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Sample records for alternative-splicing-based bicistronic vectors

  1. Alternative-splicing-based bicistronic vectors for ratio-controlled protein expression and application to recombinant antibody production.

    OpenAIRE

    Fallot, Stéphanie; Ben Naya, Raouia; Hieblot, Corinne; Mondon, Philippe; Lacazette, Eric; Bouayadi, Khalil; Kharrat, Abdelhakim; Touriol, Christian; Prats, Hervé

    2009-01-01

    In the last decade polycistronic vectors have become essential tools for both basic science and gene therapy applications. In order to co-express heterologous polypeptides, different systems have been developed from Internal Ribosome Entry Site (IRES) based vectors to the use of the 2A peptide. Unfortunately, these methods are not fully suitable for the efficient and reproducible modulation of the ratio between the proteins of interest. Here we describe a novel bicistronic vector type based o...

  2. Long term expression of bicistronic vector driven by the FGF-1 IRES in mouse muscle

    Directory of Open Access Journals (Sweden)

    Van den Berghe Loïc

    2007-10-01

    Full Text Available Abstract Background Electrotransfer of plasmid DNA into skeletal muscle is a promising strategy for the delivery of therapeutic molecules targeting various muscular diseases, cancer and lower-limb ischemia. Internal Ribosome Entry Sites (IRESs allow co-expression of proteins of interest from a single transcriptional unit. IRESs are RNA elements that have been found in viral RNAs as well as a variety of cellular mRNAs with long 5' untranslated regions. While the encephalomyocarditis virus (EMCV IRES is often used in expression vectors, we have shown that the FGF-1 IRES is equally active to drive short term transgene expression in mouse muscle. To compare the ability of the FGF-1 IRES to drive long term expression against the EMCV and FGF-2 IRESs, we performed analyses of expression kinetics using bicistronic vectors that express the bioluminescent renilla and firefly luciferase reporter genes. Long term expression of bicistronic vectors was also compared to that of monocistronic vectors. Bioluminescence was quantified ex vivo using a luminometer and in vivo using a CCD camera that monitors luminescence within live animals. Results Our data demonstrate that the efficiency of the FGF-1 IRES is comparable to that of the EMCV IRES for long term expression of bicistronic transgenes in mouse muscle, whereas the FGF-2 IRES has a very poor activity. Interestingly, we show that despite the global decrease of vector expression over time, the ratio of firefly to renilla luciferase remains stable with bicistronic vectors containing the FGF-1 or FGF-2 IRES and is slightly affected with the EMCV IRES, whereas it is clearly unstable for mixed monocistronic vectors. In addition, long term expression more drastically decreases with monocistronic vectors, and is different for single or mixed vector injection. Conclusion These data validate the use of bicistronic vectors rather than mixed monocistronic vectors for long term expression, and support the use of the

  3. High-titer bicistronic retroviral vectors employing foot-and-mouth disease virus internal ribosome entry site.

    OpenAIRE

    Ramesh, N; Kim, S. T.; Wei, M. Q.; Khalighi, M; Osborne, W R

    1996-01-01

    Bicistronic retroviral vectors were constructed containing the foot-and-mouth disease virus (FMDV) internal ribosome entry site (IRES) followed by the coding region of beta-galactosidase (beta-gal) or therapeutic genes, with the selectable neomycin phosphotransferase gene under the control of the viral long terminal repeat (LTR) promoter. LNFX, a vector with a multiple cloning site 3' to foot-and-mouth disease virus IRES, was used to construct vectors encoding rat erythropoietin (EP), rat gra...

  4. Construction and characterization in vitro of a bicistronic retroviral vector coding endostatin and interleukin-2 for use in gene therapy

    International Nuclear Information System (INIS)

    Gene therapy has been used in preclinical studies and clinical trials in order to alleviate or cure a disease. Retroviral vectors are a tool for gene transfer is widely used. Bicistronic vectors are an attractive alternative for treatment of complex diseases. A variety of options exists to simultaneously express two genes in genetically modified cells. The most common approach relies on bicistronic vectors in which the genes are linked to each other by an internal ribosome entry site allowing co-translational expression of both cistrons. Endostatin, the C-terminal fragment of collagen XVIII, is a potent angiogenesis inhibitor. At present, ES has been widely used in anti-angiogenic in a variety of experimental tumor models, and clinical trials to test it as an anti-tumor agent are already under way. Immunotherapy has been used as adjuvant treatment for tumors and has been used in several preclinical studies and clinical trials. The objective of this project was to construct and characterize 'in vitro' an IRES-based bicistronic retroviral vector encoding endostatin and interleukin-2. The construction of the vector was performed in three stages, the final construction was analyzed by restriction analysis and sequencing. Packaging cells were prepared. The endostatin and interleukin-2 levels were determined by Dot blot. Monocistronic and bicistronic mRNA expression were analyzed by real time RT-PCR. Bicistronic vector showed high levels of virus trites, ranging from 4.20x105 to 1.53x106UFC/ml. Secreted levels of endostatin and interleukin-2 ranged from 1.08 to 2.08μg/106cells.24h and 0.66 - 0.89μg/106cells.24h, respectively. The mRNA expression of ES in the NIH3T3 clone pLend-IRES-IL2SN was 2 times higher than the level presented by the NIH3T3 clone pLendSN. The endostatin promoted inhibition (40%) of endothelial cell proliferation. Interleukin-2 promoted a proliferation of 10.6% lymphocytes CD4 and 8.9% of CD8. We conclude that the IRES bicistronic vector provides a

  5. Bicistronic retroviral vectors for combining myeloprotection with cell-surface marking.

    Science.gov (United States)

    Hildinger, M; Schilz, A; Eckert, H G; Bohn, W; Fehse, B; Zander, A; Ostertag, W; Baum, C

    1999-07-01

    We have developed a retroviral vector coexpressing the multidrug-resistance 1 (MDR1) cDNA for inducing cancer drug resistance and the truncated version of the low-affinity nerve growth factor receptor (DeltaLNGFR) for cell-surface marking of transduced cells. The vector is based on the FMEV backbone which mediates high levels of gene expression in hematopoietic cells. To achieve optimal expression levels of both cDNAs, untranslated regions from MDR1 and DeltaLNGFR were removed and three different connections were tested: retroviral splice signals, an internal ribosomal entry site (IRES) from encephalomyocarditis virus, and an internal promoter from the chicken beta-actin gene. As determined by two-color flow cytometry, the best correlation of the expression of both cDNAs was obtained using the vector SF1mSdelta which utilized retroviral splice signals for co-expression. Simultaneous expression of both cDNAs at the single cell level was also shown by confocal laser microscopy. Lymphoid and hematopoietic progenitor cells, including primary human CD34+ cells, transduced with SF1mSdelta acquired dominant multidrug resistance. Transduced primary CD34+ cells could be enriched in vitro based on expression of DeltaLNGFR, avoiding exposure to cytostatic agents. Thus, monitoring the selection of chemotherapy-resistant cells and analyzing their biological properties may be alleviated, both in vitro and in vivo. PMID:10455430

  6. Construction and Expression Efficiency of Bicistronic Expression Vector DV%双顺反子表达载体DV的构建及其表达效率

    Institute of Scientific and Technical Information of China (English)

    张丽星; 张喜珍; 王玉倩; 刘晨露; 夏秋; 孔维; 于湘晖; 张海红

    2011-01-01

    Objective To construct a bicistronic expression vector DV and determine its expression efficiency. Methods BGH gene and promoter CMV-intronA gene fragments were amplified by PCR using vector VR1012 as a template, and inserted into the corresponding sites between promoter and terminator of vector VR1012 to construct bicistronic expression vector DV. Luciferase gene fragment as a report gene was amplified by PCR using plasmid pshuttle-luciferase as a template and cloned into vector DV behind the two promoters respectively to obtain new vectors DV-lucl and DV-luc2. COS-7 cells were transfected with DV-lucl, DV-Iuc2 and pshuttle-luciferase respectively, then determined for the expression levels of luciferase by Western blot and the ability of luciferase in substrate degradation by enzyme-labeled fluorescent apparatus. Results Restriction analysis proved that bicistronic expression vector DV was constructed correctly. Luciferase was expressed in both the COS-7 cells transfected with DV-lucl and DV-Iuc2, while the expression efficiencies in the latter was slightly higher than that in the former. Conclusion Bicistronic expression vector DV was successfully constructed, of which the priming efficiency of promoter 2 was slightly higher than that of promoter 1. It laid a foundtion of studies on gene therapy, transcriptional regulation and multivalent vaccine.%目的 构建双顺反子表达载体DV,并检测其表达效率.方法 以载体VR1012为模板,PCR扩增BGH基因和启动子CMV-intronA基因片段,分别连接至载体VR1012启动子和终止子之间的相应位点上,构建双顺反子表达载体DV.另以质粒pshuttle-luciferase为模板,PCR扩增报告基因luciferase片段,分别连接至DV的两个启动子后,得到质粒DV-luc1和DVluc2.将质粒DV-luc1、DV-luc2和阳性质粒pshuttle-luciferase分别转染COS-7细胞,Western blot检测lucfferase蛋白的表达情况,荧光酶标仪检测luciferase降解底物的水平.结果 双顺反子表达载体DV

  7. Construction and characterization in vitro of a bicistronic retroviral vector coding endostatin and interleukin-2 for use in gene therapy; Construcao e caracterizacao in vitro de um vetor retroviral bicistronico codificando endostatina e interleucina-2 para utilizacao em terapia genica

    Energy Technology Data Exchange (ETDEWEB)

    Calvo, Fernanda Bernardes

    2009-07-01

    Gene therapy has been used in preclinical studies and clinical trials in order to alleviate or cure a disease. Retroviral vectors are a tool for gene transfer is widely used. Bicistronic vectors are an attractive alternative for treatment of complex diseases. A variety of options exists to simultaneously express two genes in genetically modified cells. The most common approach relies on bicistronic vectors in which the genes are linked to each other by an internal ribosome entry site allowing co-translational expression of both cistrons. Endostatin, the C-terminal fragment of collagen XVIII, is a potent angiogenesis inhibitor. At present, ES has been widely used in anti-angiogenic in a variety of experimental tumor models, and clinical trials to test it as an anti-tumor agent are already under way. Immunotherapy has been used as adjuvant treatment for tumors and has been used in several preclinical studies and clinical trials. The objective of this project was to construct and characterize 'in vitro' an IRES-based bicistronic retroviral vector encoding endostatin and interleukin-2. The construction of the vector was performed in three stages, the final construction was analyzed by restriction analysis and sequencing. Packaging cells were prepared. The endostatin and interleukin-2 levels were determined by Dot blot. Monocistronic and bicistronic mRNA expression were analyzed by real time RT-PCR. Bicistronic vector showed high levels of virus trites, ranging from 4.20x10{sup 5} to 1.53x10{sup 6}UFC/ml. Secreted levels of endostatin and interleukin-2 ranged from 1.08 to 2.08{mu}g/10{sup 6}cells.24h and 0.66 - 0.89{mu}g/10{sup 6}cells.24h, respectively. The mRNA expression of ES in the NIH3T3 clone pLend-IRES-IL2SN was 2 times higher than the level presented by the NIH3T3 clone pLendSN. The endostatin promoted inhibition (40%) of endothelial cell proliferation. Interleukin-2 promoted a proliferation of 10.6% lymphocytes CD4 and 8.9% of CD8. We conclude that

  8. Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma

    International Nuclear Information System (INIS)

    Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered by their immunogenicity and the presence of anti-Ad immunity in humans. We reported the efficacy of a gene therapy approach for glioma consisting of intratumoral injection of Ads encoding conditionally cytotoxic herpes simplex type 1 thymidine kinase (Ad-TK) and the immunostimulatory cytokine fms-like tyrosine kinase ligand 3 (Ad-Flt3L). Herein, we report the biodistribution, efficacy, and neurological and systemic effects of a bicistronic high-capacity Ad, i.e., HC-Ad-TK/TetOn-Flt3L. HC-Ads elicit sustained transgene expression, even in the presence of anti-Ad immunity, and can encode large therapeutic cassettes, including regulatory elements to enable turning gene expression “on” or “off” according to clinical need. The inclusion of two therapeutic transgenes within a single vector enables a reduction of the total vector load without adversely impacting efficacy. Because clinically the vectors will be delivered into the surgical cavity, normal regions of the brain parenchyma are likely to be transduced. Thus, we assessed any potential toxicities elicited by escalating doses of HC-Ad-TK/TetOn-Flt3L (1 × 108, 1 × 109, or 1 × 1010 viral particles [vp]) delivered into the rat brain parenchyma. We assessed neuropathology, biodistribution, transgene expression, systemic toxicity, and behavioral impact at acute and chronic time points. The results indicate that doses up to 1 × 109 vp of HC-Ad-TK/TetOn-Flt3L can be safely delivered into the normal rat brain and underpin further developments for its implementation in a phase I clinical trial for glioma. - Highlights: ► High capacity Ad vectors elicit sustained therapeutic gene expression in the brain. ► HC-Ad-TK/TetOn-Flt3L encodes two therapeutic genes and a transcriptional switch. ► We performed a dose escalation study at acute and chronic time

  9. Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Puntel, Mariana [Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5689 (United States); Department of Cell and Developmental Biology, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5689 (United States); Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048 (United States); Ghulam, Muhammad A.K.M. [Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048 (United States); Farrokhi, Catherine [Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, CA 90048 (United States); VanderVeen, Nathan; Paran, Christopher; Appelhans, Ashley [Department of Neurosurgery, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5689 (United States); Department of Cell and Developmental Biology, The University of Michigan School of Medicine, MSRB II, RM 4570C, 1150 West Medical Center Drive, Ann Arbor, MI 48109-5689 (United States); Kroeger, Kurt M.; Salem, Alireza [Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048 (United States); Lacayo, Liliana [Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, CA 90048 (United States); Pechnick, Robert N. [Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, CA 90048 (United States); Department of Psychiatry and Behavioral Neurosciences, David Geffen School of Medicine, University of California, Los Angeles, CA (United States); Kelson, Kyle R.; Kaur, Sukhpreet; Kennedy, Sean [Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048 (United States); Palmer, Donna; Ng, Philip [Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 (United States); and others

    2013-05-01

    Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered by their immunogenicity and the presence of anti-Ad immunity in humans. We reported the efficacy of a gene therapy approach for glioma consisting of intratumoral injection of Ads encoding conditionally cytotoxic herpes simplex type 1 thymidine kinase (Ad-TK) and the immunostimulatory cytokine fms-like tyrosine kinase ligand 3 (Ad-Flt3L). Herein, we report the biodistribution, efficacy, and neurological and systemic effects of a bicistronic high-capacity Ad, i.e., HC-Ad-TK/TetOn-Flt3L. HC-Ads elicit sustained transgene expression, even in the presence of anti-Ad immunity, and can encode large therapeutic cassettes, including regulatory elements to enable turning gene expression “on” or “off” according to clinical need. The inclusion of two therapeutic transgenes within a single vector enables a reduction of the total vector load without adversely impacting efficacy. Because clinically the vectors will be delivered into the surgical cavity, normal regions of the brain parenchyma are likely to be transduced. Thus, we assessed any potential toxicities elicited by escalating doses of HC-Ad-TK/TetOn-Flt3L (1 × 10{sup 8}, 1 × 10{sup 9}, or 1 × 10{sup 10} viral particles [vp]) delivered into the rat brain parenchyma. We assessed neuropathology, biodistribution, transgene expression, systemic toxicity, and behavioral impact at acute and chronic time points. The results indicate that doses up to 1 × 10{sup 9} vp of HC-Ad-TK/TetOn-Flt3L can be safely delivered into the normal rat brain and underpin further developments for its implementation in a phase I clinical trial for glioma. - Highlights: ► High capacity Ad vectors elicit sustained therapeutic gene expression in the brain. ► HC-Ad-TK/TetOn-Flt3L encodes two therapeutic genes and a transcriptional switch. ► We performed a dose escalation study at

  10. High-level expression of cancer/testis antigen NY-ESO-1 and human granulocyte-macrophage colony-stimulating factor in dendritic cells with a bicistronic retroviral vector.

    Science.gov (United States)

    Batchu, R B; Moreno, A M; Szmania, S; Gupta, S K; Zhan, F; Rosen, N; Kozlowski, M; Spencer, T; Spagnoli, G C; Shaughnessy, J; Barlogie, B; Tricot, G; van Rhee, F

    2003-09-20

    Tumor-specific genes delivered to dendritic cells (DCs) have been used for the generation of cytotoxic T cells (CTLs), but their application has been limited on the one hand by low viral titers resulting in low transduction efficiency and poor protein production, and on the other hand by immunogenicity of the selectable marker and poor viability of the DCs. We addressed these limitations by creating a multipurpose master vector (pMV) and cloning the tumor gene NY-ESO-1, which is highly expressed in more than 50% of advanced myeloma patients. pMV was constructed from a Moloney murine leukemia virus (Mo-MuLV)-based retroviral backbone with the following features: (1) an extended packaging signal to achieve high viral titers, (2) a splice acceptor region to facilitate protein production, (3) a nonimmunogenic selectable marker, dihydrofolate reductase-L22Y (DHFR(L22Y)), to exclude the generation of CTLs against the selectable marker, (4) an internal ribosomal entry site between the tumor-specific gene (NY-ESO-1) and the selectable marker DHFR(L22Y) for coexpression of two heterologous gene products from a single bicistronic mRNA, minimizing the possibility of differential expression of these two genes, and (5) human granulocyte-macrophage colony-stimulating factor (hGM-CSF) cDNA driven by the human T-lymphotropic virus promoter to enhance DC function and viability. Recombinant virus of pMV-NY-ESO-1 was generated with vesicular stomatitis virus G envelope protein (VSV-G) in the GP2-293 cell line for efficient transduction. We present evidence that the DC phenotype is unaltered after transduction and that more than 85% of DCs express NY-ESO-1, which secrete approximately 40 ng of GM-CSF per 10(6) DCs. PMID:14503968

  11. Construction of a bicistronic recombinant adenoviral vector for human interleukin-10 and enhanced green fluorescent protein expression in bone marrow mesenchymal stem cells

    Institute of Scientific and Technical Information of China (English)

    LIN Jian-qing; LIN Cai-zhu; LIN Xian-zhong; ZENG Kai; GAO You-guang

    2012-01-01

    Background Human interleukin-10 (hlL-10) is a cytokine synthesis inhibitory factor,which is involved in various immune responses.The purpose of this study was to construct an adenoviral vector carrying the hlL-10 gene for expression of biologically active hlL-10 in rat bone marrow mesenchymal stem cells (rMSCs).Methods A pSNAV2.0-hlL10 plasmid was used as a template to obtain a hlL-10 cDNA fragment that was subcloned by restriction enzyme digestion and ligation into a pDC316-IRES-EGFP-lacZ alpha plasmid carrying an enhanced green fluorescent protein (EGFP) marker gene.The pDC316-hlL-10-IRES-EGFP plasmid was linearized by Pmel digestion and used to transfect HEK293 packaging cells using the adenovirus packaging system AdMax.Virus particles were amplified by repeatedly infecting HEK293 cells with the seed virus and then purified by ion exchange.After the number of virus particles and titer was determined,rMSCs were infected with the adenoviral vector.The infection rate was determined by fluorescence microscopy and flow cytometry,and hlL-10 protein expression in rMSCs was measured by Western blotting.Results The virus particle concentration,OD260/280 value and virus titer of the amplified and purified recombinant adenovirus were 3.2×1011 VP/ml,approximately 2.0,and 1.1×1010 TCID50/ml,respectively.Bright green fluorescence was observed by fluorescence microscopy and flow cytometry in the recombinant adenovirus-infected rMSCs.GFP expression was considered the multiplicity of infection (MOI) and was time-dependent.The infection rate was 92.9% at 100 MOI.Conclusions A bicistrenic recombinant adenoviral vector for hlL-10 and EGFP gene expression were successfully constructed.The infection rate of rMSCs by the adenovirus was high (92.9% at 100 MOI) and the target gene hlL-10 was highly expressed in cells.The present study provides an experimental basis for further research of immunosuppressive therapy using hlL-10.The expression level of hlL-10 protein as detected by

  12. A bicistronic retroviral vector to introduce drug resistance genes into human umbilical cord blood CD34+ cells to improve combination chemotherapy tolerance%双功能逆转录病毒载体介导耐药基因转染人脐血CD34+细胞能增强联合化疗抗性

    Institute of Scientific and Technical Information of China (English)

    王季石; 陈子兴; 夏学鸣; 阮长耿; 卢大儒; 薛京伦

    2001-01-01

    Objective To study whether human umbilical cord blood CD34+ cells transduced with human aldehyde dehydrogenase class-1 (ALDH-1) and multidrug resistance gene (MDR1) have increases resistance to 4-Hydroperoxycyclo-phosphamide (4-HC) and P-glycoprotein effluxed drugs. Methods A bicistronic retroviral vector G1Na-ALDH1-IRES-MDR1 was constructed and used to transfect the packaging cell lines GP+E86 and PA317 by LipofectAMINE method, using the medium containing VCR and 4-HC agents for cloning selection and ping-ponging supernatant infection between the ecotropic producer clone and the amphotropic producer clone, we obtained high titer amphotropic PA317 producing cells with high titers up to 5.6×105 CFU/ml. Cord blood CD34+ cells were transfected repeatedly with supernatant of retrovirus containing human ALDH-1 and MDR1cDNA under the stimulation of hemopoietic growth factors. Results Bicistronic retroviral vector construction was verified by restriction endonuclease analysis. Polymerase chain reaction (PCR), reverse transcription (RT)-PCR, Southern blot, Northern blot, fluorescenceactivated cell sorting (FACS) method and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analyses showed that dual drug resistance genes have been integrated into the genomic DNA of cord blood CD34+ cells and expressed efficiently. The transgenes recipient cells confered 4-fold stronger resistance to 4-HC and 5.5 to 7.2-fold P-glycoprotein effluxed drug than untransduced cells. Conclusion The bicistronic retroviral vector-mediated transfer of two different types of drug resistance genes into human cord blood CD34+ cells and co-expression provided an experimental foundation for improving combination chemotherapy tolerance in tumor clinical trial.%目的为探讨转染醛脱氢酶基因(ALDH1)和多药耐药基因 (MDR1)的人脐血CD34+细胞能否同吮增强对活性环磷酰胺(4-HC)和P-gp转运泵靶药的抗性。 方法构建了同时含ALDH1和MDR1双

  13. Construction and Co-expression of Bicistronic Plasmid Encoding Human WEE1 and Stem Cell Factor

    Institute of Scientific and Technical Information of China (English)

    Ping LEI; Wen-Han LI; Wen-Jun LIAO; Bing YU; Hui-Fen ZHU; Jing-Fang SHAO; Guan-Xin SHEN

    2005-01-01

    To protect the hematopoietic stem cells (HSCs) from apoptosis induced by chemotherapy and promote HSC proliferation, bi-functional gene delivery systems are increasingly investigated in gene therapy.In the present study, we constructed a bicistronic vector, pWISG, expressing the anti-apoptotic protein human WEE1 (WEE1Hu) and the fusion protein of the proliferation-stimulating stem cell factor (SCF) and enhanced green fluorescent protein (EGFP) separately with internal ribosome entry site (IRES). We first examined the expression and location of WEE1Hu in Chinese hamster ovary (CHO) cells and showed that WEE1Hu was located in the nucleus, which was confirmed by immunohistochemistry and Western blot. We determined the expression and receptor-binding ability of the SCF-EGFP fusion protein on CD34+ cells,which were proved by reverse transcription polymerase chain reaction (RT-PCR) and flow cytometry,respectively. Furthermore, inhibition of cisplatin-induced apoptosis was observed in CD34+ cells transfected with pWISG, which implies that protection for CD34+ cells was achieved via WEE1Hu and SCF-EGFP. Our study suggests that the introduction of two functional genes via bicistronic vector is more powerful and efficient than single gene therapy.

  14. Bicistronic expression plasmid for the rapid production of recombinant fused proteins in Escherichia coli.

    Science.gov (United States)

    Yero, Daniel; Pajón, Rolando; Niebla, Olivia; Sardiñas, Gretel; Vivar, Isbel; Perera, Yasser; García, Darien; Delgado, Maité; Cobas, Karem

    2006-04-01

    In the post-genomic era, every aspect of the production of proteins must be accelerated. In this way, several vectors are currently exploited for rapid production of recombinant proteins in Escherichia coli. N-terminal fusions to the first 47 amino acids of the LpdA (dihydrolipoamide dehydrogenase A) protein of Neisseria meningitidis have been shown to increase the expression of recombinant proteins. Consequently, we have constructed a modified N-terminal LpdA fusion vector, introducing the blue/white colony selection by exploiting a bicistronic gene organization. In the new vector, the sequence encoding the first 47 amino acids of meningococcal LpdA and the alpha-peptide sequence of beta-galactosidase were connected via a ribosome-binding site, and two MCSs (multiple cloning sites) were located surrounding the latter, allowing efficient cloning by colour selection of recombinants. The vector was also improved with the addition of a C-terminal polyhistidine tag, and an EKS (enterokinase recognition sequence) immediately after the LpdA fusion sequence. The new plasmid was employed in the expression and purification of six different bacterial polypeptides. One of these recombinant proteins, P6 protein from Haemophilus influenzae, was used as a model and its N-terminal fusion sequence was totally removed from the recombinant version after incubation with the enterokinase protease, while the polyhistidine tail successfully allowed the purification of the unfused protein from the protease reaction. Two completely new neisserial vaccine candidates, NMB0088 and NMB1126 proteins, were cloned, expressed and purified using this system. To our knowledge, this constitutes the first report of the cloning and expression of these proteins in E. coli.

  15. A Bicistronic DNA Vaccine Containing Gene of FMDV and Bovine IFN-a Can Prime Humoral and Cellular Immune Responses of Guinea Pigs

    OpenAIRE

    Guo, Huichen; Sun, Shiqi; Ma, Jiangtao; Liu, Zaixin; Liu, Xiangtao; Xie, Qingge

    2008-01-01

    The study was conducted to evaluate the immunogenicity and protective efficacy of a DNA vaccine against foot-and-mouth disease virus (FMDV). Genes encoding the P1, 2A, 3C of FMDV O/China99 and bovine IFN-a were cloned into pcDNA3.1 (+) expression vector under CMV promoter and FMDV IRES control, respectively. The recombinant plasmids were administered to guinea pigs by intramuscular injection with mono- or bicistronic expression plasmids and aurintricarboxylic acid (ATA). After 2 sequential va...

  16. A GFP-lacZ bicistronic reporter system for promoter analysis in environmental gram-negative bacteria.

    Directory of Open Access Journals (Sweden)

    Rafael Silva-Rocha

    Full Text Available Here, we describe a bicistronic reporter system for the analysis of promoter activity in a variety of gram-negative bacteria at both the population and single-cell levels. This synthetic genetic tool utilizes an artificial operon comprising the gfp and lacZ genes that are assembled in a suicide vector, which is integrated at specific sites within the chromosome of the target bacterium, thereby creating a monocopy reporter system. This tool was instrumental for the complete in vivo characterization of two promoters, Pb and Pc, that drive the expression of the benzoate and catechol degradation pathways, respectively, of the soil bacterium Pseudomonas putida KT2440. The parameterization of these promoters in a population (using β-galactosidase assays and in single cells (using flow cytometry was necessary to examine the basic numerical features of these systems, such as the basal and maximal levels and the induction kinetics in response to an inducer (benzoate. Remarkably, GFP afforded a view of the process at a much higher resolution compared with standard lacZ tests; changes in fluorescence faithfully reflected variations in the transcriptional regimes of individual bacteria. The broad host range of the vector/reporter platform is an asset for the characterization of promoters in different bacteria, thereby expanding the diversity of genomic chasses amenable to Synthetic Biology methods.

  17. ER-alpha-cDNA as part of a bicistronic transcript gives rise to high frequency, long term, receptor expressing cell clones.

    Directory of Open Access Journals (Sweden)

    Michal Shenfeld

    Full Text Available Within the large group of Estrogen Receptor alpha (ERα-negative breast cancer patients, there is a subgroup carrying the phenotype ERα(-, PR(-, and Her2(-, named accordingly "Triple-Negative" (TN. Using cell lines derived from this TN group, we wished to establish cell clones, in which ERα is ectopically expressed, forming part of a synthetic lethality screening system. Initially, we generated cell transfectants expressing a mono-cistronic ERα transcription unit, adjacent to a separate dominant selectable marker transcription unit. However, the yield of ERα expressing colonies was rather low (5-12.5%, and only about half of these displayed stable ectopic ERα expression over time. Generation and maintenance of such cell clones under minimal exposure to the ERα ligand, did not improve yield or expression stability. Indeed, other groups have also reported grave difficulties in obtaining ectopic expression of ERα in ERα-deficient breast carcinoma cells. We therefore switched to transfecting these cell lines with pERα-IRES, a plasmid vector encoding a bicistronic translation mRNA template: ERα Open Reading Frame (ORF being upstream followed by a dominant-positive selectable marker (hygro(R ORF, directed for translation from an Internal Ribosome Entry Site (IRES. Through usage of this bicistronic vector linkage system, it was possible to generate a very high yield of ERα expressing cell clones (50-100%. The stability over time of these clones was also somewhat improved, though variations between individual cell clones were evident. Our successful experience with ERα in this system may serve as a paradigm for other genes where ectopic expression meets similar hardships.

  18. Off-the-shelf adenoviral-mediated immunotherapy via bicistronic expression of tumor antigen and iMyD88/CD40 adjuvant.

    Science.gov (United States)

    Kemnade, Jan Ole; Seethammagari, Mamatha; Narayanan, Priya; Levitt, Jonathan M; McCormick, Alison A; Spencer, David M

    2012-07-01

    Recent modest successes in ex vivo dendritic cell (DC) immunotherapy have motivated continued innovation in the area of DC manipulation and activation. Although ex vivo vaccine approaches continue to be proving grounds for new DC manipulation techniques, the intrinsic limits of ex vivo therapy, including high cost, minimal standardization, cumbersome delivery, and poor accessibility, incentivizes the development of vaccines compatible with in vivo DC targeting. We describe here a method to co-deliver both tumor-specific antigen (TSA) and an iMyD88/CD40 adjuvant (iMC), to DCs that combines toll-like receptor (TLR) and CD40 signaling. In this study, we demonstrate that simple TSA delivery via adenoviral vectors results in strong antitumor immunity. Addition of iMC delivered in a separate vector is insufficient to enhance this effect. However, when delivered simultaneously with TSA in a single bicistronic vector (BV), iMC is able to significantly enhance antigen-specific cytotoxic T-cell (CTL) responses and inhibit established tumor growth. This study demonstrates the spatial-temporal importance of concurrent DC activation and TSA presentation. Further, it demonstrates the feasibility of in vivo molecular enhancement of DCs necessary for effective antitumor immune responses.

  19. A combinatorial bidirectional and bicistronic approach for coordinated multi-gene expression in corn.

    Science.gov (United States)

    Kumar, Sandeep; AlAbed, Diaa; Whitteck, John T; Chen, Wei; Bennett, Sara; Asberry, Andrew; Wang, Xiujuan; DeSloover, Daniel; Rangasamy, Murugesan; Wright, Terry R; Gupta, Manju

    2015-03-01

    Transgene stacking in trait development process through genetic engineering is becoming complex with increased number of desired traits and multiple modes of action for each trait. We demonstrate here a novel gene stacking strategy by combining bidirectional promoter (BDP) and bicistronic approaches to drive coordinated expression of multi-genes in corn. A unidirectional promoter, Ubiquitin-1 (ZMUbi1), from Zea mays was first converted into a synthetic BDP, such that a single promoter can direct the expression of two genes from each end of the promoter. The BDP system was then combined with a bicistronic organization of genes at both ends of the promoter by using a Thosea asigna virus 2A auto-cleaving domain. With this gene stacking configuration, we have successfully obtained expression in transgenic corn of four transgenes; three transgenes conferring insect (cry34Ab1 and cry35Ab1) and herbicide (aad1) resistance, and a phiyfp reporter gene using a single ZMUbi1 bidirectional promoter. Gene expression analyses of transgenic corn plants confirmed better coordinated expression of the four genes compared to constructs driving each gene by independent unidirectional ZmUbi1 promoter. To our knowledge, this is the first report that demonstrates application of a single promoter for co-regulation of multiple genes in a crop plant. This stacking technology would be useful for engineering metabolic pathways both for basic and applied research. PMID:25657118

  20. Use of the viral 2A peptide for bicistronic expression in transgenic mice

    Directory of Open Access Journals (Sweden)

    Trichas Georgios

    2008-09-01

    Full Text Available Abstract Background Transgenic animals are widely used in biomedical research and biotechnology. Multicistronic constructs, in which several proteins are encoded by a single messenger RNA, are commonly used in genetically engineered animals. This is currently done by using an internal ribosomal entry site to separate the different coding regions. 2A peptides result in the co-translational 'cleavage' of proteins and are an attractive alternative to the internal ribosomal entry site. They are more reliable than the internal ribosomal entry site and lead to expression of multiple cistrons at equimolar levels. They work in a wide variety of eukaryotic cells, but to date have not been demonstrated to function in transgenic mice in an inheritable manner. Results To test 2A function in transgenic mice and uncover any possible toxicity of widespread expression of the 2A peptide, we made a bicistronic reporter construct containing the coding sequence for a membrane localised red fluorescent protein (Myr-TdTomato and a nuclear localised green fluorescent protein (H2B-GFP, separated by a 2A sequence. When this reporter is transfected into HeLa cells, the two fluorescent proteins correctly localise to mutually exclusive cellular compartments, demonstrating that the bicistronic construct is a reliable readout of 2A function. The two fluorescent proteins also correctly localise when the reporter is electroporated into chick neural tube cells. We made two independent transgenic mouse lines that express the bicistronic reporter ubiquitously. For both lines, transgenic mice are born in Mendelian frequencies and are found to be healthy and fertile. Myr-TdTomato and H2B-GFP segregate to mutually exclusive cellular compartments in all tissues examined from a broad range of developmental stages, ranging from embryo to adult. One transgenic line shows X-linked inheritance of the transgene and mosaic expression in females but uniform expression in males, indicating

  1. Application of two bicistronic systems involving 2A and IRES sequences to the biosynthesis of carotenoids in rice endosperm.

    Science.gov (United States)

    Ha, Sun-Hwa; Liang, Ying Shi; Jung, Harin; Ahn, Mi-Jeong; Suh, Seok-Cheol; Kweon, Soon-Jong; Kim, Dong-Hern; Kim, Young-Mi; Kim, Ju-Kon

    2010-10-01

    Coordination of multiple transgenes is essential for metabolic engineering of biosynthetic pathways. Here, we report the utilization of two bicistronic systems involving the 2A sequence from the foot-and-mouth disease virus and the internal ribosome entry site (IRES) sequence from the crucifer-infecting tobamovirus to the biosynthesis of carotenoids in rice endosperm. Two carotenoid biosynthetic genes, phytoene synthase (Psy) from Capsicum and carotene desaturase (CrtI) from Pantoea, were linked via either the synthetic 2A sequence that was optimized for rice codons or the IRES sequence under control of the rice globulin promoter, generating PAC (Psy-2A-CrtI) and PIC (Psy-IRES-CrtI) constructs, respectively. The transgenic endosperm of PAC rice had a more intense golden color than did PIC rice, demonstrating that 2A was more efficient than IRES in coordinating gene expression. The 2A and IRES constructs were equally effective in driving transgene transcription. However, immunoblot analysis of CRTI, a protein encoded by the downstream open reading frame of the bicistronic constructs, revealed that 2A was ninefold more effective than IRES in driving translation. The PAC endosperms accumulated an average of 1.3 μg/g of total carotenoids, which was ninefold higher than was observed for PIC endosperms. In particular, accumulation of β-carotene was much higher in PAC endosperms than in PIC endosperms. Collectively, these results demonstrate that both 2A and IRES systems can coordinate the expression of two biosynthetic genes, with the 2A system exhibiting greater efficiency. Thus, the 2A expression system described herein is an effective new tool for multigene stacking in crop biotechnology. PMID:20649940

  2. Expression of chicken parvovirus VP2 in chicken embryo fibroblasts requires codon optimization for production of naked DNA and vectored meleagrid herpesvirus type 1 vaccines.

    Science.gov (United States)

    Spatz, Stephen J; Volkening, Jeremy D; Mullis, Robert; Li, Fenglan; Mercado, John; Zsak, Laszlo

    2013-10-01

    Meleagrid herpesvirus type 1 (MeHV-1) is an ideal vector for the expression of antigens from pathogenic avian organisms in order to generate vaccines. Chicken parvovirus (ChPV) is a widespread infectious virus that causes serious disease in chickens. It is one of the etiological agents largely suspected in causing Runting Stunting Syndrome (RSS) in chickens. Initial attempts to express the wild-type gene encoding the capsid protein VP2 of ChPV by insertion into the thymidine kinase gene of MeHV-1 were unsuccessful. However, transient expression of a codon-optimized synthetic VP2 gene cloned into the bicistronic vector pIRES2-Ds-Red2, could be demonstrated by immunocytochemical staining of transfected chicken embryo fibroblasts (CEFs). Red fluorescence could also be detected in these transfected cells since the red fluorescent protein gene is downstream from the internal ribosome entry site (IRES). Strikingly, fluorescence could not be demonstrated in cells transiently transfected with the bicistronic vector containing the wild-type or non-codon-optimized VP2 gene. Immunocytochemical staining of these cells also failed to demonstrate expression of wild-type VP2, indicating that the lack of expression was at the RNA level and the VP2 protein was not toxic to CEFs. Chickens vaccinated with a DNA vaccine consisting of the bicistronic vector containing the codon-optimized VP2 elicited a humoral immune response as measured by a VP2-specific ELISA. This VP2 codon-optimized bicistronic cassette was rescued into the MeHV-1 genome generating a vectored vaccine against ChPV disease.

  3. Remarkable stability of an instability-prone lentiviral vector plasmid in Escherichia coli Stbl3

    OpenAIRE

    Al-Allaf, Faisal A.; Tolmachov, Oleg E.; Zambetti, Lia Paola; Tchetchelnitski, Viktoria; Mehmet, Huseyin

    2012-01-01

    Large-scale production of plasmid DNA to prepare therapeutic gene vectors or DNA-based vaccines requires a suitable bacterial host, which can stably maintain the plasmid DNA during industrial cultivation. Plasmid loss during bacterial cell divisions and structural changes in the plasmid DNA can dramatically reduce the yield of the desired recombinant plasmid DNA. While generating an HIV-based gene vector containing a bicistronic expression cassette 5′-Olig2cDNA-IRES-dsRed2-3′, we encountered ...

  4. Ser2 is the autophosphorylation site in the beta subunit from bicistronically expressed human casein kinase-2 and from native rat liver casein kinase-2 beta

    DEFF Research Database (Denmark)

    Boldyreff, B; James, P; Staudenmann, W;

    1993-01-01

    suggests that the enzyme is already heavily phosphorylated. ESI analysis also revealed Ser2 as the only phosphorylated residue at the amino terminus. In the case of both recombinant human CK-2 and native rat liver CK-2, treatment with alkaline phosphatase readily reversed the phosphorylated form......Human casein kinase-2 (CK-2) subunits alpha and beta were bicistronically expressed in bacteria. The recombinant holoenzyme shared all investigated properties with the native CK-2 from mammalian sources (rat liver, Krebs II mouse ascites tumour cells). Contrary to recombinant human CK-2 produced...... with either the phosphorylated or the unphosphorylated form of CK-2 did not differ significantly, suggesting that the autophosphorylation had no influence on the kinetic parameters Km and Vmax. In parallel, native rat liver CK-2 beta subunit was shown to incorporate 0.1 mol phosphate/mol holoenzyme, which...

  5. Mutational library analysis of selected amino acids in the receptor binding domain of envelope of Akv murine leukemia virus by conditionally replication competent bicistronic vectors

    DEFF Research Database (Denmark)

    Bahrami, Shervin; Pedersen, Finn Skou; Duch, Mogens R.;

    2003-01-01

    ) and the neomycin phosphotransferase II (Neo) selection marker from the same transcript. Envelope expression was achieved by inserting an internal ribosome entry site (IRES) between the neo and the env genes. We found the structure of the linker between the IRES element and env to be critical for sufficient...

  6. Easy expression of the C-terminal heavy chain domain of botulinum neurotoxin serotype A as a vaccine candidate using a bi-cistronic baculovirus system.

    Science.gov (United States)

    Villaflores, Oliver B; Hsei, Chein-Ming; Teng, Chao-Yi; Chen, Ying-Ju; Wey, Jiunn-Jye; Tsui, Pei-Yi; Shyu, Rong-Hwa; Tung, Kuo-Lun; Yeh, Jui-Ming; Chiao, Der-Jiang; Wu, Tzong-Yuan

    2013-04-01

    Clostridial botulinum neurotoxin (BoNT) is one of the most toxic proteins causing the food borne disease, botulism. In previous studies, recombinant BoNT production by Escherichia coli and yeast Pichia pastoris has been hampered by high AT content and codon bias in the gene encoding BoNT and required a synthetic gene to resolve this intrinsic bottleneck. This paper reports the simultaneous expression of the C-terminal heavy chain domain of BoNT (rBoNT/A-HC-6h) and enhanced green fluorescent protein (EGFP) using a bi-cistronic baculovirus-insect cell expression system. The expression of EGFP facilitated the monitoring of viral infection, virus titer determination, and isolation of the recombinant virus. Protein fusion with hexa-His-tag and one-step immobilized metal-ion affinity chromatography (IMAC) purification produced a homogenous, stable, and immunologically active 55-kDa rBoNT/A-HC-6h (about 3mg/L) with >90% purity. Furthermore, measured levels of serum titers were 8-folds for mice vaccinated with the purified rBoNT/A-HC-6h (2μg) than for mice administered with botulinum toxoid after initial immunization. Challenge experiment with botulinum A toxin demonstrated the immunoprotective activity of purified rBoNT/A-HC-6h providing the mice full protection against 10(2) LD50 botulinum A toxin with a dose as low as 0.2μg. This study provided supportive evidence for the use of a bi-cistronic baculovirus-Sf21 insect cell expression system in the facile expression of an immunogenically active rBoNT/A-HC. PMID:23313783

  7. Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI

    Directory of Open Access Journals (Sweden)

    Margison Geoffrey P

    2006-03-01

    Full Text Available Abstract Background A number of gene therapy applications would benefit from vectors capable of expressing multiple genes. In this study we explored the feasibility and efficiency of expressing two or three transgenes in HIV-1 based lentiviral vector. Bicistronic and tricistronic self-inactivating lentiviral vectors were constructed employing the internal ribosomal entry site (IRES sequence of encephalomyocarditis virus (EMCV and/or foot-and-mouth disease virus (FMDV cleavage factor 2A. We employed enhanced green fluorescent protein (eGFP, O6-methylguanine-DNA-methyltransferase (MGMT, and homeobox transcription factor HOXB4 as model genes and their expression was detected by appropriate methods including fluorescence microscopy, flow cytometry, immunocytochemistry, biochemical assay, and western blotting. Results All the multigene vectors produced high titer virus and were able to simultaneously express two or three transgenes in transduced cells. However, the level of expression of individual transgenes varied depending on: the transgene itself; its position within the construct; the total number of transgenes expressed; the strategy used for multigene expression and the average copy number of pro-viral insertions. Notably, at limiting MOI, the expression of eGFP in a bicistronic vector based on 2A was ~4 times greater than that of an IRES based vector. Conclusion The small and efficient 2A sequence can be used alone or in combination with an IRES for the construction of multicistronic lentiviral vectors which can express encoded transgenes at functionally relevant levels in cells containing an average of one pro-viral insert.

  8. Vector analysis

    CERN Document Server

    Newell, Homer E

    2006-01-01

    When employed with skill and understanding, vector analysis can be a practical and powerful tool. This text develops the algebra and calculus of vectors in a manner useful to physicists and engineers. Numerous exercises (with answers) not only provide practice in manipulation but also help establish students' physical and geometric intuition in regard to vectors and vector concepts.Part I, the basic portion of the text, consists of a thorough treatment of vector algebra and the vector calculus. Part II presents the illustrative matter, demonstrating applications to kinematics, mechanics, and e

  9. About vectors

    CERN Document Server

    Hoffmann, Banesh

    1975-01-01

    From his unusual beginning in ""Defining a vector"" to his final comments on ""What then is a vector?"" author Banesh Hoffmann has written a book that is provocative and unconventional. In his emphasis on the unresolved issue of defining a vector, Hoffmann mixes pure and applied mathematics without using calculus. The result is a treatment that can serve as a supplement and corrective to textbooks, as well as collateral reading in all courses that deal with vectors. Major topics include vectors and the parallelogram law; algebraic notation and basic ideas; vector algebra; scalars and scalar p

  10. Sequencing of the bicistronic genome segments S7 and S9 of Mal de Río Cuarto virus (Fijivirus, Reoviridae) completes the genome of this virus.

    Science.gov (United States)

    Guzmán, F A; Distéfano, A J; Arneodo, J D; Hopp, H E; Lenardon, S L; del Vas, M; Conci, L R

    2007-01-01

    The nucleotide sequences of genomic segments S7 and S9 of Mal de Río Cuarto virus (MRCV, Fijivirus group II) have been determined, thus completing the entire genome sequence of the virus. These segments showed a non-overlapping bicistronic structure, as in other members of the genus. MRCV S7 ORF-1 had a length of 1086 bp and encoded a 41.5 kDa putative polypeptide, whereas MRCV S7 ORF-2 had a length of 930 bp and encoded a 36.8 kDa putative polypeptide. Proteins of 39 and 20.5 kDa were predicted for the 1014 bp long MRCV S9 ORF-1 and the 537 bp long MRCV S9 ORF-2, respectively. The terminal 5' and 3' sequences of both segments were 5'AAGUUUUU3' and 5'CAGCUnnnGUC3', respectively. Specific imperfect inverted repeats of each segment were identified. Comparison of the predicted proteins with those of related virus genome segments counterparts in maize rough dwarf virus (MRDV) and rice black streaked dwarf virus (RBSDV), showed 64.5-44.3% identities. These values are lower than those resulting from comparisons between MRDV and RBSDV. The topology of the trees obtained using the complete nucleotide and amino acid sequences of MRCV S7 and MRCV S9 was consistent with the analysis of the other MRCV segments previously published.

  11. A product of the bicistronic Drosophila melanogaster gene CG31241, which also encodes a trimethylguanosine synthase, plays a role in telomere protection.

    Science.gov (United States)

    Komonyi, Orban; Schauer, Tamas; Papai, Gabor; Deak, Peter; Boros, Imre M

    2009-03-15

    Although telomere formation occurs through a different mechanism in Drosophila compared with other organisms, telomere associations result from mutations in homologous genes, indicating the involvement of similar pathways in chromosome end protection. We report here that mutations of the Drosophila melanogaster gene CG31241 lead to high frequency chromosome end fusions. CG31241 is a bicistronic gene that encodes trimethylguanosine synthase (TGS1), which forms the m3G caps of noncoding small RNAs, and a novel protein, DTL. We show that although TGS1 has no role in telomere protection, DTL is localized at specific sites, including the ends of polytene chromosomes, and its loss results in telomere associations. Mutations of ATM- and Rad3-related (ATR) kinase suppress telomere fusions in the absence of DTL. Thus, genetic interactions place DTL in an ATR-related pathway in telomere protection. In contrast to ATR kinase, mutations of ATM (ataxia telangiectasia mutated) kinase, which acts in a partially overlapping pathway of telomere protection, do not suppress formation of telomere associations in the absence of DTL. Thus, uncovering the role of DTL will help to dissect the evolutionary conserved pathway(s) controlling ATM-ATR-related telomere protection.

  12. Elementary vectors

    CERN Document Server

    Wolstenholme, E Œ

    1978-01-01

    Elementary Vectors, Third Edition serves as an introductory course in vector analysis and is intended to present the theoretical and application aspects of vectors. The book covers topics that rigorously explain and provide definitions, principles, equations, and methods in vector analysis. Applications of vector methods to simple kinematical and dynamical problems; central forces and orbits; and solutions to geometrical problems are discussed as well. This edition of the text also provides an appendix, intended for students, which the author hopes to bridge the gap between theory and appl

  13. Vector analysis

    CERN Document Server

    Brand, Louis

    2006-01-01

    The use of vectors not only simplifies treatments of differential geometry, mechanics, hydrodynamics, and electrodynamics, but also makes mathematical and physical concepts more tangible and easy to grasp. This text for undergraduates was designed as a short introductory course to give students the tools of vector algebra and calculus, as well as a brief glimpse into these subjects' manifold applications. The applications are developed to the extent that the uses of the potential function, both scalar and vector, are fully illustrated. Moreover, the basic postulates of vector analysis are brou

  14. Equivalent Vectors

    Science.gov (United States)

    Levine, Robert

    2004-01-01

    The cross-product is a mathematical operation that is performed between two 3-dimensional vectors. The result is a vector that is orthogonal or perpendicular to both of them. Learning about this for the first time while taking Calculus-III, the class was taught that if AxB = AxC, it does not necessarily follow that B = C. This seemed baffling. The…

  15. Vector geometry

    CERN Document Server

    Robinson, Gilbert de B

    2011-01-01

    This brief undergraduate-level text by a prominent Cambridge-educated mathematician explores the relationship between algebra and geometry. An elementary course in plane geometry is the sole requirement for Gilbert de B. Robinson's text, which is the result of several years of teaching and learning the most effective methods from discussions with students. Topics include lines and planes, determinants and linear equations, matrices, groups and linear transformations, and vectors and vector spaces. Additional subjects range from conics and quadrics to homogeneous coordinates and projective geom

  16. Vector velocimeter

    DEFF Research Database (Denmark)

    2012-01-01

    for generation of a reference beam, a detector system comprising a first detector arrangement arranged in such a way that the signal beam and the reference beam are incident upon the first detector arrangement with the reference beam propagating at an angle relative to a signal beam, and wherein the first......The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser...... assembly for emission of a measurement beam for illumination of an object in a measurement volume with coherent light whereby a signal beam emanating from the object in the measurement volume is formed in response to illumination of the object by the measurement beam, a reference beam generator...

