Sample records for alternative procedures approved

  1. 40 CFR 1065.12 - Approval of alternate procedures. (United States)


    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Approval of alternate procedures. 1065.12 Section 1065.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Applicability and General Provisions § 1065.12 Approval...

  2. 40 CFR 136.5 - Approval of alternate test procedures. (United States)


    ... data submitted by the applicant and any available EPA analysis of those data. (4) Following a period of... PROGRAMS (CONTINUED) GUIDELINES ESTABLISHING TEST PROCEDURES FOR THE ANALYSIS OF POLLUTANTS § 136.5... is complete. If the application is incomplete, the applicant shall be informed of the...

  3. 77 FR 38523 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe... (United States)


    ... Protection Agency, 26 West Martin Luther King Drive, Cincinnati, OH 45268; telephone number: (513) 569-7652...) method for the determination of atrazine and simazine, which are regulated in drinking water as specified... chromatography, which is used in the approved methods for the determination of atrazine and simazine....

  4. 12 CFR 611.510 - Approval procedures. (United States)


    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Approval procedures. 611.510 Section 611.510 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Transfer of Authorities § 611.510 Approval procedures. (a) Upon receipt of approval of a resolution by the Farm...

  5. 7 CFR 3015.112 - Approval procedures. (United States)


    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Approval procedures. 3015.112 Section 3015.112 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Programmatic Changes and Budget...

  6. 28 CFR 549.51 - Approval procedures. (United States)


    ... SERVICES Plastic Surgery § 549.51 Approval procedures. The Clinical Director shall consider individually any request from an inmate or a BOP medical consultant. (a) In circumstances where plastic surgery is... the Clinical Director recommends plastic surgery for the good order and security of the...

  7. 29 CFR 4221.14 - PBGC-approved arbitration procedures. (United States)


    ... 29 Labor 9 2010-07-01 2010-07-01 false PBGC-approved arbitration procedures. 4221.14 Section 4221... LIABILITY FOR MULTIEMPLOYER PLANS ARBITRATION OF DISPUTES IN MULTIEMPLOYER PLANS § 4221.14 PBGC-approved arbitration procedures. (a) Use of PBGC-approved arbitration procedures. In lieu of the procedures...

  8. 48 CFR 1845.607-170 - Contractor's approved scrap procedure. (United States)


    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor's approved scrap... Contractor Inventory 1845.607-170 Contractor's approved scrap procedure. (a) When a contractor has an approved scrap procedure, certain property may be routinely disposed of in accordance with that...

  9. 27 CFR 22.22 - Alternate methods or procedures; and emergency variations from requirements. (United States)


    ... OF TAX-FREE ALCOHOL Administrative Provisions Authorities § 22.22 Alternate methods or procedures..., conditions or limitations set forth in the approval, authority for the variation from requirements...

  10. Motor Development: Manual of Alternative Procedures. (United States)

    McCormack, James E.

    The manual of alternative procedures for teaching handicapped children focuses on programming, planning, and implementing training in the gross motor (posture, limb control, locomotion) and fine motor (facial, digital) skills. The manual consists of the following sections: specific teaching tactics commonly used in motor training stiuations…

  11. 46 CFR 160.077-6 - Approval procedures. (United States)


    ... PFD of sufficiently similar design. (2) Engineering analysis showing that the test is not applicable...) Alternative Requirements. A PFD that does not meet requirements in this subpart may still be approved if the device— (1) Meets other requirements prescribed by the Commandant in place of or in addition...

  12. French approval procedures for pyrotechnical automotive safety equipments


    Aufauvre, Lionel; Branka, Ruddy


    International audience; Pyrotechnical articles for civil uses may be subject to national procedures before placing on the market According to the French decree n°90-153, 16 February 1990 as modified; explosives that are dispensed with EC marking and that are not excluded of the decree application have to conform to approved types. Pyrotechnical automotive safety equipments such gas generators for airbag modules or seat-belt pretensioners, pyrotechnie relay compositions and/or igniters inside ...

  13. 48 CFR 45.606-2 - Contractor without an approved scrap procedure. (United States)


    ... approved scrap procedure. 45.606-2 Section 45.606-2 Federal Acquisition Regulations System FEDERAL... Contractor without an approved scrap procedure. The contractor shall submit an inventory disposal schedule for all scrap....

  14. BWR Steam Dryer Alternating Stress Assessment Procedures

    Energy Technology Data Exchange (ETDEWEB)

    Morante, R. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hambric, S. A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ziada, S. [Brookhaven National Lab. (BNL), Upton, NY (United States)


    This report presents an overview of Boiling Water Reactor (BWR) steam dryer design; the fatigue cracking failures that occurred at the Quad Cities (QC) plants and their root causes; a history of BWR Extended Power Uprates (EPUs) in the USA; and a discussion of steam dryer modifications/replacements, alternating stress mechanisms on steam dryers, and structural integrity evaluations (static and alternating stress).

  15. 48 CFR 45.606-1 - Contractor with an approved scrap procedure. (United States)


    ... approved scrap procedure. 45.606-1 Section 45.606-1 Federal Acquisition Regulations System FEDERAL... Contractor with an approved scrap procedure. (a) The contractor may dispose of scrap resulting from production or testing under this contract without Government approval. However, if the scrap...

  16. Alternative antimicrobial commercial egg washing procedures (United States)

    Commercial table eggs are washed prior to packaging. Standard wash procedures use an alkaline pH and warm water. If a cool water method could be developed that would still provide a microbiologically safe egg, the industry may save energy costs associated with water heating. Four wash procedures ...

  17. 5 CFR 2471.6 - Investigation of request; Panel procedures; approval of binding arbitration. (United States)


    ... procedures; approval of binding arbitration. 2471.6 Section 2471.6 Administrative Personnel FEDERAL LABOR... procedures; approval of binding arbitration. (a) Upon receipt of a request for consideration of an impasse... arbitration or mediation-arbitration (by a Panel designee or a private arbitrator). Following procedures...

  18. 42 CFR 488.60 - Special procedures for approving end stage renal disease facilities. (United States)


    ... ENFORCEMENT PROCEDURES Special Requirements § 488.60 Special procedures for approving end stage renal disease... 42 Public Health 5 2010-10-01 2010-10-01 false Special procedures for approving end stage renal disease facilities. 488.60 Section 488.60 Public Health CENTERS FOR MEDICARE & MEDICAID...

  19. 75 FR 18782 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Alternate Monitoring... (United States)


    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Indiana; Alternate Monitoring Requirements for Indianapolis Power and Light--Harding Street Station AGENCY: Environmental... State Implementation Plan alternative monitoring requirements for Indianapolis Power and Light...

  20. An Evaluation of Alternative Screening Procedures. (United States)

    Reid, Carol; Romanoff, Brenda; Algozzine, Bob; Udall, Ann


    This study compared the Problem Solving Assessment (PSA) procedure, an application based on Gardner's theory of multiple intelligences, with more traditional criteria for the identification of minority students for gifted education programs. Although positive correlations among approaches and intelligences were observed, different groups of…

  1. 75 FR 18757 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Alternate Monitoring... (United States)


    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Indiana; Alternate Monitoring Requirements for Indianapolis Power and Light--Harding Street Station AGENCY: Environmental... approve as ] a revision to its State Implementation Plan (SIP) alternative monitoring requirements for...

  2. Alternative Antimicrobial Commercial Egg Washing Procedures. (United States)

    Hudson, Lauren K; Harrison, Mark A; Berrang, Mark E; Jones, Deana R


    Commercial table eggs are washed prior to packaging. Standard wash procedures use an alkaline pH and warm water. If a cool water method could be developed that would still provide a microbiologically safe egg, the industry may save energy costs associated with water heating. Four wash procedures were evaluated for Salmonella reduction: pH 11 at 48.9°C (industry standard), pH 11 at ambient temperature (∼20°C), pH 6 at 48.9°C, and pH 6 at ambient temperature. Alkaline washes contained potassium hydroxide-based detergent, while pH 6 washes contained approximately 200 ppm of chlorine and a proprietary chlorine stabilizer (T-128). When eggs were inoculated by immersion in a cell suspension of Salmonella Enteritidis and Salmonella Typhimurium, all treatments resulted in a slight and similar reduction of Salmonella numbers (approximately 0.77 log CFU/ml of shell emulsion reduction). When eggs were inoculated by droplet on the shell surface, Salmonella counts were reduced by approximately 5 log CFU when washed with chlorine plus the chlorine stabilizer at both temperatures and with the alkaline wash at the high temperature. The reductions in Salmonella by these treatments were not significantly (P > 0.05) different from each other but were significantly (P < 0.05) more than the reduction observed for the 20°C alkaline treatment and 20°C control water treatments. Ambient temperature acidic washes reduced Salmonella contamination to the same degree as the standard pH 11 warm water wash and may be a viable option to reduce cost, increase shelf life, and slow pathogen growth in and on shell eggs.

  3. 46 CFR 160.054-7 - Procedure for approval. (United States)


    ... fully the construction, material specification, arrangement, and list of contents to the Commander of... the first-aid kit. At the time of selection of the pre-approval sample, the manufacturer shall...

  4. 25 CFR 291.14 - How can Class III gaming procedures approved by the Secretary be amended? (United States)


    ... 25 Indians 1 2010-04-01 2010-04-01 false How can Class III gaming procedures approved by the... ECONOMIC ENTERPRISES CLASS III GAMING PROCEDURES § 291.14 How can Class III gaming procedures approved by the Secretary be amended? An Indian tribe may ask the Secretary to amend approved Class III...

  5. 27 CFR 24.22 - Alternate method or procedure. (United States)


    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Alternate method or procedure. 24.22 Section 24.22 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Administrative and Miscellaneous Provisions...

  6. 46 CFR 153.1101 - Procedures for getting a Surveyor: Approval of Surveyors. (United States)


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Procedures for getting a Surveyor: Approval of Surveyors. 153.1101 Section 153.1101 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Operations Approval of Surveyors...

  7. 25 CFR 30.113 - How does the Secretary review and approve an alternative definition of AYP? (United States)


    ... EDUCATION ADEQUATE YEARLY PROGRESS Defining Adequate Yearly Progress Approval of Alternative Definition § 30.113 How does the Secretary review and approve an alternative definition of AYP? (a) The tribal... 25 Indians 1 2010-04-01 2010-04-01 false How does the Secretary review and approve an...

  8. A procedure for identifying homologous alternative splicing events

    Directory of Open Access Journals (Sweden)

    Orozco Modesto


    Full Text Available Abstract Background The study of the functional role of alternative splice isoforms of a gene is a very active area of research in biology. The difficulty of the experimental approach (in particular, in its high-throughput version leaves ample room for the development of bioinformatics tools that can provide a useful first picture of the problem. Among the possible approaches, one of the simplest is to follow classical protein function annotation protocols and annotate target alternative splice events with the information available from conserved events in other species. However, the application of this protocol requires a procedure capable of recognising such events. Here we present a simple but accurate method developed for this purpose. Results We have developed a method for identifying homologous, or equivalent, alternative splicing events, based on the combined use of neural networks and sequence searches. The procedure comprises four steps: (i BLAST search for homologues of the two isoforms defining the target alternative splicing event; (ii construction of all possible candidate events; (iii scoring of the latter with a series of neural networks; and (iv filtering of the results. When tested in a set of 473 manually annotated pairs of homologous events, our method showed a good performance, with an accuracy of 0.99, a precision of 0.98 and a sensitivity of 0.93. When no candidates were available, the specificity of our method varied between 0.81 and 0.91. Conclusion The method described in this article allows the identification of homologous alternative splicing events, with a good success rate, indicating that such method could be used for the development of functional annotation of alternative splice isoforms.

  9. 27 CFR 479.64 - Procedure for approval of application. (United States)



  10. 40 CFR 86.162-03 - Approval of alternative air conditioning test simulations. (United States)


    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Approval of alternative air conditioning test simulations. 86.162-03 Section 86.162-03 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1977...

  11. 7 CFR 322.12 - Risk assessment procedures for approving countries. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Risk assessment procedures for approving countries. 322.12 Section 322.12 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND...

