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Sample records for alternative sigma factor

  1. The alternative sigma factor σL of L. monocytogenes promotes growth under diverse environmental stresses

    OpenAIRE

    Raimann, Eveline

    2009-01-01

    Listeria monocytogenes are important food-borne pathogens that can cause outbreaks of serious human disease. These organisms frequently colonize and proliferate on preserved food products despite exposure to stress conditions induced by low storage temperatures, inclusion of organic acid based preservatives and high osmolarity. To assess alternative sigma factor σL contributions to such stress resistance of L.monocytogenes, quantitative RT-PCR assays and sigL gene deletion mutagenesis were ap...

  2. Alternative sigma factor σH activates competence gene expression in Lactobacillus sakei

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    Schmid Solveig

    2012-03-01

    Full Text Available Abstract Background Alternative sigma factors trigger various adaptive responses. Lactobacillus sakei, a non-sporulating meat-borne bacterium, carries an alternative sigma factor seemingly orthologous to σH of Bacillus subtilis, best known for its contribution to the initiation of a large starvation response ultimately leading to sporulation. As the role of σH-like factors has been little studied in non-sporulating bacteria, we investigated the function of σH in L. sakei. Results Transcription of sigH coding for σH was hardly affected by entry into stationary phase in our laboratory conditions. Twenty-five genes potentially regulated by σH in L. sakei 23 K were revealed by genome-wide transcriptomic profiling of sigH overexpression and/or quantitative PCR analysis. More than half of them are involved in the synthesis of a DNA uptake machinery linked to genetic competence, and in DNA metabolism; however, σH overproduction did not allow detectable genetic transformation. σH was found to be conserved in the L. sakei species. Conclusion Our results are indicative of the existence of a genetic competence state activated by σH in L. sakei, and sustain the hypothesis that σH-like factors in non sporulating Firmicutes share this common function with the well-known ComX of naturally transformable streptococci.

  3. Human Serum-Specific Activation of Alternative Sigma Factors, the Stress Responders in Aggregatibacter actinomycetemcomitans

    Science.gov (United States)

    Tang-Siegel, Gaoyan; Bumgarner, Roger; Ruiz, Teresa; Kittichotirat, Weerayuth; Chen, Weizhen; Chen, Casey

    2016-01-01

    Aggregatibacter actinomycetemcomitans, a known pathogen causing periodontal disease and infective endocarditis, is a survivor in the periodontal pocket and blood stream; both environments contain serum as a nutrient source. To screen for unknown virulence factors associated with this microorganism, A. actinomycetemcomitans was grown in serum-based media to simulate its in vivo environment. Different strains of A. actinomycetemcomitans showed distinct growth phenotypes only in the presence of human serum, and they were grouped into high- and low-responder groups. High-responders comprised mainly serotype c strains, and showed an unusual growth phenomenon, featuring a second, rapid increase in turbidity after 9-h incubation that reached a final optical density 2- to 7-fold higher than low-responders. Upon further investigation, the second increase in turbidity was not caused by cell multiplication, but by cell death. Whole transcriptomic analysis via RNA-seq identified 35 genes that were up-regulated by human serum, but not horse serum, in high-responders but not in low-responders, including prominently an alternative sigma factor rpoE (σE). A lacZ reporter construct driven by the 132-bp rpoE promoter sequence of A. actinomycetemcomitans responded dramatically to human serum within 90 min of incubation only when the construct was carried by a high responder strain. The rpoE promoter is 100% identical among high- and low-responder strains. Proteomic investigation showed potential interactions between human serum protein, e.g. apolipoprotein A1 (ApoA1) and A. actinomycetemcomitans. The data clearly indicated a different activation process for rpoE in high- versus low-responder strains. This differential human serum-specific activation of rpoE, a putative extra-cytoplasmic stress responder and global regulator, suggests distinct in vivo adaptations among different strains of A. actinomycetemcomitans. PMID:27490177

  4. Alternative sigma factor RpoN and its modulation protein YhbH are indispensable for Erwinia amylovora virulence.

    Science.gov (United States)

    Ancona, Veronica; Li, Wenting; Zhao, Youfu

    2014-01-01

    In Erwinia amylovora, ECF (extracytoplasmic functions) alternative sigma factor HrpL regulates the transcription of hrp (hypersensitive response and pathogenicity)-type III secretion system (T3SS) genes by binding to a consensus sequence known as the hrp box in hrp gene promoters. In turn, the expression of hrpL has been proposed to be positively controlled by alternative sigma factor 54 (σ(54)) (RpoN) and HrpS, a member of the σ(54) enhancer-binding proteins (EBPs). However, the function of RpoN has not been characterized genetically in E. amylovora. In this study, we investigated the role of RpoN, a nitrogen limitation sigma factor, and its modulation protein YhbH, a novel ribosome-associated protein, in E. amylovora virulence. Our results showed that mutations in hrpS, hrpL, rpoN and yhbH, but not yfiA and rmf3, resulted in a nonpathogenic phenotype on immature pear fruits and apple shoots. Consistently, the expression of T3SS genes, including hrpL, dspE, hrpN and hrpA, was barely detected in hrpS, hrpL, rpoN and yhbH mutants. These mutants were also not capable of eliciting a hypersensitive response (HR) on tobacco; however, the overexpression of hrpL using an inducible promoter rescued the HR-eliciting abilities of these mutants. These results suggest that a sigma factor cascade exists in the regulatory networks of E. amylovora and regulates important virulence factors. On the basis of this study and previously reported data, a model is proposed for the regulation of T3SS in E. amylovora.

  5. Decoding Biomass-Sensing Regulons of Clostridium thermocellum Alternative Sigma-I Factors in a Heterologous Bacillus subtilis Host System.

    Directory of Open Access Journals (Sweden)

    Iván Muñoz-Gutiérrez

    Full Text Available The Gram-positive, anaerobic, cellulolytic, thermophile Clostridium (Ruminiclostridium thermocellum secretes a multi-enzyme system called the cellulosome to solubilize plant cell wall polysaccharides. During the saccharolytic process, the enzymatic composition of the cellulosome is modulated according to the type of polysaccharide(s present in the environment. C. thermocellum has a set of eight alternative RNA polymerase sigmafactors that are activated in response to extracellular polysaccharides and share sequence similarity to the Bacillus subtilis σI factor. The aim of the present work was to demonstrate whether individual C. thermocellum σI-like factors regulate specific cellulosomal genes, focusing on C. thermocellum σI6 and σI3 factors. To search for putative σI6- and σI3-dependent promoters, bioinformatic analysis of the upstream regions of the cellulosomal genes was performed. Because of the limited genetic tools available for C. thermocellum, the functionality of the predicted σI6- and σI3-dependent promoters was studied in B. subtilis as a heterologous host. This system enabled observation of the activation of 10 predicted σI6-dependent promoters associated with the C. thermocellum genes: sigI6 (itself, Clo1313_2778, xyn11B (Clo1313_0522, xyn10D (Clo1313_0177, xyn10Z (Clo1313_2635, xyn10Y (Clo1313_1305, cel9V (Clo1313_0349, cseP (Clo1313_2188, sigI1 (Clo1313_2174, cipA (Clo1313_0627, and rsgI5 (Clo1313_0985. Additionally, we observed the activation of 4 predicted σI3-dependent promoters associated with the C. thermocellum genes: sigI3 (itself, Clo1313_1911, pl11 (Clo1313_1983, ce12 (Clo1313_0693 and cipA. Our results suggest possible regulons of σI6 and σI3 in C. thermocellum, as well as the σI6 and σI3 promoter consensus sequences. The proposed -35 and -10 promoter consensus elements of σI6 are CNNAAA and CGAA, respectively. Additionally, a less conserved CGA sequence next to the C in the -35 element and a highly

  6. Functional modules of sigma factor regulons guarantee adaptability and evolvability

    Science.gov (United States)

    Binder, Sebastian C.; Eckweiler, Denitsa; Schulz, Sebastian; Bielecka, Agata; Nicolai, Tanja; Franke, Raimo; Häussler, Susanne; Meyer-Hermann, Michael

    2016-02-01

    The focus of modern molecular biology turns from assigning functions to individual genes towards understanding the expression and regulation of complex sets of molecules. Here, we provide evidence that alternative sigma factor regulons in the pathogen Pseudomonas aeruginosa largely represent insulated functional modules which provide a critical level of biological organization involved in general adaptation and survival processes. Analysis of the operational state of the sigma factor network revealed that transcription factors functionally couple the sigma factor regulons and significantly modulate the transcription levels in the face of challenging environments. The threshold quality of newly evolved transcription factors was reached faster and more robustly in in silico testing when the structural organization of sigma factor networks was taken into account. These results indicate that the modular structures of alternative sigma factor regulons provide P. aeruginosa with a robust framework to function adequately in its environment and at the same time facilitate evolutionary change. Our data support the view that widespread modularity guarantees robustness of biological networks and is a key driver of evolvability.

  7. Extracytoplasmic function sigma factors in Pseudomonas syringae

    DEFF Research Database (Denmark)

    Kiil, Kristoffer; Oguiza, J.A.; Ussery, D.W.

    2005-01-01

    Genome analyses of the plant pathogens Pseudomonas syringae pv. tomato DC3000, pv. syringae B728a and pv. phaseolicola 1448A reveal fewer extracytoplasmic function (ECF) sigma factors than in related Pseudomonads with different lifestyles. We highlight the presence of a P. syringae-specific ECF...

  8. Genome-scale reconstruction of the sigma factor network in Escherichia coli: topology and functional states

    DEFF Research Database (Denmark)

    Cho, Byung-Kwan; Kim, Donghyuk; Knight, Eric M.;

    2014-01-01

    and negative regulation by alternative s-factors. Comparison with sigma-factor binding in Klebsiella pneumoniae showed that transcriptional regulation of conserved genes in closely related species is unexpectedly divergent. Conclusions: The reconstructed network reveals the regulatory complexity...

  9. Exploring the role of sigma factor gene expression on production by Corynebacterium glutamicum: sigma factor H and FMN as example

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    Hironori eTaniguchi

    2015-07-01

    Full Text Available Bacteria are known to cope with environmental changes by using alternative sigma factors binding to RNA polymerase core enzyme. Sigma factor is one of the targets to modify transcription regulation in bacteria and to influence production capacities. In this study, the effect of overexpressing each annotated sigma factor gene in C. glutamicum WT was assayed using an IPTG inducible plasmid system and different IPTG concentrations. It was revealed that growth was severely decreased when sigD or sigH were overexpressed with IPTG concentrations higher than 50 μM. Overexpression of sigH led to an obvious phenotypic change, a yellow-colored supernatant. HPLC analysis revealed that riboflavin was excreted to the medium when sigH was overexpressed and DNA microarray analysis confirmed increased expression of riboflavin biosynthesis genes. In addition, genes for enzymes related to the pentose phosphate pathway and for enzymes dependent on FMN, FAD or NADPH as cofactor were upregulated when sigH was overexpressed. To test if sigH overexpression can be exploited for production of riboflavin-derived FMN or FAD, the endogenous gene for bifunctional riboflavin kinase/FMN adenyltransferase was co-expressed with sigH from a plasmid. Balanced expression of sigH and ribF improved accumulation of riboflavin (19.8 ± 0.3 μM and allowed for its conversion to FMN (33.1 ± 1.8 μM in the supernatant. While a proof-of-concept was reached, conversion was not complete and titers were not high. This study revealed that inducible and gradable overexpression of sigma factor genes is an interesting approach to switch gene expression profiles and to discover untapped potential of bacteria for chemical production.

  10. An extra-cytoplasmic function sigma factor and anti-sigma factor control carotenoid biosynthesis in Azospirillum brasilense.

    Science.gov (United States)

    Thirunavukkarasu, Nagarajan; Mishra, Mukti Nath; Spaepen, Stijn; Vanderleyden, Jos; Gross, Carol A; Tripathi, Anil K

    2008-07-01

    Strains Sp7 and Cd of Azospirillum brasilense, a plant growth-promoting rhizobacterium, differ in synthesis of carotenoids. While colonies of strain Sp7 have a white-cream colour on plates, colonies of strain Cd are orange-pink coloured because of the synthesis of carotenoids. Screening of a mini-Tn5 mutant library of A. brasilense Sp7 revealed two orange-pink-coloured mutants that produced carotenoids. Cloning and sequencing of the Tn5 flanking region in both the carotenoid-producing mutants of Sp7 revealed insertion of Tn5 in an ORF encoding anti-sigma factor, a ChrR-like protein. The upstream region of the Tn5-mutated ORF contained another ORF that encoded an extra-cytoplasmic function (ECF)-class sigma factor (sigma(E), RpoE). When the nucleotide sequences of the corresponding ORFs from the carotenoid-producing strain Cd were analysed, the sequence of the Cd sigma(E) was identical to that of the carotenoid non-producing strain Sp7, but the Cd anti-sigma(E) ORF had a deletion that caused frame shifting and creation of a stop codon. This resulted in the premature termination of the protein, which was about 7 kDa smaller than the Sp7 anti-sigma(E). Cloning of Sp7 anti-sigma(E) in a broad-host-range expression vector and expression in A. brasilense Cd and in the anti-sigma(E) knockout mutant of A. brasilense Sp7 resulted in the inhibition of carotenoid synthesis. Similarly, cloning and overexpression of A. brasilense Sp7 sigma(E) in A. brasilense Sp7 resulted in the production of carotenoids. These observations clearly indicate that carotenoid synthesis in A. brasilense is controlled by sigma(E) with its cognate anti-sigma(E).

  11. Interaction of sigma factor sigmaN with Escherichia coli RNA polymerase core enzyme.

    Science.gov (United States)

    Scott, D J; Ferguson, A L; Gallegos, M T; Pitt, M; Buck, M; Hoggett, J G

    2000-12-01

    The equilibrium binding and kinetics of assembly of the DNA-dependent RNA polymerase (RNAP) sigma(N)-holoenzyme has been investigated using biosynthetically labelled 7-azatryptophyl- (7AW)sigma(N). The spectroscopic properties of such 7AW proteins allows their absorbance and fluorescence to be monitored selectively, even in the presence of high concentrations of other tryptophan-containing proteins. The 7AWsigma(N) retained its biological activity in stimulating transcription from sigma(N)-specific promoters, and in in vitro gel electrophoresis assays of binding to core RNAP from Escherichia coli. Furthermore, five Trp-->Ala single mutants of sigma(N) were shown to support growth under conditions of nitrogen limitation, and showed comparable efficiency in activating the sigma(N)-dependent nifH promoter in vivo, indicating that none of the tryptophan residues were essential for activity. The equilibrium binding of 7AWsigma(N) to core RNAP was examined by analytical ultracentrifugation. In sedimentation equilibrium experiments, absorbance data at 315 nm (which reports selectively on the distribution of free and bound 7AWsigma(N)) established that a 1:1 complex was formed, with a dissociation constant lower than 2 microM. The kinetics of the interaction between 7AWsigma(N) and core RNAP was investigated using stopped-flow spectrofluorimetry. A biphasic decrease in fluorescence intensity was observed when samples were excited at 280 nm, whereas only the slower of the two phases was observed at 315 nm. The kinetic data were analysed in terms of a mechanism in which a fast bimolecular association of sigma(N) with core RNAP is followed by a relatively slow isomerization step. The consequences of these findings on the competition between sigma(N) and the major sigma factor, sigma(70), in Escherichia coli are discussed. PMID:11085949

  12. Six Sigma: Problems, Limitations, Critical Success Factors and Future Prospects

    OpenAIRE

    Paulo Mazieiro Pohlmann; Marco Antônio Ferreira

    2015-01-01

    Six Sigma is a business strategy based on objective decision making and problem solving in order to achieve, maintain and maximize business success through understanding and meeting the needs of customers. The visualization of this methodology as a powerful tool in reducing variability and improving quality led to the interest in performing this bibliographical study, whose purpose was to assess the critical success factors and future prospects of this managerial system. A survey ...

  13. Exploring the potential of sigma factors for strain development in Corynebacterium glutamicum

    OpenAIRE

    Taniguchi, Hironori

    2016-01-01

    A sigma factor is one of the components of RNA polymerase holoenzyme and responsible for promoter recognition and transcription initiation. Bacteria usually possess multiple genes encoding sigma factors and strictly control their activity. Activation of a specific sigma factor alters the promoter recognition of the RNA polymerase holoenzyme and enhances the transcription of a specific set of genes with similar promoter sequences. Therefore, sigma factors can be used for activating expression ...

  14. Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.

    Science.gov (United States)

    Chauhan, Rinki; Ravi, Janani; Datta, Pratik; Chen, Tianlong; Schnappinger, Dirk; Bassler, Kevin E; Balázsi, Gábor; Gennaro, Maria Laura

    2016-03-31

    Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate bacterial adaptive responses to noxious environments. Here we reconstruct the complete sigma factor regulatory network of the human pathogen Mycobacterium tuberculosis by an integrated approach. The approach combines identification of direct regulatory interactions between M. tuberculosis sigma factors in an E. coli model system, validation of selected links in M. tuberculosis, and extensive literature review. The resulting network comprises 41 direct interactions among all 13 sigma factors. Analysis of network topology reveals (i) a three-tiered hierarchy initiating at master regulators, (ii) high connectivity and (iii) distinct communities containing multiple sigma factors. These topological features are likely associated with multi-layer signal processing and specialized stress responses involving multiple sigma factors. Moreover, the identification of overrepresented network motifs, such as autoregulation and coregulation of sigma and anti-sigma factor pairs, provides structural information that is relevant for studies of network dynamics.

  15. The sigma factor sigma s affects antibiotic production and biological control activity of Pseudomonas fluorescens Pf-5.

    OpenAIRE

    Sarniguet, A.; Kraus, J.; Henkels, M D; Muehlchen, A M; Loper, J E

    1995-01-01

    Pseudomonas fluorescens Pf-5, a rhizosphere-inhabiting bacterium that suppresses several soilborne pathogens of plants, produces the antibiotics pyrrolnitrin, pyoluteorin, and 2,4-diacetylphloroglucinol. A gene necessary for pyrrolnitrin production by Pf-5 was identified as rpoS, which encodes the stationary-phase sigma factor sigma s. Several pleiotropic effects of an rpoS mutation in Escherichia coli also were observed in an RpoS- mutant of Pf-5. These included sensitivities of stationary-p...

  16. Characterizing the interplay betwen mulitple levels of organization within bacterial sigma factor regulatory networks

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Qiu [University of California, San Diego; Nagarajan, Harish [University of California, San Diego; Embree, Mallory [University of California, San Diego; Shieu, Wendy [University of California, San Diego; Abate, Elisa [University of California, San Diego; Juarez, Katy [Universidad Nacional Autonoma de Mexico (UNAM); Cho, Byung-Kwan [University of California, San Diego; Elkins, James G [ORNL; Nevin, Kelly P. [University of Massachusetts, Amherst; Barrett, Christian [University of California, San Diego; Lovley, Derek [University of Massachusetts, Amherst; Palsson, Bernhard O. [University of California, San Diego; Zengler, Karsten [University of California, San Diego

    2013-01-01

    Bacteria contain multiple sigma factors, each targeting diverse, but often overlapping sets of promoters, thereby forming a complex network. The layout and deployment of such a sigma factor network directly impacts global transcriptional regulation and ultimately dictates the phenotype. Here we integrate multi-omic data sets to determine the topology, the operational, and functional states of the sigma factor network in Geobacter sulfurreducens, revealing a unique network topology of interacting sigma factors. Analysis of the operational state of the sigma factor network shows a highly modular structure with sN being the major regulator of energy metabolism. Surprisingly, the functional state of the network during the two most divergent growth conditions is nearly static, with sigma factor binding profiles almost invariant to environmental stimuli. This first comprehensive elucidation of the interplay between different levels of the sigma factor network organization is fundamental to characterize transcriptional regulatory mechanisms in bacteria.

  17. Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes.

    Science.gov (United States)

    Gopalkrishnan, Saumya; Nicoloff, Herve; Ades, Sarah E

    2014-08-01

    The E. coli alternative sigma factor, σ(E) , transcribes genes required to maintain the cell envelope and is activated by conditions that destabilize the envelope. σ(E) is also activated during entry into stationary phase in the absence of envelope stress by the alarmone (p)ppGpp. (p)ppGpp controls a large regulatory network, reducing expression of σ(70) -dependent genes required for rapid growth and activating σ(70) -dependent and alternative sigma factor-dependent genes required for stress survival. The DksA protein often potentiates the effects of (p)ppGpp. Here we examine regulation of σ(E) by (p)ppGpp and DksA following starvation for nutrients. We find that (p)ppGpp is required for increased σ(E) activity under all conditions tested, but the requirement for DksA varies. DksA is required during amino acid starvation, but is dispensable during phosphate starvation. In contrast, regulation of σ(S) is (p)ppGpp- and DksA-dependent under all conditions tested, while negative regulation of σ(70) is DksA- but not (p)ppGpp-dependent during phosphate starvation, yet requires both factors during amino acid starvation. These findings suggest that the mechanism of transcriptional regulation by (p)ppGpp and/or DksA cannot yet be explained by a unifying model and is specific to individual promoters, individual holoenzymes, and specific starvation conditions.

  18. Six Sigma: Problems, Limitations, Critical Success Factors and Future Prospects

    Directory of Open Access Journals (Sweden)

    Paulo Mazieiro Pohlmann

    2015-12-01

    Full Text Available Six Sigma is a business strategy based on objective decision making and problem solving in order to achieve, maintain and maximize business success through understanding and meeting the needs of customers. The visualization of this methodology as a powerful tool in reducing variability and improving quality led to the interest in performing this bibliographical study, whose purpose was to assess the critical success factors and future prospects of this managerial system. A survey was conducted in order to discover the main critical success factors of the implementation of the methodology in organizations, among which stood out the proper selection of projects, connecting the project with the business strategy, customer focus, financial, human and infrastructure resources, the involvement of senior management, professional training, and cultural change.

  19. Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity.

    Science.gov (United States)

    Weber, Harald; Polen, Tino; Heuveling, Johanna; Wendisch, Volker F; Hengge, Regine

    2005-03-01

    The sigmaS (or RpoS) subunit of RNA polymerase is the master regulator of the general stress response in Escherichia coli. While nearly absent in rapidly growing cells, sigmaS is strongly induced during entry into stationary phase and/or many other stress conditions and is essential for the expression of multiple stress resistances. Genome-wide expression profiling data presented here indicate that up to 10% of the E. coli genes are under direct or indirect control of sigmaS and that sigmaS should be considered a second vegetative sigma factor with a major impact not only on stress tolerance but on the entire cell physiology under nonoptimal growth conditions. This large data set allowed us to unequivocally identify a sigmaS consensus promoter in silico. Moreover, our results suggest that sigmaS-dependent genes represent a regulatory network with complex internal control (as exemplified by the acid resistance genes). This network also exhibits extensive regulatory overlaps with other global regulons (e.g., the cyclic AMP receptor protein regulon). In addition, the global regulatory protein Lrp was found to affect sigmaS and/or sigma70 selectivity of many promoters. These observations indicate that certain modules of the sigmaS-dependent general stress response can be temporarily recruited by stress-specific regulons, which are controlled by other stress-responsive regulators that act together with sigma70 RNA polymerase. Thus, not only the expression of genes within a regulatory network but also the architecture of the network itself can be subject to regulation. PMID:15716429

  20. A Comprehensive Framework for Six Sigma Critical Success Factors With an Experience on a Developing Country

    OpenAIRE

    Shahin, Arash

    2010-01-01

    This paper reviewed literature on the CSFs of Six Sigma implementation in different sectors, worldwide and a comprehensive framework was proposed for Six Sigma critical success factors (CSFs). All those factors was extracted from literature review and seem essential for optimizing financial return from Six Sigma projects and for achieving the full potential of its application in all organizations. A case study was also conducted, in which the CSFs were prioritized in five major car maker comp...

  1. The sigma factor sigma s affects antibiotic production and biological control activity of Pseudomonas fluorescens Pf-5.

    Science.gov (United States)

    Sarniguet, A; Kraus, J; Henkels, M D; Muehlchen, A M; Loper, J E

    1995-12-19

    Pseudomonas fluorescens Pf-5, a rhizosphere-inhabiting bacterium that suppresses several soilborne pathogens of plants, produces the antibiotics pyrrolnitrin, pyoluteorin, and 2,4-diacetylphloroglucinol. A gene necessary for pyrrolnitrin production by Pf-5 was identified as rpoS, which encodes the stationary-phase sigma factor sigma s. Several pleiotropic effects of an rpoS mutation in Escherichia coli also were observed in an RpoS- mutant of Pf-5. These included sensitivities of stationary-phase cells to stresses imposed by hydrogen peroxide or high salt concentration. A plasmid containing the cloned wild-type rpoS gene restored pyrrolnitrin production and stress tolerance to the RpoS- mutant of Pf-5. The RpoS- mutant overproduced pyoluteorin and 2,4-diacetyl-phloroglucinol, two antibiotics that inhibit growth of the phytopathogenic fungus Pythium ultimum, and was superior to the wild type in suppression of seedling damping-off of cucumber caused by Pythium ultimum. When inoculated onto cucumber seed at high cell densities, the RpoS- mutant did not survive as well as the wild-type strain on surfaces of developing seedlings. Other stationary-phase-specific phenotypes of Pf-5, such as the production of cyanide and extracellular protease(s) were expressed by the RpoS- mutant, suggesting that sigma s is only one of the sigma factors required for the transcription of genes in stationary-phase cells of P. fluorescens. These results indicate that a sigma factor encoded by rpoS influences antibiotic production, biological control activity, and survival of P. fluorescens on plant surfaces. PMID:8618880

  2. Evaluation of Critical Success Factors For Successful Six Sigma Implementation in Indian Medium Scale Automotive Enterprises

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    Rajeshkumar U. Sambhe,

    2011-03-01

    Full Text Available Large scale organisations are expecting high quality products from their suppliers those are owners of SMEs’. In today scenario, many Indian SMEs’ operate their processes at the two to three sigma quality levels. So there is Six Sigma implementation needs and have been attracting much attention. Consequently, a good design ethodology for implementation of Six Sigma in manufacturing products as well as that of services is needed. The purpose of this paper is to propose and evaluation of critical success factors for successful Six Sigma implementation in medium scale automotive industries in India. The proposed method centers on critical success factors which enables the industries in the initial stage to focus on those factors which needs more concentration and it supports for successful mplementation without investing on expensive consultation

  3. Heme Utilization in Bordetella avium Is Regulated by RhuI, a Heme-Responsive Extracytoplasmic Function Sigma Factor

    Science.gov (United States)

    Kirby, Amy E.; Metzger, Daniel J.; Murphy, Erin R.; Connell, Terry D.

    2001-01-01

    Efficient utilization of heme as an iron (Fe) source by Bordetella avium requires bhuR, an Fe-regulated gene which encodes an outer membrane heme receptor. Upstream of bhuR is a 507-bp open reading frame, hereby designated rhuI (for regulator of heme uptake), which codes for a 19-kDa polypeptide. Whereas the 19-kDa polypeptide had homology to a subfamily of alternative sigma factors known as the extracytoplasmic function (ECF) sigma factors, it was hypothesized that rhuI encoded a potential in-trans regulator of the heme receptor gene in trans. Support for the model was strengthened by the identification of nucleotide sequences common to ECF sigma-dependent promoters in the region immediately upstream of bhuR. Experimental evidence for the regulatory activities of rhuI was first revealed by recombinant experiments in which overproduction of rhuI was correlated with a dramatically increased expression of BhuR. A putative rhuI-dependent bhuR promoter was identified in the 199-bp region located proximal to bhuR. When a transcriptional fusion of the 199-bp region and a promoterless lacZ gene was introduced into Escherichia coli, promoter activity was evident, but only when rhuI was coexpressed in the cell. Sigma competition experiments in E. coli demonstrated that rhuI conferred biological properties on the cell that were consistent with RhuI having sigma factor activity. Heme, hemoglobin, and several other heme-containing proteins were shown to be the extracellular inducers of the rhuI-dependent regulatory system. Fur titration assays indicated that expression of rhuI was probably Fur dependent. PMID:11598070

  4. Sigma factors, asymmetry, and the determination of cell fate in Bacillus subtilis.

    OpenAIRE

    Lewis, P J; Partridge, S R; Errington, J

    1994-01-01

    Soon after the initiation of sporulation, Bacillus subtilis divides asymmetrically to produce sister cells that have very different developmental fates. Recently, it has been proposed that the differential gene expression which begins soon after this division is due to cell-specific activation of the transcription factors sigma F and sigma E in the prespore and the mother cell, respectively. We describe the use of a method for the localization of gene expression in individual sporulating cell...

  5. Analysis of the strong coupling form factors of $\\Sigma_bNB$ and $\\Sigma_c ND$ in QCD sum rules

    CERN Document Server

    Yu, Guo Liang; Li, Zhen Yu

    2016-01-01

    In this article, we study the strong interaction of the vertexes $\\Sigma_bNB$ and $\\Sigma_c ND$ using the three-point QCD sum rules under two different dirac structures. Considering the contributions of the vacuum condensates up to dimension $5$ in the operation product expansion, the form factors of these vertexes are calculated. Then, we fit the form factors into analytical functions and extrapolate them into time-like regions, which giving the coupling constant. Our analysis indicates that the coupling constant for these two vertexes are $G_{\\Sigma_bNB}=0.43\\pm0.01GeV^{-1}$ and $G_{\\Sigma_cND}=3.76\\pm0.05GeV^{-1}$.

  6. Arabidopsis sigma factor binding proteins are activators of the WRKY33 transcription factor in plant defense.

    Science.gov (United States)

    Lai, Zhibing; Li, Ying; Wang, Fei; Cheng, Yuan; Fan, Baofang; Yu, Jing-Quan; Chen, Zhixiang

    2011-10-01

    Necrotrophic pathogens are important plant pathogens that cause many devastating plant diseases. Despite their impact, our understanding of the plant defense response to necrotrophic pathogens is limited. The WRKY33 transcription factor is important for plant resistance to necrotrophic pathogens; therefore, elucidation of its functions will enhance our understanding of plant immunity to necrotrophic pathogens. Here, we report the identification of two WRKY33-interacting proteins, nuclear-encoded SIGMA FACTOR BINDING PROTEIN1 (SIB1) and SIB2, which also interact with plastid-encoded plastid RNA polymerase SIGMA FACTOR1. Both SIB1 and SIB2 contain an N-terminal chloroplast targeting signal and a putative nuclear localization signal, suggesting that they are dual targeted. Bimolecular fluorescence complementation indicates that WRKY33 interacts with SIBs in the nucleus of plant cells. Both SIB1 and SIB2 contain a short VQ motif that is important for interaction with WRKY33. The two VQ motif-containing proteins recognize the C-terminal WRKY domain and stimulate the DNA binding activity of WRKY33. Like WRKY33, both SIB1 and SIB2 are rapidly and strongly induced by the necrotrophic pathogen Botrytis cinerea. Resistance to B. cinerea is compromised in the sib1 and sib2 mutants but enhanced in SIB1-overexpressing transgenic plants. These results suggest that dual-targeted SIB1 and SIB2 function as activators of WRKY33 in plant defense against necrotrophic pathogens.

  7. Conserved and Variable Functions of the sigma(E Stress Response in Related Genomes.

    Directory of Open Access Journals (Sweden)

    2005-12-01

    Full Text Available Bacteria often cope with environmental stress by inducing alternative sigma (sigma factors, which direct RNA polymerase to specific promoters, thereby inducing a set of genes called a regulon to combat the stress. To understand the conserved and organism-specific functions of each sigma, it is necessary to be able to predict their promoters, so that their regulons can be followed across species. However, the variability of promoter sequences and motif spacing makes their prediction difficult. We developed and validated an accurate promoter prediction model for Escherichia coli sigma(E, which enabled us to predict a total of 89 unique sigma(E-controlled transcription units in E. coli K-12 and eight related genomes. sigma(E controls the envelope stress response in E. coli K-12. The portion of the regulon conserved across genomes is functionally coherent, ensuring the synthesis, assembly, and homeostasis of lipopolysaccharide and outer membrane porins, the key constituents of the outer membrane of Gram-negative bacteria. The larger variable portion is predicted to perform pathogenesis-associated functions, suggesting that sigma(E provides organism-specific functions necessary for optimal host interaction. The success of our promoter prediction model for sigma(E suggests that it will be applicable for the prediction of promoter elements for many alternative sigma factors.

  8. Whole-genome phylogenies of the family Bacillaceae and expansion of the sigma factor gene family in the Bacillus cereus species-group

    Directory of Open Access Journals (Sweden)

    Dyer David W

    2011-08-01

    appears to have preferentially occurred within the extracytoplasmic function (ECF sigma factor genes, while the primary alternative (PA sigma factor genes are, in general, highly conserved with those found in B. subtilis. Divergence of the sigma-controlled transcriptional regulons among various members of the Bc species-group likely has a major role in explaining the diversity of phenotypic characteristics seen in members of the Bc species-group.

  9. Critical success factors in the implementation of six sigma program: a systematic review of quantitative research

    Directory of Open Access Journals (Sweden)

    Daniela Santana Lambert Marzagão

    2014-05-01

    Full Text Available The aim of this paper is to review the literature on Six Sigma, identifying critical success factors. For this, the authors developed a theoretical framework to assist the statistical analysis. We searched articles in ISI Web of Knowledge, using the words "Six Sigma" and "Quality" in the period between 1988 and 2010. Of the 270 jobs generated in the search, type a search addressed 11 Survey with similarity of issues. A meta-analysis was performed in 6 of these 11 articles, which were available at no cost. The results showed that very few quantitative studies were performed. From a statistical viewpoint, the main limitations were the sample size and choice of appropriate tools. The four critical success factors that could be compared were: quality culture, employee involvement, project selection and training and learning. A difference found between Six Sigma and other quality initiatives is the integration with the Portfolio Management.

  10. First Measurement of Form Factors of the Decay Xi0->Sigma+ e- anti-nu/e

    CERN Document Server

    Alavi-Harati, A; Arenton, M; Arisaka, K; Averitte, S; Barbosa, R F; Barker, A R; Barrio, M; Bellantoni, L; Bellavance, A; Belz, J E; Ben-David, R; Bergman, D R; Blucher, E; Bock, G J; Bown, C; Bright, S T; Cheu, E; Childress, S; Coleman, R; Corcoran, M D; Corti, G; Cox, B; Crisler, M B; Erwin, A R; Ford, R; Glazov, A; Golossanov, A; Graham, G; Graham, J; Hagan, K; Halkiadakis, E; Hamm, J; Hanagaki, K; Hidaka, S; Hsiung, Y B; Jejer, V; Jensen, D A; Kessler, R; Kobrak, H G E; La Due, J; Lath, A; Ledovskoy, A A; McBride, P; Mikelsons, P; Monnier, E; Nakaya, T; Nelson, K S; Nguyen, H; O'Dell, Vivian; Pang, M; Pordes, R; Prasad, V; Qi, X R; Quinn, B; Ramberg, E J; Ray, R E; Roodman, A; Sadamoto, M; Schnetzer, S; Senyo, K; Shanahan, P; Shawhan, P S; Shields, J; Slater, W; Solomey, Nickolas; Somalwar, S V; Stone, R L; Swallow, E C; Taegar, S A; Tesarek, R J; Thomson, G B; Toale, P A; Tripathi, A K; Tschirhart, R S; Turner, S E; Wah, Y W; Wang, J; White, H B; Whitmore, J; Winstein, Bruce D; Winston, R; Yamanaka, T; Zimmerman, E D

    2001-01-01

    We present the first measurement of the form factor ratios g1/f1 (direct axial-vector to vector), g2/f1 (second class current) and f2/f1 (weak magnetism) for the decay Xi0 -> Sigma+ e- anti-nu/e using the KTeV (E799) beam line and detector at Fermilab. From the Sigma+ polarization measured with the decay Sigma+ -> p pi0 and the e- - anti-nu/e correlation, we measure g1/f1 to be 1.32 +0.21-0.17(stat.) +/- 0.05(syst.), assuming the SU(3)f (flavor) values for g2/f1 and f2/f1. Our results are all consistent with exact SU(3)f symmetry.

  11. Studies of the extracytoplasmic function sigma factor PG0162 in Porphyromonas gingivalis.

    Science.gov (United States)

    Dou, Y; Aruni, W; Muthiah, A; Roy, F; Wang, C; Fletcher, H M

    2016-06-01

    PG0162, annotated as an extracytoplasmic function (ECF) sigma factor in Porphyromonas gingivalis, is composed of 193 amino acids. As previously reported, the PG0162-deficient mutant, P. gingivalis FLL350 showed significant reduction in gingipain activity compared with the parental strain. Because this ECF sigma factor could be involved in the virulence regulation in P. gingivalis, its genetic properties were further characterized. A 5'-RACE analysis showed that the start of transcription of the PG0162 gene occurred from a guanine (G) residue 69 nucleotides upstream of the ATG translation initiation codon. The function of PG0162 as a sigma factor was confirmed in a run-off in vitro transcription assay using the purified rPG0162 and RNAP core enzyme from Escherichia coli with the PG0162 promoter as template. As an appropriate PG0162 inducing environmental signal is unknown, a strain overexpressing the PG0162 gene designated P. gingivalis FLL391 was created. Compared with the wild-type strain, transcriptome analysis of P. gingivalis FLL391 showed that approximately 24% of the genome displayed altered gene expression (260 upregulated genes; 286 downregulated genes). Two other ECF sigma factors (PG0985 and PG1660) were upregulated more than two-fold. The autoregulation of PG0162 was confirmed with the binding of the rPG0162 protein to the PG0162 promoter in electrophoretic mobility shift assay. In addition, the rPG0162 protein also showed the ability to bind to the promoter region of two genes (PG0521 and PG1167) that were most upregulated in P. gingivalis FLL391. Taken together, our data suggest that PG0162 is a sigma factor that may play an important role in the virulence regulatory network in P. gingivalis. PMID:26216199

  12. Mapping temperature-induced conformational changes in the Escherichia coli heat shock transcription factor sigma 32 by amide hydrogen exchange

    DEFF Research Database (Denmark)

    Rist, Wolfgang; Jørgensen, Thomas J D; Roepstorff, Peter;

    2003-01-01

    Stress conditions such as heat shock alter the transcriptional profile in all organisms. In Escherichia coli the heat shock transcription factor, sigma 32, out-competes upon temperature up-shift the housekeeping sigma-factor, sigma 70, for binding to core RNA polymerase and initiates heat shock...... gene transcription. To investigate possible heat-induced conformational changes in sigma 32 we performed amide hydrogen (H/D) exchange experiments under optimal growth and heat shock conditions combined with mass spectrometry. We found a rapid exchange of around 220 of the 294 amide hydrogens at 37...

  13. A longitudinal study of the indicators and factors for successful six sigma deployment in the South African mining industry

    Directory of Open Access Journals (Sweden)

    Keeley, A. L.

    2013-05-01

    Full Text Available The Six Sigma deployment methodology is known for its results in operational excellence associated with improved business practices. Organisations worldwide have shown significantly reduced costs and increased profits when successfully deploying Six Sigma. This paper reports a longitudinal study of a set of indicators and success factors for Six Sigma deployment, using Lonmin PLC, a mining company in South Africa, as a case. The results suggest a shift of indicators from heartfelt personal involvement in 2006 to a mechanistic performance-based culture in 2010. Practical recommendations are made regarding the nine success factor components to be included during Six Sigma deployment

  14. Characterization of five ECF sigma factors in the genome of Pseudomonas syringae pv. syringae B728a.

    Directory of Open Access Journals (Sweden)

    Poulami Basu Thakur

    Full Text Available Pseudomonas syringae pv. syringae B728a, a bacterial pathogen of bean, utilizes large surface populations and extracellular signaling to initiate a fundamental change from an epiphytic to a pathogenic lifestyle. Extracytoplasmic function (ECF sigmafactors serve as important regulatory factors in responding to various environmental signals. Bioinformatic analysis of the B728a genome revealed 10 ECF sigma factors. This study analyzed deletion mutants of five previously uncharacterized ECF sigma factor genes in B728a, including three FecI-type ECF sigma factors (ECF5, ECF6, and ECF7 and two ECF sigma factors placed in groups ECF11 and ECF18. Transcriptional profiling by qRT-PCR analysis of ECF sigma factor mutants was used to measure expression of their associated anti-sigma and outer membrane receptor proteins, and expression of genes associated with production of extracellular polysaccharides, fimbriae, glycine betaine and syringomycin. Notably, the B728aΔecf7 mutant displayed reduced swarming and had decreased expression of CupC fimbrial genes. Growth and pathogenicity assays, using a susceptible bean host, revealed that none of the tested sigma factor genes are required for in planta growth and lesion formation.

  15. Genetic Transplantation: Salmonella enterica Serovar Typhimurium as a Host To Study Sigma Factor and Anti-Sigma Factor Interactions in Genetically Intractable Systems

    OpenAIRE

    Karlinsey, Joyce E.; Hughes, Kelly T.

    2006-01-01

    In Salmonella enterica serovar Typhimurium, σ28 and anti-sigma factor FlgM are regulatory proteins crucial for flagellar biogenesis and motility. In this study, we used S. enterica serovar Typhimurium as an in vivo heterologous system to study σ28 and anti-σ28 interactions in organisms where genetic manipulation poses a significant challenge due to special growth requirements. The chromosomal copy of the S. enterica serovar Typhimurium σ28 structural gene fliA was exchanged with homologs of A...

  16. Bacterial Sigma Factors as Targets for Engineered or Synthetic Transcriptional Control

    Science.gov (United States)

    Tripathi, Lakshmi; Zhang, Yan; Lin, Zhanglin

    2014-01-01

    Sigma (σ) factors are the predominant constituents of transcription regulation in bacteria. σ Factors recruit the core RNA polymerase to recognize promoters with specific DNA sequences. Recently, engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in σ factor based engineering or synthetic design. The manipulation of σ factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria. PMID:25232540

  17. Bacterial sigma factors as targets for engineered or synthetic transcriptional control

    Directory of Open Access Journals (Sweden)

    Lakshmi eTripathi

    2014-09-01

    Full Text Available Sigmafactors are the predominant constituents of transcription regulation in bacteria. σ factors recruit the core RNA polymerase (RNAP to recognize promoters with specific DNA sequences. Recently engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in σ factor based engineering or synthetic design. The manipulation of σ factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria.

  18. First Measurements of Timelike Form Factors of the Hyperons, Lambda0, Sigma0, Sigma+, Xi0, Xi-, and Omega-, and Evidence of Diquark Correlations

    CERN Document Server

    Dobbs, S; Xiao, T; Seth, Kamal K; Bonvicini, G

    2014-01-01

    Using 805 pb^-1 of e+e- annihilation data taken with the CLEO-c detector at psi(3770), sqrt{s}=3770 MeV, we report the first measurements of the electromagnetic form factors of the Lambda0, Sigma0, Sigma+, Xi0, Xi-, and Omega- hyperons for the large timelike momentum transfer of |Q^2|=14.2 GeV^2. The form factors for the different hyperons are found to vary by nearly a factor two. It is found that |G_M(Lambda0)|=1.66(24) x |G_M(Sigma0)|. The Lambda0 and Sigma0 hyperons have the same uds quark content, but differ in their isospin, and therefore the spin of the $ud$ quark pair. It is suggested that the spatial correlation implied by the singlet spin--isospin configuration in the Lambda0 is an example of strong diquark correlations in the Lambda0, as anticipated by Jaffe and Wilczek. Improved measurements of the branching fractions of psi(2S) -> p pbar and hyperon--antihyperon pairs are also reported.

  19. Importance of sigma factor mutations in increased triclosan resistance in Salmonella Typhimurium

    DEFF Research Database (Denmark)

    Gantzhorn, Mette Rørbæk; Olsen, John Elmerdahl; Thomsen, Line Elnif

    2015-01-01

    . Typhimurium 4/74 and DTU3 were adapted to increasing concentrations of the biocide triclosan by serial passage. High level triclosan resistant isolates (MIC > 1000 μg/ml) were obtained. Strains were genome sequenced, and SNPs in fabI, rpoS and rpoD were found to be associated with high level resistance....... However, work with defined mutants revealed that a SNP in fabI was not sufficient to obtain high level resistance. This required additional mutations in the sigma factors rpoS or rpoD. The adapted strains showed triclosan-dependent increased efflux, increased fabI expression and reduced susceptibility...... towards the antibiotics enrofloxacin and sulphamethoxazole/trimethoprim. CONCLUSIONS: Medium level triclosan resistance could be obtained by fabI mutations in S. Typhimurium, however, high level resistance was found to require sigma factor mutations in addition to a fabI mutation. Reduced antibiotic...

  20. Critical Success Factors of Six Sigma in Original Equipment Manufacturer Company in Malaysia

    OpenAIRE

    Tack-Wei Leong; Pei-Lee Teh

    2012-01-01

    Purpose – This paper aims to examine the five critical success factors (i.e., top management involvement and commitment, training and education, teamwork, cultural change, and organizational infrastructure) on Six Sigma implementation in the Original Equipment Manufacturer (OEM) industry. Design/methodology/approach – Survey data are collected from 102 employees from a renowned OEM company in Malaysia. Multiple regression analysis is performed to test the research hypothesis. Findings – The r...

  1. A role for sigma factor SigE in Corynebacterium pseudotuberculosis resistance to nitric oxide/ peroxide stress

    Directory of Open Access Journals (Sweden)

    Luis G. C. Pacheco

    2012-04-01

    Full Text Available Pathogenic intracellular bacteria can respond to antimicrobial mechanisms of the host cell through transient activation of stress-responsive genes by alternative sigmafactors of the RNA polymerase. We evaluated the contribution of the extracytoplasmic function sigma factor σE for Corynebacterium pseudotuberculosis resistance to stress conditions resembling those found intracellularly during infection. A sigE null mutant strain (delta-sigE of this bacterium was more susceptible in vitro to acidic pH, cell surface stressors, and biologically relevant concentrations of nitric oxide (NO. The same mutant strain was unable to persist in C57BL/6 mice but remained infective in mice lacking inducible nitric oxide synthase (iNOS, confirming the significance of σE for resistance to nitric oxide/peroxide stress in vivo. High-throughput proteomic analysis identified NO-responsive extracellular proteins of C. pseudotuberculosis and demonstrated the participation of σE in composition of this bacterium´s exoproteome.

  2. An extracytoplasmic function sigma factor cotranscribed with its cognate anti-sigma factor confers tolerance to NaCl, ethanol and methylene blue in Azospirillum brasilense Sp7.

    Science.gov (United States)

    Mishra, Mukti Nath; Kumar, Santosh; Gupta, Namrata; Kaur, Simarjot; Gupta, Ankush; Tripathi, Anil K

    2011-04-01

    Azospirillum brasilense, a plant-growth-promoting rhizobacterium, is exposed to changes in its abiotic environment, including fluctuations in temperature, salinity, osmolarity, oxygen concentration and nutrient concentration, in the rhizosphere and in the soil. Since extra-cytoplasmic function (ECF) sigma factors play an important role in stress adaptation, we analysed the role of ECF sigma factor (also known as RpoE or σ(E)) in abiotic stress tolerance in A. brasilense. An in-frame rpoE deletion mutant of A. brasilense Sp7 was carotenoidless and slow-growing, and was sensitive to salt, ethanol and methylene blue stress. Expression of rpoE in the rpoE deletion mutant complemented the defects in growth, carotenoid biosynthesis and sensitivity to different stresses. Based on data from reverse transcriptase-PCR, a two-hybrid assay and a pull-down assay, we present evidence that rpoE is cotranscribed with chrR and the proteins synthesized from these two overlapping genes interact with each other. Identification of the transcription start site by 5' rapid amplification of cDNA ends showed that the rpoE-chrR operon was transcribed by two promoters. The proximal promoter was less active than the distal promoter, whose consensus sequence was characteristic of RpoE-dependent promoters found in alphaproteobacteria. Whereas the proximal promoter was RpoE-independent and constitutively expressed, the distal promoter was RpoE-dependent and strongly induced in response to stationary phase and elevated levels of ethanol, salt, heat and methylene blue. This study shows the involvement of RpoE in controlling carotenoid synthesis as well as in tolerance to some abiotic stresses in A. brasilense, which might be critical in the adaptation, survival and proliferation of this rhizobacterium in the soil and rhizosphere under stressful conditions.

  3. Sigma factor RpoN (σ54) regulates pilE transcription in commensal Neisseria elongata.

    Science.gov (United States)

    Rendón, María A; Hockenberry, Alyson M; McManus, Steven A; So, Magdalene

    2013-10-01

    Human-adapted Neisseria includes two pathogens, Neisseria gonorrhoeae and Neisseria meningitidis, and at least 13 species of commensals that colonize many of the same niches as the pathogens. The Type IV pilus plays an important role in the biology of pathogenic Neisseria. In these species, Sigma factor RpoD (σ(70)), Integration Host Factor, and repressors RegF and CrgA regulate transcription of pilE, the gene encoding the pilus structural subunit. The Type IV pilus is also a strictly conserved trait in commensal Neisseria. We present evidence that a different mechanism regulates pilE transcription in commensals. Using Neisseria elongata as a model, we show that Sigma factor RpoN (σ(54)), Integration Host Factor, and an activator we name Npa regulate pilE transcription. Taken in context with previous reports, our findings indicate pilE regulation switched from an RpoN- to an RpoD-dependent mechanism as pathogenic Neisseria diverged from commensals during evolution. Our findings have implications for the timing of Tfp expression and Tfp-mediated host cell interactions in these two groups of bacteria. PMID:23899162

  4. Multiple sigma factor genes in Brevibacterium lactofermentum: characterization of sigA and sigB.

    OpenAIRE

    Oguiza, J A; Marcos, A T; Malumbres, M; Martín, J F

    1996-01-01

    Four rpoD hybridizing signals have been identified in the chromosome of Brevibacterium lactofermentum. Two rpoD-like genes, sigA and sigB, have been cloned and sequenced, and they encode principal sigma factors of the RNA polymerase. The deduced amino acid sequences of SigA and SigB showed very high similarities to those of Mycobacterium smegmatis MysA and MysB proteins, respectively, and also to those of HrdB proteins from different Streptomyces species. SigA and SigB maintain the conserved ...

  5. SpoIIE governs the phosphorylation state of a protein regulating transcription factor sigma F during sporulation in Bacillus subtilis.

    OpenAIRE

    Arigoni, F.; Duncan, L; Alper, S; Losick, R; Stragier, P

    1996-01-01

    Cell-specific activation of the transcription factor sigma F during sporulation in Bacillus subtilis is controlled by a regulatory pathway involving the proteins SpoIIE, SpoIIAA, and SpoIIAB. SpoIIAB is an antagonist of sigma F, and SpoIIAA, which is capable of overcoming SpoIIAB-mediated inhibition of sigma F, is an antagonist of SpoIIAB. SpoIIAA is, in turn, negatively regulated by SpoIIAB, which phosphorylates SpoIIAA on serine 58. SpoIIAA is also positively regulated by SpoIIE, which deph...

  6. A two-component system, an anti-sigma factor and two paralogous ECF sigma factors are involved in the control of general stress response in Caulobacter crescentus.

    Science.gov (United States)

    Lourenço, Rogério F; Kohler, Christian; Gomes, Suely L

    2011-06-01

    The extracytoplasmic function sigma factor σ(T) is the master regulator of general stress response in Caulobacter crescentus and controls the expression of its paralogue σ(U). In this work we showed that PhyR and NepR act, respectively, as positive and negative regulators of σ(T) expression and function. Biochemical data also demonstrated that NepR directly binds σ(T) and the phosphorylated form of PhyR. We also described the essential role of the histidine kinase gene CC3474, here denominated phyK, for expression of σ(T)-dependent genes and for resistance to stress conditions. Additionally, in vivo evidence of PhyK-dependent phosphorylation of PhyR is presented. This study also identified a conserved cysteine residue (C95) located in the periplasmic portion of PhyK that is crucial for the function of the protein. Furthermore, we showed that PhyK, PhyR and σ(T) regulate the same set of genes and that σ(T) apparently directly controls most of its regulon. In contrast, σ(U) seems to have a very modest contribution to the expression of a subset of σ(T)-dependent genes. In conclusion, this report describes the molecular mechanism involved in the control of general stress response in C. crescentus.

  7. RpoS (Sigma-S) Controls Expression of rsmA, a Global Regulator of Secondary Metabolites, Harpin, and Extracellular Proteins in Erwinia carotovora†

    OpenAIRE

    Mukherjee, Asita; Cui, Yaya; Ma, Weilei; Liu, Yang; Ishihama, Akira; Eisenstark, Abraham; Chatterjee, Arun K.

    1998-01-01

    RpoS (sigma-S or sigma-38) controls a large array of genes that are expressed during stationary phase and under various stress conditions in Escherichia coli and other bacteria. We document here that plant pathogenic and epiphytic Erwinia species, such as E. amylovora; E. carotovora subsp. atroseptica, betavasculorum, and carotovora; E. chrysanthemi; E. herbicola; E. rhapontici; and E. stewartii, possess rpoS genes and produce the alternate sigma factor. We show that rpoS transcription in E. ...

  8. Efficient cell-free expression with the endogenous E. Coli RNA polymerase and sigma factor 70

    Directory of Open Access Journals (Sweden)

    Noireaux Vincent

    2010-06-01

    Full Text Available Abstract Background Escherichia coli cell-free expression systems use bacteriophage RNA polymerases, such as T7, to synthesize large amounts of recombinant proteins. These systems are used for many applications in biotechnology, such as proteomics. Recently, informational processes have been reconstituted in vitro with cell-free systems. These synthetic approaches, however, have been seriously limited by a lack of transcription modularity. The current available cell-free systems have been optimized to work with bacteriophage RNA polymerases, which put significant restrictions to engineer processes related to biological information. The development of efficient cell-free systems with broader transcription capabilities is required to study complex informational processes in vitro. Results In this work, an efficient cell-free expression system that uses the endogenous E. coli RNA polymerase only and sigma factor 70 for transcription was prepared. Approximately 0.75 mg/ml of Firefly luciferase and enhanced green fluorescent protein were produced in batch mode. A plasmid was optimized with different regulatory parts to increase the expression. In addition, a new eGFP was engineered that is more translatable in cell-free systems than the original eGFP. The protein production was characterized with three different adenosine triphosphate (ATP regeneration systems: creatine phosphate (CP, phosphoenolpyruvate (PEP, and 3-phosphoglyceric acid (3-PGA. The maximum protein production was obtained with 3-PGA. Preparation of the crude extract was streamlined to a simple routine procedure that takes 12 hours including cell culture. Conclusions Although it uses the endogenous E. coli transcription machinery, this cell-free system can produce active proteins in quantities comparable to bacteriophage systems. The E. coli transcription provides much more possibilities to engineer informational processes in vitro. Many E. coli promoters/operators specific to sigma

  9. Evaluation of Critical Success Factors For Successful Six Sigma Implementation in Indian Medium Scale Automotive Enterprises

    OpenAIRE

    Rajeshkumar U. Sambhe,; Dr. Rajendra S. Dalu

    2011-01-01

    Large scale organisations are expecting high quality products from their suppliers those are owners of SMEs’. In today scenario, many Indian SMEs’ operate their processes at the two to three sigma quality levels. So there is Six Sigma implementation needs and have been attracting much attention. Consequently, a good design ethodology for implementation of Six Sigma in manufacturing products as well as that of services is needed. The purpose of this paper is to propose and evaluation of criti...

  10. Novel sigmaB regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases.

    NARCIS (Netherlands)

    Been, M.W.H.J. de; Francke, C.; Siezen, R.J.; Abee, T.

    2011-01-01

    A common bacterial strategy to cope with stressful conditions is the activation of alternative sigma factors that control specific regulons enabling targeted responses. In the human pathogen Bacillus cereus, activation of the major stress-responsive sigma factor sigma(B) is controlled by a signallin

  11. The Road Towards Lean Six Sigma: Sustainable Success Factors in Service Industry

    Directory of Open Access Journals (Sweden)

    Vouzas Fotis

    2014-11-01

    Full Text Available It has been widely investigated that the application of operations management techniques is not only based on technical factors, but it is mainly associated with organisational factors such as culture, previous polices and procedures, etc. A prime example of promisng operations practices is Lean Six Sigma (L6σ. The main research question for L6σ is related to its liabilities and constrains regarding its implementation. Therefore, this paper aims to explore the critical factors related to the application L6σ. The context of the analysis is service industry since it seems that it has been neglected from the literature that mainly focuses on manufacturing. The methodology was based on the qualitative exploration of three case studies from the service industry. Secondary data were collected through an analysis of companies' documents, written procedures and quality assurance policies and primary data were collected through a number of in-depth face-to-face interviews with managers and quality experts. The findings show that there are ten (10 particular factors that influence the implementation of L6σ in service organizations.

  12. Functional analysis of PSPTO_1203 a FecI-like ECF Sigma Factor of Pseudomonas syringae pv. tomato DC3000

    Science.gov (United States)

    We have been investigating how P. syringae responds to limited iron availability, a common stress in aerobic environments. We are mainly focused on the role of the extracytoplasmic function (ECF) sigma factors, which are one of the mechanisms used by bacteria to adjust gene regulation in response to...

  13. Transcriptional regulation of the operon encoding stress-responsive ECF sigma factor SigH and its anti-sigma factor RshA, and control of its regulatory network in Corynebacterium glutamicum

    Directory of Open Access Journals (Sweden)

    Busche Tobias

    2012-09-01

    Full Text Available Abstract Background The expression of genes in Corynebacterium glutamicum, a Gram-positive non-pathogenic bacterium used mainly for the industrial production of amino acids, is regulated by seven different sigma factors of RNA polymerase, including the stress-responsive ECF-sigma factor SigH. The sigH gene is located in a gene cluster together with the rshA gene, putatively encoding an anti-sigma factor. The aim of this study was to analyze the transcriptional regulation of the sigH and rshA gene cluster and the effects of RshA on the SigH regulon, in order to refine the model describing the role of SigH and RshA during stress response. Results Transcription analyses revealed that the sigH gene and rshA gene are cotranscribed from four sigH housekeeping promoters in C. glutamicum. In addition, a SigH-controlled rshA promoter was found to only drive the transcription of the rshA gene. To test the role of the putative anti-sigma factor gene rshA under normal growth conditions, a C. glutamicum rshA deletion strain was constructed and used for genome-wide transcription profiling with DNA microarrays. In total, 83 genes organized in 61 putative transcriptional units, including those previously detected using sigH mutant strains, exhibited increased transcript levels in the rshA deletion mutant compared to its parental strain. The genes encoding proteins related to disulphide stress response, heat stress proteins, components of the SOS-response to DNA damage and proteasome components were the most markedly upregulated gene groups. Altogether six SigH-dependent promoters upstream of the identified genes were determined by primer extension and a refined consensus promoter consisting of 45 original promoter sequences was constructed. Conclusions The rshA gene codes for an anti-sigma factor controlling the function of the stress-responsive sigma factor SigH in C. glutamicum. Transcription of rshA from a SigH-dependent promoter may serve to quickly

  14. Enhanced Promoter Activity by Replenishment of Sigma Factor rpoE in Klebsiella pneumoniae.

    Science.gov (United States)

    Chen, Liuni; Li, Ying; Tian, Pingfang

    2016-06-01

    Plasmid-dependent overexpression of enzyme(s) aims to divert carbon flux toward a desired compound. One drawback of this strategy is compromise of growth due to massive consumption of host resources. Here we show that replenishment of sigma factor rpoE improves the growth of Klebsiella pneumoniae. The gene rpoE was expressed alone or coexpressed with Ald4 (an aldehyde dehydrogenase from Saccharomyces cerevisiae) in K. pneumoniae. We found that the Ald4 activity was higher in the strain coexpressing Ald4 and rpoE (32.3 U/mg) than that expressing Ald4 alone (29.9 U/mg). Additionally, under shake-flask conditions, the strain coexpressing Ald4 and rpoE produced 0.5 g 3-hydroxypropionic acid (3-HP) and 9.8 g 1,3-propanediol (1,3-PD) per liter in 24 h, which were 1.6- and 0.85-fold enhancement, respectively, compared to those expressing Ald4 alone. Notably, under non-optimized bioreactor conditions, the strain coexpressing Ald4 and rpoE produced 13.5 g 3-HP and 37.8 g 1,3-PD per liter with glycerol conversion ratio of 0.45 mol/mol. These results indicate that replenishment of rpoE enhanced promoter activity and stimulated glycerol consumption. PMID:27570311

  15. Improving furfural tolerance of Zymomonas mobilis by rewiring a sigma factor RpoD protein.

    Science.gov (United States)

    Tan, Fu-Rong; Dai, Li-Chun; Wu, Bo; Qin, Han; Shui, Zong-Xia; Wang, Jing-Li; Zhu, Qi-Li; Hu, Qi-Chun; Ruan, Zhi-Yong; He, Ming-Xiong

    2015-06-01

    Furfural from lignocellulosic hydrolysates is the key inhibitor for bio-ethanol fermentation. In this study, we report a strategy of improving the furfural tolerance in Zymomonas mobilis on the transcriptional level by engineering its global transcription sigma factor (σ(70), RpoD) protein. Three furfural tolerance RpoD mutants (ZM4-MF1, ZM4-MF2, and ZM4-MF3) were identified from error-prone PCR libraries. The best furfural-tolerance strain ZM4-MF2 reached to the maximal cell density (OD600) about 2.0 after approximately 30 h, while control strain ZM4-rpoD reached its highest cell density of about 1.3 under the same conditions. ZM4-MF2 also consumed glucose faster and yield higher ethanol; expression levels and key Entner-Doudoroff (ED) pathway enzymatic activities were also compared to control strain under furfural stress condition. Our results suggest that global transcription machinery engineering could potentially be used to improve stress tolerance and ethanol production in Z. mobilis.

  16. Identification of sigmaB-dependent genes in Bacillus cereus by proteome and in vitro transcription analysis

    NARCIS (Netherlands)

    Schaik, van W.; Zwietering, M.H.; Vos, de W.M.; Abee, T.

    2004-01-01

    The alternative sigma factor sigma(B) of the food pathogen Bacillus cereus is activated upon stress exposure and plays a role in the adaptive response of vegetative cells. This study describes the identification of sigma(B)-dependent genes in B. cereus. Two-dimensional gel electrophoresis was perfor

  17. Identification of metabolism pathways directly regulated by Sigma54 factor in Bacillus thuringiensis

    Directory of Open Access Journals (Sweden)

    Qi ePeng

    2015-05-01

    Full Text Available Sigma54 (σ54 normally regulates nitrogen and carbon utilization in bacteria. Promoters that are σ54-dependent are highly conserved and contain short sequences located at the −24 and −12 positions upstream of the transcription initiation site. σ54 requires regulatory proteins known as bacterial enhancer-binding proteins (bEBPs to activate gene transcription. We show that σ54 regulates the capacity to grow on various nitrogen sources using a Bacillus thuringiensis HD73 mutant lacking the sigL gene encoding σ54 (ΔsigL. A 2-fold-change cutoff and a false discovery rate cutoff of P < 0.05 were used to analyze the DNA microarray data, which revealed 255 genes that were downregulated and 121 that were upregulated in the ΔsigL mutant relative to the wild-type HD73 strain. The σ54 regulon (stationary phase was characterized by DNA microarray, bioinformatics, and functional assay; 16 operons containing 47 genes were identified whose promoter regions contain the conserved −12/−24 element and whose transcriptional activities were abolished or reduced in the ΔsigL mutant. Eight σ54-dependent transcriptional bEBPs were found in the Bt HD73 genome, and they regulated night σ54-dependent promoters.The metabolic pathways activated by σ54 in this process have yet to be identified in Bacillus thuringiensis; nonetheless, the present analysis of the σ54 regulon provides a better understanding of the physiological roles of σ factors in bacteria.

