (n = 22), thickened fissures (n = 21), airspace consolidation (n = 16), hyperinflation (n = 16), cystic lesions (n = 2) and micronodules (n = 1). A crazy-paving pattern was found in 92% of cases. Consolidation and hyperinflation were especially detected in younger children (median age, 8 months, P < 0.01). A density dependent gradient was found. The distribution of the lesions was symmetrical. There was no correlation between radiological and clinical data of severity of the disease. CT findings are suggestive of diagnosis of PAP in immunocompetent children with chronic respiratory failure. (orig.)

  11. Peptide secreted by human alveolar macrophages releases neutrophil granule contents

    International Nuclear Information System (INIS)

    A monoclonal antibody was developed against an 8000-kDa enzyme-releasing peptide (ERP) released from human alveolar macrophages. ERP was isolated on an immunoaffinity column containing the antibody bound to staphylococcal protein A-Sepharose, and by autoradiography. Release of ERP from the macrophages is not changed by plastic adherence, phagocytosis, calcium ionophore, or phorbol esters. The peptide was not antigenically similar to interferon-γ, tumor necrosis factor, or interleukin lα or 1β. The release of constituents from azurophilic and specific granules was the main identified biologic function of ERP. ERP was a more effective secretagogue in the untreated neutrophils and f-met-leu-phe was more effective in the cytochalasin B-treated neutrophils. Absorption of ERP from macrophage-conditioned medium removed a small amount of the chemotactic activity; however, the immunopurified peptide was not chemotactic or chemokinetic for neutrophils, and at high concentrations, it suppressed base line chemokinesis. Treatment of washed macrophages with trypsin released active ERP of approximately the same m.w. of spontaneously secreted ERP. These studies showed that human alveolar macrophages release a peptide which is a secretagogue for human neutrophils under conditions which may be encountered in the lungs during certain disease states. Proteolytic enzymes which are free in the lungs may release the peptide and lead to the secretion of neutrophil enzymes

  12. The role of the alveolar macrophage in jaagsiekte

    International Nuclear Information System (INIS)

    The increase of alveolar macrophages in jaagsiekte sheep lungs is not caused by excessive surfactant production but is due to a chemotactic factor secreted by the tumour cells. Both growth inhibitory and growth stimulatory factors were detected in vitro in medium from cultures of lung lavage cells exposed to jaagsiekte tumour cell supernatant. The macrophage component of the lavage cells was found to produce a growth stimulatory factor that was replaced by a growth inhibitory factor following exposure to jaagsiekte tumour cell supernatant. Whether these factors stimulated or inhibited DNA synthesis depended to some extent on whether the indicators cells were transformed or not. Alveolar macrophages infected with lentivirus were found to be chemotactically inhibited as well as having a reduced leukocine production potential. Peripheral blood monocytes isolated from sheep suffering with acute jaagsiekte were depressed with regard to their DNA synthesis potential. 3H-thymidine incorporation assay was used to determine if there was any difference in the division potential of blood monocytes isolated from JS-sheep compared to normal sheep

  13. A 55 years old man with pulmonary alveolar microlithiasis

    Directory of Open Access Journals (Sweden)

    Rebeen R Saeed

    2014-01-01

    Full Text Available Pulmonary alveolar microlithiasis (PAM is a very rare diffuse chronic lung disease characterized by deposition of small spherules of calcium phosphate within the alveolar cavity. The disease is usually seen from birth up to 40 years of age and is usually diagnosed incidentally during radiography of the chest for other reasons. Most of patients are asymptomatic or having very mild symptoms and the majority of patients either have normal or restrictive pulmonary function test. Clinically, the course of the disease is different; it remains static in few patients or it may progress to pulmonary fibrosis, respiratory failure and cor pulmonale in others. In this case report, we present a 55-year-old man who presented with moderate shortness of breath which has progressed from mild symptoms with in the previous years. His chest high-resolution CT scan showed diffusely scattered, ill-defined little shadowy micronodules which involve the left lung; lingula and left lower lobe in particular. A lung biopsy confirmed the diagnosis of PAM. He was followed up for 1 year with treatment by steroid and alendronate, and no progression was noticed in fact improvement in pulmonary function test noticed. This is the first case report of PAM in Kurdistan.

  14. Alveolar Bone Housing- A Modified Wilkodontics Approach- A Case Report.

    Science.gov (United States)

    Awasthi, Eshan; Sanjay, Kothamachu; Bhongade, M L; Shrivastav, Sunita

    2016-08-01

    Accelerated orthodontic treatment is the need of the hour in current scenario as the conventional orthodontics is time taking. Corticotomy assisted orthodontics have been used for years to reduce the treatment duration by reducing the resistance provided by alveolar bone housing. This case report describes the orthodontic treatment combined with the modification in conventional wilkodontic technique in a patient to accelerate tooth movement and shorten the treatment time with an anterior open bite and flared and spaced upper and lower incisors. Firstly plaque control was achieved with supra and subgingival scaling. A modified approach using periodontal access flap followed by vertical bone cuts in the cortical bone from the crest of the alveolar bone margin to 2mm-3mm below the apices of all the anterior teeth extending from upper left canine to upper right canine were performed. These vertical cuts were joined by horizontal cuts apically and flap repositioned. An MBT 0.018 inch appliance was bonded. Orthodontic therapy proceeded with frequent activation of the appliances to retract the incisors every two weeks. The total treatment time was four and half months with active period of two months and no adverse effects were observed at the end of active treatment. The modified decortication technique reduced the treatment time to a considerable extent. The interdental spacing closed and optimum overjet and overbite was achieved. PMID:27656577

  15. Alveolar hemorrhage in systemic lupus erythematosus: a cohort review.

    Science.gov (United States)

    Andrade, C; Mendonça, T; Farinha, F; Correia, J; Marinho, A; Almeida, I; Vasconcelos, C

    2016-01-01

    Diffuse alveolar hemorrhage (DAH) is a rare but potentially catastrophic manifestation with a high mortality. Among rheumatologic diseases, it occurs most frequently in patients with systemic lupus erythematosus (SLE) and systemic vasculitis. Despite new diagnostic tools and therapies, it remains a diagnostic and therapeutic challenge. The aim of this work was to characterize the SLE patients with an episode of alveolar hemorrhage followed in our Clinical Immunology Unit (CIU). A retrospective chart review was carried out for all patients with SLE followed in CIU between 1984 and the end of 2013. We reviewed the following data: demographic characteristics, clinical and laboratory data, radiologic investigations, histologic studies, treatment, and outcome. We identified 10 episodes of DAH, corresponding to seven patients, all female. These represent 1.6% of SLE patients followed in our Unit. The age at DAH attack was 42.75 ± 18.9 years. The average time between diagnosis of SLE and the onset of DAH was 7.1 years. Three patients had the diagnosis of SLE and the DAH attack at the same time. Disease activity according to SLEDAI was high, ranging from 15 to 41. All patients were treated with methylprednisolone, 37.5% cyclophosphamide and 28.6% plasmapheresis. The overall mortality rate was 28.6%.

  16. Alveolar Subphase pH in the Lungs of Anesthetized Rabbits

    Science.gov (United States)

    Nielson, D. W.; Goerke, J.; Clements, J. A.

    1981-11-01

    We measured the pH of the alveolar subphase fluid by puncturing the most superficial alveoli of the exposed lungs of anesthetized rabbits with H+-selective and nonselective KCl microelectrodes. In these experiments, we bathed the lung surface with paraffin oil or buffered Ringer's solutions that had a CO2 tension of 40 Torr (1 Torr = 133.3 Pa) and found an alveolar pH of 6.92± 0.01 (mean ± SEM). When the pH of the surface buffer was below 6.7 or above 7.5, alveolar pH varied with surface buffer pH. With the nonselective electrode, we did not find a significant electrical potential difference between the alveolar fluid and the pleural surface. These results are consistent with active transport of H+ (or HCO3-) across alveolar epithelium.

  17. A contemporary perspective on techniques for the clinical assessment of alveolar bone

    Energy Technology Data Exchange (ETDEWEB)

    Hausmann, E. (State Univ. of New York, Buffalo (USA))

    1990-03-01

    Radiographic techniques, traditional ones as well as newer ones under development, for clinically assessing alveolar bone are critically assessed. Traditional intraoral radiography is reexamined, in particular with regard to the accuracy with which the alveolar crest is seen. Evidence is presented for a more accurate representation of the alveolar crest on bitewings rather than periapical films. Application in periodontics of newer radiographic techniques, subtraction radiography, and single and dual photon aborptiometry presently under clinical development are discussed in regard to their potential and limitations. Similarly, radiopharmaceuticals to evaluate the metabolic status of alveolar bone are discussed as well as the potential for using analyses of gingival crevice fluid as a window for assessment of alveolar crest metabolism. 46 references.

  18. Imaging of the three-dimensional alveolar structure and the alveolar mechanics of a ventilated and perfused isolated rabbit lung with Fourier domain optical coherence tomography

    Science.gov (United States)

    Popp, Alexander; Wendel, Martina; Knels, Lilla; Koch, T.; Koch, Edmund

    2006-01-01

    In this feasibility study, Fourier domain optical coherence tomography (FDOCT) is used for visualizing the 3-D structure of fixated lung parenchyma and to capture real-time cross sectional images of the subpleural alveolar mechanics in a ventilated and perfused isolated rabbit lung. The compact and modular setup of the FDOCT system allows us to image the first 500 µm of subpleural lung parenchyma with a 3-D resolution of 16×16×8 µm (in air). During mechanical ventilation, real-time cross sectional FDOCT images visualize the inflation and deflation of alveoli and alveolar sacks (acini) in successive images of end-inspiratory and end-expiratory phase. The FDOCT imaging shows the relation of local alveolar mechanics to the setting of tidal volume (VT), peak airway pressure, and positive end-expiratory pressure (PEEP). Application of PEEP leads to persistent recruitment of alveoli and acini in the end-expiratory phase, compared to ventilation without PEEP where alveolar collapse and reinflation are observed. The imaging of alveolar mechanics by FDOCT will help to determine the amount of mechanical stress put on the alveolar walls during tidal ventilation, which is a key factor in understanding the development of ventilator induced lung injury (VILI).

  19. Analisi dei processi di un ambulatorio per i viaggiatori internazionali

    Directory of Open Access Journals (Sweden)

    M.L. Demarchi

    2003-05-01

    materiale informativo anche in lingua straniera. L’analisi ha inoltre rilevato l’assenza di un sistema informativo di feed-back che consentisse il monitoraggio della morbosità delle patologie contratte all’estero, elemento utile in un’ottica di programmazione.

    Conclusioni: l’ABC, grazie all’individuazione delle criticità, ha
    consentito di definire un piano per la riorganizzazione dell’ambulatorio, volto all’ottimizzazione delle risorse disponibili garantendo l’erogazione di prestazioni efficaci ed efficienti.

  20. ANALISIS BANTUAN KREDIT TERHADAP PERKEMBANGAN KELOMPOK USAHA BERSAMA

    Directory of Open Access Journals (Sweden)

    Priyo Harsono

    2012-09-01

    Full Text Available The object of research is KUB Rukun Mina Barokah in Juwana, Pati. The purpose of research is to investigate the differences of KUB Rukun Mina Barokah development before and after getting the credit assistance from the Department of Marine and Fisheries, Pati in terms of capital, labor, thenumber of buyers, the total sales, and profits. The population for this research is 45 small micro enterprises. The type of data collected are primary and secondary data. The methods of data analysis are validity test, reliability test, and Wilcoxon sign rank test statistics. Based on the results of Wilcoxon sign rank test statistics which focuses on the variables of capital, labor, number of buyers, total sales and profit , it is obtained that p-value is 0.000 (0.000 <0,05. It shows that the credit assistance of the Department of Marine and Fisheries, Pati has given the changes in the joint venture group, Rukun Mina Barokah. The changes here means an increase in the variables before and after getting the credit assistance. Therefore, besides financial aid in the form of business loans, collaboration expansion is also needed to develop the business groups (KUB Objek dalam penelitian ini adalah KUB Rukun Mina Barokah di Kecamatan Juwana Kabupaten Pati. Tujuan penelitian ini untuk mengetahui perbedaan perkembangan KUB Rukun Mina Barokah sebelum dan sesudah mendapatkan bantuan kredit dari Dinas Kelautan dan Perikanan Kabupaten Pati ditinjau dari modal usaha, tenaga kerja, jumlah pembeli, total penjualan, dan keuntungan. Populasi penelitian sebanyak 45 usaha mikro kecil.Jenis datanya adalah data primer dan data sekunder.Metode analisis data meliputi uji validitas, uji reabilitas, dan uji statistic pangkat tanda wilcoxon.Berdasarkan hasil uji statistik pangkat tanda wilcoxon, baik variabel modal usaha, variabel tenaga kerja,variabel jumlah pembeli, variabel total penjualan maupun variabel keuntungan didapatkan nilai -p sebesar 0,000 (0,000 < 0,05. Hal itu

  1. ANALISIS METODE KARMARKAR UNTUK MENYELESAIKAN MASALAH PROGRAM LINIER

    Directory of Open Access Journals (Sweden)

    DR Indriani

    2014-06-01

    Full Text Available Penelitian ini bertujuan mengetahui dasar matematis dalam metode Karmarkar, mengetahui penyelesaian masalah program linier dengan metode Karmarkar, serta menganalisis penyelesaian masalah program linier dengan metode simpleks dan metode Karmarkar. Penelitian ini dilakukan dengan studi literatur. Penyelesaian program linier dengan metode Karmarkar, mula-mula harus diubah dalam bentuk kanonik Karmarkar, kemudian diselesaikan dengan metode Karmarkar. Penyelesaian program linier dengan metode Karmarkar dilakukan secara manual dan dengan menggunakan program Matlab, kemudian hasil dari keduanya dilakukan analisis. Kesimpulannya adalah bahwa metode Karmarkar adalah suatu metode titik interior yang menembus dari daerah fisibel untuk mencapai suatu solusi optimum sedangkan metode simpleks bergerak dari titik ekstrim menuju ke penyelesain optimum. Titik interior dilambangkan dengan banyaknya variabel. Menyelesaikan masalah dengan metode Karmarkar yaitu dengan mengubah bentuk dasar program linier ke bentuk kanonik Karmarkar, dilanjutkan dengan perhitungan iterasi hingga nilai  minimum (kanonik Karmarkar kurang dari 0,05. Metode Karmarkar membutuhkan perhitungan yang relatif lebih besar untuk persoalan program linier yang berukuran kecil dan lebih cepat diselesaikan dengan metode simpleks, sedangkan untuk kendala yang lebih besar metode Karmarkar lebih efisien dibandingkan metode simpleks. This research purpose is to determine the basic mathematical Karmarkarmethods, to know the solving linear programs with Karmarkar method, and to analyze the problem solving linear program with the simplex method and Karmarkar method. This research was literature study. The completion of linear programs with Karmarkar method was done manually by using Matlab program, then the results of both was analyzed. The conclusion is the Karmarkar method is a method that penetrates the interior point of the feasible region to achieve an optimum solution while the simplex method

  2. Analisis Hubungan Ekspor, Impor, PDB dan Utang Luar Negeri Indonesia Periode 1970-2013

    Directory of Open Access Journals (Sweden)

    Dison M.H. Batubara

    2015-11-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui ada tidaknya hubungan kausalitas serta kointegrasi di antara ekspor, impor, PDB dan utang luar negeri Indonesia dengan memakai data sekunder time series tahun 1970-2013. Penelitian ini menerapkan metode Vector Autoregression (VAR yang meliputi Granger-Causality test dan Johansen Co-Integration test, yang dilanjutkan dengan estimasi Vector Error Correction Model (VECM dan forecasting melalui analisis Impulse Response Function (IRF dan Forecast Error Variance Decomposition (FEVD. Hasil uji Granger-Causality menunjukkan diantara keempat variabel tidak terdapat kausalitas, namun terdapat lima hubungan satu arah (unidirectional, yang meliputi ekspor ke impor, ekspor ke utang luar negeri, PDB ke impor, impor ke utang luar negeri dan PDB ke utang luar negeri. Johansen Co-Integration test menunjukkan bahwa keempat variabel terkointegrasi. Analisis IRF dan FEVD menunjukkan bahwa variabel yang paling berpengaruh terhadap ekspor, impor dan PDB adalah ekspor, sedangkan variabel yang paling berpengaruh terhadap utang luar negeri adalah impor

  3. Analisi basata sugli sforzi locali della resistenza a fatica di giunzioni incollate di materiali compositi

    Directory of Open Access Journals (Sweden)

    F. Moroni

    2009-07-01

    Full Text Available Il lavoro prende spunto dai risultati di un’analisi sperimentale del comportamento a fatica di giunzioni incollate di materiali compositi laminati di elevato spessore formati da strati di unidirezionale e di tessuto di fibra di carbonio. I giunti sono stati realizzati in modo tale da saggiare l’influenza della lunghezza di sovrapposizione (da 25,4 mm a 110,8 mm, della forma del giunto (con e senza rastremazione, e della composizione degli aderendi (sostituzione di uno degli aderendi in composito con uno in acciaio. Mediante analisi 2D elastiche con il metodo degli elementi finiti sono state ricavate le distribuzioni degli sforzi all’interno dello strato di adesivo, al fine di individuare un parametro utile alla descrizione del comportamento a fatica in termini di sforzi locali - numero di cicli a rottura. Il ruolo della fase di propagazione viene discusso alla luce di osservazioni dell’avanzamento della frattura, condotta su alcuni dei giunti testati.

  4. Analisis perilaku dinamik pada sel T CD4+ dan sel T CD8+ terhadap infeksi mikobakterium

    Directory of Open Access Journals (Sweden)

    Alfi Nur Rochmatin

    2014-05-01

    Full Text Available Model matematika pada infeksi mikobakterium tuberkulosis yang berbentuk sistem persamaan diferensial nonlinear orde satu. Penelitian ini telah mengkonstruksi model matematika pada interaksi makrofag, sel T CD4+ dan sel T CD8+ dengan pengaruh usia. Solusi numerik pada model matematika ini dengan menggunakan ODE 45 berbantuan matlab. Analisis kestabilan diamati melalui titik tetap dengan mencari matriks jacobian dan nilai eigen dari titik tetap tersebut, maka dapat diperoleh bahwa semua titik tetap tersebut tidak stabil. Berdasarkan analisis perilaku dinamik pada sel T CD4+ dan sel T CD8+pada usia muda dan usia tua maka akan diperoleh bahwa sel T CD4+dan sel T CD8+ lebih banyak mempengaruhi populasi bakteri mikobakterium tuberkulosis dari pada saat usia muda

  5. Inhibition of immunological function mediated DNA damage of alveolar macrophages caused by cigarette smoke in mice.

    Science.gov (United States)

    Ishida, Takahiro; Hirono, Yuriko; Yoshikawa, Kenichi; Hutei, Yoshimi; Miyagawa, Mayuko; Sakaguchi, Ikuyo; Pinkerton, Kent E; Takeuchi, Minoru

    2009-12-01

    Exposure to cigarette smoke impairs the pulmonary immune system, including alveolar macrophage function, although the mechanisms by which this occurs are not fully elucidated. This study investigates the effect of cigarette smoke exposure on the antigen-presenting activity of alveolar macrophages, which is required for antigen-specific response to T cells. C57BL/6 mice were exposed to cigarette smoke for 10 days using a Hamburg II smoking machine, and alveolar macrophages were obtained by bronchoalveolar lavage. The antigen-presenting activity of alveolar macrophages was significantly inhibited in mice exposed to cigarette smoke compared with mice not exposed to cigarette smoke. Major histocompatibility complex class II cell surface molecule-positive cells, B7-1 molecule-positive cells, and interleukin-1beta messenger RNA gene expression in alveolar macrophages were significantly decreased in mice exposed to cigarette smoke compared with mice not exposed to cigarette smoke. In contrast, DNA damage and generation of superoxide and hydrogen peroxide in alveolar macrophages were significantly increased by cigarette smoke exposure. These results suggest that inhibition of the antigen-presenting activity of alveolar macrophages may result from decreased expression of major histocompatibility complex class II and B7-1 molecules and interleukin-1beta messenger RNA gene expression following cigarette smoke exposure. Furthermore, inhibition of antigen presentation in alveolar macrophage may result from DNA damage induced by excessive amounts of reactive oxygen species being generated by alveolar macrophages following cigarette smoke exposure. These findings suggest that cigarette smoke impairs the immunological function of alveolar macrophages and, as a result, increases the risk for pulmonary infection. PMID:19922407

  6. Clinical study of the alveolar bone height for the dental implant using preoperative computed tomographic examination

    International Nuclear Information System (INIS)

    CT examination is useful for preoperative dental implant, and many studies of concerning clinical studies using CT images have been reported. However, there are few reports comparing alveolar bone heights among age groups of many cases. The purpose of this study was to evaluate the clinical studies of preoperative CT examinations for alveolar bone heights and patient ages at our department of radiology using 64 multi-detector row CT. The subjects consisted of 5174 regions in 1312 (425 males and 887 females, mean age 55.5 yrs, 16-86 yrs) cases of preoperative CT examinations, between April 2006 and December 2007. CT machine used was the Aquilion TM64 (Toshiba Medical Systems, Japan), and the workstation used was the ZIOSTATION (ZIOSOFT, Japan). All of CT examinations were performed the position of implant placement and disease examined from CT findings. Alveolar bone heights for dental implants were examined from the CT images. For the maxilla, the alveolar bone height was the distance from the alveolar crest to the base of the nasal cavity, or the base of the maxillary sinus. For the mandible, the alveolar bone height is the distance from the alveolar crest and the upper wall of the mandibular canal, or the distance between the alveolar crest and inferior border of mandible. The numbers of the implant position were 955 site for the first molar of the mandible (the average alveolar bone height is 13.9 mm), 652 site for the second molar of the mandible (12.8 mm), and 567 site for the first molar of the maxilla (6.8 mm). In conclusion, the position where implant were to placed the most was the first molar of the mandible, and it's alveolar bone height got lower with age for women. It is over 60% of the maxillary molar area were lower 8 mm, so some kind of osteogenetic treatment was required in many cases, and hence we reassured the importance of CT. (author)

  7. Meta Analisis sa Pagsusuri ng Maiikling Kwento sa mga Tesis at Disertasyon

    OpenAIRE

    Regina I. Cuizon

    2014-01-01

    Anumang mga pagbabago na makikita sa mundo ay bunga ng pananaliksik. Ang meta-analisis ay isa sa mga bunga ng pananaliksik na ginagamit sa kasalukuyan bilang teknik upang malaman iba pang mga nagsulputang informasyon. Ito’y pag-aaral sa mga pag-aaral. Isang kritikal at sistematikong pagsusuri sa istruktura ng mga pag-aaral. Maging gabay sa mga gradwadong paaralan sa pagpili ng paksang pagaaralan. Pangunahing layunin na matiyak ang mga pamamaraan sa pagsusuri ng maiikling kwento ng...

  8. ANALISIS HEDONIC TERHADAP HARGA JUAL MOBIL TOYOTA KIJANG BEKAS DI SURABAYA

    Directory of Open Access Journals (Sweden)

    Guntur Martono

    2000-01-01

    Full Text Available The factors influencing the price of used Toyota Kijang vehicles in Surabaya were evaluated using a hedonic model. Regression analysis was used to estimate the size of the influence of the hedonic characterics which determine used Kijang prices. Based on the results, it can be concluded that the year the vehicle was made, the condition of the engine, the condition of the body, the condition of tires, the presence of air conditioner, and the GX and SX types all have a positive and significant relationship with the selling price. The value of R2 is 0,951 and the value of the F test is significant. The results of forecasting analysis show that the above analysis is correct, since the difference between the forecast price and the actual price varies between 1.2% - 4.5%. Abstract in Bahasa Indonesia : Faktor-faktor yang mempengaruhi harga mobil niaga Toyota Kijang bekas di Surabaya diteliti dengan menggunakan model hedonic. Analisis regresi digunakan untuk menghitung besarnya pengaruh karakteristik hedonic yang menentukan harga mobil Kijang bekas. Dari hasil analisis, dapat disimpulkan bahwa tahun pembuatan, kondisi mesin, kondisi bodi, kondisi ban, air conditioner, tipe GX dan tipe SX berhubungan positif dan signifikan terhadap harga jual. Nilai R2 menjadi sebesar 0,951 dan nilai uji F signifikan. Hasil analisis peramalan membuktikan bahwa analisis di atas tepat karena perselisihan antara harga peramalan dan harga sebenarnya berkisar antara 1,2% - 4,5%. Kata kunci: model hedonic, regresi berganda, variabel dummy, harga mobil bekas, Toyota Kijang

  9. Analisis Faktor-Faktor Yang Mempengaruhi Price Earning Ratio Pada Perusahaan LQ45 Di Indonesia

    OpenAIRE

    Hutagalung, Pretty N

    2010-01-01

    Pretty. N. Hutagalung (2010). Analisis Faktor-Faktor yang Mempengaruhi Price Earning Ratio pada Perusahaan LQ45 di Indonesia. Pembimbing, Dr. Isfenti Sadalia, SE, ME. Ketua Departemen, Prof. Dr. Ritha F. Dalimunthe, SE, M.Si. Penguji, Drs. Syahyunan, M.Si dan Drs. Nakman Harahap, Msi. (Penguji I dan Penguji II). Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh Dividend Payout Ratio, Earning Growth, Debt to Equity Ratio dan Return on Equity terhadap Price Earning Ratio pada...