  12. Revised guideline for the approval procedure of package designs in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Nitsche, F. [Federal Office for Radiation Protection, Salzgitter (Germany); Roedel, R. [Federal Inst. for Materials Research and Testing, Berlin (Germany)


    The IAEA Regulations for the Safe Transport of Radioactive Material, TS-R-1 are applied in Germany through the implementation of the Dangerous Goods Transport Regulations for class 7 of the International Modal Organisations (ADR, RID, IMDG-Code, ICAO-TI). Based on this the approval procedures for packages designs applied in Germany are in compliance with the provisions of TS-R-1. The Guideline R 003 issued by the Ministry of Transport, Building and Housing (BMVBW) in 1991 is the basis for the package design approval procedures in Germany. This Guideline has been reviewed and revised to reflect latest developments in the regulations as well as in the regulatory practice. In particular it has been extended to the approval procedures of Type C packages, packages subject to transitional arrangements, special form and low dispersible radioactive material and provides more detailed information to the applicant about the requested documentation. Publication of this revised guideline has been delayed but it is expected to take place in October 2004. The paper gives an overview about the main parts and provisions of this revised Guideline R 003 with the focus on package design approval procedures.

  13. 10 CFR 20.2002 - Method for obtaining approval of proposed disposal procedures. (United States)


    ... RADIATION Waste Disposal § 20.2002 Method for obtaining approval of proposed disposal procedures. A licensee... licensee's activities. Each application shall include: (a) A description of the waste containing licensed..., and the proposed manner and conditions of waste disposal; and (b) An analysis and evaluation...

  14. A Schwarz alternating procedure for singular perturbation problems

    Energy Technology Data Exchange (ETDEWEB)

    Garbey, M. [Universit Claude Bernard Lyon, Villeurbanne (France); Kaper, H.G. [Argonne National Lab., IL (United States)


    The authors show that the Schwarz alternating procedure offers a good algorithm for the numerical solution of singular perturbation problems, provided the domain decomposition is properly designed to resolve the boundary and transition layers. They give sharp estimates for the optimal position of the domain boundaries and present convergence rates of the algorithm for various second-order singular perturbation problems. The splitting of the operator is domain-dependent, and the iterative solution of each subproblem is based on a modified asymptotic expansion of the operator. They show that this asymptotic-induced method leads to a family of efficient massively parallel algorithms and report on implementation results for a turning-point problem and a combustion problem.

  15. 34 CFR 668.149 - Special provisions for the approval of assessment procedures for special populations for whom no... (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false Special provisions for the approval of assessment procedures for special populations for whom no tests are reasonably available. 668.149 Section 668.149... the approval of assessment procedures for special populations for whom no tests are...

  16. 27 CFR 20.22 - Alternate methods or procedures; and emergency variations from requirements. (United States)


    ... OF DENATURED ALCOHOL AND RUM Administrative Provisions Authorities § 20.22 Alternate methods or... forth in the approval, authority for the variation from requirements is automatically terminated and...

  17. Analysis of generalized Schwarz alternating procedure for domain decomposition

    Energy Technology Data Exchange (ETDEWEB)

    Engquist, B.; Zhao, Hongkai [Univ. of California, Los Angeles, CA (United States)


    The Schwartz alternating method(SAM) is the theoretical basis for domain decomposition which itself is a powerful tool both for parallel computation and for computing in complicated domains. The convergence rate of the classical SAM is very sensitive to the overlapping size between each subdomain, which is not desirable for most applications. We propose a generalized SAM procedure which is an extension of the modified SAM proposed by P.-L. Lions. Instead of using only Dirichlet data at the artificial boundary between subdomains, we take a convex combination of u and {partial_derivative}u/{partial_derivative}n, i.e. {partial_derivative}u/{partial_derivative}n + {Lambda}u, where {Lambda} is some {open_quotes}positive{close_quotes} operator. Convergence of the modified SAM without overlapping in a quite general setting has been proven by P.-L.Lions using delicate energy estimates. The important questions remain for the generalized SAM. (1) What is the most essential mechanism for convergence without overlapping? (2) Given the partial differential equation, what is the best choice for the positive operator {Lambda}? (3) In the overlapping case, is the generalized SAM superior to the classical SAM? (4) What is the convergence rate and what does it depend on? (5) Numerically can we obtain an easy to implement operator {Lambda} such that the convergence is independent of the mesh size. To analyze the convergence of the generalized SAM we focus, for simplicity, on the Poisson equation for two typical geometry in two subdomain case.

  18. Is suvorexant a better choice than alternative hypnotics? [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Daniel F. Kripke


    Full Text Available Suvorexant is a novel dual orexin receptor antagonist (DORA newly introduced in the U.S. as a hypnotic, but no claim of superiority over other hypnotics has been offered.  The manufacturer argued that the 5 and 10 mg starting doses recommended by the FDA might be ineffective.  The manufacturer's main Phase III trials had not even included the 10 mg dosage, and the 5 mg dosage had not been tested at all in registered clinical trials at the time of approval.  Popular alternative hypnotics may be similarly ineffective, since the FDA has also reduced the recommended doses for zolpidem and eszopiclone.  The "not to exceed" suvorexant dosage of 20 mg does slightly increase sleep.  Because of slow absorption, suvorexant has little effect on latency to sleep onset but some small effect in suppressing wakening after sleep onset and in improving sleep efficiency. The FDA would not approve the manufacturer's preferred 40 mg suvorexant dosage, because of concern with daytime somnolence, driving impairment, and possible narcolepsy-like symptoms.  In its immediate benefits-to-risks ratio, suvorexant is unlikely to prove superior to currently available hypnotics—possibly worse—so there is little reason to prefer over the alternatives this likely more expensive hypnotic less-tested in practice.  Associations are being increasingly documented relating hypnotic usage with incident cancer, with dementia risks, and with premature death.  There is some basis to speculate that suvorexant might be safer than alternative hypnotics in terms of cancer, dementia, infections, and mortality.  These safety considerations will remain unproven speculations unless adequate long-term trials can be done that demonstrate suvorexant advantages.

  19. 42 CFR 488.61 - Special procedures for approval and re-approval of organ transplant centers. (United States)


    ... described at 42 CFR part 488, subpart A apply to transplant centers, including the periodic review of... are not Medicare-approved as of June 28, 2007. A transplant center, including a kidney transplant... Report and 1-year patient and graft survival data contained in the most recent Scientific Registry...

  20. Increasing spelling achievement: an analysis of treatment procedures utilizing an alternating treatments design.


    Ollendick, T. H.; Matson, J L; Esveldt-Dawson, K; Shapiro, E S


    Two studies which examine the effectiveness of spelling remediation procedures are reported. In both studies, an alternating treatment design was employed. In the first study, positive practice overcorrection plus positive reinforcement was compared to positive practice alone and a no-remediation control condition. In the second study, positive practice plus positive reinforcement was compared to a traditional corrective procedure plus positive reinforcement and a traditional procedure when u...

  1. 12 CFR 24.5 - Public welfare investment after-the-fact notice and prior approval procedures. (United States)


    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Public welfare investment after-the-fact notice... OTHER PUBLIC WELFARE INVESTMENTS § 24.5 Public welfare investment after-the-fact notice and prior approval procedures. (a) After-the-fact notice of public welfare investments. (1) Subject to § 24.4(a),...

  2. Alternative to the bentall procedure for elderly patients with aortic root aneurysms. (United States)

    Bical, Olivier M; Deleuze, Philippe


    We describe an alternative technique to the Bentall procedure for elderly patients with aortic root aneurysms. It is the subcoronary implantation of a Freestyle (Medtronic, Minneapolis, MN) aortic bioprosthesis with interposition of a graft material between the upper part of the Freestyle bioprosthesis and the distal aorta. The technique described avoids the proximal anastomosis of the graft and avoids the coronary reimplantations of the Bentall procedure which are still a potential risk of bleeding particularly in elderly patients.

  3. 75 FR 53371 - Liquefied Natural Gas Facilities: Obtaining Approval of Alternative Vapor-Gas Dispersion Models (United States)


    ... Pipeline and Hazardous Materials Safety Administration Liquefied Natural Gas Facilities: Obtaining Approval... Safety Administration (PHMSA) issues federal safety standards for siting liquefied natural gas (LNG...) NFPA 59A: Standard for the Production, Storage, and Handling of Liquefied Natural Gas. That...

  4. Report on noninvasive prenatal testing: classical and alternative approaches [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Kateryna S. Pantiukh


    Full Text Available Concerns of traditional prenatal aneuploidy testing methods, such as low accuracy of noninvasive and health risks associated with invasive procedures, were overcome with the introduction of novel noninvasive methods based on genetics (NIPT. These were rapidly adopted into clinical practice in many countries after a series of successful trials of various independent submethods. Here we present results of own NIPT trial carried out in Moscow, Russia. 1012 samples were subjected to the method aimed at measuring chromosome coverage by massive parallel sequencing. Two alternative approaches are ascertained: one based on maternal/fetal differential methylation and another based on allelic difference. While the former failed to provide stable results, the latter was found to be promising and worthy of conducting a large-scale trial. One critical point in any NIPT approach is the determination of fetal cell-free DNA fraction, which dictates the reliability of obtained results for a given sample. We show that two different chromosome Y representation measures—by real-time PCR and by whole-genome massive parallel sequencing—are practically interchangeable (r=0.94. We also propose a novel method based on maternal/fetal allelic difference which is applicable in pregnancies with fetuses of either sex. Even in its pilot form it correlates well with chromosome Y coverage estimates (r=0.74 and can be further improved by increasing the number of polymorphisms.

  5. INVO Procedure: Minimally Invasive IVF as an Alternative Treatment Option for Infertile Couples

    Directory of Open Access Journals (Sweden)

    Elkin Lucena


    Full Text Available Intravaginal culture (IVC, also called INVO (intravaginal culture of oocytes, is an assisted reproduction procedure where oocyte fertilization and early embryo development are carried out within a gas permeable air-free plastic device, placed into the maternal vaginal cavity for incubation. In the present study we assessed the outcome of the INVO procedure, using the recently designed INVOcell device, in combination with a mild ovarian stimulation protocol. A total of 125 cycles were performed. On average 6.5 oocytes per cycle were retrieved, and a mean of 4.2 were placed per INVOcell device. The cleavage rate obtained after the INVO culture was 63%. The procedure yielded 40%, 31.2%, and 24% of clinical pregnancy, live birth, and single live birth rates per cycle, respectively. Our results suggest that the INVO procedure is an effective alternative treatment option in assisted reproduction that shows comparable results to those reported for existing IVF techniques.

  6. 49 CFR 173.56 - New explosives-definition and procedures for classification and approval. (United States)


    ... requirements in APA Standard 87-1 (IBR, see § 171.7 of this subchapter); (2) A thermal stability test is... the Associate Administrator following the applicable requirements in APA Standard 87-1, and is... device for which approval is requested conforms to APA Standard 87-1 and that the descriptions...

  7. 46 CFR 160.033-5 - Procedure for approval of mechanical disengaging apparatus. (United States)


    ... plans covering fully the arrangement and construction of the apparatus, together with stress diagrams... plans and upon completion, conduct the tests required by § 160.033-4. (c) At the time that the tests are... approved plans, additional copies shall be submitted at that time. (d) Upon receipt of corrected...

  8. 15 CFR 923.133 - Procedure for conducting continuing reviews of approved State CZM programs. (United States)


    ... will submit a financial assistance application or work program, whichever is applicable, on a timetable... evaluation team indicating that they wish to receive the final findings. Notice of the availability of the... approved CZM program; (B) The management agency is effectively playing a leadership role in coastal...

  9. An Alternative Sorting Procedure for Interactive Group Decision Support Based on the Pseudo-criterion Concept

    Directory of Open Access Journals (Sweden)

    Andrej Bregar


    Full Text Available An original interactive procedure is proposed, which aims at overcoming some of the major weaknesses of existing pseudocriterion based methods for group decision analysis. It refers to absolute judgements of feasible alternatives and is focused on complementary activities of opinion elicitation and robustness analysis. As a foundation, four interdependent principles are introduced – problem localization, interactivity on the basis of progressiveness approach, semiautomatic derivation of criteria weights according to selective effects of veto thresholds, and group consensus seeking. The principles are grounded and realized by appropriate methodological solutions.

  10. Alternative procedure for making a metal suprastructure in a milled bar implant-supported overdenture. (United States)

    Ercoli, C; Graser, G N; Tallents, R H; Hagan, M E


    The predictability of implant-supported prostheses has been established. Although the original Brånemark design has been successfully used in the mandible, esthetic, speech, and hygiene-related problems have been reported in maxillary fixed prostheses. Implant-overdentures can overcome some of the problems encountered in maxillary fixed prostheses. Milled-bar implant-supported overdentures fabricated by electric discharge machining are characterized by stability similar to a fixed prostheses and are removable for hygiene procedures. However, the procedure is costly and requires highly trained technicians. An alternative procedure to produce an accurately fitting metal suprastructure is presented. This procedure does not require additional technical skills and uses instruments and materials that are readily available and relatively inexpensive. The use of simple and easy to replace attachments allows repairs to be performed in the dental office, thus reducing maintenance cost. The overall result is a prosthesis that incorporates the features of a spark erosion overdenture at a fraction of the cost and that is available to a broader patient population.