  17. A new generation of pPRIG-based retroviral vectors

    Directory of Open Access Journals (Sweden)

    Boulukos Kim E

    2007-11-01

    Full Text Available Abstract Background Retroviral vectors are valuable tools for gene transfer. Particularly convenient are IRES-containing retroviral vectors expressing both the protein of interest and a marker protein from a single bicistronic mRNA. This coupled expression increases the relevance of tracking and/or selection of transduced cells based on the detection of a marker protein. pAP2 is a retroviral vector containing eGFP downstream of a modified IRES element of EMCV origin, and a CMV enhancer-promoter instead of the U3 region of the 5'LTR, which increases its efficiency in transient transfection. However, pAP2 contains a limited multicloning site (MCS and shows weak eGFP expression, which previously led us to engineer an improved version, termed pPRIG, harboring: i the wild-type ECMV IRES sequence, thereby restoring its full activity; ii an optimized MCS flanked by T7 and SP6 sequences; and iii a HA tag encoding sequence 5' of the MCS (pPRIG HAa/b/c. Results The convenience of pPRIG makes it a good basic vector to generate additional derivatives for an extended range of use. Here we present several novel pPRIG-based vectors (collectively referred to as PRIGs in which : i the HA tag sequence was inserted in the three reading frames 3' of the MCS (3'HA PRIGs; ii a functional domain (ER, VP16 or KRAB was inserted either 5' or 3' of the MCS (« modular » PRIGs; iii eGFP was replaced by either eCFP, eYFP, mCherry or puro-R (« single color/resistance » PRIGs; and iv mCherry, eYFP or eGFP was inserted 5' of the MCS of the IRES-eGFP, IRES-eCFP or IRES-Puro-R containing PRIGs, respectively (« dual color/selection » PRIGs. Additionally, some of these PRIGs were also constructed in a pMigR MSCV background which has been widely used in pluripotent cells. Conclusion These novel vectors allow for straightforward detection of any expressed protein (3'HA PRIGs, for functional studies of chimeric proteins (« modular » PRIGs, for multiple transductions and

  18. Vector nematicons

    CERN Document Server

    Horikis, Theodoros P

    2016-01-01

    Families of soliton pairs, namely vector solitons, are found within the context of a coupled nonlocal nonlinear Schrodinger system of equations, as appropriate for modeling beam propagation in nematic liquid crystals. In the focusing case, bright soliton pairs have been found to exist provided their amplitudes satisfy a specific condition. In our analytical approach, focused on the defocusing regime, we rely on a multiscale expansion methods, which reveals the existence of dark-dark and antidark-antidark solitons, obeying an effective Korteweg-de Vries equation, as well as dark-bright solitons, obeying an effective Mel'nikov system. These pairs are discriminated by the sign of a constant that links all physical parameters of the system to the amplitude of the stable continuous wave solutions, and, much like the focusing case, the solitons' amplitudes are linked leading to mutual guiding.

  19. 应用2A肽策略构建双基因共表达转基因斑马鱼的研究%The Study on Application of Bicistronic Vector in Transgenic Zebrafish Based on 2A Peptide

    Institute of Scientific and Technical Information of China (English)

    张力; 刘超; 周昕; 谢英; 刘树锋

    2015-01-01

    目的 以Tol2为骨架载体,以绿色荧光蛋白(GFP)、Cherry为报告基因,探讨采用2A肽双基因载体构建策略构建单启动子双基因共表达质粒的方法;将B细胞刺激因子(BAFF)分别置于2A序列前后位置,分析位置效应对跨膜融合蛋白的表达与剪切的影响,探讨多基因共表达转基因斑马鱼构建技术.方法 以InFusion法将GFP-2A-Cherry序列构建到Tol2质粒上,所得pTol-GFP-2A-Cherry质粒转染HeLa细胞、显微注射1-细胞期斑马鱼受精卵;倒置荧光显微镜观察HeLa细胞、斑马鱼幼鱼体内GFP与Cherry蛋白的表达,Western blot法验证GFP和Cherry蛋白的表达量与剪切情况;分别构建pTol2-GFP-2A-BAFF与pTol2-BAFF-2A-Cherry质粒,Western blot法检查BAFF的表达与剪切情况.结果 pTol2-GFP-2A-Cherry质粒转染的HeLa细胞,GFP与Cherry均可单独表达且表达呈现时空一致性;GFP-2A-Cherry融合蛋白可被剪切为GFP与Cherry,且成等比例表达趋势.pTol2-GFP-2A-Cherry质粒显微注射1-细胞期斑马鱼受精卵可获得可单独表达GFP与Cherry蛋白的转基因斑马鱼;pTol2-GFP-2A-BAFF与pTol2-BAFF-2A-Cherry于斑马鱼体内均有融合蛋白的表达,且BAFF序列位于2A序列后更易于融合蛋白的剪切.结论 通过2A肽策略构建可实现在斑马鱼体内单一载体、单一启动子调控双基因表达目的.发现编码跨膜分泌蛋白的功能基因位于2A序列的不同位置会直接影响蛋白的剪切,功能基因位于2A序列后易于跨膜蛋白的剪切.

  20. Replication-competent infectious hepatitis B virus vectors carrying substantially sized transgenes by redesigned viral polymerase translation.

    Directory of Open Access Journals (Sweden)

    Zihua Wang

    Full Text Available Viral vectors are engineered virus variants able to deliver nonviral genetic information into cells, usually by the same routes as the parental viruses. For several virus families, replication-competent vectors carrying reporter genes have become invaluable tools for easy and quantitative monitoring of replication and infection, and thus also for identifying antivirals and virus susceptible cells. For hepatitis B virus (HBV, a small enveloped DNA virus causing B-type hepatitis, such vectors are not available because insertions into its tiny 3.2 kb genome almost inevitably affect essential replication elements. HBV replicates by reverse transcription of the pregenomic (pg RNA which is also required as bicistronic mRNA for the capsid (core protein and the reverse transcriptase (Pol; their open reading frames (ORFs overlap by some 150 basepairs. Translation of the downstream Pol ORF does not involve a conventional internal ribosome entry site (IRES. We reasoned that duplicating the overlap region and providing artificial IRES control for translation of both Pol and an in-between inserted transgene might yield a functional tricistronic pgRNA, without interfering with envelope protein expression. As IRESs we used a 22 nucleotide element termed Rbm3 IRES to minimize genome size increase. Model plasmids confirmed its activity even in tricistronic arrangements. Analogous plasmids for complete HBV genomes carrying 399 bp and 720 bp transgenes for blasticidin resistance (BsdR and humanized Renilla green fluorescent protein (hrGFP produced core and envelope proteins like wild-type HBV; while the hrGFP vector replicated poorly, the BsdR vector generated around 40% as much replicative DNA as wild-type HBV. Both vectors, however, formed enveloped virions which were infectious for HBV-susceptible HepaRG cells. Because numerous reporter and effector genes with sizes of around 500 bp or less are available, the new HBV vectors should become highly useful tools to

  1. Rotations with Rodrigues' Vector

    Science.gov (United States)

    Pina, E.

    2011-01-01

    The rotational dynamics was studied from the point of view of Rodrigues' vector. This vector is defined here by its connection with other forms of parametrization of the rotation matrix. The rotation matrix was expressed in terms of this vector. The angular velocity was computed using the components of Rodrigues' vector as coordinates. It appears…

  2. Concise vector analysis

    CERN Document Server

    Eliezer, C J; Maxwell, E A; Sneddon, I N

    1963-01-01

    Concise Vector Analysis is a five-chapter introductory account of the methods and techniques of vector analysis. These methods are indispensable tools in mathematics, physics, and engineering. The book is based on lectures given by the author in the University of Ceylon.The first two chapters deal with vector algebra. These chapters particularly present the addition, representation, and resolution of vectors. The next two chapters examine the various aspects and specificities of vector calculus. The last chapter looks into some standard applications of vector algebra and calculus.This book wil

  3. VectorBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — VectorBase is a Bioinformatics Resource Center for invertebrate vectors. It is one of four Bioinformatics Resource Centers funded by NIAID to provide web-based...

  4. Insulated Foamy Viral Vectors.

    Science.gov (United States)

    Browning, Diana L; Collins, Casey P; Hocum, Jonah D; Leap, David J; Rae, Dustin T; Trobridge, Grant D

    2016-03-01

    Retroviral vector-mediated gene therapy is promising, but genotoxicity has limited its use in the clinic. Genotoxicity is highly dependent on the retroviral vector used, and foamy viral (FV) vectors appear relatively safe. However, internal promoters may still potentially activate nearby genes. We developed insulated FV vectors, using four previously described insulators: a version of the well-studied chicken hypersensitivity site 4 insulator (650cHS4), two synthetic CCCTC-binding factor (CTCF)-based insulators, and an insulator based on the CCAAT box-binding transcription factor/nuclear factor I (7xCTF/NF1). We directly compared these insulators for enhancer-blocking activity, effect on FV vector titer, and fidelity of transfer to both proviral long terminal repeats. The synthetic CTCF-based insulators had the strongest insulating activity, but reduced titers significantly. The 7xCTF/NF1 insulator did not reduce titers but had weak insulating activity. The 650cHS4-insulated FV vector was identified as the overall most promising vector. Uninsulated and 650cHS4-insulated FV vectors were both significantly less genotoxic than gammaretroviral vectors. Integration sites were evaluated in cord blood CD34(+) cells and the 650cHS4-insulated FV vector had fewer hotspots compared with an uninsulated FV vector. These data suggest that insulated FV vectors are promising for hematopoietic stem cell gene therapy. PMID:26715244

  5. Rhotrix Vector Spaces

    Science.gov (United States)

    Aminu, Abdulhadi

    2010-01-01

    By rhotrix we understand an object that lies in some way between (n x n)-dimensional matrices and (2n - 1) x (2n - 1)-dimensional matrices. Representation of vectors in rhotrices is different from the representation of vectors in matrices. A number of vector spaces in matrices and their properties are known. On the other hand, little seems to be…

  6. Covariantised Vector Galileons

    CERN Document Server

    Hull, Matthew; Tasinato, Gianmassimo

    2015-01-01

    Vector galileons are ghost-free systems containing higher derivative interactions of vector fields. They break the vector gauge symmetry, and the dynamics of the longitudinal vector polarizations acquire a Galileon symmetry in an appropriate decoupling limit in Minkowski space. Using an ADM approach, we carefully reconsider the coupling with gravity of vector galileons, with the aim of studying the necessary conditions to avoid the propagation of ghosts. We develop arguments that put on a more solid footing the results previously obtained in the literature. Moreover, working in analogy with the scalar counterpart, we find indications for the existence of a `beyond Horndeski' theory involving vector degrees of freedom, that avoids the propagation of ghosts thanks to secondary constraints. In addition, we analyse a Higgs mechanism for generating vector galileons through spontaneous symmetry breaking, and we present its consistent covariantisation.

  7. Index Sets and Vectorization

    Energy Technology Data Exchange (ETDEWEB)

    Keasler, J A

    2012-03-27

    Vectorization is data parallelism (SIMD, SIMT, etc.) - extension of ISA enabling the same instruction to be performed on multiple data items simultaeously. Many/most CPUs support vectorization in some form. Vectorization is difficult to enable, but can yield large efficiency gains. Extra programmer effort is required because: (1) not all algorithms can be vectorized (regular algorithm structure and fine-grain parallelism must be used); (2) most CPUs have data alignment restrictions for load/store operations (obey or risk incorrect code); (3) special directives are often needed to enable vectorization; and (4) vector instructions are architecture-specific. Vectorization is the best way to optimize for power and performance due to reduced clock cycles. When data is organized properly, a vector load instruction (i.e. movaps) can replace 'normal' load instructions (i.e. movsd). Vector operations can potentially have a smaller footprint in the instruction cache when fewer instructions need to be executed. Hybrid index sets insulate users from architecture specific details. We have applied hybrid index sets to achieve optimal vectorization. We can extend this concept to handle other programming models.

  8. Vectorization of a Treecode

    Science.gov (United States)

    Makino, Junichiro

    1990-03-01

    Vectorized algorithms for the force calculation and tree construction in the Barnes-Hut tree algorithm are described. The basic idea for the vectorization of the force calculation is to vectorize the tree traversal across particles, so that all particles in the system traverse the tree simultaneously. The tree construction algorithm also makes use of the fact that particles can be treated in parallel. Thus these algorithms take advantage of the internal parallelism in the N-body system and the tree algorithm most effectively. As a natural result, these algorithms can be used on a wide range of vector/parallel architectures, including current supercomputers and highly parallel architectures such as the Connection Machine. The vectorized code runs about five times faster than the non-vector code on a Cyber 205 for an N-body system with N = 8192.

  9. Implicit Real Vector Automata

    Directory of Open Access Journals (Sweden)

    Jean-François Degbomont

    2010-10-01

    Full Text Available This paper addresses the symbolic representation of non-convex real polyhedra, i.e., sets of real vectors satisfying arbitrary Boolean combinations of linear constraints. We develop an original data structure for representing such sets, based on an implicit and concise encoding of a known structure, the Real Vector Automaton. The resulting formalism provides a canonical representation of polyhedra, is closed under Boolean operators, and admits an efficient decision procedure for testing the membership of a vector.

  10. Selectively Balancing Unit Vectors

    OpenAIRE

    Blokhuis, Aart; Chen, Hao

    2016-01-01

    A set $U$ of unit vectors is selectively balancing if one can find two disjoint subsets $U^+$ and $U^-$, not both empty, such that the Euclidean distance between the sum of $U^+$ and the sum of $U^-$ is smaller than $1$. We prove that, to guarantee a selectively balancing set, $n \\log n$ unit vectors suffice for sufficiently large $n$, but $\\tfrac{1}{23} n \\log n$ unit vectors won't be enough for infinitely many $n$.

  11. Custodial vector model

    DEFF Research Database (Denmark)

    Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan;

    2015-01-01

    We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a $SU(2)_L\\times SU(2)_R$ spectral global symmetry. This symmetry partially protects the electroweak S-parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum...... and interactions with the standard model fields lead to distinct signatures at the LHC in the diboson, dilepton and associated Higgs channels....

  12. Vectors and their applications

    CERN Document Server

    Pettofrezzo, Anthony J

    2005-01-01

    Geared toward undergraduate students, this text illustrates the use of vectors as a mathematical tool in plane synthetic geometry, plane and spherical trigonometry, and analytic geometry of two- and three-dimensional space. Its rigorous development includes a complete treatment of the algebra of vectors in the first two chapters.Among the text's outstanding features are numbered definitions and theorems in the development of vector algebra, which appear in italics for easy reference. Most of the theorems include proofs, and coordinate position vectors receive an in-depth treatment. Key concept

  13. Symbolic computer vector analysis

    Science.gov (United States)

    Stoutemyer, D. R.

    1977-01-01

    A MACSYMA program is described which performs symbolic vector algebra and vector calculus. The program can combine and simplify symbolic expressions including dot products and cross products, together with the gradient, divergence, curl, and Laplacian operators. The distribution of these operators over sums or products is under user control, as are various other expansions, including expansion into components in any specific orthogonal coordinate system. There is also a capability for deriving the scalar or vector potential of a vector field. Examples include derivation of the partial differential equations describing fluid flow and magnetohydrodynamics, for 12 different classic orthogonal curvilinear coordinate systems.

  14. Cosmology with vector distortion

    CERN Document Server

    Jimenez, Jose Beltran

    2016-01-01

    We consider an extension of Weyl geometry with the most general connection linearly determined by a vector field. We discuss some of the geometrical properties within this framework and then we construct gravitational theories leading to an interesting class of vector-tensor theories with cosmological applications.

  15. Switched Multistage Vector Quantizer

    Directory of Open Access Journals (Sweden)

    M Satya Sai Ram

    2010-01-01

    Full Text Available This paper investigates the use of a new hybrid vector quantizer called Switched Multi stage vector quantization (SWMSVQ technique using hard and soft decision schemes, for coding of narrow band speech signals. This technique is a hybrid of Switch vector quantization technique and Multi stage vector quantization technique. SWMSVQ quantizes the linear predictive coefficients (LPC in terms of the line spectral frequencies (LSF. The spectral distortion performance, computational complexity and memory requirements of SWMSVQ using hard and soft decision schemes are compared with Split vector quantization (SVQ technique, Multi stage vector quantization (MSVQ technique, Switched Split vector quantization (SSVQ technique using hard decision scheme, and Multi Switched Split Vector quantization (MSSVQ technique using hard decision scheme. From results it is proved that SWMSVQ using soft decision scheme is having less spectral distortion, computational complexity and memory requirements when compared to SVQ, MSVQ, SSVQ and SWMSVQ using hard decision scheme, but high when compared to MSSVQ using hard decision scheme. So from results it is proved that SWMSVQ using soft decision scheme is better when compared to SVQ, MSVQ, SSVQ and SWMSVQ using hard decision schemes in terms of spectral distortion, computational complexity and memory requirements but is having greater spectral distortion, computational complexity and memory requirements when compared to MSSVQ using hard decision.

  16. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...

  17. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... of parameter spaces into structurally stable domains, and a description of the bifurcations. For this reason, the talk will focus on these questions for complex polynomial vector fields....

  18. Line Integral of a Vector.

    Science.gov (United States)

    Balabanian, Norman

    This programed booklet is designed for the engineering student who understands and can use vector and unit vector notation, components of a vector, parallel law of vector addition, and the dot product of two vectors. Content begins with work done by a force in moving a body a certain distance along some path. For each of the examples and problem…

  19. ON VECTOR NETWORK EQUILIBRIUM PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Guangya CHEN

    2005-01-01

    In this paper we define a concept of weak equilibrium for vector network equilibrium problems.We obtain sufficient conditions of weak equilibrium points and establish relation with vector network equilibrium problems and vector variational inequalities.

  20. GAP Land Cover - Vector

    Data.gov (United States)

    Minnesota Department of Natural Resources — This vector dataset is a detailed (1-acre minimum), hierarchically organized vegetation cover map produced by computer classification of combined two-season pairs...

  1. Noncausal Bayesian Vector Autoregression

    DEFF Research Database (Denmark)

    Lanne, Markku; Luoto, Jani

    We propose a Bayesian inferential procedure for the noncausal vector autoregressive (VAR) model that is capable of capturing nonlinearities and incorporating effects of missing variables. In particular, we devise a fast and reliable posterior simulator that yields the predictive distribution...

  2. Understanding Vector Fields.

    Science.gov (United States)

    Curjel, C. R.

    1990-01-01

    Presented are activities that help students understand the idea of a vector field. Included are definitions, flow lines, tangential and normal components along curves, flux and work, field conservation, and differential equations. (KR)

  3. Tagged Vector Contour (TVC)

    Data.gov (United States)

    Kansas Data Access and Support Center — The Kansas Tagged Vector Contour (TVC) dataset consists of digitized contours from the 7.5 minute topographic quadrangle maps. Coverage for the state is incomplete....

  4. Implicit Real Vector Automata

    OpenAIRE

    Jean-François Degbomont; Julien Brusten; Bernard Boigelot

    2010-01-01

    This paper addresses the symbolic representation of non-convex real polyhedra, i.e., sets of real vectors satisfying arbitrary Boolean combinations of linear constraints. We develop an original data structure for representing such sets, based on an implicit and concise encoding of a known structure, the Real Vector Automaton. The resulting formalism provides a canonical representation of polyhedra, is closed under Boolean operators, and admits an efficient decision procedure for testing the ...

  5. Vector Lattice Vortex Solitons

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-Dong; YE Fang-Wei; DONG Liang-Wei; LI Yong-Ping

    2005-01-01

    @@ Two-dimensional vector vortex solitons in harmonic optical lattices are investigated. The stability properties of such solitons are closely connected to the lattice depth Vo. For small Vo, vector vortex solitons with the total zero-angular momentum are more stable than those with the total nonzero-angular momentum, while for large Vo, this case is inversed. If Vo is large enough, both the types of such solitons are stable.

  6. Support vector machines applications

    CERN Document Server

    Guo, Guodong

    2014-01-01

    Support vector machines (SVM) have both a solid mathematical background and good performance in practical applications. This book focuses on the recent advances and applications of the SVM in different areas, such as image processing, medical practice, computer vision, pattern recognition, machine learning, applied statistics, business intelligence, and artificial intelligence. The aim of this book is to create a comprehensive source on support vector machine applications, especially some recent advances.

  7. Vector financial rogue waves

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Zhenya, E-mail: zyyan@mmrc.iss.ac.cn [Key Laboratory of Mathematics Mechanization, Institute of Systems Science, AMSS, Chinese Academy of Sciences, Beijing 100190 (China)

    2011-11-21

    The coupled nonlinear volatility and option pricing model presented recently by Ivancevic is investigated, which generates a leverage effect, i.e., stock volatility is (negatively) correlated to stock returns, and can be regarded as a coupled nonlinear wave alternative of the Black–Scholes option pricing model. In this Letter, we analytically propose vector financial rogue waves of the coupled nonlinear volatility and option pricing model without an embedded w-learning. Moreover, we exhibit their dynamical behaviors for chosen different parameters. The vector financial rogue wave (rogon) solutions may be used to describe the possible physical mechanisms for the rogue wave phenomena and to further excite the possibility of relative researches and potential applications of vector rogue waves in the financial markets and other related fields. -- Highlights: ► We investigate the coupled nonlinear volatility and option pricing model. ► We analytically present vector financial rogue waves. ► The vector financial rogue waves may be used to describe the extreme events in financial markets. ► This results may excite the relative researches and potential applications of vector rogue waves.

  8. Vector financial rogue waves

    International Nuclear Information System (INIS)

    The coupled nonlinear volatility and option pricing model presented recently by Ivancevic is investigated, which generates a leverage effect, i.e., stock volatility is (negatively) correlated to stock returns, and can be regarded as a coupled nonlinear wave alternative of the Black–Scholes option pricing model. In this Letter, we analytically propose vector financial rogue waves of the coupled nonlinear volatility and option pricing model without an embedded w-learning. Moreover, we exhibit their dynamical behaviors for chosen different parameters. The vector financial rogue wave (rogon) solutions may be used to describe the possible physical mechanisms for the rogue wave phenomena and to further excite the possibility of relative researches and potential applications of vector rogue waves in the financial markets and other related fields. -- Highlights: ► We investigate the coupled nonlinear volatility and option pricing model. ► We analytically present vector financial rogue waves. ► The vector financial rogue waves may be used to describe the extreme events in financial markets. ► This results may excite the relative researches and potential applications of vector rogue waves.

  9. The Vector Curvaton

    CERN Document Server

    Navarro, Andres A

    2013-01-01

    We analyze a massive vector field with a non-canonical kinetic term in the action, minimally coupled to gravity, where the mass and kinetic function of the vector field vary as functions of time during inflation. The vector field is introduced following the same idea of a scalar curvaton, which must not affect the inflationary dynamics since its energy density during inflation is negligible compared to the total energy density in the Universe. Using this hypothesis, the vector curvaton will be solely responsible for generating the primordial curvature perturbation \\zeta. We have found that the spectra of the vector field perturbations are scale-invariant in superhorizon scales due to the suitable choice of the time dependence of the kinetic function and the effective mass during inflation. The preferred direction, generated by the vector field, makes the spectrum of \\zeta depend on the wavevector, i.e. there exists statistical anisotropy in \\zeta. This is discussed principally in the case where the mass of th...

  10. Extended Mixed Vector Equilibrium Problems

    Directory of Open Access Journals (Sweden)

    Mijanur Rahaman

    2014-01-01

    Full Text Available We study extended mixed vector equilibrium problems, namely, extended weak mixed vector equilibrium problem and extended strong mixed vector equilibrium problem in Hausdorff topological vector spaces. Using generalized KKM-Fan theorem (Ben-El-Mechaiekh et al.; 2005, some existence results for both problems are proved in noncompact domain.

  11. Vector WIMP Miracle

    CERN Document Server

    Abe, Tomohiro; Matsumoto, Shigeki; Seto, Osamu

    2012-01-01

    Weakly interacting massive particle (WIMP) is well known to be a good candidate for dark matter, and it is also predicted by many new physics models beyond the standard model at the TeV scale. We found that, if the WIMP is a vector particle (spin one particle) which is associated with some gauge symmetry broken at the TeV scale, the higgs mass is often predicted to be 120--125 GeV, which is very consistent with the result of higgs searches recently reported by ATLAS and CMS collaborations at the Large Hadron Collider experiment. In this letter, we consider the vector WIMP using a non-linear sigma model in order to confirm this result as general as possible in a bottom-up approach. Near-future prospects to detect the vector WIMP at both direct and indirect detection experiments of dark matter are also discussed.

  12. Vector financial rogue waves

    Science.gov (United States)

    Yan, Zhenya

    2011-11-01

    The coupled nonlinear volatility and option pricing model presented recently by Ivancevic is investigated, which generates a leverage effect, i.e., stock volatility is (negatively) correlated to stock returns, and can be regarded as a coupled nonlinear wave alternative of the Black-Scholes option pricing model. In this Letter, we analytically propose vector financial rogue waves of the coupled nonlinear volatility and option pricing model without an embedded w-learning. Moreover, we exhibit their dynamical behaviors for chosen different parameters. The vector financial rogue wave (rogon) solutions may be used to describe the possible physical mechanisms for the rogue wave phenomena and to further excite the possibility of relative researches and potential applications of vector rogue waves in the financial markets and other related fields.

  13. Vector WIMP miracle

    Science.gov (United States)

    Abe, Tomohiro; Kakizaki, Mitsuru; Matsumoto, Shigeki; Seto, Osamu

    2012-07-01

    Weakly interacting massive particle (WIMP) is well known to be a good candidate for dark matter, and it is also predicted by many new physics models beyond the standard model at the TeV scale. We found that, if the WIMP is a vector particle (spin-one particle) which is associated with some gauge symmetry broken at the TeV scale, the Higgs mass is often predicted to be 120-125 GeV, which is very consistent with the result of Higgs searches recently reported by ATLAS and CMS Collaborations at the Large Hadron Collider experiment. In this Letter, we consider the vector WIMP using a non-linear sigma model in order to confirm this result as general as possible in a bottom-up approach. Near-future prospects to detect the vector WIMP at both direct and indirect detection experiments of dark matter are also discussed.

  14. Boosting Support Vector Machines

    Directory of Open Access Journals (Sweden)

    Elkin Eduardo García Díaz

    2006-11-01

    Full Text Available En este artículo, se presenta un algoritmo de clasificación binaria basado en Support Vector Machines (Máquinas de Vectores de Soporte que combinado apropiadamente con técnicas de Boosting consigue un mejor desempeño en cuanto a tiempo de entrenamiento y conserva características similares de generalización con un modelo de igual complejidad pero de representación más compacta./ In this paper we present an algorithm of binary classification based on Support Vector Machines. It is combined with a modified Boosting algorithm. It run faster than the original SVM algorithm with a similar generalization error and equal complexity model but it has more compact representation.

  15. HLA-C和HLA-G基因真核细胞双表达载体的克隆及鉴定分析%Clone and identification of the eukaryotic co-expression vector of human HLA-G and HLA-C genes with bicistronic vector pVITRO2

    Institute of Scientific and Technical Information of China (English)

    张磊; 杨珏琴; 姚芳娟; 许玲娣; 范丽安

    2004-01-01

    目的构建人HLA-C和HLA-G基因真核细胞双表达载体.方法用RT-PCR从孕妇蜕膜组织有核细胞总mRNA中逆转录扩增全长HLA-C和HLA-G cDNA,首先将HLA-G经BamHⅠ和Cla Ⅰ双酶切,HLA-C经EcoRⅠ和Xho Ⅰ双酶切后,分别定向插入真核细胞双顺反子载体pVITRO2的多克隆位点1(mcs1)和2(mcs2)中,然后经酶切和测序鉴定,确定已建立pVITRO2的单表达质粒pVITRO2-HLA-G和pVITRO2-HLA-C,再将HLA-C cDNA经EcoRⅠ和Xho Ⅰ双酶切,定向插入单表达质粒pVITRO2-HLA-G的多克隆位点2(mcs2)中,经PCR反应初筛,再经双酶切鉴定.结果限制性内切酶和测序分析表明已成功构建了HLA-Cw*0103和HLA-G*0101的单表达质粒pVITRO2-HLA-C和pVITRO2-HLA-G以及双表达质粒pVITRO2-HLA-CG.结论本研究成功构建了真核细胞双顺反子载体pVITRO2的双表达质粒pVITRO2-HLA-CG,以及单表达质粒pVITRO2-HLA-C和pVITRO2-HLA-G.

  16. Matrix vector analysis

    CERN Document Server

    Eisenman, Richard L

    2005-01-01

    This outstanding text and reference applies matrix ideas to vector methods, using physical ideas to illustrate and motivate mathematical concepts but employing a mathematical continuity of development rather than a physical approach. The author, who taught at the U.S. Air Force Academy, dispenses with the artificial barrier between vectors and matrices--and more generally, between pure and applied mathematics.Motivated examples introduce each idea, with interpretations of physical, algebraic, and geometric contexts, in addition to generalizations to theorems that reflect the essential structur

  17. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...

  18. Scalar-Vector Bootstrap

    CERN Document Server

    Rejon-Barrera, Fernando

    2015-01-01

    We work out all of the details required for implementation of the conformal bootstrap program applied to the four-point function of two scalars and two vectors in an abstract conformal field theory in arbitrary dimension. This includes a review of which tensor structures make appearances, a construction of the projectors onto the required mixed symmetry representations, and a computation of the conformal blocks for all possible operators which can be exchanged. These blocks are presented as differential operators acting upon the previously known scalar conformal blocks. Finally, we set up the bootstrap equations which implement crossing symmetry. Special attention is given to the case of conserved vectors, where several simplifications occur.

  19. Analysis in Vector Spaces

    CERN Document Server

    Akcoglu, Mustafa A; Ha, Dzung Minh

    2011-01-01

    A rigorous introduction to calculus in vector spaces The concepts and theorems of advanced calculus combined with related computational methods are essential to understanding nearly all areas of quantitative science. Analysis in Vector Spaces presents the central results of this classic subject through rigorous arguments, discussions, and examples. The book aims to cultivate not only knowledge of the major theoretical results, but also the geometric intuition needed for both mathematical problem-solving and modeling in the formal sciences. The authors begin with an outline of key concepts, ter

  20. Vector-borne Infections

    Centers for Disease Control (CDC) Podcasts

    2011-04-18

    This podcast discusses emerging vector-borne pathogens, their role as prominent contributors to emerging infectious diseases, how they're spread, and the ineffectiveness of mosquito control methods.  Created: 4/18/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/27/2011.

  1. Singular Vectors' Subtle Secrets

    Science.gov (United States)

    James, David; Lachance, Michael; Remski, Joan

    2011-01-01

    Social scientists use adjacency tables to discover influence networks within and among groups. Building on work by Moler and Morrison, we use ordered pairs from the components of the first and second singular vectors of adjacency matrices as tools to distinguish these groups and to identify particularly strong or weak individuals.

  2. Vector-borne diseases.

    Science.gov (United States)

    Gubler, D J

    2009-08-01

    Vector-borne diseases have been the scourge of man and animals since the beginning of time. Historically, these are the diseases that caused the great plagues such as the 'Black Death' in Europe in the 14th Century and the epidemics of yellow fever that plagued the development of the New World. Others, such as Nagana, contributed to the lack of development in Africa for many years. At the turn of the 20th Century, vector-borne diseases were among the most serious public and animal health problems in the world. For the most part, these diseases were controlled by the middle of the 20th Century through the application of knowledge about their natural history along with the judicious use of DDT (dichlorodiphenyltrichloroethane) and other residual insecticides to interrupt the transmission cycle between arthropod and vertebrate host. However, this success initiated a period of complacency in the 1960s and 1970s, which resulted in the redirection of resources away from prevention and control of vector-borne diseases. The 1970s was also a time in which there were major changes to public health policy. Global trends, combined with changes in animal husbandry, urbanisation, modern transportation and globalisation, have resulted in a global re-emergence of epidemic vector-borne diseases affecting both humans and animals over the past 30 years. PMID:20128467

  3. Calculus with vectors

    CERN Document Server

    Treiman, Jay S

    2014-01-01

    Calculus with Vectors grew out of a strong need for a beginning calculus textbook for undergraduates who intend to pursue careers in STEM. fields. The approach introduces vector-valued functions from the start, emphasizing the connections between one-variable and multi-variable calculus. The text includes early vectors and early transcendentals and includes a rigorous but informal approach to vectors. Examples and focused applications are well presented along with an abundance of motivating exercises. All three-dimensional graphs have rotatable versions included as extra source materials and may be freely downloaded and manipulated with Maple Player; a free Maple Player App is available for the iPad on iTunes. The approaches taken to topics such as the derivation of the derivatives of sine and cosine, the approach to limits, and the use of "tables" of integration have been modified from the standards seen in other textbooks in order to maximize the ease with which students may comprehend the material. Additio...

  4. Vector independent transmission of the vector-borne bluetongue virus

    NARCIS (Netherlands)

    Sluijs, van der M.T.W.; Smit, de A.J.; Moormann, R.J.M.

    2015-01-01

    Bluetongue is an economically important disease of ruminants. The causative agent, Bluetongue virus (BTV), is mainly transmitted by insect vectors. This review focuses on vector-free BTV transmission, and its epizootic and economic consequences. Vector-free transmission can either be vertical, from

  5. VECTOR BUNDLE, KILLING VECTOR FIELD AND PONTRYAGIN NUMBERS

    Institute of Scientific and Technical Information of China (English)

    周建伟

    1991-01-01

    Let E be a vector bundle over a compact Riemannian manifold M. We construct a natural metric on the bundle space E and discuss the relationship between the killing vector fields of E and M. Then we give a proof of the Bott-Baum-Cheeger Theorem for vector bundle E.

  6. Vector grammars and PN machines

    Institute of Scientific and Technical Information of China (English)

    蒋昌俊

    1996-01-01

    The concept of vector grammars under the string semantic is introduced.The dass of vector grammars is given,which is similar to the dass of Chomsky grammars.The regular vector grammar is divided further.The strong and weak relation between the vector grammar and scalar grammar is discussed,so the spectrum system graph of scalar and vector grammars is made.The equivalent relation between the regular vector grammar and Petri nets (also called PN machine) is pointed.The hybrid PN machine is introduced,and its language is proved equivalent to the language of the context-free vector grammar.So the perfect relation structure between vector grammars and PN machines is formed.

  7. On Generalized Vector Equilibrium Problems

    Institute of Scientific and Technical Information of China (English)

    An-hua Wan; Jun-yi Fu; Wei-hua Mao

    2006-01-01

    A new generalized vector equilibrium problem involving set-valued mappings and the proper quasi-concavity of set-valued mappings in topological vector spaces are introduced; its existence theorems and the convexity of the solution sets are established.

  8. Bloch vectors for qudits

    Energy Technology Data Exchange (ETDEWEB)

    Bertlmann, Reinhold A; Krammer, Philipp [Faculty of Physics, University of Vienna, Boltzmanngasse 5, A-1090 Vienna (Austria)], E-mail: reinhold.bertlmann@univie.ac.at, E-mail: philipp.krammer@univie.ac.at

    2008-06-13

    We present three different matrix bases that can be used to decompose density matrices of d-dimensional quantum systems, so-called qudits: the generalized Gell-Mann matrix basis, the polarization operator basis and the Weyl operator basis. Such a decomposition can be identified with a vector-the Bloch vector, i.e. a generalization of the well-known qubit case-and is a convenient expression for comparison with measurable quantities and for explicit calculations avoiding the handling of large matrices. We present a new method to decompose density matrices via so-called standard matrices, consider the important case of an isotropic two-qudit state and decompose it according to each basis. In the case of qutrits we show a representation of an entanglement witness in terms of expectation values of spin-1 measurements, which is appropriate for an experimental realization.

  9. Vector mesons in matter

    Indian Academy of Sciences (India)

    Gy Wolf

    2006-04-01

    One consequence of the chiral restoration is the mixing of parity partners. We look for a possible signature of the mixing of vector and axial vector mesons in heavy-ion collisions. We suggest an experimental method for its observation. The dynamical evolution of the heavy-ion collision is described by a transport equation of QMD-type evolving nucleons, * and resonances, ’s and $\\sum$ baryons, and furthermore, ’s, ’s ’s ’s ’s and kaons with their isospin degrees of freedom. The input cross-sections and resonance parameters of the model are fitted to the available nucleon–nucleon and pion–nucleon cross-sections.

  10. Engineering influenza viral vectors

    OpenAIRE

    Li, Junwei; Arévalo, Maria T; Zeng, Mingtao

    2013-01-01

    The influenza virus is a respiratory pathogen with a negative-sense, segmented RNA genome. Construction of recombinant influenza viruses in the laboratory was reported starting in the 1980s. Within a short period of time, pioneer researchers had devised methods that made it possible to construct influenza viral vectors from cDNA plasmid systems. Herein, we discuss the evolution of influenza virus reverse genetics, from helper virus-dependent systems, to helper virus-independent 17-plasmid sys...

  11. Helices and vector bundles

    CERN Document Server

    Rudakov, A N

    1990-01-01

    This volume is devoted to the use of helices as a method for studying exceptional vector bundles, an important and natural concept in algebraic geometry. The work arises out of a series of seminars organised in Moscow by A. N. Rudakov. The first article sets up the general machinery, and later ones explore its use in various contexts. As to be expected, the approach is concrete; the theory is considered for quadrics, ruled surfaces, K3 surfaces and P3(C).

  12. Japanese Encephalitis Vectors

    OpenAIRE

    Wada, Yoshito

    1995-01-01

    On the ecological basis of vector mosquitoes of Japanese encephalitis, measures of their control were examined from viewpoint of their practicability. It was concluded that chemical control is not of practical value, biological control is of limited effectiveness, and environmental control by source reduction is impossible. Instead, it was recommended to improve human living style so as to reduce the frequency of man/mosquito contact.

  13. Interpolation of Vector Measures

    Institute of Scientific and Technical Information of China (English)

    Ricardo del CAMPO; Antonio FERN(A)NDEZ; Fernando MAYORAL; Francisco NARANJO; Enrique A. S(A)NCHEZ-P(E)REZ

    2011-01-01

    Let (Ω, ∑) be a measurable space and m0: ∑→ X0 and m1: ∑ -→ X1 be positive vector measures with values in the Banach K(o)the function spaces X0 and X1. If 0 < α < 1, we define a X10-αXα1 and we analyze the space of integrable functions with respect to measure [m0, m1]α in order to prove suitable extensions of the classical Stein-Weiss formulas that hold for the complex interpolation of Lp-spaces.Since each p-convex order continuous K(o)the function space with weak order unit can be represented as a space of p-integrable functions with respect to a vector measure, we provide in this way a technique to obtain representations of the corresponding complex interpolation spaces. As applications, we provide a Riesz-Thorin theorem for spaces of p-integrable functions with respect to vector measures and a formula for representing the interpolation of the injective tensor product of such spaces.

  14. Scalar - vector soliton fiber lasers

    CERN Document Server

    Wu, Zhichao; Li, Lei; Luo, Yiyang; Tang, Dingyuan; Shen, Deyuan; Tang, Ming; Fu, Songnian; Zhao, Luming

    2016-01-01

    Rapid progress in passively mode-locked fiber lasers is currently driven by the recent discovery of vector feature of mode-locking pulses, namely, the group velocity-locked vector solitons, the phase locked vector solitons, and the high-order vector solitons. Those vector solitons are fundamentally different from the previously known scalar solitons. Here, we report a fiber laser where the mode-locked pulse evolves as a vector soliton in the strong birefringent segment and is transformed into a regular scalar soliton after the polarizer within the laser cavity. The existence of solutions in a polarization-dependent cavity comprising a periodic combination of two distinct nonlinear waves is novel and likely to be applicable to various other nonlinear systems. For very large local birefringence, our laser approaches the working regime of vector soliton lasers, while it approaches scalar soliton fiber lasers under the conditions of very small birefringence.

  15. Relativistic Rotating Vector Model

    CERN Document Server

    Lyutikov, Maxim

    2016-01-01

    The direction of polarization produced by a moving source rotates with the respect to the rest frame. We show that this effect, induced by pulsar rotation, leads to an important correction to polarization swings within the framework of rotating vector model (RVM); this effect has been missed by previous works. We construct relativistic RVM taking into account finite heights of the emission region that lead to aberration, time-of-travel effects and relativistic rotation of polarization. Polarizations swings at different frequencies can be used, within the assumption of the radius-to-frequency mapping, to infer emission radii and geometry of pulsars.

  16. Extended vector-tensor theories

    CERN Document Server

    Kimura, Rampei; Yoshida, Daisuke

    2016-01-01

    Recently, several extensions of massive vector theory in curved space-time have been proposed in many literatures. In this paper, we consider the most general vector-tensor theories that contain up to two derivatives with respect to metric and vector field. By imposing a degeneracy condition of the Lagrangian in the context of ADM decomposition of space-time to eliminate an unwanted mode, we construct a new class of massive vector theories where five degrees of freedom can propagate, corresponding to three for massive vector modes and two for massless tensor modes. We find that the generalized Proca and the beyond generalized Proca theories up to the quartic Lagrangian, which should be included in this formulation, are degenerate theories even in curved space-time. Finally, introducing new metric and vector field transformations, we investigate the properties of thus obtained theories under such transformations.

  17. Semitopological Vector Spaces and Hyperseminorms

    Directory of Open Access Journals (Sweden)

    Mark Burgin

    2013-11-01

    Full Text Available In this paper, we introduce and study semitopological vector spaces. The goal is to provide an efficient base for developing the theory of extrafunction spaces in an abstract setting of algebraic systems and topological spaces. Semitopological vector spaces are more general than conventional topological vector spaces, which proved to be very useful for solving many problems in functional analysis. To study semitopological vector spaces, hypermetrics and hyperpseudometrics are introduced and it is demonstrated that hyperseminorms, studied in previous works of the author, induce hyperpseudometrics, while hypernorms induce hypermetrics. Sufficient and necessary conditions for a hyperpseudometric (hypermetric to be induced by a hyperseminorm (hypernorm are found. We also show that semitopological vector spaces are closely related to systems of hyperseminorms. Then defining boundedness and continuity relative to associated systems of hyperseminorms, we study relations between relative boundedness and relative continuity for mappings of vector spaces with systems of hyperseminorms and systems of hypernorms.

  18. Optimality Conditions in Vector Optimization

    CERN Document Server

    Jiménez, Manuel Arana; Lizana, Antonio Rufián

    2011-01-01

    Vector optimization is continuously needed in several science fields, particularly in economy, business, engineering, physics and mathematics. The evolution of these fields depends, in part, on the improvements in vector optimization in mathematical programming. The aim of this Ebook is to present the latest developments in vector optimization. The contributions have been written by some of the most eminent researchers in this field of mathematical programming. The Ebook is considered essential for researchers and students in this field.

  19. Multiscale hierarchical support vector clustering

    Science.gov (United States)

    Hansen, Michael Saas; Holm, David Alberg; Sjöstrand, Karl; Ley, Carsten Dan; Rowland, Ian John; Larsen, Rasmus

    2008-03-01

    Clustering is the preferred choice of method in many applications, and support vector clustering (SVC) has proven efficient for clustering noisy and high-dimensional data sets. A method for multiscale support vector clustering is demonstrated, using the recently emerged method for fast calculation of the entire regularization path of the support vector domain description. The method is illustrated on artificially generated examples, and applied for detecting blood vessels from high resolution time series of magnetic resonance imaging data. The obtained results are robust while the need for parameter estimation is reduced, compared to support vector clustering.

  20. Multistage vector (MSV) therapeutics.

    Science.gov (United States)

    Wolfram, Joy; Shen, Haifa; Ferrari, Mauro

    2015-12-10

    One of the greatest challenges in the field of medicine is obtaining controlled distribution of systemically administered therapeutic agents within the body. Indeed, biological barriers such as physical compartmentalization, pressure gradients, and excretion pathways adversely affect localized delivery of drugs to pathological tissue. The diverse nature of these barriers requires the use of multifunctional drug delivery vehicles that can overcome a wide range of sequential obstacles. In this review, we explore the role of multifunctionality in nanomedicine by primarily focusing on multistage vectors (MSVs). The MSV is an example of a promising therapeutic platform that incorporates several components, including a microparticle, nanoparticles, and small molecules. In particular, these components are activated in a sequential manner in order to successively address transport barriers. PMID:26264836

  1. Estimation of vector velocity

    DEFF Research Database (Denmark)

    2000-01-01

    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...... estimator automatically compensates for the axial velocity, when determining the transverse velocity by using fourth order moments rather than second order moments. The estimation is optimized by using a lag different from one in the estimation process, and noise artifacts are reduced by using averaging...... of RF samples. Further, compensation for the axial velocity can be introduced, and the velocity estimation is done at a fixed depth in tissue to reduce spatial velocity dispersion....

  2. Vector-Tensor and Vector-Vector Decay Amplitude Analysis of B0->phi K*0

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, R; Allen, M T; Allison, J; Altenburg, D D; Andreotti, M; Angelini, C; Anulli, F; Arnaud, N; Asgeirsson, D J; Aston, D; Azzolini, V; Baak, M A; Back, J J; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Bechtle, P; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Benelli, G; Berger, N; Bernard, D; Berryhill, J W; Best, D S; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bhuyan, B; Bianchi, F; Biasini, M; Biesiada, J; Blanc, F; Blaylock, G; Blinov, V E; Bloom, P C; Blount, N L; Bomben, M; Bondioli, M; Bonneaud, G R; Bosisio, L; Boutigny, D; Bowerman, D A; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Briand, H; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Bugg, W; Bukin, A D; Bula, R; Burchat, P R; Burke, J P; Button-Shafer, J; Buzzo, A; Bóna, M; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Cenci, R; Chai, X; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, C; Chen, E; Chen, J C; Chen, S; Chen, X; Chen, X R; Cheng, B; Cheng, C H; Chia, Y M; Cibinetto, G; Clark, P J; Clarke, C K; Claus, R; Cochran, J; Coleman, J P; Contri, R; Convery, M R; Corwin, L A; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L; Cunha, A; Curry, S; Côté, D; D'Orazio, A; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; De Nardo, Gallieno; De Sangro, R; Del Amo-Sánchez, P; Del Buono, L; Del Re, D; Della Ricca, G; Denig, A G; Di Lodovico, F; Di Marco, E; Dingfelder, J C; Dittongo, S; Dong, L; Dorfan, J; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Ebert, M; Eckhart, E A; Eckmann, R; Edgar, C L; Edwards, A J; Egede, U; Eigen, G; Eisner, A M; Elmer, P; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Eyges, V; Fabozzi, F; Faccini, R; Fang, F; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flacco, C J; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B; Frey, R; Fritsch, M; Fry, J R; Fulsom, B G; Gabathuler, E; Gaidot, A; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gao, Y; Gary, J W; Gaspero, M; Gatto, C; Gaz, A; George, K A; Gill, M S; Giorgi, M A; Gladney, L; Glanzman, T; Godang, R; Golubev, V B; Gowdy, S J; Gradl, W; Graham, M T; Graugès-Pous, E; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Z J; Hadavand, H K; Haire, M; Halyo, V; Hamano, K; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hartfiel, B L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hill, E J; Hirschauer, J F; Hitlin, D G; Hollar, J J; Hong, T M; Honscheid, K; Hopkins, D A; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Höcker, A; Igonkina, O; Innes, W R; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jain, V; Jasper, H; Jawahery, A; Jessop, C P; Judd, D; Kadyk, J A; Kagan, H; Karyotakis, Yu; Kass, R; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Klose, V; Knecht, N S; Koch, H; Kolb, J A; Kolomensky, Yu G; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kreisel, A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; La Vaissière, C de; Lacker, H M; Lae, C K; Lafferty, G D; Lanceri, L; Lange, D J; Lankford, A J; Latham, T E; Latour, E; Lau, Y P; Lazzaro, A; Le Diberder, F R; Lee, C L; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, S; Li, X; Lista, L; Liu, H; Lo Vetere, M; LoSecco, J M; Lockman, W S; Lombardo, V; Long, O; Lopes-Pegna, D; Lopez-March, N; Lou, X C; Lu, M; Luitz, S; Lund, P; Luppi, E; Lusiani, A; Lutz, A M; Lynch, G; Lynch, H L; Lü, C; Lüth, V; MacFarlane, D B; Macri, M M; Mader, W F; Majewski, S A; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Marchiori, G; Margoni, M; Marks, J; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Mclachlin, S E; Meadows, B T; Mellado, B; Menges, W; Merkel, J; Messner, R; Meyer, N T; Meyer, W T; Mihályi, A; Mir, L M; Mishra, K; Mohanty, G B; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morganti, M; Morganti, S; Morii, M; Muheim, F; Müller, D R; Nagel, M; Naisbit, M T; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; Nugent, I M; O'Grady, C P; Ocariz, J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Oyanguren, A; Ozcan, V E; Paar, H P; Pacetti, S; Palano, A; Palombo, F; Pan, B; Pan, Y; Panduro, W; Paoloni, E; Paolucci, P; Pappagallo, M; Park, W; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Peters, K; Petersen, B A; Petrella, A; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Piredda, G; Playfer, S; Poireau, V; Polci, F; Pompili, A; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prencipe, E; Prepost, R; Pripstein, M; Pruvot, S; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rahmat, R; Rama, M; Ratcliff, B N; Raven, G; Regensburger, J J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roberts, D A; Robertson, A I; Robertson, S H; Robutti, E; Rodier, S; Roe, N A; Ronan, M T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Roudeau, P; Rubin, A E; Ruddick, W O; Röthel, W; Sacco, R; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Sanders, D A; Santroni, A; Saremi, S; Satpathy, A; Schalk, T; Schenk, S; Schilling, C J; Schindler, R H; Schofield, K C; Schott, G; Schröder, T; Schröder, H; Schubert, J; Schubert, K R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Serrano, J; Sharma, V; Shen, B C; Sherwood, D J; Simard, M; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spitznagel, M; Spradlin, P; Steinke, M; Stelzer, J; Stocchi, A; Stoker, D P; Stroili, R; Strom, D; Strube, J; Stugu, B; Stängle, H; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; Suzuki, K; Swain, S K; Taras, P; Taylor, F; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thompson, J M; Tisserand, V; Todyshev, Y K; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Ulmer, K A; Uwer, U; Van Bakel, N; Vasseur, G; Vavra, J; Vazquez, A; Verderi, M; Viaud, F B; Vitale, L; Voci, C; Voena, C; Volk, A; Wagner, A P; Wagner, S R; Wagoner, D E; Waldi, R; Walker, D; Walsh, J J; Wang, K; Wang, P; Wang, W F; Wappler, F R; Watson, A T; Weaver, M; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winklmeier, F; Wisniewski, W J; Wittgen, M; Wong, Q K; Wormser, G; Wren, A C; Wright, D H; Wright, D M; Wu, J; Wu, S L; Wulsin, H W; Xie, Y; Yamamoto, R K; Yarritu, A K; Ye, S; Yi, J I; Yi, K; Young, C C; Yu, Z; Yéche, C; Zain, S B; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Ziegler, V; Zito, M; Çuhadar-Dönszelmann, T; al, et

    2007-01-01

    We perform an amplitude analysis of the decays B0->phi K^*_2(1430)0, phi K^*(892)0, and phi(K pi)^0_S-wave with a sample of about 384 million BBbar pairs recorded with the BABAR detector. The fractions of longitudinal polarization f_L of the vector-tensor and vector-vector decay modes are measured to be 0.853 +0.061-0.069 +-0.036 and 0.506 +-0.040 +-0.015, respectively. Overall, twelve parameters are measured for the vector-vector decay and seven parameters for the vector-tensor decay, including the branching fractions and parameters sensitive to CP-violation.