  10. Analisis Perkembangan Usaha Home Industry Makanan dan Minuman di Kota Binjai

    OpenAIRE

    Muharoma, Fadhlun Wirizkho

    2016-01-01

    This research which titled "Analisis Perkembangan Usaha Home Industry Makanan dan Minuman di Kota Binjai " aims to determine the internal factors that consist of strengths and weaknesses, as well as external factors which consist of the opportunities and threats of home industry business development strategies in Binjai. The data used are primary data and secondary data. Primary data were obtained from questionnaires by speakers, namely home business operators in the food and beverage industr...

  11. REPRESENTASI EKSISTENSI DIRI PADA PROFILE PICTURE DALAM SITUS PERTEMANAN FACEBOOK (Sebuah Analisis Semiotika)

    OpenAIRE

    LA???LANG, RAKHMAWATY

    2012-01-01

    RAKHMAWATY LA???LANG, E31107072. Representasi Eksistensi Diri pada Profile Picture dalam Situs Pertemanan Facebook (Analisis Semiotika). (dibimbing M. Farid dan Alem Febri Sonni). Tujuan penelitian ini adalah: 1. Untuk mengetahui bagaimana eksistensi seseorang dihadirkan dalam Profile Picture pada situs pertemanan melalui penelitian terhadap semua unsur tanda yaitu ikon, indeks, dan simbol. 2. Untuk mengetahui representasi eksistensi diri dalam Profile Picture pada Facebook. Penelitian me...

  12. Analisis Semiotika Makna Pesan pada Iklan Axis Versi “Iritologi – Menatap Masa Depan”

    OpenAIRE

    Puri Sulistiyawati

    2016-01-01

    Abstrak Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis makna pesan dalam iklan Axis versi “Iritologi – Menatap masa depan” di televisi dengan menggunakan pendekatan semiotika Roland Barthes. Dari analisis yang telah dilakukan berdasarkan makna denotasi, konotasi dan mitos dalam iklan Axis versi “iritologi – Menatap masa depan”, dapat diketahui bahwa iklan Axis memiliki konsep yang sangat sederhana, dengan mengusung tema tentang kebiasaan remaja dalam memanfaatkan media s...

  13. Productividad del trabajo en la industria maquiladora del norte de Mexico: Un analisis de convergencia

    OpenAIRE

    Jorge Eduardo Mendoza Cota

    2004-01-01

    En este estudio se analiza la productividad del trabajo en la industria maquiladora de exportacion por divisiones y por estados, comparando la region de la frontera norte de Mexico con el resto de los estados. Se utiliza un analisis econometrico de panel, partiendo del enfoque de convergencia condicional. Se aprecia una heterogeneidad de la productividad del trabajo, lo que sugiere diferencias regionales en los procesos tecnologicos y en la dotacion del capital. Los estados del centro mostrar...

  14. L’analisi dell’attività onirica secondo l’approccio cognitivo - neuropsicologico

    Directory of Open Access Journals (Sweden)

    Nicola Allegri

    2012-09-01

    Full Text Available Un’analisi fenomenologica del sogno apre il quadro delle indagini scientifiche sull’attività onirica e consente a differenti discipline di integrare le rispettive conoscenze empiriche sull’argomento. In questo lavoro, a partire da una visione fenomenologica ed ermeneutica dell’essere umano (essere-nel-mondo, cercheremo di delineare alcuni aspetti della struttura onirica, facendo dialogare tra loro alcune evidenze empiriche sull’argomento che provengono sia dalle scienze umane, sia dalle neuroscienze.

  15. ANALISIS FISIS MEMBRAN BIOFILTER ROKOK DENGAN VARIASI DAUN, BIJI DAN KULIT DELIMA

    OpenAIRE

    Umaiyatus Syarifah; Ririn Mega S; Muthmainnah; Agus Mulyono

    2015-01-01

    Analisis fisis membrane biofilter rokok telah dilakukan untuk mengetahui kerapatan dan porositas. Membrane biofilter terbuat dari variasi daun delima, biji delima dan kulit delima. Variasi massa yang digunakan pada masing-masing bahan delima adalah 0.7 gram, 0.8 gram, 0.9 gram dan 1 gram. Matriks yang digunakan pada pembuatan biofilter berbahan delima adalah polyethilene glikol (PEG). Data pengujian kerapatan membran pada biofilter berbahan daun delima terbesar adalah 1.532 g/cm3 dengan kompo...

  16. Analisis Customer Relationship Management Terhadap Kepuasan Nasabah Pada Customer Care Bank CIMB Niaga Makassar

    OpenAIRE

    Ihsan Raya, Ahmad

    2013-01-01

    2013 Penelitian ini bertujuan untuk mengetahui pengaruh Customer Relationship management Continuity marketing, one to one marketing, dan partnering atau co-marketing terhadap kepuasan nasabah pada Customer Care Bank CIMB Niaga Makassar dan untuk mengetahui variabel dari Customer Relationship yang paling dominan berpengaruh terhadap kepuasan nasabah pada Customer Care Bank CIMB Niaga Makassar. Untuk mencapai tujuan tersebut maka digunakan metode analisis deskriptif, uji kelayakan instrument...

  17. ANALISIS KINERJA KEUANGAN PT BANK SULSELBAR DENGAN MENGGUNAKAN ECONOMIC VALUE ADDED (EVA)

    OpenAIRE

    Asmiati, -

    2012-01-01

    ASNIATI, A21108323. Analisis Kinerja Keuangan PT Bank Sul-Selbar Dengan Menggunakan Economic Value Added (EVA). (Dibimbing Oleh Prof.Dr.H Syamsu Alam SE, M.si dan Drs Mukhtar M.si) PT Bank Sul-selbar merupakan perusahaan perbankan yang Menjadi Bank terbaik di Kawasan Indonesia Timur dengan dukungan manajemen dan sumber daya manusia yang profesional serta memberikan nilai tambah kepada Pemda dan masyarakat. Penelitian ini ber...

  18. Analisis Pengaruh Ekspor Sektor Industri Dan Penanaman Modal Asing Sektor Industri Terhadap Pertumbuhan Ekonomi Indonesia

    OpenAIRE

    Fahmi Hasbullah

    2009-01-01

    Penelitian ini berjudul “Analisis Pengaruh Ekspor Sektor Industri dan Penanaman Modal Asing Sektor Industri terhadap Pertumbuhan Ekonomi Indonesia”. Dalam kasus ini, Pertumbuhan Ekonomi Indonesia adalah variabel terikat. Perdagangan Internasional yang terdiri dari Ekspor dan Impor adalah variabel bebas. Tujuan penelitian ini adalah untuk menjelaskan pengaruh variabel bebas terhadap variabel terikat. Penelitian ini menggunakan data sekunder atau data periode waktu sejak 1987 sampai 2006. Da...

  19. Analisis Kata Penghubung He (和), Gen ( 跟) Dan Yu (与) Dalam Kalimat Bahasa Mandarin

    OpenAIRE

    Tarigan, Cicilia Aprilina Kartika

    2013-01-01

    The tittle of this paper is “Analisis Kata Penghubung He, Gen, dan Yu dalam Kalimat Bahasa Mandarin. Researcher analyzes the use of Chinese cunjuctions, he, gen, yu in Chinese sentences. Actually he, gen and yu have the same meaning but differently in their own characteristics. The concepts of the thesis are The methodology on the thesis is descriptive method. The author analyze about characteristic and similarities and differences of cunjuctions, hen, gen, and yu. By this, author is try to ...

  20. Analisis Penempatan Terhadap Kinerja Karyawan pada PT. Perkebunan Nusantara III Medan

    OpenAIRE

    Yuni Ramadhani Nasution

    2008-01-01

    ABSTRAK Yuni Ramadhani Nst (2006), Analisis Penempatan Terhadap Kinerja Karyawan pada PT. Perkebunan Nusantara III Medan, dibawah bimbingan Prof. Dr. Ritha F. Dalimunthe, SE, MSi selaku Ketua Departemen, Drs. Chairuddin Nst selaku Dosen Pembimbing, Dra, Ramona RI Hasibuan, MRP selaku Dosen Penguji I dan Dra, Nurbayati Siregar, MSi selaku Dosen Penguji II. Penelitian ini bertujuan mengetahui adanya pengaruh komunikasi terhadap kinerja karyawan pada PT. Perkebunan Nusantara III Medan . Pe...

  1. ANALISIS KARAKTERISASI VIBRASI MOLEKUL SENYAWA ORGANIK FENOL, ASAM AKSALAT DAN ETIL ASETAT SECARA SPEKTOSKOPI INFRA MERAH

    OpenAIRE

    Bannu, S.Si., M.Si.

    2005-01-01

    Telah dilakukan penelitian Analisis Karakterisasi Vibrasi Melekul Senayawa Organik Fenol, Asam Oksalat dan Etil Asetat. Hasil Penelitian yang diamati : 1) frekuensi serapan vibrasi untuk masing-masing ikatan antar atom pada molekul Fenol, Asam Oksalat dan Etil Asetat; 2) konstanta gaya pada molekul Fenol, Asam Oksalat dan Etil Asetat; 3) panjang ikatan antar Atom; 4) konstanta tak harmonik ikatan antar atom; dan 5) energi disosiasi iktan antar atom. Karakterisasi dari ke tiga senyawa men...

  2. ANALISIS DAN PEMODELAN PROSES BISNIS PROSEDUR PELAKSANAAN PROYEK AKHIR SEBAGAI ALAT BANTU IDENTIFIKASI KEBUTUHAN SISTEM

    Directory of Open Access Journals (Sweden)

    Siska Komala Sari

    2015-11-01

    Full Text Available Proyek Akhir (PA adalah mata kuliah yang diajukan untuk memenuhi persyaratan studi Diploma di suatu Perguruan Tinggi. Mata kuliah ini dilaksanakan pada Semester 6 (enam atau tingkat akhir dari perkuliahan studi Diploma. Sebuah proses bisnis dapat dijelaskan dengan sederhana sebagai aliran aktifitas kegiatan. Proses bisnis adalah kumpulan dari tugas atau aktivitas yang terstruktur yang dapat menghasilkan layanan atau produk tertentu untuk satu atau banyak konsumen. Pada penelitian ini dilakukan analisis dan pemodelan proses bisnis dalam pelaksanaan proyek akhir. Hasil analisis dan pemodelan proses bisnis ini digunakan untuk memperbaiki alur kerja dan sebagai dasar pengembangan sistem informasi manajemen proyek akhir yang mampu mendukung alur pelaksanaan proyek akhir meliputi pengajuan topik, penentuan pembimbing, pelaksanaan seminar dan pelaksanaan sidang. Dalam analisa proses bisnis pelaksanaan proyek akhir ini kita dapat mengidentifikasi bahwa ada kasus yang dapat dimodelkan dengan BPMN (Business Process Modelling & Notation dan ada kasus yang cukup dimodelkan dengan notasi swimlanes s dimana masing-masing model memiliki kelebihan dan kekurangan masing-masing. Analisis dan pemodelan proses bisnis pelaksanaan proyek akhir ini dapat digunakan sebagai alat bantu untuk mengidentifikasi kebutuhan sistem

  3. ANALISIS TINGKAT KAPABILITAS SISTEM INFORMASI RUMAH SAKIT BERDASARKAN COBIT 5 (MEA01 PADA RSUD TUGUREJO SEMARANG

    Directory of Open Access Journals (Sweden)

    Ariel Bagus Nugroho

    2015-11-01

    Full Text Available RSUD Tugurejo Semarang merupakan Rumah Sakit kelas B milik pemerintah Provinsi Jawa Tengah yang menyediakan pelayanan jasa untuk masyarakat. Dalam manajemen pengolahan data, RSUD Tugurejo Semarang telah menggunakan sistem informasi rumah sakit. Untuk mengetahui apakah sistem informasi telah berjalan seperti yang diharapkan, maka perlu dilakukan analisis tatakelola teknologi informasi. Pada penelitian ini analisis tatakelola teknologi informasi berfokus pada proses pengawasan, evaluasi dan penilaian kinerja, dan kesesuaian kinerja teknologi informasi, yaitu domain MEA01 pada framework COBIT 5.Tujuan penelitian ini untuk mengetahui tingkat kapabilitas dan strategi perbaikan untuk proses pengawasan, evaluasi dan penilaian kinerja dan kesesuaian TI. Metode pengumpulan  data penelitian ini dengan menggunakan studi dokumen, kuesioner dan wawancara kemudian dianalisis tingkat kapabilitas dan kesenjangan. Tingkat kapabilitas yang didapat dari hasil penelitian yaitu berada level 2 (managed. Untuk menaikkan tingkat kapabilitas pada level 3 maka maka perlu dilakukan secara bertahap strategi perbaikan pada PA 2.1, PA2.2, PA 3.1, dan 3.2. Kata kunci: Analisis Tata Kelola TI, COBIT 5, MEA01, Tingkat Kapabilitas, Rumah Sakit.

  4. Risk analysis in the chemical industry; Analisis de riesgos en la industria quimica

    Energy Technology Data Exchange (ETDEWEB)

    Rea Soto, Rogelio; Sandoval Valenzuela, Salvador [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    2000-07-01

    The Instituto de Investigaciones Electricas has a group of risk analysis (GAR), specialized in the most advanced methodologies to apply them in diverse industries of the productive sector, such as the nuclear, the oil and the chemical industries. In this work the integrated methodology that the GAR uses to make risk analysis in the chemical and oil industries is described. These analyses have as an objective to make a meticulous evaluation of the system design, the operation practices, the maintenance and inspection policies and the emergency plans. [Spanish] El Instituto de Investigaciones Electricas cuenta con un grupo de analisis de riesgo (GAR), especializado en las metodologias mas avanzadas para aplicarlas en diversas industrias del sector productivo, como lo son la nuclear, la petrolera y la quimica. En este trabajo se describe la metodologia integrada que el GAR utiliza para realizar analisis de riesgos en las industrias quimica y petrolera. Estos analisis tienen como objetivo realizar una minuciosa evaluacion del diseno del sistema, las practicas de operacion, las politicas de mantenimiento e inspeccion y los planes de emergencia.

  5. An Optimised Human Cell Culture Model for Alveolar Epithelial Transport

    Science.gov (United States)

    Birch, Nigel P.; Suresh, Vinod

    2016-01-01

    Robust and reproducible in vitro models are required for investigating the pathways involved in fluid homeostasis in the human alveolar epithelium. We performed functional and phenotypic characterisation of ion transport in the human pulmonary epithelial cell lines NCI-H441 and A549 to determine their similarity to primary human alveolar type II cells. NCI-H441 cells exhibited high expression of junctional proteins ZO-1, and E-cadherin, seal-forming claudin-3, -4, -5 and Na+-K+-ATPase while A549 cells exhibited high expression of pore-forming claudin-2. Consistent with this phenotype NCI-H441, but not A549, cells formed a functional barrier with active ion transport characterised by higher electrical resistance (529 ± 178 Ω cm2 vs 28 ± 4 Ω cm2), lower paracellular permeability ((176 ± 42) ×10−8 cm/s vs (738 ± 190) ×10−8 cm/s) and higher transepithelial potential difference (11.9 ± 4 mV vs 0 mV). Phenotypic and functional properties of NCI-H441 cells were tuned by varying cell seeding density and supplement concentrations. The cells formed a polarised monolayer typical of in vivo epithelium at seeding densities of 100,000 cells per 12-well insert while higher densities resulted in multiple cell layers. Dexamethasone and insulin-transferrin-selenium supplements were required for the development of high levels of electrical resistance, potential difference and expression of claudin-3 and Na+-K+-ATPase. Treatment of NCI-H441 cells with inhibitors and agonists of sodium and chloride channels indicated sodium absorption through ENaC under baseline and forskolin-stimulated conditions. Chloride transport was not sensitive to inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) under either condition. Channels inhibited by 5-nitro-1-(3-phenylpropylamino) benzoic acid (NPPB) contributed to chloride secretion following forskolin stimulation, but not at baseline. These data precisely define experimental conditions for the application of NCI

  6. Hormonal regulation of alveolarization: structure-function correlation

    Directory of Open Access Journals (Sweden)

    Godinez Marye H

    2006-03-01

    Full Text Available Abstract Background Dexamethasone (Dex limits and all-trans-retinoic acid (RA promotes alveolarization. While structural changes resulting from such hormonal exposures are known, their functional consequences are unclear. Methods Neonatal rats were treated with Dex and/or RA during the first two weeks of life or were given RA after previous exposure to Dex. Morphology was assessed by light microscopy and radial alveolar counts. Function was evaluated by plethysmography at d13, pressure volume curves at d30, and exercise swim testing and arterial blood gases at both d15 and d30. Results Dex-treated animals had simplified lung architecture without secondary septation. Animals given RA alone had smaller, more numerous alveoli. Concomitant treatment with Dex + RA prevented the Dex-induced changes in septation. While the results of exposure to Dex + RA were sustained, the effects of RA alone were reversed two weeks after treatment was stopped. At d13, Dex-treated animals had increased lung volume, respiratory rate, tidal volume, and minute ventilation. On d15, both RA- and Dex-treated animals had hypercarbia and low arterial pH. By d30, the RA-treated animals resolved this respiratory acidosis, but Dex-treated animals continued to demonstrate blood gas and lung volume abnormalities. Concomitant RA treatment improved respiratory acidosis, but failed to normalize Dex-induced changes in pulmonary function and lung volumes. No differences in exercise tolerance were noted at either d15 or d30. RA treatment after the period of alveolarization also corrected the effects of earlier Dex exposure, but the structural changes due to RA alone were again lost two weeks after treatment. Conclusion We conclude that both RA- and corticosteroid-treatments are associated with respiratory acidosis at d15. While RA alone-induced changes in structure andrespiratory function are reversed, Dex-treated animals continue to demonstrate increased respiratory rate, minute

  7. Alveolar stability under different combinations of positive end-expiratory pressure and tidal volume: alveolar microscopy in isolated injured rat lungs

    Institute of Scientific and Technical Information of China (English)

    LIU Hui; Claudius A. Stahl; Knut Moeller; Matthias Schneider; Steven Ganzert; ZHAO Zhan-qi; TONG Xiao-wen; Josef Guttmann

    2010-01-01

    Background High positive end-expiratory pressure (PEEP) and low tidal volume (VT) ventilation is thought to be a protective ventilation strategy. It is hypothesized that the stabilization of collapsible aiveoli during expiration contributes to lung protection. However, this hypothesis came from analysis of indirect indices like the analysis of the pressure-volume curve of the lung. The purpose of this study was to investigate isolated healthy and injured rat lungs by means of alveolar microscopy, in which combination of PEEP and VI- is beneficial with respect to alveolar stability (I-E%).Methods Alveolar stability was investigated in isolated, non-perfused mechanically ventilated rat lungs. Injured lungs were compared with normal lungs. For both groups three PEEP settings (5, 10, 20 cmH_2O) were combined with three VT settings (6, 10, 15 ml/kg) resulting in nine PEEP-VT combinations per group. Analysis was performed by alveolar microscopy.Results In normal lungs alveolar stability persisted in all PEEP-VT combinations (I-E% (3.2±11.0)%). There was no significant difference using different settings (P >0.01). In contrast, alveoli in injured lungs were extremely instable at PEEP levels of 5 cmH_2O (mean I-E% 100%) and 10 cmH_2O (mean I-E% (30.7±16.8)%); only at a PEEP of 20 cmH_2O were alveoli stabilized (mean I-E% of (0.2±9.3)%).Conclusions In isolated healthy lungs alveolar stability is almost unaffected by different settings of PEEP and VT. In solated injured lungs only a high PEEP level of 20 cmH_2O resulted in stabilized alveoli whereas lower PEEP levels are associated with alveolar instability.

  8. Particle-induced indentation of the alveolar epithelium caused by surface tension forces.

    Science.gov (United States)

    Mijailovich, S M; Kojic, M; Tsuda, A

    2010-10-01

    Physical contact between an inhaled particle and alveolar epithelium at the moment of particle deposition must have substantial effects on subsequent cellular functions of neighboring cells, such as alveolar type-I, type-II pneumocytes, alveolar macrophage, as well as afferent sensory nerve cells, extending their dendrites toward the alveolar septal surface. The forces driving this physical insult are born at the surface of the alveolar air-liquid layer. The role of alveolar surfactant submerging a hydrophilic particle has been suggested by Gehr and Schürch's group (e.g., Respir Physiol 80: 17-32, 1990). In this paper, we extended their studies by developing a further comprehensive and mechanistic analysis. The analysis reveals that the mechanics operating in the particle-tissue interaction phenomena can be explained on the basis of a balance between surface tension force and tissue resistance force; the former tend to move a particle toward alveolar epithelial cell surface, the latter to resist the cell deformation. As a result, the submerged particle deforms the tissue and makes a noticeable indentation, which creates unphysiological stress and strain fields in tissue around the particle. This particle-induced microdeformation could likely trigger adverse mechanotransduction and mechanosensing pathways, as well as potentially enhancing particle uptake by the cells. PMID:20634359

  9. Identification of molecular markers related to human alveolar bone cells and pathway analysis in diabetic patients.

    Science.gov (United States)

    Sun, X; Ren, Q H; Bai, L; Feng, Q

    2015-10-28

    Alveolar bone osteoblasts are widely used in dental and related research. They are easily affected by systemic diseases such as diabetes. However, the mechanism of diabetes-induced alveolar bone absorption remains unclear. This study systematically explored the changes in human alveolar bone cell-related gene expression and biological pathways, which may facilitate the investigation of its mechanism. Alveolar bone osteoblasts isolated from 5 male diabetics and 5 male healthy adults were cultured. Total RNA was extracted from these cells and subjected to gene microarray analysis. Differentially expressed genes were screened, and a gene interaction network was constructed. An enrichment pathway analysis was simultaneously performed on differentially expressed genes to identify the biological pathways associated with changes in the alveolar bone cells of diabetic humans. In total, we identified 147 mRNAs that were differentially expressed in diabetic alveolar bone cells (than in the normal cells; 91 upregulated and 36 downregulated mRNAs). The constructed co-expression network showed 3 pairs of significantly-expressed genes. High-enrichment pathway analysis identified 8 pathways that were affected by changes in gene expression; three of the significant pathways were related to metabolism (inositol phosphate metabolism, propanoate metabolism, and pyruvate metabolism). Here, we identified a few potential genes and biological pathways for the diagnosis and treatment of alveolar bone cells in diabetic patients.