  18. Region 4 of Rhizobium etli Primary Sigma Factor (SigA) Confers Transcriptional Laxity in Escherichia coli

    Science.gov (United States)

    Santillán, Orlando; Ramírez-Romero, Miguel A.; Lozano, Luis; Checa, Alberto; Encarnación, Sergio M.; Dávila, Guillermo

    2016-01-01

    Sigma factors are RNA polymerase subunits engaged in promoter recognition and DNA strand separation during transcription initiation in bacteria. Primary sigma factors are responsible for the expression of housekeeping genes and are essential for survival. RpoD, the primary sigma factor of Escherichia coli, a γ-proteobacteria, recognizes consensus promoter sequences highly similar to those of some α-proteobacteria species. Despite this resemblance, RpoD is unable to sustain transcription from most of the α-proteobacterial promoters tested so far. In contrast, we have found that SigA, the primary sigma factor of Rhizobium etli, an α-proteobacteria, is able to transcribe E. coli promoters, although it exhibits only 48% identity (98% coverage) to RpoD. We have called this the transcriptional laxity phenomenon. Here, we show that SigA partially complements the thermo-sensitive deficiency of RpoD285 from E. coli strain UQ285 and that the SigA region σ4 is responsible for this phenotype. Sixteen out of 74 residues (21.6%) within region σ4 are variable between RpoD and SigA. Mutating these residues significantly improves SigA ability to complement E. coli UQ285. Only six of these residues fall into positions already known to interact with promoter DNA and to comprise a helix-turn-helix motif. The remaining variable positions are located on previously unexplored sites inside region σ4, specifically into the first two α-helices of the region. Neither of the variable positions confined to these helices seem to interact directly with promoter sequence; instead, we adduce that these residues participate allosterically by contributing to correct region folding and/or positioning of the HTH motif. We propose that transcriptional laxity is a mechanism for ensuring transcription in spite of naturally occurring mutations from endogenous promoters and/or horizontally transferred DNA sequences, allowing survival and fast environmental adaptation of α-proteobacteria. PMID

  19. Six Sigma and Implementations of Six Sigma in Finance Sector

    OpenAIRE

    Gokhan Senol; Adem Anbar

    2010-01-01

    Quality is a one of the critical factors for achieving competitive advantage. Six sigma approach is a business strategy which usage has increased gradually in last years for quality improvement initiative. Although six sigma established by a manufacturing firm and it has been successfully implemented in many manufacturing firms, service firms have began to use six sigma for reducing cost, enhanced quality of service, increasing customer satisfaction and profitability. In this paper, six sigma...

  20. Regulation of sigma S degradation in Salmonella enterica var typhimurium: in vivo interactions between sigma S, the response regulator MviA(RssB) and ClpX.

    Science.gov (United States)

    Moreno, M; Audia, J P; Bearson, S M; Webb, C; Foster, J W

    2000-04-01

    The alternate sigma factor sigmaS plays an important role in the survival of Salmonella typhimurium following sudden encounters with a variety of stress conditions. The level of sigmaS is very low in rapidly growing cells but dramatically increases as those cells encounter environmental stress or enter into stationary phase. This increase is due in large measure to the stabilization of sigmaS protein against degradation by the ClpXP protease. The MviA protein, also known as RssB or SprE in Escherichia coli, is a putative member of a two component signal transduction system that plays a central role in facilitating sigmaS degradation by ClpXP. In contrast to most two-component systems, MviA does not appear to regulate gene expression but is believed to interact directly with sigmaS and somehow facilitate degradation. We now provide evidence that MviA(RssB) directly interacts both with sigmaS and ClpX in vivo, presumably enabling presentation of sigmaS to the ClpP protease. Interactions were demonstrated using a bacterial two-hybrid system in which sigmaS, MviA, and ClpX were fused to separate moieties of Bordetella pertussis CyaA (adenylate cyclase). Paired hybrid plasmids containing Cya'-MviA/RpoS-'Cya or Cya'-MviA/ClpX-'Cya successfully reconstituted adenylate cyclase activity in both S. typhimurium and E. coli. However, no direct interactions were detected between ClpX and RpoS. A second series of experiments has indicated that the interaction between MviA and sigmaS requires the N-terminus but not the C-terminus of MviA. Cellular levels of MviA appear to be very low in the cell based on lacZ fusion, Western blot and Northern blot analyses suggesting a catalytic role for MviA in sigmaS degradation. Mutagenesis of MviA residue D58, a canonical residue subject to phosphorylation in many two-component systems, decreased the ability of MviA to facilitate sigmaS turnover in vivo confirming that phosphorylation of MviA increases MviA activity. PMID:10939250

  1. Six Sigma and Implementations of Six Sigma in Finance Sector

    Directory of Open Access Journals (Sweden)

    Gokhan Senol

    2010-04-01

    Full Text Available Quality is a one of the critical factors for achieving competitive advantage. Six sigma approach is a business strategy which usage has increased gradually in last years for quality improvement initiative. Although six sigma established by a manufacturing firm and it has been successfully implemented in many manufacturing firms, service firms have began to use six sigma for reducing cost, enhanced quality of service, increasing customer satisfaction and profitability. In this paper, six sigma was examined in a view of finance sector and applications of six sigma within the finance sector were evaluated.

  2. Extracytoplasmic function (ECF sigma factor σF is involved in Caulobacter crescentus response to heavy metal stress

    Directory of Open Access Journals (Sweden)

    Kohler Christian

    2012-09-01

    Full Text Available Abstract Background The α-proteobacterium Caulobacter crescentus inhabits low-nutrient environments and can tolerate certain levels of heavy metals in these sites. It has been reported that C. crescentus responds to exposure to various heavy metals by altering the expression of a large number of genes. Results In this work, we show that the ECF sigma factor σF is one of the regulatory proteins involved in the control of the transcriptional response to chromium and cadmium. Microarray experiments indicate that σF controls eight genes during chromium stress, most of which were previously described as induced by heavy metals. Surprisingly, σF itself is not strongly auto-regulated under metal stress conditions. Interestingly, σF-dependent genes are not induced in the presence of agents that generate reactive oxygen species. Promoter analyses revealed that a conserved σF-dependent sequence is located upstream of all genes of the σF regulon. In addition, we show that the second gene in the sigF operon acts as a negative regulator of σF function, and the encoded protein has been named NrsF (Negative regulator of sigma F. Substitution of two conserved cysteine residues (C131 and C181 in NrsF affects its ability to maintain the expression of σF-dependent genes at basal levels. Furthermore, we show that σF is released into the cytoplasm during chromium stress and in cells carrying point mutations in both conserved cysteines of the protein NrsF. Conclusion A possible mechanism for induction of the σF-dependent genes by chromium and cadmium is the inactivation of the putative anti-sigma factor NrsF, leading to the release of σF to bind RNA polymerase core and drive transcription of its regulon.

  3. Impact of different group 2 sigma factors on light use efficiency and high salt stress in the cyanobacterium Synechocystis sp. PCC 6803.

    Directory of Open Access Journals (Sweden)

    Taina Tyystjärvi

    Full Text Available Sigma factors of RNA polymerase recognize promoters and have a central role in controlling transcription initiation and acclimation to changing environmental conditions. The cyanobacterium Synechocystis sp. PCC 6803 encodes four non-essential group 2 sigma factors, SigB, SigC, SigD and SigE that closely resemble the essential SigA factor. Three out of four group 2 sigma factors were simultaneously inactivated and acclimation responses of the triple inactivation strains were studied. All triple inactivation strains grew slowly in low light, and our analysis suggests that the reason is a reduced capacity to adjust the perception of light. Simultaneous inactivation of SigB and SigD hampered growth also in high light. SigB is the most important group 2 sigma factor for salt acclimation, and elimination of all the other group 2 sigma factors slightly improved the salt tolerance of Synechocystis. Presence of only SigE allowed full salt acclimation including up-regulation of hspA and ggpS genes, but more slowly than SigB. Cells with only SigD acclimated to high salt but the acclimation processes differed from those of the control strain. Presence of only SigC prevented salt acclimation.

  4. On the sigma sigma term

    CERN Document Server

    Bruns, Peter C

    2016-01-01

    We give some estimates for the light-quark mass dependence of the pole position of the sigma ($f_{0}(500)$) resonance in the complex energy plane, with the help of a chiral Lagrangian for the resonance field and some input from hadronic models constrained by Chiral Perturbation Theory and elastic unitarity. We also speculate on the fate of the sigma resonance when the quark masses become unphysically large.

  5. Adjustable Nyquist-rate System for Single-Bit Sigma-Delta ADC with Alternative FIR Architecture

    Science.gov (United States)

    Frick, Vincent; Dadouche, Foudil; Berviller, Hervé

    2016-09-01

    This paper presents a new smart and compact system dedicated to control the output sampling frequency of an analogue-to-digital converters (ADC) based on single-bit sigma-delta (ΣΔ) modulator. This system dramatically improves the spectral analysis capabilities of power network analysers (power meters) by adjusting the ADC's sampling frequency to the input signal's fundamental frequency with a few parts per million accuracy. The trade-off between straightforwardness and performance that motivated the choice of the ADC's architecture are preliminary discussed. It particularly comes along with design considerations of an ultra-steep direct-form FIR that is optimised in terms of size and operating speed. Thanks to compact standard VHDL language description, the architecture of the proposed system is particularly suitable for application-specific integrated circuit (ASIC) implementation-oriented low-power and low-cost power meter applications. Field programmable gate array (FPGA) prototyping and experimental results validate the adjustable sampling frequency concept. They also show that the system can perform better in terms of implementation and power capabilities compared to dedicated IP resources.

  6. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways.

    Directory of Open Access Journals (Sweden)

    Tomoko Nishimura

    Full Text Available BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs have been widely used and are a major therapeutic advance in psychopharmacology. However, their pharmacology is quite heterogeneous. The SSRI fluvoxamine, with sigma-1 receptor agonism, is shown to potentiate nerve-growth factor (NGF-induced neurite outgrowth in PC 12 cells. However, the precise cellular and molecular mechanisms underlying potentiation by fluvoxamine are not fully understood. In this study, we examined the roles of cellular signaling pathways in the potentiation of NGF-induced neurite outgrowth by fluvoxamine and sigma-1 receptor agonists. METHODS AND FINDINGS: The effects of three SSRIs (fluvoxamine, sertraline, paroxetine and three sigma-1 receptor agonists (SA4503, 4-phenyl-1-(4-phenylbutyl piperidine (PPBP, and dehydroepiandrosterone (DHEA-sulfate on NGF-induced neurite outgrowth in PC12 cells were examined. Also examined were the effects of the sigma-1 receptor antagonist NE-100, inositol 1,4,5-triphosphate (IP(3 receptor antagonist, and specific inhibitors of signaling pathways in the potentiation of NGF-induced neurite outgrowth by selective sigma-1 receptor agonist SA4503. Fluvoxamine (but not sertraline or paroxetine and the sigma-1 receptor agonists SA4503, PPBP, and DHEA-sulfate significantly potentiated NGF-induced neurite outgrowth in PC12 cells in a concentration-dependent manner. The potentiation by fluvoxamine and the three sigma-1 receptor agonists was blocked by co-administration of the selective sigma-1 receptor antagonist NE-100, suggesting that sigma-1 receptors play a role in blocking the enhancement of NGF-induced neurite outgrowth. Moreover, the potentiation by SA4503 was blocked by co-administration of the IP(3 receptor antagonist xestospongin C. In addition, the specific inhibitors of phospholipase C (PLC-gamma, phosphatidylinositol 3-kinase (PI3K, p38MAPK, c-Jun N-terminal kinase (JNK, and the Ras/Raf/mitogen-activated protein kinase (MAPK

  7. Subfunctionalization of sigma factors during the evolution of land plants based on mutant analysis of liverwort (Marchantia polymorpha L.) MpSIG1.

    Science.gov (United States)

    Ueda, Minoru; Takami, Tsuneaki; Peng, Lianwei; Ishizaki, Kimitsune; Kohchi, Takayuki; Shikanai, Toshiharu; Nishimura, Yoshiki

    2013-01-01

    Sigma factor is a subunit of plastid-encoded RNA polymerase that regulates the transcription of plastid-encoded genes by recognizing a set of promoters. Sigma factors have increased in copy number and have diversified during the evolution of land plants, but details of this process remain unknown. Liverworts represent the basal group of embryophytes and are expected to retain the ancestral features of land plants. In liverwort (Marchantia polymorpha L.), we isolated and characterized a T-DNA-tagged mutant (Mpsig1) of sigma factor 1 (MpSIG1). The mutant did not show any visible phenotypes, implying that MpSIG1 function is redundant with that of other sigma factors. However, quantitative reverse-transcription polymerase chain reaction and RNA gel blot analysis revealed that genes related to photosynthesis were downregulated, resulting in the minor reduction of some protein complexes. The transcript levels of genes clustered in the petL, psaA, psbB, psbK, and psbE operons of liverwort were lower than those in the wild type, a result similar to that in the SIG1 defective mutant in rice (Oryza sativa). Overexpression analysis revealed primitive functional divergence between the SIG1 and SIG2 proteins in bryophytes, whereas these proteins still retain functional redundancy. We also discovered that the predominant sigma factor for ndhF mRNA expression has been diversified in liverwort, Arabidopsis (Arabidopsis thaliana), and rice. Our study shows the ancestral function of SIG1 and the process of functional partitioning (subfunctionalization) of sigma factors during the evolution of land plants.

  8. The Bartonella quintana Extracytoplasmic Function Sigma Factor RpoE Has a Role in Bacterial Adaptation to the Arthropod Vector Environment

    Science.gov (United States)

    Abromaitis, Stephanie

    2013-01-01

    Bartonella quintana is a vector-borne bacterial pathogen that causes fatal disease in humans. During the infectious cycle, B. quintana transitions from the hemin-restricted human bloodstream to the hemin-rich body louse vector. Because extracytoplasmic function (ECF) sigma factors often regulate adaptation to environmental changes, we hypothesized that a previously unstudied B. quintana ECF sigma factor, RpoE, is involved in the transition from the human host to the body louse vector. The genomic context of B. quintana rpoE identified it as a member of the ECF15 family of sigma factors found only in alphaproteobacteria. ECF15 sigma factors are believed to be the master regulators of the general stress response in alphaproteobacteria. In this study, we examined the B. quintana RpoE response to two stressors that are encountered in the body louse vector environment, a decreased temperature and an increased hemin concentration. We determined that the expression of rpoE is significantly upregulated at the body louse (28°C) versus the human host (37°C) temperature. rpoE expression also was upregulated when B. quintana was exposed to high hemin concentrations. In vitro and in vivo analyses demonstrated that RpoE function is regulated by a mechanism involving the anti-sigma factor NepR and the response regulator PhyR. The ΔrpoE ΔnepR mutant strain of B. quintana established that RpoE-mediated transcription is important in mediating the tolerance of B. quintana to high hemin concentrations. We present the first analysis of an ECF15 sigma factor in a vector-borne human pathogen and conclude that RpoE has a role in the adaptation of B. quintana to the hemin-rich arthropod vector environment. PMID:23564167

  9. A two-component system regulates gene expression of the type IX secretion component proteins via an ECF sigma factor.

    Science.gov (United States)

    Kadowaki, Tomoko; Yukitake, Hideharu; Naito, Mariko; Sato, Keiko; Kikuchi, Yuichiro; Kondo, Yoshio; Shoji, Mikio; Nakayama, Koji

    2016-01-01

    The periodontopathogen Porphyromonas gingivalis secretes potent pathogenic proteases, gingipains, via the type IX secretion system (T9SS). This system comprises at least 11 components; however, the regulatory mechanism of their expression has not yet been elucidated. Here, we found that the PorY (PGN_2001)-PorX (PGN_1019)-SigP (PGN_0274) cascade is involved in the regulation of T9SS. Surface plasmon resonance (SPR) analysis revealed a direct interaction between a recombinant PorY (rPorY) and a recombinant PorX (rPorX). rPorY autophosphorylated and transferred a phosphoryl group to rPorX in the presence of Mn(2+). These results demonstrate that PorX and PorY act as a response regulator and a histidine kinase, respectively, of a two component system (TCS), although they are separately encoded on the chromosome. T9SS component-encoding genes were down-regulated in a mutant deficient in a putative extracytoplasmic function (ECF) sigma factor, PGN_0274 (SigP), similar to the porX mutant. Electrophoretic gel shift assays showed that rSigP bound to the putative promoter regions of T9SS component-encoding genes. The SigP protein was lacking in the porX mutant. Co-immunoprecipitation and SPR analysis revealed the direct interaction between SigP and PorX. Together, these results indicate that the PorXY TCS regulates T9SS-mediated protein secretion via the SigP ECF sigma factor. PMID:26996145

  10. Role of the response regulator RssB in sigma recognition and initiation of sigma proteolysis in Escherichia coli.

    Science.gov (United States)

    Klauck, E; Lingnau, M; Hengge-Aronis, R

    2001-06-01

    In growing Escherichia coli cells, the master regulator of the general stress response, sigmaS (RpoS), is subject to rapid proteolysis. In response to stresses such as sudden carbon starvation, osmotic upshift or shift to acidic pH, sigmaS degradation is inhibited, sigmaS accumulates and numerous sigmaS-dependent genes with stress-protective functions are activated. sigmaS proteolysis is dependent on ClpXP protease and the response regulator RssB, whose phosphorylated form binds directly to sigmaS in vitro. Here, we show that substitutions of aspartate 58 (D58) in RssB, which result in higher sigmaS levels in vivo, produce RssB variants unable to bind sigmaS in vitro. Thus, RssB is the direct substrate recognition factor in sigmaS proteolysis, whose affinity for sigmaS depends on phosphorylation of its D58 residue. RssB does not dimerize or oligomerize upon this phosphorylation and sigmaS binding, and RssB and sigmaS exhibit a 1:1 stoichiometry in the complex. The receiver as well as the output domain of RssB are required for sigmaS binding (as shown in vivo and in vitro) and for complementation of an rssB null mutation. Thus, the N-terminal receiver domain plays an active and positive role in RssB function. Finally, we demonstrate that RssB is not co-degraded with sigmaS, i.e. RssB has a catalytic role in the initiation of sigmaS turnover. A model is presented that integrates the details of RssB-sigmaS interaction, the RssB catalytic cycle and potential stress signal input in the control of sigmaS proteolysis. PMID:11442836

  11. 6 sigma quality performance

    International Nuclear Information System (INIS)

    This deals with 6 sigma quality performance introducing company which has 6 sigma quality management, 6 sigma quality activity and customer, secret of success of 6 sigma quality management, what 6 sigma is, 6 sigma quality management propel system 5 propel steps of project like point of 6 sigma, flow of problem solution, tool for propel of project, performance of CTQ and total customer satisfaction, and quality management system and 6 sigma quality.

  12. Sinorhizobium meliloti sigma factors RpoE1 and RpoE4 are activated in stationary phase in response to sulfite.

    Directory of Open Access Journals (Sweden)

    Bénédicte Bastiat

    Full Text Available Rhizobia are soil bacteria able to establish a nitrogen-fixing symbiosis with legume plants. Both in soil and in planta, rhizobia spend non-growing periods resembling the stationary phase of in vitro-cultured bacteria. The primary objective of this work was to better characterize gene regulation in this biologically relevant growth stage in Sinorhizobium meliloti. By a tap-tag/mass spectrometry approach, we identified five sigma factors co-purifying with the RNA polymerase in stationary phase: the general stress response regulator RpoE2, the heat shock sigma factor RpoH2, and three extra-cytoplasmic function sigma factors (RpoE1, RpoE3 and RpoE4 belonging to the poorly characterized ECF26 subgroup. We then showed that RpoE1 and RpoE4 i are activated upon metabolism of sulfite-generating compounds (thiosulfate and taurine, ii display overlapping regulatory activities, iii govern a dedicated sulfite response by controlling expression of the sulfite dehydrogenase SorT, iv are activated in stationary phase, likely as a result of endogenous sulfite generation during bacterial growth. We showed that SorT is required for optimal growth of S. meliloti in the presence of sulfite, suggesting that the response governed by RpoE1 and RpoE4 may be advantageous for bacteria in stationary phase either by providing a sulfite detoxification function or by contributing to energy production through sulfite respiration. This paper therefore reports the first characterization of ECF26 sigma factors, the first description of sigma factors involved in control of sulphur metabolism, and the first indication that endogenous sulfite may act as a signal for regulation of gene expression upon entry of bacteria in stationary phase.

  13. Cloning, Identification, and Characterization of the rpoS-Like Sigma Factor rpoX from Vibrio alginolyticus

    Directory of Open Access Journals (Sweden)

    Jing-jing Zhao

    2009-01-01

    Full Text Available Vibrio alginolyticus ZJ-51 displays phase variation between opaque/rugose colonies (Op and translucent/smooth colonies (Tr. These colony variants show great differences in biofilm formation and motility. In this study, a gene encoding for an rpoS-like sigma factor, rpoX, has been cloned and characterized. The absence of rpoX did not affect colony switching rate but did decrease biofilm formation in both the Op and the Tr variants. When challenged with hydrogen peroxide, the ΔrpoX in the Op background showed a slightly higher survival rate compared with the wild type, whereas survival was decreased in the Tr background. Deletion of rpoX in the Tr background resulted in a higher ability to resist ethanol challenges and to survive hyperosmolarity challenges, and in the Op background the opposite phenotype was observed. This indicates that the rpoX gene is involved in biofilm formation and stress response but the effects are controlled by colony phase variation in V. alginolyticus.

  14. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.

    Directory of Open Access Journals (Sweden)

    Tamaki Ishima

    Full Text Available In addition to both the α1 adrenergic receptor and N-methyl-D-aspartate (NMDA receptor antagonists, ifenprodil binds to the sigma receptor subtypes 1 and 2. In this study, we examined the effects of ifenprodil on nerve growth factor (NGF-induced neurite outgrowth in PC12 cells. Ifenprodil significantly potentiated NGF-induced neurite outgrowth, in a concentration-dependent manner. In contrast, the α1 adrenergic receptor antagonist, prazosin and the NMDA receptor NR2B antagonist, Ro 25-6981 did not alter NGF-induced neurite outgrowth. Potentiation of NGF-induced neurite outgrowth mediated by ifenprodil was significantly antagonized by co-administration of the selective sigma-1 receptor antagonist, NE-100, but not the sigma-2 receptor antagonist, SM-21. Similarly, ifenprodil enhanced NGF-induced neurite outgrowth was again significantly reduced by the inositol 1,4,5-triphosphate (IP(3 receptor antagonists, xestospongin C and 2-aminoethoxydiphenyl borate (2-APB treatment. Furthermore, BAPTA-AM, a chelator of intracellular Ca(2+, blocked the effects of ifenprodil on NGF-induced neurite outgrowth, indicating the role of intracellular Ca(2+ in the neurite outgrowth. These findings suggest that activation at sigma-1 receptors and subsequent interaction with IP(3 receptors may mediate the pharmacological effects of ifenprodil on neurite outgrowth.

  15. The Clostridium difficile Dlt Pathway Is Controlled by the Extracytoplasmic Function Sigma Factor σV in Response to Lysozyme.

    Science.gov (United States)

    Woods, Emily C; Nawrocki, Kathryn L; Suárez, Jose M; McBride, Shonna M

    2016-06-01

    Clostridium difficile (also known as Peptoclostridium difficile) is a major nosocomial pathogen and a leading cause of antibiotic-associated diarrhea throughout the world. Colonization of the intestinal tract is necessary for C. difficile to cause disease. Host-produced antimicrobial proteins (AMPs), such as lysozyme, are present in the intestinal tract and can deter colonization by many bacterial pathogens, and yet C. difficile is able to survive in the colon in the presence of these AMPs. Our prior studies established that the Dlt pathway, which increases the surface charge of the bacterium by addition of d-alanine to teichoic acids, is important for C. difficile resistance to a variety of AMPs. We sought to determine what genetic mechanisms regulate expression of the Dlt pathway. In this study, we show that a dlt null mutant is severely attenuated for growth in lysozyme and that expression of the dltDABC operon is induced in response to lysozyme. Moreover, we found that a mutant lacking the extracytoplasmic function (ECF) sigma factor σ(V) does not induce dlt expression in response to lysozyme, indicating that σ(V) is required for regulation of lysozyme-dependent d-alanylation of the cell wall. Using reporter gene fusions and 5' RACE (rapid amplification of cDNA ends) analysis, we identified promoter elements necessary for lysozyme-dependent and lysozyme-independent dlt expression. In addition, we observed that both a sigV mutant and a dlt mutant are more virulent in a hamster model of infection. These findings demonstrate that cell wall d-alanylation in C. difficile is induced by lysozyme in a σ(V)-dependent manner and that this pathway impacts virulence in vivo. PMID:27068095

  16. The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence.

    OpenAIRE

    Solnick, J. V.; Hansen, L M; Syvanen, M

    1997-01-01

    Sequence analysis of the Helicobacter pylori major sigma factor (RpoD) shows that it is highly divergent, which may be related to the marked diversity of the H. pylori chromosome. Furthermore, the rate of divergence of RpoD among other gram-negative bacteria is much greater than that among gram-positive bacteria. This suggests that RpoD from gram-negative bacteria is functionally less constrained than that from gram-positive bacteria.

  17. A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct.

    OpenAIRE

    Shadel, G S; Clayton, D A

    1995-01-01

    In Saccharomyces cerevisiae mitochondria, sc-mtTFB is a 341-amino-acid transcription factor required for initiation of transcription from mitochondrial DNA promoters. Specific transcription in vitro requires only sc-mtTFB and the bacteriophage-related core sc-mtRNA polymerase. Mutational analysis of sc-mtTFB has defined two regions of the protein that are important for normal function both in vivo and in vitro. These regions overlap portions of the protein that exhibit similarity to conserved...

  18. Factoring, a Financing Alternative for Romanian Exporters During Crisis

    OpenAIRE

    Dugan Silvia; Pepenel Madelaine-Lorelai

    2011-01-01

    Factoring, a product used in dynamic business environments worldwide, is a quick solution for the issue of working capital locked in the loan provider, ensuring a productive use of financial resources. During the economic crisis and given the very limited access to traditional financing schemes, factoring may be a suitable alternative for some companies in Romania, particularly those operating in the provision of goods or services. Factoring is therefore a solution to short-term finance compa...

  19. The Role of Responsibility Factors of Reducing Inefficiencies in IS Projects on Six Sigma Certification in Service Organizations

    OpenAIRE

    Sara Hejazi; Yair Levy

    2012-01-01

    Service organizations worldwide are turning to Six Sigma Program (SSP) to remove variability in their processes to attain a competitive marketplace advantage. SSP offers methodology, concepts, and statistical tools to understand and standardize processes by reducing sources of variability. An effective “Belt†certification program, considered a major contributor to successful implementation of SSP as it provides the SSP professionals a clear understanding of what their responsibilities sho...

  20. Induction of Fibronectin Adhesins in Quinolone-Resistant Staphylococcus aureus by Subinhibitory Levels of Ciprofloxacin or by Sigma B Transcription Factor Activity Is Mediated by Two Separate Pathways

    OpenAIRE

    Li, Dongmei; Renzoni, Adriana; Estoppey, Tristan; Bisognano, Carmelo; Francois, Patrice; Kelley, William L; Lew, Daniel P.; Schrenzel, Jacques; Vaudaux, Pierre

    2005-01-01

    We recently reported on the involvement of a RecA-LexA-dependent pathway in the ciprofloxacin-triggered upregulation of fibronectin-binding proteins (FnBPs) by fluoroquinolone-resistant Staphylococcus aureus. The potential additional contribution of the transcription factor sigma B (SigB) to the ciprofloxacin-triggered upregulation of FnBPs was studied in isogenic mutants of fluoroquinolone-resistant strain RA1 (a topoisomerase IV gyrase double mutant of S. aureus NCTC strain 8325), which exh...

  1. RpoH2 sigma factor controls the photooxidative stress response in a non-photosynthetic rhizobacterium, Azospirillum brasilense Sp7.

    Science.gov (United States)

    Kumar, Santosh; Rai, Ashutosh Kumar; Mishra, Mukti Nath; Shukla, Mansi; Singh, Pradhyumna Kumar; Tripathi, Anil Kumar

    2012-12-01

    Bacteria belonging to the Alphaproteobacteria normally harbour multiple copies of the heat shock sigma factor (known as σ(32), σ(H) or RpoH). Azospirillum brasilense, a non-photosynthetic rhizobacterium, harbours five copies of rpoH genes, one of which is an rpoH2 homologue. The genes around the rpoH2 locus in A. brasilense show synteny with that found in rhizobia. The rpoH2 of A. brasilense was able to complement the temperature-sensitive phenotype of the Escherichia coli rpoH mutant. Inactivation of rpoH2 in A. brasilense results in increased sensitivity to methylene blue and to triphenyl tetrazolium chloride (TTC). Exposure of A. brasilense to TTC and the singlet oxygen-generating agent methylene blue induced several-fold higher expression of rpoH2. Comparison of the proteome of A. brasilense with its rpoH2 deletion mutant and with an A. brasilense strain overexpressing rpoH2 revealed chaperone GroEL, elongation factors (Ef-Tu and EF-G), peptidyl prolyl isomerase, and peptide methionine sulfoxide reductase as the major proteins whose expression was controlled by RpoH2. Here, we show that the RpoH2 sigma factor-controlled photooxidative stress response in A. brasilense is similar to that in the photosynthetic bacterium Rhodobacter sphaeroides, but that RpoH2 is not involved in the detoxification of methylglyoxal in A. brasilense.

  2. Alternating proximal gradient method for nonnegative matrix factorization

    CERN Document Server

    Xu, Yangyang

    2011-01-01

    Nonnegative matrix factorization has been widely applied in face recognition, text mining, as well as spectral analysis. This paper proposes an alternating proximal gradient method for solving this problem. With a uniformly positive lower bound assumption on the iterates, any limit point can be proved to satisfy the first-order optimality conditions. A Nesterov-type extrapolation technique is then applied to accelerate the algorithm. Though this technique is at first used for convex program, it turns out to work very well for the non-convex nonnegative matrix factorization problem. Extensive numerical experiments illustrate the efficiency of the alternating proximal gradient method and the accleration technique. Especially for real data tests, the accelerated method reveals high superiority to state-of-the-art algorithms in speed with comparable solution qualities.

  3. What is Six Sigma ?

    OpenAIRE

    Prof. Ph.D. Sorin-George Toma

    2008-01-01

    Over the past decades, several business improvement methods were launched, including the one known as Six Sigma. The Six Sigma implies the application of scientific principles to business processes and allows companies to obtain better, faster and cheaper products and services. Motorola was the first company that introduced and implemented Six Sigma in its business processes in the 1980s.

  4. What is Six Sigma ?

    Directory of Open Access Journals (Sweden)

    Prof. Ph.D. Sorin-George Toma

    2008-12-01

    Full Text Available Over the past decades, several business improvement methods were launched, includingthe one known as Six Sigma. The Six Sigma implies the application of scientific principles to business processesand allows companies to obtain better, faster and cheaper products and services. Motorola was thefirst company that introduced and implemented Six Sigma in its business processes in the 1980s.

  5. Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies.

    Science.gov (United States)

    Sharma, Amit; Leach, Robert N; Gell, Christopher; Zhang, Nan; Burrows, Patricia C; Shepherd, Dale A; Wigneshweraraj, Sivaramesh; Smith, David Alastair; Zhang, Xiaodong; Buck, Martin; Stockley, Peter G; Tuma, Roman

    2014-04-01

    Recognition of bacterial promoters is regulated by two distinct classes of sequence-specific sigma factors, σ(70) or σ(54), that differ both in their primary sequence and in the requirement of the latter for activation via enhancer-bound upstream activators. The σ(54) version controls gene expression in response to stress, often mediating pathogenicity. Its activator proteins are members of the AAA+ superfamily and use adenosine triphosphate (ATP) hydrolysis to remodel initially auto-inhibited holoenzyme promoter complexes. We have mapped this remodeling using single-molecule fluorescence spectroscopy. Initial remodeling is nucleotide-independent and driven by binding both ssDNA during promoter melting and activator. However, DNA loading into the RNA polymerase active site depends on co-operative ATP hydrolysis by the activator. Although the coupled promoter recognition and melting steps may be conserved between σ(70) and σ(54), the domain movements of the latter have evolved to require an activator ATPase.

  6. Expression of the translocator protein (TSPO from Pseudomonas fluorescens Pfo-1 requires the stress regulatory sigma factors AlgU and RpoH

    Directory of Open Access Journals (Sweden)

    Charlène eLeneveu-Jenvrin

    2015-09-01

    Full Text Available The translocator protein (TSPO, previously designated as peripheral-type benzodiazepine receptor, is an evolutionary conserved protein that is found in many Eukarya, Archae and Bacteria, in which it plays several important functions including for example membrane biogenesis, signaling and stress response. A tspo homologue gene has been identified in several members of the Pseudomonas genus, among which the soil bacterium P. fluorescens Pf0-1. In this bacterium, the tspo gene is located in the vicinity of a putative hybrid histidine kinase-encoding gene. Since tspo has been involved in water stress related response in plants, we explored the effects of hyperosmolarity and temperature on P. fluorescens Pf0-1 tspo expression using a strategy based on lux-reporter fusions. We show that the two genes Pfl01_2810 and tspo are co-transcribed forming a transcription unit. The expression of this operon is growth phase-dependent and is increased in response to high concentrations of NaCl, sucrose and to a D-cycloserine treatment, which are conditions leading to activity of the major cell wall stress responsive extracytoplasmic sigma factor AlgU. Interestingly, the promoter region activity is strongly lowered in a P. aeruginosa algU mutant, suggesting that AlgU may be involved at least partly in the molecular mechanism leading to Pfl01_2810-tspo expression. In silico analysis of this promoter region failed to detect an AlgU consensus binding site; however, we detect a putative binding site for the heat shock response RpoH sigma factor. Accordingly, the promoter activity of the region containing this sequence is increased in response to high growth temperature and slightly lowered in a P. aeruginosa rpoH mutant strain. Taken together, our data suggest that P. fluorescens tspo gene may belong at least partly to the cell wall stress response.

  7. Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment.

    Science.gov (United States)

    Martins, Natália; Ferreira, Isabel C F R; Barros, Lillian; Silva, Sónia; Henriques, Mariana

    2014-06-01

    Candidiasis is the most common opportunistic yeast infection. Candida species and other microorganisms are involved in this complicated fungal infection, but Candida albicans continues to be the most prevalent. In the past two decades, it has been observed an abnormal overgrowth in the gastrointestinal, urinary and respiratory tracts, not only in immunocompromised patients, but also related to nosocomial infections and even in healthy individuals. There is a widely variety of causal factors that contribute to yeast infection which means that candidiasis is a good example of a multifactorial syndrome. Due to rapid increase in the incidence in these infections, this is the subject of numerous studies. Recently, the focus of attention is the treatment and, above all, the prevention of those complications. The diagnosis of candidiasis could become quite complicated. Prevention is the most effective "treatment," much more than eradication of the yeast with antifungal agents. There are several aspects to consider in the daily routine that can provide a strength protection. However, a therapeutic approach is necessary when the infection is established, and therefore, other alternatives should be explored. This review provides an overview on predisposition factors, prevention and diagnosis of candidiasis, highlighting alternative approaches for candidiasis treatment.

  8. Identification of the Gene Encoding the Alternative Sigma Factor ςB from Listeria monocytogenes and Its Role in Osmotolerance†

    OpenAIRE

    Becker, Lynne A.; Çetin, Mehmet Sevket; Hutkins, Robert W.; Benson, Andrew K.

    1998-01-01

    Listeria monocytogenes is well known for its robust physiology, which permits growth at low temperatures under conditions of high osmolarity and low pH. Although studies have provided insight into the mechanisms used by L. monocytogenes to allay the physiological consequences of these adverse environments, little is known about how these responses are coordinated. In the studies presented here, we have cloned the sigB gene and several rsb genes from L. monocytogenes, encoding homologs of the ...

  9. Six Sigma software development

    CERN Document Server

    Tayntor, Christine B

    2002-01-01

    Since Six Sigma has had marked success in improving quality in other settings, and since the quality of software remains poor, it seems a natural evolution to apply the concepts and tools of Six Sigma to system development and the IT department. Until now however, there were no books available that applied these concepts to the system development process. Six Sigma Software Development fills this void and illustrates how Six Sigma concepts can be applied to all aspects of the evolving system development process. It includes the traditional waterfall model and in the support of legacy systems,

  10. What is Six Sigma?

    Directory of Open Access Journals (Sweden)

    Gulcin Daglioglu

    2009-04-01

    Full Text Available Sigma (σ refers to Standard Deviation which is a measure of variation in statistics. Methodology of Six Sigma is a management philosophy that is based on the theory that parameters can be cotrolled. Six Sigma applications follow the process of identifying and defining defects, analyzing the defects using various measures, suggesting improvements and having metrics or controls in place to achieve the goals of the business. The error rate is defined as the number of error in a million. An increase in Sigma means decrease in the number of error, and lower values of Sigma correspond to higher number of error. The Six Sigma philosophy aims to bring about improvements in processes that have zero error. The Six Sigma approach is to implement methodologies that aim at reaching world standard quality which is 6 Sigma or more. The Six Sigma methodology used in clinical laboratories appears to be a quality management tool involving statistical calculations, process parameter based, and reports about the process performance. [Archives Medical Review Journal 2009; 18(2.000: 132-139

  11. Quantum Group $\\sigma$ Models

    CERN Document Server

    Frishman, Yitzhak; Zakrzewski, W J

    1993-01-01

    Field-theoretic models for fields taking values in quantum groups are investigated. First we consider $SU_q(2)$ $\\sigma$ model ($q$ real) expressed in terms of basic notions of noncommutative differential geometry. We discuss the case in which the $\\sigma$ models fields are represented as products of conventional $\\sigma$ fields and of the coordinate-independent algebra. An explicit example is provided by the $U_q(2)$ $\\sigma$ model with $q\\sp{N}=1$, in which case quantum matrices $U_q(2)$ are realised as $2N\\times 2N$ unitary matrices. Open problems are pointed out.

  12. Quantum Group $\\sigma$ Models

    OpenAIRE

    Frishman, Y.; Lukierski, J.; Zakrzewski, W. J.

    1992-01-01

    Field-theoretic models for fields taking values in quantum groups are investigated. First we consider $SU_q(2)$ $\\sigma$ model ($q$ real) expressed in terms of basic notions of noncommutative differential geometry. We discuss the case in which the $\\sigma$ models fields are represented as products of conventional $\\sigma$ fields and of the coordinate-independent algebra. An explicit example is provided by the $U_q(2)$ $\\sigma$ model with $q\\sp{N}=1$, in which case quantum matrices $U_q(2)$ ar...

  13. Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation.

    Science.gov (United States)

    Hardy, Jessica G; Norbury, Chris J

    2016-08-15

    Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion causes transcriptome-wide changes in cleavage site use makes it a key candidate regulator of APA. This review aims to summarize current knowledge of the CFIm complex, and explores the evidence surrounding its potential contribution to regulation of APA. PMID:27528751

  14. Multi-Agent Modeling in Managing Six Sigma Projects

    Directory of Open Access Journals (Sweden)

    K. Y. Chau

    2009-10-01

    Full Text Available In this paper, a multi-agent model is proposed for considering the human resources factor in decision making in relation to the six sigma project. The proposed multi-agent system is expected to increase the acccuracy of project prioritization and to stabilize the human resources service level. A simulation of the proposed multiagent model is conducted. The results show that a multi-agent model which takes into consideration human resources when making decisions about project selection and project team formation is important in enabling efficient and effective project management. The multi-agent modeling approach provides an alternative approach for improving communication and the autonomy of six sigma projects in business organizations.

  15. YALIN ALTI SİGMA PROJELERİ İÇİN KRİTİK BAŞARI FAKTÖRLERİ (SUCCESS FACTORS FOR LEAN SIX SIGMA PROJECTS

    Directory of Open Access Journals (Sweden)

    Ali Rıza FİRUZAN

    2012-10-01

    Full Text Available Nowadays many companies focus on various kinds of quality improvement techniques to carry the service quality beyond costumer expectations. The selected quality technique should be appropriate to the company's culture and should be sufficient for carry out targeted improvement; this will enhance the company’s superiority in market place.For this purpose, Lean Six Sigma methods are one of the important methods being used today as an intensive use of statistical tools and techniques. Lean Six Sigma methods can be implemented in almost all sectors and successful gains can be obtained. Lean Six Sigma has wide range application in the world. Most applications are successful, while some of them are failed. In this study, reasons for unsuccessful Lean Six Sigma projects are examined. The way to convert unsuccessful project into successful project are suggested. Some solutions are carried out for this purpose.

  16. A proposal for a novel impact factor as an alternative to the JCR impact factor.

    Science.gov (United States)

    Yang, Zu-Guo; Zhang, Chun-Ting

    2013-12-03

    One disadvantage of the JCR impact factor, the most commonly used assessment tool for ranking and evaluating scientific journals, is its inability in distinguishing among different shapes of citation distribution curves, leading to unfair evaluation of journals in some cases. This paper aims to put forward an alternative impact factor (IF') that can properly reflect citation distributions. The two impact factors are linearly and positively correlated, and have roughly the same order of magnitude. Because of the ability of IF' in distinguishing among different shapes of citation distribution curves, IF' may properly reflect the academic performance of a scientific journal in a way that is different from the JCR impact factor with some unique features that reward journals with highly cited papers. Therefore, it is suggested that IF' could be used to complement the JCR impact factor.

  17. The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile.

    Directory of Open Access Journals (Sweden)

    Glen P Carter

    2011-10-01

    Full Text Available Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment and associated health care practices have provided a niche for the rapid evolution of microbial pathogens that are well adapted to surviving and proliferating in this setting, after which they can infect susceptible patients. This is clearly the case for bacterial pathogens such as Methicillin Resistant Staphylococcus aureus (MRSA and Vancomycin Resistant Enterococcus (VRE species, both of which have acquired resistance to antimicrobial agents as well as enhanced survival and virulence properties that present serious therapeutic dilemmas for treating physicians. It has recently become apparent that the spore-forming bacterium Clostridium difficile also falls within this category. Since 2000, there has been a striking increase in C. difficile nosocomial infections worldwide, predominantly due to the emergence of epidemic or hypervirulent isolates that appear to possess extended antibiotic resistance and virulence properties. Various hypotheses have been proposed for the emergence of these strains, and for their persistence and increased virulence, but supportive experimental data are lacking. Here we describe a genetic approach using isogenic strains to identify a factor linked to the development of hypervirulence in C. difficile. This study provides evidence that a naturally occurring mutation in a negative regulator of toxin production, the anti-sigma factor TcdC, is an important factor in the development of hypervirulence in epidemic C. difficile isolates, presumably because the mutation leads to significantly increased toxin production, a contentious hypothesis until now. These results have important implications for C. difficile pathogenesis and virulence since they suggest that strains carrying a similar mutation have the inherent potential to develop a hypervirulent phenotype.

  18. Supersymmetric sigma models

    International Nuclear Information System (INIS)

    We begin to construct the most general supersymmetric Lagrangians in one, two and four dimensions. We find that the matter couplings have a natural interpretation in the language of the nonlinear sigma model

  19. Supersymmetric sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Bagger, J.A.

    1984-09-01

    We begin to construct the most general supersymmetric Lagrangians in one, two and four dimensions. We find that the matter couplings have a natural interpretation in the language of the nonlinear sigma model.

  20. Using Six Sigma to improve complaints handling

    OpenAIRE

    Patricia Abreu; Sergio Sousa; Isabel Lopes

    2012-01-01

    Currently, companies are in increasingly competitive environment in which customers’ satisfaction and loyalty are vital factors in the success of any organisation. This requires the use of continuous improvement methodologies, such as Six Sigma, which enable companies to improve customer satisfaction and meet their expectations. This paper describes a case study carried out in a company from the automotive industry that has selected a Six Sigma project to respond to a decrease in customer ...

  1. 6 Sigma project advance

    International Nuclear Information System (INIS)

    This book deals with 6 sigma project advance which introduces 6 sigma project in Changwon special steel, how is failure accepted? CTQ selection which is starting line, definition of performance standard, measurement system check on reliability of measurement data, check of process capacity for current level, establishment of target, optimal design and performance of application, practice of management system for maintain of improved result, CTQ selection, check of measurement system and practice of management system.

  2. Sigma models on supercosets

    Energy Technology Data Exchange (ETDEWEB)

    Mitev, Vladimir

    2010-08-15

    The purpose of this thesis is to deepen our understanding of the fundamental properties and defining features of non-linear sigma models on superspaces. We begin by presenting the major concepts that we have used in our investigation, namely Lie superalgebras and supergroups, non-linear sigma models and two dimensional conformal field theory. We then exhibit a method, called cohomological reduction, that makes use of the target space supersymmetry of non-linear sigma models to compute certain correlation functions. We then show how the target space supersymmetry of Ricci flat Lie supergroups simplifies the perturbation theory of suitable deformed Wess-Zumino-Witten models, making it possible to compute boundary conformal weights to all orders. This is then applied to the OSP (2S+2 vertical stroke 2S) Gross-Neveu Model, leading to a dual description in terms of the sigma model on the supersphere S{sup 2S+1} {sup vertical} {sup stroke} {sup 2S}. With this results in mind, we then turn to the similar, yet more intricate, theory of the non-linear sigma model on the complex projective superspaces CP{sup N-1} {sup vertical} {sup stroke} {sup N}. The cohomological reduction allows us to compute several important quantities non-perturbatively with the help of the system of symplectic fermions. Combining this with partial perturbative results for the whole theory, together with numerical computations, we propose a conjecture for the exact evolution of boundary conformal weights for symmetry preserving boundary conditions. (orig.)

  3. The extracytoplasmic function sigma factor SigV plays a key role in the original model of lysozyme resistance and virulence of Enterococcus faecalis.

    Directory of Open Access Journals (Sweden)

    André Le Jeune

    Full Text Available BACKGROUND: Enterococcus faecalis is one of the leading agents of nosocomial infections. To cause diseases, pathogens or opportunistic bacteria have to adapt and survive to the defense systems encountered in the host. One of the most important compounds of the host innate defense response against invading microorganisms is lysozyme. It is found in a wide variety of body fluids, as well as in cells of the innate immune system. Lysozyme could act either as a muramidase and/or as a cationic antimicrobial peptide. Like Staphylococcus aureus, E. faecalis is one of the few bacteria that are completely lysozyme resistant. RESULTS: This study revealed that oatA (O-acetyl transferase and dlt (D-Alanylation of lipoteicoic acids genes contribute only partly to the lysozyme resistance of E. faecalis and that a specific transcriptional regulator, the extracytoplasmic function SigV sigma factor plays a key role in this event. Indeed, the sigV single mutant is as sensitive as the oatA/dltA double mutant, and the sigV/oatA/dltA triple mutant displays the highest level of lysozyme sensitivity suggesting synergistic effects of these genes. In S. aureus, mutation of both oatA and dlt genes abolishes completely the lysozyme resistance, whereas this is not the case in E. faecalis. Interestingly SigV does not control neither oatA nor dlt genes. Moreover, the sigV mutants clearly showed a reduced capacity to colonize host tissues, as they are significantly less recovered than the parental JH2-2 strain from organs of mice subjected to intravenous or urinary tract infections. CONCLUSIONS: This work led to the discovery of an original model of lysozyme resistance mechanism which is obviously more complex than those described for other Gram positive pathogens. Moreover, our data provide evidences for a direct link between lysozyme resistance and virulence of E. faecalis.

  4. Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.

    NARCIS (Netherlands)

    Heyd, F.; Dam, G.B. ten; Moroy, T.

    2006-01-01

    By alternative splicing, different isoforms of the transmembrane tyrosine phosphatase CD45 are generated that either enhance or limit T cell receptor signaling. We report here that CD45 alternative splicing is regulated by cooperative action of the splice factor U2AF26 and the transcription factor G

  5. Delta-Sigma Beamforming

    OpenAIRE

    2005-01-01

    Systems where data is collected using arrays of sensors will usually contain a beamformer. When the number of active channels in the sensor array is large, as it often is in imaging systems like sonar and medical ultrasound, the beamformer can be both physically large and expensive. To counteract one or both of these unwanted effects, several compact beamforming solutions have been suggested. Delta-sigma based beamforming is one such technique, where 1-bit delta-sigma A/D converters are used ...

  6. The human resource management contribute six sigma program: multiple-case study in companies situated in Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Jaqueline T. M. Corrêa Rodrigues

    2011-09-01

    Full Text Available The world is going through rapid changes and the companies seek alternatives to improve its products and processes and maintain their competitiveness. One alternative is the implementation of programs of quality management that combine human’s and technical’s factors. Six Sigma has gained evidence on the last years because aggregate tools and methodology. However, all quality program factors need management. The main goal of this paper is classify what assignments of Human Resource Management can contribute to reduction of the difficulties that can be encountered on implementation and maintenance of Six Sigma program in companies that was situated in the Rio Grande do Sul. For carry this work was necessary contact companies of the Rio Grande do Sul that use this program and was applied one questionnaire to classify the contribution of the Human Resource Management for the success of Six Sigma. The statistical tools, contents analyze, tables of relationship and qualitative analysis were applied for analysis. It’s evidence in this research the existence of potentials difficulties of Six Sigma listed in the literature and the influence that some assignments of Human Resource Management can be for solve this difficulties. The result of the research indicate that the participative and compromised leadership and the clear and objective communication of program are the assignments of Human Resource Management among the studied that more contribute for reduction of the difficulties of Six Sigma in the companies of this research.

  7. A Review: Six Sigma Implementation Practice in Manufacturing Industries

    Directory of Open Access Journals (Sweden)

    Riddhish Thakore

    2014-11-01

    Full Text Available Higher Productivity achievement is very crucial factor for the field of production. With the High productivity various other factors must be taken in to consideration in manufacturing industries such as global competitors, diversity in product range, lead time and customer demand in terms of quality and quantity. A new benchmark called Six Sigma has been invented for dealing with all these needs. Six sigma is a quality initiative which reduces variations in a process and helps to lower the cost of product as well as process. The objective of this paper is to review and examine the advancement and encounters of six sigma practices in Global manufacturing Industries and identify the key tools for each step in successful Six Sigma project execution. The paper also integrates the lessons learned from successful six sigma projects and their prospective applications in various manufacturing Industries. In today scenario, many global manufacturing industries operate their processes at the two to four sigma quality levels.

  8. Inclusive $\\Sigma^{+}$ and $\\Sigma^{0}$ Production in Hadronic Z Decays

    CERN Document Server

    Acciarri, M; Adriani, O; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, L; Balandras, A; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Barone, L; Bartalini, P; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Bhattacharya, S; Biasini, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böhm, A; Boldizsar, L; Borgia, B; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brigljevic, V; Brochu, F; Buffini, A; Buijs, A; Burger, J D; Burger, W J; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Coignet, G; Colijn, A P; Colino, N; Costantini, S; Cotorobai, F; Cozzoni, B; de la Cruz, B; Csilling, Akos; Cucciarelli, S; Dai, T S; van Dalen, J A; D'Alessandro, R; De Asmundis, R; Déglon, P L; Degré, A; Deiters, K; Della Volpe, D; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dova, M T; Duchesneau, D; Dufournaud, D; Duinker, P; Durán, I; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Extermann, Pierre; Fabre, M; Faccini, R; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Ferguson, T; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisk, I; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gau, S S; Gentile, S; Gheordanescu, N; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hasan, A; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hidas, P; Hirschfelder, J; Hofer, H; Holzner, G; Hoorani, H; Hou, S R; Hu, Y; Iashvili, I; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Khan, R A; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Kopp, A; Koutsenko, V F; Kräber, M H; Krämer, R W; Krenz, W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lassila-Perini, K M; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee, H J; Le Goff, J M; Leiste, R; Leonardi, E; Levchenko, P M; Li Chuan; Likhoded, S A; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Lugnier, L; Luminari, L; Lustermann, W; Ma Wen Gan; Maity, M; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mans, J; Marchesini, P A; Marian, G; Martin, J P; Marzano, F; Massaro, G G G; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Molnár, P; Monteleoni, B; Moulik, T; Muanza, G S; Muheim, F; Muijs, A J M; Musy, M; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nisati, A; Nowak, H; Organtini, G; Oulianov, A; Palomares, C; Pandoulas, D; Paoletti, S; Paolucci, P; Paramatti, R; Park, H K; Park, I H; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pieri, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Pothier, J; Produit, N; Prokofev, D; Prokofiev, D O; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Raspereza, A V; Raven, G; Razis, P A; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riles, K; Robohm, A; Rodin, J; Roe, B P; Romero, L; Rosca, A; Rosier-Lees, S; Rubio, Juan Antonio; Ruschmeier, D; Rykaczewski, H; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Sanders, M P; Sarakinos, M E; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schopper, Herwig Franz; Schotanus, D J; Schwering, G; Sciacca, C; Sciarrino, D; Seganti, A; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Stone, A; Stone, H; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Suter, H; Swain, J D; Szillási, Z; Sztaricskai, T; Tang, X W; Tauscher, Ludwig; Taylor, L; Tellili, B; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Uchida, Y; Ulbricht, J; Valente, E; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, M; Wang, X L; Wang, Z M; Weber, A; Weber, M; Wienemann, P; Wilkens, H; Wu, S X; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Ye, J B; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhu, G Y; Zhu, R Y; Zichichi, A; Zilizi, G; Zöller, M

    2000-01-01

    We report on measurements of the inclusive production rate of $\\Sigma^+$ and $\\Sigma^0$ baryons in hadronic Z decays collected with the L3 detector at LEP. The $\\Sigma^+$ baryons are detected through the decay $\\Sigma^+ \\rightarrow {\\rm p} \\pi^0$, while the $\\Sigma^0$ baryons are detected via the decay mode $\\Sigma^0 \\rightarrow \\Lambda \\gamma$. The average numbers of $\\Sigma^+$ and $\\Sigma^0$ per hadronic Z decay are measured to be: \\begin{eqnarray*} \\left + \\left & = & 0.114 \\pm 0.011_{\\mbox{\\it \\small stat}} \\pm 0.009_{\\mbox{\\it \\small syst}} \\\\ \\left + \\left & = & 0.095 \\pm 0.015_{\\mbox{\\it \\small stat}} \\pm 0.013_{\\mbox{\\it \\small syst}} \\ \\mbox{.} \\end{eqnarray*} These rates are found to be higher than the predictions from Monte Carlo hadronization models and analytical parameterizations of strange baryon production.

  9. Definition of the sigma(W) Regulon of Bacillus subtilis in the Absence of Stress

    NARCIS (Netherlands)

    Zweers, Jessica C.; Nicolas, Pierre; Wiegert, Thomas; van Dijl, Jan Maarten; Denham, Emma L.

    2012-01-01

    Bacteria employ extracytoplasmic function (ECF) sigma factors for their responses to environmental stresses. Despite intensive research, the molecular dissection of ECF sigma factor regulons has remained a major challenge due to overlaps in the ECF sigma factor-regulated genes and the stimuli that a

  10. Induction of Fibronectin Adhesins in Quinolone-Resistant Staphylococcus aureus by Subinhibitory Levels of Ciprofloxacin or by Sigma B Transcription Factor Activity Is Mediated by Two Separate Pathways

    Science.gov (United States)

    Li, Dongmei; Renzoni, Adriana; Estoppey, Tristan; Bisognano, Carmelo; Francois, Patrice; Kelley, William L.; Lew, Daniel P.; Schrenzel, Jacques; Vaudaux, Pierre

    2005-01-01

    We recently reported on the involvement of a RecA-LexA-dependent pathway in the ciprofloxacin-triggered upregulation of fibronectin-binding proteins (FnBPs) by fluoroquinolone-resistant Staphylococcus aureus. The potential additional contribution of the transcription factor sigma B (SigB) to the ciprofloxacin-triggered upregulation of FnBPs was studied in isogenic mutants of fluoroquinolone-resistant strain RA1 (a topoisomerase IV gyrase double mutant of S. aureus NCTC strain 8325), which exhibited widely different levels of SigB activity, as assessed by quantitative reverse transcription-PCR of their respective sigB and SigB-dependent asp23 transcript levels. These mutants were Tn551 insertion sigB strain TE1 and rsbU+ complemented strain TE2, which exhibited a wild-type SigB operon. Levels of FnBP surface display and fibronectin-mediated adhesion were lower in sigB mutant TE1 or higher in the rsbU+-restored strain TE2 compared to their sigB+ but rsbU parent, strain RA1, exhibiting low levels of SigB activity. Steady-state fnbA and fnbB transcripts levels were similar in strains TE1 and RA1 but increased by 4- and 12-fold, respectively, in strain TE2 compared to those in strain RA1. In contrast, fibronectin-mediated adhesion of strains TE1, RA1, and TE2 was similarly enhanced by growth in the presence of one-eighth the MIC of ciprofloxacin, which led to a significantly higher increase in their fnbB transcript levels compared to the increase in their fnbA transcript levels. Increased SigB levels led to a significant reduction in agr RNAIII; in contrast, it led to a slight increase in sarA transcript levels. In conclusion, upregulation of FnBPs by increased SigB levels and ciprofloxacin exposure in fluoroquinolone-resistant S. aureus occurs via independent pathways whose concerted actions may significantly promote bacterial adhesion and colonization. PMID:15728884

  11. A novel hybrid kinase is essential for regulating the sigma(B)-mediated stress response of Bacillus cereus.

    Science.gov (United States)

    de Been, Mark; Tempelaars, Marcel H; van Schaik, Willem; Moezelaar, Roy; Siezen, Roland J; Abee, Tjakko

    2010-03-01

    A common bacterial strategy for monitoring environmental challenges is to use two-component systems, which consist of a sensor histidine kinase (HK) and a response regulator (RR). In the food-borne pathogen Bacillus cereus, the alternative sigma factor sigma(B) is activated by the RR RsbY. Here we present strong indications that the PP2C-type phosphatase RsbY receives its input from the multi-sensor hybrid kinase BC1008 (renamed RsbK). Genome analyses revealed that, across bacilli, rsbY and rsbK are located in a conserved gene cluster. A B. cereus rsbK deletion strain was shown to be incapable of inducing sigma(B) upon stress conditions and was impaired in its heat adaptive response. Comparison of the wild-type and rsbK mutant transcriptomes upon heat shock revealed that RsbK was primarily involved in the activation of the sigma(B)-mediated stress response. Truncation of the RsbK RR receiver domain demonstrated the importance of this domain for sigma(B) induction upon stress. The domain architecture of RsbK suggests that in the B. cereus group and in other bacilli, environmental and intracellular stress signalling routes are combined into one single protein. This strategy is markedly different from the sigma(B) activation pathway in other low-GC Gram-positives.

  12. Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome.

    Science.gov (United States)

    Shi, Jianhua; Zhang, Tianyi; Zhou, Chunlei; Chohan, Muhammad Omar; Gu, Xiaosong; Wegiel, Jerzy; Zhou, Jianhua; Hwang, Yu-Wen; Iqbal, Khalid; Grundke-Iqbal, Inge; Gong, Cheng-Xin; Liu, Fei

    2008-10-17

    Two groups of tau, 3R- and 4R-tau, are generated by alternative splicing of tau exon 10. Normal adult human brain expresses equal levels of them. Disruption of the physiological balance is a common feature of several tauopathies. Very early in their life, individuals with Down syndrome (DS) develop Alzheimer-type tau pathology, the molecular basis for which is not fully understood. Here, we demonstrate that Dyrk1A, a kinase encoded by a gene in the DS critical region, phosphorylates alternative splicing factor (ASF) at Ser-227, Ser-234, and Ser-238, driving it into nuclear speckles and preventing it from facilitating tau exon 10 inclusion. The increased dosage of Dyrk1A in DS brain due to trisomy of chromosome 21 correlates to an increase in 3R-tau level, which on abnormal hyperphosphorylation and aggregation of tau results in neurofibrillary degeneration. Imbalance of 3R- and 4R-tau in DS brain by Dyrk1A-induced dysregulation of alternative splicing factor-mediated alternative splicing of tau exon 10 represents a novel mechanism of neurofibrillary degeneration and may help explain early onset tauopathy in individuals with DS.

  13. Male infertility: lifestyle factors and holistic, complementary, and alternative therapies

    Science.gov (United States)

    Yao, David F; Mills, Jesse N

    2016-01-01

    While we may be comfortable with an allopathic approach to male infertility, we are also responsible for knowledge about lifestyle modifications and holistic, complementary, and alternative therapies that are used by many of our patients. This paper provides an evidence-based review separating fact from fiction for several of these therapies. There is sufficient literature to support weight reduction by diet and exercise, smoking cessation, and alcohol moderation. Supplements that have demonstrated positive effects on male fertility on small randomized controlled trial (RCT) include aescin, coenzyme Q10, glutathione, Korean red ginseng, L-carnitine, nigella sativa, omega-3, selenium, a combination of zinc and folate, and the Menevit antioxidant. There is no support for the use of Vitamin C, Vitamin E, or saffron. The data for Chinese herbal medications, acupuncture, mind-body practice, scrotal cooling, and faith-based healing are sparse or inconclusive. PMID:26952957

  14. Male infertility: lifestyle factors and holistic, complementary, and alternative therapies

    Directory of Open Access Journals (Sweden)

    David F Yao

    2016-01-01

    Full Text Available While we may be comfortable with an allopathic approach to male infertility, we are also responsible for knowledge about lifestyle modifications and holistic, complementary, and alternative therapies that are used by many of our patients. This paper provides an evidence-based review separating fact from fiction for several of these therapies. There is sufficient literature to support weight reduction by diet and exercise, smoking cessation, and alcohol moderation. Supplements that have demonstrated positive effects on male fertility on small randomized controlled trial (RCT include aescin, coenzyme Q 10 , glutathione, Korean red ginseng, L-carnitine, nigella sativa, omega-3, selenium, a combination of zinc and folate, and the Menevit antioxidant. There is no support for the use of Vitamin C, Vitamin E, or saffron. The data for Chinese herbal medications, acupuncture, mind-body practice, scrotal cooling, and faith-based healing are sparse or inconclusive.

  15. Male infertility: lifestyle factors and holistic, complementary, and alternative therapies.

    Science.gov (United States)

    Yao, David F; Mills, Jesse N

    2016-01-01

    While we may be comfortable with an allopathic approach to male infertility, we are also responsible for knowledge about lifestyle modifications and holistic, complementary, and alternative therapies that are used by many of our patients. This paper provides an evidence-based review separating fact from fiction for several of these therapies. There is sufficient literature to support weight reduction by diet and exercise, smoking cessation, and alcohol moderation. Supplements that have demonstrated positive effects on male fertility on small randomized controlled trial (RCT) include aescin, coenzyme Q 10 , glutathione, Korean red ginseng, L-carnitine, nigella sativa, omega-3, selenium, a combination of zinc and folate, and the Menevit antioxidant. There is no support for the use of Vitamin C, Vitamin E, or saffron. The data for Chinese herbal medications, acupuncture, mind-body practice, scrotal cooling, and faith-based healing are sparse or inconclusive. PMID:26952957

  16. Six Sigma pricing.

    Science.gov (United States)

    Sodhi, ManMohan S; Sodhi, Navdeep S

    2005-05-01

    Many companies are now good at managing costs and wringing out manufacturing efficiencies. The TQM movement and the disciplines of Six Sigma have seen to that. But the discipline so often brought to the cost side of the business equation is found far less commonly on the revenue side. The authors describe how a global manufacturer of industrial equipment, which they call Acme Incorporated, recently applied Six Sigma to one major revenue related activity--the price-setting process. It seemed to Acme's executives that pricing closely resembled many manufacturing processes. So, with the help of a Six Sigma black belt from manufacturing, a manager from Acme's pricing division recruited a team to carry out the five Six Sigma steps: Define what constitutes a defect. At Acme, a defect was an item sold at an unauthorized price. Gather data and prepare it for analysis. That involved mapping out the existing pricing-agreement process. Analyze the data. The team identified the ways in which people failed to carry out or assert effective control at each stage. Recommend modifications to the existing process. The team sought to decrease the number of unapproved prices without creating an onerous approval apparatus. Create controls. This step enabled Acme to sustain and extend the improvements in its pricing procedures. As a result of the changes, Acme earned dollar 6 million in additional revenue on one product line alone in the six months following implementation--money that went straight to the bottom line. At the same time, the company removed much of the organizational friction that had long bedeviled its pricing process. Other companies can benefit from Acme's experience as they look for ways to exercise price control without alienating customers. PMID:15929409

  17. DESIGN FOR SIX SIGMA

    Directory of Open Access Journals (Sweden)

    Liem Ferryanto

    2007-01-01

    Full Text Available This article provides a step by step process of executing analytical or computer based Design for Six Sigma using a Sliding Door project as an example. It comprises of identification of Voice Of the Customer (VOC, transformation of VOC to what it is called Critical To Quality characteristics (CTQs, modeling of system transfers function, optimal and robust solutions, and tolerance design approach

  18. Six Sigma pricing.

    Science.gov (United States)

    Sodhi, ManMohan S; Sodhi, Navdeep S

    2005-05-01

    Many companies are now good at managing costs and wringing out manufacturing efficiencies. The TQM movement and the disciplines of Six Sigma have seen to that. But the discipline so often brought to the cost side of the business equation is found far less commonly on the revenue side. The authors describe how a global manufacturer of industrial equipment, which they call Acme Incorporated, recently applied Six Sigma to one major revenue related activity--the price-setting process. It seemed to Acme's executives that pricing closely resembled many manufacturing processes. So, with the help of a Six Sigma black belt from manufacturing, a manager from Acme's pricing division recruited a team to carry out the five Six Sigma steps: Define what constitutes a defect. At Acme, a defect was an item sold at an unauthorized price. Gather data and prepare it for analysis. That involved mapping out the existing pricing-agreement process. Analyze the data. The team identified the ways in which people failed to carry out or assert effective control at each stage. Recommend modifications to the existing process. The team sought to decrease the number of unapproved prices without creating an onerous approval apparatus. Create controls. This step enabled Acme to sustain and extend the improvements in its pricing procedures. As a result of the changes, Acme earned dollar 6 million in additional revenue on one product line alone in the six months following implementation--money that went straight to the bottom line. At the same time, the company removed much of the organizational friction that had long bedeviled its pricing process. Other companies can benefit from Acme's experience as they look for ways to exercise price control without alienating customers.

