WorldWideScience

Sample records for alternatives analysis

  1. An alternative analysis of variance

    OpenAIRE

    Longford, Nicholas T.

    2008-01-01

    The one-way analysis of variance is a staple of elementary statistics courses. The hypothesis test of homogeneity of the means encourages the use of the selected-model based estimators which are usually assessed without any regard for the uncertainty about the outcome of the test. We expose the weaknesses of such estimators when the uncertainty is taken into account, as it should be, and propose synthetic estimators as an alternative.

  2. Analysis of supermarket dehumidification alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, J.W. Urban, R.E.; Beckman, W.A.; Dorgan, C.E.; Lindell, C.J. (Wisconsin Univ., Madison, WI (United States). Solar Energy Lab.)

    1992-11-01

    Alternative methods to provide space conditioning in supermarkets were studied. Four basic air-conditioning systems were selected for evaluation in a store in Miami, Florida: (1) conventional vapor compression systems, (2) vapor compression air-conditioning systems designed for supermarket loads, (3) hybrid desiccant air-conditioning systems, and (4) cool storage systems. Computer models were created and annual simulations of performance were made. The impacts on energy use and cost of circulation flow rate, store humidity set point, heat pipe heat exchangers, and climate on energy use and cost were determined. Dual path electric systems and desiccant systems were found to consume the least electrical energy. Savings of the desiccant system are partially offset by natural gas needed to reactivate the desiccant. Single path systems with reduced circulation air flow consumed significantly less electricity than the conventional system. Lower humidity shifts the air-conditioning load from the refrigerated cases to the HVAC system and reduces the electrical use for all but the conventional system. Heat pipe heat exchangers provide little benefit. Flat and time-of-use electric rate schedules were used to estimate operating savings and to determine the cost effectiveness of the alternative approaches.

  3. Economic analysis of alternative LLW disposal methods

    International Nuclear Information System (INIS)

    The Environmental Protection Agency (EPA) has evaluated the costs and benefits of alternative disposal technologies as part of its program to develop generally applicable environmental standards for the land disposal of low-level radioactive waste (LLW). Costs, population health effects and Critical Population Group (CPG) exposures resulting from alternative waste treatment and disposal methods were developed and input into the analysis. The cost-effectiveness analysis took into account a number of waste streams, hydrogeologic and climatic region settings, and waste treatment and disposal methods. Total costs of each level of a standard included costs for packaging, processing, transportation, and burial of waste. Benefits are defined in terms of reductions in the general population health risk (expected fatal cancers and genetic effects) evaluated over 10,000 years. A cost-effectiveness ratio, was calculated for each alternative standard. This paper describes the alternatives considered and preliminary results of the cost-effectiveness analysis

  4. Business System Planning Project, Alternatives Analysis

    International Nuclear Information System (INIS)

    The CHG Chief Information Officer (CIO) requested a study of alternatives to the current business system computing environment. This Business Systems Planning (BSP) Project Alternatives Analysis document presents an analysis of the current Project Controls, Work Management, and Business Management systems environment and alternative solutions that support the business functions. The project team has collected requirements and priorities from stakeholders in each business area and documented them in the BSP System Requirements Specification (SRS), RPP-6297. The alternatives analysis process identifies and measures possible solutions in each of the business process areas against the requirements as documented in the SRS. The team gathered input from both internal and external sources to identify and grade the possible solutions. This document captures the results of that activity and recommends a suite of software products. This study was to select the best product based on how well the product met the requirements, not to determine the platform or hardware environment that would be used. Additional analysis documentation can be found in BSP project files

  5. Economic analysis of alternative LLW disposal methods

    International Nuclear Information System (INIS)

    The Environmental Protection Agency (EPA) has evaluated the costs and benefits of alternative disposal technologies as part of its program to develop generally applicable environmental standards for the land disposal of low-level radioactive waste (LLW). Costs, population health effects and Critical Population Group (CPG) exposures resulting from alternative waste treatment and disposal methods were evaluated both in absolute terms and also relative to a base case (current practice). Incremental costs of the standard included costs for packaging, processing, transportation, and burial of waste. Benefits are defined in terms of reductions in the general population health risk (expected fatal cancers and genetic effects) evaluated over 10,000 years. A cost-effectiveness ratio, defined as the incremental cost per avoided health effect, was calculated for each alternative standard. The cost-effectiveness analysis took into account a number of waste streams, hydrogeologic and climatic region settings, and waste treatment and disposal methods. This paper describes the alternatives considered and preliminary results of the cost-effectiveness analysis. 15 references, 7 figures, 3 tables

  6. Safety relief valve alternate analysis method

    International Nuclear Information System (INIS)

    An experimental test program was started in the United States in 1976 to define and quantify Safety Relief Valve (SRV) phenomena in General Electric Mark I Suppression Chambers. The testing considered several discharged devices and was used to correlate SRV load prediction models. The program was funded by utilities with Mark I containments and has resulted in a detailed SRV load definition as a portion of the Mark I containment program Load Definition Report (LDR). The (USNRC) has reviewed and approved the LDR SRV load definition. In addition, the USNRC has permitted calibration of structural models used for predicting torus response to SRV loads. Model calibration is subject to confirmatory in-plant testing. The SRV methodology given in the LDR requires that transient dynamic pressures be applied to a torus structural model that includes a fluid added mass matrix. Preliminary evaluations of torus response have indicated order of magnitude conservatisms, with respect to test results, which could result in unrealistic containment modifications. In addition, structural response trends observed in full-scale tests between cold pipe, first valve actuation and hot pipe, subsequent valve actuation conditions have not been duplicated using current analysis methods. It was suggested by others that an energy approach using current fluid models be utilized to define loads. An alternate SRV analysis method is defined to correct suppression chamber structural response to a level that permits economical but conservative design. Simple analogs are developed for the purpose of correcting the analytical response obtained from LDR analysis methods. Analogs evaluated considered forced vibration and free vibration structural response. The corrected response correlated well with in-plant test response. The correlation of the analytical model at test conditions permits application of the alternate analysis method at design conditions. (orig./HP)

  7. Alternatives Analysis for the Resumption of Transient Testing Program

    Energy Technology Data Exchange (ETDEWEB)

    Lee Nelson

    2013-11-01

    An alternatives analysis was performed for resumption of transient testing. The analysis considered eleven alternatives – including both US international facilities. A screening process was used to identify two viable alternatives from the original eleven. In addition, the alternatives analysis includes a no action alternative as required by the National Environmental Policy Act (NEPA). The alternatives considered in this analysis included: 1. Restart the Transient Reactor Test Facility (TREAT) 2. Modify the Annular Core Research Reactor (ACRR) which includes construction of a new hot cell and installation of a new hodoscope. 3. No Action

  8. Hydrogen as alternative clean fuel: Economic analysis

    International Nuclear Information System (INIS)

    In analogy to biofuel production from biomasses, the electrolytic conversion of other renewable energies into hydrogen as an alternative clean fuel is considered. This solution allows the intermittent renewable energy sources, as photovoltaics and wind energy, to enhance their development and enlarge the role into conventional fuel market. A rough economic analysis of hydrogen production line shows the costs, added by electrolysis and storage stages, can be recovered by properly accounting for social and environmental costs due to whole cycle of conventional fuels, from production to use. So, in a perspective of attaining the economic competitiveness of renewable energy, the hydrogen, arising from intermittent renewable energy sources, will be able to compete in the energy market with conventional fuels, making sure that their substitution will occur in a significant amount and the corresponding environment

  9. Sodium Bearing Waste Processing Alternatives Analysis

    International Nuclear Information System (INIS)

    A multidisciplinary team gathered to develop a BBWI recommendation to DOE-ID on the processing alternatives for the sodium bearing waste in the INTEC Tank Farm. Numerous alternatives were analyzed using a rigorous, systematic approach. The data gathered were evaluated through internal and external peer reviews for consistency and validity. Three alternatives were identified to be top performers: Risk-based Calcination, MACT to WIPP Calcination and Cesium Ion Exchange. A dual-path through early Conceptual design is recommended for MACT to WIPP Calcination and Cesium Ion Exchange since Risk-based Calcination does not require design. If calcination alternatives are not considered based on giving Type of Processing criteria significantly greater weight, the CsIX/TRUEX alternative follows CsIX in ranking. However, since CsIX/TRUEX shares common uncertainties with CsIX, reasonable backups, which follow in ranking, are the TRUEX and UNEX alternatives. Key uncertainties must be evaluated by the decision-makers to choose one final alternative. Those key uncertainties and a path forward for the technology roadmapping of these alternatives is provided

  10. Sodium Bearing Waste Processing Alternatives Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, James Anthony; Palmer, Brent J; Perry, Keith Joseph

    2003-12-01

    A multidisciplinary team gathered to develop a BBWI recommendation to DOE-ID on the processing alternatives for the sodium bearing waste in the INTEC Tank Farm. Numerous alternatives were analyzed using a rigorous, systematic approach. The data gathered were evaluated through internal and external peer reviews for consistency and validity. Three alternatives were identified to be top performers: Risk-based Calcination, MACT to WIPP Calcination and Cesium Ion Exchange. A dual-path through early Conceptual design is recommended for MACT to WIPP Calcination and Cesium Ion Exchange since Risk-based Calcination does not require design. If calcination alternatives are not considered based on giving Type of Processing criteria significantly greater weight, the CsIX/TRUEX alternative follows CsIX in ranking. However, since CsIX/TRUEX shares common uncertainties with CsIX, reasonable backups, which follow in ranking, are the TRUEX and UNEX alternatives. Key uncertainties must be evaluated by the decision-makers to choose one final alternative. Those key uncertainties and a path forward for the technology roadmapping of these alternatives is provided.

  11. Experiment and Analysis of Car Alternator for Wind Turbine Application

    Directory of Open Access Journals (Sweden)

    Pudji Irasari

    2012-03-01

    Full Text Available This paper discusses experiment and analysis to find out the feasibility of a car alternator to be used as a generator for wind turbine. The experiment was conducted twice. The first experiment was to characterize the alternator to determine the mechanical transmission ratio. In this experiment the alternator was driven by a lathe machine and its output power was supplied to charge a battery. In the second experiment the alternator was integrated with the turbine blades and they were tested as a unit system. In both experiments, the electric generation of alternator was executed with fixed excitation current method. The correlation between the alternator characteristic and the tip speed ratio gives the mechanical transmission ratio of 1 : 3. The experiment results show that the efficiency of alternator is around 50% and cut-in wind speed (after correction is 6.35 m/s indicating that alternator is not feasible for wind turbine system application. 

  12. Supplementary vote; analysis, applications, and alternatives

    NARCIS (Netherlands)

    Kolk, van der Henk

    2008-01-01

    The Supplementary Vote (SV) was invented as a compromise between the two-round runoff system and the alternative vote. This paper shows that in many ways it is not. Under SV voters rank order a limited number of candidates. If one candidate is supported by over 50% of the voters he/she is declared t

  13. Spent Nuclear Fuel Alternative Technology Decision Analysis

    International Nuclear Information System (INIS)

    The Westinghouse Savannah River Company (WSRC) made a FY98 commitment to the Department of Energy (DOE) to recommend a technology for the disposal of aluminum-based spent nuclear fuel (SNF) at the Savannah River Site (SRS). The two technologies being considered, direct co-disposal and melt and dilute, had been previously selected from a group of eleven potential SNF management technologies by the Research Reactor Spent Nuclear Fuel Task Team chartered by the DOE''s Office of Spent Fuel Management. To meet this commitment, WSRC organized the SNF Alternative Technology Program to further develop the direct co-disposal and melt and dilute technologies and ultimately provide a WSRC recommendation to DOE on a preferred SNF alternative management technology

  14. Spent Nuclear Fuel Alternative Technology Decision Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Shedrow, C.B.

    1999-11-29

    The Westinghouse Savannah River Company (WSRC) made a FY98 commitment to the Department of Energy (DOE) to recommend a technology for the disposal of aluminum-based spent nuclear fuel (SNF) at the Savannah River Site (SRS). The two technologies being considered, direct co-disposal and melt and dilute, had been previously selected from a group of eleven potential SNF management technologies by the Research Reactor Spent Nuclear Fuel Task Team chartered by the DOE''s Office of Spent Fuel Management. To meet this commitment, WSRC organized the SNF Alternative Technology Program to further develop the direct co-disposal and melt and dilute technologies and ultimately provide a WSRC recommendation to DOE on a preferred SNF alternative management technology.

  15. Alternative crypto currency analysis and mining

    OpenAIRE

    Ballek, Miroslav

    2014-01-01

    Over the past few years, bitcoin has become a globally successful and much followed project. It is a kind of decentralized digital currency, which functions based on mathematical-cryptographical principles and is created using a computationally intensive process called mining. Thousands of other alternative crypto currencies exist, which have so far stayed unnoticed by the media, even though they outperform bitcoin in many aspects. The central topic of this paper is the extensive ecosystem of...

  16. Competitive Cost Analysis of Alternative Powertrain Technologies.

    OpenAIRE

    Redelbach, Martin; Propfe, Bernd; Friedrich, Horst E.

    2012-01-01

    This paper examines the cost competitiveness of different electrified propulsion technologies from hybrid cars to full battery electric vehicles in the time horizon 2010 to 2020. The assessment shows that the current TCO gaps for alternative drivetrains will increasingly converge over time mainly driven by decreasing production cost. However, the cost-efficiency of different powertrain architectures depends highly on the mileage a user expects to drive per year. In the mid-run, hybrid elec...

  17. Summary: analysis of alternative FBR development strategies

    International Nuclear Information System (INIS)

    This report summarizes the comparative evaluation of alternative strategies for the development of the commercial fast breeder reactor (FBR) in the United States. For planning purposes, a range of possible FBR development paths called strategies were selected for evaluation. These strategies, designed to be technically and economically feasible, were expressed in terms of the timing and nature of facilities/research and development programs required to reach full power operation of the first commercial FBR. Four of the seven strategies resulted in a large (1457 MWe) FBR as an end point, the other three in a 1000-MWe plant. Probability distributions were calculated for total strategy costs and time to completion. For the seven strategies analyzed, the costs (discounted 1980 dollars) ranged from $1.8 billion to $4.9 billion; the completion times ranged from 24 to 55 years

  18. Alternative energy systems design and analysis with induction generators

    CERN Document Server

    Sime̳s, M Godoy

    2011-01-01

    New perspectives on using induction generators in alternative energy technologies Durable and cost-effective, induction power generators have undergone numerous improvements that make them an increasingly attractive option for renewable energy applications, particularly for wind and hydropower generation systems. From fundamental concepts to the latest technologies, Alternative Energy Systems: Design and Analysis with Induction Generators, Second Edition provides detailed and accurate coverage of all aspects related to the design, operation, and overall analysis of such systems. Plac

  19. Computational Analysis of the SRS Phase III Salt Disposition Alternatives

    International Nuclear Information System (INIS)

    Completion of the Phase III evaluation and comparison of salt disposition alternatives was supported with enhanced computer models and analysis for each case on the ''short list'' of four options. SPEEDUP(TM) models and special purpose models describing mass and energy balances and flow rates were developed and used to predict performance and production characteristics for each of the options. Results from the computational analysis were a key part of the input used to select a primary and an alternate salt disposition alternative

  20. Advanced Post-Irradiation Examination Capabilities Alternatives Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Jeff Bryan; Bill Landman; Porter Hill

    2012-12-01

    An alternatives analysis was performed for the Advanced Post-Irradiation Capabilities (APIEC) project in accordance with the U.S. Department of Energy (DOE) Order DOE O 413.3B, “Program and Project Management for the Acquisition of Capital Assets”. The Alternatives Analysis considered six major alternatives: ? No Action ? Modify Existing DOE Facilities – capabilities distributed among multiple locations ? Modify Existing DOE Facilities – capabilities consolidated at a few locations ? Construct New Facility ? Commercial Partnership ? International Partnerships Based on the alternatives analysis documented herein, it is recommended to DOE that the advanced post-irradiation examination capabilities be provided by a new facility constructed at the Materials and Fuels Complex at the Idaho National Laboratory.

  1. Nonparametric Production Analysis under Alternative Price Conditions

    OpenAIRE

    Laurens Cherchye; Timo Kuosmanen; Thierry Post

    2001-01-01

    The literature on non-parametric production analysis has formulated tests for profit maximizing behavior that do not require a parametric specification of technology. Negative test results have conventionally been interpreted as inefficiency, or have been attributed to data perturbations. In this paper, we exploit the possibility that negative test results reveal violations of the underlying neoclassical assumption that prices are exogenously fixed and perfectly certain. We propose non-parame...

  2. Alternative comparison, analysis, and evaluation of solid waste and materials system alternatives

    International Nuclear Information System (INIS)

    This paper presents a comprehensive analysis of the impact of solid waste technical options on values and objectives that are important to the public. It is written in support of the Solid Waste and Materials Systems Alternatives Study (WHC, 1995). Described are the values that were identified, the major programmatic risks, how the impacts were measured, the performance of alternatives, the methodology used for the analysis, and the implications of the results. Decision analysis was used to guide the collection and analysis of data and the logic of the evaluation. Decision analysis is a structured process for the analysis and evaluation of alternatives. It is theoretically grounded in a set of axioms that capture the basic principles of decision making (von Neuman and Morgenstern 1947). Decision analysis objectively specifies what factors are to be considered, how they are to be measured and evaluated, and heir relative importance. The result is an analysis in which the underlying rationale or logic upon which the decision is based is made explicit. This makes possible open discussion of the decision basis in which facts and values are clearly distinguished, resulting in a well- documented decision that can be clearly explained and justified. The strategy of decision analysis is to analyze the various components relevant to the decision separately and then integrate the individual judgments to arrive at an overall decision. This assures that all the relevant factors are identified and their relative importance is considered. The procedure for obtaining the individual judgments, and the decision rules, for combining them and evaluating alternatives, have both theoretical and empirical foundation in mathematics, economics, and psychology

  3. Alternatives Analysis For Selecting ET 3 Site

    International Nuclear Information System (INIS)

    Engineered trenches (ETs) are considered to be a cost-effective method for disposing Low Level Waste (LLW). Based on waste forecasts from waste generators, the last engineered trench in operation (ET No.2) is anticipated to close in FY14, requiring development of a new ET. Solid Waste requested that SRNL develop an assessment report that reviews four disposal options for this new ET (ET No.3) and determine which option would provide the 'best' Performance Assessment (PA) disposal limits for LLW (Appendix A). Those four options (see option footprint locations in Figure 1-1) are: (1) Disposal at grade on TRU Pads 7-13 where soil would be mounded over waste packages; (2) Excavation at a slightly modified SLIT No.13 location - near the Used Equipment Storage Area; (3) Excavation at a modified SLIT No.12 location - near the 643-26E Naval Reactor Component Disposal Area; and (4) Excavation east of TRU Pad No.26 that replaces northeast portions of four slit trench (ST) disposal units in the eastern set of STs. The assessment consisted of both quantitative and qualitative analyses. The quantitative analysis captured key aspects that were readily quantifiable and had predictable impacts on limits and doses. A simplified modeling strategy stemming from current Special Analysis (SA) practices was employed. Both inventory capacity for a specific nuclide (a quasi-inventory limit) and overall performance for specified inventory mixtures (doses resulting from historical inventories) were considered. The qualitative analysis evaluated other key aspects based on engineering judgment in the form of pros and cons.

  4. Analysis of the Alternate Extrusion and Multiaxial Compression Process

    OpenAIRE

    Kwapisz M.; Knapiński M.; Dyja H.; Kawałek A.

    2015-01-01

    The paper present the results of numerical simulations of the alternate indirect extrusion and multiaxial compression process, performed using commercial software designed for the thermomechanical analysis of plastic working processes, Forge 2009. The novel method of alternate indirect extrusion and multiaxial compression, proposed by the authors, is characterized by the occurrence of strain states in the material being plastically worked, which are similar to those occurring in the equal cha...

  5. Analysis of the Alternate Extrusion and Multiaxial Compression Process

    Directory of Open Access Journals (Sweden)

    Kwapisz M.

    2015-04-01

    Full Text Available The paper present the results of numerical simulations of the alternate indirect extrusion and multiaxial compression process, performed using commercial software designed for the thermomechanical analysis of plastic working processes, Forge 2009. The novel method of alternate indirect extrusion and multiaxial compression, proposed by the authors, is characterized by the occurrence of strain states in the material being plastically worked, which are similar to those occurring in the equal channel angular pressing and cyclic extrusion compression processes.

  6. A review of recent NEPA alternatives analysis case law

    International Nuclear Information System (INIS)

    According to the Council on Environmental Quality (CEQ) Regulations for implementing the National Environmental Policy Act (NEPA), the analysis and comparison of alternatives is considered the 'heart' of the NEPA process. Although over 20 years have passed since the original mandate appeared to construct and assess a 'reasonable range' of alternatives contained in the CEQ Regulations, there is a perception that there is still a significant amount of confusion about what exactly constitutes a legally-compliant alternatives analysis. One manifestation of this confusion is the increasing amount of litigation over the alternatives analysis in NEPA documents. This study examined decisions on challenges to alternative analyses contained in federal agency NEPA documents in federal Courts of Appeals for the ten-year period 1996-2005. The results show that federal agencies are overwhelmingly successful against such challenges - winning 30 of the 37 cases. The most common challenge was that federal agencies had not included a full reasonable range of alternatives, while the second most frequent was that agencies had improperly constructed their purpose and need for their projects. Brief descriptions of several of the key court decisions are provided that illustrate the main factors that led to agencies being successful, as well as being unsuccessful, in their court challenges. The results provide little support for recent calls to amend the NEPA Statute and the CEQ Regulations to better clarify the requirements for alternatives analysis. The conclusion to the study focuses on practical steps NEPA practitioners can take to prepare their alternatives analyses in a manner that fulfills the requirements of the NEPA Statute and Council on Environmental Quality (CEQ) Regulations and makes them less vulnerable to an unfavorable court decision if legally challenged

  7. A semi-Markov reliability analysis of alternating systems

    International Nuclear Information System (INIS)

    Current nuclear power plants must be highly reliable with respect to safety and economy. Consequently, development of a new safety evaluation methodology is desired for the accurate evaluation of safety and economy. A nuclear power plant consists of many systems. This paper is concerned with the reliability evaluation of alternating systems. An alternating system usually consists of multitrains, and its operation alternates from one train to another. Examples of these are the nuclear service cooling water system, the component cooling water system, and the chemical and volume control system. The alternating systems exhibit strong dynamic time-dependent reliability characteristics because of the alternating operational mode and the technical specification requirements that are particularly difficult to analyze by static fault-tree techniques. The method used in this paper is based on the semi-Markov reliability analysis. The system performance measures evaluated are its contribution to the total risk of the plant (e.g., core damage probability) and to plant unavailability (reactor downtime). It is concluded that the methodology developed in this study can be applied to existing alternating systems for plant-specific evaluation of the various alternatives in technical specifications

  8. Cost-Benefit Analysis for Alternatives to Aliphatic Isocyanate Polyurethanes

    Science.gov (United States)

    Lewis, Pattie

    2007-01-01

    NASA and Air Force Space Command (AFSPC) have similar missions and therefore similar facilities and structures in similar environments. The standard practice for protecting metallic substrates in atmospheric environments is the application of an applied coating system. The most common topcoats used in coating systems are polyurethanes that contain isocyanates. Isocyanates are classified as potential human carcinogens and are known to cause cancer in animals. The primary objective of this effort was to demonstrate and validate alternatives to aliphatic isocyanate polyurethanes resulting in one or more isocyanate-free coatings qualified for use at AFSPC and NASA installations participating in this project. This Cost-Benefit Analysis (CBA) quantifies the estimated capital and process costs of coating alternatives and cost savings relative to the current coatings. The estimates in this CBA are to be used for assessing the relative merits of the selected alternatives. The actual economic effects at any specific facility will depend on the alternative material or technology implemented, the number of actual applications converted, future workloads, and other factors . The participants initially considered eighteen (18) alternative coatings as described in the Potential Alternatives Report entitled Potential Alternatives Report for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, prepared by ITB. Of those, 8 alternatives were selected for testing in accordance with the Joint Test Protocol entitled Joint Test Protocol for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, and the Field Test Plan entitled Field Evaluations Test Plan for Validation of Alternatives 10 Aliphatic Isocyanate Polyurethanes, both of which were prepared by ITB. A joint Test Report entitled Joint Test Report for Validation of Alternatives to Aliphatic Isocyanate Polyurethanes, prepared by ITB, documents the results of the laboratory and field testing, as well as any

  9. A Review of Nonparametric Alternatives to Analysis of Covariance.

    Science.gov (United States)

    Olejnik, Stephen F.; Algina, James

    1985-01-01

    Five distribution-free alternatives to parametric analysis of covariance are presented and demonstrated: Quade's distribution-free test, Puri and Sen's solution, McSweeney and Porter's rank transformation, Burnett and Barr's rank difference scores, and Shirley's general linear model solution. The results of simulation studies regarding Type I…

  10. Analysis of Alternative National Ambient Carbon Monoxide Standards

    OpenAIRE

    Ralph L. Keeney; Rakesh K. Sarin; Winkler, Robert L.

    1984-01-01

    A risk assessment model is developed to relate adverse health effects to alternative carbon monoxide standards. The analysis requires information in the form of available data and expert judgments concerning factors such as ambient CO level, human exposure to CO, physiological responses, and dose-response relationships. Quantitative estimates, including probabilities, are obtained for selected summary measures of adverse health effects.

  11. Decisions, Science, and Values: Crafting Regulatory Alternatives Analysis.

    Science.gov (United States)

    Malloy, Timothy; Blake, Ann; Linkov, Igor; Sinsheimer, Peter

    2015-12-01

    Emerging "prevention-based" approaches to chemical regulation seek to minimize the use of toxic chemicals by mandating or directly incentivizing the adoption of viable safer alternative chemicals or processes. California and Maine are beginning to implement such programs, requiring manufacturers of consumer products containing certain chemicals of concern to identify and evaluate potential safer alternatives. In the European Union, the REACH program imposes similar obligations on manufacturers of certain substances of very high concern. Effective prevention-based regulation requires regulatory alternatives analysis (RAA), a methodology for comparing and evaluating the regulated chemical or process and its alternatives across a range of relevant criteria. RAA has both public and private dimensions. To a significant degree, alternatives analysis is an aspect of product design; that is, the process by which private industry designs the goods it sells. Accordingly, an RAA method should reflect the attributes of well-crafted product design tools used by businesses. But RAA adds health and environmental objectives to the mix of concerns taken into account by the product designer. Moreover, as part of a prevention-based regulatory regime, it implicates important public values such as legitimacy, equity, public engagement, and accountability. Thus, an RAA should reflect both private standards and public values, and be evaluated against them. This article adopts that perspective, identifying an integrated set of design principles for RAA, and illustrating the application of those principles. PMID:26299695

  12. Comparative analysis of traditional and alternative energy sources

    International Nuclear Information System (INIS)

    The presented thesis with designation of Comparing analysis of traditional and alternative energy resources includes, on basis of theoretical information source, research in firm, internal data, trends in company development and market, description of the problem and its application. Theoretical information source is dedicated to the traditional and alternative energy resources, reserves of it, trends in using and development, the balance of it in the world, EU and in Slovakia as well. Analysis of the thesis is reflecting profile of the company and the thermal pump market evaluation using General Electric method. While the company is implementing, except other products, the thermal pumps on geothermal energy base and surround energy base (air), the mission of the comparing analysis is to compare traditional energy resources with thermal pump from the ecological, utility and economic side of it. The results of the comparing analysis are resumed in to the SWOT analysis. The part of the thesis includes t he questionnaire offer for effectiveness improvement and customer satisfaction analysis, and expected possibilities of alternative energy resources assistance (benefits) from the government and EU funds. (authors)

  13. 100-KE REACTOR CORE REMOVAL PROJECT ALTERNATIVE ANALYSIS WORKSHOP REPORT

    Energy Technology Data Exchange (ETDEWEB)

    HARRINGTON RA

    2010-01-15

    On December 15-16, 2009, a 100-KE Reactor Core Removal Project Alternative Analysis Workshop was conducted at the Washington State University Consolidated Information Center, Room 214. Colburn Kennedy, Project Director, CH2M HILL Plateau Remediation Company (CHPRC) requested the workshop and Richard Harrington provided facilitation. The purpose of the session was to select the preferred Bio Shield Alternative, for integration with the Thermal Shield and Core Removal and develop the path forward to proceed with project delivery. Prior to this workshop, the S.A. Robotics (SAR) Obstruction Removal Alternatives Analysis (565-DLV-062) report was issued, for use prior to and throughout the session, to all the team members. The multidisciplinary team consisted ofrepresentatives from 100-KE Project Management, Engineering, Radcon, Nuclear Safety, Fire Protection, Crane/Rigging, SAR Project Engineering, the Department of Energy Richland Field Office, Environmental Protection Agency, Washington State Department of Ecology, Defense Nuclear Facility Safety Board, and Deactivation and Decommission subject matter experts from corporate CH2M HILL and Lucas. Appendix D contains the workshop agenda, guidelines and expectations, opening remarks, and attendance roster going into followed throughout the workshop. The team was successful in selecting the preferred alternative and developing an eight-point path forward action plan to proceed with conceptual design. Conventional Demolition was selected as the preferred alternative over two other alternatives: Diamond Wire with Options, and Harmonic Delamination with Conventional Demolition. The teams preferred alternative aligned with the SAR Obstruction Removal Alternative Analysis report conclusion. However, the team identified several Path Forward actions, in Appendix A, which upon completion will solidify and potentially enhance the Conventional Demolition alternative with multiple options and approaches to achieve project delivery

  14. Alternative financial institutions? Sustainability, development, social reproduction, and gender analysis.

    Science.gov (United States)

    Kidder, T

    1999-08-01

    This paper proposes a conceptual framework for alternative financial institutions in Nicaragua. The article includes a discussion on innovative services and policies, which differentiate CARUNA (National Savings and Credit Cooperative ¿Caja Rural¿), and other financial institutions from conventional banks. It further examines theories that have altered the way development practitioners think about the economy, poverty reduction, and the positions of men and women in the society. These theories are the feminist economic theory and alternative development theories. Specific ways to incorporate the concepts of alternative and feminist economic theories in the design of financial institutions include open credit, savings, and remittance mechanisms, and coordinating councils. The gender analysis approach was used to evaluate the design of financial institutions. PMID:12349294

  15. Alternatives Generation Analysis Long Length Contaminated Equipment Removal System Storage

    International Nuclear Information System (INIS)

    Major pieces of Characterization sampling equipment are currently stored outdoors. This includes the Long Length Contaminated Equipment receiver trailer and transportation trailer. A decision is required to determine the preferred alternative for facilities to store and maintain this equipment. The Long Length Contaminated Equipment Removal System (LLCERS) consists of many tools, mechanisms, and controllers currently stored in various locations. Much of this equipment should be protected from the elements while being stored. Some of the LLCERS equipment should be protected with some kind of roof cover. This decision analysis is to determine the best alternative for weather protection for the large equipment requiring a cover. Additional details are included in Sections 2.0 and 5.0. Key assumptions used in this analysis are detailed in Section 3.2

  16. Complementary and alternative exercise for fibromyalgia: a meta-analysis

    OpenAIRE

    Mist SD; Firestone KA; Jones KD

    2013-01-01

    Scott David Mist, Kari Firestone, Kim Dupree Jones Fibromyalgia Research and Treatment Group, School of Nursing, Oregon Health and Science University, Portland, OR, USA Abstract: Complementary and alternative medicine includes a number of exercise modalities, such as tai chi, qigong, yoga, and a variety of lesser-known movement therapies. A meta-analysis of the current literature was conducted estimating the effect size of the different modalities, study quality and bias, and adverse events....

  17. Genome-wide analysis of alternative splicing in Chlamydomonas reinhardtii

    Directory of Open Access Journals (Sweden)

    Thomas Julie

    2010-02-01

    Full Text Available Abstract Background Genome-wide computational analysis of alternative splicing (AS in several flowering plants has revealed that pre-mRNAs from about 30% of genes undergo AS. Chlamydomonas, a simple unicellular green alga, is part of the lineage that includes land plants. However, it diverged from land plants about one billion years ago. Hence, it serves as a good model system to study alternative splicing in early photosynthetic eukaryotes, to obtain insights into the evolution of this process in plants, and to compare splicing in simple unicellular photosynthetic and non-photosynthetic eukaryotes. We performed a global analysis of alternative splicing in Chlamydomonas reinhardtii using its recently completed genome sequence and all available ESTs and cDNAs. Results Our analysis of AS using BLAT and a modified version of the Sircah tool revealed AS of 498 transcriptional units with 611 events, representing about 3% of the total number of genes. As in land plants, intron retention is the most prevalent form of AS. Retained introns and skipped exons tend to be shorter than their counterparts in constitutively spliced genes. The splice site signals in all types of AS events are weaker than those in constitutively spliced genes. Furthermore, in alternatively spliced genes, the prevalent splice form has a stronger splice site signal than the non-prevalent form. Analysis of constitutively spliced introns revealed an over-abundance of motifs with simple repetitive elements in comparison to introns involved in intron retention. In almost all cases, AS results in a truncated ORF, leading to a coding sequence that is around 50% shorter than the prevalent splice form. Using RT-PCR we verified AS of two genes and show that they produce more isoforms than indicated by EST data. All cDNA/EST alignments and splice graphs are provided in a website at http://combi.cs.colostate.edu/as/chlamy. Conclusions The extent of AS in Chlamydomonas that we observed is much

  18. Systematic analysis of alternative first exons in plant genomes

    Directory of Open Access Journals (Sweden)

    Zeng Changqing

    2007-10-01

    Full Text Available Abstract Background Alternative splicing (AS contributes significantly to protein diversity, by selectively using different combinations of exons of the same gene under certain circumstances. One particular type of AS is the use of alternative first exons (AFEs, which can have consequences far beyond the fine-tuning of protein functions. For example, AFEs may change the N-termini of proteins and thereby direct them to different cellular compartments. When alternative first exons are distant, they are usually associated with alternative promoters, thereby conferring an extra level of gene expression regulation. However, only few studies have examined the patterns of AFEs, and these analyses were mainly focused on mammalian genomes. Recent studies have shown that AFEs exist in the rice genome, and are regulated in a tissue-specific manner. Our current understanding of AFEs in plants is still limited, including important issues such as their regulation, contribution to protein diversity, and evolutionary conservation. Results We systematically identified 1,378 and 645 AFE-containing clusters in rice and Arabidopsis, respectively. From our data sets, we identified two types of AFEs according to their genomic organisation. In genes with type I AFEs, the first exons are mutually exclusive, while most of the downstream exons are shared among alternative transcripts. Conversely, in genes with type II AFEs, the first exon of one gene structure is an internal exon of an alternative gene structure. The functionality analysis indicated about half and ~19% of the AFEs in Arabidopsis and rice could alter N-terminal protein sequences, and ~5% of the functional alteration in type II AFEs involved protein domain addition/deletion in both genomes. Expression analysis indicated that 20~66% of rice AFE clusters were tissue- and/or development- specifically transcribed, which is consistent with previous observations; however, a much smaller percentage of Arabidopsis

  19. Elk Valley Rancheria Energy Efficiency and Alternatives Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ed Wait, Elk Valley Rancheria; Frank Ziano & Associates, Inc.

    2011-11-30

    Elk Valley Rancheria; Tribe; renewable energy; energy options analysis. The Elk Valley Rancheria, California ('Tribe') is a federally recognized Indian tribe located in Del Norte County, California, in the northwestern corner of California. The Tribe, its members and Tribal enterprises are challenged by increasing energy costs and undeveloped local energy resources. The Tribe currently lacks an energy program. The Tribal government lacked sufficient information to make informed decisions about potential renewable energy resources, energy alternatives and other energy management issues. To meet this challenge efficiently, the Tribe contracted with Frank Zaino and Associates, Inc. to help become more energy self-sufficient, by reducing their energy costs and promoting energy alternatives that stimulate economic development. Frank Zaino & Associates, Inc. provided a high level economic screening analysis based on anticipated electric and natural gas rates. This was in an effort to determine which alternative energy system will performed at a higher level so the Tribe could reduce their energy model by 30% from alternative fuel sources. The feasibility study will identify suitable energy alternatives and conservation methods that will benefit the Tribe and tribal community through important reductions in cost. The lessons learned from these conservation efforts will yield knowledge that will serve a wider goal of executing energy efficiency measures and practices in Tribal residences and business facilities. Pacific Power is the provider of electrical power to the four properties under review at $ 0.08 per Kilowatt-hour (KWH). This is a very low energy cost compared to alternative energy sources. The Tribe used baseline audits to assess current and historic energy usage at four Rancheria owned facilities. Past electric and gas billing statements were retained for review for the four buildings that will be audited. A comparative assessment of the various

  20. Low-Level Waste Disposal Alternatives Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Timothy Carlson; Kay Adler-Flitton; Roy Grant; Joan Connolly; Peggy Hinman; Charles Marcinkiewicz

    2006-09-01

    This report identifies and compares on-site and off-site disposal options for the disposal of contract-handled and remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Potential disposal options are screened for viability by waste type resulting in a short list of options for further consideration. The most crediable option are selected after systematic consideration of cost, schedule constraints, and risk. In order to holistically address the approach for low-level waste disposal, options are compiled into comprehensive disposal schemes, that is, alternative scenarios. Each alternative scenario addresses the disposal path for all low-level waste types over the period of interest. The alternative scenarios are compared and ranked using cost, risk and complexity to arrive at the recommended approach. Schedule alignment with disposal needs is addressed to ensure that all waste types are managed appropriately. The recommended alternative scenario for the disposal of low-level waste based on this analysis is to build a disposal facility at the Idaho National Laboratory Site.

  1. Low-Level Waste Disposal Alternatives Analysis Report

    International Nuclear Information System (INIS)

    This report identifies and compares on-site and off-site disposal options for the disposal of contract-handled and remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Potential disposal options are screened for viability by waste type resulting in a short list of options for further consideration. The most credible option are selected after systematic consideration of cost, schedule constraints, and risk. In order to holistically address the approach for low-level waste disposal, options are compiled into comprehensive disposal schemes, that is, alternative scenarios. Each alternative scenario addresses the disposal path for all low-level waste types over the period of interest. The alternative scenarios are compared and ranked using cost, risk and complexity to arrive at the recommended approach. Schedule alignment with disposal needs is addressed to ensure that all waste types are managed appropriately. The recommended alternative scenario for the disposal of low-level waste based on this analysis is to build a disposal facility at the Idaho National Laboratory Site

  2. Latent common manifold learning with alternating diffusion: analysis and applications

    CERN Document Server

    Talmon, Ronen

    2016-01-01

    The analysis of data sets arising from multiple sensors has drawn significant research attention over the years. Traditional methods, including kernel-based methods, are typically incapable of capturing nonlinear geometric structures. We introduce a latent common manifold model underlying multiple sensor observations for the purpose of multimodal data fusion. A method based on alternating diffusion is presented and analyzed; we provide theoretical analysis of the method under the latent common manifold model. To exemplify the power of the proposed framework, experimental results in several applications are reported.

  3. Complementary and alternative exercise for fibromyalgia: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Mist SD

    2013-03-01

    Full Text Available Scott David Mist, Kari Firestone, Kim Dupree Jones Fibromyalgia Research and Treatment Group, School of Nursing, Oregon Health and Science University, Portland, OR, USA Abstract: Complementary and alternative medicine includes a number of exercise modalities, such as tai chi, qigong, yoga, and a variety of lesser-known movement therapies. A meta-analysis of the current literature was conducted estimating the effect size of the different modalities, study quality and bias, and adverse events. The level of research has been moderately weak to date, but most studies report a medium-to-high effect size in pain reduction. Given the lack of adverse events, there is little risk in recommending these modalities as a critical component in a multimodal treatment plan, which is often required for fibromyalgia management. Keywords: fibromyalgia, exercise, complementary and alternative, efficacy, safety

  4. Tradeoff Analysis for Combat Service Support Wireless Communications Alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Burnette, John R.; Thibodeau, Christopher C.; Greitzer, Frank L.

    2002-02-28

    As the Army moves toward more mobile and agile forces and continued sustainment of numerous high-cost legacy logistics management systems, the requirement for wireless connectivity and a wireless network to supporting organizations has become ever more critical. There are currently several Army communications initiatives underway to resolve this wireless connectivity issue. However, to fully appreciate and understand the value of these initiatives, a Tradeoff Analysis is needed. The present study seeks to identify and assess solutions. The analysis identified issues that impede Interim Brigade Combat Team (IBCT) communication system integration and outlined core requirements for sharing of logistics data between the field and Army battle command systems. Then, the analysis examined wireless communication alternatives as possible solutions for IBCT logistics communications problems. The current baseline system was compared with possible alternatives involving tactical radio systems, wireless/near term digital radio, cellular satellite, and third-generation (3G) wireless technologies. Cellular satellite and 3G wireless technologies offer clear advantages and should be considered for later IBCTs.

  5. Analysis of alternatives for immobilized low-activity waste disposal

    International Nuclear Information System (INIS)

    This report presents a study of alternative disposal system architectures and implementation strategies to provide onsite near-surface disposal capacity to receive the immobilized low-activity waste produced by the private vendors. The analysis shows that a flexible unit strategy that provides a suite of design solutions tailored to the characteristics of the immobilized low-activity waste will provide a disposal system that best meets the program goals of reducing the environmental, health, and safety impacts; meeting the schedule milestones; and minimizing the life-cycle cost of the program

  6. Conflict analysis and management alternative for the Manayunk Canal

    International Nuclear Information System (INIS)

    The solution of a water resource allocation problem by an alternative social arrangement is presented. Classical Austrian economic theory and the new resources economics provide both theoretical and practical evidence to support the development of well-defined, private property rights to the water resource in question. A conflict analysis demonstrates that management of the Manayunk Canal by a firm would reconcile existing confrontations through compromise use of the water resource. Benefit and cost calculations show that a compromise among industrial and recreational interests, currently competing in the political arena, would increase social benefits

  7. Analysis of alternatives for immobilized low activity waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Burbank, D.A.

    1997-10-28

    This report presents a study of alternative disposal system architectures and implementation strategies to provide onsite near-surface disposal capacity to receive the immobilized low-activity waste produced by the private vendors. The analysis shows that a flexible unit strategy that provides a suite of design solutions tailored to the characteristics of the immobilized low-activity waste will provide a disposal system that best meets the program goals of reducing the environmental, health, and safety impacts; meeting the schedule milestones; and minimizing the life-cycle cost of the program.

  8. Stability analysis of abandoned drift for alternative utilization

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo-Hyun; Yoo, In-Kol; Kim, Moon-Seob; Kim, Ryang-Hee [Korea Resources Corp., Seoul(Korea); Yang, Hyung-Sik [Chonnam National University, Kwangju(Korea); Lee, Hi-Keun [Seoul National University, Seoul(Korea); Kim, Jae-Dong [Kangwon National University, Chuncheon(Korea)

    2000-04-30

    This study was performed to find the way that is alternative utilization of the drift that had been abandoned by coal industry promotion. To determine whether abandoned drift would be maintained without supports or not, the safety inspection that consists of drift survey, laboratory tests, rock mass classification and numerical analysis was performed. According to the result, there were discontinuity sets those had unfavorable orientation to the drift and rock mass around the drift had generally poor condition. So, it would be much difficult that abandoned drift is maintained without supports. (author). 15 refs., 8 tabs., 7 figs.

  9. Technology Development on Alternate Source Term Analysis and Application

    International Nuclear Information System (INIS)

    Source term presented in TID-14844 and Regulatory Guide 1.4 has been used to estimate radiation dose from design basis accidents. However, a more realistic and physically-based source term, alternate source term, has been developed and presented in NUREG-1465 and Regulatory Guide 1.183. In addition, the concept and criteria of radiological dose estimation has been changed through the serial publications of ICRP-9, 26, and 60. In ICRP-60, ICRP introduced effective dose concept in stead of dose concept based on critical organ and whole body since the publication of ICRP-9. Korean regulatory authority is planning to issue the new regulation to adopt the alternate source term and the effective dose concept to radiation dose analysis for design basis accidents. As a measure for the issuance of the new regulation, the application methodology of alternate source term and effective dose for design basis accidents was established and merged to the computer program called DBADOSE. This program was verified in accordance with the verification procedure. The result of calculation by DBADOSE showed small difference of less than 5% in comparison with the result of STARDOSE which was developed by Polestar Applied Technology, Inc. Kori Units 3,4 was selected as a pilot plant to apply the alternate source term and the effective dose. The margins to licensing criteria were reanalyzed for design basis accidents. As a result of this application, it was assured that current design of Kori Units 3,4 has enough margins and design simplification were proposed. (authors)

  10. Life-cycle analysis of alternative aviation fuels in GREET

    Energy Technology Data Exchange (ETDEWEB)

    Elgowainy, A.; Han, J.; Wang, M.; Carter, N.; Stratton, R.; Hileman, J.; Malwitz, A.; Balasubramanian, S. (Energy Systems)

    2012-07-23

    The Greenhouse gases, Regulated Emissions, and Energy use in Transportation (GREET) model, developed at Argonne National Laboratory, has been expanded to include well-to-wake (WTWa) analysis of aviation fuels and aircraft. This report documents the key WTWa stages and assumptions for fuels that represent alternatives to petroleum jet fuel. The aviation module in GREET consists of three spreadsheets that present detailed characterizations of well-to-pump and pump-to-wake parameters and WTWa results. By using the expanded GREET version (GREET1{_}2011), we estimate WTWa results for energy use (total, fossil, and petroleum energy) and greenhouse gas (GHG) emissions (carbon dioxide, methane, and nitrous oxide) for (1) each unit of energy (lower heating value) consumed by the aircraft or (2) each unit of distance traveled/ payload carried by the aircraft. The fuel pathways considered in this analysis include petroleum-based jet fuel from conventional and unconventional sources (i.e., oil sands); Fisher-Tropsch (FT) jet fuel from natural gas, coal, and biomass; bio-jet fuel from fast pyrolysis of cellulosic biomass; and bio-jet fuel from vegetable and algal oils, which falls under the American Society for Testing and Materials category of hydroprocessed esters and fatty acids. For aircraft operation, we considered six passenger aircraft classes and four freight aircraft classes in this analysis. Our analysis revealed that, depending on the feedstock source, the fuel conversion technology, and the allocation or displacement credit methodology applied to co-products, alternative bio-jet fuel pathways have the potential to reduce life-cycle GHG emissions by 55-85 percent compared with conventional (petroleum-based) jet fuel. Although producing FT jet fuel from fossil feedstock sources - such as natural gas and coal - could greatly reduce dependence on crude oil, production from such sources (especially coal) produces greater WTWa GHG emissions compared with petroleum jet

  11. Life-Cycle Analysis of Alternative Aviation Fuels in GREET

    Energy Technology Data Exchange (ETDEWEB)

    Elgowainy, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Han, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Wang, M. [Argonne National Lab. (ANL), Argonne, IL (United States); Carter, N. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Stratton, R. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Hileman, J. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Malwitz, A. [Volpe National Transportation Systems Center, Cambridge, MA (United States); Balasubramanian, S. [Volpe National Transportation Systems Center, Cambridge, MA (United States)

    2012-06-01

    The Greenhouse gases, Regulated Emissions, and Energy use in Transportation (GREET) model, developed at Argonne National Laboratory, has been expanded to include well-to-wake (WTWa) analysis of aviation fuels and aircraft. This report documents the key WTWa stages and assumptions for fuels that represent alternatives to petroleum jet fuel. The aviation module in GREET consists of three spreadsheets that present detailed characterizations of well-to-pump and pump-to-wake parameters and WTWa results. By using the expanded GREET version (GREET1_2011), we estimate WTWa results for energy use (total, fossil, and petroleum energy) and greenhouse gas (GHG) emissions (carbon dioxide, methane, and nitrous oxide) for (1) each unit of energy (lower heating value) consumed by the aircraft or(2) each unit of distance traveled/ payload carried by the aircraft. The fuel pathways considered in this analysis include petroleum-based jet fuel from conventional and unconventional sources (i.e., oil sands); Fisher-Tropsch (FT) jet fuel from natural gas, coal, and biomass; bio-jet fuel from fast pyrolysis of cellulosic biomass; and bio-jet fuel from vegetable and algal oils, which falls under the American Society for Testing and Materials category of hydroprocessed esters and fatty acids. For aircraft operation, we considered six passenger aircraft classes and four freight aircraft classes in this analysis. Our analysis revealed that, depending on the feedstock source, the fuel conversion technology, and the allocation or displacement credit methodology applied to co-products, alternative bio-jet fuel pathways have the potential to reduce life-cycle GHG emissions by 55–85 percent compared with conventional (petroleum-based) jet fuel. Although producing FT jet fuel from fossil feedstock sources — such as natural gas and coal — could greatly reduce dependence on crude oil, production from such sources (especially coal) produces greater WTWa GHG emissions compared with petroleum jet

  12. Pathway analysis for alternate low-level waste disposal methods

    International Nuclear Information System (INIS)

    The purpose of this paper is to evaluate a complete set of environmental pathways for disposal options and conditions that the Nuclear Regulatory Commission (NRC) may analyze for a low-level radioactive waste (LLW) license application. The regulations pertaining In the past, shallow-land burial has been used for the disposal of low-level radioactive waste. However, with the advent of the State Compact system of LLW disposal, many alternative technologies may be used. The alternative LLW disposal facilities include below- ground vault, tumulus, above-ground vault, shaft, and mine disposal This paper will form the foundation of an update of the previously developed Sandia National Laboratories (SNL)/NRC LLW performance assessment methodology. Based on the pathway assessment for alternative disposal methods, a determination will be made about whether the current methodology can satisfactorily analyze the pathways and phenomena likely to be important for the full range of potential disposal options. We have attempted to be conservative in keeping pathways in the lists that may usually be of marginal importance. In this way we can build confidence that we have spanned the range of cases likely to be encountered at a real site. Results of the pathway assessment indicate that disposal methods can be categorized in groupings based on their depth of disposal. For the deep disposal options of shaft and mine disposal, the key pathways are identical. The shallow disposal options, such as tumulus, shallow-land, and below-ground vault disposal also may be grouped together from a pathway analysis perspective. Above-ground vault disposal cannot be grouped with any of the other disposal options. The pathway analysis shows a definite trend concerning depth of disposal. The above-ground option has the largest number of significant pathways. As the waste becomes more isolated, the number of significant pathways is reduced. Similar to shallow-land burial, it was found that for all

  13. Analysis of alternative light water reactor (LWR) fuel cycles

    International Nuclear Information System (INIS)

    Nine alternative LWR fuel cycles are analyzed in terms of the isotopic content of the fuel material, the relative amounts of primary and recycled material, the uranium and thorium requirements, the fuel cycle costs and the fraction of energy which must be generated at secured sites. The fuel materials include low-enriched uranium (LEU), plutonium-uranium (MOX), highly-enriched uranium-thorium (HEU-Th), denatured uranium-thorium (DU-Th) and plutonium-thorium (Pu-Th). The analysis is based on tracing the material requirements of a generic pressurized water reactor (PWR) for a 30-year period at constant annual energy output. During this time period all the created fissile material is recycled unless its reactivity worth is less than 0.2% uranium enrichment plant tails

  14. Nutrient analysis of the Beef Alternative Merchandising cuts.

    Science.gov (United States)

    Desimone, T L; Acheson, R A; Woerner, D R; Engle, T E; Douglass, L W; Belk, K E

    2013-03-01

    The objective of this study was to generate raw and cooked nutrient composition data to identify Quality Grade differences in proximate values for eight Beef Alternative Merchandising (BAM) cuts. The data generated will be used to update the nutrient data in the USDA National Nutrient Database for Standard Reference (SR). Beef Rib, Oven-Prepared, Beef Loin, Strip Loin, and Beef Loin, Top Sirloin Butt subprimals were collected from a total of 24 carcasses from four packing plants. The carcasses were a combination of USDA Yield Grades 2 (n=12) and 3 (n=12), USDA Quality Grades upper two-thirds Choice (n=8), low Choice (n=8), and Select (n=8), and two genders, steer (n=16) and heifer (n=8). After aging, subprimals were fabricated into the BAM cuts, dissected, and nutrient analysis was performed. Sample homogenates from each animal were homogenized and composited for analysis of the following: proximate analysis, long chain and trans-fatty acids, conjugated linoleic acid, total cholesterol, vitamin B-12, and selenium. This study identified seven BAM cuts from all three Quality Grades that qualify for USDA Lean; seven Select cuts that qualify for USDA Extra Lean; and three Select cuts that qualify for the American Heart Association's Heart Healthy Check. PMID:23261533

  15. An Analysis of State Policies Connected with Alternative School Programs

    Science.gov (United States)

    Bielefeld, William C.; Stubblefield, Anna; Templeton, Zach

    2009-01-01

    Many school districts offer alternative education programs for their students who do not succeed in the regular classroom. At the high school level, many of these programs are separated from the regular schools. It seemed that many districts were establishing alternative education programs, but there were differences in the types of programs that…

  16. Ipsative measurement and the analysis of organizational values: an alternative approach for data analysis

    NARCIS (Netherlands)

    F.M. van Eijnatten; L.A. van der Ark; S.S. Holloway

    2015-01-01

    In this paper, the analysis and test of ipsative data will be discussed, and some alternative methods will be suggested. Following a review of the literature about ipsative measurement, the Competing Values Framework will be presented as a major application in the field of organizational culture and

  17. Remote-Handled Low Level Waste Disposal Project Alternatives Analysis

    Energy Technology Data Exchange (ETDEWEB)

    David Duncan

    2010-10-01

    This report identifies, evaluates, and compares alternatives for meeting the U.S. Department of Energy’s mission need for management of remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Each alternative identified in the Mission Need Statement for the Remote-Handled Low-Level Waste Treatment Project is described and evaluated for capability to fulfill the mission need. Alternatives that could meet the mission need are further evaluated and compared using criteria of cost, risk, complexity, stakeholder values, and regulatory compliance. The alternative for disposal of remote-handled low-level waste that has the highest confidence of meeting the mission need and represents best value to the government is to build a new disposal facility at the Idaho National Laboratory Site.

  18. Long-term-consequence analysis of no action alternative 2

    Energy Technology Data Exchange (ETDEWEB)

    Buck, J.W.; Bagaasen, L.M.; Staven, L.H.; Serne, R.J. [and others

    1996-07-01

    This report is a supplement to the Waste Isolation Pilot Plant (WIPP) Disposal-Phase Supplemental Environmental Impact Statement. Data and information is described which pertains to estimated impacts from postulated long-term release of radionuclides and hazardous constituents from alpha-bearing wastes stored at major generator/storage sites after loss of institutional control (no action alternative 2). Under this alternative, wastes would remain at the generator sites and not be emplaced at WIPP.

  19. Long-term-consequence analysis of no action alternative 2

    International Nuclear Information System (INIS)

    This report is a supplement to the Waste Isolation Pilot Plant (WIPP) Disposal-Phase Supplemental Environmental Impact Statement. Data and information is described which pertains to estimated impacts from postulated long-term release of radionuclides and hazardous constituents from alpha-bearing wastes stored at major generator/storage sites after loss of institutional control (no action alternative 2). Under this alternative, wastes would remain at the generator sites and not be emplaced at WIPP

  20. A component analysis of "stereotypy as reinforcement" for alternative behavior.

    OpenAIRE

    Hanley, G P; Iwata, B A; Thompson, R H; Lindberg, J S

    2000-01-01

    Results from several studies have suggested that the opportunity to engage in stereotypic behavior may function as reinforcement for alternative, more socially desirable behaviors. However, the procedural components of this intervention include several distinct operations whose effects have not been analyzed separately. While measuring the occurrence of stereotypy and an alternative behavior (manipulation of leisure materials), we exposed 3 participants to three or four components of a "stere...

  1. Alternatives generation and analysis for phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Britton, M.D.

    1996-10-02

    This document provides; a decision analysis summary; problem statement; constraints, requirements, and assumptions; decision criteria; intermediate waste feed staging system options and alternatives generation and screening; intermediate waste feed staging system design concepts; intermediate waste feed staging system alternative evaluation and analysis; and open issues and actions.

  2. Cost-Benefit Analysis For Alternative Low-Emission Surface Preparation/ Depainting Technologies for Structural Steel

    Science.gov (United States)

    Lewis, Pattie

    2007-01-01

    Stennis Space Center (SSC), Kennedy Space Center (KSC) and Air Force Space Command (AFSPC) identified particulate emissions and waste generated from the depainting process of steel structures as hazardous materials to be eliminated or reduced. A Potential Alternatives Report, Potential Alternatives Report for Validation of Alternative Low Emission Surface Preparation/Depainting Technologies for Structural Steel, provided a technical analyses of identified alternatives to the current coating removal processes, criteria used to select alternatives for further analysis, and a list of those alternatives recommended for testing. The initial coating removal alternatives list was compiled using literature searches and stakeholder recommendations. The involved project participants initially considered approximately 13 alternatives. In late 2003, core project members selected the following depainting processes to be further evaluated: (1) Plastic Blast Media-Quickstrip(R)-A. (2) Hard Abrasive-Steel-Magic(R). (3) Sponge Blasting-Sponge-Jet(R). (4) Liquid Nitrogen-NItroJet(R). (5) Mechanical Removal with Vacuum Attachment-DESCO and OCM Clean-Air (6) Laser Coating Removal Alternatives were tested in accordance with the Joint Test Protocol for Validation of Alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel, and the Field Evaluation Test Plan for Validation of Alternative Low-Emission Surface Preparation/Depainting Technologies for Structural Steel. Results of the testing are documented in the Joint Test Report. This Cost-Benefit Analysis (CBA) focuses on the three alternatives (Quickstrip(R)-A, SteelMagic (R), and Sponge-Jet(R)) that were considered viable alternatives for large area operations based on the results of the field demonstration and lab testing. This CBA was created to help participants determine if implementation of the candidate alternatives is economically justified. Each of the alternatives examined reduced Environmental

  3. Alternative Nonvolatile Residue Analysis with Contaminant Identification Project

    Science.gov (United States)

    Loftin, Kathleen (Compiler); Summerfield, Burton (Compiler); Thompson, Karen (Compiler); Mullenix, Pamela (Compiler); Zeitlin, Nancy (Compiler)

    2015-01-01

    Cleanliness verification is required in numerous industries including spaceflight ground support, electronics, medical and aerospace. Currently at KSC requirement for cleanliness verification use solvents that environmentally unfriendly. This goal of this project is to produce an alternative cleanliness verification technique that is both environmentally friendly and more cost effective.

  4. An alternative method for performing pressurized thermal shock analysis

    International Nuclear Information System (INIS)

    This paper describes how Probability of Crack Initiation and acceptable Pressurized Thermal Shock frequency were correlated with ac and summarizes several example applications, including evaluation of potential plant modifications. Plans for an industry supported pilot-plant application of the alternative Probabilistic Fracture Mechanics method for RG 1.154 are also discussed. 9 refs, 4 figs, 1 tab

  5. 40 CFR 68.28 - Alternative release scenario analysis.

    Science.gov (United States)

    2010-07-01

    .... 68.28 Section 68.28 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... alternative release scenarios: (1) The five-year accident history provided in § 68.42; and (2) Failure... applicable as part of current practices. Proprietary models that account for the modeling conditions may...

  6. Alternatives to Multilevel Modeling for the Analysis of Clustered Data

    Science.gov (United States)

    Huang, Francis L.

    2016-01-01

    Multilevel modeling has grown in use over the years as a way to deal with the nonindependent nature of observations found in clustered data. However, other alternatives to multilevel modeling are available that can account for observations nested within clusters, including the use of Taylor series linearization for variance estimation, the design…

  7. Cost analysis of Navy acquisition alternatives for the NAVSTAR Global Positioning System

    Science.gov (United States)

    Darcy, T. F.; Smith, G. P.

    1982-12-01

    This research analyzes the life cycle cost (LCC) of the Navy's current and two hypothetical procurement alternatives for NAVSTAR Global Positioning System (GPS) user equipment. Costs are derived by the ARINC Research Corporation ACBEN cost estimating system. Data presentation is in a comparative format describing individual alternative LCC and differential costs between alternatives. Sensitivity analysis explores the impact receiver-processor unit (RPU) first unit production cost has on individual alternative LCC, as well as cost differentials between each alternative. Several benefits are discussed that might provide sufficient cost savings and/or system effectiveness improvements to warrant a procurement strategy other than the existing proposal.

  8. Energy demand analysis in the workshop on alternative energy strategies

    Energy Technology Data Exchange (ETDEWEB)

    Carhart, S C

    1978-04-01

    The Workshop on Alternative Energy Strategies, conducted from 1974 through 1977, was an international study group formed to develop consistent national energy alternatives within a common analytical framework and global assumptions. A major component of this activity was the demand program, which involved preparation of highly disaggregated demand estimates based upon estimates of energy-consuming activities and energy requirements per unit of activity reported on a consistent basis for North America, Europe, and Japan. Comparison of the results of these studies reveals that North America requires more energy per unit of activity in many consumption categories, that major improvements in efficiency will move North America close to current European and Japanese efficiencies, and that further improvements in European and Japanese efficiencies may be anticipated as well. When contrasted with expected availabilities of fuels, major shortfalls of oil relative to projected demands emerge in the eighties and nineties. Some approaches to investment in efficiency improvements which will offset these difficulties are discussed.