  3. Testing identifiablility of cointegrating vectors

    NARCIS (Netherlands)

    H.P. Boswijk

    1996-01-01

    This article analyzes the identification and normalization of cointegrating vectors. Normalizing a cointegrating relation with respect to one of the relevant variables is with loss of generality; and restrictions that are supposed to identify a vector may fail to do so for particular parameter value

  4. Estimation of Motion Vector Fields

    DEFF Research Database (Denmark)

    Larsen, Rasmus

    1993-01-01

    This paper presents an approach to the estimation of 2-D motion vector fields from time varying image sequences. We use a piecewise smooth model based on coupled vector/binary Markov random fields. We find the maximum a posteriori solution by simulated annealing. The algorithm generate sample...

  5. Vectors on the Basketball Court

    Science.gov (United States)

    Bergman, Daniel

    2010-01-01

    An Idea Bank published in the April/May 2009 issue of "The Science Teacher" describes an experiential physics lesson on vectors and vector addition (Brown 2009). Like its football predecessor, the basketball-based investigation presented in this Idea Bank addresses National Science Education Standards Content B, Physical Science, 9-12 (NRC 1996)…

  6. Rice Reoviruses in Insect Vectors.

    Science.gov (United States)

    Wei, Taiyun; Li, Yi

    2016-08-01

    Rice reoviruses, transmitted by leafhopper or planthopper vectors in a persistent propagative manner, seriously threaten the stability of rice production in Asia. Understanding the mechanisms that enable viral transmission by insect vectors is a key to controlling these viral diseases. This review describes current understanding of replication cycles of rice reoviruses in vector cell lines, transmission barriers, and molecular determinants of vector competence and persistent infection. Despite recent breakthroughs, such as the discoveries of actin-based tubule motility exploited by viruses to overcome transmission barriers and mutually beneficial relationships between viruses and bacterial symbionts, there are still many gaps in our knowledge of transmission mechanisms. Advances in genome sequencing, reverse genetics systems, and molecular technologies will help to address these problems. Investigating the multiple interaction systems among the virus, insect vector, insect symbiont, and plant during natural infection in the field is a central topic for future research on rice reoviruses. PMID:27296147

  7. Octonionic Reformulation of Vector Analysis

    CERN Document Server

    Chauhan, Bhupendra C S; Negi, O P S

    2010-01-01

    According to celebrated Hurwitz theorem, there exists four division algebras consisting of R (real numbers), C (complex numbers), H (quaternions) and O (octonions). Keeping in view the utility of octonion variable we have tried to extend the three dimensional vector analysis to seven dimensional one. Starting with the scalar and vector product in seven dimensions, we have redefined the gradient, divergence and curl in seven dimension. It is shown that the identity n(n-1)(n-3)(n-7)=0 is satisfied only for 0, 1, 3 and 7 dimensional vectors. We have tried to write all the vector inequalities and formulas in terms of seven dimensions and it is shown that same formulas loose their meaning in seven dimensions due to non-associativity of octonions. The vector formulas are retained only if we put certain restrictions on octonions and split octonions.

  8. Emerging vector borne diseases – incidence through vectors

    Directory of Open Access Journals (Sweden)

    Sara eSavic

    2014-12-01

    Full Text Available Vector borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowdays, in intercontinetal countries, there is a struggle with emerging diseases which have found their way to appear through vectors. Vector borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector borne infectious diseases and disease outbreaks. It could affect the range and popultion of pathogens, host and vectors, transmission season, etc. Reliable surveilance for diseases that are most likely to emerge is required. Canine vector borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, erlichiosis, leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fudamental role at primeraly prevention and then treatment of vector borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases.During a four year period, from 2009-2013, a total number of 551 dog samples were analysed for vector borne diseases (borreliosis, babesiosis, erlichiosis, anaplasmosis, dirofilariosis and leishmaniasis in routine laboratory work. The analysis were done by serological tests – ELISA for borreliosis, dirofilariosis and leishmaniasis, modified Knott test for dirofilariosis and blood smear for babesiosis, erlichiosis and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on avarege more then half of the samples

  9. Stable piecewise polynomial vector fields

    Directory of Open Access Journals (Sweden)

    Claudio Pessoa

    2012-09-01

    Full Text Available Let $N={y>0}$ and $S={y<0}$ be the semi-planes of $mathbb{R}^2$ having as common boundary the line $D={y=0}$. Let $X$ and $Y$ be polynomial vector fields defined in $N$ and $S$, respectively, leading to a discontinuous piecewise polynomial vector field $Z=(X,Y$. This work pursues the stability and the transition analysis of solutions of $Z$ between $N$ and $S$, started by Filippov (1988 and Kozlova (1984 and reformulated by Sotomayor-Teixeira (1995 in terms of the regularization method. This method consists in analyzing a one parameter family of continuous vector fields $Z_{epsilon}$, defined by averaging $X$ and $Y$. This family approaches $Z$ when the parameter goes to zero. The results of Sotomayor-Teixeira and Sotomayor-Machado (2002 providing conditions on $(X,Y$ for the regularized vector fields to be structurally stable on planar compact connected regions are extended to discontinuous piecewise polynomial vector fields on $mathbb{R}^2$. Pertinent genericity results for vector fields satisfying the above stability conditions are also extended to the present case. A procedure for the study of discontinuous piecewise vector fields at infinity through a compactification is proposed here.

  10. Chikungunya Virus–Vector Interactions

    Directory of Open Access Journals (Sweden)

    Lark L. Coffey

    2014-11-01

    Full Text Available Chikungunya virus (CHIKV is a mosquito-borne alphavirus that causes chikungunya fever, a severe, debilitating disease that often produces chronic arthralgia. Since 2004, CHIKV has emerged in Africa, Indian Ocean islands, Asia, Europe, and the Americas, causing millions of human infections. Central to understanding CHIKV emergence is knowledge of the natural ecology of transmission and vector infection dynamics. This review presents current understanding of CHIKV infection dynamics in mosquito vectors and its relationship to human disease emergence. The following topics are reviewed: CHIKV infection and vector life history traits including transmission cycles, genetic origins, distribution, emergence and spread, dispersal, vector competence, vector immunity and microbial interactions, and co-infection by CHIKV and other arboviruses. The genetics of vector susceptibility and host range changes, population heterogeneity and selection for the fittest viral genomes, dual host cycling and its impact on CHIKV adaptation, viral bottlenecks and intrahost diversity, and adaptive constraints on CHIKV evolution are also discussed. The potential for CHIKV re-emergence and expansion into new areas and prospects for prevention via vector control are also briefly reviewed.

  11. On the Witt vector Frobenius

    DEFF Research Database (Denmark)

    Davis, Christopher James; Kedlaya, Kiran

    2014-01-01

    We study the kernel and cokernel of the Frobenius map on the p-typical Witt vectors of a commutative ring, not necessarily of characteristic p. We give many equivalent conditions to surjectivity of the Frobenius map on both finite and infinite length Witt vectors. In particular, surjectivity...... on finite Witt vectors turns out to be stable under certain integral extensions; this provides a clean formulation of a strong generalization of Faltings’s almost purity theorem from p-adic Hodge theory, incorporating recent improvements by Kedlaya–Liu and by Scholze....

  12. Vector control of induction machines

    CERN Document Server

    Robyns, Benoit

    2012-01-01

    After a brief introduction to the main law of physics and fundamental concepts inherent in electromechanical conversion, ""Vector Control of Induction Machines"" introduces the standard mathematical models for induction machines - whichever rotor technology is used - as well as several squirrel-cage induction machine vector-control strategies. The use of causal ordering graphs allows systematization of the design stage, as well as standardization of the structure of control devices. ""Vector Control of Induction Machines"" suggests a unique approach aimed at reducing parameter sensitivity for

  13. All optical vector magnetometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I research project will investigate a novel method of operating an atomic magnetometer to simultaneously measure total magnetic fields and vector...

  14. Introduction to matrices and vectors

    CERN Document Server

    Schwartz, Jacob T

    2001-01-01

    In this concise undergraduate text, the first three chapters present the basics of matrices - in later chapters the author shows how to use vectors and matrices to solve systems of linear equations. 1961 edition.

  15. Acoustic vector sensor signal processing

    Institute of Scientific and Technical Information of China (English)

    SUN Guiqing; LI Qihu; ZHANG Bin

    2006-01-01

    Acoustic vector sensor simultaneously, colocately and directly measures orthogonal components of particle velocity as well as pressure at single point in acoustic field so that is possible to improve performance of traditional underwater acoustic measurement devices or detection systems and extends new ideas for solving practical underwater acoustic engineering problems. Although acoustic vector sensor history of appearing in underwater acoustic area is no long, but with huge and potential military demands, acoustic vector sensor has strong development trend in last decade, it is evolving into a one of important underwater acoustic technology. Under this background, we try to review recent progress in study on acoustic vector sensor signal processing, such as signal detection, DOA estimation, beamforming, and so on.

  16. Transcriptional Silencing of Retroviral Vectors

    DEFF Research Database (Denmark)

    Lund, Anders Henrik; Duch, M.; Pedersen, F.S.

    1996-01-01

    . Extinction of long-term vector expression has been observed after implantation of transduced hematopoietic cells as well as fibroblasts, myoblasts and hepatocytes. Here we review the influence of vector structure, integration site and cell type on transcriptional silencing. While down-regulation of proviral...... transcription is known from a number of cellular and animal models, major insight has been gained from studies in the germ line and embryonal cells of the mouse. Key elements for the transfer and expression of retroviral vectors, such as the viral transcriptional enhancer and the binding site for the t......RNA primer for reverse transcription may have a major influence on transcriptional silencing. Alterations of these elements of the vector backbone as well as the use of internal promoter elements from housekeeping genes may contribute to reduce transcriptional silencing. The use of cell culture and animal...

  17. Unsupervised learning of binary vectors

    Science.gov (United States)

    Copelli Lopes da Silva, Mauro

    In this thesis, unsupervised learning of binary vectors from data is studied using methods from Statistical Mechanics of disordered systems. In the model, data vectors are distributed according to a single symmetry-breaking direction. The aim of unsupervised learning is to provide a good approximation to this direction. The difference with respect to previous studies is the knowledge that this preferential direction has binary components. It is shown that sampling from the posterior distribution (Gibbs learning) leads, for general smooth distributions, to an exponentially fast approach to perfect learning in the asymptotic limit of large number of examples. If the distribution is non-smooth, then first order phase transitions to perfect learning are expected. In the limit of poor performance, a second order phase transition ("retarded learning") is predicted to occur if the data distribution is not biased. Using concepts from Bayesian inference, the center of mass of the Gibbs ensemble is shown to have maximal average (Bayes-optimal) performance. This upper bound for continuous vectors is extended to a discrete space, resulting in the clipped center of mass of the Gibbs ensemble having maximal average performance among the binary vectors. To calculate the performance of this best binary vector, the geometric properties of the center of mass of binary vectors are studied. The surprising result is found that the center of mass of infinite binary vectors which obey some simple constraints, is again a binary vector. When disorder is taken into account in the calculation, however, a vector with continuous components is obtained. The performance of the best binary vector is calculated and shown to always lie above that of Gibbs learning and below the Bayes-optimal performance. Making use of a variational approach under the replica symmetric ansatz, an optimal potential is constructed in the limits of zero temperature and mutual overlap 1. Minimization of this potential

  18. Decays of the vector glueball

    CERN Document Server

    Giacosa, Francesco; Janowski, Stanislaus

    2016-01-01

    We calculate two- and three-body decays of the (lightest) vector glueball into (pseudo)scalar, (axial-)vector, as well as pseudovector and excited vector mesons. By setting the mass of this yet hypothetical vector glueball to 3.8 GeV as predicted by Lattice QCD, many branching ratios can be computed and represent a parameter-free prediction of our approach. We find that the decay mode $\\omega\\pi\\pi$ should be one of the largest (both through the decay chain $\\mathcal{O}\\rightarrow b_{1}\\pi\\rightarrow$ $\\omega\\pi\\pi$ and through the direct coupling $\\mathcal{O}\\rightarrow\\omega\\pi\\pi$)$.$ Similarly, the (direct and indirect) decay into $\\pi KK^{\\ast}(892)$ is sizable. Moreover, the decays into $\\rho\\pi$ and $K^{\\ast}(892)K$ are, although subleading, possible and could play a role in explaining the $\\rho\\pi$ puzzle of the charmonium state $\\psi(2S)$ thank to a (small) mixing with the vector glueball. The vector glueball can be directly formed at the ongoing BESIII experiment as well as at the future PANDA exper...

  19. Axisymmetric Coanda-assisted vectoring

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Dustin; Smith, Barton L. [Utah State University, Mechanical and Aerospace Engineering, Logan, UT (United States)

    2009-01-15

    An experimental demonstration of a jet vectoring technique used in our novel spray method called Coanda-assisted Spray Manipulation (CSM) is presented. CSM makes use of the Coanda effect on axisymmetric geometries through the interaction of two jets: a primary jet and a control jet. The primary jet has larger volume flow rate but generally a smaller momentum flux than the control jet. The primary jet flows through the center of a rounded collar. The control jet is parallel to the primary and is adjacent to the convex collar. The Reynolds number range for the primary jet at the exit plane was between 20,000 and 80,000. The flow was in the incompressible Mach number range (Mach<0.3). The control jet attaches to the convex wall and vectors according to known Coanda effect principles, entraining and vectoring the primary jet, resulting in controllable r-{theta} directional spraying. Several annular control slots and collar radii were tested over a range of momentum flux ratios to determine the effects of these variables on the vectored jet angle and spreading. Two and Three-component Particle Image Velocimetry systems were used to determine the vectoring angle and the profile of the combined jet in each experiment. The experiments show that the control slot and expansion radius, along with the momentum ratios of the two jets predominantly affected the vectoring angle and profile of the combined jets. (orig.)

  20. Vectoring of parallel synthetic jets

    Science.gov (United States)

    Berk, Tim; Ganapathisubramani, Bharathram; Gomit, Guillaume

    2015-11-01

    A pair of parallel synthetic jets can be vectored by applying a phase difference between the two driving signals. The resulting jet can be merged or bifurcated and either vectored towards the actuator leading in phase or the actuator lagging in phase. In the present study, the influence of phase difference and Strouhal number on the vectoring behaviour is examined experimentally. Phase-locked vorticity fields, measured using Particle Image Velocimetry (PIV), are used to track vortex pairs. The physical mechanisms that explain the diversity in vectoring behaviour are observed based on the vortex trajectories. For a fixed phase difference, the vectoring behaviour is shown to be primarily influenced by pinch-off time of vortex rings generated by the synthetic jets. Beyond a certain formation number, the pinch-off timescale becomes invariant. In this region, the vectoring behaviour is determined by the distance between subsequent vortex rings. We acknowledge the financial support from the European Research Council (ERC grant agreement no. 277472).

  1. Black holes with vector hair

    Science.gov (United States)

    Fan, Zhong-Ying

    2016-09-01

    In this paper, we consider Einstein gravity coupled to a vector field, either minimally or non-minimally, together with a vector potential of the type V = 2{Λ}_0+1/2{m}^2{A}^2 + {γ}_4{A}^4 . For a simpler non-minimally coupled theory with Λ0 = m = γ4 = 0, we obtain both extremal and non-extremal black hole solutions that are asymptotic to Minkowski space-times. We study the global properties of the solutions and derive the first law of thermodynamics using Wald formalism. We find that the thermodynamical first law of the extremal black holes is modified by a one form associated with the vector field. In particular, due to the existence of the non-minimal coupling, the vector forms thermodynamic conjugates with the graviton mode and partly contributes to the one form modifying the first law. For a minimally coupled theory with Λ0 ≠ 0, we also obtain one class of asymptotically flat extremal black hole solutions in general dimensions. This is possible because the parameters ( m 2 , γ4) take certain values such that V = 0. In particular, we find that the vector also forms thermodynamic conjugates with the graviton mode and contributes to the corresponding first law, although the non-minimal coupling has been turned off. Thus all the extremal black hole solutions that we obtain provide highly non-trivial examples how the first law of thermodynamics can be modified by a either minimally or non-minimally coupled vector field. We also study Gauss-Bonnet gravity non-minimally coupled to a vector and obtain asymptotically flat black holes and Lifshitz black holes.

  2. Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon.

    Science.gov (United States)

    Akbulut, Hakan; Zhang, Lixin; Tang, Yucheng; Deisseroth, Albert

    2003-05-01

    Prodrug activating transcription unit gene therapy is one of several promising approaches to cancer gene therapy. Combining that approach with conditionally replication-competent viral vectors that are truly tumor specific has been an important objective of recent work. In this study, we report the construction of a new conditionally replication-competent bicistronic adenoviral vector in which the cytosine deaminase (CD) gene and the E1a gene are driven by the L-plastin tumor-specific promoter (AdLpCDIRESE1a). A similar vector driven by the CMV promoter has also been constructed (AdCMVCDIRESE1a) as a control. We have carried out in vitro cytotoxicity in carcinomas of the breast, ovary and colon, and in vivo efficacy studies with these vectors in an animal model of colon cancer. While the addition of the AdLpCDIRESE1a vector to established cancer cell lines showed significant cytotoxicity in tumor cells derived from carcinomas of the breast (MCF-7), colon (HTB-38) and ovary (Ovcar 5), no significant toxicity was seen in explant cultures of normal human mammary epithelial cells (HMEC) exposed to this vector. The addition of 5-fluorocytosine (5FC) significantly increased the cytotoxicity in an additive fashion of both the AdLpCDIRESE1a and AdCMVCDIRESE1a vectors as well as that of the AdLpCD replication incompetent vector to established tumor cell lines. However, no significant cytotoxicity was observed with the addition of 5FC to explant cultures of normal human mammary epithelial cells that had been exposed to the L-plastin-driven vectors. Studies with mixtures of infected and uninfected tumor cell lines showed that the established cancer cell lines infected with the AdLpCDIRESE1a vector generated significant toxicity to surrounding uninfected cells (the "bystander effect") even at a ratio of 0.25 of infected cells to infected + uninfected cells in the presence of 5FC. The injection of the AdLpCDIRESE1a vector into subcutaneous deposits of human tumor nodules in the

  3. The Duality on Vector Optimization Problems

    Institute of Scientific and Technical Information of China (English)

    HUANG Long-guang

    2012-01-01

    Duality framework on vector optimization problems in a locally convex topological vector space are established by using scalarization with a cone-strongly increasing function.The dualities for the scalar convex composed optimization problems and for general vector optimization problems are studied.A general approach for studying duality in vector optimization problems is presented.

  4. The biological control of disease vectors.

    Science.gov (United States)

    Okamoto, Kenichi W; Amarasekare, Priyanga

    2012-09-21

    Vector-borne diseases are common in nature and can have a large impact on humans, livestock and crops. Biological control of vectors using natural enemies or competitors can reduce vector density and hence disease transmission. However, the indirect interactions inherent in host-vector disease systems make it difficult to use traditional pest control theory to guide biological control of disease vectors. This necessitates a conceptual framework that explicitly considers a range of indirect interactions between the host-vector disease system and the vector's biological control agent. Here we conduct a comparative analysis of the efficacy of different types of biological control agents in controlling vector-borne diseases. We report three key findings. First, highly efficient predators and parasitoids of the vector prove to be effective biological control agents, but highly virulent pathogens of the vector also require a high transmission rate to be effective. Second, biocontrol agents can successfully reduce long-term host disease incidence even though they may fail to reduce long-term vector densities. Third, inundating a host-vector disease system with a natural enemy of the vector has little or no effect on reducing disease incidence, but inundating the system with a competitor of the vector has a large effect on reducing disease incidence. The comparative framework yields predictions that are useful in developing biological control strategies for vector-borne diseases. We discuss how these predictions can inform ongoing biological control efforts for host-vector disease systems.

  5. A NOTE ON VECTOR CASCADE ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Qiu-hui Chen; Jin-zhao Liu; Wen-sheng Zhang

    2002-01-01

    The focus of this paper is on the relationship between accuracy of multivariate refinable vector and vector cascade algorithm. We show that, if the vector cascade algorithm (1.5) with isotropic dilation converges to a vector-valued function with regularity, then the initial function must satisfy the Strang-Fix conditions.

  6. Implementing Bayesian Vector Autoregressions Implementing Bayesian Vector Autoregressions

    Directory of Open Access Journals (Sweden)

    Richard M. Todd

    1988-03-01

    Full Text Available Implementing Bayesian Vector Autoregressions This paper discusses how the Bayesian approach can be used to construct a type of multivariate forecasting model known as a Bayesian vector autoregression (BVAR. In doing so, we mainly explain Doan, Littermann, and Sims (1984 propositions on how to estimate a BVAR based on a certain family of prior probability distributions. indexed by a fairly small set of hyperparameters. There is also a discussion on how to specify a BVAR and set up a BVAR database. A 4-variable model is used to iliustrate the BVAR approach.

  7. Vector Encoding in Biochemical Networks

    Science.gov (United States)

    Potter, Garrett; Sun, Bo

    Encoding of environmental cues via biochemical signaling pathways is of vital importance in the transmission of information for cells in a network. The current literature assumes a single cell state is used to encode information, however, recent research suggests the optimal strategy utilizes a vector of cell states sampled at various time points. To elucidate the optimal sampling strategy for vector encoding, we take an information theoretic approach and determine the mutual information of the calcium signaling dynamics obtained from fibroblast cells perturbed with different concentrations of ATP. Specifically, we analyze the sampling strategies under the cases of fixed and non-fixed vector dimension as well as the efficiency of these strategies. Our results show that sampling with greater frequency is optimal in the case of non-fixed vector dimension but that, in general, a lower sampling frequency is best from both a fixed vector dimension and efficiency standpoint. Further, we find the use of a simple modified Ornstein-Uhlenbeck process as a model qualitatively captures many of our experimental results suggesting that sampling in biochemical networks is based on a few basic components.

  8. Axisymmetric Coanda-assisted vectoring

    Science.gov (United States)

    Allen, Dustin; Smith, Barton L.

    2009-01-01

    An experimental demonstration of a jet vectoring technique used in our novel spray method called Coanda-assisted Spray Manipulation (CSM) is presented. CSM makes use of the Coanda effect on axisymmetric geometries through the interaction of two jets: a primary jet and a control jet. The primary jet has larger volume flow rate but generally a smaller momentum flux than the control jet. The primary jet flows through the center of a rounded collar. The control jet is parallel to the primary and is adjacent to the convex collar. The Reynolds number range for the primary jet at the exit plane was between 20,000 and 80,000. The flow was in the incompressible Mach number range (Mach Coanda effect principles, entraining and vectoring the primary jet, resulting in controllable r - θ directional spraying. Several annular control slots and collar radii were tested over a range of momentum flux ratios to determine the effects of these variables on the vectored jet angle and spreading. Two and Three-component Particle Image Velocimetry systems were used to determine the vectoring angle and the profile of the combined jet in each experiment. The experiments show that the control slot and expansion radius, along with the momentum ratios of the two jets predominantly affected the vectoring angle and profile of the combined jets.

  9. A generalized nonlocal vector calculus

    Science.gov (United States)

    Alali, Bacim; Liu, Kuo; Gunzburger, Max

    2015-10-01

    A nonlocal vector calculus was introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) that has proved useful for the analysis of the peridynamics model of nonlocal mechanics and nonlocal diffusion models. A formulation is developed that provides a more general setting for the nonlocal vector calculus that is independent of particular nonlocal models. It is shown that general nonlocal calculus operators are integral operators with specific integral kernels. General nonlocal calculus properties are developed, including nonlocal integration by parts formula and Green's identities. The nonlocal vector calculus introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) is shown to be recoverable from the general formulation as a special example. This special nonlocal vector calculus is used to reformulate the peridynamics equation of motion in terms of the nonlocal gradient operator and its adjoint. A new example of nonlocal vector calculus operators is introduced, which shows the potential use of the general formulation for general nonlocal models.

  10. Ensemble Dynamics and Bred Vectors

    CERN Document Server

    Balci, Nusret; Restrepo, Juan M; Sell, George R

    2011-01-01

    We introduce the new concept of an EBV to assess the sensitivity of model outputs to changes in initial conditions for weather forecasting. The new algorithm, which we call the "Ensemble Bred Vector" or EBV, is based on collective dynamics in essential ways. By construction, the EBV algorithm produces one or more dominant vectors. We investigate the performance of EBV, comparing it to the BV algorithm as well as the finite-time Lyapunov Vectors. We give a theoretical justification to the observed fact that the vectors produced by BV, EBV, and the finite-time Lyapunov vectors are similar for small amplitudes. Numerical comparisons of BV and EBV for the 3-equation Lorenz model and for a forced, dissipative partial differential equation of Cahn-Hilliard type that arises in modeling the thermohaline circulation, demonstrate that the EBV yields a size-ordered description of the perturbation field, and is more robust than the BV in the higher nonlinear regime. The EBV yields insight into the fractal structure of th...

  11. Fiber propagation of vector modes

    CERN Document Server

    Ndagano, Bienvenu; McLaren, Melanie; Duparre, Michael; Forbes, Andrew

    2015-01-01

    Here we employ both dynamic and geometric phase control of light to produce radially modulated vector-vortex modes, the natural modes of optical fibers. We then measure these modes using a vector modal decomposition set-up as well as a tomography measurement, the latter providing a degree of the non-separability of the vector states, akin to an entanglement measure for quantum states. We demonstrate the versatility of the approach by creating the natural modes of a step-index fiber, which are known to exhibit strong mode coupling, and measure the modal cross-talk and non-separability decay during propagation. Our approach will be useful in mode division multiplexing schemes for transport of classical and quantum states.

  12. 3D vector flow imaging

    DEFF Research Database (Denmark)

    Pihl, Michael Johannes

    The main purpose of this PhD project is to develop an ultrasonic method for 3D vector flow imaging. The motivation is to advance the field of velocity estimation in ultrasound, which plays an important role in the clinic. The velocity of blood has components in all three spatial dimensions, yet...... conventional methods can estimate only the axial component. Several approaches for 3D vector velocity estimation have been suggested, but none of these methods have so far produced convincing in vivo results nor have they been adopted by commercial manufacturers. The basis for this project is the Transverse...... on the TO fields are suggested. They can be used to optimize the TO method. In the third part, a TO method for 3D vector velocity estimation is proposed. It employs a 2D phased array transducer and decouples the velocity estimation into three velocity components, which are estimated simultaneously based on 5...

  13. Gauge Theories of Vector Particles

    Science.gov (United States)

    Glashow, S. L.; Gell-Mann, M.

    1961-04-24

    The possibility of generalizing the Yang-Mills trick is examined. Thus we seek theories of vector bosons invariant under continuous groups of coordinate-dependent linear transformations. All such theories may be expressed as superpositions of certain "simple" theories; we show that each "simple theory is associated with a simple Lie algebra. We may introduce mass terms for the vector bosons at the price of destroying the gauge-invariance for coordinate-dependent gauge functions. The theories corresponding to three particular simple Lie algebras - those which admit precisely two commuting quantum numbers - are examined in some detail as examples. One of them might play a role in the physics of the strong interactions if there is an underlying super-symmetry, transcending charge independence, that is badly broken. The intermediate vector boson theory of weak interactions is discussed also. The so-called "schizon" model cannot be made to conform to the requirements of partial gauge-invariance.

  14. Skyrmions with vector mesons revisited

    CERN Document Server

    Oh, Yongseok

    2014-01-01

    In order to develop a model that can describe both a single baryon and multi-baryon systems on the same footing, we re-investigate the Skyrme model in a chiral Lagrangian derived from the hidden local symmetry (HLS) up to $O(p^4)$ including the homogeneous Wess-Zumino terms. We use the master formulas that connect the parameters of the HLS Lagrangian and a class of holographic QCD models, which provides a controllable way to determine the low-energy constants of the Lagrangian once the pion decay constant and the vector meson mass are given. Therefore, this model allows us to study the role of vector mesons in the skyrmion structure. We find that the $\\rho$ and $\\omega$ vector mesons have different roles in the skyrmion structure and that the $\\omega$ meson has an important role in the properties of the nucleon.

  15. Toward lattice fractional vector calculus

    Science.gov (United States)

    Tarasov, Vasily E.

    2014-09-01

    An analog of fractional vector calculus for physical lattice models is suggested. We use an approach based on the models of three-dimensional lattices with long-range inter-particle interactions. The lattice analogs of fractional partial derivatives are represented by kernels of lattice long-range interactions, where the Fourier series transformations of these kernels have a power-law form with respect to wave vector components. In the continuum limit, these lattice partial derivatives give derivatives of non-integer order with respect to coordinates. In the three-dimensional description of the non-local continuum, the fractional differential operators have the form of fractional partial derivatives of the Riesz type. As examples of the applications of the suggested lattice fractional vector calculus, we give lattice models with long-range interactions for the fractional Maxwell equations of non-local continuous media and for the fractional generalization of the Mindlin and Aifantis continuum models of gradient elasticity.

  16. Bred vectors, singular vectors, and Lyapunov vectors in simple and complex models

    Science.gov (United States)

    Norwood, Adrienne

    We compute and compare three types of vectors frequently used to explore the instability properties of dynamical models, Lyapunov vectors (LVs), singular vectors (SVs), and bred vectors (BVs). The first model is the Lorenz (1963) three-variable model. We find BVs align with the locally fastest growing LV, which is often the second fastest growing global LV. The growth rates of the three types of vectors reveal all predict regime changes and durations of new regimes, as shown for BVs by Evans et al. (2004). The second model is the toy 'atmosphere-ocean model' developed by Pena and Kalnay (2004) coupling three Lorenz (1963) models with different time scales to test the effects of fast and slow modes of growth on the dynamical vectors. A fast 'extratropical atmosphere' is weakly coupled to a fast 'tropical atmosphere' which is strongly coupled to a slow 'ocean' system, the latter coupling imitating the tropical El Nino--Southern Oscillation. BVs separate the fast and slow modes of growth through appropriate selection of the breeding parameters. LVs successfully separate the fast 'extratropics' but cannot completely decouple the 'tropics' from the 'ocean,' leading to 'coupled' LVs that are affected by both systems but mainly dominated by one. SVs identify the fast modes but cannot capture the slow modes until the fast 'extratropics' are replaced with faster 'convection.' The dissimilar behavior of the three types of vectors degrades the similarities of the subspaces they inhabit (Norwood et al. 2013). The third model is a quasi-geostrophic channel model (Rotunno and Bao 1996) that is a simplification of extratropical synoptic-scale motions with baroclinic instabilities only. We were unable to successfully compute LVs for it. However, randomly initialized BVs quickly converge to a single vector that is the leading LV. The last model is the SPEEDY model created by Molteni (2003). It is a simplified general atmospheric circulation model with several types of instabilities

  17. Black Holes With Vector Hair

    OpenAIRE

    Fan, Zhong-Ying

    2016-01-01

    In this paper, we consider Einstein gravity coupled to a vector field, either minimally or non-minimally, together with a vector potential of the type $V=2\\Lambda_0+\\ft 12 m^2 A^2+\\gamma_4 A^4$. For a simpler non-minimally coupled theory with $\\Lambda_0=m=\\gamma_4=0$, we obtain both extremal and non-extremal black hole solutions that are asymptotic to Minkowski space-times. We study the global properties of the solutions and derive the first law of thermodynamics using Wald formalism. We find...

  18. Requirements for airborne vector gravimetry

    Science.gov (United States)

    Schwarz, K. P.; Colombo, O.; Hein, G.; Knickmeyer, E. T.

    1992-01-01

    The objective of airborne vector gravimetry is the determination of the full gravity disturbance vector along the aircraft trajectory. The paper briefly outlines the concept of this method using a combination of inertial and GPS-satellite data. The accuracy requirements for users in geodesy and solid earth geophysics, oceanography and exploration geophysics are then specified. Using these requirements, accuracy specifications for the GPS subsystem and the INS subsystem are developed. The integration of the subsystems and the problems connected with it are briefly discussed and operational methods are indicated that might reduce some of the stringent accuracy requirements.

  19. Learning with Support Vector Machines

    CERN Document Server

    Campbell, Colin

    2010-01-01

    Support Vectors Machines have become a well established tool within machine learning. They work well in practice and have now been used across a wide range of applications from recognizing hand-written digits, to face identification, text categorisation, bioinformatics, and database marketing. In this book we give an introductory overview of this subject. We start with a simple Support Vector Machine for performing binary classification before considering multi-class classification and learning in the presence of noise. We show that this framework can be extended to many other scenarios such a

  20. The vector BPS Skyrme model

    OpenAIRE

    Adam, C.; C. Naya; Sanchez-Guillen, J.; Wereszczynski, A.

    2012-01-01

    We analyze the vector meson formulation of the BPS Skyrme model in (3+1) dimensions, where the term of sixth power in first derivatives characteristic for the original, integrable BPS Skyrme model (the topological or baryon current squared) is replaced by a coupling between the vector meson $\\omega_\\mu$ and the baryon current. We find that the model remains integrable in the sense of generalized integrability and almost solvable (reducible to a set of two first order ODEs) for any value of th...

  1. On Spinors and Null Vectors

    CERN Document Server

    Budinich, Marco

    2014-01-01

    We investigate the relations between spinors and null vectors in Clifford algebra with particular emphasis on the conditions that a spinor must satisfy to be simple (also: pure). In particular we prove: i) a new property for null vectors: each of them bisects spinor space into two parts of equal size; ii) that simple spinors form one-dimensional subspaces of spinor space; iii) a necessary and sufficient condition for a spinor to be simple that generalizes a theorem of Cartan and Chevalley that appears now as a corollary of this result. We also show how to write down easily the most general spinor with a given associated totally null plane.

  2. Topological vector spaces and distributions

    CERN Document Server

    Horvath, John

    2012-01-01

    ""The most readable introduction to the theory of vector spaces available in English and possibly any other language.""-J. L. B. Cooper, MathSciNet ReviewMathematically rigorous but user-friendly, this classic treatise discusses major modern contributions to the field of topological vector spaces. The self-contained treatment includes complete proofs for all necessary results from algebra and topology. Suitable for undergraduate mathematics majors with a background in advanced calculus, this volume will also assist professional mathematicians, physicists, and engineers.The precise exposition o

  3. Reference vectors in economic choice

    Directory of Open Access Journals (Sweden)

    Teycir Abdelghani GOUCHA

    2013-07-01

    Full Text Available In this paper the introduction of notion of reference vector paves the way for a combination of classical and social approaches in the framework of referential preferences given by matrix groups. It is shown that individual demand issue from rational decision does not depend on that reference.

  4. Vector ecology of equine piroplasmosis

    Science.gov (United States)

    Equine piroplasmosis (EP) is a disease of equidae including horses, donkeys, mules and zebras caused by either of two protozoan parasites, Theileria equi or Babesia caballi. These parasites are biologically transmitted between hosts via tick-vectors and although they have inherent differences, they ...

  5. The consequences of poor vectorization

    CERN Document Server

    CERN. Geneva

    2016-01-01

    This talk briefly discusses the vectorization problem and how it impacts scientific and engineering systems. A simple cost model of designing such system in context of different phases of software lifetime is considered. Finally a concept for scalable solution is presented.

  6. Vector-valued fuzzy multifunctions

    Directory of Open Access Journals (Sweden)

    Ismat Beg

    2001-01-01

    Full Text Available Some of the properties of vector-valued fuzzy multifunctions are studied. The notion of sum fuzzy multifunction, convex hull fuzzy multifunction, close convex hull fuzzy multifunction, and upper demicontinuous are given, and some of the properties of these fuzzy multifunctions are investigated.

  7. On Weighted Support Vector Regression

    DEFF Research Database (Denmark)

    Han, Xixuan; Clemmensen, Line Katrine Harder

    2014-01-01

    We propose a new type of weighted support vector regression (SVR), motivated by modeling local dependencies in time and space in prediction of house prices. The classic weights of the weighted SVR are added to the slack variables in the objective function (OF‐weights). This procedure directly...

  8. Vector Space Over Division Ring

    OpenAIRE

    Kleyn, Aleks

    2005-01-01

    A system of linear equations over a skew field has properties similar to properties of a system of linear equations over a field. Even noncommutativity of a product creates a new picture the properties of system of linear equations and of vector space over skew-field have a close relationship.

  9. Vector-meson dominance revisited

    Directory of Open Access Journals (Sweden)

    Terschlüsen Carla

    2012-12-01

    Full Text Available The interaction of mesons with electromagnetism is often well described by the concept of vector-meson dominance (VMD. However, there are also examples where VMD fails. A simple chiral Lagrangian for pions, rho and omega mesons is presented which can account for the respective agreement and disagreement between VMD and phenomenology in the sector of light mesons.

  10. Parallel Sparse Matrix - Vector Product

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Lazarov, Boyan Stefanov; Dammann, Bernd

    This technical report contains a case study of a sparse matrix-vector product routine, implemented for parallel execution on a compute cluster with both pure MPI and hybrid MPI-OpenMP solutions. C++ classes for sparse data types were developed and the report shows how these class can be used...

  11. Phase transitions in Vector Quantization

    NARCIS (Netherlands)

    Witoelar, Aree; Ghosh, Anarta; Biehl, Michael; Verleysen, Michel

    2008-01-01

    We study Winner-Takes-All and rank based Vector Quantization along the lines of the statistical physics of off-line learning. Typical behavior of the system is obtained within a model where high-dimensional training data are drawn from a mixture of Gaussians. The analysis becomes exact in the simpli

  12. Portfolio Analysis for Vector Calculus

    Science.gov (United States)

    Kaplan, Samuel R.

    2015-01-01

    Classic stock portfolio analysis provides an applied context for Lagrange multipliers that undergraduate students appreciate. Although modern methods of portfolio analysis are beyond the scope of vector calculus, classic methods reinforce the utility of this material. This paper discusses how to introduce classic stock portfolio analysis in a…

  13. Beam quality measure for vector beams.

    Science.gov (United States)

    Ndagano, Bienvenu; Sroor, Hend; McLaren, Melanie; Rosales-Guzmán, Carmelo; Forbes, Andrew

    2016-08-01

    Vector beams have found a myriad of applications, from laser materials processing to microscopy, and are now easily produced in the laboratory. They are usually differentiated from scalar beams by qualitative measures, for example, visual inspection of beam profiles after a rotating polarizer. Here we introduce a quantitative beam quality measure for vector beams and demonstrate it on cylindrical vector vortex beams. We show how a single measure can be defined for the vector quality, from 0 (purely scalar) to 1 (purely vector). Our measure is derived from a quantum toolkit, which we show applies to classical vector beams. PMID:27472580

  14. Vector variational inequalities and their relations with vector optimization

    Directory of Open Access Journals (Sweden)

    Surjeet Kaur Suneja

    2014-01-01

    Full Text Available In this paper, K- quasiconvex, K- pseudoconvex and other related functions have been introduced in terms of their Clarke subdifferentials, where is an arbitrary closed convex, pointed cone with nonempty interior. The (strict, weakly -pseudomonotonicity, (strict K- naturally quasimonotonicity and K- quasimonotonicity of Clarke subdifferential maps have also been defined. Further, we introduce Minty weak (MVVIP and Stampacchia weak (SVVIP vector variational inequalities over arbitrary cones. Under regularity assumption, we have proved that a weak minimum solution of vector optimization problem (VOP is a solution of (SVVIP and under the condition of K- pseudoconvexity we have obtained the converse for MVVIP (SVVIP. In the end we study the interrelations between these with the help of strict K-naturally quasimonotonicity of Clarke subdifferential map.

  15. Vector-Boson Fusion and Vector-Boson Scattering

    CERN Document Server

    Rauch, Michael

    2016-01-01

    Vector-boson fusion and vector-boson scattering are an important class of processes for the Large Hadron Collider at CERN. It is characterized by two high-energetic jets in the forward regions of the detector and reduced jet activity in the central region. The higher center-of-mass energy during the current and subsequent runs strongly boosts the sensitivity in these processes and allows to test the predictions of the Standard Model to a high precision. In this review, we first present the main phenomenological features of vector-boson fusion and scattering processes. Then we discuss the effects of higher-order corrections, which are available at NLO QCD for all processes and up to N3LO QCD and NLO electro-weak for VBF-H production. An additional refinement is the addition of parton-shower effects, where recently a lot of progress has been made. The appearance of triple and quartic gauge vertices in the production processes enables us to probe anomalous gauge couplings. We introduce and compare the different ...

  16. SYSTEM OF GENERALIZED VECTOR VARIATIONAL INEQUALITIES

    Institute of Scientific and Technical Information of China (English)

    Fang Yaping; Huang Nanjing

    2005-01-01

    In this paper, the authors introduce and study system of generalized vector variational inequalities. Under suitable conditions, the existence of solutions for system of generalized vector variational inequalities is presented by Kakutani-Fan-Glicksberg fixed point theorem.

  17. Transversals of Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    Vector fields in the complex plane are defined by assigning the vector determined by the value P(z) to each point z in the complex plane, where P is a polynomial of one complex variable. We consider special families of so-called rotated vector fields that are determined by a polynomial multiplied...... by rotational constants. Transversals are a certain class of curves for such a family of vector fields that represent the bifurcation states for this family of vector fields. More specifically, transversals are curves that coincide with a homoclinic separatrix for some rotation of the vector field. Given...... a concrete polynomial, it seems to take quite a bit of work to prove that it is generic, i.e. structurally stable. This has been done for a special class of degree d polynomial vector fields having simple equilibrium points at the d roots of unity, d odd. In proving that such vector fields are generic...

  18. Introduction to vector velocity imaging

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Udesen, Jesper; Hansen, Kristoffer Lindskov;

    Current ultrasound scanners can only estimate the velocity along the ultrasound beam and this gives rise to the cos() factor on all velocity estimates. This is a major limitation as most vessels are close to perpendicular to the beam. Also the angle varies as a function of space and time making...... it virtually impossible to compensate for the factor and obtain correct velocity estimates for either CFM or spectral velocity estimation. This talk will describe methods for finding the correct velocity by estimating both the axial and lateral component of the velocity vector. The transverse oscillation...... method introduces an ultrasound field that oscillation not only along the ultrasound beam both also transverse to it to estimate both the lateral and axial velocity for the full velocity vector. The correct velocity magnitude can be found from this as well as the instantaneous angle. This can be obtained...

  19. ELVIS - ELectromagnetic Vector Information Sensor

    CERN Document Server

    Bergman, J E S; Thidé, B; Ananthakrishnan, S; Wahlund, J E; Karlsson, R L; Puccio, W; Carozzi, T D; Kale, P

    2005-01-01

    The ELVIS instrument was recently proposed by the authors for the Indian Chandrayaan-1 mission to the Moon and is presently under consideration by the Indian Space Research Organisation (ISRO). The scientific objective of ELVIS is to explore the electromagnetic environment of the moon. ELVIS samples the full three-dimensional (3D) electric field vector, E(x,t), up to 18 MHz, with selective Nyqvist frequency bandwidths down to 5 kHz, and one component of the magnetic field vector, B(x,t), from a few Hz up to 100 kHz.As a transient detector, ELVIS is capable of detecting pulses with a minimum pulse width of 5 ns. The instrument comprises three orthogonal electric dipole antennas, one magnetic search coil antenna and a four-channel digital sampling system, utilising flexible digital down conversion and filtering together with state-of-the-art onboard digital signal processing.

  20. Lentiviral vectors in cancer immunotherapy.

    Science.gov (United States)

    Oldham, Robyn Aa; Berinstein, Elliot M; Medin, Jeffrey A

    2015-01-01

    Basic science advances in cancer immunotherapy have resulted in various treatments that have recently shown success in the clinic. Many of these therapies require the insertion of genes into cells to directly kill them or to redirect the host's cells to induce potent immune responses. Other analogous therapies work by modifying effector cells for improved targeting and enhanced killing of tumor cells. Initial studies done using γ-retroviruses were promising, but safety concerns centered on the potential for insertional mutagenesis have highlighted the desire to develop other options for gene delivery. Lentiviral vectors (LVs) have been identified as potentially more effective and safer alternative delivery vehicles. LVs are now in use in clinical trials for many different types of inherited and acquired disorders, including cancer. This review will discuss current knowledge of LVs and the applications of this viral vector-based delivery vehicle to cancer immunotherapy.

  1. Vector Fields in Holographic Cosmology

    CERN Document Server

    Hartle, James B; Hertog, Thomas

    2013-01-01

    We extend the holographic formulation of the semiclassical no-boundary wave function (NBWF) to models with Maxwell vector fields. It is shown that the familiar saddle points of the NBWF have a representation in which a regular, Euclidean asymptotic AdS geometry smoothly joins onto a Lorentzian asymptotically de Sitter universe through a complex transition region. The tree level probabilities of Lorentzian histories are fully specified by the action of the AdS region of the saddle points. The scalar and vector matter profiles in this region are complex from an AdS viewpoint, with universal asymptotic phases. The dual description of the semiclassical NBWF thus involves complex deformations of Euclidean CFTs.

  2. Class Vectors: Embedding representation of Document Classes

    OpenAIRE

    Sachan, Devendra Singh; Kumar, Shailesh

    2015-01-01

    Distributed representations of words and paragraphs as semantic embeddings in high dimensional data are used across a number of Natural Language Understanding tasks such as retrieval, translation, and classification. In this work, we propose "Class Vectors" - a framework for learning a vector per class in the same embedding space as the word and paragraph embeddings. Similarity between these class vectors and word vectors are used as features to classify a document to a class. In experiment o...

  3. NEVILLE-TYPE VECTOR VALUED RATIONAL INTERPOLANTS

    Institute of Scientific and Technical Information of China (English)

    陈之兵; 顾传青; 徐晨

    2004-01-01

    A new kind of vector valued rational interpolants is established by means of Samelson inverse, with scalar numerator and vector valued denominator. It is essen tially different from that of Graves-Morris(1983), where the interpolants are constructed by Thiele-type continued fractions with vector valued numerator and scalar denominator. The new approach is more suitable to calculate the value of a vector valued function for a given point. And an error formula is also given and proven.

  4. Fast Support Vector Machines for Continuous Data

    OpenAIRE

    Kramer, Kurt A.; Hall, Lawrence O.; Goldgof, Dmitry B.; Remsen, Andrew; Luo, Tong

    2009-01-01

    Support vector machines can be trained to be very accurate classifiers and have been used in many applications. However, the training and to a lesser extent prediction time of support vector machines on very large data sets can be very long. This paper presents a fast compression method to scale up support vector machines to large data sets. A simple bit reduction method is applied to reduce the cardinality of the data by weighting representative examples. We then develop support vector machi...

  5. Problems of vector Lagrangians in field theories

    International Nuclear Information System (INIS)

    A vector Lagrange approach to the Dirac spinor field and the relationship between the vector Lagrangians for the spinor and electromagnetic fields are considered. A vector Lagrange approach for the system of interacting electromagnetic B=(Bμυ)=(E-bar,H-bar) and spinor Ψ fields is constructed. New Lagrangians (scalar and vector) for electromagnetic field in terms of field strengths are found. The foundations of two new QED models are formulated

  6. VEST: abstract vector calculus simplification in Mathematica

    OpenAIRE

    Squire, Jonathan; Burby, Joshua; Qin, Hong

    2013-01-01

    We present a new package, VEST (Vector Einstein Summation Tools), that performs abstract vector calculus computations in Mathematica. Through the use of index notation, VEST is able to reduce three-dimensional scalar and vector expressions of a very general type to a well defined standard form. In addition, utilizing properties of the Levi-Civita symbol, the program can derive types of multi-term vector identities that are not recognized by reduction, subsequently applying these to simplify l...

  7. Vector fields in holographic cosmology

    OpenAIRE

    Hartle, James B.; Hawking, S. W.; Hertog, Thomas

    2013-01-01

    We extend the holographic formulation of the semiclassical no-boundary wave function (NBWF) to models with Maxwell vector fields. It is shown that the familiar saddle points of the NBWF have a representation in which a regular, Euclidean asymptotic AdS geometry smoothly joins onto a Lorentzian asymptotically de Sitter universe through a complex transition region. The tree level probabilities of Lorentzian histories are fully specified by the action of the AdS region of the saddle points. The ...

  8. Biological rhythms and vector insects

    Directory of Open Access Journals (Sweden)

    Mirian David Marques

    2013-01-01

    Full Text Available The adjustment of all species, animals and plants, to the Earth’s cyclic environments is ensured by their temporal organisation. The relationships between parasites, vectors and hosts rely greatly upon the synchronisation of their biological rhythms, especially circadian rhythms. In this short note, parasitic infections by Protozoa and by microfilariae have been chosen as examples of the dependence of successful transmission mechanisms on temporal components.

  9. Vector Analysis in GIS Systems

    OpenAIRE

    Životský, Tomáš

    2009-01-01

    This master's thesis deals with the geographic information systems with an emphasis on so-called vector analysis. The aim of the thesisis to create a library that implements the internal representation of geographic data and performs analytical operation over them. The thesis describes the logical structure of the application andthe hierarchy of abstract classes. In the form of pseudo-code isshown a set of individual computing operations. Work is stronglybased on geographic sys...