  19. Study ofe+e- to Lambda anti-Lambda, Lambda anti-Sigma^0,Sigma^0 anti-Sigma^0 using Initial State Radiation with BaBar

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2007-09-14

    We study the e+e- --> Lambda anti-Lambda gamma, Lambda anti-Sigma0 gamma, Sigma0 anti-Sigma0 gamma processes using 230 fb-1 of integrated luminosity collected by the BaBar detector at e+e- center-of-mass energy of 10.58 GeV. From the analysis of the baryon-antibaryon mass spectra the cross sections for e+e- --> Lambda anti-Lambda, Lambda anti-Sigma0, Sigma0 anti-Sigma0 are measured in the dibaryon mass range from threshold up to 3 GeV/c{sup 2}. The ratio of electric and magnetic form factors, |G{sub E}/G{sub M}|, is measured for e+e- --> Lambda anti-Lambda, and limits on the relative phase between Lambda form factors are obtained. We also measure the J/psi --> Lambda anti-Lambda, Sigma0 anti-Sigma0 and psi(2S) --> Lambda anti-Lambda branching fractions.

  20. The role of sigmaB in the stress response of Gram-positive bacteria - targets for food preservation and safety

    NARCIS (Netherlands)

    Schaik, van W.; Abee, T.

    2005-01-01

    The alternative sigma factor ¿B modulates the stress response of several Gram-positive bacteria, including Bacillus subtilis and the food-borne human pathogens Bacillus cereus, Listeria monocytogenes and Staphylococcus aureus. In all these bacteria, ¿B is responsible for the transcription of genes t

  1. An Alternative to Free Entropy for Free Group Factors

    Institute of Scientific and Technical Information of China (English)

    Michal DOSTAL; Don HADWIN

    2003-01-01

    In this paper we defiue a very simple invariant η(V→) for a k-tuple V→ of unitaries in a finitefactor von Neumann algebra, and we show how this invariant can replace free entropy in many of theimportant applications. We also introduce a notion of metric free entropy and some related concepts.We include proofs, using η, of the theorems of Liming Ge and of D. Voiculescu, respectively, on theprimeness of and on the absence of Cartan subalgebras in the noncommutative free group factors.

  2. 选择性σ因子SigF影响耻垢分枝杆菌的抗氧化能力%Sigma factor F regulates Mycobacterium smegmatis hydrogen peroxide resistance

    Institute of Scientific and Technical Information of China (English)

    吴寒宇; 胡新玲; 肖璟; 张京阳; 陶均; 黄红兰; 米凯霞

    2012-01-01

    [目的]σ因子是细菌RNA聚合酶全酶的重要组分,包括必须σ因子和选择性σ因子.SigF作为重要的选择性σ因子影响结核分枝杆菌(Mycobacterium tuberculosis)的致病性和毒力等重要的功能.与之对应的在非致病性、快速生长的分枝杆菌耻垢分枝杆菌(M.smegmatis)中,sigF的调控可能与其适应一定的生理环境相关.[方法]通过基因敲除、遗传互补和抗药性分析,系统的研究了耻垢分枝杆菌SigF的应答调控.[结果]sigF敲除菌株与野生菌相比,对过氧化氢特别敏感,并且这种敏感性能够通过反式互补野生型的基因得到回复 ;由于细菌体内的抗氧化能力与耐药性有较高的相关性,进一步分析sigF敲除菌株的抗药性和抗氧化相关基因的表达情况,显示SigF影响细菌清除过氧化氢的能力,但是并不影响包括异烟肼等药物的敏感性及与异烟肼敏感性相关基因的表达.[结论]SigF调控的活性氧胁迫应答途径与异烟肼活化的氧化胁迫应答途径不同.另外,实验显示SigF参与了耻垢分枝杆菌的色素的合成,提示SigF参与的是光氧化胁迫应答途径,与药物引起的氧化胁迫应答途径是不同的通路.%A sigma factor is an important component of RNA polymerase complex and is essential for initiation of RNA synthesis. The sigma factors fall into 2 categories; primary sigma factor is essential for bacterial growth and the alterative sigma factor is activated under different environmental conditions. Sigma F ( SigF) is one of the sigma factors of Mycobacterium tuberculosis, affecting its virulence and pathogenesis. In contrast, the ortholog of the non-virulent, fast growing strain Mycobacterium smegmatis has been suggested without similar physiology roles. Here, we studied the functions of M. smegmatis SigF. [Methods] sigF knockout Mycobacterium smegmatis strain was constructed by specialized transduction. The wild type, knockout and complementary stains were

  3. Sigma-model aether

    OpenAIRE

    Carroll, Sean M.; Dulaney, Timothy R.; Gresham, Moira I.; Tam, Heywood

    2009-01-01

    Theories of low-energy Lorentz violation by a fixed-norm "aether" vector field with two-derivative kinetic terms have a globally bounded Hamiltonian and are perturbatively stable only if the vector is timelike and the kinetic term in the action takes the form of a sigma model. Here we investigate the phenomenological properties of this theory. We first consider the propagation of modes in the presence of gravity, and show that there is a unique choice of curvature coupling that leads to a the...

  4. (Sigma-Delta) Codes

    OpenAIRE

    Boulagouaz, M.; Leroy, A

    2013-01-01

    In this paper we introduce the notion of cyclic ($f(t),\\sigma,\\delta$)-codes for $f(t)\\in \\Ore$. These codes generalize the $\\theta$-codes as introduced by D. Boucher, F. Ulmer, W. Geiselmann \\cite{BGU}. We construct generic and control matrices for these codes. As a particular case the ($\\si,\\de$)-$W$-code associated to a Wedderburn polynomial are defined and we show that their control matrices are given by generalized Vandermonde matrices. All the Wedderburn polynomials of $\\mathbb F_q[t;\\t...

  5. Alternative splicing regulation during C. elegans development: splicing factors as regulated targets.

    Directory of Open Access Journals (Sweden)

    Sergio Barberan-Soler

    2008-02-01

    Full Text Available Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect alternative splicing for 352 cassette exons and tested for changes in alternative splicing of these genes during development. We found that the microarray data predicted that 62/352 (approximately 18% of the alternative splicing events studied show a strong change in the relative levels of the spliced isoforms (>4-fold during development. Confirmation of the microarray data by RT-PCR was obtained for 70% of randomly selected genes tested. Among the genes with the most developmentally regulated alternatively splicing was the hnRNP F/H splicing factor homolog, W02D3.11 - now named hrpf-1. For the cassette exon of hrpf-1, the inclusion isoform comprises 65% of hrpf-1 steady state messages in embryos but only 0.1% in the first larval stage. This dramatic change in the alternative splicing of an alternative splicing factor suggests a complex cascade of splicing regulation during development. We analyzed splicing in embryos from a strain with a mutation in the splicing factor sym-2, another hnRNP F/H homolog. We found that approximately half of the genes with large alternative splicing changes between the embryo and L1 stages are regulated by sym-2 in embryos. An analysis of the role of nonsense-mediated decay in regulating steady-state alternative mRNA isoforms was performed. We found that 8% of the 352 events studied have alternative isoforms whose relative steady-state levels in embryos change more than 4-fold in a nonsense-mediated decay mutant, including hrpf-1. Strikingly, 53% of these alternative splicing events that are affected by NMD in our experiment are not obvious substrates for NMD based on the presence of premature termination codons. This suggests that the targeting of splicing factors

  6. Observation of the Heavy Baryons Sigma b and Sigma b*.

    Science.gov (United States)

    Aaltonen, T; Abulencia, A; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P-H; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Cilijak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca Almenar, C; Cuevas, J; Culbertson, R; Cully, J C; DaRonco, S; Datta, M; D'Auria, S; Davies, T; Dagenhart, D; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'Orso, M; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Dörr, C; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernandez, J P; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Grundler, U; Guimaraes da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B-Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Hocker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S-C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraan, A C; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lu, R-S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martínez-Ballarín, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moon, C S; Moore, R; Morello, M; Movilla Fernandez, P; Mülmenstädt, J; Mukherjee, A; Muller, Th; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S

    2007-11-16

    We report an observation of new bottom baryons produced in pp collisions at the Tevatron. Using 1.1 fb(-1) of data collected by the CDF II detector, we observe four Lambda b 0 pi+/- resonances in the fully reconstructed decay mode Lambda b 0-->Lambda c + pi-, where Lambda c+-->pK* pi+. We interpret these states as the Sigma b(*)+/- baryons and measure the following masses: m Sigma b+=5807.8 -2.2 +2.0(stat.)+/-1.7(syst.) MeV/c2, m Sigma b- =5815.2+/-1.0(stat.)+/-1.7(syst.) MeV/c2, and m(Sigma b*)-m(Sigma b)=21.2-1.9 +2.0(stat.)-0.3+0.4(syst.) MeV/c2. PMID:18233134

  7. Design For Six Sigma

    OpenAIRE

    Greplová, Kristýna

    2012-01-01

    Cílem diplomové práce je analýza mezí praktického uplatnění obtokového ventilu TwinScroll turbodmychadla automobilu BMW X6 M užitím nástrojů DFSS (Design For Six Sigma). Cílem je tedy vytvoření speciálního přípravku pro měření těsnosti obtokového ventilu s možností otestování nejrůznějších charakteristik majících vliv na klíčové parametry turbodmychadla.

  8. Improving Quality of Seal Leak Test Product using Six Sigma

    Science.gov (United States)

    Luthfi Malik, Abdullah; Akbar, Muhammad; Irianto, Dradjad

    2016-02-01

    Seal leak test part is a polyurethane material-based product. Based on past data, defect level of this product was 8%, higher than the target of 5%. Quality improvement effort was done using six sigma method that included phases of define, measure, analyse, improve, and control. In the design phase, a Delphi method was used to identify factors that were critical to quality. In the measure phase, stability and process capability was measured. Fault tree analysis (FTA) and failure mode and effect analysis (FMEA) were used in the next phase to analize the root cause and to determine the priority issues. Improve phase was done by compiling, selecting, and designing alternative repair. Some improvement efforts were identified, i.e. (i) making a checklist for maintenance schedules, (ii) making written reminder form, (iii) modifying the SOP more detail, and (iv) performing a major service to the vacuum machine. To ensure the continuity of improvement efforts, some control activities were executed, i.e. (i) controlling, monitoring, documenting, and setting target frequently, (ii) implementing reward and punishment system, (iii) adding cleaning tool, and (iv) building six sigma organizational structure.

  9. Regulation of Splicing Factors by Alternative Splicing and NMD Is Conserved between Kingdoms Yet Evolutionarily Flexible

    OpenAIRE

    Liana F Lareau; Brenner, Steven E.

    2015-01-01

    Ultraconserved elements, unusually long regions of perfect sequence identity, are found in genes encoding numerous RNA-binding proteins including arginine-serine rich (SR) splicing factors. Expression of these genes is regulated via alternative splicing of the ultraconserved regions to yield mRNAs that are degraded by nonsense-mediated mRNA decay (NMD), a process termed unproductive splicing (Lareau et al. 2007; Ni et al. 2007). As all human SR genes are affected by alternative splicing and N...

  10. Method for exploiting bias in factor analysis using constrained alternating least squares algorithms

    Science.gov (United States)

    Keenan, Michael R.

    2008-12-30

    Bias plays an important role in factor analysis and is often implicitly made use of, for example, to constrain solutions to factors that conform to physical reality. However, when components are collinear, a large range of solutions may exist that satisfy the basic constraints and fit the data equally well. In such cases, the introduction of mathematical bias through the application of constraints may select solutions that are less than optimal. The biased alternating least squares algorithm of the present invention can offset mathematical bias introduced by constraints in the standard alternating least squares analysis to achieve factor solutions that are most consistent with physical reality. In addition, these methods can be used to explicitly exploit bias to provide alternative views and provide additional insights into spectral data sets.

  11. Lean Six Sigma For Dummies

    CERN Document Server

    Morgan, John

    2012-01-01

    Maximize the quality and efficiency of your organization If you want to make your organization or team more productive, you have to change the way it thinks. Combining the leading improvement methods of Six Sigma and Lean, this winning technique drives performance to the next level. But the jargon-packed language and theory of Lean Six Sigma can be intimidating for both beginners and experienced users. Whether you want to manage a project more tightly or fine-tune existing systems and processes, Lean Six Sigma For Dummies gives you plain-English guidance to achieve your business goals. Lean Si

  12. Spectra of coset sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Candu, Constantin [Institut fuer Theoretische Physik, Zuerich (Switzerland); Mitev, Vladimir [Humboldt-Universitaet, Berlin (Germany). Inst. fuer Mathematik; Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik; Schomerus, Volker [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group

    2013-08-15

    We compute the complete 1-loop spectrum of anomalous dimensions for the bulk fields of non-linear sigma models on symmetric coset (super)spaces G/H, both with and without world-sheet supersymmetry. In addition, we provide two new methods for the construction of partition functions in the infinite radius limit and demonstrate their efficiency in the case of (super)sphere sigma models. Our results apply to a large number of target spaces including superspheres and superprojective spaces such as the N=2 sigma model on CP{sup 3} {sup vertical} {sup stroke} {sup 4}.

  13. Computing system failure probabilities: a comparison of SIGMA PI with other methods

    Energy Technology Data Exchange (ETDEWEB)

    Thatcher, R.M.; Corynen, G.C.

    1985-08-01

    SIGMA PI is the fastest method available today of accurately calculating probabilities associated with large fault trees. To demonstrate this, we describe the major problems that have prevented successful evaluation of these probabilities by other methods in the past. Then, we describe how SIGMA PI addresses all of these problems, and we compare the performance of SIGMA PI with that of leading alternative methods under selected problem scenarios. 13 refs., 3 figs., 2 tabs.

  14. Wideband Sigma-Delta Modulators

    OpenAIRE

    Yuan, Xiaolong

    2010-01-01

    Sigma-delta modulators (SDM) have come up as an attractive candidatefor analog-to-digital conversion in single chip front ends thanks to the continuousimproving performance. The major disadvantage is the limited bandwidthdue to the need of oversampling. Therefore, extending these convertersto broadband applications requires lowering the oversampling ratio (OSR) inorder. The aim of this thesis is the investigation on the topology and structureof sigma-delta modulators suitable for wideband app...

  15. Coordination of RNA Polymerase II Pausing and 3' End Processing Factor Recruitment with Alternative Polyadenylation.

    Science.gov (United States)

    Fusby, Becky; Kim, Soojin; Erickson, Benjamin; Kim, Hyunmin; Peterson, Martha L; Bentley, David L

    2015-01-01

    Most mammalian genes produce transcripts whose 3' ends are processed at multiple alternative positions by cleavage/polyadenylation (CPA). Poly(A) site cleavage frequently occurs cotranscriptionally and is facilitated by CPA factor binding to the RNA polymerase II (Pol II) C-terminal domain (CTD) phosphorylated on Ser2 residues of its heptad repeats (YS2PTSPS). The function of cotranscriptional events in the selection of alternative poly(A) sites is poorly understood. We investigated Pol II pausing, CTD Ser2 phosphorylation, and processing factor CstF recruitment at wild-type and mutant IgM transgenes that use alternative poly(A) sites to produce mRNAs encoding the secreted and membrane-bound forms of the immunoglobulin (Ig) heavy chain. The results show that the sites of Pol II pausing and processing factor recruitment change depending on which poly(A) site is utilized. In contrast, the extent of Pol II CTD Ser2 phosphorylation does not closely correlate with poly(A) site selection. We conclude that changes in properties of the transcription elongation complex closely correlate with utilization of different poly(A) sites, suggesting that cotranscriptional events may influence the decision between alternative modes of pre-mRNA 3' end processing. PMID:26527620

  16. Six Sigma Project Selection Using Fuzzy TOPSIS Decision Making Approach

    Directory of Open Access Journals (Sweden)

    Rajeev Rathi

    2015-05-01

    Full Text Available Six Sigma is considered as a logical business strategy that attempts to identify and eliminate the defects or failures for improving the quality of product and processes. A decision on project selection in Six Sigma is always very critical; it plays a key role in successful implementation of Six Sigma. Selection of a right Six Sigma project is essentially important for an automotive company because it greatly influences the manufacturing costs. This paper discusses an approach for right Six Sigma project selection at an automotive industry using fuzzy logic based TOPSIS method. The fuzzy TOPSIS is a well recognized tool to undertake the fuzziness of the data involved in choosing the right preferences. In this context, evaluation criteria have been designed for selection of best alternative. The weights of evaluation criteria are calculated by using the MDL (modified digital logic method and final ranking is calculated through priority index obtained by using fuzzy TOPSIS method. In the selected case study, this approach has rightly helped to identify the right project for implementing Six Sigma for achieving improvement in productivity.

  17. Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

    Science.gov (United States)

    Caceres, Javier F.; Stamm, Stefan; Helfman, David M.; Krainer, Adrian R.

    1994-09-01

    The opposing effects of SF2/ASF and heterogeneous nuclear ribonucleoprotein (hnRNP) A1 influence alternative splicing in vitro. SF2/ASF or hnRNP A1 complementary DNAs were transiently overexpressed in HeLa cells, and the effect on alternative splicing of several cotransfected reporter genes was measured. Increased expression of SF2/ASF activated proximal 5' splice sites, promoted inclusion of a neuron-specific exon, and prevented abnormal exon skipping. Increased expression of hnRNP A1 activated distal 5' splice sites. Therefore, variations in the intracellular levels of antagonistic splicing factors influence different modes of alternative splicing in vivo and may be a natural mechanism for tissue-specific or developmental regulation of gene expression.

  18. Running Head: Implementing Six Sigma Efforts

    Science.gov (United States)

    Lindsay, Jamie Eleaitia Mae

    2005-01-01

    Six Sigma is an organization wide program that provides common set of goals, language, and methodology for improving the overall quality of the processes within the organization (Davis & Heineke 2004). Six Sigma main concern is for the customer. What will the customers want? Need? Six Sigma has a model that helps Sigma get implemented DMAIC model…

  19. Synergy of fuzzy AHP and Six Sigma for capacity waste management in Indian automotive industry

    Directory of Open Access Journals (Sweden)

    Rajeev Rathi

    2015-07-01

    Full Text Available Capacity waste management is highly essential because under utilization of capacity is often referred to as a major reason for lower productivity among industries around the world. For better estimation of capacity and its utilization and then for its improved management; newer techniques are being devised in industrial sector. The current case of capacity waste problem has been taken up as a Six Sigma project, where we try to analyze critical factors responsible for the capacity waste. Decisions on critical factor selection in analysis phase of Six Sigma are always very crucial. The paper discusses an approach for selection of capacity waste factors at an automotive industry using fuzzy logic based AHP method. The fuzzy AHP is a well recognized tool to undertake the fuzziness of the data involved in choosing the preferences of the different decision variables engaged in the process of capacity waste factors selection. In this context, we have explored six crucial parameters for selection of capacity waste factors. Final ranking is calculated through priority vector thus obtained and it is seen that conveyor malfunction is found to be the key factor for capacity waste among all alternatives at the selected site.

  20. Alternative complement pathway and factor B activities in rats with altered blood levels of thyroid hormone

    Energy Technology Data Exchange (ETDEWEB)

    Bitencourt, C.S. [Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil); Duarte, C.G.; Azzolini, A.E.C.S.; Assis-Pandochi, A.I. [Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP (Brazil)

    2012-03-02

    Evaluating the activity of the complement system under conditions of altered thyroid hormone levels might help elucidate the role of complement in triggering autoimmune processes. Here, we investigated alternative pathway (AP) activity in male Wistar rats (180 ± 10 g) after altering their thyroid hormone levels by treatment with triiodothyronine (T3), propylthiouracil (PTU) or thyroidectomy. T3 and thyroxine (T4) levels were determined by chemiluminescence assays. Hemolytic assays were performed to evaluate the lytic activity of the AP. Factor B activity was evaluated using factor B-deficient serum. An anti-human factor B antibody was used to measure factor B levels in serum by radial immunodiffusion. T3 measurements in thyroidectomized animals or animals treated with PTU demonstrated a significant reduction in hormone levels compared to control. The results showed a reduction in AP lytic activity in rats treated with increasing amounts of T3 (1, 10, or 50 µg). Factor B activity was also decreased in the sera of hyperthyroid rats treated with 1 to 50 µg T3. Additionally, treating rats with 25 µg T3 significantly increased factor B levels in their sera (P < 0.01). In contrast, increased factor B concentration and activity (32%) were observed in hypothyroid rats. We conclude that alterations in thyroid hormone levels affect the activity of the AP and factor B, which may in turn affect the roles of AP and factor B in antibody production.

  1. Transition probabilities of the B-prime 1Sigma(u)(+) to X 1Sigma(g)(+) system of molecular hydrogen

    Science.gov (United States)

    Kwok, T. L.; Dalgarno, A.; Posen, A.

    1985-01-01

    From published potential energy curves and transition dipole moments, there are obtained by numerical integration of the equations of nuclear motion the vibrational eigenfunctions of the X 1Sigma(g)(+) and B-prime 1Sigma(u)(+) states of H2. The probabilities of radiative transitions from the discrete vibrational levels of the excited B-prime 1Sigma(u)(+) electronic state of H2 to the discrete and continuum vibrational levels of the ground X 1Sigma(g)(+) electronic state are calculated. The Franck-Condon factors are also presented.

  2. The SIGMA plants economic behavior

    International Nuclear Information System (INIS)

    In this work, the economical behavior of the Uranium Enrichment Plants, built using the Gaseous Isotopic Separation using Advanced Methods (SIGMA) (Separacion Isotopica Gaseosa por Metodos Avanzados) technology is analyzed. The calculations were made using an integrated computer code, where the cost of each main component of the plant is estimated. The program computes the production cost for several configurations of enrichment cascades, each one corresponding to a production rate. The program also includes a numerical optimizer and it seeks the SIGMA optimal configuration for a given set of design parameters. The present work does not contemplate the model and calculation of the auxiliary system costs. The total amortization cost is obtained by using the cascade capital cost and assuming that the auxiliary system represents a fixed part of the total cost.The results obtained show that the SIGMA technology for Enrichment Uranium Plants could achieve economical competition in a much lower production scale than the conventional Gaseous Diffusion Enrichment Plants. (author)

  3. Alternative management structures for municipal waste collection services: The influence of economic and political factors

    Energy Technology Data Exchange (ETDEWEB)

    Plata-Díaz, Ana María, E-mail: amplata@ugr.es; Zafra-Gómez, José Luis, E-mail: jlzafra@ugr.es; Pérez-López, Gemma, E-mail: gemmapl@ugr.es; López-Hernández, Antonio Manuel, E-mail: alopezh@ugr.es

    2014-11-15

    Highlights: • We analyzed the factors that influence on the restructuring of MSW services. • We evaluated five different alternatives for public and private service. • Our analysis covers a broad time horizon, 2002–2010. • We used a conditional fixed-effects logistic regression as the evaluation method. • Municipalities tend to contract out the MSW service in the presence of high costs and fiscal stress. - Abstract: Identifying and characterising the factors that determine why a local authority opts for a particular way of managing its waste collection service is an important issue, warranting research interest in the field of municipal solid waste (MSW) management. This paper presents empirical evidence spanning a broad time horizon (2002–2010) showing that economic and political factors impact in different ways on the provision of waste management services. We examine five alternatives in this area, including public and private service delivery formulas and, within each field, individual and joint options. Our findings highlight the importance of the service cost and that of the various indicators of fiscal stress as determinant factors of management decisions regarding the provision of MSW management services.

  4. Alternative management structures for municipal waste collection services: The influence of economic and political factors

    International Nuclear Information System (INIS)

    Highlights: • We analyzed the factors that influence on the restructuring of MSW services. • We evaluated five different alternatives for public and private service. • Our analysis covers a broad time horizon, 2002–2010. • We used a conditional fixed-effects logistic regression as the evaluation method. • Municipalities tend to contract out the MSW service in the presence of high costs and fiscal stress. - Abstract: Identifying and characterising the factors that determine why a local authority opts for a particular way of managing its waste collection service is an important issue, warranting research interest in the field of municipal solid waste (MSW) management. This paper presents empirical evidence spanning a broad time horizon (2002–2010) showing that economic and political factors impact in different ways on the provision of waste management services. We examine five alternatives in this area, including public and private service delivery formulas and, within each field, individual and joint options. Our findings highlight the importance of the service cost and that of the various indicators of fiscal stress as determinant factors of management decisions regarding the provision of MSW management services

  5. Emission factors for vehicles propelled by fossil or alternative fuels. Main report

    International Nuclear Information System (INIS)

    The aim of the project was to develop emission factors for commercial and alternative fuels such as alcohols and methane. The background to the decision to carry out the project was that there was a need for emission factors for some other KFB projects organized within the 'system study' carried out by KFB. The method used for the project was to use the today's emission levels and the knowledge about the emission control technology as a base for the estimation of future emission levels and the coming development of vehicles and the emission control technology. The results of the analysis and the estimation show that there exists a positive development concerning emission control technology and emission levels. However, the future positive development for alternative fuels strongly depends on the possibility of these fuels to capture a market which will have certain impact on the willingness and the economic possibilities of the car manufacturers to also invest in the development of alternative fuels. 70 refs

  6. Spectra of conformal sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Tlapak, Vaclav

    2015-04-15

    In this thesis the spectra of conformal sigma models defined on (generalized) symmetric spaces are analysed. The spaces where sigma models are conformal without the addition of a Wess-Zumino term are supermanifolds, in other words spaces that include fermionic directions. After a brief review of the general construction of vertex operators and the background field expansion, we compute the diagonal terms of the one-loop anomalous dimensions of sigma models on semi-symmetric spaces. We find that the results are formally identical to the symmetric case. However, unlike for sigma models on symmetric spaces, off diagonal terms that lead to operator mixing are also present. These are not computed here. We then present a detailed analysis of the one-loop spectrum of the supersphere S{sup 3} {sup vertical} {sup stroke} {sup 2} sigma model as one of the simplest examples. The analysis illustrates the power and simplicity of the construction. We use this data to revisit a duality with the OSP(4 vertical stroke 2) Gross-Neveu model that was proposed by Candu and Saleur. With the help of a recent all-loop result for the anomalous dimension of (1)/(2)BPS operators of Gross-Neveu models, we are able to recover the entire zero-mode spectrum of the supersphere model. We also argue that the sigma model constraints and its equations of motion are implemented correctly in the Gross-Neveu model, including the one-loop data. The duality is further supported by a new all-loop result for the anomalous dimension of the ground states of the sigma model. However, higher-gradient operators cannot be completely recovered. It is possible that this discrepancy is related to a known instability of the sigma model. The instability of sigma models is due to symmetry preserving high-gradient operators that become relevant at arbitrarily small values of the coupling. This feature has been observed long ago in one-loop calculations of the O(N)-vector model and soon been realized to be a generic

  7. THE IMPLEMENTATION OF SIX SIGMA IN MANUFACTURING ORGANIZATIONS: MOTIVATIONS AND RESULTS ACHIEVED

    Directory of Open Access Journals (Sweden)

    Antônio Domingos Padula

    2005-12-01

    Full Text Available The competitive context forces organizations to choose improvement tools that yield maximum efficiency from their operations. There are many articles about Six Sigma in the technical literature but academic research is not so abundant. This research aims at evaluating how Six Sigma implementation takes place and identifies critical success factors, by analyzing six industrial organizations which have already adopted Six Sigma. The results show convergence between organizations and aspects that maximize gains beyond those publicized on Six Sigma methodology. The research concludes that adherence to the methodology, support from Upper Management and alignment with other initiatives are critical success factors.

  8. IMPLEMENTING SIX SIGMA TO IMPROVE HOSPITAL DISCHARGE PROCESS

    Directory of Open Access Journals (Sweden)

    Kirti Udayai* and Piyush Kumar

    2012-11-01

    Full Text Available Privatizations of health care have changed the functioning and demand of health care system. As today's competitive environment leaves no scope for error, we need to delight our patients, look for new ways to exceed their expectations on continuous basis, with a focus on improvement in technical skills, human skills and to develop cost effective methodologies. To meet challenges, implementation of six sigma is the utmost solution. The concept is still in its nascent stage in Indian health care system. Six sigma is a scientific concept, provides measurement of every activity in the hospital by using various statistical tools. Alternatively delay in discharge of patients was a chronic problem among Indian Hospitals. Good discharge management is vital to ensure patient satisfaction; bed availability for emergency and elective admissions; and quality of patient care remains high. This paper attempts to study six sigma aspects in the discharge process of a corporate hospital.

  9. Structural analysis of sigma E interactions with core RNA polymerase and its cognate P-hsp20 promoter of Mycobacterium tuberculosis.

    Science.gov (United States)

    Gupta, Aayatti Mallick; Pal, Purab; Mandal, Sukhendu

    2016-04-01

    Alternate sigma factor plays an important role for the survival of Mycobacterium tuberculosis in adverse environmental condition. Stress-induced sigma factors are major cause for expression of genes involved in pathogenesis, dormancy and various unusual environmental conditions. In the present work, an attempt has been made to characterize one of such M. tuberculosis (Mtb) sigma factor, SigE. The structures of Mtb-SigE and Mtb-β have been predicted using comparative modelling techniques and validated. Effort has also been implied to understand the nature of interaction of SigE with the core RNA polymerase subunits which have well identified the amino acid residues in the binding interface and prompted the fact that Mtb-β' and Mtb-β interact with domain 2 and domain 4 of Mtb-SigE, respectively. Furthermore, intermolecular docking study predicted the interface between the Mtb-SigE and its putative promoter P-hsp20. The report confers the probable amino acid residues and the nitrogenous bases involved in the recognition of P-hsp20 by the sigma factor to initiate the transcription process. PMID:26006066

  10. Confirmatory Factor Analysis of the Structure of Statistics Anxiety Measure: An Examination of Four Alternative Models

    Directory of Open Access Journals (Sweden)

    Hossein Bevrani, PhD

    2011-09-01

    Full Text Available Objective: The aim of this study is to explore the confirmatory factor analysis results of the Persian adaptation of Statistics Anxiety Measure (SAM, proposed by Earp.Method: The validity and reliability assessments of the scale were performed on 298 college students chosen randomly from Tabriz University in Iran. Confirmatory factor analysis (CFA was carried out to determine the factor structures of the Persian adaptation of SAM.Results: As expected, the second order model provided a better fit to the data than the three alternative models. Conclusions: Hence, SAM provides an equally valid measure for use among college students. The study both expands and adds support to the existing body of math anxiety literature.

  11. Seis Sigma: Fatores Críticos de Sucesso para sua Implantação

    Directory of Open Access Journals (Sweden)

    Antonio Cesar Amaru Maximiano

    2009-10-01

    Full Text Available This article describes an investigation of critical success factors to implement Six Sigma in organizations operating in the Brazilian market place. Besides that, a secondary objective was to investigate the relationship between aspects like success perception among those companies which implemented Six Sigma, company size, company nationality, time of Six Sigma of implementation, continuous training, communication level between professionals, full-time and part-time Black Belts, project completion, project duration and project savings. Data were collected through an Internet questionnaire, distributed by email and sent to discussion groups involving Six Sigma professionals. Questionnaire development included a literature review and interviews with experienced Six Sigma professionals. The results indicated eight critical success factors for Six Sigma implementation: (a Leadership, (b Projects, (c Training, (d Communication and Review, (e Managerial Process, (f Black Belts Profile, (g Project Teams and (h Previous Quality Initiatives.

  12. Alternative pre-mRNA splicing in Drosophila spliceosomal assembly factor RNP-4F during development.

    Science.gov (United States)

    Fetherson, Rebecca A; Strock, Stephen B; White, Kristen N; Vaughn, Jack C

    2006-04-26

    The 5'- and 3'-UTR regions in pre-mRNAs play a variety of roles in controlling eukaryotic gene expression, including translational modulation. Here we report the results of a systematic study of alternative splicing in rnp-4f, which encodes a Drosophila spliceosomal assembly factor. We show that most of the nine introns are constitutively spliced, but several patterns of alternative splicing are observed in two pre-mRNA regions including the 5'-UTR. Intron V is shown to be of recent evolutionary origin and is infrequently spliced, resulting in generation of an in-frame stop codon and a predicted truncated protein lacking a nuclear localization signal, so that alternative splicing regulates its subcellular localization. Intron 0, located in the 5'-UTR, is subject to three different splicing decisions in D. melanogaster. Northern analysis of poly(A+) mRNAs reveals two differently sized rnp-4f mRNA isoforms in this species. A switch in relative isoform abundance occurs during mid-embryo stages, when the larger isoform becomes more abundant. This isoform is shown to represent intron 0 unspliced mRNA, whereas the smaller transcript represents the product of alternative splicing. Comparative genomic analysis predicts that intron 0 is present in diverse Drosophila species. Intron 0 splicing results in loss of an evolutionarily conserved stem-loop constituting a potential cis-regulatory element at the 3'-splice site. A model is proposed for the role of this element both in 5'-UTR alternative splicing decisions and in RNP-4F translational modulation. Preliminary evidences in support of our model are discussed.

  13. Machine Process Capability Information Through Six Sigma

    Energy Technology Data Exchange (ETDEWEB)

    Lackner, M.F.

    1998-03-13

    A project investigating details concerning machine process capability information and its accessibility has been conducted. The thesis of the project proposed designing a part (denoted as a machine capability workpiece) based on the major machining features of a given machine. Parts are machined and measured to gather representative production, short-term variation. The information is utilized to predict the expected defect rate, expressed in terms of a composite sigma level process capability index, for a production part. Presently, decisions concerning process planning, particularly what machine will statistically produce the minimum amount of defects based on machined features and associated tolerances, are rarely made. Six sigma tools and methodology were employed to conduct this investigation at AlliedSignal FM and T. Tools such as the thought process map, factor relationship diagrams, and components of variance were used. This study is progressing toward completion. This research study was an example of how machine process capability information may be gathered for milling planar faces (horizontal) and slot features. The planning method used to determine where and how to gather variation for the part to be designed is known as factor relationship diagramming. Components-of-variation is then applied to the gathered data to arrive at the contributing level of variation illustrated within the factor relationship diagram. The idea of using this capability information beyond process planning to the other business enterprise operations is proposed.

  14. Over-Reporting in Handwashing Self-Reports: Potential Explanatory Factors and Alternative Measurements.

    Directory of Open Access Journals (Sweden)

    Nadja Contzen

    Full Text Available Handwashing interventions are a priority in development and emergency aid programs. Evaluation of these interventions is essential to assess the effectiveness of programs; however, measuring handwashing is quite difficult. Although observations are considered valid, they are time-consuming and cost-ineffective; self-reports are highly efficient but considered invalid because desirable behaviour tends to be over-reported. Socially desirable responding has been claimed to be the main cause of inflated self-reports, but its underlying factors and mechanisms are understudied. The present study investigated socially desirable responding and additional potential explanatory factors for over-reported handwashing to identify indications for measures which mitigate over-reporting. Additionally, a script-based covert recall, an alternative interview question intended to mitigate recall errors and socially desirable responding, was developed and tested. Cross-sectional data collection was conducted in the Borena Zone, Ethiopia, through 2.5-hour observations and 1-hour interviews with the primary caregivers in households. A total sample of N = 554 was surveyed. Data were analysed with correlation and multiple regression analyses and dependent t-tests. Over-reporting of handwashing was associated with factors assumed to be involved in (1 socially desirable responding, (2 encoding and recall of information, and (3 dissonance processes. The latter two factor groups explained over-reported handwashing beyond socially desirable responding. The alternative interview question--script-based covert recall--reduced over-reporting compared to conventional self-reports. Although the difficulties involved in measuring handwashing by self-reports and observations are widely known, the present study is the first to investigate the factors which explain over-reporting of handwashing. This research contributes to the limited evidence base on a highly important subject: how

  15. Over-Reporting in Handwashing Self-Reports: Potential Explanatory Factors and Alternative Measurements.

    Science.gov (United States)

    Contzen, Nadja; De Pasquale, Sandra; Mosler, Hans-Joachim

    2015-01-01

    Handwashing interventions are a priority in development and emergency aid programs. Evaluation of these interventions is essential to assess the effectiveness of programs; however, measuring handwashing is quite difficult. Although observations are considered valid, they are time-consuming and cost-ineffective; self-reports are highly efficient but considered invalid because desirable behaviour tends to be over-reported. Socially desirable responding has been claimed to be the main cause of inflated self-reports, but its underlying factors and mechanisms are understudied. The present study investigated socially desirable responding and additional potential explanatory factors for over-reported handwashing to identify indications for measures which mitigate over-reporting. Additionally, a script-based covert recall, an alternative interview question intended to mitigate recall errors and socially desirable responding, was developed and tested. Cross-sectional data collection was conducted in the Borena Zone, Ethiopia, through 2.5-hour observations and 1-hour interviews with the primary caregivers in households. A total sample of N = 554 was surveyed. Data were analysed with correlation and multiple regression analyses and dependent t-tests. Over-reporting of handwashing was associated with factors assumed to be involved in (1) socially desirable responding, (2) encoding and recall of information, and (3) dissonance processes. The latter two factor groups explained over-reported handwashing beyond socially desirable responding. The alternative interview question--script-based covert recall--reduced over-reporting compared to conventional self-reports. Although the difficulties involved in measuring handwashing by self-reports and observations are widely known, the present study is the first to investigate the factors which explain over-reporting of handwashing. This research contributes to the limited evidence base on a highly important subject: how to evaluate

  16. Predicting $D \\to \\sigma\\pi$

    CERN Document Server

    Gatto, R; Polosa, Antonio; Törnqvist, N A

    2000-01-01

    We examine the D -> sigma pi amplitude through a constituent quark-meson model, incorporating heavy quark and chiral symmetries, finding a good agreement with the recent E791 data analysis of D -> 3 pi via sigma.

  17. Bayesian Factor Analysis as a Variable-Selection Problem: Alternative Priors and Consequences.

    Science.gov (United States)

    Lu, Zhao-Hua; Chow, Sy-Miin; Loken, Eric

    2016-01-01

    Factor analysis is a popular statistical technique for multivariate data analysis. Developments in the structural equation modeling framework have enabled the use of hybrid confirmatory/exploratory approaches in which factor-loading structures can be explored relatively flexibly within a confirmatory factor analysis (CFA) framework. Recently, Muthén & Asparouhov proposed a Bayesian structural equation modeling (BSEM) approach to explore the presence of cross loadings in CFA models. We show that the issue of determining factor-loading patterns may be formulated as a Bayesian variable selection problem in which Muthén and Asparouhov's approach can be regarded as a BSEM approach with ridge regression prior (BSEM-RP). We propose another Bayesian approach, denoted herein as the Bayesian structural equation modeling with spike-and-slab prior (BSEM-SSP), which serves as a one-stage alternative to the BSEM-RP. We review the theoretical advantages and disadvantages of both approaches and compare their empirical performance relative to two modification indices-based approaches and exploratory factor analysis with target rotation. A teacher stress scale data set is used to demonstrate our approach. PMID:27314566

  18. Bayesian Factor Analysis as a Variable-Selection Problem: Alternative Priors and Consequences.

    Science.gov (United States)

    Lu, Zhao-Hua; Chow, Sy-Miin; Loken, Eric

    2016-01-01

    Factor analysis is a popular statistical technique for multivariate data analysis. Developments in the structural equation modeling framework have enabled the use of hybrid confirmatory/exploratory approaches in which factor-loading structures can be explored relatively flexibly within a confirmatory factor analysis (CFA) framework. Recently, Muthén & Asparouhov proposed a Bayesian structural equation modeling (BSEM) approach to explore the presence of cross loadings in CFA models. We show that the issue of determining factor-loading patterns may be formulated as a Bayesian variable selection problem in which Muthén and Asparouhov's approach can be regarded as a BSEM approach with ridge regression prior (BSEM-RP). We propose another Bayesian approach, denoted herein as the Bayesian structural equation modeling with spike-and-slab prior (BSEM-SSP), which serves as a one-stage alternative to the BSEM-RP. We review the theoretical advantages and disadvantages of both approaches and compare their empirical performance relative to two modification indices-based approaches and exploratory factor analysis with target rotation. A teacher stress scale data set is used to demonstrate our approach.

  19. Grasses use an alternatively wired bHLH transcription factor network to establish stomatal identity.

    Science.gov (United States)

    Raissig, Michael T; Abrash, Emily; Bettadapur, Akhila; Vogel, John P; Bergmann, Dominique C

    2016-07-19

    Stomata, epidermal valves facilitating plant-atmosphere gas exchange, represent a powerful model for understanding cell fate and pattern in plants. Core basic helix-loop-helix (bHLH) transcription factors regulating stomatal development were identified in Arabidopsis, but this dicot's developmental pattern and stomatal morphology represent only one of many possibilities in nature. Here, using unbiased forward genetic screens, followed by analysis of reporters and engineered mutants, we show that stomatal initiation in the grass Brachypodium distachyon uses orthologs of stomatal regulators known from Arabidopsis but that the function and behavior of individual genes, the relationships among genes, and the regulation of their protein products have diverged. Our results highlight ways in which a kernel of conserved genes may be alternatively wired to produce diversity in patterning and morphology and suggest that the stomatal transcription factor module is a prime target for breeding or genome modification to improve plant productivity. PMID:27382177

  20. Grasses use an alternatively wired bHLH transcription factor network to establish stomatal identity

    Science.gov (United States)

    Raissig, Michael T.; Abrash, Emily; Bettadapur, Akhila; Bergmann, Dominique C.

    2016-01-01

    Stomata, epidermal valves facilitating plant–atmosphere gas exchange, represent a powerful model for understanding cell fate and pattern in plants. Core basic helix–loop–helix (bHLH) transcription factors regulating stomatal development were identified in Arabidopsis, but this dicot’s developmental pattern and stomatal morphology represent only one of many possibilities in nature. Here, using unbiased forward genetic screens, followed by analysis of reporters and engineered mutants, we show that stomatal initiation in the grass Brachypodium distachyon uses orthologs of stomatal regulators known from Arabidopsis but that the function and behavior of individual genes, the relationships among genes, and the regulation of their protein products have diverged. Our results highlight ways in which a kernel of conserved genes may be alternatively wired to produce diversity in patterning and morphology and suggest that the stomatal transcription factor module is a prime target for breeding or genome modification to improve plant productivity. PMID:27382177

  1. Lean Six Sigma in financial services

    NARCIS (Netherlands)

    H. de Koning; R.J.M.M. Does; S. Bisgaard

    2008-01-01

    Lean Thinking and Six Sigma are typically considered as separate approaches to process innovation, with complementary strengths. When combined as Lean Six Sigma, this approach provides a unified framework for systematically developing innovations. Lean Six Sigma can also bring about significant resu

  2. The C-Terminal RpoN Domain of sigma54 Forms an unpredictedHelix-Turn-Helix Motif Similar to domains of sigma70

    Energy Technology Data Exchange (ETDEWEB)

    Doucleff, Michaeleen; Malak, Lawrence T.; Pelton, Jeffrey G.; Wemmer, David E.

    2005-11-01

    The ''{delta}'' subunit of prokaryotic RNA-polymerase allows gene-specific transcription initiation. Two {sigma} families have been identified, {sigma}{sup 70} and {sigma}{sup 54}, which use distinct mechanisms to initiate transcription and share no detectable sequence homology. Although the {sigma}{sup 70}-type factors have been well characterized structurally by x-ray crystallography, no high-resolution structural information is available for the {sigma}{sup 54}-type factors. Here we present the NMR derived structure of the C-terminal domain of {sigma}{sup 54} from Aquifex aeolicus. This domain (Thr323 to Gly389), which contains the highly conserved RpoN box sequence, consists of a poorly structured N-terminal tail followed by a three-helix bundle, which is surprisingly similar to domains of the {sigma}{sup 70}-type proteins. Residues of the RpoN box, which have previously been shown to be critical for DNA binding, form the second helix of an unpredicted helix-turn-helix motif. This structure's homology with other DNA binding proteins, combined with previous biochemical data, suggest how the C-terminal domain of {sigma}{sup 54} binds to DNA.

  3. Some Practical Issues in the Application of Lean Six Sigma to Service Systems

    Directory of Open Access Journals (Sweden)

    Goh Thong-Ngee

    2014-11-01

    Full Text Available Six Sigma as a quality improvement framework has gained considerable popularity in the past two decades. Its extension Lean Six Sigma has also been embraced by many organizations for improvement of quality and business competitiveness. One important factor for the popularity of Six Sigma and Lean Six Sigma is their potential for improving service systems, in contrast to the conventional perceptions that only manufacturing systems can benefit from statistics-based methodologies. There are however a number of issues related to the nature of service systems that must be resolved before the full benefits of Lean Six Sigma can be realized. In this paper, these issues are discussed from a practical point of view from three angles: analytical, organizational, and personal. Awareness of the existence of such issues, if not the answers to all of them, is a pre-requisite to effective adoption of Lean Six Sigma tools.

  4. Human factors evaluation of teletherapy: Identification of problems and alternative approaches. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Henriksen, K.; Kaye, R.D.; Jones, R. [Hughes Training, Inc., Falls Church, VA (United States); Morisseau, D.S.; Serig, D.I. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Systems Technology

    1995-07-01

    A series of human factors evaluations was undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multi-disciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. The principal sources of radiation are a radioactive isotope, typically cobalt60 (Co-60), or a linear accelerator device capable of producing very high energy x-ray and electron beams. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of user-system interfaces, procedures, training and qualifications, and organizational policies and practices. The final phase of the project focused on identification of the most significant human factors problems with respect to safe and effective operation of the teletherapy system and an identification and assessment of alternative approaches for resolving the problems. This report presents the findings of this final phase.

  5. Human factors evaluation of teletherapy: Identification of problems and alternative approaches. Volume 1

    International Nuclear Information System (INIS)

    A series of human factors evaluations was undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multi-disciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. The principal sources of radiation are a radioactive isotope, typically cobalt60 (Co-60), or a linear accelerator device capable of producing very high energy x-ray and electron beams. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation technologists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was initially performed to guide subsequent evaluations in the areas of user-system interfaces, procedures, training and qualifications, and organizational policies and practices. The final phase of the project focused on identification of the most significant human factors problems with respect to safe and effective operation of the teletherapy system and an identification and assessment of alternative approaches for resolving the problems. This report presents the findings of this final phase

  6. Factors Associated With Complementary and Alternative Medicine Use in Irritable Bowel Syndrome: A Literature Review

    Directory of Open Access Journals (Sweden)

    Lee Usher

    2013-11-01

    Full Text Available Aim: Irritable Bowel Syndrome (IBS is a chronic functional bowel condition, which has substantial impact on quality of life and use of healthcare services. Patients often report using complementary and alternative medicine (CAM for symptom management despite limited evidence to support its use. Psychological factors have been shown to be important in both influencing CAM use and as avenues of intervention to assist in managing IBS symptoms. Therefore, this review assessed prevalence of and psychological factors associated with CAM use by people with IBS. Method: Five electronic databases (including AMED, EMBASE and PsychINFO were searched for studies that examined both the extent of and the reasons for CAM use. Five studies met the inclusion criteria. Results: Prevalence of CAM use ranged from 9% to 38%. CAM use was associated with psychosocial factors, including concerns about conventional medical care (i.e., the perceived harmful effects of medication, perception that conventional medicine had failed, and lack of satisfaction with conventional care and anxiety. Conclusion: These findings identify psychological factors associated with CAM use which could be targeted through psychologically oriented management strategies for those affected with IBS.

  7. The sausage sigma model revisited

    Science.gov (United States)

    Suneeta, Vardarajan

    2015-06-01

    Fateev’s sausage sigma models in two and three dimensions are known to be integrable. We study their stability under renormalization group (RG) flow in the target space by using results from the mathematics of Ricci flow. We show that the three-dimensional sausage is unstable, whereas the two-dimensional sausage appears to be stable at least at leading order as it approaches the sphere. We speculate that the stability results obtained are linked to the classification of ancient solutions to Ricci flow (i.e., sigma models that are nonperturbative in the infrared regime) in two and three dimensions. We also describe a class of perturbations of the three-dimensional sausage (with the same continuous symmetries) which remarkably decouple. This indicates that there could be a new solution to RG flow, which is described at least perturbatively as a deformation of the sausage.

  8. The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness (AHR) and Inflammation

    OpenAIRE

    Takeda, Katsuyuki; Thurman, Joshua M.; Tomlinson, Stephen; Okamoto, Masakazu; Shiraishi, Yoshiki; Ferreira, Viviana P.; Cortes, Claudio; Pangburn, Michael K.; Holers, V. Michael; Gelfand, Erwin W.

    2011-01-01

    Activation of the alternative pathway of complement plays a critical role in the development of allergen-induced airway hyperresponsiveness (AHR) and inflammation in mice. Endogenous factor H, a potent inhibitor of the alternative pathway, is increased in the airways of sensitized and challenged mice, but its role in regulating inflammation or AHR has been unknown. We found that blocking the tissue-binding function of factor H with a competitive antagonist increased complement activation and ...

  9. Lean six sigma in healthcare.

    Science.gov (United States)

    de Koning, Henk; Verver, John P S; van den Heuvel, Jaap; Bisgaard, Soren; Does, Ronald J M M

    2006-01-01

    Healthcare, as with any other service operation, requires systematic innovation efforts to remain competitive, cost efficient, and up-to-date. This article outlines a methodology and presents examples to illustrate how principles of Lean Thinking and Six Sigma can be combined to provide an effective framework for producing systematic innovation efforts in healthcare. Controlling healthcare cost increases, improving quality, and providing better healthcare are some of the benefits of this approach.

  10. Topological Sigma Models On Supermanifolds

    CERN Document Server

    Jia, Bei

    2016-01-01

    This paper concerns constructing topological sigma models governing maps from semirigid super Riemann surfaces to general target supermanifolds. We define both the A model and B model in this general setup by defining suitable BRST operators and physical observables. Using supersymmetric localization, we express correlation functions in these theories as integrals over suitable supermanifolds. In the case of the A model, we obtain an integral over the supermoduli space of "superinstantons". The language of supergeometry is used extensively throughout this paper.

  11. Pion (Kaon) and Sigma polarizabilities

    International Nuclear Information System (INIS)

    We report the results of the working group on ''Pion (Kaon) and Sigma Polarizabilities''. Interesting possibilities to measure these polarizabilities include the radiative pion photoproduction in the MAMI experiment at Mainz, as well as at the GRAAL facility (actually the latter is being considered for an experimental determination of the pion polarizabilities here for the first time), the experimental plans on Primakoff effect at FNAL, and the measurements at the Frascati Φ-factory DAΦNE. (orig.)

  12. Pion (kaon) and sigma polarizabilities

    CERN Document Server

    Bellucci, S

    1995-01-01

    We report the results of the working group on ``Pion (Kaon) and Sigma Polarizabilities''. Interesting possibilities to measure these polarizabilities include the radiative pion photoproduction in the MAMI experiment at Mainz, as well as at the GRAAL facility (actually the latter is being considered for an experimental determination of the pion polarizabilities here for the first time), the experimental plans on Primakoff effect at FNAL, and the measurements at the Frascati \\Phi-factory DA\\PhiNE.

  13. Pion (Kaon) and Sigma polarizabilities

    OpenAIRE

    Bellucci, S.

    1995-01-01

    We report the results of the working group on ``Pion (Kaon) and Sigma Polarizabilities''. Interesting possibilities to measure these polarizabilities include the radiative pion photoproduction in the MAMI experiment at Mainz, as well as at the GRAAL facility (actually the latter is being considered for an experimental determination of the pion polarizabilities here for the first time), the experimental plans on Primakoff effect at FNAL, and the measurements at the Frascati $\\Phi$-factory DA$\\...

  14. Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer.

    Directory of Open Access Journals (Sweden)

    Guo-Lin Chen

    Full Text Available The repressor element silencing transcription factor (REST is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice variant REST4 has been linked to various types of cancer. We performed a comprehensive analysis of alternative splicing (AS of REST by rapid amplification of cDNA ends and PCR amplification of cDNAs from various tissues and cell lines with specific primers. We identified 8 novel alternative exons including an alternate last exon which doubles the REST gene boundary, along with numerous 5'/3' splice sites and ends in the constitutive exons. With the combination of various splicing patterns (e.g. exon skipping and alternative usage of the first and last exons that are predictive of altered REST activity, at least 45 alternatively spliced variants of coding and non-coding mRNA were expressed in a species- and cell-type/tissue-specific manner with individual differences. By examining the repertoire of REST pre-mRNA splicing in 27 patients with kidney, liver and lung cancer, we found that all patients without exception showed differential expression of various REST splice variants between paired tumor and adjacent normal tissues, with striking cell-type/tissue and individual differences. Moreover, we revealed that exon 3 skipping, which causes no frame shift but loss of a domain essential for nuclear translocation, was affected by pioglitazone, a highly selective activator of the peroxisome proliferator-activated receptor gamma (PPARγ which contributes to cell differentiation and tumorigenesis besides its metabolic actions. Accordingly, this study demonstrates an extensive AS of REST pre-mRNA which redefines REST gene boundary and structure, along with a general but differential link between REST pre-mRNA splicing and various types of cancer. These findings advance our understanding of the complex, context-dependent regulation of

  15. The sigma Orionis substellar population

    CERN Document Server

    Barrado y Navascués, D; Mundt, R; Martín, E L; Rebolo, R; Zapatero-Osorio, M R; Bailer-Jones, C A L; Navascu\\'es, David Barrado y; Mundt, Reinhard; Mart\\'{\\i}n, Eduardo L.; Rebolo, Rafael; Osorio, Mar\\'{\\i}a Rosa Zapatero; Bailer-Jones, Coryn A.L.

    2003-01-01

    VLT/FORS spectroscopy and 2MASS near-infrared photometry, together with previously known data, have been used to establish the membership and the properties of a sample of low-mass candidate members of the sigma Orionis cluster with masses spanning from 1 Msun down to about 0.013 Msun (i.e., deuterium-burning mass limit). We have observed K-band infrared excess and remarkably intense H(alpha) emission in various cluster members, which, in addition to the previously detected forbidden emision lines and the presence of LiI in absorption at 6708 A, have allowed us to tentatively classify sigma Orionis members as classical or weak-line TTauri stars and substellar analogs. Variability of the H(alpha) line has been investigated and detected in some objects. Based on the K-band infrared excesses and the intensity of H(alpha) emission, we estimate that the minimum disk frequency of the sigma Orionis low-mass population is in the range 5-12%.

  16. The sausage sigma model revisited

    CERN Document Server

    Suneeta, Vardarajan

    2014-01-01

    Fateev's sausage sigma models in two and three dimensions are known to be integrable. We study their stability under RG flow in the target space by using results from the mathematics of Ricci flow. We show that the three dimensional sausage is unstable, whereas the two dimensional sausage appears to be stable at least at leading order as it approaches the sphere. The $n$-sphere, corresponding to the integrable O(n) sigma model, is geometrically stable and an attractor for nearby solutions to RG flow. We speculate that the stability results obtained seem to be linked to the classification of ancient solutions to Ricci flow (i.e., sigma models which are asymptotically free in the UV and nontrivial in the IR) in two and three dimensions. We also describe a class of perturbations of the three dimensional sausage (with the same continuous symmetries) which remarkably decouple. This indicates that there could be a new solution to RG flow which is described at least perturbatively as a deformation of the sausage.

  17. Visual Six Sigma Making Data Analysis Lean

    CERN Document Server

    Cox, Ian; Ramsey, Philip J

    2010-01-01

    Through Visual Six Sigma, learn what your data is telling your business. In the typical business environment of process improvement, you want simple-to-use tools that everyone can use at all levels to rapidly explore and interpret data. Visual Six Sigma: Making Data Analysis Lean helps you use your own data to drive incredible improvement within your business. Divided into three parts-background, case studies, and JMP highlights- Visual Six Sigma covers.: Six Sigma and Visual Six Sigma; A first look at JMP; Transforming pricing management; Improving white polymer manufacturing; Designing exper

  18. Alternative Splicing of Rice WRKY62 and WRKY76 Transcription Factor Genes in Pathogen Defense.

    Science.gov (United States)

    Liu, Jiqin; Chen, Xujun; Liang, Xiaoxing; Zhou, Xiangui; Yang, Fang; Liu, Jia; He, Sheng Yang; Guo, Zejian

    2016-06-01

    The WRKY family of transcription factors (TFs) functions as transcriptional activators or repressors in various signaling pathways. In this study, we discovered that OsWRKY62 and OsWRKY76, two genes of the WRKY IIa subfamily, undergo constitutive and inducible alternative splicing. The full-length OsWRKY62.1 and OsWRKY76.1 proteins formed homocomplexes and heterocomplexes, and the heterocomplex dominates in the nuclei when analyzed in Nicotiana benthamiana leaves. Transgenic overexpression of OsWRKY62.1 and OsWRKY76.1 in rice (Oryza sativa) enhanced plant susceptibility to the blast fungus Magnaporthe oryzae and the leaf blight bacterium Xanthomonas oryzae pv oryzae, whereas RNA interference and loss-of-function knockout plants exhibited elevated resistance. The dsOW62/76 and knockout lines of OsWRKY62 and OsWRKY76 also showed greatly increased expression of defense-related genes and the accumulation of phytoalexins. The ratio of full-length versus truncated transcripts changed in dsOW62/76 plants as well as in response to pathogen infection. The short alternative OsWRKY62.2 and OsWRKY76.2 isoforms could interact with each other and with full-length proteins. OsWRKY62.2 showed a reduced repressor activity in planta, and two sequence determinants required for the repressor activity were identified in the amino terminus of OsWRKY62.1. The amino termini of OsWRKY62 and OsWRKY76 splice variants also showed reduced binding to the canonical W box motif. These results not only enhance our understanding of the DNA-binding property, the repressor sequence motifs, and the negative feedback regulation of the IIa subfamily of WRKYs but also provide evidence for alternative splicing of WRKY TFs during the plant defense response. PMID:27208272

  19. An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes.

    Science.gov (United States)

    Gissi, Andrea; Gadaleta, Domenico; Floris, Matteo; Olla, Stefania; Carotti, Angelo; Novellino, Ettore; Benfenati, Emilio; Nicolotti, Orazio

    2014-01-01

    The REACH (Registration, Evaluation, Authorization and restriction of Chemicals) and BPR (Biocide Product Regulation) regulations strongly promote the use of non-animal testing techniques to evaluate chemical risk. This has renewed the interest towards alternative methods such as QSAR in the regulatory context. The assessment of Bioconcentration Factor (BCF) required by these regulations is expensive, in terms of costs, time, and laboratory animal sacrifices. Herein, we present QSAR models based on the ANTARES dataset, which is a large collection of known and verified experimental BCF data. Among the models developed, the best results were obtained from a nine-descriptor highly predictive model. This model was derived from a training set of 608 chemicals and challenged against a validation and blind set containing 152 and 76 chemicals. The model's robustness was further controlled through several validation strategies and the implementation of a multi-step approach for the applicability domain. Suitable safety margins were used to increase sensitivity. The easy interpretability of the model is ensured by the use of meaningful biokinetics descriptors. The satisfactory predictive power for external compounds suggests that the new models could represent a reliable alternative to the in vivo assay, helping the registrants to fulfill regulatory requirements in compliance with the ethical and economic necessity to reduce animal testing. PMID:24247988

  20. The Process to Estimate Economical Benefits of Six Sigma Projects

    Directory of Open Access Journals (Sweden)

    Jan Kosina

    2013-07-01

    Full Text Available This paper seeks to define the process for the continuous evaluation of the financial benefits during Six Sigma project life time. The financial criteria are critical success factors of a Six Sigma project. The process has been developed as part of the six sigma project monitoring in order to estimate proper allocation of the resources taking in account the expected project benefits as well as evaluationof real achievements. The evaluation of the finacial benefits based on the quality costs is not sufficient in the real life and has to be accomplished with key financial performance indicators of the business to visualize the results. The evaluation based on the savings seems to be too difficult especially for green belts. The early involvement of the finance department in the project definition as well as ongoing evaluation is key. The defined process has been applied to real business enviroment.

  1. The Interaction of Language-Specific and Universal Factors During the Acquisition of Morphophonemic Alternations With Exceptions.

    Science.gov (United States)

    Baer-Henney, Dinah; Kügler, Frank; van de Vijver, Ruben

    2015-09-01

    Using the artificial language paradigm, we studied the acquisition of morphophonemic alternations with exceptions by 160 German adult learners. We tested the acquisition of two types of alternations in two regularity conditions while additionally varying length of training. In the first alternation, a vowel harmony, backness of the stem vowel determines backness of the suffix. This process is grounded in substance (phonetic motivation), and this universal phonetic factor bolsters learning a generalization. In the second alternation, tenseness of the stem vowel determines backness of the suffix vowel. This process is not based in substance, but it reflects a phonotactic property of German and our participants benefit from this language-specific factor. We found that learners use both cues, while substantive bias surfaces mainly in the most unstable situation. We show that language-specific and universal factors interact in learning.

  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

    Science.gov (United States)

    Corominas, Roser; Yang, Xinping; Lin, Guan Ning; Kang, Shuli; Shen, Yun; Ghamsari, Lila; Broly, Martin; Rodriguez, Maria; Tam, Stanley; Trigg, Shelly A; Fan, Changyu; Yi, Song; Tasan, Murat; Lemmens, Irma; Kuang, Xingyan; Zhao, Nan; Malhotra, Dheeraj; Michaelson, Jacob J; Vacic, Vladimir; Calderwood, Michael A; Roth, Frederick P; Tavernier, Jan; Horvath, Steve; Salehi-Ashtiani, Kourosh; Korkin, Dmitry; Sebat, Jonathan; Hill, David E; Hao, Tong; Vidal, Marc; Iakoucheva, Lilia M

    2014-04-11

    Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. Here we introduce a new interactome mapping approach by experimentally identifying interactions between brain-expressed alternatively spliced variants of ASD risk factors. The Autism Spliceform Interaction Network reveals that almost half of the detected interactions and about 30% of the newly identified interacting partners represent contribution from splicing variants, emphasizing the importance of isoform networks. Isoform interactions greatly contribute to establishing direct physical connections between proteins from the de novo autism CNVs. Our findings demonstrate the critical role of spliceform networks for translating genetic knowledge into a better understanding of human diseases.

  3. Alternative Splicing Regulation During C. elegans Development: Splicing Factors as Regulated Targets

    OpenAIRE

    Sergio Barberan-Soler; Zahler, Alan M.

    2008-01-01

    Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect alternative splicing for 352 cassette exons and tested for changes in alternative splicing of these genes during development. We found that the microarray data predicted that 62/352 (approximately 18%) of the alternative splicing events studi...

  4. Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2

    Directory of Open Access Journals (Sweden)

    Ioannis Grammatikakis

    2016-05-01

    Full Text Available During neuronal differentiation, use of an alternative splice site on the rat telomere repeat-binding factor 2 (TRF2 mRNA generates a short TRF2 protein isoform (TRF2-S capable of derepressing neuronal genes. However, the RNA-binding proteins (RBPs controlling this splicing event are unknown. Here, using affinity pull-down analysis, we identified heterogeneous nuclear ribonucleoproteins H1 and H2(HNRNPH as RBPs specifically capable of interacting with the spliced RNA segment (exon 7 of Trf2 pre-mRNA. HNRNPH proteins prevent the production of the short isoform of Trf2 mRNA, as HNRNPH silencing selectively elevates TRF2-S levels. Accordingly, HNRNPH levels decline while TRF2-S levels increase during neuronal differentiation. In addition, CRISPR/Cas9-mediated deletion of hnRNPH2 selectively accelerates the NGF-triggered differentiation of rat pheochromocytoma cells into neurons. In sum, HNRNPH is a splicing regulator of Trf2 pre-mRNA that prevents the expression of TRF2-S, a factor implicated in neuronal differentiation.