  9. Neutronic analysis of alternative structural materials for fusion reactor blankets

    International Nuclear Information System (INIS)

    The neutronic performance of the International Tokamak Reactor (INTOR) blanket was studied when several alternative structural materials were used instead of the INTOR reference structural material, type 316 stainless steel. The alternative structural materials included: ferritic-, vanadium-, titanium-, long range ordered-, manganese austenitic-, and nimonic-alloys. All were treated both with and without a first-wall coating of beryllium or graphite. The tritium breeding ratio, the nuclear heating, and the gas (hydrogen and helium) production rates in the structural materials were calclated for the possible combinations of structural material and first-wall coating. These parameters were compared with those obtained by using SS-316. The nimonic alloy was the only one with worse neutronic performance than the SS-316. (orig.)

  10. Economic Environmental Valuation: An Analysis of Limitations and Alternatives.

    OpenAIRE

    Paul Knights, Jeroen Admiraal, Ada Wossink, Prasenjit Banerjee, John O’Neill and Michael Scott

    2013-01-01

    The structure of this report is as follows. In Section 2 we introduce economic methods for environmental and biodiversity valuation, and in particular the total economic value model. Sections 3 through 7 will advance five distinct but related classes of criticisms of economic environmental valuation, and in each we will suggest the way in which alternative valuation methods contain the resources to help address those criticisms.

  11. Peptide-Centric Proteome Analysis: An Alternative Strategy for the Analysis of Tandem Mass Spectrometry Data

    Energy Technology Data Exchange (ETDEWEB)

    Ting, Ying S.; Egertson, Jarrett D.; Payne, Samuel H.; Kim, Sangtae; MacLean, Brendan; Kall, Lukas; Aebersold, Ruedi; Smith, Richard D.; Noble, William; MacCoss, Michael

    2015-09-01

    In mass spectrometry-based bottom-up proteomics, data-independent acquisition (DIA) is an emerging technique due to its comprehensive and unbiased sampling of precursor ions. However, current DIA methods use wide precursor isolation windows, resulting in co- fragmentation and complex mixture spectra. Thus, conventional database searching tools that identify peptides by interpreting individual MS/MS spectra are inherently limited in analyzing DIA data. Here we discuss an alternative approach, peptide-centric analysis, which tests directly for the presence and absence of query peptides. We discuss how peptide-centric analysis resolves some limitations of traditional spectrum-centric analysis, and we outline the benefits of peptide-centric analysis in general.

  12. Verbal rating of alternative research reactors using fuzzy decision analysis

    International Nuclear Information System (INIS)

    An approach is introduced here for making decisions about alternative research reactor types based on their compatibility with the environment of Saudi Arabia and is applied to the choice between pool, light water tank, heavy water tank, and TRIGA reactors. The method is based on the fuzzy decision theory, and it allows for consideration of the availability of required local resources as well as ease of acquisition of imported resources, community acceptance, and future expandability. The use of fuzzy decision theory can overcome the numerical precision of a decision maker's judgment by allowing verbal rating and weighting for each attribute and subattribute

  13. 75 FR 30100 - FY 2010 Discretionary Livability Funding Opportunity: Alternatives Analysis Program

    Science.gov (United States)

    2010-05-28

    ... of a wide range of public transportation alternatives designed to address a transportation problem in... substantial transportation problem in the study corridor and the degree to which the Alternatives Analysis..., Transportation Problems, and Needs. Applicants should provide a statement of the transportation problem for...

  14. Alternatives Generation and Analysis for Phase 1 High-Level Waste Feed Tanks Selection

    International Nuclear Information System (INIS)

    A recent revision of the US Department of Energy privatization contract for the immobilization of high-level waste (HLW) at Hanford necessitates the investigation of alternative waste feed sources to meet contractual feed requirements. This analysis identifies wastes to be considered as HLW feeds and develops and conducts alternative analyses to comply with established criteria. A total of 12,426 cases involving 72 waste streams are evaluated and ranked in three cost-based alternative models. Additional programmatic criteria are assessed against leading alternative options to yield an optimum blended waste feed stream

  15. Summary of Plutonium-238 Production Alternatives Analysis Final Report

    Energy Technology Data Exchange (ETDEWEB)

    James Werner; Wade E. Bickford; David B. Lord; Chadwick D. Barklay

    2013-03-01

    The Team implemented a two-phase evaluation process. During the first phase, a wide variety of past and new candidate facilities and processing methods were assessed against the criteria established by DOE for this assessment. Any system or system element selected for consideration as an alternative within the project to reestablish domestic production of Pu-238 must meet the following minimum criteria: Any required source material must be readily available in the United States, without requiring the development of reprocessing technologies or investments in systems to separate material from identified sources. It must be cost, schedule, and risk competitive with existing baseline technology. Any identified facilities required to support the concept must be available to the program for the entire project life cycle (notionally 35 years, unless the concept is so novel as to require a shorter duration). It must present a solution that can generate at least 1.5 Kg of Pu-238 oxide per year, for at least 35 years. It must present a low-risk, near-term solution to the National Aeronautics and Space Administration’s urgent mission need. DOE has implemented this requirement by eliminating from project consideration any alternative with key technologies at less than Technology Readiness Level 5. The Team evaluated the options meeting these criteria using a more detailed assessment of the reasonable facility variations and compared them to the preferred option, which consists of target irradiation at the Advanced Test Reactor (ATR) and the High Flux Isotope Reactor (HFIR), target fabrication and chemical separations processing at the ORNL Radiochemical Engineering Development Center, and neptunium 237 storage at the Materials and Fuels Complex at INL. This preferred option is consistent with the Records of Decision from the earlier National Environmental Policy Act (NEPA) documentation

  16. Efficiency analysis of alternative refrigerants for ejector cooling cycles

    International Nuclear Information System (INIS)

    Highlights: • Advantages of using alternative refrigerants as ejector refrigerants were presumed. • Computer software basing on theoretical model of Huang et al. (1999) was prepared. • Optimal temperature range of primary vapor for each working fluid was calculated. - Abstract: Computer software, basing on the theoretical model of Huang et al. with thermodynamic properties of selected refrigerants, was prepared. Investigation was focused on alternative refrigerants that belong to two groups of substances: common solvents (acetone, benzene, cyclopentane, cyclohexane and toluene) and non-flammable synthetic refrigerants applied in Organic Rankine Cycle (ORC) (R236ea, R236fa, R245ca, R245fa, R365mfc and RC318). Refrigerants were selected to detect a possibility to use them in ejector cooling system powered by a high-temperature heat source. A series of calculations were carried out for the generator temperature between 70 and 200 °C, with assumed temperatures of evaporation 10 °C and condensation 40 °C. Investigation revealed that there is no single refrigerant that ensures efficient operation of the system in the investigated temperature range of primary vapor. Each substance has its own maximum entrainment ratio and COP at its individual temperature of the optimum. The use of non-flammable synthetic refrigerants allows obtaining higher COP in the low primary vapor temperature range. R236fa was the most beneficial among the non-flammable synthetic refrigerants tested. The use of organic solvents can be justified only for high values of motive steam temperature. Among the solvents, the highest values of entrainment ratio and COP throughout the range of motive temperature were noted for cyclopentane. Toluene was found to be an unattractive refrigerant from the ejector cooling point of view

  17. Analysis of generalized Schwarz alternating procedure for domain decomposition

    Energy Technology Data Exchange (ETDEWEB)

    Engquist, B.; Zhao, Hongkai [Univ. of California, Los Angeles, CA (United States)

    1996-12-31

    The Schwartz alternating method(SAM) is the theoretical basis for domain decomposition which itself is a powerful tool both for parallel computation and for computing in complicated domains. The convergence rate of the classical SAM is very sensitive to the overlapping size between each subdomain, which is not desirable for most applications. We propose a generalized SAM procedure which is an extension of the modified SAM proposed by P.-L. Lions. Instead of using only Dirichlet data at the artificial boundary between subdomains, we take a convex combination of u and {partial_derivative}u/{partial_derivative}n, i.e. {partial_derivative}u/{partial_derivative}n + {Lambda}u, where {Lambda} is some {open_quotes}positive{close_quotes} operator. Convergence of the modified SAM without overlapping in a quite general setting has been proven by P.-L.Lions using delicate energy estimates. The important questions remain for the generalized SAM. (1) What is the most essential mechanism for convergence without overlapping? (2) Given the partial differential equation, what is the best choice for the positive operator {Lambda}? (3) In the overlapping case, is the generalized SAM superior to the classical SAM? (4) What is the convergence rate and what does it depend on? (5) Numerically can we obtain an easy to implement operator {Lambda} such that the convergence is independent of the mesh size. To analyze the convergence of the generalized SAM we focus, for simplicity, on the Poisson equation for two typical geometry in two subdomain case.

  18. Numerical Analysis of Emissions from Marine Engines Using Alternative Fuels

    Directory of Open Access Journals (Sweden)

    M.I. Lamas

    2015-12-01

    Full Text Available The current restrictions on emissions from marine engines, particularly sulphur oxides (SOx , nitrogen oxides (NOx and carbon dioxide (CO2 , are compelling the shipping industry to a change of tendency. In the recent years, many primary and secondary reduction techniques have been proposed and employed in marine engines. Nevertheless, the increasingly restrictive legislation makes it very difficult to continue developing efficient reduction procedures at competitive prices. According to this, the paper presents the possibility to employ alternative fuels. A numerical model was developed to analyze the combustion process and emissions using oil fuel, natural gas and hydrogen. A commercial marine engine was studied, the Wärtsilä 6L 46. It was found, that hydrogen is the cleanest fuel regarding CO2 , hydrocarbons (HC and carbon monoxide (CO. Nevertheless, it is very expensive for marine applications. Natural gas is cheaper and cleaner than fuel oil regarding CO2 and CO emissions. Still, natural gas emits more NOx and HC than oil fuel. SOx depends basically on the sulphur content of each particular fuel.

  19. Waste management facility accident analysis (WASTE ACC) system: software for analysis of waste management alternatives

    International Nuclear Information System (INIS)

    This paper describes the Waste Management Facility Accident Analysis (WASTEunderscoreACC) software, which was developed at Argonne National Laboratory (ANL) to support the US Department of Energy's (DOE's) Waste Management (WM) Programmatic Environmental Impact Statement (PEIS). WASTEunderscoreACC is a decision support and database system that is compatible with Microsoft reg-sign Windows trademark. It assesses potential atmospheric releases from accidents at waste management facilities. The software provides the user with an easy-to-use tool to determine the risk-dominant accident sequences for the many possible combinations of process technologies, waste and facility types, and alternative cases described in the WM PEIS. In addition, its structure will allow additional alternative cases and assumptions to be tested as part of the future DOE programmatic decision-making process. The WASTEunderscoreACC system demonstrates one approach to performing a generic, systemwide evaluation of accident risks at waste management facilities. The advantages of WASTEunderscoreACC are threefold. First, the software gets waste volume and radiological profile data that were used to perform other WM PEIS-related analyses directly from the WASTEunderscoreMGMT system. Second, the system allows for a consistent analysis across all sites and waste streams, which enables decision makers to understand more fully the trade-offs among various policy options and scenarios. Third, the system is easy to operate; even complex scenario runs are completed within minutes

  20. Value-impact analysis for material control and accounting alternatives

    International Nuclear Information System (INIS)

    This paper describes the results of Value-Impact analysis for the proposed material control and accounting upgrade rule for Category I fuel facilities. The analysis uses the Aggregated Systems Model (ASM), one of several assessment methodologies developed at Lawrence Livermore National Laboratory (LLNL) under the auspices of the NRC's Office of Nuclear Regulatory Research, to evaluate safeguards decisions. The evaluations are based on data gathered from representative facilities processing special nuclear material (SNM). The paper focuses on an objective of the MCandA upgrade rule of having a 90 percent probability of detecting within 24 hours any large discrepancy of SNM. 3 refs

  1. An Alternative Method to Predict Performance: Canonical Redundancy Analysis.

    Science.gov (United States)

    Dawson-Saunders, Beth; Doolen, Deane R.

    1981-01-01

    The relationships between predictors of performance and subsequent measures of clinical performance in medical school were examined for two classes at Southern Illinois University of Medicine. Canonical redundancy analysis was used to evaluate the association between six academic and three biographical preselection characteristics and four…

  2. Alternative Analysis of Classifications of Universal Managerial Functions

    Directory of Open Access Journals (Sweden)

    Chornii Heorhii M.

    2014-03-01

    Full Text Available The article is devoted to theoretical justification of classification of general managerial functions. Critical analysis of scientific works of eminent specialists in management gave a possibility to find out that classification of functions of the subject of management should be based on the objective cyclic change of the state of information by three stages: appearance of information, its concentration and transformation into a programme of specific actions. The article offers a classification model of the integrated managerial activity in social and mixed systems, which includes differentiation of managerial functions into three orders. Providing information, decision making and realisation of the decision are functions of the second order (basic in this model, while accounting, analysis, goal setting, planning, organisation, management and control – are, consequently, functions of the third order (derivatives. The article considers one specific example from management practice with the aim of verification of the author’s opinion regarding the processed classification of managerial functions.

  3. Alternative Approaches for Rating INDCs: a Comparative Analysis

    OpenAIRE

    Davide, Marinella; Vesco, Paola

    2016-01-01

    The “Intended nationally determined contributions” (INDCs) communicated by both developing and developed countries represent a crucial element of the Paris agreement. This paper aims at analysing the INDCs submitted by Parties, through the different tools and approaches proposed by the research community. In particular, our analysis looks at the different ways to assess the effectiveness of the proposed emission reduction pledges, both in terms of aggregate and national efforts. However, we a...

  4. Configurational analysis as an alternative way of modeling sales response

    OpenAIRE

    Aarnio, Susanna

    2013-01-01

    Objectives of the Study The objectives of the study are both managerial and methodological. On the one hand, the aim is to apply a novel research approach, fuzzy set qualitative comparative analysis or fsQCA (see f. ex. Ragin, 2000; Rihoux & Ragin, 2009), to sales response modeling and thus, create a response model for the case company to identify complex, configurational causalities affecting the company's sales volumes within the chosen product category. On the other hand, to goal is to ...

  5. “Replacing” Problem Behavior: An Analysis of Tactical Alternatives

    OpenAIRE

    James M. Johnston

    2006-01-01

    A number of textbooks and professional volumes in applied behavior analysis suggest that interventions designed primarily to decrease a problem behavior should routinely be accompanied by efforts to increase the frequency of at least one appropriate behavior. Some sources describe the objective of this tactic as “replacing” the problem behavior. This paper considers rationales that might underlie this advice, as well as reasons why a general rule to this effect is inappropriate. This review r...

  6. Alternative Analysis of Classifications of Universal Managerial Functions

    OpenAIRE

    Chornii Heorhii M.; Mishchenko Ivan A.; Faychuk Оlexandr M.

    2014-01-01

    The article is devoted to theoretical justification of classification of general managerial functions. Critical analysis of scientific works of eminent specialists in management gave a possibility to find out that classification of functions of the subject of management should be based on the objective cyclic change of the state of information by three stages: appearance of information, its concentration and transformation into a programme of specific actions. The article offers a classificat...

  7. Welfare Analysis of Pollution Control With Spatial Alternatives

    OpenAIRE

    Vinod Thomas

    1983-01-01

    This paper deals with the welfare losses resulting from emission control policies which do not take into account differences in control costs among firms and in benefits across regions. In contrast, an optimal policy considers these differences, and on their basis, requires differential controls among regions, presumably encouraging spatial adaptation of production. Drawing on an empirical analysis of welfare benefits and welfare costs of controlling particulate emissions from the iron and st...

  8. Low-level waste management alternatives and analysis in DOE`s programmatic environmental impact statement

    Energy Technology Data Exchange (ETDEWEB)

    Gerstein, J.S. [Dept. of Energy, Washington, DC (United States). Office of Environmental Restoration and Waste Management

    1993-03-01

    The Department of Energy is preparing a Programmatic Environmental Impact Statement (PEIS) for the Environmental Restoration and Waste Management Program. The PEIS has been divided into an Environmental Restoration section and a Waste Management section. Each section has a unique set of alternatives. This paper will focus on the waste management alternatives and analysis. The set of alternatives for waste management has been divided into waste categories. These categories are: high-level waste, transuranic waste, low-level waste, low-level mixed waste, greater-than-class C and low-level waste from commercial sources, hazardous waste, and spent nuclear fuel. This paper will discuss the alternatives and analytical approach that will be used to evaluate these alternatives for the low-level waste section. Although the same alternatives will be considered for all waste types, the analysis will be performed separately for each waste type. In the sections that follow, information will be provided on waste management configurations, the analysis of waste management alternatives, waste types and locations, facility and transportation activities, the facility and transportation impacts assessment, and the compilation of impacts.

  9. Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

    Directory of Open Access Journals (Sweden)

    Penny David

    2007-10-01

    Full Text Available Abstract Background Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic groups or was inherited from their last common ancestor, and may therefore predate multicellularity, is still unknown. To better understand the origin and evolution of alternative splicing and its usage in diverse organisms, we studied alternative splicing in 12 eukaryotic species, comparing rates of alternative splicing across genes of different functional classes, cellular locations, intron/exon structures and evolutionary origins. Results For each species, we find that genes from most functional categories are alternatively spliced. Ancient genes (shared between animals, fungi and plants show high levels of alternative splicing. Genes with products expressed in the nucleus or plasma membrane are generally more alternatively spliced while those expressed in extracellular location show less alternative splicing. We find a clear correspondence between incidence of alternative splicing and intron number per gene both within and between genomes. In general, we find several similarities in patterns of alternative splicing across these diverse eukaryotes. Conclusion Along with previous studies indicating intron-rich genes with weak intron boundary consensus and complex spliceosomes in ancestral organisms, our results suggest that at least a simple form of alternative splicing may already have been present in the unicellular ancestor of plants, fungi and animals. A role for alternative splicing in the evolution of multicellularity then would largely have arisen by co-opting the preexisting process.

  10. Coarse-grid-CFD. An advantageous alternative to subchannel analysis

    International Nuclear Information System (INIS)

    In the 1960th to 80th when current GEN II reactor technology was developed, the only possible approach was to use one-dimensional subchannel analysis to compute the flow inside a fuel bundle so that the subchannel scale could be resolved. For simulations of the whole reactor core either system codes or homogenization were employed. In system codes resolution of individual assemblies was the state of the art. Homogenization used porous media equations simulations and averaged the thermohydraulics on reactor core scale. Current potent computing power allows using Computational Fluid Dynamics (CFD) to simulate individual fuel assemblies. Yet the large number of fuel assemblies within the core forbids exploiting CFD for core wide simulation. We propose to combine ideas of subchannel analysis and CFD to develop a new methodology which takes advantage of the fast development of commercial CFD software and the efficiency of subchannel analysis. In this methodology was first applied to simulate a wire-wrap fuel bundle of the High Performance Light Water Reactor (HPLWR). Computations using an inviscid Euler solver on an extremely coarse grid were tuned to predict the true thermohydraulics by adding volumetric forces. These forces represent the non-resolved sub-grid physics. The volumetric forces cannot be measured directly. However, they can be accessed from detailed CFD simulations resolving all relevant physics. Parameterization of these subgrid forces can be realized analogous to models in subchannel codes. In the present work we extend the methodology to the open source solver OpenFOAM and a specific hexagonal fuel assembly which is studied in the framework of liquid metal cooled GEN IV reactor concepts. (orig.)

  11. Preliminary analysis of alternative fuel cycles for proliferation evaluation

    International Nuclear Information System (INIS)

    The ERDA Division of Nuclear Research and Applications proposed 67 nuclear fuel cycles for assessment as to their nonproliferation potential. The object of the assessment was to determine which fuel cycles pose inherently low risk for nuclear weapon proliferation while retaining the major benefits of nuclear energy. This report is a preliminary analysis of these fuel cycles to develop the fuel-recycle data that will complement reactor data, environmental data, and political considerations, which must be included in the overall evaluation. This report presents the preliminary evaluations from ANL, HEDL, ORNL, and SRL and is the basis for a continuing in-depth study

  12. Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing

    DEFF Research Database (Denmark)

    Irimia, Manuel; Rukov, Jakob Lewin; Penny, David;

    2007-01-01

    , and may therefore predate multicellularity, is still unknown. To better understand the origin and evolution of alternative splicing and its usage in diverse organisms, we studied alternative splicing in 12 eukaryotic species, comparing rates of alternative splicing across genes of different functional...... classes, cellular locations, intron/exon structures and evolutionary origins. RESULTS: For each species, we find that genes from most functional categories are alternatively spliced. Ancient genes (shared between animals, fungi and plants) show high levels of alternative splicing. Genes with products...... expressed in the nucleus or plasma membrane are generally more alternatively spliced while those expressed in extracellular location show less alternative splicing. We find a clear correspondence between incidence of alternative splicing and intron number per gene both within and between genomes. In general...

  13. Economic analysis of alternative options in CANDU fuel cycle

    International Nuclear Information System (INIS)

    In this study, fuel cycle options for CANDU reactor were studied. Three main options in a CANDU fuel cycle involve use of : (1) natural uranium (0.711 weight percent U-235) fuel, (2) slightly enriched uranium (1.2 weight percent U-235) fuel, and (3) recovered uranium (0.83 weight percent U-235) fuel from light water reactor spent fuel. ORIGEN-2 computer code was used to identify composition of the spent fuel for each option , including the standard LWR fuel (3.3 weight percent U-235). Uranium and plutonium credit calculations were performed by using ORIGEN-2 output. WIMSD-5 computer code was used to determine maximum discharge burnup values for each case. Cost estimations were carried out using specially-developed computer programs. Comparison of levelized costs for the fuel cycle options and sensitivity analysis for the cost components are also presented

  14. Design of sustainable chemical processes: Systematic retrofit analysis, generation and evaluation alternatives

    DEFF Research Database (Denmark)

    Carvalho, Ana; Gani, Rafiqul; Matos, Henrique

    2008-01-01

    The objective of this paper is to present a generic and systematic methodology for identifying the feasible retrofit design alternatives of any chemical process. The methodology determines a set of mass and energy indicators from steady-state process data, establishes the operational and design...... targets, and through a sensitivity-based analysis, identifies the design alternatives that can match a set of design targets. The significance of this indicator-based method is that it is able to identify alternatives, where one or more performance criteria (factors) move in the same direction thereby...... eliminating the need to identify trade-off-based solutions. These indicators are also able to reduce (where feasible) a set of safety indicators. An indicator sensitivity analysis algorithm has been added to the methodology to define design targets and to generate sustainable process alternatives. A computer...

  15. Multi-Criteria Analysis of Alternative Energy Supply Solutions to Public Nearly Zero Energy Buildings

    Directory of Open Access Journals (Sweden)

    Giedrius Šiupšinskas

    2013-12-01

    Full Text Available The article analyzes energy supply alternatives for modernised public nearly zero energy buildings. The paper examines alternative energy production systems such as heat pumps (air-water and ground-water, solar collectors, adsorption cooling, biomass boiler, solar photovoltaic, wind turbines and combinations of these systems. The simulation of the analysed building energy demand for different energy production alternatives has been performed using TRNSYS modelling software. In order to determine an optimal energy supply variant, the estimated results of energy, environmental, and economic evaluation have been converted into non-dimensional variables (3E using multi-criteria analysis.Article in Lithuanian

  16. INEEL Subsurface Disposal Area CERCLA-based Decision Analysis for Technology Screening and Remedial Alternative Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Parnell, G. S.; Kloeber, Jr. J.; Westphal, D; Fung, V.; Richardson, John Grant

    2000-03-01

    A CERCLA-based decision analysis methodology for alternative evaluation and technology screening has been developed for application at the Idaho National Engineering and Environmental Laboratory WAG 7 OU13/14 Subsurface Disposal Area (SDA). Quantitative value functions derived from CERCLA balancing criteria in cooperation with State and Federal regulators are presented. A weighted criteria hierarchy is also summarized that relates individual value function numerical values to an overall score for a specific technology alternative.

  17. Comprehensive analysis of alternative splicing in rice and comparative analyses with Arabidopsis

    Directory of Open Access Journals (Sweden)

    Mount Stephen M

    2006-12-01

    Full Text Available Abstract Background Recently, genomic sequencing efforts were finished for Oryza sativa (cultivated rice and Arabidopsis thaliana (Arabidopsis. Additionally, these two plant species have extensive cDNA and expressed sequence tag (EST libraries. We employed the Program to Assemble Spliced Alignments (PASA to identify and analyze alternatively spliced isoforms in both species. Results A comprehensive analysis of alternative splicing was performed in rice that started with >1.1 million publicly available spliced ESTs and over 30,000 full length cDNAs in conjunction with the newly enhanced PASA software. A parallel analysis was performed with Arabidopsis to compare and ascertain potential differences between monocots and dicots. Alternative splicing is a widespread phenomenon (observed in greater than 30% of the loci with transcript support and we have described nine alternative splicing variations. While alternative splicing has the potential to create many RNA isoforms from a single locus, the majority of loci generate only two or three isoforms and transcript support indicates that these isoforms are generally not rare events. For the alternate donor (AD and acceptor (AA classes, the distance between the splice sites for the majority of events was found to be less than 50 basepairs (bp. In both species, the most frequent distance between AA is 3 bp, consistent with reports in mammalian systems. Conversely, the most frequent distance between AD is 4 bp in both plant species, as previously observed in mouse. Most alternative splicing variations are localized to the protein coding sequence and are predicted to significantly alter the coding sequence. Conclusion Alternative splicing is widespread in both rice and Arabidopsis and these species share many common features. Interestingly, alternative splicing may play a role beyond creating novel combinations of transcripts that expand the proteome. Many isoforms will presumably have negative

  18. Genome-wide analysis of SRSF10-regulated alternative splicing by deep sequencing of chicken transcriptome

    Directory of Open Access Journals (Sweden)

    Xuexia Zhou

    2014-12-01

    Full Text Available Splicing factor SRSF10 is known to function as a sequence-specific splicing activator that is capable of regulating alternative splicing both in vitro and in vivo. We recently used an RNA-seq approach coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. We found that SRSF10 promoted both exon inclusion and exclusion. Functionally, many of the SRSF10-verified alternative exons are linked to pathways of response to external stimulus. Here we describe in detail the experimental design, bioinformatics analysis and GO/pathway enrichment analysis of SRSF10-regulated genes to correspond with our data in the Gene Expression Omnibus with accession number GSE53354. Our data thus provide a resource for studying regulation of alternative splicing in vivo that underlines biological functions of splicing regulatory proteins in cells.

  19. Alternative Splicing and Expression Profile Analysis of Expressed Sequence Tags in Domestic Pig

    Institute of Scientific and Technical Information of China (English)

    Liang Zhang; Lin Tao; Lin Ye; Ling He; Yuan-Zhong Zhu; Yue-Dong Zhu; Yan Zhou

    2007-01-01

    Domestic pig (Sus scrofa domestica) is one of the most important mammals to humans. Alternative splicing is a cellular mechanism in eukaryotes that greatly increases the diversity of gene products. Expression sequence tags (ESTs) have been widely used for gene discovery, expression profile analysis, and alternative splicing detection. In this study, a total of 712,905 ESTs extracted from 101 different nonnormalized EST libraries of the domestic pig were analyzed. These EST libraries cover the nervous system, digestive system, immune system, and meat production related tissues from embryo, newborn, and adult pigs, making contributions to the analysis of alternative splicing variants as well as expression profiles in various stages of tissues. A modified approach was designed to cluster and assemble large EST datasets, aiming to detect alternative splicing together with EST abundance of each splicing variant. Much efforts were made to classify alternative splicing into different types and apply different filters to each type to get more reliable results. Finally, a total of 1,223 genes with average 2.8 splicing variants were detected among 16,540 unique genes. The overview of expression profiles would change when we take alternative splicing into account.

  20. Hydrogeologic analysis of remedial alternatives for the solar ponds plume, RFETS

    Energy Technology Data Exchange (ETDEWEB)

    McLane, C.F. III; Whidden, J.A. [McLane Environmental, L.L.C., Princeton, NJ (United States); Hopkins, J.K. [Rocky Mountain Remediation Services, Los Alamos, NM (United States)

    1998-07-01

    The focus of this paper is to develop a conceptual model and a hydrogeologic analysis plan for remedial alternatives being considered for the remediation of a ground water contaminant plume consisting of chiefly nitrate and uranium. The initial step in this process was to determine the adequacy of the existing data from the vast database of site information. Upon concluding that the existing database was sufficient to allow for the development of a conceptual model and then constructing the conceptual model, a hydrogeologic analysis plan was developed to evaluate several alternatives for plume remediation. The plan will be implemented using a combination of analytical and simple numerical ground water flow and contaminant transport models. This allows each portion of the study to be addressed using the appropriate tool, without having to develop a large three-dimensional numerical ground water flow and transport model, thereby reducing project costs. The analysis plan will consist of a preliminary phase of screening analyses for each of the remedial alternative scenarios, and a second phase of more comprehensive and in-depth analyses on a selected subset of remedial alternative scenarios. One of the alternatives which will be analyzed is phytoremediation (remediation of soil and ground water via uptake of chemicals by plants) because of the potential for relatively low capital and operation and maintenance costs, passive nature, and potential to provide long-term protection of the surface water. The results of these hydrogeological analyses will be factored into the selection of the preferred remedial alternative, or combination of alternatives, for the contaminant plume.

  1. Hydrogeologic analysis of remedial alternatives for the solar ponds plume, RFETS

    International Nuclear Information System (INIS)

    The focus of this paper is to develop a conceptual model and a hydrogeologic analysis plan for remedial alternatives being considered for the remediation of a ground water contaminant plume consisting of chiefly nitrate and uranium. The initial step in this process was to determine the adequacy of the existing data from the vast database of site information. Upon concluding that the existing database was sufficient to allow for the development of a conceptual model and then constructing the conceptual model, a hydrogeologic analysis plan was developed to evaluate several alternatives for plume remediation. The plan will be implemented using a combination of analytical and simple numerical ground water flow and contaminant transport models. This allows each portion of the study to be addressed using the appropriate tool, without having to develop a large three-dimensional numerical ground water flow and transport model, thereby reducing project costs. The analysis plan will consist of a preliminary phase of screening analyses for each of the remedial alternative scenarios, and a second phase of more comprehensive and in-depth analyses on a selected subset of remedial alternative scenarios. One of the alternatives which will be analyzed is phytoremediation (remediation of soil and ground water via uptake of chemicals by plants) because of the potential for relatively low capital and operation and maintenance costs, passive nature, and potential to provide long-term protection of the surface water. The results of these hydrogeological analyses will be factored into the selection of the preferred remedial alternative, or combination of alternatives, for the contaminant plume

  2. Method for exploiting bias in factor analysis using constrained alternating least squares algorithms

    Science.gov (United States)

    Keenan, Michael R.

    2008-12-30

    Bias plays an important role in factor analysis and is often implicitly made use of, for example, to constrain solutions to factors that conform to physical reality. However, when components are collinear, a large range of solutions may exist that satisfy the basic constraints and fit the data equally well. In such cases, the introduction of mathematical bias through the application of constraints may select solutions that are less than optimal. The biased alternating least squares algorithm of the present invention can offset mathematical bias introduced by constraints in the standard alternating least squares analysis to achieve factor solutions that are most consistent with physical reality. In addition, these methods can be used to explicitly exploit bias to provide alternative views and provide additional insights into spectral data sets.

  3. Demonstration of risk-based decision analysis in remedial alternative selection and design

    Energy Technology Data Exchange (ETDEWEB)

    Evans, E.K.; Duffield, G.M. (Geraghty and Miller Modeling Group, Reston, VA (United States)); Massmann, J.W. (Washington Univ., Seattle, WA (United States)); Freeze, R.A. (Freeze (R.A.) Engineering, Inc., White Rock, BC (Canada)); Stephenson, D.E. (Westinghouse Savannah River Co., Aiken, SC (United States))

    1993-01-01

    This study demonstrates the use of risk-based decision analysis (Massmann and Freeze 1987a, 1987b) in the selection and design of an engineering alternative for groundwater remediation at a waste site at the Savannah River Site, a US Department of Energy facility in South Carolina. The investigation focuses on the remediation and closure of the H-Area Seepage Basins, an inactive disposal site that formerly received effluent water from a nearby production facility. A previous study by Duffield et al. (1992), which used risk-based decision analysis to screen a number of ground-water remediation alternatives under consideration for this site, indicated that the most attractive remedial option is ground-water extraction by wells coupled with surface water discharge of treated effluent. The aim of the present study is to demonstrate the iterative use of risk-based decision analysis throughout the design of a particular remedial alternative. In this study, we consider the interaction between two episodes of aquifer testing over a 6-year period and the refinement of a remedial extraction well system design. Using a three-dimensional ground-water flow model, this study employs (1) geostatistics and Monte Carlo techniques to simulate hydraulic conductivity as a stochastic process and (2) Bayesian updating and conditional simulation to investigate multiple phases of aquifer testing. In our evaluation of a remedial alternative, we compute probabilistic costs associated with the failure of an alternative to completely capture a simulated contaminant plume. The results of this study demonstrate the utility of risk-based decision analysis as a tool for improving the design of a remedial alternative through the course of phased data collection at a remedial site.

  4. Demonstration of risk-based decision analysis in remedial alternative selection and design

    Energy Technology Data Exchange (ETDEWEB)

    Evans, E.K.; Duffield, G.M. [Geraghty and Miller Modeling Group, Reston, VA (United States); Massmann, J.W. [Washington Univ., Seattle, WA (United States); Freeze, R.A. [Freeze (R.A.) Engineering, Inc., White Rock, BC (Canada); Stephenson, D.E. [Westinghouse Savannah River Co., Aiken, SC (United States)

    1993-05-01

    This study demonstrates the use of risk-based decision analysis (Massmann and Freeze 1987a, 1987b) in the selection and design of an engineering alternative for groundwater remediation at a waste site at the Savannah River Site, a US Department of Energy facility in South Carolina. The investigation focuses on the remediation and closure of the H-Area Seepage Basins, an inactive disposal site that formerly received effluent water from a nearby production facility. A previous study by Duffield et al. (1992), which used risk-based decision analysis to screen a number of ground-water remediation alternatives under consideration for this site, indicated that the most attractive remedial option is ground-water extraction by wells coupled with surface water discharge of treated effluent. The aim of the present study is to demonstrate the iterative use of risk-based decision analysis throughout the design of a particular remedial alternative. In this study, we consider the interaction between two episodes of aquifer testing over a 6-year period and the refinement of a remedial extraction well system design. Using a three-dimensional ground-water flow model, this study employs (1) geostatistics and Monte Carlo techniques to simulate hydraulic conductivity as a stochastic process and (2) Bayesian updating and conditional simulation to investigate multiple phases of aquifer testing. In our evaluation of a remedial alternative, we compute probabilistic costs associated with the failure of an alternative to completely capture a simulated contaminant plume. The results of this study demonstrate the utility of risk-based decision analysis as a tool for improving the design of a remedial alternative through the course of phased data collection at a remedial site.

  5. Energy alternatives for irrigation pumping: an economic analysis for northern India.

    OpenAIRE

    Bhatia R

    1984-01-01

    ILO pub-WEP pub. Working paper presenting an economic analysis of alternative energy sources for irrigation pumping in Northern India - considers economic and technical aspects of photovoltaic pumping systems, solar energy systems, electric power, dual-fuel and diesel engines, Biogas and wind power; discusses economic and social development aspects. Abbreviations, bibliography, glossary and tables.

  6. Stiffness analysis and comparison of a Biglide parallel grinder with alternative spatial modular parallelograms

    DEFF Research Database (Denmark)

    Wu, Guanglei; Zou, Ping

    2016-01-01

    This paper deals with the stiffness modeling, analysis and comparison of a Biglide parallel grinder with two alternative modular parallelograms. It turns out that the Cartesian stiffness matrix of the manipulator has the property that it can be decoupled into two homogeneous matrices, correspondi...

  7. Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis

    Directory of Open Access Journals (Sweden)

    Eby Jeanette

    2011-06-01

    Full Text Available Abstract Background An important but understudied component of Canada's health system is alternative care. The objective of this paper is to examine the geographic and socio-demographic characteristics of alternative care consultation in Ontario, Canada's largest province. Methods Data is drawn from the Canadian Community Health Survey (CCHS Cycle 3.1, 2005 for people aged 18 or over (n = 32,598 who had a consultation with an alternative health care provider. Four groups of consultations are examined: (1 all consultations (2 massage therapy (3 acupuncture, and (4 homeopath/naturopath. Descriptive statistics, mapping and logistic regression modeling are employed to analyze the data and to compare modalities of alternative health care use. Results In 2005, more than 1.2 million adults aged 18 or over consulted an alternative health care provider, representing about 13% of the total population of Ontario. The analysis revealed a varied geographic pattern of consultations across the province. Consultations were fairly even across the urban to rural continuum and rural residents were just as likely to consult a provider as their urban counterparts. From a health perspective, people with a chronic condition, lower health status and self-perceived unmet health care needs were more likely to see an alternative health provider. Women with chronic conditions such as fibromyalgia, high blood pressure, chronic fatigue syndrome and chemical sensitivities were more likely to see an alternative provider if they felt their health care needs were not being met. Conclusions The analysis revealed that geography is not a factor in determining alternative health care consultations in Ontario. By contrast, there is a strong association between these consultations and socio-demographic characteristics particularly age, sex, education, health and self-perceived unmet health care needs. The results underscore the importance of women's health needs as related to

  8. Economic analysis of alternatives for optimizing energy use in manufacturing companies

    International Nuclear Information System (INIS)

    The manufacturing companies are one of the main consumers of energy. The increment in global warming and the instability in the petroleum oil market have motivated companies to find alternatives to reduce energy use. In the academic literature several researchers have demonstrated that optimization models can be successfully used to reduce energy use. This research presents the use of an optimization model to identify feasible economic alternatives to reduce energy use. The economic analysis methods used were the payback and the internal rate of return. The optimization model developed in this research was applied and validated using an electronic manufacturing company case study. The results demonstrate that the main variables affecting the economic feasibility of the alternatives are the economic analysis method and the initial implementation costs. Several scenarios were analyzed and the best results show that the manufacturing company could save up to $78,000 in three years if the recommendations based on the optimization model results are implemented. - Highlights: • Evaluate top consumers of energy in manufacturing: A/C, compressed air, and lighting • Economic analysis of alternatives to optimize energy used in manufacturing • Comparison of payback method and internal rate of return method with real data • Results demonstrate that the company could generate savings in energy use

  9. Alternatives generation and analysis for the Phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Claghorn, R.D., Fluor Daniel Hanford

    1997-02-06

    This alternatives generation and analysis (AGA) addresses the question: What is the design basis for the facilities required to stage low-level waste (LLW) feed to the Phase I private contractors? Alternative designs for the intermediate waste feed staging system were developed, analyzed, and compared. Based on these analyses, this document recommends installing mixer pumps in the central pump pit of double-shell tanks 241-AP-102 and 241-AP-104. Also recommended is installing decant/transfer pumps at these tanks. These recommendations have clear advantages in that they provide a low shedule impact/risk and the highest operability of all the alternatives investigated. This revision incorporates comments from the decision board.

  10. A proposed methodology for the analysis and selection of alternatives for the disposition of surplus plutonium

    International Nuclear Information System (INIS)

    The nuclear states are currently involved in the development of comprehensive approaches to the long-term storage and management of fissile materials. A major objective of this effort is to provide a framework for prevention of the proliferation of nuclear weapons. The evaluation should include non-proliferation, economic, technical, institutional, schedule, environmental, and health and safety issues. The ANRCP has proposed that an evaluation of alternatives be guided by the principles of decision analysis, a logical and formal approach to the solution of complicated problems that are too complex to solve informally. This approach would consist of four steps: 1) identification of alternatives and objectives, 2) estimation of the performance of the alternatives with respect to the objectives, 3) development of values and weights for the objectives, and 4) evaluation of the alternatives and sensitivity analysis. In order to facilitate the evaluation process, the ANRCP proposes the use of nine objectives grouped into the following categories: 1) Non-proliferation objectives (which includes resistance to theft and diversion by unauthorized parties, resistance to retrieval and reuse by the host notion, schedule, and fostering progress and cooperation with other nations and Russia); 2) operational effectiveness (which includes cost, technical viability, and other benefits); 3) environmental, safety, and health considerations. In order to evaluate alternatives on the basis of these objectives, they have been clarified through the definition of secondary objectives in some cases. Once the objectives were defined, the next step is to develop measures of performance associated with these objectives. Some of these measures of performance use natural scales, such as cost (dollars), time (months), and environmental impacts (cubic meters of secondary waste). Other measures require specially constructed verbal scales and the performance of each alternative is assessed based on

  11. Evaluation of alternative tissues and equipment for the analysis of neutral and acid detergente fiber.

    Directory of Open Access Journals (Sweden)

    Juliana Santos Farias

    2015-10-01

    Full Text Available The objective of this study was to compare alternative devices and tissues for the determination of neutral detergent fiber (NDF and acid detergent fiber (ADF with the conventional method. Two tissues, nylon (50 μm and TNT (100 g/m², and two devices (fiber digester and autoclave were used for the determination of NDF and ADF content compared to the conventional method. A completely randomized experimental design, which consisted of five treatments and 10 repetitions, was used. The NDF content obtained with TNT in the two devices differed from that obtained with the conventional method (P<0.01. However, the use of nylon in the autoclave and fiber digester provided similar values (P>0.01, indicating this combination as a possible alternative to the conventional method. There was no difference (P>0.01 between the alternative methods for the analysis of NDF. The content of ADF differed between the devices and tissues evaluated (P<0.01. However, the use of nylon tissue in the fiber digester provided values similar to the conventional method (P>0.01 and may be indicated as a practical alternative for the analysis of ADF. The NDF content obtained with nylon tissue, irrespective of the equipment used, and the ADF content obtained with nylon tissue in the fiber digester were similar to the conventional method.

  12. Evaluation of alternative tissues and equipment for the analysis of neutral and acid detergente fiber

    Directory of Open Access Journals (Sweden)

    Rosielen Augusto Patussi

    2015-10-01

    Full Text Available The objective of this study was to compare alternative devices and tissues for the determination of neutral detergent fiber (NDF and acid detergent fiber (ADF with the conventional method. Two tissues, nylon (50 μm and TNT (100 g/m², and two devices (fiber digester and autoclave were used for the determination of NDF and ADF content compared to the conventional method. A completely randomized experimental design, which consisted of five treatments and 10 repetitions, was used. The NDF content obtained with TNT in the two devices differed from that obtained with the conventional method (P<0.01. However, the use of nylon in the autoclave and fiber digester provided similar values (P>0.01, indicating this combination as a possible alternative to the conventional method. There was no difference (P>0.01 between the alternative methods for the analysis of NDF. The content of ADF differed between the devices and tissues evaluated (P<0.01. However, the use of nylon tissue in the fiber digester provided values similar to the conventional method (P>0.01 and may be indicated as a practical alternative for the analysis of ADF. The NDF content obtained with nylon tissue, irrespective of the equipment used, and the ADF content obtained with nylon tissue in the fiber digester were similar to the conventional method.

  13. Life Cycle Multi-Criteria Analysis Of Alternative Energy Supply Systems For A Residential Building

    Directory of Open Access Journals (Sweden)

    Artur Rogoža

    2013-12-01

    Full Text Available The article analyses energy supply alternatives for a partially renovated residential building. In addition to the existing district heating (base case alternative systems, gas boilers, heat pumps (air-water and ground-water, solar collectors, solar cells, and combinations of these systems have been examined. Actual heat consumption of the building and electricity demand determined by the statistical method are used for simulating the systems. The process of simulation is performed using EnergyPro software. In order to select an optimal energy supply option, the life cycle analysis of all systems has been carried out throughout a life span of the building, and the estimated results of energy, environmental and economic evaluation have been converted into non-dimensional variables (3E using multi–criteria analysis.Article in Lithuanian

  14. A brief functional analysis of aggressive and alternative behavior in an outclinic setting.

    OpenAIRE

    Northup, J; Wacker, D; Sasso, G; Steege, M; Cigrand, K; Cook, J; DeRaad, A

    1991-01-01

    We conducted a brief functional analysis to identify maintaining variable for aggressive behavior and an alternative replacement response during a 90-min outpatient evaluation of 3 individuals with severe handicaps. During the initial analogue assessment, which focused on identifying maintaining contingencies for aggressive behavior, each participant displayed a substantially greater frequency of aggressive behavior during one condition than during any other. The contingency that produced the...

  15. Splicing Express: a software suite for alternative splicing analysis using next-generation sequencing data

    OpenAIRE

    Kroll, Jose E.; Kim, JiHoon; Ohno-Machado, Lucila; de Souza, Sandro J.

    2015-01-01

    Motivation. Alternative splicing events (ASEs) are prevalent in the transcriptome of eukaryotic species and are known to influence many biological phenomena. The identification and quantification of these events are crucial for a better understanding of biological processes. Next-generation DNA sequencing technologies have allowed deep characterization of transcriptomes and made it possible to address these issues. ASEs analysis, however, represents a challenging task especially when many dif...

  16. A Statistical Analysis of the Nominative/Accusative Alternation in Japanese : A Preliminary Study

    OpenAIRE

    牧, 秀樹; 森島, 玉峰; マキ, ヒデキ; モリシマ, タマミ; Maki, Hideki; MORISHIMA, Tamami

    2004-01-01

    This paper investigates the Nominative/Accusative alternation exhibited by Japanese stative predicates, which in principle take a Nominative Object. Through a statistical analysis, we found two important facts : (I) that when an Accusative Object is moved to the sentence initial position, some types of stative predicates allow an Accusative Object, and (2) that when the sentence containing a stative predicate and an Accusative Object is embedded into a complex NP, all types of stative predica...

  17. Artificial Neural Network Analysis of Sierpinski Gasket Fractal Antenna: A Low Cost Alternative to Experimentation

    Directory of Open Access Journals (Sweden)

    Balwinder S. Dhaliwal

    2013-01-01

    Full Text Available Artificial neural networks due to their general-purpose nature are used to solve problems in diverse fields. Artificial neural networks (ANNs are very useful for fractal antenna analysis as the development of mathematical models of such antennas is very difficult due to complex shapes and geometries. As such empirical approach doing experiments is costly and time consuming, in this paper, application of artificial neural networks analysis is presented taking the Sierpinski gasket fractal antenna as an example. The performance of three different types of networks is evaluated and the best network for this type of applications has been proposed. The comparison of ANN results with experimental results validates that this technique is an alternative to experimental analysis. This low cost method of antenna analysis will be very useful to understand various aspects of fractal antennas.

  18. A Methodology for the Analysis and Selection of Alternative for the Disposition of Surplus Plutonium

    International Nuclear Information System (INIS)

    The Department of Energy (DOE) - Office of Fissile Materials Disposition (OFMD) has announced a Record of Decision (ROD) selecting alternatives for disposition of surplus plutonium. A major objective of this decision was to further U.S. efforts to prevent the proliferation of nuclear weapons. Other concerns that were addressed include economic, technical, institutional, schedule, environmental, and health and safety issues. The technical, environmental, and nonproliferation analyses supporting the ROD are documented in three DOE reports (DOE-TSR 96, DOE-PEIS 96, and DOE-NN 97, respectively). At the request of OFMD, a team of analysts from the Amarillo National Resource Center for Plutonium (ANRCP) provided an independent evaluation of the alternatives for plutonium that were considered during the evaluation effort. This report outlines the methodology used by the ANRCP team. This methodology, referred to as multiattribute utility theory (MAU), provides a structure for assembling results of detailed technical, economic, schedule, environment, and nonproliferation analyses for OFMD, DOE policy makers, other stakeholders, and the general public in a systematic way. The MAU methodology has been supported for use in similar situations by the National Research Council, an agency of the National Academy of Sciences.1 It is important to emphasize that the MAU process does not lead to a computerized model that actually determines the decision for a complex problem. MAU is a management tool that is one component, albeit a key component, of a decision process. We subscribe to the philosophy that the result of using models should be insights, not numbers. The MAU approach consists of four steps: (1) identification of alternatives, objectives, and performance measures, (2) estimation of the performance of the alternatives with respect to the objectives, (3) development of value functions and weights for the objectives, and (4) evaluation of the alternatives and sensitivity

  19. FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis.

    Science.gov (United States)

    Masuda, Akio; Takeda, Jun-Ichi; Ohno, Kinji

    2016-05-01

    Fused in sarcoma (FUS) is an RNA-binding protein that is causally associated with oncogenesis and neurodegeneration. Recently, the role of FUS in neurodegeneration has been extensively studied, because mutations in FUS are associated with amyotrophic lateral sclerosis (ALS), and the FUS protein has been identified as a major component of intracellular inclusions in neurodegenerative disorders including ALS and frontotemporal lobar degeneration. FUS is a key molecule in transcriptional regulation and RNA processing including processes such as pre-messenger RNA (mRNA) splicing and polyadenylation. Interaction of FUS with various components of the transcription machinery, spliceosome, and the 3'-end processing machinery has been identified. Furthermore, recent advances in high-throughput transcriptomic profiling approaches have enabled us to determine the mechanisms of FUS-dependent RNA processing networks at a cellular level. These analyses have revealed that depletion of FUS in neuronal cells affects alternative splicing and alternative polyadenylation of thousands of mRNAs. Gene ontology analysis has suggested that FUS-modulated genes are implicated in neuronal functions and development. CLIP-seq of FUS has shown that FUS is frequently clustered around these alternative sites of nascent RNA. ChIP-seq of RNA polymerase II (RNAP II) has demonstrated that an interaction between FUS and nascent RNA downregulates local transcriptional activity of RNAP II, which is critically involved in RNA processing. Both alternative splicing and alternative polyadenylation are fundamental processes by which cells expand their transcriptomic diversity, and are particularly essential in the nervous system. Dependence of transcriptomic diversity on FUS makes the nervous system vulnerable to neurodegeneration, when FUS is functionally compromised. WIREs RNA 2016, 7:330-340. doi: 10.1002/wrna.1338 For further resources related to this article, please visit the WIREs website. PMID:26822113

  20. A Methodology for the Analysis and Selection of Alternative for the Disposition of Surplus Plutonium

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-08-31

    The Department of Energy (DOE) - Office of Fissile Materials Disposition (OFMD) has announced a Record of Decision (ROD) selecting alternatives for disposition of surplus plutonium. A major objective of this decision was to further U.S. efforts to prevent the proliferation of nuclear weapons. Other concerns that were addressed include economic, technical, institutional, schedule, environmental, and health and safety issues. The technical, environmental, and nonproliferation analyses supporting the ROD are documented in three DOE reports [DOE-TSR 96, DOE-PEIS 96, and DOE-NN 97, respectively]. At the request of OFMD, a team of analysts from the Amarillo National Resource Center for Plutonium (ANRCP) provided an independent evaluation of the alternatives for plutonium that were considered during the evaluation effort. This report outlines the methodology used by the ANRCP team. This methodology, referred to as multiattribute utility theory (MAU), provides a structure for assembling results of detailed technical, economic, schedule, environment, and nonproliferation analyses for OFMD, DOE policy makers, other stakeholders, and the general public in a systematic way. The MAU methodology has been supported for use in similar situations by the National Research Council, an agency of the National Academy of Sciences.1 It is important to emphasize that the MAU process does not lead to a computerized model that actually determines the decision for a complex problem. MAU is a management tool that is one component, albeit a key component, of a decision process. We subscribe to the philosophy that the result of using models should be insights, not numbers. The MAU approach consists of four steps: (1) identification of alternatives, objectives, and performance measures, (2) estimation of the performance of the alternatives with respect to the objectives, (3) development of value functions and weights for the objectives, and (4) evaluation of the alternatives and sensitivity

  1. Comprehensive splicing graph analysis of alternative splicing patterns in chicken, compared to human and mouse

    Directory of Open Access Journals (Sweden)

    Ranganathan Shoba

    2009-07-01

    Full Text Available Abstract Background Alternative transcript diversity manifests itself as a prime cause of complexity in higher eukaryotes. Recently, transcript diversity studies have suggested that 60–80% of human genes are alternatively spliced. We have used a splicing pattern approach for the bioinformatics analysis of Alternative Splicing (AS in chicken, human and mouse. Exons involved in splicing are subdivided into distinct and variant exons, based on the prevalence of the exons across the transcripts. Four possible permutations of these two different groups of exons were categorised as class I (distinct-variant, class II (distinct-variant, class III (variant-distinct and class IV (variant-variant. This classification quantifies the variation in transcript diversity in the three species. Results In all, 3901 chicken AS genes have been compared with 16,715 human and 16,491 mouse AS genes, with 23% of chicken genes being alternatively spliced, compared to 68% in humans and 57% in mice. To minimize any gene structure bias in the input data, comparative genome analysis has been carried out on the orthologous subset of AS genes for the three species. Gene-level analysis suggested that chicken genes show fewer AS events compared to human and mouse. An event-level analysis showed that the percentage of AS events in chicken is similar to that of human, which implies that a smaller number of chicken genes show greater transcript diversity. Overall, chicken genes were found to have fewer transcripts per gene and shorter introns than human and mouse genes. Conclusion In chicken, the majority of genes generate only two or three isoforms, compared to almost eight in human and six in mouse. We observed that intron definition is expressed strongly when compared to exon definition for chicken genome, based on 3% intron retention in chicken, compared to 2% in human and mouse. Splicing patterns with variant exons account for 33% of AS chicken orthologous genes compared to

  2. Learning Bayesian networks from big meteorological spatial datasets. An alternative to complex network analysis

    Science.gov (United States)

    Gutiérrez, Jose Manuel; San Martín, Daniel; Herrera, Sixto; Santiago Cofiño, Antonio

    2016-04-01

    The growing availability of spatial datasets (observations, reanalysis, and regional and global climate models) demands efficient multivariate spatial modeling techniques for many problems of interest (e.g. teleconnection analysis, multi-site downscaling, etc.). Complex networks have been recently applied in this context using graphs built from pairwise correlations between the different stations (or grid boxes) forming the dataset. However, this analysis does not take into account the full dependence structure underlying the data, gien by all possible marginal and conditional dependencies among the stations, and does not allow a probabilistic analysis of the dataset. In this talk we introduce Bayesian networks as an alternative multivariate analysis and modeling data-driven technique which allows building a joint probability distribution of the stations including all relevant dependencies in the dataset. Bayesian networks is a sound machine learning technique using a graph to 1) encode the main dependencies among the variables and 2) to obtain a factorization of the joint probability distribution of the stations given by a reduced number of parameters. For a particular problem, the resulting graph provides a qualitative analysis of the spatial relationships in the dataset (alternative to complex network analysis), and the resulting model allows for a probabilistic analysis of the dataset. Bayesian networks have been widely applied in many fields, but their use in climate problems is hampered by the large number of variables (stations) involved in this field, since the complexity of the existing algorithms to learn from data the graphical structure grows nonlinearly with the number of variables. In this contribution we present a modified local learning algorithm for Bayesian networks adapted to this problem, which allows inferring the graphical structure for thousands of stations (from observations) and/or gridboxes (from model simulations) thus providing new

  3. Alternative fuels for power generation options in medium-range planning: thermo-economic analysis

    International Nuclear Information System (INIS)

    This study presents alternative-fuel options for power generation for Jordan. The economics of using alternative fuels, i.e. important natural gas, heavy fuel oil and coal as well as local oil shale to supply power plants are compared in terms of medium range production economics. A net present value model was used to compare unit electricity generation cost from different kinds of power plants. Sensitivity analysis was carried out to determine the influence of the most important variable, such as unit capital and fuel prices, discount and inflation rates. The choice of natural gas as a future primary fuel to supply combined cycle gas turbine power stations, in Jordan, is highly recommended. The results of this study agree with those obtained from similar power stations, which are now operating commercially in the international market.(Author)

  4. A 3-D Magnetic Analysis of a Linear Alternator For a Stirling Power System

    Science.gov (United States)

    Geng, Steven M.; Schwarze, Gene E.; Niedra, Janis M.

    2000-01-01

    The NASA Glenn Research Center and the Department of Energy (DOE) are developing advanced radioisotope Stirling convertors, under contract with Stirling Technology Company (STC), for space applications. Of critical importance to the successful development of the Stirling convertor for space power applications is the development of a lightweight and highly efficient linear alternator. This paper presents a 3-D finite element method (FEM) approach for evaluating Stirling convertor linear alternators. Preliminary correlations with open-circuit voltage measurements provide an encouraging level of confidence in the model. Spatial plots of magnetic field strength (H) are presented in the region of the exciting permanent magnets. These plots identify regions of high H, where at elevated temperature and under electrical load, the potential to alter the magnetic moment of the magnets exists. This implies the need for further testing and analysis.

  5. Stochastic Petri nets for the reliability analysis of communication network applications with alternate-routing

    International Nuclear Information System (INIS)

    In this paper, we present a comparative reliability analysis of an application on a corporate B-ISDN network under various alternate-routing protocols. For simple cases, the reliability problem can be cast into fault-tree models and solved rapidly by means of known methods. For more complex scenarios, state space (Markov) models are required. However, generation of large state space models can get very labor intensive and error prone. We advocate the use of stochastic reward nets (a variant of stochastic Petri nets) for the concise specification, automated generation and solution of alternate-routing protocols in networks. This paper is written in a tutorial style so as to make it accessible to a large audience

  6. Bibliometric analysis of scientific production on augmentantive and alternative communication - a research on virtual health library

    Directory of Open Access Journals (Sweden)

    Candice Lima Moreschi

    2013-11-01

    Full Text Available Purpose: To identify the papers whose aim was to study the Alternative Communication issue, of the Virtual Health Library (VHL database from 1981 to 2008. Methodology: documentary research, qualitative and quantitative exploratory descriptive level, that involves the following steps: 1 selection of the descriptor with terminology defined in the Health Science Descriptors (DeCS; 2 survey of literature production about the topic in the VHL Alternative Communication; 3 list the indicators and their correlation: year, author and co-author, country, source of publication; home institutions; objectives and methodological approaches. Results: Although early research in the area are from the ‘50s, only in the '80s that they began to be, in fact, disclosed to academy. The year 1995 is noteworthy for having six of the 24 studies analyzed, developed this year. In the analysis of the authorship of articles, 62.5%were written by multiple authors, and only 37.5% by a single author. The most prominent country was the United States, where sixteen of the twenty-four articles analyzed were written. Regarding the sources of the publication, Journal of Applied Behavior Analysis had 25% of jobs indexed; and concerning the methodological approaches, 50% of the analyzed studies chose the experimental experimental method; 29.16%, documentary approach; and 20.83% were based on approach literature. Conclusion: The interdisciplinary studies in the area of Alternative Communication are noteworthy; appropriate investment resources to the needs of users of Alternative Communication should always be part of the list of researches.

  7. Systemic Functional Linguistics and Discourse Analysis as Alternatives When Dealing With Texts

    Directory of Open Access Journals (Sweden)

    Paula Andrea García Montes

    2014-10-01

    Full Text Available This article presents a case study research with aims to find out which activities, methodological and textual aspects used in a reading strategies course were causing a group of students difficulties when analyzing critically written information. We conducted the study at Universidad de Córdoba (Colombia with seventh semester students from the undergraduate English program. The data collection techniques used included observations, document analysis, interviews, and a Preliminary English Test for students. The results were analyzed taking into account issues in discourse analysis and systemic functional linguistics. Results show reasons why students find it difficult to successfully complete the analysis of written texts. These results can serve as useful alternatives for planning reading lessons.

  8. 75 FR 59323 - Early Scoping for the Alternatives Analysis of the North Corridor Transit Project in Metropolitan...

    Science.gov (United States)

    2010-09-27

    ... Scoping As defined by law, alternatives analysis (AA) is the first step of the New Starts project... next round of regional transit system expansion, voters in 2008 authorized funding for the extension of... transportation alternatives designed to address mobility problems and other locally-identified objectives in...