  11. Alternative procedure for the fabrication of close-spaced sublimated CdTe solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Moutinho, H. R. [National Renewable Energy Laboratory, Golden, Colorado 80401 (United States); Dhere, R. G. [National Renewable Energy Laboratory, Golden, Colorado 80401 (United States); Ballif, C. [National Renewable Energy Laboratory, Golden, Colorado 80401 (United States); Al-Jassim, M. M. [National Renewable Energy Laboratory, Golden, Colorado 80401 (United States); Kazmerski, L. L. [National Renewable Energy Laboratory, Golden, Colorado 80401 (United States)


    We deposited CdTe thin films by close-spaced sublimtation using an alternative procedure, with temperatures about 170 degree sign C lower than the ones used in the standard procedure. These films were used in the fabrication of all thin-film CdTe/CdS solar cells. We treated the cells using the well-established CdCl{sub 2} dipping process as well as a new vapor treatment. The vapor process was more reproducible and easier to control, and it produced the best devices. This process was also much more effective in the recrystallization of the CdTe films. The best device that we produced had an efficiently of 11.6%, close to the 12.3% efficiency of the best device fabricated using the standard process. These results show that the new process has good potential, and besides being an alternative for lower-cost solar cell production, it can also produce high-efficiency devices. (c) 2000 American Vacuum Society.

  12. Alternative complement pathway activation during invasive coronary procedures in acute myocardial infarction and stable angina pectoris. (United States)

    Horváth, Zsófia; Csuka, Dorottya; Vargova, Katarina; Kovács, Andrea; Leé, Sarolta; Varga, Lilian; Préda, István; Tóth Zsámboki, Emese; Prohászka, Zoltán; Kiss, Róbert Gábor


    The effect of invasive percutaneous coronary procedures on complement activation has not been elucidated. We enrolled stable angina patients with elective percutaneous coronary intervention (SA-PCI, n=24), diagnostic coronary angiography (CA, n=52) and 23 patients with ST segment elevation myocardial infarction and primary PCI (STEMI-PCI). Complement activation products (C1rC1sC1inh, C3bBbP and SC5b-9) were measured on admission, 6 and 24h after coronary procedures. The alternative pathway product, C3bBbP significantly and reversibly increased 6h after elective PCI (baseline: 7.81AU/ml, 6h: 16.09AU/ml, 24h: 4.27AU/ml, p<0.01, n=23) and diagnostic angiography (baseline: 6.13AU/ml, 6h: 12.08AU/ml, 24h: 5.4AU/ml, p<0.01, n=52). Six hour C3bBbP values correlated with post-procedural CK, creatinine level and the applied contrast material volume (r=0.41, r=0.4, r=0.3, p<0.05, respectively). In STEMI-PCI, baseline C3bBbP level was higher, compared to SA-PCI or CA patients (11.33AU/ml vs. 7.81AU/ml or 6.13AU/ml, p<0.001). Similarly, the terminal complex (SC5b-9) level was already elevated at baseline compared to SA-PCI group (3.49AU/ml vs. 1.87AU/ml, p=0.011). Complement pathway products did not increase further after primary PCI. Elective coronary procedures induced transient alternative complement pathway activation, influenced by the applied contrast volume. In STEMI, the alternative complement pathway is promptly activated during the atherothrombotic event and PCI itself had no further detectable effect.

  13. European type-approval test procedure for evaporative emissions from passenger cars against real-world mobility data from two Italian provinces. (United States)

    Martini, Giorgio; Paffumi, Elena; De Gennaro, Michele; Mellios, Giorgos


    This paper presents an evaluation of the European type-approval test procedure for evaporative emissions from passenger cars based on real-world mobility data. The study relies on two large databases of driving patterns from conventional fuel vehicles collected by means of on-board GPS systems in the Italian provinces of Modena and Firenze. Approximately 28,000 vehicles were monitored, corresponding to approximately 36 million kilometres over a period of one month. The driving pattern of each vehicle was processed to derive the relation between trip length and parking duration, and the rate of occurrence of parking events against multiple evaporative cycles, defined on the basis of the type-approval test procedure as 12-hour diurnal time windows. These results are used as input for an emission simulation model, which calculates the total evaporative emissions given the characteristics of the evaporative emission control system of the vehicle and the ambient temperature conditions. The results suggest that the evaporative emission control system, fitted to the vehicles from Euro 3 step and optimised for the current type-approval test procedure, could not efficiently work under real-world conditions, resulting in evaporative emissions well above the type-approval limit, especially for small size vehicles and warm climate conditions. This calls for a revision of the type-approval test procedure in order to address real-world evaporative emissions.

  14. On the Physical Problem of Spatial Dimensions: An Alternative Procedure to Stability Arguments

    CERN Document Server

    Caruso, Francisco


    Why is space 3-dimensional? The first answer to this question, entirely based on Physics, was given by Ehrenfest, in 1917, who showed that the stability requirement for $n$-dimensional two-body planetary system very strongly constrains space dimensionality, favoring 3-d. This kind of approach will be generically called "stability postulate" throughout this paper and was shown by Tangherlini, in 1963, to be still valid in the framework of general relativity as well as for quantum mechanical hydrogen atom, giving the same constraint for space-dimensionality. In the present work, before criticizing this methodology, a brief discussion has been introduced, aimed at stressing and clarifying some general physical aspects of the problem of how to determine the number of space dimensions. Then, the epistemological consequences of Ehrenfest's methodology are critically reviewed. An alternative procedure to get at the proper number of dimensions, in which the stability postulate (and the implicit singularities in three...

  15. Transient error or specificity? An alternative to the staggered equivalent split-half procedure. (United States)

    Vautier, Stéphane; Jmel, Saïd


    The data-based partial and complete reliability coefficients defined by G. Becker (2000) in his staggered equivalent split-half procedure (SESHP) were compared with the model-based specificity and consistency reliability coefficients defined by R. Steyer, M. J. Schmitt, and M. Eid (1999) in their latent state-trait model (LSTM). Partial reliability is based on coefficient alpha, which contains transient error. State and trait anxiety, measured using the State-Trait Anxiety Inventory on 2 occasions among French adults, illustrated both approaches. Theoretical and empirical analyses demonstrated that the specificity and consistency coefficients offer a testable alternative to the SESHP coefficients. In addition, dynamics of the state residual variance could be modeled and estimated in LSTM.

  16. Low molecular-weight phenols in Tannat wines made by alternative winemaking procedures. (United States)

    Favre, Guzmán; Peña-Neira, Álvaro; Baldi, Cecilia; Hernández, Natalia; Traverso, Sofía; Gil, Graciela; González-Neves, Gustavo


    Low molecular weight phenols of Tannat red wines produced by Traditional Maceration (TM), Prefermentative Cold Maceration (PCM), Maceration Enzyme (ENZ) and grape-Seed Tannins additions (ST), were performed and discussed. Alternatives to TM increased wine phenolic contents but unequally, ST increased mainly smaller flavans-3-ol, PCM anthocyanins and ENZ proanthocyanidins (up to 2250 mg/L). However low molecular weight flavan-3-ols remained below 9 mg/L in all wines, showing that there is not necessarily a correspondence between wine richness in total tannins and flavan-3-ols contents at low molecular weight. PCM wines had particularly high concentrations of tyrosol and tryptophol, yeast metabolism derived compounds. The use of grape-seed enological tannins did not increase grape seed derived phenolic compounds such as gallic acid. Caftaric acid was found in concentrations much higher than those reported in other grape varieties. Wine phenolic content and composition was considerably affected by the winemaking procedures tested.

  17. 40 CFR 86.162-00 - Approval of alternative air conditioning test simulations and descriptions of AC1 and AC2. (United States)


    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Approval of alternative air conditioning test simulations and descriptions of AC1 and AC2. 86.162-00 Section 86.162-00 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND...

  18. Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals. (United States)

    Beken, Sonja; Kasper, Peter; van der Laan, Jan-Willem

    acceptance of 3R testing approaches, including a process for collection of real-life data (safe harbour). Pathways for regulatory acceptance of 3R testing approaches are depicted and a new procedure for submission and evaluation of a proposal for regulatory acceptance of 3R testing approaches is described.

  19. Video-assisted thoracic surgery for pulmonary sequestration: a safe alternative procedure (United States)

    Wang, Lu-Ming; Cao, Jin-Lin


    Background Pulmonary sequestration (PS), a rare congenital anatomic anomaly of the lung, is usually treated through resection by a conventional thoracotomy procedure. The efficacy and safety of video-assisted thoracic surgery (VATS) in PS treatment has seldom been evaluated. To address this research gap, we assessed the efficacy and safety of VATS in the treatment of PS in a large Chinese cohort. Methods We retrospectively reviewed 58 patients with PS who had undergone surgical resection in our department between January 2003 and April 2014. Of these patients, 42 (72.4%) underwent thoracotomy, and 16 (27.6%) underwent attempted VATS resection. Clinical and demographic data, including patients’ age, sex, complaints, sequestration characteristics, approach and procedures, operative time, resection range, blood loss, drainage volume, chest tube duration, hospital stay, and complications were collected, in addition to short-term follow-up data. Results Of the 58 participating patients, 55 accepted anatomic lobectomy, 2 accepted wedge resection, and 1 accepted left lower lobectomy combined with lingular segmentectomy. All lesions were located in the lower lobe, with 1–4 aberrant arteries, except one right upper lobe sequestration. Three cases (18.8%) in the VATS group were converted to thoracotomy because of dense adhesion (n=1), hilar fusion (n=1), or bleeding (n=1). No significant differences in operative time, postoperative hospital stay, or perioperative complications were observed between the VATS and thoracotomy groups, although the VATS patients had less blood loss (P=0.032), a greater drainage volume (P=0.001), and a longer chest tube duration (P=0.001) than their thoracotomy counterparts. Conclusions VATS is a viable alternative procedure for PS in some patients. Simple sequestration without a thoracic cavity or hilum adhesion is a good indication for VATS resection, particularly for VATS anatomic lobectomy. Thoracic cavity and hilum adhesion remain a

  20. Approval procedures for clinical trials in the field of radiation oncology; Genehmigungsverfahren klinischer Studien im Bereich der Radioonkologie

    Energy Technology Data Exchange (ETDEWEB)

    Simon, Monique; Buettner, Daniel [Deutsches Konsortium fuer Translationale Krebsforschung (DKTK), Dresden (Germany); Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (Germany); Medizinische Fakultaet und Universitaetsklinikum Carl Gustav Carus, Technische Universitaet Dresden, Klinik fuer Strahlentherapie und Radioonkologie und OncoRay - Nationales Zentrum fuer Strahlenforschung in der Onkologie, Dresden (Germany); Habeck, Matthias; Habeck, Uta; Brix, Gunnar [Bundesamt fuer Strahlenschutz (BfS), Fachbereich Strahlenschutz und Gesundheit, Neuherberg (Germany); Krause, Mechthild; Baumann, Michael [Deutsches Konsortium fuer Translationale Krebsforschung (DKTK), Dresden (Germany); Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (Germany); Medizinische Fakultaet und Universitaetsklinikum Carl Gustav Carus, Technische Universitaet Dresden, Klinik fuer Strahlentherapie und Radioonkologie und OncoRay - Nationales Zentrum fuer Strahlenforschung in der Onkologie, Dresden (Germany); Helmholtz-Zentrum Dresden - Rossendorf, Institut fuer Radioonkologie und OncoRay - Nationales Zentrum fuer Strahlenforschung in der Onkologie, Dresden (Germany); Willich, Normann [Universitaetsklinikum Muenster, Klinik fuer Strahlentherapie - Radioonkologie, Muenster (Germany); Wenz, Frederik [Universitaetsmedizin Mannheim, Medizinische Fakultaet Mannheim, Universitaet Heidelberg, Klinik fuer Strahlentherapie und Radioonkologie, Mannheim (Germany); Schmidberger, Heinz [Universitaetsmedizin Mainz, Klinik fuer Radioonkologie und Strahlentherapie, Mainz (Germany); Debus, Juergen [Universitaetsklinikum Heidelberg, Klinik fuer Radioonkologie und Strahlentherapie, Heidelberg (Germany); Noelling, Torsten