  10. VEGF and endothelium-derived retinoic acid regulate lung vascular and alveolar development.

    Science.gov (United States)

    Yun, Eun Jun; Lorizio, Walter; Seedorf, Gregory; Abman, Steven H; Vu, Thiennu H

    2016-02-15

    Prevention or treatment of lung diseases caused by the failure to form, or destruction of, existing alveoli, as observed in infants with bronchopulmonary dysplasia and adults with emphysema, requires understanding of the molecular mechanisms of alveolar development. In addition to its critical role in gas exchange, the pulmonary circulation also contributes to alveolar morphogenesis and maintenance by the production of paracrine factors, termed "angiocrines," that impact the development of surrounding tissue. To identify lung angiocrines that contribute to alveolar formation, we disrupted pulmonary vascular development by conditional inactivation of the Vegf-A gene during alveologenesis. This resulted in decreased pulmonary capillary and alveolar development and altered lung elastin and retinoic acid (RA) expression. We determined that RA is produced by pulmonary endothelial cells and regulates pulmonary angiogenesis and elastin synthesis by induction of VEGF-A and fibroblast growth factor (FGF)-18, respectively. Inhibition of RA synthesis in newborn mice decreased FGF-18 and elastin expression and impaired alveolarization. Treatment with RA and vitamin A partially reversed the impaired vascular and alveolar development induced by VEGF inhibition. Thus we identified RA as a lung angiocrine that regulates alveolarization through autocrine regulation of endothelial development and paracrine regulation of elastin synthesis via induction of FGF-18 in mesenchymal cells. PMID:26566904

  11. Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation

    Directory of Open Access Journals (Sweden)

    Chen Yao

    2012-01-01

    Full Text Available Abstract Background Distal alveolar morphogenesis is marked by differentiation of alveolar type (AT-II to AT-I cells that give rise to the primary site of gas exchange, the alveolar/vascular interface. Endothelial-Monocyte Activating Polypeptide (EMAP II, an endogenous protein with anti-angiogenic properties, profoundly disrupts distal lung neovascularization and alveolar formation during lung morphogenesis, and is robustly expressed in the dysplastic alveolar regions of infants with Bronchopulmonary dysplasia. Determination as to whether EMAP II has a direct or indirect affect on ATII→ATI trans-differentiation has not been explored. Method In a controlled nonvascular environment, an in vitro model of ATII→ATI cell trans-differentiation was utilized to demonstrate the contribution that one vascular mediator has on distal epithelial cell differentiation. Results Here, we show that EMAP II significantly blocked ATII→ATI cell transdifferentiation by increasing cellular apoptosis and inhibiting expression of ATI markers. Moreover, EMAP II-treated ATII cells displayed myofibroblast characteristics, including elevated cellular proliferation, increased actin cytoskeleton stress fibers and Rho-GTPase activity, and increased nuclear:cytoplasmic volume. However, EMAP II-treated cells did not express the myofibroblast markers desmin or αSMA. Conclusion Our findings demonstrate that EMAP II interferes with ATII → ATI transdifferentiation resulting in a proliferating non-myofibroblast cell. These data identify the transdifferentiating alveolar cell as a possible target for EMAP II's induction of alveolar dysplasia.

  12. Hepatic alveolar echinococcosis: correlative US and CT study

    Energy Technology Data Exchange (ETDEWEB)

    Didier, D.; Weiler, S.; Rohmer, P.; Lasseque, A.; Deschamps, J.P.; Vuitton, D.; Miguet, J.P.; Weill, F.

    1985-01-01

    A total of 24 cases of hepatic alveolar echinococcosis (HAE) due to Echinococcus multilocularis was assessed by US and CT. The diagnosis was confirmed in all cases by immunologic and histologic study. Both US and CT patterns of HAE showed changes of liver morphology in both contour and size. Abnormal areas of parenchyma were nodular or in fields, irregular, heterogeneous, and basically echogenic. Clustered microcalcifications were encountered within the abnormal parenchymal fields in 50% of cases, and necrotized zones occurred in 40% of cases. Dilatation of intrahepatic bile ducts was commonly seen, especially on US; hilar involvement was frequent. Follow-up by both techniques can display increases of primary lesions, occurrence of new foci, and local or regional extensions. Precise evaluations of the lesions arising from correlative use of US and CT permits adequate therapeutic management.

  13. [Implant positioned buccally of the alveolar process; a complication].

    Science.gov (United States)

    Abas, I; Meijer, G J

    2016-02-01

    Because of a blue discolouration of her mucosa a 58-year-old patient visited her new dentist. Her medical history revealed that several months before an implant in the region of dental element 22 had been installed. When palpating the alveolar region, a painless hard swelling was felt. As a malposition of the implant was suspected, it was decided to have a cone beam computed tomography-scan made. The sagittal scan revealed that apically the implant in the region of dental element 22 was not embedded in the jawbone. Following the placement of an implant, it is always necessary to verify that the implant procedure has been carried out successfully; palpating the implant bed is always required. PMID:26878714

  14. Hereditary gingivo-alveolar hyperplasia: a report of two siblings.

    Science.gov (United States)

    Prasetyono, Theddeus O H; Ekaputri, Krista

    2015-02-01

    Gingival hyperplasia is characterized by fibrotic gingival overgrowth. The lesion may bury all the crown of the teeth and lead to impairment in masticatory functions and aesthetic disfigurement. This inherited disease is considered rare. We presented two cases of gingival hyperplasia in two siblings: an 11-year-old girl and an 8-year-old boy, whose mother had also suffered from the disease. The two siblings presented with generalized gingival overgrowth involving the maxillary and mandibular arches and covering almost all of the teeth. We performed surgery to reduce the excessive gingivo-alveolar tissue and disclosed most of the teeth. The patients showed functional and aesthetic improvement. The last follow-up through a phone call, which was conducted 12 months after the surgery, revealed no recurrent hyperplasia.

  15. Sequential gas delivery provides precise control of alveolar gas exchange.

    Science.gov (United States)

    Fisher, Joseph A; Iscoe, Steve; Duffin, James

    2016-05-01

    Of the factors determining blood gases, only alveolar ventilation (V˙A) is amenable to manipulation. However, current physiology text books neither describe how breath-by-breath V˙A can be measured, nor how it can be precisely controlled in spontaneously breathing subjects. And such control must be effected independent of minute ventilation (V˙E) and the pattern of breathing. Control of V˙A requires the deliberate partition of inhaled gas between the alveoli and the anatomical deadspace. This distribution is accomplished by sequential gas delivery (SGD): each breath consists of a chosen volume of 'fresh' gas followed by previously exhaled gas. Control of V˙A through SGD is a simple, inexpensive, yet powerful tool with many applications. Here we describe how to implement SGD, how it precisely controls V˙A, and consequently how it controls arterial blood gases. PMID:26840836

  16. A case of pulmonary alveolar microlithiasis with Cor Pulmonale.

    Science.gov (United States)

    Chen, Wen; Gu, Tao

    2012-03-01

    Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the formation and deposition of microliths within the alveoli and a paucity of symptoms in contrast to the imaging findings. It has familial tendency and is thought to be an autosomal recessive disorder with the mutation in the SLC34A2 gene. We describe a case of PAM with Cor Pulmonale. Ultrasonic cardiogram showed pulmonary hypertension (82 mmHg). Chest radiography revealed diffuse, bilateral sandstorm-like micronodules with greater density in the lower lung fields. HRCT scans demonstrated diffuse ground-grass opacities, thickening and calcification of interlobular septa and confluent calcified nodules. A diagnosis of PAM was suggested and confirmed by transbronchial lung biopsy (TBLB). PMID:23256064

  17. ANALISIS SPASIAL KEJADIAN LUAR BIASA (KLB KASUS LEPTOSPIROSIS DI KABUPATEN KULONPROGO TAHUN 2011

    Directory of Open Access Journals (Sweden)

    Rahmawati Rahmawati

    2014-01-01

    Full Text Available ABSTRACTIndonesia's case totally rate of leptospirosis was ranked third in the world. There were outbreak of leptospirosis in2011 with 273 cases with 18 deaths (CFR = 6.59%. Therefore it was necessary to describe the spread ofleptospirosis. This research was descriptive study that using cross-sectional design with 249 leptospirosis casesrecorded by Kulonprogo District Health Office during January to November 2011. The coordinates of the patientswas determined by GPS. The data is displayed with digital maps Indonesian RBI (RBI scale 1: 25,000 usingArcView 3.3 software. Spatial analysis is done by scoring the following variable i.e. rainfall, land use and altitude.The results showed correlation of rainfall with leptospirosis cases is 0.179, most of cases occured in plantationand residential land use with altitude 0-100asl. Rainfall concluded weak relationship with leptospirosis. Spatialanalysis shows 55.7% of cases of leptospirosis occur in moderate vulnerability zone and 31.79% occur in lowvulnerability.Key words: spatial analysis, rainfall, land use, altitudeABSTRAKPada tahun 2011 terjadi KLB di Kulonprogo dengan jumlah kasus 273 dan jumlah kematian 18 orang (CFR =6,59%. Oleh sebab itu sangat penting untuk mengetahui gambaran penyebaran leptospirosis. Analisis inimerupakan studi deskriptif dengan menggunakan pendekatan cross sectional menggunakan subjek berjumlah249 kasus yang terdata di Dinas Kabupaten Kulonprogo selama bulan Januari-November 2011. Titik koordinatrumah penderita ditentukan dengan GPS. Data ditampilkan dengan peta digital Rupa Bumi Indonesia (RBIskala 1 : 25000 menggunakan software ArcView 3.3. Analisis spasial dilakukan dengan skoring pada variabelcurah hujan, penggunaan lahan dan ketinggian tempat. Analisis spasial besarnya curah hujan dengan kejadianleptospirosis pada masa tersebut menunjukkan angka korelasi 0,179, dengan demikian korelasi antara curahhujan dengan kasus leptospirosis sangat lemah. Kasus leptospirosis di

  18. Konspirasi Media Massa Dan Pengembalian Bahasa Pada Hakikatnya : Sebuah Penerapan Metode Analisis Tindak Tutur Komunikasi

    Directory of Open Access Journals (Sweden)

    Wahyu Wibowo

    2014-12-01

    Full Text Available Abstrak : Abad ke-21 dapat disebut sebagai Abad Bahasa, mengingat kehidupan manusia dewasa ini tidak dapat dilepaskan dari pelbagai bentuk media massa. Akan tetapi, terkait dengan pengonstruksian fakta dan realitas, apalagi jika dilumuri oleh ego-sentris subjek-subjek di balik media massa tersebut, kerap terjadi bias pemberitaan yang memicu problem etis. Artinya, terjadi konspirasi di balik pemberitaan yang berdampak pada pengerdilan fungsi media massa sebagai wadah pendidikan politik bagi rakyat dalam kehidupan berbangsa dan bernegara. Demi membongkar konspirasi tersebut dibutuhkan metode analisis teks media yang baru, yang di dalam tulisan ini disebut metode analisis tindak tutur komunikasi. Metode ini dilahirkan secara hereustik, kritis, dan kontekstual melalui prinsip-prinsip kontemporer aliran Filsafat Bahasa Sehari-hari. Dengan demikian, metode ini selain hendak menegaskan bahwa komunikasi massa harus dilakukan secara etis dan emansipatoris, sekaligus hendak mengoreksi eksistensi metode analisis teks media lainnya yang selama ini sudah dikenal, namun tidak berdaya ketika harus membongkar konspirasi di balik pemberitaan media massa.Kata kunci : problem etis, metode analisis tindak tutur komunikasi, filsafat bahasa sehari-hari, analisis teks media. Abstract : The twenty-first century may be referred toas the century of language, considering how human life is inseparable from the various forms of mass media. However, concerning the construction of facts and reality, especially whenever mass-media becomes colored by ego-centric tendencies, biases in reporting frequently occur that raise ethical problems. It follows that there has been a conspiracy behind mass-media that has impact inobstructing the function of media as a forum for political education for the people. Therefore, in order to reveal the conspiracy a new media text analysis method -- which in this paper is called speech-act analysis method of communication -- is required. The

  19. Substrate stiffness regulates extracellular matrix deposition by alveolar epithelial cells

    Directory of Open Access Journals (Sweden)

    Jessica L Eisenberg

    2011-01-01

    Full Text Available Jessica L Eisenberg1,2, Asmahan Safi3, Xiaoding Wei3, Horacio D Espinosa3, GR Scott Budinger2, Desire Takawira1, Susan B Hopkinson1, Jonathan CR Jones1,21Department of Cell and Molecular Biology, 2Division of Pulmonary Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 3Department of Mechanical Engineering, Northwestern University, Evanston, IL, USAAim: The aim of the study was to address whether a stiff substrate, a model for pulmonary fibrosis, is responsible for inducing changes in the phenotype of alveolar epithelial cells (AEC in the lung, including their deposition and organization of extracellular matrix (ECM proteins.Methods: Freshly isolated lung AEC from male Sprague Dawley rats were seeded onto polyacrylamide gel substrates of varying stiffness and analyzed for expression and organization of adhesion, cytoskeletal, differentiation, and ECM components by Western immunoblotting and confocal immunofluorescence microscopy.Results: We observed that substrate stiffness influences cell morphology and the organization of focal adhesions and the actin cytoskeleton. Surprisingly, however, we found that substrate stiffness has no influence on the differentiation of type II into type I AEC, nor does increased substrate stiffness lead to an epithelial–mesenchymal transition. In contrast, our data indicate that substrate stiffness regulates the expression of the α3 laminin subunit by AEC and the organization of both fibronectin and laminin in their ECM.Conclusions: An increase in substrate stiffness leads to enhanced laminin and fibronectin assembly into fibrils, which likely contributes to the disease phenotype in the fibrotic lung.Keywords: alveolar epithelial cells, fibrosis, extracellular matrix, substrate stiffness

  20. Alveolar ridge augmentation with titanium mesh. A retrospective clinical study.

    Science.gov (United States)

    Poli, Pier P; Beretta, Mario; Cicciù, Marco; Maiorana, Carlo

    2014-01-01

    An adequate amount of bone all around the implant surface is essential in order to obtain long-term success of implant restoration. Several techniques have been described to augment alveolar bone volume in critical clinical situations, including guided bone regeneration, based on the use of barrier membranes to prevent ingrowth of the epithelial and gingival connective tissue cells. To achieve this goal, the use of barriers made of titanium micromesh has been advocated. A total of 13 patients were selected for alveolar ridge reconstruction treatment prior to implant placement. Each patient underwent a tridimensional bone augmentation by means of a Ti-mesh filled with intraoral autogenous bone mixed with deproteinized anorganic bovine bone in a 1:1 ratio. Implants were placed after a healing period of 6 months. Panoramic x-rays were performed after each surgical procedure and during the follow-up recalls. Software was used to measure the mesial and the distal peri-implant bone loss around each implant. The mean peri-implant bone loss was 1.743 mm on the mesial side and 1.913 mm on the distal side, from the top of the implant head to the first visible bone-implant contact, at a mean follow-up of 88 months. The use of Ti-mesh allows the regeneration of sufficient bone volume for ideal implant placement. The clinical advantages related to this technique include the possibility of correcting severe vertical atrophies associated with considerable reductions in width and the lack of major complications if soft-tissue dehiscence and mesh exposures do occur. PMID:25317209

  1. Alveolar subphase pH in the lungs of anesthetized rabbits.

    OpenAIRE

    Nielson, D W; Goerke, J; Clements, J. A.

    1981-01-01

    We measured the pH of the alveolar subphase fluid by puncturing the most superficial alveoli of the exposed lungs of anesthetized rabbits with H+-selective and nonselective KCl microelectrodes. In these experiments, we bathed the lung surface with paraffin oil or buffered Ringer's solutions that had a CO2 tension of 40 Torr (1 Torr = 133.3 Pa) and found an alveolar pH of 6.92 +/- 0.01 (mean +/- sEM). When the pH of the surface buffer was below 6.7 or above 7.5, alveolar pH varied with surface...

  2. Alveolar recruitment maneuver in refractory hypoxemia and lobar atelectasis after cardiac surgery: A case report

    Directory of Open Access Journals (Sweden)

    Herbst-Rodrigues Marcus

    2012-06-01

    Full Text Available Abstract Objective This case report describes an unusual presentation of right upper lobe atelectasis associated with refractory hypoxemia to conventional alveolar recruitment maneuvers in a patient soon after coronary artery bypass grafting surgery. Method Case-report. Results The alveolar recruitment with PEEP = 40cmH2O improved the patient’s atelectasis and hypoxemia. Conclusion In the present report, the unusual alveolar recruitment maneuver with PEEP 40cmH2O showed to be safe and efficient to reverse refractory hypoxemia and uncommon atelectasis in a patient after cardiac surgery.

  3. CARCINOMA BRONQUÍOLO-ALVEOLAR: ASPECTOS NA TOMOGRAFIA COMPUTADORIZADA DE ALTA RESOLUÇÃO

    OpenAIRE

    Moreira Luiza Beatriz Melo; Marchiori Edson; Melo Alessandro Severo Alves de; Magnago Marcelo; Muniz Maria Angélica Soares; Irion Klaus

    2002-01-01

    O carcinoma bronquíolo-alveolar é um tipo de carcinoma broncogênico de crescimento insidioso, que surge nas paredes das vias aéreas distais e se dissemina utilizando o septo alveolar como um estroma, preservando a arquitetura pulmonar. Neste trabalho foram analisadas as tomografias computadorizadas de alta resolução de 17 pacientes com carcinoma bronquíolo-alveolar. Ao contrário do relatado na literatura, foram observados predomínio no sexo masculino (71%) e maior freqüência da associação das...

  4. Tracking X-ray microscopy for alveolar dynamics in live intact mice

    OpenAIRE

    Chang, Soeun; Kwon, Namseop; Weon, Byung Mook; Kim, Jinkyung; Rhee, Chin Kook; Choi, Han Sung; Kohmura, Yoshiki; Yamamoto, Masaki; Ishikawa, Tetsuya; Je, Jung Ho

    2013-01-01

    Here we report a tracking X-ray microscopy (TrXM) as a novel methodology by using upper right lung apices alveoli in live intact mice. By enabling tracking of individual alveolar movements during respiration, TrXM identifies alveolar dynamics: individual alveoli in the upper lung apices show a small size increment as 4.9 ± 0.4% (mean ± s.e.m.) during respiration while their shapes look almost invariant. TrXM analysis in alveolar dynamics would be significant for better understanding of alveol...

  5. ANALISIS KEBERADAAN BIDAN DESA DAN DUKUN BAYI DI JAWA TIMUR

    Directory of Open Access Journals (Sweden)

    Mochamad Setyo Pramono

    2013-03-01

    through the course. Suggestion: Patterns midwife partnership with shamans only one way to improve the coverage of deliveries by health personnel. The approach must be done from two sides, which is also in the community. The abilityof midwives to promotive and preventive accordance with the local culture are factors in addition to the factors of education and knowledge in society itself. Key words: midwives, tradistional birth attendants, East Java ABSTRAK Latar Belakang: Tujuan MDGs yang berupa meningkatkan kesehatan ibu, salah satu indikatornya adalah proporsi pertolongan kelahiran oleh tenaga kesehatan terlatih. Terkait dengan hal tersebut yang menjadi ujung tombak dilapangan adalah bidan desa. Kehadiran profesi bidan bukan berada di dalam lahan yang kosong, karena secara tradisi keberadaan dukun bayi telah ada terlebih dahulu. Pada kondisi geografis dan sosial masyarakat yang beragam, keberadaan mereka bisa menjadi khazanah kekayaan budaya. Menjadi menarik ketika dua kepentingan yang sejalan tetapi berbeda latar belakang ini bertemu di lapangan. Bagaimana eksistensi mereka di masyarakat terutama di perdesaan yang tradisinya masih kuat. Metode: Penelitian ini merupakan gabungan penelitian kuantitatif dan kualitatif. Penelitian ini dilakukan pada tahun 2011 di empat kabupaten di Jawa Timur yaitu Sampang, Probolinggo, Jombang dan Madiun. Pemilihan kabupaten mengacu pada karakteristik masyarakat di Jawa Timur yaitu Madura, Pandalungan, Arek dan Mataraman. Pengumpulan data dilakukan dengan cara observasi dan wawancara mendalam, informannya adalah bidan desa dan dukun bayi pada tiap wilayah puskesmas terpilih. Data dianalisis dengan teknik analisis domain, kategorial dan komponensial, sehingga membentuk matriks atau tipologi. Hasil: Terdapat dikotomi bidan senior dan bidan muda. Bidan senior kebanyakan berasal dari luar daerah. Jumlahnya terbatas sementara cakupan wilayah yang luas, tidak jarang membuat mereka memilih tinggal di pusat kecamatan. Akibatnya, pelayanan

  6. ANALISIS KEMAMPUAN MENATA ARSIP SISWA JURUSAN ADMINISTRASI PERKANTORAN

    Directory of Open Access Journals (Sweden)

    Bunga Aprilia Kartini

    2016-02-01

    Full Text Available Salah satu kemampuan yang harus dimiliki Program Administrasi Perkantoran adalah kompetensi dasar penataan dokumen. Kompetensi yang diharapkan dari kompetensi penataan dokumen adalah dapat menyimpan dan menemukan kembali dokumen/arsip sesuai dengan sistem yang diterapkan dalam perusahaan. Pembelajaran yang terjadi di SMK PGRI 2 Salatiga, siswa jurusan Administrasi Perkantoran tidak mendapatkan praktik menemukan kembali arsip/dokumen serta tidak ada laboratorium khusus kearsipan. Hal ini tentu akan mempengaruhi kemampuan lulusan dari siswa-siswanya. Kemampuan tersebut akan berujung pada kemampuan lulusan dalam memenuhi standar kerja suatu perusahaan atau organisasi. Populasi dalam penelitian ini yaitu seluruh siswa kelas XI Jurusan Administrasi Perkantoran SMK PGRI 2 Salatiga yang terdiri dari 2 kelas dengan jumlah 64 siswa. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan teknik pengumpulan data menggunakan metode wawancara, observasi dan kuesioner. Teknik analisis data yang digunakan adalah dengan angka indeks. Hasil Penelitian menunjukan bahwa rata-rata kemampuan siswa dalam menata dokumen/arsip dengan angka indeks adalah sebesar 68,85 hal tersebut menunjukkan bahwa siswa umumnya memiliki kemampuan yang sedang, walaupun secara teori pemahaman siswa sudah cukup baik namun secara praktik siswa masih memiliki kekurangan yaitu siswa kurang menguasai dalam praktik mengindeks, memberikan kode penyimpanan, pencatatan kartu pinjam arsip, membaca kode penyimpanan dan prosedur penemuan kembali arsip/dokumen. Siswa juga belum diajarkan praktik penyimpanan sistem wilayah, sistem nomor dan sistem subjek/perihal sehingga kemampuan meraka dalam sistem penyimpanan tersebut masih kurang serta siswa juga belum diajarkan praktik penemuan kembali surat/arsip. Office Administration program is one of the must have skills that are the basis of the competencies document setup. Learning happens in SMK PGRI 2 Salatiga , students in Administrative

  7. ANALISIS PENGARUH KREDIBILITAS MEREK TERHADAP SENSITIVITAS HARGA KONSUMEN

    Directory of Open Access Journals (Sweden)

    Anik - Kusmintarti

    2012-05-01

    Full Text Available ABSTRAKS   Informasi yang tidak sempurna dan tidak simetris mengakibatkan timbulnya ketidakpastian yang dihadapi konsumen tentang atribut dan/ atau manfaat apa yang didapat dari sebuah produk.  Dalam kondisi seperti ini penting bagi perusahaan untuk menyampaikan informasi terpercaya kepada konsumen, yaitu informasi yang jujur dan perusahaan harus bersedia dan mampu menyampaikan apa yang telah dijanjikan. Merek yang kredibel berpengaruh terhadap  kesan kualitas, resiko yang diterima dan biaya informasi. Kemudian kesan kualitas, resiko yang diterima dan biaya informasi akan mempengaruhi manfaat yang diharapkan.  Dan selanjutnya akan mempengaruhi sensitivitas harga konsumen. Populasi dalam penelitian ini adalah wanita dewasa yang berdomisili di kota Malang dan sampelnya adalah wanita berumur 17 sampai sengan 45 tahun yang menggunakan shampo Anti Ketombe dari satu atau lebih merek-merek yang sedang diteliti. Jumlah responden 100 orang dan metode pengambilan sampel yang digunakan adalah nonprobability sampling, dan teknik pengambilan sampel yang digunakan adalah quota sampling. Uji empiris menggunakan Metode Analisis Jalur. Hasil penelitian menunjukkan bahwa kredibilitas merek berpengaruh terhadap sensitivitas harga konsumen. Selain itu kredibilitas merek berpengaruh secara tak langsung terhadap sensitivitas harga konsumen melalui kesan kualitas dan manfaat yang diharapkan; Kredibilitas merek berpengaruh tak langsung terhadap sensitivitas harga konsumen melalui melalui biaya informasi dan manfaat yang diharapkan. Pengaruh kredibilitas merek terhadap sensitivitas harga konsumen melalui resiko yang dirasakan dan manfaat yang diharapkan tidak signifikan. Temuan ini tidak konsisten dengan temuan dari penelitian yang dilakukan Erdem dan Swait (1998. Hal ini menurut peneliti disebabkan oleh responden dari penelitian yang peneliti lakukan cenderung mudah percaya dengan informasi-informasi yang ada disekelilingnya dan kurang peduli dengan keberadaan

  8. ANALISIS DAN MODEL STRATEGI PENINGKATAN DAYA SAING PRODUK EDAMAME BEKU

    Directory of Open Access Journals (Sweden)

    Sandryas Alief Kurniasanti

    2015-03-01

    penelitian ini adalah untuk menganalisis daya saing dan merumuskan prioritas alternatif strategi peningkatan daya saing produk edamame beku di PT MT 27. Metode yang digunakan dalam penelitian ini adalah Revealed Comparative Advantage untuk mengetahui kinerja ekspor dari produk edamame beku di pasar dunia, kemudian menganalisis faktor persaingan dengan menggunakan Diamond Porter’s Theory. Alternatif strategi dihasilkan dari analisis SWOT dan ditentukan prioritasnya dengan menggunakan analytical hierarchy process dari satu narasumber ahli. Hasil penelitian menunjukkan bahwa prioritas alternatif strategi peningkatan daya saing produk edamame beku PT MT 27 secara berurutan meliputi: (1 diversifikasi pasar, (2 diversifikasi produk, (3 meningkatkan kerjasama luar negeri, (4 pengembangan divisi Research and Development, (5 mengembangkan program Corporate Social Responsibility, (6 pengelolaan keuangan secara baik dan benar, serta (7 mengembangkan areal pertanian yang berbasis rumah kaca untuk menghindari cuaca buruk karena beriklim tropis. Implikasi Manajerial dari penelitian ini adalah mengembangkan pasar yang sudah ada, dan mengembangkan jenis produk yang diproduksi untuk memenuhi selera pasar ekspor dan juga penghematan biaya produksi. Kata kunci: daya saing, edamame beku, Mitratani Dua Tujuh, strategi daya saing

  9. Analisi preclinica di nuove strategie terapeutiche basate sull'inibizione di protein-chinasi nell'osteosarcoma.

    OpenAIRE

    Vella, Serena

    2013-01-01

    Scopo: L’obiettivo del presente programma di studio è stato quello di identificare e validare nuovi possibili bersagli terapeutici per l’osteosarcoma (OS) partendo dall’analisi del chinoma umano. Risultati: L’analisi del profilo di espressione genica ottenuta su 21 campioni clinici di OS ad alto grado di malignità ha permesso di selezionare le seguenti chinasi di possibile rilevanza biologica per l’OS: AURK-A, AURK-B, CDK2, PIK3CA, PLK-1. Le chinasi selezionate sono state validate tr...