  9. Evaluation of alternatives for microalgae oil extraction based on exergy analysis

    International Nuclear Information System (INIS)

    Highlights: ► Exergy analysis was used as decision-making tool for evaluation of microalgae oil extraction. ► A robust composition of Chlorella sp. biomass was modeled and used for simulation. ► Three solvent-based microalgae oil extraction methods at large scale were compared. ► Hexane based extraction presented the highest exergetic efficiency. -- Abstract: Several technologies for microalgae oil extraction are being evaluated in order to find the most adequate for large scale microalgae processing. In this work, exergy analysis was used as an instrument for screening three design alternatives for microalgae oil extraction in a large-scale process and as a decision-making tool for evaluation and selection of novel technologies from the energy point of view. Routes were simulated using dedicated industrial process simulation software, taking as feedstock a representative and robust modeled composition of Chlorella sp. microalgae biomass. Mass, energy and exergy balances were performed for each alternative, and physical and chemical exergies of streams and all specific microalgae constituents modeled were calculated with the help of the thermodynamic properties of biomass components and operating conditions of streams. Exergetic efficiencies, total process irreversibilities, energy consumption and exergy destruction were calculated for all solvent-based microalgae oil extraction pathways evaluated. It was shown that exergy analysis led to identify the hexane-based oil extraction (HBE) as the most adequate alternative of the routes assessed for scaling up from the energy point of view, presenting a maximum exergy efficiency of 51% and exergetic losses of 982,000 MJ considering a production of 104,000 t of microalgae oil per year.

  10. Analysis of availability of previously identified sites under alternative demographic criteria

    International Nuclear Information System (INIS)

    This study evaluates the effect of various alternative population criteria on the availability of suitable sites for new nuclear power plants. The population criteria investigated include population density limits of 500 and 750 persons per square mile within 30 miles of the site and three different limits on the total population in adjacent sectors. The site availability in the states with higher population density was investigated - using power pools, regional aggregations, and specific sites as appropriate. The results of this study indicate that the application of any of the alternative population criteria studied will not rule out the use of the nuclear option in the northeast quadrant of the United States. The analysis demonstrates that viable sites exist even in the states and service areas with the largest population densities. These results, together with a cursory examination of the rest of the United States indicating that both real and potential viable sites are available, confirms that the application of any of the alternative population criteria studied will not preclude the identification of suitable nuclear sites in any region

  11. Technico-economic analysis of uranium-mill-tailings conditioning alternatives

    International Nuclear Information System (INIS)

    An analysis of practicable conditioning technologies for uranium mill tailings and their estimated costs has been conducted for two conditioning alternatives, thermal stabilization and leaching (sulfuric acid). Among the four high priority remedial action sites, Canonsburg, Pennsylvania, and Shiprock, New Mexico appear to be very good candidates for thermal stabilization. At Shiprock, thermal stabilization appears to be less expensive ($16.01/ton) than moving the pile more than five miles and covering with 15 feet of earth. At Canonsburg costs of other alternatives are not presently available. Given the radiological monitoring and protection expenses attendant upon moving these tailings in a highly populated area, it is likely that thermal stabilization, on site, at $41.25/ton would be an attractive remedial action approach. Cost data on the Salt Lake City, Utah site are presented for comparison purposes. Thermal stabilization is not favorable at this site because of high fuel and labor costs, as well as other factors. A conceptual design for a thermal stabilization operation is described. Sufficient information to assess the leaching alternative is available only for the Durango, Colorado site. Because of the large amount of vanadium and uranium in the pile, the income from the sale of these strategic minerals could pay for as much as 58% of the expense of removing, transporting, and covering the pile

  12. Hanford tanks initiative alternatives generation and analysis plan for AX tank farm closure basis

    International Nuclear Information System (INIS)

    The purpose of this document is: (1) to review the HTI Mission Analysis and related documents to determine their suitability for use in developing performance measures for AX Tank Farm closure, (2) to determine the completeness and representativeness of selected alternative closure scenarios, (3) to determine the completeness of current plans for development of tank end-state criteria, and (4) to analyze the activities that are necessary and sufficient to recommend the end-state criteria and performance measures for the AX Tank Farm and recommend activities not currently planned to support establishment of its end-state criteria

  13. The Analysis of Fisher Hypothesis in Terms of Turkish Economy Through Alternative Interest Rates

    Directory of Open Access Journals (Sweden)

    Fuat Lebe

    2016-06-01

    Full Text Available The purpose of this study is to analyze the relationship between the interest rate and inflation rate in the context of Fisher hypothesis (1930 by using the data regarding Turkish Economy Differing from the available literature, the validity of Fisher hypothesis for Turkey was assessed according to the alternative interest rates (rediscount interest rate, deposit interest rate and the monetary policy interest rate. The long-term relationship among variables was analyzed via ARDL bound test. As a result of this analysis, it was determined that a stronger Fisher impact is valid for Turkish economy when the monetary interest rate is based as interest rate.

  14. Stability Analysis of Ranking Alternatives Based on Subjective and Objective Weight

    Institute of Scientific and Technical Information of China (English)

    JIANG Yan; ZUO Bao-he; YUE Chao-yuan

    2002-01-01

    Weights of criteria are used to assess the relative importance of the different criteria in multicriteria analysis, which can influence ranking result more or less depending on the multicriteria decisionmaking method used. In this paper, the influences of alternatives' ranking result associated with the change of weight are discussed by making use of the concept of weight stability intervals based on subjective and objective integrated weighting approach. Meamwhile, A model of weight proportion stability intervals is proposed. a numeral example is used to illuminate how many increment of objective weight can change the ranking results determined by subjective weight.

  15. Visions of Alternative (Unpredictable Futures and Their Use in Policy Analysis

    Directory of Open Access Journals (Sweden)

    Robert Costanza

    2000-07-01

    Full Text Available The most critical task facing humanity today is the creation of a shared vision of a sustainable and desirable society, one that can provide permanent prosperity within the biophysical constraints of the real world in a way that is fair and equitable to all of humanity, to other species, and to future generations. Recent work with businesses and communities indicates that creating a shared vision is the most effective engine for change in the desired direction, yet most effort in "futures modeling" has focused on extrapolating past trends rather than envisioning alternative futures. Science and economics as applied to policy are in conflict more often over alternative visions of the world than purely "scientific" disagreements. Likewise, governance has gotten bogged down in mediating short term conflicts between special interests rather than its more basic role of creating broadly shared visions that can guide dispute resolution. This paper addresses the question of what policies are most appropriate for society now, given alternative visions of the future and the enormous uncertainty about the reality of the assumptions underlying these visions. Four specific visions are laid out as being representative of the major alternatives. For each vision the benefits of achieving the vision, the assumptions that would have to be true in order for it to be achieved, and the implications of it being attempted but not achieved are explored. It is argued that dealing with uncertainty about the nature of the world, its carrying capacity for humans, the impacts of climate change, and other aspects of its future can best be done at this level of future visions and assumptions, not at more detailed levels (like the parameter uncertainty in models. Application of this vision/uncertainty analysis can help us both to design the future society we want and to maximize the chances of our getting there safely.

  16. Radiological impacts of Jackpile-Paguate uranium mines: an analysis of alternatives of decommissioning

    International Nuclear Information System (INIS)

    Potential pathways of radiation exposure and radiation-induced genetic and somatic effects from materials at the mine complex under five alternatives of decommissioning were analyzed using UDAD and PRIM computer codes. The principal pathways of exposure included in the analysis were inhalation of airborne radionuclides, ingestion of food and water containing radionuclides, and extended exposure to gamma and beta radiation from either airborne or ground-deposited radionuclides. The alternatives of decommissioning include (A) No Action (site will be fenced, otherwise left as it is), (B) No Future Use (site will be fenced and all disturbed area will be covered with 30 cm of soil, no grazing on the site); (C1) Grazing Land Use as developed by Anaconda Company (protore, waste piles, and open pits covered with 120 cm of soil, the remainder of the disturbed areas covered with 30 cm of soil, pits backfilled 90 cm above the equilibrium groundwater recovery level, no human habitation or farming allowed on the mine site, but grazing would be allowed); (C2) Grazing Land Use as developed by US Department of the Interior (similar to Alternative C1, but the pits covered with 300 cm of soil above the groundwater recovery level); and (D) Maximum Future Use (similar to Alternative C2, except construction of commercial and industrial facilities, storage, recreation, and further mining would be allowed). Radiation doses from atmospheric transport and ingestion of radionuclides were calculated, and somatic and genetic effects in individuals living within 80 km from the mine complex were predicted. Hydrological flow patterns in the mine area were analyzed to determine the potential for future contamination of surface water and groundwater and to determine the groundwater recovery level after reclamation, thus permitting incorporation of corrective actions into the reclamation procedures

  17. Comparative life-cycle cost analysis for low-level mixed waste remediation alternatives

    International Nuclear Information System (INIS)

    The purpose of this study is two-fold: (1) to develop a generic, life-cycle cost model for evaluating low-level, mixed waste remediation alternatives, and (2) to apply the model specifically, to estimate remediation costs for a site similar to the Fernald Environmental Management Project near Cincinnati, OH. Life-cycle costs for vitrification, cementation, and dry removal process technologies are estimated. Since vitrification is in a conceptual phase, computer simulation is used to help characterize the support infrastructure of a large scale vitrification plant. Cost estimating relationships obtained from the simulation data, previous cost estimates, available process data, engineering judgment, and expert opinion all provide input to an Excel based spreadsheet for generating cash flow streams. Crystal Ball, an Excel add-on, was used for discounting cash flows for net present value analysis. The resulting LCC data was then analyzed using multi-attribute decision analysis techniques with cost and remediation time as criteria. The analytical framework presented allows alternatives to be evaluated in the context of budgetary, social, and political considerations. In general, the longer the remediation takes, the lower the net present value of the process. This is true because of the time value of money and large percentage of the costs attributed to storage or disposal

  18. Frequency-based image analysis of random patterns: an alternative way to classical stereocorrelation

    CERN Document Server

    Molimard, Jérôme; Zahouani, Hassan

    2013-01-01

    The paper presents an alternative way to classical stereocorrelation. First, 2D image processing of random patterns is described. Sub-pixel displacements are determined using phase analysis. Then distortion evaluation is presented. The distortion is identified without any assumption on the lens model because of the use of a grid technique approach. Last, shape measurement and shape variation is caught by fringe projection. Analysis is based on two pin-hole assumptions for the video-projector and the camera. Then, fringe projection is coupled to in-plane displacement to give rise to 3D measurement set-up. Metrological characterization shows a resolution comparable to classical (stereo) correlation technique (1/100th pixel). Spatial resolution seems to be an advantage of the method, because of the use of temporal phase stepping (shape measurement, 1 pixel) and windowed Fourier transform (in plane displacements measurement, 9 pixels). Two examples are given. First one is the study of skin properties; second one ...

  19. Towards for Analyzing Alternatives of Interaction Design Based on Verbal Decision Analysis of User Experience

    Directory of Open Access Journals (Sweden)

    Marília Soares Mendes

    2010-04-01

    Full Text Available In domains (as digital TV, smart home, and tangible interfaces that represent a new paradigm of interactivity, the decision of the most appropriate interaction design solution is a challenge. HCI researchers have promoted in their works the validation of design alternative solutions with users before producing the final solution. User experience with technology is a subject that has also gained ground in these works in order to analyze the appropriate solution(s. Following this concept, a study was accomplished under the objective of finding a better interaction solution for an application of mobile TV. Three executable applications of mobile TV prototypes were built. A Verbal Decision Analysis model was applied on the investigations for the favorite characteristics in each prototype based on the user’s experience and their intentions of use. This model led a performance of a qualitative analysis which objectified the design of a new prototype.

  20. Alternative model for assessment administration and analysis: An example from the E-CLASS

    CERN Document Server

    Wilcox, Bethany R; Hobbs, Robert D; Aiken, John M; Welch, Nathan M; Lewandowski, H J

    2016-01-01

    The primary model for dissemination of conceptual and attitudinal assessments that has been used within the physics education research (PER) community is to create a high quality, validated assessment, make it available for a wide range of instructors to use, and provide minimal (if any) support to assist with administration or analysis of the results. Here, we present and discuss an alternative model for assessment dissemination, which is characterized by centralized data collection and analysis. This model also provides a greater degree of support for both researchers and instructors. Specifically, we describe our experiences developing a centralized, automated system for an attitudinal assessment we previously created to examine students' epistemologies and expectations about experimental physics. This system provides a proof-of-concept that we use to discuss the advantages associated with centralized administration and data collection for research-based assessments in PER. We also discuss the challenges t...

  1. Strategies for cost-effective carbon reductions: A sensitivity analysis of alternative scenarios

    International Nuclear Information System (INIS)

    Analyses of alternative futures often present results for a limited set of scenarios, with little if any sensitivity analysis to identify the factors affecting the scenario results. This approach creates an artificial impression of certainty associated with the scenarios considered, and inhibits understanding of the underlying forces. This paper summarizes the economic and carbon savings sensitivity analysis completed for the Scenarios for a Clean Energy Future study (IWG, 2000). Its 19 sensitivity cases provide insight into the costs and carbon-reduction impacts of a carbon permit trading system, demand-side efficiency programs, and supply-side policies. Impacts under different natural gas and oil price trajectories are also examined. The results provide compelling evidence that policy opportunities exist to reduce carbon emissions and save society money

  2. Alternative model for administration and analysis of research-based assessments

    Science.gov (United States)

    Wilcox, Bethany R.; Zwickl, Benjamin M.; Hobbs, Robert D.; Aiken, John M.; Welch, Nathan M.; Lewandowski, H. J.

    2016-06-01

    Research-based assessments represent a valuable tool for both instructors and researchers interested in improving undergraduate physics education. However, the historical model for disseminating and propagating conceptual and attitudinal assessments developed by the physics education research (PER) community has not resulted in widespread adoption of these assessments within the broader community of physics instructors. Within this historical model, assessment developers create high quality, validated assessments, make them available for a wide range of instructors to use, and provide minimal (if any) support to assist with administration or analysis of the results. Here, we present and discuss an alternative model for assessment dissemination, which is characterized by centralized data collection and analysis. This model provides a greater degree of support for both researchers and instructors in order to more explicitly support adoption of research-based assessments. Specifically, we describe our experiences developing a centralized, automated system for an attitudinal assessment we previously created to examine students' epistemologies and expectations about experimental physics. This system provides a proof of concept that we use to discuss the advantages associated with centralized administration and data collection for research-based assessments in PER. We also discuss the challenges that we encountered while developing, maintaining, and automating this system. Ultimately, we argue that centralized administration and data collection for standardized assessments is a viable and potentially advantageous alternative to the default model characterized by decentralized administration and analysis. Moreover, with the help of online administration and automation, this model can support the long-term sustainability of centralized assessment systems.

  3. High Altitude Long Endurance Air Vehicle Analysis of Alternatives and Technology Requirements Development

    Science.gov (United States)

    Nickol, Craig L.; Guynn, Mark D.; Kohout, Lisa L.; Ozoroski, Thomas A.

    2007-01-01

    The objective of this study was to develop a variety of High Altitude Long Endurance (HALE) Unmanned Aerial Vehicle (UAV) conceptual designs for two operationally useful missions (hurricane science and communications relay) and compare their performance and cost characteristics. Sixteen potential HALE UAV configurations were initially developed, including heavier-than-air (HTA) and lighter-than-air (LTA) concepts with both consumable fuel and solar regenerative (SR) propulsion systems. Through an Analysis of Alternatives (AoA) down select process, the two leading consumable fuel configurations (one each from the HTA and LTA alternatives) and an HTA SR configuration were selected for further analysis. Cost effectiveness analysis of the consumable fuel configurations revealed that simply maximizing vehicle endurance can lead to a sub-optimum system solution. An LTA concept with a hybrid propulsion system (solar arrays and a hydrogen-air proton exchange membrane fuel cell) was found to have the best mission performance; however, an HTA diesel-fueled wing-body-tail configuration emerged as the preferred consumable fuel concept because of the large size and technical risk of the LTA concept. The baseline missions could not be performed by even the best HTA SR concept. Mission and SR technology trade studies were conducted to enhance understanding of the potential capabilities of such a vehicle. With near-term technology SR-powered HTA vehicles are limited to operation in favorable solar conditions, such as the long days and short nights of summer at higher latitudes. Energy storage system specific energy and solar cell efficiency were found to be the key technology areas for enhancing HTA SR performance.

  4. Second law analysis of reverse osmosis desalination plants: An alternative design using pressure retarded osmosis

    International Nuclear Information System (INIS)

    A second law analysis of a reverse osmosis desalination plant is carried out using reliable seawater exergy formulation instead of a common model in literature that represents seawater as an ideal mixture of liquid water and solid sodium chloride. The analysis is performed using reverse osmosis desalination plant data and compared with results previously published using the ideal mixture model. It is demonstrated that the previous model has serious shortcomings, particularly with regard to calculation of the seawater flow exergy, the minimum work of separation, and the second law efficiency. The most up-to-date thermodynamic properties of seawater, as needed to conduct an exergy analysis, are given as correlations in this paper. From this new analysis, it is found that the studied reverse osmosis desalination plant has very low second law efficiency (<2%) even when using the available energy recovery systems. Therefore, an energy recovery system is proposed using the (PRO) pressure retarded osmotic method. The proposed alternative design has a second law efficiency of 20%, and the input power is reduced by 38% relative to original reverse osmosis system. -- Highlights: ► A previously proposed model for the calculation of seawater flow exergy gives incorrect values. ► Reverse osmosis desalination plants have very low second law efficiency (<2%) even when using the available energy recovery systems. ► A PRO energy recovery device increases the RO plant’s second law efficiency to 20% and reduces the input power.

  5. Bayesian Factor Analysis as a Variable-Selection Problem: Alternative Priors and Consequences.

    Science.gov (United States)

    Lu, Zhao-Hua; Chow, Sy-Miin; Loken, Eric

    2016-01-01

    Factor analysis is a popular statistical technique for multivariate data analysis. Developments in the structural equation modeling framework have enabled the use of hybrid confirmatory/exploratory approaches in which factor-loading structures can be explored relatively flexibly within a confirmatory factor analysis (CFA) framework. Recently, Muthén & Asparouhov proposed a Bayesian structural equation modeling (BSEM) approach to explore the presence of cross loadings in CFA models. We show that the issue of determining factor-loading patterns may be formulated as a Bayesian variable selection problem in which Muthén and Asparouhov's approach can be regarded as a BSEM approach with ridge regression prior (BSEM-RP). We propose another Bayesian approach, denoted herein as the Bayesian structural equation modeling with spike-and-slab prior (BSEM-SSP), which serves as a one-stage alternative to the BSEM-RP. We review the theoretical advantages and disadvantages of both approaches and compare their empirical performance relative to two modification indices-based approaches and exploratory factor analysis with target rotation. A teacher stress scale data set is used to demonstrate our approach. PMID:27314566

  6. Comparison of Merging and Meta-Analysis as Alternative Approaches for Integrative Gene Expression Analysis

    OpenAIRE

    Jonatan Taminau; Cosmin Lazar; Stijn Meganck; Ann Nowé

    2014-01-01

    An increasing amount of microarray gene expression data sets is available through public repositories. Their huge potential in making new findings is yet to be unlocked by making them available for large-scale analysis. In order to do so it is essential that independent studies designed for similar biological problems can be integrated, so that new insights can be obtained. These insights would remain undiscovered when analyzing the individual data sets because it is well known that the small...

  7. Computational Analysis of an Evolutionarily Conserved VertebrateMuscle Alternative Splicing Program

    Energy Technology Data Exchange (ETDEWEB)

    Das, Debopriya; Clark, Tyson A.; Schweitzer, Anthony; Marr,Henry; Yamamoto, Miki L.; Parra, Marilyn K.; Arribere, Josh; Minovitsky,Simon; Dubchak, Inna; Blume, John E.; Conboy, John G.

    2006-06-15

    A novel exon microarray format that probes gene expression with single exon resolution was employed to elucidate critical features of a vertebrate muscle alternative splicing program. A dataset of 56 microarray-defined, muscle-enriched exons and their flanking introns were examined computationally in order to investigate coordination of the muscle splicing program. Candidate intron regulatory motifs were required to meet several stringent criteria: significant over-representation near muscle-enriched exons, correlation with muscle expression, and phylogenetic conservation among genomes of several vertebrate orders. Three classes of regulatory motifs were identified in the proximal downstream intron, within 200nt of the target exons: UGCAUG, a specific binding site for Fox-1 related splicing factors; ACUAAC, a novel branchpoint-like element; and UG-/UGC-rich elements characteristic of binding sites for CELF splicing factors. UGCAUG was remarkably enriched, being present in nearly one-half of all cases. These studies suggest that Fox and CELF splicing factors play a major role in enforcing the muscle-specific alternative splicing program, facilitating expression of a set of unique isoforms of cytoskeletal proteins that are critical to muscle cell differentiation. Supplementary materials: There are four supplementary tables and one supplementary figure. The tables provide additional detailed information concerning the muscle-enriched datasets, and about over-represented oligonucleotide sequences in the flanking introns. The supplementary figure shows RT-PCR data confirming the muscle-enriched expression of exons predicted from the microarray analysis.

  8. A stochastic alternating renewal process model for unavailability analysis of standby safety equipment

    International Nuclear Information System (INIS)

    The paper presents a stochastic approach to analyze instantaneous unavailability of standby safety equipment caused by latent failures. The problem of unavailability analysis is formulated as a stochastic alternating renewal process without any restrictions on the form of the probability distribution assigned to time to failure and repair duration. An integral equation for point unavailability is derived and numerically solved for a given maintenance policy. The paper also incorporates an age-based preventive maintenance policy with random repair time. In case of aging equipment, the asymptotic limit or average unavailability should be used with a caution, because it cannot model an increasing trend in unavailability as a result of increasing hazard rate (i.e. aging) of the time to failure distribution. - Highlights: • Analyzes unavailability as a stochastic alternating renewal process. • Derives a renewal integral equations for computing instantaneous unavailability. • Includes general distributions for failure and repair times. • Analyzes unavailability under an age-based preventive maintenance policy. • Shows average unavailability that cannot capture the equipment aging effect

  9. Cloning and Alternative Splicing Analysis of Bombyx mori Transformer-2 Gene using Silkworm EST Database

    Institute of Scientific and Technical Information of China (English)

    Bao-Long NIU; Zhi-Qi MENG; Yue-Zhi TAO; Shun-Lin LU; Hong-Biao WENG; Li-Hua HE; Wei-Feng SHEN

    2005-01-01

    We have identified Bombyx mori transformer-2 gene (Bmtra-2) cDNA by blasting the EST database of B. mori. It was expressed in the whole life of the male and female silkworm and was observed as a band of 1.3 kb by Northern blot analysis. By comparing corresponding ESTs to the Bmtra-2 DNA sequence,it was revealed that there were eight exons and seven introns, and all splice sites of exons/introns conformed to the GT/AG rule. Bmtra-2 pre-mRNA can produce multiple mRNAs encoding six distinct isoforms of BmTRA-2 protein using an alternative splicing pathway during processing. Six types of Bmtra-2 cDNA clones were identified by reverse transcription-polymerase chain reaction. All isoforms of BmTRA-2 protein contain two arginine/serine-rich domains and one RNA recognition motif, showing striking organizational similarity to Drosophila TRA-2 proteins.

  10. An alternative transformation in ranking using l_1 -norm in data envelopment analysis

    Science.gov (United States)

    Ziari, S.

    2016-05-01

    Jahanshahloo et al. (Appl Math Comput 153:215-224, 2004) propose a method for ranking extremely efficient decision making units (DMUs) in data envelopment analysis (DEA) using super-efficiency technique and l1-norm and they show that the presented method is able to eliminate the existing difficulties in some methods. This paper suggests an alternative transformation to convert the nonlinear model proposed by Jahanshahloo et al. (Appl Math Comput 153:215-224, 2004) into a linear programming form. The present paper shows that model with this transformation is equivalent to the above-mentioned nonlinear model. The motivation of this work is to linearize the proposed nonlinear model by Jahanshahloo et al. (Appl Math Comput 153:215-224, 2004) which has the higher order of complexity.

  11. An Alternative Dimension Reduction Approach to Supervised Principal Components Analysis in High Dimensional Survival Data

    Directory of Open Access Journals (Sweden)

    Elvan AKTURK HAYAT

    2016-04-01

    Full Text Available Objective: This study aims at comparing the performances of supervised principal component analysis (SPCA which is used for dimension reduction and an alternatively proposed approach of nonlinear principal component analysis using artificial neural networks performed by gene selection with survival tree (survival tree based NLPCA- NN. Material and Methods: Gene expression data set from Rosenwald et al.(2002 pertaining to 240 patients with diffuse large B-cell lymphoma (DLBCL is used. While Cox scores are used for determining important genes from high dimensional gene expression data in SPCA, in survival tree based NLPCA-NN approach, importance values of the survival tree are used. Important genes according to the Cox scores are reduced to three principal components by singular value decomposition. Important genes determined by the survival tree are taken as input variables in neural networks and reduced to three principal components. The performances of SPCA and survival tree based NLPCA-NN are compared by using Cox regression models (CRM. C index is calculated to compare obtained Cox regression models. Results: According to Cox scores, 121 genes are determined; according to importance values of survival tree 114 genes are determined. The percentages of variances explained by SPCA and survival tree based NLPCA-NN were 18.2% and 35.1% respectively. Harrell?s C indexes are calculated as 0.726 for CRM-1, 0.687 for CRM-2. Conclusion: As a result, while SPCA takes only the linear relationships into consideration, survival tree based NLPCA-NN also takes non-linear relationships into account and has more variance explanation and NLPCA-NN can be evaluated as an alternative method to SPCA.

  12. Genome-wide analysis of shoot growth-associated alternative splicing in moso bamboo.

    Science.gov (United States)

    Li, Long; Hu, Tao; Li, Xueping; Mu, Shaohua; Cheng, Zhanchao; Ge, Wei; Gao, Jian

    2016-08-01

    Alternative splicing (AS) significantly enhances transcriptome complexity and is differentially regulated in a wide variety of physiological processes in plants, including shoot growth. Presently, the functional implications and conservation of AS occurrences are not well understood in the moso bamboo genome. To analyze the global changes in AS during moso bamboo shoot growth, fast-growing shoots collected at seven different heights and culms after leaf expansion were sequenced using the Illumina HiSeq™ 2000 sequencing platform. It was found that approximately 60.74 % of all genes were alternatively spliced, with intron retention (IR) being the most frequent AS event (27.43 %). Statistical analysis demonstrated that variations of AS frequency and AS types were significantly correlated with changes in gene features and gene transcriptional level. According to the phylogenetic analysis of isoform expression data and AS frequency, the bamboo shoot growth could be divided into four different growth periods, including winter bamboo shoot (S1), early growth period (S2-S5), late growth period (S6 and S7), and mature period (CK). In addition, our data also showed that the winter bamboo shoot had the highest number of AS events. Twenty-six putative Serine/arginine-rich (SR) proteins were identified, producing a total of 109 transcripts. AS events were frequently and specifically regulated by SR splicing factors throughout shoot growth, resulting in changes to the original open reading frame (ORF) and subsequently changes to conserved domains. The AS product-isoforms showed regular expression change during the whole shoot growth period, thus influencing shoot growth. All together, these data indicate that AS events are adjusted to different growth stages, providing briefness and efficient means of gene regulation. This study will provide a very useful clue for future functional analyses. PMID:27170010

  13. Regional economic analysis of current and proposed management alternatives for Rappahannock River Valley National Wildlife Refuge

    Science.gov (United States)

    Koontz, Lynne; Sexton, Natalie; Donovan, Ryan

    2009-01-01

    The National Wildlife Refuge System Improvement Act of 1997 requires all units of the National Wildlife Refuge System to be managed under a Comprehensive Conservation Plan. The Comprehensive Conservation Plan must describe the desired future conditions of a refuge and provide long-range guidance and management direction to achieve refuge purposes. The Rappahannock River Valley National Wildlife Refuge (refuge) is in the process of developing a range of management goals, objectives, and strategies for the Comprehensive Conservation Plan. The Comprehensive Conservation Plan for the refuge must contain an analysis of expected effects associated with current and proposed refuge management strategies. The purpose of this study was to assess the regional economic implications associated with draft Comprehensive Conservation Plan management strategies. Special interest groups and local residents often criticize a change in refuge management, especially if there is a perceived negative impact to the local economy. Having objective data on economic impacts may show that these fears are overstated. Quite often, the extent of economic benefits a refuge provides to a local community is not fully recognized, yet at the same time the effects of negative changes is overstated. Spending associated with refuge recreational activities, such as wildlife viewing and hunting, can generate considerable tourist activity for surrounding communities. Additionally, refuge personnel typically spend considerable amounts of money purchasing supplies in local stores, repairing equipment and purchasing fuel at the local service stations, and reside and spend their salaries in the local community. For refuge Comprehensive Conservation Plan planning, a regional economic assessment provides a means of estimating how current management (no action alternative) and proposed management activities (alternatives) could affect the local economy. This type of analysis provides two critical pieces of

  14. Analysis of Alternatives for Dismantling of the Equipment in Building 117/1 at Ignalina NPP - 13278

    Energy Technology Data Exchange (ETDEWEB)

    Poskas, Povilas; Simonis, Audrius [Lithuanian Energy Institute, Kaunas (Lithuania); Poskas, Gintautas [Lithuanian Energy Institute, Kaunas (Lithuania); Kaunas University of Technology, Kaunas (Lithuania)

    2013-07-01

    Ignalina NPP was operating two RBMK-1500 reactors which are under decommissioning now. In this paper dismantling alternatives of the equipment in Building 117/1 are analyzed. After situation analysis and collection of the primary information related to components' physical and radiological characteristics, location and other data, two different alternatives for dismantling of the equipment are formulated - the first (A1), when major components (vessels and pipes of Emergency Core Cooling System - ECCS) are segmented/halved in situ using flame cutting (oxy-acetylene) and the second one (A2), when these components are segmented/halved at the workshop using CAMC (Contact Arc Metal Cutting) technique. To select the preferable alternative MCDA method - AHP (Analytic Hierarchy Process) is applied. Hierarchical list of decision criteria, necessary for assessment of alternatives performance, are formulated. Quantitative decision criteria values for these alternatives are calculated using software DECRAD, which was developed by Lithuanian Energy Institute Nuclear engineering laboratory. While qualitative decision criteria are evaluated using expert judgment. Analysis results show that alternative A1 is better than alternative A2. (authors)

  15. Transient analysis of unbalanced short circuits of the ERDA-NASA 100 kW wind turbine alternator

    Science.gov (United States)

    Hwang, H. H.; Gilbert, L. J.

    1976-01-01

    Unbalanced short-circuit faults on the alternator of the ERDA-NASA Mod-O100-kW experimental wind turbine are studied. For each case, complete solutions for armature, field, and damper-circuit currents; short-circuit torque; and open-phase voltage are derived directly by a mathematical analysis. Formulated results are tabulated. For the Mod-O wind turbine alternator, numerical calculations are given, and results are presented by graphs. Comparisons for significant points among the more important cases are summarized. For these cases the transients are found to be potentially severe. The effect of the alternator neutral-to-ground impedance is evaluated.

  16. 76 FR 37014 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe...

    Science.gov (United States)

    2011-06-24

    ... expedited methods approval action for determining dalapon in drinking water (75 FR 32295, June 8, 2010... the Safe Drinking Water Act; Analysis and Sampling Procedures. 75 FR 32295. June 8, 2010. List of... AGENCY 40 CFR Part 141 Expedited Approval of Alternative Test Procedures for the Analysis of...

  17. On the analysis of clonogenic survival data: Statistical alternatives to the linear-quadratic model

    International Nuclear Information System (INIS)

    the extraction of scores of radioresistance, which displayed significant correlations with the estimated parameters of the regression models. Undoubtedly, LQ regression is a robust method for the analysis of clonogenic survival data. Nevertheless, alternative approaches including non-linear regression and multivariate techniques such as cluster analysis and principal component analysis represent versatile tools for the extraction of parameters and/or scores of the cellular response towards ionizing irradiation with a more intuitive biological interpretation. The latter are highly informative for correlation analyses with other types of data, including functional genomics data that are increasingly beinggenerated

  18. Analysis of the dynamic response improvement of a turbocharged diesel engine driven alternating current generating set

    International Nuclear Information System (INIS)

    Reliability of electric supply systems is among the most required necessities of modern society. Turbocharged diesel engine driven alternating current generating sets are often used to prevent electric black outs and/or as prime electric energy suppliers. It is well known that turbocharged diesel engines suffer from an inadequate response to a sudden load increase, this being a consequence of the nature of the energy exchange between the engine and the turbocharger. The dynamic response of turbocharged diesel engines could be improved by electric assisting systems, either by direct energy supply with an integrated starter-generator-booster (ISG) mounted on the engine flywheel, or by an indirect energy supply with an electrically assisted turbocharger. An experimentally verified zero dimensional computer simulation method was used for the analysis of both types of electrical assistance. The paper offers an analysis of the interaction between a turbocharged diesel engine and different electric assisting systems, as well as the requirements for the supporting electric motors that could improve the dynamic response of a diesel engine while driving an AC generating set. When performance class compliance is a concern, it is evident that an integrated starter-generator-booster outperforms an electrically assisted turbocharger for the investigated generating set. However, the electric energy consumption and frequency recovery times are smaller when an electrically assisted turbocharger is applied

  19. An Alternative Methodological Approach for Cost-Effectiveness Analysis and Decision Making in Genomic Medicine.

    Science.gov (United States)

    Fragoulakis, Vasilios; Mitropoulou, Christina; van Schaik, Ron H; Maniadakis, Nikolaos; Patrinos, George P

    2016-05-01

    Genomic Medicine aims to improve therapeutic interventions and diagnostics, the quality of life of patients, but also to rationalize healthcare costs. To reach this goal, careful assessment and identification of evidence gaps for public health genomics priorities are required so that a more efficient healthcare environment is created. Here, we propose a public health genomics-driven approach to adjust the classical healthcare decision making process with an alternative methodological approach of cost-effectiveness analysis, which is particularly helpful for genomic medicine interventions. By combining classical cost-effectiveness analysis with budget constraints, social preferences, and patient ethics, we demonstrate the application of this model, the Genome Economics Model (GEM), based on a previously reported genome-guided intervention from a developing country environment. The model and the attendant rationale provide a practical guide by which all major healthcare stakeholders could ensure the sustainability of funding for genome-guided interventions, their adoption and coverage by health insurance funds, and prioritization of Genomic Medicine research, development, and innovation, given the restriction of budgets, particularly in developing countries and low-income healthcare settings in developed countries. The implications of the GEM for the policy makers interested in Genomic Medicine and new health technology and innovation assessment are also discussed. PMID:27096406

  20. High Altitude Long Endurance UAV Analysis of Alternatives and Technology Requirements Development

    Science.gov (United States)

    Nickol, Craig L.; Guynn, Mark D.; Kohout, Lisa L.; Ozoroski, Thomas A.

    2007-01-01

    An Analysis of Alternatives and a Technology Requirements Study were conducted for two mission areas utilizing various types of High Altitude Long Endurance (HALE) Unmanned Aerial Vehicles (UAV). A hurricane science mission and a communications relay mission provided air vehicle requirements which were used to derive sixteen potential HALE UAV configurations, including heavier-than-air (HTA) and lighter-than-air (LTA) concepts with both consumable fuel and solar regenerative propulsion systems. A HTA diesel-fueled wing-body-tail configuration emerged as the preferred concept given near-term technology constraints. The cost effectiveness analysis showed that simply maximizing vehicle endurance can be a sub-optimum system solution. In addition, the HTA solar regenerative configuration was utilized to perform both a mission requirements study and a technology development study. Given near-term technology constraints, the solar regenerative powered vehicle was limited to operations during the long days and short nights at higher latitudes during the summer months. Technology improvements are required in energy storage system specific energy and solar cell efficiency, along with airframe drag and mass reductions to enable the solar regenerative vehicle to meet the full mission requirements.

  1. An analysis of news media coverage of complementary and alternative medicine.

    Directory of Open Access Journals (Sweden)

    Billie Bonevski

    Full Text Available BACKGROUND: To examine the accuracy and adequacy of lay media news stories about complementary and alternative medicines and therapies. METHODOLOGY/PRINCIPAL FINDINGS: A descriptive analysis of news stories about complementary and alternative medicine (CAM in the Australian media using a national medical news monitoring website, mediadoctor.org.au. Each story was rated against 10 criteria by two individuals. Consensus scores of 222 news articles reporting therapeutic claims about complementary medicines posted on mediadoctor.org.au between 1 January 2004 and 1 September 2007 were calculated. The overall rating score for 222 CAM articles was 50% (95% CI 47% to 53%. There was a statistically significant (F = 3.68, p = 0.006 difference in cumulative mean scores according to type of therapy: biologically based practices (54%, 95% CI 50% to 58%; manipulative body based practices (46%, 95% CI 39% to 54%, whole medical systems (45%, 95% CI 32% to 58%, mind body medicine (41%, 95% CI 31% to 50% and energy medicine (33%, 95% CI 11% to 55%. There was a statistically significant difference in cumulative mean scores (F = 3.72, p = 0.0001 according to the clinical outcome of interest with stories about cancer treatments (62%, 95% CI 54% to 70% scoring highest and stories about treatments for children's behavioural and mental health concerns scoring lowest (31%, 95% CI 19% to 43%. Significant differences were also found in scores between media outlets. CONCLUSIONS/SIGNIFICANCE: There is substantial variability in news reporting practices about CAM. Overall, although they may be improving, the scores remain generally low. It appears that much of the information the public receives about CAM is inaccurate or incomplete.

  2. Multi-Criteria Analysis of Alternative Energy Supply Solutions to Public Nearly Zero Energy Buildings

    OpenAIRE

    Giedrius Šiupšinskas; Solveiga Adomėnaitė

    2013-01-01

    The article analyzes energy supply alternatives for modernised public nearly zero energy buildings. The paper examines alternative energy production systems such as heat pumps (air-water and ground-water), solar collectors, adsorption cooling, biomass boiler, solar photovoltaic, wind turbines and combinations of these systems. The simulation of the analysed building energy demand for different energy production alternatives has been performed using TRNSYS modelling software. In order to deter...

  3. Alternative splicing and trans-splicing events revealed by analysis of the Bombyx mori transcriptome

    OpenAIRE

    Shao, Wei; Zhao, Qiong-Yi; Wang, Xiu-Ye; Xu, Xin-Yan; Tang, Qing; Li, Muwang; Li, Xuan; Xu, Yong-Zhen

    2012-01-01

    Alternative splicing and trans-splicing events have not been systematically studied in the silkworm Bombyx mori. Here, the silkworm transcriptome was analyzed by RNA-seq. The authors identified 320 novel genes, modified 1140 gene models, and found thousands of alternative splicing and 58 trans-splicing events. Studies of three SR proteins show that both their alternative splicing patterns and mRNA products are conserved from insect to human, and one isoform of Srsf6 with a retained intron is ...

  4. Cost benefit analysis of remediation alternatives for controlling the flux of strontium-90 into the Columbia River

    International Nuclear Information System (INIS)

    The release of large volumes of water to waste disposal cribs at the Hanford Site's 100-N Area caused contaminants, principally strontium-90, to be carried toward the Columbia River through the groundwater. Since shutdown of the N Reactor, these releases have been discontinued, although small water flows continue to be discharged to the 1325-N crib. Most of the contamination which is now transported to the river is occurring as a result of the natural groundwater movement. The contaminated groundwater at N Springs flows into the river through seeps and springs along the river's edge. An expedited response action (ERA) has been proposed to eliminate or restrict the flux of strontium-90 into the river. A cost benefit analysis of potential remedial alternatives was completed that recommends the alternative which best meets given selection criteria prescribed by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). The methodology used for evaluation, cost analysis, and alternative recommendation is the engineering evaluation/cost analysis (EE/CA). Complete remediation of the contaminated groundwater beneath 100-N Area was not a principal objective of the analysis. The objective of the cost benefit analysis was to identify a remedial alternative that optimizes the degree of benefit produced for the costs incurred

  5. Expression microarray analysis reveals alternative splicing of LAMA3 and DST genes in head and neck squamous cell carcinoma.

    Directory of Open Access Journals (Sweden)

    Ryan Li

    Full Text Available Prior studies have demonstrated tumor-specific alternative splicing events in various solid tumor types. The role of alternative splicing in the development and progression of head and neck squamous cell carcinoma (HNSCC is unclear. Our study queried exon-level expression to implicate splice variants in HNSCC tumors.We performed a comparative genome-wide analysis of 44 HNSCC tumors and 25 uvulopalatopharyngoplasty (UPPP tissue samples at an exon expression level. In our comparison we ranked genes based upon a novel score-the Maximum-Minimum Exon Score (MMES--designed to predict the likelihood of an alternative splicing event occurring. We validated predicted alternative splicing events using quantitative RT-PCR on an independent cohort.After MMES scoring of 17,422 genes, the top 900 genes with the highest scores underwent additional manual inspection of expression patterns in a graphical analysis. The genes LAMA3, DST, VEGFC, SDHA, RASIP1, and TP63 were selected for further validation studies because of a high frequency of alternative splicing suggested in our graphical analysis, and literature review showing their biological relevance and known splicing patterns. We confirmed TP63 as having dominant expression of the short DeltaNp63 isoform in HNSCC tumor samples, consistent with prior reports. Two of the six genes (LAMA3 and DST validated by quantitative RT-PCR for tumor-specific alternative splicing events (Student's t test, P<0.001.Alternative splicing events of oncologically relevant proteins occur in HNSCC. The number of genes expressing tumor-specific splice variants needs further elucidation, as does the functional significance of selective isoform expression.

  6. An alternate method for extracting DNA from environmentally challenged teeth for improved DNA analysis.

    Science.gov (United States)

    Hughes-Stamm, Sheree; Warnke, Frauke; van Daal, Angela

    2016-01-01

    A grinding-free method to extract DNA from teeth via a direct minimal-invasive retrograde approach to the pulp cavity and dentine was compared to a standard grinding/pulverisation method. This alternate method uses endodontic dental files to access the root canals and pulp cavity for tissue and dentine harvest via the apical end of the roots and avoids mechanical damage to the crown and root morphology. In contrast, other methods require pulverisation of the whole root or tooth, transection or destruction of the occlusal surface to gain access to the DNA in the root canals and pulp chamber. This study compared two methods for preparing dentine powder from the roots of environmentally challenged teeth for forensic DNA analysis. We found that although the filing method was more laborious, and produced less dentine powder, the amount of amplifiable DNA per milligram of powder was substantially higher with the filing method compared to grinding the entire root. In addition, the number of short tandem repeat (STR) alleles detected and the peak height ratios of the STR profiles were notably higher. Although several other methods of extracting DNA-rich tissue from the pulp chamber of teeth have previously been reported, the method presented in this study is minimally invasive, thereby allowing the preservation of tooth and crown morphology. PMID:26832373

  7. Analysis of A-phase transitions during the cyclic alternating pattern under normal sleep.

    Science.gov (United States)

    Mendez, Martin Oswaldo; Chouvarda, Ioanna; Alba, Alfonso; Bianchi, Anna Maria; Grassi, Andrea; Arce-Santana, Edgar; Milioli, Guilia; Terzano, Mario Giovanni; Parrino, Liborio

    2016-01-01

    An analysis of the EEG signal during the B-phase and A-phases transitions of the cyclic alternating pattern (CAP) during sleep is presented. CAP is a sleep phenomenon composed by consecutive sequences of A-phases (each A-phase could belong to a possible group A1, A2 or A3) observed during the non-REM sleep. Each A-phase is separated by a B-phase which has the basal frequency of the EEG during a specific sleep stage. The patterns formed by these sequences reflect the sleep instability and consequently help to understand the sleep process. Ten recordings from healthy good sleepers were included in this study. The current study investigates complexity, statistical and frequency signal properties of electroencephalography (EEG) recordings at the transitions: B-phase-A-phase. In addition, classification between the onset-offset of the A-phases and B-phase was carried out with a kNN classifier. The results showed that EEG signal presents significant differences (p EEG oscillations during sleep present an over-imposed coordination for a few seconds due to the A-phases. The main characteristics for automatic separation between the onset-offset A-phase and the B-phase are the energy at the different frequency bands. PMID:26253282

  8. ALTERNATIVES OF MACCS2 IN LANL DISPERSION ANALYSIS FOR ONSITE AND OFFSITE DOSES

    Energy Technology Data Exchange (ETDEWEB)

    Wang, John HC [Los Alamos National Laboratory

    2012-05-01

    In modeling atmospheric dispersion to determine accidental release of radiological material, one of the common statistical analysis tools used at Los Alamos National Laboratory (LANL) is MELCOR Accident Consequence Code System, Version 2 (MACCS2). MACCS2, however, has some limitations and shortfalls for both onsite and offsite applications. Alternative computer codes, which could provide more realistic calculations, are being investigated for use at LANL. In the Yucca Mountain Project (YMP), the suitability of MACCS2 for the calculation of onsite worker doses was a concern; therefore, ARCON96 was chosen to replace MACCS2. YMP's use of ARCON96 provided results which clearly demonstrated the program's merit for onsite worker safety analyses in a wide range of complex configurations and scenarios. For offsite public exposures, the conservatism of MACCS2 on the treatment of turbulence phenomena at LANL is examined in this paper. The results show a factor of at least two conservatism in calculated public doses. The new EPA air quality model, AERMOD, which implements advanced meteorological turbulence calculations, is a good candidate for LANL applications to provide more confidence in the accuracy of offsite public dose projections.

  9. Thermodynamic analysis of SOFC (solid oxide fuel cell)–Stirling hybrid plants using alternative fuels

    International Nuclear Information System (INIS)

    A novel hybrid power system (∼10 kW) for an average family home is proposed. The system investigated contains a solid oxide fuel cell (SOFC) on top of a Stirling engine. The off-gases produced in the SOFC cycle are fed to a bottoming Stirling engine, at which additional power is generated. Simulations of the proposed system were conducted using different fuels, which should facilitate the use of a variety of fuels depending on availability. Here, the results for natural gas (NG), ammonia, di-methyl ether (DME), methanol and ethanol are presented and analyzed. The system behavior is further investigated by comparing the effects of key factors, such as the utilization factor and the operating conditions under which these fuels are used. Moreover, the effect of using a methanator on the plant efficiency is also studied. The combined system improves the overall electrical efficiency relative to that of a stand-alone Stirling engine or SOFC plant. For the combined SOFC and Stirling configuration, the overall power production was increased by approximately 10% compared to that of a stand-alone SOFC plant. System efficiencies of approximately 60% are achieved, which is remarkable for such small plant sizes. Additionally, heat is also produced to heat the family home when necessary. - Highlights: • Integrating a solid oxide fuel with a Stirling engine • Design of multi-fuel hybrid plants • Plants running on alternative fuels; natural gas, methanol, ethanol, DME and ammonia • Thermodynamic analysis of hybrid SOFC–Stirling engine plants

  10. Neutron activation analysis of alternative phosphate rocks used in animal nutrition

    International Nuclear Information System (INIS)

    Since 1980's, Bovine Sponghiform Encephalophaty has insidiously created a fierce battleground between farmers, scientists, environmentalists and consumers. The use of meat and bone meals is currently prohibited in ruminant feeds throughout the world. Some inorganic sources offer the combination of high phosphorus content and acceptable animal digestibility make them options as supplemental phosphorus, for instance phosphate rocks, general term applied to minerals valued chiefly for their phosphorus content. However, phosphate rocks are long been known containing hazardous elements, make them sometimes unsuitable for animal nutrition. Neutron Activation Analysis has been supportive to the mineral evaluation of alternative phosphate rocks. This evaluation is subject of on-going doctoral thesis which has been carried-out by the main author. The NAA method has been very efficient due to its highly sensitive and multi-elemental nature. In this paper results of Vanadium content from three different phosphate rocks are presented. Their values have been pointed out that Brazilian phosphate rocks present hazardous elements at the same levels of phosphate rocks from some countries of Africa, North America and Middle East, data from our study (Brazilian data) and FAO - Food and Agriculture Organization (others countries). (author)

  11. Well-to-wheels life-cycle analysis of alternative fuels and vehicle technologies in China

    International Nuclear Information System (INIS)

    A well-to-wheels life cycle analysis on total energy consumptions and greenhouse-gas (GHG) emissions for alternative fuels and accompanying vehicle technologies has been carried out for the base year 2010 and projected to 2020 based on data gathered and estimates developed for China. The fuels considered include gasoline, diesel, natural gas, liquid fuels from coal conversion, methanol, bio-ethanol and biodiesel, electricity and hydrogen. Use of liquid fuels including methanol and Fischer–Tropsch derived from coal will significantly increase GHG emissions relative to use of conventional gasoline. Use of starch-based bio-ethanol will incur a substantial carbon disbenefit because of the present highly inefficient agricultural practice and plant processing in China. Electrification of vehicles via hybrid electric, plug-in hybrid electric (PHEV) and battery electric vehicle technologies offers a progressively improved prospect for the reduction of energy consumption and GHG emission. However, the long-term carbon emission reduction is assured only when the needed electricity is generated by zero- or low-carbon sources, which means that carbon capture and storage is a necessity for fossil-based feedstocks. A PHEV that runs on zero- or low-carbon electricity and cellulosic ethanol may be one of the most attractive fuel-vehicle options in a carbon-constrained world. - Highlights: ► Data and estimates unique to China are used in this analysis. ► Use of starch-based bio-ethanol will incur a substantial carbon disbenefit in China. ► Use of methanol derived from coal will incur even more carbon disbenefit. ► Plug-in-hybrid with cellulosic ethanol and clean electricity may be a viable option.

  12. ANALYSIS OF THE PROSPECTS OF SOLAR ENERGY AND OTHER ALTERNATIVE ENERGY SOURCES IN UKRAINE

    OpenAIRE

    Mogylko, O.

    2010-01-01

    The need to develop an alternative energy sources in Ukraine to increase energy efficiency and energy security it is explained in the article. The international experience of development of solar energy are analyzed. The prospects and other alternative energy sources in Ukraine are defined. The conclusions and recommendations to address the problems are identified.

  13. Alternative splicing in colon, bladder, and prostate cancer identified by exon-array analysis

    DEFF Research Database (Denmark)

    Thorsen, Kasper; Sørensen, Karina D.; Brems-Eskildsen, Anne Sofie;

    2008-01-01

    Alternative splicing enhances proteome diversity and modulates cancer-associated proteins. To identify tissue- and tumor-specific alternative splicing, we used the GeneChip Human Exon 1.0 ST Array to measure whole-genome exon expression in 102 normal and cancer tissue samples of different stages ...

  14. FULL-GENOME ANALYSIS OF ALTERNATIVE SPLICING IN MOUSE LIVER AFTER HEPATOTOXICANT EXPOSURE

    Science.gov (United States)

    Alternative splicing plays a role in determining gene function and protein diversity. We have employed whole genome exon profiling using Affymetrix Mouse Exon 1.0 ST arrays to understand the significance of alternative splicing on a genome-wide scale in response to multiple toxic...

  15. Implementation of exon arrays: alternative splicing during T-cell proliferation as determined by whole genome analysis

    Directory of Open Access Journals (Sweden)

    Whistler Toni

    2010-09-01

    Full Text Available Abstract Background The contribution of alternative splicing and isoform expression to cellular response is emerging as an area of considerable interest, and the newly developed exon arrays allow for systematic study of these processes. We use this pilot study to report on the feasibility of exon array implementation looking to replace the 3' in vitro transcription expression arrays in our laboratory. One of the most widely studied models of cellular response is T-cell activation from exogenous stimulation. Microarray studies have contributed to our understanding of key pathways activated during T-cell stimulation. We use this system to examine whole genome transcription and alternate exon usage events that are regulated during lymphocyte proliferation in an attempt to evaluate the exon arrays. Results Peripheral blood mononuclear cells form healthy donors were activated using phytohemagglutinin, IL2 and ionomycin and harvested at 5 points over a 7 day period. Flow cytometry measured cell cycle events and the Affymetrix exon array platform was used to identify the gene expression and alternate exon usage changes. Gene expression changes were noted in a total of 2105 transcripts, and alternate exon usage identified in 472 transcript clusters. There was an overlap of 263 transcripts which showed both differential expression and alternate exon usage over time. Gene ontology enrichment analysis showed a broader range of biological changes in biological processes for the differentially expressed genes, which include cell cycle, cell division, cell proliferation, chromosome segregation, cell death, component organization and biogenesis and metabolic process ontologies. The alternate exon usage ontological enrichments are in metabolism and component organization and biogenesis. We focus on alternate exon usage changes in the transcripts of the spliceosome complex. The real-time PCR validation rates were 86% for transcript expression and 71% for

  16. Multi-criteria analysis of alternative-fuel buses for public transportation

    International Nuclear Information System (INIS)

    The technological development of buses with new alternative fuels is considered in this paper. Several types of fuels are considered as alternative-fuel modes, i.e., electricity, fuel cell (hydrogen), and methanol. Electric vehicles may be considered the alternative-fuel vehicles with the lowest air pollution. Hybrid electric vehicles provide an alternate mode, at least for the period of improving the technology of electric vehicles. A hybrid electric vehicle is defined as a vehicle with the conventional internal combustion engine and an electric motor as its major sources of power. Experts from different decision-making groups performed the multiple attribute evaluation of alternative vehicles. AHP is applied to determine the relative weights of evaluation criteria. TOPSIS and VIKOR are compared and applied to determine the best compromise alternative fuel mode. The result shows that the hybrid electric bus is the most suitable substitute bus for Taiwan urban areas in the short and median term. But, if the cruising distance of the electric bus extends to an acceptable range, the pure electric bus could be the best alternative

  17. Multi-level multi-criteria analysis of alternative fuels for waste collection vehicles in the United States.

    Science.gov (United States)

    Maimoun, Mousa; Madani, Kaveh; Reinhart, Debra

    2016-04-15

    Historically, the U.S. waste collection fleet was dominated by diesel-fueled waste collection vehicles (WCVs); the growing need for sustainable waste collection has urged decision makers to incorporate economically efficient alternative fuels, while mitigating environmental impacts. The pros and cons of alternative fuels complicate the decisions making process, calling for a comprehensive study that assesses the multiple factors involved. Multi-criteria decision analysis (MCDA) methods allow decision makers to select the best alternatives with respect to selection criteria. In this study, two MCDA methods, Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) and Simple Additive Weighting (SAW), were used to rank fuel alternatives for the U.S. waste collection industry with respect to a multi-level environmental and financial decision matrix. The environmental criteria consisted of life-cycle emissions, tail-pipe emissions, water footprint (WFP), and power density, while the financial criteria comprised of vehicle cost, fuel price, fuel price stability, and fueling station availability. The overall analysis showed that conventional diesel is still the best option, followed by hydraulic-hybrid WCVs, landfill gas (LFG) sourced natural gas, fossil natural gas, and biodiesel. The elimination of the WFP and power density criteria from the environmental criteria ranked biodiesel 100 (BD100) as an environmentally better alternative compared to other fossil fuels (diesel and natural gas). This result showed that considering the WFP and power density as environmental criteria can make a difference in the decision process. The elimination of the fueling station and fuel price stability criteria from the decision matrix ranked fossil natural gas second after LFG-sourced natural gas. This scenario was found to represent the status quo of the waste collection industry. A sensitivity analysis for the status quo scenario showed the overall ranking of diesel and

  18. Milk fat globule is an alternative to mammary epithelial cells for gene expression analysis in buffalo.

    Science.gov (United States)

    Chen, Qiuming; Wu, Yanjun; Zhang, Mingyuan; Xu, Wenwen; Guo, Xiaoping; Yan, Xueyu; Deng, Haiying; Jiang, Qinyang; Yang, Xiurong; Lan, Ganqiu; Guo, Yafen; Qin, Guangsheng; Jiang, Hesheng

    2016-05-01

    Owing to the difficulty in obtaining mammary gland tissue from lactating animals, it is difficult to test the expression levels of genes in mammary gland. The aim of the current study was to identify if milk fat globule (MFG) in buffalo milk was an alternative to mammary gland (MG) and milk somatic cell (MSC) for gene expression analysis. Six buffalos in late lactation were selected to collect MFG and MSC, and then MG was obtained by surgery. MFG was stained with acridine orange to successfully visualise RNA and several cytoplasmic crescents in MFG. The total RNA in MFG was successfully isolated and the integrity was assessed by agarose gel electrophoresis. We analysed the cellular components in MFG, MG and MSC through testing the expression of cell-specific genes by qRT-PCR. The results showed that adipocyte-specific gene (AdipoQ) and leucocyte-specific genes (CD43, CSF1 and IL1α) in MFG were not detected, whereas epithelial cell marker genes (Keratin 8 and Keratin 18) in MFG were higher than in MSC and lower than in MG, fibroblast marker gene (vimentin) in MFG was significantly lower than in MG and MSC, milk protein genes (LALBA, BLG and CSN2) and milk fat synthesis-related genes (ACC, BTN1A1, FABP3 and FAS) in MFG were higher than in MG and MSC. In conclusion, the total RNA in MFG mainly derives from mammary epithelial cells and can be used to study the functional gene expression of mammary epithelial cells. PMID:27032540

  19. Molecular analysis of human argininosuccinate lyase: Mutant characterization and alternative splicing of the coding region

    International Nuclear Information System (INIS)

    Argininosuccinic acid lyase (ASAL) deficiency is a clinically heterogeneous autosomal recessive urea cycle disorder. The authors previously established by complementation analysis that 29 ASAL-deficient patients have heterogeneous mutations in a single gene. To prove that the ASAL structural gene is the affected locus, they sequenced polymerase chain reaction-amplified ASAL cDNA of a representative mutant from the single complementation group. Fibroblast strain 944 from a late-onset patient who was the product of a consanguineous mating, had only a single base-pair change in the coding region, a C-283→ T transition at a CpG dinucleotide in exon 3. This substitution converts Arg-95 to Cys (R95C), occurs in a stretch of 13 residues that is identical in yeast and human ASAL, and was present in both of the patient's alleles but not in 14 other mutant or 10 normal alleles. They observed that amplified cDNA from mutant 944 and normal cells (liver, keratinocytes, lymphoblasts, and fibroblasts) contained, in addition to the expected 5' 513-base-pair band, a prominent 318-base-pair ASAL band formed by the splicing of exon 2 from the transcript. The short transcript maintains the ASAL reading frame but removes Lys-51, a residue that may be essential for catalysis, since it binds the argininosuccinate substrate. They conclude (i) that the identification of the R95C mutation in strain 944 demonstrates that virtually all ASAL deficiency results from defects in the ASAL structural gene and (ii) that minor alternative splicing of the coding region occurs at the ASAL locus

  20. Remote-Handled Low-Level Waste Disposal Project Alternatives Analysis

    Energy Technology Data Exchange (ETDEWEB)

    David Duncan

    2009-10-01

    This report identifies, evaluates, and compares alternatives for meeting the U.S. Department of Energy’s mission need for management of remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Each alternative identified in the Mission Need Statement for the Remote-Handled Low-Level Waste Treatment Project is described and evaluated for capability to fulfill the mission need. Alternatives that could meet the mission need are further evaluated and compared using criteria of cost, risk, complexity, stakeholder values, and regulatory compliance. The alternative for disposal of remote-handled low-level waste that has the highest confidence of meeting the mission need and represents best value to the government is to build a new disposal facility at the Idaho National Laboratory Site.

  1. Remote-Handled Low-Level Waste Disposal Project Alternatives Analysis

    Energy Technology Data Exchange (ETDEWEB)

    David Duncan

    2011-03-01

    This report identifies, evaluates, and compares alternatives for meeting the U.S. Department of Energy’s mission need for management of remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Each alternative identified in the Mission Need Statement for the Remote-Handled Low-Level Waste Treatment Project is described and evaluated for capability to fulfill the mission need. Alternatives that could meet the mission need are further evaluated and compared using criteria of cost, risk, complexity, stakeholder values, and regulatory compliance. The alternative for disposal of remote-handled low-level waste that has the highest confidence of meeting the mission need and represents best value to the government is to build a new disposal facility at the Idaho National Laboratory Site.

  2. Remote-Handled Low-Level Waste Disposal Project Alternatives Analysis

    Energy Technology Data Exchange (ETDEWEB)

    David Duncan

    2011-04-01

    This report identifies, evaluates, and compares alternatives for meeting the U.S. Department of Energy’s mission need for management of remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Each alternative identified in the Mission Need Statement for the Remote-Handled Low-Level Waste Treatment Project is described and evaluated for capability to fulfill the mission need. Alternatives that could meet the mission need are further evaluated and compared using criteria of cost, risk, complexity, stakeholder values, and regulatory compliance. The alternative for disposal of remote-handled low-level waste that has the highest confidence of meeting the mission need and represents best value to the government is to build a new disposal facility at the Idaho National Laboratory Site.

  3. Remote-Handled Low-Level Waste Disposal Project Alternatives Analysis

    Energy Technology Data Exchange (ETDEWEB)

    David Duncan

    2010-06-01

    This report identifies, evaluates, and compares alternatives for meeting the U.S. Department of Energy’s mission need for management of remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Each alternative identified in the Mission Need Statement for the Remote-Handled Low-Level Waste Treatment Project is described and evaluated for capability to fulfill the mission need. Alternatives that could meet the mission need are further evaluated and compared using criteria of cost, risk, complexity, stakeholder values, and regulatory compliance. The alternative for disposal of remote-handled low-level waste that has the highest confidence of meeting the mission need and represents best value to the government is to build a new disposal facility at the Idaho National Laboratory Site.