  10. Toward lattice fractional vector calculus

    International Nuclear Information System (INIS)

    An analog of fractional vector calculus for physical lattice models is suggested. We use an approach based on the models of three-dimensional lattices with long-range inter-particle interactions. The lattice analogs of fractional partial derivatives are represented by kernels of lattice long-range interactions, where the Fourier series transformations of these kernels have a power-law form with respect to wave vector components. In the continuum limit, these lattice partial derivatives give derivatives of non-integer order with respect to coordinates. In the three-dimensional description of the non-local continuum, the fractional differential operators have the form of fractional partial derivatives of the Riesz type. As examples of the applications of the suggested lattice fractional vector calculus, we give lattice models with long-range interactions for the fractional Maxwell equations of non-local continuous media and for the fractional generalization of the Mindlin and Aifantis continuum models of gradient elasticity. (papers)

  11. Modeling vector nonlinear time series using POLYMARS

    NARCIS (Netherlands)

    J.G. de Gooijer; B.K. Ray

    2003-01-01

    A modified multivariate adaptive regression splines method for modeling vector nonlinear time series is investigated. The method results in models that can capture certain types of vector self-exciting threshold autoregressive behavior, as well as provide good predictions for more general vector non

  12. Vector and tensor analysis with applications

    CERN Document Server

    Borisenko, A I; Silverman, Richard A

    1979-01-01

    Concise and readable, this text ranges from definition of vectors and discussion of algebraic operations on vectors to the concept of tensor and algebraic operations on tensors. It also includes a systematic study of the differential and integral calculus of vector and tensor functions of space and time. Worked-out problems and solutions. 1968 edition.

  13. Problems with the Method of Correlated Vectors

    Science.gov (United States)

    Ashton, M.C.; Lee, K.

    2005-01-01

    The method of correlated vectors has been used widely to identify variables that are associated with general intelligence (g). Briefly, this method involves finding the correlation between the vector of intelligence subtests' g-loadings and the vector of those subtests' correlations with the variable in question. We describe two major problems…

  14. Herbivore arthropods benefit from vectoring plant viruses

    NARCIS (Netherlands)

    Belliure, B.; Janssen, A.; Maris, P.C.; Peters, D.; Sabelis, M.W.

    2005-01-01

    Plants infected with pathogens often attract the pathogens' vectors, but it is not clear if this is advantageous to the vectors. We therefore quantified the direct and indirect (through the host plant) effects of a pathogen on its vector. A positive direct effect of the plant-pathogenic Tomato spott

  15. Gaussian statistics for palaeomagnetic vectors

    Science.gov (United States)

    Love, J.J.; Constable, C.G.

    2003-01-01

    With the aim of treating the statistics of palaeomagnetic directions and intensities jointly and consistently, we represent the mean and the variance of palaeomagnetic vectors, at a particular site and of a particular polarity, by a probability density function in a Cartesian three-space of orthogonal magnetic-field components consisting of a single (unimoda) non-zero mean, spherically-symmetrical (isotropic) Gaussian function. For palaeomagnetic data of mixed polarities, we consider a bimodal distribution consisting of a pair of such symmetrical Gaussian functions, with equal, but opposite, means and equal variances. For both the Gaussian and bi-Gaussian distributions, and in the spherical three-space of intensity, inclination, and declination, we obtain analytical expressions for the marginal density functions, the cumulative distributions, and the expected values and variances for each spherical coordinate (including the angle with respect to the axis of symmetry of the distributions). The mathematical expressions for the intensity and off-axis angle are closed-form and especially manageable, with the intensity distribution being Rayleigh-Rician. In the limit of small relative vectorial dispersion, the Gaussian (bi-Gaussian) directional distribution approaches a Fisher (Bingham) distribution and the intensity distribution approaches a normal distribution. In the opposite limit of large relative vectorial dispersion, the directional distributions approach a spherically-uniform distribution and the intensity distribution approaches a Maxwell distribution. We quantify biases in estimating the properties of the vector field resulting from the use of simple arithmetic averages, such as estimates of the intensity or the inclination of the mean vector, or the variances of these quantities. With the statistical framework developed here and using the maximum-likelihood method, which gives unbiased estimates in the limit of large data numbers, we demonstrate how to

  16. On the Distribution of Norm of Vector Projection and Rejection of Two Complex Normal Random Vectors

    Directory of Open Access Journals (Sweden)

    Mehdi Maleki

    2015-01-01

    Full Text Available Vector projection and vector rejection are highly common and useful operations in mathematics, information theory, and signal processing. In this paper, we find the distribution of the norm of projection and rejection vectors when the original vectors are standard complex normally distributed.

  17. Problems and worked solutions in vector analysis

    CERN Document Server

    Shorter, LR

    2014-01-01

    ""A handy book like this,"" noted The Mathematical Gazette, ""will fill a great want."" Devoted to fully worked out examples, this unique text constitutes a self-contained introductory course in vector analysis for undergraduate and graduate students of applied mathematics.Opening chapters define vector addition and subtraction, show how to resolve and determine the direction of two or more vectors, and explain systems of coordinates, vector equations of a plane and straight line, relative velocity and acceleration, and infinitely small vectors. The following chapters deal with scalar and vect

  18. Vaccine Design: Replication-Defective Adenovirus Vectors.

    Science.gov (United States)

    Zhou, Xiangyang; Xiang, Zhiquan; Ertl, Hildegund C J

    2016-01-01

    Replication-defective adenovirus (Ad) vectors were initially developed for gene transfer for correction of genetic diseases. Although Ad vectors achieved high levels of transgene product expression in a variety of target cells, expression of therapeutic proteins was found to be transient as vigorous T cell responses directed to components of the vector as well as the transgene product rapidly eliminate Ad vector-transduced cells. This opened the use of Ad vectors as vaccine carriers and by now a multitude of preclinical as well as clinical studies has shown that Ad vectors induce very potent and sustained transgene product-specific T and B cell responses. This chapter provides guidance on developing E1-deleted Ad vectors based on available viral molecular clones. Specifically, it describes methods for cloning, viral rescue and purification as well as quality control studies. PMID:27076309

  19. Multiscale vector fields for image pattern recognition

    Science.gov (United States)

    Low, Kah-Chan; Coggins, James M.

    1990-01-01

    A uniform processing framework for low-level vision computing in which a bank of spatial filters maps the image intensity structure at each pixel into an abstract feature space is proposed. Some properties of the filters and the feature space are described. Local orientation is measured by a vector sum in the feature space as follows: each filter's preferred orientation along with the strength of the filter's output determine the orientation and the length of a vector in the feature space; the vectors for all filters are summed to yield a resultant vector for a particular pixel and scale. The orientation of the resultant vector indicates the local orientation, and the magnitude of the vector indicates the strength of the local orientation preference. Limitations of the vector sum method are discussed. Investigations show that the processing framework provides a useful, redundant representation of image structure across orientation and scale.

  20. DBSC-Based Grayscale Line Image Vectorization

    Institute of Scientific and Technical Information of China (English)

    Konstantin Melikhov; Feng Tian; Jie Qiu; Quan Chen; Hock Soon Seah

    2006-01-01

    Vector graphics plays an important role in computer animation and imaging technologies. However present techniques and tools cannot fully replace traditional pencil and paper. Additionally, vector representation of an image is not always available. There is not yet a good solution for vectorizing a picture drawn on a paper. This work attempts to solve the problem of vectorizing grayscale line drawings. The solution proposed uses Disk B-Spline curves to represent strokes of an image in vector form. The algorithm builds a vector representation from a grayscale raster image, which can be a scanned picture for instance. The proposed method uses a Gaussian sliding window to calculate skeleton and perceptive width of a stroke. As a result of vectorization, the given image is represented by a set of Disk B-Spline curves.

  1. The vector algebra war: A historical perspective

    CERN Document Server

    Chappell, James M; Hartnett, John G; Abbott, Derek

    2015-01-01

    There are a wide variety of different vector formalisms currently utilized in science. For example, Gibbs three-vectors, spacetime four-vectors, complex spinors for quantum mechanics, quaternions used for rigid body rotations and Clifford multivectors. With such a range of vector formalisms in use, it thus appears that there is as yet no general agreement on a vector formalism suitable for the whole of science. This surprising situation exists today, despite the fact that one of the main goals of nineteenth century science was to correctly describe vectors and the algebra of three-dimensional space. This situation has also had the unfortunate consequence of fragmenting knowledge across many disciplines and requiring a very significant amount of time and effort in learning the different formalisms. We thus review historically the development of our various vector systems and conclude that the Clifford algebra multivector fulfills the goal of correctly describing vectorial quantities in three dimensions.

  2. Vector meson electroproduction in QCD

    Institute of Scientific and Technical Information of China (English)

    LU Juan; CAI Xian-Hao; ZHOU Li-Juan

    2012-01-01

    Based on the generalized QCD vector meson dominance model,we study the electroproduction of a vector meson off a proton in the QCD inspired eikonalized model.Numerical calculations for the total cross section σtot and differential cross section dσ/dt are performed for p,ω and φ meson electroproduction in this paper.Since gluons interact among themselves (self-interaction),two gluons can form a glueball with quantum numbers IG,JPC =0+,2++,decay width Γt ≈ 100 MeV,and mass of mG=2.23 GeV.The three gluons can form a three-gluon colorless bound state with charge conjugation quantum number C =-1,called the Odderon.The mediators of interactions between projectiles (the quark and antiquark pair fluctuated from the virtual photon) and the proton target (a three-quark system) are the tensor glueball and the Odderon.Our calculated results in the tensor glueball and Odderon exchange model fit to the existing data successfully,which evidently shows that our present QCD mechanism is a good description of meson electroproduction off a proton.It should be emphasized that our mechanism is different from the theoretical framework of Block et al.We also believe that the present study and its success are important for the investigation of other vector meson electro- and photoproduction at high energies,as well as for searching for new particles such as tensor glueballs and Odderons,which have been predicted by QCD and the color glass condensate model (CGC).Therefore,in return,it can test the validity of QCD and the CGC model.

  3. Jet vectoring through nozzle asymmetry

    Science.gov (United States)

    Roh, Chris; Rosakis, Alexandros; Gharib, Morteza

    2015-11-01

    Previously, we explored the functionality of a tri-leaflet anal valve of a dragonfly larva. We saw that the dragonfly larva is capable of controlling the three leaflets independently to asymmetrically open the nozzle. Such control resulted in vectoring of the jet in various directions. To further understand the effect of asymmetric nozzle orifice, we tested jet flow through circular asymmetric nozzles. We report the relationship between nozzle asymmetry and redirecting of the jet at various Reynolds numbers. This material is based upon work supported by the National Science Foundation under Grant No. CBET-1511414; additional support by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1144469.

  4. The Vector Valued Quartile Operator

    CERN Document Server

    Lacey, Michael T; Parissis, Ioannis

    2012-01-01

    Certain vector-valued inequalities are shown to hold for a Walsh analog of the bilinear Hilbert transform. These extensions are phrased in terms of a recent notion of quartile type of a UMD (Unconditional Martingale Differences) Banach space X. Every known UMD Banach space has finite quartile type, and it was recently shown that the Walsh analog of Carleson's Theorem holds under a closely related assumption of finite tile type. For a Walsh model of the bilinear Hilbert transform however, the quartile type should be sufficiently close to that of a Hilbert space for our results to hold. A full set of inequalities is quantified in terms of quartile type.

  5. Nonviral Vectors for Gene Delivery

    Science.gov (United States)

    Baoum, Abdulgader Ahmed

    2011-12-01

    The development of nonviral vectors for safe and efficient gene delivery has been gaining considerable attention recently. An ideal nonviral vector must protect the gene against degradation by nuclease in the extracellular matrix, internalize the plasma membrane, escape from the endosomal compartment, unpackage the gene at some point and have no detrimental effects. In comparison to viruses, nonviral vectors are relatively easy to synthesize, less immunogenic, low in cost, and have no limitation in the size of a gene that can be delivered. Significant progress has been made in the basic science and applications of various nonviral gene delivery vectors; however, the majority of nonviral approaches are still inefficient and often toxic. To this end, two nonviral gene delivery systems using either biodegradable poly(D,L-lactide- co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells. PLG nanoparticles were optimized for gene delivery by varying particle surface chemistry using different coating materials that adsorb to the particle surface during formation. A variety of cationic coating materials were studied and compared to more conventional surfactants used for PLG nanoparticle fabrication. Nanoparticles (˜200 nm) efficiently encapsulated plasmids encoding for luciferase (80-90%) and slowly released the same for two weeks. After a delay, moderate levels of gene expression appeared at day 5 for certain positively charged PLG particles and gene expression was maintained for at least two weeks. In contrast, gene expression mediated by polyethyleneimine (PEI) ended at day 5. PLG particles were also significantly less cytotoxic than PEI suggesting the use of these vehicles for localized, sustained gene delivery to the pulmonary epithelium. On the other hand, a more simple method to synthesize 50-200 nm complexes capable of high transfection efficiency or high gene knockdown was

  6. Current progress of polymeric gene vectors

    Institute of Scientific and Technical Information of China (English)

    ZENG Xuan; SUN YunXia; ZHUO RenXi; ZHANG XianZheng

    2011-01-01

    After over 40 years ot progress,gene therapy provides great opportunities for treating diseases from various genetic disorders,infections and cancers.The success of gene therapy largely depends on the availability of suitable gene vectors.As an attractive alternative to virus-based gene therapy,non-viral gene delivery system has been developed and investigated due to their merits including low immunogenecity,convenient operability,and large-scale manufacturability [1].Because polycations can condense with DNA as a result of electrostatic interactions,form nanosize polyplexes,and protect DNA from degradation by DNase,cationic polymer becomes a major type of non-viral gene delivery vectors (Figure 1) [2].A wide range of polymeric vectors have been developed and investigated in the past decade,such as polyethylenimine (PEI)-based vectors,poly(L-lysine) (PLL)-based vectors,dendrimer-based vectors,polypeptide-based vectors,and chitosan-based vectors [3].However,unlike viral vectors that have the ability to infect host cells and overcome cellular barriers through the course of evolution,nonviral gene vectors exhibit Significantly reduced transfection efficiency as they are obstructed by various extra- and intracellular barriers,including serum proteins in blood stream,cell membrane,endosomal compartment and nuclear membrane [4].

  7. The vector BPS Skyrme model

    CERN Document Server

    Adam, C; Sanchez-Guillen, J; Wereszczynski, A

    2012-01-01

    We analyze the vector meson formulation of the BPS Skyrme model in (3+1) dimensions, where the term of sixth power in first derivatives characteristic for the original, integrable BPS Skyrme model (the topological or baryon current squared) is replaced by a coupling between the vector meson $\\omega_\\mu$ and the baryon current. We find that the model remains integrable in the sense of generalized integrability and almost solvable (reducible to a set of two first order ODEs) for any value of the baryon charge. Further, we analyze the appearance of topological solitons for two one-parameter families of one vacuum potentials: the old Skyrme potentials and the so-called BPS potentials. Depending on the value of the parameters we find several qualitatively different possibilities. In the massless case we have a parameter region with no skyrmions, a unique compact skyrmion with a discontinuous first derivative at the boundary (equivalently, with a source term located at the boundary, which screens the topological ch...

  8. Coexistence and interaction of vector and bound vector solitons in a dispersion-managed fiber laser mode locked by graphene.

    Science.gov (United States)

    Song, Y F; Zhang, H; Zhao, L M; Shen, D Y; Tang, D Y

    2016-01-25

    We report on the experimental observation of vector and bound vector solitons in a fiber laser passively mode locked by graphene. Localized interactions between vector solitons, vector soliton with bound vector solitons, and vector soliton with a bunch of vector solitons are experimentally investigated. We show that depending on the soliton interactions, various stable and dynamic multiple vector soliton states could be formed. PMID:26832559

  9. Overview of vector sensors for undersea applications

    Science.gov (United States)

    McEachern, James F.

    2003-10-01

    An overview of vector sensors for sonar applications is presented. The most prolific use of vector or pressure gradient sensors has been in directional sonobuoys to accomplish effective directional measurements with a sensor that is much smaller than the signal wavelength. Common characteristics, implementation issues, and self noise sources of directional hydrophones are reviewed. Arrays of vector sensors began to emerge in the 1980s and have the attractive property of being able to provide substantially higher directivity for a smaller equivalent aperture than that required for a scalar (omnidirectional) sensor array. Dyadic sensors bring additional directivity but development is required to realize them in a compact configuration. Future applications of vector sensors are discussed. The limited amount of information relative to the ocean acoustic vector fields is noted as a corollary technological requirement for the widespread adoption of vector sensors in sonar systems.

  10. A Modified Moist Ageostrophic Q Vector

    Institute of Scientific and Technical Information of China (English)

    YUE Caijun; SHOU Shaowen

    2008-01-01

    The quasi-geostrophic Q vector is an important diagnostic tool for studying development of surface rainfall associated with large-scale weather systems and is calculated using data at single vertical level. When ageostrophic Q vector was introduced, it required data at two vertical levels. In this study, moist ageostrophic Q vector is modified so that it can be calculated using data at a single vertical level. The comparison study between the original and modified moist ageostrophic Q vectors is conducted using the data from 5 to 6 July 1991 during the torrential rainfall event associated with the Changjiang-Huaihe mei-yu front in China. The results reveal that divergences of original and modified moist ageostrophic Q vectors have similar horizontal distributions and their centers are almost located in the precipitation centers. This indicates that modified moist ageostrophic Q vector can be used to diagnose convective development with reasonable accuracy.

  11. Possible applications for replicating HIV 1 vectors

    OpenAIRE

    Das, Atze T.; Jeeninga, Rienk E.; Berkhout, Ben

    2010-01-01

    Since its discovery some 25 years ago, much has been learned about HIV type 1 and the molecular details of its replication cycle. This insight has been used to develop lentiviral vector systems that have advantages over conventional retroviral vector systems. For safety reasons, the lentiviral vector systems are replication incompetent and the risk of generating a replication competent virus has been minimized. Nevertheless, there may be certain applications for replication competent HIV base...

  12. Viral vectors for vascular gene therapy

    OpenAIRE

    Fischer, Lukas; Preis, Meir; Weisz, Anat; Koren, Belly; Lewis, Basil S; Flugelman, Moshe Y

    2002-01-01

    Vascular gene therapy is the focus of multiple experimental and clinical research efforts. While several genes with therapeutic potential have been identified, the best method of gene delivery is unknown. Viral vectors have the capacity to transfer genes at high efficiency rates. Several viral-based vectors have been used in experimental vascular gene therapy for in vivo and ex vivo gene transfer. Adenoviral-based vectors are being used for the induction of angiogenesis in phase 1 and 2 clini...

  13. Transforming Vectors Measured By Noncoaligned Instruments

    Science.gov (United States)

    Ritter, James R.; Dahlstrom, Eric L.

    1993-01-01

    Method for computing relationships between coordinate axes of two vector-measuring instruments not aligned with each other, one need only measure two nonparallel vectors u and v simultaneously in both coordinate systems. These measurements provide all data needed to compute transformation of any vector from one coordinate system to other. Particularly useful in computing alignments and transformations between accelerometers, gyroscopes, and instruments mounted on platforms subjected to vibrations, thermal strains, and other distortions causing alignments to vary unpredictably with time.

  14. Conformal vector fields on Finsler manifolds

    OpenAIRE

    Szilasi, József; Tóth, Anna

    2011-01-01

    Applying concepts and tools from classical tangent bundle geometry and using the apparatus of the calculus along the tangent bundle projection ('pull-back formalism'), first we enrich the known lists of the characterizations of affine vector fields on a spray manifold and conformal vector fields on a Finsler manifold. Second, we deduce consequences on vector fields on the underlying manifold of a Finsler structure having one or two of the mentioned geometric properties.

  15. Mould Calculus for Hamiltonian Vector Fields

    OpenAIRE

    Cresson, Jacky; Morin, Guillaume

    2008-01-01

    We present the general framework of \\'Ecalle's moulds in the case of linearization of a formal vector field without and within resonances. We enlighten the power of moulds by their universality, and calculability. We modify then \\'Ecalle's technique to fit in the seek of a formal normal form of a Hamiltonian vector field in cartesian coordinates. We prove that mould calculus can also produce successive canonical transformations to bring a Hamiltonian vector field into a normal form. We then p...

  16. Discrete least squares approximation with polynomial vectors

    OpenAIRE

    Van Barel, Marc; Bultheel, Adhemar

    1993-01-01

    We give a solution of a discrete least squares approximation problem in terms of orthogonal polynomial vectors. The degrees of the polynomial elements of these vectors can be different. An algorithm is constructed computing the coefficients of recurrence relations for the orthogonal polynomial vectors. In case the function values are prescribed in points on the real line or on the unit circle variants of the original algorithm can be designed which are an order of magnitude more efficient. Al...

  17. Construction of shRNA lentiviral vector

    Directory of Open Access Journals (Sweden)

    Hong Song

    2010-12-01

    Full Text Available Lentiviruses have been adapted as gene delivery vehicles. This article summarized shRNA lentiviral vector methods generally used in research laboratories. The main procedures of shRNA lentiviral vector include that (1 Target sequences screening and shRNA oligonucleotides designing, (2 insert designed oligonucleotides into lentiviral vectors, (3 using packaging cells to produce shRNA lentivirus, and (4 transducing target cells with shRNA lentivirus.

  18. Genetic manipulation of endosymbionts to control vector and vector borne diseases

    Directory of Open Access Journals (Sweden)

    Jay Prakash Gupta

    Full Text Available Vector borne diseases (VBD are on the rise because of failure of the existing methods of control of vector and vector borne diseases and the climate change. A steep rise of VBDs are due to several factors like selection of insecticide resistant vector population, drug resistant parasite population and lack of effective vaccines against the VBDs. Environmental pollution, public health hazard and insecticide resistant vector population indicate that the insecticides are no longer a sustainable control method of vector and vector-borne diseases. Amongst the various alternative control strategies, symbiont based approach utilizing endosymbionts of arthropod vectors could be explored to control the vector and vector borne diseases. The endosymbiont population of arthropod vectors could be exploited in different ways viz., as a chemotherapeutic target, vaccine target for the control of vectors. Expression of molecules with antiparasitic activity by genetically transformed symbiotic bacteria of disease-transmitting arthropods may serve as a powerful approach to control certain arthropod-borne diseases. Genetic transformation of symbiotic bacteria of the arthropod vector to alter the vector’s ability to transmit pathogen is an alternative means of blocking the transmission of VBDs. In Indian scenario, where dengue, chikungunya, malaria and filariosis are prevalent, paratransgenic based approach can be used effectively. [Vet World 2012; 5(9.000: 571-576

  19. Pro jective vector fields on Finsler manifolds

    Institute of Scientific and Technical Information of China (English)

    TIAN Huang-jia

    2014-01-01

    In this paper, we give the equation that characterizes projective vector fields on a Finsler manifold by the local coordinate. Moreover, we obtain a feature of the projective fields on the compact Finsler manifold with non-positive flag curvature and the non-existence of projective vector fields on the compact Finsler manifold with negative flag curvature. Furthermore, we deduce some expectable, but non-trivial relationships between geometric vector fields such as projective, affine, conformal, homothetic and Killing vector fields on a Finsler manifold.

  20. Vector (two-dimensional) magnetic phenomena

    International Nuclear Information System (INIS)

    In this paper, some interesting phenomena were described from the viewpoint of two-dimensional magnetic property, which is reworded with the vector magnetic property. It shows imperfection of conventional magnetic property and some interested phenomena were discovered, too. We found magnetic materials had the strong nonlinearity both magnitude and spatial phase due to the relationship between the magnetic field strength H-vector and the magnetic flux density B-vector. Therefore, magnetic properties should be defined as the vector relationship. Furthermore, the new Barukhausen signal was observed under rotating flux. (Author)

  1. Vector perturbations of galaxy number counts

    CERN Document Server

    Durrer, Ruth

    2016-01-01

    We derive the contribution to relativistic galaxy number count fluctuations from vector and tensor perturbations within linear perturbation theory. Our result is consistent with the the relativistic corrections to number counts due to scalar perturbation, where the Bardeen potentials are replaced with line-of-sight projection of vector and tensor quantities. Since vector and tensor perturbations do not lead to density fluctuations the standard density term in the number counts is absent. We apply our results to vector perturbations which are induced from scalar perturbations at second order and give numerical estimates of their contributions to the power spectrum of relativistic galaxy number counts.

  2. Hermite normal forms and $\\delta$-vector

    OpenAIRE

    Hibi, Takayuki; Higashitani, Akihiro; Li, Nan

    2010-01-01

    Let $\\delta(\\Pc) = (\\delta_0, \\delta_1,..., \\delta_d)$ be the $\\delta$-vector of an integral polytope $\\Pc \\subset \\RR^N$ of dimension $d$. Following the previous work of characterizing the $\\delta$-vectors with $\\sum_{i=0}^d \\delta_i \\leq 3$, the possible $\\delta$-vectors with $\\sum_{i=0}^d \\delta_i = 4$ will be classified. And each possible $\\delta$-vectors can be obtained by simplices. We get this result by studying the problem of classifying the possible integral simplices with a given $\\...

  3. An elusive vector dark matter

    Directory of Open Access Journals (Sweden)

    Chuan-Ren Chen

    2015-02-01

    Full Text Available Even though the sensitivity of direct dark matter search experiments reaches the level of about 10−45 cm2, no confident signal of dark matter has been observed. We point out that, if dark matter is a vector boson, the null result in direct dark matter search experiments may be due to the destructive effects in dark-matter–nucleon elastic scattering. We illustrate the scenario using a modified Higgs portal model that includes exotic quarks. The significant cancellation can occur for a certain mass gap between new heavy quark and dark matter. As a result, the spin-independent dark-matter–nucleon elastic scattering is so suppressed that the future direct search experiments will hardly observe the signal of dark matter.

  4. Vector Boson Scattering at ATLAS

    CERN Document Server

    Ozcan, V E

    2009-01-01

    While the Higgs model is the best studied scenario of electroweak symmetry breaking, there is no fundamental reason for the physics responsible for the symmetry breaking to be weakly-coupled. Many alternatives exist, predicting highly model-dependent signatures. By measuring the cross-section for the W and Z scattering at the LHC, it will be possible to obtain model-independent evidence for strong symmetry breaking or to constrain these various models. ATLAS Collaboration has recently performed a realistic simulation of this process and its backgrounds, which takes into account the detector effects and has developed new jet-analysis techniques for identifying vector bosons within the immense QCD backgrounds expected at the LHC. These techniques and the prospects for measuring the scattering signal will be presented.

  5. Differentially Private Support Vector Machines

    CERN Document Server

    Sarwate, Anand; Monteleoni, Claire

    2009-01-01

    This paper addresses the problem of practical privacy-preserving machine learning: how to detect patterns in massive, real-world databases of sensitive personal information, while maintaining the privacy of individuals. Chaudhuri and Monteleoni (2008) recently provided privacy-preserving techniques for learning linear separators via regularized logistic regression. With the goal of handling large databases that may not be linearly separable, we provide privacy-preserving support vector machine algorithms. We address general challenges left open by past work, such as how to release a kernel classifier without releasing any of the training data, and how to tune algorithm parameters in a privacy-preserving manner. We provide general, efficient algorithms for linear and nonlinear kernel SVMs, which guarantee $\\epsilon$-differential privacy, a very strong privacy definition due to Dwork et al. (2006). We also provide learning generalization guarantees. Empirical evaluations reveal promising performance on real and...

  6. Deep Support Vector Machines for Regression Problems

    NARCIS (Netherlands)

    Wiering, Marco; Schutten, Marten; Millea, Adrian; Meijster, Arnold; Schomaker, Lambertus

    2013-01-01

    In this paper we describe a novel extension of the support vector machine, called the deep support vector machine (DSVM). The original SVM has a single layer with kernel functions and is therefore a shallow model. The DSVM can use an arbitrary number of layers, in which lower-level layers contain su

  7. CLASSIFICATION OF CUBIC PARAMETERIZED HOMOGENEOUS VECTOR FIELDS

    Institute of Scientific and Technical Information of China (English)

    KamalH.Yasir; TNAGYun

    2002-01-01

    In this paper the cubic homogeneous parameterized vector fields are studied.The classification of the phase portrait near the critical point is presented.This classification is an extension of the result given by takens to the cubic homogeneous parameterized vector fields with six parameters.

  8. CLASSIFICATION OF CUBIC PARAMETERIZED HOMOGENEOUS VECTOR FIELDS

    Institute of Scientific and Technical Information of China (English)

    Karnal H.Yasir; TANG Yun

    2002-01-01

    In this paper the cubic homogeneous parameterized vector fields are studied.The classification of the phase portrait near the critical point is presented. This classification is an extension of the result given by Takens to the cubic homogeneous parameterized vector fields with six parameters.

  9. Vector particles tunneling from BTZ black holes

    CERN Document Server

    Chen, Ge-Rui; Huang, Yong-Chang

    2014-01-01

    In this paper we investigate vector particles' Hawking radiation from a BTZ black hole. By applying the WKB approximation and the Hamilton-Jacobi Ansatz to the Proca equation, we obtain the tunneling spectrum of vector particles. The expected Hawking temperature is recovered.

  10. Vector particles tunneling from BTZ black holes

    Science.gov (United States)

    Chen, Ge-Rui; Zhou, Shiwei; Huang, Yong-Chang

    2015-11-01

    In this paper we investigate vector particles' Hawking radiation from a Banados-Teitelboim-Zanelli (BTZ) black hole. By applying the Wentzel-Kramers-Brillouin (WKB) approximation and the Hamilton-Jacobi ansatz to the Proca equation, we obtain the tunneling spectrum of vector particles. The expected Hawking temperature is recovered.

  11. Increasing the Efficacy of Oncolytic Adenovirus Vectors

    Directory of Open Access Journals (Sweden)

    William S. M. Wold

    2010-08-01

    Full Text Available Oncolytic adenovirus (Ad vectors present a new modality to treat cancer. These vectors attack tumors via replicating in and killing cancer cells. Upon completion of the vector replication cycle, the infected tumor cell lyses and releases progeny virions that are capable of infecting neighboring tumor cells. Repeated cycles of vector replication and cell lysis can destroy the tumor. Numerous Ad vectors have been generated and tested, some of them reaching human clinical trials. In 2005, the first oncolytic Ad was approved for the treatment of head-and-neck cancer by the Chinese FDA. Oncolytic Ads have been proven to be safe, with no serious adverse effects reported even when high doses of the vector were injected intravenously. The vectors demonstrated modest anti-tumor effect when applied as a single agent; their efficacy improved when they were combined with another modality. The efficacy of oncolytic Ads can be improved using various approaches, including vector design, delivery techniques, and ancillary treatment, which will be discussed in this review.

  12. Vector optimization with cone semilocally preinvex functions

    Directory of Open Access Journals (Sweden)

    Surjeet Kaur Suneja

    2014-01-01

    Full Text Available In this paper we introduce cone semilocally preinvex, cone semilocally quasi preinvex and cone semilocally pseudo preinvex functions and study their properties. These functions are further used to establish necessary and sufficient optimality conditions for a vector minimization problem over cones. A Mond-Weir type dual is formulated for the vector optimization problem and various duality theorems are proved.

  13. Application of Vectors to Relative Velocity

    Science.gov (United States)

    Tin-Lam, Toh

    2004-01-01

    The topic 'relative velocity' has recently been introduced into the Cambridge Ordinary Level Additional Mathematics syllabus under the application of Vectors. In this note, the results of relative velocity and the 'reduction to rest' technique of teaching relative velocity are derived mathematically from vector algebra, in the hope of providing…

  14. Clustering Categories in Support Vector Machines

    DEFF Research Database (Denmark)

    Carrizosa, Emilio; Nogales-Gómez, Amaya; Morales, Dolores Romero

    2016-01-01

    The support vector machine (SVM) is a state-of-the-art method in supervised classification. In this paper the Cluster Support Vector Machine (CLSVM) methodology is proposed with the aim to increase the sparsity of the SVM classifier in the presence of categorical features, leading to a gain in in...

  15. 40 CFR 240.206 - Vectors.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Vectors. 240.206 Section 240.206 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.206 Vectors....

  16. Vector Knowledge of Beginning Physics Students.

    Science.gov (United States)

    Knight, Randall D.

    1995-01-01

    Presents the Vector Knowledge Test that was designed to see if beginning physics students possess the minimal basic knowledge of vectors that will allow them to proceed with a study of Newtonian mechanics. Concludes that only one-third of the students in a calculus-based introductory course at California Polytechnic had sufficient vector…

  17. Vector fields and differential operators: noncommutative case

    International Nuclear Information System (INIS)

    A notion of Cartan pairs as an analogy of vector fields in the realm of noncommutative geometry has been proposed previously. In this paper an outline is given of the construction of a noncommutative analogy of the algebra of differential operators as well as its (algebraic) Fock space realization. Co-universal vector fields and covariant derivatives will also be discussed

  18. Symmetric Distributions for Dependent Unit Vectors

    OpenAIRE

    Rivest, Louis-Paul

    1984-01-01

    This paper introduces several notions of symmetry for the joint distribution of two dependent unit vectors. Bivariate generalizations of $\\mathscr{L}$-symmetry (Rivest, 1984) and rotational symmetry are introduced. If the joint distribution of two unit vectors is at least $\\mathscr{L}$-symmetric the information matrix for the parameters indexing it is shown to have a simple shape.

  19. Vectorization of nuclear codes 88-1

    International Nuclear Information System (INIS)

    In this report, we describe the vectorization of thermal reactor standard neutronics code system SRAC, three dimensional neutron diffusion code CITATION, two dimensional discrete ordinates transport code TWOTRAN-II, multi-dimensional core burn-up calculation code COREBN, two and three dimensional neutron diffusion code CITATION-FBR. CITATION code, TWOTRAN code, collision probability method code PIJ in SRAC system are also vectorized. The performance ratio of the vectorized version to the original one is from 1.8 to 8.6 for SRC, from 2.3 to 10.1 for CITATION, 4.2 for TWOTRAN-II, from 2.9 to 10.4 for COREBN, from 3.9 to 13.3 for CITATION-FBR. In this report, we describe sample input data, summary of the codes, vectorization techniques and performance evaluation of the vectorized codes. (author)

  20. Axial Vector $Z'$ and Anomaly Cancellation

    CERN Document Server

    Ismail, Ahmed; Tsao, Kuo-Hsing; Unwin, James

    2016-01-01

    Whilst the prospect of new $Z'$ gauge bosons with only axial couplings to the Standard Model (SM) fermions is widely discussed, examples of anomaly-free renormalisable models are lacking in the literature. We look to remedy this by constructing several motivated examples. Specifically, we consider axial vectors which couple universally to all SM fermions, as well as those which are generation-specific, leptophilic, and leptophobic. Anomaly cancellation typically requires the presence of new coloured and charged chiral fermions, and we argue that the masses of these new states must generally be comparable to that of the axial vector. Finally, an axial vector mediator could provide a portal between SM and hidden sector states, and we also consider the possibility that the axial vector couples to dark matter. If the dark matter relic density is set due to freeze-out via the axial vector, this strongly constrains the parameter space.

  1. Cascade Support Vector Machines with Dimensionality Reduction

    Directory of Open Access Journals (Sweden)

    Oliver Kramer

    2015-01-01

    Full Text Available Cascade support vector machines have been introduced as extension of classic support vector machines that allow a fast training on large data sets. In this work, we combine cascade support vector machines with dimensionality reduction based preprocessing. The cascade principle allows fast learning based on the division of the training set into subsets and the union of cascade learning results based on support vectors in each cascade level. The combination with dimensionality reduction as preprocessing results in a significant speedup, often without loss of classifier accuracies, while considering the high-dimensional pendants of the low-dimensional support vectors in each new cascade level. We analyze and compare various instantiations of dimensionality reduction preprocessing and cascade SVMs with principal component analysis, locally linear embedding, and isometric mapping. The experimental analysis on various artificial and real-world benchmark problems includes various cascade specific parameters like intermediate training set sizes and dimensionalities.

  2. The Geometry of Tangent Bundles: Canonical Vector Fields

    Directory of Open Access Journals (Sweden)

    Tongzhu Li

    2013-01-01

    Full Text Available A canonical vector field on the tangent bundle is a vector field defined by an invariant coordinate construction. In this paper, a complete classification of canonical vector fields on tangent bundles, depending on vector fields defined on their bases, is obtained. It is shown that every canonical vector field is a linear combination with constant coefficients of three vector fields: the variational vector field (canonical lift, the Liouville vector field, and the vertical lift of a vector field on the base of the tangent bundle.

  3. Geoacoustic inversion using the vector field

    Science.gov (United States)

    Crocker, Steven E.

    The main goal of this project was to study the use of the acoustic vector field, separately or in combination with the scalar field, to estimate the depth dependent geoacoustic properties of the seafloor via non-linear inversion. The study was performed in the context of the Sediment Acoustics Experiment 2004 (SAX04) conducted in the Northern Gulf of Mexico (GOM) where a small number of acoustic vector sensors were deployed in close proximity to the seafloor. A variety of acoustic waveforms were transmitted into the seafloor at normal incidence. The acoustic vector sensors were located both above and beneath the seafloor interface where they measured the acoustic pressure and the acoustic particle acceleration. Motion data provided by the buried vector sensors were affected by a suspension response that was sensitive to the mass properties of the sensor, the sediment density and sediment elasticity (e.g., shear wave speed). The suspension response for the buried vector sensors included a resonance within the analysis band of 0.4 to 2.0 kHz. The suspension resonance represented an unknown complex transfer function between the acoustic vector field in the seabed and data representing that field. Therefore, inverse methods developed for this study were required to 1) estimate dynamic properties of the sensor suspension resonance and 2) account for the associated corruption of vector field data. A method to account for the vector sensor suspense response function was integrated directly into the inversion methods such that vector channel data corruption was reduced and an estimate of the shear wave speed in the sediment was returned. Inversions of real and synthetic data sets indicated that information about sediment shear wave speed was carried by the suspension response of the buried sensors, as opposed to being contained inherently within the acoustic vector field.

  4. Students' difficulties with unit vectors and scalar multiplication of a vector

    Science.gov (United States)

    Barniol, Pablo; Zavala, Genaro

    2012-02-01

    In this article we report an investigation on students' understanding of: 1) unit vectors and, 2) scalar multiplication of a vector. We administered two different tests to a total of 850 students after taking their first introductory physics course on mechanics at a large private Mexican university. The first test about unit vectors was taken by 270 students and the second test about scalar multiplication of a vector by 580 students. In the first part of this article, we analyze students' difficulties sketching the unit vector in the direction of a vector in the Cartesian coordinate plane. In the second part, we analyze students' responses in two types of problems: positive and negative scalar multiplication of a vector. In both parts of this article we describe frequent errors that have not been reported in the literature.

  5. GRASS GIS Vector Processing: Towards GRASS 7

    Science.gov (United States)

    Metz, Markus; Landa, Martin; Petrasova, Anna; Petras, Vaclav; Chemin, Yann; Neteler, Markus

    2014-05-01

    The upcoming GRASS GIS 7 release improves not only raster processing and general design but the vector processing in the first place. GRASS GIS, as a topological GIS, recognizes that the topology plays the key role in the vector processing and analysis. Topology ensures that adjacent geographic components in a single vector map are related. In contrast to non-topological GIS, a border common to two areas exists only once and is shared between the two areas. Topological representation of vector data helps to produce and maintain vector maps with clean geometry as well as enables the user to perform certain analyses that can not be conducted with non-topological or spaghetti data. Non-topological vector data are automatically converted to a topological representation upon import. Further more, various cleaning tools exist to remove non-trivial topological errors. In the upcoming GRASS GIS 7 release the vector library was particularly improved to make it faster and more efficient with an improved internal vector file format. This new topological format reduces memory and disk space requirements, leading to a generally faster processing. Opening an existing vector requires less memory providing additionally support for large files. The new spatial index performs queries faster (compared to GRASS GIS 6 more than 10 times for large vectors). As a new option the user can select a file-based version of the spatial index for large vector data. All topological cleaning tools have been optimized with regard to processing speed, robustness, and system requirements. The topological engine comes with a new prototype for direct read/write support of Simple Features API/OGR. Additionally vector data can be directly exchanged with topological PostGIS 2 databases. Considering the wide spread usage of ESRI Shapefile, a non-topological format for vector data exchange, it is particularly advantageous that GRASS GIS 7 offers advanced cleaning tools. For power users and programmers, the

  6. Targeting gene therapy vectors to CNS malignancies.

    Science.gov (United States)

    Spear, M A; Herrlinger, U; Rainov, N; Pechan, P; Weissleder, R; Breakefield, X O

    1998-04-01

    Gene therapy offers significant advantages to the field of oncology with the addition of specifically and uniquely engineered mechanisms of halting malignant proliferation through cytotoxicity or reproductive arrest. To confer a true benefit to the therapeutic ratio (the relative toxicity to tumor compared to normal tissue) a vector or the transgene it carries must selectively affect or access tumor cells. Beyond the selective toxicities of many transgene products, which frequently parallel that of contemporary chemotherapeutic agents, lies the potential utility of targeting the vector. This review presents an overview of current and potential methods for designing vectors targeted to CNS malignancies through selective delivery, cell entry, transport or transcriptional regulation. The topic of delivery encompasses physical and pharmaceutic means of increasing the relative exposure of tumors to vector. Cell entry based methodologies are founded on increasing relative uptake of vector through the chemical or recombinant addition of ligand and antibody domains which selectively bind receptors expressed on target cells. Targeted transport involves the potential for using cells to selectively carry vectors or transgenes into tumors. Finally, promoter and enhancer systems are discussed which have potential for selectivity activating transcription to produce targeted transgene expression or vector propagation. PMID:9584951

  7. Foamy Virus Vectors for HIV Gene Therapy

    Directory of Open Access Journals (Sweden)

    Grant D. Trobridge

    2013-10-01

    Full Text Available Highly active antiretroviral therapy (HAART has vastly improved outcomes for patients infected with HIV, yet it is a lifelong regimen that is expensive and has significant side effects. Retroviral gene therapy is a promising alternative treatment for HIV/AIDS; however, inefficient gene delivery to hematopoietic stem cells (HSCs has so far limited the efficacy of this approach. Foamy virus (FV vectors are derived from non-pathogenic viruses that are not endemic to the human population. FV vectors have been used to deliver HIV-inhibiting transgenes to human HSCs, and they have several advantages relative to other retroviral vectors. These include an attractive safety profile, broad tropism, a large transgene capacity, and the ability to persist in quiescent cells. In addition, the titers of FV vectors are not reduced by anti-HIV transgenes that affect the production of lentivirus (LV vectors. Thus FV vectors are very promising for anti-HIV gene therapy. This review covers the advantages of FV vectors and describes their preclinical development for anti-HIV gene therapy.

  8. The Representation of a Broadband Vector Field

    Institute of Scientific and Technical Information of China (English)

    Qunyan Ren; Jean Pierre Hermand; Shengchun Piao

    2011-01-01

    Compared to a scalar pressure sensor,a vector sensor can provide a higher signal-to-noise ratio (SNR)signal and more detailed information on the sound field.Study on vector sensors and their applications have become a hot topic.Research on the representation of a vector field is highly relevant for extending the scope of vector sensor technology.This paper discusses the range-frequency distribution of the vector field due to a broadband acoustic source moving in a shallow-water waveguide as the self noise of a surface ship,and the vector extension of the waveguide impulse response measured over a limited frequency range using an active source of known waveform.From theory analysis and numerical simulation,the range-frequency representation of a vector field exhibits an interference structure qualitatively similar to that of the corresponding pressure field but,being quantitatively different,provides additional information on the waveguide,especially through the vertical component.For the range-frequency representation,physical quantities that can better exhibit the interference characteristics of the waveguide are the products of pressure and particle velocity and of the pressure and pressure gradient.An image processing method to effectively detect and isolate the individual striations from an interference structure was reviewed briefly.The representation of the vector impulse response was discussed according to two different measurement systems,also known as particle velocity and pressure gradient.The vector impulse response representation can not only provide additional information from pressure only but even more than that of the range-frequency representation.

  9. The standardised freight container: vector of vectors and vector-borne diseases.

    Science.gov (United States)

    Reiter, P

    2010-04-01

    The standardised freight container was one of the most important innovations of the 20th Century. Containerised cargoes travel from their point of origin to their destination by ship, road and rail as part of a single journey, without unpacking. This simple concept is the key element in cheap, rapid transport by land and sea, and has led to a phenomenal growth in global trade. Likewise, containerised air cargo has led to a remarkable increase in the inter-continental transportation of goods, particularly perishable items such as flowers, fresh vegetables and live animals. In both cases, containerisation offers great advantages in speed and security, but reduces the opportunity to inspect cargoes in transit. An inevitable consequence is the globalisation of undesirable species of animals, plants and pathogens. Moreover, cheap passenger flights offer worldwide travel for viral and parasitic pathogens in infected humans. The continued emergence of exotic pests, vectors and pathogens throughout the world is an unavoidable consequence of these advances in transportation technology. PMID:20617647

  10. Efficient than a Nonlentiviral Vector

    Directory of Open Access Journals (Sweden)

    Tao Yang

    2010-01-01

    Full Text Available Background. Lentiviral constructs reportedly can integrate into the genome of non-dividing, terminally differentiated cells and dividing cells, for long-term gene expression. This investigation tested whether a third generation lentiviral-mediated small interfering RNA (siRNA delivered into renal epithelial and fibroblast cells against type II transforming growth factor-beta receptor (siRNA-TBRII could better attenuate renal fibrogenesis in comparison with a non-lentiviral construct. Methods. HIV-derived lentiviral and non-lentiviral constructs were used to transfect cells with siRNA-TBRII or siRNA-EGFP control. Human embryonic kidney (HEK-293T, renal epithelial cells (NRK-52E and renal fibroblasts (NRK-49F were transfected and gene silencing quantified (fluorescence microscopy, Western blotting, fluorescence-activated cell sorting. Renal fibrogenesis was assessed using extracellular matrix protein synthesis (fibronectin and collagen-III; Western immunoblot, and α-smooth muscle actin (α-SMA was analysed as a marker of fibroblast activation and epithelial-to-mesenchymal transdifferentiation (EMT. Results. Lentiviral-mediated siRNA-TBRII significantly suppressed TBRII expression in all cell lines, and also significantly suppressed renal fibrogenesis. In comparison with the non-lentiviral construct, lentiviral-mediated siRNA-TBRII produced stronger and more persistent inhibition of collagen-III in NRK-49F cells, fibronectin in all renal cell lines, and α-SMA in renal epithelial cells. Conclusions. Lentiviral vector systems against TBRII can be delivered into renal cells to efficiently limit renal fibrogenesis by sequence-specific gene silencing.

  11. Phase interaction of short vector solitons

    International Nuclear Information System (INIS)

    An interaction of vector solitons in the frame of coupled third-order nonlinear Schrödinger equations taking into account third-order linear dispersion, nonlinear dispersion, and cross-phase modulation terms is considered. Phase nature of the solitons' interaction is shown. In particular, dependence of solitons' trajectories on initial distance between solitons is shown. Conditions of reflection and propagation of solitons through each other are obtained. -- Highlights: ► Short vector soliton's interaction in the frame of CTNSE without SRS is studied. ► Analytical and numerical approaches are considered. ► Phase effects lead to short vector soliton's interaction character change.

  12. 600-GHz Electronically Tunable Vector Measurement System

    Science.gov (United States)

    Dengler, Robert; Maiwald, Frank; Siegel, Peter

    2007-01-01

    A compact, high-dynamic-range, electronically tunable vector measurement system that operates in the frequency range from approximately 560 to approximately 635 GHz has been developed as a prototype of vector measurement systems that would be suitable for use in nearly-real-time active submillimeter-wave imaging. As used here, 'vector measurement system" signifies an instrumentation system that applies a radio-frequency (RF) excitation to an object of interest and measures the resulting amplitude and phase response, relative to either the applied excitatory signal or another reference signal related in a known way to applied excitatory signal.

  13. Two Layer Vector Quantization of Images

    Directory of Open Access Journals (Sweden)

    V. Michalcin

    2001-06-01

    Full Text Available This paper deals with spatial scaleable vector quantization ofimages by using two layers. At the base layer the small dimensionalfull search vector quantization of an image of block means is carriedout. After subtracting it from the input image at the enhancement layerthe difference of full spatial resolution is quantized by largedimensional weighted pyramid vector quantizer in transform domain.Experimental results demonstrate acceptable quality of the downscaledimage from the output of base layer at very low bit rate andpossibility of next increasing its quality by the upscaled differenceimage from the output of enhancement layer.

  14. Nonlinear singular vectors and nonlinear singular values

    Institute of Scientific and Technical Information of China (English)

    穆穆

    2000-01-01

    A novel concept of nonlinear singular vector and nonlinear singular value is introduced, which is a natural generalization of the classical linear singular vector and linear singular value to the nonlinear category. The optimization problem related to the determination of nonlinear singular vectors and singular values is formulated. The general idea of this approach is demonstrated by a simple two-dimensional quasigeostrophic model in the atmospheric and oceanic sciences. The advantage and its applications of the new method to the predictability, ensemble forecast and finite-time nonlinear instability are discussed. This paper makes a necessary preparation for further theoretical and numerical investigations.

  15. Weak equivalence classes of complex vector bundles

    OpenAIRE

    Hông-Vân Lê

    2006-01-01

    For any complex vector bundle Ek of rank k over a manifold Mm with Chern classes ci Î H2i(Mm, Z) and any non-negative integers l1, . . ., lk we show the existence of a positive number p(m, k) and the existence of a complex vector bundle Êk over Mm whose Chern classes are p(m, k) × li × ci Î H2i(Mm, Z). We also discuss a version of this statement for holomorphic vector bundles over projective algebraic manifolds.

  16. A NEW HYPERSPHERE SUPPORT VECTOR MACHINE ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Zhang Xinfeng; Shen Lansun

    2006-01-01

    The hypersphere support vector machine is a new algorithm in pattern recognition. By studying three kinds ofhypersphere support vector machines, it is found that their solutions are identical and the margin between two classes of samples is zero or is not unique. In this letter, a new kind ofhypersphere support vector machine is proposed. By introducing a parameter n(n>l), a unique solution of the margin can be obtained.Theoretical analysis and experimental results show that the proposed algorithm can achieve better generalization performance.

  17. Development of Multigene and Regulated Lentivirus Vectors

    OpenAIRE

    Reiser, Jakob; Lai, Zhennan; Zhang, Xian-Yang; Brady, Roscoe O.

    2000-01-01

    Previously we described safe and efficient three-component human immunodeficiency virus type 1 (HIV-1)-based gene transfer systems for delivery of genes into nondividing cells (H. Mochizuki, J. P. Schwartz, K. Tanaka, R. O. Brady, and J. Reiser, J. Virol. 72:8873–8883, 1998). To apply such vectors in anti-HIV gene therapy strategies and to express multiple proteins in single target cells, we have engineered HIV-1 vectors for the concurrent expression of multiple transgenes. Single-gene vector...