  10. HASIL ANALISIS VITAMIN A DAN β-KAROTEN BAHAN MAKANAN SUMBER VITAMIN A DAN KAROTEN DENGAN METODE HPLC

    OpenAIRE

    Yuniar Rosmalina; Dewi Permaesih

    2012-01-01

    Telah dilakukan analisis vitamin A DAN β-Karoten terhadap beberapa jenis pangan dengan menggunakan metode HPLC. Analisis dilakukan terhadap 9 jenis serealia dan umbi-umbian, 3 jenis kacang-kacangan, 40 jenis sayuran, 11 jenis daging dan hasilnya, 7 jenis telur dan hasilnya, 8 jenis ikan, 12 jenis buah-buahaan, dan 7 jenis kelompok lain-lain. Hasilnya menunjukkan sumber β-Karoten yang tinggi pada kelompok serealia dan umbi-umbian adalah umbi jalar, pada kelompok sayuran adalah daun katuk, daun...

  11. Alveolar system of Paramecium. I. Trapping polycationic dye as a result of membrane impairment.

    Science.gov (United States)

    Wyroba, E

    1981-01-01

    The function of Paramecium alveolar system underlying the cell membrane has been studied. Permeability and structure of cell membrane, alveolar membranes and alveoli following alpha-amylase, beta-amylase, phospholipase C and hyaluronidase treatment has been examined. It is demonstrated that droplets of polycationic dye, ruthenium red, have been trapped within the alveoli whereas the dye was also bound by the outer and inner alveolar membrane. This suggest the presence of anionic sites capable to bind cationic compounds within the alveoli. It may be concluded that the alveolar system in Paramecium is functioning as a barrier protecting the cell against the chemicals added from the outside when the cell membrane separating the cytoplasm from the medium is impaired.

  12. Alveolar Echinococcosis Infection in a Monkey (Ateles Geoffroyi In Mashhad, Iran

    Directory of Open Access Journals (Sweden)

    H Kazemi Mehrjerdi

    2012-02-01

    Full Text Available Alveolar echinococcosis (AE, which is caused by ingestion of eggs of the fox tapeworm Echinococcus multilocularis, is the most potentially lethal parasitic infection because of its tendency to invade and proliferate in the liver and the difficulty in treatment. This article describes a case of alveolar echinococcosis found in Ateles geoffroyi in Mashhad, Iran. The cysts were characterized as an alveolar structure, composed of numerous small vesicles in liver, abdominal cavity, retroperitoneum and lungs. A characteristic feature of these vesicles was its exogenous tumor-like proliferation. These cysts were filled with numerous protoscoleces suggesting a potential role of this monkey in cycle of transmission. Up to now, this is probably the first report of alveolar echinococcosis in A. geoffroyi in the world.

  13. Multimodality imaging in diagnosis and management of alveolar echinococcosis: an update.

    Science.gov (United States)

    Bulakçı, Mesut; Kartal, Merve Gülbiz; Yılmaz, Sabri; Yılmaz, Erdem; Yılmaz, Ravza; Şahin, Dilek; Aşık, Murat; Erol, Oğuz Bülent

    2016-01-01

    Alveolar echinococcosis is a parasitic disease limited to the northern hemisphere. The disease occurs primarily in the liver and shows a profile mimicking slow-growing malignant tumors. Echinococcus multilocularis infection is fatal if left untreated. It can cause several complications by infiltrating the vascular structures, biliary tracts, and the hilum of the liver. As it can invade the adjacent organs or can spread to distant organs, alveolar echinococcosis can easily be confused with malignancies. We provide a brief review of epidemiologic and pathophysiologic profile of alveolar echinococcosis and clinical features of the disease. This article focuses primarily on the imaging features of alveolar echinococcosis on ultrasonogra-phy, computed tomography, magnetic resonance imaging, diffusion-weighted imaging and positron emission tomography-computed tomography. We also reviewed the role of radiology in diagnosis, management, and follow-up of the disease. PMID:27082120

  14. Tracheal compression delays alveolar collapse during deep diving in marine mammals.

    Science.gov (United States)

    Bostrom, Brian L; Fahlman, Andreas; Jones, David R

    2008-05-31

    Marine mammals have very compliant alveoli and stiff upper airways; an adaptation that allows air to move from the alveoli into the upper airways, during breath-hold diving. Alveolar collapse is thought occur between 30 and 100 m and studies that have attempted to estimate gas exchange at depth have used the simplifying assumption that gas exchange ceases abruptly at the alveolar collapse depth. Here we develop a mathematical model that uses compliance values for the alveoli and upper airspaces, estimated from the literature, to predict volumes of the respiratory system at depth. Any compressibility of the upper airways decreases the volume to contain alveolar air yielding lung collapse pressures 2x that calculated assuming an incompressible upper airway. A simple relationship with alveolar volume was used to predict relative pulmonary shunt at depth. The results from our model agree with empirical data on gas absorption at depth as well as the degree of tracheal compression in forced and free diving mammals.

  15. Unsuspected pulmonary alveolar proteinosis in a patient with a slow resolving pneumonia: A case report

    OpenAIRE

    Main, Stephanie; Somani, Vikas; Molyneux, Angus; Bhattacharya, Milan; Randhawa, Rabinder; Kavidasan, Ajikumar

    2013-01-01

    Pulmonary Alveolar Proteinosis (PAP) is a rare condition with an incidence of one in two million and is classified as primary or secondary. This is the first reported case presenting as a slow resolving pneumonia.

  16. Iron homeostatis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study

    Science.gov (United States)

    ABSTRACT: BACKGROUND: Lung injury caused by both inhaled dusts and infectious agents depends on increased availability of iron and metal-catalyzed oxidative stress. Because inhaled particles, such as silica, and certain infections can cause secondary pulmonary alveolar proteinosi...

  17. A case of pulmonary alveolar proteinosis treated with whole lung lavage.

    Science.gov (United States)

    Koplin-Baucum, Stephanie; Hurst, Susan

    2005-01-01

    Pulmonary alveolar proteinosis is rarely seen and, thus, many critical care nurses may not be familiar with the disease. This article provides information about the epidemiology, pathophysiology, and a case study of a patient with this disease. PMID:15912060

  18. Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury

    OpenAIRE

    Beck-Schimmer, B; Schwendener, R.; Pasch, T; Reyes, L.; Booy, C; Schimmer, R C

    2005-01-01

    BACKGROUND: Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate-liposomes in order to study the role of these effector cells in the early endotoxin-induced lung injury. METHODS: Lipopolysaccharide was applied intratracheally and the inflammatory reaction was assessed 4 hours later. Neutrophil accumulation an...

  19. Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury

    OpenAIRE

    Reyes Livia; Pasch Thomas; Schwendener Reto; Beck-Schimmer Beatrice; Booy Christa; Schimmer Ralph C

    2005-01-01

    Abstract Background Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate-liposomes in order to study the role of these effector cells in the early endotoxin-induced lung injury. Methods Lipopolysaccharide was applied intratracheally and the inflammatory reaction was assessed 4 hours later. Neutrophil accumula...

  20. Detection of Alveolar Fibrocytes in Idiopathic Pulmonary Fibrosis and Systemic Sclerosis

    OpenAIRE

    Borie, Raphael; Quesnel, Christophe; Phin, Sophie; Debray, Marie-Pierre; Marchal-Somme, Joelle; Tiev, Kiet; Bonay, Marcel; Fabre, Aurélie; Soler, Paul; Dehoux, Monique; Crestani, Bruno

    2013-01-01

    Background Fibrocytes are circulating precursors for fibroblasts. Blood fibrocytes are increased in patients with idiopathic pulmonary fibrosis (IPF). The aim of this study was to determine whether alveolar fibrocytes are detected in broncho-alveolar lavage (BAL), to identify their prognostic value, and their potential association with culture of fibroblasts from BAL. Methods We quantified fibrocytes in BAL from 26 patients with IPF, 9 patients with Systemic Sclerosis(SSc)-interstitial lung d...

  1. Alveolar Type II cell transplantation restores pulmonary surfactant protein levels in lung fibrosis

    OpenAIRE

    Guillamat-Prats, Raquel; Gay-Jordi, Gemma; Xaubet, Antoni; Peinado, Victor; Serrano-Mollar, Anna

    2014-01-01

    Background Alveolar Type II cell transplantation has been proposed as a cell therapy for the treatment of idiopathic pulmonary fibrosis. Its long-term benefits include repair of lung fibrosis, but its success partly depends on the restoration of lung homeostasis. Our aim was to evaluate surfactant protein restoration after alveolar Type II cell transplantation in an experimental model of bleomycin-induced lung fibrosis in rats. Methods Lung fibrosis was induced by intratracheal instillation o...

  2. Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

    OpenAIRE

    Cao, Zhongwei; Lis, Raphael; Ginsberg, Michael; Chavez, Deebly; Shido, Koji; Rabbany, Sina Y.; Fong, Guo-Hua; Sakmar, Thomas P.; Rafii, Shahin; Ding, Bi-Sen

    2016-01-01

    Although the lung can undergo self-repair after injury, fibrosis in chronically injured or diseased lungs can occur at the expense of regeneration. Here we study how a hematopoietic-vascular niche regulates alveolar repair and lung fibrosis. Using intratracheal injection of bleomycin or hydrochloric acid in mice, we show that repetitive lung injury activates pulmonary capillary endothelial cells (PCECs) and perivascular macrophages, impeding alveolar repair and promoting fibrosis. Whereas the...

  3. Activation of Alveolar Macrophages via the Alternative Pathway in Herpesvirus-Induced Lung Fibrosis

    OpenAIRE

    Mora, Ana L.; Torres-González, Edilson; Rojas, Mauricio; Corredor, Claudia; Ritzenthaler, Jeffrey; Xu, Jianguo; Roman, Jesse; Brigham, Kenneth; Stecenko, Arlene

    2006-01-01

    The etiology of idiopathic pulmonary fibrosis (IPF) is unknown. Because viral pathogenesis of IPF has been suggested, we have established a murine model of progressive pulmonary fibrosis by infecting IFN-γR–deficient mice (IFN-γR−/−) with the murine γ-herpesvirus 68. Because alveolar macrophages in humans with IPF have been implicated in driving the profibrotic response, we studied their role in our model. Chronic herpesvirus infection of the lung was associated with recruitment of alveolar m...

  4. Status Periodontal dan Kehilangan Tulang Alveolar pada Restorasi Proksimal yang Overhang

    OpenAIRE

    Devy Firena Garna; Amaliya

    2012-01-01

    A healthy periodontal tissue dependent on placing a proper restoration especially proximal restoration whereas to place an overhang restoration could be a risk factor for gingivitis and alveolar bone loss. The aim of the study was to find out relation prevalence periodontal status and alveolar bone loss on proximal restorations. A descriptive cross-sectional study was conducted on patients who visited Tarogong Dental Unit Public Health Centre, Garut Regency between March and November 2010 and...

  5. The Effects of Synthetic Cannabinoids on Alveolar-Arterial Oxygen Gradient

    Directory of Open Access Journals (Sweden)

    Egemen Kucuk

    2014-12-01

    Full Text Available Aim: Synthetic cannabinoids are chemicals that produce several marijuana-like effects in humans. Aim of this study is to investigate the effects of synthetic cannabinoids on to alveolar-arterial oxygen gradient. Material and Method: A total of 112 patients, who admitted directly to emergency clinic with synthetic cannabinoid usage, were determined between February 2014 and August 2014. Blood gases of 41 patients were determined as arterial blood gases on room air, and included in to study. Patients were evaluated according to age, sex, decade, partial pressure of arterial oxygen, partial pressure of arterial carbon dioxide, pH, bicarbonate, metabolic status, age consistent expected alveolar-arterial oxygen gradient and calculated alveolar-arterial oxygen gradient. Results: Synthetic cannabinoid using was higher in males, mean age of patients was 23.32±6.14 years. Number of patients in the third decade were significantly higher than the other decades. The calculated alveolar-arterial oxygen gradient value of patients was significantly higher than age consistent expected alveolar-arterial oxygen gradient value. Respiratory acidosis, was significantly higher than the other types of the metabolic disorders. The best cutoff point for calculated alveolar-arterial oxygen gradient was 12.70, with sensitivity of 90% and specifity of 85%. Area under curve was 0.70 for calculated alveolar-arterial oxygen gradient. Discussion: The value of alveolar-arterial oxygen gradient has been increased due to synthetic cannabinoid usage. This can be used as a supportive parameter in the diagnosis of synthetic cannabinoid usage.

  6. Serum KL-6 is a predictor of outcome in pulmonary alveolar proteinosis

    OpenAIRE

    Bonella, Francesco; Ohshimo, Shinichiro; Miaotian, Cai; Griese, Matthias; Guzman y Rotaeche, Josune; Costabel, Ulrich

    2013-01-01

    Background: Pulmonary alveolar proteinosis (PAP) is a rare disorder characterised by abundant alveolar accumulation of surfactant lipoproteins. Serum levels of KL-6, high molecular weight human MUC1 mucin, are increased in the majority of patients with PAP. The prognostic significance of KL-6 in PAP is still unknown. Aim of the study was to evaluate whether serum KL-6 levels correlate with the outcome of the disease. Patients and methods: From 2006 to 2012, we prospectively studied 33 patient...

  7. Jamming dynamics of stretch-induced surfactant release by alveolar type II cells

    OpenAIRE

    Majumdar, Arnab; Arold, Stephen P.; Bartolák-Suki, Erzsébet; Parameswaran, Harikrishnan; Suki, Béla

    2011-01-01

    Secretion of pulmonary surfactant by alveolar epithelial type II cells is vital for the reduction of interfacial surface tension, thus preventing lung collapse. To study secretion dynamics, rat alveolar epithelial type II cells were cultured on elastic membranes and cyclically stretched. The amounts of phosphatidylcholine, the primary lipid component of surfactant, inside and outside the cells, were measured using radiolabeled choline. During and immediately after stretch, cells secreted less...

  8. Inferior Alveolar Nerve Injuries Following Implant Placement - Importance of Early Diagnosis and Treatment: a Systematic Review

    OpenAIRE

    Ilana Shavit; Gintaras Juodzbalys

    2014-01-01

    ABSTRACT Objectives The purpose of this article is to systematically review diagnostic procedures and risk factors associated with inferior alveolar nerve injury following implant placement, to identify the time interval between inferior alveolar nerve injury and its diagnosis after surgical dental implant placement and compare between outcomes of early and delayed diagnosis and treatment given based on case series recorded throughout a period of 10 years. Material and Methods We performed li...

  9. A novel in vivo platform for studying alveolar bone regeneration in rat

    OpenAIRE

    Kim, Joong-Hyun; Moon, Ho-Jin; Kim, Tae-Hyun; Jo, Jong-Min; Yang, Sung Hee; Naskar, Deboki; Kundu, Subhas C.; Chrzanowski, Wojciech; Kim, Hae-Won

    2013-01-01

    Alveolar bone regeneration is a significant challenge in dental implantation. Novel biomaterials and tissue-engineered constructs are under extensive development and awaiting in vivo animal tests to find clinical endpoint. Here, we establish a novel in vivo model, modifying gingivoperiosteoplasty in rat for the alveolar bone regeneration. Rat premaxillary bone defects were filled with silk scaffold or remained empty during the implantation period (up to 6 weeks), and harvested samples were an...

  10. Hypocomplementemic urticarial vasculitis complicated with diffuse alveolar hemorrhage: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Paola Gnerre

    2014-03-01

    Full Text Available Urticarial vasculitis is a small-vessel vasculitis characterized clinically by urticaria and microscopically by leukocytoclastic vasculitis. Hypocomplementemic urticarial vasculitis syndrome is a rare subtype of urticarial vasculitis with organ involvement and persistent, acquired hypocomplementemia. Pulmonary involvement, usually seen as diffuse alveolar damage, is an uncommon complication and a significant cause of morbidity and mortality. Here we present a rare case of hypocomplementemic urticarial vasculitis syndrome complicated by diffuse alveolar damage and describe the beneficial effect of cyclophosphamide-dexamethasone.

  11. Ontogenesis of the alveolar walls of the tooth germ according to orthopantomography

    OpenAIRE

    Okushko M.R.; Suetenkov D.E.; Chependyuk Т.А.

    2015-01-01

    Objective: to identify changes of the configuration and size of the walls of the alveolar stages of ontogenesis. Materials and Methods. Orthopantomograms studied 196 children aged 5 to 12 years. We used visual and morphometric methods. Results. The data on the three diameters of the dental alveoli (proximal, middle and distal) has been presented, under which subsequently the main stages of age transformation have been highlighted. Conclusion. Transformation of the alveolar walls radiologicall...

  12. Problems of diagnosis and a clinical course of pulmonary alveolar proteinosis

    International Nuclear Information System (INIS)

    The authors have defined 3 stages of development of pulmonary alveolar proteinosis proceeding from the literature data and their own data on 4 patients. Each stage was characterized in detail with due account of clinical manifestations, in results of laboratory, X-ray, functional and radionuclide investigations. Diagnosis of the disease is a problem requiring biopsy. Bronchoalveolar lavage was shown to be the most effective method of therapy of pulmonary alveolar proteinosis

  13. Selective inhibition of intra-alveolar p55 TNF receptor attenuates ventilator-induced lung injury

    OpenAIRE

    Bertok, Szabolcs; Wilson, Michael R.; Morley, Peter J.; de Wildt, Ruud; Bayliffe, Andrew; Takata, Masao

    2011-01-01

    Background Tumour necrosis factor (TNF) is upregulated in the alveolar space early in the course of ventilator-induced lung injury (VILI). Studies in genetically modified mice indicate that the two TNF receptors play opposing roles during injurious high-stretch mechanical ventilation, with p55 promoting but p75 preventing pulmonary oedema. Aim To investigate the effects of selective inhibition of intra-alveolar p55 TNF receptor on pulmonary oedema and inflammation during ventilator-induced lu...

  14. High CO2 levels impair alveolar epithelial function independently of pH.

    Directory of Open Access Journals (Sweden)

    Arturo Briva

    Full Text Available BACKGROUND: In patients with acute respiratory failure, gas exchange is impaired due to the accumulation of fluid in the lung airspaces. This life-threatening syndrome is treated with mechanical ventilation, which is adjusted to maintain gas exchange, but can be associated with the accumulation of carbon dioxide in the lung. Carbon dioxide (CO2 is a by-product of cellular energy utilization and its elimination is affected via alveolar epithelial cells. Signaling pathways sensitive to changes in CO2 levels were described in plants and neuronal mammalian cells. However, it has not been fully elucidated whether non-neuronal cells sense and respond to CO2. The Na,K-ATPase consumes approximately 40% of the cellular metabolism to maintain cell homeostasis. Our study examines the effects of increased pCO2 on the epithelial Na,K-ATPase a major contributor to alveolar fluid reabsorption which is a marker of alveolar epithelial function. PRINCIPAL FINDINGS: We found that short-term increases in pCO2 impaired alveolar fluid reabsorption in rats. Also, we provide evidence that non-excitable, alveolar epithelial cells sense and respond to high levels of CO2, independently of extracellular and intracellular pH, by inhibiting Na,K-ATPase function, via activation of PKCzeta which phosphorylates the Na,K-ATPase, causing it to endocytose from the plasma membrane into intracellular pools. CONCLUSIONS: Our data suggest that alveolar epithelial cells, through which CO2 is eliminated in mammals, are highly sensitive to hypercapnia. Elevated CO2 levels impair alveolar epithelial function, independently of pH, which is relevant in patients with lung diseases and altered alveolar gas exchange.

  15. Functional and metabolic properties of alveolar macrophages in response to the gas phase of tobacco smoke.

    OpenAIRE

    Drath, D B; Shorey, J M; Huber, G L

    1981-01-01

    The effect of whole tobacco smoke and the gas phase of tobacco smoke on the metabolism and phagocytic ability of alveolar macrophages was monitored over a 30-day exposure period. It was demonstrated that both the gas phase and whole tobacco smoke induced a weight loss in exposed rats. Alveolar macrophage oxygen consumption was markedly increased by both exposure regimens. Superoxide generation was not affected by whole tobacco smoke exposure but was increased in response to the filtered gas p...

  16. Two cases of extrapulmonary onset granulomatosis with polyangiitis which caused diffuse alveolar haemorrhage

    Directory of Open Access Journals (Sweden)

    Halide Kaya

    2014-01-01

    Full Text Available Granulomatosis with polyangiitis (GPA is a rare form of vasculitis. Multidisciplinary therapeutic approach and early diagnosis assume vital importance in management of patients with diffuse alveolar haemorrhage caused by GPA, which is a rare complication. The purpose of this study was to present the diagnostic and therapeutic challenges experienced by clinicians in management of two severe cases of GPA with insidious extrapulmonary manifestations which rapidly progressed into acute kidney injury, alveolar haemorrhage and acute respiratory failure.

  17. The Effects of Alcohol Abuse on Pulmonary Alveolar-Capillary Barrier Function in Humans

    OpenAIRE

    Burnham, Ellen L.; Halkar, Raghuveer; Burks, Marsha; Moss, Marc

    2008-01-01

    Aims: Alcohol abuse is associated with the development of the acute respiratory distress syndrome, a disorder characterized by abnormal alveolar-capillary permeability. We hypothesized that individuals with a history of alcohol abuse would have clinical evidence of abnormal alveolar-capillary permeability even in the absence of symptoms. This could contribute to their propensity for the development of this disorder. Methods: Thirty-three subjects with a history of alcohol abuse, but no other ...