  4. MARAS - a computer code for semi-Markov reliability analysis of alternating systems

    International Nuclear Information System (INIS)

    It is now recognized that current testing and maintenance requirements invoke too many inadvertent reactor trips and that operating staff must devote significant amount of time and effort to comply with the requirements. With this recognition, the value and the impact of the proposed changes in the allowed outage time (AOT) and surveillance test interval(STI) are evaluated for the alternating system. Because of the testing and AOT requirements, the alternating system exhibits semi-Markovian characteristics which change states in accordance with a Markov chain but take a nonexponentially distributed amount of time between changes. It is observed from the results that there is an optimal point that gives lowest core damage probability and that the optimal point depends on input parameters. With these results, we can conclude that the methodology developed in this study can be applied to the existing alternating systems to evaluate accurately the various alternatives in the technical specifications

  5. The Efficiency of the Treasury Bill Futures Market: An Analysis of Alternative Specifications

    OpenAIRE

    Vignola, Anthony; Dale, Charles

    1980-01-01

    Until the existence of financial futures, testing the determinants and the informational content of futures market prices has been difficult because of the vagaries associated with commodity markets. In the case of Treasury bill futures, the existence of an active secondary market and the resulting term structure of interest rates enables one to test alternative hypotheses about the prices of futures contracts. This study compares two alternative specifications of equilibrium futures prices...

  6. Bibliometric analysis of scientific production on augmentantive and alternative communication - a research on virtual health library

    OpenAIRE

    Candice Lima Moreschi; Suzelei Faria Bello; Maria Cristina Piumbato Innocentini Hayashi

    2013-01-01

    Purpose: To identify the papers whose aim was to study the Alternative Communication issue, of the Virtual Health Library (VHL) database from 1981 to 2008. Methodology: documentary research, qualitative and quantitative exploratory descriptive level, that involves the following steps: 1) selection of the descriptor with terminology defined in the Health Science Descriptors (DeCS); 2) survey of literature production about the topic in the VHL Alternative Communication; 3) list the indicators a...

  7. Transcriptome Bioinformatical Analysis of Vertebrate Stages of Schistosoma japonicum Reveals Alternative Splicing Events

    OpenAIRE

    Xinye Wang; Xindong Xu; Xingyu Lu; Yuanbin Zhang; Weiqing Pan

    2015-01-01

    Alternative splicing is a molecular process that contributes greatly to the diversification of proteome and to gene functions. Understanding the mechanisms of stage-specific alternative splicing can provide a better understanding of the development of eukaryotes and the functions of different genes. Schistosoma japonicum is an infectious blood-dwelling trematode with a complex lifecycle that causes the tropical disease schistosomiasis. In this study, we analyzed the transcriptome of Schistoso...

  8. Deterministic and stochastic analysis of alternative climate targets under differentiated cooperation regimes

    International Nuclear Information System (INIS)

    This article analyzes the feasibility of attaining a variety of climate targets during the 21st century, under alternative cooperation regimes by groups of countries. Five climate targets of increasing severity are analyzed, following the EMF-22 experiment. Each target is attempted under two cooperation regimes, a First Best scenario where all countries fully cooperate from 2012 on, and a Second Best scenario where the World is partitioned into three groups, and each group of countries enters the cooperation at a different date, and implement emission abatement actions in a progressive manner, once in the coalition. The resulting ten combinations are simulated via the ETSAP-TIAM technology based, integrated assessment model. In addition to the 10 separate case analyses, the article proposes a probabilistic treatment of three targets under the First Best scenario, and shows that the three forcing targets may in fact be interpreted as a single target on global temperature change, while assuming that the climate sensitivity Cs is uncertain. It is shown that such an interpretation is possible only if the probability distribution of Cs is carefully chosen. The analysis of the results shows that the lowest forcing level is unattainable unless immediate coordinated action is undertaken by all countries, and even so only at a high global cost. The middle and the high forcing levels are feasible at affordable global costs, even under the Second Best scenario. Another original contribution of this article is to explain why certain combinations of technological choices are made by the model, and in particular why the climate target clearly supersedes the usually accepted objective of improving energy efficiency. The analysis shows that under some climate targets, it is not optimal to improve energy efficiency, but rather to take advantage of certain technologies that help to reach the climate objective, but that happen to be less energy efficient than even the technologies in

  9. How robust is a robust policy? A comparative analysis of alternative robustness metrics for supporting robust decision analysis.

    Science.gov (United States)

    Kwakkel, Jan; Haasnoot, Marjolijn

    2015-04-01

    In response to climate and socio-economic change, in various policy domains there is increasingly a call for robust plans or policies. That is, plans or policies that performs well in a very large range of plausible futures. In the literature, a wide range of alternative robustness metrics can be found. The relative merit of these alternative conceptualizations of robustness has, however, received less attention. Evidently, different robustness metrics can result in different plans or policies being adopted. This paper investigates the consequences of several robustness metrics on decision making, illustrated here by the design of a flood risk management plan. A fictitious case, inspired by a river reach in the Netherlands is used. The performance of this system in terms of casualties, damages, and costs for flood and damage mitigation actions is explored using a time horizon of 100 years, and accounting for uncertainties pertaining to climate change and land use change. A set of candidate policy options is specified up front. This set of options includes dike raising, dike strengthening, creating more space for the river, and flood proof building and evacuation options. The overarching aim is to design an effective flood risk mitigation strategy that is designed from the outset to be adapted over time in response to how the future actually unfolds. To this end, the plan will be based on the dynamic adaptive policy pathway approach (Haasnoot, Kwakkel et al. 2013) being used in the Dutch Delta Program. The policy problem is formulated as a multi-objective robust optimization problem (Kwakkel, Haasnoot et al. 2014). We solve the multi-objective robust optimization problem using several alternative robustness metrics, including both satisficing robustness metrics and regret based robustness metrics. Satisficing robustness metrics focus on the performance of candidate plans across a large ensemble of plausible futures. Regret based robustness metrics compare the

  10. The analysis of covariance and alternatives statistical methods for experiments, quasi-experiments, and single-case studies

    CERN Document Server

    Huitema, Bradley

    2011-01-01

    A complete guide to cutting-edge techniques and best practices for applying covariance analysis methods The Second Edition of Analysis of Covariance and Alternatives sheds new light on its topic, offering in-depth discussions of underlying assumptions, comprehensive interpretations of results, and comparisons of distinct approaches. The book has been extensively revised and updated to feature an in-depth review of prerequisites and the latest developments in the field. The author begins with a discussion of essential topics relating to experimental design and analysis

  11. Semi-Markov reliability analysis of alternating systems in a nuclear power plant

    International Nuclear Information System (INIS)

    Nuclear power plant operations that follow current testing and maintenance requirements sometimes result in inadvertent reactor trips, and operating staffs devote a significant amount of time and effort in complying with these requirements. Significant benefits could result from changes in current technical specifications. In this paper the benefits and impacts of changes in allowed outage times (AOTs) and surveillance test intervals (STIs) are evaluated for an alternative system that consists of multiple trains and whose operation is alternated train by train. because of testing and AOT requirements, the alternating system exhibits semi-Markovian characteristics that change states in accordance with a Markov process but take an arbitrarily distributed amount of time between changes. The state probabilities are quantified by memorizing the necessary number of past state probabilities. Two measures of plant performance, namely, core damage probability and plant unavailability (reactor downtime), were calculated for the evaluation of AOT and STI. Results indicate that there is an optimal point that gives the lowest core damage probability and that the methodology developed in this study can be applied to existing alternating systems to evaluate accurately the various alternatives in the technical specifications

  12. Electrical signature analysis applications for non-intrusive automotive alternator diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Ayers, C.W.

    1996-03-01

    Automotive alternators are designed to supply power for automobile engine ignition systems as well as charge the storage battery. This product is used in a large market where consumers are concerned with acoustic noise and vibration that comes from the unit. as well as overall quality and dependability. Alternators and generators in general are used in industries other than automotive, such as transportation and airline industries and in military applications. Their manufacturers are interested in pursuing state-of-the-art methods to achieve higher quality and reduced costs. Preliminary investigations of non-intrusive diagnostic techniques utilizing the inherent voltage signals of alternators have been performed with promising results. These techniques are based on time and frequency domain analyses of specially conditioned signals taken from several alternators under various test conditions. This paper discusses investigations that show correlations of the alternator output voltage to airborne noise production. In addition these signals provide insight into internal magnetic characteristics that relate to design and/or assembly problems.

  13. Cost and operational effectiveness analysis of alternative force structures for fulfillment of the United States Marine Corps operational support airlift and search and rescue missions

    OpenAIRE

    Chase, Eric T.

    2000-01-01

    This thesis provides a preliminary cost and operational effectiveness analysis of alternative force structures for the United States Marine Corps operational support airlift and search and rescue missions. The four alternative force structures include C-12s and CH-46Es, C-35s and CH-46Es and HV-609s. Lifecycle cost analysis of the alternative force structures using Crystal Bali forecasting provides a 90% upper confidence level lifecycle cost estimate that identifies a mix of C-35s for operati...

  14. Alternatives Analysis Amchitka Island Mud Pit Cap Repair, Amchitka, Alaska January 2016

    Energy Technology Data Exchange (ETDEWEB)

    Darr, Paul S. [US Department of Energy, Washington, DC (United States). Office of Legacy Management

    2016-01-01

    The U.S. Department of Energy (DOE) Office of Legacy Management (LM) manages the Nevada Offsites program, which includes a series of reclaimed drilling mud impoundments on Amchitka Island, Alaska (Figure 1). Navarro Research and Engineering, Inc. is the Legacy Management Support contractor (the Contractor) for LM. The Contractor has procured Tetra Tech, Inc. to provide engineering support to the Amchitka mud pit reclamation project. The mud pit caps were damaged during a 7.9-magnitude earthquake that occurred in 2014. The goals of the current project are to investigate conditions at the mud pit impoundments, identify feasible alternatives for repair of the cover systems and the contents, and estimate relative costs of repair alternatives. This report presents descriptions of the sites and past investigations, existing conditions, summaries of various repair/mitigation alternatives, and direct, unburdened, order-of-magnitude (-15% to +50%) associated costs.

  15. How to proceed with competing alternative energy technologies. A real options analysis

    International Nuclear Information System (INIS)

    Concerns about CO2 emissions create incentives for the development and deployment of energy technologies that do not use fossil fuels. Indeed, such technologies would provide tangible benefits in terms of avoided fossil-fuel costs, which are likely to increase as restrictions on CO2 emissions are imposed. However, a number of challenges need to be overcome prior to market deployment, and the commercialisation of alternative energy technologies may require a staged approach given price and technical risk. We analyse how a firm may proceed with staged commercialisation and deployment of competing alternative energy technologies. An unconventional new alternative technology is one possibility, where one could undertake cost-reducing production enhancement measures as an intermediate step prior to deployment. By contrast, the firm could choose to deploy a smaller-scale existing renewable energy technology, and, using the real options framework, we compare the two projects to provide managerial implications on how one might proceed. (author)

  16. Analysis of different alternatives for a reactor aimed to produce Co60. Neutronic part

    International Nuclear Information System (INIS)

    Different alternatives are presented for a reactor aimed to produce radioisotopes with a low enrichment fuel element geometrically equal to those of low enrichment. Different alternatives are presented which essentially differ in the core's configuration, fuel management and 'meat' fuel material: U3O8, U3Si or U3Si2 in aluminium matrix. Fluxes at different irradiation positions and power full peak factors are described for each case. The main aspects to be taken into account for cobalt irradiation and the method to be followed to measure the reactor as a function of a required production are presented. (Author)

  17. Digital-computer program for design analysis of salient, wound pole alternators

    Science.gov (United States)

    Repas, D. S.

    1973-01-01

    A digital computer program for analyzing the electromagnetic design of salient, wound pole alternators is presented. The program, which is written in FORTRAN 4, calculates the open-circuit saturation curve, the field-current requirements at rated voltage for various loads and losses, efficiency, reactances, time constants, and weights. The methods used to calculate some of these items are presented or appropriate references are cited. Instructions for using the program and typical program input and output for an alternator design are given, and an alphabetical list of most FORTRAN symbols and the complete program listing with flow charts are included.

  18. Electric Demand Analysis of the Tunisian Network: Trends and Short Term Photovoltaic Implementation with Alternatives Prospects and Technologies

    OpenAIRE

    J. Bouattour; A. Mami; L. Pierrat; Y. Weslati

    2014-01-01

    The main objective of this study is to analyze the system of electric demand in Tunisia and to propose immediate alternative solution of photovoltaic implementation that can be suitable based on available natural solar energy resources in the country to respond to the short Forecast peak demand growth and energy consumptions taking into account financial strain. On the first step, analysis of the situation based on the recent historical data is proposed. In a second step, a solution is consid...

  19. Design of batch operations: Systematic methodology for generation and analysis of sustainable alternatives

    DEFF Research Database (Denmark)

    Carvalho, Ana; Matos, Henrique A.; Gani, Rafiqul

    2010-01-01

    operational, environmental, economical and safety related problems inherent in the process (batch or continuous). Alternatives that are more sustainable, compared to a reference, are generated and evaluated by addressing one or more of the identified problems. A decomposition technique as well as a set of...

  20. An Empirical Analysis of an Alternative Configuration of the Academic Motivation Scale

    Science.gov (United States)

    Smith, Kenneth J.; Davy, Jeanette A.; Rosenberg, Donald L.

    2012-01-01

    The purpose of this study was to examine an alternative configuration of the Academic Motivation Scale (AMS), a psychometric instrument used as a measure of academic motivation in various academic environments. The analyses utilised data from a convenience sample of 2354 business students, broken into two random subsamples of 1177 cases.…

  1. BOOST QUALITY OF ENGINEERING PROJECT SOLUTIONS THROUGH ECONOMIC ANALYSIS AND COMPARING ALTERNATIVES

    Directory of Open Access Journals (Sweden)

    Milan Vukčević

    2008-12-01

    Full Text Available In this paper the principles and applications of money-time relationships are given. Economic profitability of engineering projects, using more methodes is analised. On the bases those methodes, comparing mutually exclusive alternatives of projects was done, because of optimization of decision. The emphasized theoretical states in this paper are applicated.

  2. Studying Effects of Transcranial Alternating Current Stimulation on Hearing and Auditory Scene Analysis

    NARCIS (Netherlands)

    Riecke, Lars

    2016-01-01

    Recent studies have shown that perceptual detection of near-threshold auditory events may depend on the relative timing of the event and ongoing brain oscillations. Furthermore, transcranial alternating current stimulation (tACS), a non-invasive and silent brain stimulation technique, can entrain co

  3. Low-Level Waste Disposal Alternatives Analysis for Low-Level Waste Generated at the Idaho National Laboratory

    International Nuclear Information System (INIS)

    This paper presents the results of a study that identifies and compares on-site and off-site disposal options for the disposal of contact-handled and remote-handled low-level waste generated by the Idaho National Laboratory and its tenants. Potential disposal options are screened for viability by waste type resulting in a short list of options for further consideration. The most credible options are selected after a systematic consideration of cost, schedule constraints, and risk. In order to holistically address the approach for low-level waste disposal, options are compiled into comprehensive disposal schemes, that is, alternative scenarios. Each alternative scenario addresses the disposal path for all low-level waste types over the period of interest. The alternative scenarios are compared and ranked using cost, risk and complexity to arrive at the recommended approach. Schedule alignment with disposal needs is addressed to ensure that all waste types are managed appropriately. The recommended alternative scenario for the disposal of low-level waste based on this analysis is to build a disposal facility at the Idaho National Laboratory Site. (authors)

  4. Benefits and risks of emerging technologies: integrating life cycle assessment and decision analysis to assess lumber treatment alternatives.

    Science.gov (United States)

    Tsang, Michael P; Bates, Matthew E; Madison, Marcus; Linkov, Igor

    2014-10-01

    Assessing the best options among emerging technologies (e.g., new chemicals, nanotechnologies) is complicated because of trade-offs across benefits and risks that are difficult to quantify given limited and fragmented availability of information. This study demonstrates the integration of multicriteria decision analysis (MCDA) and life cycle assessment (LCA) to address technology alternative selection decisions. As a case study, prioritization of six lumber treatment alternatives [micronized copper quaternary (MCQ); alkaline copper quaternary (ACQ); water-borne copper naphthenate (CN); oil-borne copper naphthenate (CNo); water-borne copper quinolate (CQ); and water-borne zinc naphthenate (ZN)] for military use are considered. Multiattribute value theory (MAVT) is used to derive risk and benefit scores. Risk scores are calculated using a cradle-to-gate LCA. Benefit scores are calculated by scoring of cost, durability, and corrosiveness criteria. Three weighting schemes are used, representing Environmental, Military and Balanced stakeholder perspectives. Aggregated scores from all three perspectives show CQ to be the least favorable alterative. MCQ is identified as the most favorable alternative from the Environmental stakeholder perspective. From the Military stakeholder perspective, ZN is determined to be the most favorable alternative, followed closely by MCQ. This type of scoring and ranking of multiple heterogeneous criteria in a systematic and transparent way facilitates better justification of technology selection and regulation. PMID:25209330

  5. Design analysis of fixed-pitch straight-bladed vertical axis wind turbines with an alternative material

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M.; Ting, D.S.K.; Fartaj, A. [Windsor Univ., ON (Canada). Dept. of Mechanical, Automotive and Materials Engineering; Ahmed, F.U. [Lambton College of Applied Arts and Technology, Sarnia, ON (Canada)

    2008-07-01

    Most blades in fixed-pitch straight-bladed vertical axis wind turbine (SB-VAWT) are made of aluminium. However, in order for wind energy to be cost competitive, the blades must be produced at moderate cost. The blades should also last between 20 and 30 years, which is the predicted service life of these mechanically uncomplicated turbomachines. The primary disadvantage of using aluminium alloy for wind turbine application is its poor fatigue properties. Its allowable stress levels in dynamic application also decrease significantly at increasing numbers of cyclic stress applications. For that reason, this study investigated alternative materials for SB-VAWT blades. The properties of the SB-VAWT blade materials were identified in this paper along with prospective materials. Comparisons were then made between the available materials based on their mechanical properties and costs. The most attractive alternative material was then chosen for a detailed design analysis using an analytical tool. The design features of an SB-VAWT with aluminium and pultruded fiberglass reinforced plastic (FRP) blades were then compared using one of the prospective airfoils. The alternative blade material was found to be superior to the conventionally used aluminum. It was concluded that pultruded FRP is a prospective alternative blade material for SB-VAWTs. 9 refs., 2 tabs., 1 fig.

  6. 2-Methoxyethylamine as Co2 absorber alternative for analysis of 14C content in soil and groundwater samples

    International Nuclear Information System (INIS)

    At the hydrology laboratory PATIR-BATAN, 14C analysis using Carbosorb as an absorber of CO2 has been developed and applied to several research activities especially researches related to soil and groundwater. However, at the present time, Packard Co. as a producer of carbosorb is no longer producing carbosorb hence it is hardly found in the market. Therefore, the alternatives of CO2 absorber should be found. 2-Methoxyethylamine is considered to be a good alternative and it is commercially available. The study is intended to elaborate the potential of 2-methoxyethylamine as an alternative absorber to analyze 14C content. Several times of analysis showed that the solution of 2 methoxyethylamine/scintillator at 21 ml is able to absorb 2.61-3.08 g CO2 or equivalent to 0.713 -0.810 g of 14C at saturated temperature of 53oC. At this time, the density of the solutions increased from 0.866 g/ml to around 0.974 g/ml. By three times test, the results of background and standard counting were relatively stable with values 20.36 ± 0.10 cpm and 32.74 ± 0.06 cpm, respectively. Whereas, the results of several samples analysis showed that all the 14C count of soil and groundwater during this study were in between the count of background and standard. This result shows that 2 methoxyethylamine can serve as an alternative of CO2 absorber to determine the age of soil and groundwater samples through their 14C contents. (author)

  7. A genome wide analysis of alternative splicing events during the osteogenic differentiation of human cartilage endplate-derived stem cells.

    Science.gov (United States)

    Shang, Jin; Wang, Honggang; Fan, Xin; Shangguan, Lei; Liu, Huan

    2016-08-01

    Low back pain is a prevalent disease, which leads to suffering and disabilities in a vast number of individuals. Degenerative disc diseases are usually the underlying causes of low back pain. However, the pathogenesis of degenerative disc diseases is highly complex and difficult to determine. Current therapies for degenerative disc diseases are various. In particular, cell-based therapies have proven to be effective and promising. Our research group has previously isolated and identified the cartilage endplate‑derived stem cells. In addition, alternative splicing is a sophisticated regulatory mechanism, which greatly increases cellular complexity and phenotypic diversity of eukaryotic organisms. The present study continued to investigate alternative splicing events in osteogenic differentiation of cartilage endplate‑derived stem cells. An Affymetrix Human Transcriptome Array 2.0 was used to detect splicing changes between the control and differentiated samples. Additionally, molecular function and pathway analysis were also performed. Following rigorous bioinformatics analysis of the data, 3,802 alternatively spliced genes were identified, and 10 of these were selected for validation by reverse transcription‑polymerase chain reaction. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway analysis also revealed numerous enriched GO terms and signaling pathways. To the best of our knowledge, the present study is the first to investigate alternative splicing mechanisms in osteogenic differentiation of stem cells on a genome‑wide scale. The illumination of molecular mechanisms of stem cell osteogenic differentiation may assist the development novel bioengineered methods to treat degenerative disc diseases. PMID:27278552

  8. Clinical outcome research in complementary and alternative medicine: an overview of experimental design and analysis.

    Science.gov (United States)

    Gatchel, R J; Maddrey, A M

    1998-09-01

    This article serves as a primer for those beginning clinical research in complementary and alternative medicine. The authors provide a basic overview of important experimental design and statistical issues, of which clinical researchers in the area of complementary and alternative medicine must be aware when attempting to demonstrate the effectiveness of particular treatment modalities. As the article suggests, science is an inferential process, and experimental investigations can vary greatly in methodological integrity. Key concepts in clinical outcome research such as internal validity, statistical conclusion validity, and the appropriate measurement and operational definitions of outcomes are discussed. New scientific approaches that are evolving because of paradigm shifts in science (e.g., chaos theory) are also reviewed. Suggestions are provided to further develop an understanding of clinical outcome research methodology. PMID:9737030

  9. Thermodynamic analysis of alternative marine fuels for marine gas turbine power plants

    Science.gov (United States)

    El Gohary, Mohamed M.; Ammar, Nader R.

    2016-03-01

    The marine shipping industry faces challenges to reduce engine exhaust emissions and greenhouse gases (GHGs) from ships, and in particular, carbon dioxide. International regulatory bodies such as the International Maritime Organization and National Environmental Agencies of many countries have issued rules and regulations to drastically reduce GHG and emissions emanating from marine sources. This study investigates the possibility of using natural gas and hydrogen as alternative fuels to diesel oil for marine gas turbines and uses a mathematical model to assess the effect of these alternative fuels on gas turbine thermodynamic performance. Results show that since natural gas is categorized as a hydrocarbon fuel, the thermodynamic performance of the gas turbine cycle using natural gas was close to that of the diesel case. However, the gas turbine thermal efficiency was found to be slightly lower for natural gas and hydrogen fuels compared to diesel fuel.

  10. Thermodynamic Analysis of Alternative Marine Fuels for Marine Gas Turbine Power Plants

    Institute of Scientific and Technical Information of China (English)

    Mohamed M El Gohary; Nader R Ammar

    2016-01-01

    The marine shipping industry faces challenges to reduce engine exhaust emissions and greenhouse gases (GHGs) from ships, and in particular, carbon dioxide. International regulatory bodies such as the International Maritime Organization and National Environmental Agencies of many countries have issued rules and regulations to drastically reduce GHG and emissions emanating from marine sources. This study investigates the possibility of using natural gas and hydrogen as alternative fuels to diesel oil for marine gas turbines and uses a mathematical model to assess the effect of these alternative fuels on gas turbine thermodynamic performance. Results show that since natural gas is categorized as a hydrocarbon fuel, the thermodynamic performance of the gas turbine cycle using natural gas was close to that of the diesel case. However, the gas turbine thermal efficiency was found to be slightly lower for natural gas and hydrogen fuels compared to diesel fuel.

  11. How to Proceed with Competing Alternative Energy Technologies: a Real Options Analysis

    OpenAIRE

    Siddiqui, Afzal; Fleten, Stein-Erik

    2008-01-01

    Concerns with CO2 emissions are creating incentives for the development and deployment of energy technologies that do not use fossil fuels. Indeed, such technologies would provide tangible benefits in terms of avoided fossil-fuel costs, which are likely to increase as restrictions on CO2 emissions are imposed. However, there are a number of challenges that need to be overcome, and the current costs of developing new alternative energy technologies would be too high to be handled privately....

  12. Immobilized high-level waste interim storage alternatives generation and analysis and decision report

    International Nuclear Information System (INIS)

    This report presents a study of alternative system architectures to provide onsite interim storage for the immobilized high-level waste produced by the Tank Waste Remediation System (TWRS) privatization vendor. It examines the contract and program changes that have occurred and evaluates their impacts on the baseline immobilized high-level waste (IHLW) interim storage strategy. In addition, this report documents the recommended initial interim storage architecture and implementation path forward

  13. Summary analysis of a Monte Carlo simulation of ecology's statistical guidance and a proposed alternative

    International Nuclear Information System (INIS)

    The State of Washington has recommended a specific statistical test procedure for identifying soil contamination at a potential waste site, referred to here as the State test. An alternative to this test has been presented (DOE/RL 1994), which uses the Wilcoxon Rank Sum, Quantile, and Hot Measurement Comparison tests (WQH). These same tests are recommended by the U.S. Environmental Protection Agency (EPA) to determine if soils from a waste site differ from site-specific, reference-based standards

  14. Alternatives generation and analysis for double-shell tank primary ventilation systems emissions control and monitoring

    Energy Technology Data Exchange (ETDEWEB)

    SEDERBURG, J.P.

    1999-09-30

    This AGA addresses the question: ''What equipment upgrades, operational changes, and/or other actions are required relative to the DST tanks farms' ventilation systems to support retrieval, staging (including feed sampling), and delivery of tank waste to the Phase I private contractor?'' Issues and options for the various components within the ventilation subsystem affect each other. Recommended design requirements are presented and the preferred alternatives are detailed.

  15. Socio-economic impact analysis: Centralia mine fire abatement alternatives. Draft report

    Energy Technology Data Exchange (ETDEWEB)

    1980-11-07

    The overall purpose of information contained in the following text is to document the likely social and economic impacts upon the Borough of Centralia through implementation of various mine fire abatement alternatives. Much of the data presented herein and utilized in preparing conclusions and recommendations have been derived from those individuals whose lives are now, or may eventually be, impacted by the underground mine fire.

  16. Microarray Meta-Analysis of RNA-Binding Protein Functions in Alternative Polyadenylation

    OpenAIRE

    Hu, Wenchao; Liu, Yuting; Yan, Jun

    2014-01-01

    Alternative polyadenylation (APA) is a post-transcriptional mechanism to generate diverse mRNA transcripts with different 3′UTRs from the same gene. In this study, we systematically searched for the APA events with differential expression in public mouse microarray data. Hundreds of genes with over-represented differential APA events and the corresponding experiments were identified. We further revealed that global APA differential expression occurred prevalently in tissues such as brain comp...

  17. Alternatives generation and analysis for double-shell tank primary ventilation systems emissions control and monitoring

    International Nuclear Information System (INIS)

    This AGA addresses the question: ''What equipment upgrades, operational changes, and/or other actions are required relative to the DST tanks farms' ventilation systems to support retrieval, staging (including feed sampling), and delivery of tank waste to the Phase I private contractor?'' Issues and options for the various components within the ventilation subsystem affect each other. Recommended design requirements are presented and the preferred alternatives are detailed

  18. Analysis of Alternative Rework Strategies for Printed Wiring Assembly Manufacturing Systems

    OpenAIRE

    Driels, Morris; Klegka, John S.

    1991-01-01

    This paper presents a model for predicting the cost of test, diagnosis, and rework activities in the manufacture of printed wiring assemblies (PWA's). Rework is defined as all actions taken to correct or improve the basic assembly process. These actions may include those of inspectors and solder touchup technicians who do not add value to the PWA, but whose actions are required in order to produce acceptable yields from the manufacturing process. Two alternative rework strategies for cont...

  19. Alternatives generation and analysis for the phase 1 high-level waste pretreatment process selection

    International Nuclear Information System (INIS)

    This report evaluates the effects of enhanced sludge washing and sludge washing without caustic leaching during the preparation of the Phase 1 high-level waste feeds. The pretreatment processing alternatives are evaluated against their ability to satisfy contractual, cost minimization, and other criteria. The information contained in this report is consistent with, and supplemental to, the Tank Waste Remediation System Operation and Utilization Plan (Kirkbride et al. 1997)

  20. Analysis of Alternative Institutional Arrangements for Reform of U.S. Air Traffic Control

    OpenAIRE

    Lewis, Ira

    2004-01-01

    A considerable amount of New Public Management-oriented research investigates alternative institutional arrangements for provision of services to the public. Some of this work argues in support of service delivery through an increase in outsourcing or by privatization of existing government functions. Air traffic control is provided to aircraft operators using airports and airspace all over the world. This article studies institutional arrangements of provision of air traffic c...

  1. Analysis of the relevance of crowdfunding as an alternative source of finance for social enterprises

    OpenAIRE

    Priede Bergamini, Tiziana; López-Cózar Navarro, Cristina; Hilliard, Ivan

    2015-01-01

    Social entrepreneurship is the creation of a business project based on the identification and resolution of a social or environmental issue. Although recent years have seen an increase in published articles addressing various aspects of social entrepreneurship, the number of works dealing specifically with funding is quite limited, and even more so in the case of those which focus on alternative financing options such as crowdfunding. Therefore, the main objective of this paper is to analyze ...

  2. Immobilized high-level waste interim storage alternatives generation and analysis and decision report

    Energy Technology Data Exchange (ETDEWEB)

    CALMUS, R.B.

    1999-05-18

    This report presents a study of alternative system architectures to provide onsite interim storage for the immobilized high-level waste produced by the Tank Waste Remediation System (TWRS) privatization vendor. It examines the contract and program changes that have occurred and evaluates their impacts on the baseline immobilized high-level waste (IHLW) interim storage strategy. In addition, this report documents the recommended initial interim storage architecture and implementation path forward.

  3. Genome-wide analysis of light-regulated alternative splicing mediated by photoreceptors in Physcomitrella patens

    OpenAIRE

    Wu, Hshin-Ping; Su, Yi-shin; Chen, Hsiu-Chen; Chen, Yu-Rong; Wu, Chia-Chen; Lin, Wen-Dar; Tu, Shih-Long

    2014-01-01

    Background Light is one of the most important factors regulating plant growth and development. Light-sensing photoreceptors tightly regulate gene expression to control photomorphogenic responses. Although many levels of gene expression are modulated by photoreceptors, regulation at the mRNA splicing step remains unclear. Results We performed high-throughput mRNA sequencing to analyze light-responsive changes in alternative splicing in the moss Physcomitrella patens, and found that a large num...

  4. Alternative security

    International Nuclear Information System (INIS)

    This book contains the following chapters: The Military and Alternative Security: New Missions for Stable Conventional Security; Technology and Alternative Security: A Cherished Myth Expires; Law and Alternative Security: Toward a Just World Peace; Politics and Alternative Security: Toward a More Democratic, Therefore More Peaceful, World; Economics and Alternative Security: Toward a Peacekeeping International Economy; Psychology and Alternative Security: Needs, Perceptions, and Misperceptions; Religion and Alternative Security: A Prophetic Vision; and Toward Post-Nuclear Global Security: An Overview

  5. Genome-wide analysis of alternative splicing of pre-mRNA under salt stress in Arabidopsis

    KAUST Repository

    Ding, Feng

    2014-06-04

    Background: Alternative splicing (AS) of precursor mRNA (pre-mRNA) is an important gene regulation process that potentially regulates many physiological processes in plants, including the response to abiotic stresses such as salt stress.Results: To analyze global changes in AS under salt stress, we obtained high-coverage (~200 times) RNA sequencing data from Arabidopsis thaliana seedlings that were treated with different concentrations of NaCl. We detected that ~49% of all intron-containing genes were alternatively spliced under salt stress, 10% of which experienced significant differential alternative splicing (DAS). Furthermore, AS increased significantly under salt stress compared with under unstressed conditions. We demonstrated that most DAS genes were not differentially regulated by salt stress, suggesting that AS may represent an independent layer of gene regulation in response to stress. Our analysis of functional categories suggested that DAS genes were associated with specific functional pathways, such as the pathways for the responses to stresses and RNA splicing. We revealed that serine/arginine-rich (SR) splicing factors were frequently and specifically regulated in AS under salt stresses, suggesting a complex loop in AS regulation for stress adaptation. We also showed that alternative splicing site selection (SS) occurred most frequently at 4 nucleotides upstream or downstream of the dominant sites and that exon skipping tended to link with alternative SS.Conclusions: Our study provided a comprehensive view of AS under salt stress and revealed novel insights into the potential roles of AS in plant response to salt stress. 2014 Ding et al.; licensee BioMed Central Ltd.

  6. Economic efficiency of alternative and conventional energy resources - a comparative analysis

    International Nuclear Information System (INIS)

    With more people in the world seeking improved living standard, businesses are using more and more energy to meet growing demand. Within a few years, easily accessible reserves of conventional energy will not be able to match this pace of growth. Consequences for nature, in terms of CO2 emission, depletion and degradation of natural resources are severe. From the standpoint of economic efficiency, many economies are in favor of conventional resources, but for a cleaner and safer world, alternative energy should make up a larger share of the energy mix

  7. Analysis of the Operating Modes of an Integrated Starter Alternator for Automotive Applications

    Directory of Open Access Journals (Sweden)

    HANGIU Radu-Petru

    2013-05-01

    Full Text Available Hybrid electric vehicles (HEVs are a goodcompromise between full electric vehicles andconventional combustion engine vehicles. A simplehybrid electric vehicle configuration can be obtainedby fitting a starter-alternator unit to an internalcombustion engine (ICE vehicle. In this wayconsiderable fuel savings and emission reductions canbe achieved, especially in urban driving, by employingstrategies such as start-stop, power boost orregenerative braking. This paper firstly presents therequirements and operating modes of a starteralternatorsystem followed by the presentation ofdynamic models for simulating the ICE crankingprocess and the generator operation of the system.

  8. Phylogenetic Analysis of Gene Structure and Alternative Splicing in α-Actinins

    OpenAIRE

    Lek, Monkol; MacArthur, Daniel G.; Yang, Nan; North, Kathryn N.

    2009-01-01

    The α-actinins are an important family of actin-binding proteins with the ability to cross-link actin filaments when in dimer form. Members of the α-actinin family share a domain topology composed of highly conserved actin-binding and EF-hand domains separated by a rod domain composed of spectrin-like repeats. Functional diversity within this family has arisen through exon duplication and the formation of alternate splice isoforms as well as gene duplications during the evolution of vertebrat...

  9. Loneliness and solitude in adolescence: A confirmatory factor analysis of alternative models

    DEFF Research Database (Denmark)

    Goossens, Luc; Lasgaard, Mathias; Luyckx, Koen;

    2009-01-01

    completed by a sample of mid-adolescents (N = 534) from Grades 10 through 12 (aged 15-18 years) in the Dutch-speaking part of Belgium. As expected, the four-factor solution provided a better fit to the data than did alternative models that comprised just a single factor, or two and three factors. Use of the...... Loneliness and Aloneness Scale for Children and Adolescents (LACA) is recommended, because the instrument measures all four aspects of the model. Implications for current theories on adolescent loneliness and associated phenomena, such as adolescents' attitude toward being on their own, are briefly discussed....

  10. Evaluation of alternative pollutant emission control strategies to urban water systems using substance flow analysis

    DEFF Research Database (Denmark)

    Lundy, L.; Revitt, D. M.; Eriksson, Eva;

    2011-01-01

    The EU Water Framework Directive (WFD) requires Member States to protect their inland (and coastal) surface and groundwater bodies. However, the way in which WFD requirements can be met, including the associated stringent environmental quality standards, is less clear. This paper presents selected...... emissions on a compartment-by-compartment basis indicates that the impact of a particular ECS is sensitive to both pollutant and city-specific characteristics. Whilst reductions in emissions to one compartment are typically associated with an increase in emissions to an alternative compartment, the final...

  11. Input-output analysis of alternative policies implemented on the energy activities: An application for Catalonia

    International Nuclear Information System (INIS)

    The aim of this paper is to analyze the economic impact of alternative policies implemented on the energy activities of the Catalan production system. Specifically, we analyze the effects of a tax on intermediate energy uses, a reduction in intermediate energy demand, and a tax on intermediate uses combined with a reduction in intermediate energy demand. The methodology involves two versions of the input-output price model: a competitive price formulation and a mark-up price formulation. The input-output price framework will make it possible to evaluate how the alternative measures modify production prices, consumption prices, private real income, and intermediate energy uses. The empirical application is for the Catalan economy and uses economic data for the year 2001. The combination of a tax on energy uses and an improvement in the energy efficiency of the production system is a measure that accomplishes both economic and environmental goals, since it has no effects on prices, it has a positive effect on private real income and, finally, energy consumption is considerably reduced. (author)

  12. Input-output analysis of alternative policies implemented on the energy activities: An application for Catalonia

    International Nuclear Information System (INIS)

    The aim of this paper is to analyze the economic impact of alternative policies implemented on the energy activities of the Catalan production system. Specifically, we analyze the effects of a tax on intermediate energy uses, a reduction in intermediate energy demand, and a tax on intermediate uses combined with a reduction in intermediate energy demand. The methodology involves two versions of the input-output price model: a competitive price formulation and a mark-up price formulation. The input-output price framework will make it possible to evaluate how the alternative measures modify production prices, consumption prices, private real income, and intermediate energy uses. The empirical application is for the Catalan economy and uses economic data for the year 2001. The combination of a tax on energy uses and an improvement in the energy efficiency of the production system is a measure that accomplishes both economic and environmental goals, since it has no effects on prices, it has a positive effect on private real income and, finally, energy consumption is considerably reduced

  13. Computational analysis of translational readthrough proteins in Drosophila and yeast reveals parallels to alternative splicing.

    Science.gov (United States)

    Pancsa, Rita; Macossay-Castillo, Mauricio; Kosol, Simone; Tompa, Peter

    2016-01-01

    In translational readthrough (TR) the ribosome continues extending the nascent protein beyond the first in-frame termination codon. Due to the lack of dedicated analyses of eukaryotic TR cases, the associated functional-evolutionary advantages are still unclear. Here, based on a variety of computational methods, we describe the structural and functional properties of previously proposed D. melanogaster and S. cerevisiae TR proteins and extensions. We found that in D. melanogaster TR affects long proteins in mainly regulatory roles. Their TR-extensions are structurally disordered and rich in binding motifs, which, together with their cell-type- and developmental stage-dependent inclusion, suggest that similarly to alternatively spliced exons they rewire cellular interaction networks in a temporally and spatially controlled manner. In contrast, yeast TR proteins are rather short and fulfil mainly housekeeping functions, like translation. Yeast extensions usually lack disorder and linear motifs, which precludes elucidating their functional relevance with sufficient confidence. Therefore we propose that by being much more restricted and by lacking clear functional hallmarks in yeast as opposed to fruit fly, TR shows remarkable parallels with alternative splicing. Additionally, the lack of conservation of TR extensions among orthologous TR proteins suggests that TR-mediated functions may be generally specific to lower taxonomic levels. PMID:27561673

  14. Analysis of words to development of augmentative and alternative communication boards for disabled student

    Directory of Open Access Journals (Sweden)

    Andréa Carla Paura

    2011-12-01

    Full Text Available Purpose: The aim of this study was to analyze the contribution of the words used in language assessment instruments and/or the vocabulary used in Brazil for the development of alternative communication boards. Methods: word lists from the selected assessment instruments were analyzed through a protocol designed for this purpose. The frequency of occurrence of each word was verified considering four word lists from the instruments and the frequency of occurrence of these words according to the classification proposed by Comunication Pictu Symbols system - PCS. Results: Results showed that the frequency words occurred only once was of 67.88% and the frequency of occurrence of concrete and abstract nouns in the instruments was 60.04%. The instrument that presented words with more than one occurrence was the Vocabulary Test-PPVT Peabody Picture. Conclusions: The use of tool that are already used and standardized may contribute to the process of evaluation, selection and deployment of augmentative and alternative communication resources for children and youth with disabilities.

  15. Protective Alternatives of SMR against Extreme Threat Scenario – A Preliminary Risk Analysis

    International Nuclear Information System (INIS)

    The article presents a preliminary risk analysis of the main features in NPP (Nuclear Power Plant) that includes SMR - Small and Modular Reactors, given an extreme threat scenario. A review of the structure and systems of the SMR is followed by systematic definitions and analysis of the threat scenario to which a preliminary risk analysis was carried out. The article outlines the basic events caused by the referred threat scenario, which had led to possible failure mechanisms according to FTA (Fault-Tree-Analysis),critical protective circuits, and todetecting critical topics for the protection and safety of the reactor

  16. Product liability and small wind energy conversion systems (SWECS): an analysis of selected issues and policy alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Noun, R.J.

    1979-12-01

    An overview is presented of the various legal issues regarding SWECS performance and safety, according to when such issues may arise during the SWECS manufacturing and marketing processes. Next, the most significant issues are translated into a series of questions, followed by a legal analysis that addresses these questions within the framework of the present product litigation system. The special problems presented to SWECS by judicial treatment of design defect cases and the relevance of industry standards in product cases are emphasized. Finally, a number of policy alternatives for DOE and others to consider are examined concerning their relative advantages and disadvantages in dealing with selected issues.

  17. Determining the Number of Principal Components to Retain via Parallel Analysis: Alternatives to Monte Carlo Analyses.

    Science.gov (United States)

    Lautenschlager, Gary J.

    The parallel analysis method for determining the number of components to retain in a principal components analysis has received a recent resurgence of support and interest. However, researchers and practitioners desiring to use this criterion have been hampered by the required Monte Carlo analyses needed to develop the criteria. Two recent…

  18. An empirical analysis on the adoption of alternative fuel vehicles: The case of natural gas vehicles

    International Nuclear Information System (INIS)

    The adoption of alternative fuel vehicles (AFVs) has been regarded as one of the most important strategies to address the issues of energy dependence, air quality, and, more recently, climate change. Despite decades of effort, we still face daunting challenges to promote wider acceptance of AFVs by the general public. More empirical analyses are needed to understand the technology adoption process associated with different market structures, the effectiveness of regulations and incentives, and the density of infrastructure adequate to reach sustainable commercial application. This paper compares the adoption of natural gas vehicles (NGVs) in eight countries: Argentina, Brazil, China, India, Italy, New Zealand, Pakistan, and the US. It examines the major policies aimed at promoting the use of NGVs, instruments for implementing those policies and targeting likely stakeholders, and a range of factors that influence the adoption of NGVs. The findings in this paper should be applicable to other AFVs

  19. 'Backscratching' alternative to PRSI pattern recognition. [position, rotation, and scale-independent image analysis

    Science.gov (United States)

    Monroe, Stanley E., Jr.; Juday, Richard D.

    1990-01-01

    The Backscratching optical correlation algorithm has been proposed for four degree of freedom tracking. In an alternating Cartesian and log-polar implementation, the tracked parameters are scale, rotation, and two-dimenisonal translation. The algorithm has a finite capture radius in the four-dimensional tracking space. The capture radius is dependent on the tracked object, the correlator architecture, and the method of filter computation. Some methods of extending the capture radius are discussed. One is a modification of matched filters, another is a careful consideration of log-polar transform center, and another is an operational method. Some simulations of the filter construction method, in which a larger capture radius is gained at the expense of precision in determining the four parameters are presented.

  20. Aptamer-Based Analysis: A Promising Alternative for Food Safety Control

    Directory of Open Access Journals (Sweden)

    Sonia Amaya-González

    2013-11-01

    Full Text Available Ensuring food safety is nowadays a top priority of authorities and professional players in the food supply chain. One of the key challenges to determine the safety of food and guarantee a high level of consumer protection is the availability of fast, sensitive and reliable analytical methods to identify specific hazards associated to food before they become a health problem. The limitations of existing methods have encouraged the development of new technologies, among them biosensors. Success in biosensor design depends largely on the development of novel receptors with enhanced affinity to the target, while being stable and economical. Aptamers fulfill these characteristics, and thus have surfaced as promising alternatives to natural receptors. This Review describes analytical strategies developed so far using aptamers for the control of pathogens, allergens, adulterants, toxins and other forbidden contaminants to ensure food safety. The main progresses to date are presented, highlighting potential prospects for the future.

  1. Efficiency and exhaust gas analysis of variable compression ratio spark ignition engine fuelled with alternative fuels

    Directory of Open Access Journals (Sweden)

    N. Seshaiah

    2010-09-01

    Full Text Available Considering energy crises and pollution problems today, investigations have been concentrated on decreasing fuel consumption by using alternative fuels and on lowering the concentration of toxic components in combustion products. In the present work, the variable compression ratio spark ignition engine designed to run on gasoline has been tested with pure gasoline, LPG (Isobutene, and gasoline blended with ethanol 10%, 15%, 25% and 35% by volume. Also, the gasoline mixed with kerosene at 15%, 25% and 35% by volume without any engine modifications has been tested and presented the result. Brake thermal and volumetric efficiency variation with brake load is compared and presented. CO and CO2 emissions have been also compared for all tested fuels.

  2. Measurement and analysis of fission rate in alternate depleted uranium/polyethylene shells

    International Nuclear Information System (INIS)

    In order to check the conceptual design of the subcritical blanket in fusion-fission hybrid reactor, an integral experiment was carried out in alternate depleted uranium/polyethylene shells with 14 MeV neutron using activation technique. The 238U (n, f) and 235U (n, f) reaction rates at 90° direction to the incident D beam were determined by measuring the 293.3 keV γ ray emitted from 143Ce which is generated by 238U (n, f) and 235U (n, f) reactions. The experiment was simulated using MCNP5 code with ENDF/B-Ⅵ library, and the calculated 238U (n. f) and 235U (n, f) reaction rates are generally 5% higher than experimental results. (authors)

  3. Economic analysis of alternate uses and design. Crosbyton Solar Power project

    Energy Technology Data Exchange (ETDEWEB)

    Jonish, J.E.; O' Hair, E.A.

    1986-09-01

    This portion of the Crosbyton Solar Power Project (CSPP) has four objectives: (1) to provide a brief overview for the design, components and estimated energy performance of the baseline 60/sup 0/ rim solar bowl technology or FMDF; (2) to explain the basis for the cost estimates of the baseline 60/sup 0/ bowl and the alternate shallow bowl design, and to examine potential sensitivities in cost due to economies of scale and learning curve effects; (3) to provide life cycle cost simulations using the baseline and shallow bowl design and costs and annual performance estimates under a standardized set of model assumptions; and (4) to suggest potential applications of the CSPP concept in repowering, chemicals, fuel alcohol or malt beverages and integrated agriculture.

  4. PlantAPA: A Portal for Visualization and Analysis of Alternative Polyadenylation in Plants

    Science.gov (United States)

    Wu, Xiaohui; Zhang, Yumin; Li, Qingshun Q.

    2016-01-01

    Alternative polyadenylation (APA) is an important layer of gene regulation that produces mRNAs that have different 3′ ends and/or encode diverse protein isoforms. Up to 70% of annotated genes in plants undergo APA. Increasing numbers of poly(A) sites collected in various plant species demand new methods and tools to access and mine these data. We have created an open-access web service called PlantAPA (http://bmi.xmu.edu.cn/plantapa) to visualize and analyze genome-wide poly(A) sites in plants. PlantAPA provides various interactive and dynamic graphics and seamlessly integrates a genome browser that can profile heterogeneous cleavage sites and quantify expression patterns of poly(A) sites across different conditions. Particularly, through PlantAPA, users can analyze poly(A) sites in extended 3′ UTR regions, intergenic regions, and ambiguous regions owing to alternative transcription or RNA processing. In addition, it also provides tools for analyzing poly(A) site selections, 3′ UTR lengthening or shortening, non-canonical APA site switching, and differential gene expression between conditions, making it more powerful for the study of APA-mediated gene expression regulation. More importantly, PlantAPA offers a bioinformatics pipeline that allows users to upload their own short reads or ESTs for poly(A) site extraction, enabling users to further explore poly(A) site selection using stored PlantAPA poly(A) sites together with their own poly(A) site datasets. To date, PlantAPA hosts the largest database of APA sites in plants, including Oryza sativa, Arabidopsis thaliana, Medicago truncatula, and Chlamydomonas reinhardtii. As a user-friendly web service, PlantAPA will be a valuable addition to the community of biologists studying APA mechanisms and gene expression regulation in plants. PMID:27446120

  5. STATISTICAL ANALYSIS ON THE PERFORMANCE OF ENGINE WITH JATROPHA OIL AS AN ALTERNATE FUEL

    Directory of Open Access Journals (Sweden)

    V.R. Sivakumar,

    2010-12-01

    Full Text Available The rapid depletion in world petroleum reserves and uncertainty in petroleum supply due to political and economical reasons, as well as, the sharp escalation in petroleum prices, have stimulated the search for alternatives to petroleum based fuels specifically diesel and gasoline. Moreover, bulks of petroleum fuels are being consumed by agriculture and transport sector for which diesel engine happens to be the prime mover. Vegetable oils - due to their properties being close to diesel fuel may he a promising alternative for its use in diesel engine, But, their high viscosity prevents them from using it directly in an engine. Present investigation focuses on the use of Jatropha curcas seed based oil as fuel in diesel engine by blending it with diesel for dilution of viscosity and preheating it for reduction of viscosity. Performance tests were conducted on a single cylinder diesel engine and 'important characteristics of the engine such as Brake Thermal Efficiency (BTE and Specific fuel consumption (SFC have been evaluated. In this study, the statistical experimental method of four-factors, five-level factorial central composite rotatable design has been used to develop mathematical models to correlate fuel parameters with specific fuel consumption and Brake Thermal Efficiency of an engine. Direct and interaction effects of fuel parameters on engine performance were analyzed andpresented in the graphical form. Further, these mathematical models help to optimize the engine performance. From the test results it has been established that 20% of jatropha oil blend with preheating to a maximum temperature of 47 0C can be a better substitute for diesel without any engine modification.

  6. Project Alternative Systems Study - PASS. Analysis of performance and long-term safety of repository concepts

    International Nuclear Information System (INIS)

    This study is part of the Project on Alternative Systems Study, PASS, with the overall aim to perform a technical/economical ranking of alternative repository concepts and canisters for the final storage of spent nuclear fuel. The comparison should in the first stage separately assess technology in construction and operation, long-term performance and safety, and costs. Three of the repository concepts are assumed to be located at a depth of approximately 500 m in the host rock, KBS-3, Very Long Holes (VLH) and Medium Long Holes (MLH). In the KBS-3 concept the canisters are deposited in vertical deposition holes in a system of parallel storage tunnels. In the VLH concept larger canisters are deposited in long horizontal tunnels. The MLH concept, is an evolution of the two other concepts, with KBS-3 type canisters deposited in horizontal tunnels. Smaller canisters are to be deposited in deep bore holes at a depth between 2000 to 4000 m in the Very Deep Holes (VDH) concept. In all concepts the canisters will be surrounded by a bentonite buffer. The aim of the present study is to analyze and compare the performance and long-term safety of the repository concepts. Only a qualitative comparison of the concepts is made as no calculations of radionuclide releases or dose to man have been performed. The ranking of the repository concepts was carried out by comparing the VDH, VLH and MLH concept with the KBS-3 concept. The performance and long-term safety of the repositories located at 500 m level will be based on a multiple barrier system and the predictions for the concepts will involve similar uncertainties. (54 refs.)

  7. Analysis of removal alternatives for the Heavy Water Components Test Reactor at the Savannah River Site. Revision 1

    International Nuclear Information System (INIS)

    This engineering study evaluates different alternatives for decontamination and decommissioning of the Heavy Water Components Test Reactor (HWCTR). Cooled and moderated with pressurized heavy water, this uranium-fueled nuclear reactor was designed to test fuel assemblies for heavy water power reactors. It was operated for this purpose from march of 1962 until December of 1964. Four alternatives studied in detail include: (1) dismantlement, in which all radioactive and hazardous contaminants would be removed, the containment dome dismantled and the property restored to a condition similar to its original preconstruction state; (2) partial dismantlement and interim safe storage, where radioactive equipment except for the reactor vessel and steam generators would be removed, along with hazardous materials, and the building sealed with remote monitoring equipment in place to permit limited inspections at five-year intervals; (3) conversion for beneficial reuse, in which most radioactive equipment and hazardous materials would be removed and the containment building converted to another use such as a storage facility for radioactive materials, and (4) entombment, which involves removing hazardous materials, filling the below-ground structure with concrete, removing the containment dome and pouring a concrete cap on the tomb. Also considered was safe storage, but this approach, which has, in effect, been followed for the past 30 years, did not warrant detailed evaluation. The four other alternatives were evaluate, taking into account factors such as potential effects on the environment, risks, effectiveness, ease of implementation and cost. The preferred alternative was determined to be dismantlement. This approach is recommended because it ranks highest in the comparative analysis, would serve as the best prototype for the site reactor decommissioning program and would be most compatible with site property reuse plans for the future

  8. Analysis of removal alternatives for the Heavy Water Components Test Reactor at the Savannah River Site. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Owen, M.B.

    1997-04-01

    This engineering study evaluates different alternatives for decontamination and decommissioning of the Heavy Water Components Test Reactor (HWCTR). Cooled and moderated with pressurized heavy water, this uranium-fueled nuclear reactor was designed to test fuel assemblies for heavy water power reactors. It was operated for this purpose from march of 1962 until December of 1964. Four alternatives studied in detail include: (1) dismantlement, in which all radioactive and hazardous contaminants would be removed, the containment dome dismantled and the property restored to a condition similar to its original preconstruction state; (2) partial dismantlement and interim safe storage, where radioactive equipment except for the reactor vessel and steam generators would be removed, along with hazardous materials, and the building sealed with remote monitoring equipment in place to permit limited inspections at five-year intervals; (3) conversion for beneficial reuse, in which most radioactive equipment and hazardous materials would be removed and the containment building converted to another use such as a storage facility for radioactive materials, and (4) entombment, which involves removing hazardous materials, filling the below-ground structure with concrete, removing the containment dome and pouring a concrete cap on the tomb. Also considered was safe storage, but this approach, which has, in effect, been followed for the past 30 years, did not warrant detailed evaluation. The four other alternatives were evaluate, taking into account factors such as potential effects on the environment, risks, effectiveness, ease of implementation and cost. The preferred alternative was determined to be dismantlement. This approach is recommended because it ranks highest in the comparative analysis, would serve as the best prototype for the site reactor decommissioning program and would be most compatible with site property reuse plans for the future.

  9. Analysis of long-term impacts of TRU waste remaining at generator/storage sites for No Action Alternative 2

    International Nuclear Information System (INIS)

    This report is a supplement to the Waste Isolation Pilot Plant Disposal-Phase Final Supplemental Environmental Impact Statement (SEIS-II). Described herein are the underlying information, data, and assumptions used to estimate the long-term human-health impacts from exposure to radionuclides and hazardous chemicals in transuranic (TRU) waste remaining at major generator/storage sites after loss of institutional control under No Action Alternative 2. Under No Action Alternative 2, TRU wastes would not be emplaced at the Waste Isolation Pilot Plant (WIPP) but would remain at generator/storage sites in surface or near-surface storage. Waste generated at smaller sites would be consolidated at the major generator/storage sites. Current TRU waste management practices would continue, but newly generated waste would be treated to meet the WIPP waste acceptance criteria. For this alternative, institutional control was assumed to be lost 100 years after the end of the waste generation period, with exposure to radionuclides and hazardous chemicals in the TRU waste possible from direct intrusion and release to the surrounding environment. The potential human-health impacts from exposure to radionuclides and hazardous chemicals in TRU waste were analyzed for two different types of scenarios. Both analyses estimated site-specific, human-health impacts at seven major generator/storage sites: the Hanford Site (Hanford), Idaho National Engineering and Environmental Laboratory (INEEL), Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Oak Ridge National Laboratory (ORNL), Rocky Flats Environmental Technology Site (RFETS), and Savannah River Site (SRS). The analysis focused on these seven sites because 99 % of the estimated TRU waste volume and inventory would remain there under the assumptions of No Action Alternative 2

  10. An alternative method for the analysis of neuron passive electrical data which uses integrals of voltage transients.

    Science.gov (United States)

    Engelhardt, J K; Morales, F R; Chase, M H

    1998-06-01

    The traditional method for analyzing passive electrical data from neurons when specific morphological data are unavailable consists of decomposing the voltage response of the cell into a series of exponential functions (the peeling method) and substituting the time constants of these exponential functions into equations derived from cable theory (Rall W, Core conductor theory and cable properties of neurons. In: Handbook of Physiology. The Nervous System. Cellular Biology of Neurons. Bethesda, MD. Am Physiol Soc. Section 1, Part 1, 1977;1(3):39-97). In the present report, an alternative method is examined for analyzing these kinds of data, the integrals of transients method (Eisenberg RS, Mathias RT. Structural analysis of electrical properties of cells and tissues. CRC Critical Reviews in Bioengineering 1980;4:203-232). The integrals required are easily obtained from input resistance data and any theoretical model that is appropriate for the neurons under study can be used, provided that the impedance function can be determined. In order to demonstrate this alternative method, a simple 3-compartment model with both dendritic taper and somatic shunt is used to model data obtained from fast-type alpha-motoneurons in the spinal cord of the cat. These results are compared with results obtained using the traditional peeling method. This comparison indicates that passive electrical data from fast-type motoneurons are best analyzed using a theoretical model that includes both dendritic taper and somatic shunt. Furthermore, our results show that the integrals of transients method can facilitate this analysis. PMID:9696318

  11. Analysis of the use of biomass as an energy alternative for the Portuguese textile dyeing industry

    International Nuclear Information System (INIS)

    The energy efficiency and the development of environmentally correct policies are current topics, especially when applied to the industrial sector with the objective of increasing the competitiveness of the enterprises. Portuguese textile dyeing sector, being a major consumer sector of primary energy, needs to adopt measures to improve its competitiveness. Biomass appears to be a viable and preferred alternative energy source for the sector, while simultaneously develops an entire forest industry devoted to the supply of forest solid fuels. This work carries out a comprehensive PEST (political, economic, social and technological) analysis, which analyses Political, Economic, Social and Technological aspects of the replacement of the fossil fuels traditionally used in this sector by biomass, providing a framework of environmental factors that influence the strategic management of the companies. The main advantages are the reduction of external dependence on imported fuel due to the use of an endogenous renewable resource, the creation and preservation of jobs, the increased competitiveness of the sector by reducing energy costs, the use of national technology and the reduction of greenhouse gases emissions. - Highlights: • The Portuguese textile dyeing sector, being a major consumer sector of primary energy, is addressed. • Biomass is a viable and preferred alternative energy source for the sector. • A PEST (political, economic, social and technological) analysis is carried out. • The implications of the replacement of fossil fuels with biomass are studied

  12. Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA

    International Nuclear Information System (INIS)

    Poly(A)+ RNA, isolated from a single 7-mo fetal human aorta, was used to synthesize cDNA by the RNase H method, and the cDNA was inserted into λgt10. Recombinant phage containing elastin sequences were identified by hybridization with cloned, exon-containing fragments of the human elastin gene. Three clones containing inserts of 3.3, 2.7, and 2.3 kilobases were selected for further analysis. Three overlapping clones containing 17.8 kilobases of the human elastin gene were also isolated from genomic libraries. Complete sequence analysis of the six clones demonstrated that: (i) the cDNA encompassed the entire translated portion of the mRNA encoding 786 amino acids, including several unusual hydrophilic amino acid sequences not previously identified in porcine tropoelastin, (ii) exons encoding either hydrophobic or crosslinking domains in the protein alternated in the gene, and (iii) a great abundance of Alu repetitive sequences occurred throughout the introns. The data also indicated substantial alternative splicing of the mRNA. These results suggest the potential for significant variation in the precise molecular structure of the elastic fiber in the human population

  13. Scaling analysis of heart beat fluctuations data and its relationship with cyclic alternating pattern data during sleep

    Science.gov (United States)

    de León-Lomelí, R.; Murguía, J. S.; Chouvarda, I.; Méndez, M. O.; González-Galván, E.; Alba, A.

    2016-01-01

    During sleep there exists a nonlinear dynamic phenomenon, which is called cyclic alternating pattern. This phenomenon is generated in the brain and is composed of a series of events of short duration known as A-phases. It has been shown that A-phases can be found in other physiological systems such as the cardiovascular. However, there is no evidence that shows the temporal influence of the A-phases with the cardiovascular system. For this purpose, we consider the scaling method known as detrended fluctuation analysis (DFA). The analysis was carried out in well sleepers and insomnia people, and the numerical results show an increment in the scaling parameter for the insomnia subjects compared with the normal ones. In addition, the results of the heart dynamics suggests a persistent behavior toward the 1/f-noise.