    Application of ionizing radiation for the purpose of medical research in Germany needs to be approved by the national authority for radiation protection (Bundesamt fuer Strahlenschutz, BfS). For studies in the field of radiation oncology, differentiation between use of radiation for ''medical care (Heilkunde)'' versus ''medical research'' frequently leads to contradictions. The aim of this article is to provide principle investigators, individuals, and institutions involved in the process, as well as institutional review or ethics committees, with the necessary information for this assessment. Information on the legal frame and the approval procedures are also provided. A workshop was co-organized by the German Society for Radiation Oncology (DEGRO), the Working Party for Radiation Oncology (ARO) of the German Cancer Society (DKG), the German Society for Medical Physics (DGMP), and the German Cancer Consortium (DKTK) in October 2013. This paper summarizes the results of the workshop and the follow-up discussions between the organizers and the BfS. Differentiating between ''Heilkunde'' which does not need to be approved by the BfS and ''medical research'' is whether the specific application of radiation (beam quality, dose, schedule, target volume, etc.) is a clinically established and recognized procedure. This must be answered by the qualified physician(s) (''fachkundiger Arzt'' according to German radiation protection law) in charge of the study and the treatments of the patients within the study, taking into consideration of the best available evidence from clinical studies, guidelines and consensus papers. Among the important parameters for assessment are indication, total dose, and fractionation. Radiation treatments applied outside clinical trials do not require approval by the BfS, even if they are applied within a randomized or nonrandomized clinical trial

  1. Is there a need to re-examine the approval of bismuth shotshell as a non-toxic alternative to lead based on the precautionary principle? (United States)

    Fahey, Nathan S C; Tsuji, Leonard J S


    In 1997, the Canadian Wildlife Service (CWS) approved bismuth shotshell as an alternative to lead. We assessed whether there is a need to re-examine the toxicity of bismuth issue using the initial CWS toxicity guideline criteria. Review of the literature suggests that in the context of the precautionary principle, a re-examination of the approval of bismuth shotshell should be undertaken based on animal health issues, associated deficiencies in the analytical data used in the original assessment, and to a lesser extent, human health concerns.

  2. Alternatives to criminal procedure against juvenile and young adult offenders and alternative to criminal procedure in the cases of domestic violence

    Directory of Open Access Journals (Sweden)

    Cvjetko Božica


    Full Text Available In the paper, the author is analyzing the Act on juvenile courts of the Republic of Croatia, which foresees a broad possibility of implementing the principle of opportunity in the pre-trial, i.e. reinvestigation phase of the procedure in terms of the decision of the public prosecutor about the criminal charge against these persons, including the implementation of particular obligations as informal sanctions. Particular attention is paid to the special obligation called off-court agreement. The aim of the off-court agreement is “reconciliation between the juvenile or young adult offender and the victim of the crime, and establishment of the social peace”. Similar project and the implementation of the principle of opportunity is used in the cases of the criminal offence of domestic violence. The main aim of these obligations is to offer professional assistance to the families which are in crisis and have difficulties related to the violent behavior of one family member - mostly the father. Such an approach is more efficient than the long lasting criminal procedure, testifying and strengthening the crisis in the family. This paper gives also an insight into the legal provisions concerning this measure and its implementation in practice.

  3. 40 CFR Appendix D to Part 63 - Alternative Validation Procedure for EPA Waste and Wastewater Methods (United States)


    ... EPA Waste and Wastewater Methods D Appendix D to Part 63 Protection of Environment ENVIRONMENTAL... Procedure for EPA Waste and Wastewater Methods 1. Applicability This procedure is to be applied exclusively.... For the purposes of this appendix, “waste” means waste and wastewater. 2. Procedure This...

  4. Multivariate classification of animal communication signals: a simulation-based comparison of alternative signal processing procedures using electric fishes. (United States)

    Crampton, William G R; Davis, Justin K; Lovejoy, Nathan R; Pensky, Marianna


    Evolutionary studies of communication can benefit from classification procedures that allow individual animals to be assigned to groups (e.g. species) on the basis of high-dimension data representing their signals. Prior to classification, signals are usually transformed by a signal processing procedure into structural features. Applications of these signal processing procedures to animal communication have been largely restricted to the manual or semi-automated identification of landmark features from graphical representations of signals. Nonetheless, theory predicts that automated time-frequency-based digital signal processing (DSP) procedures can represent signals more efficiently (using fewer features) than can landmark procedures or frequency-based DSP - allowing more accurate classification. Moreover, DSP procedures are objective in that they require little previous knowledge of signal diversity, and are relatively free from potentially ungrounded assumptions of cross-taxon homology. Using a model data set of electric organ discharge waveforms from five sympatric species of the electric fish Gymnotus, we adopted an exhaustive simulation approach to investigate the classificatory performance of different signal processing procedures. We considered a landmark procedure, a frequency-based DSP procedure (the fast Fourier transform), and two kinds of time-frequency-based DSP procedures (a short-time Fourier transform, and several implementations of the discrete wavelet transform -DWT). The features derived from each of these signal processing procedures were then subjected to dimension reduction procedures to separate those features which permit the most effective discrimination among groups of signalers. We considered four alternative dimension reduction methods. Finally, each combination of reduced data was submitted to classification by linear discriminant analysis. Our results support theoretical predictions that time-frequency DSP procedures (especially DWT

  5. 16 CFR 1630.61 - Hide carpets and rugs-alternative washing procedure. (United States)


    ... party has previously established to the satisfaction of the Consumer Product Safety Commission is... procedure. 1630.61 Section 1630.61 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS... washing and drying procedure as shall previously have been found to be equivalent by the Consumer...

  6. 16 CFR 1631.61 - Hide carpets and rugs-alternative washing procedure. (United States)


    ... party has previously established to the satisfaction of the Consumer Product Safety Commission is... procedure. 1631.61 Section 1631.61 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS... washing and drying procedure as shall previously have been found to be equivalent by the Consumer...

  7. Amendment to the agreement between CERN and Ukraine concerning the granting of the status of Associate Member at CERN Extension of the deadline for the notification of the completion of the internal approval procedures of the agreement by Ukraine

    CERN Document Server


    Amendment to the agreement between CERN and Ukraine concerning the granting of the status of Associate Member at CERN Extension of the deadline for the notification of the completion of the internal approval procedures of the agreement by Ukraine

  8. A case report of retrograde laparoscopic Spiegel lobectomy: an alternative surgical procedure

    Institute of Scientific and Technical Information of China (English)

    CAI Xiu-jun; DAI Yi; YU Hong; LIANG Xiao; WANG Yi-fan; ZHOU Wei; PENG Shu-you


    @@ The first laparoscopic hepatectomy case was reportedby Reich et al1 in 1991. Initially the laparoscope was utilized diagnostically for resection and biopsy of superficial liver lesions. Recently due to the technological advancement and instrumental improvement, the laparoscopic hepatic resection procedures have evolved significantly. Among them, the caudate lobectomy is considered to be one of the most challenging surgeries on account of its unique anatomic location in the core of the liver within the abdomen. So far, there are only a few reported laparoscopic caudate lobectomy cases in the literature and the most cases were performed utilizing a traditional procedure.2,3

  9. 7 CFR 932.130 - Public member and alternate public member eligibility requirements and nomination procedures. (United States)


    ... requirements. (1) The public member and alternate public member shall not be a producer, handler, or family... processing of olives; nor shall they be either an officer, director, or employee, or family member of an officer, director, or employee of any firm engaged in such activities. (2) The public member and...

  10. Approved routes and alternative paths: the construction of women's rarity in large accounting firms. Evidence from the Big Four France


    Lupu (ioan), Ioana


    Despite decades of gender-balanced recruitment and clear-cut criteria for promotion based on meritocracy, women in public accounting firms remain proportionally fewer in number in the highest levels of the hierarchy than men. This paper aims to explore the mechanisms fostering women's rarity in top positions within French accounting firms in terms of organizationally constructed approved paths. Drawing on 21 semi-structured interviews with both male and female accountants, the specificities o...

  11. 28 CFR 58.17 - Procedures for denying an application or removing an agency from the approved list, and the... (United States)


    ... credit counseling agency. (b) No administrative review will be granted to any applicant that submitted an... supplemented by, an interim directive, which may immediately remove an agency from the approved list. Such an interim directive may be issued if one or more of the following are specifically found: (1) The agency...

  12. 76 FR 37014 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe... (United States)


    ... language in the Code of Federal Regulations (CFR) at 40 CFR 141.2 (definition of public water system). If... same analytical methodology as EPA Method 557 for the determination of dalapon in drinking water. This action amends the dalapon entry to specify the appropriate methodology for each of these methods....

  13. 78 FR 32558 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe... (United States)


    .... The analytes are identified by comparing the acquired mass spectra and retention times for calibration..., Nitrate, Nitrite, ortho-Phosphate, Chloride, Sulfate. Determination of Anions by Ion Chromatography....

  14. 78 FR 37463 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe... (United States)


    ... 1253-08 Titration. DPD Ferrous 4500-Cl F 4500-Cl F Titrimetric. DPD Colorimetric.... 4500-Cl G 4500-Cl.... Amperometric 4500-Cl E 4500-Cl E Titration (Low level measurement). DPD Ferrous 4500-Cl F 4500-Cl F Titrimetric. DPD Colorimetric.... 4500-Cl G 4500-Cl G Iodometric Electrode 4500-Cl I 4500-Cl I On-line Chlorine...

  15. 75 FR 32295 - Expedited Approval of Alternative Test Procedures for the Analysis of Contaminants Under the Safe... (United States)


    ..., Office of Ground Water and Drinking Water (MS 140), Environmental Protection Agency, 26 West Martin Luther King Drive, Cincinnati, OH 45268; telephone number: (513) 569-7652; e-mail address: smith.glynda... ionization, tandem mass spectrometry (IC-ESI-MS/MS) method for the determination of nine haloacetic...

  16. AMPT-induced monoamine depletion in humans: evaluation of two alternative [{sup 123}I]IBZM SPECT procedures

    Energy Technology Data Exchange (ETDEWEB)

    Boot, Erik [Academic Medical Centre (AMC), University of Amsterdam, Department of Psychiatry, Amsterdam (Netherlands); De Bruggen, Centre for People with Intellectual Disability, Zwammerdam (Netherlands); Booij, Jan [AMC, Department of Nuclear Medicine, Amsterdam (Netherlands); Hasler, Gregor [University Hospital, Department of Psychiatry, Zuerich (Switzerland); Zinkstok, Janneke R.; Haan, Lieuwe de; Linszen, Don H.; Amelsvoort, Therese A. van [Academic Medical Centre (AMC), University of Amsterdam, Department of Psychiatry, Amsterdam (Netherlands)


    Acute monoamine depletion paradigms using alpha-methyl-para-tyrosine (AMPT) combined with single photon emission computed tomography (SPECT) have been used successfully to evaluate disturbances in central dopaminergic neurotransmission. However, severe side effects due to relatively high doses (4,500 to 8,000 mg) of AMPT have been reasons for study withdrawal. Thus, we assessed the effectiveness and tolerability of two alternative procedures, using lower doses of AMPT. Six healthy subjects underwent three measurements of striatal dopamine D{sub 2} receptor (D{sub 2}R)-binding potential (BP{sub ND}) with SPECT and the selective radiolabeled D{sub 2}R antagonist [{sup 123}I]IBZM. All subjects were scanned in the absence of pharmacological intervention (baseline) and after two different depletion procedures. In the first depletion session, over 6 h, subjects were administered 1,500 mg of AMPT before scanning. In the second depletion session, over 25 h, subjects were administered 40 mg AMPT/kg body weight. We also administered the Subjective Well-being Under Neuroleptic Treatment Scale, a self-report instrument designed to measure the subjective experience of patients on neuroleptic medication. We found no change of mean D{sub 2}R BP{sub ND} after the first and short AMPT challenge compared to the baseline. However, we found a significant increase in striatal D{sub 2}R BP{sub ND} binding after the AMPT challenge adjusted for bodyweight compared to both other regimen. Although subjective well-being worsened after the prolonged AMPT challenge, no severe side effects were reported. Our results imply a low-dosage, suitable alternative to the common AMPT procedure. The probability of side effects and study withdrawal can be reduced by this procedure. (orig.)