  18. Alveolar recruitment maneuver and perioperative ventilatory support in obese patients undergoing abdominal surgery.

    Science.gov (United States)

    Forgiarini Júnior, Luiz Alberto; Rezende, Juliana Castilhos; Forgiarini, Soraia Genebra Ibrahim

    2013-01-01

    The development of abdominal surgery represents an alternative therapy for the morbidly obese; however, patients undergoing this surgical procedure often experience postoperative pulmonary complications. The use of alveolar recruitment maneuvers and/or perioperative ventilatory strategies is a possible alternative to reduce these complications, focusing on the reduction of postoperative pulmonary complications. In this review, the benefits of perioperative ventilatory strategies and the implementation of alveolar recruitment maneuvers in obese patients undergoing abdominal surgery are described. PMID:24553513

  19. Activated alveolar macrophages in subclinical pulmonary inflammation in collagen vascular diseases.

    OpenAIRE

    Wallaert, B; Bart, F.; Aerts, C.; Ouaissi, A.; Hatron, P Y; Tonnel, A. B.; C. Voisin

    1988-01-01

    A study was initiated to determine whether alveolar macrophages from patients with collagen vascular diseases but free of pulmonary symptoms were spontaneously activated and whether they released various mediators related to the pathogenesis of pulmonary fibrosis. Alveolar macrophages obtained by bronchoalveolar lavage from 32 patients with proved collagen vascular disease but no evidence of lung disease were compared with those from 10 patients with collagen vascular disease with interstitia...

  20. Alveolar rhabdomyosarcoma originating between the fourth and fifth metatarsal--case report and literature review.

    LENUS (Irish Health Repository)

    Bolger, J C

    2010-09-01

    We report a case of alveolar rhabdomyosarcoma arising between the fourth and fifth metatarsal. A 13-year-old boy presented to outpatients with a history of pain and swelling in the lateral aspect of his left forefoot. Plain radiographs and MRI showed a soft tissue mass displacing the fourth metatarsal. Percutaneous biopsy revealed an alveolar rhabdomyosarcoma. Staging scans showed advanced metastatic disease. The patient was treated with chemotherapy. This highly malignant lesion remains challenging to diagnose, and difficult to treat successfully.

  1. A case of diffuse alveolar hemorrhage associated with hyaluronic acid dermal fillers

    OpenAIRE

    Basora, Jose F.; Fernandez, Ricardo; Gonzalez, Modesto; Adorno, Jose

    2014-01-01

    Patient: Male, 25 Final Diagnosis: Diffuse alveolar hemorrhage Symptoms: Cough dry • short of breath Medication: — Clinical Procedure: — Specialty: — Objective: Unusual clinical course Background: Hyaluronic acid is a substance that is naturally present in the human body, especially in joints and eyes. Hyaluronic acid injectable gels have been available for the general market since 2003 as cosmetic dermal fillers and skin boosters. Diffuse alveolar hemorrhage is an acute event that threatens ...

  2. Whole Lung Lavage of Nine Children with Pulmonary Alveolar Proteinosis: Experience in a Tertiary Lung Center

    OpenAIRE

    Badiozaman Radpay; Tahereh Parsa; Shideh Dabir; Mohammadreza Boloursaz; Ahmadreza Arbab; Seyyedahmad Tabatabaei

    2013-01-01

    Background: Pulmonary alveolar proteinosis (PAP) is a rare disease in children, characterized by intra-alveolar accumulation of large amounts of surfactant proteins, which severely reduce gas exchange. Whole lung lavage (WLL) is the preferred technique for the treatment of severe PAP.Case Presentation: This report presents nine pediatric cases with advanced PAP who underwent WLL under general anesthesia during a 9 year period. One patient was treated with multiple unilateral WLL without emplo...

  3. Computed tomographic imaging of pulmonary alveolar proteinosis; Computertomographisches Bild der pulmonalen Alveolarproteinose

    Energy Technology Data Exchange (ETDEWEB)

    Pitton, M.B. [Klinik mit Poliklinik fuer Radiologie, Univ. Mainz (Germany); Schweden, F. [Klinik mit Poliklinik fuer Radiologie, Univ. Mainz (Germany); Wilhelm, K. [Medizinische Klinik 3, Abt. Pneumologie, Univ. Mainz (Germany); Wengler-Becker, U. [Inst. fuer Pathologie, Univ. Mainz (Germany); Thelen, M. [Klinik mit Poliklinik fuer Radiologie, Univ. Mainz (Germany)

    1995-01-01

    Pulmonary alveolar proteinosis is a rare disease of uncertain etiology. The computed tomographic image is characterized by geographically sharply delineated alveolar infiltrates, faint, ground-glass-like parenchymal turbidity, with well bordered interstitial structures and recesses in the subpleural space. (orig.) [Deutsch] Die pulmonale Alveolarproteinose ist eine seltene Erkrankung unklarer Aetiologie. Das computertomographische Bild ist durch geographisch scharf demarkierte alveolaere Infiltrate, flaue milchglasartige Parenchymtruebungen mit gut abgrenzbaren interstitiellen Strukturen und Aussparung des Subpleuralraumes charakterisiert. (orig.)

  4. Whole lung lavage in alveolar proteinosis: manual clapping versus mechanical chest percussion

    OpenAIRE

    Ars, Catherine; Delguste, Pierre; M’Bazoa, Marie-Paule Biettlot Catherine; Rennotte, Marie-Therese; Weynand, Birgit; Pilette, Charles; Rodenstein, Daniel O

    2009-01-01

    Alveolar proteinosis is an uncommon lung disease presenting in primary or secondary forms, characterised by surfactant derived proteinous material accumulation within the lungs. The most effective treatment remains whole lung lavage under general anaesthesia. We have recently performed whole lung lavage in a 46-year-old patient with alveolar proteinosis who presented with severe dyspnoea and hypoxia. During the left lung lavage, outwards flow was enhanced at random either by manual clapping o...

  5. Pulmonary alveolar proteinosis: diagnosis using routinely processed smears of bronchoalveolar lavage fluid.

    OpenAIRE

    Mikami, T.; Yamamoto, Y; Yokoyama, M.; Okayasu, I

    1997-01-01

    AIMS: For the diagnosis of pulmonary alveolar proteinosis from bronchoalveolar lavage specimens it is normally necessary to make an ultrastructural examination. However, this is thought to be impractical for bronchoalveolar lavage specimens that have been routinely fixed in ethanol. In the present study, bronchoalveolar lavage cytology smears on slide glasses were examined directly ultrastructurally to make a diagnosis of pulmonary alveolar proteinosis. METHODS: Bronchoalveolar lavage smears ...

  6. Long-term follow-up and treatment of congenital alveolar proteinosis

    OpenAIRE

    Griese, Matthias; Ripper, Jan; Sibbersen, Anke; Lohse, Pia; Lohse, Peter; Brasch, Frank; Schams, Andrea; Pamir, Asli; Schaub, Bianca; Muensterer, Oliver J; Schoen, Carola; Gloeckner-Pagel, Judith; Nicolai, Thomas; Reiter, Karl; Hector, Andreas

    2011-01-01

    Background: Clinical presentation, diagnosis, management and outcome of molecularly defined congenital pulmonary alveolar proteinosis (PAP) due to mutations in the GM-CSF receptor are not well known. Case presentation: A 2 1/2 years old girl was diagnosed as having alveolar proteinosis. Whole lung lavages were performed with a new catheter balloon technique, feasible in small sized airways. Because of some interstitial inflammation in the lung biopsy and to further improve the condition, empi...

  7. A case of pulmonary alveolar proteinosis treated with whole lung lavage

    OpenAIRE

    Bansal, Avdhesh; Sikri, Vikas

    2013-01-01

    Pulmonary alveolar proteinosis represents a rare syndrome characterized by the accumulation of proteinaceous phospholipid-laden material in the alveoli. This leads to impaired gas exchange and arterial hypoxemia of varying degrees. The diagnosis is confirmed by lung biopsy. Sequential whole-lung lavage (WLL) first described in 1963 is the standard of care. We report a case of a male diagnosed of having pulmonary alveolar proteinosis (PAP) on transbroncial lung biopsy (TBLB). He was treated wi...

  8. Long-term follow-up and treatment of congenital alveolar proteinosis

    OpenAIRE

    Griese, Matthias; Ripper, Jan; Sibbersen, Anke; Lohse, Pia; Lohse, Peter; Brasch, Frank; Schams, Andrea; Pamir, Asli; Schaub, Bianca; Muensterer, Oliver J; Schön, Carola; Glöckner-Pagel, Judith; Nicolai, Thomas; Reiter, Karl; Hector, Andreas

    2011-01-01

    Background Clinical presentation, diagnosis, management and outcome of molecularly defined congenital pulmonary alveolar proteinosis (PAP) due to mutations in the GM-CSF receptor are not well known. Case presentation A 2 1/2 years old girl was diagnosed as having alveolar proteinosis. Whole lung lavages were performed with a new catheter balloon technique, feasible in small sized airways. Because of some interstitial inflammation in the lung biopsy and to further improve the condition, empiri...

  9. Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis

    OpenAIRE

    Piccoli, Luca; Campo, Ilaria; Fregni, Chiara Silacci; Rodriguez, Blanca Maria Fernandez; Minola, Andrea; Sallusto, Federica; Luisetti, Maurizio; Corti, Davide; Lanzavecchia, Antonio

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. In this study, we characterize 21 GM-CSF autoantibodies from PAP patients and find that somatic mutations critically determine their specificity for the self-antigen. Individual antibodies only partially neutralize GM-CSF activity using an in vitro bioassay, depending on the experimental conditions, while, when injected in ...

  10. Long-term follow-up and treatment of congenital alveolar proteinosis

    OpenAIRE

    Muensterer Oliver J; Schaub Bianca; Pamir Asli; Schams Andrea; Brasch Frank; Lohse Peter; Lohse Pia; Sibbersen Anke; Ripper Jan; Griese Matthias; Schön Carola; Glöckner-Pagel Judith; Nicolai Thomas; Reiter Karl; Hector Andreas

    2011-01-01

    Abstract Background Clinical presentation, diagnosis, management and outcome of molecularly defined congenital pulmonary alveolar proteinosis (PAP) due to mutations in the GM-CSF receptor are not well known. Case presentation A 2 1/2 years old girl was diagnosed as having alveolar proteinosis. Whole lung lavages were performed with a new catheter balloon technique, feasible in small sized airways. Because of some interstitial inflammation in the lung biopsy and to further improve the conditio...

  11. Pulmonary Alveolar Proteinosis and tuberculosis in a diabetic patient: a rare or a seldom diagnosed association

    OpenAIRE

    Pereira-Silva J.L.; Marinho M.M.M.A.; Veloso T.V.B.; Coelho Filho J.C.

    2002-01-01

    A case of Pulmonary Alveolar Proteinosis (PAP), in association with tuberculosis, is described in a 35-year-old diabetic patient. Lung biopsy showed an intra-alveolar accumulation of PAS-positive material, and multifocal granulomas compatible with tuberculosis. The bronchoalveolar culture was positive for Mycobacterium tuberculosis. PAP results from an imbalance of the mechanisms that regulate the homeostasis of the surfactant, where specific proteins are involved, especially SP-A and SP-D, t...

  12. Whole lung lavage for pulmonary alveolar proteinosis after surgery for spontaneous pneumothorax

    OpenAIRE

    Stoica, R; MACRI, A.; Cordoş, I; Bolca, C

    2012-01-01

    Introduction. Pulmonary alveolar proteinosis (PAP) is a relatively rare lung disorder, probably under diagnosed, characterized by the accumulation of lipoproteinaceosus material in the lung alveoli. The primary (acquired or idiopathic) form occurs in more than 90% of all cases. Whole lung lavage is considered the golden standard of treatment. In this report, we describe a rare case of pulmonary alveolar proteinosis with severe and incapacitating respiratory, in which whole lung lavage followe...

  13. Alveolar proteinosis in extremis: a critical case treated with whole lung lavage without extracorporeal membrane oxygenation

    OpenAIRE

    Guo, Wen-Liang; Chen, Yu; Zhong, Nan-Shan; Su, Zhu-Quan; Zhong, Chang-Hao; Li, Shi-Yue

    2015-01-01

    Pulmonary alveolar proteinosis is a rare idiopathic lung disease characterized by the accumulation of lipoproteinaceous material within the alveoli, which impairs gas transfer and decreases the ventilation/perfusion ratio, and can lead to respiratory failure. Whole lung lavage is the most effective therapy for pulmonary alveolar proteinosis, but may not be tolerated by patients with severe respiratory failure. Extracorporeal membrane oxygenation support is advocated for such patients to ensur...

  14. Application of linear integration in the morphometric study of mild and severe pulmonary alveolar injury.

    Science.gov (United States)

    Coulombe, P A; Côté, M G

    1988-02-01

    In this study we applied linear integration morphometry to characterize the pulmonary alveolar reaction to toxic injury and to study possible relationships between the major tissue and cell compartments of alveolar tissue, normal and injured. Acute alveolar injury of mild and severe intensity was induced in Swiss-Webster mice by the ip administration of the chemicals diquat (4 mg/kg) and butylated hydroxytoluene (BHT; 400 mg/kg). Animals were sacrificed at Days 1 and 2 after diquat treatment and at Days 1, 3, and 5 after BHT treatment. Sampling and analysis of alveolar tissue were conducted at both levels of light and electron microscopy. Thickness distributions of arithmetic and reciprocal intercepts, as well as the arithmetic (tau) and harmonic (tau h) mean thicknesses, were established for the following alveolar compartments: septum, alveolo-capillary barrier (ACB), type I and total epithelia, capillary endothelium, and interstitium. A relative measure of the pulmonary diffusion capacity and the capillary load of alveolar septa were also determined. The parameters calculated from these thickness distributions, such as their slopes, percentages of thin intercepts, and tau/tau h ratios, proved very sensitive and useful in the detection and characterization of morphological alterations in the type I epithelial and capillary endothelial cells following either mild or severe alveolar injury. The epithelial, endothelial, and interstitial layers of pulmonary septa were all characterized by their own pattern of structural changes, so that it proved impossible to relate them in a simple way to the tissue reaction, which can be easily studied at the light microscopic level. Linear integration morphometry thus proved very useful as a morphometric approach to the study of pulmonary alveolar injury and repair. PMID:3335253

  15. A simple method for the differential characterization of alveoli and alveolar ducts in injured lungs

    OpenAIRE

    E.M. Negri; Omar, E.D.; Mori, S.S.; Rodrigues, N.R.D.; Barbas, C.S.V.; P.H.N. Saldiva; Dolhnikoff, M.

    2005-01-01

    Rationale and hypothesis: Previous studies evaluating the histoarchitecture of distal airspaces have been shown to be limited by the difficulty in adequately differentiating alveoli and alveolar ducts. This limitation has been specially noticed in studies addressing lung recruitment and in situations of diffuse alveolar damage (DAD), where generic nominations for distal airspaces had to be created, such as “peripheral airspaces” (PAS) and “large-volume gas-exch...

  16. Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics

    OpenAIRE

    Pavone, Lucio A; Albert, Scott; Carney, David; Gatto, Louis A; Halter, Jeffrey M; Nieman, Gary F.

    2007-01-01

    Introduction Acute respiratory distress syndrome causes a heterogeneous lung injury, and without protective mechanical ventilation a secondary ventilator-induced lung injury can occur. To ventilate noncompliant lung regions, high inflation pressures are required to 'pop open' the injured alveoli. The temporal impact, however, of these elevated pressures on normal alveolar mechanics (that is, the dynamic change in alveolar size and shape during ventilation) is unknown. In the present study we ...

  17. Fractal analysis of alveolarization in hyperoxia-induced rat models of bronchopulmonary dysplasia.

    Science.gov (United States)

    Porzionato, Andrea; Guidolin, Diego; Macchi, Veronica; Sarasin, Gloria; Grisafi, Davide; Tortorella, Cinzia; Dedja, Arben; Zaramella, Patrizia; De Caro, Raffaele

    2016-04-01

    No papers are available about potentiality of fractal analysis in quantitative assessment of alveolarization in bronchopulmonary dysplasia (BPD). Thus, we here performed a comparative analysis between fractal [fractal dimension (D) and lacunarity] and stereological [mean linear intercept (Lm), total volume of alveolar air spaces, total number of alveoli, mean alveolar volume, total volume and surface area of alveolar septa, and mean alveolar septal thickness] parameters in experimental hyperoxia-induced models of BPD. At birth, rats were distributed between the following groups: 1) rats raised in ambient air for 2 wk; 2) rats exposed to 60% oxygen for 2 wk; 3) rats raised in normoxia for 6 wk; and 4) rats exposed to 60% hyperoxia for 2 wk and to room air for further 4 wk. Normoxic 6-wk rats showed increased D and decreased lacunarity with respect to normoxic 2-wk rats, together with changes in all stereological parameters except for mean alveolar volume. Hyperoxia-exposed 2-wk rats showed significant changes only in total number of alveoli, mean alveolar volume, and lacunarity with respect to equal-in-age normoxic rats. In the comparison between 6-wk rats, the hyperoxia-exposed group showed decreased D and increased lacunarity, together with changes in all stereological parameters except for septal thickness. Analysis of receiver operating characteristic curves showed a comparable discriminatory power of D, lacunarity, and total number of alveoli; Lm and mean alveolar volume were less discriminative. D and lacunarity did not show significant changes when different segmentation thresholds were applied, suggesting that the fractal approach may be fit to automatic image analysis. PMID:26851258

  18. Spontaneous Pulmonary Alveolar Proteinosis in Captive "Moustached Tamarins" (Saguinus mystax) (Primates: Callitrichidae)

    OpenAIRE

    Michaud, Carmen R.; Ragland, Dan R.; Shea, Katherine I.; Zerfas, Patricia M; Kastenmayer, Robin J; St. Claire, Marisa C.; Elkins, William R; Gozalo, Alfonso S

    2011-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare human disease characterized by accumulation of surfactant in alveoli without generating an inflammatory response. Lung lesions resembling PAP were observed in seven adult tamarins (five males and two females). Gross lesions were characterized by areas of discoloration, slight bulging over the lung parenchyma, and occasional consolidation. Histological examination of tamarin lung samples revealed intra-alveolar accumulation of an amorphous, amphop...

  19. Chloride-Dependent Secretion of Alveolar Wall Liquid Determined by Optical-Sectioning Microscopy

    OpenAIRE

    Lindert, Jens; Perlman, Carrie E.; Parthasarathi, Kaushik; Bhattacharya, Jahar

    2007-01-01

    The liquid layer lining the pulmonary alveolar wall critically determines the lung's immune defense against inhaled pathogens, because it provides a liquid milieu in the air-filled alveolus for dispersal of immune cells and defensive surfactant proteins. However, mechanisms underlying formation of the liquid are unknown. We achieved visualization of the alveolar wall liquid (AWL) in situ in mouse lungs by means of optical-sectioning microscopy. Continuous liquid secretion was present in alveo...

  20. Type I Alveolar Epithelial Cells Mount Innate Immune Responses during Pneumococcal Pneumonia

    OpenAIRE

    Yamamoto, Kazuko; Ferrari, Joseph D.; Cao, Yuxia; Ramirez, Maria I.; Jones, Matthew R.; Quinton, Lee J.; Mizgerd, Joseph P.

    2012-01-01

    Pneumonia results from bacteria in the alveoli. The alveolar epithelium consists of type II cells, which secrete surfactant and associated proteins, and type I cells, which constitute 95% of the surface area and met anatomic and structural needs. Other than constitutively expressed surfactant proteins, it is unknown whether alveolar epithelial cells have distinct roles in innate immunity. Since innate immunity gene induction depends on NF-κB RelA (also known as p65) during pneumonia, we gener...

  1. Sandstorm Appearance of Pulmonary Alveolar Microlithiasis Incidentally Detected in a Young, Asymptomatic Male

    OpenAIRE

    Ch'ng, Li Shyan; Bux, Shaik Ismail; Liam, Chong Kin; Rahman, Nazarina Abdul; Ho, Choon Yan

    2013-01-01

    Pulmonary alveolar microlithiasis (PAM) is a rare chronic disease with paucity of symptoms in contrast to the imaging findings. We present a case of a 24-year-old Malay man having an incidental abnormal pre-employment chest radiograph of dense micronodular opacities giving the classical "sandstorm" appearance. High-resolution computed tomography of the lungs showed microcalcifications with subpleural cystic changes. Open lung biopsy showed calcospherites within the alveolar spaces. The radiol...

  2. Sandstorm appearance of pulmonary alveolar microlithiasis incidentally detected in a young, asymptomatic male.

    Science.gov (United States)

    Ch'ng, Li Shyan; Bux, Shaik Ismail; Liam, Chong Kin; Rahman, Nazarina Abdul; Ho, Choon Yan

    2013-01-01

    Pulmonary alveolar microlithiasis (PAM) is a rare chronic disease with paucity of symptoms in contrast to the imaging findings. We present a case of a 24-year-old Malay man having an incidental abnormal pre-employment chest radiograph of dense micronodular opacities giving the classical "sandstorm" appearance. High-resolution computed tomography of the lungs showed microcalcifications with subpleural cystic changes. Open lung biopsy showed calcospherites within the alveolar spaces. The radiological and histopathological findings were characteristic of PAM. PMID:24043987

  3. Alveolar liquid pressure measured by micropuncture in isolated lungs of mature and immature fetal rabbits.

    OpenAIRE

    Raj, J U

    1987-01-01

    Increased alveolar surface tension due to surfactant deficiency is thought to result in a negative pressure surrounding pulmonary capillaries and to promote fluid filtration. To test this hypothesis, alveolar liquid pressure (Pliquid) was measured by micropuncture in isolated lungs of mature and immature fetal rabbits (with and without surfactant replacement) at different air inflation pressures (Pairway). Lung maturity was assessed by air pressure-volume (P-V) curves. Pliquid was correlated ...

  4. Alveolar process fractures in the permanent dentition. Part 2. The risk of healing complications in teeth involved in an alveolar process fracture

    DEFF Research Database (Denmark)

    Lauridsen, Eva; Gerds, Thomas; Andreasen, Jens Ove

    2016-01-01

    AIM: To analyze the risk of pulp canal obliteration (PCO), pulp necrosis (PN), repair-related resorption (RRR), infection-related resorption (IRR), ankylosis-related resorption (ARR), marginal bone loss (MBL), and tooth loss (TL) for teeth involved in an alveolar process fracture and to identify.......3-3.5), P = 0.003), and age >30 years (HR: 2.3 (95% CI: 1.1-4.6), P = 0.02). The type of splint (rigid or flexible), the duration of splinting (more or less than 4 weeks), and the administration of antibiotics did not affect the risk of PN. CONCLUSION: Teeth involved in alveolar process fractures appear...