  14. Electric Demand Analysis of the Tunisian Network: Trends and Short Term Photovoltaic Implementation with Alternatives Prospects and Technologies

    Directory of Open Access Journals (Sweden)

    J. Bouattour

    2014-08-01

    Full Text Available The main objective of this study is to analyze the system of electric demand in Tunisia and to propose immediate alternative solution of photovoltaic implementation that can be suitable based on available natural solar energy resources in the country to respond to the short Forecast peak demand growth and energy consumptions taking into account financial strain. On the first step, analysis of the situation based on the recent historical data is proposed. In a second step, a solution is considered, based on photovoltaic implementation and using the results of historical data analysis. The resulting benefits are highlighted: financial, technical, environmental and social. Future studies may be made to use a mix of technology and policy as well: among it combining photovoltaic and battery storage, in parallel with energy efficiency programs.

  15. Hemp Thermal Insulation Concrete with Alternative Binders, Analysis of their Thermal and Mechanical Properties

    Science.gov (United States)

    Sinka, M.; Sahmenko, G.; Korjakins, A.; Radina, L.; Bajare, D.

    2015-11-01

    One of the main challenges that construction industry faces today is how to address the demands for more sustainable, environmentally friendly and carbon neutral construction materials and building upkeep processes. One of the answers to these demands is lime-hemp concrete (LHC) building materials - carbon negative materials that have sufficient thermal insulation capabilities to be used as thermal insulation materials for new as well as for existing buildings. But one problem needs to be overcome before these materials can be used on a large scale - current manufacturing technology allows these materials to be used only as self-bearing thermal insulation material with large labour intensity in the manufacturing process. In order to lower the labour intensity and allow the material to be used in wider applications, a LHC block and board production is necessary, which in turn calls for the binders different from the classically used ones, as they show insufficient mechanical strength for this new use. The particular study focuses on alternative binders produced using gypsum-cement compositions ensuring they are usable in outdoor applications together with hemp shives. Physical, mechanical, thermal and water absorption properties of hemp concrete with various binders are addressed in the current study.

  16. Global analysis of Salmonella alternative sigma factor E on protein translation

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jie; Nakayasu, Ernesto S.; Overall, Christopher C.; Johnson, Rudd; Kidwai, Afshan S.; McDermott, Jason E.; Ansong, Charles; Heffron, Fred; Cambronne, Eric; Adkins, Joshua N.

    2015-04-03

    The alternative sigma factor E (σE) is critical for response to extracytoplasmic stress in Salmonella. Extensive studies have been conducted on σE-regulated gene expression, particularly at the transcriptional level. Increasing evidence suggests however that σE may indirectly participate in post-transcriptional regulation. In this study, we conducted sample-matched global proteomic and transcriptomic analyses to determine the level of regulation mediated by σE in Salmonella. Samples were analyzed from wild type and isogenic rpoE mutant Salmonella cultivated in three different conditions; nutrient-rich and conditions that mimic early and late intracellular infection. We found that 30% of the observed proteome was regulated by σE combining all three conditions. In different growth conditions, σE affected the expression of a broad spectrum of Salmonella proteins required for miscellaneous functions. Those involved in transport and binding, protein synthesis, and stress response were particularly highlighted. By comparing transcriptomic and proteomic data, we identified genes post-transcriptionally regulated by σE and found that post-transcriptional regulation was responsible for a majority of changes observed in the σE-regulated proteome. Further, comparison of transcriptomic and proteomic data from hfq mutant of Salmonella demonstrated that σE–mediated post-transcriptional regulation was partially dependent on the RNA-binding protein Hfq.

  17. Comparative cost analysis -- computed tomography vs. alternative diagnostic procedures, 1977-1980

    International Nuclear Information System (INIS)

    In comparing the total national cost of utilizing computed tomography (CT) for medically indicated diagnoses with that of conventional x-ray, ultrasonography, nuclear medicine, and exploratory surgery, this investigation concludes that there was little, if any, added net cost from CT use in 1977 or will there be in 1980. Computed tomography, generally recognized as a reliable and useful diagnostic modality, has the potential to reduce net costs provided that an optimal number of units can be made available to physicians and patients to achieve projected reductions in alternative procedures. This study examines the actual cost impact of CT on both cranial and body diagnostic procedures. For abdominal and mediastinal disorders, CT scanning is just beginning to emerge as a diagnostic modality. As such, clinical experience is somewhat limited and the authors assume that no significant reduction in conventional procedures took place in 1977. It is estimated that the approximately 375,000 CT body procedures performed in 1977 represent only a 5 percent cost increase over use of other diagnostic modalities. It is projected that 2,400,000 CT body procedures will be performed in 1980 and, depending on assumptions used, total body diagnostic costs will increase only slightly or be reduced. Thirty-one tables appear throughout the text presenting cost data broken down by types of diagnostic procedures used and projections by years. Appendixes present technical cost components for diagnostic procedures, the comparative efficacy of CT as revealed in abstracts of published literature, selected medical diagnoses, and references

  18. Economical analysis of an alternative strategy for CO2 mitigation based on nuclear power

    International Nuclear Information System (INIS)

    Many countries are pursuing greenhouse gas (GHG) mitigation policies resulting in the increase of use of renewable sources in the electricity sector to mitigate CO2 emissions. Nuclear energy is a non-emitting CO2 source that could be used as part of that policy. However, its main drawback is the high investment required for its deployment. On the other hand, wind power is the clean source preferred option to mitigate CO2 emissions. However, due to its intermittence backup power is needed, in most of the cases it must be provided with combined cycle thermal plants using natural gas. This study performs an economical comparison of a hypothetical implementation of a nuclear strategy to meet the same CO2 emissions reduction goal that has been obtained by the actual Spaniard strategy (2005–2010) based on wind power. The investment required in both strategies is assessed under different investment scenarios and electricity production conditions for nuclear power. Also, the cost of electricity generation is compared for both strategies. - Highlights: ► Wind power electricity cost including its backup in Spain is assessed. ► Nuclear power is proposed as an alternative to produce the same CO2 reduction. ► Nuclear power requires less installed capacity deployment. ► Investment to produce the same CO2 reduction is smaller using nuclear power. ► Electricity generating cost is less expensive using the nuclear option

  19. Economic Analysis of Alternative Strategies for Detection of ALK Rearrangements in Non Small Cell Lung Cancer.

    Science.gov (United States)

    Doshi, Shivang; Ray, David; Stein, Karen; Zhang, Jie; Koduru, Prasad; Fogt, Franz; Wellman, Axel; Wat, Ricky; Mathews, Charles

    2016-01-01

    Identification of alterations in ALK gene and development of ALK-directed therapies have increased the need for accurate and efficient detection methodologies. To date, research has focused on the concordance between the two most commonly used technologies, fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC). However, inter-test concordance reflects only one, albeit important, aspect of the diagnostic process; laboratories, hospitals, and payors must understand the cost and workflow of ALK rearrangement detection strategies. Through literature review combined with interviews of pathologists and laboratory directors in the U.S. and Europe, a cost-impact model was developed that compared four alternative testing strategies-IHC only, FISH only, IHC pre-screen followed by FISH confirmation, and parallel testing by both IHC and FISH. Interviews were focused on costs of reagents, consumables, equipment, and personnel. The resulting model showed that testing by IHC alone cost less ($90.07 in the U.S., $68.69 in Europe) than either independent or parallel testing by both FISH and IHC ($441.85 in the U.S. and $279.46 in Europe). The strategies differed in cost of execution, turnaround time, reimbursement, and number of positive results detected, suggesting that laboratories must weigh the costs and the clinical benefit of available ALK testing strategies. PMID:26838801

  20. Economic Analysis of Alternative Strategies for Detection of ALK Rearrangements in Non Small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Shivang Doshi

    2016-01-01

    Full Text Available Identification of alterations in ALK gene and development of ALK-directed therapies have increased the need for accurate and efficient detection methodologies. To date, research has focused on the concordance between the two most commonly used technologies, fluorescent in situ hybridization (FISH and immunohistochemistry (IHC. However, inter-test concordance reflects only one, albeit important, aspect of the diagnostic process; laboratories, hospitals, and payors must understand the cost and workflow of ALK rearrangement detection strategies. Through literature review combined with interviews of pathologists and laboratory directors in the U.S. and Europe, a cost-impact model was developed that compared four alternative testing strategies—IHC only, FISH only, IHC pre-screen followed by FISH confirmation, and parallel testing by both IHC and FISH. Interviews were focused on costs of reagents, consumables, equipment, and personnel. The resulting model showed that testing by IHC alone cost less ($90.07 in the U.S., $68.69 in Europe than either independent or parallel testing by both FISH and IHC ($441.85 in the U.S. and $279.46 in Europe. The strategies differed in cost of execution, turnaround time, reimbursement, and number of positive results detected, suggesting that laboratories must weigh the costs and the clinical benefit of available ALK testing strategies.

  1. A COMPARATIVE ANALYSIS BETWEEN UNIT-LINKED LIFE INSURANCE AND OTHER ALTERNATIVE INVESTMENTS

    Directory of Open Access Journals (Sweden)

    CRISTINA CIUMAS

    2015-07-01

    Full Text Available The unit-linked life insurance has two important components: protection and investment. The protection component refers to the insured sum in case of the occurrence of insured risks and the investment component refers to the policyholder’s account that represents the present value of the units from the chosen investment funds.These financial products invest most of the premium paid by the insured person in the funds managed by the insurance company or an external administrator and the lower part of the premium is intended to cover the insured risk (death, disability, etc. An important component of the activity carried out by the insurance companies is the investment of the premiums paid by policyholders in various types of assets, in order to obtain higher yields than those guaranteed by the insurance contracts, while providing the necessary liquidity for the payment of insurance claims in case of occurrence of the assumed risks. This research contributes to the existing literature regarding the study of investment alternatives, with an exclusive focus on the investment in unit-linked life insurance. A special place in this study is the presentation of investments in unit-linked insurance versus other types of financial investments: deposits, treasury bills, shares (BET, currency (EURO and gold.

  2. In vitro determination of the indigestible fraction in foods: an alternative to dietary fiber analysis.

    Science.gov (United States)

    Saura-Calixto, F; García-Alonso, A; Goñi, I; Bravo, L

    2000-08-01

    Dietary fiber (DF) intakes in Western countries only accounts for about one-third of the substrates required for colonic bacterial cell turnover. There is a general trend among nutritionists to extend the DF concept to include all food constituents reaching the colon. In this line, a method to quantify the major nondigestible components in plant foods, namely, the indigestible fraction (IF), is presented. Analytical conditions for IF determination are close to physiological. Samples, analyzed as eaten, were successively incubated with pepsin and alpha-amylase; after centrifugation and dialysis, insoluble and soluble IFs were obtained. IF values include DF, resistant starch, resistant protein, and other associated compounds. IF contents determined in common foods (cereals, legumes, vegetables, and fruits) were higher than DF contents. Calculated IF intakes were close to the estimated amount of substrates reaching the colon. IF data could be more useful than DF data from a nutritional point of view; therefore, IF is proposed as an alternative to DF for food labeling and food composition tables. PMID:10956113

  3. Alternative method of highway traffic safety analysis for developing countries using delphi technique and Bayesian network.

    Science.gov (United States)

    Mbakwe, Anthony C; Saka, Anthony A; Choi, Keechoo; Lee, Young-Jae

    2016-08-01

    Highway traffic accidents all over the world result in more than 1.3 million fatalities annually. An alarming number of these fatalities occurs in developing countries. There are many risk factors that are associated with frequent accidents, heavy loss of lives, and property damage in developing countries. Unfortunately, poor record keeping practices are very difficult obstacle to overcome in striving to obtain a near accurate casualty and safety data. In light of the fact that there are numerous accident causes, any attempts to curb the escalating death and injury rates in developing countries must include the identification of the primary accident causes. This paper, therefore, seeks to show that the Delphi Technique is a suitable alternative method that can be exploited in generating highway traffic accident data through which the major accident causes can be identified. In order to authenticate the technique used, Korea, a country that underwent similar problems when it was in its early stages of development in addition to the availability of excellent highway safety records in its database, is chosen and utilized for this purpose. Validation of the methodology confirms the technique is suitable for application in developing countries. Furthermore, the Delphi Technique, in combination with the Bayesian Network Model, is utilized in modeling highway traffic accidents and forecasting accident rates in the countries of research. PMID:27183516

  4. An analysis of radiation effects on electronics and soi-mos devices as an alternative

    International Nuclear Information System (INIS)

    The effects of radiation on semiconductors and electronic components are analyzed. The performance of such circuitry depends upon the reliability of electronic devices where electronic components will be unavoidably exposed to radiation. This exposure can be detrimental or even fatal to the expected function of the devices. Single event effects (SEE), in particular, which lead to sudden device or system failure and total dose effects can reduce the lifetime of electronic devices in such systems are discussed. Silicon-on-insulator (SOI) technology is introduced as an alternative for radiation-hardened devices. I-V Characteristics Curves for SOI-MOS devices subjected to a different total radiation doses are illustrated. In addition, properties of some semiconductor materials such as diamond, diamond-like carbon films, SiC, GaP, and AlGaN/GaN are compared with those of SOI devices. The recognition of the potential usefulness of SOI-MOS semiconductor materials for harsh environments is discussed. A summary of radiation effects, impacts and mitigation techniques is also presented. (authors)

  5. Analysis of Burnup and Economic Potential of Alternative Fuel Materials in Thermal Reactors

    International Nuclear Information System (INIS)

    A strategy is proposed for the assessment of nuclear fuel material economic potential use in future light water reactors (LWRs). In this methodology, both the required enrichment and the fuel performance limits are considered. In order to select the best fuel candidate, the optimal burnup that produces the lowest annual fuel cost within the burnup potential for a given fuel material and smear density ratio is determined.Several nuclear materials are presented as examples of the application of the methodology proposed in this paper. The alternative fuels considered include uranium dioxide (UO2), uranium carbide (UC), uranium nitride (UN), metallic uranium (U-Zr alloy), combined thorium and uranium oxides (ThO2/UO2), and combined thorium and uranium metals (U/Th). For these examples, a typical LWR lattice geometry in a zirconium-based cladding was assumed. The uncertainties in the results presented are large due to the scarcity of experimental data regarding the behavior of the considered materials at high burnups. Also, chemical compatibility issues are to be considered separately.The same methodology can be applied in the future to evaluate the economic potential of other nuclear fuel materials including different cladding designs, dispersions of ceramics into ceramics, dispersions of ceramics into metals, and also for geometries other than the traditional circular fuel pin

  6. Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis

    Directory of Open Access Journals (Sweden)

    Laurila Kirsti

    2011-10-01

    Full Text Available Abstract Background Approximately half of all human genes use alternative transcription start sites (TSSs to control mRNA levels and broaden the transcriptional output in healthy tissues. Aberrant expression patterns promoting carcinogenesis, however, may arise from alternative promoter usage. Results By profiling 108 colorectal samples using exon arrays, we identified nine genes (TCF12, OSBPL1A, TRAK1, ANK3, CHEK1, UGP2, LMO7, ACSL5, and SCIN showing tumor-specific alternative TSS usage in both adenoma and cancer samples relative to normal mucosa. Analysis of independent exon array data sets corroborated these findings. Additionally, we confirmed the observed patterns for selected mRNAs using quantitative real-time reverse-transcription PCR. Interestingly, for some of the genes, the tumor-specific TSS usage was not restricted to colorectal cancer. A comprehensive survey of the nine genes in lung, bladder, liver, prostate, gastric, and brain cancer revealed significantly altered mRNA isoform ratios for CHEK1, OSBPL1A, and TCF12 in a subset of these cancer types. To identify the mechanism responsible for the shift in alternative TSS usage, we antagonized the Wnt-signaling pathway in DLD1 and Ls174T colorectal cancer cell lines, which remarkably led to a shift in the preferred TSS for both OSBPL1A and TRAK1. This indicated a regulatory role of the Wnt pathway in selecting TSS, possibly also involving TP53 and SOX9, as their transcription binding sites were enriched in the promoters of the tumor preferred isoforms together with their mRNA levels being increased in tumor samples. Finally, to evaluate the prognostic impact of the altered TSS usage, immunohistochemistry was used to show deregulation of the total protein levels of both TCF12 and OSBPL1A, corresponding to the mRNA levels observed. Furthermore, the level of nuclear TCF12 had a significant correlation to progression free survival in a cohort of 248 stage II colorectal cancer samples

  7. Warranty cost analysis using alternating quasi-renewal processes with a warranty option

    Science.gov (United States)

    Yedida, Sarada; Unnissa Munavar, Mubashir; Ranjani, R.

    2012-03-01

    This article analyses a repairable deteriorating system with quasi-renewal operating and repair times during warranty. To establish the importance of non-negligible repair times modelled with quasi-renewal processes in warranty cost analysis, a fixed warranty model is developed and the results are compared with an existing model using expected warranty cost. Sensitivity analysis and graphical illustrations are provided to highlight the effect of various cost parameters on the expected warranty cost by means of three different distributions. In order to examine the cost implications to the customer and manufacturer, an extended warranty model in which a manufacturer offers a warranty option to the customer with two different policies, has been proposed. Based on the long-run average cost per unit time, profit analysis has been carried out for the manufacturer as it is an essential aspect of warranty management. This article emphasises the incorporation of non-negligible 'improved' repair times during warranty.

  8. Cluster analysis in kinetic modelling of the brain: A noninvasive alternative to arterial sampling

    DEFF Research Database (Denmark)

    Liptrot, Matthew George; Adams, K.H.; Martiny, L.;

    2004-01-01

    extracted from the PET data set. Hierarchical K-means cluster analysis was performed on the PET time series to extract a cerebral vasculature ROI. The number of clusters was varied from K = 1 to 10 for the second of the two-stage method. Determination of the correct number of clusters was performed by the...... blood sampling, the Simplified Reference Tissue Model (SRTM) and Logan analysis with cerebellar TAC as an input. There was a good agreement (P < 0.05) between the values of Distribution Volume (DV) obtained from the K-means-clustered input function and those from the arterial blood samples. This work...

  9. ALTERNATIVE METHODS TO MULTIPLE CORRESPONDENCE ANALYSIS IN RECONSTRUCTING THE RELEVANT INFORMATION IN A BURT'S TABLE

    Directory of Open Access Journals (Sweden)

    Sergio Camiz

    2016-04-01

    Full Text Available ABSTRACT In this work, the reconstruction of the Burt's table, Greenacre (1988's Joint Correspondence Analysis (JCA, and Gower & Hand (1996's Extended Matching Coefficient (EMC are compared to Multiple Correspondence Analysis (MCA in order to check the quality of the methods. In particular, for the whole table, the ability is considered separately the diagonal, and the off-diagonal tables, that is the ability to describe either each character's distribution or the interaction between pairs of characters, or both. The theoretical aspects are discussed first, and finally the results obtained in an application are shown and discussed.

  10. NIRS as an alternative to conventional soil analysis for Greenland soils (focus on SOC)

    DEFF Research Database (Denmark)

    Knadel, Maria; Ogric, Mateja; Adhikari, Kabindra;

    Soil organic carbon (SOC) is an important soil property. It is the main constituents of soil organic matter and a good indicator of soil quality. The estimation and mapping of SOC content could be used to select potential agricultural areas in the Arctic areas. However, conventional analysis of SOC...

  11. Error Ratio Analysis: Alternate Mathematics Assessment for General and Special Educators.

    Science.gov (United States)

    Miller, James H.; Carr, Sonya C.

    1997-01-01

    Eighty-seven elementary students in grades four, five, and six, were administered a 30-item multiplication instrument to assess performance in computation across grade levels. An interpretation of student performance using error ratio analysis is provided and the use of this method with groups of students for instructional decision making is…

  12. A Suggested Approach for a Cost Analysis of Alternative IMS Configurations.

    Science.gov (United States)

    Besel, Ronald

    An approach to a cost analysis of pilot, prototype, model and operational versions of the Southwest Regional Laboratory's (SWRL) Instructional Management System (IMS) is described. Five classes of systems (conceptual, pilot, prototype, model and operational) are defined, and a system development process relating classes of systems in presented.…

  13. Development of systems of analysis in industrial processes with XRF. A technology transfer alternative

    International Nuclear Information System (INIS)

    The FRX Laboratory's experience in developing a unit of analysis by excitation with a radioisotope source is described, with a discussion of its advantages, limitations, types of existing units in the market, use, values and state-of-the-art. The evolution of mining and metallurgical processes has led to the development of new technologies that provide quick and precise control of control and analysis operations, avoiding loss of raw material, chemical reagents, waste of materials and time, to obtain a better quality and purer product. The system developed by the FRX Laboratory is relatively low cost compared to other equipment that is available in the market, and it focuses on single element analysis in hydrometallurgical processes. This system uses a NaI (T1) detector with a beryllium window, related electronics, monitor and printer, which controls the operation automatically using an adequate program for taking samples, measuring, analysis, printing results, changing samples, etc. The sampling is continuous, so it does not have to be taken or prepared chemically. This system can extrapolate to other more complex ones, using new kinds of detectors with higher resolution, more modern electronics, and new multichannel cards. The development of this kind of equipment in Chile means that dependence on foreign technology can be avoided by replacing expensive imported equipment, creating our own technology and transferring it to the domestic market, and even generating income by exporting these units and opening new development prospects (au)

  14. Data-driven urban drainage analysis: An alternative to hydrodynamic models?

    NARCIS (Netherlands)

    ten Veldhuis, J.A.E.; Tait, S.J.

    2011-01-01

    In the past, there has been an emphasis on the use of hydrodynamic models as a tool for urban drainage analysis. Limited availability of monitoring data and the perceived more limited resource requirements of models led to a preference for this approach. The last decade has seen a gradual developmen

  15. Complementary and alternative medicine use among older Australian women - a qualitative analysis

    Directory of Open Access Journals (Sweden)

    McLaughlin Deirdre

    2012-04-01

    Full Text Available Abstract Background The use of complementary and alternative medicines (CAM among older adults is an emerging health issue, however little is known about older people's experiences of using CAM and the cultural, geographical and other determinants of CAM use in this population. This study used qualitative methods to explore older women's views of CAM and reasons for their use of CAM. Participants for the project were drawn from the Australian Longitudinal Study on Women's Health (ALSWH 1921-1926 birth cohort. Women who responded positively to a question about CAM use in Survey 5 (2008 of the ALSWH were invited to participate in the study. A total of 13 rural and 12 urban women aged between 83 and 88 years agreed to be interviewed. Results The women expressed a range of views on CAM which fell into three broad themes: "push" factors such as dissatisfaction with conventional health services, "pull" factors which emphasised the positive aspects of choice and self-care in health matters, and barriers to CAM use. Overall, the "push' factors did not play a major role in the decision to use CAM, rather this was driven by "pull" factors related to health care self-responsibility and being able to source positive information about types of CAM. A number of barriers were identified such as access difficulties associated with increased age, limited mobility and restricted transport options, as well as financial constraints. Conclusions CAM use among older women was unlikely to be influenced by aspects of conventional health care ("push factors", but rather was reflective of the personal beliefs of the women and members of their close social networks ("pull factors". While it was also apparent that there were differences between the rural and urban women in their use of CAM, the reasons for this were mainly due to the difficulties inherent in accessing certain types of CAM in rural areas.

  16. Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

    Directory of Open Access Journals (Sweden)

    Wolf Yuri I

    2010-04-01

    Full Text Available Abstract Background Evolutionarily unrelated proteins that catalyze the same biochemical reactions are often referred to as analogous - as opposed to homologous - enzymes. The existence of numerous alternative, non-homologous enzyme isoforms presents an interesting evolutionary problem; it also complicates genome-based reconstruction of the metabolic pathways in a variety of organisms. In 1998, a systematic search for analogous enzymes resulted in the identification of 105 Enzyme Commission (EC numbers that included two or more proteins without detectable sequence similarity to each other, including 34 EC nodes where proteins were known (or predicted to have distinct structural folds, indicating independent evolutionary origins. In the past 12 years, many putative non-homologous isofunctional enzymes were identified in newly sequenced genomes. In addition, efforts in structural genomics resulted in a vastly improved structural coverage of proteomes, providing for definitive assessment of (nonhomologous relationships between proteins. Results We report the results of a comprehensive search for non-homologous isofunctional enzymes (NISE that yielded 185 EC nodes with two or more experimentally characterized - or predicted - structurally unrelated proteins. Of these NISE sets, only 74 were from the original 1998 list. Structural assignments of the NISE show over-representation of proteins with the TIM barrel fold and the nucleotide-binding Rossmann fold. From the functional perspective, the set of NISE is enriched in hydrolases, particularly carbohydrate hydrolases, and in enzymes involved in defense against oxidative stress. Conclusions These results indicate that at least some of the non-homologous isofunctional enzymes were recruited relatively recently from enzyme families that are active against related substrates and are sufficiently flexible to accommodate changes in substrate specificity. Reviewers This article was reviewed by Andrei

  17. Rapid architecture alternative modeling (RAAM): A framework for capability-based analysis of system of systems architectures

    Science.gov (United States)

    Iacobucci, Joseph V.

    The research objective for this manuscript is to develop a Rapid Architecture Alternative Modeling (RAAM) methodology to enable traceable Pre-Milestone A decision making during the conceptual phase of design of a system of systems. Rather than following current trends that place an emphasis on adding more analysis which tends to increase the complexity of the decision making problem, RAAM improves on current methods by reducing both runtime and model creation complexity. RAAM draws upon principles from computer science, system architecting, and domain specific languages to enable the automatic generation and evaluation of architecture alternatives. For example, both mission dependent and mission independent metrics are considered. Mission dependent metrics are determined by the performance of systems accomplishing a task, such as Probability of Success. In contrast, mission independent metrics, such as acquisition cost, are solely determined and influenced by the other systems in the portfolio. RAAM also leverages advances in parallel computing to significantly reduce runtime by defining executable models that are readily amendable to parallelization. This allows the use of cloud computing infrastructures such as Amazon's Elastic Compute Cloud and the PASTEC cluster operated by the Georgia Institute of Technology Research Institute (GTRI). Also, the amount of data that can be generated when fully exploring the design space can quickly exceed the typical capacity of computational resources at the analyst's disposal. To counter this, specific algorithms and techniques are employed. Streaming algorithms and recursive architecture alternative evaluation algorithms are used that reduce computer memory requirements. Lastly, a domain specific language is created to provide a reduction in the computational time of executing the system of systems models. A domain specific language is a small, usually declarative language that offers expressive power focused on a particular

  18. STEREOLOGY AND 3D MICROSCOPY: USEFUL ALTERNATIVES OR COMPETITORS IN THE QUANTITATIVE ANALYSIS OF MICROSTRUCTURES?

    Directory of Open Access Journals (Sweden)

    Hans Eckart Exner

    2011-05-01

    Full Text Available With the rapid development of modern techniques for producing 3D images, the assessment of 3D geometry from 2D sections of projections by stereological methods seems to become more and more redundant. The paper aims to show the limits of the two approaches and to outline their relative advantages in practical applications. It is concluded that, for a large variety of applications, classical stereological methods are the most effective way to characterize 3D geometry of irregular microstructures. The basic equations for useful global (field parameters are summarized and their assessment by manual techniques is indicated. For other types of applications asking for complex parameters like shape, arrangement or size distribution, preference should be given to direct 3D measurements. Parameters obtained by 2D analysis of sections or projections are useful for comparison purposes, for empirical correlation analysis or for fingerprinting-type description. Field and feature parameters and the problems of data reductions are discussed.

  19. An Empirical Analysis of Television Commercial Ratings in Alternative Competitive Environments Using Multinomial Logit Model

    Directory of Open Access Journals (Sweden)

    Dilek ALTAŞ

    2013-05-01

    Full Text Available Watching the commercials depends on the choice of the viewer. Most of the television viewing takes place during “Prime-Time” unfortunately; many viewers opt to zap to other channels when commercials start. The television viewers’ demographic characteristics may indicate the likelihood of the zapping frequency. Analysis made by using Multinomial Logit Model indicates how effective the demographic variables are in the watching rate of the first minute of the television commercials.

  20. Michel's Transport Medium as an Alternative to Liquid Nitrogen for PCR Analysis of Skin Biopsy Specimens

    OpenAIRE

    Boraiy, Logeina; Fontao, Lionel

    2014-01-01

    Formalin fixation and paraffin embedding are standard procedures for histopathological diagnosis and allow long-term archiving of tissue specimens. The cross-linking properties of formalin cause fragmentation of nucleic acids and reduce the sensitivity of PCR analysis. Michel's medium is a well-established transport medium used by dermatologists for biopsy transport to maintain tissue-fixed immunoreactants prior to direct immunofluorescence and immunoelectron microscopy. Here we report that M...

  1. Laser assisted ratio analysis - An alternative to GC/IRMS for CO2

    International Nuclear Information System (INIS)

    A new technique for laser based analysis of carbon isotope ratios, with the acronym LARA, based on large isotope shifts in molecular spectra, the use of fixed frequency isotopic lasers, and sensitive detection via the laser optogalvanic effect is reviewed and compared with GC/IRMS for carbon dioxide in specific applications. The possibility for development of new classes of isotope ratio measurement systems with LARA is explored. (author)

  2. Data-driven urban drainage analysis: An alternative to hydrodynamic models?

    OpenAIRE

    Ten Veldhuis, J.A.E.; Tait, S.J.

    2011-01-01

    In the past, there has been an emphasis on the use of hydrodynamic models as a tool for urban drainage analysis. Limited availability of monitoring data and the perceived more limited resource requirements of models led to a preference for this approach. The last decade has seen a gradual development of water quantity and quality monitoring systems through the development of reliable and increasingly cost-efficient water level sensors, continuous water quality sensors and data communication a...

  3. Techno-economic analysis of fuel cell auxiliary power units as alternative to idling

    Science.gov (United States)

    Jain, Semant; Chen, Hsieh-Yeh; Schwank, Johannes

    This paper presents a techno-economic analysis of fuel-cell-based auxiliary power units (APUs), with emphasis on applications in the trucking industry and the military. The APU system is intended to reduce the need for discretionary idling of diesel engines or gas turbines. The analysis considers the options for on-board fuel processing of diesel and compares the two leading fuel cell contenders for automotive APU applications: proton exchange membrane fuel cell and solid oxide fuel cell. As options for on-board diesel reforming, partial oxidation and auto-thermal reforming are considered. Finally, using estimated and projected efficiency data, fuel consumption patterns, capital investment, and operating costs of fuel-cell APUs, an economic evaluation of diesel-based APUs is presented, with emphasis on break-even periods as a function of fuel cost, investment cost, idling time, and idling efficiency. The analysis shows that within the range of parameters studied, there are many conditions where deployment of an SOFC-based APU is economically viable. Our analysis indicates that at an APU system cost of 100 kW -1, the economic break-even period is within 1 year for almost the entire range of conditions. At 500 kW -1 investment cost, a 2-year break-even period is possible except for the lowest end of the fuel consumption range considered. However, if the APU investment cost is 3000 kW -1, break-even would only be possible at the highest fuel consumption scenarios. For Abram tanks, even at typical land delivered fuel costs, a 2-year break-even period is possible for APU investment costs as high as 1100 kW -1.

  4. Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement.

    Science.gov (United States)

    Shatkin, J A; Ong, Kimberly J; Beaudrie, Christian; Clippinger, Amy J; Hendren, Christine Ogilvie; Haber, Lynne T; Hill, Myriam; Holden, Patricia; Kennedy, Alan J; Kim, Baram; MacDonell, Margaret; Powers, Christina M; Sharma, Monita; Sheremeta, Lorraine; Stone, Vicki; Sultan, Yasir; Turley, Audrey; White, Ronald H

    2016-08-01

    The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areas-human health, ecological health, and exposure considerations-shaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article. PMID:27510619

  5. Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration.

    Directory of Open Access Journals (Sweden)

    Devi Krishna Priya Karunakaran

    Full Text Available Age-related macular degeneration (AMD is the most common cause of blindness in the elderly population. Hypoxic stress created in the micro-environment of the photoreceptors is thought to be the underlying cause that results in the pathophysiology of AMD. However, association of AMD with alternative splicing mediated gene regulation is not well explored. Alternative Splicing is one of the primary mechanisms in humans by which fewer protein coding genes are able to generate a vast proteome. Here, we investigated the expression of a known stress response gene and an alternative splicing factor called Serine-Arginine rich splicing factor 10 (Sfrs10. Sfrs10 is a member of the serine-arginine (SR rich protein family and is 100% identical at the amino acid level in most mammals. Immunoblot analysis on retinal extracts from mouse, rat, and chicken showed a single immunoreactive band. Further, immunohistochemistry on adult mouse, rat and chicken retinae showed pan-retinal expression. However, SFRS10 was not detected in normal human retina but was observed as distinct nuclear speckles in AMD retinae. This is in agreement with previous reports that show Sfrs10 to be a stress response gene, which is upregulated under hypoxia. The difference in the expression of Sfrs10 between humans and lower mammals and the upregulation of SFRS10 in AMD is further reflected in the divergence of the promoter sequence between these species. Finally, SFRS10+ speckles were independent of the SC35+ SR protein speckles or the HSF1+ stress granules. In all, our data suggests that SFRS10 is upregulated and forms distinct stress-induced speckles and might be involved in AS of stress response genes in AMD.

  6. Critical analysis on hydrogen as an alternative to fossil fuels and biofuels for vehicles in Europe

    International Nuclear Information System (INIS)

    In recent times, the global debate on the environment has been centered on CO2 emissions. This gas is the major cause of the ''greenhouse effect'' and people are more concerned with the idea that the emissions of this gas should be minimized. As a result of this concern, the Kyoto Protocol was enacted and subscribed to by many countries, setting the maximum gas emissions for them. Fossil fuels are a major source of CO2 emissions. For some years now The European Union has been seeking to promote some years now the use of biofuels as substitutes for diesel or petrol for transport purposes. As a result of this policy, in 2003 the European Union (EU) Directive 2003/30/EC was developed with the aim of promoting the use of biofuels as a substitute for diesel or gasoline among European Union countries as well as to contribute to fulfilling the commitments acquired on climate change, security of supply in environmentally friendly conditions and the promotion of renewable energy sources. In order to achieve these goals, the directive forces all EU members to ensure that before December 31 of 2010 at least 5.75% of all gasoline and diesel fuels sold for transport purposes are biofuels. European Union countries have social and economic characteristics unique to themselves. The energy dependence on foreign sources, the features of the agricultural sector or the degree of industrialization varies greatly from one country to another. In this context, it is questionable whether the obligation imposed by this directive is actually achieving in its application uniform and/or identical goals in each of the countries involved and whether the actions of the various governments are also aligned with these goals. All these ideas were developed in a previous report (Sobrino and Monroy (2009)). This report examines the possibility of using hydrogen as an alternative to fossil fuels and biofuels from a technical, economic and environmental point of view in the specific case of a European

  7. Alternating current impedance spectroscopic analysis of biofunctionalized vertically-aligned silica nanospring surface for biosensor applications

    Science.gov (United States)

    Timalsina, Yukta P.

    In this dissertation, a process of vertically-aligned (silica) nanosprings (VANS) based biosensor development is presented. Alternating current (AC) impedance spectroscopy has been used to analyze sensor response as a function of saline phosphate (SP) buffer and biological solutions. The sensor is a parallel plate capacitor consisting of two glass substrates coated with indium tin oxide (ITO), where the VANS [or randomly-aligned nanosprings (RANS)] grown on one substrate serve as the dielectric spacer layer. The response of a VANS device as a function of ionic concentration in SP buffer was examined and an equivalent circuit model was developed. The results demonstrated that VANS sensors exhibited greater sensitivity to the changes in SP concentration relative to the ITO sensors, which serve as controls. The biofunctionalized VANS surface via physisorption and the cross-linker method demonstrates the repeatability, specificity, and selectivity of the binding. The physisorption of biotinylated immunoglobulin G (B-IgG) onto the VANS surface simplifies the whole sensing procedure for the detection of glucose oxidase, since the avidin-conjugated glucose oxidase (Av-GOx) can directly be immobilized on the B-IgG. The cross linker method involves the covalent attachment of antibodies onto the functionalized VANS surface via imine bond. The experiments revealed that the VANS sensor response is solely the result of the interaction of target molecule i.e. mouse IgG with the probe layer, i.e. goat antimouse IgG (GalphaM IgG). It was determined that VANS-based sensors exhibit a greater magnitude of change between successive bio-layers relative to the controls above 100 Hz, which indicates that the addition of biomolecules inhibits the diffusion of ions and changes the effective dielectric response of the VANS via biomolecular polarization. The study of ionic transport in nanosprings suggested that conductance follows a scaling law. It was demonstrated that a VANS-based device

  8. Application of 'C.A.R.B. financial methodology' analysis for alternative energy technologies into UK housing

    International Nuclear Information System (INIS)

    Current energy trends in UK housing are reviewed and then assessed by introducing the 'CARB financial analysis' methodology. CARB is an acronym for 'Carbon Abatement', as it evaluates the potential carbon-dioxide reduction from different technologies; 'Relative', as all the technologies examined are dependant on various primary sources; and 'Balance', as the cost of surplus CO2 is quantified. According to conventional financial analysis, most of the technologies examined have the potential to provide positive returns on the investments especially for those with an environmentally conscious agenda. Further reduction of up to 30% of most installed alternative energy systems cost is required to compete with an investment in, e.g., a UK pension scheme. Using the 'CARB financial analysis' the cost of reducing CO2 has been quantified, and compared with the potential cost of climate change impact. Conventional installed solar technologies are not financially attractive both with a pay back period calculations and 'CARB financial analysis' under current market costs and governmental subsidy regimes. Heat recovery technologies could be sensible investments, both in financial and environmental terms under particular assumptions; especially if the investment budget is small. The use of cogeneration technologies provides a financial advantage in the attempt to minimise the cost of climate change impact, as pay back period of such investment could be less than 7 yr, and the cost of CO2 saved could be two to seven times less than the global damage cost of carbon emissions. (author)

  9. Image quality assessment in digital mammography: part II. NPWE as a validated alternative for contrast detail analysis

    International Nuclear Information System (INIS)

    Assessment of image quality for digital x-ray mammography systems used in European screening programs relies mainly on contrast-detail CDMAM phantom scoring and requires the acquisition and analysis of many images in order to reduce variability in threshold detectability. Part II of this study proposes an alternative method based on the detectability index (d') calculated for a non-prewhitened model observer with an eye filter (NPWE). The detectability index was calculated from the normalized noise power spectrum and image contrast, both measured from an image of a 5 cm poly(methyl methacrylate) phantom containing a 0.2 mm thick aluminium square, and the pre-sampling modulation transfer function. This was performed as a function of air kerma at the detector for 11 different digital mammography systems. These calculated d' values were compared against threshold gold thickness (T) results measured with the CDMAM test object and against derived theoretical relationships. A simple relationship was found between T and d', as a function of detector air kerma; a linear relationship was found between d' and contrast-to-noise ratio. The values of threshold thickness used to specify acceptable performance in the European Guidelines for 0.10 and 0.25 mm diameter discs were equivalent to threshold calculated detectability indices of 1.05 and 6.30, respectively. The NPWE method is a validated alternative to CDMAM scoring for use in the image quality specification, quality control and optimization of digital x-ray systems for screening mammography.

  10. Analysis on perception of nuclear power plant and the preference of its policy alternatives for public acceptance

    International Nuclear Information System (INIS)

    Public acceptance has become an important factor in nuclear power program particularly after Chernobyl accident and recent rapid democratization in Korea. Methods reflection public opinions in order to improve public acceptance are firstly to understand what the public think about nuclear power plant and secondly to find out the public preference values for its policies. For this purpose, simplified multi-attribute utility(MAU) model was applied to analyze the public perception for five power production system. And the conjoint analysis was applied to find out he quantitative values of public preferences for twelve policy alternatives to improve the safety and support communities surrounding nuclear power plants in Korea. To implement these perception and preference analyses, mail survey was conducted to the qualified sample who had the experience of visiting nuclear power plant. Diagnosis of their perception pattern for five power production systems was made by the simplified MAU model. Estimation of the quantitative preference values for potential policy alternatives was made by the conjoint measurement technique, which made it possible to forecast the effectiveness of each option. The results from the qualified sample and the methods used in this study would be helpful to set up new policy of nuclear power plant. 4 figs., 7 tabs., 18 refs. (Author)

  11. Analysis of cost and accuracy of alternative strategies for Enterobacteriaceae identification.

    Science.gov (United States)

    Robertson, E A; Macks, G C; MacLowry, J D

    1976-04-01

    Analysis of the cost of time and material required for the diagnosis of Enterobacteriacea isolates indicated that a conventional 17-tube (20-test) setup costs $7.98 per isolated identified. Using the API 20E, a similar identification cost $3.02. A conventional 7-tube (10-test) setup cost $3.60, whereas the comparable cost by 30% while increasing the number of isolate identified correctly by 3%. Other strategres using the API 20E or a deoxyribounclease test were also evaluated for cost and accuracy. PMID:770498

  12. Appraisal of Airport Alternatives in Greenland by the use of Risk Analysis and Monte Carlo Simulation

    DEFF Research Database (Denmark)

    Salling, Kim Bang; Leleur, Steen

    2007-01-01

    construction cost and the travel time sav-ings. The obtained model results aim to provide an input to informed decision-making based on an account of the level of desired risk as concerns feasibility risks. This level is presented as the probability of obtaining at least a benefit-cost ratio of a specified......This paper presents an appraisal study of three different airport proposals in Greenland by the use of an adapted version of the Danish CBA-DK model. The assessment model is based on both a deterministic calculation by the use of conventional cost-benefit analysis and a stochastic calculation...

  13. A Cost Benefit Analysis of Two Alternative Traffic Lights Systems for the Colourful City of Zamzam

    OpenAIRE

    Machimbirike, Alexious

    2012-01-01

    ABSTRACT: Zamzam Infrastructure Bank has been approached by the country’s third largest city to finance the upgrading and expansion of its traffic lights system. Since the project is social in nature, the Bank intends to justify the borrowing on the basis of Colourful City’s ability to service the loan from its consolidated cash flows. A pre-requisite however, is the need to confirm the project’s socio-economic viability through economic cost benefit analysis. The Bank assessed and is satis...

  14. Assessment of alternate procedures for the seismic analysis of multiply supported piping systems

    International Nuclear Information System (INIS)

    When response spectrum methods are used in the seismic analysis of piping systems the response due to inertial action, the dynamic response, and the response due to the time varying differential motions of the support points (the pseudo-static response) must be determined. In this study the adequacy and the degree of conservatism associated with the uniform response spectrum method, the center of mass response spectrum method and fourteen variants of the independent response spectrum method to compute the dynamic response and five different methods to compute the pseudo-static response were evaluated. For this purpose a sample of six piping systems, two of which were subjected to thirty-three earthquakes, were studied. For each system and seismic excitation a multiple independent support excitation time history analysis was developed and used to provide a best estimate of true response and to form the basis for comparison. A combination procedure to calculate the total responses is considered as well. Results are presented and compared to the corresponding responses evaluated using the current uniform response spectrum method and the center of mass response spectra approach. Based on the results, recommendations concerning the use of the methods were developed

  15. Performance analysis of hybrid solid oxide fuel cell and gas turbine cycle: Application of alternative fuels

    International Nuclear Information System (INIS)

    Highlights: • Variation of the stream properties in the syngas-fueled hybrid SOFC–GT cycle. • Detailed analysis of the operation of the methane-fueled SOFC–GT cycle. • Investigate effects of inlet fuel type and composition on performance of cycle. • Comparison of system operation when operated with and without anode recirculation. - Abstract: In this paper, the hybrid solid oxide fuel cell (SOFC) and gas turbine (GT) model was applied to investigate the effects of the inlet fuel type and composition on the performance of the cycle. This type of analysis is vital for the real world utilization of manufactured fuels in the hybrid SOFC–GT system due to the fact that these fuel compositions depends on the type of material that is processed, the fuel production process, and process control parameters. In the first part of this paper, it is shown that the results of a limited number of studies on the utilization of non-conventional fuels have been published in the open literature. However, further studies are required in this area to investigate all aspects of the issue for different configurations and assumptions. Then, the results of the simulation of the syngas-fueled hybrid SOFC–GT cycle are employed to explain the variation of the stream properties throughout the cycle. This analysis can be very helpful in understanding cycle internal working and can provide some interesting insights to the system operation. Then, the detailed information of the operation of the methane-fueled SOFC–GT cycle is presented. For both syngas- and methane-fueled cycles, the operating conditions of the equipment are presented and compared. Moreover, the comparison of the characteristics of the system when it is operated with two different schemes to provide the required steam for the cycle, with anode recirculation and with an external source of water, provides some interesting insights to the system operation. For instance, it was shown that although the physical

  16. Direct-current arc and alternating-current spark emission spectrographic field methods for the semiquantitative analysis of geologic materials

    Science.gov (United States)

    Grimes, D.J.; Marranzino, A.P.

    1968-01-01

    Two spectrographic methods are used in mobile field laboratories of the U. S. Geological Survey. In the direct-current arc method, the ground sample is mixed with graphite powder, packed into an electrode crater, and burned to completion. Thirty elements are determined. In the spark method, the sample, ground to pass a 150-mesh screen, is digested in hydrofluoric acid followed by evaporation to dryness and dissolution in aqua regia. The solution is fed into the spark gap by means of a rotating-disk electrode arrangement and is excited with an alternating-current spark discharge. Fourteen elements are determined. In both techniques, light is recorded on Spectrum Analysis No. 1, 35-millimeter film, and the spectra are compared visually with those of standard films.

  17. SustainPro - A tool for systematic process analysis, generation and evaluation of sustainable design alternatives

    DEFF Research Database (Denmark)

    Carvalho, Ana; Matos, Henrique A.; Gani, Rafiqul

    2013-01-01

    Chemical processes are continuously facing challenges from the demands of the global market related to economics, environment and social issues. This paper presents the development of a software tool (SustainPro) and its application to chemical processes operating in batch or continuous modes. The...... software tool is based on the implementation of an extended systematic methodology for sustainable process design (Carvalho et al. 2008 and Carvalho et al. 2009). Using process information/data such as the process flowsheet, the associated mass / energy balance data and the cost data, SustainPro guides the...... user through the necessary steps according to work-flow of the implemented methodology. At the end the design alternatives, are evaluated using environmental impact assessment tools and safety indices. The extended features of the methodology incorporate Life Cycle Assessment analysis and economic...

  18. Socioeconomic effects of power marketing alternatives for the Central Valley and Washoe Projects: 2005 regional econmic impact analysis using IMPLAN

    International Nuclear Information System (INIS)

    The Western Area Power Administration (Western) was founded by the Department of Energy Organization Act of 1977 to market and transmit federal hydroelectric power in 15 western states outside the Pacific Northwest, which is served by the Bonneville Power Administration. Western is divided into four independent Customer Service Regions including the Sierra Nevada Region (Sierra Nevada), the focus of this report. The Central Valley Project (CVP) and the Washoe Project provide the primary power resources marketed by Sierra Nevada. Sierra Nevada also purchases and markets power generated by the Bonneville Power Administration, Pacific Gas and Electric (PG ampersand E), and various power pools. Sierra Nevada currently markets approximately 1,480 megawatts of power to 77 customers in northern and central California. These customers include investor-owned utilities, public utilities, government agencies, military bases, and irrigation districts. Methods and conclusions from an economic analysis are summarized concerning distributional effects of alternative actions that Sierra Nevada could take with it's new marketing plan

  19. Multimodal nested sampling: an efficient and robust alternative to MCMC methods for astronomical data analysis

    CERN Document Server

    Feroz, Farhan

    2007-01-01

    In performing a Bayesian analysis of astronomical data, two difficult problems often emerge. First, in estimating the parameters of some model for the data, the resulting posterior distribution may be multimodal or exhibit pronounced (curving) degeneracies, which can cause problems for traditional MCMC sampling methods. Second, in selecting between a set of competing models, calculation of the Bayesian evidence for each model is computationally expensive. The nested sampling method introduced by Skilling (2004), has greatly reduced the computational expense of calculating evidences and also produces posterior inferences as a by-product. This method has been applied successfully in cosmological applications by Mukherjee et al. (2006), but their implementation was efficient only for unimodal distributions without pronounced degeneracies. Shaw et al. (2007), recently introduced a clustered nested sampling method which is significantly more efficient in sampling from multimodal posteriors and also determines the ...

  20. Impact of alternative electricity generation technologies on the Scottish economy: an illustrative input-output analysis

    Energy Technology Data Exchange (ETDEWEB)

    Allan, G.; McGregor, P.G.; Swales, J.K.; Turner, K. [University of Strathclyde, Glasgow (United Kingdom)

    2007-03-15

    UK energy policy is at a critical juncture, with major changes in the electricity generation mix in prospect. In Scotland, significant reductions in electricity- generating capacity are expected as coal- and nuclear-powered stations close, and renewable technologies provide a growing share of total electricity. Despite these radical changes, there has as yet been no assessment of the likely implications for the Scottish economy. This paper explores the likely systemwide impact of these changes on aggregate and sectoral outputs and employment levels using an input-output analysis that separately identifies eight generating technologies. The results suggest the need for careful disaggregation of the electricity generation sector and emphasize the economic distinctiveness of individual generation technologies.

  1. Self-organizing neural networks--an alternative way of cluster analysis in clinical chemistry.

    Science.gov (United States)

    Reibnegger, G; Wachter, H

    1996-04-15

    Supervised learning schemes have been employed by several workers for training neural networks designed to solve clinical problems. We demonstrate that unsupervised techniques can also produce interesting and meaningful results. Using a data set on the chemical composition of milk from 22 different mammals, we demonstrate that self-organizing feature maps (Kohonen networks) as well as a modified version of error backpropagation technique yield results mimicking conventional cluster analysis. Both techniques are able to project a potentially multi-dimensional input vector onto a two-dimensional space whereby neighborhood relationships remain conserved. Thus, these techniques can be used for reducing dimensionality of complicated data sets and for enhancing comprehensibility of features hidden in the data matrix. PMID:8740573

  2. The social construction of communication climate: An analysis of at-risk students in alternative high school

    Science.gov (United States)

    Souza, Tasha Jean

    1998-12-01

    Alternative high schools affect more potential high school dropouts than any other school or program and are designed to meet the needs of students who have had difficulty in conventional schools. This study examines the communication climate and constructions of caring in an alternative school for at-risk students by using a qualitative analysis grounded in the theoretical perspective of social constructionism. Observations and interviews were conducted over a six month time period. The first two chapters provide a review of literature and a detailed account of the methods used to conduct the study. Chapter Three describes the socially constructed nature of the school and the participants and the dialectical tensions of communication climate revealed from the analysis. The six dialectical tensions of communication climate are: (1) freedom/restraint, (2) disengagement/engagement, (3) personal communication/impersonal communication, (4) disconfirmation/confirmation, (5) equality/inequality, and (6) ambiguity/clarity. Although the school climate is comprised of each of these tensions, the data suggest that the interaction within the majority of classes created some common characteristics of the general communication climate at the school and can be characterized as one of freedom, disengagement, personal communication, disconfirmation, equality, and ambiguity. Chapter Four describes how caring was constructed and communicated. Although some students perceived some teachers as caring about students and about student learning, half of the students interviewed thought they were not learning or not learning much. Finally, Chapter Five provides a summary of the findings and a discussion of the results. The results of this study contribute to an understanding of the social construction of communication climate and caring in general, and within an alternative school for at-risk students, in specific. The results contribute to the understanding of the complexity of the

  3. An alternative approach for addressing the failure probability-safety factor method with sensitivity analysis

    International Nuclear Information System (INIS)

    The paper introduces a method for solving the failure probability-safety factor problem for designing engineering works proposed by Castillo et al. that optimizes an objective function subject to the standard geometric and code constraints, and two more sets of constraints that simultaneously guarantee given safety factors and failure probability bounds associated with a given set of failure modes. The method uses the dual variables and is especially convenient to perform a sensitivity analysis, because sensitivities of the objective function and the reliability indices can be obtained with respect to all data values. To this end, the optimization problems are transformed into other equivalent ones, in which the data parameters are converted into artificial variables, and locked to their actual values. In this way, some variables of the associated dual problems become the desired sensitivities. In addition, using the proposed methodology, calibration of codes based on partial safety factors can be done. The method is illustrated by its application to the design of a simple rubble mound breakwater and a bridge crane

  4. Alternative industrial carbon emissions benchmark based on input-output analysis

    Science.gov (United States)

    Han, Mengyao; Ji, Xi

    2016-05-01

    Some problems exist in the current carbon emissions benchmark setting systems. The primary consideration for industrial carbon emissions standards highly relate to direct carbon emissions (power-related emissions) and only a portion of indirect emissions are considered in the current carbon emissions accounting processes. This practice is insufficient and may cause double counting to some extent due to mixed emission sources. To better integrate and quantify direct and indirect carbon emissions, an embodied industrial carbon emissions benchmark setting method is proposed to guide the establishment of carbon emissions benchmarks based on input-output analysis. This method attempts to link direct carbon emissions with inter-industrial economic exchanges and systematically quantifies carbon emissions embodied in total product delivery chains. The purpose of this study is to design a practical new set of embodied intensity-based benchmarks for both direct and indirect carbon emissions. Beijing, at the first level of carbon emissions trading pilot schemes in China, plays a significant role in the establishment of these schemes and is chosen as an example in this study. The newly proposed method tends to relate emissions directly to each responsibility in a practical way through the measurement of complex production and supply chains and reduce carbon emissions from their original sources. This method is expected to be developed under uncertain internal and external contexts and is further expected to be generalized to guide the establishment of industrial benchmarks for carbon emissions trading schemes in China and other countries.

  5. An alternative approach for addressing the failure probability-safety factor method with sensitivity analysis

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, Enrique; Conejo, Antonio J.; Minguez, Roberto; Castillo, Carmen

    2003-11-01

    The paper introduces a method for solving the failure probability-safety factor problem for designing engineering works proposed by Castillo et al. that optimizes an objective function subject to the standard geometric and code constraints, and two more sets of constraints that simultaneously guarantee given safety factors and failure probability bounds associated with a given set of failure modes. The method uses the dual variables and is especially convenient to perform a sensitivity analysis, because sensitivities of the objective function and the reliability indices can be obtained with respect to all data values. To this end, the optimization problems are transformed into other equivalent ones, in which the data parameters are converted into artificial variables, and locked to their actual values. In this way, some variables of the associated dual problems become the desired sensitivities. In addition, using the proposed methodology, calibration of codes based on partial safety factors can be done. The method is illustrated by its application to the design of a simple rubble mound breakwater and a bridge crane.

  6. EDIN design study alternate space shuttle booster replacement concepts. Volume 1: Engineering analysis

    Science.gov (United States)

    Demakes, P. T.; Hirsch, G. N.; Stewart, W. A.; Glatt, C. R.

    1976-01-01

    The use of a recoverable liquid rocket booster (LRB) system to replace the existing solid rocket booster (SRB) system for the shuttle was studied. Historical weight estimating relationships were developed for the LRB using Saturn technology and modified as required. Mission performance was computed using February 1975 shuttle configuration groundrules to allow reasonable comparison of the existing shuttle with the study designs. The launch trajectory was constrained to pass through both the RTLS/AOA and main engine cut off points of the shuttle reference mission 1. Performance analysis is based on a point design trajectory model which optimizes initial tilt rate and exoatmospheric pitch profile. A gravity turn was employed during the boost phase in place of the shuttle angle of attack profile. Engine throttling add/or shutdown was used to constrain dynamic pressure and/or longitudinal acceleration where necessary. Four basic configurations were investigated: a parallel burn vehicle with an F-1 engine powered LRB; a parallel burn vehicle with a high pressure engine powered LRB; a series burn vehicle with a high pressure engine powered LRB. The relative sizes of the LRB and the ET are optimized to minimize GLOW in most cases.

  7. Refinement of Stereo Image Analysis Using Photometric Shape Recovery as AN Alternative to Bundle Adjustment

    Science.gov (United States)

    Grumpe, A.; Schröer, C.; Kauffmann, S.; Fricke, T.; Wöhler, C.; Mall, U.

    2016-06-01

    Topographic mapping, e.g. the generation of Digital Elevation Models (DEM), is of general interest to the remote sensing community and scientific research. Commonly, photogrammetric methods, e.g. stereo image analysis methods (SIAM) or bundle adjustment methods (BAM), are applied to derive 3D information based on multiple images of an area. These methods require the detection of control points, i.e. common points within multiple images, which relies on a similarity measure and usually yields a sparse map of 3D points. The full spatial DEM is then obtained by interpolation techniques or imposed restrictions, e.g. smoothness constraints. Since BAM utilizes all images of the area, it is assumed to provide a more accurate DEM than SIAM which utilizes only pairs of images. Intensity-based shape recovery, e.g. shape from shading (SfS), utilizes the reflectance behavior of the object surface and thus provides a dense map of relative height changes, which provide the possibility to refine the photogrammetric DEMs. Based on Rosetta NavCam images of 67P/Churyumov-Gerasimenko we compare intensity-based DEM refinement methods which use DEMs obtained based on SIAM and BAM as a reference. We show that both the SIAM based DEM refinement and the BAM based DEM refinement are of similar quality. It is thus possible to derive DEMs of high lateral resolution by applying the intensity-based refinement to the less complex SIAM.

  8. A New Alternative in Urban Geophysics: Multi-Channel Analysis of Surface Waves (MASW) Method

    International Nuclear Information System (INIS)

    Geophysical studies are increasingly being applied to geotechnical investigations as they can identify soil properties and soil boundaries. Other advantage is that many of these methods are non-invasive and environment friendly. Soil stiffness is one of the critical material parameters considered during an early stage of most foundation construction. It is related directly to the stability of structural load, especially as it relates to possible earthquake hazard. Soil lacking sufficient stiffness for a given load can experience a significant reduction in strength under earthquake shaking resulting in liquefaction, a condition responsible for tremendous amounts of damage from earthquakes around the world The multichannel analysis of surface waves (MASW) method originated from the traditional seismic exploration approach that employs multiple (twelve or more) receivers placed along a linear survey line. Main advantage is its capability of recognizing different types of seismic waves based on wave propagation characteristics such as velocity and attenuation. The MASW method utilizes this capability to discriminate the fundamental-mode Rayleigh wave against all other types of surface and body waves generated not only from the active seismic source but also from the ambient site conditions. Dispersive characteristics of seismic waves are imaged from an objective 2-D wave field transformation. The present paper indicates results from MASW survey at different urban site in Turkey. MASW techniques will prove to be important tools for obtaining shear wave velocity and evaluating liquefaction potential, soil bearing capacity and soil amplification, etc. for future geophysical and geotechnical engineering community

  9. Reliability and availability analysis of two alternative evacuation systems designed for the Next European Torus (NET)

    International Nuclear Information System (INIS)

    This paper discusses the reliability and availability issues in case of two different evacuation system designs which have been proposed for the Next European Torus (NET). One of these designs uses turbo molecular pumps while the other employs cryogenic pumps to evacuate waste products from the torus after every fusion cycle. The aim of this paper is to assess and compare the feasibility of the above two designs form the reliability and availability point of view. A detailed failure mode analysis has been carried out for these two systems and appropriate mathematical mdoels have been developed to calculate their respective reliabilities. Using these mathematical models an extensive parameter study of the system reliability has been carried out over a given range of the component reliabilities. This parameter study shows that the maximum value of the turbo molecular pump system reliability is 96% while the corresponding value for the cryogenic pump system is only 81.6%. The target value for the system availability is 99.9%. This requires that the system mean repair time should be 48 h, appropriate modifications must be made to the turbo pump system design to increase its reliability accordingly. (author). 4 refs.; 10 figs

  10. System analysis and assessment of technological alternatives for Nordic H{sub 2} energy foresight

    Energy Technology Data Exchange (ETDEWEB)

    Koljonen, T.; Pursiheimo, E. [VTT, Espoo (Finland); Gether, K. [NTNU, Trondheim (Norway); Joergensen, K. [Risoe National Lab. (Denmark)

    2004-12-01

    The hydrogen scenarios developed during the Nordic Hydrogen Foresight project was analysed using a energy system model, which was developed during the project. The aim of the systems analysis was to analyse the technical and economical potential of hydrogen society in the Nordic countries in quantitative terms as well as the competitiveness of the selected hydrogen based systems. Visions and scenarios of the future energy systems in the Nordic area were defined in the workshops of the project. As a result of these workshops three scenarios were selected to outline the future of Nordic energy. The scenarios included different energy policies; scenarios for fossil fuel prices; and hydrogen energy demands, which varied from 6% to 18% of the total energy demand in 2030 for transport sector, and from 3% to 9% in heat and power production. In the roadmap workshops, the most important hydrogen based systems were selected, which were also included in the model. These include steam reforming of natural gas, electrolysis with renewable electricity, and biomass gasification for hydrogen production. For stationary applications, fuel cells and gas engines were selected for power and heat production. In our scenario calculations, biomass gasification and steam reforming seem to be the most competitive technologies for hydrogen production. The competitiveness of biomass gasification is greatly affected by the biomass fuel price, which is a local energy source. Electrolysis seems to be most competitive in decentralized systems, if the electricity price is low enough. For stationary applications, CHP fuel cells seem to be the most competitive in the long term, if the technological development and the decrease in investment costs follow the assumed scenario. The approximated Nordic market sizes in 2030 for the base scenarios varied from 1000 ME to 3000 MEuro for hydrogen production, from 1000 to 4000 MEuro for stationary applications and 4000 MEuro to 12.000 MEuro for hydrogen

  11. Comparative Analysis of Alternative Spectral Bands of CO2 and O2 for the Sensing of CO2 Mixing Ratios

    Science.gov (United States)

    Pliutau, Denis; Prasad, Narasimha S.