  18. Vector supersymmetry in the universal bundle

    International Nuclear Information System (INIS)

    We present a vector supersymmetry for Witten-type topological gauge theories, and examine its algebra in terms of a superconnection formalism. When covariant constraints on the supercurvature are chosen, a correspondence is established with the universal bundle construction of Atiyah and Singer. The vector supersymmetry represents a certain shift operator in the curvature of the universal bundle, and can be used to generate the hierarchy of observables in these theories. This formalism should lead to the construction of vector supergravity theories, and perhaps to the gravitational analogue of the universal bundle. (orig.)

  19. Robust Pseudo-Hierarchical Support Vector Clustering

    DEFF Research Database (Denmark)

    Hansen, Michael Sass; Sjöstrand, Karl; Olafsdóttir, Hildur;

    2007-01-01

    for calculating the entire regularization path of the support vector domain description, we propose a fast method for robust pseudo-hierarchical support vector clustering (HSVC). The method is demonstrated to work well on generated data, as well as for detecting ischemic segments from multidimensional myocardial......Support vector clustering (SVC) has proven an efficient algorithm for clustering of noisy and high-dimensional data sets, with applications within many fields of research. An inherent problem, however, has been setting the parameters of the SVC algorithm. Using the recent emergence of a method...

  20. New Anomaly of the Axial-Vector Current

    Institute of Scientific and Technical Information of China (English)

    HE Han-Xin

    2001-01-01

    By computing the axial-vector current operator equation, we find the anomalous axial-vector curl equation besides the well-known anomalous axial-vector divergence equation (the Adler-Bell-Jackiw anomaly) and discuss its implication.``

  1. Vectorization, parallelization and porting of nuclear codes (vectorization and parallelization). Progress report fiscal 1998

    International Nuclear Information System (INIS)

    Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system, the AP3000 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 12 codes in fiscal 1998. These results are reported in 3 parts, i.e., the vectorization and parallelization on vector processors part, the parallelization on scalar processors part and the porting part. In this report, we describe the vectorization and parallelization on vector processors. In this vectorization and parallelization on vector processors part, the vectorization of General Tokamak Circuit Simulation Program code GTCSP, the vectorization and parallelization of Molecular Dynamics NTV (n-particle, Temperature and Velocity) Simulation code MSP2, Eddy Current Analysis code EDDYCAL, Thermal Analysis Code for Test of Passive Cooling System by HENDEL T2 code THANPACST2 and MHD Equilibrium code SELENEJ on the VPP500 are described. In the parallelization on scalar processors part, the parallelization of Monte Carlo N-Particle Transport code MCNP4B2, Plasma Hydrodynamics code using Cubic Interpolated Propagation Method PHCIP and Vectorized Monte Carlo code (continuous energy model / multi-group model) MVP/GMVP on the Paragon are described. In the porting part, the porting of Monte Carlo N-Particle Transport code MCNP4B2 and Reactor Safety Analysis code RELAP5 on the AP3000 are described. (author)

  2. Vectorization, parallelization and porting of nuclear codes (vectorization and parallelization). Progress report fiscal 1998

    Energy Technology Data Exchange (ETDEWEB)

    Ishizuki, Shigeru; Kawai, Wataru; Nemoto, Toshiyuki [Fujitsu Ltd., Tokyo (Japan); Ogasawara, Shinobu; Kume, Etsuo; Adachi, Masaaki; Kawasaki, Nobuo [Center for Promotion of Computational Science and Engineering (Tokai Site), Japan Atomic Energy Research Institute, Tokai, Ibaraki (Japan); Yatake, Yo-ichi [Hitachi Ltd., Tokyo (Japan)

    2000-03-01

    Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system, the AP3000 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 12 codes in fiscal 1998. These results are reported in 3 parts, i.e., the vectorization and parallelization on vector processors part, the parallelization on scalar processors part and the porting part. In this report, we describe the vectorization and parallelization on vector processors. In this vectorization and parallelization on vector processors part, the vectorization of General Tokamak Circuit Simulation Program code GTCSP, the vectorization and parallelization of Molecular Dynamics NTV (n-particle, Temperature and Velocity) Simulation code MSP2, Eddy Current Analysis code EDDYCAL, Thermal Analysis Code for Test of Passive Cooling System by HENDEL T2 code THANPACST2 and MHD Equilibrium code SELENEJ on the VPP500 are described. In the parallelization on scalar processors part, the parallelization of Monte Carlo N-Particle Transport code MCNP4B2, Plasma Hydrodynamics code using Cubic Interpolated Propagation Method PHCIP and Vectorized Monte Carlo code (continuous energy model / multi-group model) MVP/GMVP on the Paragon are described. In the porting part, the porting of Monte Carlo N-Particle Transport code MCNP4B2 and Reactor Safety Analysis code RELAP5 on the AP3000 are described. (author)

  3. Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

    OpenAIRE

    Wold, William S.M.; Toth, Karoly

    2013-01-01

    Adenovirus vectors are the most commonly employed vector for cancer gene therapy. They are also used for gene therapy and as vaccines to express foreign antigens. Adenovirus vectors can be replication-defective; certain essential viral genes are deleted and replaced by a cassette that expresses a foreign therapeutic gene. Such vectors are used for gene therapy, as vaccines, and for cancer therapy. Replication-competent (oncolytic) vectors are employed for cancer gene therapy. Oncolytic vector...

  4. Gamow vectors explain the shock profile.

    Science.gov (United States)

    Braidotti, Maria Chiara; Gentilini, Silvia; Conti, Claudio

    2016-09-19

    The description of shock waves beyond the shock point is a challenge in nonlinear physics and optics. Finding solutions to the global dynamics of dispersive shock waves is not always possible due to the lack of integrability. Here we propose a new method based on the eigenstates (Gamow vectors) of a reversed harmonic oscillator in a rigged Hilbert space. These vectors allow analytical formulation for the development of undular bores of shock waves in a nonlinear nonlocal medium. Experiments by a photothermal induced nonlinearity confirm theoretical predictions: the undulation period as a function of power and the characteristic quantized decays of Gamow vectors. Our results demonstrate that Gamow vectors are a novel and effective paradigm for describing extreme nonlinear phenomena. PMID:27661931

  5. Vectorization and improvement of nuclear codes, (2)

    International Nuclear Information System (INIS)

    Two nuclear codes, three dimensional thermal hydraulic analysis code 'SPARKLE' and two dimensional disruption thermal analysis code 'DREAM', have been vectorized. The Cray version of high energy radiation Monte Carlo elaborate system 'HERMES' has been converted to the Fujitsu MSP version. Reactor safety Analysis code 'RELAP5/MOD3' has been modified to assign its variables to the extended memory area of Fujitsu MSP operating system. We have obtained the speedup of 4.1-4.8 and 1.6 for the vectorized SPARKLE and DREAM, respectively, on the Fujitsu VP2600/10 in the vector execution compared with the scalar execution. In this report, outlines of the codes, techniques used in the vectorization and modification of the codes, and their performance are presented. (author)

  6. Students' difficulties with vector calculus in electrodynamics

    CERN Document Server

    Bollen, Laurens; De Cock, Mieke

    2015-01-01

    Understanding Maxwell's equations in differential form is a prerequisite to study the electrodynamic phenomena that are discussed in advanced electromagnetism courses. It is therefore necessary that students master the use of vector calculus in physical situations. In this light we investigated the difficulties second year students at KU Leuven encounter with the divergence and curl of a vector field in mathematical and physical contexts. We have found they are quite skilled at doing calculations, but struggle with interpreting graphical representations of vector fields and applying vector calculus to physical situations. We have found strong indications that traditional instruction is not sufficient for our students to fully understand the meaning and power of Maxwell's equations in electrodynamics.

  7. Generalized Stokes vector for three photon process

    CERN Document Server

    Shaji, Chitra; Satyanarayana, SVM; Sharan, Alok

    2015-01-01

    Stokes Muller formalism is important to understand the optical properties of materials by measuring the change in the polarization state of light upon scattering. The formalism can be extended to nonlinear scattering processes involving two and three photon processes. In this work, we derive a triple Stokes vector analytically using operator approach used in quantum theory of light. A three photon polarization state can be described by Stokes vector that has sixteen components involving cubes of intensities. The response of a material for the scattering of light in a three photon process is described by 4 x 16 Muller matrix. Polarization in Polarization out (PIPO) experiments can be carried out to determine the elements of Muller matrix. For that we identify 16 independent points in Poincare sphere and construct triple Stokes vector for each point. Four measurements to find the linear Stokes vector of the scattered light for incident light in each of the sixteen three photon states determine the Muller matrix...

  8. Horizontal vectorization of electron repulsion integrals.

    Science.gov (United States)

    Pritchard, Benjamin P; Chow, Edmond

    2016-10-30

    We present an efficient implementation of the Obara-Saika algorithm for the computation of electron repulsion integrals that utilizes vector intrinsics to calculate several primitive integrals concurrently in a SIMD vector. Initial benchmarks display a 2-4 times speedup with AVX instructions over comparable scalar code, depending on the basis set. Speedup over scalar code is found to be sensitive to the level of contraction of the basis set, and is best for (lAlB|lClD) quartets when lD  = 0 or lB=lD=0, which makes such a vectorization scheme particularly suitable for density fitting. The basic Obara-Saika algorithm, how it is vectorized, and the performance bottlenecks are analyzed and discussed. © 2016 Wiley Periodicals, Inc. PMID:27620865

  9. Weaving knotted vector fields with tunable helicity

    CERN Document Server

    Kedia, Hridesh; Dennis, Mark R; Irvine, William T M

    2016-01-01

    We present a general construction of divergence-free knotted vector fields from complex scalar fields, whose closed field lines encode many kinds of knots and links, including torus knots, their cables, the figure-8 knot and its generalizations. As finite-energy physical fields they represent initial states for fields such as the magnetic field in a plasma, or the vorticity field in a fluid. We give a systematic procedure for calculating the vector potential, starting from complex scalar functions with knotted zero filaments, thus enabling an explicit computation of the helicity of these knotted fields. The construction can be used to generate isolated knotted flux tubes, filled by knots encoded in the lines of the vector field. Lastly we give examples of manifestly knotted vector fields with vanishing helicity. Our results provide building blocks for analytical models and simulations alike.

  10. Sensorless vector and direct torque control

    CERN Document Server

    Vas, Peter

    1998-01-01

    This is the first comprehensive book on sensorless high performance a.c. drives. It is essential reading for anyone interested in acquiring a solid background on sensorless torque-controlled drives. It presents a detailed and unified treatment of sensorless vector-controlled and direct-torque controlled drive systems. It also discusses the applications of artificial intelligence to drives. Where possible, space vector theory is used and emphasis is laid on detailed mathematical and physical analysis. Sensorless drive schemes for different types of permanent magnet synchronous motors, synchronous reluctance motors, and induction motors are also presented. These include more than twenty vector drives e.g. five types of MRAS-based vector drives, and eleven types of direct-torque-controlled (DTC) drives, e.g. the ABB DTC drive. However, torque-controlled switched reluctance motor drives are also discussed due to their emerging importance. The book also covers various drive applications using artificial intellige...

  11. VEST: Abstract Vector Calculus Simplification in Mathematica

    Energy Technology Data Exchange (ETDEWEB)

    J. Squire, J. Burby and H. Qin

    2013-03-12

    We present a new package, VEST (Vector Einstein Summation Tools), that performs abstract vector calculus computations in Mathematica. Through the use of index notation, VEST is able to reduce scalar and vector expressions of a very general type using a systematic canonicalization procedure. In addition, utilizing properties of the Levi-Civita symbol, the program can derive types of multi-term vector identities that are not recognized by canonicalization, subsequently applying these to simplify large expressions. In a companion paper [1], we employ VEST in the automation of the calculation of Lagrangians for the single particle guiding center system in plasma physics, a computation which illustrates its ability to handle very large expressions. VEST has been designed to be simple and intuitive to use, both for basic checking of work and more involved computations. __________________________________________________

  12. Insects as vectors: systematics and biology.

    Science.gov (United States)

    Rodhain, F

    2015-04-01

    Among the many complex relationships between insects and microorganisms such as viruses, bacteria and parasites, some have resulted in the establishment of biological systems within which the insects act as a biological vector for infectious agents. It is therefore advisable to understand the identity and biology of these vectors in depth, in order to define procedures for epidemiological surveillance and anti-vector control. The following are successively reviewed in this article: Anoplura (lice), Siphonaptera (fleas), Heteroptera (bugs: Cimicidae, Triatoma, Belostomatidae), Psychodidae (sandflies), Simuliidae (black flies), Ceratopogonidae (biting midges), Culicidae (mosquitoes), Tabanidae (horseflies) and Muscidae (tsetse flies, stable flies and pupipara). The authors provide a rapid overview of the morphology, systematics, development cycle and bio-ecology of each of these groups of vectors. Finally, their medical and veterinary importance is briefly reviewed.

  13. Twisted Vector Bundles on Pointed Nodal Curves

    Indian Academy of Sciences (India)

    Ivan Kausz

    2005-05-01

    Motivated by the quest for a good compactification of the moduli space of -bundles on a nodal curve we establish a striking relationship between Abramovich’s and Vistoli’s twisted bundles and Gieseker vector bundles.

  14. VEST: abstract vector calculus simplification in Mathematica

    CERN Document Server

    Squire, Jonathan; Qin, Hong

    2013-01-01

    We present a new package, VEST (Vector Einstein Summation Tools), that performs abstract vector calculus computations in Mathematica. Through the use of index notation, VEST is able to reduce three-dimensional scalar and vector expressions of a very general type to a well defined standard form. In addition, utilizing properties of the Levi-Civita symbol, the program can derive types of multi-term vector identities that are not recognized by reduction, subsequently applying these to simplify large expressions. In a companion paper (Burby et al., 2013), we employ VEST in the automation of the calculation of high-order Lagrangians for the single particle guiding center system in plasma physics, a computation which illustrates its ability to handle very large expressions. VEST has been designed to be simple and intuitive to use, both for basic checking of work and more involved computations.

  15. Low Power, Self Calibrated Vector Magnetometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR project investigates a novel approach to vector magnetometry based on high precision measurements of the total magnetic field. The calibration is...

  16. Positional codes of complex numbers and vectors

    OpenAIRE

    Solomon, I.

    2008-01-01

    A little-known theory of positional coding of complex numbers and vectors is described this theory may be used for the development of specialized processors. The theory is supplemented by numerous examples.

  17. Extracting Road Vector Data from Raster Maps

    Science.gov (United States)

    Chiang, Yao-Yi; Knoblock, Craig A.

    Raster maps are an important source of road information. Because of the overlapping map features (e.g., roads and text labels) and the varying image quality, extracting road vector data from raster maps usually requires significant user input to achieve accurate results. In this paper, we present an accurate road vectorization technique that minimizes user input by combining our previous work on extracting road pixels and road-intersection templates to extract accurate road vector data from raster maps. Our approach enables GIS applications to exploit the road information in raster maps for the areas where the road vector data are otherwise not easily accessible, such as the countries of the Middle East. We show that our approach requires minimal user input and achieves an average of 93.2% completeness and 95.6% correctness in an experiment using raster maps from various sources.

  18. Fractional Vector Calculus and Fractional Special Function

    OpenAIRE

    Li, Ming-Fan; Ren, Ji-Rong; Zhu, Tao

    2010-01-01

    Fractional vector calculus is discussed in the spherical coordinate framework. A variation of the Legendre equation and fractional Bessel equation are solved by series expansion and numerically. Finally, we generalize the hypergeometric functions.

  19. Gamow Vectors Explain the Shock "Batman" Profile

    CERN Document Server

    Braidotti, Maria Chiara; Conti, Claudio

    2016-01-01

    The description of shock waves beyond the shock point is a challenge in nonlinear physics. Finding solutions to the global dynamics of dispersive shock waves is not always possible due to the lack of integrability. Here we propose a new method based on the eigenstates (Gamow vectors) of a reversed harmonic oscillator in a rigged Hilbert space. These vectors allow analytical formulation for the development of undular bores of shock waves in a nonlinear nonlocal medium. Experiments by a photothermal induced nonlinearity confirm theoretical predictions: as the undulation period as a function of power and the characteristic quantized decays of Gamow vectors. Our results demonstrate that Gamow vector are a novel and effective paradigm for describing extreme nonlinear phenomena.

  20. Insects as vectors: systematics and biology.

    Science.gov (United States)

    Rodhain, F

    2015-04-01

    Among the many complex relationships between insects and microorganisms such as viruses, bacteria and parasites, some have resulted in the establishment of biological systems within which the insects act as a biological vector for infectious agents. It is therefore advisable to understand the identity and biology of these vectors in depth, in order to define procedures for epidemiological surveillance and anti-vector control. The following are successively reviewed in this article: Anoplura (lice), Siphonaptera (fleas), Heteroptera (bugs: Cimicidae, Triatoma, Belostomatidae), Psychodidae (sandflies), Simuliidae (black flies), Ceratopogonidae (biting midges), Culicidae (mosquitoes), Tabanidae (horseflies) and Muscidae (tsetse flies, stable flies and pupipara). The authors provide a rapid overview of the morphology, systematics, development cycle and bio-ecology of each of these groups of vectors. Finally, their medical and veterinary importance is briefly reviewed. PMID:26470450

  1. VEST: Abstract vector calculus simplification in Mathematica

    Science.gov (United States)

    Squire, J.; Burby, J.; Qin, H.

    2014-01-01

    We present a new package, VEST (Vector Einstein Summation Tools), that performs abstract vector calculus computations in Mathematica. Through the use of index notation, VEST is able to reduce three-dimensional scalar and vector expressions of a very general type to a well defined standard form. In addition, utilizing properties of the Levi-Civita symbol, the program can derive types of multi-term vector identities that are not recognized by reduction, subsequently applying these to simplify large expressions. In a companion paper Burby et al. (2013) [12], we employ VEST in the automation of the calculation of high-order Lagrangians for the single particle guiding center system in plasma physics, a computation which illustrates its ability to handle very large expressions. VEST has been designed to be simple and intuitive to use, both for basic checking of work and more involved computations.

  2. The light filament as vector solitary wave

    CERN Document Server

    Kovachev, Lubomir M

    2015-01-01

    We present an analytical approach to the theory of nonlinear propagation of femtosecond optical pulses with broad-band spectrum in gases. The vector character of the nonlinear third-order polarization is investigated in details, taking into account the carrier to envelope phase. The corresponding system of vector amplitude equations is written by using left-hand and right-hand circular components of the electrical field. We found that this system nonlinear equations admits $3D+1$ vector soliton solution with Lorentz shape. The solution presents relatively stable propagation and rotation with GHz frequency of the vector of the electrical field in plane, orthogonal to the direction of propagation. The evolution of the intensity profile demonstrate weak self-compression and week spherical wave in the first milliseconds of propagation.

  3. Dynamics of localized structures in vector waves

    CERN Document Server

    Hernández-García, E; Colet, P; San Miguel, M; Hernandez-Garcia, Emilio; Hoyuelos, Miguel; Colet, Pere; Miguel, Maxi San

    1999-01-01

    Dynamical properties of topological defects in a twodimensional complex vector field are considered. These objects naturally arise in the study of polarized transverse light waves. Dynamics is modeled by a Vector Complex Ginzburg-Landau Equation with parameter values appropriate for linearly polarized laser emission. Creation and annihilation processes, and selforganization of defects in lattice structures, are described. We find "glassy" configurations dominated by vectorial defects and a melting process associated to topological-charge unbinding.

  4. Teleparallel Killing Vectors of the Einstein Universe

    OpenAIRE

    M. Sharif; Amir, M. Jamil

    2007-01-01

    In this short paper we establish the definition of the Lie derivative of a second rank tensor in the context of teleparallel theory of gravity and also extend it for a general tensor of rank $p+q$. This definition is then used to find Killing vectors of the Einstein universe. It turns out that Killing vectors of the Einstein universe in the teleparallel theory are the same as in General Relativity.

  5. GEOMAGNETIC ANOMALY FIELD VECTOR OFF WESTERN AUSTRALIA

    OpenAIRE

    ノギ, ヨシフミ; エグチ, ヨシアキ; セアマ, ノブカズ; イセザキ, ノブヒロ; Yoshifumi, NOGI; Yoshiaki, EGUCHI; Nobukazu, SEAMA; Nobuhiro, ISEZAKI

    1993-01-01

    Vector data of the geomagnetic anomaly field were obtained during the 32nd Japanese Antarctic Research Expedition (JARE-32) off Western Australia. The strikes of the magnetic boundaries at their position were derived from vector data of the geomagnetic anomaly field. These strikes were interpreted as the directions of magnetic anomaly lineations originated either by seafloor spreading (seafloor spreading anomaly) or by morphological structures (structural magnetic anomaly). Some strikes of st...

  6. Bacteriophage Lambda as a Cloning Vector

    OpenAIRE

    Chauthaiwale, V M; Therwath, A; Deshpande, V V

    1993-01-01

    Extensive research has been directed toward the development of multipurpose lambda vectors for cloning ever since the potential of using coliphage lambda as a cloning vector was recognized in the late 1970s. An understanding of the intrinsic molecular organization and of the genetic events which determine lysis or lysogeny in lambda has allowed investigators to modify it to suit the specific requirements of gene manipulations. Unwanted restriction sites have been altered and arranged together...

  7. [Orthogonal Vector Projection Algorithm for Spectral Unmixing].

    Science.gov (United States)

    Song, Mei-ping; Xu, Xing-wei; Chang, Chein-I; An, Ju-bai; Yao, Li

    2015-12-01

    Spectrum unmixing is an important part of hyperspectral technologies, which is essential for material quantity analysis in hyperspectral imagery. Most linear unmixing algorithms require computations of matrix multiplication and matrix inversion or matrix determination. These are difficult for programming, especially hard for realization on hardware. At the same time, the computation costs of the algorithms increase significantly as the number of endmembers grows. Here, based on the traditional algorithm Orthogonal Subspace Projection, a new method called. Orthogonal Vector Projection is prompted using orthogonal principle. It simplifies this process by avoiding matrix multiplication and inversion. It firstly computes the final orthogonal vector via Gram-Schmidt process for each endmember spectrum. And then, these orthogonal vectors are used as projection vector for the pixel signature. The unconstrained abundance can be obtained directly by projecting the signature to the projection vectors, and computing the ratio of projected vector length and orthogonal vector length. Compared to the Orthogonal Subspace Projection and Least Squares Error algorithms, this method does not need matrix inversion, which is much computation costing and hard to implement on hardware. It just completes the orthogonalization process by repeated vector operations, easy for application on both parallel computation and hardware. The reasonability of the algorithm is proved by its relationship with Orthogonal Sub-space Projection and Least Squares Error algorithms. And its computational complexity is also compared with the other two algorithms', which is the lowest one. At last, the experimental results on synthetic image and real image are also provided, giving another evidence for effectiveness of the method. PMID:26964231

  8. Insecticide Resistanca in Maleria Vector An. sacharovi

    OpenAIRE

    Üniversitesi, Çukurova; ABD, Tıp Fakültesi Tıbbi Biyoloji; Balcalı,; Adana-TÜRKİYE,

    2000-01-01

    Susceptibility tests have been successfully used for many years to determine insecticide resistance raised in pest and vector insects, including An. sacharovi,the primary human malaria vector in Turkey. As this method does not provide sufficient information about physiological resistance, an alternative method of enzyme tests based on biochemical and genetic evaluations has been developed. In this study, both methods were used for comparison. First of all, susceptibility to insecticides w...

  9. Angular velocity nonlinear observer from vector measurements

    OpenAIRE

    Magnis, Lionel; Petit, Nicolas

    2015-01-01

    The paper proposes a technique to estimate the angular velocity of a rigid body from vector measurements. Compared to the approaches presented in the literature, it does not use attitude information nor rate gyros as inputs. Instead, vector measurements are directly filtered through a nonlinear observer estimating the angular velocity. Convergence is established using a detailed analysis of the linear-time varying dynamics appearing in the estimation error equation. This equation stems from t...

  10. Vector field processing on triangle meshes

    OpenAIRE

    De Goes, Fernando; Desbrun, Mathieu; Tong, Yiying

    2015-01-01

    While scalar fields on surfaces have been staples of geometry processing, the use of tangent vector fields has steadily grown in geometry processing over the last two decades: they are crucial to encoding directions and sizing on surfaces as commonly required in tasks such as texture synthesis, non-photorealistic rendering, digital grooming, and meshing. There are, however, a variety of discrete representations of tangent vector fields on triangle meshes, and each approach offers different tr...

  11. Support Vector Machine Classification with Indefinite Kernels

    OpenAIRE

    Luss, Ronny; d'Aspremont, Alexandre

    2008-01-01

    We propose a method for support vector machine classification using indefinite kernels. Instead of directly minimizing or stabilizing a nonconvex loss function, our algorithm simultaneously computes support vectors and a proxy kernel matrix used in forming the loss. This can be interpreted as a penalized kernel learning problem where indefinite kernel matrices are treated as a noisy observations of a true Mercer kernel. Our formulation keeps the problem convex and relatively large problems ca...

  12. Nonperturbative Aspects of Axial Vector Vertex

    Institute of Scientific and Technical Information of China (English)

    ZONG Hong-Shi; CHEN Xiang-Song; WANG Fan; CHANG Chao-Hsi; ZHAO En-Guang

    2002-01-01

    It is shown how the axial vector current of current quarks is related to that of constituent quarks within the framework of the global color symmetry model.Gluon dressing of the axial vector vertex and the quark self-energy functions are described by the inhomogeneous Bethe-Salpeter equation in the ladder approximation and the Schwinger Dyson equation in the rainbow approximation,respectively.

  13. Proofs of Vector Identities Using Tensors

    OpenAIRE

    Uddin, Zaheer; Ulfat, Intikhab

    2014-01-01

    The vector algebra and calculus are frequently used in many branches of Physics, for example, classical mechanics, electromagnetic theory, Astrophysics, Spectroscopy, etc. Important vector identities with the help of Levi-Civita symbols and Kronecker delta tensor are proved and presented in this paper. Some of the identities have been proved using Levi-Civita Symbols by other mathematicians and Physicists. The rests are presented for the first time. The derivations are of interest for both gr...

  14. Students' difficulties with vector calculus in electrodynamics

    OpenAIRE

    Bollen, Laurens; van Kampen, Paul; De Cock, Mieke

    2015-01-01

    Understanding Maxwell's equations in differential form is of great importance when studying the electrodynamic phenomena discussed in advanced electromagnetism courses. It is therefore necessary that students master the use of vector calculus in physical situations. In this light we investigated the difficulties second year students at KU Leuven encounter with the divergence and curl of a vector field in mathematical and physical contexts. We have found that they are quite skilled at doing ca...

  15. New approach to training support vector machine

    Institute of Scientific and Technical Information of China (English)

    Tang Faming; Chen Mianyun; Wang Zhongdong

    2006-01-01

    Support vector machine has become an increasingly popular tool for machine learning tasks involving classification, regression or novelty detection. Training a support vector machine requires the solution of a very large quadratic programming problem. Traditional optimization methods cannot be directly applied due to memory restrictions. Up to now, several approaches exist for circumventing the above shortcomings and work well. Another learning algorithm, particle swarm optimization, for training SVM is introduted. The method is tested on UCI datasets.

  16. Vector meson contributions in ε'/ε

    International Nuclear Information System (INIS)

    The CP-violating parameter -bar '/-bar is computed using the low-energy dynamics of the chiral theory supplemented by vector resonances. The divergent contributions coming from strong π-π scattering are tamed by vector-meson exchange terms. This amounts to softening the fast growing high-energy behaviour of π-π scattering. The final result for ε'/ε shows a smooth dependence on the cut-off where low energy dynamics is matched with that of QCD

  17. Solving Parity Games on Integer Vectors

    OpenAIRE

    Abdulla, Parosh Aziz; Mayr, Richard; Sangnier, Arnaud; Sproston, Jeremy

    2013-01-01

    We consider parity games on infinite graphs where configurations are represented by control-states and integer vectors. This framework subsumes two classic game problems: parity games on vector addition systems with states (vass) and multidimensional energy parity games. We show that the multidimensional energy parity game problem is inter-reducible with a subclass of single-sided parity games on vass where just one player can modify the integer counters and the opponent can only change contr...

  18. Light scattering of rectangular slot antennas: parallel magnetic vector vs perpendicular electric vector.

    Science.gov (United States)

    Lee, Dukhyung; Kim, Dai-Sik

    2016-01-07

    We study light scattering off rectangular slot nano antennas on a metal film varying incident polarization and incident angle, to examine which field vector of light is more important: electric vector perpendicular to, versus magnetic vector parallel to the long axis of the rectangle. While vector Babinet's principle would prefer magnetic field along the long axis for optimizing slot antenna function, convention and intuition most often refer to the electric field perpendicular to it. Here, we demonstrate experimentally that in accordance with vector Babinet's principle, the incident magnetic vector parallel to the long axis is the dominant component, with the perpendicular incident electric field making a small contribution of the factor of 1/|ε|, the reciprocal of the absolute value of the dielectric constant of the metal, owing to the non-perfectness of metals at optical frequencies.

  19. Effects of Climate and Climate Change on Vectors and Vector-Borne Diseases: Ticks Are Different.

    Science.gov (United States)

    Ogden, Nick H; Lindsay, L Robbin

    2016-08-01

    There has been considerable debate as to whether global risk from vector-borne diseases will be impacted by climate change. This has focussed on important mosquito-borne diseases that are transmitted by the vectors from infected to uninfected humans. However, this debate has mostly ignored the biological diversity of vectors and vector-borne diseases. Here, we review how climate and climate change may impact those most divergent of arthropod disease vector groups: multivoltine insects and hard-bodied (ixodid) ticks. We contrast features of the life cycles and behaviour of these arthropods, and how weather, climate, and climate change may have very different impacts on the spatiotemporal occurrence and abundance of vectors, and the pathogens they transmit.

  20. Effects of Climate and Climate Change on Vectors and Vector-Borne Diseases: Ticks Are Different.

    Science.gov (United States)

    Ogden, Nick H; Lindsay, L Robbin

    2016-08-01

    There has been considerable debate as to whether global risk from vector-borne diseases will be impacted by climate change. This has focussed on important mosquito-borne diseases that are transmitted by the vectors from infected to uninfected humans. However, this debate has mostly ignored the biological diversity of vectors and vector-borne diseases. Here, we review how climate and climate change may impact those most divergent of arthropod disease vector groups: multivoltine insects and hard-bodied (ixodid) ticks. We contrast features of the life cycles and behaviour of these arthropods, and how weather, climate, and climate change may have very different impacts on the spatiotemporal occurrence and abundance of vectors, and the pathogens they transmit. PMID:27260548

  1. Light scattering of rectangular slot antennas: parallel magnetic vector vs perpendicular electric vector

    Science.gov (United States)

    Lee, Dukhyung; Kim, Dai-Sik

    2016-01-01

    We study light scattering off rectangular slot nano antennas on a metal film varying incident polarization and incident angle, to examine which field vector of light is more important: electric vector perpendicular to, versus magnetic vector parallel to the long axis of the rectangle. While vector Babinet’s principle would prefer magnetic field along the long axis for optimizing slot antenna function, convention and intuition most often refer to the electric field perpendicular to it. Here, we demonstrate experimentally that in accordance with vector Babinet’s principle, the incident magnetic vector parallel to the long axis is the dominant component, with the perpendicular incident electric field making a small contribution of the factor of 1/|ε|, the reciprocal of the absolute value of the dielectric constant of the metal, owing to the non-perfectness of metals at optical frequencies.

  2. Multiclass Reduced-Set Support Vector Machines

    Science.gov (United States)

    Tang, Benyang; Mazzoni, Dominic

    2006-01-01

    There are well-established methods for reducing the number of support vectors in a trained binary support vector machine, often with minimal impact on accuracy. We show how reduced-set methods can be applied to multiclass SVMs made up of several binary SVMs, with significantly better results than reducing each binary SVM independently. Our approach is based on Burges' approach that constructs each reduced-set vector as the pre-image of a vector in kernel space, but we extend this by recomputing the SVM weights and bias optimally using the original SVM objective function. This leads to greater accuracy for a binary reduced-set SVM, and also allows vectors to be 'shared' between multiple binary SVMs for greater multiclass accuracy with fewer reduced-set vectors. We also propose computing pre-images using differential evolution, which we have found to be more robust than gradient descent alone. We show experimental results on a variety of problems and find that this new approach is consistently better than previous multiclass reduced-set methods, sometimes with a dramatic difference.

  3. Lentiviral vector gene transfer to porcine airways.

    Science.gov (United States)

    Sinn, Patrick L; Cooney, Ashley L; Oakland, Mayumi; Dylla, Douglas E; Wallen, Tanner J; Pezzulo, Alejandro A; Chang, Eugene H; McCray, Paul B

    2012-01-01

    In this study, we investigated lentiviral vector development and transduction efficiencies in well-differentiated primary cultures of pig airway epithelia (PAE) and wild-type pigs in vivo. We noted gene transfer efficiencies similar to that observed for human airway epithelia (HAE). Interestingly, feline immunodeficiency virus (FIV)-based vectors transduced immortalized pig cells as well as pig primary cells more efficiently than HIV-1-based vectors. PAE express TRIM5α, a well-characterized species-specific lentiviral restriction factor. We contrasted the restrictive properties of porcine TRIM5α against FIV- and HIV-based vectors using gain and loss of function approaches. We observed no effect on HIV-1 or FIV conferred transgene expression in response to porcine TRIM5α overexpression or knockdown. To evaluate the ability of GP64-FIV to transduce porcine airways in vivo, we delivered vector expressing mCherry to the tracheal lobe of the lung and the ethmoid sinus of 4-week-old pigs. One week later, epithelial cells expressing mCherry were readily detected. Our findings indicate that pseudotyped FIV vectors confer similar tropisms in porcine epithelia as observed in human HAE and provide further support for the selection of GP64 as an appropriate envelope pseudotype for future preclinical gene therapy studies in the porcine model of cystic fibrosis (CF).Molecular Therapy - Nucleic Acids (2012) 1, e56; doi:10.1038/mtna.2012.47; published online 27 November 2012. PMID:23187455

  4. An Algorithm for Interpolating Ship Motion Vectors

    Directory of Open Access Journals (Sweden)

    Qinyou Hu

    2014-03-01

    Full Text Available Interpolation of ship motion vectors is able to be used for estimating the lost ship AIS dynamic information, which is important for replaying marine accidents and for analysing marine traffic data. The previous methods can only interpolate ship's position, while not including ship's course and speed. In this paper, vector function is used to express the relationship between the ship's time and space coordinates, and the tangent of the vector function and its change rate are able to express physical characteristics of ship's course, speed and acceleration. The given AIS dynamic information can be applied to calculate the parameters of ship's vector function and then the interpolation model for ship motion vectors is developed to estimate the lost ship dynamic information at any given moment. Experiment results show that the ship motion vector function is able to depict the characteristics of ship motions accurately and the model can estimate not only the ship's position but also ship's course and speed at any given moment with limited differences.

  5. An Unbroken Axial Vector Current Conservation Law

    CERN Document Server

    Sharafiddinov, Rasulkhozha S

    2015-01-01

    The mass, energy and momentum of the neutrino of a true flavor have an axial-vector nature. As a consequence, the left-handed truly neutral neutrino in an axial-vector field of emission can be converted into a right-handed one and vice versa. This predicts the unidenticality of masses, energies and momenta of neutrinos of the different components. Recognizing such a difference in masses, energies, momenta and accepting that the left-handed axial-vector neutrino and the right-handed antineutrino of true neutrality refer to long-lived C-odd leptons, and the right-handed truly neutral neutrino and the left-handed axial-vector antineutrino are of short-lived fermions of C-oddity, we would write a new CP-even Dirac equation taking into account the flavor symmetrical axial-vector mass, energy and momentum matrices. Their presence explains the spontaneous mirror symmetry violation, confirming that an axial-vector current conservation law has never violated. They reflect the availability of a mirror Minkowski space i...

  6. Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors.

    Science.gov (United States)

    Trobridge, Grant; Russell, David W

    2004-03-01

    Retroviral vectors based on foamy viruses (FV) are efficient gene delivery vehicles for therapeutic and research applications. While previous studies have shown that FV vectors transduce quiescent cell cultures more efficiently than oncoviral vectors, their specific cell cycle requirements have not been determined. Here we compare the transduction frequencies of FV vectors with those of onco- and lentiviral vectors in nondividing and dividing normal human fibroblasts by several methods. FV vectors transduced serum-deprived fibroblast cultures more efficiently than oncoretroviral vectors and at rates comparable to those of lentiviral vectors. However, in these cultures FV vectors only transduced a subpopulation of proliferating cells, as determined by bromodeoxyuridine staining for DNA synthesis. In contrast to lentiviral vectors, FV vectors were unable to transduce human fibroblasts arrested by aphidicolin (G(1)/S phase) or gamma-irradiation (G(2) phase), and a partial cell cycle that included mitosis but not DNA synthesis was required. We could not determine if mitosis facilitated nuclear entry of FV vectors, since cell-free vector preparations contained long terminal repeat circles, precluding their use as nuclear markers. In contrast to oncoviral vectors, both FV and lentiviral vectors efficiently transduced G(0) fibroblasts that were later stimulated to divide. In the case of FV vectors, this was due to the persistence of a stable transduction intermediate in quiescent cells. Our findings support the use of FV vectors as a safe and effective alternative to lentiviral vectors for ex vivo transduction of stem cells that are quiescent during culture but divide following transplantation.

  7. Co-occurrence Vectors from Corpora vs. Distance Vectors from Dictionaries

    OpenAIRE

    Niwa, Yoshiki; Nitta, Yoshihiko

    1995-01-01

    A comparison was made of vectors derived by using ordinary co-occurrence statistics from large text corpora and of vectors derived by measuring the inter-word distances in dictionary definitions. The precision of word sense disambiguation by using co-occurrence vectors from the 1987 Wall Street Journal (20M total words) was higher than that by using distance vectors from the Collins English Dictionary (60K head words + 1.6M definition words). However, other experimental results suggest that d...

  8. A COMPREHENSIVE ANALYSIS OF SPACE VECTOR PWM TECHNIQUE BASED ON PLACEMENT OF ZERO-SPACE VECTOR

    Directory of Open Access Journals (Sweden)

    G.SAMBASIVA RAO,

    2011-04-01

    Full Text Available In this paper, the effect of placement of zero-space vector for the implementation of space vector based Pulse Width Modulation techniques for 3-phase Voltage Source Inverter is presented. Several pulse width modulation (PWM control strategies have been proposed for 3-phase voltage source inverter (VSI in the past. It is known that space vector modulation (SVM offers a degree of freedom in its implementation with regard to the placement of the zero-space vector. Apart from constructing a consistent theoretical framework, simulation results with conventional continuous SVM and various discontinuous SVM techniques are presented and all the cases are compared in this paper.

  9. Viral Vectors for in Vivo Gene Transfer

    Science.gov (United States)

    Thévenot, E.; Dufour, N.; Déglon, N.

    The transfer of DNA into the nucleus of a eukaryotic cell (gene transfer) is a central theme of modern biology. The transfer is said to be somatic when it refers to non-germline organs of a developed individual, and germline when it concerns gametes or the fertilised egg of an animal, with the aim of transmitting the relevant genetic modification to its descendents [1]. The efficient introduction of genetic material into a somatic or germline cell and the control of its expression over time have led to major advances in understanding how genes work in vivo, i.e., in living organisms (functional genomics), but also to the development of innovative therapeutic methods (gene therapy). The efficiency of gene transfer is conditioned by the vehicle used, called the vector. Desirable features for a vector are as follows: Easy to produce high titer stocks of the vector in a reproducible way. Absence of toxicity related to transduction (transfer of genetic material into the target cell, and its expression there) and no immune reaction of the organism against the vector and/or therapeutic protein. Stability in the expression of the relevant gene over time, and the possibility of regulation, e.g., to control expression of the therapeutic protein on the physiological level, or to end expression at the end of treatment. Transduction of quiescent cells should be as efficient as transduction of dividing cells. Vectors currently used fall into two categories: non-viral and viral vectors. In non-viral vectors, the DNA is complexed with polymers, lipids, or cationic detergents (described in Chap. 3). These vectors have a low risk of toxicity and immune reaction. However, they are less efficient in vivo than viral vectors when it comes to the number of cells transduced and long-term transgene expression. (Naked DNA transfer or electroporation is rather inefficient in the organism. This type of gene transfer will not be discussed here, and the interested reader is referred to the

  10. 40 CFR 503.33 - Vector attraction reduction.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Vector attraction reduction. 503.33... STANDARDS FOR THE USE OR DISPOSAL OF SEWAGE SLUDGE Pathogens and Vector Attraction Reduction § 503.33 Vector attraction reduction. (a)(1) One of the vector attraction reduction requirements in § 503.33 (b)(1)...

  11. Investigation of Optimal Integrated Circuit Raster Image Vectorization Method

    Directory of Open Access Journals (Sweden)

    Leonas Jasevičius

    2011-03-01

    Full Text Available Visual analysis of integrated circuit layer requires raster image vectorization stage to extract layer topology data to CAD tools. In this paper vectorization problems of raster IC layer images are presented. Various line extraction from raster images algorithms and their properties are discussed. Optimal raster image vectorization method was developed which allows utilization of common vectorization algorithms to achieve the best possible extracted vector data match with perfect manual vectorization results. To develop the optimal method, vectorized data quality dependence on initial raster image skeleton filter selection was assessed.Article in Lithuanian

  12. Perceptual vector quantization for video coding

    Science.gov (United States)

    Valin, Jean-Marc; Terriberry, Timothy B.

    2015-03-01

    This paper applies energy conservation principles to the Daala video codec using gain-shape vector quantization to encode a vector of AC coefficients as a length (gain) and direction (shape). The technique originates from the CELT mode of the Opus audio codec, where it is used to conserve the spectral envelope of an audio signal. Conserving energy in video has the potential to preserve textures rather than low-passing them. Explicitly quantizing a gain allows a simple contrast masking model with no signaling cost. Vector quantizing the shape keeps the number of degrees of freedom the same as scalar quantization, avoiding redundancy in the representation. We demonstrate how to predict the vector by transforming the space it is encoded in, rather than subtracting off the predictor, which would make energy conservation impossible. We also derive an encoding of the vector-quantized codewords that takes advantage of their non-uniform distribution. We show that the resulting technique outperforms scalar quantization by an average of 0.90 dB on still images, equivalent to a 24.8% reduction in bitrate at equal quality, while for videos, the improvement averages 0.83 dB, equivalent to a 13.7% reduction in bitrate.

  13. LHC Signatures of Vector-Like Quarks

    Directory of Open Access Journals (Sweden)

    Yasuhiro Okada

    2013-01-01

    Full Text Available This work provides an overview on the current status of phenomenology and searches for heavy vector-like quarks, which are predicted in many models of new physics beyond the Standard Model. Searches at Tevatron and at the LHC, here listed and shortly described, have not found any evidence for new heavy fermionic states (either chiral or vector-like and have therefore posed strong bounds on their masses: depending on specific assumptions on the interactions and on the observed final state, vector-like quarks with masses up to roughly 400–600 GeV have been excluded by all experiments. In order to be as simple and model independent as possible, the chosen framework for the phenomenological analysis is an effective model with the addition of a vector-like quark representation (singlet, doublet, or triplet under SU(2L which couples through Yukawa interactions with all SM families. The relevance of different observables for the determination of bounds on mixing parameters is then discussed and a complete overview of possible two body final states for every vector-like quark is provided, including their subsequent decay into SM particles. A list and short description of phenomenological analyses present in the literature are also provided for reference purposes.

  14. Application of Vector Triggering Random Decrement

    DEFF Research Database (Denmark)

    Asmussen, J. C.; Ibrahim, S. R.; Brincker, Rune

    1997-01-01

    This paper deals with applications of the vector triggering Random Decrement technique. This technique is new and developed with the aim of minimizing estimation time and identification errors. The theory behind the technique is discussed in an accompanying paper. The results presented in this pa......This paper deals with applications of the vector triggering Random Decrement technique. This technique is new and developed with the aim of minimizing estimation time and identification errors. The theory behind the technique is discussed in an accompanying paper. The results presented...... result is a Random Decrement function from each measurement. In traditional Random Decrement estimation the triggering condition is a scalar condition, which should only be fulfilled in a single measurement. In vector triggering Random Decrement the triggering condition is a vector condition....... The advantage of this new approach should be a reduction in estimation time without a significant loss of accuracy, since the vector triggering conditions ensure cross information between the measurements in the Random Decrement functions. The different problems with this technique is highlighted in two...

  15. Application of Vector Triggering Random Decrement

    DEFF Research Database (Denmark)

    Asmussen, J. C.; Ibrahim, S. R.; Brincker, Rune

    This paper deals with applications of the vector triggering Random Decrement technique. This technique is new and developed with the aim of minimizing estimation time and identification errors. The theory behind the technique is discussed in an accompanying paper. The results presented in this pa......This paper deals with applications of the vector triggering Random Decrement technique. This technique is new and developed with the aim of minimizing estimation time and identification errors. The theory behind the technique is discussed in an accompanying paper. The results presented...... result is a Random Decrement function from each measurement. In traditional Random Decrement estimation the triggering condition is a scalar condition, which should only be fulfilled in a single measurement. In vector triggering Random Decrement the triggering condition is a vector condition....... The advantage of this new approach should be a reduction in estimation time without a significant loss of accuracy, since the vector triggering conditions ensure cross information between the measurements in the Random Decrement functions. The different problems with this technique is highlighted in two...

  16. Intersectoral approaches to dengue vector control.

    Science.gov (United States)

    Kay, B H

    1994-12-01

    Medical entomology in the context of urban vector control, especially for dengue, can be likened to the tail of a dog. Vertically structured Aedes aegypti campaigns such as run by Gorgas and Soper earlier this century relied on sufficient legislative backing for vector control to ensure that the tail was capable of wagging the dog. Under these conditions, especially where individual rights do not intrude, vertical programs will be successful. The global expansion of dengue, dengue hemorrhagic fever and its vectors, plus growing trends towards urban/periurban living indicate a more serious scenario than at present. In 1987, the Brundtland Report: "Our Common Future" decried sectoralism in problem solving. Following the United Nations Conference on Environment and Development (UNCED) in 1992, the resulting Commission on Sustainable Development has promoted the intersectoral message of health, environment and development. The WHO/FAO/UNEP/UNCHS Panel of Experts on Environmental Management for Vector Control has promoted this for some time and is attempting to build multidisciplinary projects against urban vector borne disease. Adequate solid waste management and recycling will reduce numbers of water bearing containers infested with Aedes aegypti and provision of reliable piped water supplies will impact heavily on infested water storage containers. Both should be encouraged as viable control options. For much of the world, vertical programs have been reported as prohibitively expensive, and unacceptable intrusion on human rights and thus unsustainable in the modern economic context. However there are successful modern examples.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7844851

  17. Vector processing of the neutron transport codes

    International Nuclear Information System (INIS)

    One of the large computations in JAERI is the neutron transport ones used for reactor shielding and criticality analyses. The adaptability of vector processings has been investigated on the neutron transport codes under the assumption of future use of super-computer. Five codes have been tested. They are DOT3.5, TWOTRAN and ANISN based on finite difference method, and PALLAS-2DCY and BERMUDA on the direct integration method. It has been found that the gain from vectorization depends upon the numerical methods, geometries, and problems types to be solved. That is, the direct integration is rather suited for vector processing. But in the conventional finite difference method, the difference equation has an unvectorizable recurrence form in (r, z) and (r, -)-geometries. But by altering the interative process, the equation can be vectorized and some gains have been found to be achieved in a criticality problem. For each code, described are some views on vectorization, program restructurings, speedup ratio on F75 APU, numerical studies on the interative process, and so forth. (author)

  18. Improved Coinfection with Amphotropic Pseudotyped Retroviral Vectors

    Directory of Open Access Journals (Sweden)

    Yuehong Wu

    2009-01-01

    Full Text Available Amphotropic pseudotyped retroviral vectors have typically been used to infect target cells without prior concentration. Although this can yield high rates of infection, higher rates may be needed where highly efficient coinfection of two or more vectors is needed. In this investigation we used amphotropic retroviral vectors produced by the Plat-A cell line and studied coinfection rates using green and red fluorescent proteins (EGFP and dsRed2. Target cells were primary human fibroblasts (PHF and 3T3 cells. Unconcentrated vector preparations produced a coinfection rate of ∼4% (defined as cells that are both red and green as a percentage of all cells infected. Optimized spinoculation, comprising centrifugation at 1200 g for 2 hours at 15∘C, increased the coinfection rate to ∼10%. Concentration by centrifugation at 10,000 g or by flocculation using Polybrene increased the coinfection rate to ∼25%. Combining the two processes, concentration by Polybrene flocculation and optimized spinoculation, increased the coinfection rate to 35% (3T3 or >50% (PHF. Improved coinfection should be valuable in protocols that require high transduction by combinations of two or more retroviral vectors.

  19. Stability of Horndeski vector-tensor interactions

    Energy Technology Data Exchange (ETDEWEB)

    Jiménez, Jose Beltrán [Centre for Cosmology, Particle Physics and Phenomenology, Institute of Mathematics and Physics, Louvain University, 2 Chemin du Cyclotron, Louvain-la-Neuve, 1348 (Belgium); Durrer, Ruth; Heisenberg, Lavinia [Département de Physique Théorique and Center for Astroparticle Physics, Université de Genève, 24 quai Ansermet, Genève 4, CH-1211 (Switzerland); Thorsrud, Mikjel, E-mail: jose.beltran@uclouvain.be, E-mail: ruth.durrer@unige.ch, E-mail: lavinia.heisenberg@unige.ch, E-mail: mikjel.thorsrud@astro.uio.no [Institute of Theoretical Astrophysics, University of Oslo, P.O. Box 1029 Blindern, Oslo, N-0315 (Norway)

    2013-10-01

    We study the Horndeski vector-tensor theory that leads to second order equations of motion and contains a non-minimally coupled abelian gauge vector field. This theory is remarkably simple and consists of only 2 terms for the vector field, namely: the standard Maxwell kinetic term and a coupling to the dual Riemann tensor. Furthermore, the vector sector respects the U(1) gauge symmetry and the theory contains only one free parameter, M{sup 2}, that controls the strength of the non-minimal coupling. We explore the theory in a de Sitter spacetime and study the presence of instabilities and show that it corresponds to an attractor solution in the presence of the vector field. We also investigate the cosmological evolution and stability of perturbations in a general FLRW spacetime. We find that a sufficient condition for the absence of ghosts is M{sup 2} > 0. Moreover, we study further constraints coming from imposing the absence of Laplacian instabilities. Finally, we study the stability of the theory in static and spherically symmetric backgrounds (in particular, Schwarzschild and Reissner-Nordström-de Sitter). We find that the theory, quite generally, do have ghosts or Laplacian instabilities in regions of spacetime where the non-minimal interaction dominates over the Maxwell term. We also calculate the propagation speed in these spacetimes and show that superluminality is a quite generic phenomenon in this theory.