  5. Effect of breathing pattern on gas mixing in a model with asymmetrical alveolar ducts.

    Science.gov (United States)

    Bowes, C L; Richardson, J D; Cumming, G; Horsfield, K

    1985-01-01

    A model of the pulmonary airways was used to study three single-breath indices of gas mixing, dead space (VD), slope of the alveolar plateau, and alveolar mixing inefficiency (AMI). In the model, discrete elements of airway volume were represented by nodes. Using a finite difference technique the differential equation for simultaneous convection and diffusion was solved for the nodal network. Conducting airways and respiratory bronchioles were modeled symmetrically, but alveolar ducts asymmetrically, permitting interaction between convection and diffusion. VD, alveolar slope, and AMI increased with increasing flow. Similar trends were seen with inspired volume, although slope decreased at high inspired volumes with constant flow. VD was affected most by inspiratory flow and AMI and alveolar slope by expiratory time. VD fell approximately exponentially with time of breath holding. Eight different breathing patterns were compared. They had a small effect on alveolar slope and AMI and a greater effect on VD. The model shows how series and parallel inhomogeneity occur together and interact in asymmetrical systems: the old argument as to which is the more important should be abandoned. PMID:3968008

  6. Association of alveolar recruitment maneuvers and prone position in acute respiratory disease syndrome patients.

    Science.gov (United States)

    Costa, Daniela Caetano; Rocha, Eduardo; Ribeiro, Tatiane Flores

    2009-06-01

    The acute respiratory distress syndrome is the clinical presentation of acute lung injury characterized by diffuse alveolar damage and development of non-cardiogenic pulmonary edema due to increased pulmonary alveolar-capillary membrane permeability. Alveolar recruitment maneuvers and prone position can be used in the treatment of acute respiratory distress syndrome. The objective of this review of literature was to identify possible benefits, indications, complications and care of the associated recruitment maneuvers and prone position for treatment of the acute respiratory distress syndrome. This national and international scientific literature review was developed according to the established criteria for searching the databases MedLine, LILACS, SciElo, PubMed, Cochrane, from 1994 to 2008 in Portuguese and English, with the key words: acute respiratory distress syndrome, alveolar recruitment maneuver and prone position. Despite advances in the understanding of acute respiratory distress syndrome pathophysiology, mortality is still expressive. Alveolar recruitment maneuvers and prone position significantly contribute to treatment of acute respiratory distress syndrome patient aiming to improve oxygenation and minimizing complications of refractory hypoxemia and reduction of pulmonary compliance. However,as there are few studies in literature associating alveolar recruitment maneuvers and prone position for treatment of acute respiratory distress syndrome, additional research and evidences of clinical application are required. PMID:25303351

  7. Silicoproteinosis and primary pulmonary alveolar proteinosis: high-resolution computed tomography criteria for differential diagnosis

    International Nuclear Information System (INIS)

    Pulmonary alveolar proteinosis is a rare disease of unknown etiology, in which the main histologic finding is the presence of alveolar filling with proteinaceous material, causing restrictive lung function hypoxaemia and several radiological abnormalities. In this manuscript we reviewed the (HRCT) findings in 13 patients with pulmonary alveolar proteinosis. The study included six patients with primary disease and seven with alveolar proteinosis secondary to silicosis in sandblasters. The aim of this work was to establish HRCT distinguishing features between these conditions, since the histological findings can be identical. The most common HRCT feature of primary alveolar proteinosis was patchy ground-glass attenuation associated with smooth interlobular septal thickening, resulting in a crazy paving pattern. There was no preferential regional lung distribution of this condition, HRCT manifestations of silicoproteinosis included areas of consolidation and foci of increased attenuation consistent with calcification, hilar lymph nodes enlargement and node calcification. We concluded that in the majority of patients the presence of foci of high attenuation in the parenchyma and lymph nodes allows a prompt distinction between silicoproteinosis and primary alveolar proteinosis. (author)

  8. Rehabilitation of masticatory function improves the alveolar bone architecture of the mandible in adult rats.

    Science.gov (United States)

    Mavropoulos, Anestis; Odman, Anna; Ammann, Patrick; Kiliaridis, Stavros

    2010-09-01

    Masticatory functional changes have been shown to influence the quantity and quality of the alveolar bone during growth. This study was designed to investigate the effect of masticatory function rehabilitation on the morphology and the trabecular architecture of the mandibular alveolar bone after cessation of growth. Forty-four Sprague-Dawley male rats received soft diet in order to develop masticatory muscle hypofunction. After 21 weeks, after cessation of growth, the animals were divided into two groups: the first group continued receiving soft diet for six more weeks (hypofunction group), while the second group changed to ordinary (hard) diet with the aim to restore a normal masticatory function (rehabilitation group). A third group of 16 male rats (normal group) received ordinary (hard) diet during the whole experimental period and served as control. Micro-tomographic histomorphometry was used to evaluate the architecture of the mandibular alveolar bone (e.g. bone volume fraction, trabecular thickness, trabecular separation, etc.) at the end of the experiment (27 weeks). The height and width of the alveolar process were measured as well. The alveolar process trabecular bone volume fraction (BV/TV) was lower for the animals of the hypofunctional group as compared to those of the normal (pTV was lower in comparison to the normal group (pled to a significant improvement of alveolar bone architecture in adult rats, although the negative effects of hypofunction were not totally reversed during the period under study. PMID:20601301

  9. Analisis Film Horor Indonesia Produksi Tahun 2014 (Studi Kasus: Mall Klender dan Kamar 207

    Directory of Open Access Journals (Sweden)

    Dedi Sukatno Sembiring Meliala

    2016-02-01

    Full Text Available Abstrak Film horor erat kaitannya dengan tokoh antagonis yang menimbulkan ketakutan pada penonton dalam bentuk makhluk supranatural seperti hantu, roh jahat dan sebagainya. Karakteristik film dengan genre horor membuat penonton terbawa suasana dengan alur ceritanya yang menakutkan. Namun, beberapa dari film horor Indonesia menyajikan adegan-adegan yang kurang sopan bahkan tergolong asusila atau porno. Untuk itu, penelitian ini ingin melihat apakah terdapat konten pornografi pada film Mall Klender dan Kamar 207 yang merupakan film horor Indonesia terlaris di tahun 2014. Analisis dilakukan dengan melihat pandangan dan penilaian 30 responden dengan karakteristik yaitu penonton film horor Indonesia yang berusia 20-40 tahun. Berdasarkan hasil analisis, tidak didapatkan konten pornografi pada film Mall Klender dan Kamar 207. Adegan-adegan yang terindikasi sebagai konten pornografi ternyata masih dapat diterima oleh penonton sebagai adegan yang berada dalam batas kewajaran dan mendukung pembawaan suasana dan kesan dalam cerita yang disampaikan. Kata Kunci: film horror Indonesia, analisis konten, pornografi Abstract The horror film is closely related to the antagonist that causes fear for audience in the form of supernatural creatures such as ghosts, demons and so on. Characteristic of the horor film is to make the audience carried away with the scary plot. However, some of the existing Indonesian horror film presents scenes that classified as obscene or pornographic. Therefore, this study wanted to see if there are any pornographic content on the film Klender Mall and Room 207 is the best-selling Indonesian horror movie in 2014. The analysis was done by looking at the view and assessment of 30 respondents which are Indonesian horror movie goers aged 20-40 years. Based on the analysis, there is no founding of pornographic content on the film Klender Mall and Room 207. The scenes that indicated as pornographic content was still acceptable by the audience

  10. Alveolar osseous defect in rat for cell therapy: preliminary report Defeito ósseo alveolar em ratos para terapia celular: estudo preliminar

    Directory of Open Access Journals (Sweden)

    Cassio Eduardo Raposo-Amaral

    2010-08-01

    Full Text Available PURPOSE: To study were to reproduce an alveolar bone defect model in Wistar rats to be used for testing the efficacy of stem cell therapies. Additionally, we also aimed to determine the osteogenesis process of this osseous defect in the 1 month period post-surgery. METHODS: The animals were randomly divided into two groups of 7 animals each. A gingivobuccal incision was made, and a bone defect of 28 mm² of area was performed in the alveolar region. Animals were killed at 2 weeks after surgery (n=7 and 4 weeks after surgery (n=7. RESULTS: The average area of the alveolar defect at time point of 2 weeks was 22.27 ± 1.31 mm² and the average area of alveolar defect at time point of 4 weeks was 9.03 ± 1.17 mm². The average amount of bone formation at time point of 2 weeks was 5.73 ± 1.31 mm² and the average amount of bone formation at time point of 4 weeks was 19 ± 1.17 mm². Statistically significant differences between the amount of bone formation at 2 weeks and 4 weeks after surgery were seen (p=0.003. CONCLUSION: The highest rate of ossification occurred mostly from 2 to 4 weeks after surgery. This observation suggests that 4 weeks after the bone defect creation should be a satisfactory timing to assess the potential of bone inductive stem cells to accelerate bone regeneration in Wistar rats.OBJETIVO: Reproduzir um novo modelo de defeito ósseo alveolar em ratos Wistar que será utilizado para terapia genética e estudos com células tronco. Adicionalmente, outro objetivo do presente estudo foi determinar o pico de regeneração óssea do defeito criado na região alveolar do modelo experimental. MÉTODOS: Os animais foram aleatoriamente divididos em dois grupos de sete animais. Através de uma incisão gengivobucal foi criado um defeito ósseo medindo 28 mm² de área na região alveolar dos ratos. Os ratos foram sacrificados após duas semanas (n=7 e quatro semanas (n=7 da cirurgia. RESULTADOS: A área média do defeito alveolar ap

  11. Pulmonary alveolar proteinosis: Quantitative CT and pulmonary functional correlations

    Energy Technology Data Exchange (ETDEWEB)

    Guan, Yubao, E-mail: yubaoguan@163.com [Department of Radiology, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120 (China); State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); Zeng, Qingsi [Department of Radiology, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120 (China); Yang, Haihong; Zheng, Jinping; Li, Shiyue; Gao, Yi [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); Deng, Yu [Department of Radiology, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120 (China); Mei, Jiang [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); He, Jianxing, E-mail: jianxing63@163.com [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China); Zhong, Nanshan, E-mail: nanshan@vip.163.com [State Key Laboratory of Respiratory Disease, Guangzhou 510120 (China)

    2012-09-15

    Objective: We assessed the relationship between quantitative computer tomography (qCT) and the pulmonary function test (PFT) or blood gas analysis in pulmonary alveolar proteinosis (PAP) patients, as well as the utility of these analyses to monitor responses to whole lung lavage (WLL) therapy. Methods: Thirty-eight PAP patients simultaneously received a CT scan and PFT. Fifteen of these patients, undergoing sequential WLL for a total of 20 lavages, also underwent chest CT scans and blood gas analysis before and after WLL, and 14 of 15 patients underwent simultaneous PFT analysis. Differences between the qCT and PFT results were analyzed by canonical correlation. Results: PAP patients with low predicted values for FVC, FEV1, D{sub LCO} and D{sub LCO}/VA indicated small airspace volume and mean lung inflation, low airspace volume/total lung volume ratio and high mean lung density. Correlation and regression analysis revealed a strong correlation between D{sub LCO} and PaO{sub 2} values with CT results. The qCT results indicated that WLL significantly decreased lung weights and mean lung densities, and improved the total airspace volume/total lung volume ratios and mean lung inflations. Conclusion: Quantitative CT may be a sensitive tool for measuring the response of PAP patients to medical interventions such as WLL.

  12. Human alveolar epithelial type II cells in primary culture.

    Science.gov (United States)

    Mao, Pu; Wu, Songling; Li, Jianchun; Fu, Wei; He, Weiqun; Liu, Xiaoqing; Slutsky, Arthur S; Zhang, Haibo; Li, Yimin

    2015-02-01

    Alveolar epithelial type II (AEII) cells are a key structure and defender in the lung but also are the targets in many lung diseases, including acute respiratory distress syndrome, ventilator-induced lung injury, and pulmonary fibrosis. We sought to establish an optimized method for high yielding and long maintenance of characteristics of primary human AEII cells to facilitate the investigation of the mechanisms of lung diseases at the cellular and molecular levels. Adult human peripheral normal lung tissues of oncologic patients undergoing lung resection were collected. The AEII cells were isolated and identified by the expression of pro-surfactant protein (SP)C, epithelial sodium channel (αENaC) and cytokeratin (CK)-8, the lamellar bodies specific for AEII cells, and confirmed by the histology using electron microscopy. The phenotype of AEII cells was characterized by the expression of surfactant proteins (SP-A, SP-B, SP-C, SP-D), CK-8, KL-6, αENaC, and aquaporin (AQP)-3, which was maintained over 20 days. The biological activity of the primary human AEII cells producing SP-C, cytokines, and intercellular adhesion molecule-1 was vigorous in response to stimulation with tumor necrosis factor-α. We have modified previous methods and optimized a method for isolation of high purity and long maintenance of the human AEII cell phenotype in primary culture. This method provides an important tool for studies aiming at elucidating the molecular mechanisms of lung diseases exclusively in AEII cells. PMID:25677546

  13. Gaining Surgical Access for Repositioning the Inferior Alveolar Neurovascular Bundle

    Directory of Open Access Journals (Sweden)

    Saif Yousif Abdullah Al-Siweedi

    2014-01-01

    Full Text Available This study is aimed at determining anatomical landmarks that can be used to gain access to the inferior alveolar neurovascular (IAN bundle. Scanned CBCT (i-CAT machine data of sixty patients and reconstructions performed using the SimPlant dental implant software were reviewed. Outcome variables were the linear distances of the mandibular canal to the inferior border and the buccal cortex of the mandible, measured immediately at the mental foramen (D1 and at 10, 20, 30, and 40 mm (D2–D5 distal to it. Predictor variables were age, ethnicity, and gender of subjects. Apicobasal assessment of the canal reveals that it is curving downward towards the inferior mandibular border until 20 mm (D3 distal to the mental foramen where it then curves upwards, making an elliptic-arc curve. The mandibular canal also forms a buccolingually oriented elliptic arc in relation to the buccal cortex. Variations due to age, ethnicity, and gender were evident and this study provides an accurate anatomic zone for gaining surgical access to the IAN bundle. The findings indicate that the buccal cortex-IAN distance was greatest at D3. Therefore, sites between D2 and D5 can be used as favorable landmarks to access the IAN bundle with the least complications to the patient.

  14. Surgical treatment of painful lesions of the inferior alveolar nerve.

    Science.gov (United States)

    Biglioli, Federico; Allevi, Fabiana; Lozza, Alessandro

    2015-10-01

    Nerve-related complications are being reported with increasing frequency following oral and dental surgery, and typically involve the inferior alveolar nerve (IAN). We assess herein the etiology of neuropathic pain related to IAN injuries, and describe the various surgical treatment techniques available. Between 2007 and 2013, 19 patients were referred to the Maxillofacial Surgery Department of San Paolo Hospital (Milan, Italy) with pain in the area supplied by the IAN, which developed following endodontic treatment, oral surgery and maxillofacial surgery. All patients underwent IAN surgery by several different microsurgical procedures. Most of the patients affected by pain before surgery experienced complete or partial amelioration of symptoms. All patients receiving sural nerve grafts were pain-free 12 months after surgery. In five patients the operation was unsuccessful. In 78.94% of cases, a significant increase in nerve function was observed. Pain following IAN surgical damage may be addressed by microsurgery; nerve substitution with a sural nerve interpositional graft appears to represent the most efficacious procedure. Scar releasing, nerve decompression and nerve substitution using vein grafts are less effective. Removal of endodontic material extravasated into the mandibular canal is mandatory and effective in patients experiencing severe pain. Surgery should be performed within 12 months postoperatively, ideally during the first few weeks after symptoms onset. PMID:26315275

  15. Effect of Preoperative Pain on Inferior Alveolar Nerve Block.

    Science.gov (United States)

    Aggarwal, Vivek; Singla, Mamta; Subbiya, Arunajatesan; Vivekanandhan, Paramasivam; Sharma, Vikram; Sharma, Ritu; Prakash, Venkatachalam; Geethapriya, Nagarajan

    2015-01-01

    The present study tested the hypothesis that the amount and severity of preoperative pain will affect the anesthetic efficacy of inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis. One-hundred seventy-seven adult volunteer subjects, actively experiencing pain in a mandibular molar, participated in this prospective double-blind study carried out at 2 different centers. The patients were classified into 3 groups on the basis of severity of preoperative pain: mild, 1-54 mm on the Heft-Parker visual analog scale (HP VAS); moderate, 55-114 mm; and severe, greater than 114 mm. After IANB with 1.8 mL of 2% lidocaine, endodontic access preparation was initiated. Pain during treatment was recorded using the HP VAS. The primary outcome measure was the ability to undertake pulp access and canal instrumentation with no or mild pain. The success rates were statistically analyzed by multiple logistic regression test. There was a significant difference between the mild and severe preoperative pain group (P = .03). There was a positive correlation between the values of preoperative and intraoperative pain (r = .2 and .4 at 2 centers). The amount of preoperative pain can affect the anesthetic success rates of IANB in patients with symptomatic irreversible pulpitis. PMID:26650491

  16. The dystrophic hamster: an animal model of alveolar hypoventilation.

    Science.gov (United States)

    Schlenker, E H; Burbach, J A

    1991-11-01

    The BIO 14.6 dystrophic hamster (DH) is a genetically determined animal model of alveolar hypoventilation (AH) that exhibits a ventilatory control pattern of compensation and then decompensation similar to that in progressive forms of muscular dystrophy and nonprogressive congenital myopathies in humans. Possible causes of AH in the DH include respiratory muscle weakness, ventilation-to-perfusion inequalities, and an inadequate drive to breathe. Histochemical and contractile abnormalities of the diaphragm, reduced lung surface area available for gas exchange, abnormal pulmonary microvascular reactivity to hypoxia, altered levels of neurochemicals, and abnormal cellular regulation of calcium are among the specific factors that may contribute to the development of AH. The potential role of hypothyroidism in the development of AH is reviewed because many hypothyroid patients exhibit AH and other ventilatory dysfunctions, hypothyroidism is present in human patients and animals with muscular dystrophy, and thyroid status is known to influence lung architecture, myocyte function, and neural activity. Additional studies linking neurohormonal signals, transcellular signal processing, and control of ventilation in the DH may help us understand the etiology of AH in human disease. PMID:1684789

  17. The localization of catalase in the pulmonary alveolar macrophage.

    Science.gov (United States)

    Davies, P; Drath, D B; Engel, E E; Huber, G L

    1979-02-01

    A combined biochemical and cytochemical study of catalase was performed on alveolar macrophages lavaged from the lungs of adult male rats. Biochemically, catalase activity was present in both a high-speed granule fraction and in the supernatant. The granule-associated activity exhibited latency. Two methods of cell breakage, sonication and homogenization, yielded similar levels and distributions of catalase activity. Catalase activity in whole cells was identified cytochemically by the alkaline diaminobenzidine method and was localized within membrane-lined cytoplasmic granules similar in size to microperoxisomes and associated with cisternae of smooth endoplasmic reticulum. Localization of the reaction product was inhibited by 0.04 M aminotriazole, by cyanide, and by boiling prior to incubation. The cytochemical reaction continued in the absence of exogenous peroxide, but could be prevented by addition of catalase or pyruvate to the peroxide-free medium. Enzyme activity was also localized within a portion of the membrane-bound granules present in the cell fractions used for the biochemical assays. PMID:431040

  18. Substrate stiffness regulates extracellular matrix deposition by alveolar epithelial cells

    Science.gov (United States)

    Eisenberg, Jessica L; Safi, Asmahan; Wei, Xiaoding; Espinosa, Horacio D; Budinger, GR Scott; Takawira, Desire; Hopkinson, Susan B; Jones, Jonathan CR

    2012-01-01

    Aim The aim of the study was to address whether a stiff substrate, a model for pulmonary fibrosis, is responsible for inducing changes in the phenotype of alveolar epithelial cells (AEC) in the lung, including their deposition and organization of extracellular matrix (ECM) proteins. Methods Freshly isolated lung AEC from male Sprague Dawley rats were seeded onto polyacrylamide gel substrates of varying stiffness and analyzed for expression and organization of adhesion, cytoskeletal, differentiation, and ECM components by Western immunoblotting and confocal immunofluorescence microscopy. Results We observed that substrate stiffness influences cell morphology and the organization of focal adhesions and the actin cytoskeleton. Surprisingly, however, we found that substrate stiffness has no influence on the differentiation of type II into type I AEC, nor does increased substrate stiffness lead to an epithelial–mesenchymal transition. In contrast, our data indicate that substrate stiffness regulates the expression of the α3 laminin subunit by AEC and the organization of both fibronectin and laminin in their ECM. Conclusions An increase in substrate stiffness leads to enhanced laminin and fibronectin assembly into fibrils, which likely contributes to the disease phenotype in the fibrotic lung. PMID:23204878

  19. HES6 enhances the motility of alveolar rhabdomyosarcoma cells

    International Nuclear Information System (INIS)

    Absract: HES6, a member of the hairy-enhancer-of-split family of transcription factors, plays multiple roles in myogenesis. It is a direct target of the myogenic transcription factor MyoD and has been shown to regulate the formation of the myotome in development, myoblast cell cycle exit and the organization of the actin cytoskeleton during terminal differentiation. Here we investigate the expression and function of HES6 in rhabdomyosarcoma, a soft tissue tumor which expresses myogenic genes but fails to differentiate into muscle. We show that HES6 is expressed at high levels in the subset of alveolar rhabdomyosarcomas expressing PAX/FOXO1 fusion genes (ARMSp). Knockdown of HES6 mRNA in the ARMSp cell line RH30 reduces proliferation and cell motility. This phenotype is rescued by expression of mouse Hes6 which is insensitive to HES6 siRNA. Furthermore, expression microarray analysis indicates that the HES6 knockdown is associated with a decrease in the levels of Transgelin, (TAGLN), a regulator of the actin cytoskeleton. Knockdown of TAGLN decreases cell motility, whilst TAGLN overexpression rescues the motility defect resulting from HES6 knockdown. These findings indicate HES6 contributes to the pathogenesis of ARMSp by enhancing both proliferation and cell motility.

  20. Alveolar distraction osteogenesis – Crestal widening by distraction osteogenesis

    Directory of Open Access Journals (Sweden)

    Zvi Laster

    2010-04-01

    Full Text Available Following tooth extraction, resorption of the residual ridges occurs in both the vertical and the horizontal directions. Most of this resorption occurs within the first 6 months after tooth extraction. To correc tthis vertical/ horizontal/ dual situation, several surgical approaches have been proposed: autogenous bone grafts, guided bone regeneration, and alveolar distraction osteogenesis (ADO. In recent years, ADO has gained an ongoing popularity ,especially in view of its numerous advantages, mostimportant among them being the shortening of treatment periods and earlier dental implant placement. In cases in which there is sufficient vertical height but not enough bucco-ligual width to accommodate an implant, crestal width has to be built. Crestal widening by distraction osteogenesis is the preferred technique in suchcases. In this study a new type of crest widener, the"Laster" Crest Widening Distractor, is presented, reporting two cases where crest widening by distraction was chosen as the preferred treatment plan. Finally the main advantages and disadvantages of the new crest widening distractor are discussed, helping thus the clinician to make up his mind about this new promising device and surgical technique.

  1. [Atelectasis in general anesthesia and alveolar recruitment strategies].

    Science.gov (United States)

    Martínez, G; Cruz, P

    2008-10-01

    Atelectasis occurs in most patients during general anesthesia and is the main cause of hypoxemia. The objective of this review is to examine the causes and diagnosis of atelectasis and the different strategies for reducing or preventing this complication and improving oxygenation. Pulmonary atelectasis is mainly caused by 3 factors: compression, gas absorption, and lack of surfactant. Compression and gas absorption are, however, the 2 most commonly implicated factors. Lung collapse is accentuated if pure oxygen is inhaled during induction or if the patient is morbidly obese. Laparoscopic, thoracic, and upper abdominal interventions also carry risk of lung collapse. Various techniques may be used to prevent atelectasis or to reopen collapsed lung tissue. These include using positive end-expiratory pressure or a high tidal volume-thus providing a higher airway pressure (vital capacity maneuver)-or both in combination. Alveolar recruitment strategies have been tried in bariatric surgery, single-lung ventilation, laparoscopy, and adult respiratory distress syndrome. Their application has reduced or prevented atelectasis, thereby reducing postoperative pulmonary complications. PMID:18982787

  2. Evidence for particle transport between alveolar macrophages in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Benson, J.M.; Nikula, K.J.; Guilmette, R.A.

    1995-12-01

    Recent studies at this Institute have focused on determining the role of alveolar macrophages (AMs) in the transport of particles within and form the lung. For those studies, AMs previously labeled using the nuclear stain Hoechst 33342 and polychromatic Fluoresbrite microspheres (1 {mu}m diameter, Polysciences, Inc., Warrington, PA) were instilled into lungs of recipient F344 rats. The fate of the donor particles and the doubly labeled AMs within recipient lungs was followed for 32 d. Within 2-4 d after instillation, the polychromatic microspheres were found in both donor and resident AMs, suggesting that particle transfer occurred between the donor and resident AMs. However, this may also have been an artifact resulting from phagocytosis of the microspheres form dead donor cells or from the fading or degradation of Hoechst 33342 within the donor cells leading to their misidentification as resident AMs. The results support the earlier findings that microspheres in donor AMs can be transferred to resident AMs within 2 d after instillation.