    2013-01-01

    We performed comparative studies to establish favorable spectral regions and measurement wavelength combinations in alternative bands of CO2 and O2, for the sensing of CO2 mixing ratios (XCO2) in missions such as ASCENDS. The analysis employed several simulation approaches including separate layers calculations based on pre-analyzed atmospheric data from the modern-era retrospective analysis for research and applications (MERRA), and the line-byline radiative transfer model (LBLRTM) to obtain achievable accuracy estimates as a function of altitude and for the total path over an annual span of variations in atmospheric parameters. Separate layer error estimates also allowed investigation of the uncertainties in the weighting functions at varying altitudes and atmospheric conditions. The parameters influencing the measurement accuracy were analyzed independently and included temperature sensitivity, water vapor interferences, selection of favorable weighting functions, excitations wavelength stabilities and other factors. The results were used to identify favorable spectral regions and combinations of on / off line wavelengths leading to reductions in interferences and the improved total accuracy.

  12. Battlefield Utility of Antipersonnel Landmines and Proposed Alternatives (Analysis in Support of the NATO SAS-023 APM Study)

    Energy Technology Data Exchange (ETDEWEB)

    Crandley, J F; Greenwalt, R J; Magnoli, D E; Randazzo, A S

    2002-02-05

    This study consists of work done in support of the U.S. delegation to the NATO SAS-023 Antipersonnel Landmine Study Group, supplemented by additional work done for the U.S. Office of the Secretary of Defense Antipersonnel Landmine Alternative Concept Exploration Program (Track III). It explores the battlefield utility of current antipersonnel landmines (APL) in both pure and mixed APL/antitank minefields and evaluates the value of military suggested non-materiel alternatives. The historical record is full of examples where the presence (or absence) of antipersonnel landmines made a critical difference in battle. The current generation of military thinkers and writers lack any significant combat experience employing either mixed or antipersonnel minefields, which leaves a critical gap in available expert advice for policy and decision-makers. Because of this lack of experienced-based professional military knowledge, Lawrence Livermore National Laboratory analyzed the employment of antipersonnel landmines in tactical mixed minefields and in protective antipersonnel minefields. The scientific method was employed where hypotheses were generated from the tactics and doctrine of the antipersonnel landmine era and tested in a simulation laboratory. A high-resolution, U.S. Joint Forces Command combat simulation model (the Joint Conflict and Tactical Simulation--JCATS) was used as the laboratory instrument. A realistic European scenario was obtained from a multi-national USAREUR exercise and was approved by the SAS-023 panel members. Additional scenarios were provided by U.S. CINC conferences and were based on Southwest Asia and Northeast Asia. Weapons data was obtained from the U.S. family of Joint Munitions Effectiveness Manuals. The U.S. Army Materiel Systems Analysis Agency conducted a limited verification and validation assessment of JCATS for purposes of this study.

  13. Allelic variation, alternative splicing and expression analysis of Psy1 gene in Hordeum chilense Roem. et Schult.

    Directory of Open Access Journals (Sweden)

    Cristina Rodríguez-Suárez

    Full Text Available BACKGROUND: The wild barley Hordeum chilense Roem. et Schult. is a valuable source of genes for increasing carotenoid content in wheat. Tritordeums, the amphiploids derived from durum or common wheat and H. chilense, systematically show higher values of yellow pigment colour and carotenoid content than durum wheat. Phytoene synthase 1 gene (Psy1 is considered a key step limiting the carotenoid biosynthesis, and the correlation of Psy1 transcripts accumulation and endosperm carotenoid content has been demonstrated in the main grass species. METHODOLOGY/PRINCIPAL FINDINGS: We analyze the variability of Psy1 alleles in three lines of H. chilense (H1, H7 and H16 representing the three ecotypes described in this species. Moreover, we analyze Psy1 expression in leaves and in two seed developing stages of H1 and H7, showing mRNA accumulation patterns similar to those of wheat. Finally, we identify thirty-six different transcripts forms originated by alternative splicing of the 5' UTR and/or exons 1 to 5 of Psy1 gene. Transcripts function is tested in a heterologous complementation assay, revealing that from the sixteen different predicted proteins only four types (those of 432, 370, 364 and 271 amino acids, are functional in the bacterial system. CONCLUSIONS/SIGNIFICANCE: The large number of transcripts originated by alternative splicing of Psy1, and the coexistence of functional and non functional forms, suggest a fine regulation of PSY activity in H. chilense. This work is the first analysis of H. chilense Psy1 gene and the results reported here are the bases for its potential use in carotenoid enhancement in durum wheat.

  14. Life-cycle analysis on energy consumption and GHG emission intensities of alternative vehicle fuels in China

    International Nuclear Information System (INIS)

    Highlights: ► We analyzed the life cycle energy intensity and GHG emissions of about 40 pathways of alternative vehicle fuels in China. ► Coal-based liquid fuel has higher life cycle energy intensities and first generation technology bio-fuel has relatively lower intensity. ► By 2020 electricity will have significantly lower GHG intensity and second generation technology bio-fuel will have near zero intensities. -- Abstract: Fossil energy consumption (FEC) and greenhouse gas (GHG) emission intensities of major alternative vehicle fuels (AVFs) in China are calculated and compared with conventional fuels by means of full life-cycle analysis. Currently most of the AVFs have not relatively obvious GHG emission reduction when compared to the gasoline pathway: (1) coal-based AVF has higher intensities in terms of both the FEC and GHG emissions; (2) electricity from the average Chinese grid has the GHG emission intensity similar to that of gasoline pathway although relatively lower FEC intensity; and (3) first generation technology bio-fuel has relatively lower GHG emission intensity and substantially lower FEC intensity. It is forecasted that by 2020 when still comparing to the gasoline pathway: (1) coal-based AVF will still have FEC and GHG emission intensities that are 1.5–1.8 and 1.8–2.5 time those of gasoline pathway, and the application of carbon capture and storage technology can reduce the GHG emission intensity of coal-based AVF; (2) electricity will have significantly lower GHG intensity; and (3) second generation technology bio-fuel will have near zero FEC and GHG intensities.

  15. Alternators. Experience feedback

    International Nuclear Information System (INIS)

    Study of the technical aspects of various accidents having occured on nuclear alternators operating in the French 900 MW nuclear plant unit, and the respective solutions and possibilities for application to alternators of the 1000 and 1500 MW power plants. Analysis of the accidents on CP 1 program alternators: accidents caused by vibratory fatigue (cracking of the hydraulic connection pipes of the stator winding, cracking of the hydraulic-electric connection between the stator coiling and the output terminals, cracking of the hydrogen cooler finned tubes), pollution by copper oxide of the stator winding cooling water circuit. Accidents on CP 2 alternators: accident on the shaft sealing joint, striking inside the terminal box

  16. MLAIR: a novel alternative approach to Gjedde-Patlak graphical analysis for the quantification of irreversible radiotracers

    International Nuclear Information System (INIS)

    Gjedde-Patlak graphical analysis (PGA) has commonly been used to quantify the net accumulations (Ki) of radioligands that bind or are uptaken irreversibly. However, this method has limited accuracy for some tracers which show regional time differences in terms of achieving tissue-plasma equilibria. In this study, we suggest an alternative approach (MLAIR: Multiple Linear Analysis for Irreversible Radiotracers) for the quantification of these types of tracers. Two multiple linear regression model equations were derived from differential equations of the two-tissue compartment model with irreversible binding. The first equation (MLAIR1) has a desirable feature for ordinary least square estimations because only the dependent variable CT (t) is noisy. The second equation (MLAIR2) provides Ki from direct estimates of the coefficients of independent variables without the mediation of a division operation. Computer simulations were performed to assess the statistical properties of the parameter estimations using these two methods. Dynamic PET data acquired using [11C]MeNTI, were also analyzed to assess the usefulnesses of these two methods for VOl analysis and parametric image generation. All the properties of these two methods were compared with those of PGA and NLS. In simulations, MLAIR1 provided less biased Ki estimates than the other linear methods, but showed a high uncertainty level for noisy data, whereas MLAIR2 increased the robustness of estimation in terms of variability, but at the expense of increased bias. Both methods were computationally efficient and showed good correlations with the standard NLS method. MLAIR2 parametric images showed remarkable image quality and improved statistical power for voxel-wise comparisons than PGA. The two MLAIR approaches examined were found to have several advantages over the conventional PGA method, and would be useful for the quantification of irreversible radiotracers

  17. A Quantitative Analysis of Response Elimination and Resurgence Using Rich, Lean, and Thinning Schedules of Alternative Reinforcement

    OpenAIRE

    Sweeney, Mary M.

    2012-01-01

    A common approach to the treatment of instrumental problem behavior is the introduction of an acceptable alternative source of reinforcement. However, when alternative reinforcement is removed or reduced, the target behavior tends to relapse. The relapse of a target response following the removal of alternative reinforcement has been termed resurgence. Shahan and Sweeney developed a quantitative model of resurgence based on behavioral momentum theory that captures both the disruptive and stre...

  18. Evaluation Outcomes Associated with Alternative Dosing Strategies for Piperacillin/Tazobactam: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Yang, Hui; Cui, Xiangli; Ma, Zhuo; Liu, Lihong

    2016-01-01

    A better dosing strategy can improve clinical outcomes for patients. We systematically reviewed the literatures to determine whether any clinical benefits exist for piperacillin/tazobactam by extended or continuous infusion. Methods - A search of PubMed, Web of Science, ProQuest, ScienceDirect, Cochrane, Embase and related ICAAC and ACCP conferences were conducted up to September 5, 2015. Randomized controlled and observational studies that compared extended or continuous infusion with conventional intermittent infusion of piperacillin/tazobactam were identified from the databases above and analyzed. Two reviewers independently evaluated the methodology and extracted data from primary studies. A meta-analysis was performed using Revman 5.2 software. The quality of each study was assessed. Sensitivity analysis and publication bias were evaluated. Results - Three randomized controlled trials and twelve observational studies were included in this study. All included studies had high quality and no publication bias was found. Compared to the conventional intermittent infusion approach, the extended or continuous infusion group had a significant cost effectiveness (OR -0.89.02, CI (-114.69,-63.35), P<0.00001). No statistical difference was observed for clinical cure rate (OR 1.64, 95% CI (0.88, 3.30), P=0.12) between the two dosing regimens. The sensitivity analysis showed the results were stable. Conclusions - Our systematic review and meta-analysis found that the outcomes associated with alternative dosing strategies of piperacillin/tazobactam have changed compared with conclusions before for several literatures with large samples published. Further data on the outcomes should be generated for a better understanding of the extended or continuous infusion strategy. On the whole, our meta-analysis suggested that the extended or continuous infusion should be recommended for clinical use only considering its economic advantage, but there was no significantly higher

  19. Socioeconomic effects of power marketing alternatives for the Central Valley and Washoe Projects: 2005 regional econmic impact analysis using IMPLAN

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, D.M.; Godoy-Kain, P.; Gu, A.Y.; Ulibarri, C.A.

    1996-11-01

    The Western Area Power Administration (Western) was founded by the Department of Energy Organization Act of 1977 to market and transmit federal hydroelectric power in 15 western states outside the Pacific Northwest, which is served by the Bonneville Power Administration. Western is divided into four independent Customer Service Regions including the Sierra Nevada Region (Sierra Nevada), the focus of this report. The Central Valley Project (CVP) and the Washoe Project provide the primary power resources marketed by Sierra Nevada. Sierra Nevada also purchases and markets power generated by the Bonneville Power Administration, Pacific Gas and Electric (PG&E), and various power pools. Sierra Nevada currently markets approximately 1,480 megawatts of power to 77 customers in northern and central California. These customers include investor-owned utilities, public utilities, government agencies, military bases, and irrigation districts. Methods and conclusions from an economic analysis are summarized concerning distributional effects of alternative actions that Sierra Nevada could take with it`s new marketing plan.

  20. A Comparison of Wind Energy Investment Alternatives Using Interval-Valued Intuitionistic Fuzzy Benefit/Cost Analysis

    Directory of Open Access Journals (Sweden)

    Cengiz Kahraman

    2016-01-01

    Full Text Available One of the tools for maintaining environmental sustainability is transformation from fossil-based energy sources to renewable energy sources in energy consumption. Among renewable energy alternatives, wind energy is the most prominent and reliable energy source for fulfilling energy demand. Traditional investment evaluation techniques based on discounted cash flows are not capable of capturing the uncertainty and vagueness in the data related to the wind energy investment parameters. Fuzzy capital budgeting techniques can capture this vagueness and model the imprecise estimations of parameter values. In this paper, we develop interval-valued intuitionistic fuzzy benefit-cost analysis for the evaluation of wind energy technology investments. The fuzzy benefit-cost analyses are based on both present worth and annual worth analyses. The developed analyses can handle the assessments of multiple experts through aggregation operators. In the proposed economic model, the components of each wind energy investment parameter are incorporated into the equations in detail. A real case study is also presented in this paper.

  1. Cost-benefit analysis of retrofit of high-intensity discharge factory lighting with energy-saving alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Preston, D.J. [Alabama Industrial Assessment Center, The University of Alabama, 1530 W. Tremont St, Allentown, PA 18102 (United States); Woodbury, K.A. [Alabama Industrial Assessment Center, The University of Alabama, 290 Hardaway Hall, Box 870276, Tuscaloosa, AL 35487-0276 (United States)

    2013-05-15

    Due to increased concern about overall energy costs and the appearance of efficient and inexpensive lighting system alternatives, factories and plants with high-intensity discharge (HID) lighting are forced to consider retrofit with more modern, energy-efficient lighting. The decision is complicated from an economic perspective, and there is a lack of information readily available on the topic. This study provides an analysis of the replacement by retrofit of common probe-start metal halide and high-pressure sodium industrial lighting systems. Retrofit options considered include the more recent pulse-start metal halide lamps and a range of T5 high output and T8 fluorescent lamp configurations. Recent data on lighting system pricing, labor and energy costs, and time required for tasks are reported. The results generated include savings, payback period, and net present value for many retrofit options, as well as the change in energy consumption, carbon footprint, and lumen output for each retrofit. Effects of varying rate of return and daily duration of operation are considered. Based on change in lumen output, payback period, net present value, and comparison of lighting quality, one or two options are recommended from the overall retrofit options considered. A fluorescent retrofit is recommended for each of the HID initial scenarios considered. The payback period is no more than 3 years in any recommended case. The focus of this study is on the potential energy and cost savings, and some proposed solutions may, or may not, be acceptable due to lack of illuminance uniformity.

  2. A multi-attribute utility decision analysis for treatment alternatives for the DOE/SR aluminum-based spent nuclear fuel

    International Nuclear Information System (INIS)

    A multi-attribute utility analysis is applied to a decision process to select a treatment method for the management of aluminum-based spent nuclear fuel (Al-SNF) owned by the US Department of Energy (DOE). DOE will receive, treat, and temporarily store Al-SNF, most of which is composed of highly enriched uranium, at its Savannah River Site in South Carolina. DOE intends ultimately to send the treated Al-SNF to a geologic repository for permanent disposal. DOE initially considered ten treatment alternatives for the management of Al-SNF, and has narrowed the choice to two of these: the direct disposal and melt and dilute alternatives. The decision analysis presented in this document focuses on a formal decision process used to evaluate these two remaining alternatives

  3. A Multi-Attribute Utility Decision Analysis for Treatment Alternatives for the DOE/SR Aluminum-Based Spent Nuclear Fuel

    International Nuclear Information System (INIS)

    A multi-attribute utility analysis is applied to a decision process to select a treatment method for the management of aluminum-based spent nuclear fuel (Al-SNF) owned by the US Department of Energy (DOE). DOE will receive, treat, and temporarily store Al-SNF, most of which is composed of highly enriched uranium, at its Savannah River Site in South Carolina. DOE intends ultimately to send the treated Al-SNF to a geologic repository for permanent disposal. DOE initially considered ten treatment alternatives for the management of Al-SNF, and has narrowed the choice to two of these: the direct disposal and melt and dilute alternatives. The decision analysis presented in this document focuses on a formal decision process used to evaluate these two remaining alternatives

  4. Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2.

    Science.gov (United States)

    Simon, Lukas M; Chen, Edward S; Edelstein, Leonard C; Kong, Xianguo; Bhatlekar, Seema; Rigoutsos, Isidore; Bray, Paul F; Shaw, Chad A

    2016-05-01

    Platelets play a central role in ischemic cardiovascular events. Cardiovascular disease (CVD) is a major cause of death worldwide. Numerous genome-wide association studies (GWASs) have identified loci associated with CVD risk. However, our understanding of how these variants contribute to disease is limited. Using data from the platelet RNA and expression 1 (PRAX1) study, we analyzed cis expression quantitative trait loci (eQTLs) in platelets from 154 normal human subjects. We confirmed these results in silico by performing allele-specific expression (ASE) analysis, which demonstrated that the allelic directionality of eQTLs and ASE patterns correlate significantly. Comparison of platelet eQTLs with data from the Genotype-Tissue Expression (GTEx) project revealed that a number of platelet eQTLs are platelet specific and that platelet eQTL peaks localize to the gene body at a higher rate than eQTLs from other tissues. Upon integration with data from previously published GWASs, we found that the trait-associated variant rs1474868 coincides with the eQTL peak for mitofusin 2 (MFN2). Additional experimental and computational analyses revealed that this eQTL is linked to an unannotated alternate MFN2 start site preferentially expressed in platelets. Integration of phenotype data from the PRAX1 study showed that MFN2 expression levels were significantly associated with platelet count. This study links the variant rs1474868 to a platelet-specific regulatory role for MFN2 and demonstrates the utility of integrating multi-omic data with eQTL analysis in disease-relevant tissues for interpreting GWAS results. PMID:27132591

  5. Dissecting an alternative splicing analysis workflow for GeneChip® Exon 1.0 ST Affymetrix arrays

    Directory of Open Access Journals (Sweden)

    Calogero Raffaele A

    2008-11-01

    Full Text Available Abstract Background A new microarray platform (GeneChip® Exon 1.0 ST has recently been developed by Affymetrix http://www.affymetrix.com. This microarray platform changes the conventional view of transcript analysis since it allows the evaluation of the expression level of a transcript by querying each exon component. The Exon 1.0 ST platform does however raise some issues regarding the approaches to be used in identifying genome-wide alternative splicing events (ASEs. In this study an exon-level data analysis workflow is dissected in order to detect limit and strength of each step, thus modifying the overall workflow and thereby optimizing the detection of ASEs. Results This study was carried out using a semi-synthetic exon-skipping benchmark experiment embedding a total of 268 exon skipping events. Our results point out that summarization methods (RMA, PLIER do not affect the efficacy of statistical tools in detecting ASEs. However, data pre-filtering is mandatory if the detected number of false ASEs are to be reduced. MiDAS and Rank Product methods efficiently detect true ASEs but they suffer from the lack of multiple test error correction. The intersection of MiDAS and Rank Product results efficiently moderates the detection of false ASEs. Conclusion To optimize the detection of ASEs we propose the following workflow: i data pre-filtering, ii statistical selection of ASEs using both MiDAS and Rank Product, iii intersection of results derived from the two statistical analyses in order to moderate family-wise errors (FWER.

  6. Analysis of an alternative method for the study of bromeliad-associated fauna in plants with different foliar organization

    OpenAIRE

    Gerson A. Müller; Fernando T. Name; Frederico C.L. Pacheco; Carlos B. Marcondes

    2010-01-01

    The efficiency of an alternative method of collection (by suction of water) for the study of Culicidae and Chironomidae (Diptera), Scirtidae (Coleoptera) and Coenagrionidae (Odonata) in bromeliads with different foliar architecture in a restinga at Florianópolis, SC, Brazil, was studied. The alternative method was less efficient to collect Culicidae and Chironomidae (Wilcoxon test p 0.05) from Aechmea lindenii. ...

  7. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    This NASAP assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improvng the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness

  8. Alternative Treatments

    Science.gov (United States)

    ... Find your chapter: search by state Home > Alzheimer's Disease > Treatments > Alternative Treatments Overview What Is Dementia? What Is Alzheimer's? Younger/Early Onset Facts and Figures Know the 10 Signs Stages Inside the Brain: ...

  9. Nucleotide sequence and mutational analysis of the structural genes (anfHDGK) for the second alternative nitrogenase from Azotobacter vinelandii.

    Science.gov (United States)

    Joerger, R D; Jacobson, M R; Premakumar, R; Wolfinger, E D; Bishop, P E

    1989-02-01

    The nucleotide sequence of a region of the Azotobacter vinelandii genome exhibiting sequence similarity to nifH has been determined. The order of open reading frames within this 6.1-kilobase-pair region was found to be anfH (alternative nitrogen fixation, nifH-like gene), anfD (nifD-like gene), anfG (potentially encoding a protein similar to the product of vnfG from Azotobacter chroococcum), anfK (nifK-like gene), followed by two additional open reading frames. The 5'-flanking region of anfH contains a nif promoter similar to that found in the A. vinelandii nifHDK gene cluster. The presumed products of anfH, anfD, and anfK are similar in predicted Mr and pI to the previously described subunits of nitrogenase 3. Deletion plus insertion mutations introduced into the anfHDGK region of wild-type strain A. vinelandii CA resulted in mutant strains that were unable to grow in Mo-deficient, N-free medium but grew in the presence of 1 microM Na2MoO4 or V2O5. Introduction of the same mutations into the nifHDK deletion strain CA11 resulted in strains that grew under diazotrophic conditions only in the presence of vanadium. The lack of nitrogenase 3 subunits in these mutant strains was demonstrated through two-dimensional gel analysis of protein extracts from cells derepressed for nitrogenase under Mo and V deficiency. These results indicate that anfH, anfD, and anfK encode structural proteins for nitrogenase 3. PMID:2644222

  10. Low cost quantitative digital imaging as an alternative to qualitative in vivo bioassays for analysis of active aflatoxin B1.

    Science.gov (United States)

    Rasooly, Reuven; Do, Paula M; Hernlem, Bradley J

    2016-06-15

    Aflatoxin B1 (AFB1) producing fungi contaminate food and feed and are a major health concern. To minimize the sources and incidence of AFB1 illness there is a need to develop affordable, sensitive mobile devices for detection of active AFB1. In the present study we used a low cost fluorescence detector and describe two quantitative assays for detection of detoxified and active AFB1 demonstrating that AFB1 concentration can be measured as intensity of fluorescence. When the assay plate containing increasing concentrations of AFB1 is illuminated with a 366nm ultraviolet lamp, AFB1 molecules absorb photons and emit blue light with peak wavelength of 432nm. The fluorescence intensity increased in dose dependent manner. However, this method cannot distinguish between active AFB1 which poses a threat to health, and the detoxified AFB1 which exhibits no toxicity. To measure the toxin activity, we used a cell based assay that makes quantification more robust and is capable of detecting multiple samples simultaneously. It is an alternative to the qualitative duckling bioassay which is the "gold-standard" assay currently being used for quantitative analysis of active AFB1. AFB1 was incubated with transduced Vero cells expressing the green fluorescence protein (GFP) gene. After excitation with blue light at 475nm, cells emitted green light with emission peak at 509nm. The result shows that AFB1 inhibits protein expression in a concentration dependent manner resulting in proportionately less GFP fluorescence in cells exposed to AFB1. The result also indicates strong positive linear relationship with R(2)=0.90 between the low cost CCD camera and a fluorometer, which costs 100 times more than a CCD camera. This new analytical method for measuring active AFB1 is low in cost and combined with in vitro assay, is quantitative. It also does not require the use of animals and may be useful especially for laboratories in regions with limited resources. PMID:26874107

  11. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    This assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improving the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness. The objectives of this assessment are to identify when economic incentives to deploy advanced nuclear power systems might exist, to estimate the costs of using technologies that would reduce the risk of proliferation, to assess the impact of major economic uncertainties on the transition to new technologies, and to compare the investments required for alternative systems. This information can then be used to assess the potential economic benefits of alternative research, development, and demonstration programs and the timing of those programs

  12. Individual Characteristics and Stated Preferences for Alternative Energy Sources and Propulsion Technologies in Vehicles: A Discrete Choice Analysis

    OpenAIRE

    Andreas R. Ziegler

    2010-01-01

    This paper empirically examines the determinants of the demand for alternative energy sources and propulsion technologies in vehicles. The data stem from a stated preference discrete choice experiment with 598 potential car buyers. In order to simulate a realistic automobile purchase situation, seven alternatives were incorporated in each of the six choice sets, i.e. hybrid, gas, biofuel, hydrogen, and electric as well as the common fuels gasoline and diesel. The vehicle types were additional...

  13. ALTERNATIVE FUELS FOR DIESEL ENGINES

    Directory of Open Access Journals (Sweden)

    Jacek Caban

    2013-12-01

    Full Text Available This paper presents the development and genesis of the use of alternative fuels in internal combustion ignition engines. Based on the analysis of the literature, this article shows various alternative fuels used in Poland and all over the world. Furthermore, this article describes the research directions for alternative fuels use in road transport powered by diesel engines.

  14. ALTERNATIVE FUELS FOR DIESEL ENGINES

    OpenAIRE

    Jacek Caban; Agata Gniecka; Lukáš Holeša

    2013-01-01

    This paper presents the development and genesis of the use of alternative fuels in internal combustion ignition engines. Based on the analysis of the literature, this article shows various alternative fuels used in Poland and all over the world. Furthermore, this article describes the research directions for alternative fuels use in road transport powered by diesel engines.

  15. Cosmic alternatives?

    Science.gov (United States)

    Gregory, Ruth

    2009-04-01

    "Cosmologists are often in error but never in doubt." This pithy characterization by the Soviet physicist Lev Landau sums up the raison d'être of Facts and Speculations in Cosmology. Authors Jayant Narlikar and Geoffrey Burbidge are proponents of a "steady state" theory of cosmology, and they argue that the cosmological community has become fixated on a "Big Bang" dogma, suppressing alternative viewpoints. This book very much does what it says on the tin: it sets out what is known in cosmology, and puts forward the authors' point of view on an alternative to the Big Bang.

  16. Profiling the Australian Consumer of Complementary and Alternative Medicine: A Secondary Analysis of National Health Survey Data.

    Science.gov (United States)

    Leach, Matthew J

    2016-07-01

    Background • Consumers' interest in complementary and alternative medicine (CAM) has escalated in the past few decades. Some observers argue that the changing needs and expectations of consumers are driving the surge. Although some studies support that notion, much of the research has been limited methodologically. Profiling can provide important insights into the distinct needs of CAM consumers. Objective • The study intended to profile consumers of CAM in Australia. Design • The study was a secondary analysis of 5 Australian National Health Surveys conducted between 1989 and 2008. Outcome Measures • The study measured the differences between CAM users and nonusers in terms of: (1) predisposing factors (ie, the prevailing conditions that predispose an individual to use a health service, such as age); (2) enabling factors (ie, circumstances that facilitate or hinder health service use, such as income); (3) need factors (ie, an actual or perceived need for health services, such as poor health); and (4) personal health practices (ie, behaviors that influence health status, such as alcohol consumption). Results • The 5 surveys provided data for 181 549 Australian adults and children. Predisposing factors associated with CAM use were (1) being aged >40 y, (2) being female, (3) being married, and (4) holding a postsecondary school qualification. Significant enablers of CAM use were (1) high income, (2) private health insurance, and (3) employment. As for personal health practices, CAM users had significantly higher odds of (1) being physically active, (2) being a nonsmoker, and (3) meeting national recommendations for intake of fruits and vegetables. The prevalence of chronic disease and the use of pharmaceutical agents and health services were comparatively high among CAM users. Conclusions • CAM consumers reported relatively healthier lifestyles compared with nonusers, although some data indicated that CAM users might have greater health care needs. The

  17. Growing Alternatives

    DEFF Research Database (Denmark)

    Bagger-Petersen, Mai Corlin

    2014-01-01

    From 2014, Anhui Province will pilot a reform of the residential land market in China, thus integrating rural Anhui in the national housing market. In contrast, artist and activist Ou Ning has proposed the Bishan time money currency, intending to establish an alternative economic circuit in Bishan...

  18. An economic analysis of alternative fertility control and associated management techniques for three BLM wild horse herds

    Science.gov (United States)

    Bartholow, John M.

    2004-01-01

    Contemporary cost projections were computed for several alternative strategies that could be used by BLM to manage three wild horse populations. The alternatives included existing gather and selective removal methods, combined with potential contraceptive applications of varying duration and other potentially useful management techniques. Costs were projected for a 20-year economic life using the Jenkins wild horse population model and cost estimates from BLM that reflect state-by-state per horse removal, adoption, long-term holding, and contraceptive application expenses. Important findings include: Application of currently available 2-year contraceptives appears capable of reducing variable operating costs for wild horse populations by about 21% on average.

  19. Alternative cropping systems can have contrasting effects on various soil-borne diseases : relevance of a systemic analysis in vegetable cropping systems

    OpenAIRE

    Collange, B.; M Navarrete; Montfort, F.; Mateille, Thierry; Tavoillot, Johannes; Martiny, Bernard; Tchamitchian, M.

    2014-01-01

    Vegetable production makes an intensive use of pesticides, and a major challenge is to build alternative cropping systems that can control pests and diseases with fewer uses of chemical products. An on-farm analysis was conducted in Southeast France to assess the efficacy of several cropping systems in simultaneously controlling two major pests: root-knot nematodes (Meloidogyne spp.) and lettuce drop due to Sclerotinia sclerotiorum. Ten cropping systems resulting from the combinations of thre...

  20. Response of Syngonium podophyllum L. ‘White Butterfly’ shoot cultures to alternative media additives and gelling agents, and flow cytometric analysis of regenerants

    OpenAIRE

    JAIME A. TEIXEIRA DA SILVA

    2015-01-01

    Abstract. Teixeira da Silva JA. 2015. Response of Syngonium podophyllum L. ‘White Butterfly’ shoot cultures to alternative media additives and gelling agents, and flow cytometric analysis of regenerants. Nusantara Bioscience 7: 26-32. Syngonium podophyllum L. (arrowhead vine) is a popular leafy indoor pot plant whose tissue culture has been established, primarily through in vitro shoot culture, but several interesting aspects have not yet been explored. In this study, cv. ‘White Butterfly’ wa...

  1. 78 FR 53187 - Early Scoping Notification for the Alternatives Analysis of the GA 400 Transit Initiative in...

    Science.gov (United States)

    2013-08-28

    ... that offers an alternative to automobile travel. This notice invites the public and agency officials to... opportunities for written comments. Written or electronic scoping comments are requested by October 28, 2013... offered at the early scoping meeting. ADDRESSES: Written or electronic comments should be sent to...

  2. 75 FR 32295 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe...

    Science.gov (United States)

    2010-06-08

    ..., 2009, Federal Register notice (74 FR 57908) (USEPA 2009b). The corrected tables are titled: Alternative... methods approval process in an April 10, 2007, Federal Register notice (72 FR 17902) (USEPA 2007) and..., Federal Register notice (73 FR 31616) (USEPA 2008) and added appendix A to 40 CFR part 141, subpart...

  3. Immobilized High Level Waste (HLW) Interim Storage Alternative Generation and analysis and Decision Report 2nd Generation Implementing Architecture

    Energy Technology Data Exchange (ETDEWEB)

    CALMUS, R.B.

    2000-09-14

    Two alternative approaches were previously identified to provide second-generation interim storage of Immobilized High-Level Waste (IHLW). One approach was retrofit modification of the Fuel and Materials Examination Facility (FMEF) to accommodate IHLW. The results of the evaluation of the FMEF as the second-generation IHLW interim storage facility and subsequent decision process are provided in this document.

  4. Risk-based decision analysis of atmospheric emission alternatives to reduce ground water degradation on the European scale

    NARCIS (Netherlands)

    Wladis, D.; Rosen, L.; Kros, H.

    1999-01-01

    Environmental degradation due to emissions of sulfur dioxide, nitrate oxides, and ammonia from diffuse sources amounts to substantial costs to society and so do the alternatives to protect and restore the environment. Damage to ground water includes acidification, aluminum leaching, elevated concent

  5. Alternative 23

    OpenAIRE

    Jackson, Mark

    2014-01-01

    Alternative 23 is a curated exhibition of works by Steve Aylett, David Blandy & Daniel Locke, Let Me Feel Your Finger First, Laura Oldfield Ford, Plastique Fantastique and Henrik Schrat, including the first screening of Let Me Feel Your Finger First’s Postcolonial Capers. In 1985 DC Comics in the US had taken the commercial decision to unify the complex and contradictory character story arcs from its various strips such as Superman, Batman and Green Lantern. The resultant crossover series...

  6. Orion Project: Alternate Attitude Study

    Science.gov (United States)

    Alvarez-Hernandez, A.; Miller, Stephen W.

    2009-01-01

    This slide presentation reviews the study done on alternate attitudes for the Orion project's crew exploration vehicle. The analysis focused on the thermal performance of the vehicle with the alternate attitudes. The pressure vessel heater power, other vehicle heaters and radiator sink temperatures were included in the analysis.

  7. Analysis of energy cogeneration with alternative motors in a brewery; Analise de cogeracao de energia com motores alternativos em uma cervejaria

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Evelyn Ramiro; Almeida Silvio Carlos Anibal de [Universidade Federal do Rio de Janeiro (DEM/UFRJ), RJ (Brazil). Dept. de Engenharia Mecanica], E-mail: eng_evelyn@poli.ufrj.br

    2010-07-01

    In this study it will be presented a technical-economical simulation on a plant that needs thermal and electrical energy, simultaneously. This simulation analysis will be based on the economical and technical validity of the installation of a thermo electrical cogeneration power plant using alternative motors. The objective intends the electrical autonomy of use of thermal energy and the better plant efficiency, and lower CO{sub 2} emissions. This analysis will utilize the Cogeneration Read Reckoner, version 3.1 of the Sinclair Knight Merz.

  8. Molecular Analysis of Alternative Transcripts of the Equine Cordon-Bleu WH2 Repeat Protein-Like 1 (COBLL1) Gene.

    Science.gov (United States)

    Park, Jeong-Woong; Jang, Hyun-Jun; Shin, Sangsu; Cho, Hyun-Woo; Choi, Jae-Young; Kim, Nam-Young; Lee, Hak-Kyo; Do, Kyong-Tak; Song, Ki-Duk; Cho, Byung-Wook

    2015-06-01

    The purpose of this study was to investigate the alternative splicing in equine cordon-bleu WH2 repeat protein-like 1 (COBLL1) gene that was identified in horse muscle and blood leukocytes, and to predict functional consequences of alternative splicing by bioinformatics analysis. In a previous study, RNA-seq analysis predicted the presence of alternative spliced isoforms of equine COBLL1, namely COBLL1a as a long form and COBLL1b as a short form. In this study, we validated two isoforms of COBLL1 transcripts in horse tissues by the real-time polymerase chain reaction, and cloned them for Sanger sequencing. The sequencing results showed that the alternative splicing occurs at exon 9. Prediction of protein structure of these isoforms revealed three putative phosphorylation sites at the amino acid sequences encoded in exon 9, which is deleted in COBLL1b. In expression analysis, it was found that COBLL1b was expressed ubiquitously and equivalently in all the analyzed tissues, whereas COBLL1a showed strong expression in kidney, spinal cord and lung, moderate expression in heart and skeletal muscle, and low expression in thyroid and colon. In muscle, both COBLL1a and COBLL1b expression decreased after exercise. It is assumed that the regulation of COBLL1 expression may be important for regulating glucose level or switching of energy source, possibly through an insulin signaling pathway, in muscle after exercise. Further study is warranted to reveal the functional importance of COBLL1 on athletic performance in race horses. PMID:25925064

  9. Elimination of Whole Effluent Toxicity NPDES Permit Limits through the Use of an Alternative Testing Species and Reasonable Potential Analysis

    International Nuclear Information System (INIS)

    The cladoceran, Ceriodaphnia dubia (C. dubia), is required by the State of South Carolina to be used in whole effluent toxicity (WET) compliance tests in order to meet limits contained within National Pollutant Discharge Elimination System (NPDES) permits. Westinghouse Savannah River Company (WSRC) experienced WET test failures for no clear reason over a long period of time. Toxicity identification examinations on effluents did not indicate the presence of toxicants; therefore, the WET test itself was brought under suspicion. Research was undertaken with an alternate cladoceran, Daphnia ambigua (D. ambigua). It was determined that this species survives better in soft water, so approval was obtained from regulating authorities to use this ''alternate'' species in WET tests. The result was better test results and elimination of non-compliances. The successful use of D. ambigua allowed WSRC to gain approval from the South Carolina Department of Health and Environmental Control (SCDHEC) to remove WET limits from the NPDES permit

  10. Evaluation of Electronic Commerce (E-Commerce) with SWOT Analysis as an Alternative Network Marketing at Agricultural Marketing

    OpenAIRE

    Nuray Kızılaslan; Tayfur Ünal

    2015-01-01

    Compulsory competition occurring in the world trade has led the enterprises to different marketing system. Marketing problems seems to be a problem in Turkey rather than agricultural production problems. In this aspect, marketing alternatives are sought. E-commerce is a system with more opportunities in agricultural marketing. Increasing the applicability of this system in Turkey will eliminate many problems associated with marketing in agriculture. With an active use of E-commerce in agricul...

  11. A Comparison of Wind Energy Investment Alternatives Using Interval-Valued Intuitionistic Fuzzy Benefit/Cost Analysis

    OpenAIRE

    Cengiz Kahraman; Sezi Cevik Onar; Basar Oztaysi

    2016-01-01

    One of the tools for maintaining environmental sustainability is transformation from fossil-based energy sources to renewable energy sources in energy consumption. Among renewable energy alternatives, wind energy is the most prominent and reliable energy source for fulfilling energy demand. Traditional investment evaluation techniques based on discounted cash flows are not capable of capturing the uncertainty and vagueness in the data related to the wind energy investment parameters. Fuzzy ca...

  12. Analysis of an alternative method for the study of bromeliad-associated fauna in plants with different foliar organization.

    Science.gov (United States)

    Müller, Gerson A; Name, Fernando T; Pacheco, Frederico C L; Marcondes, Carlos B

    2010-12-01

    The efficiency of an alternative method of collection (by suction of water) for the study of Culicidae and Chironomidae (Diptera), Scirtidae (Coleoptera) and Coenagrionidae (Odonata) in bromeliads with different foliar architecture in a restinga at Florianópolis, SC, Brazil, was studied. The alternative method was less efficient to collect Culicidae and Chironomidae (Wilcoxon test p 0.05) from Aechmea lindenii. This method was less efficient to collect insects of all groups from Vriesea friburgensis (Wilcoxon test p < 0.05). The alternative method was efficient to estimate the diversity of these insects in both species of bromeliads. The higher mobility of immature forms of beetles and dragonflies, and the availability of only one tank in Aechea lindenii, contrasting to several tanks in Vriesea friburgensis that help the suction of these immature, probably influenced the results, which indicated that the suction method should not replace the dismantling in the study of Culicidae and Chironomidae. This method can be useful to get immature forms of Scirtidae and Coenagrionidae in one-tank bromeliads. PMID:21152764

  13. Energy alternatives

    International Nuclear Information System (INIS)

    Due to sharp rise in oil proces after the 1973 Arab-Israeli War, world attention has been focussed on the energy problem. At present the energy problem is limited to the cost and reliability of supply, even though there are enough supplies to go round. However, in the future the problem will be of availability, because in spite of the full exploitation of currently available conventional energy sources, the supply will fall short of demand which will always be increasing. Hence, there is need to develop alternate energy sources, including fast breeder reactors, fusion reactors and MHD. Economic and technical aspects of these energy are discussed. (M.G.B.)

  14. Alternative detente

    International Nuclear Information System (INIS)

    The influence of the Chernobyl accident on the disarmament and anti-nuclear movements is discussed. The accident directed attention towards the areas in common rather than the areas of disagreement. It also demonstrated the environmental impact of radioactivity, strengthening the ecological case of the anti-nuclear movement. The issues are discussed for the Western and Eastern bloc countries and the relationship between the two. Sections focus on the Eco-protest, Green politics and economics and on the politics of minority protest and the Green alternative. (U.K.)

  15. Alternative crops

    International Nuclear Information System (INIS)

    Surplus cereal production in the EEC and decreasing product prices, mainly for cereals, has prompted considerable interest for new earnings in arable farming. The objective was to examine whether suggested new crops (fibre, oil, medicinal and alternative grains crops) could be considered as real alternatives. Whether a specific crop can compete economically with cereals and whether there is a market demand for the crop is analyzed. The described possibilities will result in ca. 50,000 hectares of new crops. It is expected that they would not immediately provide increased earnings, but in the long run expected price developments are more positive than for cereals. The area for new crops will not solve the current surplus cereal problem as the area used for new crops is only 3% of that used for cereals. Preconditions for many new crops is further research activities and development work as well as the establishment of processing units and organizational initiatives. Presumably, it is stated, there will then be a basis for a profitable production of new crops for some farmers. (AB) (47 refs.)

  16. Nucleotide sequence and mutational analysis of the structural genes (anfHDGK) for the second alternative nitrogenase from Azotobacter vinelandii.

    OpenAIRE

    Joerger, R D; Jacobson, M R; Premakumar, R; Wolfinger, E D; Bishop, P E

    1989-01-01

    The nucleotide sequence of a region of the Azotobacter vinelandii genome exhibiting sequence similarity to nifH has been determined. The order of open reading frames within this 6.1-kilobase-pair region was found to be anfH (alternative nitrogen fixation, nifH-like gene), anfD (nifD-like gene), anfG (potentially encoding a protein similar to the product of vnfG from Azotobacter chroococcum), anfK (nifK-like gene), followed by two additional open reading frames. The 5'-flanking region of anfH ...

  17. A painless solution? An analysis of two alternatives for global taxation for financing climate activities under the United Nations umbrella

    OpenAIRE

    Selrod, Rolf

    1995-01-01

    It is a widely held perception that the UN is unable to challenge the increasing number of global issues due to the lack of funding. Consequently, there has for some time, been a discussion of alternative ways of financing UN activities. This is also the case for activities under the UN Framework Convention on Climate Change. The level of global efforts to reduce greenhouse gas emissions is lower than the declared willingness of many countries to invest in such actions. Given this point o...

  18. Scenario analysis on alternative fuel/vehicle for China's future road transport: Life-cycle energy demand and GHG emissions

    International Nuclear Information System (INIS)

    The rapid growth of vehicles has resulted in continuing growth in China's oil demand. This paper analyzes future trends of both direct and life cycle energy demand (ED) and greenhouse gas (GHG) emissions in China's road transport sector, and assesses the effectiveness of possible reduction measures by using alternative vehicles/fuels. A model is developed to derive a historical trend and to project future trends. The government is assumed to do nothing additional in the future to influence the long-term trends in the business as usual (BAU) scenario. Four specific scenarios are used to describe the future cases where different alternative fuel/vehicles are applied. The best case scenario is set to represent the most optimized case. Direct ED and GHG emissions would reach 734 million tonnes of oil equivalent and 2384 million tonnes carbon dioxide equivalent by 2050 in the BAU case, respectively, more than 5.6 times of 2007 levels. Compared with the BAU case, the relative reductions achieved in the best case would be 15.8% and 27.6% for life cycle ED and GHG emissions, respectively. It is suggested for future policy implementation to support sustainable biofuel and high efficient electric-vehicles, and the deployment of coal-based fuels accompanied with low-carbon technology.

  19. Energy alternatives

    International Nuclear Information System (INIS)

    English. A special committe of the Canadian House of Commons was established on 23 May 1980 to investigate the use of alternative energy sources such as 'gasohol', liquified coal, solar energy, methanol, wind and tidal power, biomass, and propane. In its final report, the committee envisions an energy system for Canada based on hydrogen and electricity, using solar and geothermal energy for low-grade heat. The committe was not able to say which method of generating electricty would dominate in the next century, although it recommends that fossil fuels should not be used. The fission process is not specifically discussed, but the outlook for fusion was investigated, and continued governmental support of fusion research is recommended. The report proposes some improvements in governmental energy organizations and programs

  20. Response of Syngonium podophyllum L. ‘White Butterfly’ shoot cultures to alternative media additives and gelling agents, and flow cytometric analysis of regenerants

    Directory of Open Access Journals (Sweden)

    JAIME A. TEIXEIRA DA SILVA

    2015-05-01

    Full Text Available Abstract. Teixeira da Silva JA. 2015. Response of Syngonium podophyllum L. ‘White Butterfly’ shoot cultures to alternative media additives and gelling agents, and flow cytometric analysis of regenerants. Nusantara Bioscience 7: 26-32. Syngonium podophyllum L. (arrowhead vine is a popular leafy indoor pot plant whose tissue culture has been established, primarily through in vitro shoot culture, but several interesting aspects have not yet been explored. In this study, cv. ‘White Butterfly’ was used to investigate the response of shoot formation to alternative gelling agents and media additives. Gellan gum (Gelrite® at 2 g/L resulted in greater leaf production, plantlet fresh weight and higher chlorophyll content (SPAD value than all other gelling agents tested, including agar, Bacto agar, phytagel, oatmeal agar, potato dextrose agar, barley starch and corn starch, when on a basal Hyponex® (NPK = 6.5: 6: 19; 3 g/L medium. Several alternative liquid medium additives tested (low and full fat milk, Coca-Cola®, coffee, Japanese green, Oolong and Darjeeling teas negatively impacted plant growth, stunted roots and decreased chlorophyll content (SPAD value of leaves. Plant growth on medium with refined sucrose or table sugar responded similarly. Poor growth was observed when crude extract from a high rebaudioside-containing stevia (Stevia rebaudiana Bertoni line - an artificial sweetener - was used. Leaf tissue from the control did not show any endopolyploidy but low levels of endopolyploidy (8C were detected in some treatments.

  1. Alternative Green Solvents Project

    Science.gov (United States)

    Maloney, Phillip R.

    2012-01-01

    Necessary for safe and proper functioning of equipment. Mainly halogenated solvents. Tetrachloride, Trichloroethylene (TCE), CFC-113. No longer used due to regulatory/safety concerns. Precision Cleaning at KSC: Small % of total parts. Used for liquid oxygen (LOX) systems. Dual solvent process. Vertrel MCA (decafluoropentane (DFP) and trons-dichloroethylene) HFE-7100. DFP has long term environmental concerns. Project Goals: a) Identify potential replacements. b) 22 wet chemical processes. c) 3 alternative processes. d) Develop test procedures. e) Contamination and cleaning. f) Analysis. g) Use results to recommend alternative processes. Conclusions: a) No alternative matched Vertrel in this study. b) No clear second place solvent. c) Hydrocarbons- easy; Fluorinated greases- difficult. d) Fluorinated component may be needed in replacement solvent. e) Process may need to make up for shortcoming of the solvent. f) Plasma and SCC02 warrant further testing.

  2. Accident analysis for high-level waste management alternatives in the US Department of Energy Environmental Restoration and Waste Management Programmatic Environmental Impact Statement

    International Nuclear Information System (INIS)

    A comparative generic accident analysis was performed for the programmatic alternatives for high-level waste (HLW) management in the US Department of Energy Environmental Restoration and Waste Management Programmatic Environmental Impact Statement (EM PEIS). The key facilities and operations of the five major HLW management phases were considered: current storage, retrieval, pretreatment, treatment, and interim canister storage. A spectrum of accidents covering the risk-dominant accidents was analyzed. Preliminary results are presented for HLW management at the Hanford site. A comparison of these results with those previously advanced shows fair agreement

  3. On the Distance Dependence of the Price Elasticity of Telecommunications Demand; Meta-analysis, and Alternative Theoretical Backgrounds

    NARCIS (Netherlands)

    Ouwersloot, Hans; Rietveld, Piet

    1997-01-01

    The positive correlation between the absolute price elasticity of telecommunications demand and the distance of the calling relation is well known. In this paper we first present a meta-analysis of existing studies to buttress the distance dependence empirically. The analysis confirms the existence

  4. Accident analysis for transuranic waste management alternatives in the U.S. Department of Energy waste management program

    International Nuclear Information System (INIS)

    Preliminary accident analyses and radiological source term evaluations have been conducted for transuranic waste (TRUW) as part of the US Department of Energy (DOE) effort to manage storage, treatment, and disposal of radioactive wastes at its various sites. The approach to assessing radiological releases from facility accidents was developed in support of the Office of Environmental Management Programmatic Environmental Impact Statement (EM PEIS). The methodology developed in this work is in accordance with the latest DOE guidelines, which consider the spectrum of possible accident scenarios in the implementation of various actions evaluated in an EIS. The radiological releases from potential risk-dominant accidents in storage and treatment facilities considered in the EM PEIS TRUW alternatives are described in this paper. The results show that significant releases can be predicted for only the most severe and extremely improbable accidents sequences

  5. Nonlinear analysis of the change points between A and B phases during the Cyclic Alternating Pattern under normal sleep.

    Science.gov (United States)

    Chouvarda, I; Mendez, M O; Alba, A; Bianchi, A M; Grassi, A; Arce-Santana, E; Rosso, V; Terzano, M G; Parrino, L

    2012-01-01

    This study analyzes the nonlinear properties of the EEG at transition points of the sequences that build the Cyclic Alternating Pattern (CAP). CAP is a sleep phenomenon built up by consecutive sequences of activations and non-activations observed during the sleep time. The sleep condition can be evaluated from the patterns formed by these sequences. Eleven recordings from healthy and good sleepers were included in this study. We investigated the complexity properties of the signal at the onset and offset of the activations. The results show that EEG signals present significant differences (p<0.05) between activations and non-activations in the Sample Entropy and Tsallis Entropy indices. These indices could be useful in the development of automatic methods for detecting the onset and offset of the activations, leading to significant savings of the physician's time by simplifying the manual inspection task. PMID:23366075

  6. Alaska Regional Energy Resources Planning Project. Phase 2: coal, hydroelectric and energy alternatives. Volume I. Beluga Coal District Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rutledge, G.; Lane, D.; Edblom, G.

    1980-01-01

    This volume deals with the problems and procedures inherent in the development of the Beluga Coal District. Socio-economic implications of the development and management alternatives are discussed. A review of permits and approvals necessary for the initial development of Beluga Coal Field is presented. Major land tenure issues in the Beluga Coal District as well as existing transportation routes and proposed routes and sites are discussed. The various coal technologies which might be employed at Beluga are described. Transportation options and associated costs of transporting coal from the mine site area to a connecting point with a major, longer distance transportation made and of transporting coal both within and outside (exportation) the state are discussed. Some environmental issues involved in the development of the Beluga Coal Field are presented. (DMC)

  7. Alternative route for the MDW project for automotive fuels in the Dutch highway sector. A legal analysis

    International Nuclear Information System (INIS)

    In February 1998, the Dutch Government initiated an MDW project ('Marktwerking, Deregulering en Wetgevingskwaliteit', i.e. market functioning, deregulation and quality of legislation) to review ways in which competition within the motorway segment of the Dutch retail fuel market could be improved. The project reviewed the entry barriers and considered ways to stimulate competition, including preferential treatment of new entrants. The Dutch Major oil companies protested against the original plans of the Government and announced legal proceedings. The Government agreed to engage in negotiations with the oil industry in order to reach a compromise solution and avoid a legal battle. This resulted in an alternative route, which is analyzed in this article from a legal perspective

  8. Dynamic analysis of Free-Piston Stirling Engine/Linear Alternator-load system-experimentally validated

    Science.gov (United States)

    Kankam, M. David; Rauch, Jeffrey S.; Santiago, Walter

    1992-01-01

    This paper discusses the effects of variations in system parameters on the dynamic behavior of the Free-Piston Stirling Engine/Linear Alternator (FPSE/LA)-load system. The mathematical formulations incorporate both the mechanical and thermodynamic properties of the FPSE, as well as the electrical equations of the connected load. A state-space technique in the frequency domain is applied to the resulting system of equations to facilitate the evaluation of parametric impacts on the system dynamic stability. Also included is a discussion on the system transient stability as affected by sudden changes in some key operating conditions. Some representative results are correlated with experimental data to verify the model and analytic formulation accuracies. Guidelines are given for ranges of the system parameters which will ensure an overall stable operation.

  9. Analysis of operations and cyber security policies for a system of cooperating Flexible Alternating Current Transmission System (FACTS) devices.

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, Laurence R.; Tejani, Bankim; Margulies, Jonathan; Hills, Jason L.; Richardson, Bryan T.; Baca, Micheal J.; Weiland, Laura

    2005-12-01

    Flexible Alternating Current Transmission Systems (FACTS) devices are installed on electric power transmission lines to stabilize and regulate power flow. Power lines protected by FACTS devices can increase power flow and better respond to contingencies. The University of Missouri Rolla (UMR) is currently working on a multi-year project to examine the potential use of multiple FACTS devices distributed over a large power system region in a cooperative arrangement in which the FACTS devices work together to optimize and stabilize the regional power system. The report describes operational and security challenges that need to be addressed to employ FACTS devices in this way and recommends references, processes, technologies, and policies to address these challenges.

  10. Analysis of an alternative method for the study of bromeliad-associated fauna in plants with different foliar organization

    Directory of Open Access Journals (Sweden)

    Gerson A. Müller

    2010-12-01

    Full Text Available The efficiency of an alternative method of collection (by suction of water for the study of Culicidae and Chironomidae (Diptera, Scirtidae (Coleoptera and Coenagrionidae (Odonata in bromeliads with different foliar architecture in a restinga at Florianópolis, SC, Brazil, was studied. The alternative method was less efficient to collect Culicidae and Chironomidae (Wilcoxon test p 0.05 from Aechmea lindenii. This method was less efficient to collect insects of all groups from Vriesea friburgensis (Wilcoxon test p A eficiência do método alternativo de coleta (por sucção da água para o estudo de Culicidae e Chironomidae (Diptera, Scirtidae (Coleoptera e Coenagrionidae (Odonata em bromélias com diferentes estruturas foliares de restinga em Florianópolis, SC, Brasil, foi estudada. O método alternativo foi menos eficiente para coletar Culicidae e Chironomidae (teste de Wilcoxon p 0, 05 a partir de Aechmea lindenii. Esse foi menos eficiente para coletar insetos de todos os grupos a partir de Vriesea friburgensis (teste de Wilcoxon p < 0,05. O método alternativo se mostrou eficiente em estimar a diversidade desses insetos nas duas espécies de bromélias. A alta mobilidade das formas imaturas dos coleópteros e libélulas e a disponibilidade de apenas um tanque em Aechea lindenii, em contraste com as várias axilas e Vriesea friburgensis, facilitando a sucção destas formas imaturas provavelmente influenciaram os resultados. Os resultados indicam que o método de sucção não deve substituir o desmanche no estudo de Culicidae e Chironomidae; ele pode ser útil para a obtenção de formas imaturas de Scirtidae e Coenagrionidae em bromélias de um só tanque.

  11. Methodological approaches to analysis of agricultural countermeasures on radioactive contaminated areas: Estimation of effectiveness and comparison of different alternatives

    DEFF Research Database (Denmark)

    Yatsalo, B.I.; Hedemann Jensen, P.; Alexakhin, R.M.

    Methodological aspects of countermeasure analysis in the long-term period after a nuclear accident are discussed for agriculture countermeasures for illustrative purposes. The estimates of effectiveness fbr specific countermeasures as well as methods of justified action levels assessments and...

  12. On the Distance Dependence of the Price Elasticity of Telecommunications Demand; Meta-analysis, and Alternative Theoretical Backgrounds

    OpenAIRE

    Ouwersloot, Hans; Rietveld, Piet

    1997-01-01

    The positive correlation between the absolute price elasticity of telecommunications demand and the distance of the calling relation is well known. In this paper we first present a meta-analysis of existing studies to buttress the distance dependence empirically. The analysis confirms the existence of distance dependence, and gives insight into the size of the effect.Next we look for various explanations of the distance dependence. We analyse the roles of the functional form of demand functio...

  13. Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus): Molecular and functional characterization and immune responsive mRNA expression analysis.

    Science.gov (United States)

    Godahewa, G I; Perera, N C N; Bathige, S D N K; Nam, Bo-Hye; Noh, Jae Koo; Lee, Jehee

    2016-08-01

    The complement system serves conventional role in the innate defense against common invading pathogens. Complement factor D (CfD) is vital to alternative complement pathway activation in cleaving complement factor B. This catalytic reaction forms the alternative C3 convertase that is crucial for complement-mediated pathogenesis. In this study, rock bream (Oplegnathus fasciatus) CfD (OfCfD) was characterized and OfCfD mRNA expression was investigated. OfCfD encodes 277 amino acids (aa) for a 30-kDa polypeptide. A domain analysis of the deduced OfCfD aa sequence showed a single serine protease trypsin superfamily domain, a serine active region, three active sites, and three substrate-binding sites. Pairwise sequence comparisons indicated that OfCfD has the highest identity (84.5%) with Oreochromis niloticus CfD. The phylogenetic tree revealed a common ancestral origin of CfD members, with fish CfD distinct from other vertebrate orthologs. The structural arrangement of the OfCfD gene (2451 bp) contained five exons interrupted by four introns. A spatial transcriptional analysis indicated that OfCfD transcripts constitutively expressed in all of the examined rock bream tissues, and that they were highest in the spleen and liver. In addition, OfCfD transcripts were immunologically upregulated by lipopolysaccharide (LPS) (12 h p.i.), Streptococcus iniae (12 h p.i.), rock bream iridovirus (RBIV) (6-12 h p.i.), and poly I:C (6 h p.i.) in spleen tissue. OfCfD is a trypsin protease and its recombinant protein showed strong protease activity similar to that of trypsin, indicating its catalytic function in the alternative pathway. Together, our findings suggest that OfCfD might be involved in immune responses in rock bream. PMID:27311435

  14. Economic analysis of the use of coronary calcium scoring as an alternative to stress ECG in the non-invasive diagnosis of coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Raman, Vivek [Brighton and Sussex University Hospitals, Brighton (United Kingdom); Royal Sussex County Hospital, Brighton (United Kingdom); McWilliams, Eric T.M. [Conquest Hospital, Hastings (United Kingdom); Holmberg, Stephen R.M.; Miles, Ken [Brighton and Sussex University Hospitals, Brighton (United Kingdom)

    2012-03-15

    To conduct an economic analysis (EA) of coronary calcium scoring (CCS) using a 0 score, as alternative to stress electrocardiography (sECG) in diagnosing coronary artery disease (CAD). A decision tree was constructed to compare four strategies for investigation of suspected CAD previously assessed in the formulation of clinical guidelines for the United Kingdom (UK) to two new strategies incorporating CCS. Sensitivity (96%; 95% CI 95.4-96.4%) and specificity (40%; 95% CI 38.7-41.4%) values for CCS were derived from a meta-analysis of 10,760 patients. Other input variables were obtained from a previous EA and average prices for hospital procedures in the UK. A threshold of pound 30,000/Quality-adjusted Life Year (QALY) was considered cost-effective. Using net monetary benefit calculations, CCS-based strategies were found to be cost-effective compared to sECG equivalents at all assessed prevalence of CAD. Using CCS prior to myocardial perfusion scintigraphy (MPS) and catheter angiography (CA) was found to be cost-effective at pre-test probabilities (PTP) below 30%. Adoption of CCS as an alternative to sECG in investigating suspected stable angina in low PTP population (<30%) would be cost-effective. In patients with PTP of CAD >30%, proceeding to MPS or CA would be more cost-effective than performing either CCS or sECG. (orig.)