  5. Contextual and psychological factors shaping evaluations and acceptability of energy alternatives : Integrated review and research agenda

    NARCIS (Netherlands)

    Perlaviciute, Goda; Steg, Linda

    2014-01-01

    Sustainable energy transitions will be hampered without sufficient public support. Hence, it is important to understand what drives public acceptability of (sustainable) energy alternatives. Evaluations of specific costs, including risks, and benefits of different energy alternatives have been linke

  6. Comparison of Sigma-Point and Extended Kalman Filters on a Realistic Orbit Determination Scenario

    Science.gov (United States)

    Gaebler, John; Hur-Diaz. Sun; Carpenter, Russell

    2010-01-01

    Sigma-point filters have received a lot of attention in recent years as a better alternative to extended Kalman filters for highly nonlinear problems. In this paper, we compare the performance of the additive divided difference sigma-point filter to the extended Kalman filter when applied to orbit determination of a realistic operational scenario based on the Interstellar Boundary Explorer mission. For the scenario studied, both filters provided equivalent results. The performance of each is discussed in detail.

  7. Perspectives in the use of tannins as alternative to antimicrobial growth promoter factors in poultry.

    Science.gov (United States)

    Redondo, Leandro M; Chacana, Pablo A; Dominguez, Johana E; Fernandez Miyakawa, Mariano E

    2014-01-01

    Antibiotics have been included in the formulation of feed for livestock production for more than 40 years as a strategy to improve feed conversion rates and to reduce costs. The use of antimicrobials as growth-promoting factors (AGP) in sub-therapeutic doses for long periods is particularly favorable for the selection of antimicrobial resistant microorganisms. In the last years, global concern about development of antimicrobial resistance and transference of resistance genes from animal to human strains has been rising. Removal of AGP from animal diets involves tremendous pressure on the livestock and poultry farmers, one of the main consequences being a substantial increase in the incidence of infectious diseases with the associated increase in the use of antibiotics for therapy, and concomitantly, economic cost. Therefore, alternatives to AGP are urgently needed. The challenge is to implement new alternatives without affecting the production performances of livestock and avoiding the increase of antimicrobial resistant microorganisms. Plant extracts and purified derived substances are showing promising results for animal nutrition, either from their efficacy as well as from an economical point of view. Tannins are plant derived compounds that are being successfully used as additives in poultry feed to control diseases and to improve animal performance. Successful use of any of these extracts as feed additives must ensure a product of consistent quality in enough quantity to fulfill the actual requirements of the poultry industry. Chestnut (hydrolysable) and Quebracho (condensed) tannins are probably the most readily available commercial products that are covering those needs. The present report intends to analyze the available data supporting their use. PMID:24723916

  8. Perspectives in the use of tannins as alternative to antimicrobial growth promoter factors in poultry

    Directory of Open Access Journals (Sweden)

    Leandro M Redondo

    2014-03-01

    Full Text Available Antibiotics have been included in the formulation of feed for livestock production for more than 40 years as a strategy to improve feed conversion rates and to reduce costs. The use of antimicrobials as growth-promoting factors (AGP in sub-therapeutic doses for long periods is particularly favorable to select antimicrobial-resistant microorganisms. In the last years, global concern about development of antimicrobial resistance and transference of resistance genes from animal to human strains has been arising. Removal of AGP from animal diets involves a tremendous pressure on the livestock and poultry farmers, one of the main consequences being a substantial increase in the incidence of infectious diseases with the related increase in the use of antibiotics for therapy and, concomitantly, economic cost. Therefore, alternatives to AGP are urgently needed. The challenge is to implement new alternatives without affecting the production performances of livestock and also avoiding the increase of antimicrobial resistant microorganisms. Plant extracts and purified derived substances are showing promising results for food animal production, either from their efficacy as well as from an economical point of view. Tannins are plant derived compounds that are being successfully used as additives in feed poultry to control diseases and to improve animal performance. Successful use of any of these extracts as feed additive must ensure a product of consistent quality in enough quantities to fulfill the actual requirements of the poultry industry. Chestnut (hydrolizable and Quebracho (condennsed tannins are probably the most readily available commercial products that are covering those needs. The present report intends to analyze the available data supporting their use.

  9. Perspectives in the use of tannins as alternative to antimicrobial growth promoter factors in poultry.

    Science.gov (United States)

    Redondo, Leandro M; Chacana, Pablo A; Dominguez, Johana E; Fernandez Miyakawa, Mariano E

    2014-01-01

    Antibiotics have been included in the formulation of feed for livestock production for more than 40 years as a strategy to improve feed conversion rates and to reduce costs. The use of antimicrobials as growth-promoting factors (AGP) in sub-therapeutic doses for long periods is particularly favorable for the selection of antimicrobial resistant microorganisms. In the last years, global concern about development of antimicrobial resistance and transference of resistance genes from animal to human strains has been rising. Removal of AGP from animal diets involves tremendous pressure on the livestock and poultry farmers, one of the main consequences being a substantial increase in the incidence of infectious diseases with the associated increase in the use of antibiotics for therapy, and concomitantly, economic cost. Therefore, alternatives to AGP are urgently needed. The challenge is to implement new alternatives without affecting the production performances of livestock and avoiding the increase of antimicrobial resistant microorganisms. Plant extracts and purified derived substances are showing promising results for animal nutrition, either from their efficacy as well as from an economical point of view. Tannins are plant derived compounds that are being successfully used as additives in poultry feed to control diseases and to improve animal performance. Successful use of any of these extracts as feed additives must ensure a product of consistent quality in enough quantity to fulfill the actual requirements of the poultry industry. Chestnut (hydrolysable) and Quebracho (condensed) tannins are probably the most readily available commercial products that are covering those needs. The present report intends to analyze the available data supporting their use.

  10. Lean Six Sigma in financial services

    OpenAIRE

    Koning, de, L.J.; Does, R.J.M.M.; Bisgaard, S.

    2008-01-01

    Lean Thinking and Six Sigma are typically considered as separate approaches to process innovation, with complementary strengths. When combined as Lean Six Sigma, this approach provides a unified framework for systematically developing innovations. Lean Six Sigma can also bring about significant results and breakthrough improvements in financial services, as demonstrated with four case studies from Dutch multinational insurance companies. These cases demonstrate the importance of incremental i...

  11. Pion-delta sigma-term

    OpenAIRE

    Cavalcante, I. P.; Robilotta, M. R.; Borges, J. Sa; Santos, D. de O.; Zarnauskas, G. R. S.

    2005-01-01

    We use a configuration space chiral model in order to evaluate nucleon and delta sigma-terms. Analytic expressions are consistent with chiral counting rules and give rise to expected non-analytic terms in the chiral limit. We obtain the results $\\sigma_N=46$ MeV and $\\sigma_{\\Delta}=32$ MeV, which are very close to values extracted from experiment and produced by other groups.

  12. Health, Islam and Alternative Capitalism. Three possible Key Factors in Developing Somaliland

    Directory of Open Access Journals (Sweden)

    Daria Zizzola

    2012-02-01

    Full Text Available The main aim of this paper is to investigate the socio, political and economic dynamics that have occurred in Somaliland in the last decades. Even though this country is still unrecognized by the international community, Somaliland’s economy has undertaken an enduring growth, above all in the private entrepreneurial sector. The author argues that religion has had an important role in the Somali cultural and social identification. According to this assumption, the article analyzes the Islamic factor by showing how it has led to the creation of many alternative connections supported by mutual trust and religious solidarity among involved communities. These connections are somehow fulfilling the absence of political legitimacy while progressively substituting conventional routes of intra-national negotiation, like diplomacy. To confirm this tendency, specific arguments are drawn from Somaliland’s health sector. The health care system is considered a preferential index to evaluate the level of national development. Above all, the private non-profit sector gives some evidence of the Somali capacity of running competitive private businesses while multiplying simultaneously their resources and suppliers with a consequent increase in autonomy and efficiency. This successful compromise bears the fruits of Somali engagement and can be identified by their inexhaustible adaptability to adverse conditions and their ability to avoid, not deny, the rational rules imposed by external actors and their ostensible, insurmountable interests.

  13. Morningness-eveningness, sex, and the Alternative Five Factor Model of personality.

    Science.gov (United States)

    Muro, Anna; Gomà-i-Freixanet, Montserrat; Adan, Ana

    2009-08-01

    Recent research on personality and circadian typology indicates that evening-type subjects are more extraverted, impulsive, and novelty-seeking, while morning ones tend to be more introverted, conscientious, agreeable, and emotionally stable. The purpose of this study was to examine the differences between circadian typologies on the Zuckerman's Alternative Five Factor Model of personality (AFFM), which has a strong biological basis, controlling for sex and age. A sample of 533 university students (168 men) participated in the study. Results showed that morning-type subjects had significant higher scores than evening-type and neither-type subjects in Activity, and in its subscales General Activity and Work Activity. A significant interaction between circadian typology and sex was found for Neuroticism-Anxiety: morning-type men showed higher scores than evening-type and neither-type, who had the lowest scores. Women presented the opposite pattern: neither-type obtained the highest scores, while morning-type showed the lowest. This is the first time the AFFM has been used in the context of circadian rhythms research. The results suggest that activity is the only trait related to extraversion associated with morningness, while Neuroticism-Anxiety was modulated by sex. These results might help highlight previous results on the association between morningness-eveningness and other models of personality assessment, and they offer new data that calls for further research.

  14. Circadian typology, age, and the alternative five-factor personality model in an adult women sample.

    Science.gov (United States)

    Muro, Anna; Gomà-i-Freixanet, Montserrat; Adan, Ana; Cladellas, Ramon

    2011-10-01

    Research on personality and circadian typology indicates evening-type women are more impulsive and novelty seeking, neither types are more anxious, and morning types tend to be more active, conscientious, and persistent. The purpose of this study is to examine the differences between circadian typologies in the light of the Zuckerman's Alternative Five-Factor Model (AFFM) of personality, which has a strong biological basis, in an adult sample of 412 women 18 to 55 yrs of age. The authors found morning-type women had significant higher scores than evening-type and neither-type women on Activity, and its subscales General Activity and Work Activity. In contrast, evening-type women scored significantly higher than morning-type women on Aggression-Hostility, Impulsive Sensation Seeking, and its subscale Sensation Seeking. In all groups, results were independent of age. These findings are in accordance with those previously obtained in female student samples and add new data on the AFFM. The need of using personality models that are biologically based in the study of circadian rhythms is discussed.

  15. $\\sigma$-Set Theory and the Integer Space

    CERN Document Server

    Araus, Ivan Gatica

    2009-01-01

    In this article we develop an alternative theory to the ZF Set Theory called $\\sigma$-Set Theory. The goal of this theory is to build the Integer Space $3^{X}$, that will be the algebraic completion of the Power Set $2^{X}$, i.e., $3^{X}$ contains the inverse element for the union, that in this case we call fusion. We first give an introduction where we explain in a more detailed way the motivations and the objectives of this new theory. Later we present the language of the theory that will be the same as that of the Set Theory. Finally, we present the axioms of the $\\sigma$-Set Theory and their individual analysis.

  16. Optimization of Steel Bar Manufacturing Process Using Six Sigma

    Institute of Scientific and Technical Information of China (English)

    NAEEM Khawar; ULLAH Misbah; TARIQ Adnan; MAQSOOD Shahid; AKHTAR Rehman; NAWAZ Rashid; HUSSAIN Iftikhar

    2016-01-01

    Optimization of a manufacturing process results in higher productivity and reduced wastes. Production parameters of a local steel bar manufacturing industry of Pakistan is optimized by using six Sigma-Define, measure, analyze, improve, and control- methodology. Production data is collected and analyzed. After analysis, experimental design result is used to identify significant factors affecting process performance. The significant factors are controlled to optimized level using two-level factorial design method. A regression model is developed that helps in the estimation of response under multi variable input values. Model is tested, verified, and validated by using industrial data collected at a local steel bar manufacturing industry of Peshawar(Khyber Pakhtunkhwa, Pakistan). The sigma level of the manufacturing process is improved to 4.01 from 3.58. The novelty of the research is the identification of the significant factors along with the optimum levels that affects the process yield, and the methodology to optimize the steel bar manufacturing process.

  17. Epstein-Barr Virus SM Protein Functions as an Alternative Splicing Factor

    OpenAIRE

    Verma, Dinesh; Swaminathan, Sankar

    2008-01-01

    Alternative splicing of RNA increases the coding potential of the genome and allows for additional regulatory control over gene expression. The full extent of alternative splicing remains to be defined but is likely to significantly expand the size of the human transcriptome. There are several examples of mammalian viruses regulating viral splicing or inhibiting cellular splicing in order to facilitate viral replication. Here, we describe a viral protein that induces alternative splicing of a...

  18. Alternative Pathway Inhibition by Exogenous Factor H Fails to Attenuate Inflammation and Vascular Leakage in Experimental Pneumococcal Sepsis in Mice.

    Science.gov (United States)

    van der Maten, Erika; van Selm, Saskia; Langereis, Jeroen D; Bootsma, Hester J; van Opzeeland, Fred J H; de Groot, Ronald; de Jonge, Marien I; van der Flier, Michiel

    2016-01-01

    Streptococcus pneumoniae is a common cause of sepsis. Effective complement activation is an important component of host defence against invading pathogens, whilst excessive complement activation has been associated with endothelial dysfunction and organ damage. The alternative pathway amplification loop is important for the enhancement of complement activation. Factor H is a key negative regulator of the alternative pathway amplification loop and contributes to tight control of complement activation. We assessed the effect of inhibition of the alternative pathway on sepsis associated inflammation and disease severity using human factor H treatment in a clinically relevant mice model of pneumococcal sepsis. Mice were infected intravenously with live Streptococcus pneumoniae. At the first clinical signs of infection, 17 hours post-infection, mice were treated with ceftriaxone antibiotic. At the same time purified human factor H or in controls PBS was administered. Treatment with human factor H did not attenuate disease scores, serum pro-inflammatory cytokines, or vascular permeability and did not significantly affect C3 and C3a production at 26 h post-infection. Therefore, we conclude that inhibition of the alternative complement pathway by exogenous human factor H fails to attenuate inflammation and vascular leakage at a clinically relevant intervention time point in pneumococcal sepsis in mice. PMID:26872035

  19. Electromagnetic Decay of the $\\Sigma^{0}(1385)$ to $\\Lambda\\gamma$

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Dustin; Adhikari, Krishna; Adikaram-Mudiyanselage, Dasuni; Aghasyan, Mher; Amaryan, Moscov; Baghdasaryan, Hovhannes; Ball, J P; Ball, Jacques; Battaglieri, Marco; Batourine, V; Bedlinskiy, Ivan; Bennett, Robert; Biselli, Angela; Branford, Derek; Briscoe, Wilbert; Brooks, William; Burkert, Volker; Careccia, Sharon; Carman, Daniel; Casey, Liam; Cole, Philip; Contalbrigo, Marco; Crede, Volker; D& #x27; Angelo, Annalisa; Daniel, AJI; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Deur, Alexandre; Dey, Biplap; Dickson, Richard; Djalali, Chaden; Doughty, David; Dupre, Raphael; Egiyan, Hovanes; El Alaoui, Ahmed; Elfassi, Lamiaa; Eugenio, Paul; Fedotov, Gleb; Fegan, Stuart; Forest, Tony; Gabrielyan, Marianna; Gavalian, Gagik; Gevorgyan, Nerses; Giovanetti, Kevin; Girod, Francois-Xavier; Gohn, Wesley; Golovach, Evgeny; Gothe, Ralf; Graham, Lewis; Guidal, Michel; Guegan, Baptiste; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Holtrop, Maurik; Ilieva, Yordanka; Ireland, David; Isupov, Evgeny; Jawalkar, Sucheta; Jenkins, David; Jo, Hyon-Suk; Joo, Kyungseon; Khandaker, Mahbubul; Khetarpal, Puneet; Kim, Andrey; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Konczykowski, Piotr; Kubarovsky, Valery; Kuleshov, Sergey; Kuznetsov, Viacheslav; Lu, Haiyun; MacGregor, Ian; Markov, Nikolai; McAndrew, Josephine; KcKinnon, Bryan; Meyer, Curtis; Micherdzinska, Anna; Mirazita, Marco; Mokeev, Viktor; Moreno, Brahim; Moriya, Kei; Morrison, Brian; Moutarde, Herve; Munevar Espitia, Edwin; Nadel-Turonski, Pawel; Ni, Andrey; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Osipenko, Mikhail; Ostrovidov, Alexander; Paremuzyan, Rafayel; Park, Kijun; Park, Sungkyun; Pasyuk, Eugene; Pasyuk, Evgueni; Pereira, Sergio; Pappalardo, Luciano; Pisano, Silvia; Pogorelko, Oleg; Pozdnyakov, Sergey; Price, John; Procureur, Sebastien; Protopopescu, Dan; Raue, Brian; Ripani, Marco; Ritchie, Barry; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Saini, Mukesh; Salgado, Carlos; Schott, Diane; Schumacher, Reinhard; Seder, Erin; Seraydaryan, Heghine; Sharabian, Youri; Smith, Elton; Smith, Gregory; Sober, Daniel; Stepanyan, Stepan; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tang, Wei; Taylor, Charles; Vernarsky, Brian; Vineyard, Michael; Voutier, Eric; Weinstein, Lawrence; Watts, Daniel; Wood, Michael; Zachariou, Nicholas; Zana, Lorenzo; Zhao, Bo

    2011-04-01

    The electromagnetic decay $\\Sigma^0(1385) \\to \\Lambda \\gamma$ was studied using the CLAS detector at the Thomas Jefferson National Accelerator Facility. A real photon beam with a maximum energy of 3.8 GeV was incident on a proton target, producing an exclusive final state of $K^+\\Sigma^{*0}$. We report the decay widths ratio $\\Sigma^0(1385) \\to \\Lambda\\gamma$/ $\\Sigma^0(1385) \\to \\Lambda\\pi^0$ = $1.42 \\pm 0.12(\\text{stat})_{-0.07}^{+0.11}(\\text{sys})$%. This ratio is larger than most theoretical predictions by factors ranging from 1.5-3, but is consistent with the only other experimental measurement. From the reported ratio we calculate the partial width and electromagnetic transition magnetic moment for $\\Sigma^0(1385) \\to \\Lambda\\gamma$.

  20. The free $\\sigma$CFTs

    CERN Document Server

    Guerrieri, Andrea; Wen, Congkao

    2016-01-01

    We introduce the conformal field theories that describe the shadows of the lowest dimension composites made out of massless free scalars and fermions in $d$ dimensions. We argue that these theories can be consistently defined as free CFTs for even $d\\geq 4$. We use OPE techniques to study their spectrum and show that for $d\\rightarrow\\infty$ it matches that of free bosonic CFTs in $d=6$ and $d=4$ dimensions. For these $\\sigma$CFTs we calculate $c_T$ in $d=6,8,10$ and $12$ dimensions using the OPE and also a direct construction of their higher-derivative energy momentum tensors. Our results agree with the general proposal of arXiv:1601.07198.

  1. Geometry of Membrane Sigma Models

    CERN Document Server

    Vysoky, Jan

    2015-01-01

    String theory still remains one of the promising candidates for a unification of the theory of gravity and quantum field theory. One of its essential parts is relativistic description of moving multi-dimensional objects called membranes (or p-branes) in a curved spacetime. On the classical field theory level, they are described by an action functional extremalising the volume of a manifold swept by a propagating membrane. This and related field theories are collectively called membrane sigma models. Differential geometry is an important mathematical tool in the study of string theory. It turns out that string and membrane backgrounds can be conveniently described using objects defined on a direct sum of tangent and cotangent bundles of the spacetime manifold. Mathematical field studying such object is called generalized geometry. Its integral part is the theory of Leibniz algebroids, vector bundles with a Leibniz algebra bracket on its module of smooth sections. Special cases of Leibniz algebroids are better ...

  2. Exploring the Supersymmetric $\\sigma$ Model

    CERN Document Server

    De Oliveira-Imbiriba, B C

    1999-01-01

    The purpose of this work is to present some basic concepts about the non-linear sigma model in a simple and direct way. We start with showing the bosonic model and the Wess-Zumino-Witten term, making some comments about its topological nature, and its association with the torsion. It is also shown that to cancel the quantum conformal anomaly the model should obey the Einstein equations. We provide a quick introduction about supersymmetry in chapter 2 to help the understanding the supersymmetric extension of the model. In the last chapter we present the supersymmetric model and its equations of motion. Finally we work-out the two-supersymmetry case, introducing the chiral as well as the twisted chiral fields, expliciting the very specific $SU(2)\\otimes U(1)$ case.

  3. Resurrection of the $\\sigma$ meson

    CERN Document Server

    Törnqvist, N A; Tornqvist, Nils A; Roos, Matts

    1995-01-01

    It is shown from a very general model and an analysis of data on the lightest 0++ meson nonet that the f0(980) and f0(1200) resonance poles are two manifestations of the same ss state. Similarily the a0(980) and the a0(1450) are likely to be two manifestations of the same qq state. On the other hand, the uu+dd state, when unitarized and strongly distorted by hadronic mass shifts, becomes an extremely broad Breit-Wigner-like background, m=860 MeV, Gamma=880 MeV, with its pole at s=(0.158-i0.235) GeV^2. This we identify with the sigma meson required by models for spontaneous breaking of chiral symmetry.

  4. De praktijk van Lean Six Sigma

    NARCIS (Netherlands)

    R.J.M.M. Does; H. de Koning

    2008-01-01

    Zowel Lean als Six Sigma zijn benaderingen van kwaliteits- en efficiëntieverbetering die op dit moment sterk in de belangstelling staan van zowel de industrie als de dienstverlening. Lean Six Sigma integreert beide benaderingen. Ze wordt door sommigen gezien als panacee voor alle mogelijke organisat

  5. Lean Six Sigma in a hospital

    NARCIS (Netherlands)

    J. van den Heuvel; R.J.M.M. Does; H. de Koning

    2006-01-01

    Abstract Hospitals today face major challenges. Patients demand quality of care to be improved continuously. Health insurance companies demand the lowest possible prices. Lean Six Sigma is a program that can help healthcare providers to achieve these (seemingly) conflicting goals. Lean Six Sigma is

  6. Sigma meson in heavy ion collision

    International Nuclear Information System (INIS)

    We want to present a short theoretical prediction of the behaviour of the sigma meson in heavy ion collisions. It is considered that the sigma meson is a pion-pion correlation, resulting from the decay of the N*(1440) resonance. There will be presented some QMD simulations. (authors)

  7. Integrating the Many Facets of Six Sigma

    NARCIS (Netherlands)

    J. de Mast

    2007-01-01

    We seek to provide a unified characterization of Six Sigma by studying the phenomenon from the perspectives of business economics, organizational theory, competitive strategy and industrial statistics, and we pinpoint its core methodological principles. We describe Six Sigma as a prescriptive framew

  8. Perturbation theory for string sigma models

    CERN Document Server

    Bianchi, Lorenzo

    2016-01-01

    In this thesis we investigate quantum aspects of the Green-Schwarz superstring in various AdS backgrounds relevant for the AdS/CFT correspondence, providing several examples of perturbative computations in the corresponding integrable sigma-models. We start by reviewing in details the supercoset construction of the superstring action in $AdS_5 \\times S^5$, pointing out the limits of this procedure for $AdS_4$ and $AdS_3$ backgrounds. For the $AdS_4 \\times CP^3$ case we give a thorough derivation of an alternative action, based on the double-dimensional reduction of eleven-dimensional super-membranes. We then consider the expansion about the BMN vacuum and the S-matrix for the scattering of worldsheet excitations in the decompactification limit. To evaluate its elements efficiently we describe a unitarity-based method resulting in a very compact formula yielding the cut-constructible part of any one-loop two-dimensional S-matrix. In the second part of this review we analyze the superstring action on $AdS_4 \\ti...

  9. THE LEAN AND SIX SIGMA SINERGY

    Directory of Open Access Journals (Sweden)

    Mirko Sokovic

    2008-12-01

    Full Text Available Many organizations, dealing with continuous improvement methods, have realized that Lean and Six Sigma methodologies complement each other. Lean manufacturing focuses on the remova l of waste so that all processes in the total system add value from the customers' perspectives. The main emphasis of Six Sigma is the application of statistical tools in a disciplined manner, which requires data-driven decision-making. The integration of Lean and Six Sigma provides a synergetic effect, a rapid process improvement strategy for attaining organizational goals. When separated, Lean manufacturing cannot bring a process under statistical control, and Six Sigma cannot dramatically improve cycle time or reduce invested capital. Together, synergistic qualities are created to maximize the potential for a process improvement. The paper deals with Lean and Six Sigma principles and approaches used in modern manufacturing for process improvements, and bring forward benefits that are gained when these two methodologies are integrated.

  10. Schools as Sanctuaries: A Systematic Review of Contextual Factors Which Contribute to Student Retention in Alternative Education

    Science.gov (United States)

    O'Gorman, Eva; Salmon, Nancy; Murphy, Carol-Anne

    2016-01-01

    Early school leaving is an international concern. Previous research indicates that the school context contributes to early school leaving. This systematic review is aimed to gather marginalised young peoples' perceptions concerning contextual factors that contributed to and interfered with their decisions to stay in alternative education.…

  11. The transcription factor PU.1 promotes alternative macrophage polarization and asthmatic airway inflammation.

    Science.gov (United States)

    Qian, Feng; Deng, Jing; Lee, Yong Gyu; Zhu, Jimmy; Karpurapu, Manjula; Chung, Sangwoon; Zheng, Jun-Nian; Xiao, Lei; Park, Gye Young; Christman, John W

    2015-12-01

    The transcription factor PU.1 is involved in regulation of macrophage differentiation and maturation. However, the role of PU.1 in alternatively activated macrophage (AAM) and asthmatic inflammation has yet been investigated. Here we report that PU.1 serves as a critical regulator of AAM polarization and promotes the pathological progress of asthmatic airway inflammation. In response to the challenge of DRA (dust mite, ragweed, and Aspergillus) allergens, conditional PU.1-deficient (PU/ER(T)(+/-)) mice displayed attenuated allergic airway inflammation, including decreased alveolar eosinophil infiltration and reduced production of IgE, which were associated with decreased mucous glands and goblet cell hyperplasia. The reduced asthmatic inflammation in PU/ER(T)(+/-) mice was restored by adoptive transfer of IL-4-induced wild-type (WT) macrophages. Moreover, after treating PU/ER(T)(+/-) mice with tamoxifen to rescue PU.1 function, the allergic asthmatic inflammation was significantly restored. In vitro studies demonstrate that treatment of PU.1-deficient macrophages with IL-4 attenuated the expression of chitinase 3-like 3 (Ym-1) and resistin-like molecule alpha 1 (Fizz-1), two specific markers of AAM polarization. In addition, PU.1 expression in macrophages was inducible in response to IL-4 challenge, which was associated with phosphorylation of signal transducer and activator of transcription 6 (STAT6). Furthermore, DRA challenge in sensitized mice almost abrogated gene expression of Ym-1 and Fizz-1 in lung tissues of PU/ER(T)(+/-) mice compared with WT mice. These data, all together, indicate that PU.1 plays a critical role in AAM polarization and asthmatic inflammation.

  12. Power efficient Delta Sigma bitstream encoder/decoder

    OpenAIRE

    2009-01-01

    The thesis presents design and implementation of components for recoding of signals between binary PCM and a bitstream representation. The bitstream representation enables real time signal processing using a power efficient algorithm for time-domain cross-correlation. The greatest savings are made when the system is restricted to a low oversampling ratio (OSR). A fully digital Delta Sigma encoder is presented. The low OSR is the largest limiting factor in the system. Both simulations and ...

  13. Exploring the Six Sigma phenomenon using multiple case study evidence

    OpenAIRE

    Nonthaleerak, P; Hendry, L

    2008-01-01

    Purpose – This research paper aims to: explore areas of weakness in six sigma implementations that may require enhancements in the methodology; to investigate implementation differences between manufacturing and services; and to investigate critical success factors. Design/methodology/approach – Exploratory empirical evidence is presented from nine case study companies in Thailand, including manufacturers, sales and service companies and a national airline. Findings – Key findings include: si...

  14. Exploiting Six Sigma by using DTS

    Directory of Open Access Journals (Sweden)

    Anuradha

    2011-05-01

    Full Text Available Six Sigma has been very successfully applied in manufacturing. Is it also applicable to software, and ICT? Six Sigma is about cost reduction by eliminating defects. Six Sigma uses the following three principles: Focus on customers, Process orientation, Leadership based on metrics The big question as to whether Six Sigma can really be applied as successfully in the software industry as it was to manufacturing is still being debated. The real challenge is to see if it can be implemented without reinventing the wheel. There is also disagreement among leaders in the software industry about the need for Six Sigma. Applying Six Sigma to software development makes software projects transparent to both management and customers. Transparency requires an important cultural change. As a result, after transparency is achieved, completing accurate project estimations while meeting both deadlines and customer requirements becomes a lot easier. I had implemented DTS as a prototype by using techniques of six sigma to track an error. With the help of graph I also show the no. of bug incremented or decremented versus date of track.

  15. Tree-level amplitudes in the nonlinear sigma model

    Science.gov (United States)

    Kampf, Karol; Novotný, Jirí; Trnka, Jaroslav

    2013-05-01

    We study in detail the general structure and further properties of the tree-level amplitudes in the SU( N) nonlinear sigma model. We construct the flavor-ordered Feynman rules for various parameterizations of the SU( N) fields U ( x), write down the Berends-Giele relations for the semi-on-shell currents and discuss their efficiency for the amplitude calculation in comparison with those of renormalizable theories. We also present an explicit form of the partial amplitudes up to ten external particles. It is well known that the standard BCFW recursive relations cannot be used for reconstruction of the the on-shell amplitudes of effective theories like the SU( N) nonlinear sigma model because of the inappropriate behavior of the deformed on-shell amplitudes at infinity. We discuss possible generalization of the BCFW approach introducing "BCFW formula with subtractions" and with help of Berends-Giele relations we prove particular scaling properties of the semi-on-shell amplitudes of the SU( N) nonlinear sigma model under specific shifts of the external momenta. These results allow us to define alternative deformation of the semi-on-shell amplitudes and derive BCFW-like recursion relations. These provide a systematic and effective tool for calculation of Goldstone bosons scattering amplitudes and it also shows the possible applicability of on-shell methods to effective field theories. We also use these BCFW-like relations for the investigation of the Adler zeroes and double soft limit of the semi-on-shell amplitudes.

  16. Optimal Six-Sigma Level in TFT-LCD Manufacturing: A Case Study

    Directory of Open Access Journals (Sweden)

    Jen-Ming Chenand Tsung-Te Cheng

    2010-11-01

    Full Text Available Abstract. This paper deals with six-sigma project decision-making in TFT-LCDmanufacturing using multi-objective goal programming approach to assist theproject leader in deciding process improving opportunities. The model considers amulti-stage process rolled throughput yield in a TFT Liquid Crystal Display (LCDmajor Array, Cell, and Module process. Meanwhile, the other factors such asinvestment cost, profit, and expected sigma level will be taken into consideration inthe model. Numerical result shows an organization can reap the profit through thesix-sigma project implementation.

  17. Human factors in design modifications: panel alternative stop in Almaraz; Factores humanos en modificaciones de diseno: panel deparada alternativa en CN Almaraz

    Energy Technology Data Exchange (ETDEWEB)

    Roman, Y.; Bote, J.

    2015-07-01

    Human Factors Engineering has acquired a crucial role in the development of any design modification (DM), where every aspect relative to any interaction with the human user has to be taken into account at any stage thereof. Considering this, during the last years, Almaraz Nuclear Powe Plants has developed a program of Human Factors Engineering in order to reach the internationally recognized standards or systematic collected on NUREG 0711 Human Factors Engineering Program Review Model (NRC). One of the most important projects of this program at Almaraz Nuclear Power Plant has been the implementation of the Alternative Stop Panel and their corresponding Transfer Panels. (Author)

  18. SIGMA WEB INTERFACE FOR REACTOR DATA APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Pritychenko,B.; Sonzogni, A.A.

    2010-05-09

    We present Sigma Web interface which provides user-friendly access for online analysis and plotting of the evaluated and experimental nuclear reaction data stored in the ENDF-6 and EXFOR formats. The interface includes advanced browsing and search capabilities, interactive plots of cross sections, angular distributions and spectra, nubars, comparisons between evaluated and experimental data, computations for cross section data sets, pre-calculated integral quantities, neutron cross section uncertainties plots and visualization of covariance matrices. Sigma is publicly available at the National Nuclear Data Center website at http://www.nndc.bnl.gov/sigma.

  19. Alternative energy as a factor of ecological and energy security: features of Russia

    Directory of Open Access Journals (Sweden)

    Boris Nikolaevich Porfiryev

    2011-06-01

    Full Text Available This paper analyzes the current situation in the sphere of alternative energy engineering in Russia. On the one hand, the national economy and the population in general do not have problems with energy supply and Russia in general is the world's largest exporter of energy. On the other hand, centralized energy supply covers only one third of its territory and two-thirds are in the area of decentralized and autonomous power supply. In the current situation, energy sources that are independent of centralized networks based on clean technologies are a promising alternative. The paper assesses the current state of alternative energy development in the world and in Russia, its potential and prospects. It was found out that development and qualitative improvement of the regulatory framework should have priority for alternative energy mastering in Russia as well as active joint action of government, business and civic leaders to gradually consolidate in public consciousness and behaviour of a new culture of energy consumption based on the rules of economy and environmental safety. The analysis of the proposals for the development of alternative energy industries in Russia was made. Particular attention is paid to energy saving experience and energy efficiency in housing services and public utilities. Questions on the creation and development of formal and informal institutions of non-conventional energy sources usage are asked.

  20. Interaction of sigma 70 with Escherichia coli RNA polymerase core enzyme studied by surface plasmon resonance.

    Science.gov (United States)

    Ferguson, A L; Hughes, A D; Tufail, U; Baumann, C G; Scott, D J; Hoggett, J G

    2000-09-22

    The interaction between the core form of bacterial RNA polymerases and sigma factors is essential for specific promoter recognition, and for coordinating the expression of different sets of genes in response to varying cellular needs. The interaction between Escherichia coli core RNA polymerase and sigma 70 has been investigated by surface plasmon resonance. The His-tagged form of sigma 70 factor was immobilised on a Ni2+-NTA chip for monitoring its interaction with core polymerase. The binding constant for the interaction was found to be 1.9x10(-7) M, and the dissociation rate constant for release of sigma from core, in the absence of DNA or transcription, was 4x10(-3) s(-1), corresponding to a half-life of about 200 s. PMID:11007979

  1. Enhanced understanding of energy ratepayers: Factors influencing perceptions of government energy efficiency subsidies and utility alternative energy use

    International Nuclear Information System (INIS)

    This study explores factors related to energy consumers' perceptions of government subsidies for utility provided energy efficiency (EE) programs and for utility providers' use of more clean/alternative energy sources. Demographic factors, attitudes, planned purchases, and perceptions of utility provider motives in relation to governmental and utility provider EE initiatives (i.e. providing discounts and coupons for CFL bulbs), plus the influence of gain- and loss-framed messages are investigated. Over 2000 respondents completed a 16 item phone survey. Hierarchical regression explained 38% of the variance in reactions regarding government subsidies of the cost of utility provided EE programs and 43% of the variance in perceptions involving whether utility companies should use of more clean or alternative forms of energy. Gender and party differences emerged. Loss-framed messages were more important when the issue was government subsidies. Both gain- and loss-framed messages were important when clean/alternative energy was the issue. - Highlights: • Over 2000 ratepayers were surveyed on their attitudes, planned behaviors and perceptions towards energy efficiency programs. • Almost 40% of how ratepayers feel about government subsidies and utility use of clean/alternative energy was explained. • Loss-framed messages were more effective when the dependent variable was ratepayer perception of government subsidies

  2. Lean six sigma application to transportation logistics

    Directory of Open Access Journals (Sweden)

    Simone Tavares Fernandes

    2012-06-01

    Full Text Available This work presents the application of Lean Six Sigma in a case study of a metallurgic industry. The Six Sigma and the Lean are two processes used by enterprises in Brazil and worldwide. Currently the integration of these processes is a challenge for these companies, which search a way more efficient to reduce their wastes and to adapt to the needs of their markets. The paper had as purpose to demonstrate the applicability of the Lean Six Sigma in a real logistical problem related to the transportation of goods among units of a metallurgic industry. The stages used for the solution of the problem follow the DMAIC cycle – Define, Measure, Analyze, Improve and Control. The paper presents in details the integrated approach of the improvement processes Lean and Six Sigma, their tools set, as well the excellent results obtained in the case study.

  3. Measurement of Natural Widths of Sigma-c-0 and Sigma-c-++ Baryons

    CERN Document Server

    Link, J M; Reyes, M; Yager, P M; Anjos, J C; Bediaga, I; Göbel, C; Magnin, J; Massafferri, A; De Miranda, J M; Pepe, I M; Dos Reis, A C; Carrillo, S; Casimiro, E; Cuautle, E; Sánchez-Hernández, A; Uribe, C; Vázquez, F; Agostino, L; Cinquini, L; Cumalat, J P; O'Reilly, B; Ramírez, J E; Segoni, I; Butler, J N; Cheung, H W K; Chiodini, G; Gaines, I; Garbincius, P H; Garren, L A; Gottschalk, E; Kasper, P H; Kreymer, A E; Kutschke, R; Bianco, S; Fabbri, Franco Luigi; Zallo, A; Cawlfield, C; Kim, D Y; Rahimi, A; Wiss, J; Gardner, R; Kryemadhi, A; Chung, Y S; Kang, J S; Ko, B R; Kwak, J W; Lee, K B; Park, H; Alimonti, G; Barberis, S; Boschini, M; D'Angelo, P; Di Corato, M; Dini, P; Edera, L; Erba, S; Giammarchi, M; Inzani, P; Leveraro, F; Malvezzi, S; Menasce, D; Mezzadri, M; Milazzo, L; Moroni, L; Pedrini, D; Pontoglio, C; Prelz, F; Rovere, M; Sala, S; Davenport, T F; Arena, V; Boca, G; Bonomi, G; Gianini, G; Liguori, G; Merlo, M M; Pantea, D; Ratti, S P; Riccardi, C; Vitulo, P; Hernández, H; López, A M; Méndez, H; Méndez, L; Montiel, E; Olaya, D; Paris, A; Quinones, J; Rivera, C; Xiong, W; Zhang, Y; Wilson, J R; Cho, K; Handler, T; Mitchell, R; Engh, D; Hosack, M; Johns, W E; Nehring, M; Sheldon, P D; Stenson, K; Vaandering, E W; Webster, M; Sheaff, M

    2002-01-01

    In this paper we present a measurement of the natural widths of $\\Sigma_c^0$ and $\\Sigma_c^{++}$. Using data from the FOCUS experiment, we find $\\Gamma(\\Sigma_c^0) = 1.55 +0.41/-0.37 \\pm 0.38$ MeV/c^2 and $\\Gamma(\\Sigma_c^0) = 2.05 +0.41/-0.38 \\pm 0.38$ MeV/c^2. The first errors are statistical, the second systematic. These results are obtained with a sample of 913 $\\Sigma_c^0 \\to \\Lambda_c^+ \\pi^-$ decays and 1110 $\\Sigma_c^++ \\to \\Lambda_c^+ \\pi^+$ decays. These results are compared with recent theoretical predictions. PACS numbers: 14.20.Lq 13.30Eg

  4. Measurements of the $\\Sigma_{c}^{0}$ and $\\Sigma_{c}^{++}$ Mass Splittings

    CERN Document Server

    Link, J M; Reyes, M; Yager, P M; Anjos, J C; Bediaga, I; Göbel, C; Magnin, J; De Miranda, J M; Pepe, I M; Dos Reis, A C; Simão, F R A; Carrillo, S; Casimiro, E; Méndez, H; Sánchez-Hernández, A; Uribe, C; Vázquez, F; Cinquini, L; Cumalat, J P; Ramírez, J E; O'Reilly, B; Vaandering, E W; Butler, J N; Cheung, H W K; Gaines, I; Garbincius, P H; Garren, L A; Gottschalk, E E; Gourlay, S A; Kasper, P H; Kreymer, A E; Kutschke, R; Bianco, S; Fabbri, Franco Luigi; Sarwar, S; Zallo, A; Cawlfield, C; Kim, D Y; Park, K S; Rahimi, A; Wiss, J; Gardner, R; Chung, Y S; Kang, J S; Ko, B R; Kwak, J W; Lee, K B; Myung, S S; Park, H; Alimonti, G; Boschini, M; Brambilla, D; Caccianiga, B; Calandrino, A; D'Angelo, P; Di Corato, M; Dini, P; Giammarchi, M G; Inzani, P; Leveraro, F; Malvezzi, S; Menasce, D; Mezzadri, M; Milazzo, L; Moroni, L; Pedrini, D; Prelz, F; Rovere, M; Sala, A; Sala, S; Davenport, T F; Arena, V; Boca, G; Bonomi, G; Gianini, G; Liguori, G; Merlo, M; Pantea, D; Ratti, S P; Riccardi, C; Torre, P; Viola, L; Vitulo, P; Hernández, H; López, A M; Méndez, L; Mirles, M A; Montiel, E; Olaya, D; Quinones, J; Rivera, C; Zhang, Y; Copty, N K; Purohit, M; Wilson, J R; Cho, K; Handler, T; Engh, D; Johns, W E; Hosack, M; Nehring, M S; Sales, M; Sheldon, P D; Stenson, K; Webster, M S; Sheaff, M; Kwon, Y J

    2000-01-01

    Using a high statistics sample of photoproduced charmed particles from the FOCUS experiment at Fermilab (FNAL-E831), we measure the mass splittings of the charmed baryons Sigma_c^0 and Sigma_c^{++}. We find M(Sigma_c^0 - Lambda_c^+) = 167.38 +/- 0.21 +/- 0.13 MeV/c^2 and M(Sigma_c^++ - Lambda_c^+) = 167.35 +/- 0.19 +/- 0.12 MeV/c^2 with samples of 362 +/- 36 and 461 +/- 39 events, respectively. We measure the isospin mass splitting M(Sigma_c^++ - Sigma_c^0) to be -0.03 +/- 0.28 +/- 0.11 Mev/c^2. The first errors are statistical and the second are systematic.

  5. Bacillus subtilis Pro-sigmaE fusion protein localizes to the forespore septum and fails to be processed when synthesized in the forespore.

    OpenAIRE

    Ju, J; Luo, T.; Haldenwang, W G

    1997-01-01

    Endospore formation in Bacillus subtilis begins with an asymmetric cell division that partitions the bacterium into mother cell and forespore compartments. Mother cell-specific gene expression is initiated by sigmaE, a transcription factor that is active only in the mother cell but which existed as an inactive precursor (pro-sigmaE) in the predivisional cell. Activation of pro-sigmaE involves the removal of 27 amino acids from its amino terminus. A chimera of pro-sigmaE and the green fluoresc...

  6. The conserved splicing factor SUA controls alternative splicing of the developmental regulator ABI3 in Arabidopsis.

    NARCIS (Netherlands)

    Sugliani, M.; Brambilla, V.; Clerkx, E.J.M.; Koornneef, M.; Soppe, W.J.J.

    2010-01-01

    ABSCISIC ACID INSENSITIVE3 (ABI3) is a major regulator of seed maturation in Arabidopsis thaliana. We detected two ABI3 transcripts, ABI3- and ABI3-ß, which encode full-length and truncated proteins, respectively. Alternative splicing of ABI3 is developmentally regulated, and the ABI3-ß transcript a

  7. Predicting Language Outcomes for Children Learning Augmentative and Alternative Communication: Child and Environmental Factors

    Science.gov (United States)

    Brady, Nancy C.; Thiemann-Bourque, Kathy; Fleming, Kandace; Matthews, Kris

    2013-01-01

    Purpose: To investigate a model of language development for nonverbal preschool-age children learning to communicate with augmentative or alternative communication. Method: Ninety-three preschool children with intellectual disabilities were assessed at Time 1, and 82 of these children were assessed 1 year later, at Time 2. The outcome variable was…

  8. DEPLOYMENT OF SIX SIGMA METHODOLOGY IN PHACOEMULSIFICATION CATARACT SURGERY

    Directory of Open Access Journals (Sweden)

    Ibrahim SAHBAZ

    2014-04-01

    Full Text Available The purpose of this study is to show how a public eye care center in Turkey initiated Six Sigma principles to reduce the number of complications encountered during and after phacoemulsification cataract surgeries. To analyze the 3-year data, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC improvement cycle such as SIPOC table, Fishbone Diagram and, Failure, Mode and Effect Analysis were implemented. Experience of the ophthalmic surgeon, patient’s anatomy, cooperation of patient during the surgery, sterilization and hygiene, attention of assistant surgeon, calibration of equipment and quality/chemical composition of intraocular material were identified to be Critical-to-Quality (CTQ factors for a successful phacoemulsification cataract surgery. The most frequently occurring complication was found to be iris atrophy. The process sigma level for the process was found to be 3.958.

  9. DEVELOPMENT OF SIX SIGMA INFRASTRUCTURE FOR STRABISMUS SURGERIES

    Directory of Open Access Journals (Sweden)

    Mehmet Tolga Taner

    2014-01-01

    Full Text Available The purpose of this study is to show how a private eye care center in Turkey developed a Six Sigma infrastructure to investigate the root causes of complications occuring during strabismus surgeries. To analyze the collected data, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC improvement cycle such as SIPOC table, Fishbone Diagram and, Failure, Mode and Effect Analysis were implemented. Patient’s eye anatomy, experience of the anesthesiologist, experience/attention of the strabismus surgeon was identified to be Critical-to-Quality (CTQ factors for a successful strabismus surgery. The most frequent complications of strabismus surgeries were found to be X, Y and Z. The process sigma level was found to be 3.2025.

  10. Finishing post-primary education: a systematic review of contextual factors which contribute to student retention in alternative education.

    OpenAIRE

    O'Gorman, Eva

    2014-01-01

    peer-reviewed Background: The EU set a target of reducing early school leaving to no more than 10% by the year 2020. Previous research indicates that the school context contributes to early school leaving. This systematic review aims to identify factors within the physical, social, cultural and virtual contexts which may contribute to student retention in alternative educational settings. This study contributes an important synthesis of existing evidence for policy makers, educators and ot...

  11. Effective Lagrangian for the linear sigma model at m/sub sigma/ → infinity

    International Nuclear Information System (INIS)

    A new functional integration method is developed for integrating out the heavy chiral scalar field in the linear sigma model to render a finite chiral invariant effective Lagrangian in the one-loop approximation after proper renormalization at m/sub sigma/ → infinity. In addition to the minimal nonlinear sigma model term, the effective Lagrangian also contains a finite chiral invariant quantum correction term with four derivatives

  12. An alternative strategy to generate coding sequence of macrophage migration inhibitory factor-2 of Wuchereria bancrofti

    OpenAIRE

    Nikhil Chauhan; Hoti, S.L.

    2016-01-01

    Background & objectives: Different developmental stages of Wuchereria bancrofti, the major causal organism of lymphatic filariasis (LF), are difficult to obtain. Beside this limitation, to obtain complete coding sequence (CDS) of a gene one has to isolate mRNA and perform subsequent cDNA synthesis which is laborious and not successful at times. In this study, an alternative strategy employing polymerase chain reaction (PCR) was optimized and validated, to generate CDS of Macrophage migration ...

  13. Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

    OpenAIRE

    Clynes, David; Jelinska, Clare; Xella, Barbara; Ayyub, Helena; Scott, Caroline; Mitson, Matthew; Taylor, Stephen; Higgs, Douglas R.; Gibbons, Richard J.

    2015-01-01

    Fifteen per cent of cancers maintain telomere length independently of telomerase by the homologous recombination (HR)-associated alternative lengthening of telomeres (ALT) pathway. A unifying feature of these tumours are mutations in ATRX. Here we show that expression of ectopic ATRX triggers a suppression of the pathway and telomere shortening. Importantly ATRX-mediated ALT suppression is dependent on the histone chaperone DAXX. Re-expression of ATRX is associated with a reduction in replica...

  14. Six sigma quality for fuel manufacturing

    International Nuclear Information System (INIS)

    It is widely recognized that operational performance in product manufacturing is largely determined by understanding and maintaining process capability. By definition, Six Sigma is a statistical unit of measure reflecting process capability that yields less' than 6.8 defects per million product produced. Statistically, this translates into obtaining a long term manufacturing process capability of ± 4.5 standard deviations about the mean within specification limits. The heart of the Six Sigma program developed by the Six Sigma Academy is what we refer to as the Breakthrough Strategy. This rigorous analytical methodology is the driving force in obtaining world class performance of Six Sigma. The methodology applies statistical and practical tools in resolving a problem or improving a product or process. The application of Six Sigma focuses on attacking process input variables (independent) rather than the output variables. Focusing on these independent variables (temperature, power, force, etc.) and the variation in the end product they create, enables us to get to the root of the problem rather than react to the symptoms of the problem. In this manner we prevent defects from occurring rather than inspecting and monitoring the product. Why the need for such an ambitious program? It is estimated that the cost of failure (rework, scrap, warranties, etc.) can be as high as 15% of sales for companies typically operating at 3-4 sigma. In achieving Six Sigma, costs of failure are typically less than 5%. The thought of reducing business costs while achieving the recognition of being our customer's premier choice provides enormous incentive to reach such status. (author)

  15. THE RELATION AMONG SIX SIGMA AND OTHER MANAGERIAL TECHNIQUES OF IMPROVING THE PERFORMANCES OF THE ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    AMALIA VENERA TODORUŢ

    2009-01-01

    Full Text Available In this work we proposed myself to approach aspects bound to theimportance of Six Sigma method in what concerns the growth of the organization’sperformances within a dynamic and hostile environment marked by the nowadays slump and bythe more and more sophisticated requests of the customers. Within my work I have gone overand presented the necessity of improving the processes through the Six Sigma method and Ihave analysed the external and internal factors “relatively fluid” and “relatively rigid” whichinfluence the attainment of some superior levels of processes’ performance. I have studied theSix Sigma model of improving the processes and I have emphasized the operational andmanagerial influences of this model. I have also analyzed the relation of complementarityamong the management system ISO 9000:2000, the Kaizen techniques, Total QualityManagement and Total Productive Maintenance and the strategy Six Sigma which has as resultthe growth of the economic performances.

  16. Alternative practices in curriculum design. Participation as a key factor and speaking out as right

    OpenAIRE

    Susana Barco

    2012-01-01

    During the 1990s, in the context of neo-liberal policies, curricular changes ocurred in Latin América which gave a leading role to technicians and experts in education, in the process of writing the curricular documents. Beyond the critiques these policies can receive, it is necessary to find alternative ways of elaborating curricular documents, based on democratic idea of teacher's real participation.In an action-research within the scope of a university and two experiences referred to in th...

  17. CAPM tests and alternative factor portfolio composition: getting the alphas right

    OpenAIRE

    De Moor, Lieven; Sercu, Piet

    2005-01-01

    We show that the results of a CAPM test are quite sensitive to the details of the test design. Especially crucial are the aspects related to the weight one gives to small, low-reputation stocks when constructing both the factor portfolios and the test or style portfolios whose returns are to be explained. To fit our observed returns we need to redesign the size and distress factor portfolios into two factor portfolios each, one for extremely small or distressed stocks relative to non-extreme ...

  18. On loop contributions in the linear sigma model

    Energy Technology Data Exchange (ETDEWEB)

    Toernqvist, Nils A

    1999-03-01

    Quantum loops ares studied in the linear sigma model with scalar and pseudoscalar multiplets and a planar interaction term {lambda}Tr[{sigma}{sigma}{sup +}{sigma}{sigma}{sup +}]. It is shown how quantum loops break the OZI rule and the tree-level octet-singlet degeneracy, and how the Goldstone theorem can be maintained also in an iterative scheme including some multiloop diagrams.

  19. DISCONTINUANCE OF SIX SIGMA PROGRAMS: A COMPARATIVE STUDY OF CASES DISCONTINUIDAD DE PROGRAMAS SEIS SIGMA: UN ESTUDIO COMPARATIVO DE CASOS DESCONTINUIDADE DE PROGRAMAS SEIS SIGMA: UM ESTUDO COMPARATIVO DE CASOS

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Mora Júnior

    2013-01-01

    Full Text Available This article presents a study of factors that influence discontinuance of Six Sigma quality programs and how the programs operate in an organizational context. This research  is based on a multi-case study conducted in a company of the electronics manufacturing sector and another in the service sector of call centers. Intra-case and inter-case analyses were performed on data from interviews. Eleven factors were identified that, in varying degrees influenced discontinuance of the Six Sigma program. Among these, four were more relevant: 1 lack of alignment of the Six Sigma program with the company's strategic objectives, 2 results and quality of projects and program did not meet expectations of senior management, 3 weak involvement of leaders with the program and, 4 inappropriate timing for the company's adoption of Six Sigma. Conclusions of the  research were that results of Six Sigma projects are more influenced by management and leadership (soft factors than by technical, methodological or infrastructural factors (hard factors. This article also proposes a conceptual model that seeks to explain how these factoEste artículo presenta un estudio sobre los factores que influencian la discontinuidad de programas de calidad Seis Sigma y como estos actúan en el contexto organizativo. Esta investigación está basada en un estudio multicaso realizado en una empresa del sector de manufactura de electrónicos y en otra del sector de servicios de  call center. Fueron realizados análisis  intracaso e  intercaso a partir de los datos provenientes de entrevistas y, como resultado, fueron identificados once factores que interfieren en diferentes grados en la discontinuidad del programa Seis Sigma. Entre ellos, cuatro tuvieron mayor relevancia: 1 falta de alineamiento del programa Seis Sigma con los objetivos estratégicos de la compañía; 2 resultados y calidad de los proyectos y del programa abajo de la expectativa de la alta

  20. An alternative factorization of the quantum harmonic oscillator and two-parameter family of self-adjoint operators

    Energy Technology Data Exchange (ETDEWEB)

    Arcos-Olalla, Rafael, E-mail: olalla@fisica.ugto.mx [Departamento de Física, DCI Campus León, Universidad de Guanajuato, Apdo. Postal E143, 37150 León, Gto. (Mexico); Reyes, Marco A., E-mail: marco@fisica.ugto.mx [Departamento de Física, DCI Campus León, Universidad de Guanajuato, Apdo. Postal E143, 37150 León, Gto. (Mexico); Rosu, Haret C., E-mail: hcr@ipicyt.edu.mx [IPICYT, Instituto Potosino de Investigacion Cientifica y Tecnologica, Apdo. Postal 3-74 Tangamanga, 78231 San Luis Potosí, S.L.P. (Mexico)

    2012-10-01

    We introduce an alternative factorization of the Hamiltonian of the quantum harmonic oscillator which leads to a two-parameter self-adjoint operator from which the standard harmonic oscillator, the one-parameter oscillators introduced by Mielnik, and the Hermite operator are obtained in certain limits of the parameters. In addition, a single Bernoulli-type parameter factorization, which is different from the one introduced by M.A. Reyes, H.C. Rosu, and M.R. Gutiérrez [Phys. Lett. A 375 (2011) 2145], is briefly discussed in the final part of this work. -- Highlights: ► Factorizations with operators which are not mutually adjoint are presented. ► New two-parameter and one-parameter self-adjoint oscillator operators are introduced. ► Their eigenfunctions are two- and one-parameter deformed Hermite functions.

  1. Six Lessons We Learned Applying Six Sigma

    Science.gov (United States)

    Carroll, Napoleon; Casleton, Christa H.

    2005-01-01

    As Chief Financial Officer of Kennedy Space Center (KSC), I'm not only responsible for financial planning and accounting but also for building strong partnerships with the CFO customers, who include Space Shuttle and International Space Station operations as well all who manage the KSC Spaceport. My never ending goal is to design, manage and continuously improve our core business processes so that they deliver world class products and services to the CFO's customers. I became interested in Six Sigma as Christa Casleton (KSC's first Six Sigma Black belt) applied Six Sigma tools and methods to our Plan and Account for Travel Costs Process. Her analysis was fresh, innovative and thorough but, even more impressive, was her approach to ensure ongoing, continuous process improvement. Encouraged by the results, I launched two more process improvement initiatives aimed at applying Six Sigma principles to CFO processes that not only touch most of my employees but also have direct customer impact. As many of you know, Six Sigma is a measurement scale that compares the output of a process with customer requirements. That's straight forward, but demands that you not only understand your processes but also know your products and the critical customer requirements. The objective is to isolate and eliminate the causes of process variation so that the customer sees consistently high quality.

  2. Measurements of sigma(e^+ e^- -> Upsilon(nS)pi^+pi^-) and sigma(e^+ e^- -> b bbar) in the Upsilon(10860) and Upsilon(11020) resonance regions

    CERN Document Server

    Santel, D; Chang, P; Abdesselam, A; Adachi, I; Aihara, H; Said, S Al; Arinstein, K; Asner, D M; Aushev, T; Ayad, R; Bakich, A M; Bansal, V; Bhuyan, B; Bobrov, A; Bondar, A; Bonvicini, G; Bračko, M; Browder, T E; Červenkov, D; Chekelian, V; Cheon, B G; Chilikin, K; Cho, K; Chobanova, V; Choi, S -K; Choi, Y; Cinabro, D; Dalseno, J; Danilov, M; Dingfelder, J; Doležal, Z; Drásal, Z; Drutskoy, A; Eidelman, S; Farhat, H; Fast, J E; Ferber, T; Gaur, V; Gabyshev, N; Garmash, A; Getzkow, D; Gillard, R; Goh, Y M; Haba, J; Hara, T; Hayasaka, K; Hayashii, H; He, X H; Hou, W -S; Hyun, H J; Iijima, T; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, Y; Jaegle, I; Joffe, D; Julius, T; Kang, K H; Kato, E; Kawasaki, T; Kiesling, C; Kim, D Y; Kim, H J; Kim, J B; Kim, J H; Kim, M J; Kim, S H; Kim, Y J; Ko, B R; Kodyš, P; Korpar, S; Križan, P; Krokovny, P; Kuzmin, A; Lange, J S; Lee, I S; Li, Y; Gioi, L Li; Libby, J; Liventsev, D; Lukin, P; Matvienko, D; Miyabayashi, K; Miyata, H; Mizuk, R; Mohanty, G B; Moll, A; Mori, T; Mussa, R; Nakano, E; Nakao, M; Nanut, T; Natkaniec, Z; Nisar, N K; Nishida, S; Ogawa, S; Okuno, S; Olsen, S L; Oswald, C; Pakhlov, P; Pakhlova, G; Park, C W; Park, H; Pedlar, T K; Petrič, M; Piilonen, L E; Ribežl, E; Ritter, M; Rostomyan, A; Ryu, S; Sakai, Y; Sandilya, S; Santelj, L; Sanuki, T; Savinov, V; Schneider, O; Schnell, G; Schwanda, C; Schwartz, A J; Senyo, K; Sevior, M E; Shebalin, V; Shibata, T -A; Shiu, J -G; Shwartz, B; Sibidanov, A; Simon, F; Sohn, Y -S; Solovieva, E; Starič, M; Steder, M; Tamponi, U; Tatishvili, G; Teramoto, Y; Trabelsi, K; Uchida, M; Uglov, T; Unno, Y; Uno, S; Van Hulse, C; Vanhoefer, P; Varner, G; Vinokurova, A; Wagner, M N; Wang, P; Wang, X L; Watanabe, M; Watanabe, Y; Won, E; Yamaoka, J; Yang, Y -P; Yashchenko, S; Yook, Y; Yusa, Y; Zhang, Z P; Zhilich, V; Zhulanov, V; Zupanc, A

    2016-01-01

    We report new measurements of $R_{\\Upsilon\\pi\\pi}\\equiv\\sigma(e^+e^-\\to \\Upsilon(n{\\rm S})\\pi^+\\pi^-)/\\sigma^0_{\\mu\\mu}$ ($n$ = 1, 2, 3) and $R_b\\equiv\\sigma(e^+e^-\\to b\\bar b)/\\sigma^0_{\\mu\\mu}$ (where $\\sigma^0_{\\mu\\mu}$ is the muon-pair Born cross section) in the region $\\sqrt{s} = 10.63$-$11.05$ GeV, based on data collected with the Belle detector. Distributions in $R_{\\Upsilon\\pi\\pi}$ and $R_b$ are fit for the masses and widths of the $\\Upsilon(10860)$ and $\\Upsilon(11020)$ resonances. Unlike $R_b$, which includes a large non-resonant $b\\bar{b}$ component, we find that $R_{\\Upsilon\\pi\\pi}$ is dominated by the two resonances. With $R_{\\Upsilon\\pi\\pi}$ as the basis, the total rate at the $\\Upsilon(10860)$ peak for known final states containing bottomonium(-like) resonances is estimated. We find that $\\Upsilon(10860)$ is essentially saturated by such modes, raising doubts about the validity of masses measured using $R_b$. With $R_{\\Upsilon\\pi\\pi}$, we measure $M_{10860}=(10891.1\\pm3.2^{+0.6}_{-1.5})$ MeV/$c...

  3. Black-box Identity Testing for Low Degree Unmixed $\\Sigma\\Pi\\Sigma\\Pi(k)$ Circuits

    OpenAIRE

    Huang, Jinyu

    2012-01-01

    A $\\Sigma\\Pi\\Sigma\\Pi(k)$ circuit $C=\\sum_{i=1}^kF_i=\\sum_{i=1}^k\\prod_{j=1}^{d_i}f_{ij}$ is unmixed if for each $i\\in[k]$, $F_i=f_{i1}(x_1)... f_{in}(x_n)$, where each $f_{ij}$ is a univariate polynomial given in the sparse representation. In this paper, we give a polynomial time black-box algorithm of identity testing for the low degree unmixed $\\Sigma\\Pi\\Sigma\\Pi(k)$ circuits. In order to obtain the black-box algorithm, we first show that a special class of low degree unmixed $\\Sigma\\Pi\\Si...

  4. Sigma-drop in galaxies and the sigma-metallicity degeneracy

    CERN Document Server

    Koleva, Mina; De Rijcke, Sven

    2008-01-01

    In some galaxies, the central velocity dispersion, sigma, is depressed with respect to the surroundings. This sigma-drop phenomenon may have different physical origins, bearing information about the internal dynamics of the host galaxy. In this article, we stress the importance also of observational artifacts due to the sigma-metallicity degeneracy: when a spectrum of a population is compared with a template of miss-matched metallicity, the velocity dispersion may be wrongly estimated. A sigma-drop may appear in place of a metallicity peak. The discussion is illustrated using VLT/FORS spectra of diffuse elliptical galaxies. Some of the sigma-drop galaxies reported in the literature may be analysis artifacts.

  5. Gene expression analyses implicate an alternative splicing program in regulating contractile gene expression and serum response factor activity in mice.

    Directory of Open Access Journals (Sweden)

    Twishasri Dasgupta

    Full Text Available Members of the CUG-BP, Elav-like family (CELF regulate alternative splicing in the heart. In MHC-CELFΔ transgenic mice, CELF splicing activity is inhibited postnatally in heart muscle via expression of a nuclear dominant negative CELF protein under an α-myosin heavy chain promoter. MHC-CELFΔ mice develop dilated cardiomyopathy characterized by alternative splicing defects, enlarged hearts, and severe contractile dysfunction. In this study, gene expression profiles in the hearts of wild type, high- and low-expressing lines of MHC-CELFΔ mice were compared using microarrays. Gene ontology and pathway analyses identified contraction and calcium signaling as the most affected processes. Network analysis revealed that the serum response factor (SRF network is highly affected. Downstream targets of SRF were up-regulated in MHC-CELFΔ mice compared to the wild type, suggesting an increase in SRF activity. Although SRF levels remained unchanged, known inhibitors of SRF activity were down-regulated. Conversely, we found that these inhibitors are up-regulated and downstream SRF targets are down-regulated in the hearts of MCKCUG-BP1 mice, which mildly over-express CELF1 in heart and skeletal muscle. This suggests that changes in SRF activity are a consequence of changes in CELF-mediated regulation rather than a secondary result of compensatory pathways in heart failure. In MHC-CELFΔ males, where the phenotype is only partially penetrant, both alternative splicing changes and down-regulation of inhibitors of SRF correlate with the development of cardiomyopathy. Together, these results strongly support a role for CELF-mediated alternative splicing in the regulation of contractile gene expression, achieved in part through modulating the activity of SRF, a key cardiac transcription factor.