  3. A RETROSPECTIVE STUDY OF BILATERAL ALVEOLAR BONE GRAFTING

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective. To evaluate the treatment results of bilateral alveolar bone grafting (BABG) in patients with bilateral complete clefts of lip and palate.Methods. A retrospective study was performed in 66 bilateral complete cleft lip and palate patients who received the procedure of BABG, among them 15 were primary BABG and 51 were secondary BABG. The patients were further divided into three groups according to age and eruption stage of the canine at the time of surgery. The result of BABG was evaluated on the radiographs. Results. (1)The overall success rate of BABG was 75.0%, with 83.3% and 72.5% for primary and secondary BABG respectively; (2)The marginal bone level was found to be significantly higher in the youngest age group than in the other groups both for primary and secondary BABG; (3)For both primary and secondary BABG, Group C (patients' age more than 16 years) had the least optimal success rate, with 66.7% and 65.4% respectively. Conclusion. Simultaneous primary palate repair and BABG is safe and feasible procedure for treating unoperated bilateral complete cleft lip and cleft palate patients. For both primary and secondary BABG, significantly better results can be achieved if the operation is performed before eruption of the canine.

  4. A plasmapheresis protocol for refractory pulmonary alveolar proteinosis.

    Science.gov (United States)

    Garber, Bryan; Albores, Jeffrey; Wang, Tisha; Neville, Thanh H

    2015-04-01

    Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of proteinaceous material within the lungs. While typically managed with whole lung lavage (WLL), more recent PAP therapies aimed at reducing granulocyte-macrophage colony stimulating factor autoantibodies (anti-GM-CSF) have reduced symptoms and improved lung function. We present a patient with PAP refractory to WLL, exogenous GM-CSF and rituximab who underwent a novel plasmapheresis protocol as a therapeutic trial. While previously reported regimens have utilized plasmapheresis sessions distributed over months, our patient underwent five consecutive days of plasmapheresis, followed by rituximab. Anti-GM-CSF levels decreased from 24.8 to 2.7 mcg/mL post-plasmapheresis. This reduction of autoantibody correlated with reduction in WLL frequency, increase in diffusing capacity for carbon monoxide, and subjective improvement in dyspnea. Our case suggests that five consecutive days of plasmapharesis results in increased clearance of anti-GM-CSF and may be potentially efficacious in cases of refractory PAP. PMID:25557091

  5. Clinical significance of serum lipids in idiopathic pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    Fang Cun S

    2012-01-01

    Full Text Available Abstract Background It is well known that pulmonary alveolar proteinosis(PAP is characterised by accumulation of surfactant lipids and proteins within airspaces. However, few previous data describe the serum lipid levels associated with PAP. Materials and methods We retrospectively reviewed 25 patients with idiopathic PAP(iPAP. The serum lipid levels of patients with idiopathic PAP were compared with those of the healthy volunteers. In patients and healthy subjects, the LDL-C/HDL-C ratios were 2.94 ± 1.21 and 1.60 ± 0.70, respectively (p p A-aO2 (r = -0.685, p = 0.003, and r = 0.688, p = 0.003, respectively. The values of LDL-C/HDL-C ratios also correlated with PaO2 levels and PA-aO2 levels (r = -0.698, p = 0.003, and r = 0.653, p = 0.006, respectively. 11 and 13 patients experienced respectively a decline in TC and LDL-C levels following whole lung lavage(WLL, the median decline was 0.71 mmol/L(p p Conclusions the serum lipid levels, especially the levels of LDL-C and LDL-C/HDL-C, may reflect the severity of the disease in PAP patients, and predict the therapeutic effect of WLL.

  6. Trace elements in human alveolar macrophages studied by PIXE

    Science.gov (United States)

    Weber, G.; Roelandts, I.; Corhay, J. L.; Radermecker, M.; Delavignette, J. P.

    1990-04-01

    The purpose of this study is to determine the metal content of alveolar macrophages by PIXE from 94 subjects divided into two groups as follows: group (1) — subjects with non-occupational exposure to industrial dust: 30 healthy volunteers (controls), 16 patients suffering from lung cancer; group (2) — 48 healthy steel workers from the Liège area (blast-furnace [ n=29] and coke oven [ n=19]). We hope to define more precisely the influence of carcinoma, smoking habit, pathology and occupational exposure in the steel industry on the macrophage metal content. This study has shown: (a) an Fe and Sr increase and a Br decrease in the macrophages of smokers (especially in heavy smokers): (b) a significant Fe, Ti, Br and Cu increase and a trend to Pb, Cr, As and Sr increase in macrophages of healthy steel workers (especially blast-furnace workers) in comparison with non-exposed controls; (c) a significant Fe, Br, Cu and Zn increase and a trend to Pb, As and Ni increase in macrophages of non-exposed patients with lung cancer by comparison with non-exposed controls. The mechanism of metal change could be explained by professional exposure and endogenous changes (protein synthesis, inflammation, bronchial bleeding, …)

  7. Alveolar Ridge Preservation Using Xenogeneic Collagen Matrix and Bone Allograft

    Directory of Open Access Journals (Sweden)

    Andreas O. Parashis

    2014-01-01

    Full Text Available Alveolar ridge preservation (ARP has been shown to prevent postextraction bone loss. The aim of this report is to highlight the clinical, radiographic, and histological outcomes following use of a bilayer xenogeneic collagen matrix (XCM in combination with freeze-dried bone allograft (FDBA for ARP. Nine patients were treated after extraction of 18 teeth. Following minimal flap elevation and atraumatic extraction, sockets were filled with FDBA. The XCM was adapted to cover the defect and 2-3 mm of adjacent bone and flaps were repositioned. Healing was uneventful in all cases, the XCM remained in place, and any matrix exposure was devoid of further complications. Exposed matrix portions were slowly vascularized and replaced by mature keratinized tissue within 2-3 months. Radiographic and clinical assessment indicated adequate volume of bone for implant placement, with all planned implants placed in acceptable positions. When fixed partial dentures were placed, restorations fulfilled aesthetic demands without requiring further augmentation procedures. Histological and immunohistochemical analysis from 9 sites (4 patients indicated normal mucosa with complete incorporation of the matrix and absence of inflammatory response. The XCM + FDBA combination resulted in minimal complications and desirable soft and hard tissue therapeutic outcomes, suggesting the feasibility of this approach for ARP.

  8. Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis

    Directory of Open Access Journals (Sweden)

    Xu Wenbing

    2011-04-01

    Full Text Available Abstract Background It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP. It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP. Methods and Results Clinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (P25: 104.36, P75: 219.00 vs 119.56 mg/dl (P25: 78.81, P75: 193.03, P vs 51.34 ± 12.06 mg/dl, P 2 (r = -0.403, P P Conclusions PAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.

  9. Uptake of palmitic acid by rabbit alveolar type II cells

    International Nuclear Information System (INIS)

    Alveolar type II cells require a source of palmitic acid for synthesis of dipalmitoyl phosphatidylcholine (DPPC), a major constituent of pulmonary surfactant. Previous studies indicated that maximal rates of DPPC synthesis are achieved only if exogenous palmitate is available to the type II cell. Little is known of the mechanisms by which fatty acids enter type II cells. To determine if uptake is mediated by a membrane carrier system, as described in other cell types, we examined the kinetics of palmitate uptake. Using freshly isolated rabbit type II cells, we demonstrated that radiolabeled palmitate uptake was maximal and linear for 45 s; after 1 min the apparent rate of uptake declined. The initial uptake phase was taken as a measure of cellular fatty acid influx because intracellular radiolabeled palmitate remained 80% nonesterified at this time but was 55% esterified by 2 min. Cellular influx of palmitate showed saturation kinetics with increasing concentration of nonalbumin bound palmitate. Michaelis constant was 52.6 nM, and maximum velocity was 152 pmol.10(6) cells-1.min-1. The hypothesis that saturable cellular influx of palmitate is likely linked to the previously identified membrane fatty acid binding protein (MFABP) was supported by Western-blot analysis of rat lung tissue with an antibody to MFABP that demonstrated the presence of this carrier protein in lung tissue. These data suggest that palmitate uptake by type II cells is saturable and may be mediated by a membrane-associated carrier as described in other cell types

  10. Pulmonary alveolar proteinosis: Quantitative CT and pulmonary functional correlations

    International Nuclear Information System (INIS)

    Objective: We assessed the relationship between quantitative computer tomography (qCT) and the pulmonary function test (PFT) or blood gas analysis in pulmonary alveolar proteinosis (PAP) patients, as well as the utility of these analyses to monitor responses to whole lung lavage (WLL) therapy. Methods: Thirty-eight PAP patients simultaneously received a CT scan and PFT. Fifteen of these patients, undergoing sequential WLL for a total of 20 lavages, also underwent chest CT scans and blood gas analysis before and after WLL, and 14 of 15 patients underwent simultaneous PFT analysis. Differences between the qCT and PFT results were analyzed by canonical correlation. Results: PAP patients with low predicted values for FVC, FEV1, DLCO and DLCO/VA indicated small airspace volume and mean lung inflation, low airspace volume/total lung volume ratio and high mean lung density. Correlation and regression analysis revealed a strong correlation between DLCO and PaO2 values with CT results. The qCT results indicated that WLL significantly decreased lung weights and mean lung densities, and improved the total airspace volume/total lung volume ratios and mean lung inflations. Conclusion: Quantitative CT may be a sensitive tool for measuring the response of PAP patients to medical interventions such as WLL

  11. Determinants of alveolar ridge preservation differ by anatomic location

    Science.gov (United States)

    Leblebicioglu, Binnaz; Salas, Mabel; Ort, Yirae; Johnson, Ashley; Yildiz, Vedat O.; Kim, Do-Gyoon; Agarwal, Sudha; Tatakis, Dimitris N.

    2016-01-01

    Aim To investigate and compare outcomes following alveolar ridge preservation (ARP) in posterior maxilla and mandible. Methods Twenty-four patients (54 ± 3 years) with single posterior tooth extraction were included. ARP was performed with freeze-dried bone allograft and collagen membrane. Clinical parameters were recorded at extraction and re-entry. Harvested bone cores were analysed by microcomputed tomography (micro-CT), histomorphometry and immunohistochemistry. Results In both jaws, ARP prevented ridge height loss, but ridge width was significantly reduced by approximately 2.5 mm. Healing time, initial clinical attachment loss and amount of keratinized tissue at extraction site were identified as determinants of ridge height outcome. Buccal plate thickness and tooth root length were identified as determinants of ridge width outcome. In addition, initial ridge width was positively correlated with ridge width loss. Micro-CT revealed greater mineralization per unit volume in new bone compared with existing bone in mandible (p < 0.001). Distributions of residual graft, new cellular bone and immature tissue were similar in both jaws. Conclusion Within the limitations of this study, the results indicate that in different anatomic locations different factors may determine ARP outcomes. Further studies are needed to better understand determinants of ARP outcomes. PMID:23432761

  12. ANALISIS PENGARUH MANAJEMEN LABA TERHADAP NILAI PERUSAHAAN SEBELUM DAN SAAT IMPLEMENTASI IFRS

    Directory of Open Access Journals (Sweden)

    - Ustman

    2016-06-01

    Full Text Available Tujuan penelitian ini untuk mengetahui secara empiris manajemen laba terhadap nilai perusahaan sebelum dan saat implementasi IFRS serta memahami peranan manajemen laba yang dilakukan oleh perusahaan dalam upaya meningkatkan nilai perusahaan. Manajemen laba diproksikan dengan Discretionary Accruals, dengan model yang dikembangkan oleh Kothari dan nilai perusahaan yang diproksikan dengan TobinsQ. Metode analisis yang digunakan adalah regresi berganda dengan menggunakan data sekunder. Sampel penelitian terdiri atas 55 perusahaan manufaktur yang terdaftar di BEI tahun 2010-2013. Hasil membuktikan bahwa manajemen laba tidak berpengaruh secara signifikan terhadap nilai perusahaan sebelum dan saat implementasi IFRS. Manajemen laba bukan menjadi strategi perusahaan untuk meningkatkan nilai perusahaan.

  13. Servqual Method: Analisis Kualitas Pelayanan Beauty Advisor Sari Ayu Martha Tilaar

    Directory of Open Access Journals (Sweden)

    Ami Widyastuti

    2012-12-01

    Full Text Available Penelitian ini bertujuan untuk menganalisa kualitas pelayanan beauty advisor Sari Ayu Martha Tilaar guna meningkatkan kualitas pelayanan pada konsumen. Pengambilan data menggunakan skala kualitas pelayanan yang disusun berdasarkan metode Servqual dari (Parasuraman, dkk., 1988 pada 72 orang konsumen Sari Ayu Martha Tilaar. Sampel diambil dengan menggunakan teknik insidental random sampling. Analisis data menggunakan pengukuran gap 5 dari metode Servqual. Hasil penelitian menemukan ada kesenjangan pelayanan (service gap antara persepsi dan harapan konsumen sebesar -81.09 dimana nilai minus disini berarti, kinerja kerja beauty advisor Sari Ayu Martha Tilaar berada pada kategori rendah. Kesimpulannya, beauty advisor sebagai garda lini depan dalam pemasaran belum bekerja secara optimal.

  14. Ruoli pragmatici di "sì" : modello di analisi dei segnali discorsivi nell'italiano parlato

    Directory of Open Access Journals (Sweden)

    Jana Kenda

    2008-12-01

    Full Text Available Nel presente contributo osserveremo i diversi ruoli pragmatici assunti dal segnale discorsivo sì nella lingua italiana parlata. è nostro intento servirci di questo esempio concreto per illustrare la pluralità di funzioni e di forze illocutorie di un segnale discorsivo che possono renderne difficoltosa l’elaborazione e l’interpretazione. il metodo adottato per l’individuazione dei diversi ruoli pragmatici svolti dal segnale prescelto, si propone di costituire un modello di analisi applicabile anche ad altri elementi linguistici aventi simili proprietà pragmatiche.

  15. Analisi della qualità in biblioteca: la soluzione SiMonLib™@CASPUR

    OpenAIRE

    Ugo Contino; Ilaria Fava; Giovanni Solinas

    2011-01-01

    ItLa raccolta periodica di dati e l’analisi delle performance, in un’ottica di valutazione della Qualità del Servizio, sono sicuramente elementi rilevanti per coloro che s’interessino della gestione di una biblioteca o di un sistema bibliotecario. Modi sempre più efficienti e ottimizzati per gestire specifiche campagne di raccolta dati non possono prescindere dall’uso di strumenti in ambito ICT, soprattutto per far fronte ai non banali problemi logistico organizzativi che simili attività di r...

  16. Analisi sui pigmenti di ceramica neolitica tramite tecniche Raman e LIBS

    Directory of Open Access Journals (Sweden)

    Cristina Fabbri

    2007-04-01

    Full Text Available I dati presentati in questo breve contributo provengono da uno studio condotto in collaborazione dal Dipartimento di Scienze Archeologiche dell’Università di Pisa e dall’Istituto per i Processi Chimico-Fisici di Fisica molecolare del CNR di Pisa. Le metodologie applicate sono basate sull’analisi integrata delle tecniche spettroscopiche Raman e LIBS già ampiamente utilizzate nel campo dei Beni Culturali; i metodi sono infatti essenzialmente non distruttivi, non richiedono di un pre trattamento del campione e l’acquisizione delle misure è immediata.

  17. ANALISIS PRODUKSI DAN KONSUMSI PERAJIN RAMBUT DI DESA KARANGBANJAR KECAMATAN BOJONGSARI, PURBALINGGA

    Directory of Open Access Journals (Sweden)

    Agus Arifin

    2016-06-01

    rambut industri kreatif di Karangbanjar, Purbalingga. Penelitian ini menggunakan data primer dan sekunder. Data primer dikumpulkan dari responden—pengusaha industri produksi rambut—sejumlah 68 sampel, dan data sekunder diperoleh dari instansi pemerintah yang terkait. Beberapa pengukuran diaplikasikan dalam penelitian ini. Faktor internal dan eksternal diidentifikasi dengan analisis SWOT, aktivitas produksi diukur dengan analisis keuntungan dan analisis efisiensi ekonomi, sementara perilaku konsumsi diukur dengan analisis APC (Average Propensity to Consume. Hasil penelitian menunjukkan bahwa: 1 industri kreatif kerajinan rambut mempunyai kekuatan lebih banyak daripada kelemahannya dan peluang lebih besar daripada ancamannya; (2 industri kreatif  rambut menawarkan keuntungan yang tinggi; 3 laba pengusaha dari industri ini dapat memenuhi sebagian besar konsumsi.

  18. Il libro di spese diverse di Lorenzo Lotto. Analisi e commento

    OpenAIRE

    De Carolis, Francesco

    2015-01-01

    Il progetto si concentra sull’analisi ed il commento del libro dei conti di Lorenzo Lotto. Esso viene conservato nell’Archivio storico della Santa Casa di Loreto, ed è meglio conosciuto con il nome apocrifo di Libro di spese diverse. Possiamo considerarlo uno dei più significativi documenti del Rinascimento italiano: infatti esso ci parla dei rapporti che l’artista ha intessuto con committenti, colleghi ed amici, rivelando tanto la sua condotta di vita che la sua attività. È una ricerca che t...

  19. ANALISIS PENGARUH CUSTUMER RELATIONSHIP TERHADAP LOYALITAS PELANGGAN DALAM PEMBELIAN SEPEDA MOTOR YAMAHA PADA PT. MEGATAMA MOTOR DI MAKASSAR

    OpenAIRE

    ARDIYHANTO, DIDI

    2012-01-01

    ABSTRAK DIDI ARDIYHANTO. A211 07 608. Analisis Pengaruh Custumer Relationship Terhadap Loyalitas Pelanggan dalam Pembelian Sepeda Motor Yamaha Pada PT. Megatama Motor di Makassar. (dibimbing oleh Yansor Djaya dan Indriyanti Sudirman) Tujuan dari penelitian ini adalah untuk melihat sejauh mana pengaruh customer relationship yang dilakukan oleh perusahaan PT. Megatama Motor di Makassar terhadap loyalitas pelanggan dan untuk menganalisis variabel customer relationship yang pa...

  20. Analisis dan Desain BI-Dashboard Monitoring Realisasi Daftar Isian Pelaksanaan Anggaran (DIPA) pada Kantor Pelayanan Perbendaharaan Negara (KPPN)

    OpenAIRE

    Ernestina Rahmanasari; Rully A Hendrawan; Siswanto Siswanto

    2013-01-01

    Transaksi keuangan badan pemerintahan tingkat daerah dipertanggungjawabkan kepada Kementrian Keuangan melalui Kantor Pelayanan Perbendaharaan Negara (KPPN)setiap bulan dalam bentuk Laporan Keuangan Pemerintah Pusat (LKPP). Laporan Keuangan, didukung dengan teknologi Business Intelligence(BI) dashboarddapat dimanfaatkan sebagai data-driven decision support system yang mendorong performa kinerja. Analisis dan desainterhadap pembuatan BI dashboard menunjukkanbagaimana Laporan Keuangan dapat digu...

  1. Analisis Kelayakan Teknis Dan Finansial Produksi Maltodekstrin Dari Pati Hipokotil Bruguiera gymnorrhiza Di Kabupaten Seram Bagian Barat.

    Directory of Open Access Journals (Sweden)

    Melkhianus H. Pentury

    2013-06-01

    Full Text Available Pemanfaatan pati dari hipokotil Bruguiera gymnorrhiza sebagai bahan baku dalam produksi maltodekstrin dapat meningkatkan nilai ekonomis Bruguiera gymnorrhiza. Penelitian ini bertujuan untuk analisis kelayakan teknis dan finansial dalam memproduksi maltodekstrin dari hipokotil Bruguiera gymnorrhiza di Kabupaten Seram Barat. Skala industri maltodekstrin dirancang pada kapasitas produksi 100kg per hari, atau 27.000kg maltodekstrin per tahun. Lokasi produksi dilakukan di desa pesisir Kotania, Kabupaten Seram Barat, daerah tersebut merupakan Zona Ekonomi Khusus (ZEK di Kabupaten Seram Barat, wilayah tersebut merupakan penghasil hipokotil Bruguiera gymnorrhiza. Metode hidrolisis enzimatik merupakan teknologi dalam produksi ini. Neraca kesetimbangan menunjukkan hasil produksi sebesar 94%. Perhitungan keuangan menunjukkan perlu invertasi Rp. 113.355.000. berdasarkan analisis kriteria investasi, industri ini layak untuk dikembangkan di Kabupaten Seram Barat. Nilai Net Present Value (NVP 303 635 357 ; IPP 64,6%. Nilai Playback Period (PP investasi pengembangan usaha adalah 5 tahun. B/C rasio sebesar 2,68. Analisis sensitifitas menunjukkan toleransi produksi mengalami penurunan sebesar 20%, produksi maltodekstrin masih cukup layak meskipun keuntungan bersih mengalami penurunan secara signifikan. Produksi maltodekstrin dipengaruhi oleh perubahan pada produksi, dan tidak dipengaruhi oleh harga enzim. Kata kunci: analisis kelayakan, Bruguiera gymnorhiza, maltodekstrin, pati

  2. ANALISIS GANGGUAN DENSITAS MASSA TULANG PENDERITA EPILEPSI YANG MENDAPAT PENGOBATAN FENITOIN DAN ATAU FENOBARBITAL DENGAN MORFOMETRI METAKARPAL

    OpenAIRE

    dr. Jumraini T, S.Ked.

    2004-01-01

    Penelitian ini bertujuan untuk menganalisis gangguan densitas massa tulang (DMT) penderita epilepsi yang mendapat pengobatan fenitoin dan atau fenobarbital jangka panjang dan hubungannya dengan umur, jenis kelamin, dan lama pengobatan. Penelitian ini bersifat deskriptif analisis Cross Sectional Styudy yang dilakukan ter-hadap 60 sampel. Penilaian DMT dengan morfometri metakarpal dilakukan setelah mengeksklusi penyakit yang dapat menimbulkan gangguan DMT. Untuk melihat hubungan digunakan ...

  3. Analisis Safety System dan Manajemen Risiko pada Steam Boiler PLTU di Unit 5 Pembangkitan Paiton, PT. YTL

    Directory of Open Access Journals (Sweden)

    Luluk Kristianingsih

    2013-09-01

    Full Text Available Pembangkit listrik tenaga uap (PLTU merupakan pembangkit listrik yang banyak digunakan di Indonesia. Salah satu bagian dari sistem PLTU yang memiliki risiko bahaya tinggi adalah boiler, oleh karena itu diperlukan adanya analisis bahaya dan safety system sebagai langkah pencegahan bahaya pada boiler. Analisis bahaya dalam penelitian ini dilakukan menggunakan metode HAZOP. Node yang dipakai adalah economizer, steam drum, superheater, dan reheater yang merupakan komponen utama penyusun boiler. Guide word dan deviasi ditentukan berdasarkan control chart yang dibentuk oleh data proses masing-masing komponen selama bulan Maret 2013. Estimasi likelihood dilakukan berdasarkan data maintenance dari work order PT YTL selama 5 tahun, sedangkan estimasi consequences dilakukan berdasarkan kriteria risiko yang ditimbulkan serta berdasarkan control chart. Hasil perkalian likelihood dan consequences dengan risk matrix menghasilkan kriteria risiko dari komponen. Berdasarkan hasil analisis, diperoleh hasil bahwa komponen yang memiliki risiko bahaya paling besar adalah level transmitter steam drum dengan deviasi berupa less level, yaitu dengan kriteria likelihood adalah A dan consequences 4, sehingga risiko bernilai extreme. Selain itu, risiko extreme juga terdapat pada pressure transmitter outlet superheater, dengan likelihood B dan consequences 4. Untuk menurunkan risiko, maka dilakukan perawatan dan kalibrasi secara rutin, serta penambahan redundant transmitter. Bahaya paling besar pada seluruh node adalah adanya kebakaran. Oleh karena itu, dilakukan analisis emergency response plan untuk kebakaran yang mencakup peta evakuasi, tugas dan tanggungjawab tiap personel, langkah pencegahan, serta langkah penanganan.