  17. An Alternative and Rapid Method for the Extraction of Nucleic Acids from Ixodid Ticks by Potassium Acetate Procedure

    Directory of Open Access Journals (Sweden)

    Islay Rodríguez


    Full Text Available Four variants of the potassium acetate procedure for DNA extraction from ixodid ticks at different stage of their life cycles were evaluated and compared with phenol-chloroform and ammonium hydroxide methods. The most rapid and most efficient variant was validated in the DNA extraction procedure from the engorged ticks collected from bovine, canine as well as from house ticks for the screening of Borrelia burgdorferi sensu lato, Anaplasma spp. and Babesia spp. The ammonium hydroxide procedure was used for non-engorged ticks. All the variants were efficient and allowed obtaining PCR-quality material according to the specific amplification of 16S rRNA gene fragment of the original tick. DNA extracted from the ticks under the study was tested by multiplex PCR for the screening of tick-borne pathogens. Anaplasma spp. and Babesia spp. amplification products were obtained from 29/48 extracts. Ammonium hydroxide protocol was not efficient for two extracts. Detection of amplification products from the PCR indicated that DNA had been successfully extracted. The potassium acetate procedure could be an alternative, rapid, and reliable method for DNA extraction from the ixodid ticks, mainly for poorly-resourced laboratories.

  18. Mini-invasive impression techniques in fixed prothesis: an alternative to traditional procedures (United States)



    SUMMARY The object of our work is the illustration of an alternative technique in the impress survey in fixed prosthesis. This method conceived from Doctor Casartelli, allowed us to utilize this technology in the day-to-day activity eliminating also the anaesthetic use, so give the possibility to operate patients with anticoagulant therapy. Moreover the mini-invasive techniques allow a lowering recessions, best tolerability from the patients, less pain and postoperative inflammation, “restitutio ad integrum” of tissue without morphological modifications. PMID:23285382

  19. Multi-response permutation procedure as an alternative to the analysis of variance: an SPSS implementation. (United States)

    Cai, Li


    A permutation test typically requires fewer assumptions than does a comparable parametric counterpart. The multi-response permutation procedure (MRPP) is a class of multivariate permutation tests of group difference useful for the analysis of experimental data. However, psychologists seldom make use of the MRPP in data analysis, in part because the MRPP is not implemented in popular statistical packages that psychologists use. A set of SPSS macros implementing the MRPP test is provided in this article. The use of the macros is illustrated by analyzing example data sets.

  20. Tetanus toxoid purification: chromatographic procedures as an alternative to ammonium-sulphate precipitation. (United States)

    Stojićević, Ivana; Dimitrijević, Ljiljana; Dovezenski, Nebojša; Živković, Irena; Petrušić, Vladimir; Marinković, Emilija; Inić-Kanada, Aleksandra; Stojanović, Marijana


    Given an existing demand to establish a process of tetanus vaccine production in a way that allows its complete validation and standardization, this paper focuses on tetanus toxoid purification step. More precisely, we were looking at a possibility to replace the widely used ammonium-sulphate precipitation by a chromatographic method. Based on the tetanus toxin's biochemical characteristics, we have decided to examine the possibility of tetanus toxoid purification by hydrophobic chromatography, and by chromatographic techniques based on interaction with immobilized metal ions, i.e. chelating chromatography and immobilized metal affinity chromatography. We used samples obtained from differently fragmented crude tetanus toxins by formaldehyde treatment (assigned as TTd-A and TTd-B) as starting material for tetanus toxoid purification. Obtained results imply that purification of tetanus toxoid by hydrophobic chromatography represents a good alternative to ammonium-sulphate precipitation. Tetanus toxoid preparations obtained by hydrophobic chromatography were similar to those obtained by ammonium-sulphate precipitation in respect to yield, purity and immunogenicity. In addition, their immunogenicity was similar to standard tetanus toxoid preparation (NIBSC, Potters Bar, UK). Furthermore, the characteristics of crude tetanus toxin preparations had the lowest impact on the final purification product when hydrophobic chromatography was the applied method of tetanus toxoid purification. On the other hand, purifications of tetanus toxoid by chelating chromatography or immobilized metal affinity chromatography generally resulted in a very low yield due to not satisfactory tetanus toxoid binding to the column, and immunogenicity of the obtained tetanus toxoid-containing preparations was poor.

  1. Assessment of alternate procedures for the seismic analysis of multiply supported piping systems

    Energy Technology Data Exchange (ETDEWEB)

    Subudhi, M.; Bezler, P.


    When response spectrum methods are used in the seismic analysis of piping systems the response due to inertial action, the dynamic response, and the response due to the time varying differential motions of the support points (the pseudo-static response) must be determined. In this study the adequacy and the degree of conservatism associated with the uniform response spectrum method, the center of mass response spectrum method and fourteen variants of the independent response spectrum method to compute the dynamic response and five different methods to compute the pseudo-static response were evaluated. For this purpose a sample of six piping systems, two of which were subjected to thirty-three earthquakes, were studied. For each system and seismic excitation a multiple independent support excitation time history analysis was developed and used to provide a best estimate of true response and to form the basis for comparison. A combination procedure to calculate the total responses is considered as well. Results are presented and compared to the corresponding responses evaluated using the current uniform response spectrum method and the center of mass response spectra approach. Based on the results, recommendations concerning the use of the methods were developed.

  2. Case Report: ALCAPA syndrome: successful repair with an anatomical and physiological alternative surgical technique [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Luis Gustavo Vilá Mollinedo


    Full Text Available Anomalous left coronary artery from the pulmonary artery, or ALCAPA syndrome, is a rare congenital cardiac disease that can cause myocardial infarction, heart failure and even death in paediatric patients. Only few untreated patients survive until adult age. Here we present the case of a 33-year-old female patient with paroxysmal tachycardia, syncope and mild exertional dyspnoea. She was diagnosed with ALCAPA syndrome and underwent surgical correction with an alternative technique of left main coronary artery extension to the aorta.

  3. Alternative procedure for the cold test for soybean seeds Procedimento alternativo para o teste de frio em semente de soja

    Directory of Open Access Journals (Sweden)

    Bruno Guilherme Torres Licursi Vieira


    Full Text Available The growing demand for high quality soybean [Glycine max (L. Merrill] seeds requires a precise seed quality control system from the seed industry. One way to accomplish this is by improving vigor testing. Cold test has been traditionally employed for corn seeds. However, it has also been used for other seed crops such as cotton (Gossypium spp., soybean (Glycine Max, dry bean (Phaseolus vulgaris and pea (Pisum sativum. This study was carried out with the objective of adjusting an alternative procedure for the cold test to determine soybean seed vigor. Six commercial soybean seed lots of the cultivar BRS 133 were used. The physiological potential of the seed lots was evaluated by germination on paper towel and sand box, seedling field emergence, tetrazolium, accelerated aging and electrical conductivity tests. Seed moisture content was also determined. The temperature used for the cold test procedures was 10ºC during five days. Four cold test procedures were evaluated: i plastic boxes with soil; ii rolled paper towel with soil; iii rolled paper towel without soil, and iv an alternative procedure, using rolled paper towel without soil under cold water. A completely randomized experimental design with eight replications was used and the means were compared by the Tukey test (p = 0.05. To verify the dependence between the alternative test and others single linear correlation was used. All cold test procedures had similar coefficients of variation (CV, highlighting that rolled paper towel with soil and the alternative procedure had the best performance, with an average of 94% and 93% normal seedlings and CV of 3.2% and 3.6%, respectively. The alternative procedure has satisfactory results for estimating soybean seed vigor, yielding consistent results compared to the traditional procedure.A crescente demanda por semente de soja [Glycine max (L. Merrill] de alta qualidade tem requerido da indústria de sementes um controle de qualidade mais preciso

  4. Alternative Refractive Surgery Procedures (United States)

    ... to precisely separate a very thin sheet of epithelial tissue from the cornea. This thin sheet is lifted to the side and the cornea is treated as with PRK. Then the thin sheet may be ... the epithelial layer heal. Conductive Keratoplasty (CK) CK is a ...

  5. ProSeal laryngeal mask airway: An alternative to endotracheal intubation in paediatric patients for short duration surgical procedures

    Directory of Open Access Journals (Sweden)

    Jaya Lalwani


    Full Text Available The laryngeal mask airway (LMA is a supraglottic airway management device. The LMA is preferred for airway management in paediatric patients for short duration surgical procedures. The recently introduced ProSeal (PLMA, a modification of Classic LMA, has a gastric drainage tube placed lateral to main airway tube which allows the regurgitated gastric contents to bypass the glottis and prevents the pulmonary aspiration. This study was done to compare the efficacy of ProSeal LMA with an endotracheal tube in paediatric patients with respect to number of attempts for placement of devices, haemodynamic responses and perioperative respiratory complications. Sixty children, ASA I and II, weighing 10-20 kg between 2 and 8 years of age group of either sex undergoing elective ophthalmological and lower abdominal surgeries of 30-60 min duration, randomly divided into two groups of 30 patients each were studied. The number of attempts for endotracheal intubation was less than the placement of PLMA. Haemodynamic responses were significantly higher (P<0.05 after endotracheal intubation as compared to the placement of PLMA. There were no significant differences in mean SpO 2 (% and EtCO 2 levels recorded at different time intervals between the two groups. The incidence of post-operative respiratory complications cough and bronchospasm was higher after extubation than after removal of PLMA. The incidence of soft tissue trauma was noted to be higher for PLMA after its removal. There were no incidences of aspiration and hoarseness/sore throat in either group. It is concluded that ProSeal LMA can be safely considered as a suitable and effective alternative to endotracheal intubation in paediatric patients for short duration surgical procedures.

  6. A proposal for an alternative quality control test procedure for inactivated vaccines against food-and-mouth disease virus. (United States)

    Molin-Capeti, K C; Sepulveda, L; Terra, F; Torres-Pioli, M F; Costa-Casagrande, T; França, S C; Thomaz-Soccol, V


    Foot-and-mouth disease (FMD) control in Brazil includes a strict mandatory vaccination program with vaccines produced in certified laboratories subject to inspection by the Brazilian Ministry of Agriculture, Livestock, and Food Supply (MAPA). The FMD vaccine's potency is tested through antibodies titration against structural viral proteins in sera from cattle that have not had any exposure to food-and-mouth disease virus (FMDV), at 28 days post-vaccination. Biological product testing using large animals is expensive and unwieldy. Thus, alternative testing procedures using laboratory animals have been proposed for quality control of these products. Such biological methods for vaccine evaluation using animals from vivarium facilities can have a significant impact through reduced costs, easier handling, and shorter testing times. The present study was designed to access Balb/C mice's humoral immune responses to a FMDV experimental vaccine, the composition of which contains three virus serotypes of FMDV (O1 Campos, A24 Cruzeiro, and C3 Indaial). Balb/C mice were immunized at doses that were 5% and 10% of the vaccine volume administered in cattle. Immunized mice had their antibody titers probed at 14, 21, and 28 DPV (days post vaccination). The results obtained were compared to those previously known from cattle's immune responses to the FMDV vaccine. An adequate immune response to the vaccine was seen with 10% formulation at 21 DPV. The study results are encouraging and indicate that the mouse model can be used for quality control in experimental vaccine testing.

  7. 40 CFR Appendix A to Subpart Mmmm... - Alternative Capture Efficiency and Destruction Efficiency Measurement and Monitoring Procedures... (United States)


    ... portion of the coating and the efficiency of the capture system. The organic carbon content of the control... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Alternative Capture Efficiency and... and Products Pt. 63, Subpt. MMMM, App. A Appendix A to Subpart MMMM of Part 63—Alternative...

  8. Electronic Approval of Invoices (AEF)

    CERN Multimedia


    With a view to the simplification of administrative procedures, AS and FI Departments have completed the second phase of the new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. Phase II includes handling the electronic approval process of invoices whose amounts do not correspond exactly to those of the associated orders. In such cases, budgetary approval is required for the entire invoiced amount. Further information can be obtained at : Phase II of the procedure will be introduced gradually with effect from April 2004. Finance Department, Accounts Payable Section Tel: 72295 Organisation and Procedures Tel: 75885 Information Technologies Department,...

  9. 9 CFR 147.52 - Approved tests. (United States)


    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Approved tests. 147.52 Section 147.52... Approved Tests § 147.52 Approved tests. (a) The procedures for the bacteriological examination of poultry and poultry environments described in this part are approved tests for use in the NPIP. In...