  15. Data collection and analysis in support of the US Department of Energy Environmental Restoration and Waste Management Programmatic Environmental Impact Statement waste management alternatives

    International Nuclear Information System (INIS)

    This paper is a report on work in progress in support of the US Department of Energy Environmental Restoration and Waste Management (EM) Programmatic Environmental Impact Statement (PEIS). Argonne National Laboratory (ANL) has been providing technical support in the areas of waste characterization; waste treatment, storage, and disposal (TSD) facility descriptions (developed jointly with EG ampersand G, Idaho); analysis of potential accidents at TSD facilities; and waste transportation risk assessment. Support efforts encompass the following six waste types: high-level waste; transuranic waste; low-level waste; greater-than Class-C low-level waste; low-level mixed waste; and hazardous waste. Treatment, storage, and disposal facility descriptions cover the following parameters: resource requirements, cost, staffing, capacity, by-products, and effluents. The variations in these parameters effected by the proposed alternatives are estimated. Selection of proposed initiating events, characterization of source terms, and descriptions of scenarios are covered in the accident analysis portion of the ANL work. The transportation risk assessment portion includes both off-site and on-site transportation of both radioactive and hazardous wastes for all waste management alternatives under consideration in the EM PEIS

  16. Economic analysis of the use of coronary calcium scoring as an alternative to stress ECG in the non-invasive diagnosis of coronary artery disease

    International Nuclear Information System (INIS)

    To conduct an economic analysis (EA) of coronary calcium scoring (CCS) using a 0 score, as alternative to stress electrocardiography (sECG) in diagnosing coronary artery disease (CAD). A decision tree was constructed to compare four strategies for investigation of suspected CAD previously assessed in the formulation of clinical guidelines for the United Kingdom (UK) to two new strategies incorporating CCS. Sensitivity (96%; 95% CI 95.4-96.4%) and specificity (40%; 95% CI 38.7-41.4%) values for CCS were derived from a meta-analysis of 10,760 patients. Other input variables were obtained from a previous EA and average prices for hospital procedures in the UK. A threshold of pound 30,000/Quality-adjusted Life Year (QALY) was considered cost-effective. Using net monetary benefit calculations, CCS-based strategies were found to be cost-effective compared to sECG equivalents at all assessed prevalence of CAD. Using CCS prior to myocardial perfusion scintigraphy (MPS) and catheter angiography (CA) was found to be cost-effective at pre-test probabilities (PTP) below 30%. Adoption of CCS as an alternative to sECG in investigating suspected stable angina in low PTP population (30%, proceeding to MPS or CA would be more cost-effective than performing either CCS or sECG. (orig.)

  17. Analysis of time-variant quadratic phase couplings in the tracé alternant EEG by recursive estimation of 3rd-order time-frequency distributions.

    Science.gov (United States)

    Helbig, Marko; Schwab, Karin; Leistritz, Lutz; Eiselt, Michael; Witte, Herbert

    2006-10-15

    The quantification of transient quadratic phase couplings (QPC) by means of time-variant bispectral analysis is a useful approach to explain several interrelations between signal components. A generalized recursive estimation approach for 3rd-order time-frequency distributions (3rd-order TFD) is introduced. Based on 3rd-order TFD, time-variant estimations of biamplitude (BA), bicoherence (BC) and phase bicoherence (PBC) can be derived. Different smoothing windows and local moment functions for an optimization of the estimation properties are investigated and compared. The methods are applied to signal simulations and EEG signals, and it can be shown that the new time-variant bispectral analysis results in a reliable quantification of QPC in the tracé alternant EEG of healthy neonates. PMID:16737739

  18. Simultaneous quantitative analysis of olmesartan, amlodipine and hydrochlorothiazide in their combined dosage form utilizing classical and alternating least squares based chemometric methods

    Directory of Open Access Journals (Sweden)

    Darwish Hany W.

    2016-03-01

    Full Text Available Simultaneous spectrophotometric analysis of a multi-component dosage form of olmesartan, amlodipine and hydrochlorothiazide used for the treatment of hypertension has been carried out using various chemometric methods. Multivariate calibration methods include classical least squares (CLS executed by net analyte processing (NAP-CLS, orthogonal signal correction (OSC-CLS and direct orthogonal signal correction (DOSC-CLS in addition to multivariate curve resolution-alternating least squares (MCR-ALS. Results demonstrated the efficiency of the proposed methods as quantitative tools of analysis as well as their qualitative capability. The three analytes were determined precisely using the aforementioned methods in an external data set and in a dosage form after optimization of experimental conditions. Finally, the efficiency of the models was validated via comparison with the partial least squares (PLS method in terms of accuracy and precision.

  19. Evaluation of Electronic Commerce (E-Commerce with SWOT Analysis as an Alternative Network Marketing at Agricultural Marketing

    Directory of Open Access Journals (Sweden)

    Nuray Kızılaslan

    2015-07-01

    Full Text Available Compulsory competition occurring in the world trade has led the enterprises to different marketing system. Marketing problems seems to be a problem in Turkey rather than agricultural production problems. In this aspect, marketing alternatives are sought. E-commerce is a system with more opportunities in agricultural marketing. Increasing the applicability of this system in Turkey will eliminate many problems associated with marketing in agriculture. With an active use of E-commerce in agricultural marketing, it provides convenience at marketing products of agro-related industries agencies and producers and all country will have a potential market position. In this study, possibilities offered by e-commerce to the agricultural sector, opportunities, threats, deficiencies and contributions to agricultural sector have been addressed. Without the limitations of place and time via the internet and computers, establishing national and international supply and demand balance of e-commerce seems to play important roles in maintaining an active and alive marketing. Furthermore, it is an important tool in reducing agricultural marketing problems.

  20. Effects of alternate fuels. Report No. 6. Analysis of low-alumina castable refractory degraded by residual oil combustion products

    Energy Technology Data Exchange (ETDEWEB)

    Wei, G. C.; Tennery, V. J.

    1978-07-01

    This is the sixth of a series of reports on analyses of several types of refractories used in industrial furnaces with fuels considered alternate to natural gas. Analyses were performed on a low-alumina castable used for only two months in the roof of a residual-oil-fired boiler. The maximum hot-face temperature during operation was about 1530/sup 0/K. The original microstructure of the castable, which consisted of mullite aggregate bonded with iron-containing gehlenite (2 CaO . Al/sub 2/O/sub 3/ . SiO/sub 2/), quartz and cristobalite, was totally altered during service in regions close to the hot face. At room temperature the altered microstructure consisted of corundum and gehlenite in a new oxide glass phase containing the elements Na, K, Ca, Fe, Ti, Al, Ni, and Si. The reactions of the fuel oil impurities Na, Fe, and Ni with mullite, quartz, and cristobalite in the original castable refractory caused the rapid degradation at the hot face during service in the boiler. Increasing the Al/sub 2/O/sub 3/ content of the castable by replacing mullite aggregate with alumina aggregate and using gehlenite with less iron impurity as the bonding material should improve the performance of this castable refractory or retard reactions of the castable with fuel oil combustion products including Na, Fe, and Ni.

  1. Analysis of factors that affect the potential of star fruit (Averhoa Bilimbi) and cactus (Gymnocalycium Hossei) extracts as alternative battery

    Science.gov (United States)

    Rahmawati, Sitti; Agnesstacia

    2014-03-01

    This research analyzes the factors that affect the work of the battery from the star fruit extract and the cactus extract. The value voltage and current generated are measure the work of the battery. Voltage measurement based on the electrode distance function, and electrode surface area. Voltage as a surface area electrode function and electrode distance function determined the current density and the voltage generated. From the experimental results obtained that the battery voltage is large enough, it is about 1.8 V for the extract of star fruit, and 1.7 V for the extract of cactus, which means that the juice extract from star fruit and the juice extract of cactus can become an alternative as battery replacement. The measurements with different electrode surface area on the star fruit and cactus extract which has the depth of the electrode 0.5 cm to 4 cm causes a decrease in the electric current generated from 12.5 mA to 1.0 mA, but obtained the same voltage.

  2. Optimization and analysis of alternative trapezoidal labyrinth weir; Otimizacao e analise de alternativas de vertedor do tipo Labirinto trapezoidal

    Energy Technology Data Exchange (ETDEWEB)

    Roselli, Rafael Gustavo [Universidade de Sao Paulo (USP), SP (Brazil)], email: rafaelroselli@yahoo.com.br

    2011-04-15

    This paper proposes solutions based on an analysis developed in spillway structures, involving analysis of the criteria for the design of labyrinth weirs. For this purpose, it is necessary to study and compare results to be developed in each project with respect to hydraulic factors, hydrological, geological, topographical and involving risks of losses caused by failures in hydraulic structures. The proposition of optimizing the arrangement of the spillway structure type labyrinth is designed to improve the safety of the construction and of the operation, focusing on the development of the ideal spillway for the case study. (author)

  3. Alternative Splice in Alternative Lice.

    Science.gov (United States)

    Tovar-Corona, Jaime M; Castillo-Morales, Atahualpa; Chen, Lu; Olds, Brett P; Clark, John M; Reynolds, Stuart E; Pittendrigh, Barry R; Feil, Edward J; Urrutia, Araxi O

    2015-10-01

    Genomic and transcriptomics analyses have revealed human head and body lice to be almost genetically identical; although con-specific, they nevertheless occupy distinct ecological niches and have differing feeding patterns. Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases; epidemictyphus, trench fever, and relapsing fever. In order to gain insights into the molecular bases for these differences, we analyzed alternative splicing (AS) using next-generation sequencing data for one strain of head lice and one strain of body lice. We identified a total of 3,598 AS events which were head or body lice specific. Exon skipping AS events were overrepresented among both head and body lice, whereas intron retention events were underrepresented in both. However, both the enrichment of exon skipping and the underrepresentation of intron retention are significantly stronger in body lice compared with head lice. Genes containing body louse-specific AS events were found to be significantly enriched for functions associated with development of the nervous system, salivary gland, trachea, and ovarian follicle cells, as well as regulation of transcription. In contrast, no functional categories were overrepresented among genes with head louse-specific AS events. Together, our results constitute the first evidence for transcript pool differences in head and body lice, providing insights into molecular adaptations that enabled human lice to adapt to clothing, and representing a powerful illustration of the pivotal role AS can play in functional adaptation. PMID:26169943

  4. A Legitimate Case of Component Analysis of Ipsative Measures, and Partialling the Mean as an Alternative to Ipsatization

    NARCIS (Netherlands)

    Ten Berge, J.M.F.

    1999-01-01

    Ipsatizing variables prior to component analysis, by subtracting the mean score of each individual from all scores of that individual, has met with serious criticisms, both strategic and technical. On the other hand, the procedure is still popular in the study of personality, as a means of removing

  5. 78 FR 32558 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe...

    Science.gov (United States)

    2013-05-31

    ... Water Act; Analysis and Sampling Procedures. 74 FR 38348. August 3, 2009. USEPA. 2013. EPA Method 524.4.... Fluoride. B. Preliminary Distillation Step. C. Ion-Selective Electrode Method. D. SPADNS Method. E.... ASTM D516-02. Standard Test Method for Sulfate Ion in Water. ASTM International, 100 Barr Harbor...

  6. The cost-effectiveness of neonatal screening for Cystic Fibrosis: an analysis of alternative scenarios using a decision model

    Directory of Open Access Journals (Sweden)

    Tu Karen

    2005-08-01

    Full Text Available Abstract Background The use of neonatal screening for cystic fibrosis is widely debated in the United Kingdom and elsewhere, but the evidence available to inform policy is limited. This paper explores the cost-effectiveness of adding screening for cystic fibrosis to an existing routine neonatal screening programme for congenital hypothyroidism and phenylketonuria, under alternative scenarios and assumptions. Methods The study is based on a decision model comparing screening to no screening in terms of a number of outcome measures, including diagnosis of cystic fibrosis, life-time treatment costs, life years and QALYs gained. The setting is a hypothetical UK health region without an existing neonatal screening programme for cystic fibrosis. Results Under initial assumptions, neonatal screening (using an immunoreactive trypsin/DNA two stage screening protocol costs £5,387 per infant diagnosed, or £1.83 per infant screened (1998 costs. Neonatal screening for cystic fibrosis produces an incremental cost-effectiveness of £6,864 per QALY gained, in our base case scenario (an assumed benefit of a 6 month delay in the emergence of symptoms. A difference of 11 months or more in the emergence of symptoms (and mean survival means neonatal screening is both less costly and produces better outcomes than no screening. Conclusion Neonatal screening is expensive as a method of diagnosis. Neonatal screening may be a cost-effective intervention if the hypothesised delays in the onset of symptoms are confirmed. Implementing both antenatal and neonatal screening would undermine potential economic benefits, since a reduction in the birth incidence of cystic fibrosis would reduce the cost-effectiveness of neonatal screening.

  7. Life cycle analysis and choice of natural gas-based automotive alternative fuels in Chongqing Municipality,China

    Institute of Scientific and Technical Information of China (English)

    WU Rui; LI Guangyi; ZHANG Zongyi; REN Yulong; HAN Weijian

    2007-01-01

    Road transport produces significant amounts of emissions by using crude oil as the primary energy source.A reduction of emissions can be achieved by implementing alternative fuel chains.The objective of this study is to carry out an economic,environmental and energy (EEE) life cycle study on natural gas-based automotive fuels with conventional gasoline in an abundant region of China.A set of indices of four fuels/vehicle systems on the basis of life cycle are assessed in terms of impact of EEE,in which natural gas produces compressed natural gas (CNG),methanol,dimethylether (DME) and Fischer Tropsch diesel (FTD).The study included fuel production,vehicle production,vehicle operation,infrastructure and vehicle end of life as a system for each fuel/vehicle system.A generic gasoline fueled car is used as a baseline.Data have been reviewed and modified based on the best knowledge available to Chongqing local sources.Results indicated that when we could not change electric and hydrogen fuel cell vehicles into commercial vehicles on a large scale,direct use of CNG in a dedicated or bi-fuel vehicle is an economical choice for the region which is most energy efficient and more environmental friendly.The study can be used to support decisions on how natural gas resources can best be utilized as a fuel/energy resource for automobiles,and what issues need to be resolved in Chongqing.The models and approaches for this study can be applied to other regions of China as long as all the assumptions are well defined and modified to find a substitute automotive energy source and establish an energy policy in a specific region.

  8. Looking for an Alternative.

    Science.gov (United States)

    Kennedy, Jack

    1999-01-01

    Argues that high school newspapers might do well to create stronger ties with alternative weeklies. Discusses issues of niche marketing, alternative content, and alternative presentation. Notes that high school papers could learn a lot from alternative newspapers. (SR)

  9. Synchrotron radiation induced x-ray micro analysis: A realistic alternative for electron- and ion beam microscopy?

    International Nuclear Information System (INIS)

    Synchrotron Radiation induced X-ray micro Fluorescence analysis (μ-SRXRF) is compared with more conventional microanalytical techniques such as Secondary Ion Microscopy (SIMS) and Electron Probe X-ray Microanalysis (EPXMA) for two typical microanalytical applications. SRXRF and EPXMA are employed for the analysis of individual particles, showing the complementary character of both techniques. By means of element mapping of trace constituents in a heterogeneous feldspar, the strong and weak points of SRXRF in comparison to EPXMA and SIMS are illustrated. The most striking difference between SRXRF and the other two microanalytical methods is the ability of SRXRF to probe deep into the investigated Material, whereas SIMS and EPXMA only investigate the upper surface of the material. The possibilities of SRXRF at third generation synchrotron rings is also briefly discussed

  10. Thermodynamic Analysis of Actual Vapour Compression System with R12 and Its Eco-Friendly Alternatives Refrigerants

    OpenAIRE

    Vijay Singh Bisht; A.K.Pratihar

    2014-01-01

    This paper presents a theoretical performance study of a vapour compression refrigeration system with refrigerants R-12, R134a and R1234yf. A computational model based on energy first law analysis is presented for the investigation of the effects of evaporating temperatures, degree of subcooling, dead state temperatures and effectiveness of the liquid vapour heat exchanger on the relative capacity change index, coefficient of performance of the vapour compression refrigeration cycle. RCI (rel...

  11. Impact Assessment and Multicriteria Decision Analysis of Alternative Managed Aquifer Recharge Strategies Based on Treated Wastewater in Northern Gaza

    OpenAIRE

    Mohammad Azizur Rahman; Bernd Rusteberg; Mohammad Salah Uddin; Muath Abu Saada; Ayman Rabi; Martin Sauter

    2014-01-01

    For better planning of a managed aquifer recharge (MAR) project, the most promising strategies should analyze the environmental impact, socio-economic efficiency, and their contribution to the existing or future water resource conditions in the region. The challenge of such studies is to combine and quantify a wide range of criteria from the environment and society. This necessity leads to an integrated concept and analysis. This paper outlines an integrated approach considering environmental...

  12. lociNGS: A Lightweight Alternative for Assessing Suitability of Next-Generation Loci for Evolutionary Analysis

    OpenAIRE

    Hird, Sarah M.

    2012-01-01

    Genomic enrichment methods and next-generation sequencing produce uneven coverage for the portions of the genome (the loci) they target; this information is essential for ascertaining the suitability of each locus for further analysis. lociNGS is a user-friendly accessory program that takes multi-FASTA formatted loci, next-generation sequence alignments and demographic data as input and collates, displays and outputs information about the data. Summary information includes the parameters cove...

  13. Stochastic dominance analysis of on-farm-trial data: The riskiness of alternative phosphate sources in Burkina Faso

    OpenAIRE

    Hien, Victor; Kabore, Daniel; Youl, Sansan; Lowenberg-DeBoer, J.

    1997-01-01

    Stochastic dominance was used to determine the risk characteristics of phosphate fertilization of millet, sorghum and maize with commercial NPK fertilizer, rock phosphate and partially acidulated rock phosphate in Burkina Faso. On-farm-trial data from 1989, 1990 and 1991 in three rainfall zones was used. The analysis shows that among the four treatments tested, commercial NPK fertilizer has the most desirable risk characteristics. It is acceptable to risk averse decision makers for all three ...

  14. Continuous Wavelet Transform, a powerful alternative to Derivative Spectrophotometry in analysis of binary and ternary mixtures: A comparative study.

    Science.gov (United States)

    Elzanfaly, Eman S; Hassan, Said A; Salem, Maissa Y; El-Zeany, Badr A

    2015-12-01

    A comparative study was established between two signal processing techniques showing the theoretical algorithm for each method and making a comparison between them to indicate the advantages and limitations. The methods under study are Numerical Differentiation (ND) and Continuous Wavelet Transform (CWT). These methods were studied as spectrophotometric resolution tools for simultaneous analysis of binary and ternary mixtures. To present the comparison, the two methods were applied for the resolution of Bisoprolol (BIS) and Hydrochlorothiazide (HCT) in their binary mixture and for the analysis of Amlodipine (AML), Aliskiren (ALI) and Hydrochlorothiazide (HCT) as an example for ternary mixtures. By comparing the results in laboratory prepared mixtures, it was proven that CWT technique is more efficient and advantageous in analysis of mixtures with severe overlapped spectra than ND. The CWT was applied for quantitative determination of the drugs in their pharmaceutical formulations and validated according to the ICH guidelines where accuracy, precision, repeatability and robustness were found to be within the acceptable limit. PMID:26186613

  15. Exon Array Analysis using re-defined probe sets results in reliable identification of alternatively spliced genes in non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Gröne Jörn

    2010-11-01

    Full Text Available Abstract Background Treatment of non-small cell lung cancer with novel targeted therapies is a major unmet clinical need. Alternative splicing is a mechanism which generates diverse protein products and is of functional relevance in cancer. Results In this study, a genome-wide analysis of the alteration of splicing patterns between lung cancer and normal lung tissue was performed. We generated an exon array data set derived from matched pairs of lung cancer and normal lung tissue including both the adenocarcinoma and the squamous cell carcinoma subtypes. An enhanced workflow was developed to reliably detect differential splicing in an exon array data set. In total, 330 genes were found to be differentially spliced in non-small cell lung cancer compared to normal lung tissue. Microarray findings were validated with independent laboratory methods for CLSTN1, FN1, KIAA1217, MYO18A, NCOR2, NUMB, SLK, SYNE2, TPM1, (in total, 10 events and ADD3, which was analysed in depth. We achieved a high validation rate of 69%. Evidence was found that the activity of FOX2, the splicing factor shown to cause cancer-specific splicing patterns in breast and ovarian cancer, is not altered at the transcript level in several cancer types including lung cancer. Conclusions This study demonstrates how alternatively spliced genes can reliably be identified in a cancer data set. Our findings underline that key processes of cancer progression in NSCLC are affected by alternative splicing, which can be exploited in the search for novel targeted therapies.

  16. Molecular characterization, alternative splicing and expression analysis of ACSF2 and its correlation with egg-laying performance in geese.

    Science.gov (United States)

    Yu, S; Wei, W; Xia, M; Jiang, Z; He, D; Li, Z; Han, H; Chu, W; Liu, H; Chen, J

    2016-08-01

    ACSF2 (encoded by acyl-CoA synthetase family member 2) belongs to the acyl-CoA synthetase (ACS) family, activating fatty acids by forming a thioester bond with CoA. In our previous study, a SNP residing in the intron of ACSF2 was identified to be linked to goose egg-laying performance. But the structure of goose ACSF2 as well as its role in reproduction remains unknown. In this study, we cloned and characterized ACSF2 in Yangzhou geese. A total of four alternative splice variants, designated as ACSF2-1, ACSF2-2, ACSF2-3 and ACSF2-4 respectively, were identified in the ovary. The coding regions of the four variants are 1770, 1692, 1599 and 1917 bp in length, respectively encoding 589, 563, 532 and 638 amino acids with conserved AMP-binding sites. All ACSF2 variants were widely expressed in 11 tested tissues in geese, except that the ACSF2-2 transcript was not detected in hypothalamus, pituitary gland and granulosa cells. Subcellular localization revealed that ACSF2 is a mitochondrial matrix protein. ACSF2 mRNA level was compared between high egg production (HEP; n = 8) and low egg production (LEP; n = 10) groups and showed a lower (P < 0.05) mRNA level in the HEP group. Further experiments indicated that overexpressing ACSF2 resulted in a significant increase of caspase-3 mRNA levels and that ACSF2 knockdown triggered a decrease in the caspase-3 mRNA level in granulosa cells. Similarly, the lower caspase-3 mRNA levels were identified in ovaries of the HEP group with lower ACSF2 mRNA levels. The research showed that the ACSF2 mRNA levels had a positive correlation with caspase-3 mRNA levels in vivo (R = 0.86, P < 0.01). Our results suggest that lower ACSF2 expression promotes the laying performance of goose possibly by inhibiting granulosa cell apoptosis and facilitating follicular development. PMID:27062512

  17. Cost-effectiveness analysis of paclitaxel + carboplatin vs. alternative combinations in the treatment of non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Mario Eandi

    2006-06-01

    Full Text Available Non-small cell lung cancer (NSCLC is the most common type of lung cancer and its medical and economical burden represents a serious matter in Europe and Usa, due to its high mortality rates and drug costs. Lung cancer is responsible for about 30% of cancer death in men and women; in Europe only about 8 per cent of people with lung cancer survive for 5 years. At present combination chemotherapy based on cisplatin or carboplatin associated with paclitaxel, vinorelbine or gemcitabine is the state of the art for the treatment in patients with stage IIIb or IV NSCLC. Aim of this study was to compare the cost-effectiveness of paclitaxel/carboplatin (PCb, gemcitabine/cisplatin (GC and vinorelbine/cisplatin (VC in the perspective of the Italian National Health Service. Therefore we perfomed a semi-Markov decision model mainly based on clinical results from the Italian Lung Cancer Project. The model included differential direct medical costs registered for two years from starting chemotherapy, using tariffs valid for 2005. Benefits was measured by years of life saved (YOLs. The model also allowed to estimate only costs accrued over the period of time, performing a cost-minimisation analysis. According to cost-effectiveness analysis, VC is dominated because it’s more costly and less effective than GC. On the contrary, combination chemotherapy with GC is more inexpensive but less effective than paclitaxel/carboplatin (PCb: in this case we compared the incremental cost-effectiveness ratio (ICER with a maximum acceptable willingness-to-pay (WTP value. In the base scenario the ICER of PCb over GC treatment is 52,326 euro/ YOLs, which is definitely lower than the maximum acceptable WTP value. Sensitivity analyses confirmed the robustness of the results from cost-effectiveness analysis in the base scenario.

  18. Transport Catastrophe Analysis as an Alternative to a Monofractal Description: Theory and Application to Financial Crisis Time Series

    Directory of Open Access Journals (Sweden)

    Sergey A. Kamenshchikov

    2014-01-01

    Full Text Available The goal of this investigation was to overcome limitations of a persistency analysis, introduced by Benoit Mandelbrot for monofractal Brownian processes: nondifferentiability, Brownian nature of process, and a linear memory measure. We have extended a sense of a Hurst factor by consideration of a phase diffusion power law. It was shown that precatastrophic stabilization as an indicator of bifurcation leads to a new minimum of momentary phase diffusion, while bifurcation causes an increase of the momentary transport. An efficiency of a diffusive analysis has been experimentally compared to the Reynolds stability model application. An extended Reynolds parameter has been introduced as an indicator of phase transition. A combination of diffusive and Reynolds analyses has been applied for a description of a time series of Dow Jones Industrial weekly prices for the world financial crisis of 2007–2009. Diffusive and Reynolds parameters showed extreme values in October 2008 when a mortgage crisis was fixed. A combined R/D description allowed distinguishing of market evolution short-memory and long-memory shifts. It was stated that a systematic large scale failure of a financial system has begun in October 2008 and started fading in February 2009.

  19. Some observations from radiometric ‘8 bit’ data of sediment thin sections based on alternative petrographic image analysis method

    Indian Academy of Sciences (India)

    Sudip Dey; Suvendu Ghosh; Chandrani Debbarma; Prasamita Sarkar; Mhu Aris Marfai; Sabyasachi Maiti

    2009-04-01

    This paper deals with the experiment of sediment microstructure analysis especially microfabric mapping by digital imaging.For that purpose the greyscale images (Red band from RGB combination)of the thin sections have been prepared from the selected 12 samples.The basis of this mapping is the reflectance capacity of different sediments which is influenced by the physical parameters like grain size and colour.The reflectances of different sediments are represented in digital format by different DN values from 0 –255 within the radiometric ranges of ‘8 bit ’data. Density slicing has been chosen as the method of microstructure mapping in this research.This study shows that lower DN values normally present dark coloured coarser sand and clay while higher DN values present light coloured finer sediment samples.In the selected samples for this study the maximum DN value has been found from micaceous materials.Another remarkable thing observed from the microfabric mapping is that the presence of coarser sediments forms complex microfabric pattern than the finer sediments in the study area.Though this method have some demerits,still its simple technique can be very useful for accurate microstructure analysis.

  20. Numerical analysis of the source-sink alternation of composite global warming potential of the paddy ecosystem in the Yangtze Delta

    Institute of Scientific and Technical Information of China (English)

    LIU; Jiandong(刘建栋); ZHOU; Xiuji(周秀骥); YU; Qiang(于强)

    2003-01-01

    By coupling the biogeochemical model with plant ecological model, a model was established to reveal the principle of the composite global warming potential transformation in the paddy ecosystem. Validation of the model with the observed data indicated that the model can simulate both the crop growth processes and emissions of CH4 and N2O accurately. Some numerical analyses were made to identify the impacts of different fertilizer application on assimilation of CO2 and emissions of CH4 and N2O, and the transformation principle of the composite global warming potential. Based on the results of the numerical analysis, the source-sink alternation of composite global warming potential in the paddy ecosystem was discovered, and some new conceptions of fertilizer index such as maximum-sink fertilizer, zero-emission fertilizer are put forward in this paper. The fertilizer scheme for Yangtze Delta was proposed to provide the important scientific basis for a sustainable agriculture in this region.

  1. An Alternate Approach to Optimal L 2 -Error Analysis of Semidiscrete Galerkin Methods for Linear Parabolic Problems with Nonsmooth Initial Data

    KAUST Repository

    Goswami, Deepjyoti

    2011-09-01

    In this article, we propose and analyze an alternate proof of a priori error estimates for semidiscrete Galerkin approximations to a general second order linear parabolic initial and boundary value problem with rough initial data. Our analysis is based on energy arguments without using parabolic duality. Further, it follows the spirit of the proof technique used for deriving optimal error estimates for finite element approximations to parabolic problems with smooth initial data and hence, it unifies both theories, that is, one for smooth initial data and other for nonsmooth data. Moreover, the proposed technique is also extended to a semidiscrete mixed method for linear parabolic problems. In both cases, optimal L2-error estimates are derived, when the initial data is in L2. A superconvergence phenomenon is also observed, which is then used to prove L∞-estimates for linear parabolic problems defined on two-dimensional spatial domain again with rough initial data. Copyright © Taylor & Francis Group, LLC.

  2. Impact Assessment and Multicriteria Decision Analysis of Alternative Managed Aquifer Recharge Strategies Based on Treated Wastewater in Northern Gaza

    Directory of Open Access Journals (Sweden)

    Mohammad Azizur Rahman

    2014-12-01

    Full Text Available For better planning of a managed aquifer recharge (MAR project, the most promising strategies should analyze the environmental impact, socio-economic efficiency, and their contribution to the existing or future water resource conditions in the region. The challenge of such studies is to combine and quantify a wide range of criteria from the environment and society. This necessity leads to an integrated concept and analysis. This paper outlines an integrated approach considering environmental, health, social and economic aspects to support in the decision-making process to implement a managed aquifer recharge project as a potential response to water resource problems. In order to demonstrate the approach in detail, this paper analysed several water resources management strategies based on MAR implementation, by using treated wastewater in the Northern Gaza Strip and the potential impacts of the strategies on groundwater resources, agriculture, environment, health, economy and society. Based on the Palestinian water policy (Year 2005–2025 on wastewater reuse, three MAR strategies were developed in close cooperation with the local decision makers. The strategies were compared with a base line strategy referred to as the so-called “Do Nothing Approach”. The results of the study show that MAR project implementation with treated wastewater at a maximum rate, considered together with sustainable development of groundwater, is the best and most robust strategy amongst those analyzed. The analysis shows the defined MAR strategies contribute to water resources development and environmental protection or improvement including an existing eutrophic lake. The integrated approach used in this paper may be applicable not only to MAR project implementation but also to other water resources and environmental development projects.

  3. [Alternatives to animal testing].

    Science.gov (United States)

    Fabre, Isabelle

    2009-11-01

    The use of alternative methods to animal testing are an integral part of the 3Rs concept (refine, reduce, replace) defined by Russel & Burch in 1959. These approaches include in silico methods (databases and computer models), in vitro physicochemical analysis, biological methods using bacteria or isolated cells, reconstructed enzyme systems, and reconstructed tissues. Emerging "omic" methods used in integrated approaches further help to reduce animal use, while stem cells offer promising approaches to toxicologic and pathophysiologic studies, along with organotypic cultures and bio-artificial organs. Only a few alternative methods can so far be used in stand-alone tests as substitutes for animal testing. The best way to use these methods is to integrate them in tiered testing strategies (ITS), in which animals are only used as a last resort. PMID:20669543

  4. FEM numerical analysis of excimer laser induced modification in alternating multi-layers of amorphous and nano-crystalline silicon films

    Energy Technology Data Exchange (ETDEWEB)

    Conde, J.C., E-mail: jconde@uvigo.es [Dpto. Fisica Aplicada, Universidade de Vigo, Rua Maxwell s/n, Campus Universitario Lagoas Marcosende, Vigo (Spain); Martin, E. [Dpto. Mecanica, Maquinas, Motores Termicos y Fluidos, Universidade de Vigo, Rua Maxwell s/n, Campus Universitario Lagoas Marcosende, Vigo (Spain); Stefanov, S. [Dpto. Fisica Aplicada, Universidade de Vigo, Rua Maxwell s/n, Campus Universitario Lagoas Marcosende, Vigo (Spain); Alpuim, P. [Departamento de Fisica, Universidade do Minho, 4800-058 Guimaraes (Portugal); Chiussi, S. [Dpto. Fisica Aplicada, Universidade de Vigo, Rua Maxwell s/n, Campus Universitario Lagoas Marcosende, Vigo (Spain)

    2012-09-15

    Highlights: Black-Right-Pointing-Pointer nc-Si:H is a material with growing importance for a large-area of nano-electronic, photovoltaic or biomedical devices. Black-Right-Pointing-Pointer UV-ELA technique causes a rapid heating that provokes the H{sub 2} desorption from the Si surface and bulk material. Black-Right-Pointing-Pointer Next, diffusion of P doped nc-Si films and eventually, for high energy densities would be possible to reach the melting point. Black-Right-Pointing-Pointer These multilayer structures consisting of thin alternating a-Si:H(10 nm) and n-doped nc-Si:H(60 nm) films deposited on SiO{sub 2}. Black-Right-Pointing-Pointer To optimize parameters involved in this processing, FEM numerical analysis of multilayer structures have been performed. Black-Right-Pointing-Pointer The numerical results are compared with exhaustive characterization of the experimental results. - Abstract: UV excimer laser annealing (UV-ELA) is an alternative annealing process that, during the last few years, has gained enormous importance for the CMOS nano-electronic technologies, with the ability to provide films and alloys with electrical and optical properties to fit the desired device performance. The UV-ELA of amorphous (a-) and/or doped nano-crystalline (nc-) silicon films is based on the rapid (nanoseconds) formation of temperature profiles caused by laser radiation that is absorbed in the material and lead to crystallisation, diffusion in solid or even in liquid phase. To achieve the desired temperature profiles and to optimize the parameters involved in the processing of hydrogenated nanocrystalline silicon (nc-Si:H) films with the UV-ELA, a numerical analysis by finite element method (FEM) of a multilayer structure has been performed. The multilayer structures, consisting of thin alternating a-Si:H(10 nm) and n-doped nc-Si:H(60 nm) layers, deposited on a glass substrate, has also been experimentally analyzed. Temperature profiles caused by 193 nm radiation with 25

  5. Cost analysis and economic comparison for alternative fuel cycles in the heavy water cooled canadian reactor (CANDU)

    International Nuclear Information System (INIS)

    Three main options in a CANDU fuel cycle involve use of: (1) natural uranium (0.711 weight percent U-235) fuel, (2) slightly enriched uranium (1.2 weight percent U-235) fuel, and (3) recovered uranium (0.83 weight percent U-235) fuel from light water reactor spent fuel. ORIGEN-2 computer code was used to identify composition of the spent fuel for each option, including the standard LWR fuel (3.3 weight percent U-235). Uranium and plutonium credit calculations were performed using ORIGEN-2 output. WIMSD-5 computer code was used to determine maximum discharge burnup values for each case. For the 3 cycles selected (natural uranium, slightly enriched uranium, recovered uranium), levelized fuel cycle cost calculations are performed over the reactor lifetime of 40 years, using unit process costs obtained from literature. Components of the fuel cycle costs are U purchase, conversion, enrichment, fabrication, SF storage, SF disposal, and reprocessing where applicable. Cost parameters whose effects on the fuel cycle cost are to be investigated are escalation ratio, discount rate and SF storage time. Cost estimations were carried out using specially developed computer programs. Share of each cost component on the total cost was determined and sensitivity analysis was performed in order to show how a change in a main cost component affects the fuel cycle cost. The main objective of this study has been to find out the most economical option for CANDU fuel cycle by changing unit prices and cost parameters

  6. Analysis of alternatives for using cable bolts as primary support at two low-seam coal mines

    Institute of Scientific and Technical Information of China (English)

    Esterhuizen Gabriel S; Tulu Ihsan B

    2016-01-01

    Cable bolts are sometimes used in low-seam coal mines to provide support in difficult ground conditions. This paper describes cable bolting solutions at two low-seam coal mines in similar ground conditions. Both mines used support systems incorporating cable bolts as part of the primary support system. Two original cable bolt based support systems as well as two modified systems are evaluated to estimate their ability to prevent large roof falls. One of the support systems incorporated passive cable bolts, while the other used pre-tensioned cable bolts. The results and experience at the mines showed that the mod-ified systems provided improved stability over the original support systems. The presence of the cable bolts is the most important contribution to stability against large roof falls, rather than the details of the support pattern. It was also found that a heavy steel channel can improve the safety of the system because of the‘sling’ action it provides. Additionally, the analysis showed that fully-grouted rebar bolts load much earlier than the cable bolts, and pre-tensioning of the cable bolts can result in a more uniform distribution of loading in the roof.

  7. Thermodynamic Analysis of Actual Vapour Compression System with R12 and Its Eco-Friendly Alternatives Refrigerants

    Directory of Open Access Journals (Sweden)

    Vijay Singh Bisht

    2014-04-01

    Full Text Available This paper presents a theoretical performance study of a vapour compression refrigeration system with refrigerants R-12, R134a and R1234yf. A computational model based on energy first law analysis is presented for the investigation of the effects of evaporating temperatures, degree of subcooling, dead state temperatures and effectiveness of the liquid vapour heat exchanger on the relative capacity change index, coefficient of performance of the vapour compression refrigeration cycle. RCI (relative capacity change index of the system is highest for R1234yf and with increase in degree of subcooling; R1234yf has the highest percentage increase in COP. The total compressor work requirement for system is highest with R134a. R1234yf is the only refrigerants of all the refrigerants used in present work that satisfy MAC directive (2006/40/EG because of GWP value less than 150. From these results, it is indicated that R1234yf is the refrigerant for future.

  8. lociNGS: a lightweight alternative for assessing suitability of next-generation loci for evolutionary analysis.

    Directory of Open Access Journals (Sweden)

    Sarah M Hird

    Full Text Available Genomic enrichment methods and next-generation sequencing produce uneven coverage for the portions of the genome (the loci they target; this information is essential for ascertaining the suitability of each locus for further analysis. lociNGS is a user-friendly accessory program that takes multi-FASTA formatted loci, next-generation sequence alignments and demographic data as input and collates, displays and outputs information about the data. Summary information includes the parameters coverage per locus, coverage per individual and number of polymorphic sites, among others. The program can output the raw sequences used to call loci from next-generation sequencing data. lociNGS also reformats subsets of loci in three commonly used formats for multi-locus phylogeographic and population genetics analyses - NEXUS, IMa2 and Migrate. lociNGS is available at https://github.com/SHird/lociNGS and is dependent on installation of MongoDB (freely available at http://www.mongodb.org/downloads. lociNGS is written in Python and is supported on MacOSX and Unix; it is distributed under a GNU General Public License.

  9. Lean systems approaches to health technology assessment: a patient-focused alternative to cost-effectiveness analysis.

    Science.gov (United States)

    Bridges, John F P

    2006-12-01

    Many countries now use health technology assessment (HTA) to review new and emerging technologies, especially with regard to reimbursement, pricing and/or clinical guidelines. One of the common, but not universal, features of these systems is the use of economic evaluation, normally cost-effectiveness analysis (CEA), to confirm that new technologies offer value for money. Many have criticised these systems as primarily being concerned with cost containment, rather than advancing the interests of patients or innovators. This paper calls into question the underlying principles of CEA by arguing that value in the healthcare system may in fact be unconstrained. It is suggested that 'lean management principles' can be used not only to trim waste from the health system, but as a method of creating real incentives for innovation and value creation. Following the lean paradigm, this value must be defined purely from the patients' perspective, and the entire health system needs to work towards the creation of such value. This paper offers as a practical example a lean approach to HTA, arguing that such an approach would lead to better incentives for innovation in health, as well as more patient-friendly outcomes in the long run. PMID:23389493

  10. Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function.

    Science.gov (United States)

    Lu, Xuefeng; Li, Ling; Wu, Rui; Feng, Xiaohua; Li, Zhimin; Yang, Heyi; Wang, Canhui; Guo, Hua; Galkin, Andrey; Herzberg, Osnat; Mariano, Patrick S; Martin, Brian M; Dunaway-Mariano, Debra

    2006-01-31

    L-Arginine deiminase from Pseudomonas aeruginosa (PaADI) catalyzes the hydrolysis of arginine to citrulline and ammonia. PaADI belongs to the guanidino group-modifying enzyme superfamily (GMSF), which conserves backbone fold and a Cys-, His-, and Asp-based catalytic core. In this paper the contributions made by the PaADI core residues Cys406, His278, and Asp166 and the contribution from the neighboring Asp280 (conserved in most but not all GMSF members) to catalysis of the formation and hydrolysis of the Cys406-alkyluronium intermediate were accessed by kinetic analysis of site-directed mutants. In addition, solution hydrolysis in a chemical model of the S-alkylthiouronium intermediate was examined to reveal the importance of general base catalysis in the enzymatic reaction. Substitutions of the active site gating residue Arg401, the l-arginine C(alpha)NH(3)(+)(COO(-)) binding residues, Arg185, Arg243, and Asn160, or the His278 hydrogen bond partner, Glu224, were found to cause dramatic reductions in the enzyme turnover rate. These results are interpreted to suggest that electrostatic interactions play a dominant role in PaADI catalysis. Structural variations observed in P. aeruginosa GMSF enzymes PaADI, agmatine deiminase (PaAgDI), and N(omega),N(omega)-dimethylarginine dimethylaminohydrolase (PaDDAH) indicate an early divergence of the encoding genes. Arginine analogues that are known substrates for PaAgDI and PaDDAH were tested with PaADI to define clear boundaries of biochemical function in the three hydrolases. The conservation of a catalytic core associated with the common chemical function and the divergence of substrate-binding residues (as well as one key catalytic residue) to expand the substrate range provide insight into the evolution of the catalysts that form the GMSF. PMID:16430212

  11. Alternative CHCA-based matrices for the analysis of low molecular weight compounds by UV-MALDI-tandem mass spectrometry.

    Science.gov (United States)

    Porta, Tiffany; Grivet, Chantal; Knochenmuss, Richard; Varesio, Emmanuel; Hopfgartner, Gérard

    2011-02-01

    Analysis of low molecular weight compounds (LMWC) in complex matrices by vacuum matrix-assisted laser desorption/ionization (MALDI) often suffers from matrix interferences, which can severely degrade limits of quantitation. It is, therefore, useful to have available a range of suitable matrices, which exhibit complementary regions of interference. Two newly synthesized α-cyanocinnamic acid derivatives are reported here; (E)-2-cyano-3-(naphthalen-2-yl)acrylic acid (NpCCA) and (2E)-3-(anthracen-9-yl)-2-cyanoprop-2enoic acid (AnCCA). Along with the commonly used α-cyano-4-hydroxycinnamic acid (CHCA), and the recently developed 4-chloro-α-cyanocinnamic acid (Cl-CCA) matrices, these constitute a chemically similar series of matrices covering a range of molecular weights, and with correspondingly differing ranges of spectral interference. Their performance was compared by measuring the signal-to-noise ratios (S/N) of 47 analytes, mostly pharmaceuticals, with the different matrices using the selected reaction monitoring (SRM) mode on a triple quadrupole instrument equipped with a vacuum MALDI source. AnCCA, NpCCA and Cl-CCA were found to offer better signal-to-noise ratios in SRM mode than CHCA, but Cl-CCA yielded the best results for 60% of the compounds tested. To better understand the relative performance of this matrix series, the proton affinities (PAs) were measured using the kinetic method. Their relative values were: AnCCA > CHCA > NpCCA > Cl-CCA. This ordering is consistent with the performance data. The synthesis of the new matrices is straightforward and they provide (1) tunability of matrix background interfering ions and (2) enhanced analyte response for certain classes of compounds. PMID:21259393

  12. Microbial community analysis and identification of alternative host-specific fecal indicators in fecal and river water samples using pyrosequencing.

    Science.gov (United States)

    Jeong, Ju-Yong; Park, Hee-Deung; Lee, Kyong-Hee; Weon, Hang-Yeon; Ka, Jong-Ok

    2011-08-01

    It is important to know the comprehensive microbial communities of fecal pollution sources and receiving water bodies for microbial source tracking. Pyrosequencing targeting the V1-V3 hypervariable regions of the 16S rRNA gene was used to investigate the characteristics of bacterial and Bacteroidales communities in major fecal sources and river waters. Diversity analysis indicated that cow feces had the highest diversities in the bacterial and Bacteroidales group followed by the pig sample, with human feces having the lowest value. The Bacteroidales, one of the potential fecal indicators, totally dominated in the fecal samples accounting for 31%-52% of bacterial sequences, but much less (0.6%) in the river water. Clustering and Venn diagram analyses showed that the human sample had a greater similarity to the pig sample in the bacterial and Bacteroidales communities than to samples from other hosts. Traditional fecal indicators, i.e., Escherichia coli, were detected in the human and river water samples at very low rates and Clostridium perfringens and enterococci were not detected in any samples. Besides the Bacteroidales group, some microorganisms detected in the specific hosts, i.e., Parasutterella excrementihominis, Veillonella sp., Dialister invisus, Megamonas funiformis, and Ruminococcus lactaris for the human and Lactobacillus amylovorus and Atopostipes sp. for the pig, could be used as potential host-specific fecal indicators. These microorganisms could be used as multiple fecal indicators that are not dependent on the absence or presence of a single indicator. Monitoring for multiple indicators that are highly abundant and host-specific would greatly enhance the effectiveness of fecal pollution source tracking. PMID:21887641

  13. Intensity-based analysis of dual-color gene expression data as an alternative to ratio-based analysis to enhance reproducibility

    OpenAIRE

    Verhaagen Joost; Smeets Serge J; Brakenhoff Ruud H; Ylstra Bauke; Bossers Koen; van de Wiel Mark A

    2010-01-01

    Abstract Background Ratio-based analysis is the current standard for the analysis of dual-color microarray data. Indeed, this method provides a powerful means to account for potential technical variations such as differences in background signal, spot size and spot concentration. However, current high density dual-color array platforms are of very high quality, and inter-array variance has become much less pronounced. We therefore raised the question whether it is feasible to use an intensity...

  14. Bioaccessibility of some elements from wheatgrass ( Triticum aestivum L.) by in-vitro gastrointestinal digestion combined with neutron activation analysis using ammonium bicarbonate as an alternate base

    International Nuclear Information System (INIS)

    Studies on bioaccessibility of elements were carried out by in-vitro gastrointestinal digestion simulation method combined with neutron activation analysis (NAA) using NH4HCO3 as an alternate base to commonly used base of NaHCO3. The effect of two bases namely NaHCO3 and NH4HCO3 on the bioaccessibility of the elements namely Br, Fe, K, La, Na, Rb, Sm and Zn from wheat seeds, fresh wheatgrass and commercial wheatgrass tablet was investigated. The bioaccessible concentrations of the elements were determined by neutron activation analysis (NAA). The bioaccessible concentrations of samples digested using NH4HCO3 were found to be higher by 10-15% for most of the elements than that observed using NaHCO3. In the case of fresh wheatgrass, the differences were as high as 50%. The present study indicated that NH4HCO3 can be used as a base instead of NaHCO3 in in-vitro gastrointestinal digestion simulation method. (author)

  15. Flow cytometry and adenosine tri-phosphate analysis: alternative possibilities to evaluate major bacteriological changes in drinking water treatment and distribution systems.

    Science.gov (United States)

    Vital, Marius; Dignum, Marco; Magic-Knezev, Aleksandra; Ross, Petra; Rietveld, Luuk; Hammes, Frederik

    2012-10-01

    An ever-growing need exists for rapid, quantitative and meaningful methods to quantify and characterize the effect of different treatment steps on the microbiological processes and events that occur during drinking water treatment and distribution. Here we compared cultivation-independent flow cytometry (FCM) and adenosine tri-phosphate (ATP) analysis with conventional cultivation-based microbiological methods, on water samples from two full-scale treatment and distribution systems. The two systems consist of nearly identical treatment trains, but their raw water quality and pre-treatment differed significantly. All of the drinking water treatment processes affected the microbiological content of the water considerably, but once treated, the finished water remained remarkably stable throughout the distribution system. Both the FCM and ATP data were able to describe the microbiology of the systems accurately, providing meaningful process data when combined with other parameters such as dissolved organic carbon analysis. Importantly, the results highlighted a complimentary value of the two independent methods: while similar trends were mostly observed, variations in ATP-per-cell values between water samples were adequately explained by differences in the FCM fingerprints of the samples. This work demonstrates the value of alternative microbial methods for process/system control, optimization and routine monitoring of the general microbial quality of water during treatment and distribution. PMID:22763289

  16. 1H NMR metabolomic study of auxotrophic starvation in yeast using Multivariate Curve Resolution-Alternating Least Squares for Pathway Analysis

    Science.gov (United States)

    Puig-Castellví, Francesc; Alfonso, Ignacio; Piña, Benjamin; Tauler, Romà

    2016-01-01

    Disruption of specific metabolic pathways constitutes the mode of action of many known toxicants and it is responsible for the adverse phenotypes associated to human genetic defects. Conversely, many industrial applications rely on metabolic alterations of diverse microorganisms, whereas many therapeutic drugs aim to selectively disrupt pathogens’ metabolism. In this work we analyzed metabolic changes induced by auxotrophic starvation conditions in yeast in a non-targeted approach, using one-dimensional proton Nuclear Magnetic Resonance spectroscopy (1H NMR) and chemometric analyses. Analysis of the raw spectral datasets showed specific changes linked to the different stages during unrestricted yeast growth, as well as specific changes linked to each of the four tested starvation conditions (L-methionine, L-histidine, L-leucine and uracil). Analysis of changes in concentrations of more than 40 metabolites by Multivariate Curve Resolution – Alternating Least Squares (MCR-ALS) showed the normal progression of key metabolites during lag, exponential and stationary unrestricted growth phases, while reflecting the metabolic blockage induced by the starvation conditions. In this case, different metabolic intermediates accumulated over time, allowing identification of the different metabolic pathways specifically affected by each gene disruption. This synergy between NMR metabolomics and molecular biology may have clear implications for both genetic diagnostics and drug development. PMID:27485935

  17. (1)H NMR metabolomic study of auxotrophic starvation in yeast using Multivariate Curve Resolution-Alternating Least Squares for Pathway Analysis.

    Science.gov (United States)

    Puig-Castellví, Francesc; Alfonso, Ignacio; Piña, Benjamin; Tauler, Romà

    2016-01-01

    Disruption of specific metabolic pathways constitutes the mode of action of many known toxicants and it is responsible for the adverse phenotypes associated to human genetic defects. Conversely, many industrial applications rely on metabolic alterations of diverse microorganisms, whereas many therapeutic drugs aim to selectively disrupt pathogens' metabolism. In this work we analyzed metabolic changes induced by auxotrophic starvation conditions in yeast in a non-targeted approach, using one-dimensional proton Nuclear Magnetic Resonance spectroscopy ((1)H NMR) and chemometric analyses. Analysis of the raw spectral datasets showed specific changes linked to the different stages during unrestricted yeast growth, as well as specific changes linked to each of the four tested starvation conditions (L-methionine, L-histidine, L-leucine and uracil). Analysis of changes in concentrations of more than 40 metabolites by Multivariate Curve Resolution - Alternating Least Squares (MCR-ALS) showed the normal progression of key metabolites during lag, exponential and stationary unrestricted growth phases, while reflecting the metabolic blockage induced by the starvation conditions. In this case, different metabolic intermediates accumulated over time, allowing identification of the different metabolic pathways specifically affected by each gene disruption. This synergy between NMR metabolomics and molecular biology may have clear implications for both genetic diagnostics and drug development. PMID:27485935

  18. Life-Cycle Cost and Risk Analysis of Alternative Configurations for Shipping Low-Level Radioactive Waste to the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    PM Daling; SB Ross; BM Biwer

    1999-12-17

    The Nevada Test Site (NTS) is a major receiver of low-level radioactive waste (LLW) for disposal. Currently, all LLW received at NTS is shipped by truck. The trucks use highway routes to NTS that pass through the Las Vegas Valley and over Hoover Dam, which is a concern of local stakeholder groups in the State of Nevada. Rail service offers the opportunity to reduce transportation risks and costs, according to the Waste Management Programmatic Environmental Impact Statement (WM-PEIS). However, NTS and some DOE LLW generator sites are not served with direct rail service so intermodal transport is under consideration. Intermodal transport involves transport via two modes, in this case truck and rail, from the generator sites to NTS. LLW shipping containers would be transferred between trucks and railcars at intermodal transfer points near the LLW generator sites, NTS, or both. An Environmental Assessment (EA)for Intermodal Transportation of Low-Level Radioactive Waste to the Nevada Test Site (referred to as the NTSIntermodal -M) has been prepared to determine whether there are environmental impacts to alterations to the current truck routing or use of intermodal facilities within the State of Nevada. However, an analysis of the potential impacts outside the State of Nevada are not addressed in the NTS Intermodal EA. This study examines the rest of the transportation network between LLW generator sites and the NTS and evaluates the costs, risks, and feasibility of integrating intermodal shipments into the LLW transportation system. This study evaluates alternative transportation system configurations for NTS approved and potential generators based on complex-wide LLW load information. Technical judgments relative to the availability of DOE LLW generators to ship from their sites by rail were developed. Public and worker risk and life-cycle cost components are quantified. The study identifies and evaluates alternative scenarios that increase the use of rail (intermodal

  19. Life-Cycle Cost and Risk Analysis of Alternative Configurations for Shipping Low-Level Radioactive Waste to the Nevada Test Site

    International Nuclear Information System (INIS)

    The Nevada Test Site (NTS) is a major receiver of low-level radioactive waste (LLW) for disposal. Currently, all LLW received at NTS is shipped by truck. The trucks use highway routes to NTS that pass through the Las Vegas Valley and over Hoover Dam, which is a concern of local stakeholder groups in the State of Nevada. Rail service offers the opportunity to reduce transportation risks and costs, according to the Waste Management Programmatic Environmental Impact Statement (WM-PEIS). However, NTS and some DOE LLW generator sites are not served with direct rail service so intermodal transport is under consideration. Intermodal transport involves transport via two modes, in this case truck and rail, from the generator sites to NTS. LLW shipping containers would be transferred between trucks and railcars at intermodal transfer points near the LLW generator sites, NTS, or both. An Environmental Assessment (EA)for Intermodal Transportation of Low-Level Radioactive Waste to the Nevada Test Site (referred to as the NTSIntermodal -M) has been prepared to determine whether there are environmental impacts to alterations to the current truck routing or use of intermodal facilities within the State of Nevada. However, an analysis of the potential impacts outside the State of Nevada are not addressed in the NTS Intermodal EA. This study examines the rest of the transportation network between LLW generator sites and the NTS and evaluates the costs, risks, and feasibility of integrating intermodal shipments into the LLW transportation system. This study evaluates alternative transportation system configurations for NTS approved and potential generators based on complex-wide LLW load information. Technical judgments relative to the availability of DOE LLW generators to ship from their sites by rail were developed. Public and worker risk and life-cycle cost components are quantified. The study identifies and evaluates alternative scenarios that increase the use of rail (intermodal

  20. State alternative route designations

    Energy Technology Data Exchange (ETDEWEB)

    1989-07-01

    Pursuant to the Hazardous Materials Transportation Act (HMTA), the Department of Transportation (DOT) has promulgated a comprehensive set of regulations regarding the highway transportation of high-level radioactive materials. These regulations, under HM-164 and HM-164A, establish interstate highways as the preferred routes for the transportation of radioactive materials within and through the states. The regulations also provide a methodology by which a state may select alternative routes. First,the state must establish a ``state routing agency,`` defined as an entity authorized to use the state legal process to impose routing requirements on carriers of radioactive material (49 CFR 171.8). Once identified, the state routing agency must select routes in accordance with Large Quantity Shipments of Radioactive Materials or an equivalent routing analysis. Adjoining states and localities should be consulted on the impact of proposed alternative routes as a prerequisite of final route selection. Lastly, the states must provide written notice of DOT of any alternative route designation before the routes are deemed effective.

  1. State alternative route designations

    Energy Technology Data Exchange (ETDEWEB)

    1989-07-01

    Pursuant to the Hazardous Materials Transportation Act (HMTA), the Department of Transportation (DOT) has promulgated a comprehensive set of regulations regarding the highway transportation of high-level radioactive materials. These regulations, under HM-164 and HM-164A, establish interstate highways as the preferred routes for the transportation of radioactive materials within and through the states. The regulations also provide a methodology by which a state may select alternative routes. First,the state must establish a state routing agency,'' defined as an entity authorized to use the state legal process to impose routing requirements on carriers of radioactive material (49 CFR 171.8). Once identified, the state routing agency must select routes in accordance with Large Quantity Shipments of Radioactive Materials or an equivalent routing analysis. Adjoining states and localities should be consulted on the impact of proposed alternative routes as a prerequisite of final route selection. Lastly, the states must provide written notice of DOT of any alternative route designation before the routes are deemed effective.

  2. Assessment of MELCOR-1.8.5 versus different versions of SCDAP/RELAP5 MOD-3.3 with lower head creep rupture analysis of alternative accident sequences of the Three Mile Island Unit 2

    International Nuclear Information System (INIS)

    The objective of this analysis is to assess current versions of MELCOR 1.8.5-RG against 2 different versions of SCDAP/RELAP5 MOD 3.3 (SR5m33kz and SR5m33bf) with the same Henry-Fauske choked flow model. This lower head creep rupture analysis considers 2 TMI-2 (Three Mile Island - Unit 2) alternative accident sequences: (1) TMI-2 alternative accident sequence-1, and (2) TMI-2 alternative accident sequence-2. Significant findings of the analysis include: (1) the TMI-2 lower head wall fails by creep rupture with either deactivations or activations of the High Pressure Injection System; (2) for the TMI-2 alternative accident sequence-1 the time to creep rupture calculated with MELCOR 1.8.5-RG and SCDAP/RELAP5 MOD-3.3 agrees reasonably; (3) the calculation with MELCOR for the TMI-2 alternative accident sequence-1 predicts that the lower head wall failure occurred earlier than penetration failure, while MELCOR predicts the opposite for the TMI-2 alternative accident sequence-2; (4) calculation with MELCOR for TMI-2 alternative accident sequence-2 shows that when the lower head wall fails the temperature calculated with MELCOR is 1810.9 K, which exceeds the melting temperature of 1789 K for carbon steel; (5) calculations with both SR5m33kz and SR5m33bf for both TMI-2 alternative accident sequences indicate that different lower head wall locations fail rapidly one after another by a delay of a few seconds, while this is not the case for MELCOR

  3. Alternative fuels for vehicles; Alternative drivmidler

    Energy Technology Data Exchange (ETDEWEB)

    2012-02-15

    Up until 2020 and onwards the analysis indicates that especially electricity, biogas and natural gas as propellants is economically attractive compared to conventional gasoline and diesel while other fuels have the same or higher costs for petrol and diesel. Especially biogas and electricity will also offer significant reductions in CO{sub 2} emissions, but also hydrogen, methanol, DME and to a lesser extent the second generation bioethanol and most of the other alternative fuels reduce CO{sub 2} emissions. Use of the traditional food-based first generation biofuels involves, at best, only modest climate benefits if land use changes are counted, and at worst, significant negative climate effects. Natural gas as a propellant involves a moderate climate gain, but may play a role for building infrastructure and market for gaseous fuels in large fleets, thereby contributing to the phasing in of biogas for transport. The electric-based automotive fuels are the most effective due to a high efficiency of the engine and an increasing proportion of wind energy in the electricity supply. The methanol track also has a relatively high efficiency. Among the others, the track based on diesel engines (biodiesel) is more effective than the track based on gasoline/Otto engines (gas and ethanol) as a result of the diesel engine's better efficiency. For the heavy vehicles all the selected alternative fuels to varying degrees reduce emissions of CO{sub 2}, particularly DME based on wood. The only exception to this is - as for passenger cars - the propellant synthetic diesel based on coal. (LN).

  4. TANK SPACE ALTERNATIVES ANALYSIS REPORT

    Energy Technology Data Exchange (ETDEWEB)

    TURNER DA; KIRCH NW; WASHENFELDER DJ; SCHAUS PS; WODRICH DD; WIEGMAN SA

    2010-04-27

    This report addresses the projected shortfall of double-shell tank (DST) space starting in 2018. Using a multi-variant methodology, a total of eight new-term options and 17 long-term options for recovering DST space were evaluated. These include 11 options that were previously evaluated in RPP-7702, Tank Space Options Report (Rev. 1). Based on the results of this evaluation, two near-term and three long-term options have been identified as being sufficient to overcome the shortfall of DST space projected to occur between 2018 and 2025.

  5. Space shuttle/food system. Volume 2, Appendix C: Food cooling techniques analysis. Appendix D: Package and stowage: Alternate concepts analysis

    Science.gov (United States)

    1974-01-01

    The relative penalties associated with various techniques for providing an onboard cold environment for storage of perishable food items, and for the development of packaging and vehicle stowage parameters were investigated in terms of the overall food system design analysis of space shuttle. The degrees of capability for maintaining both a 40 F to 45 F refrigerated temperature and a 0 F and 20 F frozen environment were assessed for the following cooling techniques: (1) phase change (heat sink) concept; (2) thermoelectric concept; (3) vapor cycle concept; and (4) expendable ammonia concept. The parameters considered in the analysis were weight, volume, and spacecraft power restrictions. Data were also produced for packaging and vehicle stowage parameters which are compatible with vehicle weight and volume specifications. Certain assumptions were made for food packaging sizes based on previously generated space shuttle menus. The results of the study are shown, along with the range of meal choices considered.

  6. Matrix-free analysis of selected benzodiazepines in human serum samples using alternating trilinear decomposition modeling of fast liquid chromatography diode array detection data.