  4. Anaesthesia for serial whole-lung lavage in a patient with severe pulmonary alveolar proteinosis: a case report

    OpenAIRE

    Webb Stephen T; Evans Adrian JR; Varley A James; Klein Andrew A

    2008-01-01

    Abstract Introduction Pulmonary alveolar proteinosis is a rare condition that requires treatment by whole-lung lavage. We report a case of severe pulmonary alveolar proteinosis and discuss a safe and effective strategy for the anaesthetic management of patients undergoing this complex procedure. Case presentation A 34-year-old Caucasian man was diagnosed with severe pulmonary alveolar proteinosis. He developed severe respiratory failure and subsequently underwent serial whole-lung lavage. Our...

  5. In-Vivo Effect of Andrographolide on Alveolar Bone Resorption Induced by Porphyromonas gingivalis and Its Relation with Antioxidant Enzymes

    OpenAIRE

    Rami Al Batran; Fouad H. Al-Bayaty; Mazen M.Jamil Al-Obaidi

    2013-01-01

    Alveolar bone resorption is one of the most important facts in denture construction. Porphyromonas gingivalis (Pg) causes alveolar bone resorption, and morphologic measurements are the most frequent methods to identify bone resorption in periodontal studies. This study has aimed at evaluating the effect of Andrographolide (AND) on alveolar bone resorption in rats induced by Pg. 24 healthy male Sprague Dawley rats were divided into four groups as follows: normal control group and ...

  6. Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability

    OpenAIRE

    Halter, Jeffrey M; Steinberg, Jay M; Gatto, Louis A; DiRocco, Joseph D; Pavone, Lucio A; Schiller, Henry J.; Albert, Scott; Lee, Hsi-Ming; Carney, David; Nieman, Gary F.

    2007-01-01

    Introduction One potential mechanism of ventilator-induced lung injury (VILI) is due to shear stresses associated with alveolar instability (recruitment/derecruitment). It has been postulated that the optimal combination of tidal volume (Vt) and positive end-expiratory pressure (PEEP) stabilizes alveoli, thus diminishing recruitment/derecruitment and reducing VILI. In this study we directly visualized the effect of Vt and PEEP on alveolar mechanics and correlated alveolar stability with lung ...

  7. Transmission of Values pada Serial Drama Korea Bread, Love, and Dreams (Analisis Isi Tayangan Serial Drama Korea dan Penyebaran Nilai-nilai Sosial di Dalamnya)

    OpenAIRE

    Simangunsong, Eva Friska

    2011-01-01

    Serial drama Bread, Love, and Dreams yang merupakan subjek penelitian kali ini diproduksi oleh KBS2 (Korean Broadcasting System) Seoul ditayangkan perdana pada 20 Desember 2010 di Indonesia oleh Indosiar. Penelitian dilakukan dengan metode Analisis Isi Kualitatif. Analisis isi media kualitatif lebih banyak dipakai untuk meneliti dokumen yang dapat berupa teks, gambar, simbol dan sebagainya untuk memahami budaya dari suatu konteks sosial tertentu. Langkah kerjanya dimulai dengan menemukan lamb...

  8. Analisis Perbandingan Sistem Pemberian Kredit Pada Bank Konvensional (PT. Bank Cimb Niaga) Dan Sistem Pembiayaan Murabahah Pada Bank Syariah (PT. Bank Cimb Niaga Syariah) Di Medan

    OpenAIRE

    Kardina, Tika

    2011-01-01

    Tujuan penelitian ini adalah untuk mengetahui sistem pembiayaan KPR (Kredit Pemilikan Rumah) bank konvensional khususnya Bank CIMB Niaga dan sistem Pembiayaan kepemilikan Rumah (PKR) khususnya Bank CIMB Niaga Syariah di Medan. Metode Analisis data yang digunakan dalam penelitian ini adalah metode analisis deskriptif, yaitu data yang dikumpulkan mula-mula disusun, diklasifikasikan, dan dianalisis sehingga akan memberikan gambaran yang jelas mengenai sistem pembiayaan KPR di bank konvensional d...

  9. Analisis Pengaruh Cash Position, Debt To Equity Ratio Dan Return On Assets Terhadap Dividend Payout Ratio Pada Perusahaan Manufaktur Di Bursa Efek Indonesia

    OpenAIRE

    Clara Danica

    2009-01-01

    Penelitian ini bertujuan untuk menguji dan menganalisis faktor-faktor yang mempengaruhi Dividend Payout Ratio pada sektor manufaktur di Bursa Efek Indonesia (BEI). Pada penelitian ini digunakan analisis fundamental perusahaan melalui analisis rasio keuangan, dimana rasio likuiditas diwakili oleh Cash Position, rasio leverage diwakili oleh Debt to Equity Ratio (DER) dan rasio profitabilitas diwakili oleh Return on Assets (ROA) dan rasio pasar diwakili oleh Dividend Payout Ratio (DPR). Periode ...

  10. ANALISIS DESKRIPTIF DALAM PENERAPAN MODEL PEMBELAJARAN PBL (PROBLEM BASED LEARNING) OLEH GURU MATA PELAJARAN EKONOMI SMA NEGERI 1 SLIYEG KABUPATEN INDRAMAYU

    OpenAIRE

    Sheilla Az Zahra; Widiyanto

    2015-01-01

    Permasalahan dalam penelitian ini antara lain : (1) Perencanaan pembelajaran PBL oleh guru Ekonomi (2) Pelaksanaan pembelajaran PBL oleh guru Ekonomi di SMAN 1 Sliyeg (3) Evaluasi pembelajaran PBL oleh guru Ekonomi. Metode yang digunakan dalam penelitian ini adalah metode kualitatif. Penelitian ini dilaksanakan di SMA Negeri 1 Sliyeg Kabupaten Indramayu. Alat analisis data adalah analisis interaksi. Teknik pengumpulan data menggunakan wawancara dan dokumentasi. Informan utama adalah guru mata...

  11. Effects of oestrogen deficiency on the alveolar bone of rats with experimental periodontitis.

    Science.gov (United States)

    Xu, Xin-Chen; Chen, Hui; Zhang, Xi; Zhai, Zan-Jing; Liu, Xu-Qiang; Zheng, Xin-Yi; Zhang, Jun; Qin, An; Lu, Er-Yi

    2015-09-01

    Periodontitis is an inflammatory disease characterized by loss of connective tissue and alveolar bone, and osteoporosis is a common disease characterized by a systemic impairment of bone mass and microarchitecture. To date, the association between periodontitis and osteoporosis has remained to be fully elucidated. In the present study, an experimental rat model of periodontitis was used to explore the effects of oestrogen deficiency‑induced osteoporosis on the maxillary alveolar bone. Forty‑four female, six‑month‑old Sprague‑Dawley rats were randomly divided into four groups: Control, ligature, ovariectomized (OVX), and OVX + ligature. One month after ovariectomy, rats in the ligature and OVX + ligature groups received ligatures on their first and second maxillary molars for 1 month. Fluorescent labelling was performed prior to sacrificing the animals. At the end of the experiment, the maxillae and serum were collected and subjected to micro‑computed tomography analysis, confocal laser‑scanning microscopic observation, Van Gieson's fuchsin staining, tartrate‑resistant acid phosphatase staining and ELISA. Ligatures slightly reduced the alveolar bone mineral density (BMD) and bone formation rate, but significantly reduced alveolar crest height (ACH). Ovariectomy reduced the alveolar BMD, impaired the trabecular structure, reduced the bone formation rate and increased the serum levels of bone resorption markers. Animals in the OVX + ligature group exhibited a lower alveolar BMD, a poorer trabecular structure, a reduced ACH, a lower bone formation rate and higher serum levels of bone resorption markers compared with those in the control group. The results of the present study showed that ovariectomy enhanced alveolar bone loss and reduced the ACH of rats with experimental periodontitis. Thus, post‑menopausal osteoporosis may influence the progression of periodontitis.

  12. Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization.

    Science.gov (United States)

    Funke, Manuela; Knudsen, Lars; Lagares, David; Ebener, Simone; Probst, Clemens K; Fontaine, Benjamin A; Franklin, Alicia; Kellner, Manuela; Kühnel, Mark; Matthieu, Stephanie; Grothausmann, Roman; Chun, Jerold; Roberts, Jesse D; Ochs, Matthias; Tager, Andrew M

    2016-07-01

    Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, contributes to both the development and the pathological remodeling after injury of many organs. Because we found previously that LPA-LPA1 signaling contributes to pulmonary fibrosis, here we investigated whether this pathway is also involved in lung development. Quantitative assessment of lung architecture of LPA1-deficient knock-out (KO) and wild-type (WT) mice at 3, 12, and 24 weeks of age using design-based stereology suggested the presence of an alveolarization defect in LPA1 KO mice at 3 weeks, which persisted as alveolar numbers increased in WT mice into adulthood. Across the ages examined, the lungs of LPA1 KO mice exhibited decreased alveolar numbers, septal tissue volumes, and surface areas, and increased volumes of the distal airspaces. Elastic fibers, critical to the development of alveolar septa, appeared less organized and condensed and more discontinuous in KO alveoli starting at P4. Tropoelastin messenger RNA expression was decreased in KO lungs, whereas expression of matrix metalloproteinases degrading elastic fibers was either decreased or unchanged. These results are consistent with the abnormal lung phenotype of LPA1 KO mice, being attributable to reduced alveolar septal formation during development, rather than to increased septal destruction as occurs in the emphysema of chronic obstructive pulmonary disease. Peripheral septal fibroblasts and myofibroblasts, which direct septation in late alveolarization, demonstrated reduced production of tropoelastin and matrix metalloproteinases, and diminished LPA-induced migration, when isolated from LPA1 KO mice. Taken together, our data suggest that LPA-LPA1 signaling is critically required for septation during alveolarization. PMID:27082727

  13. Analisis Karakteristik Wacana Kritis dalam Novel ونسيت انى إمراة /wa nasîtu annî imra´ah/ “Aku Lupa Bahwa Aku Perempuan” Karya Ihsan Abdul Qudus

    OpenAIRE

    Apediani, Sri

    2010-01-01

    Penelitian ini membahas tentang karakteristik analisis wacana kritis dalam novel Aku Lupa Bahwa Aku Perempuan karya Ihsan Abdul Qudus. Karakteristik analisis wacana kritis menggambarkan wacana sebagai praktik sosial dan menyebabkan sebuah hubungan dialektis diantara peristiwa tertentu dengan situasi, institusi, dan struktur sosial yang membentuknya. Permasalahan yang diteliti adalah karakteristik analisis wacana kritis yang terdiri dari lima bagian yaitu tindakan, konteks, historis, kekua...

  14. Alveolocapillary model system to study alveolar re-epithelialization

    Energy Technology Data Exchange (ETDEWEB)

    Willems, Coen H.M.P.; Zimmermann, Luc J.I.; Sanders, Patricia J.L.T.; Wagendorp, Margot; Kloosterboer, Nico [Department of Paediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Maastricht (Netherlands); Cohen Tervaert, Jan Willem [Division of Clinical and Experimental Immunology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht (Netherlands); Duimel, Hans J.Q.; Verheyen, Fons K.C.P. [Electron Microscopy Unit, Department of Molecular Cell Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Iwaarden, J. Freek van, E-mail: f.vaniwaarden@maastrichtuniversity.nl [Department of Paediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Maastricht (Netherlands)

    2013-01-01

    In the present study an in vitro bilayer model system of the pulmonary alveolocapillary barrier was established to investigate the role of the microvascular endothelium on re-epithelialization. The model system, confluent monolayer cultures on opposing sides of a porous membrane, consisted of a human microvascular endothelial cell line (HPMEC-ST1.6R) and an alveolar type II like cell line (A549), stably expressing EGFP and mCherry, respectively. These fluorescent proteins allowed the real time assessment of the integrity of the monolayers and the automated analysis of the wound healing process after a scratch injury. The HPMECs significantly attenuated the speed of re-epithelialization, which was associated with the proximity to the A549 layer. Examination of cross-sectional transmission electron micrographs of the model system revealed protrusions through the membrane pores and close contact between the A549 cells and the HPMECs. Immunohistochemical analysis showed that these close contacts consisted of heterocellular gap-, tight- and adherens-junctions. Additional analysis, using a fluorescent probe to assess gap-junctional communication, revealed that the HPMECs and A549 cells were able to exchange the fluorophore, which could be abrogated by disrupting the gap junctions using connexin mimetic peptides. These data suggest that the pulmonary microvascular endothelium may impact the re-epithelialization process. -- Highlights: ► Model system for vital imaging and high throughput screening. ► Microvascular endothelium influences re-epithelialization. ► A549 cells form protrusions through membrane to contact HPMEC. ► A549 cells and HPMECs form heterocellular tight-, gap- and adherens-junctions.

  15. Human alveolar echinococcosis in Poland: 1990-2011.

    Directory of Open Access Journals (Sweden)

    Wacław L Nahorski

    Full Text Available BACKGROUND: Alveolar echinococcosis (AE caused by Echinococcus multilocularis infections is a dangerous old disease in the Northern Hemisphere. The aim of the paper was to collect and analyze data on human AE in Poland in the last two decades. METHODOLOGY/PRINCIPAL FINDINGS: The sources of data were both the cases officially registered and detected by an active field and laboratory surveillance. The cases were verified by clinical, epidemiological, and laboratory criteria. Altogether 121 human cases of AE were detected. Among these 83 (68,6% cases were classified as confirmed, 16 as probable and 22 as possible. During the two decades a continuous increase in detection rate was noticed. The cases were 6-82 years old at the time of diagnosis (mean - 47.7 years. Sex ratio M/F was 0.86/1.0. The AE was fatal in 23 (19% patients (mean age at death - 54.1 years. Family agglomeration of AE was found in 4 foci, involving 9 patients. Seventy six of the cases were diagnosed in an advanced stage of disease. In all cases the liver was the primary location of AE. In 30 (24.8% patients a spread to other organs was observed. Ninety four of the patients were treated with albendazole. In 73 (60% patients a surgical operation was performed, including 15 liver transplantations. CONCLUSIONS/SIGNIFICANCE: The studies confirmed that AE is an emerging disease in Poland, which is the fourth country in Europe with over 120 cases detected. The results also indicate the need of a wider national programme for implementation of screening in the highest AE risk areas (north-eastern Poland with an effort to increase the public awareness of the possibility of contracting E. multilocularis, and above all, training of the primary care physicians in the recognition of the risk of AE to allow for an early detection of this dangerous disease.

  16. Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

    Science.gov (United States)

    Szafranski, Przemyslaw; Gambin, Tomasz; Dharmadhikari, Avinash V; Akdemir, Kadir Caner; Jhangiani, Shalini N; Schuette, Jennifer; Godiwala, Nihal; Yatsenko, Svetlana A; Sebastian, Jessica; Madan-Khetarpal, Suneeta; Surti, Urvashi; Abellar, Rosanna G; Bateman, David A; Wilson, Ashley L; Markham, Melinda H; Slamon, Jill; Santos-Simarro, Fernando; Palomares, María; Nevado, Julián; Lapunzina, Pablo; Chung, Brian Hon-Yin; Wong, Wai-Lap; Chu, Yoyo Wing Yiu; Mok, Gary Tsz Kin; Kerem, Eitan; Reiter, Joel; Ambalavanan, Namasivayam; Anderson, Scott A; Kelly, David R; Shieh, Joseph; Rosenthal, Taryn C; Scheible, Kristin; Steiner, Laurie; Iqbal, M Anwar; McKinnon, Margaret L; Hamilton, Sara Jane; Schlade-Bartusiak, Kamilla; English, Dawn; Hendson, Glenda; Roeder, Elizabeth R; DeNapoli, Thomas S; Littlejohn, Rebecca Okashah; Wolff, Daynna J; Wagner, Carol L; Yeung, Alison; Francis, David; Fiorino, Elizabeth K; Edelman, Morris; Fox, Joyce; Hayes, Denise A; Janssens, Sandra; De Baere, Elfride; Menten, Björn; Loccufier, Anne; Vanwalleghem, Lieve; Moerman, Philippe; Sznajer, Yves; Lay, Amy S; Kussmann, Jennifer L; Chawla, Jasneek; Payton, Diane J; Phillips, Gael E; Brosens, Erwin; Tibboel, Dick; de Klein, Annelies; Maystadt, Isabelle; Fisher, Richard; Sebire, Neil; Male, Alison; Chopra, Maya; Pinner, Jason; Malcolm, Girvan; Peters, Gregory; Arbuckle, Susan; Lees, Melissa; Mead, Zoe; Quarrell, Oliver; Sayers, Richard; Owens, Martina; Shaw-Smith, Charles; Lioy, Janet; McKay, Eileen; de Leeuw, Nicole; Feenstra, Ilse; Spruijt, Liesbeth; Elmslie, Frances; Thiruchelvam, Timothy; Bacino, Carlos A; Langston, Claire; Lupski, James R; Sen, Partha; Popek, Edwina; Stankiewicz, Paweł

    2016-05-01

    Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV. We describe novel deletion CNVs at the FOXF1 locus in 13 unrelated ACDMPV patients. Together with the previously reported cases, all 31 genomic deletions in 16q24.1, pathogenic for ACDMPV, for which parental origin was determined, arose de novo with 30 of them occurring on the maternally inherited chromosome 16, strongly implicating genomic imprinting of the FOXF1 locus in human lungs. Surprisingly, we have also identified four ACDMPV families with the pathogenic variants in the FOXF1 locus that arose on paternal chromosome 16. Interestingly, a combination of the severe cardiac defects, including hypoplastic left heart, and single umbilical artery were observed only in children with deletion CNVs involving FOXF1 and its upstream enhancer. Our data demonstrate that genomic imprinting at 16q24.1 plays an important role in variable ACDMPV manifestation likely through long-range regulation of FOXF1 expression, and may be also responsible for key phenotypic features of maternal uniparental disomy 16. Moreover, in one family, WES revealed a de novo missense variant in ESRP1, potentially implicating FGF signaling in the etiology of ACDMPV.

  17. Cell culture models using rat primary alveolar type I cells.

    Science.gov (United States)

    Downs, Charles A; Montgomery, David W; Merkle, Carrie J

    2011-10-01

    There is a lack of cell culture models using primary alveolar type I (AT I) cells. The purpose of this study was to develop cell culture models using rat AT I cells and microvascular endothelial cells from the lung (MVECL). Two types of model systems were developed: single and co-culture systems; additionally a 3-dimensional model system was developed. Pure AT I cell (96.3 ± 2.7%) and MVECL (97.9 ± 1.1%) preparations were used. AT I cell morphology, mitochondrial number and distribution, actin filament arrangement and number of apoptotic cells at confluence, and telomere attrition were characterized. AT I cells maintained their morphometric characteristics through at least population doubling (PD) 35, while demonstrating telomere attrition through at least PD 100. Furthermore, AT I cells maintained the expression of their specific markers, T1α and AQ-5, through PD 42. For the co-cultures, AT I cells were grown on the top and MVECL were grown on the bottom of fibronectin-coated 24-well Transwell Fluroblok™ filter inserts. Neither cell type transmigrated the 1 μm pores. Additionally, AT I cells were grown in a thick layer of Matrigel(®) to create a 3-dimensional model in which primary AT I cells form ring-like structures that resemble an alveolus. The development of these model systems offers the opportunities to investigate AT I cells and their interactions with MVECL in response to pharmacological interventions and in the processes of disease, repair and regeneration. PMID:21624488

  18. Cytokinetic behavior of pulmonary alveolar macrophages in monocytopenic mice

    International Nuclear Information System (INIS)

    The cytokinetic behavior of pulmonary alveolar macrophages (PAM) was studied by pulse labeling with 3HTdB in mice made monocytopenic by a single intravenous injection of the bone-seeking isotope strontium-89 (99Sr). In the presence or absence of blood monocytes, PAM population size was unchanged for up to 1 month of chronic, severe monocytopenia. Pulse-labeling studies performed during monocytopenia show that in control mice PAM population half-times were 17.8 days with a potential doubling time of 39 days, whereas T1/2 was 14.8 days with a 28.5 day population doubling time for PAM in 99Sr-treated mice. Analysis of the halving times of the PAM mean grain count and the halving times of the most highly pulse-labeled cohorts suggested that PAM cell cycle times (Tc) were 5.1 days with a PAM rate of disappearance of 10.8%/day in 99Sr-treated mice and Tc of 6.6 days with a PAM rate of disappearance of 11.4%/day in 99Sr-treated mice. As measured by 3HTdR-labeling techniques, these cytokinetic values are in close approximation to each other, suggesting that 99Sr treatment did not significantly alter either PAM population size or cytokinetic behavior. Employing experimental values it was possible to construct a simple model of PAM population growth that supports the concept that the PAM population is self-renewing in the adult mouse. Taken together, the data show that a major portion of the resident PAM need not depend on the daily influx of peripheral blood monocytes to maintain themselves in a kinetically steady state

  19. Surfactant secretion is stimulated by decreased alveolar CO2

    International Nuclear Information System (INIS)

    The authors investigated the hypothesis that altered intracellular pH may modulate lung surfactant secretion. They have used isolated perfused lung preparation to investigate release of [3H]choline labeled phosphatidylcholine (PC) in the alveolar space of rat lungs ventilated with 5%, 2.5%, or 0% CO2 in air. Adult rats were injected i.p. 40uCi of [3H-methyl] choline and lungs removed after 45 min. Lungs were perfused for 15 or 60 min. with KRB plus 25 mM HEPES. At the end of perfusion lungs were lavaged five times with 7 ml of ice cold saline. Lavage fluid, was centrifuged, lyophilized, and both lung and lavage fluid extracted for lipids. Lipid choline label in lavage fluid, expressed as percent of that in lung lipids, from control lungs (5% CO2) showed 0.6 +/- 0.1 % at 15 min and 1.1 +/- 0.3% (mean +/- SE, n=6) label at 60 min. When perfused with 50 μM 1-isoproterenol, the label after 60 min perfusion increased to 2.76 +/- 0.33 (n=3). Ventilation with air containing 2.5% CO2 and 0% CO2 showed 6.1 +/- 2.1 % (n=4) and 6.4 +/- 1.8% (n=4) label in lavage fluid. Addition of 25mM sodium acetate in the perfusion medium and ventilation with 0% CO2 in air lowered release of label to 4.2 +/- 1.4% (n=4). These results show that low pCO2 increases surfactant PC secretion in lung and suggest that intracellular alkalosis triggers surfactant release

  20. Computed tomography of the alveolar bone; Computertomographie des Alveolarkammes

    Energy Technology Data Exchange (ETDEWEB)

    Schueller, H. [Bonn Univ. (Germany). Radiologische Klinik

    1996-03-01

    In addition to the conventional radiological methods used in odontology, computed tomography (CT) provides superposition-free images of the mandible and maxilla. Its value has been proved not only in cases of malignancy but also in many other problems. If an examination is performed with a slice thickness of less than 1.5 mm, the form and position of retained teeth in the alveolar bone, as well as subsequent lesions of neighboring permanent teeth, can be visualized so that early treatment can be planned. If the parodontal space of a retained tooth is visible, orthodontic intervention is possible. Precise assessment of horizontal or vertical bone loss is essential in inflammatory dental diseases. The morphology and extent of benign cystic lesions are also shown by CT. With CT surgical strategy of an intended implant therapy can take into account the remaining bone substance and the exact position of nerves and foramina. If such therapy is possible, the location, form and number of implants are easily defined. (orig.) [Deutsch] Die Computertomographie ermoeglicht in Ergaenzung zu den in der Zahnheilkunde gebraeuchlichen radiologischen Untersuchungsverfahren eine ueberlagerungsfreie Darstellung von Ober- und Unterkiefer. Neben der bereits etablierten Anwendung der CT bei malignen Erkrankungen hat sich ihr Einsatz bei weiteren Fragestellungen bewaehrt. Wird die Untersuchung mit einer Schichtdicke von weniger als 1,5 mm durchgefuehrt, lassen sich Form und Lage retinierter Zaehne im Kieferknochen und die durch die retinierten Zaehne verursachten Schaeden an bleibenden Zaehnen beurteilen, so dass eine fruehzeitige Therapie moeglich ist. Laesst sich der Parodontalspalt des retinierten Zahnes abgrenzen, ist eine kieferorthopaedische Einordnung moeglich. Bei entzuendlichen Zahnerkrankungen ist der horizontale und vertikale Knochenabbau genau zu bestimmen. Die Morphologie und Ausdehnung von benignen zystischen Raumforderungen ist mit der CT erfassbar. Vor einer beabsichtigten