  6. The Omitted Factor in Risk Management: Corporate Foreign Debt as an Alternative to Currency Derivatives

    DEFF Research Database (Denmark)

    Aabo, Tom

    Empirical surveys on exchange rate risk management in non-financial companies focus on the use of currency derivatives while omitting the use of corporate debt denominated in foreign currency ("foreign debt") even though the latter in risk management terms is identical to one or a series of forward...... contracts. This empirical study of the risk management practices of non-financial companies shows (1) that foreign debt is an important alternative to the use of currency derivatives, (2) that the relative importance of foreign debt compared to currency derivatives increases the longer the hedging horizon...... and the higher the uncertainty, and (3) that companies with a low solvency ratio and stable earnings attribute an especially high importance to the use of foreign debt. The study further suggests that the relative importance attributed to foreign debt differs between companies in various economic sectors....

  7. Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.

    Science.gov (United States)

    Clynes, David; Jelinska, Clare; Xella, Barbara; Ayyub, Helena; Scott, Caroline; Mitson, Matthew; Taylor, Stephen; Higgs, Douglas R; Gibbons, Richard J

    2015-01-01

    Fifteen per cent of cancers maintain telomere length independently of telomerase by the homologous recombination (HR)-associated alternative lengthening of telomeres (ALT) pathway. A unifying feature of these tumours are mutations in ATRX. Here we show that expression of ectopic ATRX triggers a suppression of the pathway and telomere shortening. Importantly ATRX-mediated ALT suppression is dependent on the histone chaperone DAXX. Re-expression of ATRX is associated with a reduction in replication fork stalling, a known trigger for HR and loss of MRN from telomeres. A G-quadruplex stabilizer partially reverses the effect of ATRX, inferring ATRX may normally facilitate replication through these sequences that, if they persist, promote ALT. We propose that defective telomere chromatinization through loss of ATRX promotes the persistence of aberrant DNA secondary structures, which in turn present a barrier to DNA replication, leading to replication fork stalling, collapse, HR and subsequent recombination-mediated telomere synthesis in ALT cancers. PMID:26143912

  8. Disc instantons in linear sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Govindarajan, Suresh E-mail: suresh@chaos.iitm.ernet.in; Jayaraman, T. E-mail: jayaram@imsc.ernet.in; Sarkar, Tapobrata E-mail: tapo@theory.tifr.res.in

    2002-12-16

    We construct a linear sigma model for open-strings ending on special Lagrangian cycles of a Calabi-Yau manifold. We illustrate the construction for the cases considered by Aganagic and Vafa (AV). This leads naturally to concrete models for the moduli space of open-string instantons. These instanton moduli spaces can be seen to be intimately related to certain auxiliary boundary toric varieties. By considering the relevant Gelfand-Kapranov-Zelevinsky (GKZ) differential equations of the boundary toric variety, we obtain the contributions to the world volume superpotential on the A-branes from open-string instantons. By using an ansatz due to Aganagic, Klemm and Vafa (AKV), we obtain the relevant change of variables from the linear sigma model to the non-linear sigma model variables--the open-string mirror map. Using this mirror map, we obtain results in agreement with those of AV and AKV for the counting of holomorphic disc instantons.

  9. Sigma Model Lagrangian for the Heisenberg Group

    CERN Document Server

    Baaquie, Belal E; Baaquie, Belal E.; Kean, Yim Kok

    2005-01-01

    We study the Lagrangian for a sigma model based on the non-compact Heisenberg group. A unique feature of this model -- unlike the case for compact Lie groups -- is that the definition of the Lagrangian has to be regulated since the trace over the Heisenberg group is otherwise divergent. The resulting theory is a real Lagrangian with a quartic interaction term. After a few non-trivial transformations, the Lagrangian is shown to be equivalent -- at the classical level -- to a complex cubic Lagrangian. A one loop computation shows that the quartic and cubic Lagrangians are equivalent at the quantum level as well. The complex Lagrangian is known to classically equivalent to the SU(2) sigma model, with the equivalence breaking down at the quantum level. An explanation of this well known results emerges from the properties of the Heisenberg sigma model.

  10. Six Sigma Driven Enterprise Model Transformation

    Directory of Open Access Journals (Sweden)

    Raymond Vella

    2009-10-01

    Full Text Available Enterprise architecture methods provide a structured system to understand enterprise activities. However, existing enterprise modelling methodologies take static views of the enterprise and do not naturally lead to a path of improvement during enterprise model transformation. This paper discusses the need for a methodology to facilitate changes for improvement in an enterprise. The six sigma methodology is proposed as the tool to facilitate progressive and continual Enterprise Model Transformation to allow businesses to adapt to meet increased customer expectation and global competition. An alignment of six sigma with phases of GERAM life cycle is described with inclusion of Critical-To-Satisfaction (CTS requirements. The synergies of combining the two methodologies are presented in an effort to provide a more culturally embedded framework for Enterprise Model Transformation that builds on the success of six sigma.

  11. Space station crew safety alternatives study. Volume 3: Safety impact of human factors

    Science.gov (United States)

    Rockoff, L. A.; Raasch, R. F.; Peercy, R. L., Jr.

    1985-01-01

    The first 15 years of accumulated space station concepts for Initial Operational Capability (IOC) during the early 1990's was considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris. Of particular interest here is volume three (of five volumes) pertaining to the safety impact of human factors.

  12. Looking for a precursor of spontaneous Sleep Slow Oscillations in human sleep: The role of the sigma activity

    Science.gov (United States)

    Allegrini, Paolo; Bedini, Remo; Bergamasco, Massimo; Laurino, Marco; Sebastiani, Laura; Gemignani, Angelo

    2016-01-01

    Sleep Slow Oscillations (SSOs), paradigmatic EEG markers of cortical bistability (alternation between cellular downstates and upstates), and sleep spindles, paradigmatic EEG markers of thalamic rhythm, are two hallmarks of sleeping brain. Selective thalamic lesions are reportedly associated to reductions of spindle activity and its spectrum ~14 Hz (sigma), and to alterations of SSO features. This apparent, parallel behavior suggests that thalamo-cortical entrainment favors cortical bistability. Here we investigate temporally-causal associations between thalamic sigma activity and shape, topology, and dynamics of SSOs. We recorded sleep EEG and studied whether spatio-temporal variability of SSO amplitude, negative slope (synchronization in downstate falling) and detection rate are driven by cortical-sigma-activity expression (12–18 Hz), in 3 consecutive 1 s-EEG-epochs preceding each SSO event (Baselines). We analyzed: (i) spatial variability, comparing maps of baseline sigma power and of SSO features, averaged over the first sleep cycle; (ii) event-by-event shape variability, computing for each electrode correlations between baseline sigma power and amplitude/slope of related SSOs; (iii) event-by-event spreading variability, comparing baseline sigma power in electrodes showing an SSO event with the homologous ones, spared by the event. The scalp distribution of baseline sigma power mirrored those of SSO amplitude and slope; event-by-event variability in baseline sigma power was associated with that in SSO amplitude in fronto-central areas; within each SSO event, electrodes involved in cortical bistability presented higher baseline sigma activity than those free of SSO. In conclusion, spatio-temporal variability of thalamocortical entrainment, measured by background sigma activity, is a reliable estimate of the cortical proneness to bistability. PMID:26003553

  13. Optimization of Coaching Using Six Sigma

    Directory of Open Access Journals (Sweden)

    Dumitru Colibaba-Evulet

    2011-01-01

    Full Text Available Problem statement: In today’s sports world, coaching and training methods are the subject of intensive competition amongst rivals. Innovative technologies, methodologies and preparation methods are employed to achieve a sustainable competitive advantage. Effective performance measurement, statistical analysis and data based decision taking have been identified as key elements towards efficient performance management. The statistical approach has been emphasized in order to fill the gaps in athlete’s preparation and improve performance. There is need to better connect the dots between the methods of statistical analysis and training and coaching methods used to improve the performance of an athlete or a team. Approach: Industry giants such as Motorola, General Electric and other improved the quality of their products through a statistically driven, six sigma methodology. Literatures in the six sigma performance measurement and improvement in industry, as well as traditional coaching in sports had been extensively reviewed. Research was carried out to establish potential application of six sigma in performance measurement and improvement in sports. Results: The six sigma approach was identified as a new method in measuring, analyzing, improving and analyzing sports performance and two examples were given. The methodology was applied on one example of data collected by authors over years of performance of a basketball team. Direction for further studies in the application of six sigma methodology in team and individual performance coaching and management were also identified. Conclusion: The results of this study determined that there is significant potential to successfully introduce the six sigma methodology of measurement, analysis and improvement in athletic performance. This new direction of analysis involved augmenting the existing traditional methods of coaching and performance management with a powerful methodology

  14. A Lean Six Sigma journey in radiology.

    Science.gov (United States)

    Bucci, Ronald V; Musitano, Anne

    2011-01-01

    The department of radiology at Akron Children's Hospital embarked on a Lean Six Sigma mission as part of a hospital wide initiative to show increased customer satisfaction, reduce employee dissatisfaction and frustration, and decrease costs. Three processes that were addressed were reducing the MRI scheduling back-log, reconciling discrepancies in billing radiology procedures, and implementing a daily management system. Keys to success is that managers provide opportunities to openly communicate between department sections to break down barriers. Executive leaders must be engaged in Lean Six Sigma for the company to be successful.

  15. A Lean Six Sigma journey in radiology.

    Science.gov (United States)

    Bucci, Ronald V; Musitano, Anne

    2011-01-01

    The department of radiology at Akron Children's Hospital embarked on a Lean Six Sigma mission as part of a hospital wide initiative to show increased customer satisfaction, reduce employee dissatisfaction and frustration, and decrease costs. Three processes that were addressed were reducing the MRI scheduling back-log, reconciling discrepancies in billing radiology procedures, and implementing a daily management system. Keys to success is that managers provide opportunities to openly communicate between department sections to break down barriers. Executive leaders must be engaged in Lean Six Sigma for the company to be successful. PMID:21793459

  16. 6 Sigma DFSS technique with easy practice

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-15

    This book describes 6 Sigma DFSS technique which is easy to use. These are the titles of the contents : new demand, the reason that DFSS needs, when is DFSS used?, DMAIC and DMADV and the bastion for achievement of 6 sigma, new trouble, chief, Chang's new store, plan on kalguksu development propel, customers are holding the key, CTQ refinement, process capability evaluation, setting goal, finding of conception of optimum design, finding of design element, the last gateway, and it's time for a DFSS!.

  17. A K3 sigma model with : symmetry

    Science.gov (United States)

    Gaberdiel, Matthias R.; Taormina, Anne; Volpato, Roberto; Wendland, Katrin

    2014-02-01

    The K3 sigma model based on the -orbifold of the D 4-torus theory is studied. It is shown that it has an equivalent description in terms of twelve free Majorana fermions, or as a rational conformal field theory based on the affine algebra . By combining these different viewpoints we show that the = (4 , 4) preserving symmetries of this theory are described by the discrete symmetry group : . This model therefore accounts for one of the largest maximal symmetry groups of K3 sigma models. The symmetry group involves also generators that, from the orbifold point of view, map untwisted and twisted sector states into one another.

  18. SIX SIGMA - A NEW APPROACH OF QUALITY

    Directory of Open Access Journals (Sweden)

    Maria Nicolai, Sofia Totolici

    2005-01-01

    Full Text Available The term six sigma was elaborated by Motorola Corp, in the early ‘80s, after a visit in Japan. The method’s application with this name has reduced the fabrication deficiencies with 99,7%, thus, in 1998, Motorola Corp. was one of the first companies to receive The Quality National Award in USA,“Malcolm Baldrige”. Then the method was used by other companies as well, which have declared that using the six sigma method, the 3,4 deficiencies per million of opportunities level may beachieved, attaining not perfection, but almost perfection.

  19. Integration of six sigma with lean production: an analysis through multiple cases

    Directory of Open Access Journals (Sweden)

    Thiago Henrique Pinheiro

    2013-08-01

    Full Text Available The intense competition between markets has taken companies, regardless of their size, to implement one or more quality improvement programs. One of the main purposes of these programs is the enhancement of company effectiveness and efficiency. There is today a growing interested in a proposal named Lean Six Sigma. Their objective is to apply six sigma concepts integrated with Lean Production. A model named Lean Six Sigma has raised interest, once its objective is to apply the concepts of the Six Sigma program integrating them with the principles of Lean Production. Six Sigma contributes with methods for problem identification, measurement and analysis, and the Lean Production offers techniques and procedures applied to reduce waste in the production. In this context, this paper aims at demonstrating the results of a field research, from which purpose was to identify relevant factors for Six Sigma implementation combined with Lean Production. To meet these objectives, three organizations from different industrial sectors were investigated. It was verified that in two of those companies, the programs were successfully implemented. Based on data analysis, it is possible to identify that one of the major difficulties encountered by the program leaders is related to the company’s human resources infra-structure. It is necessary to take into account that the conclusions are limited to a small sample of three units of analysis. However, this work offers the possibility of an analytical generalization.

  20. Perspectives in the use of tannins as alternative to antimicrobial growth promoter factors in poultry

    OpenAIRE

    Redondo, Leandro M.; Chacana, Pablo A.; Dominguez, Johana E.; Mariano Enrique Fernandez Miyakawa

    2014-01-01

    Antibiotics have been included in the formulation of feed for livestock production for more than 40 years as a strategy to improve feed conversion rates and to reduce costs. The use of antimicrobials as growth-promoting factors (AGP) in sub-therapeutic doses for long periods is particularly favorable to select antimicrobial-resistant microorganisms. In the last years, global concern about development of antimicrobial resistance and transference of resistance genes from animal to human strains...

  1. Archaeal Transcription: Function of an Alternative Transcription Factor B from Pyrococcus furiosus▿

    OpenAIRE

    Micorescu, Michael; Grünberg, Sebastian; Franke, Andreas; Cramer, Patrick; Thomm, Michael; Bartlett, Michael

    2007-01-01

    The genome of the hyperthermophile archaeon Pyrococcus furiosus encodes two transcription factor B (TFB) paralogs, one of which (TFB1) was previously characterized in transcription initiation. The second TFB (TFB2) is unusual in that it lacks recognizable homology to the archaeal TFB/eukaryotic TFIIB B-finger motif. TFB2 functions poorly in promoter-dependent transcription initiation, but photochemical cross-linking experiments indicated that the orientation and occupancy of transcription com...

  2. Alternating optimization method based on nonnegative matrix factorizations for deep neural networks

    OpenAIRE

    Sakurai, Tetsuya; Imakura, Akira; Inoue, Yuto; Futamura, Yasunori

    2016-01-01

    The backpropagation algorithm for calculating gradients has been widely used in computation of weights for deep neural networks (DNNs). This method requires derivatives of objective functions and has some difficulties finding appropriate parameters such as learning rate. In this paper, we propose a novel approach for computing weight matrices of fully-connected DNNs by using two types of semi-nonnegative matrix factorizations (semi-NMFs). In this method, optimization processes are performed b...

  3. An alternative approach for addressing the failure probability-safety factor method with sensitivity analysis

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, Enrique; Conejo, Antonio J.; Minguez, Roberto; Castillo, Carmen

    2003-11-01

    The paper introduces a method for solving the failure probability-safety factor problem for designing engineering works proposed by Castillo et al. that optimizes an objective function subject to the standard geometric and code constraints, and two more sets of constraints that simultaneously guarantee given safety factors and failure probability bounds associated with a given set of failure modes. The method uses the dual variables and is especially convenient to perform a sensitivity analysis, because sensitivities of the objective function and the reliability indices can be obtained with respect to all data values. To this end, the optimization problems are transformed into other equivalent ones, in which the data parameters are converted into artificial variables, and locked to their actual values. In this way, some variables of the associated dual problems become the desired sensitivities. In addition, using the proposed methodology, calibration of codes based on partial safety factors can be done. The method is illustrated by its application to the design of a simple rubble mound breakwater and a bridge crane.

  4. PEXSI-$\\Sigma$: A Green's function embedding method for Kohn-Sham density functional theory

    CERN Document Server

    Li, Xiantao; Lu, Jianfeng

    2016-01-01

    As Kohn-Sham density functional theory (KSDFT) being applied to increasingly more complex materials, the periodic boundary condition associated with supercell approaches also becomes unsuitable for a number of important scenarios. Green's function embedding methods allow a more versatile treatment of complex boundary conditions, and hence provide an attractive alternative to describe complex systems that cannot be easily treated in supercell approaches. In this paper, we first revisit the literature of Green's function embedding methods from a numerical linear algebra perspective. We then propose a new Green's function embedding method called PEXSI-$\\Sigma$. The PEXSI-$\\Sigma$ method approximates the density matrix using a set of nearly optimally chosen Green's functions evaluated at complex frequencies. For each Green's function, the complex boundary conditions are described by a self energy matrix $\\Sigma$ constructed from a physical reference Green's function, which can be computed relatively easily. In th...

  5. Pion Effect of Nuclear Matter in a Chiral Sigma Model

    Institute of Scientific and Technical Information of China (English)

    HU Jin-niu; Y.Ogawa; H.Toki; A.Hosaka; SHEN Hong

    2009-01-01

    We develop a new framework for the study of the nuclear matter based on the linear sigma model.We introduce a completely new viewpoint on the treatment of the nuclear matter with the inclusion of the pion.We extend the relativistic chiral mean field model by using the similar method in the tensor optimized shell model.We also regulate the pion-nucleon interaction by considering the form-factor and short range repulsion effects.We obtain the equation of state of nuclear matter and study the importance of the pion effect.

  6. Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration.

    Directory of Open Access Journals (Sweden)

    Devi Krishna Priya Karunakaran

    Full Text Available Age-related macular degeneration (AMD is the most common cause of blindness in the elderly population. Hypoxic stress created in the micro-environment of the photoreceptors is thought to be the underlying cause that results in the pathophysiology of AMD. However, association of AMD with alternative splicing mediated gene regulation is not well explored. Alternative Splicing is one of the primary mechanisms in humans by which fewer protein coding genes are able to generate a vast proteome. Here, we investigated the expression of a known stress response gene and an alternative splicing factor called Serine-Arginine rich splicing factor 10 (Sfrs10. Sfrs10 is a member of the serine-arginine (SR rich protein family and is 100% identical at the amino acid level in most mammals. Immunoblot analysis on retinal extracts from mouse, rat, and chicken showed a single immunoreactive band. Further, immunohistochemistry on adult mouse, rat and chicken retinae showed pan-retinal expression. However, SFRS10 was not detected in normal human retina but was observed as distinct nuclear speckles in AMD retinae. This is in agreement with previous reports that show Sfrs10 to be a stress response gene, which is upregulated under hypoxia. The difference in the expression of Sfrs10 between humans and lower mammals and the upregulation of SFRS10 in AMD is further reflected in the divergence of the promoter sequence between these species. Finally, SFRS10+ speckles were independent of the SC35+ SR protein speckles or the HSF1+ stress granules. In all, our data suggests that SFRS10 is upregulated and forms distinct stress-induced speckles and might be involved in AS of stress response genes in AMD.

  7. Implementation of Lean Six Sigma in small- and medium-sized manufacturing enterprises in the Netherlands

    NARCIS (Netherlands)

    Timans, W.; Antony, J.; Ahaus, K.; van Solingen, R.

    2012-01-01

    In this paper we provide an exploration and analysis of Lean Six Sigma (LSS) implementation in Dutch manufacturing/engineering small- and medium-sized enterprises (SMEs). Critical success factors (CSFs) and impeding factors are identified and analysed. Exploratory empirical evidence about LSS implem

  8. Loneliness and solitude in adolescence: A confirmatory factor analysis of alternative models

    DEFF Research Database (Denmark)

    Goossens, Luc; Lasgaard, Mathias; Luyckx, Koen;

    2009-01-01

    The present study tested a four-factor model of adolescent loneliness and solitude that comprises peer-related loneliness, family loneliness, negative attitude toward solitude, and positive attitude toward solitude. Nine different instruments for a total of 14 scales and derivative subscales were...... of the Loneliness and Aloneness Scale for Children and Adolescents (LACA) is recommended, because the instrument measures all four aspects of the model. Implications for current theories on adolescent loneliness and associated phenomena, such as adolescents' attitude toward being on their own, are briefly discussed....

  9. Analog circuit design structured mixed-mode design, multi-bit sigma-delta converters, short range RF circuits

    CERN Document Server

    van Roermund, Arthur

    2007-01-01

    Preface. Part I: Structured Mixed-Mode Design. Introduction. Structured Oscillator Design; C. Verhoeven, A. van Staveren. Systematic Design of High-frequency gm-C Filters; E. Lauwers, G. Gielen. Structured LNA Design; E.H. Nordholt. High-Level Simulation and Modeling Tools for Mixed-Signal Front-ends of Wireless Systems; P. Wambacq, et al. Structured Simulation-Based Analog Design Synthesis; R.A. Rutenbar. Structured Analog layout Design; K. Lampaert. Part II: Multi-Bit Sigma Delta Converters. Introduction. Architecture Considerations for Multi-Bit SigmaDelta ADCs; T. Brooks. Multirate Sigma-Delta Modulators, an Alternative to Multibit; F. Colodro, A. Torralba. Circuit Design Aspects of Multi-Bit Delta-Sigma Converters; Y. Geerts, et al. High-speed Digital to Analog Converter Issues with Applications to Sigma Delta Modulators; K. Doris, et al. Correction-Free Multi-Bit Sigma-Delta Modulators for ADSL; R. del Rio, et al. Sigma Delta Converters in Wireline Communications; A. Wiesbauer, et al. Part III: Short Ra...

  10. Sigma-models and Homotopy Algebras

    CERN Document Server

    Zeitlin, Anton M

    2015-01-01

    We review the relation between homotopy algebras of conformal field theory and geometric structures arising in sigma models. In particular we formulate conformal invariance conditions, which in the quasi-classical limit are Einstein equations with extra fields, as generalized Maurer-Cartan equations.

  11. Lean Six Sigma: Stap voor stap

    NARCIS (Netherlands)

    R.J.M.M. Does; H. de Koning; J. de Mast

    2008-01-01

    Lean Six Sigma is de culminatie van ontwikkelingen in kwaliteitsverbetering in de 20ste eeuw. Het combineert belangrijke principes en technieken in een goed gestructureerde en geïntegreerde benadering. Het belichaamt wetenschappelijke inzichten over onderzoeksmethodologie, management en economie. In

  12. The science of Six Sigma in hospitals.

    Science.gov (United States)

    Guinane, Carole S; Davis, Noreen H

    2004-01-01

    Six Sigma applied to hospital processes and services can lead to breakthrough improvements, near-perfect outcomes, and zero defects. It is wise to consider this aspect of quality science as part of an overall Total Quality Management program. Senior leadership support and involvement is critical to the success of this strategy. PMID:15604839

  13. How Six Sigma Methodology Improved Doctors' Performance

    Science.gov (United States)

    Zafiropoulos, George

    2015-01-01

    Six Sigma methodology was used in a District General Hospital to assess the effect of the introduction of an educational programme to limit unnecessary admissions. The performance of the doctors involved in the programme was assessed. Ishikawa Fishbone and 5 S's were initially used and Pareto analysis of their findings was performed. The results…

  14. Lean Six Sigma for Service and Healthcare

    NARCIS (Netherlands)

    J. de Mast; R.J.M.M. Does; H. de Koning

    2006-01-01

    Lean Six Sigma is built on principles and methods that have proven themselves over the twentieth century. It has incorporated the most effective approaches and integrated them into a full programme. It offers a management structure for organizing continuous improvement of routine tasks, such as manu

  15. The Scientific Underpinning of Lean Six Sigma

    NARCIS (Netherlands)

    R.J.M.M. Does; J. de Mast; H. de Koning; S. Bisgaard

    2007-01-01

    The twentieth century saw an incredible development of professional organizations. The impact of technological advances is obvious, but besides these, innovations in management structures and methods have resulted in the highly productive organizations of today. Lean Six Sigma is not revolutionary.

  16. Improving Learning Outcome Using Six Sigma Methodology

    Science.gov (United States)

    Tetteh, Godson A.

    2015-01-01

    Purpose: The purpose of this research paper is to apply the Six Sigma methodology to identify the attributes of a lecturer that will help improve a student's prior knowledge of a discipline from an initial "x" per cent knowledge to a higher "y" per cent of knowledge. Design/methodology/approach: The data collection method…

  17. Six Sigma and Introductory Statistics Education

    Science.gov (United States)

    Maleyeff, John; Kaminsky, Frank C.

    2002-01-01

    A conflict exists between the way statistics is practiced in contemporary business environments and the way statistics is taught in schools of management. While businesses are embracing programs, such as six sigma and TQM, that bring statistical methods to the forefront of management decision making, students do not graduate with the skills to…

  18. Janez Rugelj's alternative therapeutic community after the five-factor model of personality

    Directory of Open Access Journals (Sweden)

    Judita Bagon

    2000-12-01

    Full Text Available The Alternative Therapeutic Community (ATC of Dr. J. Rugelj is a specific social community consisting of people in distress (always consisting of about 120 people, who have all been handicapped in their lives in one way or another. The group is also specific because of their way towards recovery, i.e., intensively reactivating the mecanisms of healthy life to surmount their psychical and social deficiency. The results of measuring the structure of personality according to BFQ – the "Big Five" model of personality – show that the ATC as a whole achieves lower scores than the normal population on all dimensions and subdimensions. The difference is statistically significant regarding the dimension of Emotional stability as well as the subdimension Emotional control. The ATC is not a uniform group, so the results differ according to the diagnosis. The members with the diagnosis of 'a neurotic' or 'a psychotic' achieve below-average results, while the accompanying members achieve similar results as the control group (selected from the non-members of the ATC. The results of the members diagnosed as 'an alcoholic' are somewhat surprising – they do not differ considerably on any dimension or subdimension from the results achieved by the control group – not even on the Emotional stability scale. As regards the total period of staying in the program, the results of subdimensions remain mostly unchanged. However, during the time spent in the program the results on the subdimensions change: the group which has been in the program for 1 to 2 years generally scores higher than the group of beginners (the difference is statistically significant only for the dimension Emotional control, but the results of the group participating in the program for longer time (more than three years are lower again, until they stabilize in the central position (T=50. The results on theHonesty scale (which may also show positive or negative self-image show no

  19. Modelo de referência para estruturar o Seis Sigma nas organizações Reference model to structure the Six Sigma in organizations

    Directory of Open Access Journals (Sweden)

    Adriana Barbosa Santos

    2008-04-01

    Full Text Available Este artigo apresenta o modelo de referência para estruturar o Seis Sigma, o qual é resultante da incorporação de teorias que contribuem para aumentar o potencial estratégico do Seis Sigma no sentido de incrementar o desempenho organizacional. Em sua proposta, o modelo de referência engloba um direcionamento sobre certos requisitos primordiais para o sucesso do programa Seis Sigma. A base teórica de sustentação do modelo de referência foi construída a partir de estudos sobre a influência dos seguintes fatores: orientação estratégica e alinhamento estratégico; medição e gerenciamento do desempenho organizacional; uso de estatística (pensamento estatístico; capacitação/especialização de pessoas; implementação e gerenciamento de projetos; e uso de tecnologia de informação. Complementando a proposição do modelo, o artigo traz evidências empíricas acerca da contribuição dos fatores identificados na formulação do modelo de referência, expondo resultados decorrentes de estudos de caso realizados em quatro subsidiárias brasileiras de multinacionais de grande porte. A análise dos dados forneceu evidências positivas de que os fatores mencionados influenciam de forma efetiva o sucesso e a consolidação do Seis Sigma nas empresas estudadas.This paper introduces the reference model to structure Six Sigma. This model is a result of theory incorporation that contributes to increase the strategic power of Six Sigma for improving businesses performance. Reference model proposal points out certain primordial requirements for de Six Sigma program success. The theoretical basis to sustain the reference model was supported in studies about the influence of critical factors such as: strategic orientation and strategic alignment; business performance measurement; statistical approach (statistical thinking; people training; project implementation; and information technology use. Complementing the model proposition, this paper

  20. A literary study on the bonding of the Six Sigma with the Service Quality for the enrichment of the Service Sector(S) for the Construction Projects

    OpenAIRE

    R.Surya Kiran; Vikas Kumar Singh

    2014-01-01

    Purpose: This research paper focusses on the merger of the six sigma with the service quality for the improvement of the services for the service sectors . Approach: This paper approaches towards the resaons for the poor performance of the six sigma in the service sectors ,key factors necessary for the implementation of the six sigma and the barriers / difficulties to the implementation of the same . Findings: This paper drives towards the problems ,outcomes and the benefits...

  1. A New Measurement of the Masses and Widths of the Sigma_c^*++ and Sigma_c^*0 Charmed Baryons

    CERN Document Server

    Athar, S B; Breva-Newell, L; Patel, R; Potlia, V; Stöck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Wiss, J; Edwards, K W; Besson, D; Pedlar, T K; Gao, K Y; Gong, D T; Kubota, Y; Lang, B W; Li, S Z; Poling, R A; Scott, A W; Smith, A; Stepaniak, C J; Dobbs, S; Metreveli, Z V; Seth, K K; Tomaradze, A G; Zweber, P; Ernst, J; Mahmood, A H; Severini, H; Asner, D M; Dytman, S A; Love, W; Mehrabyan, S S; Müller, J A; Savinov, V; Li, Z; López, A; Méndez, H; Ramírez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shibata, E I; Shipsey, I P J; Adams, G S; Chasse, M; Cravey, M; Cummings, J P; Danko, I; Napolitano, J; Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dambasuren, E; Dorjkhaidav, O; Menaa, N; Mountain, R; Muramatsu, H; Nandakumar, R; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Bornheim, A; Pappas, S P; Weinstein, A J; Rosner, J L; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G T; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Credé, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Stroiney, S; Sun, W M; Thayer, J G; Urner, D; Wilksen, T; Weinberger, M

    2004-01-01

    Using data recorded by the CLEO III detector at CESR, we have made measurements of some properties of the Sigma_c^{*++} and Sigma_c^{*0} charmed baryons. In particular: Gamma(Sigma_c^{*++})=14.4^{+1.6}_{-1.5}+-1.4 MeV, M(Sigma_c^{*++})-M(Lambda_c^+) = 231.5+-0.4+-0.3 MeV, Gamma(Sigma_c^{*0})=16.6^{+1.9}_{-1.7}+-1.4 MeV, M(Sigma_c^{*0})-M(Lambda_c^+) = 231.4+-0.5+-0.3 MeV.

  2. Quasifree Electroproduction of Lambda, Sigma0, and sigma-Hyperons on Carbon and Aluminum

    Energy Technology Data Exchange (ETDEWEB)

    Wendy Hinton

    2001-05-01

    The first study of (e,e',K+) on carbon and aluminum was performed at Thomas Jefferson National Accelerator Facility (Jefferson Lab) using the Continuous Electron Beam Accelerator Facility (CEBAF). The scattered electron and electroproduced kaon were detected in coincidence in the Hall C End Station using the High Momentum Spectrometer and Short Orbit Spectrometer. The quasifree production of the Lambda, Sigma0, and Sigma- hyperons was studied. The Lambda-dependence of the effective nucleon number was obtained. The cross section data were fit to a power law ({approx}Aa) with a = 0.88 +/- 0.10, consistent with the K+'s relatively long nuclear mean free path. A large enhancement in the Sigma0+Sigma- / Lambda ratio is seen. A feasibility test for hypernuclear spectroscopy on C-12 and Al-27 with the HMS-SOS was performed.

  3. Heritability of dimensions of Eysenck's pen model and the alternative five-factor model of personality

    Directory of Open Access Journals (Sweden)

    Smederevac Snežana

    2006-01-01

    Full Text Available The main aim of this study is to estimate the heritability of AFFM and PEN dimensions, including 67 pairs of twins (34 monozygotic and 33 dizygotic of both genders, aged 18 - 44. The heritability has been estimated by the biometric method, two full (ACE and ADE and three reduced (AE, DE and CE models tested for each personality trait. Taking into consideration the AFFM dimensions, additive genetic factors and a non-shared environment contribute the most significantly to the phenotypic variation of activity, sociability and the impulsive sensation seeking; anxiety and aggressiveness are best accounted for by the dominant genetic effects. In the PEN domain, fit indicators suggest that ACE and the reduced AE models provide the best explanation for the phenotypic manifestations of neuroticism, while ACE and CE models account for the variation of L scale. Although the fit indicators calculated for extraversion and psychotic behavior are somewhat problematic, the parameter estimates show that extraversion is best accounted for by the additive genetic variance, shared environmental effects, and the non-shared environment, whereas psychotic behavior is the most adequately explained by both shared and non-shared environmental effects.

  4. Contribution of Sigma B to environmental stress tolerance in Listeria monocytogenes-A review%Sigma B在单核细胞增生李斯特菌耐受环境压力胁迫中的作用

    Institute of Scientific and Technical Information of China (English)

    张强; 冯莹颖; 周青春; 罗勤; 张晓莉; 秦龙娟

    2009-01-01

    The alternative sigma factor Sigma B plays important roles in both virulence and stress tolerance in Listeria monocytogenes . It is now clear that there is a strong link between the virulence potential of Listeria monocytogenes and its ability to tolerate stress. Several studies have identified genes that play important roles in stress tolerance and virulence. For example, genes involved in osmotic stress tolerance, acid and alkaline tolerance,oxidative stress tolerance, extreme temperature tolerance, and bile salt tolerance have all been implicated in the virulence of L . monocytogenes . We reviewed the role of Sigma B in several environmental stress conditions to understand the physical character of this microorganism, to discuss the best preservation conditions of food, and to prevent bacterial infection.%Sigma B(σ~B)因子在单核细胞增生李斯特菌(Listeria monocytogenes)的压力应答和毒力调控中起着重要的作用.研究发现单核细胞增生李斯特菌的致病力与耐受环境条件的胁迫息息相关.在压力存在的情况下能启动一些基因的表达,以增强细菌对环境的耐受性,这些基因包括与耐受渗透压、酸碱性环境、氧化、极端温度和宿主体内胆碱等环境压力相关的基因.本文综述了σ~B因子在上述几种环境压力胁迫中的作用,为深入了解该菌的生理特征、探讨食品的最佳生产和保藏条件、防止细菌的感染等方面提供新的理论依据.

  5. SIX SIGMA: A METRIC, A METHODOLOGY AND A MANAGEMENT SYSTEM

    Directory of Open Access Journals (Sweden)

    Mureşan Ioana

    2010-07-01

    Full Text Available This article is a theoretical article regarding Six Sigma. Six Sigma has been interpreted over time within quality theory as a metric, methodology or a management system. We explain Six Sigma using a logistics context: Delivery-On-Time (DOT rate problem. It is a theoretical context useful both for academic users and practitioners. At the beginning of the paper the DOT problem is generally described, while Sigma is presented according to statisticians view in the second part of the paper. Six Sigma is then presented as a metric for process’ capability. The fourth part of this article contains details regarding Six Sigma usage as a methodology for improvement, while the fifth part of this article refers to Six Sigma as a management system which can be used at firms’ level. The last chapter is dedicated to conclusions regarding the possible use of Six Sigma in Romania.

  6. The sigma receptor: evolution of the concept in neuropsychopharmacology.

    Science.gov (United States)

    Hayashi, T; Su, Tp

    2005-10-01

    Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor is a 25-kDa protein possessing one putative transmembrane domain and an endoplasmic reticulum retention signal. Sigma-1 receptors are highly expressed in deeper laminae of the cortex, olfactory bulb, nuclei of mesencephalon, hypothalamus, and Purkinje cells in the brain. Sigma-1 receptors are predominantly localized at the endoplasmic reticulum of both neurons and oligodendrocytes. From behavioral studies, sigma-1 receptors were shown to be involved in higher-ordered brain functions including memory and drug dependence. The actions mediated by sigma-1 receptors at the cellular level can be considered either as acute or chronic. The acute actions include the modulation of ion channels (i.e., K+ channel, NMDA receptors, IP3 receptors) and the sigma-1 receptor translocation. Chronic actions of sigma-1 receptors are basically considered to be the result of an up- or down regulation of the sigma-1 receptor itself. For example, the upregulation of sigma-1 receptors per se, even without exogenous ligands, promotes cellular differentiation and reconstitution of lipid microdomains (lipid rafts) in cultured cells. These findings together suggest that sigma-1 receptors might possess a constitutive biological activity, and that sigma-1 receptor ligands might merely work as modulators of the innate activity of this protein. Recent in vitro and in vitro studies strongly point to the possibility that sigma-1 receptors participate in membrane remodeling and cellular differentiation in the nervous system.

  7. Six Sigma methods applied to cryogenic coolers assembly line

    Science.gov (United States)

    Ventre, Jean-Marc; Germain-Lacour, Michel; Martin, Jean-Yves; Cauquil, Jean-Marc; Benschop, Tonny; Griot, René

    2009-05-01

    Six Sigma method have been applied to manufacturing process of a rotary Stirling cooler: RM2. Name of the project is NoVa as main goal of the Six Sigma approach is to reduce variability (No Variability). Project has been based on the DMAIC guideline following five stages: Define, Measure, Analyse, Improve, Control. Objective has been set on the rate of coolers succeeding performance at first attempt with a goal value of 95%. A team has been gathered involving people and skills acting on the RM2 manufacturing line. Measurement System Analysis (MSA) has been applied to test bench and results after R&R gage show that measurement is one of the root cause for variability in RM2 process. Two more root causes have been identified by the team after process mapping analysis: regenerator filling factor and cleaning procedure. Causes for measurement variability have been identified and eradicated as shown by new results from R&R gage. Experimental results show that regenerator filling factor impacts process variability and affects yield. Improved process haven been set after new calibration process for test bench, new filling procedure for regenerator and an additional cleaning stage have been implemented. The objective for 95% coolers succeeding performance test at first attempt has been reached and kept for a significant period. RM2 manufacturing process is now managed according to Statistical Process Control based on control charts. Improvement in process capability have enabled introduction of sample testing procedure before delivery.

  8. Operational excellence (six sigma) philosophy: Application to software quality assurance

    Energy Technology Data Exchange (ETDEWEB)

    Lackner, M.

    1997-11-01

    This report contains viewgraphs on operational excellence philosophy of six sigma applied to software quality assurance. This report outlines the following: goal of six sigma; six sigma tools; manufacturing vs administrative processes; Software quality assurance document inspections; map software quality assurance requirements document; failure mode effects analysis for requirements document; measuring the right response variables; and questions.

  9. Incorporating Six Sigma Methodology Training into Chemical Engineering Education

    Science.gov (United States)

    Dai, Lenore L.

    2007-01-01

    Six Sigma is a buzz term in today's technology and business world and there has been increasing interest to initiate Six Sigma training in college education. We have successfully incorporated Six Sigma methodology training into a traditional chemical engineering course, Engineering Experimentation, at Texas Tech University. The students have…

  10. On gauged linear sigma models with torsion

    CERN Document Server

    Crichigno, P Marcos

    2015-01-01

    We study a broad class of two dimensional gauged linear sigma models (GLSMs) with off-shell N=(2,2) supersymmetry that flow to nonlinear sigma models (NLSMs) on noncompact geometries with torsion. These models arise from coupling chiral, twisted chiral, and semichiral multiplets to known as well as to a new N=(2,2) vector multiplet, the constrained semichiral vector multiplet (CSVM). We discuss three kinds of models, corresponding to torsionful deformations of standard GLSMs realizing Kahler, hyperkahler, and Calabi-Yau manifolds. The (2,2) supersymmetry guarantees that these spaces are generalized Kahler. Our analysis of the geometric structure is performed at the classical level, but we also discuss quantum aspects such as R-symmetry anomalies. We provide an explicit example of a generalized Kahler structure on the conifold.

  11. Non-compact nonlinear sigma models

    Science.gov (United States)

    de Rham, Claudia; Tolley, Andrew J.; Zhou, Shuang-Yong

    2016-09-01

    The target space of a nonlinear sigma model is usually required to be positive definite to avoid ghosts. We introduce a unique class of nonlinear sigma models where the target space metric has a Lorentzian signature, thus the associated group being non-compact. We show that the would-be ghost associated with the negative direction is fully projected out by 2 second-class constraints, and there exist stable solutions in this class of models. This result also has important implications for Lorentz-invariant massive gravity: There exist stable nontrivial vacua in massive gravity that are free from any linear vDVZ-discontinuity and a Λ2 decoupling limit can be defined on these vacua.

  12. Non-compact nonlinear sigma models

    CERN Document Server

    de Rham, Claudia; Zhou, Shuang-Yong

    2015-01-01

    The target space of a nonlinear sigma model is usually required to be positive definite to avoid ghosts. We introduce a unique class of nonlinear sigma models where the target space metric has a Lorentzian signature, thus the associated group being non-compact. We show that the would-be ghost associated with the negative direction is fully projected out by 2 second-class constraints, and there exist stable solutions in this class of models. This result also has important implications for Lorentz--invariant massive gravity: There exist stable nontrivial vacua in massive gravity that are free from any linear vDVZ--discontinuity and a $\\Lambda_2$ decoupling limit can be defined on these vacua.

  13. Supersymmetry-breaking nonlinear sigma models

    Energy Technology Data Exchange (ETDEWEB)

    Imai, Takumi, E-mail: imai@yukawa.kyoto-u.ac.jp [Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606-8502 (Japan); Izawa, K.-I. [Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606-8502 (Japan); Kavli Institute for the Physics and Mathematics of the Universe, University of Tokyo (WPI), Kashiwa 277-8583 (Japan); Nakai, Yuichiro [Department of Physics, Tohoku University, Sendai 980-8578 (Japan)

    2012-10-22

    We consider a novel class of constraints on chiral superfields to obtain supersymmetric nonlinear sigma models in four spacetime dimensions, which strictly combine the internal symmetry breaking with spontaneous supersymmetry breaking. The resultant massless modes can be exclusively Nambu-Goldstone bosons without their complex partners and the goldstino that is charged under the internal symmetry. The massive modes show a peculiar relation among their masses and the scales of symmetry breakings.

  14. Applying Six Sigma in foodservice organizations

    OpenAIRE

    Kivela, Jaksa; Kagi, Jacky

    2009-01-01

    This study investigated how a large foodservice organization successfully adopted the Six Sigma quality system from other industry applications in their foodservice environment. In addition, the study explored how different levels of the organization had contributed to the application and the perceived importance of such system within the organization. Review of the recent foodservice lite-rature suggested that quality service research is important because it is directly linked to customer sa...

  15. Six Sigma Implementation at Bharti Infotel

    OpenAIRE

    Archana Shukla; Srinivasan, R.

    2007-01-01

    Bharti Airtel Limited was a leading private sector provider of telecommunication services in India, with a customer base of 8.73 million as of July 2004. The company had two branch companies — Bharti Infotel (that dealt with fixed line, long distance, and enterprise services) and Bharti Cellular (that dealt with mobile telephone services). This case is about the six sigma implementation at Bharti Infotel.The case briefly discusses the business imperatives in the fast changing Indian telecommu...

  16. Non-Linear Sigma Model on Conifolds

    CERN Document Server

    Parthasarathy, R

    2002-01-01

    Explicit solutions to the conifold equations with complex dimension $n=3,4$ in terms of {\\it{complex coordinates (fields)}} are employed to construct the Ricci-flat K\\"{a}hler metrics on these manifolds. The K\\"{a}hler 2-forms are found to be closed. The complex realization of these conifold metrics are used in the construction of 2-dimensional non-linear sigma model with the conifolds as target spaces. The action for the sigma model is shown to be bounded from below. By a suitable choice of the 'integration constants', arising in the solution of Ricci flatness requirement, the metric and the equations of motion are found to be {\\it{non-singular}}. As the target space is Ricci flat, the perturbative 1-loop counter terms being absent, the model becomes topological. The inherent U(1) fibre over the base of the conifolds is shown to correspond to a gauge connection in the sigma model. The same procedure is employed to construct the metric for the resolved conifold, in terms of complex coordinates and the action ...

  17. Planetary companion in K giant Sigma Persei

    CERN Document Server

    Lee, Byeong-Cheol; Park, Myeong-Gu; Mkrtichian, David E; Jeong, Gwanghui; Kim, Kang-Min; Valyavin, Gennady

    2014-01-01

    We report the detection of an exoplanet candidate in orbit around sigma Persei from a radial velocity (RV) survey. The system exhibits periodic RV variations of 579.8 +/- 2.4 days. The purpose of the survey is to search for low-amplitude and long-period RV variations in giants and examine the origin of the variations using the fiber-fed Bohyunsan Observatory Echelle Spectrograph installed at the 1.8-m telescope of Bohyunsan Optical Astronomy Observatory in Korea. We present high-accuracy RV measurements of sigma Per made from December 2003 to January 2014. We argue that the RV variations are not related to the surface inhomogeneities but instead a Keplerian motion of the planetary companion is the most likely explanation. Assuming a stellar mass of 2.25 +/- 0.5 M_Sun, we obtain a minimum planetary companion mass of 6.5 +/- 1.0 M_Jup, with an orbital semi-major axis of 1.8 +/- 0.1 AU, and an eccentricity of 0.3 +/- 0.1 around sigma Per.

  18. A structural model of anti-anti-[sigma] inhibition by a two-component receiver domain: the PhyR stress response regulator

    Energy Technology Data Exchange (ETDEWEB)

    Herrou, Julien; Foreman, Robert; Fiebig, Aretha; Crosson, Sean (UC)

    2012-05-09

    PhyR is a hybrid stress regulator conserved in {alpha}-proteobacteria that contains an N-terminal {sigma}-like (SL) domain and a C-terminal receiver domain. Phosphorylation of the receiver domain is known to promote binding of the SL domain to an anti-{sigma} factor. PhyR thus functions as an anti-anti-{sigma} factor in its phosphorylated state. We present genetic evidence that Caulobacter crescentus PhyR is a phosphorylation-dependent stress regulator that functions in the same pathway as {sigma}{sup T} and its anti-{sigma} factor, NepR. Additionally, we report the X-ray crystal structure of PhyR at 1.25 {angstrom} resolution, which provides insight into the mechanism of anti-anti-{sigma} regulation. Direct intramolecular contact between the PhyR receiver and SL domains spans regions {sigma}{sub 2} and {sigma}{sub 4}, likely serving to stabilize the SL domain in a closed conformation. The molecular surface of the receiver domain contacting the SL domain is the structural equivalent of {alpha}4-{beta}5-{alpha}5, which is known to undergo dynamic conformational change upon phosphorylation in a diverse range of receiver proteins. We propose a structural model of PhyR regulation in which receiver phosphorylation destabilizes the intramolecular interaction between SL and receiver domains, thereby permitting regions {sigma}{sub 2} and {sigma}{sub 4} in the SL domain to open about a flexible connector loop and bind anti-{sigma} factor.

  19. A structural model of anti-anti-[sigma];#963; inhibition by a two-component receiver domain: the PhyR stress response regulator

    Energy Technology Data Exchange (ETDEWEB)

    Herrou, Julien; Foreman, Robert; Fiebig, Aretha; Crosson, Sean (UC)

    2012-03-30

    PhyR is a hybrid stress regulator conserved in {alpha}-proteobacteria that contains an N-terminal {sigma}-like (SL) domain and a C-terminal receiver domain. Phosphorylation of the receiver domain is known to promote binding of the SL domain to an anti-{sigma} factor. PhyR thus functions as an anti-anti-{sigma} factor in its phosphorylated state. We present genetic evidence that Caulobacter crescentus PhyR is a phosphorylation-dependent stress regulator that functions in the same pathway as {sigma}{sup T} and its anti-{sigma} factor, NepR. Additionally, we report the X-ray crystal structure of PhyR at 1.25 {angstrom} resolution, which provides insight into the mechanism of anti-anti-{sigma} regulation. Direct intramolecular contact between the PhyR receiver and SL domains spans regions {sigma}{sub 2} and {sigma}{sub 4}, likely serving to stabilize the SL domain in a closed conformation. The molecular surface of the receiver domain contacting the SL domain is the structural equivalent of {alpha}4-{beta}5-{alpha}5, which is known to undergo dynamic conformational change upon phosphorylation in a diverse range of receiver proteins. We propose a structural model of PhyR regulation in which receiver phosphorylation destabilizes the intramolecular interaction between SL and receiver domains, thereby permitting regions {sigma}{sub 2} and {sigma}{sub 4} in the SL domain to open about a flexible connector loop and bind anti-{sigma} factor.

  20. K^0 pi^0 Sigma^+ and K^*0 Sigma^+ photoproduction off the proton

    CERN Document Server

    Nanova, M; Bantes, B; Bartholomy, O; Bayadilov, D; Beck, R; Beloglasov, Yu A; Castelijns, R; Credé, V; Dutz, H; Ehmanns, A; Elsner, D; Essig, K; Ewald, R; Fabry, I; Fornet-Ponse, K; Fuchs, M; Funke, C; Gothe, R; Gregor, R; Gridnev, A B; Gutz, E; Hoffmeister, P; Horn, I; Jaegle, I; Junkersfeld, J; Kalinowsky, H; Kammer, S; Kleber, V; Klein, Frank; Klein, Friedrich; Klempt, E; Konrad, M; Kotulla, M; Krusche, B; Lang, M; Langheinrich, J; Löhner, H; Lopatin, I V; Lotz, J; Lugert, S; Menze, D; Messchendorp, J G; Mertens, T; Metag, V; Morales, C; Novinski, D V; Novotny, R; Ostrick, M; Pant, L M; Van Pee, H; Pfeiffer, M; Radkov, A; Roy, A; Schadmand, S; Schmidt, C; Schmieden, H; Schoch, B; Shende, S V; Sokhoyan, V; Sule, A; Sumachev, V V; Szczepanek, T; Thoma, U; Trnka, D; Varma, R; Walther, D; Weinheimer, C; Wendel, C

    2008-01-01

    The exclusive reactions $\\gamma p \\to K^{*0} \\Sigma^+(1189)$ and $\\gamma p \\to K^{0} \\pi^{0}\\Sigma^+(1189)$, leading to the p 4$\\pi^{0}$ final state, have been measured with a tagged photon beam for incident energies from threshold up to 2.5 GeV. The experiment has been performed at the tagged photon facility of the ELSA accelerator (Bonn). The Crystal Barrel and TAPS detectors were combined to a photon detector system of almost 4$\\pi$ geometrical acceptance. Differential and total cross sections are reported. At energies close to the threshold, a flat angular distribution has been observed for the reaction $\\gamma p\\to K^{0} \\pi^{0}\\Sigma^+$ suggesting dominant s-channel production. $\\Sigma^*(1385)$ and higher lying hyperon states have been observed. An enhancement in the forward direction in the angular distributions of the reaction $\\gamma p \\to K^{*0}\\Sigma^+$ indicates a $t$-channel exchange contribution to the reaction mechanism. The experimental data are in reasonable agreement with recent theoretical ...

  1. First Observation of Heavy Baryons \\Sigma_b and \\Sigma_b^*

    CERN Document Server

    Aaltonen, T; Adelman, J; Affolder, T; Akimoto, T; Albrow, M G; Amerio, S; Amidei, D; Anastassov, A; Anikeev, K; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, P H; Bedeschi, F; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, R E; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bölla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, Yu A; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, K L; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carillo, S; Carlsmith, D; Carosi, R; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, S H; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, I; Cho, K; Chokheli, D; Chou, J P; Choudalakis, G; Chuang, S H; Chung, K; Chung, W H; Chung, Y S; Cilijak, M; Ciobanu, C I; Ciocci, M A; Clark, A; Clark, D; Coca, M; Compostella, G; Convery, M E; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Cuenca-Almenar, C; Cuevas-Maestro, J; Culbertson, R; Cully, J C; Da Ronco, S; Datta, M; D'Auria, S; Davies, T; Dagenhart, D; De Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'Orso, Mauro; Delli Paoli, F; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, P F; Di Giovanni, G P; Dionisi, C; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Dorr, C; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, H C; Farrington, S; Fedorko, I; Fedorko, W T; Feild, R G; Feindt, M; Fernández, J P; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, J C; Furic, I; Gallinaro, M; Galyardt, J; García, J E; Garberson, F; Garfinkel, A F; Gay, C; Gerberich, H; Gerdes, D; Giagu, S; Giannetti, P; Gibson, K; Gimmell, J L; Ginsburg, C; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Goldstein, J; Golossanov, A; Gómez, G; Gómez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, R C; Grundler, U; Guimarães da Costa, J; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, S R; Halkiadakis, E; Hamilton, A; Han, B Y; Han, J Y; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, R F; Harris, R M; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hidas, D; Hill, C S; Hirschbuehl, D; Höcker, A; Holloway, A; Hou, S; Houlden, M; Hsu, S C; Huffman, B T; Hughes, R E; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jang, D; Jayatilaka, B; Jeans, D; Jeon, E J; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Jung, J E; Junk, T R; Kamon, T; Karchin, P E; Kato, Y; Kemp, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, B R; Kondo, K; Kong, D J; Konigsberg, J; Korytov, A; Kotwal, A V; Kraan, A C; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, S E; Kuhr, T; Kulkarni, N P; Kusakabe, Y; Kwang, S; Laasanen, A T; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, Y J; Lee, S W; Lefèvre, R; Leonardo, N; Leone, S; Levy, S; Lewis, J D; Lin, C; Lin, C S; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, T; Lockyer, N S; Loginov, A; Loreti, M; Lu, R S; Lucchesi, D; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Mäki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marginean, R; Marino, C; Marino, C P; Martin, A; Martin, M; Martin, V; Martínez, M; Martinez-Ballarin, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Matsunaga, H; Mattson, M E; Mazini, R; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtälä, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyamoto, A; Moed, S; Moggi, N; Mohr, B; Moon, C S; Moore, R; Morello, M; Movilla-Fernández, P A; Mülmenstädt, J; Mukherjee, A; Müller, T; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norniella, O; Nurse, E; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Österberg, K; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, A A; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, Aldo L; Phillips, T J; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P B; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, W K; Salamanna, G; Salto, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savard, P; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, E E; Schmidt, M A; Schmidt, M P; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, A L; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyrla, A; Shalhout, S Z; Shapiro, M D; Shears, T G; Shepard, P F; Sherman, D; Shimojima, M; Shochet, M; Shon, Y; Shreyber, I; Sidoti, A; Sinervo, P; Sisakian, A; Slaughter, A J; Slaunwhite, J; Sliwa, K; Smith, J R; Snider, F D; Snihur, R; Söderberg, M; Soha, A; Somalwar, S; Sorin, V; Spalding, J; Spinella, F; Spreitzer, T; Squillacioti, P; Stanitzki, M; Staveris-Polykalas, A; Saint-Denis, R; Stelzer, B; Stelzer-Chilton, O; Stentz, D; Strologas, J; Stuart, D; Suh, J S; Sukhanov, A; Sun, H; Suslov, I; Suzuki, T; Taffard, A; Takashima, R; Takeuchi, Y; Tanaka, R; Tecchio, M; Teng, P K; Terashi, K; Tesarek, R J; Thom, J; Thompson, A S; Thomson, E; Tipton, P; Tiwari, V; Tkaczyk, S; Toback, D; Tokar, S; Tollefson, K; Tomura, T; Tonelli, D; Torre, S; Torretta, D; Tourneur, S; Trischuk, W; Tsuno, S; Tu, Y; Turini, N; Ukegawa, F; Uozumi, S; Vallecorsa, S; Van Remortel, N; Varganov, A; Vataga, E; Vázquez, F; Velev, G; Vellidis, C; Veramendi, G; Veszpremi, V; Vidal, M; Vidal, R; Vila, I; Vilar, R; Vine, T; Vogel, M; Vollrath, I; Volobuev, I P; Volpi, G; Würthwein, F; Wagner, P; Wagner, R G; Wagner, R L; Wagner, J; Wagner, W; Wallny, R; Wang, S M; Warburton, A; Waters, D; Weinberger, M; Wester, W C; Whitehouse, B; Whiteson, D; Wicklund, A B; Wicklund, E; Williams, G; Williams, H H; Wilson, P; Winer, B L; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, S M; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, U K; Yang, Y C; Yao, W M; Yeh, G P; Yoh, J; Yorita, K; Yoshida, T; Yu, G B; Yu, I; Yu, S S; Yun, J C; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zhou, J; Zucchelli, S

    2007-01-01

    We report an observation of new bottom baryons produced in proton-antiproton collisions at the Tevatron. Using 1.1 fb^{-1} of data collected by the CDF II detector, we observe four \\Lambda_b^0\\pi^{\\pm} resonances in the fully reconstructed decay mode \\Lambda_b^0 \\to \\Lambda_c^+ \\pi^-, where \\Lambda_c^+ \\to p K^- \\pi^+. We interpret these states as the \\Sigma_b^{(*)\\pm} baryons and measure their masses to be: m_{\\Sigma_b^+} = 5807.8^{+2.0}_{-2.2} (stat.) \\pm 1.7 (syst.) MeV/c^2 m_{\\Sigma_b^-} = 5815.2 \\pm 1.0 (stat.) \\pm 1.7 (syst.) MeV/c^2 m_{\\Sigma_b^{*+}} = 5829.0^{+1.6}_{-1.8} (stat.) ^{+1.7}_{-1.8} (syst.) MeV/c^2 m_{\\Sigma_b^{*-}} = 5836.4 \\pm 2.0 (stat.) ^{+1.8}_{-1.7} (syst.) MeV/c^2

  2. Six sigma and lean production adoption in a manufacturing company

    Directory of Open Access Journals (Sweden)

    Alisson Christian Scheller

    2014-11-01

    Full Text Available The connection among Lean Production with Six Sigma originated the Lean Six Sigma methodology, focused on processes variation and waste reduction. This methodology was developed on different ways in the companies and there is no consensus over its structure and its implementation. In this context, this paper aims to identify and analyze the main characteristics on the adoption and integration of Lean Six Sigma methodology through a case study conducted in a manufacturing company that adopts lean production and six sigma. The results show two important aspects of the Lean Six Sigma methodology. One of them is the adoption of the value stream mapping as a central tool on Lean Six Sigma. The other is the use of DMAIC for improvements actions. The study indicates that despite the difficulties on Lean Six Sigma implementation, the methodology offers benefits to the company that adopts it in the suitable way.

  3. Six sigma: program characteristics in eleven companies located in the metropolitan region of Porto Alegre

    Directory of Open Access Journals (Sweden)

    Jaqueline Terezinha Martins Correa Rodrigues

    2012-01-01

    Full Text Available Six Sigma combines managerial factors with statistical tools and is deployed in many enterprises today. Rio Grande do Sul is a Brazilian state that has a great industrialization, especially in the metropolitan area of Porto Alegre. Some of these industries have deployed the Six Sigma program. The aim of this paper is to present characteristics of the Six Sigma program in companies located in this region, through an exploratory study. A literature review subsidized the development of the questionnaire. Eleven companies participated of research in July and August 2008. It used statistical tools and qualitative analysis to analyze the results. Most of the companies that participated is classified as large and uses the DMAIC method to implement Six Sigma. The principal cause of program implementation was process improvement. In only one company the Six Sigma is implemented in all sectors, including administrative areas. Another result is the lack of clearly criteria for defining the career of Belts and the discrepancy of academic formation of these specialists.

  4. Vector transition form factors of the $N K^*\\to\\Theta^+ $ and $N \\bar{K}^*\\to \\Sigma_{\\bar{10}}^{*-}$ in the SU(3) chiral quark-soliton model

    CERN Document Server

    Ledwig, Tim; Goeke, Klaus

    2008-01-01

    We investigate the vector transition form factors of the nucleon and vector meson $K^*$ to the pentaquark baryon $\\Theta^+$ within the framework of the SU(3) chiral quark-soliton model. We take into account the rotational $1/N_c$ and linear $m_{\\rm s}$ corrections, assuming isospin symmetry and employing the symmetry-conserving quantization. It turns out that the leading-order contributions to the form factors are almost cancelled by the rotational corrections. Because of this, the flavor SU(3) symmetry-breaking terms yield sizeable effects on the transition form factors. In particular, the main contribution to the electric transition form factor comes from the wave-function corrections, which is a consequence of the generalized Ademollo-Gatto theorem derived in the present work. We estimate with the help of the vector meson dominance the $K^*$ vector and tensor coupling constants for the $\\Theta^+$: $g_{K^{*}N\\Theta}=0.74 - 0.87$ and $f_{K^{*}N\\Theta}=0.53 - 1.16$. We argue that the outcome of the present wo...

  5. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation.

    Science.gov (United States)

    Wu, Zhuang; Li, Linlang; Zheng, Long-Tai; Xu, Zhihong; Guo, Lin; Zhen, Xuechu

    2015-09-01

    Recent studies have shown that sigma-1 receptor orthodox agonists can inhibit neuroinflammation. SKF83959 (3-methyl-6-chloro-7,8-hydroxy-1-[3-methylphenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine), an atypical dopamine receptor-1 agonist, has been recently identified as a potent allosteric modulator of sigma-1 receptor. Here, we investigated the anti-inflammatory effects of SKF83959 in lipopolysaccharide (LPS)-stimulated BV2 microglia. Our results indicated that SKF83959 significantly suppressed the expression/release of the pro-inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and inhibited the generation of reactive oxygen species. All of these responses were blocked by selective sigma-1 receptor antagonists (BD1047 or BD1063) and by ketoconazole (an inhibitor of enzyme cytochrome c17 to inhibit the synthesis of endogenous dehydroepiandrosterone, DHEA). Additionally, we found that SKF83959 promoted the binding activity of DHEA with sigma-1 receptors, and enhanced the inhibitory effects of DHEA on LPS-induced microglia activation in a synergic manner. Furthermore, in a microglia-conditioned media system, SKF83959 inhibited the cytotoxicity of conditioned medium generated by LPS-activated microglia toward HT-22 neuroblastoma cells. Taken together, our study provides the first evidence that allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Our results indicated that SKF83959 enhanced the activity of endogenous dehydroepiandrosterone (DHEA) in a synergic manner, and inhibited the activation of BV2 microglia and the expression/release of the pro-inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS).

  6. The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation.

    Science.gov (United States)

    Hastie, Jessica L; Williams, Kyle B; Bohr, Lindsey L; Houtman, Jon C; Gakhar, Lokesh; Ellermeier, Craig D

    2016-09-01

    σ factors provide RNA polymerase with promoter specificity in bacteria. Some σ factors require activation in order to interact with RNA polymerase and transcribe target genes. The Extra-Cytoplasmic Function (ECF) σ factor, σV, is encoded by several Gram-positive bacteria and is specifically activated by lysozyme. This activation requires the proteolytic destruction of the anti-σ factor RsiV via a process of regulated intramembrane proteolysis (RIP). In many cases proteases that cleave at site-1 are thought to directly sense a signal and initiate the RIP process. We previously suggested binding of lysozyme to RsiV initiated the proteolytic destruction of RsiV and activation of σV. Here we determined the X-ray crystal structure of the RsiV-lysozyme complex at 2.3 Å which revealed that RsiV and lysozyme make extensive contacts. We constructed RsiV mutants with altered abilities to bind lysozyme. We find that mutants that are unable to bind lysozyme block site-1 cleavage of RsiV and σV activation in response to lysozyme. Taken together these data demonstrate that RsiV is a receptor for lysozyme and binding of RsiV to lysozyme is required for σV activation. In addition, the co-structure revealed that RsiV binds to the lysozyme active site pocket. We provide evidence that in addition to acting as a sensor for the presence of lysozyme, RsiV also inhibits lysozyme activity. Thus we have demonstrated that RsiV is a protein with multiple functions. RsiV inhibits σV activity in the absence of lysozyme, RsiV binds lysozyme triggering σV activation and RsiV inhibits the enzymatic activity of lysozyme. PMID:27602573

  7. Role of Burkholderia pseudomallei Sigma N2 in Amino Acids Utilization and in Regulation of Catalase E Expression at the Transcriptional Level

    Directory of Open Access Journals (Sweden)

    Duong Thi Hong Diep

    2015-01-01

    Full Text Available Burkholderia pseudomallei is the causative agent of melioidosis. The complete genome sequences of this pathogen have been revealed, which explain some pathogenic mechanisms. In various hostile conditions, for example, during nitrogen and amino acid starvation, bacteria can utilize alternative sigma factors such as RpoS and RpoN to modulate genes expression for their adaptation and survival. In this study, we demonstrate that mutagenesis of rpoN2, which lies on chromosome 2 of B. pseudomallei and encodes a homologue of the sigma factor RpoN, did not alter nitrogen and amino acid utilization of the bacterium. However, introduction of B. pseudomallei rpoN2 into E. coli strain deficient for rpoN restored the ability to utilize amino acids. Moreover, comparative partial proteomic analysis of the B. pseudomallei wild type and its rpoN2 isogenic mutant was performed to elucidate its amino acids utilization property which was comparable to its function found in the complementation assay. By contrast, the rpoN2 mutant exhibited decreased katE expression at the transcriptional and translational levels. Our finding indicates that B. pseudomallei RpoN2 is involved in a specific function in the regulation of catalase E expression.