  20. Affine conformal vectors in space-time

    Science.gov (United States)

    Coley, A. A.; Tupper, B. O. J.

    1992-05-01

    All space-times admitting a proper affine conformal vector (ACV) are found. By using a theorem of Hall and da Costa, it is shown that such space-times either (i) admit a covariantly constant vector (timelike, spacelike, or null) and the ACV is the sum of a proper affine vector and a conformal Killing vector or (ii) the space-time is 2+2 decomposable, in which case it is shown that no ACV can exist (unless the space-time decomposes further). Furthermore, it is proved that all space-times admitting an ACV and a null covariantly constant vector (which are necessarily generalized pp-wave space-times) must have Ricci tensor of Segré type {2,(1,1)}. It follows that, among space-times admitting proper ACV, the Einstein static universe is the only perfect fluid space-time, there are no non-null Einstein-Maxwell space-times, and only the pp-wave space-times are representative of null Einstein-Maxwell solutions. Otherwise, the space-times can represent anisotropic fluids and viscous heat-conducting fluids, but only with restricted equations of state in each case.

  1. Support vector machine applied in QSAR modelling

    Institute of Scientific and Technical Information of China (English)

    MEI Hu; ZHOU Yuan; LIANG Guizhao; LI Zhiliang

    2005-01-01

    Support vector machine (SVM), partial least squares (PLS), and Back-Propagation artificial neural network (ANN) were employed to establish QSAR models of 2 dipeptide datasets. In order to validate predictive capabilities on external dataset of the resulting models, both internal and external validations were performed. The division of dataset into both training and test sets was carried out by D-optimal design. The results showed that support vector machine (SVM) behaved well in both calibration and prediction. For the dataset of 48 bitter tasting dipeptides (BTD), the results obtained by support vector regression (SVR) were superior to that by PLS in both calibration and prediction. When compared with BP artificial neural network, SVR showed less calibration power but more predictive capability. For the dataset of angiotensin-converting enzyme (ACE) inhibitors, the results obtained by support vector machine (SVM) regression were equivalent to those by PLS and BP artificial neural network. In both datasets, SVR using linear kernel function behaved well as that using radial basis kernel function. The results showed that there is wide prospect for the application of support vector machine (SVM) into QSAR modeling.

  2. Test of Understanding of Vectors: A Reliable Multiple-Choice Vector Concept Test

    Science.gov (United States)

    Barniol, Pablo; Zavala, Genaro

    2014-01-01

    In this article we discuss the findings of our research on students' understanding of vector concepts in problems without physical context. First, we develop a complete taxonomy of the most frequent errors made by university students when learning vector concepts. This study is based on the results of several test administrations of…

  3. Auto-tuning Dense Vector and Matrix-vector Operations for Fermi GPUs

    DEFF Research Database (Denmark)

    Sørensen, Hans Henrik Brandenborg

    2012-01-01

    In this paper, we consider the automatic performance tuning of dense vector and matrix-vector operations on GPUs. Such operations form the backbone of level 1 and level 2 routines in the Basic Linear Algebra Subroutines (BLAS) library and are therefore of great importance in many scientific...

  4. Reduced Order Model Basis Vector Generation: Generates Basis Vectors fro ROMs

    Energy Technology Data Exchange (ETDEWEB)

    2016-03-03

    libROM is a library that implements order reduction via singular value decomposition (SVD) of sampled state vectors. It implements 2 parallel, incremental SVD algorithms and one serial, non-incremental algorithm. It also provides a mechanism for adaptive sampling of basis vectors.

  5. Vectorization, parallelization and porting of nuclear codes. Vectorization and parallelization. Progress report fiscal 1999

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Masaaki; Ogasawara, Shinobu; Kume, Etsuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Ishizuki, Shigeru; Nemoto, Toshiyuki; Kawasaki, Nobuo; Kawai, Wataru [Fujitsu Ltd., Tokyo (Japan); Yatake, Yo-ichi [Hitachi Ltd., Tokyo (Japan)

    2001-02-01

    Several computer codes in the nuclear field have been vectorized, parallelized and trans-ported on the FUJITSU VPP500 system, the AP3000 system, the SX-4 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 18 codes in fiscal 1999. These results are reported in 3 parts, i.e., the vectorization and the parallelization part on vector processors, the parallelization part on scalar processors and the porting part. In this report, we describe the vectorization and parallelization on vector processors. In this vectorization and parallelization on vector processors part, the vectorization of Relativistic Molecular Orbital Calculation code RSCAT, a microscopic transport code for high energy nuclear collisions code JAM, three-dimensional non-steady thermal-fluid analysis code STREAM, Relativistic Density Functional Theory code RDFT and High Speed Three-Dimensional Nodal Diffusion code MOSRA-Light on the VPP500 system and the SX-4 system are described. (author)

  6. Support vector machines/relevance vector machine for remote sensing classification: A review

    CERN Document Server

    Pal, Mahesh

    2011-01-01

    Kernel-based machine learning algorithms are based on mapping data from the original input feature space to a kernel feature space of higher dimensionality to solve a linear problem in that space. Over the last decade, kernel based classification and regression approaches such as support vector machines have widely been used in remote sensing as well as in various civil engineering applications. In spite of their better performance with different datasets, support vector machines still suffer from shortcomings such as visualization/interpretation of model, choice of kernel and kernel specific parameter as well as the regularization parameter. Relevance vector machines are another kernel based approach being explored for classification and regression with in last few years. The advantages of the relevance vector machines over the support vector machines is the availability of probabilistic predictions, using arbitrary kernel functions and not requiring setting of the regularization parameter. This paper presen...

  7. GENERALIZED VECTOR VARIATIONAL-TYPE INEQUALITIES IN FC-SPACES

    Institute of Scientific and Technical Information of China (English)

    FANG Min; DING Xie-ping

    2006-01-01

    A class of generalized vector variational-type inequality problems (GVVTIP) are studied in FC-spaces, which includes the most of vector equilibrium problems, vector variational inequality problems, generalized vector equilibrium problems and generalized vector variational inequality problem as special cases. By using F-KKM theorem,some new existence results for GVVTIP are established in noncompact FC-space. As consequences, some recent known results in literature are obtained under much weaker assumption.

  8. QCD sum rule analysis for light vector and axial-vector mesons in vacuum and nuclear matter

    OpenAIRE

    Leupold, Stefan

    2001-01-01

    Extending previous work we study the constraints of QCD sum rules on mass and width of light vector and axial-vector mesons in vacuum and in a medium with finite nuclear density. For the latter case especially the effect of nuclear pions leading to vector-axial-vector mixing is included in the analysis.

  9. Emergence and prevalence of human vector-borne diseases in sink vector populations.

    Directory of Open Access Journals (Sweden)

    Guilhem Rascalou

    Full Text Available Vector-borne diseases represent a major public health concern in most tropical and subtropical areas, and an emerging threat for more developed countries. Our understanding of the ecology, evolution and control of these diseases relies predominantly on theory and data on pathogen transmission in large self-sustaining 'source' populations of vectors representative of highly endemic areas. However, there are numerous places where environmental conditions are less favourable to vector populations, but where immigration allows them to persist. We built an epidemiological model to investigate the dynamics of six major human vector borne-diseases in such non self-sustaining 'sink' vector populations. The model was parameterized through a review of the literature, and we performed extensive sensitivity analysis to look at the emergence and prevalence of the pathogen that could be encountered in these populations. Despite the low vector abundance in typical sink populations, all six human diseases were able to spread in 15-55% of cases after accidental introduction. The rate of spread was much more strongly influenced by vector longevity, immigration and feeding rates, than by transmission and virulence of the pathogen. Prevalence in humans remained lower than 5% for dengue, leishmaniasis and Japanese encephalitis, but substantially higher for diseases with longer duration of infection; malaria and the American and African trypanosomiasis. Vector-related parameters were again the key factors, although their influence was lower than on pathogen emergence. Our results emphasize the need for ecology and evolution to be thought in the context of metapopulations made of a mosaic of sink and source habitats, and to design vector control program not only targeting areas of high vector density, but working at a larger spatial scale.

  10. Genetic Modification of Baculovirus Expression Vectors

    Institute of Scientific and Technical Information of China (English)

    Shu-fen Li; Hua-lin Wang; Zhi-hong Hu; Fei Deng

    2012-01-01

    As a protein expression vector,the baculovirus demonstrates many advantages over other vectors.With the development of biotechnology,baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells.These modifications include utilization of different promoters and signal peptides,deletion or replacement of viral genes for increasing protein secretion,integration of polycistronic expression cassette for producing protein complexes,and baculovirus pseudotyping,promoter accommodation or surface display for enhancing mammalian cell targeting gene delivery.This review summarizes the development and the current state of art of the baculovirus expression system.Further development of baculovirus expression systems will make them even more feasible and accessible for advanced applications.

  11. Improving DNA vaccine performance through vector design.

    Science.gov (United States)

    Williams, James A

    2014-01-01

    DNA vaccines are a rapidly deployed next generation vaccination platform for treatment of human and animal disease. DNA delivery devices, such as electroporation and needle free jet injectors, are used to increase gene transfer. This results in higher antigen expression which correlates with improved humoral and cellular immunity in humans and animals. This review highlights recent vector and transgene design innovations that improve DNA vaccine performance. These new vectors improve antigen expression, increase plasmid manufacturing yield and quality in bioreactors, and eliminate antibiotic selection and other potential safety issues. A flowchart for designing synthetic antigen transgenes, combining antigen targeting, codon-optimization and bioinformatics, is presented. Application of improved vectors, of antibiotic free plasmid production, and cost effective manufacturing technologies will be critical to ensure safety, efficacy, and economically viable manufacturing of DNA vaccines currently under development for infectious disease, cancer, autoimmunity, immunotolerance and allergy indications.

  12. Molecular Epidemiology for Vector Research on Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Hirotomo Kato

    2010-03-01

    Full Text Available Leishmaniasis is a protozoan disease caused by the genus Leishmania transmitted by female phlebotomine sand flies. Surveillance of the prevalence of Leishmania and responsive vector species in endemic and surrounding areas is important for predicting the risk and expansion of the disease. Molecular biological methods are now widely applied to epidemiological studies of infectious diseases including leishmaniasis. These techniques are used to detect natural infections of sand fly vectors with Leishmania protozoa and are becoming powerful tools due to their sensitivity and specificity. Recently, genetic analyses have been performed on sand fly species and genotyping using PCR-RFLP has been applied to the sand fly taxonomy. In addition, a molecular mass screening method has been established that enables both sand fly species and natural leishmanial infections to be identified simultaneously in hundreds of sand flies with limited effort. This paper reviews recent advances in the study of sand flies, vectors of leishmaniasis, using molecular biological approaches.

  13. Resonance vector soliton of the Rayleigh wave.

    Science.gov (United States)

    Adamashvili, G T

    2016-02-01

    A theory of acoustic vector solitons of self-induced transparency of the Rayleigh wave is constructed. A thin resonance transition layer on an elastic surface is considered using a model of a two-dimensional gas of impurity paramagnetic atoms or quantum dots. Explicit analytical expressions for the profile and parameters of the Rayleigh vector soliton with two different oscillation frequencies is obtained, as well as simulations of this nonlinear surface acoustic wave with realistic parameters, which can be used in acoustic experiments. It is shown that the properties of a surface vector soliton of the Rayleigh wave depend on the parameters of the resonance layer, the elastic medium, and the transverse structure of the surface acoustic wave. PMID:26986400

  14. Vector processor algorithms for transonic flow calculations

    Science.gov (United States)

    South, J. C., Jr.; Keller, J. D.; Hafez, M. M.

    1979-01-01

    This paper discusses a number of algorithms for solving the transonic full-potential equation in conservative form on a vector computer, such as the CDC STAR-100 or the CRAY-1. Recent research with the 'artificial density' method for transonics has led to development of some new iteration schemes which take advantage of vector-computer architecture without suffering significant loss of convergence rate. Several of these more promising schemes are described and 2-D and 3-D results are shown comparing the computational rates on the STAR and CRAY vector computers, and the CYBER-175 serial computer. Schemes included are: (1) Checkerboard SOR, (2) Checkerboard Leapfrog, (3) odd-even vertical line SOR, and (4) odd-even horizontal line SOR.

  15. Diffractive vector meson leptoproduction and spin effects

    CERN Document Server

    Goloskokov, S V

    2006-01-01

    We analyse spin effects in diffractive vector meson leptoproduction at small $x$ on the basis of the generalized parton distribution (GPD) approach. We take into account quark transverse degrees of freedom in the hard subprocess. We calculate amplitudes for the longitudinally and transversely polarized photons and vector mesons. Our results on the cross section and spin density matrix elements (SDME) are in fair agreement with the DESY experiments. Predictions for HERMES and COMPASS energy range are made. The predicted double spin longitudinal $A_{LL}$ asymmetry is not small at HERMES energies

  16. Vector Fields and Flows on Differentiable Stacks

    DEFF Research Database (Denmark)

    A. Hepworth, Richard

    2009-01-01

    and uniqueness of flows on a manifold as well as the author's existing results for orbifolds. It sets the scene for a discussion of Morse Theory on a general proper stack and also paves the way for the categorification of other key aspects of differential geometry such as the tangent bundle and the Lie algebra......This paper introduces the notions of vector field and flow on a general differentiable stack. Our main theorem states that the flow of a vector field on a compact proper differentiable stack exists and is unique up to a uniquely determined 2-cell. This extends the usual result on the existence...

  17. Classifying LEP Data with Support Vector Algorithms

    CERN Document Server

    Vannerem, P; Schölkopf, B; Smola, A J; Söldner-Rembold, S

    1999-01-01

    We have studied the application of different classification algorithms in the analysis of simulated high energy physics data. Whereas Neural Network algorithms have become a standard tool for data analysis, the performance of other classifiers such as Support Vector Machines has not yet been tested in this environment. We chose two different problems to compare the performance of a Support Vector Machine and a Neural Net trained with back-propagation: tagging events of the type e+e- -> ccbar and the identification of muons produced in multihadronic e+e- annihilation events.

  18. Oracle Inequalities for High Dimensional Vector Autoregressions

    DEFF Research Database (Denmark)

    Callot, Laurent; Kock, Anders Bredahl

    This paper establishes non-asymptotic oracle inequalities for the prediction error and estimation accuracy of the LASSO in stationary vector autoregressive models. These inequalities are used to establish consistency of the LASSO even when the number of parameters is of a much larger order...... hence the correct sparsity pattern). Finally conditions under which the Adaptive LASSO reveals the correct sign pattern with probability tending to one are given. Again, the number of parameters may be much larger than the sample size. Some maximal inequalities for vector autoregressions which might...

  19. Support Vector classifiers for Land Cover Classification

    CERN Document Server

    Pal, Mahesh

    2008-01-01

    Support vector machines represent a promising development in machine learning research that is not widely used within the remote sensing community. This paper reports the results of Multispectral(Landsat-7 ETM+) and Hyperspectral DAIS)data in which multi-class SVMs are compared with maximum likelihood and artificial neural network methods in terms of classification accuracy. Our results show that the SVM achieves a higher level of classification accuracy than either the maximum likelihood or the neural classifier, and that the support vector machine can be used with small training datasets and high-dimensional data.

  20. The vector-like twin Higgs

    Science.gov (United States)

    Craig, Nathaniel; Knapen, Simon; Longhi, Pietro; Strassler, Matthew

    2016-07-01

    We present a version of the twin Higgs mechanism with vector-like top partners. In this setup all gauge anomalies automatically cancel, even without twin leptons. The matter content of the most minimal twin sector is therefore just two twin tops and one twin bottom. The LHC phenomenology, illustrated with two example models, is dominated by twin glueball decays, possibly in association with Higgs bosons. We further construct an explicit four-dimensional UV completion and discuss a variety of UV completions relevant for both vector-like and fraternal twin Higgs models.

  1. The Vector-like Twin Higgs

    CERN Document Server

    Craig, Nathaniel; Longhi, Pietro; Strassler, Matthew

    2016-01-01

    We present a version of the twin Higgs mechanism with vector-like top partners. In this setup all gauge anomalies automatically cancel, even without twin leptons. The matter content of the most minimal twin sector is therefore just two twin tops and one twin bottom. The LHC phenomenology, illustrated with two example models, is dominated by twin glueball decays, possibly in association with Higgs bosons. We further construct an explicit four-dimensional UV completion and discuss a variety of UV completions relevant for both vector-like and fraternal twin Higgs models.

  2. Lepton flavor violation with light vector bosons

    Science.gov (United States)

    Heeck, Julian

    2016-07-01

    New sub-GeV vector bosons with couplings to muons but not electrons have been discussed in order to explain the muon's magnetic moment, the gap of high-energy neutrinos in IceCube or the proton radius puzzle. If such a light Z‧ not only violates lepton universality but also lepton flavor, as expected for example from the recent hint for h → μτ at CMS, the two-body decay mode τ → μZ‧ opens up and for MZ‧ year-old ARGUS limits. We discuss the general prospects and motivation of light vector bosons with lepton-flavor-violating couplings.

  3. Retrotransposon vectors for gene delivery in plants

    Directory of Open Access Journals (Sweden)

    Hou Yi

    2010-08-01

    Full Text Available Abstract Background Retrotransposons are abundant components of plant genomes, and although some plant retrotransposons have been used as insertional mutagens, these mobile genetic elements have not been widely exploited for plant genome manipulation. In vertebrates and yeast, retrotransposons and retroviruses are routinely altered to carry additional genes that are copied into complementary (cDNA through reverse transcription. Integration of cDNA results in gene delivery; recombination of cDNA with homologous chromosomal sequences can create targeted gene modifications. Plant retrotransposon-based vectors, therefore, may provide new opportunities for plant genome engineering. Results A retrotransposon vector system was developed for gene delivery in plants based on the Tnt1 element from Nicotiana tabacum. Mini-Tnt1 transfer vectors were constructed that lack coding sequences yet retain the 5' and 3' long terminal repeats (LTRs and adjacent cis sequences required for reverse transcription. The internal coding region of Tnt1 was replaced with a neomycin phosphotransferase gene to monitor replication by reverse transcription. Two different mini-Tnt1 s were developed: one with the native 5' LTR and the other with a chimeric 5' LTR that had the first 233 bp replaced by the CaMV 35 S promoter. After transfer into tobacco protoplasts, both vectors undergo retrotransposition using GAG and POL proteins provided in trans by endogenous Tnt1 elements. The transposition frequencies of mini-Tnt1 vectors are comparable with native Tnt1 elements, and like the native elements, insertion sites are within or near coding sequences. In this paper, we provide evidence that template switching occurs during mini-Tnt1 reverse transcription, indicating that multiple copies of Tnt1 mRNA are packaged into virus-like particles. Conclusions Our data demonstrate that mini-Tnt1 vectors can replicate efficiently in tobacco cells using GAG and POL proteins provided in trans by

  4. Gammaretroviral Vectors: Biology, Technology and Application

    Directory of Open Access Journals (Sweden)

    Axel Schambach

    2011-06-01

    Full Text Available Retroviruses are evolutionary optimized gene carriers that have naturally adapted to their hosts to efficiently deliver their nucleic acids into the target cell chromatin, thereby overcoming natural cellular barriers. Here we will review—starting with a deeper look into retroviral biology—how Murine Leukemia Virus (MLV, a simple gammaretrovirus, can be converted into an efficient vehicle of genetic therapeutics. Furthermore, we will describe how more rational vector backbones can be designed and how these so-called self-inactivating vectors can be pseudotyped and produced. Finally, we will provide an overview on existing clinical trials and how biosafety can be improved.

  5. Vector Fields European user group meeting

    CERN Multimedia

    2007-01-01

    The "Vector Fields European user group meeting" will take place at CERN on 26 and 27 September 2007. Within this framework two workshops are organized at the CERN Training Centre: 24 September 2007
 Modelling Magnets with Opera 25 September 2007
Modelling of Charged Particle Beam Devices with Opera If you are interested in attending the workshop or the user group meeting please contact Julie Shepherd (Vector Fields) or Pierre Baehler (CERN) directly at: Julie.Shepherd@vectorfields.co.uk, +44 (0) 1865 854933 or +44 (0) 1865 370151 Pierre.Baehler@cern.ch, 75016 / 160156.

  6. Polynomial Vector Fields in One Complex Variable

    DEFF Research Database (Denmark)

    Branner, Bodil

    In recent years Adrien Douady was interested in polynomial vector fields, both in relation to iteration theory and as a topic on their own. This talk is based on his work with Pierrette Sentenac, work of Xavier Buff and Tan Lei, and my own joint work with Kealey Dias.......In recent years Adrien Douady was interested in polynomial vector fields, both in relation to iteration theory and as a topic on their own. This talk is based on his work with Pierrette Sentenac, work of Xavier Buff and Tan Lei, and my own joint work with Kealey Dias....

  7. Nonlinear dynamics of a vectored thrust aircraft

    DEFF Research Database (Denmark)

    Sørensen, C.B; Mosekilde, Erik

    1996-01-01

    With realistic relations for the aerodynamic coefficients, numerical simulations are applied to study the longitudional dynamics of a thrust vectored aircraft. As function of the thrust magnitude and the thrust vectoring angle the equilibrium state exhibits two saddle-node bifurcations and three...... Hopf bifurcations. Even when the equilibrium state is stable, weakly damped oscillations occur with a period of 1 min. If, in an attempt to compensate for these oscillations, the thrust deflection is periodically adjusted, a complicated structure of overlapping torus, saddle-node and period......-doubling bifurcations arises. This structure is investigated by combining brute force bifurcation diagrams with one- and two-dimensional continuation analyses....

  8. Stability Analysis of Path-vector Routing

    CERN Document Server

    Dimitri, Papadimitriou

    2012-01-01

    Most studies on path-vector routing stability have been conducted empirically by means of ad-hoc analysis of BGP data traces. None of them consider prior specification of an analytic method including the use of stability measurement metrics for the systematic analysis of BGP traces and associated meta-processing for determining the local state of the routing system. In this paper, we define a set of metrics that characterize the local stability properties of path-vector routing such as BGP (Border Gateway Protocol). By means of these stability metrics, we propose a method to analyze the effects of BGP policy- and protocol-induced instability on local routers.

  9. New vector bosons and the diphoton excess

    OpenAIRE

    Jorge de Blas; José Santiago; Roberto Vega-Morales(Laboratoire de Physique Théorique d’Orsay, UMR8627-CNRS, Université Paris-Sud 11, F-91405 Orsay Cedex, France)

    2016-01-01

    We consider the possibility that the recently observed diphoton excess at ∼750 GeV can be explained by the decay of a scalar particle (φ) to photons. If the scalar is the remnant of a symmetry-breaking sector of some new gauge symmetry, its coupling to photons can be generated by loops of the charged massive vectors of the broken symmetry. If these new W′ vector bosons carry color, they can also generate an effective coupling to gluons. In this case the diphoton excess could be entirely expla...

  10. Singular vectors in logarithmic conformal field theories

    International Nuclear Information System (INIS)

    Null vectors are generalized to the case of indecomposable representations which are one of the main features of logarithmic conformal field theories. This is done by developing a compact formalism with the particular advantage that the stress energy tensor acting on Jordan cells of primary fields and their logarithmic partners can still be represented in form of linear differential operators. Since the existence of singular vectors is subject to much stronger constraints than in regular conformal field theory, they also provide a powerful tool for the classification of logarithmic conformal field theories. (orig.)

  11. One-Dimensional Vector Based Pattern Matching

    Directory of Open Access Journals (Sweden)

    Y.M.Fouda

    2014-08-01

    Full Text Available Template matching is a basic method in image analysis to extract useful information from images. In this paper, we suggest a new method for pattern matching. Our method transform the template image from two dimensional image into one dimensional vector. Also all sub - windows (same size of template in the reference image will transform into one dimensional vectors. The three similarity measures SAD, SSD, and Euclidean are used to c ompute the likeness between template and all sub - windows in the reference image to find the best match. The experimental results show the superior performance of the proposed metho d over the conventional methods on various template of different sizes

  12. Integrated vector management for malaria control

    Directory of Open Access Journals (Sweden)

    Impoinvil Daniel E

    2008-12-01

    Full Text Available Abstract Integrated vector management (IVM is defined as "a rational decision-making process for the optimal use of resources for vector control" and includes five key elements: 1 evidence-based decision-making, 2 integrated approaches 3, collaboration within the health sector and with other sectors, 4 advocacy, social mobilization, and legislation, and 5 capacity-building. In 2004, the WHO adopted IVM globally for the control of all vector-borne diseases. Important recent progress has been made in developing and promoting IVM for national malaria control programmes in Africa at a time when successful malaria control programmes are scaling-up with insecticide-treated nets (ITN and/or indoor residual spraying (IRS coverage. While interventions using only ITNs and/or IRS successfully reduce transmission intensity and the burden of malaria in many situations, it is not clear if these interventions alone will achieve those critical low levels that result in malaria elimination. Despite the successful employment of comprehensive integrated malaria control programmes, further strengthening of vector control components through IVM is relevant, especially during the "end-game" where control is successful and further efforts are required to go from low transmission situations to sustained local and country-wide malaria elimination. To meet this need and to ensure sustainability of control efforts, malaria control programmes should strengthen their capacity to use data for decision-making with respect to evaluation of current vector control programmes, employment of additional vector control tools in conjunction with ITN/IRS tactics, case-detection and treatment strategies, and determine how much and what types of vector control and interdisciplinary input are required to achieve malaria elimination. Similarly, on a global scale, there is a need for continued research to identify and evaluate new tools for vector control that can be integrated with

  13. Variable ordering structures in vector optimization

    CERN Document Server

    Eichfelder, Gabriele

    2014-01-01

    This book provides an introduction to vector optimization with variable ordering structures, i.e., to optimization problems with a vector-valued objective function where the elements in the objective space are compared based on a variable ordering structure: instead of a partial ordering defined by a convex cone, we see a whole family of convex cones, one attached to each element of the objective space. The book starts by presenting several applications that have recently sparked new interest in these optimization problems, and goes on to discuss fundamentals and important results on a wide ra

  14. The Interaction between Vector Life History and Short Vector Life in Vector-Borne Disease Transmission and Control.

    Science.gov (United States)

    Brand, Samuel P C; Rock, Kat S; Keeling, Matt J

    2016-04-01

    Epidemiological modelling has a vital role to play in policy planning and prediction for the control of vectors, and hence the subsequent control of vector-borne diseases. To decide between competing policies requires models that can generate accurate predictions, which in turn requires accurate knowledge of vector natural histories. Here we highlight the importance of the distribution of times between life-history events, using short-lived midge species as an example. In particular we focus on the distribution of the extrinsic incubation period (EIP) which determines the time between infection and becoming infectious, and the distribution of the length of the gonotrophic cycle which determines the time between successful bites. We show how different assumptions for these periods can radically change the basic reproductive ratio (R0) of an infection and additionally the impact of vector control on the infection. These findings highlight the need for detailed entomological data, based on laboratory experiments and field data, to correctly construct the next-generation of policy-informing models. PMID:27128163

  15. The Cross Product of Two Vectors Is Not Just Another Vector--A Major Misconception Being Perpetuated in Calculus and Vector Analysis Textbooks.

    Science.gov (United States)

    Elk, Seymour B.

    1997-01-01

    Suggests that the cross product of two vectors can be more easily and accurately explained by starting from the perspective of dyadics because then the concept of vector multiplication has a simple geometrical picture that encompasses both the dot and cross products in any number of dimensions in terms of orthogonal unit vector components. (AIM)

  16. Integrating Transgenic Vector Manipulation with Clinical Interventions to Manage Vector-Borne Diseases.

    Directory of Open Access Journals (Sweden)

    Kenichi W Okamoto

    2016-03-01

    Full Text Available Many vector-borne diseases lack effective vaccines and medications, and the limitations of traditional vector control have inspired novel approaches based on using genetic engineering to manipulate vector populations and thereby reduce transmission. Yet both the short- and long-term epidemiological effects of these transgenic strategies are highly uncertain. If neither vaccines, medications, nor transgenic strategies can by themselves suffice for managing vector-borne diseases, integrating these approaches becomes key. Here we develop a framework to evaluate how clinical interventions (i.e., vaccination and medication can be integrated with transgenic vector manipulation strategies to prevent disease invasion and reduce disease incidence. We show that the ability of clinical interventions to accelerate disease suppression can depend on the nature of the transgenic manipulation deployed (e.g., whether vector population reduction or replacement is attempted. We find that making a specific, individual strategy highly effective may not be necessary for attaining public-health objectives, provided suitable combinations can be adopted. However, we show how combining only partially effective antimicrobial drugs or vaccination with transgenic vector manipulations that merely temporarily lower vector competence can amplify disease resurgence following transient suppression. Thus, transgenic vector manipulation that cannot be sustained can have adverse consequences-consequences which ineffective clinical interventions can at best only mitigate, and at worst temporarily exacerbate. This result, which arises from differences between the time scale on which the interventions affect disease dynamics and the time scale of host population dynamics, highlights the importance of accounting for the potential delay in the effects of deploying public health strategies on long-term disease incidence. We find that for systems at the disease-endemic equilibrium, even

  17. Vector Magnetic Fields and Electric Currents from the Imaging Vector Magnetograph

    OpenAIRE

    Li, Jing; van Ballegooijen, A. A.; Mickey, Don

    2008-01-01

    First, we describe a general procedure to produce high quality vector magnetograms using the Imaging Vector Magnetograph (IVM) at Mees Solar Observatory. At the spatial resolution 2"x2", the Stokes Q,U,V uncertainty reaches 0.001-0.0005 in time-averaged data over 1-hour in the quiet Sun. When vector magnetic fields are inferred from the time-averaged Stokes spectral images of FeI 6302.5A, the resulting uncertainties are on the order of 10 G for the longitudinal fields, 40 G for the transverse...

  18. Symmetries of Elko and massive vector fields

    CERN Document Server

    Lee, Cheng-Yang

    2013-01-01

    This thesis studies the symmetries and phenomenologies of the massive vector fields of indefinite spin with both scalar and spin-one degrees of freedom and Elko. The investigation is conducted by using and extending the quantum field theory formalism developed by Wigner and Weinberg. In particular, we explore the possibility that the $W^{\\pm}$ and $Z$ bosons have an additional scalar degree of freedom and show that Elko is a fermionic dark matter candidate. We show that the massive vector fields of indefinite spin are consistent with Poincar\\'{e} symmetry and have physically desirable properties that are absent for their pure spin-one counterpart. Using the new vector fields, the decay of the $W^{\\pm}$ and $Z$ bosons to leptons at tree-level are in agreement with the Standard Model (SM) predictions. For higher order scattering amplitudes, the theory has better convergent behaviour than the intermediate vector boson model and the Fermi theory. Elko has the unusual property that it satisfies the Klein-Gordon bu...

  19. Internal mode of incoherent photovoltaic vector solitons

    Institute of Scientific and Technical Information of China (English)

    Zhang Bing-Zhi; Wang Hong-Cheng; She Wei-Long

    2007-01-01

    The internal modes of incoherent vector solitons (IVSs) in photovoltaic photorefractive materials are investigated in the framework of coupled nonlinear Schr(o)dinger equations. It is found that there is a pair of internal modes corresponding to a bright-bright IVS. The propagation dynamics of the bright-bright IVS perturbed by the internal modes is simulated by numerical method.

  20. A versatile vector set for animal transgenesis.

    Science.gov (United States)

    Horn, C; Wimmer, E A

    2000-12-01

    Genetic manipulation of a series of diverged arthropods is a highly desirable goal for a better understanding of developmental and evolutionary processes. A major obstacle so far has been the difficulty in obtaining marker genes that allow easy and reliable identification of transgenic animals. Here, we present a versatile vector set for germline transformation based on the promiscuous transposons mariner, Hermes and piggyBac. Into these vectors, we introduced a potentially universal marker system that is comprised of an artificial promoter containing three Pax-6 homodimer binding sites. This promoter drives strong expression of spectral variants of the enhanced green fluorescent protein (EGFP) in larval, pupal, and adult photoreceptors. Using special filter sets, the yellow (EYFP) and cyan (ECFP) variant are fully distinguishable and therefore represent a separable pair of markers. Furthermore, we adapted a simple plasmid-based transposition assay system to enable quick functional tests of our vectors in different arthropod species before employing them in more laborious germline transformation experiments. Using this system we demonstrate that our vectors transpose in both Drosophila melanogaster and Drosophila virilis.

  1. Studies of Solar Vector Magnetic Field

    Institute of Scientific and Technical Information of China (English)

    WANG Jingxiu

    2011-01-01

    In this article, we report a few advances in the studies based on the solar vector magnetic field observations which were carried out mainly with the Solar Magnetic Field Telescope at the Huairou Solar Observing Station in the 1990s. (1) We developed necessary methodology and concepts in vector magnetogram analysis (Wang et al. 1996). For the first time, we proposed to use the photospheric free magnetic energy to quantify the major flare productivity of solar active regions (ARs), and it had been proved to be the best parameter in representing the major flare activity. (2) We revealed that there was always a dominant sense of magnetic shear in a given AR (Wang 1994), which was taken as the premise of the helicity calculation in ARs; we made the first quantitative estimation of magnetic helicity evolution in ARs (Wang 1996). (3) We identified the first group of evidence of magnetic reconnection in the lower solar atmosphere with vector magnetic field observations and proposed a two-step reconnection flare model to interpret the observed association of flux cancellation and flares (Wang and Shi 1993). Efforts to quantify the major flare productivity of super active regions with vector magnetic field observations have been also taken.

  2. Molluscicide control of snail vectors of schistosomiasis

    Directory of Open Access Journals (Sweden)

    Cecília Pereira de Souza

    1995-04-01

    Full Text Available A review of the methodology recommended by the World Health Organization for the use of molluscicides for the control of snail vectors of schistosomiasis is presented. Discussion of the principle molluscicides used, their advantages and disadvantages, the techniques and equipment required for their application and evaluation of effect as well as the biological control of snails is included.

  3. Molluscicide control of snail vectors of schistosomiasis

    OpenAIRE

    Cecília Pereira de Souza

    1995-01-01

    A review of the methodology recommended by the World Health Organization for the use of molluscicides for the control of snail vectors of schistosomiasis is presented. Discussion of the principle molluscicides used, their advantages and disadvantages, the techniques and equipment required for their application and evaluation of effect as well as the biological control of snails is included.

  4. Virtual Vector Machine for Bayesian Online Classification

    CERN Document Server

    Minka, Thomas P; Yuan,; Qi,

    2012-01-01

    In a typical online learning scenario, a learner is required to process a large data stream using a small memory buffer. Such a requirement is usually in conflict with a learner's primary pursuit of prediction accuracy. To address this dilemma, we introduce a novel Bayesian online classi cation algorithm, called the Virtual Vector Machine. The virtual vector machine allows you to smoothly trade-off prediction accuracy with memory size. The virtual vector machine summarizes the information contained in the preceding data stream by a Gaussian distribution over the classi cation weights plus a constant number of virtual data points. The virtual data points are designed to add extra non-Gaussian information about the classi cation weights. To maintain the constant number of virtual points, the virtual vector machine adds the current real data point into the virtual point set, merges two most similar virtual points into a new virtual point or deletes a virtual point that is far from the decision boundary. The info...

  5. Use of vectors in sequence analysis.

    Science.gov (United States)

    Ishikawa, T; Yamamoto, K; Yoshikura, H

    1987-10-01

    Applications of the vector diagram, a new type of representation of protein structure, in homology search of various proteins including oncogene products are presented. The method takes account of various kinds of information concerning the properties of amino acids, such as Chou and Fasman's probability data. The method can detect conformational similarities of proteins which may not be detected by the conventional programs.

  6. NLO vector boson production with light jets

    CERN Document Server

    Bern, Z; Dixon, L J; Cordero, F Febres; Forde, D; Gleisberg, T; Hoeche, S; Ita, H; Kosower, D A; Maitre, D; Ozeren, K

    2012-01-01

    In this contribution we present recent progress in the computation of next-to-leading order (NLO) QCD corrections for the production of an electroweak vector boson in association with jets at hadron colliders. We focus on results obtained using the virtual matrix element library BLACKHAT in conjunction with SHERPA, focusing on results relevant to understanding the background to top production.

  7. Ecology of parasite-vector interactions

    NARCIS (Netherlands)

    Takken, W.; Koenraadt, C.J.M.

    2013-01-01

    Vector-borne diseases continue to be one of the most important determinants affecting human and animal health. Large numbers of people suffer from diseases like malaria, dengue, filariasis and leishmaniasis, especially in the tropics. Whereas these diseases were eradicated from the temperate climate

  8. Teaching Universal Gravitation with Vector Games

    Science.gov (United States)

    Lowry, Matthew

    2008-01-01

    Like many high school and college physics teachers, I have found playing vector games to be a useful way of illustrating the concepts of inertia, velocity, and acceleration. Like many, I have also had difficulty in trying to get students to understand Newton's law of universal gravitation, specifically the inverse-square law and its application to…

  9. Closed-chain principal vector linkages

    NARCIS (Netherlands)

    Wijk, van der V.; Flores, Paulo; Viadero, Fernando

    2015-01-01

    For high-speed robotics dynamic balance is an important property for low base vibrations and short cycle times. To consider dynamic balance in the beginning of the design process of a manipulator, mechanism solutions can be synthesized from principal vector linkages, which are fundamental kinematic

  10. Vector Reflectometry in a Beam Waveguide

    CERN Document Server

    Eimer, Joseph R; Chuss, David T; Wollack, Edward J

    2011-01-01

    We present a one-port calibration technique for characterization of beam waveguide components with a vector network analyzer. This technique involves using a set of known delays to separate the responses of the instrument and the device under test. We demonstrate this technique by measuring the reflected performance of a millimeter-wave variable-delay polarization modulator.

  11. High performance computing on vector systems

    CERN Document Server

    Roller, Sabine

    2008-01-01

    Presents the developments in high-performance computing and simulation on modern supercomputer architectures. This book covers trends in hardware and software development in general and specifically the vector-based systems and heterogeneous architectures. It presents innovative fields like coupled multi-physics or multi-scale simulations.

  12. Weighted Twin Support Vector Machine with Universum

    Directory of Open Access Journals (Sweden)

    Shuxia Lu

    Full Text Available Universum is a new concept proposed recently, which is defined to be the sample that does not belong to any classes concerned. Support Vector Machine with Universum (..-SVM is a new algorithm, which can exploit Universum samples to improve the classifica ...

  13. Support Vector Machines for System Identification

    OpenAIRE

    Marconato, Anna; Gubian, Michele; Boni, Andrea; Petri, Dario

    2007-01-01

    In this document we propose the use of a widely known learning-from-examples paradigm, namely the Support Vector Machines for Regression (SVRs), for system identification problems. We start off with the identification of a simple linear system taken from the literature, and proceed with the non-linear case as a second step.

  14. Angry Birds Mathematics: Parabolas and Vectors

    Science.gov (United States)

    Lamb, John H.

    2013-01-01

    John Lamb, a professor of mathematics education and a teacher of high school precalculus, describes how he developed a way to use the elements of the game Angry Birds® as a platform to engage his students with the concepts of parabolas and vectors. The game could be categorized as a type of microworld game in which students interact with the…

  15. The Integration Order of Vector Autoregressive Processes

    DEFF Research Database (Denmark)

    Franchi, Massimo

    We show that the order of integration of a vector autoregressive process is equal to the difference between the multiplicity of the unit root in the characteristic equation and the multiplicity of the unit root in the adjoint matrix polynomial. The equivalence with the standard I(1) and I(2...

  16. Testing for vector autoregressive dynamics under heteroskedasticity

    NARCIS (Netherlands)

    C.M. Hafner (Christian); H. Herwartz

    2002-01-01

    textabstractIn this paper we introduce a bootstrap procedure to test parameter restrictions in vector autoregressive models which is robust in cases of conditionally heteroskedastic error terms. The adopted wild bootstrap method does not require any parametric specification of the volatility process

  17. Bayesian Vector Autoregressions with Stochastic Volatility

    NARCIS (Netherlands)

    Uhlig, H.F.H.V.S.

    1996-01-01

    This paper proposes a Bayesian approach to a vector autoregression with stochastic volatility, where the multiplicative evolution of the precision matrix is driven by a multivariate beta variate.Exact updating formulas are given to the nonlinear filtering of the precision matrix.Estimation of the au

  18. Anomalous effective lagrangians and vector resonance models

    NARCIS (Netherlands)

    Pallante, E.; Petronzio, R.

    1993-01-01

    Chiral lagrangians including vector resonances have been shown to saturate the finite part of some of the counterterms needed to regularize ordinary one-loop effective lagrangians of pseudoscalar interactions with external currents. The equivalence between different models has been discussed in the

  19. Lorentz transformation and vector field flows

    OpenAIRE

    Chiu, S. H.; Kuo, T. K.

    2003-01-01

    The parameter changes resulting from a combination of Lorentz transformation are shown to form vector field flows. The exact, finite Thomas rotation angle is determined and interpreted intuitively. Using phase portraits, the parameters evolution can be clearly visualized. In addition to identifying the fixed points, we obtain an analytic invariant, which correlates the evolution of parameters.

  20. Students' Difficulties with Vector Calculus in Electrodynamics

    Science.gov (United States)

    Bollen, Laurens; van Kampen, Paul; De Cock, Mieke

    2015-01-01

    Understanding Maxwell's equations in differential form is of great importance when studying the electrodynamic phenomena discussed in advanced electromagnetism courses. It is therefore necessary that students master the use of vector calculus in physical situations. In this light we investigated the difficulties second year students at KU Leuven…

  1. Lentiviral Vectors and Cystic Fibrosis Gene Therapy

    Directory of Open Access Journals (Sweden)

    Massimo Conese

    2010-01-01

    Full Text Available Cystic fibrosis (CF is a chronic autosomic recessive syndrome, caused by mutations in the CF Transmembrane Conductance Regulator (CFTR gene, a chloride channel expressed on the apical side of the airway epithelial cells. The lack of CFTR activity brings a dysregulated exchange of ions and water through the airway epithelium, one of the main aspects of CF lung disease pathophysiology. Lentiviral (LV vectors, of the Retroviridae family, show interesting properties for CF gene therapy, since they integrate into the host genome and allow long-lasting gene expression. Proof-of-principle that LV vectors can transduce the airway epithelium and correct the basic electrophysiological defect in CF mice has been given. Initial data also demonstrate that LV vectors can be repeatedly administered to the lung and do not give rise to a gross inflammatory process, although they can elicit a T cell-mediated response to the transgene. Future studies will clarify the efficacy and safety profile of LV vectors in new complex animal models with CF, such as ferrets and pigs.

  2. Nonlinear Versions of a Vector Maximal Principle

    CERN Document Server

    Turinici, Mihai

    2010-01-01

    Some nonlinear extensions of the vector maximality statement established by Goepfert, Tammer and Zalinescu [Nonl. Anal., 39 (2000), 909-922] are given. Basic instruments for these are the Brezis-Browder ordering principle [Advances Math., 21 (1976), 355-364] and its logical equivalent in Turinici [Libertas Math., 20 (2000), 161-172].

  3. Nonlinear Versions of a Vector Maximal Principle

    OpenAIRE

    Turinici, Mihai

    2010-01-01

    Some nonlinear extensions of the vector maximality statement established by Goepfert, Tammer and Zalinescu [Nonl. Anal., 39 (2000), 909-922] are given. Basic instruments for these are the Brezis-Browder ordering principle [Advances Math., 21 (1976), 355-364] and a (pseudometric) version of it obtained in Turinici [Demonstr. Math., 22 (1989), 213-228].

  4. Vector Product and an Integrable Dynamical System

    Institute of Scientific and Technical Information of China (English)

    Willi-Hans Steeb; Yorick Hardy; Igor Tanski

    2011-01-01

    We study an autonomous system of first order ordinary differential equations based on the vector product. We show that the system is completely integrable by constructing the first integrals. The connection with Nambu mechanics is established. The extension to higher dimensions is also discussed.

  5. [Conflicts and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, Ib Christian

    2010-01-01

    Based on literature and personal experiences, vector-borne diseases and conflicts are reviewed. Simple rapid diagnostic tests for three important parasitoses are available. Resort is often made to case definitions and to presumptive treatment. Resistance is an emerging problem. Vaccines are still...

  6. Demonstration of a Vector Velocity Technique

    DEFF Research Database (Denmark)

    Hansen, Peter Møller; Pedersen, Mads M.; Hansen, Kristoffer L.;

    2011-01-01

    With conventional Doppler ultrasound it is not possible to estimate direction and velocity of blood flow, when the angle of insonation exceeds 60–70°. Transverse oscillation is an angle independent vector velocity technique which is now implemented on a conventional ultrasound scanner...

  7. Vector Volume Flow in Arteriovenous Fistulas

    DEFF Research Database (Denmark)

    Hansen, Peter Møller; Heerwagen, Søren; Pedersen, Mads Møller;

    2013-01-01

    , but is very challenging due to the angle dependency of the Doppler technique and the anatomy of the fistula. The angle independent vector ultrasound technique Transverse Oscillation provides a new and more intuitive way to measure volume flow in an arteriovenous fistula. In this paper the Transverse...

  8. η-Invariant and Flat Vector Bundles

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    We present an alternate definition of the mod Z component of the AtiyahPatodi-Singer η invariant associated to (not necessary unitary) fiat vector bundles, which identifies explicitly its real and imaginary parts. This is done by combining a deformation of flat connections introduced in a previous paper with the analytic continuation procedure appearing in the original article of Atiyah, Parodi and Singer.

  9. Global traffic and disease vector dispersal.

    Science.gov (United States)

    Tatem, Andrew J; Hay, Simon I; Rogers, David J

    2006-04-18

    The expansion of global air travel and seaborne trade overcomes geographic barriers to insect disease vectors, enabling them to move great distances in short periods of time. Here we apply a coupled human-environment framework to describe the historical spread of Aedes albopictus, a competent mosquito vector of 22 arboviruses in the laboratory. We contrast this dispersal with the relatively unchanged distribution of Anopheles gambiae and examine possible future movements of this malaria vector. We use a comprehensive database of international ship and aircraft traffic movements, combined with climatic information, to remap the global transportation network in terms of disease vector suitability and accessibility. The expansion of the range of Ae. albopictus proved to be surprisingly predictable using this combination of climate and traffic data. Traffic volumes were more than twice as high on shipping routes running from the historical distribution of Ae. albopictus to ports where it has established in comparison with routes to climatically similar ports where it has yet to invade. In contrast, An. gambiae has rarely spread from Africa, which we suggest is partly due to the low volume of sea traffic from the continent and, until very recently, a European destination for most flights.

  10. Domain wall fermions in vector gauge theories

    OpenAIRE

    Blum, T.

    1998-01-01

    I review domain wall fermions in vector gauge theories. Following a brief introduction, the status of lattice calculations using domain wall fermions is presented. I focus on results from QCD, including the light quark masses and spectrum, weak matrix elements, the $n_f=2$ finite temperature phase transition, and topology and zero modes and conclude with topics for future study.

  11. Vector biology prospects in dengue research

    Directory of Open Access Journals (Sweden)

    Louis Lambrechts

    2012-12-01

    Full Text Available We argue that using more natural blood feeding methods to study mosquito vector competence for dengue viruses and exploring the effect of viral infection on other mosquito life-history traits that influence vectorial capacity will significantly advance our understanding of dengue epidemiology.

  12. Vector biology prospects in dengue research

    OpenAIRE

    Louis Lambrechts; Anna-Bella Failloux

    2012-01-01

    We argue that using more natural blood feeding methods to study mosquito vector competence for dengue viruses and exploring the effect of viral infection on other mosquito life-history traits that influence vectorial capacity will significantly advance our understanding of dengue epidemiology.

  13. Efficient Multiplicative Updates for Support Vector Machines

    DEFF Research Database (Denmark)

    Potluru, Vamsi K.; Plis, Sergie N; Mørup, Morten;

    2009-01-01

    The dual formulation of the support vector machine (SVM) objective function is an instance of a nonnegative quadratic programming problem. We reformulate the SVM objective function as a matrix factorization problem which establishes a connection with the regularized nonnegative matrix factorizati...

  14. Malaria vector control: current and future strategies

    NARCIS (Netherlands)

    Takken, W.; Knols, B.G.J.

    2009-01-01

    The recently announced call for malaria eradication represents a new page in the history of this disease. This has been triggered by remarkable reductions in malaria resulting from combined application of effective drugs and vector control. However, this strategy is threatened by development of inse

  15. A review of learning vector quantization classifiers

    CERN Document Server

    Nova, David

    2015-01-01

    In this work we present a review of the state of the art of Learning Vector Quantization (LVQ) classifiers. A taxonomy is proposed which integrates the most relevant LVQ approaches to date. The main concepts associated with modern LVQ approaches are defined. A comparison is made among eleven LVQ classifiers using one real-world and two artificial datasets.

  16. Adaptive Vector Control of Induction Motor

    Directory of Open Access Journals (Sweden)

    O. F. Opeiko

    2012-01-01

    Full Text Available A synthesis of adaptive PID controller has been executed for flux linkage and speed channels of a vector control system for an induction short-circuited motor. While using an imitation simulation method results of a synthesized system analysis show that the adaptive PID controller has some advantages under conditions of parametric disturbances affecting the object.

  17. Word's vector representations meet machine translation

    OpenAIRE

    Martínez Garcia, Eva; España Bonet, Cristina; Tiedemann, Jörg; Márquez Villodre, Luís

    2014-01-01

    Distributed vector representations of words are useful in various NLP tasks. We briefly review the CBOW approach and propose a bilingual application of this architecture with the aim to improve consistency and coherence of Machine Translation. The primary goal of the bilingual extension is to handle ambiguous words for which the different senses are conflated in the monolingual setup.