  10. 40 CFR 136.3 - Identification of test procedures. (United States)


    ....14 3 DCP See footnote 34 37. Nickel—Total,4 mg/L Digestion 4 followed by: AA direct aspiration 36... EPA Method 200.2 or an approved alternate procedure (e.g., CEM microwave digestion, which may be used..., “Precision and Recovery Statements for Methods for Measuring Metals.” 36 Microwave-assisted digestion may...

  11. New alternating direction procedures in finite element analysis based upon EBE approximate factorizations. [element-by-element (United States)

    Hughes, T. J. R.; Winget, J.; Levit, I.; Tezduyar, T. E.


    Element-by-element approximate factorization procedures are proposed for solving the large finite element equation systems which arise in computational mechanics. A variety of techniques are compared on problems of structural mechanics, heat conduction and fluid mechanics. The results obtained suggest considerable potential for the methods described.

  12. Optimal Tableaux-Based Decision Procedure for Testing Satisfiability in the Alternating-Time Temporal Logic ATL+

    DEFF Research Database (Denmark)

    Cerrito, Serenella; David, Amelie; Goranko, Valentin


    We develop a sound, complete and practically implementable tableaux-based decision method for constructive satisfiability testing and model synthesis in the fragment ATL+ of the full Alternating time temporal logic ATL∗. The method extends in an essential way a previously developed tableaux......-based decision method for ATL and works in 2EXPTIME, which is the optimal worst case complexity of the satisfiability problem for ATL+. We also discuss how suitable parameterizations and syntactic restrictions on the class of input ATL+ formulae can reduce the complexity of the satisfiability problem....

  13. Integrating environmental restoration management within DOE using an alternative identification and evaluation procedure: A methodology and a case history

    Energy Technology Data Exchange (ETDEWEB)

    Devaurs, M.; Brooks, D.; Kelly, E.; Wagner, S.; Vocke, R.


    The process of identifying and evaluating alternative corrective measures is a fundamental integrating part of Environmental Restoration (ER) activities. The process used in the Los Alamos National Laboratory (the Laboratory) ER Program is based on principles and tools from multiattribute decision analysis, a well-developed and proven method for evaluating options in decision situations involving multiple objectives, uncertainty, multiple interested stakeholders in the final decision, and the need for technical input from disparate disciplines. The process provides a methodology that has been extensively developed and reviewed over the past five decades; it provides a methodological structure for incorporating the concepts espoused in the streamlined approach as well as more specific guidelines such as data quality objectives (DQOs). The application of this methodology to the ER Program at Los Alamos is described in this paper.

  14. 14 CFR 21.325 - Export airworthiness approvals. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Export airworthiness approvals. 21.325... AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Export Airworthiness Approvals § 21.325 Export airworthiness approvals. (a) Kinds of approvals. (1) Export airworthiness approval of Class I products is...

  15. An alternative procedure for uranium analysis in drinking water using AQUALIX columns: application to varied French bottled waters. (United States)

    Bouvier-Capely, C; Bonthonneau, J P; Dadache, E; Rebière, F


    The general population is chronically exposed to uranium ((234)U, (235)U, and (238)U) and polonium ((210)Po) mainly through day-to-day food and beverage intake. The measurement of these naturally-occurring radionuclides in drinking water is important to assess their health impact. In this work the applicability of calix[6]arene-derivatives columns for uranium analysis in drinking water was investigated. A simple and effective method was proposed on a specific column called AQUALIX, for the separation and preconcentration of U from drinking water. This procedure is suitable for routine analysis and the analysis time is considerably shortened (around 4h) by combining the separation on AQUALIX with fast ICP-MS measurement. This new method was tested on different French bottled waters (still mineral water, sparkling mineral water, and spring water). Then, the case of simultaneous presence of uranium and polonium in water was considered due to interferences in alpha spectrometry measurement. A protocol was proposed using a first usual step of spontaneous deposition of polonium on silver disc in order to separate Po, followed by the uranium extraction on AQUALIX column before alpha spectrometry counting.

  16. Consideration of alternative licensing procedures for vaccines for minor species and minor indications--manufacturers' point of view. (United States)

    de Foucauld, J


    The E.U. authorities, manufacturers and people in the field are well aware of the need for a smoother, less-demanding and more harmonised way of granting marketing authorisations for certain products. The authorities have already made some good proposals and this is a basis for discussion and moving ahead. In addition, most of the actors concerned in this process have already had some good (and bad) experiences on how the current system works (or not) in delivering timely authorisations to answer needs from the field, and this factor will also help. It must be noted that the set goal is quite ambitious. Once an agreement is reached on modified technical and regulatory requirements, it could be requested that both E.U. and national law/guidelines be modified. Clearly this will be a very long process. Ceva's paper focuses on what could be the best use of current E.U. law for the registration of Minor Species and Minor Indications vaccines. Furthermore, based on first-hand experience, we will detail how the law could be applied in practical ways so that most of the needs are answered as soon as possible and with reasonable data package and registration procedures.

  17. Electronic Approval of Invoices (AEF)

    CERN Multimedia


    With a view to the simplification of administrative procedures, AS and FI Divisions have drawn up a new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. This new procedure, in its current phase, will be gradually implemented from 1 November 2003 onwards. For clarification and further information, please see: . Finance Division, Accounts Payable Tel.: 7.22.95

  18. A sentence completion procedure as an alternative to the Autobiographical Memory Test for assessing overgeneral memory in non-clinical populations. (United States)

    Raes, Filip; Hermans, Dirk; Williams, J Mark G; Eelen, Paul


    Overgeneral memory (OGM) has been proposed as a vulnerability factor for depression (Williams et al., 2007) or depressive reactivity to stressful life-events (e.g., Gibbs & Rude, 2004). Traditionally, a cue word procedure known as the Autobiographical Memory Test (AMT; Williams & Broadbent, 1986) is used to assess OGM. Although frequently and validly used in clinical populations, there is evidence suggesting that the AMT is insufficiently sensitive to measure OGM in non-clinical groups. Study 1 evaluated the usefulness of a sentence completion method to assess OGM in non-clinical groups, as an alternative to the AMT. Participants were 197 students who completed the AMT, the Sentence Completion for Events from the Past Test (SCEPT), a depression measure, and visual analogue scales assessing ruminative thinking. Results showed that the mean proportion of overgeneral responses was markedly higher for the SCEPT than for the standard AMT. Also, overgeneral responding on the SCEPT was positively associated to depression scores and depressive rumination scores, whereas overgeneral responding on the AMT was not. Results suggest that the SCEPT, relative to the AMT, is a more sensitive instrument to measure OGM, at least in non-clinical populations. Study 2 further showed that this enhanced sensitivity is most likely due to the omission of the instruction to be specific rather than to the SCEPT's sentence completion format (as opposed to free recall to cue words).

  19. Approval plans issues and innovations

    CERN Document Server

    Katz, Linda S


    How can you, as an acquisition librarians, keep current on the output of hundreds of publishers? The answer, of course, is that you cannot. For over 30 years, approval plans have been used by librarians to acquire current titles, save staff time, and build core collections. Even today, these reasons seem appropriate, as libraries try to maintain up-to-date collections and control personnel and operating budgets. However, as shown in Approval Plans: Issues and Innovations, the use of approval plans is not so simple and straightforward; their use is subject to complex procedures and policies--an

  20. The use of skimmed dried milk as an alternative diluent for the cooling step during the boar sêmen freezing procedure

    Directory of Open Access Journals (Sweden)

    Tatyane Bandeira Barros


    Full Text Available One of the critical points in the cryopreservation process is the use of a proper diluent while lowering the temperature following the resuspension and thawing processes. Here, we tested an alternative diluent for the process of freezing boar semen. We used skimmed dried milk (SDM during the cooling and post-thawed resuspension steps. To do so, we collected semen from 15 Dalland boars using the glovedhand technique, and incubated each ejaculate sample at 30 °C. We then removed two semen aliquots from a pre-dilution. We diluted one of the aliquots in Beltsville thawing solution (BTS - control, and the remaining sample was diluted in SDM. Both aliquots were subsequently held at 30º C for 45 min (1st period of stabilization. At the end of this period, we analysed vigor and motility to determine sperm metabolic activity. We then held the diluted semen at 25° C for 30 min (2nd period of stabilization and at 17° C for 2 h (3rd period stabilization. We centrifuged the semen at 800 × g and 1600 × g at 5º C for 15 min, discarded the supernatant, and resuspended the sperm pellet in 2 mL of the cooling diluent at 5° C for 1h. We again diluted the samples in 2 mL of the freezing diluent, poured them into straws, and cooled and plunged them into liquid N2. The sêmen samples were thawed in a 39º C water bath, and were resuspended in their respective diluents at the same temperature. We determined the following sperm features: vigor, motility, vitality, acrosomal integrity and membrane functionality. During the first phase of temperature cooling (30º C, semen diluted in SDM exhibited a higher vigor (3.4 ± 0.6 and motility (78.6 ± 13.0 than those diluted BTS (vigor: 3.1 ± 0.7; motility: 69.4±14.3. However, after the thawing procedure, the inverse was observed in that: BTS samples exhibited a higher vigor (2.1 ± 0.6 and motility (35.5 ± 21.0 than SDM samples (vigor: 1.7 ± 0.9; motility: 22.8 ± 18.1. Regarding membrane functionality and


    Directory of Open Access Journals (Sweden)

    Jairo Andrés Acosta Rojas


    characteristics which made it appropriate for the intended flow simulation, showing that the procedure used for this purpose constitutes a feasible alternative for the 3D digitizing of complex mechanical parts.

  2. [State of Michigan Teacher Education Manual 1970, Sections I and II--Approval of Teacher Education Institutions and Approval of Teacher Education Programs at Approved Teacher Education Institutions]. (United States)

    Michigan State Dept. of Education, Lansing. Teacher Preparation and Professional Development Services.

    This document presents rules and regulations of the Michigan State Board of Education concerning procedures for the approval of teacher education institutions and teacher education programs. The first section details processes in institutional approval, presenting: (1) legislative authority; (2) characteristics of the Approved Program System; (3)…

  3. 14 CFR 171.25 - Minimum requirements for approval. (United States)


    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES Nondirectional Radio Beacon Facilities... met before the FAA will approve an IFR procedure for a non-Federal, nondirectional radio...

  4. Alternatives procedures for small farming sustainable management of parana pine Mecanismos alternativos para manejo sustentável de pinheiro-do-paraná na pequena propriedade rural

    Directory of Open Access Journals (Sweden)

    Jorge Zbigniew Mazuchowski


    Full Text Available

    After the expansion of agricultural frontier occurred in the southern brazilian region, which brought native forest substitution, new  management and alternatives practices were introduced in order to preserve and stimulate new plantings of the parana pine (Araucaria angustifolia . Alongside, in the last years, silviculturists have been promoting activities of forest development, in special with Pinus, Eucalyptus, Grevillea and bracatinga (Mimosa scabrella species to face wood depletion of native forest species. At the same time, new legal procedures also contributed to reduce new plantings of parana pine  because it tried to enforce simple preservation with high demands and tough inspection measures. Thus, representing 85 % of land structure in the State of Paraná, discouraged - small farmers were looking for to erradicate this species due to legal over regulation. Therefore, to  vercome this situation, mechanisms were offered to the silviculture management of Brazilian pine which were based in two central points tupgrading the existing laws and to incentive new plantations, specially in the areas set aside for environmental protection called of "Reserva Legal". In this way, the Extension Service (Emater tried to help this situation with the following prescription: technology diffusion; rewards to stimulate forest producers in the municipality; and formation of farmers groups to collect, select and to sell pine seeds.

    Em substituição às florestas nativas, pela abertura de fronteira agrícola, práticas agropecuárias alternativas foram introduzidas nas propriedades rurais com pinheiro-do-paraná (Araucaria angustifolia (Bert. O. Kunt. Porém, nos últimos anos, a silvicultura tem  promovido o desenvolvimento de atividades ligadas às madeiras de pínus, eucalipto, grevílea e bracatinga frente à exaustão de madeira oriunda de espécies florestais nativas, na geração de recursos no meio

  5. 33 CFR 115.70 - Advance approval of bridges. (United States)


    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance approval of bridges. 115... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.70 Advance approval of bridges. (a) The General Bridge Act of 1946 requires the approval of the location and plans of bridges...

  6. Drugs Approved for Melanoma (United States)

    ... Ask about Your Treatment Research Drugs Approved for Melanoma This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Melanoma Aldesleukin Cobimetinib Cotellic (Cobimetinib) Dabrafenib Dacarbazine DTIC-Dome ( ...