  8. An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model

    Science.gov (United States)

    McCrae, Robert R.; Scally, Matthew; Terracciano, Antonio; Abecasis, Gonçalo R.; Costa, Paul T.

    2011-01-01

    There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely-unsuccessful search for individual polymorphisms associated with personality traits, we identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two-thirds of a large (N = 3,972) sample of individuals from Sardinia who completed the Revised NEO Personality Inventory and were assessed in a genome-wide association scan. When MPSs were correlated with the phenotype in the remaining third of the sample, very small but significant associations were found for four of the five personality factors when the longest scales were examined. These data suggest that MPSs for Neuroticism, Openness to Experience, Agreeableness, and Conscientiousness (but not Extraversion) contain genetic information that can be refined in future studies, and the procedures described here should be applicable to other quantitative traits. PMID:21114353

  9. An alternative to the search for single polymorphisms: toward molecular personality scales for the five-factor model.

    Science.gov (United States)

    McCrae, Robert R; Scally, Matthew; Terracciano, Antonio; Abecasis, Gonçalo R; Costa, Paul T

    2010-12-01

    There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two thirds of a large (N = 3,972) sample of individuals from Sardinia who completed the Revised NEO Personality Inventory (P. T. Costa, Jr., & R. R. McCrae, 1992) and were assessed in a genomewide association scan. When MPSs were correlated with the phenotype in the remaining one third of the sample, very small but significant associations were found for 4 of the 5e personality factors when the longest scales were examined. These data suggest that MPSs for Neuroticism, Openness to Experience, Agreeableness, and Conscientiousness (but not Extraversion) contain genetic information that can be refined in future studies, and the procedures described here should be applicable to other quantitative traits. PMID:21114353

  10. Explicit BCJ numerators of nonlinear sigma model

    CERN Document Server

    Du, Yi-Jian

    2016-01-01

    In this paper, we investigate the color-kinematics duality in nonlinear sigma model (NLSM). We present explicit polynomial expressions for the kinematic numerators (BCJ numerators). The calculation is done separately in two parametrization schemes of the theory using Kawai-Lewellen-Tye relation inspired technique, both lead to polynomial numerators. We summarize the calculation in each case into a set of rules that generates BCJ numerators for all multilplicities. In Cayley parametrization we find the numerator is described by a particularly simple formula solely in terms of momentum kernel.

  11. Lean Six Sigma Projects and IT

    Institute of Scientific and Technical Information of China (English)

    Gyula Mosoni; Chee-Cheng Chen

    2013-01-01

    Lean Six Sigma operations capitalizing on the benefits of using IT follow the same principle as other process improvement methods where the main goals are maximizing the value, eliminating waste, and minimizing defects. If the transformation has been planned in the appropriate way, customer satisfaction should become higher (e.g., easier to use the web site, safer payment process, shorter waiting time)and the operations will generally be smoother; as a result, the company should be on track to becoming more profitable.

  12. QCD strings as constrained grassmannian sigma model

    CERN Document Server

    Viswanathan, K S; Viswanathan, K S; Parthasarathy, R

    1995-01-01

    We present calculations for the effective action of string world sheet in R3 and R4 utilizing its correspondence with the constrained Grassmannian sigma model. Minimal surfaces describe the dynamics of open strings while harmonic surfaces describe that of closed strings. The one-loop effective action for these are calculated with instanton and anti-instanton background, reprsenting N-string interactions at the tree level. The effective action is found to be the partition function of a classical modified Coulomb gas in the confining phase, with a dynamically generated mass gap.

  13. String Field Equations from Generalized Sigma Model

    Energy Technology Data Exchange (ETDEWEB)

    Bardakci, K.; Bernardo, L.M.

    1997-01-29

    We propose a new approach for deriving the string field equations from a general sigma model on the world-sheet. This approach leads to an equation which combines some of the attractive features of both the renormalization group method and the covariant beta function treatment of the massless excitations. It has the advantage of being covariant under a very general set of both local and non-local transformations in the field space. We apply it to the tachyon, massless and first massive level, and show that the resulting field equations reproduce the correct spectrum of a left-right symmetric closed bosonic string.

  14. F-theory and linear sigma models

    CERN Document Server

    Bershadsky, M; Greene, Brian R; Johansen, A; Lazaroiu, C I

    1998-01-01

    We present an explicit method for translating between the linear sigma model and the spectral cover description of SU(r) stable bundles over an elliptically fibered Calabi-Yau manifold. We use this to investigate the 4-dimensional duality between (0,2) heterotic and F-theory compactifications. We indirectly find that much interesting heterotic information must be contained in the `spectral bundle' and in its dual description as a gauge theory on multiple F-theory 7-branes. A by-product of these efforts is a method for analyzing semistability and the splitting type of vector bundles over an elliptic curve given as the sheaf cohomology of a monad.

  15. Different intracellular distribution of avian reovirus core protein sigmaA in cells of avian and mammalian origin

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez-Iglesias, Lorena; Lostale-Seijo, Irene; Martinez-Costas, Jose [Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, y Centro Singular de Investigacion en Quimica Biologica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, 15782-Santiago de Compostela (Spain); Benavente, Javier, E-mail: franciscojavier.benavente@usc.es [Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, y Centro Singular de Investigacion en Quimica Biologica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, 15782-Santiago de Compostela (Spain)

    2012-10-25

    A comparative analysis of the intracellular distribution of avian reovirus (ARV) core protein sigmaA in cells of avian and mammalian origin revealed that, whereas the viral protein accumulates in the cytoplasm and nucleolus of avian cells, most sigmaA concentrates in the nucleoplasm of mammalian cells in tight association with the insoluble nuclear matrix fraction. Our results further showed that sigmaA becomes arrested in the nucleoplasm of mammalian cells via association with mammalian cell-specific factors and that this association prevents nucleolar targeting. Inhibition of RNA polymerase II activity, but not of RNA polymerase I activity, in infected mammalian cells induces nucleus-to-cytoplasm sigmaA translocation through a CRM1- and RanGTP-dependent mechanism, yet a heterokaryon assay suggests that sigmaA does not shuttle between the nucleus and cytoplasm. The scarcity of sigmaA in cytoplasmic viral factories of infected mammalian cells could be one of the factors contributing to limited ARV replication in mammalian cells.

  16. FORMATION OF SIX SIGMA INFRASTRUCTURE FOR THE CORONARY STENTING PROCESS

    Directory of Open Access Journals (Sweden)

    Mehmet Tolga Taner

    2013-10-01

    Full Text Available The purpose of this study is to show how a tertiary care center in Turkey operating mainly in cardiology initiated Six Sigma principles to reduce the number of complications occuring during coronary stent insertion process. A Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC model for coronary stent insertion is suggested. Data were collected for 24-months. Twenty-two Critical-to-Quality (CTQ factors were identified for successful coronary stent insertion. The most frequent causes of complications in the process were found to be patients with previous bypass surgery or PCI, inexperience of staff members, highly damaged vessel structure, thin and/or long vessel diameter, inappropriate selection of stent type, inappropriate selection of balloon type and poor image quality.

  17. Ionic rotational branching ratios in resonant enhanced multiphoton ionization of NO via the A2Sigma(+)(3s sigma) and D2Sigma(+)(3p sigma) states

    Science.gov (United States)

    Rudolph, H.; McKoy, V.; Dixit, S. N.; Huo, W. M.

    1988-01-01

    Results are presented for the rotationally resolved photoelectron spectra resulting from a (2 + 1) one-color resonant enhanced multiphoton ionization (REMPI) of NO via the rotationally clean S21(11.5) and mixed S11(15.5) + R21(15.5) branches of the 0-0 transition in the D-X band. The calculations were done in the fixed-nuclei frozen core approximation. The resulting photoionization spectra, convoluted with a Lorentzian detection function, agree qualitatively with experimental results of Viswanathan et al. (1986) and support their conclusion that the nonspherical nature of the molecular potential creates a substantial l-mixing in the continuum, which in turn leads to the intense Delta N = 0 peak. The rather strong photoelectron energy dependence of the rotational branching ratios of the D 2Sigma(+) S21(11.5) line was investigated and compared to the weak energy dependence of the A 2Sigma(+) R22(21.5) line.

  18. Differential Poisson Sigma Models with Extended Supersymmetry

    CERN Document Server

    Arias, Cesar; Torres-Gomez, Alexander

    2016-01-01

    The induced two-dimensional topological N=1 supersymmetric sigma model on a differential Poisson manifold M presented in arXiv:1503.05625 is shown to be a special case of the induced Poisson sigma model on the bi-graded supermanifold T[0,1]M. The bi-degree comprises the standard N-valued target space degree, corresponding to the form degree on the worldsheet, and an additional Z-valued fermion number, corresponding to the degree in the differential graded algebra of forms on M. The N=1 supersymmetry stems from the compatibility between the (extended) differential Poisson bracket and the de Rham differential on M. The latter is mapped to a nilpotent vector field Q of bi-degree (0,1) on T*[1,0](T[0,1]M), and the covariant Hamiltonian action is Q-exact. New extended supersymmetries arise as inner derivatives along special bosonic Killing vectors on M that induce Killing supervector fields of bi-degree (0,-1) on T*[1,0](T[0,1]M).

  19. Six Sigma process improvements in automotive parts production

    OpenAIRE

    Soković, M.; D. Pavletić; E. Krulčić

    2006-01-01

    Purpose: of this paper: In the paper is presented a Six Sigma project, undertaken within company for production automotive parts, which deals with identification and reduction of production cost in the deburring process for gravity die-castings and improvement of quality level of produced parts.Design/methodology/approach: The objectives are achieved by application of Six Sigma approach to quality improvement project in automotive industry. The applied Six Sigma approach includes team works t...

  20. Six Sigma, absorptive capacity and organizational learning orientation

    OpenAIRE

    Guti??rrez-Guti??rrez, Leopoldo; Bustinza S??nchez, ??scar Fernando; Barrales-Molina, Vanesa

    2011-01-01

    Abstract The importance of the Six Sigma methodology in industry is growing constantly. However, there are few empirical studies that analyze the advantages of this methodology and its positive effects on organizational performance. The purpose of this paper is to extend understanding of the success of Six Sigma quality management initiatives by investigating the effects of Six Sigma teamwork and process management on absorptive capacity. It also seeks to understand the relation be...

  1. Quality and Competitiveness: A Lean Six Sigma Approach

    OpenAIRE

    Irina-Virginia Drăgulănescu; Delia Popescu

    2015-01-01

    Originally developed to improve the quality and production efficiency, Lean Six Sigma is now widely adopted in other non-manufacturing sectors such as financial, trade, services, etc. The methodology known as Lean Six Sigma combines the Six Sigma techniques, ‒ which allow companies to reduce manufacturing defects ‒ and the Lean Manufacturing principles, ‒ which help companies benefit from faster processing for lower costs and with superior quality. As a result of the research, the authors obs...

  2. Sigma A recognition sites in the Bacillus subtilis genome

    DEFF Research Database (Denmark)

    Jarmer, Hanne Østergaard; Larsen, Thomas Schou; Krogh, Anders Stærmose;

    2001-01-01

    A hidden Markov model of sigma (A) RNA polymerase cofactor recognition sites in Bacillus subtilis, containing either the common or the extended -10 motifs, has been constructed based on experimentally verified sigma (A) recognition sites. This work suggests that more information exists at the ini......A hidden Markov model of sigma (A) RNA polymerase cofactor recognition sites in Bacillus subtilis, containing either the common or the extended -10 motifs, has been constructed based on experimentally verified sigma (A) recognition sites. This work suggests that more information exists...

  3. Mucosal vaccination by adenoviruses displaying reovirus sigma 1

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, Eric A. [Department of Internal Medicine, Division of Infectious Diseases, Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, MN 55902 (United States); Camacho, Zenaido T. [Department of Cell Biology, Department of Natural Sciences, Western New Mexico University, Silver City, NM 88062 (United States); Hillestad, Matthew L. [Nephrology Training Program, Mayo Clinic, Rochester, MN 55902 (United States); Crosby, Catherine M.; Turner, Mallory A.; Guenzel, Adam J.; Fadel, Hind J. [Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, MN 55902 (United States); Mercier, George T. [Department of Physics, University of Houston, Houston, TX 77004 (United States); Barry, Michael A., E-mail: mab@mayo.edu [Department of Internal Medicine, Division of Infectious Diseases, Translational Immunovirology and Biodefense Program, Mayo Clinic, Rochester, MN 55902 (United States); Department of Immunology and Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55902 (United States)

    2015-08-15

    We developed adenovirus serotype 5 (Ad5) vectors displaying the sigma 1 protein from reovirus as mucosal vaccines. Ad5-sigma retargets to JAM-1 and sialic acid, but has 40-fold reduced gene delivery when compared to Ad5. While weaker at transduction, Ad5-sigma generates stronger T cell responses than Ad5 when used for mucosal immunization. In this work, new Ad5-fiber-sigma vectors were generated by varying the number of fiber β-spiral shaft repeats (R) between the fiber tail and sigma. Increasing chimera length led to decreasing insertion of these proteinsAd5 virions. Ad-R3 and R14 vectors effectively targeted JAM-1 in vitro while R20 did not. When wereused to immunize mice by the intranasal route, Ad5-R3-sigma produced higher serum and vaginal antibody responses than Ad5. These data suggest optimized Ad-sigma vectors may be useful vectors for mucosal vaccination. - Highlights: • Constructed adenoviruses (Ads) displaying different reovirus sigma 1 fusion proteins. • Progressively longer chimeras were more poorly encapsidated onto Ad virions. • Ad5-R3-sigma mediated better systemic and mucosal immune responses than Ad5.

  4. Summary talk at the conference on the $\\sigma$ resonance

    CERN Document Server

    Törnqvist, N A

    2000-01-01

    This report summarizes the most important results presented at the recent conference held at the Yukawa Institute of Theoretical Physics in Kyoto, devoted to the recently confirmed light sigma resonance. Remarkably, all speakers at this meeting took the light sigma for granted and many mass and width estimations near 500 MeV were presented. We emphasize that if the light and broad sigma is accepted as a true resonance it explains many basic problems of low energy hadronic physics in a simple way, especially if the linear sigma model is used as an approximate effective low energy theory.

  5. The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes

    OpenAIRE

    1994-01-01

    In this study, the structure of a novel 1.9-kb transcript coding for complement component 3 (C3) is described. This alternate C3 is identical to the 3' end of the C3 message beginning at position 3300 of the C3 cDNA. Its transcription appears to be driven by an alternate promoter located within intron 8 of the C3 gene. This alternate C3 message contains an open reading frame that may encode a 536-amino acid- long protein identical to the 3' part of the C3 alpha chain. The resulting protein co...

  6. Studies of $\\gamma\\gamma\\to\\Lambda\\bar{\\Lambda},\\Sigma^0\\bar{\\Sigma^0}$ production at Belle

    CERN Document Server

    Kuo, C C; Adachi, I; Aihara, H; Anipko, D; Aoki, K; Arakawa, T; Arinstein, K; Asano, Y; Aso, T; Aulchenko, V M; Aushev, T; Aziz, T; Bahinipati, S; Bakich, A M; Balagura, V; Ban, Y; Banerjee, S; Barberio, E; Barbero, M; Bay, A; Bedny, I; Belous, K S; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, M C; Chang, P; Chao, Y; Chen, A; Chen, K F; Chen, W T; Cheon, B G; Chistov, R; Choi, J H; Choi, S K; Choi, Y; Choi, Y K; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Dowd, R; Dragic, J; Drutskoy, A; Eidelman, S; Enari, Y; Epifanov, D A; Fratina, S; Fujii, H; Fujikawa, M; Gabyshev, N; Garmash, A; Gershon, T; Go, A; Gokhroo, G; Goldenzweig, P; Golob, B; Gorisek, A; Grosse-Perdekamp, M; Guler, H; Ha, H; Haba, J; Hara, K; Hara, T; Hasegawa, Y; Hastings, N C; Hayasaka, K; Hayashii, H; Hazumi, M; Heffernan, D; Higuchi, T; Hinz, L; Hokuue, T; Hoshi, Y; Hoshina, K; Hou, S; Hou, W S; Hsiung, Y B; Igarashi, Y; Iijima, T; Ikado, K; Imoto, A; Inami, K; Ishikawa, A; Ishino, H; Itoh, K; Itoh, R; Iwabuchi, M; Iwasaki, M; Iwasaki, Y; Jacoby, C; Jones, M; Kakuno, H; Kang, J H; Kang, J S; Kapusta, P; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kibayashi, A; Kichimi, H; Kikuchi, N; Kim, H J; Kim, H O; Kim, J H; Kim, S K; Kim, T H; Kim, Y J; Kinoshita, K; Kishimoto, N; Korpar, S; Kozakai, Y; Krizan, P; Krokovnyi, P P; Kubota, T; Kulasiri, R; Kumar, R; Kuo, C C; Kurihara, E; Kusaka, A; Kuzmin, A; Kwon, Y J; Lange, J S; Leder, G; Lee, J; Lee, S E; Lee, Y J; Lesiak, T; Li, J; Limosani, A; Lin, C Y; Lin, S W; Liu, Y; Liventsev, D; MacNaughton, J; Majumder, G; Mandl, F; Marlow, D; Matsumoto, T; Matyja, A; McOnie, S; Medvedeva, T; Mikami, Y; Mitaroff, W A; Miyabayashi, K; Miyake, H; Miyata, H; Miyazaki, Y; Mizuk, R; Mohapatra, D; Moloney, G R; Mori, T; Müller, J; Murakami, A; Nagamine, T; Nagasaka, Y; Nakagawa, T; Nakahama, Y; Nakamura, I; Nakano, E; Nakao, M; Nakazawa, H; Natkaniec, Z; Neichi, K; Nishida, S; Nishimura, K; Nitoh, O; Noguchi, S; Nozaki, T; Ogawa, A; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Ono, S; Ostrowicz, W; Ozaki, H; Pakhlov, P; Pakhlova, G; Palka, H; Park, C W; Park, H; Park, K S; Parslow, N; Peak, L S; Pernicka, M; Pestotnik, R; Peters, M; Piilonen, L E; Poluektov, A; Ronga, F J; Root, N; Rorie, J; Rózanska, M; Sahoo, H; Saitoh, S; Sakai, Y; Sakamoto, H; Sakaue, H; Sarangi, T R; Sato, N; Satoyama, N; Sayeed, K; Schietinger, T; Schneider, O; Schonmeier, P; Schümann, J; Schwanda, C; Schwartz, A J; Seidl, R; Seki, T; Senyo, K; Sevior, M E; Shapkin, M; Shen, Y T; Shibuya, H; Shwartz, B; Sidorov, V; Singh, J B; Sokolov, A; Somov, A; Soni, N; Stamen, R; Stanic, S; Staric, M; Stöck, H; Sugiyama, A; Sumisawa, K; Sumiyoshi, T; Suzuki, S; Suzuki, S Y; Tajima, O; Takada, N; Takasaki, F; Tamai, K; Tamura, N; Tanabe, K; Tanaka, M; Taylor, G N; Teramoto, Y; Tian, X C; Tikhomirov, I; Trabelsi, K; Tsai, Y T; Tse, Y F; Tsuboyama, T; Tsukamoto, T; Uchida, K; Uchida, Y; Uehara, S; Uglov, T; Ueno, K; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Yu; Varner, G; Varvell, K E; Villa, S; Wang, C C; Wang, C H; Wang, M Z; Watanabe, M; Watanabe, Y; Wicht, J; Widhalm, L; Wiechczynski, J; Won, E; Wu, C H; Xie, Q L; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamamoto, S; Yamashita, Y; Yamauchi, M; Heyoung Yang; Yoshino, S; Yuan, Y; Yusa, Y; Zang, S L; Zhang, C C; Zhang, J; Zhang, L M; Zhang, Z P; Zhilich, V; Ziegler, T; Zupanc, A; Zürcher, D; al., et

    2006-01-01

    Cross sections for hyperon pair production from two-photon collisions, $\\gamma\\gamma\\to\\Lambda\\bar{\\Lambda},\\Sigma^0\\bar{\\Sigma^0}$, are measured in the 2-4 GeV energy region at Belle, using 464 fb$^{-1}$ of data. A contribution from the intermediate resonance $\\eta_c(1S)$ is observed, and the products of the two-photon width of the $\\eta_c(1S)$ and its branching ratios to $\\Lambda\\bar{\\Lambda}$ and $\\Sigma^0\\bar{\\Sigma^0}$ are measured. The results will help test QCD models.

  7. First Observation of the $\\Sigma_{c}^{*+}$ Baryon and a New Measurement of the $\\Sigma_{c}^{+}$ Mass

    CERN Document Server

    Ammar, R; Besson, D; Davis, R; Kwak, N; Zhao, X; Anderson, S; Frolov, V V; Kubota, Y; Lee, S J; Mahapatra, R; O'Neill, J J; Poling, R A; Riehle, T; Smith, A; Stepaniak, C J; Urheim, J; Ahmed, S; Alam, M S; Athar, S B; Jian, L; Ling, L; Saleem, M; Timm, S; Wappler, F; Anastassov, A; Duboscq, J E; Eckhart, E; Gan, K K; Gwon, C; Hart, T; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pedlar, T K; Schwarthoff, H; Thayer, J B; Von Törne, E; Zoeller, M M; Richichi, S J; Severini, H; Skubic, P L; Undrus, A; Chen, S; Fast, J; Hinson, J W; Lee, J; Miller, D H; Shibata, E I; Shipsey, I P J; Pavlunin, V; Cronin-Hennessy, D; Lyon, A L; Thorndike, E H; Jessop, C P; Marsiske, H; Perl, Martin Lewis; Savinov, V; Zhou, X; Coan, T E; Fadeev, V; Maravin, Y; Narsky, I; Stroynowski, R; Ye, J; Wlodek, T; Artuso, M; Ayad, R; Boulahouache, C; Bukin, K; Dambasuren, E; Karamov, S; Majumder, G; Moneti, G C; Mountain, R; Schuh, S; Skwarnicki, T; Stone, S; Viehhauser, G; Wang, J C; Wolf, A; Wu, J; Kopp, S E; Mahmood, A H; Csorna, S E; Danko, I; McLean, K W; Marka, S; Xu, Z; Godang, R; Kinoshita, K; Lai, I C; Schrenk, S; Bonvicini, G; Cinabro, D; McGee, S; Perera, L P; Zhou, G J; Lipeles, E; Pappas, S P; Schmidtler, M; Shapiro, A; Sun, W M; Weinstein, A J; Würthwein, F; Jaffe, D E; Masek, G E; Paar, H P; Potter, E M; Prell, S; Sharma, V; Asner, D M; Eppich, A; Hill, T S; Morrison, R J; Briere, R A; Chen, G P; Behrens, B H; Ford, W T; Gritsan, A; Roy, J D; Smith, J G; Alexander, J P; Baker, R; Bebek, C; Berger, B E; Berkelman, K; Blanc, F; Boisvert, V; Cassel, David G; Dickson, M; Drell, P S; Ecklund, K M; Ehrlich, R; Foland, A D; Gaidarev, P B; Galik, R S; Gibbons, L K; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hopman, P I; Jones, C D; Kreinick, D L; Lohner, M; Magerkurth, A; Meyer, T O; Mistry, N B; Nordberg, E; Patterson, J R; Peterson, D; Riley, D; Thayer, J G; Urner, D; Valant-Spaight, B L; Warburton, A; Avery, P; Prescott, C; Rubiera, A I; Yelton, J; Zheng, J; Brandenburg, G; Ershov, A; Gao, Y S; Kim, D Y J; Wilson, R; Browder, T E; Li, Y; Rodríguez, J L; Yamamoto, H; Bergfeld, T; Eisenstein, B I; Ernst, J; Gladding, G E; Gollin, G D; Hans, R M; Johnson, E; Karliner, I; Marsh, M A; Palmer, M; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Janicek, R; Patel, P M; Sadoff, A J

    2001-01-01

    Using data recorded with the CLEO II and CLEO II.V detector configurations at the Cornell Electron Storage Rings, we report the first observation and mass measurement of the $\\Sigma_c^{*+}$ charmed baryon, and an updated measurement of the mass of the $\\Sigma_c^+$ baryon. We find $M(\\Sigma_c^{*+})-M(\\Lambda_c^+)$= 231.0 +- 1.1 +- 2.0 MeV, and $M(\\Sigma_c^{+})-M(\\Lambda_c^+)$= 166.4 +- 0.2 +- 0.3 MeV, where the errors are statistical and systematic respectively.

  8. Efficacy of fuzzy MADM approach in Six Sigma analysis phase in automotive sector

    Science.gov (United States)

    Rathi, Rajeev; Khanduja, Dinesh; Sharma, S. K.

    2016-02-01

    Six Sigma is a strategy for achieving process improvement and operational excellence within an organization. Decisions on critical parameter selection in analysis phase are always very crucial; it plays a primary role in successful execution of Six Sigma project and for productivity improvement in manufacturing environment and involves the imprecise, vague and uncertain information. Using a case study approach; the paper demonstrates a tactical approach for selection of critical factors of machine breakdown in center less grinding (CLG) section at an automotive industry using fuzzy logic based multi attribute decision making approach. In this context, we have considered six crucial attributes for selection of critical factors for breakdown. Mean time between failure is found to be the pivotal selection criterion in CLG section. Having calculated the weights pertinent to criteria through two methods (fuzzy VIKOR and fuzzy TOPSIS) critical factors for breakdown are prioritized. Our results are in strong agreement with the perceptions of production and maintenance department of the company.

  9. Characterization of pulmonary sigma receptors by radioligand binding.

    Science.gov (United States)

    Lever, John R; Litton, Tyler P; Fergason-Cantrell, Emily A

    2015-09-01

    This study establishes the expression of appreciable populations of sites on mouse lung membranes that exhibit radioligand binding properties and pharmacology consistent with assignment as sigma1 and sigma2 receptors. Specific binding of the sigma1 receptor radioligand [(3)H](+)-pentazocine reached steady state within 6h at 37°C. Saturation studies revealed high affinity binding to a single class of sites (Kd 1.36±0.04nM; Bmax 967±11fmol/mg protein). Inhibition studies showed appropriate sigma1 receptor pharmacology, including higher affinity for (+)-N-allylnormetazocine with respect to the (-)-enantiomer, and positive allosteric modulation of dextromethorphan binding by phenytoin. Using [(3)H]1,3-di(2-tolyl)guanidine in the presence of (+)-pentazocine to assess sigma2 receptor binding, steady state was achieved within 2min at 25°C. Cold saturation studies revealed one high affinity, low capacity binding site (Kd 31.8±8.3nM; Bmax 921±228fmol/mg protein) that displayed sigma2 receptor pharmacology. A very low affinity, high capacity interaction also was observed that represents saturable, but not sigma receptor specific, binding. A panel of ligands showed rank order inhibition of radioligand binding appropriate for the sigma2 receptor, with ifenprodil displaying the highest apparent affinity. In vivo, dextromethorphan inhibited the specific binding of a radioiodinated sigma1 receptor ligand in lung with an ED50 of 1.2μmol/kg, a value near the recommended dosage for the drug as a cough suppressant. Overall, the present work provides a foundation for studies of drug interactions with pulmonary sigma1 and sigma2 receptors in vitro and in vivo. PMID:26004528

  10. QCD monopole and sigma meson coupling

    CERN Document Server

    Iwazaki, Aiichi

    2016-01-01

    Under the assumption of the Abelian dominance in QCD, we show that chiral condensate is locally present around a QCD monopole. The appearance of the chiral condensate around a GUT monopole was shown in the previous analysis of the Rubakov effect. We apply a similar analysis to the QCD monopole. It follows that the condensation of the monopole carrying the chiral condensate leads to the chiral symmetry breaking as well as quark confinement. To realize the result explicitly, we present a phenomenological linear sigma model coupled with the monopoles, in which the monopole condensation causes the chiral symmetry breaking as well as confinement. The monopoles are assumed to be described by a model of dual superconductor. We identify the monopoles with scalar isoscalar $f_0$ mesons with masses $1400\\sim 1700$ MeV as well as dual gauge fields with $h_1$ vector mesons with masses $\\sim 1500$MeV.

  11. Dirichlet sigma models and mean curvature flow

    CERN Document Server

    Bakas, I

    2007-01-01

    The mean curvature flow describes the parabolic deformation of embedded branes in Riemannian geometry driven by their extrinsic mean curvature vector, which is typically associated to surface tension forces. It is the gradient flow of the area functional, and, as such, it is naturally identified with the boundary renormalization group equation of Dirichlet sigma models away from conformality, to lowest order in perturbation theory. D-branes appear as fixed points of this flow having conformally invariant boundary conditions. Simple running solutions include the paper-clip and the hair-pin (or grim-reaper) models on the plane, as well as scaling solutions associated to rational (p, q) closed curves and the decay of two intersecting lines. Stability analysis is performed in several cases while searching for transitions among different brane configurations. The combination of Ricci with the mean curvature flow is examined in detail together with several explicit examples of deforming curves on curved backgrounds...

  12. Polarimetric observations of $\\sigma$ Orionis E

    CERN Document Server

    Carciofi, Alex C; Townsend, Richard H D; Bjorkman, Jon E

    2013-01-01

    Some massive stars possess strong magnetic fields that confine plasma in the circumstellar environment. These \\textit{magnetospheres} have been studied spectroscopically, photometrically and, more recently, interferometrically. Here we report on the first firm detection of a magnetosphere in continuum linear polarization, as a result of monitoring of $\\sigma$\\,Ori\\,E at the Pico dos Dias Observatory. {The non-zero intrinsic polarization indicates an asymmetric structure, whose minor elongation axis is oriented $150\\fdg0$ east of the celestial north.} A modulation of the polarization was observed, with a period of half of the rotation period, which supports the theoretical prediction of the presence of two diametrally opposed, co-rotating blobs of gas. A phase lag of -0.085 was detected between the polarization minimum and the primary minimum of the light curve, suggestive of a complex shape of the plasma clouds. We present a preliminary analysis of the data with the Rigidly Rotating Magnetosphere model, which...

  13. Environmental Data Flow Six Sigma Process Improvement Savings Overview

    Energy Technology Data Exchange (ETDEWEB)

    Paige, Karen S [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-05-20

    An overview of the Environmental Data Flow Six Sigma improvement project covers LANL’s environmental data processing following receipt from the analytical laboratories. The Six Sigma project identified thirty-three process improvements, many of which focused on cutting costs or reducing the time it took to deliver data to clients.

  14. Inspanning om Lean Six Sigma op kaart te zetten beloond

    NARCIS (Netherlands)

    R.J.M.M. Does

    2008-01-01

    Prof.dr. R.J.M.M. Does is al jarenlang een fervent voorvechter voor het gebruik van statistiek. En meer recent is hij zo’n beetje de belichaming van (Lean) Six Sigma in Europa. Tal van grote organisaties hebben hem te hulp geroepen bij de invoering van (Lean) Six Sigma. Het is dan ook niet meer dan

  15. Lean Six Sigma in het ziekenhuis: De beschikbaarheid van infuuspompen

    NARCIS (Netherlands)

    R.J.M.M. Does; B.P.H. Kemper; M. Koopmans

    2011-01-01

    In het topklinisch ziekenhuis Medisch Spectrum Twente werd in 2008 een Lean Six Sigma-project gestart. Het doel was vermindering van operationele kosten van infuuspompen. Het is een interessant voorbeeld van Lean Six Sigma in de gezondheidszorg, omdat het laat zien dat kostenbesparing niet hoeft te

  16. Kaluza-Klein Monopoles and Gauged Sigma Models

    NARCIS (Netherlands)

    Bergshoeff, E.A.

    1998-01-01

    We review some aspects of branes. In particular, we discuss the worldvolume theory describing the dynamics of the Kaluza-Klein monopole which turns out to be a gauged sigma model. We also briefly review some recent applications of gauged sigma models to the worldvolume description of massive branes,

  17. Kaluza-Klein monopoles and gauged sigma-models

    NARCIS (Netherlands)

    Bergshoeff, E; Janssen, B; Ortin, T; Alvarez-Gaumé, L.

    1997-01-01

    We propose an effective action for the eleven-dimensional (bosonic) Kaluza-Klein monopole solution. The construction of the action requires that the background fields admit an Abelian isometry group. The corresponding sigma-model is gauged with respect to this isometry. The gauged sigma-model is the

  18. An application of Lean Six Sigma in a hospital

    NARCIS (Netherlands)

    J. van den Heuvel; R.J.M.M. Does; H. de Koning

    2007-01-01

    Abstract Healthcare today faces major challenges. Patients demand quality of care to be improved continuously. Insurance companies demand the lowest possible prices. Lean Six Sigma is a tool that can help healthcare providers to achieve these at least partly conflicting goals. Lean Six Sigma is an i

  19. Studi Implementasi Six Sigma dalam Sistem Inventori Galangan Kapal

    Directory of Open Access Journals (Sweden)

    Elwin Elwin

    2012-09-01

    Full Text Available Dalam industri galangan kapal terdapat bahan baku, barang dalam proses dan barang jadi yang merupakan macam-macam bentuk dari persediaan dan berhubungan dengan stok, ketika persediaan tidak dikelola dengan benar maka akan terjadi pembengkakkan biaya/pengeluaran biaya yang tidak dibutuhkan. Tugas akhir ini bertujuan untuk mengetahui kondisi inventori di PT. Dok dan Perkapalan Surbaya, untuk mengetahui faktor-faktor yang menjadi penyebab terjadinya variabilitas output six sigma dan mengurangi defect pada sistem inventori dengan menggunakan metode six sigma DMAIC (Define, Measure, Analyze, Improve dan Control,. Berdasarkan perhitungan Material Pipa mengalami defect sebesar 50.98% dengan nilai sigma 1.48, Material Elbow mengalami defect sebesar 89.80% dengan nilai sigma 0.33, Material Flange mengalami defect sebesar 71.99% dengan nilai sigma 0.90, Material Paking mengalami defect sebesar 13.12% dengan nilai sigma 2.74 dan Material Mur mengalami defect sebesar 17.26% dengan nilai sigma 2.57. Sesuai dengan perhitungan reorder point for the inventory untuk masing-masing material, maka dapat diketahui bahwa material Pipa reoder point adalah 58 lonjor, elbow 100 buah, flange 168 buah, paking 24 buah dan mur 946 buah. Nilai sigma yang diperoleh dalam perhitungan tingkat persediaan masih jauh dari nilai yang seharusnya dapat dicapai oleh suatu perusahaan (6σ, sehingga dilakukan tahap Improve dengan metode Failure Mode and Effect Analysis (FMEA, pembuat SOP Pengendalian persediaan material dengan format baru serta galangan perlu melakukan perhitungan reorder point.  

  20. The sigma(54) regulon (sigmulon) of Pseudomonas putida

    DEFF Research Database (Denmark)

    Cases, I.; Ussery, David; de Lorenzo, V.

    2003-01-01

    methods, the sigma(54) regulon has been studied both in Escherichia coli, Salmonella typhimurium and several species of the Rhizobiaceae. Here we present the analysis of the sigma(54) regulon (sigmulon) in the complete genome of Pseudomonas putida KT2440. We have developed an improved method for the...

  1. Application of Six Sigma Method to EMS Design

    Science.gov (United States)

    Rusko, Miroslav; Králiková, Ružena

    2011-01-01

    The Six Sigma method is a complex and flexible system of achieving, maintaining and maximizing the business success. Six Sigma is based mainly on understanding the customer needs and expectation, disciplined use of facts and statistics analysis, and responsible approach to managing, improving and establishing new business, manufacturing and service processes.

  2. Wess Zumino Couplings for Generalized $\\Sigma$ Orbifold Fixed-points

    CERN Document Server

    Ospina-Giraldo, J F

    2000-01-01

    The Wess-Zumino couplings for generalized sigma-orbifold fixed-points are presented and the generalized GS 6-form that encoding the complete sigma-standard gauge-gravitational-non standard gauge anomaly and its opposite inflow is derived.

  3. Developing an integrated model for evaluation and selection of six sigma projects using ANN

    Directory of Open Access Journals (Sweden)

    Seyed Habib Allah Mirghafoori

    2012-03-01

    Full Text Available Six Sigma is one of the most popular systems for eliminating waste, reducing cost and improving quality in organizations. The process of evaluation and selection of projects is the first step towards implementing Six Sigma and many researchers believe that these are important for the success of such projects. Respectively, in this paper, a model has been proposed based on artificial neural network (ANN as an effective tool for non-linear information processing . In this model, six criteria of project cost, project duration, number of Black and Green Belts, improving customer satisfaction, impact on business strategy and financial impact have been identified as input factors and productivity and sigma level of improvement projects have been estimated using multi-layer perception (MLP. Finally, sensitivity analysis has been used for evaluation of the influence of inputs on outputs. The findings imply that 'business strategy' and 'financial impact' have the most and the least influence on model's outputs, including productivity and Sigma level, respectively.     .

  4. [Improvement of medical processes with Six Sigma - practicable zero-defect quality in preparation for surgery].

    Science.gov (United States)

    Sobottka, Stephan B; Töpfer, Armin; Eberlein-Gonska, Maria; Schackert, Gabriele; Albrecht, D Michael

    2010-01-01

    Six Sigma is an innovative management- approach to reach practicable zero- defect quality in medical service processes. The Six Sigma principle utilizes strategies, which are based on quantitative measurements and which seek to optimize processes, limit deviations or dispersion from the target process. Hence, Six Sigma aims to eliminate errors or quality problems of all kinds. A pilot project to optimize the preparation for neurosurgery could now show that the Six Sigma method enhanced patient safety in medical care, while at the same time disturbances in the hospital processes and failure costs could be avoided. All six defined safety relevant quality indicators were significantly improved by changes in the workflow by using a standardized process- and patient- oriented approach. Certain defined quality standards such as a 100% complete surgical preparation at start of surgery and the required initial contact of the surgeon with the patient/ surgical record on the eve of surgery could be fulfilled within the range of practical zero- defect quality. Likewise, the degree of completion of the surgical record by 4 p.m. on the eve of surgery and their quality could be improved by a factor of 170 and 16, respectively, at sigma values of 4.43 and 4.38. The other two safety quality indicators "non-communicated changes in the OR- schedule" and the "completeness of the OR- schedule by 12:30 a.m. on the day before surgery" also show an impressive improvement by a factor of 2.8 and 7.7, respectively, corresponding with sigma values of 3.34 and 3.51. The results of this pilot project demonstrate that the Six Sigma method is eminently suitable for improving quality of medical processes. In our experience this methodology is suitable, even for complex clinical processes with a variety of stakeholders. In particular, in processes in which patient safety plays a key role, the objective of achieving a zero- defect quality is reasonable and should definitely be aspirated. PMID

  5. Optimizing The DSSC Fabrication Process Using Lean Six Sigma

    Science.gov (United States)

    Fauss, Brian

    Alternative energy technologies must become more cost effective to achieve grid parity with fossil fuels. Dye sensitized solar cells (DSSCs) are an innovative third generation photovoltaic technology, which is demonstrating tremendous potential to become a revolutionary technology due to recent breakthroughs in cost of fabrication. The study here focused on quality improvement measures undertaken to improve fabrication of DSSCs and enhance process efficiency and effectiveness. Several quality improvement methods were implemented to optimize the seven step individual DSSC fabrication processes. Lean Manufacturing's 5S method successfully increased efficiency in all of the processes. Six Sigma's DMAIC methodology was used to identify and eliminate each of the root causes of defects in the critical titanium dioxide deposition process. These optimizations resulted with the following significant improvements in the production process: 1. fabrication time of the DSSCs was reduced by 54 %; 2. fabrication procedures were improved to the extent that all critical defects in the process were eliminated; 3. the quantity of functioning DSSCs fabricated was increased from 17 % to 90 %.

  6. The LHCb pentaquark as a $\\bar{D}^*\\Sigma_c-\\bar{D}^*\\Sigma_c^*$ molecular state

    CERN Document Server

    Roca, L; Oset, E

    2015-01-01

    We perform a theoretical analysis of the $\\Lambda_b \\to J/\\psi K^- p$ reaction from where a recent LHCb experiment extracts a $\\Lambda(1405)$ contribution in the $K^- p$ spectrum close to threshold and two baryon states of hidden charm in the $J/\\psi\\,p$ spectrum. We recall that baryon states of this type have been theoretically predicted matching the mass, width and $J^P$ of the experiment, concretely some states built up from the $J/\\psi\\, N$, $\\bar D^* \\Lambda_c$, $\\bar D^* \\Sigma_c$, $\\bar D \\Sigma^*_c$ and $\\bar D^* \\Sigma^*_c$ coupled channels. We assume that the observed narrow state around 4450 MeV has this nature and we are able to describe simultaneously the shapes and relative strength of the the $K^- p$ mass distribution close to threshold and the peak of the $J/\\psi\\,p$ distribution, with values of the $J/\\psi\\, p$ coupling to the resonance in line with the theoretical ones. The non trivial matching of many properties gives support to a $J^P=3/2^-$ assignment to this state and to its nature as a ...

  7. Lean six sigma case studies in the healthcare enterprise

    CERN Document Server

    Furterer, Sandra L

    2014-01-01

    This book provides a detailed description of how to apply Lean Six Sigma in the health care industry, with a special emphasis on process improvement and operations management in hospitals.  The book begins with a description of the Enterprise Performance Excellence (EPE) improvement methodology developed by the author that links several methodologies including systems thinking, theory of constraints, Lean and Six Sigma to provide an enterprise-wide prioritization and value-chain view of health care. The EPE methodology helps to improve flow at the macro or value-chain level, and then identifies Lean Six Sigma detailed improvements that can further improve processes within the value-chain.  The book also provides real-world health care applications of the EPE and Lean Six Sigma methodologies that showed significant results on throughput, capacity, operational and financial performance. The Enterprise Performance Excellence methodology is described, and also the Six Sigma DMAIC (Define-Measure-Analyze-Improve...

  8. Sigma factors in a thousand E. coli genomes

    DEFF Research Database (Denmark)

    Cook, Helen Victoria; Ussery, David

    2013-01-01

    , we describe a method to quickly sort through genomes for a particular set of protein families. We apply these two methods to all of the current Escherichia coli genomes available in the The National Center for Biotechnology Information database. Out of the 2074 E. coli/Shigella genomes listed (June...

  9. Erratum to "Nuclear Effects on R=\\sigma_L\\/\\sigma_T in Deep-Inelastic Scattering", In

    CERN Document Server

    Airapetian, A

    2002-01-01

    This erratum revokes the main conclusion of a Letter that reported measurements of cross sections for deep-inelastic scattering (DIS) of leptons on $^3$He and $^{14}$N targets, expressed as ratios of $\\sigma_A / \\sigma_D$ to the cross section on the deuterium target.

  10. Rotationally resolved A(3)Sigma(-)(u)-X-3 Sigma(-)(g) spectrum of HC7H

    NARCIS (Netherlands)

    Wehres, N.; Zhao, D.; Ubachs, W.; Linnartz, H.

    2010-01-01

    The A(3)Sigma X--(u)3 Sigma(-)(g) electronic spectrum of the linear carbon chain radical HC7H has been recorded fully rotationally resolved. Cavity ring-down spectroscopy is used to record the origin band transition in direct absorption through a supersonically expanding planar plasma, discharging a

  11. The linear U3 x U3 sigma Model, the sigma resonance and the spontaneous breaking of symmetries

    CERN Document Server

    Törnqvist, N A

    1998-01-01

    My recent fit of the light scalar mesons is discussed in the light of the U3 x U3 linear sigma model. The argument for why there exists a light and broad sigma meson is explained in more detail, and the mechanism of spontaneous symmetry breaking is discussed.

  12. The $C \\: ^1 \\Sigma ^+$, $A \\: ^1 \\Sigma ^+$, and $b \\: ^3 \\Pi_{0^+}$ states of LiRb

    CERN Document Server

    Stevenson, I C; Chen, Y P; Elliott, D S

    2016-01-01

    We present the first spectroscopic studies of the $C \\ ^1\\Sigma^+$ electronic state and the $A \\ ^1\\Sigma^+$ - $b \\ ^3\\Pi_{0^+}$ complex in $^7$Li - $^{85}$Rb. Using resonantly-enhanced, two-photon ionization, we observed $v = 7$, 9, 12, 13 and $26-44$ of the $C \\ ^1\\Sigma^+$ state. We augment the REMPI data with a form of depletion spectra in regions of dense spectral lines. The $A \\ ^1\\Sigma^+$ - $b \\ ^3\\Pi_{0^+}$ complex was observed with depletion spectroscopy, depleting to vibrational levels $v=0 \\rightarrow 29$ of the $A \\ ^1\\Sigma^+$ state and $v=8 \\rightarrow 18$ of the $b \\ ^3\\Pi_{0^+}$ state. For all three series, we determine the term energy and vibrational constants. Finally, we outline several possible future projects based on the data presented here.

  13. Prospects for observing the lowest-lying odd-parity $\\Sigma_c$ and $\\Sigma_b$ baryons

    CERN Document Server

    Karliner, Marek

    2015-01-01

    There exist candidates for the negative-parity states $\\Lambda_{c,b}(1/2^-, 3/2^-)$ consisting of an isospin-zero, spin-zero light diquark $[ud]$ with one unit of orbital angular momentum with respect to a $c,b$ quark. However, there exists only one candidate for the orbital excitations of the $\\Sigma_c(1/2^+)$ and $\\Sigma_c^*(3/2^+)$, and none for the orbital excitations of $\\Sigma_b(1/2^+)$ or $\\Sigma_b^*(3/2^+)$. We extend a previous discussion of odd-parity $\\Lambda_{c,b}$ states and explore some patterns of the odd-parity $\\Sigma_{c,b}$ baryons consisting of a light isospin-one nonstrange diquark $(uu,ud,dd)$ in a state of $L=1$ with respect to the spin-1/2 heavy quark $(c,b)$.

  14. $\\Lambda_c\\Sigma_c\\pi$ coupling and $\\Sigma_c \\rightarrow\\Lambda_c \\pi$ decay in lattice QCD

    CERN Document Server

    Can, K U; Oka, M; Takahashi, T T

    2016-01-01

    We evaluate the $\\Lambda_c\\Sigma_c\\pi$ coupling constant ($G_{\\Lambda_c \\Sigma_c \\pi}$) and the width of the strong decay $\\Sigma_c \\rightarrow\\Lambda_c \\pi$ in 2+1 flavor lattice QCD on four different ensembles with pion masses ranging from 700 MeV to 300 MeV. We find $G_{\\Lambda_c \\Sigma_c \\pi}=18.332(1.476)_{\\rm{stat.}}(2.171)_{\\rm{syst.}}$ and the decay width $\\Gamma(\\Sigma_c \\rightarrow\\Lambda_c \\pi)=1.65(28)_{\\rm{stat.}}(30)_{\\rm{syst.}}$~MeV on the physical quark-mass point, which is in agreement with the recent experimental determination.

  15. MANAGING INNOVATION USING DESIGN FOR SIX SIGMA (DFSS) APPROACH IN HEALTHCARE SERVICE ORGANIZATIONS

    OpenAIRE

    YUDI AZIS; HIROSHI OSADA

    2013-01-01

    Nowadays, healthcare service organizations have been using Design for Six Sigma (DFSS) for managing innovation to create new products, services and business processes. This paper is intended to demonstrate the effectiveness of DFSS on managing innovation in healthcare service organizations. The research is conducted on five leading US healthcare service organizations. Furthermore, roadmap for managing innovation is proposed. The result confirms that the DFSS strengthens two factors in managin...

  16. An Application of Six Sigma to Reduce Supplier Quality Cost

    Science.gov (United States)

    Gaikwad, Lokpriya Mohanrao; Teli, Shivagond Nagappa; Majali, Vijay Shashikant; Bhushi, Umesh Mahadevappa

    2016-01-01

    This article presents an application of Six Sigma to reduce supplier quality cost in manufacturing industry. Although there is a wider acceptance of Six Sigma in many organizations today, there is still a lack of in-depth case study of Six Sigma. For the present research the case study methodology was used. The company decided to reduce quality cost and improve selected processes using Six Sigma methodologies. Regarding the fact that there is a lack of case studies dealing with Six Sigma especially in individual manufacturing organization this article could be of great importance also for the practitioners. This paper discusses the quality and productivity improvement in a supplier enterprise through a case study. The paper deals with an application of Six Sigma define-measure-analyze-improve-control methodology in an industry which provides a framework to identify, quantify and eliminate sources of variation in an operational process in question, to optimize the operation variables, improve and sustain performance viz. process yield with well-executed control plans. Six Sigma improves the process performance (process yield) of the critical operational process, leading to better utilization of resources, decreases variations and maintains consistent quality of the process output.

  17. The sigma model on complex projective superspaces

    Energy Technology Data Exchange (ETDEWEB)

    Candu, Constantin; Mitev, Vladimir; Schomerus, Volker [DESY, Hamburg (Germany). Theory Group; Quella, Thomas [Amsterdam Univ. (Netherlands). Inst. for Theoretical Physics; Saleur, Hubert [CEA Saclay, 91 - Gif-sur-Yvette (France). Inst. de Physique Theorique; USC, Los Angeles, CA (United States). Physics Dept.

    2009-08-15

    The sigma model on projective superspaces CP{sup S-1} {sup vertical} {sup stroke} {sup S} gives rise to a continuous family of interacting 2D conformal field theories which are parametrized by the curvature radius R and the theta angle {theta}. Our main goal is to determine the spectrum of the model, non-perturbatively as a function of both parameters. We succeed to do so for all open boundary conditions preserving the full global symmetry of the model. In string theory parlor, these correspond to volume filling branes that are equipped with a monopole line bundle and connection. The paper consists of two parts. In the first part, we approach the problem within the continuum formulation. Combining combinatorial arguments with perturbative studies and some simple free field calculations, we determine a closed formula for the partition function of the theory. This is then tested numerically in the second part. There we propose a spin chain regularization of the CP{sup S-1} {sup vertical} {sup stroke} {sup S} model with open boundary conditions and use it to determine the spectrum at the conformal fixed point. The numerical results are in remarkable agreement with the continuum analysis. (orig.)

  18. The sigma model on complex projective superspaces

    International Nuclear Information System (INIS)

    The sigma model on projective superspaces CPS-1verticalstrokeS gives rise to a continuous family of interacting 2D conformal field theories which are parametrized by the curvature radius R and the theta angle θ. Our main goal is to determine the spectrum of the model, non-perturbatively as a function of both parameters. We succeed to do so for all open boundary conditions preserving the full global symmetry of the model. In string theory parlor, these correspond to volume filling branes that are equipped with a monopole line bundle and connection. The paper consists of two parts. In the first part, we approach the problem within the continuum formulation. Combining combinatorial arguments with perturbative studies and some simple free field calculations, we determine a closed formula for the partition function of the theory. This is then tested numerically in the second part. There we propose a spin chain regularization of the CPS-1verticalstrokeS model with open boundary conditions and use it to determine the spectrum at the conformal fixed point. The numerical results are in remarkable agreement with the continuum analysis. (orig.)

  19. The Sigma Model on Complex Projective Superspaces

    CERN Document Server

    Candu, Constantin; Quella, Thomas; Saleur, Hubert; Schomerus, Volker

    2009-01-01

    The sigma model on complex projective superspaces CP^{S-1|S} gives rise to a continuous family of interacting 2D conformal field theories which are parametrized by the curvature radius R and the theta angle \\theta. Our main goal is to determine the spectrum of the model, non-perturbatively as a function of both parameters. We succeed to do so for all open boundary conditions preserving the full global symmetry of the model. In string theory parlor, these correspond to volume filling branes that are equipped with a monopole line bundle and connection. The paper consists of two parts. In the first part, we approach the problem within the continuum formulation. Combining combinatorial arguments with perturbative studies and some simple free field calculations, we determine a closed formula for the partition function of the theory. This is then tested numerically in the second part. There we propose a spin chain regularization of the CP^{S-1|S} model with open boundary conditions and use it to determine the spect...

  20. The sigma model on complex projective superspaces

    Science.gov (United States)

    Candu, Constantin; Mitev, Vladimir; Quella, Thomas; Saleur, Hubert; Schomerus, Volker

    2010-02-01

    The sigma model on projective superspaces mathbb{C}{mathbb{P}^{S - 1left| S right.}} gives rise to a continuous family of interacting 2D conformal field theories which are parametrized by the curvature radius R and the theta angle θ. Our main goal is to determine the spectrum of the model, non-perturbatively as a function of both parameters. We succeed to do so for all open boundary conditions preserving the full global symmetry of the model. In string theory parlor, these correspond to volume filling branes that are equipped with a monopole line bundle and connection. The paper consists of two parts. In the first part, we approach the problem within the continuum formulation. Combining combinatorial arguments with perturbative studies and some simple free field calculations, we determine a closed formula for the partition function of the theory. This is then tested numerically in the second part. There we extend the proposal of [ arXiv:0908.1081 ] for a spin chain regularization of the mathbb{C}{mathbb{P}^{S - 1left| S right.}} model with open boundary conditions and use it to determine the spectrum at the conformal fixed point. The numerical results are in remarkable agreement with the continuum analysis.

  1. Six Sigma process improvements in automotive parts production

    Directory of Open Access Journals (Sweden)

    M. Soković

    2006-09-01

    Full Text Available Purpose: of this paper: In the paper is presented a Six Sigma project, undertaken within company for production automotive parts, which deals with identification and reduction of production cost in the deburring process for gravity die-castings and improvement of quality level of produced parts.Design/methodology/approach: The objectives are achieved by application of Six Sigma approach to quality improvement project in automotive industry. The applied Six Sigma approach includes team works through several phases: Define, Measure, Analyze, Improve, and Control (DMAIC.Findings: Systematic application of Six Sigma DMAIC tools and methodology within an automotive parts production results with several achievements such are reduction of tools expenses, cost of poor quality and labours expenses.It was shown that Six sigma is an effective way to find out where are the greatest process needs and which are the softest points of the process. Also, Six sigma provide measurable indicators and adequate data for analytical analysis.Research implications: The possibility of application of several Six Sigma tools such are thought process mapping, Pareto diagrams, process mapping, cause and effect matrix, and analysis of variation and capability studies.Practical implications: Improvements through reduced Production time, Control time, Material and Internal scrap have been yield significant financial. Furthermore, this pilot project enabled introduction of Six Sigma methodology in wider range of manufacturer activities.Originality/value: The paper researches the possibility of Six Sigma application within manufacturing process. This paper is of the value to researcher in the field of quality management and quality improvement, as well as to professionals in the manufacturing industry, wherever the quality improvement is an issue.

  2. Dipole moments and transition probabilities of the i 3Pi sub g-b 3Sigma(+) sub u, c 3Pi sub u-a 3Sigma(+) sub g, and i 3Pi sub g-c 3Pi sub u systems of molecular hydrogen

    Science.gov (United States)

    Guberman, Steven L.; Dalgarno, A.

    1992-01-01

    Bonn-Oppenheimer-based ab initio calculations of dipole moments from the i 3Pi sub g-b 3Sigma(+) sub u, c 3Pi sub u-a 3Sigma(+) sub g, and i 3Pi sub g-c 3Pi sub u transitions of H2 have been conducted, to yield a tabulation of the dipole transition probabilities and Franck-Condon factors. These factors are given for transitions originating in the lowest vibrational level of the ground X 1Sigma(+) sub g state.

  3. 6 Sigma DFSS technique which is easy to use

    International Nuclear Information System (INIS)

    This book gives descriptions of 6 sigma DFSS technique. The contents of this book are storm of change, way of problem and solution, importance of customer satisfaction, quality improvement is key of customer satisfaction, quality improvement equals cost cutting, quality aim in perfect level, finding basic cause, data is life, standardization is fundamentals of all activity for improvement, chief, Chang's house, collection of data, setting goal to improve, experiment is the best way, importance of the last step, x control power of 6 sigma and Let's go six-sigma.

  4. The minimal linear sigma model for the Goldstone Higgs

    CERN Document Server

    Feruglio, Ferruccio; Kanshin, Kirill; Machado, Pedro Accioly Nogueira; Rigolin, Stefano; Saa, Sara

    2016-01-01

    In the context of the minimal SO(5) linear {\\sigma}-model, a complete renormalizable Lagrangian -including gauge bosons and fermions- is considered, with the symmetry softly broken to SO(4). The scalar sector describes both the electroweak Higgs doublet and the singlet {\\sigma}. Varying the {\\sigma} mass would allow to sweep from the regime of perturbative ultraviolet completion to the non-linear one assumed in models in which the Higgs particle is a low-energy remnant of some strong dynamics. We analyze the phenomenological implications and constraints from precision observables and LHC data. Furthermore, we derive the d <= 6 effective Lagrangian in the limit of heavy exotic fermions.

  5. Scalar strangeness content of the nucleon and baryon sigma terms

    OpenAIRE

    Ren, Xiu-Lei; Geng, Li-Sheng; Meng, Jie

    2014-01-01

    The scalar strangeness content of the nucleon, characterized by the so-called strangeness-nucleon sigma term, is of fundamental importance in understanding its sea-quark flavor structure. We report a determination of the octet baryon sigma terms via the Feynman-Hellmann theorem by analyzing the latest high-statistics $n_f=2+1$ lattice QCD simulations with covariant baryon chiral perturbation theory up to next-to-next-to-next-to-leading order. In particular, we predict $\\sigma_{\\pi N}=55(1)(4)...

  6. Sigma: Web Retrieval Interface for Nuclear Reaction Data

    Energy Technology Data Exchange (ETDEWEB)

    Pritychenko,B.; Sonzogni, A.A.

    2008-06-24

    The authors present Sigma, a Web-rich application which provides user-friendly access in processing and plotting of the evaluated and experimental nuclear reaction data stored in the ENDF-6 and EXFOR formats. The main interface includes browsing using a periodic table and a directory tree, basic and advanced search capabilities, interactive plots of cross sections, angular distributions and spectra, comparisons between evaluated and experimental data, computations between different cross section sets. Interactive energy-angle, neutron cross section uncertainties plots and visualization of covariance matrices are under development. Sigma is publicly available at the National Nuclear Data Center website at www.nndc.bnl.gov/sigma.

  7. Heat Balanced Bolometer with Sigma-Delta Interface

    OpenAIRE

    Denoual, Matthieu; Pouliquen, Mathieu; Allègre, Gilles; Brouard, D.; Veith, A; De Sagazan, Olivier; Attia, Patrick

    2012-01-01

    This paper presents a single-loop 2nd order sigmadelta interface circuit for a bolometer operating in closed-loop mode. Switched capacitor circuitry is developed to implement the sigma-delta structure. The sigma-delta modulator acts both as digital readout circuit and as a mean of heat feedback. The design approach of the sigma-delta structure and the feedback shaping is explained. The circuit is designed for a realization in AMS CMOS 0.35μm technology.

  8. An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model

    OpenAIRE

    McCrae, Robert R.; Scally, Matthew; Terracciano, Antonio; Abecasis, Gonçalo R; Costa, Paul T.

    2010-01-01

    There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely-unsuccessful search for individual polymorphisms associated with personality traits, we identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two-thirds of a large (N = 3,972) sample of individuals from Sar...

  9. The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events

    OpenAIRE

    Warzecha, Claude C.; Shen, Shihao; Xing, Yi; Carstens, Russ P.

    2009-01-01

    Cell-type and tissue-specific alternative splicing events are regulated by combinatorial control involving both abundant RNA binding proteins as well as those with more discrete expression and specialized functions. Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2) are recently discovered epithelial-specific RNA binding proteins that promote splicing of the epithelial variant of the FGFR2, ENAH, CD44 and CTNND1 transcripts. To catalogue a larger set of splicing events under th...

  10. Alternate stresses and temperature variation as factors of influence of ultrasonic vibration on mechanical and functional properties of shape memory alloys.

    Science.gov (United States)

    Belyaev, Sergey; Volkov, Alexander; Resnina, Natalia

    2014-01-01

    It is known that the main factors in a variation in the shape memory alloy properties under insonation are heating of the material and alternate stresses action. In the present work the experimental study of the mechanical behaviour and functional properties of shape memory alloy under the action of alternate stresses and varying temperature was carried out. The data obtained had demonstrated that an increase in temperature of the sample resulted in a decrease or increase in deformation stress depending on the structural state of the TiNi sample. It was shown that in the case of the alloy in the martensitic state, a decrease in stress was observed, and on the other hand, in the austenitic state an increase in stress took place. It was found that action of alternate stresses led to appearance of strain jumps on the strain-temperature curves during cooling and heating the sample through the temperature range of martensitic transformation under the constant stress. The value of the strain jumps depended on the amplitude of alternate stresses and the completeness of martensitic transformation. It was shown that the heat action of ultrasonic vibration to the mechanical behaviour of shape memory alloys was due to the non-monotonic dependence of yield stress on the temperature. The force action of ultrasonic vibration to the functional properties was caused by formation of additional oriented martensite.

  11. POLARIMETRIC OBSERVATIONS OF {sigma} ORIONIS E

    Energy Technology Data Exchange (ETDEWEB)

    Carciofi, A. C.; Faes, D. M. [Instituto de Astronomia, Geofisica e Ciencias Atmosfericas, Universidade de Sao Paulo, Rua do Matao 1226, Cidade Universitaria, 05508-900 Sao Paulo, SP (Brazil); Townsend, R. H. D. [Department of Astronomy, University of Wisconsin-Madison, Sterling Hall, 475 N. Charter Street, Madison, WI 53706 (United States); Bjorkman, J. E., E-mail: carciofi@usp.br [Ritter Observatory, Department of Physics and Astronomy, University of Toledo, Toledo, OH 43606 (United States)

    2013-03-20

    Some massive stars possess strong magnetic fields that confine plasma in the circumstellar environment. These magnetospheres have been studied spectroscopically, photometrically, and, more recently, interferometrically. Here we report on the first firm detection of a magnetosphere in continuum linear polarization, as a result of monitoring {sigma} Ori E at the Pico dos Dias Observatory. The non-zero intrinsic polarization indicates an asymmetric structure whose minor elongation axis is oriented 150. Degree-Sign 0 east of the celestial north. A modulation of the polarization was observed with a period of half of the rotation period, which supports the theoretical prediction of the presence of two diametrally opposed, corotating blobs of gas. A phase lag of -0.085 was detected between the polarization minimum and the primary minimum of the light curve, suggestive of a complex shape of the plasma clouds. We present a preliminary analysis of the data with the Rigidly Rotating Magnetosphere model, which could not reproduce simultaneously the photometric and polarimetric data. A toy model comprising two spherical corotating blobs joined by a thin disk proved more successful in reproducing the polarization modulation. With this model we were able to determine that the total scattering mass of the thin disk is similar to the mass of the blobs (2M{sub b}/M{sub d} = 1.2) and that the blobs are rotating counterclockwise on the plane of the sky. This result shows that polarimetry can provide a diagnostic of the geometry of clouds, which will serve as an important constraint for improving the Rigidly Rotating Magnetosphere model.