  18. Isotropy theorem for cosmological vector fields

    CERN Document Server

    Cembranos, J A R; Maroto, A L; Jareño, S J Núñez

    2012-01-01

    We consider homogeneous abelian vector fields in an expanding universe. We find a mechanical analogy in which the system behaves as a particle moving in three dimensions under the action of a central potential. In the case of bounded and rapid evolution compared to the rate of expansion, we show by making use of the virial theorem that for arbitrary potential and polarization pattern, the average energy-momentum tensor is always diagonal and isotropic despite the intrinsic anisotropic evolution of the vector field. For simple power-law potentials of the form V=\\lambda (A^\\mu A_\\mu)^n, the average equation of state is found to be w=(n-1)/(n+1). This implies that vector coherent oscillations could act as natural dark matter or dark energy candidates. Finally, we show that under very general conditions, the average energy-momentum tensor of a rapidly evolving bounded vector field in any background geometry is always isotropic and has the perfect fluid form for any locally inertial observer.

  19. Classical lifting processes and multiplicative vector fields

    OpenAIRE

    Mackenzie, Kirill; Xu, Ping

    1997-01-01

    We extend the calculus of multiplicative vector fields and differential forms and their intrinsic derivatives from Lie groups to Lie groupoids; this generalization turns out to include also the classical process of complete lifting from arbitrary manifolds to tangent and cotangent bundles. Using this calculus we give a new description of the Lie bialgebroid structure associated with a Poisson groupoid.

  20. Generalized vector calculus on convex domain

    Science.gov (United States)

    Agrawal, Om P.; Xu, Yufeng

    2015-06-01

    In this paper, we apply recently proposed generalized integral and differential operators to develop generalized vector calculus and generalized variational calculus for problems defined over a convex domain. In particular, we present some generalization of Green's and Gauss divergence theorems involving some new operators, and apply these theorems to generalized variational calculus. For fractional power kernels, the formulation leads to fractional vector calculus and fractional variational calculus for problems defined over a convex domain. In special cases, when certain parameters take integer values, we obtain formulations for integer order problems. Two examples are presented to demonstrate applications of the generalized variational calculus which utilize the generalized vector calculus developed in the paper. The first example leads to a generalized partial differential equation and the second example leads to a generalized eigenvalue problem, both in two dimensional convex domains. We solve the generalized partial differential equation by using polynomial approximation. A special case of the second example is a generalized isoperimetric problem. We find an approximate solution to this problem. Many physical problems containing integer order integrals and derivatives are defined over arbitrary domains. We speculate that future problems containing fractional and generalized integrals and derivatives in fractional mechanics will be defined over arbitrary domains, and therefore, a general variational calculus incorporating a general vector calculus will be needed for these problems. This research is our first attempt in that direction.

  1. A Lesson in Vectors "Plain" and Simple

    Science.gov (United States)

    Bradshaw, David M.

    2004-01-01

    The United States Military Academy (USMA) has a four course core mathematics curriculum that is studied by all students. The third course is MA205, Calculus II; a multivariate calculus course filled with practical applications. During a Problem Solving Lab (PSL), students participated in a hands-on exercise with multiple vector operations,…

  2. Robustifying Descriptor Instability using Fisher Vectors

    NARCIS (Netherlands)

    I. Everts; J.C. van Gemert; T. Mensink; T. Gevers

    2014-01-01

    Many computer vision applications, including image classification, matching, and retrieval use global image representations, such as the Fisher vector, to encode a set of local image patches. To describe these patches, many local descriptors have been designed to be robust against lighting changes a

  3. Bias-correction in vector autoregressive models

    DEFF Research Database (Denmark)

    Engsted, Tom; Pedersen, Thomas Quistgaard

    2014-01-01

    We analyze the properties of various methods for bias-correcting parameter estimates in both stationary and non-stationary vector autoregressive models. First, we show that two analytical bias formulas from the existing literature are in fact identical. Next, based on a detailed simulation study,...

  4. Arabic Text Classification Using Support Vector Machines

    NARCIS (Netherlands)

    Gharib, Tarek Fouad; Habib, Mena Badieh; Fayed, Zaki Taha; Zhu, Qiang

    2009-01-01

    Text classification (TC) is the process of classifying documents into a predefined set of categories based on their content. Arabic language is highly inflectional and derivational language which makes text mining a complex task. In this paper we applied the Support Vector Machines (SVM) model in cl

  5. Topology based methods for vector field comparisons

    Science.gov (United States)

    Batra, Rajesh Kumar

    Vector fields are commonly found in almost all branches of the physical sciences. Aerodynamics, dynamical systems, electromagnetism, and global climate modeling are a few examples. These multivariate data fields are often large, and no general, automated method exists for comparing these fields. Existing methods require either subjective visual judgments, or data interface compatibility, or domain specific knowledge. A topology based method intrinsically eliminates all of the above limitations and has the additional advantage of significantly compressing the vector field by representing only key features of the flow. Therefore, large databases are compactly represented and quickly searched. Topology is a natural framework for the study of many vector fields. It provides rules of an organizing principle, a flow grammar, that can describe and connect together the properties common to flows. Helman and Hesselink first introduced automated methods to extract and visualize this grammar. This work extends their method by introducing automated methods for vector topology comparison. Basic two-dimensional flows are first compared. The theory is extended to compare three-dimensional flow fields and the topology on no-slip surfaces. Concepts from graph theory and linear programming are utilized to solve these problems. Finally, the first automated method for higher order singularity comparisons is introduced using mathematical theories from geometric (Clifford) algebra.

  6. Image compression using address-vector quantization

    Science.gov (United States)

    Nasrabadi, Nasser M.; Feng, Yushu

    1990-12-01

    A novel vector quantization scheme, the address-vector quantizer (A-VQ), is proposed which exploits the interblock correlation by encoding a group of blocks together using an address-codebook (AC). The AC is a set of address-codevectors (ACVs), each representing a combination of addresses or indices. Each element of the ACV is an address of an entry in the LBG-codebook, representing a vector-quantized block. The AC consists of an active (addressable) region and an inactive (nonaddressable) region. During encoding the ACVs in the AC are reordered adaptively to bring the most probable ACVs into the active region. When encoding an ACV, the active region is checked, and if such an address combination exists, its index is transmitted to the receiver. Otherwise, the address of each block is transmitted individually. The SNR of the images encoded by the A-VQ method is the same as that of a memoryless vector quantizer, but the bit rate is by a factor of approximately two.

  7. Singular hermitian metrics on vector bundles

    CERN Document Server

    De Cataldo, M A A

    1997-01-01

    We introduce a notion of singular hermitian metrics (s.h.m.) for holomorphic vector bundles and define positivity in view of $L^2$-estimates. Associated with a suitably positive s.h.m. there is a (coherent) sheaf 0-th kernel of a certain $d''$-complex. We prove a vanishing theorem for the cohomology of this sheaf. All this generalizes to the case of higher rank known results of Nadel for the case of line bundles. We introduce a new semi-positivity notion, $t$-nefness, for vector bundles, establish some of its basic properties and prove that on curves it coincides with ordinary nefness. We particularize the results on s.h.m. to the case of vector bundles of the form $E=F \\otimes L$, where $F$ is a $t$-nef vector bundle and $L$ is a positive (in the sense of currents) line bundle. As applications we generalize to the higher rank case 1) Kawamata-Viehweg Vanishing Theorem, 2) the effective results concerning the global generation of jets for the adjoint to powers of ample line bundles, and 3) Matsusaka Big Theor...

  8. Bethe vectors for XXX-spin chain

    Science.gov (United States)

    Burdík, Čestmír; Fuksa, Jan; Isaev, Alexei

    2014-11-01

    The paper deals with algebraic Bethe ansatz for XXX-spin chain. Generators of Yang-Baxter algebra are expressed in basis of free fermions and used to calculate explicit form of Bethe vectors. Their relation to N-component models is used to prove conjecture about their form in general. Some remarks on inhomogeneous XXX-spin chain are included.

  9. $h$-vectors of small matroid complexes

    OpenAIRE

    DeLoera, Jesus; Kemper, Yvonne; Klee, Steven

    2011-01-01

    Stanley conjectured in 1977 that the $h$-vector of a matroid simplicial complex is a pure $O$-sequence. We give simple constructive proofs that the conjecture is true for matroids of rank less than or equal to 3, and corank 2. We used computers to verify that Stanley's conjecture holds for all matroids on at most nine elements.

  10. Bacteriophage lambda as a cloning vector.

    Science.gov (United States)

    Chauthaiwale, V M; Therwath, A; Deshpande, V V

    1992-12-01

    Extensive research has been directed toward the development of multipurpose lambda vectors for cloning ever since the potential of using coliphage lambda as a cloning vector was recognized in the late 1970s. An understanding of the intrinsic molecular organization and of the genetic events which determine lysis or lysogeny in lambda has allowed investigators to modify it to suit the specific requirements of gene manipulations. Unwanted restriction sites have been altered and arranged together into suitable polylinkers. The development of a highly efficient in vitro packaging system has permitted the introduction of chimeric molecules into hosts. Biological containment of recombinants has been achieved by introducing amber mutations into the lambda genome and by using specific amber suppressor hosts. Taking advantage of the limited range of genome size (78 to 105% of the wild-type size) for its efficient packaging, an array of vectors has been devised to accommodate inserts of a wide size range, the limit being 24 kbp in Charon 40. The central dispensable fragment of the lambda genome can be replaced by a fragment of heterologous DNA, leading to the construction of replacement vectors such as Charon and EMBL. Alternatively, small DNA fragments can be inserted without removing the dispensable region of the lambda genome, as in lambda gt10 and lambda gt11 vectors. In addition, the introduction of many other desirable properties, such as NotI and SfiI sites in polylinkers (e.g., lambda gt22), T7 and T3 promoters for the in vitro transcription (e.g., lambda DASH), and the mechanism for in vivo excision of the intact insert (e.g., lambda ZAP), has facilitated both cloning and subsequent analysis. In most cases, the recombinants can be differentiated from the parental phages by their altered phenotype. Libraries constructed in lambda vectors are screened easily with antibody or nucleic acid probes since several thousand clones can be plated on a single petri dish. Besides

  11. VECTORS OF MALARIA AND FILARIASIS IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Hoedojo Hoedojo

    2012-09-01

    Full Text Available Malaria at present is still one of the important mosquito-borne diseases in Indonesia. The disease is widespread all over the country and involves nearly all islands. Sixteen Anopheles species have been reconfirmed as malaria vectors. They were distributed geographi­cally as follows: Coastal areas and lagoons ------------------------------------- An sundaicus and An.subpictus Cultivated ricefields and swampy areas -------------------- An.aconitus, An.barbirostris, An.nigerrimus and An.sinensis Forest inland areas in shaded temporary pools, muddy animal wallows and hoof-prints -------------------------------------------------------- An.balabacensis, An.bancrofti, An.farauti, An.koliensis and An.punctulatus Swamp forest edge in ditches with vegeta- ---------------- An.letifer and An.ludlowae don Hilly areas in seepages, streams and clear moving water ---------------------------------------------- Anflavirostris, An.maculatus and Anminimus.   The species (of most general importance is An.sundaicus, which is restricted by its preference for brackish water and is prevalent in coastal areas of Java. Their types in behaviour of An.sundaicus appear as follows : 1. An.sundaicus in South Coast of Java in general. This species is essentially anthropophilic, exophagic and rests outdoor. It shows susceptible to DDT. 2. An.sundaicus in Cilacap, Central Java. This mosquito is a pure anthropophilic form. It bites man in houses and outdoors, rests indoors and is known resistant to DDT. 3. An.sundaicus in Yogyakarta and Purworejo, Central Java. This mosquito is a strong zoophilic species. It rests and prefers to bite outdoors and shows tolerance to DDT. Human filariasis in Indonesia is the result of infection by three endemic species, namely, Wuchereria bancrofti, Brugia malayi, and Brugia timori.W.bancrofti infection is found in both urban and rural areas. Twenty species of mosquitoes are confirmed as filariasis vectors. The urban type bancroftian filariasis

  12. Nonlinear Growth of Singular Vector Based Perturbations

    Science.gov (United States)

    Reynolds, C. A.

    2002-12-01

    The nonlinearity of singular vector-based perturbation growth is examined within the context of a global atmospheric forecast model. The characteristics of these nonlinearities and their impact on the utility of SV-based diagnostics are assessed both qualitatively and quantitatively. Nonlinearities are quantified by examining the symmetry of evolving positive and negative "twin" perturbations. Perturbations initially scaled to be consistent with estimates of analysis uncertainty become significantly nonlinear by 12 hours. However, the relative magnitude of the nonlinearities is a strong function of scale and metric. Small scales become nonlinear very quickly while synoptic scales can remain significantly linear out to three day. Small shifts between positive and negative perturbations can result in significant nonlinearities even when the basic anomaly patterns are quite similar. Thus, singular vectors may be qualitatively useful even when nonlinearities are large. Post-time pseudo-inverse experiments show that despite significant nonlinear perturbation growth, the nonlinear forecast corrections are similar to the expected linear corrections, even at 72 hours. When the nonlinear correction does differ significantly from the expected linear correction, the nonlinear correction is usually better, indicating that in some cases the pseudo-inverse correction effectively suppresses error growth outside the subspace defined by the leading (dry) singular vectors. Because a significant portion of the nonlinear growth occurs outside of the dry singular vector subspace, an a priori nonlinearity index based on the full perturbations is not a good predictor of when pseudo-inverse based corrections will be ineffective. However, one can construct a reasonable predictor of pseudo-inverse ineffectiveness by focusing on nonlinearities in the synoptic scales or in the singular vector subspace only.

  13. Induction motor modelling for vector control purposes

    Energy Technology Data Exchange (ETDEWEB)

    Popescu, M.

    2000-07-01

    Widely used in many industrial applications, the induction motors represent the starting point when an electrical drive system has to be designed. In modern control theory, the induction motor is described by different mathematical models, according to the employed control method. In the symmetrical three-phase version or in the unsymmetrical two-phase version, this electrical motor type can be associated with vector control strategy. Through this control method, the induction motor operation can be analysed in a similar way to a DC motor. The goal of this research is to summarize the existing models and to develop new models, in order to obtain a unified approach on modelling of the induction machines for vector control purposes. Starting from vector control principles, the work suggests the d-q axes unified approach for all types of the induction motors. However, the space vector analysis is presented as a strong tool in modelling of the symmetrical induction machines. When an electrical motor is viewed as a mathematical system, with inputs and outputs, it can be analysed and described in multiple ways, considering different reference frames and state-space variables. All the mathematical possible models are illustrated in this report. The suggestions for what model is suitable for what application, are defined as well. As the practical implementation of the vector control strategies require digital signal processors (DSP), from the continuous time domain models are derived the discrete time domain models. The discrete models permit the implementation of the mathematical model of the induction motors, in order to obtain high efficiency sensorless drives. The stability of these various models is analysed. (orig.)

  14. Switching non-local vector median filter

    Science.gov (United States)

    Matsuoka, Jyohei; Koga, Takanori; Suetake, Noriaki; Uchino, Eiji

    2016-04-01

    This paper describes a novel image filtering method that removes random-valued impulse noise superimposed on a natural color image. In impulse noise removal, it is essential to employ a switching-type filtering method, as used in the well-known switching median filter, to preserve the detail of an original image with good quality. In color image filtering, it is generally preferable to deal with the red (R), green (G), and blue (B) components of each pixel of a color image as elements of a vectorized signal, as in the well-known vector median filter, rather than as component-wise signals to prevent a color shift after filtering. By taking these fundamentals into consideration, we propose a switching-type vector median filter with non-local processing that mainly consists of a noise detector and a noise removal filter. Concretely, we propose a noise detector that proactively detects noise-corrupted pixels by focusing attention on the isolation tendencies of pixels of interest not in an input image but in difference images between RGB components. Furthermore, as the noise removal filter, we propose an extended version of the non-local median filter, we proposed previously for grayscale image processing, named the non-local vector median filter, which is designed for color image processing. The proposed method realizes a superior balance between the preservation of detail and impulse noise removal by proactive noise detection and non-local switching vector median filtering, respectively. The effectiveness and validity of the proposed method are verified in a series of experiments using natural color images.

  15. Vector-Mediated In Vivo Antibody Expression.

    Science.gov (United States)

    Schnepp, Bruce C; Johnson, Philip R

    2014-08-01

    This article focuses on a novel vaccine strategy known as vector-mediated antibody gene transfer, with a particular focus on human immunodeficiency virus (HIV). This strategy provides a solution to the problem of current vaccines that fail to generate neutralizing antibodies to prevent HIV-1 infection and AIDS. Antibody gene transfer allows for predetermination of antibody affinity and specificity prior to "immunization" and avoids the need for an active humoral immune response against the HIV envelope protein. This approach uses recombinant adeno-associated viral (rAAV) vectors, which have been shown to transduce muscle with high efficiency and direct the long-term expression of a variety of transgenes, to deliver the gene encoding a broadly neutralizing antibody into the muscle. Following rAAV vector gene delivery, the broadly neutralizing antibodies are endogenously synthesized in myofibers and passively distributed to the circulatory system. This is an improvement over classical passive immunization strategies that administer antibody proteins to the host to provide protection from infection. Vector-mediated gene transfer studies in mice and monkeys with anti-HIV and simian immunodeficiency virus (SIV)-neutralizing antibodies demonstrated long-lasting neutralizing activity in serum with complete protection against intravenous challenge with virulent HIV and SIV. These results indicate that existing potent anti-HIV antibodies can be rapidly moved into the clinic. However, this methodology need not be confined to HIV. The general strategy of vector-mediated antibody gene transfer can be applied to other difficult vaccine targets such as hepatitis C virus, malaria, respiratory syncytial virus, and tuberculosis. PMID:26104192

  16. Construction of Yeast Vectors with Resistance to Geneticin

    Institute of Scientific and Technical Information of China (English)

    林会兰; 张广; 周全; 陈国强

    2002-01-01

    Two Escherichia coli-Saccharomyces cerevisiae shuttle vectors containing a resistance marker to geneticin (G418) are constructed. Both vectors contain a kanamycin-resistant marker (KanMX4) module coding aminoglycoside 3'-phosphotransferase (APH) that renders E. coli resistant to kanamycin and S. cerevisiae to geneticin. These vectors overcome the shortage of the conventional yeast vectors bearing HIS3, TRP1, LEU2, and URA3 modules as selection markers, which require hosts to be auxotrophic. Green fluorescent protein (GFP) is used as the reporter to examine the functions of the vectors. The vectors are powerful tools for the convenient cloning and controlled expression of genes in most S. cerevisiae strains.

  17. Vector and axial vector mesons in a nonlocal chiral quark model

    Science.gov (United States)

    Izzo Villafañe, M. F.; Gómez Dumm, D.; Scoccola, N. N.

    2016-09-01

    Basic features of nonstrange vector and axial vector mesons are analyzed in the framework of a chiral quark model that includes nonlocal four-fermion couplings. Unknown model parameters are determined from some input values of masses and decay constants, while nonlocal form factors are taken from a fit to lattice QCD results for effective quark propagators. Numerical results show a good agreement with the observed meson phenomenology.

  18. Dispersive approach to QCD: tau lepton hadronic decay in vector and axial-vector channels

    CERN Document Server

    Nesterenko, A V

    2014-01-01

    The dispersive approach to QCD, which extends the applicability range of perturbation theory towards the infrared domain, is developed. This approach properly accounts for the intrinsically nonperturbative constraints, which originate in the low-energy kinematic restrictions on pertinent strong interaction processes. The dispersive approach proves to be capable of describing OPAL (update 2012) and ALEPH (update 2014) experimental data on inclusive tau lepton hadronic decay in vector and axial-vector channels in a self-consistent way.

  19. Vector and axial vector mesons in a nonlocal chiral quark model

    CERN Document Server

    Villafañe, M F Izzo; Scoccola, N N

    2016-01-01

    Basic features of nonstrange vector and axial vector mesons are analyzed in the framework of a chiral quark model that includes nonlocal four fermion couplings. Unknown model parameters are determined from some input values of masses and decay constants, while nonlocal form factors are taken from a fit to lattice QCD results for effective quark propagators. Numerical results show a good agreement with the observed meson phenomenology.

  20. Charmless Hadronic B Decays into Vector, Axial Vector and Tensor Final States at BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Gandini, Paolo; /Milan U. /INFN, Milan

    2012-04-06

    We present experimental measurements of branching fraction and longitudinal polarization fraction in charmless hadronic B decays into vector, axial vector and tensor final states with the final dataset of BABAR. Measurements of such kind of decays are a powerful tool both to test the Standard Model and search possible sources of new physics. In this document we present a short review of the last experimental results at BABAR concerning charmless quasi two-body decays in final states containing particles with spin 1 or spin 2 and different parities. This kind of decays has received considerable theoretical interest in the last few years and this particular attention has led to interesting experimental results at the current b-factories. In fact, the study of longitudinal polarization fraction f{sub L} in charmless B decays to vector vector (VV), vector axial-vector (VA) and axial-vector axial-vector (AA) mesons provides information on the underlying helicity structure of the decay mechanism. Naive helicity conservation arguments predict a dominant longitudinal polarization fraction f{sub L} {approx} 1 for both tree and penguin dominated decays and this pattern seems to be confirmed by tree-dominated B {yields} {rho}{rho} and B{sup +} {yields} {Omega}{rho}{sup +} decays. Other penguin dominated decays, instead, show a different behavior: the measured value of f{sub L} {approx} 0.5 in B {yields} {phi}K* decays is in contrast with naive Standard Model (SM) calculations. Several solutions have been proposed such as the introduction of non-factorizable terms and penguin-annihilation amplitudes, while other explanations invoke new physics. New modes have been investigated to shed more light on the problem.

  1. Vector adaptive predictive coder for speech and audio

    Science.gov (United States)

    Chen, Juin-Hwey (Inventor); Gersho, Allen (Inventor)

    1990-01-01

    A real-time vector adaptive predictive coder which approximates each vector of K speech samples by using each of M fixed vectors in a first codebook to excite a time-varying synthesis filter and picking the vector that minimizes distortion. Predictive analysis for each frame determines parameters used for computing from vectors in the first codebook zero-state response vectors that are stored at the same address (index) in a second codebook. Encoding of input speech vectors s.sub.n is then carried out using the second codebook. When the vector that minimizes distortion is found, its index is transmitted to a decoder which has a codebook identical to the first codebook of the decoder. There the index is used to read out a vector that is used to synthesize an output speech vector s.sub.n. The parameters used in the encoder are quantized, for example by using a table, and the indices are transmitted to the decoder where they are decoded to specify transfer characteristics of filters used in producing the vector s.sub.n from the receiver codebook vector selected by the vector index transmitted.

  2. Ultrasound Vector Flow Imaging: Part I: Sequential Systems

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Nikolov, Svetoslav Ivanov; Yu, Alfred C. H.;

    2016-01-01

    The paper gives a review of the most important methods for blood velocity vector flow imaging (VFI) for conventional, sequential data acquisition. This includes multibeam methods, speckle tracking, transverse oscillation, color flow mapping derived vector flow imaging, directional beamforming...

  3. Tensor calculus for the vector multiplet coupled to supergravity

    International Nuclear Information System (INIS)

    An invariant coupling of a local vector multiplet to supergravity is constructed in analogy with the D term invariant of global supersymmetry. The rules for combining local vector and chiral scalar multiplets of opposite chirality are given. (Auth.)

  4. Support Vector Machine%支持向量机

    Institute of Scientific and Technical Information of China (English)

    张浩然; 韩正之; 李昌刚

    2002-01-01

    This paper gives a introduction of the basic ideas, basic theory, key techniques, and application of the sup-port vector machine (SVM), and indicates the similarities and differences between support vector machines and neuralnetworks.

  5. Canine vector-borne diseases in Brazil

    Directory of Open Access Journals (Sweden)

    Dantas-Torres Filipe

    2008-08-01

    Full Text Available Abstract Canine vector-borne diseases (CVBDs are highly prevalent in Brazil and represent a challenge to veterinarians and public health workers, since some diseases are of great zoonotic potential. Dogs are affected by many protozoa (e.g., Babesia vogeli, Leishmania infantum, and Trypanosoma cruzi, bacteria (e.g., Anaplasma platys and Ehrlichia canis, and helminths (e.g., Dirofilaria immitis and Dipylidium caninum that are transmitted by a diverse range of arthropod vectors, including ticks, fleas, lice, triatomines, mosquitoes, tabanids, and phlebotomine sand flies. This article focuses on several aspects (etiology, transmission, distribution, prevalence, risk factors, diagnosis, control, prevention, and public health significance of CVBDs in Brazil and discusses research gaps to be addressed in future studies.

  6. Vectorized image segmentation via trixel agglomeration

    Science.gov (United States)

    Prasad, Lakshman; Skourikhine, Alexei N.

    2006-10-24

    A computer implemented method transforms an image comprised of pixels into a vectorized image specified by a plurality of polygons that can be subsequently used to aid in image processing and understanding. The pixelated image is processed to extract edge pixels that separate different colors and a constrained Delaunay triangulation of the edge pixels forms a plurality of triangles having edges that cover the pixelated image. A color for each one of the plurality of triangles is determined from the color pixels within each triangle. A filter is formed with a set of grouping rules related to features of the pixelated image and applied to the plurality of triangle edges to merge adjacent triangles consistent with the filter into polygons having a plurality of vertices. The pixelated image may be then reformed into an array of the polygons, that can be represented collectively and efficiently by standard vector image.

  7. Lepton flavor violation with light vector bosons

    Directory of Open Access Journals (Sweden)

    Julian Heeck

    2016-07-01

    Full Text Available New sub-GeV vector bosons with couplings to muons but not electrons have been discussed in order to explain the muon's magnetic moment, the gap of high-energy neutrinos in IceCube or the proton radius puzzle. If such a light Z′ not only violates lepton universality but also lepton flavor, as expected for example from the recent hint for h→μτ at CMS, the two-body decay mode τ→μZ′ opens up and for MZ′<2mμ gives better constraints than τ→3μ already with 20-year-old ARGUS limits. We discuss the general prospects and motivation of light vector bosons with lepton-flavor-violating couplings.

  8. Vector mesons in strongly interacting matter

    Indian Academy of Sciences (India)

    Volker Metag

    2010-08-01

    Properties of hadrons in strongly interacting matter provide a link between quantum chromodynamics in the strong coupling regime and experimental observables. QCD sum rules show that changes in chiral and higher-order condensates, partially associated with a restoration of chiral symmetry in the nuclear medium, will lead to significant changes in the low-energy spectrum of hadrons. Heavy-ion collisions and reactions with elementary probes have been used to extract experimental information on in-medium properties of hadrons. Results on the light vector mesons ρ, , and , are summarized and compared. Almost all experiments report a softening of the spectral functions with increases in width depending on the density and temperature of the hadronic environment. No evidence for mass shifts is found in majority of the experiments. Remaining inconsistencies among experimental results demonstrate the need for further measurements with higher statistics and inrceased acceptance in particular for low-momentum vector mesons.

  9. Dual Vector Spaces and Physical Singularities

    Science.gov (United States)

    Rowlands, Peter

    Though we often refer to 3-D vector space as constructed from points, there is no mechanism from within its definition for doing this. In particular, space, on its own, cannot accommodate the singularities that we call fundamental particles. This requires a commutative combination of space as we know it with another 3-D vector space, which is dual to the first (in a physical sense). The combination of the two spaces generates a nilpotent quantum mechanics/quantum field theory, which incorporates exact supersymmetry and ultimately removes the anomalies due to self-interaction. Among the many natural consequences of the dual space formalism are half-integral spin for fermions, zitterbewegung, Berry phase and a zero norm Berwald-Moor metric for fermionic states.

  10. SIT for African malaria vectors: Epilogue

    Directory of Open Access Journals (Sweden)

    Townson Harold

    2009-11-01

    Full Text Available Abstract As a result of increased support and the diligent application of new and conventional anti-malaria tools, significant reductions in malaria transmission are being accomplished. Historical and current evolutionary responses of vectors and parasites to malaria interventions demonstrate that it is unwise to assume that a limited suite of tools will remain effective indefinitely, thus efforts to develop new interventions should continue. This collection of manuscripts surveys the prospects and technical challenges for applying a novel tool, the sterile insect technique (SIT, against mosquitoes that transmit malaria. The method has been very successful against many agricultural pest insects in area-wide programs, but demonstrations against malaria vectors have not been sufficient to determine its potential relative to current alternatives, much of which will hinge ultimately upon cost. These manuscripts provide an overview of current efforts to develop SIT and identify key research issues that remain.

  11. Genetically engineering adenoviral vectors for gene therapy.

    Science.gov (United States)

    Coughlan, Lynda

    2014-01-01

    Adenoviral (Ad) vectors are commonly used for various gene therapy applications. Significant advances in the genetic engineering of Ad vectors in recent years has highlighted their potential for the treatment of metastatic disease. There are several methods to genetically modify the Ad genome to incorporate retargeting peptides which will redirect the natural tropism of the viruses, including homologous recombination in bacteria or yeast. However, homologous recombination in yeast is highly efficient and can be achieved without the need for extensive cloning strategies. In addition, the method does not rely on the presence of unique restriction sites within the Ad genome and the reagents required for this method are widely available and inexpensive. Large plasmids containing the entire adenoviral genome (~36 kbp) can be modified within Saccharomyces cerevisiae yeast and genomes easily rescued in Escherichia coli hosts for analysis or amplification. A method for two-step homologous recombination in yeast is described in this chapter.

  12. All-Optical Vector Atomic Magnetometer

    CERN Document Server

    Patton, B; Hovde, D C; Budker, D

    2014-01-01

    We demonstrate an all-optical magnetometer capable of measuring the magnitude and direction of a magnetic field using nonlinear magneto-optical rotation in a cesium vapor. Vector capability is added by effective modulation of the field along orthogonal axes and subsequent demodulation of the magnetic-resonance frequency. This modulation is provided by the AC Stark shift induced by circularly polarized laser beams. The sensor exhibits a demonstrated rms noise floor of 50 fT/Hz^(1/2) in measurement of the field magnitude and 0.5 mrad/Hz^(1/2) in the field direction; elimination of technical noise would improve these sensitivities to 12 fT/Hz^(1/2) and 5 microrad/Hz^(1/2), respectively. Applications for a precise all-optical vector magnetometer would include magnetically sensitive fundamental physics experiments, such as the search for a permanent electric dipole moment of the neutron.

  13. Elements of mathematics topological vector spaces

    CERN Document Server

    Bourbaki, Nicolas

    2003-01-01

    This is a softcover reprint of the English translation of 1987 of the second edition of Bourbaki's Espaces Vectoriels Topologiques (1981). This second edition is a brand new book and completely supersedes the original version of nearly 30 years ago. But a lot of the material has been rearranged, rewritten, or replaced by a more up-to-date exposition, and a good deal of new material has been incorporated in this book, all reflecting the progress made in the field during the last three decades. Table of Contents. Chapter I: Topological vector spaces over a valued field. Chapter II: Convex sets and locally convex spaces. Chapter III: Spaces of continuous linear mappings. Chapter IV: Duality in topological vector spaces. Chapter V: Hilbert spaces (elementary theory). Finally, there are the usual "historical note", bibliography, index of notation, index of terminology, and a list of some important properties of Banach spaces. (Based on Math Reviews, 1983).

  14. Light Vector Mesons in the Nuclear Medium

    Energy Technology Data Exchange (ETDEWEB)

    Wood, Michael; Nasseripour, Rakhsha; Weygand, Dennis; Djalali, Chaden; Tur, Clarisse; Mosel, Ulrich; Muehlich, Pascal; Adams, Gary; Amaryan, Moscov; Amaryan, Moskov; Ambrozewicz, Pawel; Anghinolfi, Marco; Asryan, Gegham; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Baillie, Nathan; Ball, James; Baltzell, Nathan; Barrow, Steve; Battaglieri, Marco; Bedlinskiy, Ivan; Bektasoglu, Mehmet; Bellis, Matthew; Benmouna, Nawal; Berman, Barry; Biselli, Angela; Blaszczyk, Lukasz; Bouchigny, Sylvain; Boyarinov, Sergey; Bradford, Robert; Branford, Derek; Briscoe, William; Brooks, William; Burkert, Volker; Butuceanu, Cornel; Calarco, John; Careccia, Sharon; Carman, Daniel; Carnahan, Bryan; Casey, Liam; Chen, Shifeng; Cheng, Lu; Cole, Philip; Collins, Patrick; Coltharp, Philip; Crabb, Donald; Crannell, Hall; Crede, Volker; Cummings, John; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Degtiarenko, Pavel; Denizli, Haluk; Dennis, Lawrence; Deur, Alexandre; Dharmawardane, Kahanawita; Dickson, Richard; Dodge, Gail; Doughty, David; Dugger, Michael; Dytman, Steven; Dzyubak, Oleksandr; Egiyan, Hovanes; Egiyan, Kim; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Feldman, Gerald; Feuerbach, Robert; Fradi, Ahmed; Funsten, Herbert; Garcon, Michel; Gavalian, Gagik; Gilfoyle, Gerard; Giovanetti, Kevin; Girod, Francois-Xavier; Goetz, John; Gordon, Christopher; Gothe, Ralf; Griffioen, Keith; Guidal, Michel; Guler, Nevzat; Guo, Lei; Gyurjyan, Vardan; Hadjidakis, Cynthia; Hafidi, Kawtar; Hakobyan, Hayk; Hakobyan, Rafael; Hanretty, Charles; Hardie, John; Hassall, Neil; Hersman, F.; Hicks, Kenneth; Hleiqawi, Ishaq; Holtrop, Maurik; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Ito, Mark; Jenkins, David; Jo, Hyon-Suk; Johnstone, John; Joo, Kyungseon; Juengst, Henry; Kalantarians, Narbe; Kellie, James; Khandaker, Mahbubul; Khetarpal, Puneet; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Klimenko, Alexei; Kossov, Mikhail; Krahn, Zebulun; Kramer, Laird; Kubarovsky, Valery; Kuhn, Joachim; Kuhn, Sebastian; Kuleshov, Sergey; Lachniet, Jeff; Laget, Jean; Langheinrich, Jorn; Lawrence, David; Li, Ji; Livingston, Kenneth; Lu, Haiyun; MacCormick, Marion; Markov, Nikolai; Mattione, Paul; McAleer, Simeon; McKinnon, Bryan; McNabb, John; Mecking, Bernhard; Mehrabyan, Surik; Melone, Joseph; Mestayer, Mac; Meyer, Curtis; Mibe, Tsutomu; Mikhaylov, Konstantin; Minehart, Ralph; Mirazita, Marco; Miskimen, Rory; Mokeev, Viktor; Moriya, Kei; Morrow, Steven; Moteabbed, Maryam; Mueller, James; Munevar Espitia, Edwin; Mutchler, Gordon; Nadel-Turonski, Pawel; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Niczyporuk, Bogdan; Niroula, Megh; Niyazov, Rustam; Nozar, Mina; Osipenko, Mikhail; Ostrovidov, Alexander; Park, Kijun; Pasyuk, Evgueni; Paterson, Craig; Pereira, Sergio; Pierce, Joshua; Pivnyuk, Nikolay; Pocanic, Dinko; Pogorelko, Oleg; Pozdnyakov, Sergey; Preedom, Barry; Price, John; Prok, Yelena; Protopopescu, Dan; Raue, Brian; Riccardi, Gregory; Ricco, Giovanni; Ripani, Marco; Ritchie, Barry; Ronchetti, Federico; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Salamanca, Julian; Salgado, Carlos; Santoro, Joseph; Sapunenko, Vladimir; Schumacher, Reinhard; Serov, Vladimir; Sharabian, Youri; Sharov, Dmitri; Shvedunov, Nikolay; Smith, Elton; Smith, Lee; Sober, Daniel; Sokhan, Daria; Stavinsky, Aleksey; Stepanyan, Stepan; Stepanyan, Samuel; Stokes, Burnham; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tedeschi, David; Tkabladze, Avtandil; Tkachenko, Svyatoslav; Todor, Luminita; Ungaro, Maurizio; Vineyard, Michael; Vlassov, Alexander; Watts, Daniel; Weinstein, Lawrence; Williams, Michael; Wolin, Elliott; Yegneswaran, Amrit; Zana, Lorenzo; Zhang, Bin; Zhang, Jixie; Zhao, Bo; Zhao, Zhiwen

    2008-07-01

    The light vector mesons ($\\rho$, $\\omega$, and $\\phi$) were produced in deuterium, carbon, titanium, and iron targets in a search for possible in-medium modifications to the properties of the $\\rho$ meson at normal nuclear densities and zero temperature. The vector mesons were detected with the CEBAF Large Acceptance Spectrometer (CLAS) via their decays to $e^{+}e^{-}$. The rare leptonic decay was chosen to reduce final-state interactions. A combinatorial background was subtracted from the invariant mass spectra using a well-established event-mixing technique. The $\\rho$ meson mass spectrum was extracted after the $\\omega$ and $\\phi$ signals were removed in a nearly model-independent way. Comparisons were made between the $\\rho$ mass spectra from the heavy targets ($A > 2$) with the mass spectrum extracted from the deuterium target. With respect to the $\\rho$-meson mass, we obtain a small shift compatible with zero. Also, we measure widths consistent with standard nuclear many-body eff

  15. Holographic vector-wave femtosecond laser processing

    Science.gov (United States)

    Hayasaki, Yoshio; Hasegawa, Satoshi

    2016-03-01

    Arbitrary and variable beam shaping of femtosecond pulses by a computer-generated hologram (CGH) displayed on a spatial light modulator (SLM) have been applied to femtosecond laser processing. The holographic femtosecond laser processing has been widely used in many applications such as two-photon polymerization, optical waveguide fabrication, fabrication of volume phase gratings in polymers, and surface nanostructuring. A vector wave that has a spatial distribution of polarization states control of femtosecond pulses gives good performances for the femtosecond laser processing. In this paper, an in- system optimization of a CGH for massively-parallel femtosecond laser processing, a dynamic control of spatial spectral dispersion to improve the focal spot shape, and the holographic vector-wave femtosecond laser processing are demonstrated.

  16. Thrust vector control using electric actuation

    Science.gov (United States)

    Bechtel, Robert T.; Hall, David K.

    1995-01-01

    Presently, gimbaling of launch vehicle engines for thrust vector control is generally accomplished using a hydraulic system. In the case of the space shuttle solid rocket boosters and main engines, these systems are powered by hydrazine auxiliary power units. Use of electromechanical actuators would provide significant advantages in cost and maintenance. However, present energy source technologies such as batteries are heavy to the point of causing significant weight penalties. Utilizing capacitor technology developed by the Auburn University Space Power Institute in collaboration with the Auburn CCDS, Marshall Space Flight Center (MSFC) and Auburn are developing EMA system components with emphasis on high discharge rate energy sources compatible with space shuttle type thrust vector control requirements. Testing has been done at MSFC as part of EMA system tests with loads up to 66000 newtons for pulse times of several seconds. Results show such an approach to be feasible providing a potential for reduced weight and operations costs for new launch vehicles.

  17. Heterotic String Compactification and New Vector Bundles

    Science.gov (United States)

    Lin, Hai; Wu, Baosen; Yau, Shing-Tung

    2016-07-01

    We propose a construction of Kähler and non-Kähler Calabi-Yau manifolds by branched double covers of twistor spaces. In this construction we use the twistor spaces of four-manifolds with self-dual conformal structures, with the examples of connected sum of n {mathbb{P}2}s. We also construct K3-fibered Calabi-Yau manifolds from the branched double covers of the blow-ups of the twistor spaces. These manifolds can be used in heterotic string compactifications to four dimensions. We also construct stable and polystable vector bundles. Some classes of these vector bundles can give rise to supersymmetric grand unified models with three generations of quarks and leptons in four dimensions.

  18. Performance of a vector velocity estimator

    DEFF Research Database (Denmark)

    Munk, Peter; Jensen, Jørgen Arendt

    1998-01-01

    It is a well-known limitation of all commercially available scanners that only the velocity component along the propagation direction of the emitted pulse is measured, when evaluating blood velocities with ultrasound. Proposals for solving this limitation using several transducers or speckle...... tracking can be found in the literature, but no method with a satisfactory performance has been found that can be used in a commercial implementation. A method for estimation of the velocity vector is presented. Here an oscillation transverse to the ultrasound beam is generated, so that a transverse motion...... in an autocorrelation approach that yields both the axial and the lateral velocity, and thus the velocity vector. The method has the advantage that a standard array transducer and a modified digital beamformer, like those used in modern ultrasound scanners, is sufficient to obtain the information needed. The signal...

  19. MAGSAT: Vector magnetometer absolute sensor alignment determination

    Science.gov (United States)

    Acuna, M. H.

    1981-01-01

    A procedure is described for accurately determining the absolute alignment of the magnetic axes of a triaxial magnetometer sensor with respect to an external, fixed, reference coordinate system. The method does not require that the magnetic field vector orientation, as generated by a triaxial calibration coil system, be known to better than a few degrees from its true position, and minimizes the number of positions through which a sensor assembly must be rotated to obtain a solution. Computer simulations show that accuracies of better than 0.4 seconds of arc can be achieved under typical test conditions associated with existing magnetic test facilities. The basic approach is similar in nature to that presented by McPherron and Snare (1978) except that only three sensor positions are required and the system of equations to be solved is considerably simplified. Applications of the method to the case of the MAGSAT Vector Magnetometer are presented and the problems encountered discussed.

  20. All-Optical Vector Atomic Magnetometer

    Science.gov (United States)

    Patton, B.; Zhivun, E.; Hovde, D. C.; Budker, D.

    2014-07-01

    We demonstrate an all-optical magnetometer capable of measuring the magnitude and direction of a magnetic field using nonlinear magneto-optical rotation in cesium vapor. Vector capability is added by effective modulation of the field along orthogonal axes and subsequent demodulation of the magnetic-resonance frequency. This modulation is provided by the ac Stark shift induced by circularly polarized laser beams. The sensor exhibits a demonstrated rms noise floor of ˜65 fT/√Hz in measurement of the field magnitude and 0.5 mrad /√Hz in the field direction; elimination of technical noise would improve these sensitivities to 12 fT /√Hz and 10 μrad /√Hz , respectively. Applications for this all-optical vector magnetometer would include magnetically sensitive fundamental physics experiments, such as the search for a permanent electric dipole moment of the neutron.

  1. Higgsed Stueckelberg vector and Higgs quadratic divergence

    Directory of Open Access Journals (Sweden)

    Durmuş Ali Demir

    2015-01-01

    Full Text Available Here we show that, a hidden vector field whose gauge invariance is ensured by a Stueckelberg scalar and whose mass is spontaneously generated by the Standard Model Higgs field contributes to quadratic divergences in the Higgs boson mass squared, and even leads to its cancellation at one-loop when Higgs coupling to gauge field is fine-tuned. In contrast to mechanisms based on hidden scalars where a complete cancellation cannot be achieved, stabilization here is complete in that the hidden vector and the accompanying Stueckelberg scalar are both free from quadratic divergences at one-loop. This stability, deriving from hidden exact gauge invariance, can have important implications for modeling dark phenomena like dark matter, dark energy, dark photon and neutrino masses. The hidden fields can be produced at the LHC.

  2. Generalized Toeplitz operators and cyclic vectors

    CERN Document Server

    Gassier, G; Zerouali, E H

    2003-01-01

    We give in this paper some asymptotic Von Neumann inequalities for power bounded operators in the class C subrho intersection C sub 1. and some spacial von Neumann inequalities associated with non zero elements of the point spectrum, when it is non void, of generalized Toeplitz operators. Introducing perturbed kernel, we consider classes C sub R which extend the classical classes C subrho. We give results about absolute continuity with respect to the Haar measure for operators in class C sub R intersection C sub 1. This allows us to give new results on cyclic vectors for such operators and provides invariant subspaces for their powers. Relationships between cyclic vectors for T and T* involving generalized Toeplitz operators are given and the commutativity of left brace T right brace', the commutant of T is discussed.

  3. Online support vector regression for reinforcement learning

    Institute of Scientific and Technical Information of China (English)

    Yu Zhenhua; Cai Yuanli

    2007-01-01

    The goal in reinforcement learning is to learn the value of state-action pair in order to maximize the total reward. For continuous states and actions in the real world, the representation of value functions is critical. Furthermore, the samples in value functions are sequentially obtained. Therefore, an online support vector regression (OSVR) is set up, which is a function approximator to estimate value functions in reinforcement learning. OSVR updates the regression function by analyzing the possible variation of support vector sets after new samples are inserted to the training set. To evaluate the OSVR learning ability, it is applied to the mountain-car task. The simulation results indicate that the OSVR has a preferable convergence speed and can solve continuous problems that are infeasible using lookup table.

  4. Lepton flavor violation with light vector bosons

    CERN Document Server

    Heeck, Julian

    2016-01-01

    New sub-GeV vector bosons with couplings to muons but not electrons have been discussed in order to explain the muon's magnetic moment, the gap of high-energy neutrinos in IceCube or the proton radius puzzle. If such a light Z' not only violates lepton universality but also lepton flavor, as expected for example from the recent hint for $h\\to\\mu\\tau$ at CMS, the two-body decay mode $\\tau \\to \\mu Z'$ opens up and for $M_{Z'} < 2 m_\\mu$ gives better constraints than $\\tau\\to 3\\mu$ already with 20-year-old ARGUS limits. We discuss the general prospects and motivation of light vector bosons with lepton-flavor-violating couplings.

  5. Relativistic Thermodynamics: A Modern 4-Vector Approach

    Directory of Open Access Journals (Sweden)

    J. Güémez

    2011-01-01

    Full Text Available Using the Minkowski relativistic 4-vector formalism, based on Einstein's equation, and the relativistic thermodynamics asynchronous formulation (Grøn (1973, the isothermal compression of an ideal gas is analyzed, considering an electromagnetic origin for forces applied to it. This treatment is similar to the description previously developed by Van Kampen (van Kampen (1969 and Hamity (Hamity (1969. In this relativistic framework Mechanics and Thermodynamics merge in the first law of relativistic thermodynamics expressed, using 4-vector notation, such as ΔUμ  =  Wμ  +  Qμ, in Lorentz covariant formulation, which, with the covariant formalism for electromagnetic forces, constitutes a complete Lorentz covariant formulation for classical physics.

  6. Intraoperative Vector Flow Imaging of the Heart

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Møller-Sørensen, Hasse; Pedersen, Mads Møller;

    2013-01-01

    patients. Antegrade central jet and retrograde flow near the vessel wall in the ascending aorta and the pulmonary artery were seen during systole, while stable vortices were seen in the aortic sinuses and complex flow patterns were seen around the valves during diastole. In the right atrium, a stable......The cardiac flow is complex and multidirectional, and difficult to measure with conventional Doppler ultrasound (US) methods due to the one-dimensional and angle-dependent velocity estimation. The vector velocity method Transverse Oscillation (TO) has been proposed as a solution to this....... TO is implemented on a conventional US scanner (Pro Focus 2202 UltraView, BK Medical) using a linear transducer (8670, BK Medical) and can provide real-time, angle-independent vector velocity estimates of the cardiac blood flow. During cardiac surgery, epicardiac US examinations using TO were performed on three...

  7. Vector Potential Quantization and the Quantum Vacuum

    Directory of Open Access Journals (Sweden)

    Constantin Meis

    2014-01-01

    Full Text Available We investigate the quantization of the vector potential amplitude of the electromagnetic field to a single photon state starting from the fundamental link equations between the classical electromagnetic theory and the quantum mechanical expressions. The resulting wave-particle formalism ensures a coherent transition between the classical electromagnetic wave theory and the quantum representation. A quantization constant of the photon vector potential is defined. A new quantum vacuum description results directly in having very low energy density. The calculated spontaneous emission rate and Lambs shift for the nS states of the hydrogen atom are in agreement with quantum electrodynamics. This low energy quantum vacuum state might be compatible with recent astrophysical observations.

  8. Support vector machine for automatic pain recognition

    Science.gov (United States)

    Monwar, Md Maruf; Rezaei, Siamak

    2009-02-01

    Facial expressions are a key index of emotion and the interpretation of such expressions of emotion is critical to everyday social functioning. In this paper, we present an efficient video analysis technique for recognition of a specific expression, pain, from human faces. We employ an automatic face detector which detects face from the stored video frame using skin color modeling technique. For pain recognition, location and shape features of the detected faces are computed. These features are then used as inputs to a support vector machine (SVM) for classification. We compare the results with neural network based and eigenimage based automatic pain recognition systems. The experiment results indicate that using support vector machine as classifier can certainly improve the performance of automatic pain recognition system.

  9. Exclusive vector meson production at HERMES

    Directory of Open Access Journals (Sweden)

    Movsisyan Aram

    2014-06-01

    Full Text Available Exclusive electroproduction of vector mesons has been measured on hydrogen and deuterium targets at HERMES using the 27.6 GeV electron/positron beam of HERA. From this process, more information can be obtained about generalized parton distributions (GPDs, which provide a unified description of the structure of hadrons embedding longitudinal-momentum distributions (ordinary PDFs and transverse-position information (form factors. The study of the azimuthal distribution of the decay products via spin-density matrix elements provide constraints on helicity-amplitudes used to describe exclusive vector-meson production. Recent results from the HERMES experiment on the production of rho, omega and phi mesons will be presented.

  10. Exclusive vector meson production at HERMES

    Science.gov (United States)

    Movsisyan, Aram

    2014-06-01

    Exclusive electroproduction of vector mesons has been measured on hydrogen and deuterium targets at HERMES using the 27.6 GeV electron/positron beam of HERA. From this process, more information can be obtained about generalized parton distributions (GPDs), which provide a unified description of the structure of hadrons embedding longitudinal-momentum distributions (ordinary PDFs) and transverse-position information (form factors). The study of the azimuthal distribution of the decay products via spin-density matrix elements provide constraints on helicity-amplitudes used to describe exclusive vector-meson production. Recent results from the HERMES experiment on the production of rho, omega and phi mesons will be presented.