  7. Alternative soaking media for the FDA procedure in the detection of salmonella from tomatoes and spinach leaf using phage magnetoelastic biosensors (United States)

    Chen, I.-Hsuan; Hu, Jiajia; Wang, Fengen; Horikawa, Shin; Barbaree, James M.; Chin, Bryan A.


    Efforts were made to incorporate the phage Magnetoelastic (ME) biosensor in FDA's Spinach Soaking procedures according to FDA 2015 BAM method. Three soaking materials (Lactose broth, LB broth, and Peptone water) and various soaking times were investigated. Using merely 100 Salmonella cells spiked on the produce surfaces, the phage biosensors detected Salmonella within 5 hours when soaking tomatoes in LB broth as opposed to taking up to 24 hours. Salmonella was detected on spinach leaves within 7 hours. These phage ME biosensors provide a promising rapid detection platform using LB broth in FDA's soaking procedures while shortening the incubation period.

  8. A Systematic Review of Consent Procedures, Participation Rates, and Main Findings of Health-Related Research in Alternative High Schools from 2010 to 2015 (United States)

    Johnson, Karen E.; Morris, Marian; Rew, Lynn; Simonton, Amanda J.


    There is a well-established link between educational attainment and health. Alternative high schools (AHSs) serve students who are at risk for school dropout. Health-related research conducted in AHSs has been sparse. Achieving high participation rates is critical to producing generalizable results and can be challenging in research with…

  9. Pretreatment of refinery waste water by wet oxidation. LOPROX {sup registered} procedure: Alternative treatment of sulfidic waste lyes by wet oxidation; Vorbehandlung von Raffinerieabwasser durch Nassoxidation. LOPROX {sup registered} -Verfahren: Alternative Behandlung von sulfidischen Ablaugen durch Nassoxidation

    Energy Technology Data Exchange (ETDEWEB)

    Leonhaeuser, Johannes; Weissenberg, Dirk; Birkenbeul, Udo [Bayer Technology Services GmbH (BTS), Leverkusen (Germany). Technology Development and Engineering; Bloecher, Christoph [Currenta (Germany)


    The authors of the contribution under consideration report on the treatment of refinery wastewater by means of the wet oxidation. The authors present the LOPROX {sup registered} method as an alternative treatment of sulfidic waste lyes. This method can not only treat successfully organic polluted wastewater from the chemical industry, but also various waste lyes from refinery processes. Based on a customer-specific process optimization in pilot scale, a cost-effective treatment can be achieved.

  10. Shut up and pet me! Domestic dogs (Canis lupus familiaris) prefer petting to vocal praise in concurrent and single-alternative choice procedures. (United States)

    Feuerbacher, Erica N; Wynne, Clive D L


    The nature of the interactions that maintain the social behavior of dogs toward humans and which interactions dogs prefer have not been thoroughly investigated. We focused here on dogs' preference for petting and vocal praise, and the influence that familiarity (owner vs. stranger) has on that preference. We first used concurrent choice to evaluate dogs' preference for petting or vocal praise and measured the initial choice, the time spent with each alternative, and the number of within-session alternations. We assessed dogs' preference for petting or vocal praise in (1) shelter dogs, (2) owned dogs with strangers providing both interactions, and (3) owned dogs with the dog's owner providing the interactions. Across all experimental groups, dogs preferred petting to vocal praise. We next assessed time spent with each alternative when only one alternative was available at a time in shelter dogs and owned dogs (Experiment 2). Shelter dogs were tested with a stranger and owned dogs were tested with their owners providing the interaction. Dogs alternated between petting and vocal praise, vocal praise and no interaction, or received only petting for eight 3-min sessions of each comparison. Both shelter and owned dogs spent significantly longer in proximity to the experimenter when the interaction was petting compared to vocal praise. Vocal praise produced as little proximity-seeking behavior as did no interaction. Additionally, dogs did not show any sign of satiation with petting across all eight sessions. Overall, petting seems to be an important interaction between dogs and humans that might maintain inter-specific social behavior but vocal praise likely has to be specifically conditioned. This article is part of a Special Issue entitled: Canine Behavior.

  11. Additional safety risk to exceptionally approved drugs in Europe?

    NARCIS (Netherlands)

    Arnardottir, Arna H.; Haaijer-Ruskamp, Flora M.; Straus, Sabine M. J.; Eichler, Hans-Georg; de Graeff, Pieter A.; Mol, Peter G. M.


    AIMS Regulatory requirements for new drugs have increased. Special approval procedures with priority assessment are possible for drugs with clear 'unmet medical need'. We question whether these Exceptional Circumstances (EC) or Conditional Approval (CA) procedures have led to a higher probability of

  12. 14 CFR 121.315 - Cockpit check procedure. (United States)


    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Cockpit check procedure. 121.315 Section... Cockpit check procedure. (a) Each certificate holder shall provide an approved cockpit check procedure for... for items to be checked. (c) The approved procedures must be readily usable in the cockpit of...

  13. 14 CFR 183.53 - Procedures manual. (United States)


    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Procedures manual. 183.53 Section 183.53... manual. No ODA Letter of Designation may be issued before the Administrator approves an applicant's procedures manual. The approved manual must: (a) Be available to each member of the ODA Unit; (b) Include...

  14. A review of mammalian carcinogenicity study design and potential effects of alternate test procedures on the safety evaluation of food ingredients. (United States)

    Hayes, A W; Dayan, A D; Hall, W C; Kodell, R L; Williams, G M; Waddell, W D; Slesinski, R S; Kruger, C L


    of test procedures, dose selection, histopathology procedures, application of historical control data, statistical evaluations and whether statistical extrapolations are supported by, or are beyond the limits of, the data generated. Without due consideration, there can be result conflicting data interpretations and uncertainty about the relevance of a study's results to human risk. This paper discusses the critical elements of rodent (rat) carcinogenicity studies, particularly with respect to the study of food ingredients. It also highlights study practices and procedures that can detract from the appropriate evaluation of human relevance of results, indicating the importance of adherence to international consensus protocols, such as those detailed by OECD.

  15. Technical Note: Higher-order statistical moments and a procedure that detects potentially anomalous years as two alternative methods describing alterations in continuous environmental data (United States)

    Arismendi, I.; Johnson, S. L.; Dunham, J. B.


    Statistics of central tendency and dispersion may not capture relevant or desired characteristics of the distribution of continuous phenomena and, thus, they may not adequately describe temporal patterns of change. Here, we present two methodological approaches that can help to identify temporal changes in environmental regimes. First, we use higher-order statistical moments (skewness and kurtosis) to examine potential changes of empirical distributions at decadal extents. Second, we adapt a statistical procedure combining a non-metric multidimensional scaling technique and higher density region plots to detect potentially anomalous years. We illustrate the use of these approaches by examining long-term stream temperature data from minimally and highly human-influenced streams. In particular, we contrast predictions about thermal regime responses to changing climates and human-related water uses. Using these methods, we effectively diagnose years with unusual thermal variability and patterns in variability through time, as well as spatial variability linked to regional and local factors that influence stream temperature. Our findings highlight the complexity of responses of thermal regimes of streams and reveal their differential vulnerability to climate warming and human-related water uses. The two approaches presented here can be applied with a variety of other continuous phenomena to address historical changes, extreme events, and their associated ecological responses.

  16. A comunicação alternativa como procedimento de desenvolvimento de habilidades comunicativas Augmentative and alternative communication as a procedure for developing communication skills

    Directory of Open Access Journals (Sweden)

    Cândice Lima Moreschi


    Full Text Available O estudo teve como objetivo planejar, aplicar e avaliar os efeitos de um programa de intervenção sobre Comunicação Alternativa para o desenvolvimento de habilidades comunicativas de uma adolescente com deficiência intelectual. Participaram da pesquisa uma menina de 14 anos, com diagnóstico de deficiência intelectual e déficits na comunicação verbal, a mãe e a educadora da adolescente. Para verificar os efeitos da intervenção, foi utilizado o delineamento de sujeito único, do modelo AB. Nos resultados da avaliação pragmática, por meio do teste ABFW, ao comparamos o desempenho da participante antes e após a intervenção, verificou-se um aumento dos atos comunicativos e melhora significativa do conteúdo dialógico. Na Avaliação de Linguagem Receptiva e Expressiva, a participante obteve êxito em todos os itens da seção não verbal (pré e pós teste. Na seção verbal, após o processo de intervenção, a participante adquiriu a habilidade de imitar sons e iniciar diálogos. Na análise dos questionários aplicados aos pais e professora da adolescente, foi possível perceber alguns pontos de divergência quanto a habilidade em comunicar desejos e sentimentos e na execução de ordens dadas. Com o início do processo de intervenção, e com a introdução do Sistema de Comunicação Alternativa - PECS verificou-se que a participante passou a utilizar as figuras pictográficas como recurso comunicativo durante situações da vida diária. Embora a participante apresentasse comunicação verbal antes do início do processo de intervenção, essa comunicação não era eficiente durante as interações. Assim, a participante utilizou o Sistema de Comunicação como alternativa para aprimorar suas habilidades linguísticas, além de complementar sua comunicação oral.The study was designed to plan, implement and evaluate the effects of an Alternative Communication intervention program for developing the communication skills of a

  17. Post-Approval Studies (United States)

    U.S. Department of Health & Human Services — The CDRH Post-Approval Studies Program encompasses design, tracking, oversight, and review responsibilities for studies mandated as a condition of approval of a...

  18. A Study of Approval Plans and the Government’s Ability to Contract for Them under the Federal Acquisition Regulation (FAR) (United States)


    along with procedural methods for implementing approval plans under current Department of Defense regulations. NTFIS GRASA DTIC TAB0 Just Ifced1 By...with loshiba MAP 1988 Corporation or Kongsberg Vapenfabrikk.- OfferorS Representation 52.225-17027 Restriction on Contracting with Toshiba MAR 1988... Corporation or Kongsberg Vapenfabrikk 52.227-7031( P Data Requirements APR 1912 52-232-7007( P Progress Payments - Alternate I OCT 1916 52.233-100( P

  19. Waste Feed Delivery Environmental Permits and Approvals Plan

    Energy Technology Data Exchange (ETDEWEB)



    This plan describes the environmental permits approvals, and other requirements that may affect establishment of a waste feed delivery system for the Hanford Site's River Protection Project. This plan identifies and screens environmental standards for potential applicability, outlines alternatives for satisfying applicable standards, and describes preferred permitting and approval approaches.

  20. Alternative energies; Energies alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Bonal, J.; Rossetti, P


    The earth took millions years to made the petroleum, the gas the coal and the uranium. Only a few centuries will be needed to exhaust these fossil fuels and some years to reach expensive prices. Will the wold continue on this way of energy compulsive consumption? The renewable energies and some citizen attitudes are sufficient to break this spiral. This book proposes to discuss these alternative energies. It shows that this attitude must be supported by the government. It takes stock on the more recent information concerning the renewable energies. it develops three main points: the electricity storage, the housing and the transports. (A.L.B.)

  1. Study on the In-House Validation Procedure of Alternative Method for Salmonella spp.%沙门氏菌可替代方法实验室内验证程序研究

    Institute of Scientific and Technical Information of China (English)

    马云; 王明鑑; 贾臻; 罗世芝; 王海霞; 郭君; 姚广红; 王茸; 贾俊涛


    In order to show the detailed procedure of in-house validation of the alternative methods for Salmonella spp., this study was conducted with SureTect real-time PCR Test for Salmonella spp. as an example and the reference method according to ISO 16140:2003/Amd:2011 Microbiology of food and animal feeding stuffs-Protocol for the validation of alternative method. The following performance indices were obtained:①The Relative Accuracy, Relative Specificity and Relative Sensitivity;②Relative Detection Level;③Inclusivity and Exclusivity. Statistical testings proved that there were no significant differences between the two methods for Relative Accuracy, Relative Specificity, Relative Sensitivity and Relative Detection Level respectively. As to the inclusivity and exclusivity, the results of the strains were almost congruent. The validation procedure mentioned above revealed that specific procedure should be implemented when in-house validation was launched and the procedure in this study could assess the performance of the alternative methods for Salmonella spp. reasonably. Moreover, this in-house validation can be used as a paradigm for similar work of microbial tests.%为探索沙门氏菌可替代方法实验室内验证的具体程序,依据ISO 16140:2003/Amd 1:2011《食品和动物饲料微生物学-可替代方法的验证方案》,以赛默科技SureTect沙门氏菌实时PCR检测方法为例,对照参照方法进行了实验室内验证。所涉及的性能指标包括:①相对准确性、相对特异性和相对灵敏度;②相对检测限;③包含性和排他性。统计检验表明,该方法与参照方法在相对准确性、相对特异性和相对灵敏度方面无显著性差异,两种方法的相对检测限也无显著性差异。两种方法包含性和排他性检测结果基本一致。上述验证程序表明,检测方法的实验室内验证需遵循特定的程序,该验证程序可科学评价沙门氏菌可替代

  2. 49 CFR 107.403 - Designation of approval agencies. (United States)


    ... 49 Transportation 2 2010-10-01 2010-10-01 false Designation of approval agencies. 107.403 Section 107.403 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... MATERIALS PROGRAM PROCEDURES Designation of Approval and Certification Agencies § 107.403 Designation...