  12. Precision measurement of $\\sigma(e^+e^-\\rightarrow\\pi^+\\pi^-\\gamma)/\\sigma(e^+e^-\\rightarrow \\mu^+\\mu^-\\gamma)$ and determination of the $\\pi^+\\pi^-$ contribution to the muon anomaly with the KLOE detector

    CERN Document Server

    Babusci, D; Balwierz-Pytko, I; Bencivenni, G; Bini, C; Bloise, C; Bossi, F; Branchini, P; Budano, A; Caldeira Balkestahl, L; Capon, G; Ceradini, F; Ciambrone, P; Curciarello, F; Czerwinski, E; Dane, E; De Leo, V; De Lucia, E; De Robertis, G; De Santis, A; De Simone, P; Di Domenico, A; Di Donato, C; Domenici, D; Erriquez, O; Fanizzi, G; Felici, G; Fiore, S; Franzini, P; Gauzzi, P; Giardina, G; Giovannella, S; Gonnella, F; Graziani, E; Happacher, F; Heijkenskjold, L; Hoistad, B; Iafolla, L; Iarocci, E; Jacewicz, M; Johansson, T; Kluge, W; Kupsc, A; Lee-Franzini, J; Loddo, F; Lukin, P; Mandaglio, G; Martemianov, M; Martini, M; Mascolo, M; Messi, R; Miscetti, S; Morello, G; Moricciani, D; Moskal, P; Muller, S; Nguyen, F; Passeri, A; Patera, V; Prado Longhi, I; Ranieri, A; Redmer, C F; Santangelo, P; Sarra, I; Schioppa, M; Sciascia, B; Silarski, M; Taccini, C; Tortora, L; Venanzoni, G; Versaci, R; Wislicki, W; Wolke, M; Zdebik, J

    2013-01-01

    We have measured the ratio $\\sigma(e^+e^-\\rightarrow\\pi^+\\pi^-\\gamma)/\\sigma(e^+e^-\\rightarrow \\mu^+\\mu^-\\gamma)$, with the KLOE detector at DA$\\Phi$NE for a total integrated luminosity of $\\sim$ 240 pb$^{-1}$. From this ratio we obtain the cross section $\\sigma(e^+e^-\\rightarrow\\pi^+\\pi^-)$. From the cross section we determine the pion form factor $|F_\\pi|^2$ and the two-pion contribution to the muon anomaly $a_\\mu$ for $0.592

  13. Quality and Competitiveness: A Lean Six Sigma Approach

    Directory of Open Access Journals (Sweden)

    Irina-Virginia Drăgulănescu

    2015-11-01

    Full Text Available Originally developed to improve the quality and production efficiency, Lean Six Sigma is now widely adopted in other non-manufacturing sectors such as financial, trade, services, etc. The methodology known as Lean Six Sigma combines the Six Sigma techniques, ‒ which allow companies to reduce manufacturing defects ‒ and the Lean Manufacturing principles, ‒ which help companies benefit from faster processing for lower costs and with superior quality. As a result of the research, the authors observed that, despite growing popularity and impressive outcomes obtained by some companies, the Lean Six Sigma model does not always offer the expected results. However, the research has shown that the analysed company, operating in the field of courier services has managed to boost productivity and competitiveness by implementing measures that generated added value.

  14. Establishing a Lean Six Sigma Program in Higher Education

    KAUST Repository

    Svensson, Carsten

    2013-09-12

    Purpose: The objective of this paper is a contribution to the body of Lean Six Sigma knowledge within the vertical of higher education institutions. The paper will review the initial phase of an implementation and highlight future challenges. Approach: The observations presented in this paper, originates from rolling out a large lean six sigma implementation at a newly established university. The paper is supported with secondary data from literature. Findings: The paper will discuss the challenges of applying the lean six sigma method in a complex transactional environment. Research limitations: This paper is based on an empirical study of a single instance and authors’ experiences as practitioners. Originality: This paper is the first description of what is believed to be one of the largest implementations of Lean Six Sigma in higher education.

  15. Noise Study of a Heat Balanced Sigma-Delta Bolometer

    OpenAIRE

    Denoual, Matthieu; Brouard, D.; Veith, A; Pouliquen, Mathieu; Attia, Patrick; Allègre, Gilles

    2013-01-01

    The paper presents the modeling of a heat balanced sigma-delta bolometer with Matlab Simulink®. In particular, the noise sources are modeled to enable the evaluation of the output measurement resolution.

  16. The Six Sigma initiative at Mount Sinai Medical Center.

    Science.gov (United States)

    Chassin, Robert

    2008-01-01

    Lean Six Sigma, in various forms, has been used widely in many Fortune 500 companies. Motorola, General Electric, Sony, American Express, and Bechtel all use Six Sigma to improve quality and performance. While the impact of this methodology has been documented extensively by the press in manufacturing and transactional settings, less evidence is available regarding its utility in health care environments. Mount Sinai Medical Center initiated a Six Sigma program in 2000 to determine its applicability and value in a large academic medical center. This article discusses Mount Sinai Medical Center's experience adapting this methodology to improve both patient care and business processes and outcomes. We present an overview of Six Sigma, and offer examples of projects undertaken using this data-driven approach to performance improvement. Lastly, the article provides insights and lessons learned regarding this organization-wide experience.

  17. Measurement of $R =\\sigma_{L} /\\sigma_{T}$ in deep-inelastic scattering on nuclei

    CERN Document Server

    Airapetian, A; Amarian, M; Ammosov, V V; Aschenauer, E C; Avakian, R; Avetisian, A; Avetisian, E; Bailey, P; Baturin, V; Baumgarten, C; Beckmann, M; Belostotskii, S; Blok, H P; Böttcher, Helmut B; Borisov, A; Bouhali, O; Bouwhuis, M; Brack, J; Brauksiepe, S; Brüll, A; Brunn, I; Capitani, G P; Chiang Huan Ching; Ciullo, G; Court, G R; Dalpiaz, P F; De Leo, R; De Nardo, L; De Sanctis, E; Devitsin, E G; De Witt-Huberts, P K A; Di Nezza, P; Düren, M; Ehrenfried, M; Elalaoui-Moulay, A; Elbakian, G M; Ellinghaus, F; Elschenbroich, U; Ely, J; Fabbri, R; Fantoni, A; Feshchenko, A; Felawka, L; Fischer, H; Fox, B; Franz, J; Frullani, S; Gärber, Y; Gapienko, G S; Gapienko, V A; Garibaldi, F; Garutti, E; Gavrilov, G E; Gharibian, V; Graw, G; Grebenyuk, O; Green, P W; Greeniaus, L G; Gute, A; Haeberli, W; Hafidi, K; Hartig, M; Hasch, D; Heesbeen, D; Heinsius, F H; Henoch, M; Hertenberger, R; Hesselink, W H A; Holler, Y; Hommez, B; Yarygin, G; Izotov, A; Jackson, H E; Jgoun, A; Kaiser, R; Kinney, E R; Kiselev, A; Kitching, P; Königsmann, K C; Kolster, H; Kopytine, M L; Korotkov, V A; Kotik, E; Kozlov, V; Krauss, B; Krivokhizhin, V G; Lagamba, L; Lapikas, L; Laziev, A; Lenisa, P; Liebing, P; Lindemann, T; Lorenzon, W; Makins, N C R; Marukian, G; Masoli, F; Menden, F; Mexner, V; Meyners, N; Miklukho, O; Miller, C A; Muccifora, V; Nagaitsev, A P; Nappi, E; Naryshkin, Yu; Nass, A; Negodaeva, K; Nowak, Wolf-Dieter; Oganessyan, K; Ohsuga, H; Orlandi, G; Podyachev, S P; Potashov, S Yu; Potterveld, D H; Raithel, M; Reggiani, D; Reimer, P; Reischl, A; Reolon, A R; Rith, K; Rosner, G; Rostomyan, A; Ryckbosch, D; Sakemi, Y; Sanjiev, I; Sato, F; Savin, I; Scarlett, C; Schäfer, A; Schill, C; Schnell, G; Schüler, K P; Schwind, A; Seibert, J; Seitz, B; Shanidze, R G; Shibata, T A; Shutov, V B; Simani, M C; Sinram, K; Stancari, M D; Statera, M; Steffens, E; Steijger, J J M; Stewart, J; Stösslein, U; Suetsugu, K; Tanaka, H; Taroian, S P; Terkulov, A R; Tessarin, S; Thomas, E; Tkabladze, A V; Tytgat, M; Urciuoli, G M; van der Steenhoven, G; Van de Vyver, R; Vetterli, Martin C; Vikhrov, V V; Vincter, M G; Visser, J; Volmer, J; Weiskopf, C; Wendland, J; Wilbert, J; Wise, T; Yen, S; Yoneyama, S; Zihlmann, B; Zohrabyan, H G

    2002-01-01

    Cross section ratios for deep-inelastic scattering from $^3$He, $^{14}$N and $^{84}$Kr with respect to $^2$H have been measured by the HERMES collaboration at DESY using a 27.5 GeV positron beam. The data cover a range in the Bjorken scaling variable $x$ between 0.010 and 0.65, the negative squared four-momentum transfer $Q^2$ varies from 0.5 to 15 GeV$^2$, while at small values of $x$ and $Q^2$, the virtual photon polarisation parameter $\\epsilon$ extends to lower values than previous measurements. From the dependence of the data on $\\epsilon$, values for $R_A/R_D$ with $R$ the ratio $\\sigma_L / \\sigma_T$ of longitudinal to transverse DIS cross sections have been derived and found to be consistent with unity. %The data are compared to measurements performed by NMC, E665, and SLAC %on $^4$He and $^{12}$C, and are found to be different for %$x <$ 0.06 and $Q^2 <$ 1.5 GeV$^2$.

  18. Alternative security

    International Nuclear Information System (INIS)

    This book contains the following chapters: The Military and Alternative Security: New Missions for Stable Conventional Security; Technology and Alternative Security: A Cherished Myth Expires; Law and Alternative Security: Toward a Just World Peace; Politics and Alternative Security: Toward a More Democratic, Therefore More Peaceful, World; Economics and Alternative Security: Toward a Peacekeeping International Economy; Psychology and Alternative Security: Needs, Perceptions, and Misperceptions; Religion and Alternative Security: A Prophetic Vision; and Toward Post-Nuclear Global Security: An Overview

  19. A literary study on the bonding of the Six Sigma with the Service Quality for the enrichment of the Service Sector(S for the Construction Projects

    Directory of Open Access Journals (Sweden)

    R.Surya Kiran

    2014-09-01

    Full Text Available Purpose: This research paper focusses on the merger of the six sigma with the service quality for the improvement of the services for the service sectors . Approach: This paper approaches towards the resaons for the poor performance of the six sigma in the service sectors ,key factors necessary for the implementation of the six sigma and the barriers / difficulties to the implementation of the same . Findings: This paper drives towards the problems ,outcomes and the benefits obtained through the implementation of the six sigma for the service sectors and the significant and the insignificant contribution concerned with the implementation fo the six sigma towards the service quality .The companies or the organisation who had been the beneficiaries is also discussed . Implications:The implications of this paper is to call for the redisgning a framework necessary for the implementation of the six sigma with the service quality for the other major sectors as well . Originality : This paper provides a fresh look into the six sigma applications to services by combining the thorough analysis of the concepts .

  20. A PRELIMINARY STUDY FOR SIX SIGMA IMPLEMENTATION IN LASER IN SITU KERATOMILEUSIS (LASIK SURGERIES

    Directory of Open Access Journals (Sweden)

    Mehmet Tolga Taner

    2014-01-01

    Full Text Available The purpose of this study is to show how a private eye care center in Turkey developed a Six Sigma infrastructure to investigate the root causes of complications occuring during LASIK surgeries. To analyze the collected data, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control(DMAIC improvement cycle such as SIPOC table, Fishbone Diagram and, Failure, Mode and Effect Analysis were implemented. Experience of the refractive surgeons, type of microkeratome and hygiene of microkeratome were identified to be Critical-to-Quality (CTQ factors for a successful LASIK surgery. The most frequent complications of LASIK surgeries were found to be dry eye syndrome, subconjunctival haemorrhage and flap edge melt. The process sigma level was found to be 3.7135.

  1. Semiclassical Distorted Wave Model Analysis of the $(\\pi^-,K^+)$ $\\Sigma$ Formation Inclusive Spectrum

    CERN Document Server

    Kohno, M; Kawai, M; Ogata, K; Watanabe, Y

    2006-01-01

    $(\\pi^-,K^+)$ hyperon production inclusive spectra with $p_\\pi =1.2$ GeV/c measured at KEK on $^{12}$C and $^{28}$Si are analyzed by the semiclassical distorted wave model. Single-particle wave functions of the target nucleus are treated using Wigner transformation. This method is able to account for the energy and angular dependences of the elementary process in nuclear medium without introducing the factorization approximation frequently employed. Calculations of the $(\\pi^+,K^+)$ $\\Lambda$ formation process, for which there is no free parameter since the $\\Lambda$ s.p. potential is known, demonstrate that the present model is useful to describe inclusive spectra. It is shown that in order to account for the experimental data of the $\\Sigma^-$ formation spectra a repulsive $\\Sigma$-nucleus potential is necessary whose magnitude is not so strong as around 100 MeV previously suggested.

  2. Conventional and Machine Learning Assisted High Sigma Analysis

    OpenAIRE

    Wu, Wei

    2016-01-01

    Statistical circuit simulation exhibits increasing importance for circuit designs under process variations. In particular, high sigma analysis is needed to optimize highly-duplicated standard cells, where an extremely rare circuit failure event could lead to catastrophe of the entire chip. Conventional importance sampling (IS) approaches perform high sigma analysis efficiently at low dimensionality, but perform poorly either when there are a larger number of process variation variables, or wh...

  3. Improved Nucleon Properties in the Extended Quark Sigma Model

    CERN Document Server

    Abu-Shady, M

    2013-01-01

    The quark sigma model describes the quarks interacting via exchange the pions and sigma meson fields. A new version of mesonic potential is suggested in the frame of some aspects of the quantum chromodynamics (QCD). The field equations have been solved in the mean-field approximation for the hedgehog baryon state. The obtained results are compared with previous works and other models. We conclude that the suggested mesonic potential successfully calculates nucleon properties.

  4. Řízení Six Sigma projektů.

    OpenAIRE

    Dobeš, Petr

    2009-01-01

    Diploma thesis of "Management of Six Sigma projects" is dealing with possibilities of using this technique in specific continuous improvement projects. Main goal is to analyse tools of this method on real situation and proof that Six Sigma is usable to manage this kind of projects. This work will include necessary theoretical basics from project management scope based on generally approved PMBOK methodology. Part of this analysis will be concerned on comparison of PMBOK principles and Six Sig...

  5. A Comment on the Renormalization of the Nonlinear Sigma Model

    CERN Document Server

    Bettinelli, D; Quadri, A; Bettinelli, Daniele; Ferrari, Ruggero; Quadri, Andrea

    2007-01-01

    We consider the recently proposed renormalization procedure for the nonlinear sigma model, consisting in the recursive subtraction of the divergences in a symmetric fashion. We compare this subtraction with the conventional procedure in power counting renormalizable (PCR) theories. We argue that symmetric subtraction in the nonlinear sigma model does not follow the lore by which nonrenormalizable theories require an infinite number of parameter fixings. Our conclusion is that only two parameters can be consistently used as physical constants.

  6. Sistem Informasi Kinerja Layanan Laboratorium Medis dengan Metode Six Sigma

    OpenAIRE

    Anindita Kusumastuti Dewi; Ibnu Widiyanto

    2016-01-01

    Medical Laboratory currently holds a very important role in medicine. Evaluation of laboratory quality plays a very important to maintain accurate laboratory results. This study aims to design an information system performance based on the same perception of medical laboratory services from customers using Six Sigma methods and frameworks using ServQual questionnaire. Selection of Six Sigma itself is based on this method can measure the extent to which each process deviates from its purpose a...

  7. Quality management in enterprise using Six Sigma method

    OpenAIRE

    M. Spilka; M. Sakaluk; Kania, A.

    2012-01-01

    Purpose: The article includes characteristic of the extrusion moulding as the most popular method of the plastics processing industry. Statistical analysis and a test of explanation of cause of so-called foam collapsing in the chosen productive enterprise were presented. Six Sigma method was used to the problem solution.Design/methodology/approach: In this paper a detailed plan for implementation of Six Sigma quality management conception in order to eliminate the collapsing effect of polyeth...

  8. IMPROVE MACHINING PROCESS CAPABILITY BY USING SIX-SIGMA

    OpenAIRE

    Sanjit Ray; Prasun Das

    2011-01-01

    Abstract: Six-Sigma is an improvement strategy for achieving customer satisfaction by reducing variation and thus producing products and services better, faster and cheaper. This study presents a Six-Sigma project of an automotive plant illustrating how the DMAIC methodology and statistical techniques were applied to resolve the issue of manufacturing process capability. This project has substantially benefit ted the organization by reducing the variation of bore size of crank case, achieving...

  9. N=2 supersymmetric sigma-models in AdS

    CERN Document Server

    Butter, Daniel

    2011-01-01

    We construct the most general N=2 supersymmetric nonlinear sigma-model in four-dimensional anti-de Sitter (AdS) space in terms of N=1 chiral superfields. The target space is shown to be a non-compact hyperkahler manifold restricted to possess a special Killing vector field. A remarkable property of the sigma-model constructed is that the algebra of OSp(2|4) transformations is closed off the mass shell.

  10. A heat balanced sigma-delta uncooled bolometer

    OpenAIRE

    Denoual, Matthieu; Brouard, D.; Veith, A; De Sagazan, Olivier; Pouliquen, Mathieu; Attia, Patrick; Lebrasseur, E.; Mita, Y.; Allègre, Gilles

    2014-01-01

    This paper describes a heat balanced bolometer with an integrated CMOS sigma-delta interface. The sigma-delta interface accomplishes both the analogue-to-digital conversion and the heat feedback and therefore no other digital core is required. The heat feedback is implemented using a capacitively coupled electrical substitution technique with a digitally modulated signal that enables feedback linearization. Proof of concept is experimentally demonstrated with a polymer-type resistive bolomete...

  11. Does the light and broad $\\sigma$(500) exist?

    CERN Document Server

    Törnqvist, N A

    1999-01-01

    The lightest scalar and pseudoscalar nonets are discussed within the framework of the broken U3$\\times$U3 linear sigma model, and it is shown that already at the tree level this model works remarkably well predicting scalar masses and couplings not far from present experimental values, when all parameters are fixed from the pseudoscalar masses and decay constants. It is argued that this strongly suggests that the light and very broad $\\sigma$ resonance exists near 500 MeV.

  12. On coincidence of Alday-Maldacena-regularized $\\sigma$-model and Nambu-Goto areas of minimal surfaces

    OpenAIRE

    Popolitov, A.

    2007-01-01

    For the $\\sigma$-model and Nambu-Goto actions, values of the Alday-Maldacena-regularized actions are calculated on solutions of the equations of motion with constant non-regularized Lagrangian. It turns out that these values coincide up to a factor, independent of boundary conditions.

  13. Discretization of the nonlinear O(3) sigma model

    CERN Document Server

    Kamata, Masaru; Tadokoro, Yuuki

    2016-01-01

    We derive a discretized version of the nonlinear O(3) sigma model through a discrete theory of complex analysis of Mercat. Adopting a simple two-dimensional rectangular lattice, we obtain a discrete energy E^{disc.} and a discrete area \\cal{A}(f)^{disc.}, where a function f is related to a stereographic projection governed by a unit vector {\\boldmath n} of the model. Both discrete energy and area satisfy the inequality E^{disc.} \\ge |\\cal{A}(f)^{disc.}|, which is saturated if and only if the function f is discrete (anti-)holomorphic. The vector {\\boldmath n} parametrizing the function describes classical discrete (anti-)instanton solutions on the lattice. Two discrete instanton solutions are illustrated, which are derived from polynomials up to degree two in z. Except for a factor 2, the discrete energy and the area tend to the usual continuous energy E and the area \\cal{A}(f)=4 \\pi q, q \\in \\pi_2(S^2), respectively, as the lattice spacings tend to zero.

  14. Kinetics of sigma phase formation in a Duplex Stainless Steel

    Directory of Open Access Journals (Sweden)

    Rodrigo Magnabosco

    2009-09-01

    Full Text Available This work determines the kinetics of sigma phase formation in UNS S31803 Duplex Stainless Steel (DSS, describing the phase transformations that occur in isothermal aging between 700 and 900 ºC for time periods up to 1032 hours, allowing the determination of the Time-Temperature-Precipitation (TTP diagram for sigma phase and proposing a model to predict the kinetics of sigma phase formation using a Johnson-Mehl-Avrami (JMA type expression. The higher kinetics of sigma phase formation occurs at 850 ºC. However, isothermal aging between 700 and 900 ºC for time periods up to 1032 hours are not sufficient to the establishment of thermodynamic equilibrium. Activation energy for both nucleation and growth of sigma phase is determined (185 kJ.mol-1 and its value is equivalent to the activation energy for Cr diffusion in ferrite, indicating that diffusion of Cr is probably the major thermally activated process involved in sigma phase formation. The determined JMA type expression presents good fit with experimental data between 700 and 850 ºC.

  15. Lean sigma--will it work for healthcare?

    Science.gov (United States)

    Bahensky, James A; Roe, Janet; Bolton, Romy

    2005-01-01

    The manufacturing industry has been using Lean Sigma for years in pursuit of continuous improvement to obtain a competitive advantage. The objectives of these efforts are to use the Lean techniques for reducing cycle times and the Six Sigma concepts for reducing product defects. The Iowa Business Council with several advocates worked with the University of Iowa Hospital and Clinics (UIHC) and two other Iowa hospitals to determine whether Lean Sigma is adaptable in healthcare. A team of 15 people at UIHC used the Kaizen Breakthrough Methodology over a five-day period in an aggressive identification and elimination of non-value added activities in Radiology CT scanning. The results exceeded the initial project objectives and indicated that Lean Sigma is applicable in healthcare. Overall, the Lean Sigma project increased revenue by approximately $750,000 per year. The Kaizen process proved to be successful and interesting. Within three days, the team installed new work flow processes. This implementation-oriented approach is what differentiates Lean Sigma from other quality improvement processes. PMID:15682675

  16. Updated radio $\\Sigma-D$ relation for Galactic supernova remnants

    CERN Document Server

    Pavlović, M Z; Vukotić, B; Urošević, D

    2014-01-01

    We present updated empirical radio surface-brightness-to-diameter ($\\Sigma-D$) relation for supernova remnants (SNRs) in our Galaxy. Our original calibration sample of Galactic SNRs with independently determined distances (Pavlovi\\'c et al. 2013, hereafter Paper I) is reconsidered and updated with data which became available in the past two years. The orthogonal fitting procedure and probability-density-function-based (PDF) method are applied to the calibration sample in the $\\log \\Sigma - \\log D$ plane. Orthogonal regression keeps $\\Sigma-D$ and $D-\\Sigma$ relations invariant. Our previous Monte Carlo simulations verified that the slopes of the empirical $\\Sigma-D$ relation should be determined by using orthogonal regression. Updated calibration sample contains 65 shell SNRs. 6 new Galactic SNRs are added to the sample from Paper I, one is omitted and distances are changed for 10 SNRs. The slope derived here is slightly steeper ($\\beta \\approx 5.2$) than $\\Sigma-D$ slope in Paper I ($\\beta \\approx 4.8$). The...

  17. Lean sigma--will it work for healthcare?

    Science.gov (United States)

    Bahensky, James A; Roe, Janet; Bolton, Romy

    2005-01-01

    The manufacturing industry has been using Lean Sigma for years in pursuit of continuous improvement to obtain a competitive advantage. The objectives of these efforts are to use the Lean techniques for reducing cycle times and the Six Sigma concepts for reducing product defects. The Iowa Business Council with several advocates worked with the University of Iowa Hospital and Clinics (UIHC) and two other Iowa hospitals to determine whether Lean Sigma is adaptable in healthcare. A team of 15 people at UIHC used the Kaizen Breakthrough Methodology over a five-day period in an aggressive identification and elimination of non-value added activities in Radiology CT scanning. The results exceeded the initial project objectives and indicated that Lean Sigma is applicable in healthcare. Overall, the Lean Sigma project increased revenue by approximately $750,000 per year. The Kaizen process proved to be successful and interesting. Within three days, the team installed new work flow processes. This implementation-oriented approach is what differentiates Lean Sigma from other quality improvement processes.

  18. Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

    Directory of Open Access Journals (Sweden)

    Holers V Michael

    2007-05-01

    Full Text Available Abstract Background The posttraumatic response to traumatic brain injury (TBI is characterized, in part, by activation of the innate immune response, including the complement system. We have recently shown that mice devoid of a functional alternative pathway of complement activation (factor B-/- mice are protected from complement-mediated neuroinflammation and neuropathology after TBI. In the present study, we extrapolated this knowledge from studies in genetically engineered mice to a pharmacological approach using a monoclonal anti-factor B antibody. This neutralizing antibody represents a specific and potent inhibitor of the alternative complement pathway in mice. Methods A focal trauma was applied to the left hemisphere of C57BL/6 mice (n = 89 using a standardized electric weight-drop model. Animals were randomly assigned to two treatment groups: (1 Systemic injection of 1 mg monoclonal anti-factor B antibody (mAb 1379 in 400 μl phosphate-buffered saline (PBS at 1 hour and 24 hours after trauma; (2 Systemic injection of vehicle only (400 μl PBS, as placebo control, at identical time-points after trauma. Sham-operated and untreated mice served as additional negative controls. Evaluation of neurological scores and analysis of brain tissue specimens and serum samples was performed at defined time-points for up to 1 week. Complement activation in serum was assessed by zymosan assay and by murine C5a ELISA. Brain samples were analyzed by immunohistochemistry, terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL histochemistry, and real-time RT-PCR. Results The mAb 1379 leads to a significant inhibition of alternative pathway complement activity and to significantly attenuated C5a levels in serum, as compared to head-injured placebo-treated control mice. TBI induced histomorphological signs of neuroinflammation and neuronal apoptosis in the injured brain hemisphere of placebo-treated control mice for up to 7 days. In contrast, the

  19. Observation of $\\eta_{c}$ decay into $\\Sigma^{+}\\bar{\\Sigma}^{-}$ and $\\Xi^{-}\\bar{\\Xi}^{+}$ final states

    CERN Document Server

    Ablikim, M; Albayrak, O; Ambrose, D J; An, F F; An, Q; Bai, J Z; Ban, Y; Becker, J; Bennett, J V; Bertani, M; Bian, J M; Boger, E; Bondarenko, O; Boyko, I; Briere, R A; Bytev, V; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, J C; Chen, M L; Chen, S J; Chen, X; Chen, Y B; Cheng, H P; Chu, Y P; Coccetti, F; Cronin-Hennessy, D; Dai, H L; Dai, J P; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; Ding, W M; Ding, Y; Dong, L Y; Dong, M Y; Du, S X; Fang, J; Fang, S S; Fava, L; Feldbauer, F; Feng, C Q; Ferroli, R B; Fu, C D; Fu, J L; Gao, Y; Geng, C; Goetzen, K; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, Y P; Han, Y L; Harris, F A; He, K L; He, M; He, Z Y; Held, T; Heng, Y K; Hou, Z L; Hu, H M; Hu, J F; Hu, T; Huang, G M; Huang, G S; Huang, J S; Huang, X T; Huang, Y P; Hussain, T; Ji, C S; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L L; Jiang, X S; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Jing, F F; Kalantar-Nayestanaki, N; Kavatsyuk, M; Kornicer, M; Kuehn, W; Lai, W; Lange, J S; Li, C H; Li, Cheng; Li, Cui; Li, D M; Li, F; Li, G; Li, H B; Li, J C; Li, K; Li, Lei; Li, Q J; Li, S L; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, X R; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Liao, X T; Liu, B J; Liu, C L; Liu, C X; Liu, C Y; Liu, F H; Liu, Fang; Liu, Feng; Liu, H; Liu, H H; Liu, H M; Liu, H W; Liu, J P; Liu, K Y; Liu, Kai; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Z A; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H; Lu, G R; Lu, H J; Lu, J G; Lu, Q W; Lu, X R; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lv, M; Ma, C L; Ma, F C; Ma, H L; Ma, Q M; Ma, S; Ma, T; Ma, X Y; Ma, Y; Maas, F E; Maggiora, M; Malik, Q A; Mao, Y J; Mao, Z P; Messchendorp, J G; Min, J; Min, T J; Mitchell, R E; Mo, X H; Morales, C Morales; Motzko, C; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nicholson, C; Nikolaev, I B; Ning, Z; Olsen, S L; Ouyang, Q; Pacetti, S; Park, J W; Pelizaeus, M; Peng, H P; Peters, K; Ping, J L; Ping, R G; Poling, R; Prencipe, E; Qi, M; Qian, S; Qiao, C F; Qin, X S; Qin, Y; Qin, Z H; Qiu, J F; Rashid, K H; Rong, G; Ruan, X D; Sarantsev, A; Schaefer, B D; Schulze, J; Shao, M; Shen, C P; Shen, X Y; Sheng, H Y; Shepherd, M R; Song, X Y; Spataro, S; Spruck, B; Sun, D H; Sun, G X; Sun, J F; Sun, S S; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Toth, D; Ullrich, M; Varner, G S; Wang, B; Wang, B Q; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, Q; Wang, Q J; Wang, S G; Wang, X L; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z Y; Wei, D H; Wei, J B; Weidenkaff, P; Wen, Q G; Wen, S P; Werner, M; Wiedner, U; Wu, L H; Wu, N; Wu, S X; Wu, W; Wu, Z; Xia, L G; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, G M; Xu, H; Xu, Q J; Xu, X P; Xu, Z R; Xue, F; Xue, Z; Yan, L; Yan, W B; Yan, Y H; Yang, H X; Yang, Y; Yang, Y X; Ye, H; Ye, M; Ye, M H; Yu, B X; Yu, C X; Yu, H W; Yu, J S; Yu, S P; Yuan, C Z; Yuan, Y; Zafar, A A; Zallo, A; Zeng, Y; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, S H; Zhang, X J; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y S; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, H S; Zhao, J W; Zhao, K X; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q Z; Zhao, S J; Zhao, T C; Zhao, X H; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, Y H; Zhong, B; Zhong, J; Zhong, Z; Zhou, L; Zhou, X K; Zhou, X R; Zhu, C; Zhu, K; Zhu, K J; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y M; Zhu, Y S; Zhu, Z A; Zhuang, J; Zou, B S; Zou, J H

    2012-01-01

    Using a data sample of $2.25\\times10^{8}$ $J/\\psi$ events collected with the BESIII detector, we present the first observation of the decays of $\\eta_{c}$ mesons to $\\Sigma^{+}\\bar{\\Sigma}^{-}$ and $\\Xi^{-}\\bar{\\Xi}^{+}$. The branching fractions are measured to be $(2.11\\pm0.28_{\\rm stat.}\\pm0.18_{\\rm syst.}\\pm0.50_{\\rm PDG})\\times10^{-3}$ and $(0.89\\pm0.16_{\\rm stat.}\\pm0.08_{\\rm syst.}\\pm0.21_{\\rm PDG})\\times10^{-3}$ for $\\eta_{c} \\to \\Sigma^{+}\\bar{\\Sigma}^{-}$ and $\\Xi^{-}\\bar{\\Xi}^{+}$, respectively. These branching fractions provide important information on the helicity selection rule in charmonium-decay processes.

  20. Observation of eta(c) decay into Sigma(+)(Sigma)over-bar(-) and (sic)(-)over bar>(+) final states

    NARCIS (Netherlands)

    Ablikim, M.; Achasov, M. N.; Albayrak, O.; Ambrose, D. J.; An, F. F.; An, Q.; Bai, J. Z.; Ban, Y.; Becker, J.; Bennett, J. V.; Bertani, M.; Bian, J. M.; Boger, E.; Bondarenko, O.; Boyko, I.; Briere, R. A.; Bytev, V.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J.C.; Chen, M.L.; Chen, S. J.; Chen, X.; Chen, Y.B.; Cheng, H. P.; Chu, Y. P.; Coccetti, F.; Cronin-Hennessy, D.; Dai, H. L.; Dai, J.P.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; Ding, W. M.; Ding, Y.; Dong, L. Y.; Dong, M. Y.; Du, S. X.; Fang, J.; Fang, S. S.; Fava, L.; Feldbauer, F.; Feng, C. Q.; Ferroli, R. B.; Fu, C. D.; Fu, J. L.; Gao, Y.; Geng, C.; Goetzen, K.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A.Q.; Guo, L. B.; Guo, Y. P.; Han, Y. L.; Harris, F. A.; He, K. L.; He, M.; He, Z. Y.; Held, T.; Heng, Y. K.; Hou, Z. L.; Hu, H. M.; Hu, J. F.; Hu, T.; Huang, G. M.; Huang, G. S.; Huang, J.S.; Huang, X.T.; Huang, Y. P.; Hussain, T.; Ji, C. S.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L.L.; Jiang, X. S.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Jing, F. F.; Kalantar-Nayestanaki, N.; Kavatsyuk, M.; Kornicer, M.; Kuehn, W.; Lai, W.; Lange, J.S.; Li, C. H.; Li, Cheng; Li, Cui; Li, D. M.; Li, F.; Li, G.; Li, H.B.; Li, J. C.; Li, K.; Li, Lei; Li, Q. J.; Li, S.L.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, X. R.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y.T.; Liao, G.R.; Liao, X. T.; Liu, B. J.; Liu, Cheng; Liu, C.X.; Liu, C.Y.; Liu, F.H.; Liu, Fang; Liu, Feng; Liu, H.; Liu, H. H.; Liu, H. M.; Liu, H. W.; Liu, J. P.; Liu, K.Y.; Liu, Kai; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Z. A.; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H.; Lu, G. R.; Lu, H. J.; Lu, J.G.; Lu, Q. W.; Lu, X. R.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X.L.; Lv, M.; Ma, C.L.; Ma, F. C.; Ma, H. L.; Ma, Q. M.; Ma, S.; Ma, T.; Ma, X. Y.; Ma, Y.; Maas, F.E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Messchendorp, J. G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Morales, C. Morales; Motzko, C.; Muchnoi, N. Yu; Muramatsu, H.; Nefedov, Y.; Nicholson, C.; Nikolaev, I. B.; Ning, Z.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Park, J.W.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Ping, J. L.; Ping, R. G.; Poling, R.; Prencipe, E.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, X. S.; Qin, Y.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Rong, G.; Ruan, X. D.; Sarantsev, A.; Schaefer, B. D.; Schulze, J.; Shao, M.; Shen, C. P.; Shen, X. Y.; Sheng, H. Y.; Shepherd, M. R.; Song, X. Y.; Spataro, S.; Spruck, B.; Sun, D. H.; Sun, G. X.; Sun, J.F.; Sun, S. S.; Sun, Y.J.; Sun, Y.Z.; Sun, Z.J.; Sun, Z.T.; Tang, C.J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Toth, D.; Ullrich, M.; Varner, G. S.; Wang, B.; Wang, B.Q.; Wang, D.; Wang, D.Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, Q.; Wang, Q. J.; Wang, S. G.; Wang, X. L.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z.Y.; Wei, D. H.; Wei, J.B.; Weidenkaff, P.; Wen, Q. G.; Wen, S. P.; Wiedner, U.; Wu, L.H.; Wu, N.; Wu, S.X.; Wu, W.; Wu, Z.; Xia, L. G.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, G. M.; Xu, H.; Xu, Q.J.; Xu, X. P.; Xu, Z. R.; Xue, F.; Xue, Z.; Yan, L.; Yan, W. B.; Yan, Y. H.; Yang, H. X.; Yang, Y.; Yang, Y. X.; Ye, H.; Ye, M.; Ye, M. H.; Yu, B. X.; Yu, C. X.; Yu, H. W.; Yu, J. S.; Yu, S. P.; Yuan, C. Z.; Yuan, Y.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, S. H.; Zhang, X. J.; Zhang, X. Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. S.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, H. S.; Zhao, J.W.; Zhao, K. X.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. Z.; Zhao, S.J.; Zhao, T.C.; Zhao, X. H.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, Y. H.; Zhong, B.; Zhong, J.; Zhong, Z.; Zhou, L.; Zhou, X. K.; Zhou, X.R.; Zhu, C.; Zhu, K.; Zhu, K. J.; Zhu, S.H.; Zhu, Stuart; Zhu, Y.C.; Zhu, Y.M.; Zhu, Y.S.; Zhu, Z. A.; Zhuang, J.; Zou, B. S.; Zou, J. H.; Werner, M.J.; Zheng, J.P.

    2013-01-01

    Using a data sample of 2.25 x 10(8) J/psi events collected with the BESIII detector, we present the first observation of the decays of eta(c) mesons to Sigma(+)(Sigma) over bar (-) and (sic)(-)(+) .The branching fractions are measured to be (2.11 +/- 0.28(stat) +/- 0.18(syst) +/- 0.50(PDG)) x 10(-3)

  1. Alternative energies; Energies alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Bonal, J.; Rossetti, P

    2007-07-01

    The earth took millions years to made the petroleum, the gas the coal and the uranium. Only a few centuries will be needed to exhaust these fossil fuels and some years to reach expensive prices. Will the wold continue on this way of energy compulsive consumption? The renewable energies and some citizen attitudes are sufficient to break this spiral. This book proposes to discuss these alternative energies. It shows that this attitude must be supported by the government. It takes stock on the more recent information concerning the renewable energies. it develops three main points: the electricity storage, the housing and the transports. (A.L.B.)

  2. BEGA Starter/Alternator - Vector Control Implementation and Performance for Wide Speed Range at Unity Power Factor Operation

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Boldea, Ion; Coroban-Schramel, Vasile;

    2008-01-01

    to infinite. A vector control structure is proposed for BEGA operation during motoring and generating, at unity power factor with zero d-axis current (id) and zero q-axis flux (Ψq) control. In such conditions BEGA behaves like a truly dc. brush machine (with zero reactance in steady state !). A high iq...... current is required in order to cancel the q-axis flux, during unity power factor operation. This engages higher copper losses in the machine. In order to minimize the copper losses, for lower load levels, a current referencer is proposed. Due to higher dc field excitation time constant, the dc field...

  3. Potential applications for sigma receptor ligands in cancer diagnosis and therapy

    NARCIS (Netherlands)

    van Waarde, Aren; Rybczynska, Anna A.; Kuzhuppilly Ramakrishnan, Nisha; Ishiwata, Kiichi; Elsinga, Philip H.; Dierckx, Rudi A. J. O.

    2015-01-01

    Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins. Their endogenous ligands may include the hallucinogen N,N-dimethyltryptamine (DMT) and sphingolipid-derived amines which interact with sigma-1 receptors, besides steroid hormones (e.g., progesterone) which bind to b

  4. Transcription factor-based biosensor

    Science.gov (United States)

    Dietrich, Jeffrey A; Keasling, Jay D

    2013-10-08

    The present invention provides for a system comprising a BmoR transcription factor, a .sigma..sup.54-RNA polymerase, and a pBMO promoter operatively linked to a reporter gene, wherein the pBMO promoter is capable of expression of the reporter gene with an activated form of the BmoR and the .sigma..sup.54-RNA polymerase.

  5. Tensor form factors of the octet hyperons in QCD

    CERN Document Server

    kucukarslan, A; Ozpineci, A

    2016-01-01

    Light-cone QCD sum rules to leading order in QCD are used to investigate the tensor form factors of the $\\Sigma-\\Sigma$, $\\Xi-\\Xi$ and $ \\Sigma-\\Lambda$ transitions in the range $1 GeV^2 \\leq Q^2 \\leq 10 GeV^2$. The DAs of $\\Sigma$, $\\Xi$ and $\\Lambda$ baryon have been calculated without higher order terms. Then, study including higher order corrections have been done for $\\Sigma$ and $\\Lambda$ baryon. The result of form factors are obtained using these two DAs. We make a comparison with the predictions of the chiral quark soliton model.

  6. Alternative additives; Alternative additiver

    Energy Technology Data Exchange (ETDEWEB)

    2007-08-15

    In this project a number of industrial and agricultural waste products have been characterised and evaluated in terms of alkali-getter performance. The intended use is for biomass-fired power stations aiming at reducing corrosion or slagging related problems. The following products have been obtained, characterised and evaluated: 1) Brewery draff 2) Danish de-gassed manure 3) Paper sludge 4) Moulding sand 5) Spent bleaching earth 6) Anorthosite 7) Sand 8) Clay-sludge. Most of the above alternative additive candidates are deemed unsuitable due to insufficient chemical effect and/or expensive requirements for pre-treatment (such as drying and transportation). 3 products were selected for full-scale testing: de-gassed manure, spent bleaching earth and clay slugde. The full scale tests were undertaken at the biomass-fired power stations in Koege, Slagelse and Ensted. Spent bleaching earth (SBE) and clay sludge were the only tested additive candidates that had a proven ability to react with KCl, to thereby reduce Cl-concentrations in deposits, and reduce the deposit flux to superheater tubes. Their performance was shown to nearly as good as commercial additives. De-gassed manure, however, did not evaluate positively due to inhibiting effects of Ca in the manure. Furthermore, de-gassed manure has a high concentration of heavy metals, which imposes a financial burden with regard to proper disposal of the ash by-products. Clay-sludge is a wet clay slurring, and drying and transportation of this product entails substantial costs. Spent bleaching does not require much pre-treatment and is therefore the most promising alternative additive. On the other hand, bleaching earth contains residual plant oil which means that a range of legislation relating to waste combustion comes into play. Not least a waste combustion fee of 330 DKK/tonne. For all alternative (and commercial) additives disposal costs of the increase ash by-products represents a significant cost. This is

  7. Sigma metrics in clinical chemistry laboratory – A guide to quality control

    OpenAIRE

    Usha S. Adiga; A. Preethika; K.Swathi

    2015-01-01

    Background: Six sigma is a process of quality measurement and improvement program used in industries. Sigma methodology can be applied wherever an outcome of a process is to be measured. A poor outcome is counted as an error or defect. This is quantified as defects per million (DPM). Six sigma provides a more quantitative frame work for evaluating process performance with evidence for process improvement and describes how many sigma fit within the tolerance limits. Sigma metrics can be used e...

  8. Alternative splicing isoform of T cell factor 4K suppresses the proliferation and metastasis of non-small cell lung cancer cells.

    Science.gov (United States)

    Fan, Y C; Min, L; Chen, H; Liu, Y L

    2015-10-30

    The Wnt pathway has been implicated in the initiation, progression, and metastasis of lung cancer. T cell factor 4, a member of TCF/LEF family, acts as a transcriptional factor for Wnt pathways in lung cancer. Increasing amounts of evidence have shown that TCF-4 has multiple alternative splicing isoforms with transactivation or transrepression activity toward the Wnt pathway. Here, we found the presence of multiple TCF-4 isoforms in lung cancer cell lines and in normal bronchial epithelial cells. TCF-4K isoform expression was significantly decreased in lung cancer cells compared with normal bronchial epithelial cells and was identified as a transcriptional suppressor of the Wnt pathway in non-small cell lung carcinoma (NSCLC). Overexpression of TCF-4K significantly inhibited the proliferation and migration of NSCLC cells. Collectively, our data indicate that TCF-4K functions as a tumor suppressor in NSCLC by down-regulating the Wnt pathway.

  9. Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus): Molecular and functional characterization and immune responsive mRNA expression analysis.

    Science.gov (United States)

    Godahewa, G I; Perera, N C N; Bathige, S D N K; Nam, Bo-Hye; Noh, Jae Koo; Lee, Jehee

    2016-08-01

    The complement system serves conventional role in the innate defense against common invading pathogens. Complement factor D (CfD) is vital to alternative complement pathway activation in cleaving complement factor B. This catalytic reaction forms the alternative C3 convertase that is crucial for complement-mediated pathogenesis. In this study, rock bream (Oplegnathus fasciatus) CfD (OfCfD) was characterized and OfCfD mRNA expression was investigated. OfCfD encodes 277 amino acids (aa) for a 30-kDa polypeptide. A domain analysis of the deduced OfCfD aa sequence showed a single serine protease trypsin superfamily domain, a serine active region, three active sites, and three substrate-binding sites. Pairwise sequence comparisons indicated that OfCfD has the highest identity (84.5%) with Oreochromis niloticus CfD. The phylogenetic tree revealed a common ancestral origin of CfD members, with fish CfD distinct from other vertebrate orthologs. The structural arrangement of the OfCfD gene (2451 bp) contained five exons interrupted by four introns. A spatial transcriptional analysis indicated that OfCfD transcripts constitutively expressed in all of the examined rock bream tissues, and that they were highest in the spleen and liver. In addition, OfCfD transcripts were immunologically upregulated by lipopolysaccharide (LPS) (12 h p.i.), Streptococcus iniae (12 h p.i.), rock bream iridovirus (RBIV) (6-12 h p.i.), and poly I:C (6 h p.i.) in spleen tissue. OfCfD is a trypsin protease and its recombinant protein showed strong protease activity similar to that of trypsin, indicating its catalytic function in the alternative pathway. Together, our findings suggest that OfCfD might be involved in immune responses in rock bream. PMID:27311435

  10. APLIKASI SIX SIGMA PADA PRODUK CLEAR FILE DI PERUSAHAAN STATIONARY

    Directory of Open Access Journals (Sweden)

    Desy Emilasari

    2007-01-01

    Full Text Available This paper describes the application of the Six Sigma methods is used in order to improve quality in manufacturing company that produce stationary product. DMAIC approach is utilized to analyze and improve 'Pocket Clear File' product since this product has more variability and defects. Quality improvement also monitor the process that influenced pocket defect in Bag Making, Kami-ire, Karidome, and Pocket after Karidome Inspections section. Determining of Six Sigma project is based in process and defect type in each section. FMEA also gave the recommendation for quality improvement we need to evaluate the final result of the improvement since some of them were not working properly. Abstract in Bahasa Indonesia : Paper ini menggambarkan bagaimana aplikasi metode Six Sigma digunakan untuk melakukan perbaikan kualitas pada perusahaan manufaktur yang memproduksi produk stationary. Pendekatan DMAIC dipakai untuk menganalisa dan melakukan perbaikan produk 'Pocket Clear File' karena tingginya variabilitas dan cacat dibanding produk lain. Perbaikan kualitas juga memperhatikan proses yang mempengaruhi terjadinya cacat pocket pada section Bag Making, Kami-ire, Karidome, dan Pocket after Karidome Inspection. Penentuan proyek Six Sigma didasarkan atas proses dan jenis cacat pada setiap section. Pendekatan FMEA mampu memberi rekomendasi perbaikan kualitas. Evaluasi dari hasil perbaikan penting untuk dilakukan karena beberapa implementasi perbaikan kualitas tidak berjalan sesuai dengan rencana. kata kunci: six sigma, DMAIC, perusahaan stationary.

  11. A Lean Six Sigma program in higher education

    KAUST Repository

    Svensson, Carsten

    2015-01-01

    Purpose The objective of this paper is to contribute to the body of Lean Six Sigma knowledge within the field of higher education institutions. The paper will review the initial phase of an implementation and highlight future challenges of applying the Lean Six Sigma method in a complex transactional environment. Design/methodology/approach The observations presented in this paper originate from rolling out a large Lean Six Sigma implementation at a recently established university. The paper is supported with secondary data from literature. Findings The implementation of Lean Six Sigma methodology at King Abdullah University of Science and Technology (KAUST) has resulted in improvements in business processes and efficiency. This has been achieved through project execution and training programs. Approximately 350 staff members have completed awareness training, 50 yellow belts and 150 green belts have been trained, and the first round of seven black belts have completed training of which two have completed certification. Research limitations/implications This paper is based on an empirical study of a single instance and the authors’ experiences as practitioners. Originality/value This paper is the first description of what is believed to be one of the largest implementations of Lean Six Sigma in higher education.

  12. Sistem Informasi Kinerja Layanan Laboratorium Medis dengan Metode Six Sigma

    Directory of Open Access Journals (Sweden)

    Anindita Kusumastuti Dewi

    2016-01-01

    Full Text Available Medical Laboratory currently holds a very important role in medicine. Evaluation of laboratory quality plays a very important to maintain accurate laboratory results. This study aims to design an information system performance based on the same perception of medical laboratory services from customers using Six Sigma methods and frameworks using ServQual questionnaire. Selection of Six Sigma itself is based on this method can measure the extent to which each process deviates from its purpose as well as to reduce the variation of each of the attributes.  Six Sigma DMAIC namely (Define, Measure, Analyze, Improve, Control preferred because the end result will not yield new products, but only improvements on existing processes. The results of this calculation will be presented in the form of a dashboard for easier management in understanding the results of the evaluation. From the system can be obtained an average value of consumer perceptions terhdap performance today is 2,883, consumer expectations on the performance of 3.3768, the gap between the perceptions and expectations of consumers is -0.4936, customer satisfaction will be the performance of the current 85.37%, the value of 423 360 DPMO and sigma value there at the 2.07664 level.   Keywords: Laboratory Performance; Six Sigma; Servqual; Dashboard

  13. Alternative splicing and expression of the insulin-like growth factor (IGF-1) gene in osteoblasts under mechanical stretch

    Institute of Scientific and Technical Information of China (English)

    XIAN Chengyu; WANG Yuanliang; ZHANG Bingbing; TANG Liling; PAN Jun; LUO Yanfeng; JIANG Peng; LI Dajun

    2006-01-01

    Insulin-like growth factor 1 (IGF-1) promotes osteoblasts differentiation and bone formation,and its expression is induced by mechanical stretch,thus IGF-1 has been considered an effector molecule that links mechanical stimulation and local tissue responses. In this study, a mechanical stretching device was designed to apply physiological level static or cyclic stretching stimulation to osteoblasts.Different isoforms of IGF-1 mRNA were amplified by RT-PCR from the cells using respective primers and these amplified products were sequenced. An isoform of IGF-1 splicing product was found to be selectively produced by osteoblasts under stretching stimulation. This IGF-1 isoform had identical sequence with the mechano growth factor (MGF) which was originally identified in muscle cells. Regulations of the expression of the liver-type IGF (L.IGF-1) and MGF in osteoblasts under stretch stimulation were further studied using semi-quantitative RT-PCR.Stretch stimulation was found to promot the expression of IGF-1 (L.IGF-1 and MGF), and for both isoforms expression was more effectively stimulated by cyclic stretch than static stretch. MGF was detected only in osteoblasts subjected to mechanical stretch,suggesting MGF was a stretch sensitive growth factor.Expression of MGF peaked earlier than that of L.IGF-1, which was similar to their regulation in muscie and suggested similar roles of MGF and L.IGF-1in bone as in muscle cells. The functions of MGF and L.IGF-1 in osteoblasts shall be established by further experimental studies.

  14. Social and Cultural Factors Affecting Complementary and Alternative Medicine (CAM Use during Menopause in Sydney and Bologna

    Directory of Open Access Journals (Sweden)

    Corinne van der Sluijs

    2013-01-01

    Full Text Available Background. Previous surveys found CAM use during menopause to be popular. This paper compares the results from two surveys (Sydney and Bologna to examine factors that determine the extent and pattern of CAM use to alleviate menopausal symptoms. Methods. Women, aged 45–65 years, who were symptomatic when transitioning through menopause or asymptomatic but taking menopause-specific treatments, were recruited in Sydney (n=1,296 and Bologna (n=1,106 to complete the same voluntary, anonymous, and self-administered questionnaire. The results were reanalysed using stratified analyses to determine similarities and differences. Results. Demographics of the two cohorts differed significantly. CAM was more popular in Sydney. The most significant determinants of CAM use were the use of CAM for other conditions besides menopause and the severity of vasomotor symptoms. Occupational status was a determinant of CAM use amongst Bologna respondents only. In order to relieve symptoms, Australian and Italian women used different CAM modalities whose effectiveness was generally perceived as good. Conclusion. CAM use is popular amongst menopausal women from Sydney and Bologna. Differences in the patterns of CAM use seem to depend on CAM availability and on the educational level and professional status of users. The complex interaction between market, social, and cultural factors of CAM use seems to be more influential on women’s choice of CAM than the available evidence of their effectiveness.

  15. Linear, Non-Linear and Alternative Algorithms in the Correlation of IEQ Factors with Global Comfort: A Case Study

    Directory of Open Access Journals (Sweden)

    Francesco Fassio

    2014-11-01

    Full Text Available Indoor environmental quality (IEQ factors usually considered in engineering studies, i.e., thermal, acoustical, visual comfort and indoor air quality are individually associated with the occupant satisfaction level on the basis of well-established relationships. On the other hand, the full understanding of how single IEQ factors contribute and interact to determine the overall occupant satisfaction (global comfort is currently an open field of research. The lack of a shared approach in treating the subject depends on many aspects: absence of established protocols for the collection of subjective and objective measurements, the amount of variables to consider and in general the complexity of the technical issues involved. This case study is aimed to perform a comparison between some of the models available, studying the results of a survey conducted with objective and subjective method on a classroom within University of Roma TRE premises. Different models are fitted on the same measured values, allowing comparison between different weighting schemes between IEQ categories obtained with different methods. The critical issues, like differences in the weighting scheme obtained with different IEQ models and the variability of the weighting scheme with respect to the time of exposure of the users in the building, identified during this small scale comfort assessment study, provide the basis for a survey activity on a larger scale, basis for the development of an improved IEQ assessment method.

  16. Yang–Baxter sigma models based on the CYBE

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Takuya, E-mail: takuya.matsumoto@math.nagoya-u.ac.jp [Institute for Advanced Research and Department of Mathematics, Nagoya University, Nagoya 464-8602 (Japan); Yoshida, Kentaroh, E-mail: kyoshida@gauge.scphys.kyoto-u.ac.jp [Department of Physics, Kyoto University, Kyoto 606-8502 (Japan)

    2015-04-15

    It is known that Yang–Baxter sigma models provide a systematic way to study integrable deformations of both principal chiral models and symmetric coset sigma models. In the original proposal and its subsequent development, the deformations have been characterized by classical r-matrices satisfying the modified classical Yang–Baxter equation (mCYBE). In this article, we propose the Yang–Baxter sigma models based on the classical Yang–Baxter equations (CYBE) rather than the mCYBE. This generalization enables us to utilize various kinds of solutions of the CYBE to classify integrable deformations. In particular, it is straightforward to realize partial deformations of the target space without loss of the integrability of the parent theory.

  17. The Application of Six Sigma Method in a Power Plant

    Directory of Open Access Journals (Sweden)

    Zumrut Ecevit Sati

    Full Text Available In the last decade a process improvement technique, known as Six Sigma, is implemented by many pioneers of the industry as an approach used to more productive and increase profits in all business process from production to human resources management, from finance to marketing. The companies would like to keep and improve their position in a daily changing world market while new techniques and concepts are introduced to the global markets every day and this is only possible through continuous improvements and breakthroughs. In this study, it has been presented the six sigma practice of a power plant owned by Enerjisa, a major energy company in Turkey. In order to achieve Six Sigma project targets, quality techniques and statistical techniques (hypothesis testing, design of experiment etc. are used.

  18. A Mathematical Theory of the Gauged Linear Sigma Model

    CERN Document Server

    Fan, Huijun; Ruan, Yongbin

    2015-01-01

    We construct a rigorous mathematical theory of Witten's Gauged Linear Sigma Model (GLSM). Our theory applies to a wide range of examples, including many cases with non-Abelian gauge group. Both the Gromov-Witten theory of a Calabi-Yau complete intersection X and the Landau-Ginzburg dual (FJRW-theory) of X can be expressed as gauged linear sigma models. Furthermore, the Landau-Ginzburg/Calabi-Yau correspondence can be interpreted as a variation of the moment map or a deformation of GIT in the GLSM. This paper focuses primarily on the algebraic theory, while a companion article will treat the analytic theory.

  19. On tachyons, gauged linear sigma models, and flip transitions

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, David R. [Center for Geometry and Theoretical Physics, Duke University, Durham, NC 27708 (United States); Narayan, Krishnan [Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai - 400005 (India)]. E-mail: narayan@theory.tifr.res.in

    2005-02-01

    We study systems of multiple localized closed string tachyons and the phenomena associated with their condensation, in C{sup 3}/Z{sub N} non-supersymmetric noncompact orbifold singularities using gauged linear sigma model constructions, following hep-th/0406039. Our study reveals close connections between the combinatorics of non-supersymmetric flip transitions (between topologically distinct resolutions of the original singularity), the physics of tachyons of different degrees of relevance and the singularity structure of the corresponding residual endpoint geometries. This in turn can be used to study the stability of the phases of gauged linear sigma models and gain qualitative insight into the closed string tachyon potential. (author)

  20. Structural Multi-objective Probabilistic Design for Six Sigma

    Institute of Scientific and Technical Information of China (English)

    LI Yu-qiang; CUI Zhen-shan; CHEN Jun; ZHANG Dong-juan; RUAN Xue-yu

    2007-01-01

    Uncertainties in engineering design may lead to low reliable solutions that also exhibit high sensitivity to uncontrollable variations. In addition, there often exist several conflicting objectives and constraints in various design environments. In order to obtain solutions that are not only "multi-objectively" optimal, but also reliable and robust, a probabilistic optimization method was presented by integrating six sigma philosophy and multi-objective genetic algorithm. With this method, multi-objective genetic algorithm was adopted to obtain the global Pareto solutions, and six sigma method was used to improve the reliability and robustness of those optimal solutions. Two engineering design problems were provided as examples to illustrate the proposed method.

  1. The Present Status on sigma and kappa Meson Properties

    CERN Document Server

    Ishida, M

    2003-01-01

    The recent experimental data of both pipi / Kpi scattering and production processes, suggesting the existence of scalar sigma and kappa mesons, are reviewed. In many pipi /Kpi production processes the direct effects of their productions are observed, while they are, because of chiral symmetry, hidden in scattering processes, and now sigma(500--600) and kappa(800--900) are considered to be confirmed experimentally. The recent criticism on our method of analyses, which is based on the long believed prejudice of universal pipi / Kpi phase through scattering and production amplitudes, is explained not to be valid.

  2. THE STORY OF SIGMA HYPERNUCLEI - A MODERN FABLE.

    Energy Technology Data Exchange (ETDEWEB)

    CHRIEN,R.E.

    1999-02-19

    The reality of {Sigma} hypernuclei has been the subject of intense concern among experimenters and theoreticians for more than 20 years. The possible existence of {Sigma} hypernuclei was first suggested by a pioneering experiment on a {sup 9}Be target at the CERN PS. There were reported to be two narrow ({Gamma} < 8 MeV) peaks in the continuum region. This finding was quite unexpected since the widths of {Sigma} states were believed to be large due to the strong conversion process. It is obvious that if such relatively long-lived systems were confirmed unambiguously by experiment, their masses and widths provide important constraints on the {Sigma}N effective interaction and its relation to the {Lambda}N and NN interactions. Since the {Sigma} carries isospin, the role of isospin and isospin conservation in hadronic reactions could be explored. This report stimulated a number of subsequent experiments at the BNL-AGS and KEK, along with further experiments with a specially created short kaon beam at the CERN PS. Experimental data were reported for different targets at different momenta and at different conditions. Various tagging techniques were employed to suppress backgrounds, but always at the expense of a reduction in statistical quality. Because of problems with resolution and statistics, contradictions among the different sets of data resulted more often in clouding the issues than clarifying them. Thus, up until a few years ago, there was no statistically clear confirmation of this surprising finding. In the last few years, however, a series of definitive experiments has been performed at the BNL-AGS in an effort to resolve the discrepancies and settle the controversy. Besides repeating the initial experiment on Be, a target of {sup 6}Li was run. The earlier stopped kaon data on {sup 4}He was repeated in an in-flight experiment, and the suggestion of a {Sigma} bound state, with virtually pure isospin, confirmed. We now have a better understanding of the role

  3. The effective action approach applied to nuclear chiral sigma model

    International Nuclear Information System (INIS)

    The nuclear chiral sigma model of nuclear matter is considered by means of the Cornwall-Jackiw-tomboulis (CTJ) effective action. The method provides a very general framework for investigating many important problems: chiral symmetry in nuclear medium, energy density of nuclear ground state, nuclear Schwinger-Dyson (SD) equations, etc. It is shown that the SD equations for sigma-omega mixing are actually not present in this formalism. For numerical computation purposes the Hartree-Fock (HF) approximation for ground state energy density is also presented. (author). 26 refs

  4. Brackets, sigma models and integrability of generalized complex structures

    International Nuclear Information System (INIS)

    It is shown how derived brackets naturally arise in sigma-models via Poisson- or antibracket, generalizing a recent observation by Alekseev and Strobl. On the way to a precise formulation of this relation, an explicit coordinate expression for the derived bracket is obtained. The generalized Nijenhuis tensor of generalized complex geometry is shown to coincide up to a de-Rham closed term with the derived bracket of the structure with itself and a new coordinate expression for this tensor is presented. The insight is applied to two known two-dimensional sigma models in a background with generalized complex structure

  5. CMOS sigma-delta converters practical design guide

    CERN Document Server

    De la Rosa, Jose M

    2013-01-01

    A comprehensive overview of Sigma-Delta Analog-to-Digital Converters (ADCs) and a practical guide to their design in nano-scale CMOS for optimal performance. This book presents a systematic and comprehensive compilation of sigma-delta converter operating principles, the new advances in architectures and circuits, design methodologies and practical considerations - going from system-level specifications to silicon integration, packaging and measurements, with emphasis on nanometer CMOS implementation. The book emphasizes practical design issues - from high-level behavioural modelling i

  6. Double Soft Theorems and Shift Symmetry in Nonlinear Sigma Models

    CERN Document Server

    Low, Ian

    2015-01-01

    We show both the leading and subleading double soft theorems of the nonlinear sigma model follow from a shift symmetry enforcing Adler's zero condition in the presence of an unbroken global symmetry. They do not depend on the underlying coset G/H and are universal infrared behaviors of Nambu-Goldstone bosons. Although nonlinear sigma models contain an infinite number of interaction vertices, the double soft limit is determined entirely by a single four-point interaction, together with the existence of Adler's zeros.

  7. Dilaton gravity, Poisson sigma models and loop quantum gravity

    Energy Technology Data Exchange (ETDEWEB)

    Bojowald, Martin; Reyes, Juan D, E-mail: bojowald@gravity.psu.ed, E-mail: jdr234@psu.ed [Institute for Gravitation and the Cosmos, Pennsylvania State University, 104 Davey Lab, University Park, PA 16802 (United States)

    2009-02-07

    Spherically symmetric gravity in Ashtekar variables coupled to Yang-Mills theory in two dimensions and its relation to dilaton gravity and Poisson sigma models are discussed. After introducing its loop quantization, quantum corrections for inverse triad components are shown to provide a consistent deformation without anomalies. The relation to Poisson sigma models provides a covariant action principle of the quantum-corrected theory with effective couplings. Results are also used to provide loop quantizations of spherically symmetric models in arbitrary D spacetime dimensions.

  8. Remarks on the pion-nucleon sigma-term

    CERN Document Server

    Hoferichter, Martin; Kubis, Bastian; Meißner, Ulf-G

    2016-01-01

    The pion-nucleon $\\sigma$-term can be stringently constrained by the combination of analyticity, unitarity, and crossing symmetry with phenomenological information on the pion-nucleon scattering lengths. Recently, lattice calculations at the physical point have been reported that find lower values by about $3\\sigma$ with respect to the phenomenological determination. We point out that a lattice measurement of the pion-nucleon scattering lengths could help resolve the situation by testing the values extracted from spectroscopy measurements in pionic atoms.

  9. A lattice determination of Sigma-Lambda mixing

    Energy Technology Data Exchange (ETDEWEB)

    Horsley, R. [Edinburgh Univ. (United Kingdom). School of Physics and Astronomy; Najjar, J. [Regensburg Univ. (Germany). Institut fuer Theoretische Physik; Nakamura, Y. [RIKEN Advanced Institute for Computational Science, Kobe (Japan); Perlt, H.; Schiller, A. [Leipzig Univ. (Germany). Inst. fuer Theoretische Physik; Pleiter, D. [Forschungszentrum Juelich (Germany). Juelich Supercomputer Centre; Rakow, P.E.L. [Liverpool Univ. (United Kingdom). Theoretical Physics Division; Schierholz, G. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Stueben, H. [Hamburg Univ. (Germany). Regionales Rechenzentrum; Zanotti, J.M. [Adelaide Univ. (Australia). CSSM, Dept. of Physics; Collaboration: QCDSF-UKQCD Collaboration

    2014-11-15

    Isospin breaking effects in baryon octet (and decuplet) masses are due to a combination of up and down quark mass differences and electromagnetic effects and lead to small mass splittings. Between the Sigma and Lambda this mass splitting is much larger, this being mostly due to their different wavefunctions. However when isospin is broken, there is a mixing between between these states. We describe the formalism necessary to determine the QCD mixing matrix and hence find the mixing angle and mass splitting between the Sigma and Lambda particles due to QCD effects.

  10. Added value in health care with six sigma.

    Science.gov (United States)

    Lenaz, Maria P

    2004-06-01

    Six sigma is the structured application of the tools and techniques of quality management applied on a project basis that can enable organizations to achieve superior performance and strategic business results. The Greek character sigma has been used as a statistical term that measures how much a process varies from perfection, based on the number of defects per million units. Health care organizations using this model proceed from the lower levels of quality performance to the highest level, in which the process is nearly error free.

  11. The light scalars and the broad $\\sigma (500)$ in the U3xU3 linear sigma model

    CERN Document Server

    Törnqvist, N A

    2000-01-01

    The lightest scalar and pseudoscalar nonets are discussed within the [A framework of the broken old UxU3 linear sigma model, and it is shown that already at the tree level this model works remarkably well predicting scalar masses and couplings not far from present experimental values, when all parameters are fixed from the pseudoscalar masses and decay constants. The linear sigma model is the simplest way to implement chiral symmetry together with the broken SU3 of the quark model, and this, not well known, success in understanding experiment is comparable to that of the naive quark model for the heavier multiplets. It is argued that this strongly suggest that the light and very broad sigma resonance exists near 500 MeV.