  11. Experimental generation of amplitude squeezed vector beams

    CERN Document Server

    Chille, Vanessa; Semmler, Marion; Banzer, Peter; Aiello, Andrea; Leuchs, Gerd; Marquardt, Christoph

    2016-01-01

    We present an experimental method for the generation of amplitude squeezed high-order vector beams. The light is modified twice by a spatial light modulator such that the vector beam is created by means of a collinear interferometric technique. A major advantage of this approach is that it avoids systematic losses, which are detrimental as they cause decoherence in continuous-variable quantum systems. The utilisation of a spatial light modulator (SLM) gives the flexibility to switch between arbitrary mode orders. The conversion efficiency with our setup is only limited by the efficiency of the SLM. We show the experimental generation of Laguerre-Gauss (LG) modes with radial indices up to 1 and azimuthal indices up to 3 with complex polarization structures and a quantum noise reduction up to -0.9dB$\\pm$0.1dB. The corresponding polarization structures are studied in detail by measuring the spatial distribution of the Stokes parameters.

  12. Bloch vector, disclination and exotic quantum holonomy

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Atushi, E-mail: tanaka-atushi@tmu.ac.jp [Department of Physics, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397 (Japan); Cheon, Taksu [Laboratory of Physics, Kochi University of Technology, Tosa Yamada, Kochi 782-8502 (Japan)

    2015-09-04

    A topological formulation of the eigenspace anholonomy, where eigenspaces are interchanged by adiabatic cycles, is introduced. The anholonomy in two-level systems is identified with a disclination of the director (headless vector) of a Bloch vector, which characterizes eigenprojectors. The covering map structure behind the exotic quantum holonomy and the role of the homotopy classification of adiabatic cycles are elucidated. The extensions of this formulation to nonadiabatic cycles and N-level systems are outlined. - Highlights: • A topological formulation of the eigenspace anholonomy is proposed. • The covering map structure behind the anholonomy is identified. • The role of homotopy classification of adiabatic cycles is explained. • The anholonomy in two-level systems is associated with disclinations. • The present formulation offers an extension to nonadiabatic cycles.

  13. Fractional vector calculus and fractional Maxwell's equations

    International Nuclear Information System (INIS)

    The theory of derivatives and integrals of non-integer order goes back to Leibniz, Liouville, Grunwald, Letnikov and Riemann. The history of fractional vector calculus (FVC) has only 10 years. The main approaches to formulate a FVC, which are used in the physics during the past few years, will be briefly described in this paper. We solve some problems of consistent formulations of FVC by using a fractional generalization of the Fundamental Theorem of Calculus. We define the differential and integral vector operations. The fractional Green's, Stokes' and Gauss's theorems are formulated. The proofs of these theorems are realized for simplest regions. A fractional generalization of exterior differential calculus of differential forms is discussed. Fractional nonlocal Maxwell's equations and the corresponding fractional wave equations are considered

  14. Meromorphic Vector Fields and Circle Packings

    DEFF Research Database (Denmark)

    Dias, Kealey

    of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions or meromorphic (allowing poles...... to the development of a theory of discrete analytic functions, which is a new tool in conformal geometry that can be used to implement many of the classical tools from complex analysis. Circle packing is a relatively new subject that has a great potential for technological applications, specifically for imaging......The objective of the Ph.D. project is to initiate a classification of bifurcations of meromorphic vector fields and to clarify their relation to circle packings. Technological applications are to image analysis and to effective grid generation using discrete conformal mappings. The two branches...

  15. Improving the lattice axial vector current

    CERN Document Server

    Horsley, R; Perlt, H; Rakow, P E L; Schierholz, G; Schiller, A; Zanotti, J M

    2015-01-01

    For Wilson and clover fermions traditional formulations of the axial vector current do not respect the continuum Ward identity which relates the divergence of that current to the pseudoscalar density. Here we propose to use a point-split or one-link axial vector current whose divergence exactly satisfies a lattice Ward identity, involving the pseudoscalar density and a number of irrelevant operators. We check in one-loop lattice perturbation theory with SLiNC fermion and gauge plaquette action that this is indeed the case including order $O(a)$ effects. Including these operators the axial Ward identity remains renormalisation invariant. First preliminary results of a nonperturbative check of the Ward identity are also presented.

  16. Mono Vector-Quark Production at the LHC

    OpenAIRE

    Cai, Haiying

    2012-01-01

    Vector-like quark is a common feature in many new physics models. We study the vector-like quark production as an s-channel resonance at the Large Hadron Collider for the vector-like quarks mainly mixing with the top- and bottom-quark in the Standard Model. We emphasize that the leptonic angular distribution can be used to discriminate various vector-like quark models.

  17. Development and Applications of VSV Vectors Based on Cell Tropism

    OpenAIRE

    HidekiTani; YoshiharuMatsuura

    2012-01-01

    Viral vectors have been available in various fields such as medical and biological research or gene therapy applications. Targeting vectors pseudotyped with distinct viral envelope proteins that influence cell tropism and transfection efficiency is a useful tool not only for examining entry mechanisms or cell tropisms but also for vaccine vector development. Vesicular stomatitis virus (VSV) is an excellent candidate for development as a pseudotype vector. A recombinant VSV lacking its own env...

  18. Private Quantum Channels, Conditional Expectations, and Trace Vectors

    OpenAIRE

    Church, Amber; Kribs, David W.; Pereira, Rajesh; Plosker, Sarah

    2012-01-01

    Private quantum channels are the quantum analogue of the classical one-time pad. Conditional expectations and trace vectors are notions that have been part of operator algebra theory for several decades. We show that the theory of conditional expectations and trace vectors is intimately related to that of private quantum channels. Specifically we give a new geometric characterization of single qubit private quantum channels that relies on trace vectors. We further show that trace vectors comp...

  19. Document Classification Using Support Vector Machine

    OpenAIRE

    Shweta Mayor; Bhasker Pant

    2012-01-01

    Information like NEWS FEEDS is generally stored in the form of documents and files created on the basis of daily occurrence in the world. Classifying an unstructured text in these large document corpora has become cumbersome. Efficiently and effectively retrieving and categorizing these document is a hard task to perform. This research paper discuss in detail the implementation of Support Vector Machine (SVM) for calculating term frequency of the features used as Sports, Business and Entertai...

  20. Nomograms for Visualizing Support Vector Machines

    OpenAIRE

    Zupan, Dejan; Saje, Miran; Jakulin, Aleks; Možina, Martin; Demšar, Janez; Bratko, Ivan; Zupan, Blaz

    2015-01-01

    We propose a simple yet potentially very effective way of visualizing trained support vector machines. Nomograms are an established model visualization technique that can graphically encode the complete model on a single page. The dimensionality of the visualization does not depend on the number of attributes, but merely on the properties of the kernel. To represent the effect of each predictive feature on the log odds ratio scale as required for the nomograms, we employ logistic regression t...

  1. Nomograms for Visualizing Support Vector Machines

    OpenAIRE

    Jakulin, Aleks; Možina, Martin; Demšar, Janez; Bratko, Ivan; Zupan, Blaz

    2005-01-01

    We propose a simple yet potentially very effective way of visualizing trained support vector machines. Nomograms are an established model visualization technique that can graphically encode the complete model on a single page. The dimensionality of the visualization does not depend on the number of attributes, but merely on the properties of the kernel. To represent the effect of each predictive feature on the log odds ratio scale as required for the nomograms, we employ logistic regression t...

  2. Building Program Vector Representations for Deep Learning

    OpenAIRE

    Mou, Lili; Li, Ge; Liu, Yuxuan; Peng, Hao; Jin, Zhi; Xu, Yan; Zhang, Lu

    2014-01-01

    Deep learning has made significant breakthroughs in various fields of artificial intelligence. Advantages of deep learning include the ability to capture highly complicated features, weak involvement of human engineering, etc. However, it is still virtually impossible to use deep learning to analyze programs since deep architectures cannot be trained effectively with pure back propagation. In this pioneering paper, we propose the "coding criterion" to build program vector representations, whi...

  3. Approximating viability kernels with support vector machines

    OpenAIRE

    Deffuant, G.; Chapel, L.; Martin, S.

    2007-01-01

    We propose an algorithm which performs a progressive approximation of a viability kernel, iteratively using a classification method. We establish the mathematical conditions that the classification method should fulfill to guarantee the convergence to the actual viability kernel. We study more particularly the use of support vector machines (SVMs) as classification techniques. We show that they make possible to use gradient optimisation techniques to find a viable control at each time step, a...

  4. Agriculture Canada Central Saskatchewan Vector Soils Data

    Science.gov (United States)

    Knapp, David; Hall, Forrest G. (Editor); Rostad, Harold

    2000-01-01

    This data set consists of GIS layers that describe the soils of the BOREAS SSA. These original data layers were submitted as vector data in ARC/INFO EXPORT format. These data also include the soil name and soil layer files, which provide additional information about the soils. There are three sets of attributes that include information on the primary, secondary, and tertiary soil type within each polygon. Thus, there is a total of nine main attributes in this data set.

  5. A vector space approach to geometry

    CERN Document Server

    Hausner, Melvin

    2010-01-01

    The effects of geometry and linear algebra on each other receive close attention in this examination of geometry's correlation with other branches of math and science. In-depth discussions include a review of systematic geometric motivations in vector space theory and matrix theory; the use of the center of mass in geometry, with an introduction to barycentric coordinates; axiomatic development of determinants in a chapter dealing with area and volume; and a careful consideration of the particle problem. 1965 edition.

  6. Adenoviral Vectors for Hemophilia Gene Therapy

    Science.gov (United States)

    Brunetti-Pierri, N; Ng, Philip

    2013-01-01

    Hemophilia is an inherited blood clotting disorder resulting from deficiency of blood coagulation factors. Current standard of care for hemophilia patients is frequent intravenous infusions of the missing coagulation factor. Gene therapy for hemophilia involves the introduction of a normal copy of the deficient coagulation factor gene thereby potentially offering a definitive cure for the bleeding disorder. A variety of approaches have been pursued for hemophilia gene therapy and this review article focuses on those that use adenoviral vectors. PMID:24883229

  7. Stacked Quantizers for Compositional Vector Compression

    OpenAIRE

    Martinez, Julieta; Hoos, Holger H; Little, James J.

    2014-01-01

    Recently, Babenko and Lempitsky introduced Additive Quantization (AQ), a generalization of Product Quantization (PQ) where a non-independent set of codebooks is used to compress vectors into small binary codes. Unfortunately, under this scheme encoding cannot be done independently in each codebook, and optimal encoding is an NP-hard problem. In this paper, we observe that PQ and AQ are both compositional quantizers that lie on the extremes of the codebook dependence-independence assumption, a...

  8. Droogboeketten als vector voor exoten (Diptera: Tephritidae)?

    OpenAIRE

    Smit, J.T.

    2006-01-01

    Everlasting flowers as a vector for exotic insects (Diptera: Tephritidae)? In this paper two rearing occasions of exotic fruit fly species of the genus Terellia are documented. Terellia fuscicornis (Loew, 1844) was reared from a ‘tropical’ plant (probably a thistle species) of unknown origin. Terellia longicauda (Meigen, 1830) was reared from Cirsium rivulare from southern France. On both occasions the plants were left to dry to serve as everlasting flowers. The differences between these exot...

  9. Random Projections for Linear Support Vector Machines

    OpenAIRE

    Paul, Saurabh; Boutsidis, Christos; Magdon-Ismail, Malik; Drineas, Petros

    2012-01-01

    Let X be a data matrix of rank \\rho, whose rows represent n points in d-dimensional space. The linear support vector machine constructs a hyperplane separator that maximizes the 1-norm soft margin. We develop a new oblivious dimension reduction technique which is precomputed and can be applied to any input matrix X. We prove that, with high probability, the margin and minimum enclosing ball in the feature space are preserved to within \\epsilon-relative error, ensuring comparable generalizatio...

  10. Independence Test for High Dimensional Random Vectors

    OpenAIRE

    Pan, G.; Gao, J.; Yang, Y.; Guo, M.

    2012-01-01

    This paper proposes a new mutual independence test for a large number of high dimensional random vectors. The test statistic is based on the characteristic function of the empirical spectral distribution of the sample covariance matrix. The asymptotic distributions of the test statistic under the null and local alternative hypotheses are established as dimensionality and the sample size of the data are comparable. We apply this test to examine multiple MA(1) and AR(1) models, panel data model...

  11. Universal learning curves of support vector machines

    OpenAIRE

    Opper, Manfred; Urbanczik, Robert

    2001-01-01

    Using methods of Statistical Physics, we investigate the role of model complexity in learning with support vector machines (SVMs), which are an important alternative to neural networks. We show the advantages of using SVMs with kernels of infinite complexity on noisy target rules, which, in contrast to common theoretical beliefs, are found to achieve optimal generalization error although the training error does not converge to the generalization error. Moreover, we find a universal asymptotic...

  12. Anisotropic cosmological solutions in massive vector theories

    OpenAIRE

    Heisenberg, Lavinia; Kase, Ryotaro; Tsujikawa, Shinji

    2016-01-01

    In beyond-generalized Proca theories including the extension to theories higher than second order, we study the role of a spatial component $v$ of a massive vector field on the anisotropic cosmological background. We show that, as in the case of the isotropic cosmological background, there is no additional ghostly degrees of freedom associated with the Ostrogradski instability. In second-order generalized Proca theories we find the existence of anisotropic solutions on which the ratio between...

  13. Image indexing based on vector quantization

    Science.gov (United States)

    Grana Romay, Manuel; Rebollo, Israel

    2000-10-01

    We propose the computation of the color palette of each image in isolation, using Vector Quantization methods. The image features are, then, the color palette and the histogram of the color quantization of the image with this color palette. We propose as a measure of similitude the weighted sum of the differences between the color palettes and the corresponding histograms. This approach allows the increase of the database without the recomputation of the image features and without substantial loss of discriminative power.

  14. Vector-tensor interaction of gravitation

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yuan-zhong; Guo han-ying

    1982-11-01

    In the paper, by using the equation of motion a particle, we show that the antigravity exist in the vector-tensor model of gravitation. Thus the motion of a particle deviates from the geodesic equation. In Newtonian approximation and weak gravitational field, acceleration of a particle in a spherically symmetric and astatic gravitation field is zero. The result is obviously not in agreement with gravitational phenomena.

  15. Complete algebraic vector fields on affine surfaces

    OpenAIRE

    Kaliman, Shulim; Kutzschebauch, Frank; Leuenberger, Matthias

    2014-01-01

    Let $\\AAutH (X)$ be the subgroup of the group $\\AutH (X)$ of holomorphic automorphisms of a normal affine algebraic surface $X$ generated by elements of flows associated with complete algebraic vector fields. Our main result is a classification of all normal affine algebraic surfaces $X$ quasi-homogeneous under $\\AAutH (X)$ in terms of the dual graphs of the boundaries $\\bX \\setminus X$ of their SNC-completions $\\bX$.

  16. Image Segmentation Based on Support Vector Machine

    Institute of Scientific and Technical Information of China (English)

    XU Hai-xiang; ZHU Guang-xi; TIAN Jin-wen; ZHANG Xiang; PENG Fu-yuan

    2005-01-01

    Image segmentation is a necessary step in image analysis. Support vector machine (SVM) approach is proposed to segment images and its segmentation performance is evaluated.Experimental results show that: the effects of kernel function and model parameters on the segmentation performance are significant; SVM approach is less sensitive to noise in image segmentation; The segmentation performance of SVM approach is better than that of back-propagation multi-layer perceptron (BP-MLP) approach and fuzzy c-means (FCM) approach.

  17. Multi-Vector Portable Intrusion Detection System

    OpenAIRE

    Moyers, Benjamin

    2009-01-01

    This research describes an intrusion detection system designed to fulfill the need for increased mobile device security. The Battery-Sensing Intrusion Protection System (B-SIPS) [1] initially took a non-conventional approach to intrusion detection by recognizing attacks based on anomalous Instantaneous Current (IC) drainage. An extension of B-SIPS, the Multi-Vector Portable Intrusion Detection System (MVP-IDS) validates the idea of recognizing attacks based on anomalous IC drain by correlat...

  18. The evolution of heart gene delivery vectors

    OpenAIRE

    Wasala, Nalinda B.; Shin, Jin-Hong; Duan, Dongsheng

    2011-01-01

    Gene therapy holds promise for treating numerous heart diseases. A key premise for the success of cardiac gene therapy is the development of powerful gene transfer vehicles that can achieve highly efficient and persistent gene transfer specifically in the heart. Other features of an ideal vector include negligible toxicity, minimal immunogenicity and easy manufacturing. Rapid progress in the fields of molecular biology and virology has offered great opportunities to engineer various genetic m...

  19. Fractional Vector Calculus and Fractional Maxwell's Equations

    OpenAIRE

    Vasily E. Tarasov

    2009-01-01

    The theory of derivatives and integrals of non-integer order goes back to Leibniz, Liouville, Grunwald, Letnikov and Riemann. The history of fractional vector calculus (FVC) has only 10 years. The main approaches to formulate a FVC, which are used in the physics during the past few years, will be briefly described in this paper. We solve some problems of consistent formulations of FVC by using a fractional generalization of the Fundamental Theorem of Calculus. We define the differential and i...

  20. Relativistic Thermodynamics: A Modern 4-Vector Approach

    OpenAIRE

    J. Güémez

    2011-01-01

    Using the Minkowski relativistic 4-vector formalism, based on Einstein's equation, and the relativistic thermodynamics asynchronous formulation (Grøn (1973)), the isothermal compression of an ideal gas is analyzed, considering an electromagnetic origin for forces applied to it. This treatment is similar to the description previously developed by Van Kampen (van Kampen (1969)) and Hamity (Hamity (1969)). In this relativistic framework Mechanics and Thermodynamics merge in the first law of rela...

  1. Multifractal vector fields and stochastic Clifford algebra.

    Science.gov (United States)

    Schertzer, Daniel; Tchiguirinskaia, Ioulia

    2015-12-01

    In the mid 1980s, the development of multifractal concepts and techniques was an important breakthrough for complex system analysis and simulation, in particular, in turbulence and hydrology. Multifractals indeed aimed to track and simulate the scaling singularities of the underlying equations instead of relying on numerical, scale truncated simulations or on simplified conceptual models. However, this development has been rather limited to deal with scalar fields, whereas most of the fields of interest are vector-valued or even manifold-valued. We show in this paper that the combination of stable Lévy processes with Clifford algebra is a good candidate to bridge up the present gap between theory and applications. We show that it indeed defines a convenient framework to generate multifractal vector fields, possibly multifractal manifold-valued fields, based on a few fundamental and complementary properties of Lévy processes and Clifford algebra. In particular, the vector structure of these algebra is much more tractable than the manifold structure of symmetry groups while the Lévy stability grants a given statistical universality.

  2. Multifractal vector fields and stochastic Clifford algebra.

    Science.gov (United States)

    Schertzer, Daniel; Tchiguirinskaia, Ioulia

    2015-12-01

    In the mid 1980s, the development of multifractal concepts and techniques was an important breakthrough for complex system analysis and simulation, in particular, in turbulence and hydrology. Multifractals indeed aimed to track and simulate the scaling singularities of the underlying equations instead of relying on numerical, scale truncated simulations or on simplified conceptual models. However, this development has been rather limited to deal with scalar fields, whereas most of the fields of interest are vector-valued or even manifold-valued. We show in this paper that the combination of stable Lévy processes with Clifford algebra is a good candidate to bridge up the present gap between theory and applications. We show that it indeed defines a convenient framework to generate multifractal vector fields, possibly multifractal manifold-valued fields, based on a few fundamental and complementary properties of Lévy processes and Clifford algebra. In particular, the vector structure of these algebra is much more tractable than the manifold structure of symmetry groups while the Lévy stability grants a given statistical universality. PMID:26723166

  3. Pattern vectors from algebraic graph theory.

    Science.gov (United States)

    Wilson, Richard C; Hancock, Edwin R; Luo, Bin

    2005-07-01

    Graph structures have proven computationally cumbersome for pattern analysis. The reason for this is that, before graphs can be converted to pattern vectors, correspondences must be established between the nodes of structures which are potentially of different size. To overcome this problem, in this paper, we turn to the spectral decomposition of the Laplacian matrix. We show how the elements of the spectral matrix for the Laplacian can be used to construct symmetric polynomials that are permutation invariants. The coefficients of these polynomials can be used as graph features which can be encoded in a vectorial manner. We extend this representation to graphs in which there are unary attributes on the nodes and binary attributes on the edges by using the spectral decomposition of a Hermitian property matrix that can be viewed as a complex analogue of the Laplacian. To embed the graphs in a pattern space, we explore whether the vectors of invariants can be embedded in a low-dimensional space using a number of alternative strategies, including principal components analysis (PCA), multidimensional scaling (MDS), and locality preserving projection (LPP). Experimentally, we demonstrate that the embeddings result in well-defined graph clusters. Our experiments with the spectral representation involve both synthetic and real-world data. The experiments with synthetic data demonstrate that the distances between spectral feature vectors can be used to discriminate between graphs on the basis of their structure. The real-world experiments show that the method can be used to locate clusters of graphs. PMID:16013758

  4. ATLAS measurements of vector boson production

    CERN Document Server

    Debenedetti, Chiara; The ATLAS collaboration

    2016-01-01

    Vector boson production in pp collisions at 7, 8 and 13 TeV has been extensively studied by ATLAS. Recent results include the precision measurements of the transverse momentum of the Z/gamma* boson production, sensitive to soft resummation effects, hard jet emissions and electroweak corrections. A precise measurement of the angular coefficients of the Z­boson production tests the underlying QCD dynamics of the Drell­Yan process. A first measurement of the inclusive W and Z cross section at a cms energy of 13TeV has been derived. The Production of jets in association with a vector boson is an important process to study QCD in a multi­scale environment. Cross sections, differential in several kinematics variables, have been measured with the ATLAS detector and compared to state­of­the­art QCD calculations and Monte Carlo simulations. First measurements of vector boson + jets production have been performed at cms energies of 13TeV. An overview of these results is given.

  5. Anisotropic cosmological solutions in massive vector theories

    CERN Document Server

    Heisenberg, Lavinia; Tsujikawa, Shinji

    2016-01-01

    In beyond-generalized Proca theories including the extension to theories higher than second order, we study the role of a spatial component $v$ of a massive vector field on the anisotropic cosmological background. We show that, as in the case of the isotropic cosmological background, there is no additional ghostly degrees of freedom associated with the Ostrogradski instability. In second-order generalized Proca theories we find the existence of anisotropic solutions on which the ratio between the anisotropic expansion rate $\\Sigma$ and the isotropic expansion rate $H$ remains nearly constant in the radiation-dominated epoch. In the regime where $\\Sigma/H$ is constant, the spatial vector component $v$ works as a dark radiation with the equation of state close to $1/3$. During the matter era, the ratio $\\Sigma/H$ decreases with the decrease of $v$. As long as the conditions $|\\Sigma| \\ll H$ and $v^2 \\ll \\phi^2$ are satisfied around the onset of late-time cosmic acceleration, where $\\phi$ is the temporal vector ...

  6. Multifractal vector fields and stochastic Clifford algebra

    Energy Technology Data Exchange (ETDEWEB)

    Schertzer, Daniel, E-mail: Daniel.Schertzer@enpc.fr; Tchiguirinskaia, Ioulia, E-mail: Ioulia.Tchiguirinskaia@enpc.fr [University Paris-Est, Ecole des Ponts ParisTech, Hydrology Meteorology and Complexity HM& Co, Marne-la-Vallée (France)

    2015-12-15

    In the mid 1980s, the development of multifractal concepts and techniques was an important breakthrough for complex system analysis and simulation, in particular, in turbulence and hydrology. Multifractals indeed aimed to track and simulate the scaling singularities of the underlying equations instead of relying on numerical, scale truncated simulations or on simplified conceptual models. However, this development has been rather limited to deal with scalar fields, whereas most of the fields of interest are vector-valued or even manifold-valued. We show in this paper that the combination of stable Lévy processes with Clifford algebra is a good candidate to bridge up the present gap between theory and applications. We show that it indeed defines a convenient framework to generate multifractal vector fields, possibly multifractal manifold-valued fields, based on a few fundamental and complementary properties of Lévy processes and Clifford algebra. In particular, the vector structure of these algebra is much more tractable than the manifold structure of symmetry groups while the Lévy stability grants a given statistical universality.

  7. Lorentz-invariant ensembles of vector backgrounds

    International Nuclear Information System (INIS)

    We consider gauge field theories in the presence of ensembles of vector backgrounds. While Lorentz invariance is explicitly broken in the presence of any single background, here, the Lorentz invariance of the theory is restored by averaging over a Lorentz-invariant ensemble of backgrounds, i.e., a set of background vectors that is mapped onto itself under Lorentz transformations. This framework is used to study the effects of a non-trivial but Lorentz-invariant vacuum structure or mass dimension two vector condensates by identifying the background with a shift of the gauge field. Up to now, the ensembles used in the literature comprise configurations corresponding to non-zero field tensors together with such with vanishing field strength. We find that even when constraining the ensembles to pure gauge configurations, the usual high-energy degrees of freedom are removed from the spectrum of asymptotic states in the presence of said backgrounds in Euclidean and in Minkowski space. We establish this result not only for the propagators to all orders in the background and otherwise at tree level but for the full propagator

  8. Scaffolding Vector Representations for Student Learning inside a Physics Game

    Science.gov (United States)

    D'Angelo Cynthia

    2010-01-01

    Vectors and vector addition are difficult concepts for many introductory physics students and traditional instruction does not usually sufficiently address these difficulties. Vectors play a major role in most topics in introductory physics and without a complete understanding of them many students are unable to make sense of the physics topics…

  9. Killing Vector Fields of Standard Static Space-times

    OpenAIRE

    Dobarro, Fernando; Unal, Bulent

    2008-01-01

    We consider Killing vector fields on standard static space-times and obtain equations for a vector field on a standard static space-time to be Killing. We also provide a characterization of Killing vector fields on standard static space-times with compact Riemannian parts.

  10. Learning Vector Coding Methods of ART1 and Their Applications

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    As one of the unsupervised learning models, ART1 has been widely used in data mining or other fields, while coding of it's learning vector is very important. Their input vector coding methods and learning vector coding methods are described in detail. The corresponding applications are given.

  11. 42 CFR 71.54 - Etiological agents, hosts, and vectors.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Etiological agents, hosts, and vectors. 71.54..., INSPECTION, LICENSING FOREIGN QUARANTINE Importations § 71.54 Etiological agents, hosts, and vectors. (a) A... any arthropod or other animal host or vector of human disease, or any exotic living arthropod or...

  12. 40 CFR 258.22 - Disease vector control.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Disease vector control. 258.22 Section... MUNICIPAL SOLID WASTE LANDFILLS Operating Criteria § 258.22 Disease vector control. (a) Owners or operators of all MSWLF units must prevent or control on-site populations of disease vectors using...

  13. Environmental statistical modelling of mosquito vectors at different geographical scales

    NARCIS (Netherlands)

    Cianci, D.

    2015-01-01

    Vector-borne diseases are infections transmitted by the bite of infected arthropod vectors, such as mosquitoes, ticks, fleas, midges and flies. Vector-borne diseases pose an increasingly wider threat to global public health, both in terms of people affected and their geographical spread. Mosquitoes

  14. A note on Finsler spaces admitting parallel vector fields

    International Nuclear Information System (INIS)

    In this note by considering a special vector field, we study the consequences of the definition of parallel vector fields in a Finsler space given by Singh. An alternative definition for the parallelism of a vector field in a Finsler space is suggested and some properties studied. (author)

  15. Large Animal Models for Foamy Virus Vector Gene Therapy

    Directory of Open Access Journals (Sweden)

    Peter A. Horn

    2012-12-01

    Full Text Available Foamy virus (FV vectors have shown great promise for hematopoietic stem cell (HSC gene therapy. Their ability to efficiently deliver transgenes to multi-lineage long-term repopulating cells in large animal models suggests they will be effective for several human hematopoietic diseases. Here, we review FV vector studies in large animal models, including the use of FV vectors with the mutant O6-methylguanine-DNA methyltransferase, MGMTP140K to increase the number of genetically modified cells after transplantation. In these studies, FV vectors have mediated efficient gene transfer to polyclonal repopulating cells using short ex vivo transduction protocols designed to minimize the negative effects of ex vivo culture on stem cell engraftment. In this regard, FV vectors appear superior to gammaretroviral vectors, which require longer ex vivo culture to effect efficient transduction. FV vectors have also compared favorably with lentiviral vectors when directly compared in the dog model. FV vectors have corrected leukocyte adhesion deficiency and pyruvate kinase deficiency in the dog large animal model. FV vectors also appear safer than gammaretroviral vectors based on a reduced frequency of integrants near promoters and also near proto-oncogenes in canine repopulating cells. Together, these studies suggest that FV vectors should be highly effective for several human hematopoietic diseases, including those that will require relatively high percentages of gene-modified cells to achieve clinical benefit.

  16. How effective is integrated vector management against malaria and lymphatic filariasis where the diseases are transmitted by the same vector?

    OpenAIRE

    Christopher M Stone; Lindsay, Steve W; Nakul Chitnis

    2014-01-01

    Background: The opportunity to integrate vector management across multiple vector-borne diseases is particularly plausible for malaria and lymphatic filariasis (LF) control where both diseases are transmitted by the same vector. To date most examples of integrated control targeting these diseases have been unanticipated consequences of malaria vector control, rather than planned strategies that aim to maximize the efficacy and take the complex ecological and biological interactions between th...

  17. Negotiating meaning for the symbolic expressions for vectors and vector equations in a classroom community of practice

    OpenAIRE

    Sweeney, George Franklin

    2012-01-01

    In this study, I analyze the development of meaning for the symbolic expressions for vectors and vector equations in an introductory, inquiry-oriented linear algebra course. Linear algebra is one of the first in-depth experiences that students have with vectors and vector equations, and as such my study examines these meanings in their formative and advanced states. The analysis in this study seeks to answer two fundamental questions : 1. What are the different meanings that this classroom co...

  18. Progressive Classification Using Support Vector Machines

    Science.gov (United States)

    Wagstaff, Kiri; Kocurek, Michael

    2009-01-01

    An algorithm for progressive classification of data, analogous to progressive rendering of images, makes it possible to compromise between speed and accuracy. This algorithm uses support vector machines (SVMs) to classify data. An SVM is a machine learning algorithm that builds a mathematical model of the desired classification concept by identifying the critical data points, called support vectors. Coarse approximations to the concept require only a few support vectors, while precise, highly accurate models require far more support vectors. Once the model has been constructed, the SVM can be applied to new observations. The cost of classifying a new observation is proportional to the number of support vectors in the model. When computational resources are limited, an SVM of the appropriate complexity can be produced. However, if the constraints are not known when the model is constructed, or if they can change over time, a method for adaptively responding to the current resource constraints is required. This capability is particularly relevant for spacecraft (or any other real-time systems) that perform onboard data analysis. The new algorithm enables the fast, interactive application of an SVM classifier to a new set of data. The classification process achieved by this algorithm is characterized as progressive because a coarse approximation to the true classification is generated rapidly and thereafter iteratively refined. The algorithm uses two SVMs: (1) a fast, approximate one and (2) slow, highly accurate one. New data are initially classified by the fast SVM, producing a baseline approximate classification. For each classified data point, the algorithm calculates a confidence index that indicates the likelihood that it was classified correctly in the first pass. Next, the data points are sorted by their confidence indices and progressively reclassified by the slower, more accurate SVM, starting with the items most likely to be incorrectly classified. The user

  19. ESTIMATING ELECTRIC FIELDS FROM VECTOR MAGNETOGRAM SEQUENCES

    International Nuclear Information System (INIS)

    Determining the electric field distribution on the Sun's photosphere is essential for quantitative studies of how energy flows from the Sun's photosphere, through the corona, and into the heliosphere. This electric field also provides valuable input for data-driven models of the solar atmosphere and the Sun-Earth system. We show how observed vector magnetogram time series can be used to estimate the photospheric electric field. Our method uses a 'poloidal-toroidal decomposition' (PTD) of the time derivative of the vector magnetic field. These solutions provide an electric field whose curl obeys all three components of Faraday's Law. The PTD solutions are not unique; the gradient of a scalar potential can be added to the PTD electric field without affecting consistency with Faraday's Law. We then present an iterative technique to determine a potential function consistent with ideal MHD evolution; but this field is also not a unique solution to Faraday's Law. Finally, we explore a variational approach that minimizes an energy functional to determine a unique electric field, a generalization of Longcope's 'Minimum Energy Fit'. The PTD technique, the iterative technique, and the variational technique are used to estimate electric fields from a pair of synthetic vector magnetograms taken from an MHD simulation; and these fields are compared with the simulation's known electric fields. The PTD and iteration techniques compare favorably to results from existing velocity inversion techniques. These three techniques are then applied to a pair of vector magnetograms of solar active region NOAA AR8210, to demonstrate the methods with real data. Careful examination of the results from all three methods indicates that evolution of the magnetic vector by itself does not provide enough information to determine the true electric field in the photosphere. Either more information from other measurements, or physical constraints other than those considered here are necessary to find

  20. Modelling transmission of vector-borne pathogens shows complex dynamics when vector feeding sites are limited.

    Directory of Open Access Journals (Sweden)

    Arik Kershenbaum

    Full Text Available The relationship between species richness and the prevalence of vector-borne disease has been widely studied with a range of outcomes. Increasing the number of host species for a pathogen may decrease infection prevalence (dilution effect, increase it (amplification, or have no effect. We derive a general model, and a specific implementation, which show that when the number of vector feeding sites on each host is limiting, the effects on pathogen dynamics of host population size are more complex than previously thought. The model examines vector-borne disease in the presence of different host species that are either competent or incompetent (i.e. that cannot transmit the pathogen to vectors as reservoirs for the pathogen. With a single host species present, the basic reproduction ratio R(0 is a non-monotonic function of the population size of host individuals (H, i.e. a value [Formula: see text] exists that maximises R(0. Surprisingly, if [Formula: see text] a reduction in host population size may actually increase R(0. Extending this model to a two-host species system, incompetent individuals from the second host species can alter the value of [Formula: see text] which may reverse the effect on pathogen prevalence of host population reduction. We argue that when vector-feeding sites on hosts are limiting, the net effect of increasing host diversity might not be correctly predicted using simple frequency-dependent epidemiological models.

  1. Two-hadron saturation for the pseudoscalar-vector-vector correlator and phenomenological applications

    Energy Technology Data Exchange (ETDEWEB)

    Husek, Tomas [Charles University, Faculty of Mathematics and Physics, Institute of Particle and Nuclear Physics, Prague 8 (Czech Republic); Leupold, Stefan [Uppsala Universitet, Institutionen foer Fysik och Astronomi, Box 516, Uppsala (Sweden)

    2015-12-15

    The pseudoscalar-vector-vector correlator is constructed using two meson multiplets in the vector and two in the pseudoscalar channel. The parameters are constrained by the operator product expansion at leading order where two or all three momenta are considered as large. Demanding in addition the Brodsky-Lepage limit one obtains (in the chiral limit) pion-vector-vector (πVV) correlator with only one free parameter. The singly virtual pion transition form factor F{sub π{sup 0}γγ*} and the decay width of ω → π{sup 0}γ are independent of this parameter and can serve as cross-checks of the results. The free parameter is determined from a fit of the ω-π transition form factor F{sub π{sup 0}ωγ*}. The resulting πVV correlator is used to calculate the decay widths ω → π{sup 0}e{sup +}e{sup -} and ω → π{sup 0}μ{sup +}μ{sup -} and finally the widths of the rare decay π{sup 0} → e{sup +}e{sup -} and of the Dalitz decay π{sup 0} → e{sup +}e{sup -}γ. Incorporating radiative QED corrections the calculations of π{sup 0} decays are compared to the KTeV results. We find a deviation of 2 σ or less for the rare pion decay. (orig.)

  2. PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile.

    Science.gov (United States)

    Croyle, M A; Le, H T; Linse, K D; Cerullo, V; Toietta, G; Beaudet, A; Pastore, L

    2005-04-01

    Transgene expression from helper-dependent adenoviral (HD-Ad) vectors is effective and long lasting, but not permanent. Their use is also limited by the host response against capsid proteins that precludes successful gene expression upon readministration. In this report, we test the hypothesis that PEGylation of HD-Ad reduces its toxicity and promotes transgene expression upon readministration. PEGylation did not compromise transduction efficiency in vitro and in vivo and reduced peak serum IL-6 levels two-fold. IL-12 and TNF-alpha levels were reduced three- and seven-fold, respectively. Thrombocytopenia was not detected in mice treated with the PEGylated vector. Serum transaminases were not significantly elevated in mice treated with either vector. Mice immunized with 1 x 10(11) particles of unmodified HD-Ad expressing human alpha-1 antitrypsin (hA1AT) were rechallenged 28 days later with 8 x 10(10) particles of unmodified or PEG-conjugated vector expressing beta-galactosidase. Trace levels of beta-galactosidase (52.23+/-19.2 pg/mg protein) were detected in liver homogenates of mice that received two doses of unmodified HD-Ad. Mice rechallenged with PEGylated HD-Ad produced significant levels of beta-galactosidase (5.1+/-0.4 x 10(5) pg/mg protein, P=0.0001). This suggests that PEGylation of HD-Ad vectors may be appropriate for their safe and efficient use in the clinic. PMID:15647765

  3. Thresholds and Smooth Transitions in Vector Autoregressive Models

    DEFF Research Database (Denmark)

    Hubrich, Kirstin; Teräsvirta, Timo

    This survey focuses on two families of nonlinear vector time series models, the family of Vector Threshold Regression models and that of Vector Smooth Transition Regression models. These two model classes contain incomplete models in the sense that strongly exogeneous variables are allowed...... in the equations. The emphasis is on stationary models, but the considerations also include nonstationary Vector Threshold Regression and Vector Smooth Transition Regression models with cointegrated variables. Model specification, estimation and evaluation is considered, and the use of the models illustrated...

  4. Vector Fields and the Unity of Mathematics and Physics

    OpenAIRE

    Gottlieb, Daniel Henry

    1992-01-01

    We give an argument that magnetic monopoles should not exist. It is based on the concept of the index of a vector field. The thrust of the argument is that indices of vector fields are invariants of space-time orientation and of coordinate changes, and thus physical vector fields should preserve indices. The index is defined inductively by means of an equation called the Law of Vector Fields. We give extended philosophical arguments that this Law of Vector Fields should play an important role...

  5. Effective SIMD Vectorization for Intel Xeon Phi Coprocessors

    Directory of Open Access Journals (Sweden)

    Xinmin Tian

    2015-01-01

    Full Text Available Efficiently exploiting SIMD vector units is one of the most important aspects in achieving high performance of the application code running on Intel Xeon Phi coprocessors. In this paper, we present several effective SIMD vectorization techniques such as less-than-full-vector loop vectorization, Intel MIC specific alignment optimization, and small matrix transpose/multiplication 2D vectorization implemented in the Intel C/C++ and Fortran production compilers for Intel Xeon Phi coprocessors. A set of workloads from several application domains is employed to conduct the performance study of our SIMD vectorization techniques. The performance results show that we achieved up to 12.5x performance gain on the Intel Xeon Phi coprocessor. We also demonstrate a 2000x performance speedup from the seamless integration of SIMD vectorization and parallelization.

  6. Chern-Simons Couplings and Inequivalent Vector-Tensor Multiplets

    CERN Document Server

    Claus, P; Faux, M; Termonia, P

    1996-01-01

    The off-shell vector-tensor multiplet is considered in an arbitrary background of N=2 vector supermultiplets. We establish the existence of two inequivalent versions, characterized by different Chern-Simons couplings. In one version the vector field of the vector-tensor multiplet is contained quadratically in the Chern-Simons term, which implies nonlinear terms in the supersymmetry transformations and equations of motion. In the second version, which requires a background of at least two abelian vector supermultiplets, the supersymmetry transformations remain at most linear in the vector-tensor components. This version is of the type known to arise from reduction of tensor supermultiplets in six dimensions. Our work applies to any number of vector-tensor multiplets.

  7. Vectorization of molecular dynamics Fortran programs using the cyber 205 vector processing computer

    Science.gov (United States)

    Vogelsang, R.; Schoen, M.; Hoheisel, C.

    1983-11-01

    A concept of vectorization of molecular dynamics Fortran programs for the use of the Cyber 205 machine is presented. It is shown that for calculations with larger particle systems the program runs faster on the 205 than on the Cray-1 by about a factor of two. Against conventional computers like the Cyber 175 an acceleration by a factor 10-15 is expected. A bit control vector is used instead of a neighbour list, which in principal provides calculations up to 6912 particles for the memory capacity of the Cyber 205. However, because the application of the bit vector requires computation times which grow proportional to N2, the CPU time for particle numbers of more than 2048 becomes prohibitively large.

  8. Wavefront aberration function in terms of R. V. Shack's vector product and Zernike polynomial vectors.

    Science.gov (United States)

    Gray, Robert W; Rolland, Jannick P

    2015-10-01

    Previous papers have shown how, for rotationally symmetric optical imaging systems, nodes in the field dependence of the wavefront aberration function develop when a rotationally symmetric optical surface within an imaging optical system is decentered and/or tilted. In this paper, we show how Shack's vector product (SVP) can be used to express the wavefront aberration function and to define vectors in terms of the Zernike polynomials. The wavefront aberration function is then expressed in terms of the Zernike vectors. It is further shown that SVP fits within the framework of two-dimensional geometric algebra (GA). Within the GA framework, an equation for the third-order node locations for the binodal astigmatism term that emerge in the presence of tilts and decenters is then demonstrated. A computer model of a three-mirror telescope system is used to demonstrate the validity of the mathematical development. PMID:26479937

  9. Pseudocalar meson and vector meson interactions and dynamically generated axial-vector mesons

    OpenAIRE

    Zhou, Yu; Ren, Xiu-Lei; Chen, Hua-Xing; Geng, Li-Sheng

    2014-01-01

    The axial-vector mesons $a_1(1260)$, $b_1(1235)$, $f_1(1285)$, $h_1(1170)$, $h_1(1380)$, and $K_1(1270)$ are dynamically generated in the unitized chiral perturbation theory. Such a picture has been tested extensively in the past few years. In this work, we calculate the interaction kernel up to $\\mathcal{O}(p^2)$ and study the impact on the dynamically generated axial-vector states. In anticipation of future lattice QCD simulations, we calculate the scattering lengths and the pole positions ...

  10. Plant viral vectors based on tobamoviruses.

    Science.gov (United States)

    Yusibov, V; Shivprasad, S; Turpen, T H; Dawson, W; Koprowski, H

    1999-01-01

    The potential of plant virus-based transient expression vectors is substantial. One objective is the production of large quantities of foreign peptides or proteins. At least one commercial group (Biosource Technologies) is producing large quantities of product in the field, has built factories to process truck-loads of material and soon expects to market virus-generated products. In the laboratory, large amounts of protein have been produced for structural or biochemical analyses. An important aspect of producing large amounts of a protein or peptide is to make the product easily purifiable. This has been done by attaching peptides or proteins to easily purified units such as virion particles or by exporting proteins to the apoplast so that purification begins with a highly enriched product. For plant molecular biology, virus-based vectors have been useful in identifying previously unknown genes by overexpression or silencing or by expression in different genotypes. Also, foreign peptides fused to virions are being used as immunogens for development of antisera for experimental use or as injected or edible vaccines for medical use. As with liposomes and microcapsules, plant cells and plant viruses are also expected to provide natural protection for the passage of antigen through the gastrointestinal tract. Perhaps the greatest advantage of plant virus-based transient expression vectors is their host, plants. For the production of large amounts of commercial products, plants are one of the most economical and productive sources of biomass. They also present the advantages of lack of contamination with animal pathogens, relative ease of genetic manipulation and the presence eukaryotic protein modification machinery.

  11. Plant viral vectors based on tobamoviruses.

    Science.gov (United States)

    Yusibov, V; Shivprasad, S; Turpen, T H; Dawson, W; Koprowski, H

    1999-01-01

    The potential of plant virus-based transient expression vectors is substantial. One objective is the production of large quantities of foreign peptides or proteins. At least one commercial group (Biosource Technologies) is producing large quantities of product in the field, has built factories to process truck-loads of material and soon expects to market virus-generated products. In the laboratory, large amounts of protein have been produced for structural or biochemical analyses. An important aspect of producing large amounts of a protein or peptide is to make the product easily purifiable. This has been done by attaching peptides or proteins to easily purified units such as virion particles or by exporting proteins to the apoplast so that purification begins with a highly enriched product. For plant molecular biology, virus-based vectors have been useful in identifying previously unknown genes by overexpression or silencing or by expression in different genotypes. Also, foreign peptides fused to virions are being used as immunogens for development of antisera for experimental use or as injected or edible vaccines for medical use. As with liposomes and microcapsules, plant cells and plant viruses are also expected to provide natural protection for the passage of antigen through the gastrointestinal tract. Perhaps the greatest advantage of plant virus-based transient expression vectors is their host, plants. For the production of large amounts of commercial products, plants are one of the most economical and productive sources of biomass. They also present the advantages of lack of contamination with animal pathogens, relative ease of genetic manipulation and the presence eukaryotic protein modification machinery. PMID:10394716

  12. Quantum nonlinear lattices and coherent state vectors

    DEFF Research Database (Denmark)

    Ellinas, Demosthenes; Johansson, M.; Christiansen, Peter Leth

    1999-01-01

    Quantized nonlinear lattice models are considered for two different classes, boson and fermionic ones. The quantum discrete nonlinear Schrodinger model (DNLS) is our main objective, but its so called modified discrete nonlinear (MDNLS) version is also included, together with the fermionic polaron...... for the state vectors invokes the study of the Riemannian and symplectic geometry of the CSV manifolds as generalized phase spaces. Next, we investigate analytically and numerically the behavior of mean values and uncertainties of some physically interesting observables as well as the modifications...

  13. Differential geometry of complex vector bundles

    CERN Document Server

    Kobayashi, Shoshichi

    2014-01-01

    Holomorphic vector bundles have become objects of interest not only to algebraic and differential geometers and complex analysts but also to low dimensional topologists and mathematical physicists working on gauge theory. This book, which grew out of the author's lectures and seminars in Berkeley and Japan, is written for researchers and graduate students in these various fields of mathematics. Originally published in 1987. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeto

  14. Versatile cloning vector for Pseudomonas aeruginosa.

    OpenAIRE

    Wood, D O; Hollinger, M F; Tindol, M B

    1981-01-01

    A pBR322:RSF1010 composite plasmid, constructed in vitro, was used as a cloning vector in Pseudomonas aeruginosa. This nonamplifiable plasmid, pMW79, has a molecular weight of 8.4 X 10(6) and exists as a multicopy plasmid in both P. aeruginosa and Escherichia coli. In P. aeruginosa strain PAO2003, pMW79 conferred resistance to carbenicillin and tetracycline. Characterization of pMW79 with restriction enzymes revealed that four enzymes (BamHI, SalI, HindIII, and HpaI) cleaved the plasmid at un...

  15. Robust Video Stabilization Based on Motion Vectors

    Institute of Scientific and Technical Information of China (English)

    宋利; 周源华; 周军

    2005-01-01

    This paper proposes a new robust video stabilization algorithm to remove unwanted vibrations in video sequences. A complete theoretical analysis is first established for video stabilization, providing a basis for new stabilization algorithm. Secondly, a new robust global motion estimation (GME) algorithm is proposed. Different from classic methods, the GME algorithm is based on spatlal-temporal filtered motion vectors computed by block-matching methods. In addition, effective schemes are employed in correction phase to prevent boundary artifacts and error accumulation. Experiments show that the proposed algorithm has satisfactory stabilization effects while maintaining good tradeoff between speed and precision.

  16. Hydrogen: an energy vector for the future?

    Energy Technology Data Exchange (ETDEWEB)

    His, St

    2004-07-01

    Used today in various industrial sectors including refining and chemicals, hydrogen is often presented as a promising energy vector for the transport sector. However, its balance sheet presents disadvantages as well as advantages. For instance, some of its physical characteristics are not very well adapted to transport use and hydrogen does not exist in pure form. Hydrogen technologies can offer satisfactory environmental performance in certain respects, but remain handicapped by costs too high for large-scale development. A great deal of research will be required to develop mass transport application. (author)

  17. Pulsed 3-Axis Vector SERF Magnetometer

    Science.gov (United States)

    Hedges, Morgan; Romalis, Michael

    2016-05-01

    We demonstrate a 3-axis atomic vector magnetometer operating in the SERF regime, using a single beam path, and capable of operating in Earth's field using field feedback. It has similar sensitivity along all 3 axes that is fundamentally limited by photon and atom shot noise. The scheme uses a high intensity pump pulse to polarize Rb atoms in ~ 1 μs and a sequence of magnetic field pulses applied while the atoms are monitored during free precession. The sequence used provides minimal sensitivity to pulse errors, while also allowing unambiguous discrimination between external magnetic fields and misalignment between laser and magnetic coil axes.

  18. Vector Control Based on SVPWM for ACIM

    Directory of Open Access Journals (Sweden)

    Zhu Jun

    2013-05-01

    Full Text Available To solve the large torque ripple and current harmonics, low DC bus voltage problems, a new control strategy is proposed for AC induction motor by using space vector pulse width modulation, so that the static and dynamic performance are improved. The system simulation experiment mode was established based on SVPWM to verify the effectiveness of the system control mode. It is showed that it can reduce the current ripple and torque ripple, improve the utilization of DC bus voltage. It means that the control strategy based SVPWM can improve dynamic and static performance effectively for the ACIM servo system.

  19. [Climate- and vector-borne diseases

    DEFF Research Database (Denmark)

    Bygbjerg, I.C.; Schioler, K.L.; Konradsen, F.

    2009-01-01

    The predicted changes in climate have raised concerns that vector-borne diseases may emerge or expand in tempered regions. Malaria, leishmaniasis and tick-borne illnesses are discussed in terms of climate change and their endemic potential, especially in Denmark. While climate may play an important...... role in disease patterns, it is evident that transmission potential is governed by a complex of factors, including socio-economy, health-care capacity and ecology. In Denmark, malaria and leishmaniasis are unlikely to become public health problems, whereas the potential for tick-borne illnesses may...

  20. Vector magnetometer as an attitude determining instrument

    Science.gov (United States)

    Pietila, R.; Dunn, W. R., Jr.

    1974-01-01

    The solid state vector magnetometer sensor system is presented for the accuracy and reliability of existing systems, and for providing independent measures of attitude. Since a large number of aircraft heading reference systems depend on measurement of the earth's magnetic field, it can be shown that by substituting a 3-axis magnetometer for the remote sensing unit, both heading and attitude measurement functions can be derived using common elements. Sample calculations are made using the earth's magnetic field data acquired during actual flight conditions.