    Science.gov (United States)

    Vosough, Maryam; Iravani, Negar J

    2016-02-01

    This paper describes the development and validation of a simple and efficient bioanalytical procedure for simultaneous determination of alprazolam, clonazepam, diazepam in human serum samples using high performance liquid chromatography with photodiode-array detection, regarding a fast elution methodology in 4 min. Briefly, this method consists of a simple liquid extraction step of serum samples followed by HPLC analysis on a C18 column. After confirming the absence of matrix effect, an external standard methodology has been applied for quantification purposes. Due to the presence of serum endogenous components as uncalibrated components in the sample, the second-order calibration based on alternating trilinear decomposition has been applied on a set of absorbance matrices collected as a function of retention time and wavelengths. Acceptable resolution and quantification results were achieved in the presence of matrix interferences and the second-order advantage was fully exploited. The average recoveries for alprazolam, clonazepam and diazepam were 89.1%, 96.3% and 94.7% and relative standard deviation values for intra- and inter-day precision were equal or lower than 8.1% and 9.4%, respectively. The developed method enabled us to determine the analytes in the various serum samples in the presence of overlapped profiles, while keeping experimental time and extraction step at the minimum. PMID:26653472

  7. Identification and functional analysis of porcine basic helix-loop-helix transcriptional factor 3 (TCF3) and its alternative splicing isoforms.

    Science.gov (United States)

    Yang, Fan; Wang, Ning; Liu, Yajun; Wang, Huayan

    2016-04-01

    The transcription factor 3 (TCF3) is a basic helix-loop-helix transcription factor and is essential for lymphocyte development and epithelial-mesenchymal transition. The splicing isoform, genomic organization and physiological roles of TCF3 have not been elucidated well in pig. Based on RNA-seq database, four alternative splicing isoforms were identified. Splicing isoforms TCF3(E12), TCF3(E47), and TCF3A expressed globally in porcine tissues, but TCF3B mainly expressed in spleen and endoderm derived tissues, such as pancreas and lung. The functional analysis showed that TCF3(E12), TCF3(E47), and TCF3B were translocated exclusively into nuclei, yet TCF3A was distributed in cytoplasm. The investigation of clinical specimens showed that TCF3 expression was significantly reduced in spleen tissues that were infected by classical swine fever virus (CSFV). This study is for the first time to report two novel splicing isoforms TCF3A and TCF3B, which may play an important role in lymphocyte maturation and have the correlation with CSFV evasion. PMID:27033898

  8. Outcomes analysis of an alternative formulation of PEGylated liposomal doxorubicin in recurrent epithelial ovarian carcinoma during the drug shortage era [Corrigendum

    Directory of Open Access Journals (Sweden)

    Berger JL

    2015-03-01

    Full Text Available Berger JL, Smith A, Zorn KK, et al. Onco Targets Ther. 2014;7:1409–1413.It has been brought to our attention that there are two pharmaceutical companies that market drugs with the name ‘lipodox’ and we erroneously refer to the product used in our current study-Outcomes analysis of an alternative formulation of PEGylated liposomal doxorubicin in recurrent epithelial ovarian carcinoma during the drug shortage era. by the trade name Lipo-dox®, a drug produced by TTY Biopharm Co. Ltd, when the Sun Pharma product is Lipodox. Lipo-Dox® utilizes a different liposomal particle than Doxil®, DSCP versus HSCP. Due to the similarity of the drug names, we were under the mistaken impression that Sun Pharma’s Lipodox utilized the DSCP liposome. We postulated that this might be related to the poor clinical outcomes seen in our population. It is now clear that Lipodox utilizes the same liposome as Doxil® and this is not a relevant point of discussion. The authors would like to let the readers know that Lipodox uses HSCP as the liposome and this should be corrected in the manuscript. The patients in our current study were all treated with Lipodox, and this drug uses HSCP as the liposome.

  9. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.

    Science.gov (United States)

    Shyn, S I; Shi, J; Kraft, J B; Potash, J B; Knowles, J A; Weissman, M M; Garriock, H A; Yokoyama, J S; McGrath, P J; Peters, E J; Scheftner, W A; Coryell, W; Lawson, W B; Jancic, D; Gejman, P V; Sanders, A R; Holmans, P; Slager, S L; Levinson, D F; Hamilton, S P

    2011-02-01

    We report a genome-wide association study (GWAS) of major depressive disorder (MDD) in 1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and 1636 screened controls. No genome-wide evidence for association was detected. We also carried out a meta-analysis of three European-ancestry MDD GWAS data sets: STAR*D, Genetics of Recurrent Early-onset Depression and the publicly available Genetic Association Information Network-MDD data set. These data sets, totaling 3957 cases and 3428 controls, were genotyped using four different platforms (Affymetrix 6.0, 5.0 and 500 K, and Perlegen). For each of 2.4 million HapMap II single-nucleotide polymorphisms (SNPs), using genotyped data where available and imputed data otherwise, single-SNP association tests were carried out in each sample with correction for ancestry-informative principal components. The strongest evidence for association in the meta-analysis was observed for intronic SNPs in ATP6V1B2 (P=6.78 x 10⁻⁷), SP4 (P=7.68 x 10⁻⁷) and GRM7 (P=1.11 x 10⁻⁶). Additional exploratory analyses were carried out for a narrower phenotype (recurrent MDD with onset before age 31, N=2191 cases), and separately for males and females. Several of the best findings were supported primarily by evidence from narrow cases or from either males or females. On the basis of previous biological evidence, we consider GRM7 a strong MDD candidate gene. Larger samples will be required to determine whether any common SNPs are significantly associated with MDD. PMID:20038947

  10. Ethyl-bridged hybrid column as an efficient alternative for HPLC analysis of plasma amino acids by pre-column derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate.

    Science.gov (United States)

    Castellanos, Mar; Van Eendenburg, Cecile Van; Gubern, Carme; Sanchez, Juan M

    2016-09-01

    Conventional C18 silica columns have proven to be useful for the analysis of amino acids (AA) from protein hydrolysates but undesirable peak overlapping is usually found when analyzing body fluids given that a large number of AAs are present in the samples. As an alternative to silica packings, an ethyl-bridged packing for reversed-phase liquid chromatography of derivatized AAs with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) has been evaluated. The new packing material improves the separation efficiency allowing better separations when analyzing biological fluids. Moreover, this packing has advantages for routine AA analysis, such as a decrease in the total running time and an increase in the life-time of the columns. The pH of the mobile phase has a significant effect on the elution behavior of the AQC hydrolysis product (AMQ) and on the AA derivatives. It is not possible to elute AMQ before detecting the first AA derivative, which requires an accurate adjustment of the pH in the range of 5.30-5.35 to obtain good separation and resolution for the most polar compounds. Under the conditions proposed, it is possible to separate all AAs except the Gly-Gln pair, which is not a problem when hydrolyzed samples are analyzed. The AMQ-Ser pair requires either the use of a different mobile phase pH for its baseline separation or the use of fluorescence detection. Two different procedures for protein removal from plasma samples have been evaluated, solvent precipitation and ultrafiltration (UF) and it has been found that UF gives better results as no significant losses of AAs were observed. The validation of the proposed method with UV detection gives method detection limits in the range of 8-12μM, with repeatability values<8% (n=6) and inter-day precision in plasma samples ranging from 4 to 13% (n=4). PMID:27428457

  11. Multi-batch catfish production and economic analysis using alternative low-cost diets with corn gluten feed and traditional diets with meat-and-bone meal

    Science.gov (United States)

    We conducted concurrent feeding trials for one growing season with channel catfish in ponds in Mississippi and Arkansas to evaluate the production and economic effects of alternative (low-cost) feeds containing 28 or 32% protein and alternative (corn gluten feed) or traditional (porcine meat, bone a...

  12. A systematic review-meta-analysis of primary research investigating the effect of selected alternative treatments on gastrointestinal nematodes in sheep under field conditions.

    Science.gov (United States)

    Mederos, A; Waddell, L; Sánchez, J; Kelton, D; Peregrine, A S; Menzies, P; VanLeeuwen, J; Rajić, A

    2012-04-01

    Selected alternative treatments for preventing or controlling gastrointestinal nematodes (GIN) in sheep under field conditions were evaluated using a systematic review-meta-analysis methodology. Forty-three publications reporting 51 studies (21 controlled studies (CS) and 30 challenge studies (ChS)) and 85 unique treatment comparisons were included in the review. The alternative treatment categories were nutraceuticals (28 studies), breeding for genetic resistance (12), nutritional manipulation (6), homeopathies (2), administration of copper oxide wire particles (2), and biological control (1). Random effect meta-analyses (MA) and meta-regression were performed with the natural logarithm of the difference in means (lnMD) between the control and treatment groups, for fecal egg counts per gram of wet feces (FEC), worm counts (WC) or fecal egg counts per gram of dry matter (FECDM) as the outcome. Treatment effect estimates (lnMD) were back-transformed to their count ratios (CR), a relative measure of effect for controlled versus treated groups, for presentation of results. Significant heterogeneity was observed for both CS and ChS that evaluated nutraceuticals, genetic resistance and nutrition treatments. MA of ChS that investigated nutraceuticals resulted in a significant overall CR of 1.62 (P<0.01) and 1.64 (P<0.01) for FEC and FECDM, respectively and a marginal significant CR of 1.14 (P=0.06) for WC, all favoring the treated groups. MA of CS and ChS that investigated genetic resistance resulted in a significant overall CR of 5.89 and 15.42, respectively (P<0.01), again favoring treated groups. MA of CS that investigated homeopathies with FEC as an outcome were homogenous (I(2)=0.0%) and resulted in a non-significant pooled CR of 1.61. ChS investigating copper oxide wire particle treatments and WC as an outcome, were homogenous (I(2)=0.0%) and had a marginally significant pooled CR of 1.68 (P=0.06). Publication bias was observed for ChS with WC outcomes, indicating

  13. Assessment of costs and benefits of flexible and alternative fuel use in the U.S. transportation sector. Technical report fourteen: Market potential and impacts of alternative fuel use in light-duty vehicles -- A 2000/2010 analysis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-01-01

    In this report, estimates are provided of the potential, by 2010, to displace conventional light-duty vehicle motor fuels with alternative fuels--compressed natural gas (CNG), liquefied petroleum gas (LPG), methanol from natural gas, ethanol from grain and from cellulosic feedstocks, and electricity--and with replacement fuels such as oxygenates added to gasoline. The 2010 estimates include the motor fuel displacement resulting both from government programs (including the Clean Air Act and EPACT) and from potential market forces. This report also provides an estimate of motor fuel displacement by replacement and alterative fuels in the year 2000. However, in contrast to the 2010 estimates, the year 2000 estimate is restricted to an accounting of the effects of existing programs and regulations. 27 figs., 108 tabs.

  14. Cost-effectiveness analysis of the direct and indirect impact of intranasal live attenuated influenza vaccination strategies in children: alternative country profiles

    Science.gov (United States)

    Gibson, Edward; Begum, Najida; Martinón-Torres, Federico; Safadi, Marco Aurélio; Sackeyfio, Alfred; Hackett, Judith; Rajaram, Sankarasubramanian

    2016-01-01

    Background Influenza poses a significant burden on healthcare systems and society, with under-recognition in the paediatric population. Existing vaccination policies (largely) target the elderly and other risk groups where complications may arise. Objective The goal of this study was to evaluate the cost-effectiveness of annual paediatric vaccination (in 2–17-year-olds) with live attenuated influenza vaccination (LAIV), as well as the protective effect on the wider population in England and Wales (base). The study aimed to demonstrate broad applications of the model in countries where epidemiological and transmission data is limited and that have sophisticated vaccination policies (Brazil, Spain, and Taiwan). Methods The direct and indirect impact of LAIV in the paediatric cohort was simulated using an age-stratified dynamic transmission model over a 5-year time horizon of daily cycles and applying discounting of 3.5% in the base case. Pre-existing immunity structure was based on a 1-year model run. Sensitivity analyses were conducted. Results In the base case for England and Wales, the annual paediatric strategy with LAIV was associated with improvements in influenza-related events and quality-adjusted life years (QALYs) lost, yielding an incremental cost per QALY of £6,208. The model was robust to change in the key input parameters. The probabilistic analysis demonstrated LAIV to be cost effective in more than 99% of iterations, assuming a willingness-to-pay threshold of £30,000. Incremental costs per QALY for Brazil were £2,817, and for the cases of Spain and Taiwan the proposed strategy was dominant over the current practice. Conclusion In addition to existing policies, annual paediatric vaccination using LAIV provides a cost-effective strategy that offers direct and indirect protection in the wider community. Paediatric vaccination strategies using LAIV demonstrated clinical and economic benefits over alternative (current vaccination) strategies in

  15. Sequence Analysis and Potentials of the Native RbcS Promoter in the Development of an Alternative Eukaryotic Expression System Using Green Microalga Ankistrodesmus convolutus

    Directory of Open Access Journals (Sweden)

    Suhaimi Napis

    2012-02-01

    Full Text Available The availability of highly active homologous promoters is critical in the development of a transformation system and improvement of the transformation efficiency. To facilitate transformation of green microalga Ankistrodesmus convolutus which is considered as a potential candidate for many biotechnological applications, a highly-expressed native promoter sequence of ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit (AcRbcS has been used to drive the expression of β-glucuronidase (gusA gene in this microalga. Besides the determination of the transcription start site by 5¢-RACE, sequence analysis revealed that AcRbcS promoter contained consensus TATA-box and several putative cis-acting elements, including some representative light-regulatory elements (e.g., G-box, Sp1 motif and SORLIP2, which confer light responsiveness in plants, and several potential conserved motifs (e.g., CAGAC-motif, YCCYTGG-motifs and CACCACA-motif, which may be involved in light responsiveness of RbcS gene in green microalgae. Using AcRbcS promoter::gusA translational fusion, it was demonstrated that this promoter could function as a light-regulated promoter in transgenic A. convolutus, which suggested that the isolated AcRbcS promoter was a full and active promoter sequence that contained all cis-elements required for developmental and light-mediated control of gene expression, and this promoter can be used to drive the expression of heterologous genes in A. convolutus. This achievement therefore advances the development of A. convolutus as an alternative expression system for the production of recombinant proteins. This is the first report on development of gene manipulation system for unicellular green alga A. convolutus.

  16. A meta-analysis comparing the safety and efficacy of azithromycin over the alternate drugs used for treatment of uncomplicated enteric fever

    Directory of Open Access Journals (Sweden)

    N A Trivedi

    2012-01-01

    Full Text Available Background: Drug-resistant typhoid fever is a major clinical problem globally. Emergence of multidrug-resistant (MDR S. Typhi has complicated therapy by limiting treatment options. Objectives: A meta-analysis was planned to determine the strength of evidence supporting use of azithromycin over the alternate drugs available for treatment of uncomplicated typhoid fever. Materials and Methods: Studies were identified using electronic database such as MEDLINE and other data at the National Library of Medicine assessed using PUBMED search engine as well as Cochrane Clinical Trial Register. Randomized control trials (RCTs comparing azithromycin with chloramphenicol, fluoroquinolones and cephalosporins in culture-proven enteric fever were included. Data was extracted and methodological quality was assessed. Risk ratio (RR with 95% confidence intervals was estimated for the dichotomous outcomes and mean difference (MD with 95% confidence was estimated for continuous data. Primary outcomes studied were clinical failure (CF, microbiological failure, and relapse. Results: A total of seven RCTs involving 773 patients met with our inclusion criteria. In comparison to older fluoroquinolones, azithromycin is marginally better in reducing the chance of CF with RR 0.46 (95% CI 0.25-0.82, while in comparison to ceftriaxone, it significantly reduced the chance of relapse with RR 0.1 (95% CI 0.01- 0.76. There were no serious adverse events reported in any of the trials. Conclusion: Azithromycin can be recommended as a second-line drug in MDR typhoid fever, however, large trials involving pediatric age group patients are recommended to arrive at a definite conclusion.

  17. Multi-walled carbon nanotubes as alternative reversed-dispersive solid phase extraction materials in pesticide multi-residue analysis with QuEChERS method.

    Science.gov (United States)

    Zhao, Pengyue; Wang, Lei; Zhou, Li; Zhang, Fengzu; Kang, Shu; Pan, Canping

    2012-02-17

    A multi-residue method based on modified QuEChERS sample preparation with multi-walled carbon nanotubes (MWCNTs) as reversed-dispersive solid phase extraction (r-DSPE) material and gas chromatography-mass spectrometry determination by selected ion monitoring (GC/MS-SIM) mode was validated on 30 representative pesticides residues in vegetables and fruits. The acetonitrile-based QuEChERS (quick, easy, cheap, effective, rugged and safe) sample preparation technique was used to obtain the extracts, and the further cleanup was carried out by applying r-DSPE. It was found that the amount of MWCNTs influenced the cleanup performance and the recoveries. The optimal amount of 10mg MWCNTs was suitable for cleaning up all selected matrices, as a suitable alternative r-DSPE material to primary secondary amine (PSA). This method was validated on cabbage, spinach, grape and orange spiked at concentration levels of 0.02 and 0.2 mg/kg. The recoveries of 30 pesticides were in the range of 71-110%, with relative standard deviations (RSDs, n=5) lower than 15%. Matrix effects were observed by comparing the slope of matrix-matched standard calibration with that of solvent. Good linearity was achieved at the concentration levels of 0.02-0.5 mg/L. The limits of quantification (LOQs) and the limits of detection (LODs) for 30 pesticides ranged from 0.003 to 0.05 mg/kg and 0.001 to 0.02 mg/kg at the signal-to-noise ratio (S/N) of 10 and 3, respectively. The method was successfully applied to analysis real samples in Beijing. In conclusion, the modified QuEChERS method with MWCNTs cleanup step showed reliable method validation performances and good cleanup effects in this study. PMID:22227363

  18. Therapeutic efficacy of alternative primaquine regimens to standard treatment in preventing relapses by Plasmodium vivax: A systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Lina Marcela Zuluaga-Idarraga

    2015-12-01

    Full Text Available Objective:To compare efficacy and safety of primaquine regimens currently used to prevent relapses by P. vivax.Methods:A systematic review was carried out to identify clinical trials evaluating efficacy and safety to prevent malaria recurrences by P. vivax of primaquine regimen 0.5 mg / kg / day for 7 or 14 days compared to standard regimen of 0.25 mg/kg/day for 14 days. Efficacy of primaquine according to cumulative incidence of recurrences after 28 days was determined. The overall relative risk with fixed-effects meta-analysis was estimated.Results:For the regimen 0.5 mg/kg/day/7 days were identified 7 studies, which showed an incidence of recurrence between 0% and 20% with follow-up 60-210 days; only 4 studies comparing with the standard regimen 0.25 mg/kg/day/14 days and no difference in recurrences between both regimens (RR= 0.977, 95% CI= 0.670 to 1.423 were found. 3 clinical trials using regimen 0.5 mg/kg/day/14 days with an incidence of recurrences between 1.8% and 18.0% during 330-365 days were identified; only one study comparing with the standard regimen (RR= 0.846, 95% CI= 0.484 to 1.477. High risk of bias and differences in handling of included studies were found.Conclusion:Available evidence is insufficient to determine whether currently PQ regimens used as alternative rather than standard treatment have better efficacy and safety in preventing relapse of P. vivax. Clinical trials are required to guide changes in treatment regimen of malaria vivax.

  19. Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement*S⃞

    OpenAIRE

    Katschke, Kenneth J.; Stawicki, Scott; Yin, JianPing; Steffek, Micah; Xi, Hongkang; Sturgeon, Lizette; Hass, Philip E.; Loyet, Kelly M.; DeForge, Laura; Wu, Yan; van Lookeren Campagne, Menno; Wiesmann, Christian

    2009-01-01

    Amplification of the complement cascade through the alternative pathway can lead to excessive inflammation. Targeting C3b, a component central to the alternative pathway of complement, provides a powerful approach to inhibit complement-mediated immune responses and tissue injury. In the present study, phage display technology was employed to generate an antibody that selectively recognizes C3b but not the non-activated molecule C3. The crystal structure of C3b in compl...

  20. Lawrence Livermore National Laboratory Decontamination and Waste Treatment Facility: Documentation of impact analysis for design alternatives presented in the Draft Environmental Impact Statement

    International Nuclear Information System (INIS)

    Lawrence Livermore National Laboratory (LLNL) is proposing to construct and operate a new Decontamination and Waste Treatment Facility (DWTF). The proposed DWTF would replace the existing Hazardous Waste Management (HWM) facilities at LLNL. The US Department of Energy (DOE) is preparing a Draft Environmental Impact Statement (DEIS) to assess the environmental consequences of the proposed DWTF and its alternatives. This report presents the assumptions, methodologies, and analyses used to estimate the waste flows, air emissions, ambient air quality impacts, and public health risks that are presented in the DEIS. Two DWTF design alternatives (Level I and Level II) have been designated as reasonable design alternatives considering available technologies, environmental regulations, and current and future LLNL waste generation. Both design alternatives would include new, separate radioactive and nonradioactive liquid waste treatment systems, a solidification unit, a new decontamination facility, storage and treatment facilities for reactive materials, a radioactive waste storage area, receiving and classification areas, and a uranium burn pan. The Level I design alternative would include a controlled-air incinerator system, while the Level II design alternative would include a rotary kiln incinerator system. 43 refs., 4 figs., 24 tabs

  1. The influence of experience and training in a group of novice observers: A jackknife alternative free-response receiver operating characteristic analysis

    International Nuclear Information System (INIS)

    Purpose: The study evaluates the pre- and post-training lesion localisation ability of a group of novice observers. Parallels are drawn with the performance of inexperienced radiographers taking part in preliminary clinical evaluation (PCE) and ‘red-dot’ systems, operating within radiography practice. Materials and methods: Thirty-four novice observers searched 92 images for simulated lesions. Pre-training and post-training evaluations were completed following the free-response the receiver operating characteristic (FROC) method. Training consisted of observer performance methodology, the characteristics of the simulated lesions and information on lesion frequency. Jackknife alternative FROC (JAFROC) and highest rating inferred ROC analyses were performed to evaluate performance difference on lesion-based and case-based decisions. The significance level of the test was set at 0.05 to control the probability of Type I error. Results: JAFROC analysis (F(3,33) = 26.34, p < 0.0001) and highest-rating inferred ROC analysis (F(3,33) = 10.65, p = 0.0026) revealed a statistically significant difference in lesion detection performance. The JAFROC figure-of-merit was 0.563 (95% CI 0.512,0.614) pre-training and 0.677 (95% CI 0.639,0.715) post-training. Highest rating inferred ROC figure-of-merit was 0.728 (95% CI 0.701,0.755) pre-training and 0.772 (95% CI 0.750,0.793) post-training. Conclusions: This study has demonstrated that novice observer performance can improve significantly. This study design may have relevance in the assessment of inexperienced radiographers taking part in PCE or commenting scheme for trauma. - Highlights: • We assess novice observer performance pre- and post-training. • JAFROC and highest rating inferred ROC analyses were completed. • Novice observer performance improved from pre- to post-training. • Novice observers are better at making case-based rather than lesion-based decisions. • Parallels can be drawn between commenting

  2. Beyond the transect: An alternative microchemical imaging method for fine scale analysis of trace elements in fish otoliths during early life

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, Nicole [Elemental Bio-imaging Facility, University of Technology, Sydney, New South Wales (Australia); CCFS ARC Centre of Excellence, Department of Earth and Planetary Sciences, Macquarie University, Sydney (Australia); Fowler, Ashley M.; Parkinson, Kerryn [Fish Ecology Laboratory, School of the Environment, University of Technology, Sydney, New South Wales (Australia); Bishop, David P. [Elemental Bio-imaging Facility, University of Technology, Sydney, New South Wales (Australia); Ganio, Katherine [Florey Department of Neuroscience and Mental Health, University of Melbourne, Victoria (Australia); Doble, Philip A. [Elemental Bio-imaging Facility, University of Technology, Sydney, New South Wales (Australia); Booth, David J. [Fish Ecology Laboratory, School of the Environment, University of Technology, Sydney, New South Wales (Australia); Hare, Dominic J., E-mail: dominic.hare@uts.edu.au [Elemental Bio-imaging Facility, University of Technology, Sydney, New South Wales (Australia); Florey Department of Neuroscience and Mental Health, University of Melbourne, Victoria (Australia)

    2014-10-01

    scanning has no significant advantage over line scans. - Highlights: • Ba and Sr levels in otoliths from P. coelestis were imaged using LA-ICP-MS. • Longerich's calibration method was applied to quantitative otolith imaging. • An alternative to single line transects for microchemical analysis is presented.

  3. Beyond the transect: An alternative microchemical imaging method for fine scale analysis of trace elements in fish otoliths during early life

    International Nuclear Information System (INIS)

    has no significant advantage over line scans. - Highlights: • Ba and Sr levels in otoliths from P. coelestis were imaged using LA-ICP-MS. • Longerich's calibration method was applied to quantitative otolith imaging. • An alternative to single line transects for microchemical analysis is presented

  4. Complementary and Alternative Medicine

    Science.gov (United States)

    ... Help a Friend Who Cuts? Complementary and Alternative Medicine KidsHealth > For Teens > Complementary and Alternative Medicine Print ... replacement. continue How Is CAM Different From Conventional Medicine? Conventional medicine is based on scientific knowledge of ...

  5. Mutational analysis of the Trypanosoma vivax alternative oxidase: The E(X)6Y motif is conserved in both mitochondrial alternative oxidase and plastid terminal oxidase and is indispensable for enzyme activity

    International Nuclear Information System (INIS)

    Based on amino acid sequence similarity and the ability to catalyze the four-electron reduction of oxygen to water using a quinol substrate, mitochondrial alternative oxidase (AOX) and plastid terminal oxidase (PTOX) appear to be two closely related members of the membrane-bound diiron carboxylate group of proteins. In the current studies, we took advantage of the high activity of Trypanosoma vivax AOX (TvAOX) to examine the importance of the conserved Glu and the Tyr residues around the predicted third helix region of AOXs and PTOXs. We first compared the amino acid sequences of TvAOX with AOXs and PTOXs from various taxa and then performed alanine-scanning mutagenesis of TvAOX between amino acids Y199 and Y247. We found that the ubiquinol oxidase activity of TvAOX is completely lost in the E214A mutant, whereas mutants E215A and E216A retained more than 30% of the wild-type activity. Among the Tyr mutants, a complete loss of activity was also observed for the Y221A mutant, whereas the activities were equivalent to wild-type for the Y199A, Y212A, and Y247A mutants. Finally, residues Glu214 and Tyr221 were found to be strictly conserved among AOXs and PTOXs. Based on these findings, it appears that AOXs and PTOXs are a novel subclass of diiron carboxylate proteins that require the conserved motif E(X)6Y for enzyme activity

  6. Vehicle Design Evaluation Program (VDEP). A computer program for weight sizing, economic, performance and mission analysis of fuel-conservative aircraft, multibodied aircraft and large cargo aircraft using both JP and alternative fuels

    Science.gov (United States)

    Oman, B. H.

    1977-01-01

    The NASA Langley Research Center vehicle design evaluation program (VDEP-2) was expanded by (1) incorporating into the program a capability to conduct preliminary design studies on subsonic commercial transport type aircraft using both JP and such alternate fuels as hydrogen and methane;(2) incorporating an aircraft detailed mission and performance analysis capability; and (3) developing and incorporating an external loads analysis capability. The resulting computer program (VDEP-3) provides a preliminary design tool that enables the user to perform integrated sizing, structural analysis, and cost studies on subsonic commercial transport aircraft. Both versions of the VDEP-3 Program which are designated preliminary Analysis VDEP-3 and detailed Analysis VDEP utilize the same vehicle sizing subprogram which includes a detailed mission analysis capability, as well as a geometry and weight analysis for multibodied configurations.

  7. Support vector machine regression (LS-SVM)--an alternative to artificial neural networks (ANNs) for the analysis of quantum chemistry data?

    Science.gov (United States)

    Balabin, Roman M; Lomakina, Ekaterina I

    2011-06-28

    A multilayer feed-forward artificial neural network (MLP-ANN) with a single, hidden layer that contains a finite number of neurons can be regarded as a universal non-linear approximator. Today, the ANN method and linear regression (MLR) model are widely used for quantum chemistry (QC) data analysis (e.g., thermochemistry) to improve their accuracy (e.g., Gaussian G2-G4, B3LYP/B3-LYP, X1, or W1 theoretical methods). In this study, an alternative approach based on support vector machines (SVMs) is used, the least squares support vector machine (LS-SVM) regression. It has been applied to ab initio (first principle) and density functional theory (DFT) quantum chemistry data. So, QC + SVM methodology is an alternative to QC + ANN one. The task of the study was to estimate the Møller-Plesset (MPn) or DFT (B3LYP, BLYP, BMK) energies calculated with large basis sets (e.g., 6-311G(3df,3pd)) using smaller ones (6-311G, 6-311G*, 6-311G**) plus molecular descriptors. A molecular set (BRM-208) containing a total of 208 organic molecules was constructed and used for the LS-SVM training, cross-validation, and testing. MP2, MP3, MP4(DQ), MP4(SDQ), and MP4/MP4(SDTQ) ab initio methods were tested. Hartree-Fock (HF/SCF) results were also reported for comparison. Furthermore, constitutional (CD: total number of atoms and mole fractions of different atoms) and quantum-chemical (QD: HOMO-LUMO gap, dipole moment, average polarizability, and quadrupole moment) molecular descriptors were used for the building of the LS-SVM calibration model. Prediction accuracies (MADs) of 1.62 ± 0.51 and 0.85 ± 0.24 kcal mol(-1) (1 kcal mol(-1) = 4.184 kJ mol(-1)) were reached for SVM-based approximations of ab initio and DFT energies, respectively. The LS-SVM model was more accurate than the MLR model. A comparison with the artificial neural network approach shows that the accuracy of the LS-SVM method is similar to the accuracy of ANN. The extrapolation and interpolation results show that LS-SVM is

  8. Depleted uranium management alternatives

    International Nuclear Information System (INIS)

    This report evaluates two management alternatives for Department of Energy depleted uranium: continued storage as uranium hexafluoride, and conversion to uranium metal and fabrication to shielding for spent nuclear fuel containers. The results will be used to compare the costs with other alternatives, such as disposal. Cost estimates for the continued storage alternative are based on a life-cycle of 27 years through the year 2020. Cost estimates for the recycle alternative are based on existing conversion process costs and Capital costs for fabricating the containers. Additionally, the recycle alternative accounts for costs associated with intermediate product resale and secondary waste disposal for materials generated during the conversion process

  9. Review of bioinformatics data analysis in alternative splicing%可变剪接的生物信息数据分析综述

    Institute of Scientific and Technical Information of China (English)

    章天骄

    2012-01-01

    前体mRNA的可变剪接是扩大真核生物蛋白质组多样性的重要基因调控机制.可变剪接的错误调节可以引起多种人类疾病.由于高通量技术的发展,生物信息学成为可变剪接研究的主要手段.本文总结了可变剪接在生物信息学领域的研究方法,同时也分析并预测了可变剪接的发展方向.%Alternative pre - mRNA splicing is an important gene regulation mechanism for expanding proteomic diversity in higher eukaryotes. The misregulation of alternative splicing underlies many human diseases. With the development of high - throughput technology, bioinformatics becomes to the main method in study of alternative splicing. This article summarizes the bioinformatics methods in alternative splicing research, as well as analyzes and predicts the direction of alternative splicing.

  10. Evolutionary conservation of alternative splicing in chicken

    OpenAIRE

    Katyal, S.; Gao, Z.; Liu, R.-Z.; R Godbout

    2007-01-01

    Alternative splicing represents a source of great diversity for regulating protein expression and function. It has been estimated that one-third to two-thirds of mammalian genes are alternatively spliced. With the sequencing of the chicken genome and analysis of transcripts expressed in chicken tissues, we are now in a position to address evolutionary conservation of alternative splicing events in chicken and mammals. Here, we compare chicken and mammalian transcript sequences of 41 alternati...

  11. Potential of renewable and alternative energy sources

    OpenAIRE

    Konovalov, Vyacheslav Vasilievich; Pozharnitskaya, Olga Vyacheslavovna; Rostovshchikova, А.; Matveenko, Irina Alekseevna

    2015-01-01

    The article deals with application potential of clean alternative renewable energy sources. By means of system analysis the forecast for consumption of electrical energy in Tomsk Oblast as well as main energy sources of existing energy system have been studied up to 2018. Engineering potential of renewable and alternative energy sources is evaluated. Besides, ranking in the order of their efficiency descending is performed. It is concluded that Tomsk Oblast has high potential of alternative a...

  12. Nuclear energy: a sensible alternative

    International Nuclear Information System (INIS)

    This book presents in-depth articles on the main issues affecting the use and usefulness of nuclear energy for peaceful domestic purposes. Topics considered include energy futures (a world study), energy demand-energy supplies, an energy-deficient society, energy shortages, the economics of light water reactors (LWRs), fast breeder reactor economics, international cooperation in the nuclear field, nuclear recycling (costs, savings, safeguards), alternative fuels, alternative fuel cycles, alternative reactors, the nuclear weapons proliferation issue, paths to a world with more reliable nuclear safeguards, the homemade bomb issue, LWR risk assessment, accident analysis and risk assessment, the waste disposal risk, radon problems, health effects of low-level radiation, routine releases of radioactivity, plutonium toxicity, and the Price-Anderson Act

  13. Alternative energies. Updates on progress

    International Nuclear Information System (INIS)

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  14. Alternative energies. Updates on progress

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, German (ed.) [CIRCE - Centre of Research for Energy Resources and Consumption, Zaragoza (Spain)

    2013-07-01

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  15. A Meta-Analysis of Single Case Research Studies on Aided Augmentative and Alternative Communication Systems with Individuals with Autism Spectrum Disorders

    Science.gov (United States)

    Ganz, Jennifer B.; Earles-Vollrath, Theresa L.; Heath, Amy K.; Parker, Richard I.; Rispoli, Mandy J.; Duran, Jaime B.

    2012-01-01

    Many individuals with autism cannot speak or cannot speak intelligibly. A variety of aided augmentative and alternative communication (AAC) approaches have been investigated. Most of the research on these approaches has been single-case research, with small numbers of participants. The purpose of this investigation was to meta-analyze the single…

  16. Analysis of nitrogen injection as alternative fluid to steam in heavy oil reservoir; Analise da injecao de nitrogenio como fluido alternativo ao vapor em reservatorio de oleo pesado

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Marcos Allyson Felipe; Galvao, Edney Rafael Viana Pinheiro; Barillas, Jennys Lourdes; Mata, Wilson da; Dutra Junior, Tarcilio Viana [Universidade Federal do Rio Grande do Norte (UFRN), RN (Brazil)

    2012-07-01

    Many of hydrocarbon reserves existing in the world are formed by heavy oils (deg API between 10 and 20). Moreover, several heavy oil fields are mature and, thus, offer great challenges for oil industry. Among the thermal methods used to recover these resources, steam flooding has been the main economically viable alternative. Latent heat carried by steam heats the reservoir, reducing oil viscosity and facilitating the production. This method has many variations and has been studied both theoretically and experimentally (in pilot projects and in full field applications). In order to increase oil recovery and reduce steam injection costs, the injection of alternative fluid has been used on three main ways: alternately, co-injected with steam and after steam injection interruption. The main objective of these injection systems is to reduce the amount of heat supplied to the reservoir, using cheaper fluids and maintaining the same oil production levels. In this paper, the use of N{sub 2} as an alternative fluid to the steam was investigated. The analyzed parameters were oil recoveries and net cumulative oil productions. The reservoir simulation model corresponds to an oil reservoir of 100 m x 100 m x 28 m size, on a Cartesian coordinates system (x, y and z directions). It is a semi synthetic model with some reservoir data similar to those found in Potiguar Basin, Brazil. All studied cases were done using the simulator STARS from CMG (Computer Modelling Group, version 2009.10). It was found that N{sub 2} injection after steam injection interruption achieved the highest net cumulative oil compared to others injection system. Moreover, it was observed that N2 as alternative fluid to steam did not present increase on oil recovery. (author)

  17. Polyphase alternating codes

    CERN Document Server

    Markkanen, Markku

    2007-01-01

    This work introduces a method for constructing polyphase alternating codes in which the length of a code transmission cycle can be $p^m$ or $p-1$, where $p$ is a prime number and $m$ is a positive integer. The relevant properties leading to the construction alternating codes and the algorithm for generating alternating codes is described. Examples of all practical and some not that practical polyphase code lengths are given.

  18. Alternative Solar Indices

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, L.J.

    1980-07-01

    Possible alternative Solar Indices which could either be a perturbation from the currently defined Solar Index or possible indices based on current technologies for other media markets are discussed. An overview is given of the current project, including the logic that was utilized in defining its current structure and then alternative indices and definitions are presented and finally, recommendations are made for adopting alternative indices.

  19. On an Alternative Cosmology

    OpenAIRE

    Vankov, A.

    1998-01-01

    The suggested alternative cosmology is based on the idea of barion symmetric universe, in which our home universe is a representative of multitude of typical matter and antimatter universes. This alternative concept gives a physically reasonable explanation of all major problems of the Standard Cosmological Model. Classification Code MSC: Cosmology 524.8 Key words: standard cosmological model, alternative cosmology, barionic symmetry, typical universe, quasars, cosmic rays.

  20. Complex Alternative Splicing

    OpenAIRE

    Park, Jung Woo; Graveley, Brenton R.

    2007-01-01

    Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes that use alternative splicing to generate hundreds, thousands, and even tens of thousands of isoforms. Collectively such genes are considered to undergo complex alternative splicing. The best example is the Drosophila Down syndrome cell adhesion molecule (Dscam) gene, which can generate 38,016 is...

  1. Alternate-fuel reactor studies

    International Nuclear Information System (INIS)

    A number of studies related to improvements and/or greater understanding of alternate-fueled reactors is presented. These studies cover the areas of non-Maxwellian distributions, materials and lifetime analysis, a 3He-breeding blanket, tritium-rich startup effects, high field magnet support, and reactor operation spanning the range from full D-T operation to operation with no tritium breeding

  2. FMDP reactor alternative summary report: Volume 4, Evolutionary LWR alternative

    International Nuclear Information System (INIS)

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] have become surplus to national defense needs both in the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES ampersand H) consequences if surplus fissile materials are not properly managed. The purpose of this report is to provide schedule, cost, and technical information that will be used to support the Record of Process (ROD). Following the screening process, DOE/MD via its national laboratories initiated a more detailed analysis activity to further evaluate each of the ten plutonium disposition alternatives that survived the screening process. Three ''Alternative Teams,'' chartered by DOE and comprised of technical experts from across the DOE national laboratory complex, conducted these analyses. One team was chartered for each of the major disposition classes (borehole, immobilization, and reactors). During the last year and a half, the Fissile Materials Disposition Program (FMDP) Reactor Alternative Team (RxAT) has conducted extensive analyses of the cost, schedule, technical maturity, S ampersand S, and other characteristics of reactor-based plutonium disposition. The results of the RxAT's analyses of the existing LWR, CANDU, and partially complete LWR alternatives are documented in Volumes 1-3 of this report. This document (Volume 4) summarizes the results of these analyses for the ELWR-based plutonium disposition option

  3. Economic analysis of alternative bison and elk management practices on the National Elk Refuge and Grand Teton National Park: A comparison of visitor and household responses

    Science.gov (United States)

    Loomis, John B.; Caughlan, Lynne

    2004-01-01

    The U.S. Fish and Wildlife Service (FWS) and the National Park Service (NPS) are preparing a management plan for bison and elk inhabiting the National Elk Refuge (NER) and Grand Teton National Park (GTNP). These animals are part of the bison and elk herds in Jackson Hole, one of the largest concentrations of freeranging bison and elk in the world. A range of alternatives for managing the bison and elk herds in the project area will be developed in an Environmental Impact Statement. The EIS will likely include such issues as habitat management, disease management, winter-feeding and hunting programs related to the NER and GTNP. The purposes of this study are to determine how the current management and EIS alternatives for bison and elk inhabiting the NER and GTNP would change: Visitor use

  4. Alternative Devices for Taking Insulin

    Science.gov (United States)

    ... KB). Alternate Language URL Alternative Devices for Taking Insulin Page Content On this page: What alternative devices ... the skin. [ Top ] What alternative devices for taking insulin are available? Insulin pens provide a convenient, easy- ...

  5. Towards HumanRobot Teams: Model-Based Analysis of Human Decision Making in Two-Alternative Choice Tasks With Social Feedback

    OpenAIRE

    Stewart, Andrew; Cao, Ming; Nedic, Andrea; Tomlin, Damon; Leonard, Naomi Ehrich

    2012-01-01

    With a principled methodology for systematic design of human–robot decision-making teams as a motivating goal, we seek an analytic, model-based description of the influence of team and network design parameters on decision-making performance. Given that there are few reliably predictive models of human decision making, we consider the relatively well-understood two-alternative choice tasks from cognitive psychology, where individuals make sequential decisions with limited information, and we ...

  6. An Empirical Analysis of the Impact of Federal Budget Deficits on Long-term Nominal Interest Rate Yields, 1973.2-1995.4, Using Alternative Expected Inflation Measures

    OpenAIRE

    Cebula, Richard

    1997-01-01

    Using two alternative measures of expected inflation, this study investigates the impact of federal budget deficits on nominal long-term interest rate yields for the 1973.2-1995.4 period. Based on an open­ economy loanable funds framework, four instrumental variable esti­mates in first differences are provided. In all cases, the budget deficit is found to elevate the nominal long-term interest rate.

  7. Comparative analysis of serine/arginine-rich proteins across 27 eukaryotes: insights into sub-family classification and extent of alternative splicing.

    Directory of Open Access Journals (Sweden)

    Dale N Richardson

    Full Text Available Alternative splicing (AS of pre-mRNA is a fundamental molecular process that generates diversity in the transcriptome and proteome of eukaryotic organisms. SR proteins, a family of splicing regulators with one or two RNA recognition motifs (RRMs at the N-terminus and an arg/ser-rich domain at the C-terminus, function in both constitutive and alternative splicing. We identified SR proteins in 27 eukaryotic species, which include plants, animals, fungi and "basal" eukaryotes that lie outside of these lineages. Using RNA recognition motifs (RRMs as a phylogenetic marker, we classified 272 SR genes into robust sub-families. The SR gene family can be split into five major groupings, which can be further separated into 11 distinct sub-families. Most flowering plants have double or nearly double the number of SR genes found in vertebrates. The majority of plant SR genes are under purifying selection. Moreover, in all paralogous SR genes in Arabidopsis, rice, soybean and maize, one of the two paralogs is preferentially expressed throughout plant development. We also assessed the extent of AS in SR genes based on a splice graph approach (http://combi.cs.colostate.edu/as/gmap_SRgenes. AS of SR genes is a widespread phenomenon throughout multiple lineages, with alternative 3' or 5' splicing events being the most prominent type of event. However, plant-enriched sub-families have 57%-88% of their SR genes experiencing some type of AS compared to the 40%-54% seen in other sub-families. The SR gene family is pervasive throughout multiple eukaryotic lineages, conserved in sequence and domain organization, but differs in gene number across lineages with an abundance of SR genes in flowering plants. The higher number of alternatively spliced SR genes in plants emphasizes the importance of AS in generating splice variants in these organisms.

  8. Analysis of the Isoprenoid Biosynthesis Pathways in Listeria monocytogenes Reveals a Role for the Alternative 2-C-Methyl-d-Erythritol 4-Phosphate Pathway in Murine Infection▿

    OpenAIRE

    Begley, Máire; Bron, Peter A; Heuston, Sinead; Casey, Pat G.; Englert, Nadine; Wiesner, Jochen; Jomaa, Hassan; Gahan, Cormac G. M.; Hill, Colin

    2008-01-01

    Most bacteria synthesize isoprenoids through one of two essential pathways which provide the basic building block, isopentyl diphosphate (IPP): either the classical mevalonate pathway or the alternative non-mevalonate 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway. However, postgenomic analyses of the Listeria monocytogenes genome revealed that this pathogen possesses the genetic capacity to produce the complete set of enzymes involved in both pathways. The nonpathogenic species Listeria i...

  9. Mixed-Mode Fracture and Fatigue Analysis of Cracked 3D Complex Structures using a 3D SGBEM-FEM Alternating Method

    Science.gov (United States)

    Bhavanam, Sharada

    The aim of this thesis is to numerically evaluate the mixed-mode Stress Intensity Factors (SIFs) of complex 3D structural geometries with arbitrary 3D cracks using the Symmetric Galerkin Boundary Element Method-Finite Element Method (SGBEM-FEM) Alternating Method. Various structural geometries with different loading scenarios and crack configurations were examined in this thesis to understand the behavior and trends of the mixed-mode SIFs as well as the fatigue life for these complex structural geometries. Although some 3D structures have empirical and numerical solutions that are readily available in the open literature, some do not; therefore this thesis presents the results of fracture and fatigue analyses of these 3D complex structures using the SGBEM-FEM Alternating Method to serve as reference for future studies. Furthermore, there are advantages of using the SGBEM-FEM Alternating Method compared to traditional FEM methods. For example, the fatigue-crack-growth and fatigue life can be better estimated for a structure because different fatigue models (i.e. Walker, Paris, and NASGRO) can be used within the same framework of the SGBEM-FEM Alternating Method. The FEM (un-cracked structure)/BEM(crack model) meshes are modeled independently, which speeds up the computation process and reduces the cost of human labor. A simple coarse mesh can be used for all fracture and fatigue analyses of complex structures. In this thesis, simple coarse meshes were used for 3D complex structures, which were below 5000 elements as compared to traditional FEM, which require meshes where the elements range on the order of ˜250,000 to ˜106 and sometimes even more than that.

  10. An analysis of Alternative Dispute Resolution (ADR) as it applies to contract dispute settlement and its use by the Defense Industry

    OpenAIRE

    Begin, Marc A.

    1999-01-01

    The objective of this research is to assess the extent to which defense contractors employ the use of Alternative Dispute Resolution (ADR) in their contract dispute settlement processes. A questionnaire was utilized to gather information from thirty defense contractors. The thesis provides a legislative background for ADR, and briefly discusses various techniques of the ADR process. Additionally, data collected from industry are presented and discussed. The study identified mediation and nego...

  11. Brandmodstandsbidrag for alternative isoleringsmaterialer

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2001-01-01

    Resume af rapport om alternative isoleringsmaterialers brandmodstandsbidrag, udarbejdet af Dansk Brandteknisk Institut under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"......Resume af rapport om alternative isoleringsmaterialers brandmodstandsbidrag, udarbejdet af Dansk Brandteknisk Institut under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"...

  12. Anvendelse af alternative isoleringsmaterialer

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2003-01-01

    Resume af By og Byg Anvisning 207 om anvendelse af alternative isoleringsmaterialer, udarbejdet af Statens Byggeforskningsinstitut under udviklingsprogrammet "Miljø- og arbejdsmiljøvenlig isolering"......Resume af By og Byg Anvisning 207 om anvendelse af alternative isoleringsmaterialer, udarbejdet af Statens Byggeforskningsinstitut under udviklingsprogrammet "Miljø- og arbejdsmiljøvenlig isolering"...

  13. Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene

    DEFF Research Database (Denmark)

    Armano, MT; Ferriani, VP; Florido, MP;

    2008-01-01

    ' fibroblasts when analyzed by confocal microscopy. We show that all four siblings are homozygous for a mutation at position 938 in exon 6 of the C1s cDNA that creates a premature stop codon. Our investigations led us to reveal the presence of previously uncharacterized splice variants of C1s mRNA transcripts...... in normal human cells. These variants are derived from the skipping of exon 3 and from the use of an alternative 3' splice site within intron 1 which increases the size of exon 2 by 87 nucleotides....

  14. Alternative loop rings

    CERN Document Server

    Goodaire, EG; Polcino Milies, C

    1996-01-01

    For the past ten years, alternative loop rings have intrigued mathematicians from a wide cross-section of modern algebra. As a consequence, the theory of alternative loop rings has grown tremendously. One of the main developments is the complete characterization of loops which have an alternative but not associative, loop ring. Furthermore, there is a very close relationship between the algebraic structures of loop rings and of group rings over 2-groups. Another major topic of research is the study of the unit loop of the integral loop ring. Here the interaction between loop rings and group ri

  15. Krypton control alternatives

    International Nuclear Information System (INIS)

    A reprocessing plant for 350 metric tons per year LWR spent fuel cooled for at least 7 years is planned in the FRG. A routine Kr-85 retention for radiation protection reasons is not demanded by the German reactor safety and radiation management technology for larger plants in the future. The licensing authorities also do not require a routine Kr-85 retention at the plant site. Technical and safety characteristics of various Kr-85 removal processes are described and compared, including the precleaning steps in an integrated dissolver off-gas system. The interactions with subsequent conditioning and storage of Kr and with process modifications in the plant headend are also taken into account. A commercial use of the inactive Xe and part of the Kr-85 may have an influence on a cost-benefit analysis and the selection of a removal process. Two alternative processes are being developed on an engineering scale. A cryogenic distillation process using an O2-free off-gas is under investigation on a pilot plant scale since 1976. A selective absorption process using freon-12 at low temperatures and at atmospheric pressure has been investigated at the laboratory scale since 1980. Test operation on an engineering scale started late in 1983. Essential results and operating experiences with both facilities are summarized. Technical as well as safety aspects are in favor of the selective absorption process. A final decision on what process will be used in the future shall be made as soon as comparable technical experiences from both processes are available

  16. Seal design alternatives study

    International Nuclear Information System (INIS)

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information

  17. Seal design alternatives study

    Energy Technology Data Exchange (ETDEWEB)

    Van Sambeek, L.L. [RE/SPEC Inc., Rapid City, SD (US); Luo, D.D.; Lin, M.S.; Ostrowski, W.; Oyenuga, D. [Parsons Brinckerhoff Quade & Douglas, Inc., San Francisco, CA (US)

    1993-06-01

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information.

  18. An alternative currency

    OpenAIRE

    Frendo, Mario; Duca, Edward

    2013-01-01

    Malta- a tiny island, a minute social reality, a precursory canovaccio of European unification- has a unique asset it ought to be prouder of: culture. http://www.um.edu.mt/think/an-alternative-currency/

  19. Alternatives to Nursing Homes

    Science.gov (United States)

    ... this website may not be available. Alternatives to nursing homes Before you make any decisions about long ... live and what help you may need. A nursing home may not be your only choice. Discharge ...

  20. Vaginal dryness alternative treatments

    Science.gov (United States)

    ... a day. Soybeans contain plant-based substances called isoflavones. These substances have an effect on the body ... soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study. Menopause . 2008;15(1):51-58. ...

  1. Alternative fuel information sources

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    This short document contains a list of more than 200 US sources of information (Name, address, phone number, and sometimes contact) related to the use of alternative fuels in automobiles and trucks. Electric-powered cars are also included.

  2. The alternative library

    OpenAIRE

    Collinson, Timothy; A. Williams

    2004-01-01

    Much time and effort has been devoted to designing and developing library Web sites that are easy to navigate by both new students and experienced researchers. In a review of the Southampton Institute Library it was decided that in addition to updating the existing homepage an alternative would be offered. Drawing on theory relating to user interface design, learning styles and creative thinking, an Alternative Library navigation system was added to the more traditional library homepage. The ...

  3. Alternative fuel cycles

    International Nuclear Information System (INIS)

    Uranium resource utilization and economic considerations provide incentives to study alternative fuel cycles as future options to the PHWR natural uranium cycle. Preliminary studies to define the most favourable alternatives and their possible introduction dates are discussed. The important and uncertain components which influence option selection are reviewed, including nuclear capacity growth, uranium availability and demand, economic potential, and required technological developments. Finally, a summary of Ontario Hydro's program to further assess cycle selection and define development needs is given. (auth)

  4. Ultimacy and alternative possibilities

    OpenAIRE

    Fischer, John Martin

    2009-01-01

    I explore a key feature of Robert Kane’s libertarianism (about which I have been puzzled for some time). Kane claims that we should separate issues of alternative possibilities from issues of ultimacy, but he further argues that they are connected in a certain way. I call into question this connection, and I continue to argue for a strict separation of considerations pertaining to alternative possibilities and “actual-sequence” considerations.

  5. Des divisions aux alternances

    Directory of Open Access Journals (Sweden)

    Eric Clemens

    2012-12-01

    Full Text Available - From the divisions to the alternations - Society, action and common good give sense to democracy. Society is in fact a set of unmitigated divisions (horizontal and vertical, material and symbolic. Democratic action, since the discourse’s conflicts, doesn’t change the human beings, but things between they, in the alternation of power’s institutions for our only good in common: the body. With this aim, the Basic Income Earth Network is necessary.

  6. Analysis of the Madaras Rotor Power Plant: an alternate method for extracting large amounts of power from the wind. Volume 2. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    Whitford, D.H.; Minardi, J.E.; West, B.S.; Dominic, R.J.

    1978-06-01

    The purpose of the program was to analyze and up-date the design of the Madaras Rotor Power Plant concept that had been developed in the 1930's to determine the technical and economic feasibility of this system to be competitive with conventional horizontal axis wind turbines. A four-task program consisting of a series of wind tunnel tests, an electro-mechanical analysis, a performance analysis, and a cost analysis was conducted.

  7. FMDP Reactor Alternative Summary Report: Volume 2 - CANDU heavy water reactor alternative

    International Nuclear Information System (INIS)

    The Department of Energy Office of Fissile Materials Disposition (DOE/MD) initiated a detailed analysis activity to evaluate each of ten plutonium disposition alternatives that survived an initial screening process. This document, Volume 2 of a four volume report, summarizes the results of these analyses for the CANDU reactor based plutonium disposition alternative

  8. FMDP Reactor Alternative Summary Report: Volume 3 - partially complete LWR alternative

    International Nuclear Information System (INIS)

    The Department of Energy Office of Fissile Materials Disposition (DOE/MD) initiated a detailed analysis activity to evaluate each of ten plutonium disposition alternatives that survived an initial screening process. This document, Volume 3 of a four volume report summarizes the results of these analyses for the partially complete LWR (PCLWR) reactor based plutonium disposition alternative

  9. A socio-anthropological analysis of deficits of transition process in Serbia 2005-2006 and possibilities for elaborating alternative projects

    Directory of Open Access Journals (Sweden)

    Golubović Zagorka

    2006-01-01

    Full Text Available The paper is an outline of the author’s research project to be undertaken in 2006. It is focused on the process of transition from authoritarian to democratic order in Serbia after 2000. Starting from the findings of previous studies of transition, in Serbia and in other post socialist countries, the research will adopt a socio-anthropological approach and deal with the following topics: the model of transition being applied in Serbia preconditions for democratic transformation; a balance sheet of positive achievements accomplished and, on the other hand, "lost chances"; socio economic, political and cultural obstacles to articulating a coherent strategy of democratic development; psychological and anthropological aspects of current processes; alternative paths of democratic development feasible within given conditions. A central question the research will aim at resolving is why the current situation in Serbia is often described as suffering from a "democratic deficit".

  10. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    Energy Technology Data Exchange (ETDEWEB)

    Greene, S.R.; Bevard, B.B. [and others

    1996-10-07

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES&H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives.

  11. FMDP reactor alternative summary report. Volume 1 - existing LWR alternative

    International Nuclear Information System (INIS)

    Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES ampersand H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives

  12. Potential of renewable and alternative energy sources

    Science.gov (United States)

    Konovalov, V.; Pogharnitskaya, O.; Rostovshchikova, A.; Matveenko, I.

    2015-11-01

    The article deals with application potential of clean alternative renewable energy sources. By means of system analysis the forecast for consumption of electrical energy in Tomsk Oblast as well as main energy sources of existing energy system have been studied up to 2018. Engineering potential of renewable and alternative energy sources is evaluated. Besides, ranking in the order of their efficiency descending is performed. It is concluded that Tomsk Oblast has high potential of alternative and renewable energy sources, among which the most promising development perspective is implementation of gasification stations to save fuel consumed by diesel power stations as well as building wind-power plants.

  13. Innovative and Alternative Technology Assessment Manual

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-01

    This four chapter, six appendix manual presents the procedures and methodology as well as the baseline costs and energy information necessary for the analysis and evaluation of innovative and alternative technology applications submitted for federal grant assistance under the innovative and alternative technology provisions of the Clean Water Act of 1977. The manual clarifies and interprets the intent of Congress and the Environmental Protection Agency in carrying out the mandates of the innovative and alternative provisions of the Clean Water Act of 1977. [DJE 2005

  14. Alternative Instructional Strategies in an IS Curriculum

    Science.gov (United States)

    Parker, Kevin R.; LeRouge, Cynthia; Trimmer, Ken

    2005-01-01

    Systems Analysis and Design is a core component of an education in information systems. To appeal to a wider range of constituents and facilitate the learning process, the content of a traditional Systems Analysis and Design course has been supplemented with an alternative modeling approach. This paper presents an instructional design that…

  15. Alternative Educational Futures for a Knowledge Society

    Science.gov (United States)

    Young, Michael

    2010-01-01

    This article offers a critical analysis of recent trends in educational policy with particular reference to their assumptions about the knowledge society. It examines the implications of the analysis for the issue of elitism and the promotion of greater educational equality. The article concludes by offering an alternative approach to educational…

  16. Membership Policy Alternatives for Marketing Cooperatives

    OpenAIRE

    Sporleder, Thomas L.

    1988-01-01

    Marketing cooperatives operating pools that consistently obtain member returns in excess of cash market prices must accommodate new members. In some cooperatives, the membership policy is based only on the capital plan. This article presents alternative membership policies for the acquisition and transfer of rights to original members. Specific policy alternatives for each component are defined and examined. The analysis suggests that strategic planning in some cooperatives should involve exp...

  17. The future role of alternative powertrains and fuels in the German transport sector. A model based scenario analysis with respect to technical, economic and environmental aspects with a focus on road transport

    International Nuclear Information System (INIS)

    The transport sector is facing the challenges of satisfying the ever increasing transport demand on the one hand and achieving greenhouse gas (GHG) emission reduction targets without compromising economic development on the other hand. There are various alternative fuels and powertrains which might play a role in the future of the German transport sector. Amongst these options, biofuels are considered to help lower GHG emissions. However, they are severely criticized to create an additional strain for the energy system and particularly for the transport sector with land area requirement for energy crop production, which may imply a competition with food production. This study aims to assess the future role of alternative fuels and powertrains in the German transport sector in terms of their costs, efficiencies, GHG emissions and land area requirement for energy crops. To fulfill this aim, a techno-economic analysis of all relevant fuels and powertrain options was performed and a model based approach was employed. The utilized model belongs to the TIMES (The Integrated MARKAL EFOM System) family and is a bottom-up linear cost optimization energy system model. A scenario analysis was employed in order to assess the effect of different technological, economic, environmental and political conditions on the overall system. The results of the scenario analysis indicated that the transport system will still be dominated by conventional powertrains in 2030. Alternative powertrains are projected to play only a secondary role until 2030. It is not expected that fuel cell or battery electric passenger cars will be introduced into the market until 2030 in Germany. Nevertheless, hybrid electric powertrains have to be used in the German passenger car sector under ambitious GHG emission reduction targets and high oil prices. The introduction of alternative powertrains (such as hybrid electric and fuel cell powertrain) is much more likely in the bus sector (especially for public

  18. Catalysis for alternative energy generation

    CERN Document Server

    2012-01-01

    Summarizes recent problems in using catalysts in alternative energy generation and proposes novel solutions  Reconsiders the role of catalysis in alternative energy generation  Contributors include catalysis and alternative energy experts from across the globe

  19. Alternatives for pseudofinite groups

    CERN Document Server

    Houcine, Abderezak Ould

    2012-01-01

    The famous Tits' alternative states that a linear group either contains a nonabelian free group or is soluble-by-(locally finite). We study in this paper similar alternatives in pseudofinite groups. We show for instance that an $\\aleph_{0}$-saturated pseudofinite group either contains a subsemigroup of rank $2$ or is nilpotent-by-(uniformly locally finite). We call a class of finite groups $G$ weakly of bounded rank if the radical $rad(G)$ has a bounded Pr\\"ufer rank and the index of the sockel of $G/rad(G)$ is bounded. We show that an $\\aleph_{0}$-saturated pseudo-(finite weakly of bounded rank) group either contains a nonabelian free group or is nilpotent-by-abelian-by-(uniformly locally finite). We also obtain some relations between this kind of alternatives and amenability.

  20. Bouncing alternatives to inflation

    CERN Document Server

    Lilley, Marc

    2015-01-01

    Although the inflationary paradigm is the most widely accepted explanation for the current cosmological observations, it does not necessarily correspond to what actually happened in the early stages of our Universe. To decide on this issue, two paths can be followed: first, all the possible predictions it makes must be derived thoroughly and compared with available data, and second, all imaginable alternatives must be ruled out. Leaving the first task to all other contributors of this volume, we concentrate here on the second option, focusing on the bouncing alternatives and their consequences.