  12. Evaluation of Expenditure Alternates

    Science.gov (United States)

    Poehlein, Gary W.; And Others

    1973-01-01

    Illustrates a system of calculating dollar expenditures over periods of time in terms of present value. The system enables planners, school boards, and administrators to compare expenditure alternatives as a decisionmaking factor. (Author)

  13. Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells

    DEFF Research Database (Denmark)

    Ortis, Fernanda; Naamane, Najib; Flamez, Daisy;

    2010-01-01

    OBJECTIVE: Cytokines contribute to pancreatic beta-cell death in type 1 diabetes. This effect is mediated by complex gene networks that remain to be characterized. We presently utilized array analysis to define the global expression pattern of genes, including spliced variants, modified...... of genes involved in the maintenance of beta-cell phenotype and growth/regeneration. Cytokines induced hypoxia-inducible factor-alpha, which in this context has a proapoptotic role. Cytokines also modified the expression of >20 genes involved in RNA splicing, and exon array analysis showed cytokine......-induced changes in alternative splicing of >50% of the cytokine-modified genes. CONCLUSIONS: The present study doubles the number of known genes expressed in primary beta-cells, modified or not by cytokines, and indicates the biological role for several novel cytokine-modified pathways in beta-cells. It also...

  14. Cosmological constraints from the cluster contribution to the power spectrum of the soft X-ray background. New evidence for a low sigma_8

    CERN Document Server

    Diego-Rodriguez, J M; Silk, J; Barcons, X; Voges, W

    2003-01-01

    We use the X-ray power spectrum of the ROSAT all-sky survey in the R6 band (approximately 0.9-1.3 keV) to set an upper limit on the galaxy cluster power spectrum. The cluster power spectrum is modelled with a minimum number of robust assumptions regarding the structure of the clusters. The power spectrum of ROSAT sets an upper limit on the Omega_m-sigma_8 plane which excludes all the models with sigma_8 above sigma_8 = 0.5/(Omega_m^0.38) in a flat LCDM universe. We discuss the possible sources of systematic errors in our conclusions, mainly dominated by the assumed L_x-T relation. Alternatively, this relation could be constrained by using the X-ray power spectrum, if the cosmological model is known. Our conclusions suggest that only models with a low value of sigma_8 (sigma_8 < 0.8 for Omega_m = 0.3) may be compatible with our upper limit. We also find that models predicting lower luminosities in galaxy clusters are favoured. Reconciling our cosmological constraints with these arising by other methods migh...

  15. Generic Lean Six Sigma project definitions in financial services

    NARCIS (Netherlands)

    H. de Koning; J. de Mast; R.J.M.M. Does; T. Vermaat; S. Simons

    2008-01-01

    Lean Six Sigma (LSS) is applied in financial service organizations to improve operational efficiency and effectiveness. LSS prescribes that these improvements are designed and implemented by projects. The purpose of this article is to facilitate the process of defining LSS projects in finance, becau

  16. Three-body system of $\\pi \\pi \\Sigma_c$

    CERN Document Server

    Long, Bingwei

    2016-01-01

    The existence of near-threshold charmed baryon $\\Lambda_c^+(2595)$ implies the pion and the lightest, isospin-$1$ charmed baryon $\\Sigma_c$ interact very strongly at extremely low energies. Using the two-flavor version of heavy hadron chiral perturbation theory, I explore the direct consequences of this strong force by investigating whether the $\\Sigma_c$ can trap two very soft pions to form any visible hadronic states. The answer is positive. It is found without tuning any free parameters or ultraviolet cutoff that the state in question, with quantum numbers $I(J^P) = 1({\\frac{1}{2}}^+)$, presents itself as a resonance pole only a few MeVs away from the $\\pi \\pi \\Sigma_c$ threshold. Subleading corrections are estimated with power-counting arguments, and the smallness of pion momenta is found to facilitate the reliability of the analysis. Because of its proximity in mass, this excited $\\Sigma_c$ resonance is speculated to be related to the broad resonance labeled as $\\Lambda_c^+(2765)$.

  17. The Moduli Space in the Gauged Linear Sigma Model

    CERN Document Server

    Fan, Huijun; Ruan, Yongbin

    2016-01-01

    This is a survey article for the mathematical theory of Witten's Gauged Linear Sigma Model, as developed recently by the authors. Instead of developing the theory in the most general setting, in this paper we focus on the description of the moduli.

  18. SIGMA Release v1.2 - Capabilities, Enhancements and Fixes

    Energy Technology Data Exchange (ETDEWEB)

    Mahadevan, Vijay [Argonne National Lab. (ANL), Argonne, IL (United States); Grindeanu, Iulian R. [Argonne National Lab. (ANL), Argonne, IL (United States); Ray, Navamita [Argonne National Lab. (ANL), Argonne, IL (United States); Jain, Rajeev [Argonne National Lab. (ANL), Argonne, IL (United States); Wu, Danqing [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-30

    In this report, we present details on SIGMA toolkit along with its component structure, capabilities, and feature additions in FY15, release cycles, and continuous integration process. These software processes along with updated documentation are imperative to successfully integrate and utilize in several applications including the SHARP coupled analysis toolkit for reactor core systems funded under the NEAMS DOE-NE program.

  19. Beam asymmetry $\\Sigma$ measurements on the $\\pi^-$ photoproduction off neutrons

    CERN Document Server

    Mandaglio, G; Manganaro, M; Bellini, V; Bocquet, J P; Casano, L; D'Angelo, A; Di Salvo, R; Fantini, A; Franco, D; Gervino, G; Ghio, F; Giardina, G; Girolami, B; Giusa, A; Ignatov, A; Lapik, A; Sandri, P Levi; Lleres, A; Moricciani, D; Mushkarenkov, A N; Nedorezov, V; Randieri, C; Rebreyend, D; Rudnev, N V; Russo, G; Schaerf, C; Sperduto, M L; Sutera, M C; Turinge, A; Vegna, V; Briscoe, W J; Strakovsky, I I

    2010-01-01

    The $\\Sigma$ beam asymmetry in the photoproduction of negative pions from quasi-free neutrons in a deuterium target was measured at Graal in the energy interval 700 - 1500 MeV and a wide angular range, using polarized and tagged photons. The results are compared with recent partial wave analyses.

  20. Inter-industry generic Lean Six Sigma project definitions

    NARCIS (Netherlands)

    B.A. Lameijer; R.J.M.M. Does; J. de Mast

    2016-01-01

    Purpose - The objective of this research is to provide practitioners with inter-industry applicable rules and guidelines for the Lean Six Sigma (LSS) project definition phase. This research resulted in 13 inter-industry generic project definitions that are divided by four performance dimensions: qua

  1. Generic Lean Six Sigma project definitions in publishing

    NARCIS (Netherlands)

    H. de Koning; R.J.M.M. Does; A. Groen; B.P.H. Kemper

    2010-01-01

    Purpose - Many companies in the publishing industry are facing the task of developing new business models and becoming more efficient and effective in execution. Lean Six Sigma (LSS) is a unified framework for systematically developing efficiency and quality improvements; it can help realize signifi

  2. On the morphology of sigma-drop galaxies

    CERN Document Server

    Comerón, S; Beckman, J E

    2008-01-01

    Context: Local reductions of the stellar velocity dispersion in the central regions of galaxies are known as sigma-drops. Knowing the origin of these features can lead to better understanding of inner galactic dynamics. Aims: We present a sample of 20 sigma-drop galaxies matched with a control sample of galaxies without sigma-drop in order to search for correlations between sigma-drops and the properties, primarily morphological, of the nuclear zones and discs of their host galaxies. Methods: We study the dust and Halpha distribution at 0.1 arcsec scale, using Hubble Space Telescope imaging, in the circumnuclear zones of the two samples of galaxies, searching for differences and trying to establish a link between the nuclear kinematics and the host morphology. We have also considered the CO and HI emission of the galaxies and their luminosity profiles. Results: We classify the two samples following both morphological parameters and the luminosity profiles. We find a larger fraction of nuclear dust spirals and...

  3. D-Dimensional Conformal $\\sigma$-models and Topological Excitations

    CERN Document Server

    Bulgadaev, S A

    2000-01-01

    The D-dimensional conformal nonlinear sigma-models (NSM) sre constructed. Itis shown that the NSM on spaces with $\\pi_{D-1} = \\mathbb {Z}$ have thetopological solutions of a "hedgehog" and "anti-hedgehog" types withlogarithmic energies. For spaces with $\\pi_D \

  4. Nucleon Properties from Approximating Chiral Quark Sigma Model

    CERN Document Server

    Abu-Shady, M

    2009-01-01

    We apply the approximating chiral quark model. This chiral quark model is based on an effective Lagrangian which the interactions between quarks via sigma and pions mesons. The field equations have been solved in the mean field approximation for the hedgehog baryon state. Good results are obtained for nucleon properties in comparison with original model.

  5. Classical solutions of a flag manifold sigma-model

    CERN Document Server

    Bykov, Dmitri

    2015-01-01

    We study a sigma-model with target space the flag manifold U(3)/U(1)^3. A peculiarity of the model is that the complex structure on the target space enters explicitly in the action. We describe the classical solutions of the model for the case when the worldsheet is a sphere CP^1.

  6. Thermodynamics of O(N) sigma models : 1/N corrections

    NARCIS (Netherlands)

    Andersen, JO; Boer, D; Warringa, HJ

    2004-01-01

    The thermodynamics of the O(N) linear and nonlinear sigma models in 3+1 dimensions is studied. We calculate the pressure to next-to-leading order in the 1/N expansion and show that at this order, temperature-independent renormalization is only possible at the minimum of the effective potential. The

  7. Why all this fuss over a few Sigma ?

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Sigma, the standard deviation, is the quantity used most often by physicists to express the strength of evidence for a new phenomenon. It is the way they measure the distance between the data observed and the data expected if there were no new phenomenon. What that means is best understood by taking a more familiar example : toss a fair coin (See Bulletin)

  8. Applying Lean and Six Sigma in financial service

    NARCIS (Netherlands)

    R.J.M.M. Does; H. de Koning

    2006-01-01

    Abstract Lean and Six Sigma have gone through parallel developments in recent years. Originally applied to a small range of industries, both approaches are now also used widely in healthcare, administration and service. A recent development is the integration of the two approaches. In this paper we

  9. Reply to "Comment on `Lattice determination of Sigma - Lambda mixing' "

    CERN Document Server

    Horsley, R; Nakamura, Y; Perlt, H; Pleiter, D; Rakow, P E L; Schierholz, G; Schiller, A; Stüben, H; Zanotti, J M

    2015-01-01

    In this Reply, we respond to the above Comment. Our computation [Phys. Rev. D 91 (2015) 074512] only took into account pure QCD effects, arising from quark mass differences, so it is not surprising that there are discrepancies in isospin splittings and in the Sigma - Lambda mixing angle. We expect that these discrepancies will be smaller in a full calculation incorporating QED effects.

  10. Gustav Naan ja Sigma Tau / Arvo Pesti, Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Arvo, 1956-2010

    2009-01-01

    Füüsik, kosmoloog ja ühiskonnategelane Gustav Naanist. Merle Karusoo dokumentaallavastusest "Sigma Tau-C705", mis põhineb Enn Vetemaa ja Erki Aule näidendil "Gustav Naani hiilgus ja viletsus". Esietendus 16. märtsil 2008 Eesti Draamateatris

  11. A rational reconstruction of Six Sigma's Breakthrough Cookbook

    NARCIS (Netherlands)

    H. de Koning; J. de Mast

    2006-01-01

    Purpose: The purpose of this paper is to develop a consistent and crystallized exposition of Six-Sigma's methodology for improvement projects, which could serve as a basis for subsequent scientific research of the method. Design/methodology/approach: The paper shows that reformulation of imprecise a

  12. HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages

    Directory of Open Access Journals (Sweden)

    Purcell Damian FJ

    2008-02-01

    Full Text Available Abstract Background Macrophages are important targets and long-lived reservoirs of HIV-1, which are not cleared of infection by currently available treatments. In the primary monocyte-derived macrophage model of infection, replication is initially productive followed by a decline in virion output over ensuing weeks, coincident with a decrease in the levels of the essential viral transactivator protein Tat. We investigated two possible mechanisms in macrophages for regulation of viral replication, which appears to be primarily regulated at the level of tat mRNA: 1 differential mRNA stability, used by cells and some viruses for the rapid regulation of gene expression and 2 control of HIV-1 alternative splicing, which is essential for optimal viral replication. Results Following termination of transcription at increasing times after infection in macrophages, we found that tat mRNA did indeed decay more rapidly than rev or nef mRNA, but with similar kinetics throughout infection. In addition, tat mRNA decayed at least as rapidly in peripheral blood lymphocytes. Expression of cellular splicing factors in uninfected and infected macrophage cultures from the same donor showed an inverse pattern over time between enhancing factors (members of the SR family of RNA binding proteins and inhibitory factors (members of the hnRNP family. While levels of the SR protein SC35 were greatly up-regulated in the first week or two after infection, hnRNPs of the A/B and H groups were down-regulated. Around the peak of virus production in each culture, SC35 expression declined to levels in uninfected cells or lower, while the hnRNPs increased to control levels or above. We also found evidence for increased cytoplasmic expression of SC35 following long-term infection. Conclusion While no evidence of differential regulation of tat mRNA decay was found in macrophages following HIV-1 infection, changes in the balance of cellular splicing factors which regulate alternative

  13. MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.

    Science.gov (United States)

    Okuyama, Kazuki; Ikawa, Tomokatsu; Gentner, Bernhard; Hozumi, Katsuto; Harnprasopwat, Ratanakanit; Lu, Jun; Yamashita, Riu; Ha, Daon; Toyoshima, Takae; Chanda, Bidisha; Kawamata, Toyotaka; Yokoyama, Kazuaki; Wang, Shusheng; Ando, Kiyoshi; Lodish, Harvey F; Tojo, Arinobu; Kawamoto, Hiroshi; Kotani, Ai

    2013-08-13

    Lineage specification is thought to be largely regulated at the level of transcription, where lineage-specific transcription factors drive specific cell fates. MicroRNAs (miR), vital to many cell functions, act posttranscriptionally to decrease the expression of target mRNAs. MLL-AF4 acute lymphocytic leukemia exhibits both myeloid and B-cell surface markers, suggesting that the transformed cells are B-cell myeloid progenitor cells. Through gain- and loss-of-function experiments, we demonstrated that microRNA 126 (miR-126) drives B-cell myeloid biphenotypic leukemia differentiation toward B cells without changing expression of E2A immunoglobulin enhancer-binding factor E12/E47 (E2A), early B-cell factor 1 (EBF1), or paired box protein 5, which are critical transcription factors in B-lymphopoiesis. Similar induction of B-cell differentiation by miR-126 was observed in normal hematopoietic cells in vitro and in vivo in uncommitted murine c-Kit(+)Sca1(+)Lineage(-) cells, with insulin regulatory subunit-1 acting as a target of miR-126. Importantly, in EBF1-deficient hematopoietic progenitor cells, which fail to differentiate into B cells, miR-126 significantly up-regulated B220, and induced the expression of B-cell genes, including recombination activating genes-1/2 and CD79a/b. These data suggest that miR-126 can at least partly rescue B-cell development independently of EBF1. These experiments show that miR-126 regulates myeloid vs. B-cell fate through an alternative machinery, establishing the critical role of miRNAs in the lineage specification of multipotent mammalian cells.

  14. Study of $\\psi$ decays to the $\\Xi^{-}\\bar\\Xi^{+}$ and $\\Sigma(1385)^{\\mp}\\bar\\Sigma(1385)^{\\pm}$ final states

    CERN Document Server

    Ablikim, M; Ai, X C; Albayrak, O; Albrecht, M; Ambrose, D J; Amoroso, A; An, F F; An, Q; Bai, J Z; Ferroli, R Baldini; Ban, Y; Bennett, D W; Bennett, J V; Bertani, M; Bettoni, D; Bian, J M; Bianchi, F; Boger, E; Boyko, I; Briere, R A; Cai, H; Cai, X; Cakir, O; Calcaterra, A; Cao, G F; Cetin, S A; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, H Y; Chen, J C; Chen, M L; Chen, S J; Chen, X; Chen, X R; Chen, Y B; Cheng, H P; Chu, X K; Cibinetto, G; Dai, H L; Dai, J P; Dbeyssi, A; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; De Mori, F; Ding, Y; Dong, C; Dong, J; Dong, L Y; Dong, M Y; Dou, Z L; Du, S X; Duan, P F; Fan, J Z; Fang, J; Fang, S S; Fang, X; Fang, Y; Farinelli, R; Fava, L; Fedorov, O; Feldbauer, F; Felici, G; Feng, C Q; Fioravanti, E; Fritsch, M; Fu, C D; Gao, Q; Gao, X L; Gao, X Y; Gao, Y; Gao, Z; Garzia, I; Goetzen, K; Gong, L; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, Y; Guo, Y P; Haddadi, Z; Hafner, A; Han, S; Hao, X Q; Harris, F A; He, K L; Held, T; Heng, Y K; Hou, Z L; Hu, C; Hu, H M; Hu, J F; Hu, T; Hu, Y; Huang, G S; Huang, J S; Huang, X T; Huang, Y; Hussain, T; Ji, Q; Ji, Q P; Ji, X B; Ji, X L; Jiang, L W; Jiang, X S; Jiang, X Y; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Johansson, T; Julin, A; Kalantar-Nayestanaki, N; Kang, X L; Kang, X S; Kavatsyuk, M; Ke, B C; Kiese, P; Kliemt, R; Kloss, B; Kolcu, O B; Kopf, B; Kornicer, M; Kupsc, A; Kühn, W; Lange, J S; Lara, M; Larin, P; Leng, C; Li, C; Li, Cheng; Li, D M; Li, F; Li, F Y; Li, G; Li, H B; Li, J C; Li, Jin; Li, K; Li, Lei; Li, P R; Li, Q Y; Li, T; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Lin, D X; Liu, B J; Liu, C X; Liu, D; Liu, F H; Liu, Fang; Liu, Feng; Liu, H B; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, J Y; Liu, K; Liu, K Y; Liu, L D; Liu, P L; Liu, Q; Liu, S B; Liu, X; Liu, Y B; Liu, Z A; Liu, Zhiqing; Loehner, H; Lou, X C; Lu, H J; Lu, J G; Lu, Y; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lyu, X R; Ma, F C; Ma, H L; Ma, L L; Ma, Q M; Ma, T; Ma, X N; Ma, X Y; Ma, Y M; Maas, F E; Maggiora, M; Mao, Y J; Mao, Z P; Marcello, S; Messchendorp, J G; Min, J; Mitchell, R E; Mo, X H; Mo, Y J; Morales, C; Muchnoi, N Yu; Muramatsu, H; Nefedov, Y; Nerling, F; Nikolaev, I B; Ning, Z; Nisar, S; Niu, S L; Niu, X Y; Olsen, S L; Ouyang, Q; Pacetti, S; Pan, Y; Patteri, P; Pelizaeus, M; Peng, H P; Peters, K; Pettersson, J; Ping, J L; Ping, R G; Poling, R; Prasad, V; Qi, H R; Qi, M; Qian, S; Qiao, C F; Qin, L Q; Qin, N; Qin, X S; Qin, Z H; Qiu, J F; Rashid, K H; Redmer, C F; Ripka, M; Rong, G; Rosner, Ch; Ruan, X D; Santoro, V; Sarantsev, A; Savrié, M; Schoenning, K; Schumann, S; Shan, W; Shao, M; Shen, C P; Shen, P X; Shen, X Y; Sheng, H Y; Song, W M; Song, X Y; Sosio, S; Spataro, S; Sun, G X; Sun, J F; Sun, S S; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Tapan, I; Thorndike, E H; Tiemens, M; Ullrich, M; Uman, I; Varner, G S; Wang, B; Wang, B L; Wang, D; Wang, D Y; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, S G; Wang, W; Wang, W P; Wang, X F; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z H; Wang, Z Y; Weber, T; Wei, D H; Wei, J B; Weidenkaff, P; Wen, S P; Wiedner, U; Wolke, M; Wu, L H; Wu, Z; Xia, L; Xia, L G; Xia, Y; Xiao, D; Xiao, H; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, L; Xu, Q J; Xu, Q N; Xu, X P; Yan, L; Yan, W B; Yan, W C; Yan, Y H; Yang, H J; Yang, H X; Yang, L; Yang, Y X; Ye, M; Ye, M H; Yin, J H; Yu, B X; Yu, C X; Yu, J S; Yuan, C Z; Yuan, W L; Yuan, Y; Yuncu, A; Zafar, A A; Zallo, A; Zeng, Y; Zeng, Z; Zhang, B X; Zhang, B Y; Zhang, C; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J J; Zhang, J L; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, K; Zhang, L; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y N; Zhang, Y T; Zhang, Yu; Zhang, Z H; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, J W; Zhao, J Y; Zhao, J Z; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, Q W; Zhao, S J; Zhao, T C; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, W J; Zheng, Y H; Zhong, B; Zhou, L; Zhou, X; Zhou, X K; Zhou, X R; Zhou, X Y; Zhu, K; Zhu, K J; Zhu, S; Zhu, S H; Zhu, X L; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, J; Zotti, L; Zou, B S; Zou, J H

    2016-01-01

    We study the decays of the charmonium resonances $J/\\psi$ and $\\psi(3686)$ to the final states $\\Xi^{-}\\bar\\Xi^{+}$, $\\Sigma(1385)^{\\mp}\\bar\\Sigma(1385)^{\\pm}$ based on a single baryon tag method using data samples of $(223.7 \\pm 1.4) \\times 10^{6}$ $J/\\psi$ and $(106.4 \\pm 0.9) \\times 10^{6}$ $\\psi(3686)$ events collected with the BESIII detector at the BEPCII collider. The decay $\\psi(3686)\\rightarrow\\Sigma(1385)^{\\mp}\\bar\\Sigma(1385)^{\\pm}$ is observed for the first time, and the measurements of the other processes, including the branching fractions and angular distributions, are in good agreement with and much more precise than the previously published results. Additionally, the ratios $\\frac{{\\cal{B}}(\\psi(3686)\\rightarrow\\Xi^{-}\\bar\\Xi^{+})}{{\\cal{B}}(J/\\psi\\rightarrow\\Xi^{-}\\bar\\Xi^{+})}$, $\\frac{{\\cal{B}}(\\psi(3686)\\rightarrow\\Sigma(1385)^{-}\\bar\\Sigma(1385)^{+})}{{\\cal{B}}(J/\\psi\\rightarrow\\Sigma(1385)^{-}\\bar\\Sigma(1385)^{+})}$ and $\\frac{{\\cal{B}}(\\psi(3686)\\rightarrow\\Sigma(1385)^{+}\\bar\\Sigma(138...

  15. The effects of modified alternate-day fasting diet on weight loss and CAD risk factors in overweight and obese women

    Directory of Open Access Journals (Sweden)

    Eshghinia Samira

    2013-01-01

    Full Text Available Abstract Background Obesity is a worldwide health problem with increasing prevalence. Decrease in energy intake has been shown to lower the risk of coronary artery disease in obese subjects. The common form of dietary restriction is daily calorie restriction (CR. Another form is alternate-day fasting (ADF. This study examined the ability of modified ADF to facilitate weight loss and lower cardiovascular risk factors in overweight and obese women. Methods 15 adult subjects completed an 8 weeks trial (2 weeks observed and 6 weeks ADF. All women consumed very low calorie diet on the fast day and usually diet in every other day. Body weight (BW, fat mass and blood pressure (BP were measured. Fasting blood samples were collected at the first and 57th day of trial for biochemical analysis. Results During the course of the trial, BW of the subjects decreased (p Conclusion These finding suggest that short time ADF is a viable dietary option to help obese individuals lose weight and decrease some CAD risk factors. More and longer-term studies in human subjects are needed to support this important result.

  16. MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked.

    Science.gov (United States)

    Dobó, József; Szakács, Dávid; Oroszlán, Gábor; Kortvely, Elod; Kiss, Bence; Boros, Eszter; Szász, Róbert; Závodszky, Péter; Gál, Péter; Pál, Gábor

    2016-01-01

    MASP-3 was discovered 15 years ago as the third mannan-binding lectin (MBL)-associated serine protease of the complement lectin pathway. Lacking any verified substrate its role remained ambiguous. MASP-3 was shown to compete with a key lectin pathway enzyme MASP-2 for MBL binding, and was therefore considered to be a negative complement regulator. Later, knock-out mice experiments suggested that MASP-1 and/or MASP-3 play important roles in complement pro-factor D (pro-FD) maturation. However, studies on a MASP-1/MASP-3-deficient human patient produced contradicting results. In normal resting blood unperturbed by ongoing coagulation or complement activation, factor D is present predominantly in its active form, suggesting that resting blood contains at least one pro-FD activating proteinase that is not a direct initiator of coagulation or complement activation. We have recently showed that all three MASPs can activate pro-FD in vitro. In resting blood, however, using our previously evolved MASP-1 and MASP-2 inhibitors we proved that neither MASP-1 nor MASP-2 activates pro-FD. Other plasma proteinases, particularly MASP-3, remained candidates for that function. For this study we evolved a specific MASP-3 inhibitor and unambiguously proved that activated MASP-3 is the exclusive pro-FD activator in resting blood, which demonstrates a fundamental link between the lectin and alternative pathways. PMID:27535802

  17. Identification and functional analysis of porcine basic helix-loop-helix transcriptional factor 3 (TCF3) and its alternative splicing isoforms.

    Science.gov (United States)

    Yang, Fan; Wang, Ning; Liu, Yajun; Wang, Huayan

    2016-04-01

    The transcription factor 3 (TCF3) is a basic helix-loop-helix transcription factor and is essential for lymphocyte development and epithelial-mesenchymal transition. The splicing isoform, genomic organization and physiological roles of TCF3 have not been elucidated well in pig. Based on RNA-seq database, four alternative splicing isoforms were identified. Splicing isoforms TCF3(E12), TCF3(E47), and TCF3A expressed globally in porcine tissues, but TCF3B mainly expressed in spleen and endoderm derived tissues, such as pancreas and lung. The functional analysis showed that TCF3(E12), TCF3(E47), and TCF3B were translocated exclusively into nuclei, yet TCF3A was distributed in cytoplasm. The investigation of clinical specimens showed that TCF3 expression was significantly reduced in spleen tissues that were infected by classical swine fever virus (CSFV). This study is for the first time to report two novel splicing isoforms TCF3A and TCF3B, which may play an important role in lymphocyte maturation and have the correlation with CSFV evasion. PMID:27033898

  18. Contributions of Two-Component Regulatory Systems, Alternative σ Factors, and Negative Regulators to Listeria monocytogenes Cold Adaptation and Cold Growth

    Science.gov (United States)

    Chan, Yvonne C.; Hu, Yuewei; Chaturongakul, Soraya; Files, Kali D.; Bowen, Barbara M.; Boor, Kathryn J.; Wiedmann, Martin

    2011-01-01

    The ability of Listeria monocytogenes to grow at refrigeration temperatures is critical for transmission of this foodborne pathogen. We evaluated the contributions of different transcriptional regulators and two-component regulatory systems to L. monocytogenes cold adaptation and cold growth. L. monocytogenes parent strain 10403S and selected isogenic null mutants in genes encoding four alternative σ factors (sigB, sigH, sigC, and sigL), two regulators of σB (rsbT and rsbV), two negative regulators (ctsR and hrcA), and 15 two-component response regulators were grown in brain heart infusion broth at 4°C with (i) a high-concentration starting inoculum (108 CFU/ml), (ii) a low-concentration starting inoculum (102 CFU/ml), and (iii) a high-concentration starting inoculum of cold-adapted cells. With a starting inoculum of 108 CFU/ml, null mutants in genes encoding selected alternative σ factors (ΔsigH, ΔsigC, and ΔsigL), a negative regulator (ΔctsR), regulators of σB (ΔrsbT and ΔrsbV), and selected two-component response regulators (ΔlisR, Δlmo1172, and Δlmo1060) had significantly reduced growth (P < 0.05) compared with the parent strain after 12 days at 4°C. The growth defect for ΔsigL was limited and was not confirmed by optical density (OD600) measurement data. With a starting inoculum of 102 CFU/ml and after monitoring growth at 4°C over 84 days, only the ΔctsR strain had a consistent but limited growth defect; the other mutant strains had either no growth defects or limited growth defects apparent at only one or two of the nine sampling points evaluated during the 84-day growth period (ΔsigB, ΔsigC, and Δlmo1172). With a 108 CFU/ml starting inoculum of cold-adapted cells, none of the mutant strains that had a growth defect when inoculation was performed with cells pregrown at 37°C had reduced growth as compared with the parent strain after 12 days at 4°C, suggesting a specific defect in the ability of these mutant strains to adapt to 4

  19. Six Sigma: not for the faint of heart.

    Science.gov (United States)

    Benedetto, Anthony R

    2003-01-01

    Six Sigma is an excellent quality and performance improvement tool. Like any tool, the results of using it are highly dependent on whether you use it with competence and on the right problem. This article will help you decide if your problem is well-suited for a Six Sigma approach and will suggest the optimum approach for planning and implementing Six Sigma methodology. Performance improvement methods can be grouped into two broad categories, based on the problem to be addressed. When the problem is relatively minor and localized, "evolutionary" methods may be suitable (e.g., quality circles, problem-solving staff meetings, continuous quality improvement [CQI], total quality management [TQM]). These tools work best when modest incremental improvements are sought, when major process redesign is not thought to be necessary, and when the avoidance of workplace disruption is desired. Reengineering and Six Sigma are the best-known examples of the "revolutionary" performance improvement methods. These methods should be used when major (drastic, do or die, etc.) improvements are needed. Problems that cross departmental boundaries need these methods. When a process is so dysfunctional that you feel like you need to tear up the standard operating procedure (SOP) and start all over again, you need a revolutionary method. A Six Sigma project requires a major expenditure of money and employee time, and a willingness to make some hard decisions about jobs, employee retention and relationships among stakeholders. An institution's culture should be considered as part of the decision about using Six Sigma. If the institution has a history of making data-driven decisions, or at least has displayed openness to operating in that manner, Six Sigma has a good chance of success. A radiology-driven Six Sigma project should not be undertaken until a comprehensive written description of the scope of the project is approved by the radiology department leadership team and by the appropriate

  20. DEPLOYMENT OF SIX SIGMA METHODOLOGY TO REDUCE COMPLICATIONS IN INTRAVITREAL INJECTIONS

    Directory of Open Access Journals (Sweden)

    İbrahim SAHBAZ

    2014-04-01

    Full Text Available The purpose of this study is to show how a private eye care center in Turkey initiated Six Sigma principles to reduce the number of complications encountered during and after intravitreal injections. Data were collected for 30-months. To analyse the complications among 229 injections administered on 106 patients, main tools of Six Sigma’s Define-Measure-Analyze-Improve-Control (DMAIC improvement cycle such as SIPOC table, Fishbone Diagram and, Failure, Mode and Effect Analysis were implemented. Sources and root causes of seven types of complications were identified and reported. For a successful intravitreal injection, experience of the retina specialist, attention of the retina specialist and patient’s ocular pathology were determined to be the “critical few” factors whereas, sterilization and hygiene, dosage of drug/agent and chemical properties of drug/agent were found to be the “trivial many”factors. The most frequently occuring and the complication with the highest hazard score was found to be subconjunctival haemorrhage. The process sigma level of the process was measured to be 3.2657. The surgical team concluded that six of the complications (out of seven should be significantly reduced by taking the necessary preventative measures.

  1. Fox-2 Splicing Factor Binds to a Conserved Intron Motif to PromoteInclusion of Protein 4.1R Alternative Exon 16

    Energy Technology Data Exchange (ETDEWEB)

    Ponthier, Julie L.; Schluepen, Christina; Chen, Weiguo; Lersch,Robert A.; Gee, Sherry L.; Hou, Victor C.; Lo, Annie J.; Short, Sarah A.; Chasis, Joel A.; Winkelmann, John C.; Conboy, John G.

    2006-03-01

    Activation of protein 4.1R exon 16 (E16) inclusion during erythropoiesis represents a physiologically important splicing switch that increases 4.1R affinity for spectrin and actin. Previous studies showed that negative regulation of E16 splicing is mediated by the binding of hnRNP A/B proteins to silencer elements in the exon and that downregulation of hnRNP A/B proteins in erythroblasts leads to activation of E16 inclusion. This paper demonstrates that positive regulation of E16 splicing can be mediated by Fox-2 or Fox-1, two closely related splicing factors that possess identical RNA recognition motifs. SELEX experiments with human Fox-1 revealed highly selective binding to the hexamer UGCAUG. Both Fox-1 and Fox-2 were able to bind the conserved UGCAUG elements in the proximal intron downstream of E16, and both could activate E16 splicing in HeLa cell co-transfection assays in a UGCAUG-dependent manner. Conversely, knockdown of Fox-2 expression, achieved with two different siRNA sequences resulted in decreased E16 splicing. Moreover, immunoblot experiments demonstrate mouse erythroblasts express Fox-2, but not Fox-1. These findings suggest that Fox-2 is a physiological activator of E16 splicing in differentiating erythroid cells in vivo. Recent experiments show that UGCAUG is present in the proximal intron sequence of many tissue-specific alternative exons, and we propose that the Fox family of splicing enhancers plays an important role in alternative splicing switches during differentiation in metazoan organisms.

  2. Updated Radio Sigma-D Relation for Galactic Supernova Remnants

    Science.gov (United States)

    Pavlovic, M. Z.; Dobardzic, A.; Vukotic, B.; Urosevic, D.

    2014-12-01

    We present the updated empirical radio surface-brightness-to-diameter (Sigma - D) relation for supernova remnants (SNRs) in our Galaxy. Our original calibration sample of Galactic SNRs with independently determined distances (Pavlovic et al. 2013, hereafter Paper I) is reconsidered and updated with data which became available in the past two years. The orthogonal fitting procedure and probability-density-function-based (PDF) method are applied to the calibration sample in the log Sigma - log D plane. Non-standard orthogonal regression keeps the Sigma-D and D-Sigma relations invariant within estimated uncertainties. Our previous Monte Carlo simulations verified that the slopes of the empirical Sigma-D relation should be determined by using the orthogonal regression, because of its good performances for data sets with severe scatter. The updated calibration sample contains 65 shell SNRs. 6 new Galactic SNRs are added to the sample from Paper I, one is omitted and distances are changed for 10 SNRs. The slope derived is here slightly steeper (β ≈ 5.2) than the Sigma-D slope in Paper I (β ≈ 4.8). The PDF method relies on data points density maps which can provide more reliable calibrations that preserve more information contained in the calibration sample. We estimate distances to five new faint Galactic SNRs discovered for the first time by Canadian Galactic Plane Survey, and obtained distances of 2.3, 4.0, 1.3, 2.9 and 4.7 kiloparsecs for G108.5+11.0, G128.5+2.6, G149.5+3.2, G150.8+3.8 and G160.1-1.1, respectively. The updated empirical relation is used to estimate distances of 160 shell Galactic SNRs and new results change their distance scales up to 15 per cent, compared to the results from Paper I. The PDF calculation can provide even few times higher or lower values in comparison with the orthogonal fit, as it uses a totally different approach. However, on average, this difference is 32, 24 and 18 per cent for mode, median and mean distances.

  3. Sigma-1 Receptor Imaging in the Brain: Cerebral sigma-1 receptors and cognition: Small-animal PET studies using 11C-SA4503

    OpenAIRE

    Kuzhuppilly Ramakrishnan, Nisha

    2014-01-01

    The sigma-1 receptor is a unique orphan receptor, strongly expressed in neurons and glia. Sigma-1 receptors are involved in several central nervous system (CNS) disorders like depression, anxiety, psychosis, schizophrenia, Parkinson’s disease, Alzheimer’s disease, addiction and neuropathic pain. Several CNS drugs like haloperidol, donepezil, rimcazole, fluvoxamine, sertraline and clorgyline have moderate to high sigma-1 receptor affinity. Pharmaceutical companies currently involved in R&D and...

  4. Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis.

    Directory of Open Access Journals (Sweden)

    Nancy A Turner

    Full Text Available BACKGROUND: Vascular endothelial cells (ECs express and release protein components of the complement pathways, as well as secreting and anchoring ultra-large von Willebrand factor (ULVWF multimers in long string-like structures that initiate platelet adhesion during hemostasis and thrombosis. The alternative complement pathway (AP is an important non-antibody-requiring host defense system. Thrombotic microangiopathies can be associated with defective regulation of the AP (atypical hemolytic-uremic syndrome or with inadequate cleavage by ADAMTS-13 of ULVWF multimeric strings secreted by/anchored to ECs (thrombotic thrombocytopenic purpura. Our goal was to determine if EC-anchored ULVWF strings caused the assembly and activation of AP components, thereby linking two essential defense mechanisms. METHODOLOGY/PRINCIPAL FINDINGS: We quantified gene expression of these complement components in cultured human umbilical vein endothelial cells (HUVECs by real-time PCR: C3 and C5; complement factor (CF B, CFD, CFP, CFH and CFI of the AP; and C4 of the classical and lectin (but not alternative complement pathways. We used fluorescent microscopy, monospecific antibodies against complement components, fluorescent secondary antibodies, and the analysis of >150 images to quantify the attachment of HUVEC-released complement proteins to ULVWF strings secreted by, and anchored to, the HUVECs (under conditions of ADAMTS-13 inhibition. We found that HUVEC-released C4 did not attach to ULVWF strings, ruling out activation of the classical and lectin pathways by the strings. In contrast, C3, FB, FD, FP and C5, FH and FI attached to ULVWF strings in quantitative patterns consistent with assembly of the AP components into active complexes. This was verified when non-functional FB blocked the formation of AP C3 convertase complexes (C3bBb on ULVWF strings. CONCLUSIONS/SIGNIFICANCE: AP components are assembled and activated on EC-secreted/anchored ULVWF multimeric

  5. Sigma-model soliton intersections from exceptional calibrations

    CERN Document Server

    Portugues, R

    2002-01-01

    A first-order `BPS' equation is obtained for 1/8 supersymmetric intersections of soliton-membranes (lumps) of supersymmetric (4+1)-dimensional massless sigma models, and a special non-singular solution is found that preserves 1/4 supersymmetry. For 4-dimensional hyper-K\\"ahler target spaces ($HK_4$) the BPS equation is shown to be the low-energy limit of the equation for a Cayley-calibrated 4-surface in $\\bE^4\\times HK_4$. Similar first-order equations are found for stationary intersections of Q-lump-membranes of the massive sigma model, but now generic solutions preserve either 1/8 supersymmetry or no supersymmetry, depending on the time orientation.

  6. D-brane Solitons in Supersymmetric Sigma-Models

    CERN Document Server

    Gauntlett, J P; Tong, D; Townsend, P K; Gauntlett, Jerome P.; Portugues, Rubén; Tong, David; Townsend, Paul K.

    2001-01-01

    Massive D=4 N=2 supersymmetric sigma models typically admit domain wall (Q-kink) solutions and string (Q-lump) solutions, both preserving 1/2 supersymmetry. We exhibit a new static 1/4 supersymmetric `kink-lump' solution in which a string ends on a wall, and show that it has an effective realization as a BIon of the D=4 super DBI-action. It is also shown to have a time-dependent Q-kink-lump generalization which reduces to the Q-lump in a limit corresponding to infinite BI magnetic field. All these 1/4 supersymmetric sigma-model solitons are shown to be realized in M-theory as calibrated, or `Q-calibrated', M5-branes in an M-monopole background.

  7. IMPROVE MACHINING PROCESS CAPABILITY BY USING SIX-SIGMA

    Directory of Open Access Journals (Sweden)

    Sanjit Ray

    2011-06-01

    Full Text Available Abstract: Six-Sigma is an improvement strategy for achieving customer satisfaction by reducing variation and thus producing products and services better, faster and cheaper. This study presents a Six-Sigma project of an automotive plant illustrating how the DMAIC methodology and statistical techniques were applied to resolve the issue of manufacturing process capability. This project has substantially benefit ted the organization by reducing the variation of bore size of crank case, achieving zero rejection and improving the on time delivery. By using appropriate qualitative and quantitative tools in different phases of the DMAIC methodology, the critical output, key process inputs and root causes were identified, analyzed and validated. This project methodology can be used in general to reduce process variation for any other manufacturing processes as well, which will help in improving customer satisfaction.

  8. LEAN AND SIX SIGMA CONCEPTS APPLICATION IN PHARMACEUTICAL INDUSTRY

    Directory of Open Access Journals (Sweden)

    Katarina Pavlović

    2012-03-01

    Full Text Available LEAN thinking and Six Sigma have been utilized by manufacturing industries to decrease cost and improve quality and productivity by reducing variation and production defects [1]. Because of the dramatic successes in manufacturing, there is rising interest among companies in the pharmaceutical industry, which chooses to implement LEAN in order to accomplish such goals as decreased wait time to release product to the market, reduce production waste, and improve communication with end users and raize quality level both in the production and in testing laboratories. In this article, basics of LEAN and Six Sigma are presented and suggestion was given for application of their concepts in pharmaceutical industry together with harmonization with legal regulation represented by requirements Good Manufacturing Practice (cGMP, in order to work "smarter", more cost-effectively and avoid was ting time and other resources.

  9. LEAN AND SIX SIGMA CONCEPTS - APPLICATION IN PHARMACEUTICAL INDUSTRY

    Directory of Open Access Journals (Sweden)

    Katarina Pavlović

    2011-06-01

    Full Text Available LEAN thinking and Six Sigma have been utilized by manufacturing industries to decrease cost and improve quality and productivity by reducing variation and production defects. Because of the dramatic successes in manufacturing, there is rising interest among companies in the pharmaceutical industry, which choose to implement LEAN in order to accomplish such goals as decreased wait time to release product to the market, reduce production waste, improve communication with end users and raise quality level both in the production and in testing laboratories. In this article, basics of LEAN and Six Sigma are presented and suggestion was given for application of their concepts in pharmaceutical industry together with harmonization with legal regulation represented by requirements Good Manufacturing Practice (cGMP, in order to work "smarter", more cost- effectively and avoid wasting time and other resources.

  10. Exploring pseudoscalar meson scattering in linear sigma models

    Science.gov (United States)

    Black (Speaker), Deirdre; Fariborz, Amir H.; Moussa, Sherif; Nasri, Salah; Schechter, Joseph

    2001-11-01

    The three flavor linear sigma model is studied as a toy model for understanding the role of possible light scalar mesons in the ππ, πK and πɛ elastic scattering channels. We unitarize tree level amplitudes using the K-matrix prescription and, with a sufficiently general model, obtain reasonable fits to the experimental data. The effect of unitarization is very important and leads to the emergence of a nonet of light scalars, with masses below 1 GeV. We compare with a scattering treatment using a more general non-linear sigma model approach and also comment briefly upon how our results fit in with the scalar meson puzzle. .

  11. Look-ahead based sigma-delta modulation

    CERN Document Server

    Janssen, Erwin

    2011-01-01

    The aim of this book is to expand and improve upon the existing knowledge on discrete-time 1-bit look-ahead sigma-delta modulation in general, and to come to a solution for the above mentioned specific issues arising from 1-bit sigma-delta modulation for SA-CD. In order to achieve this objective an analysis is made of the possibilities for improving the performance of digital noise-shaping look-ahead solutions. On the basis of the insights obtained from the analysis, several novel generic 1-bit look-ahead solutions that improve upon the state-of-the-art will be derived and their performance wi

  12. The coupling of Poisson sigma models to topological backgrounds

    CERN Document Server

    Rosa, Dario

    2016-01-01

    We extend the coupling to the topological backgrounds, recently worked out for the 2-dimensional BF-model, to the most general Poisson sigma models. The coupling involves the choice of a Casimir function on the target manifold and modifies the BRST transformations. This in turn induces a change in the BRST cohomology of the resulting theory. The observables of the coupled theory are analyzed and their geometrical intrepretation is given. We finally couple the theory to 2-dimensional topological gravity: this is the first step to study a topological string theory in propagation on a Poisson manifold. As an application, we show that the gauge-fixed vectorial supersymmetry of the Poisson sigma models has a natural explanation in terms of the theory coupled to topological gravity.

  13. A Delta-Sigma beamformer with integrated apodization

    DEFF Research Database (Denmark)

    Tomov, Borislav Gueorguiev; Stuart, Matthias Bo; Hemmsen, Martin Christian;

    2013-01-01

    This paper presents a new design of a discrete time Delta-Sigma (ΔΣ) oversampled ultrasound beamformer which integrates individual channel apodization by means of variable feedback voltage in the Delta-Sigma analog to digital (A/D) converters. The output bit-width of each oversampled A/D converter...... remains the same as in an unmodified one. The outputs of all receiving channels are delayed and summed, and the resulting multi-bit sample stream is filtered and decimated to become an image line. The simplicity of this beamformer allows the production of high-channel-count or very compact beamformers...... suitable for 2-D arrays or compact portable scanners. The new design is evaluated using measured data from the research scanner SARUS and a BK-8811 192 element linear array transducer (BK Medical, Herlev, Denmark), insonifying a water-filled wire phantom containing four wires orthogonal to the image plane...

  14. Nonlinear Sigma Models with Compact Hyperbolic Target Spaces

    CERN Document Server

    Gubser, Steven; Schoenholz, Samuel S; Stoica, Bogdan; Stokes, James

    2015-01-01

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the $O(2)$ model. Unlike in the $O(2)$ case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. The diversity of compact hyperbolic manifolds suggest...

  15. Six sigma for organizational excellence a statistical approach

    CERN Document Server

    Muralidharan, K

    2015-01-01

    This book discusses the integrated concepts of statistical quality engineering and management tools. It will help readers to understand and apply the concepts of quality through project management and technical analysis, using statistical methods. Prepared in a ready-to-use form, the text will equip practitioners to implement the Six Sigma principles in projects. The concepts discussed are all critically assessed and explained, allowing them to be practically applied in managerial decision-making, and in each chapter, the objectives and connections to the rest of the work are clearly illustrated. To aid in understanding, the book includes a wealth of tables, graphs, descriptions and checklists, as well as charts and plots, worked-out examples and exercises. Perhaps the most unique feature of the book is its approach, using statistical tools, to explain the science behind Six Sigma project management and integrated in engineering concepts. The material on quality engineering and statistical management tools of...

  16. Off-shell BCJ Relation in Nonlinear Sigma Model

    CERN Document Server

    Chen, Gang; Liu, Hanqing

    2016-01-01

    We investigate relations among tree-level off-shell currents in nonlinear sigma model. Under Cayley parametrization, we propose and prove a general revised BCJ relation for even-point currents. Unlike the on-shell BCJ relation, the off-shell one behaves quite differently from Yang-Mills theory although the algebraic structure is the same. After performing the permutation summation in the revised BCJ relation, the sum is non-vanishing, instead, it equals to the sum of sub-current products with the BCJ coefficients under a specific ordering, which is presented by an explicit formula. Taking on-shell limit, this identity is reduced to the on-shell BCJ relation, and thus provides the full off-shell correspondence of tree-level BCJ relation in nonlinear sigma model.

  17. Rethinking behavioral health processes by using design for six sigma.

    Science.gov (United States)

    Lucas, Anthony G; Primus, Kelly; Kovach, Jamison V; Fredendall, Lawrence D

    2015-02-01

    Clinical evidence-based practices are strongly encouraged and commonly utilized in the behavioral health community. However, evidence-based practices that are related to quality improvement processes, such as Design for Six Sigma, are often not used in behavioral health care. This column describes the unique partnership formed between a behavioral health care provider in the greater Pittsburgh area, a nonprofit oversight and monitoring agency for behavioral health services, and academic researchers. The authors detail how the partnership used the multistep process outlined in Design for Six Sigma to completely redesign the provider's intake process. Implementation of the redesigned process increased access to care, decreased bad debt and uncollected funds, and improved cash flow--while consumer satisfaction remained high. PMID:25642607

  18. Is health care ready for Six Sigma quality?

    Science.gov (United States)

    Chassin, M R

    1998-01-01

    Serious, widespread problems exist in the quality of U.S. health care: too many patients are exposed to the risks of unnecessary services; opportunities to use effective care are missed; and preventable errors lead to injuries. Advanced practitioners of industrial quality management, like Motorola and General Electric, have committed themselves to reducing the frequency of defects in their business processes to fewer than 3.4 per million, a strategy known as Six Sigma Quality. In health care, quality problems frequently occur at rates of 20 to 50 percent, or 200,000 to 500,000 per million. In order to approach Six Sigma levels of quality, the health care sector must address the underlying causes of error and make important changes: adopting new educational models; devising strategies to increase consumer awareness; and encouraging public and private investment in quality improvement. PMID:9879303

  19. Hadron Properties in a Chiral Quark-Sigma Model

    CERN Document Server

    Rashdan, M; El-Kholy, S; Abu-Shady, M

    2011-01-01

    Within a chiral quark sigma model in which quarks interact via the exchange of sigma and pi-mesons, hadron properties are investigated. This model of the nucleon and delta is based on the idea that strong QCD forces on very short distances (a small length scales 0.2- 1 fm) result in hidden chiral SU(2)xSU(2) symmetry and that there is a separation of roles between these forces which are responsible for binding quarks in hadrons and the forces which produce absolute confinement. We have solved the field equations in the mean field approximation for the hedgehog baryon state with different sets of model parameters. A new parametrization which well describe the nucleon properties has been introduced and compared with experimental data.

  20. Digital Pixel Sensor Array with Logarithmic Delta-Sigma Architecture

    Directory of Open Access Journals (Sweden)

    Jing Li

    2013-08-01

    Full Text Available Like the human eye, logarithmic image sensors achieve wide dynamic range easily at video rates, but, unlike the human eye, they suffer from low peak signal-to-noise-and-distortion ratios (PSNDRs. To improve the PSNDR, we propose integrating a delta-sigma analog-to-digital converter (ADC in each pixel. An image sensor employing this architecture is designed, built and tested in 0.18 micron complementary metal-oxide-semiconductor (CMOS technology. It achieves a PSNDR better than state-of-the-art logarithmic sensors and comparable to the human eye. As the approach concerns an array of many ADCs, we use a small-area low-power delta-sigma design. For scalability, each pixel has its own decimator. The prototype is compared to a variety of other image sensors, linear and nonlinear, from industry and academia.

  1. Digital pixel sensor array with logarithmic delta-sigma architecture.

    Science.gov (United States)

    Mahmoodi, Alireza; Li, Jing; Joseph, Dileepan

    2013-01-01

    Like the human eye, logarithmic image sensors achieve wide dynamic range easily at video rates, but, unlike the human eye, they suffer from low peak signal-to-noise-and-distortion ratios (PSNDRs). To improve the PSNDR, we propose integrating a delta-sigma analog-to-digital converter (ADC) in each pixel. An image sensor employing this architecture is designed, built and tested in 0.18 micron complementary metal-oxide-semiconductor (CMOS) technology. It achieves a PSNDR better than state-of-the-art logarithmic sensors and comparable to the human eye. As the approach concerns an array of many ADCs, we use a small-area low-power delta-sigma design. For scalability, each pixel has its own decimator. The prototype is compared to a variety of other image sensors, linear and nonlinear, from industry and academia. PMID:23959239

  2. Lepton Private Higgs and the discrete group \\Sigma(81)

    CERN Document Server

    BenTov, Yoni

    2012-01-01

    We use the discrete group \\Sigma(81) = (Z_3 x Z_3 x Z_3)\\rx Z_3 to suggest a relation among the off-diagonal entries of the neutrino mass matrix, as well as to explain the muon magnetic moment anomaly, a_\\mu^exp-a_\\mu^SM ~ 10^{-9}. We predict three new nearly degenerate Higgs doublets with masses of order ~500 GeV to ~ 1 TeV, and three nearly degenerate SM-singlet TeV-scale neutrinos. The largest scale in the model is ~10 TeV, so there is no severe hierarchy problem. The appendix is devoted to the group theory of \\Sigma(81).

  3. Aplikace lean six sigma v racionalizaci technologické linky

    OpenAIRE

    Petráš, Jaroslav

    2008-01-01

    Předkládaná práce se zabývá metodami konceptu lean six sigma, které se vztahují k problematice zefektivňování průmyslových procesů. Část práce je věnována postupu řešení optimalizace pomocí modelu DMAIC a propojení se six sigma a TOC. Hlavní pozornost je zaměřena na použití modelu DMAIC při vyhodnocování na data z technologické linky Cobalt firmy Motorola.

  4. Applying a Hybrid MCDM Model for Six Sigma Project Selection

    Directory of Open Access Journals (Sweden)

    Fu-Kwun Wang

    2014-01-01

    Full Text Available Six Sigma is a project-driven methodology; the projects that provide the maximum financial benefits and other impacts to the organization must be prioritized. Project selection (PS is a type of multiple criteria decision making (MCDM problem. In this study, we present a hybrid MCDM model combining the decision-making trial and evaluation laboratory (DEMATEL technique, analytic network process (ANP, and the VIKOR method to evaluate and improve Six Sigma projects for reducing performance gaps in each criterion and dimension. We consider the film printing industry of Taiwan as an empirical case. The results show that our study not only can use the best project selection, but can also be used to analyze the gaps between existing performance values and aspiration levels for improving the gaps in each dimension and criterion based on the influential network relation map.

  5. Effects of the Tsallis distribution in the linear sigma model

    CERN Document Server

    Ishihara, Masamichi

    2014-01-01

    The effects of the Tsallis distribution which has a parameter $q$ on physical quantities are studied using the linear sigma model in chiral phase transitions. The temperature dependences of the condensate and mass for various $q$ are shown, where the Tsallis distribution approaches the Boltzmann-Gibbs distribution as $q$ approaches $1$. The critical temperature and energy density are described with digamma function, and the $q$ dependences of these quantities and the extension of Stefan-Boltzmann limit of the energy density are shown. The following facts are clarified. The chiral symmetry restoration for $q>1$ occurs at low temperature, compared with the restoration for $q=1$. The sigma mass and pion mass reflect the restoration. The critical temperature decreases monotonically as $q$ increases. The small deviation from the Boltzmann-Gibbs distribution results in the large deviations of physical quantities, especially the energy density. It is displayed from the energetic point of view that the small deviatio...

  6. Sigma, Kappa, fo(980) and a0(980)

    CERN Document Server

    Bugg, D V

    2005-01-01

    Both sigma and kappa are well established from E791 data on D->3pi and Ds->Kpipi and BES II data on J/Psi -> omega pi pi and KKpipi. These fits are accurately consistent with pipi and Kpi elastic scattering when one allows for the Adler zero which arises from Chiral Symmetry Breaking. The phase variation with mass is consistent between elastic scattering and production data. Possible interpretations of sigma, kappa, fo(980) and ao(980) are explored. The experimental ratio g^2(fo(980)->KK)/g^2(ao(980)->KK) = 2.7+-0.5 suggests strongly that fo(980) has a large KK component in its wave function. This is a natural consequence of its pole lying very close to the KK threshold.

  7. Making Supersymmetric Quivers from N =(0,2) Sigma Models

    CERN Document Server

    Shifman, Mikhail; Yung, Alexei

    2014-01-01

    We show how to construct quiver-like (0,2) sigma models starting from n copies of (2,2) CP(N-1) models (or similar more generic models). These "quivers" present a natural generalization of the non-minimally deformed (2,2) model with an extra (0,2) fermion superfield on tangle bundle T[CP(N-1)xC^1] considered previously. A remarkable feature observed is elimination of the spontaneous supersymmetry breaking. We study supersymmetric vacua and determine the particle spectrum in the large-N limit. We then examine the \\beta -functions of our quiver-like (0,2) sigma models and show that under certain conditions they develop an infrared fixed point in the perturbative domain.

  8. Is health care ready for Six Sigma quality?

    Science.gov (United States)

    Chassin, M R

    1998-01-01

    Serious, widespread problems exist in the quality of U.S. health care: too many patients are exposed to the risks of unnecessary services; opportunities to use effective care are missed; and preventable errors lead to injuries. Advanced practitioners of industrial quality management, like Motorola and General Electric, have committed themselves to reducing the frequency of defects in their business processes to fewer than 3.4 per million, a strategy known as Six Sigma Quality. In health care, quality problems frequently occur at rates of 20 to 50 percent, or 200,000 to 500,000 per million. In order to approach Six Sigma levels of quality, the health care sector must address the underlying causes of error and make important changes: adopting new educational models; devising strategies to increase consumer awareness; and encouraging public and private investment in quality improvement.

  9. 中国企业六西格玛管理实施模型研究%Research on the Implementation Model of Six Sigma for Chinese Companies

    Institute of Scientific and Technical Information of China (English)

    崔宝

    2012-01-01

    随着六西格玛管理的迅速推广,不少中国企业通过实施六西格玛取得了显著的效益,当在实施六西格玛管理过程中也存在很多问题.因此,了解六西格玛在中国的实施现状,总结适合中国企业实施六西格玛管理的模式至关重要.文章基于对六西格玛管理关键成功因素的分析,构建了适合中国企业的六西格玛管理实施模型.为中国企业通过实施六西格玛管理建立一套持续改进的管理模式奠定了基础.%With the rapid promotion of Six Sigma, Many Chinese companies benefit a lot. However, there also exist lots of problems during the implementation process of Six Sigma. As a result, it is crucial to know the status of Six Sigma in China and find an implementation model of Six Sigma for Chinese companies. The author develops an implementation model of Six Sigma for Chinese companies based on literature research of Six Sigma CSFs (Critical to success factors). This article constructs a foundation for the formation of a continuous improvement management by implementation of Six Sigma in Chinese companies.

  10. Contribuições do Seis Sigma: estudos de caso em multinacionais Contributions from Six Sigma: case studies in multinationals

    Directory of Open Access Journals (Sweden)

    Adriana Barbosa Santos

    2010-03-01

    Full Text Available A literatura sugere que o Seis Sigma trouxe contribuições sob vários aspectos, tanto no âmbito da gestão da qualidade como também da gestão estratégica. No entanto, ainda há certa escassez de informações sobre esse assunto no cenário organizacional brasileiro. Este artigo visa reduzir essa carência da literatura, mostrando uma visão prática sobre as contribuições decorrentes dos investimentos no Seis Sigma para empresas do Brasil. A relevância de requisitos essenciais - como conceito de qualidade; combinação das abordagens estatística e estratégica; sistematização metodológica; formação de especialistas; e gestão de projetos - é discutida tanto em âmbito teórico-conceitual como prático. O método do estudo de caso foi aplicado para obter o embasamento empírico da pesquisa. Os investimentos no Seis Sigma feitos por duas subsidiárias brasileiras de empresas multinacionais norte-americanas (uma de manufatura e uma de serviços são apresentados e reforçam a relevância dos requisitos supracitados.The literature suggests that Six Sigma has made many contributions to quality and strategic management. However, there is a certain lack of information about this subject in the Brazilian organizational scene. This paper aims to reduce this lack by means of a practical vision of the contributions that came from the investment of Brazilian companies in Six Sigma implementation. The relevance of essentials requirements, such as: quality concept; combination of statistical and strategic approaches; methodological systemizing; belt training; and project management is discussed from both the theoretical and practical aspects. Case study method was applied to obtain an empirical basis for the research. The investment in Six Sigma undertaken by two Brazilian branches of large multinationals (one a Manufacturing Company and the other a Service Company are described and analyzed, underlining the relevance of these requirements.

  11. On the large $N$ expansion in hyperbolic sigma-models

    CERN Document Server

    Niedermaier, Max

    2007-01-01

    Invariant correlation functions for ${\\rm SO}(1,N)$ hyperbolic sigma-models are investigated. The existence of a large $N$ asymptotic expansion is proven on finite lattices of dimension $d \\geq 2$. The unique saddle point configuration is characterized by a negative gap vanishing at least like 1/V with the volume. Technical difficulties compared to the compact case are bypassed using horospherical coordinates and the matrix-tree theorem.

  12. Stability of sinusoidal responses of interpolative sigma delta modulators

    OpenAIRE

    Ho, Charlotte Yuk-Fan; Ling, Bingo Wing-Kuen

    2007-01-01

    In this paper, stability of sinusoidal responses of interpolative sigma delta modulators (SDMs) is investigated. It is found that interpolative SDMs may switch from unstable to stable behaviors even though the magnitude or the frequency of the input sinusoidal signals increase. Hence, the input magnitude stability margin and the input frequency stability margin are redefined as the minimum input magnitude and the minimum input frequency of the input sinusoidal signals such that the output of ...

  13. Existence of $\\sigma$ meson in $\\pi-\\pi$ scattering

    CERN Document Server

    Harada, M

    1997-01-01

    In this talk I summarize a recently proposed mechanism to understand pi pi scattering to 1 GeV. The model is motivated by the 1/Nc expansion to QCD, and includes a current algebra contact term and resonant pole exchanges. Chiral symmetry plays an important role in restricting the form of the interactions. The existence of a broad low energy scalar (sigma) is indicated.

  14. A community hospital's journey into Lean Six Sigma.

    Science.gov (United States)

    Stuenkel, Kurt; Faulkner, Taunya

    2009-01-01

    The implementation of Lean Six Sigma and 100-day workouts throughout the 304-bed Floyd Medical Center community hospital organization has led to sustainable results and a marked change in culture. The organization-wide learning of such an effort is deep and intehse, and to remain focused and successful it must be a priority of top management. The workout methodology can assist the organization to carry projects to completion and to achieve rapid implementation of desired improvements.

  15. Linear $\\sigma$ model for the Goldstone Higgs - Experimental tests

    CERN Document Server

    Saa, Sara

    2016-01-01

    In order to explore a possible dynamical nature for the Higgs field (such as its being a pseudo-Goldstone boson) we develop a renormalizable Lagrangian based on the minimal $SO(5)$ linear $\\sigma$-model with the symmetry softly broken to $SO(4)$, including gauge bosons and fermions. We then present the phenomenological implications and constraints from precision observables and the impact on present and future LHC data.

  16. Is Health Care Ready for Six Sigma Quality?

    OpenAIRE

    Chassin, Mark R.

    1998-01-01

    Serious, widespread problems exist in the quality of U.S. health care: too many patients are exposed to the risks of unnecessary services; opportunities to use effective care are missed; and preventable errors lead to injuries. Advanced practitioners of industrial quality management, like Motorola and General Electric, have committed themselves to reducing the frequency of defects in their business processes to fewer than 3.4 per million, a strategy known as Six Sigma Quality. In health care,...

  17. Implementation of Design for Six Sigma on Mass Customization Companies

    OpenAIRE

    Jurado Lara, Laura

    2012-01-01

    The role of quality control is to correctly translate customers´ requirements into materialized products to achieve customers’ satisfaction. Today Product Development Process (PDP) becomes the stage to improve and to obtain successful products. In the 1980s, Six Sigma appeared as an attempt to improve some aspects of products and services in order to reduce failures in production as much as possible. But there still was a lack of customer perspective over product development project. This the...

  18. Evidence for the rare decay $\\Sigma^+ \\to p \\mu^+ \\mu^-$

    CERN Document Server

    The LHCb Collaboration

    2016-01-01

    A search for the rare decay $\\Sigma^+ \\to p \\mu^+ \\mu^-$ is performed using $pp$ collision data recorded by the LHCb experiment at centre-of-mass energies $\\sqrt{s} = 7$ and $8 TeV$, corresponding to an integrated luminosity of $3 ~ \\text {fb}^{-1}$. An excess of events is observed with respect to the background expectations with a signal significance of 4.0 standard deviations. No significant structure is observed in the dimuon invariant mass distribution.

  19. Roles of sigma-1 receptors in Alzheimer’s disease

    OpenAIRE

    Jin, Jia-li; Fang, Min; Zhao, Yan-Xin; Liu, Xue-Yuan

    2015-01-01

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of senile dementia all over the world. Still no existing drugs can effectively reverse the cognitive impairment. However, Sigma-1 (σ-1) receptors have been long implicated in multiple neurological and psychiatric conditions over these years. In this review, we discuss the current understanding of σ-1 receptor functions. Through regulation of lipid rafts, secretases, kinases, neuroceptors and ion channel...

  20. The innovative use of Six Sigma in home care.

    Science.gov (United States)

    Elberfeld, Adrienne; Bennis, Sandra; Ritzius, Jeannie; Yhlen, David

    2007-01-01

    The Prospective Payment System had significant impact on home healthcare agencies throughout the nation. Virtua Home Care, located in Southern New Jersey, realized the need for process improvement in order to remain viable. Six Sigma was introduced to the agency and the Define, Measure, Analyze, Improve, and Control processes were initiated to achieve sustainable results, and within 9 months, Virtua Home Care improved regulatory compliance, experienced a deficiency-free survey, and recognized a 1.2 million dollars financial gain.