  3. 48 CFR 232.409-1 - Recommendation for approval. (United States)


    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Recommendation for approval. 232.409-1 Section 232.409-1 Federal Acquisition Regulations System DEFENSE ACQUISITION... for Non-Commercial Items 232.409-1 Recommendation for approval. Follow the procedures at PGI...

  4. For the approval process of GMOs: The Japanese case

    NARCIS (Netherlands)

    Ebata, A.; Punt, M.J.; Wesseler, J.H.H.


    This article reviews the approval process of genetically modified organisms (GMOs) in Japan. The purpose of this review is to explain the Japanese safety approval procedures for food, feed, and imported GMOs and place it in an international context through a comparison with the United States and the

  5. 14 CFR 21.8 - Approval of articles. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  6. Alternative additives; Alternative additiver

    Energy Technology Data Exchange (ETDEWEB)


    In this project a number of industrial and agricultural waste products have been characterised and evaluated in terms of alkali-getter performance. The intended use is for biomass-fired power stations aiming at reducing corrosion or slagging related problems. The following products have been obtained, characterised and evaluated: 1) Brewery draff 2) Danish de-gassed manure 3) Paper sludge 4) Moulding sand 5) Spent bleaching earth 6) Anorthosite 7) Sand 8) Clay-sludge. Most of the above alternative additive candidates are deemed unsuitable due to insufficient chemical effect and/or expensive requirements for pre-treatment (such as drying and transportation). 3 products were selected for full-scale testing: de-gassed manure, spent bleaching earth and clay slugde. The full scale tests were undertaken at the biomass-fired power stations in Koege, Slagelse and Ensted. Spent bleaching earth (SBE) and clay sludge were the only tested additive candidates that had a proven ability to react with KCl, to thereby reduce Cl-concentrations in deposits, and reduce the deposit flux to superheater tubes. Their performance was shown to nearly as good as commercial additives. De-gassed manure, however, did not evaluate positively due to inhibiting effects of Ca in the manure. Furthermore, de-gassed manure has a high concentration of heavy metals, which imposes a financial burden with regard to proper disposal of the ash by-products. Clay-sludge is a wet clay slurring, and drying and transportation of this product entails substantial costs. Spent bleaching does not require much pre-treatment and is therefore the most promising alternative additive. On the other hand, bleaching earth contains residual plant oil which means that a range of legislation relating to waste combustion comes into play. Not least a waste combustion fee of 330 DKK/tonne. For all alternative (and commercial) additives disposal costs of the increase ash by-products represents a significant cost. This is

  7. National Ignition Facility (NIF) operations procedures plan

    Energy Technology Data Exchange (ETDEWEB)

    Mantrom, D.


    The purpose of this Operations Procedures Plan is to establish a standard procedure which outlines how NIF Operations procedures will be developed (i.e , written, edited, reviewed, approved, published, revised) and accessed by the NIF Operations staff who must use procedures in order to accomplish their tasks. In addition, this Plan is designed to provide a guide to the NIF Project staff to assist them in planning and writing procedures. Also, resource and scheduling information is provided.

  8. A Systematic Approach to Alternative Medical Procedures (United States)


    restriction. Neural cells with higher levels of UCP4 exhibit reduced production of reactive oxygen species (ROS) and decreased mito- chondrial calcium...accumulation; that is, the UCP4-mediated shift in energy metabolism reduces ROS production and increases the resistance of neurons to oxidative and...One potent source of sulfora - phane is broccoli sprouts, in which the sulforaphane concentration is more than an order of magnitude higher than in

  9. 14 CFR 21.441 - Procedure manual. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Procedure manual. 21.441 Section 21.441... manual. (a) No DAS may exercise any authority under this subpart unless it submits, and obtains approval of, a procedure manual containing— (1) The procedures for issuing STCs; and (2) The names,...

  10. 24 CFR 248.223 - Alternative State strategy. (United States)


    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Alternative State strategy. 248.223... Preservation Act of 1987 § 248.223 Alternative State strategy. (a) The Commissioner may approve a State strategy providing for State approval of plans of action that involve termination of low...

  11. 46 CFR 249.6 - Application procedures. (United States)


    ... OPERATORS APPROVAL OF UNDERWRITERS FOR MARINE HULL INSURANCE § 249.6 Application procedures. (a) MARAD may grant specific approval for underwriters described in § 249.5(c) to participate in the writing of marine... submissions are considered inadequate; (2) A comprehensive description and English language version of...

  12. Update on Nonsurgical Lung Volume Reduction Procedures

    Directory of Open Access Journals (Sweden)

    J. Alberto Neder


    Full Text Available There has been a surge of interest in endoscopic lung volume reduction (ELVR strategies for advanced COPD. Valve implants, coil implants, biological LVR (BioLVR, bronchial thermal vapour ablation, and airway stents are used to induce lung deflation with the ultimate goal of improving respiratory mechanics and chronic dyspnea. Patients presenting with severe air trapping (e.g., inspiratory capacity/total lung capacity (TLC 225% predicted and thoracic hyperinflation (TLC > 150% predicted have the greatest potential to derive benefit from ELVR procedures. Pre-LVRS or ELVR assessment should ideally include cardiological evaluation, high resolution CT scan, ventilation and perfusion scintigraphy, full pulmonary function tests, and cardiopulmonary exercise testing. ELVR procedures are currently available in selected Canadian research centers as part of ethically approved clinical trials. If a decision is made to offer an ELVR procedure, one-way valves are the first option in the presence of complete lobar exclusion and no significant collateral ventilation. When the fissure is not complete, when collateral ventilation is evident in heterogeneous emphysema or when emphysema is homogeneous, coil implants or BioLVR (in that order are the next logical alternatives.

  13. Drugs Approved for Thyroid Cancer (United States)

    ... Ask about Your Treatment Research Drugs Approved for Thyroid Cancer This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Thyroid Cancer Cabozantinib-S-Malate Caprelsa (Vandetanib) Cometriq (Cabozantinib-S-Malate) Doxorubicin ...

  14. Drugs Approved for Lung Cancer (United States)

    ... Ask about Your Treatment Research Drugs Approved for Lung Cancer This page lists cancer drugs approved by the ... listed here. Drugs Approved for Non-Small Cell Lung Cancer Abitrexate (Methotrexate) Abraxane (Paclitaxel Albumin-stabilized Nanoparticle Formulation) ...

  15. Comparison of 3M Petrifilm Aerobic Count Plates to standard plating methodology for use with AOAC antimicrobial efficacy methods 955.14, 955.15, 964.02, and 966.04 as an alternative enumeration procedure: collaborative study. (United States)

    Nelson, Maria T; LaBudde, Robert A; Tomasino, Stephen F; Pines, Rebecca M


    A multilaboratory study was conducted to determine the equivalence of the 3M Petrifilm Aerobic Count Plate and standard plating methodology for measuring viable bacteria and spores recovered from hard-surface carriers (stainless steel and porcelain), also known as "control carrier counts," used in AOAC antimicrobial efficacy test methods. Six laboratories participated in the study in which carriers inoculated with Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella enterica, and spores of Bacillus subtilis were evaluated using 3M Petrifilm Aerobic Count (AC) plates and standard plating side-by-side. The data were analyzed using a matched-pair t-test to determine the between-method effect with confidence intervals. For all test organisms pooled across all laboratories, the mean difference in log10 concentration between the standard plate count method and 3M Petrifilm AC Plates was -0.012, with a 95% confidence interval of (-0.090, +0.066), which was well within the -0.5, +0.5 interval established as the acceptance criterion. The between-carrier SD averaged 0.139; the between-replicate SD was 0.050. The carrier reproducibility, given that a single replicate per carrier is done, was estimated to be 0.148. Although differences were seen in the final concentrations of the test organisms among laboratories, there were no statistical differences between the enumeration methods. Based on the results from this study, 3M Petrifilm AC Plates are equivalent to standard plating methodology and can be used as an alternative procedure for the enumeration of test organisms used in AOAC Methods 955.14, 955.15, 964.02, and 966.04.

  16. Drugs Approved for Retinoblastoma (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for retinoblastoma. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  17. Drugs Approved for Neuroblastoma (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for neuroblastoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  18. FWS Approved Acquisition Boundaries (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North America,...

  19. Premarket Approvals (PMA) (United States)

    U.S. Department of Health & Human Services — Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An...

  20. FWS Approved Acquisition Boundaries (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North...

  1. 40 CFR 52.138 - Conformity procedures. (United States)


    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Conformity procedures. 52.138 Section...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.138 Conformity procedures. (a) Purpose. The... plans for metropolitan transportation planning organizations (MPOs) to use when determining...

  2. Electronic Procedures for Medical Operations Project (United States)

    National Aeronautics and Space Administration — We propose an alternative to using Microsoft Word for representing medical procedures that will make the procedures easier to construct and maintain, particularly...

  3. Pembrolizumab: first global approval. (United States)

    Poole, Raewyn M


    Pembrolizumab [Keytruda(®) (US)], a humanized monoclonal antibody against the programmed death receptor-1 (PD-1) protein, has been developed by Merck & Co for the treatment of cancer. Pembrolizumab has received its first global approval for the treatment of advanced, unresectable or metastatic malignant melanoma in the US, for use in patients with disease progression after prior treatment with ipilimumab and, for BRAF V600 mutation-positive patients, a BRAF inhibitor. It is the first anti-PD-1 therapy to receive regulatory approval in the US, and is currently under regulatory review in the EU. This article summarizes the milestones in the development of pembrolizumab leading to this first approval for the treatment of malignant melanoma.

  4. Pomalidomide: first global approval. (United States)

    Elkinson, Shelley; McCormack, Paul L


    Pomalidomide (Pomalyst(®)) is a small molecule analogue of thalidomide under development with Celgene Corporation for the oral treatment of haematological and connective tissue diseases. Pomalidomide has been approved in the USA and is awaiting approval in the EU for use with low-dose dexamethasone for the treatment of relapsed and refractory multiple myeloma that has progressed following at least two prior therapies, including lenalidomide and bortezomib. The efficacy and safety of pomalidomide as monotherapy in patients with relapsed and refractory multiple myeloma has also been evaluated in a phase III trial. The agent is in phase III clinical development for the treatment of myelofibrosis and in phase II development for systemic sclerosis. Pomalidomide is also being investigated in patients with amyloidosis, prostate cancer, small cell lung cancer, pancreatic cancer, graft-versus-host disease, and Waldenstrom's macroglobulinaemia. This article summarizes the milestones in the development of pomalidomide leading to this first global approval for relapsed and refractory multiple myeloma.

  5. Apremilast: first global approval. (United States)

    Poole, Raewyn M; Ballantyne, Anita D


    Apremilast (Otezla(®)), an oral small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4), is under development with Celgene Corporation for the treatment of psoriatic arthritis, psoriasis, ankylosing spondylitis, Behçet's syndrome, atopic dermatitis, and rheumatoid arthritis. Apremilast is indicated for the treatment of active psoriatic arthritis in adults. Apremilast has received its first global approval for this indication in the USA. Regulatory submissions for approval in this indication are under review in Canada and Europe. Regulatory filings have also been submitted for apremilast in the treatment of plaque psoriasis in the USA and Europe. This article summarizes the milestones in the development of apremilast leading to its first approval for the treatment of psoriatic arthritis.

  6. Innovations in Arizona's Accountability Policies and Frameworks for Alternative Schools (United States)

    Schlessman, Amy


    This study presents Arizona's innovations in academic accountability policy and academic accountability frameworks for alternative schools. A timeline of statutes and regulations including the State Board of Education approved alternative school definition provides Arizona's context for alternative school accountability policy and frameworks.…

  7. 30 CFR 75.1507 - Emergency Response Plan; refuge alternatives. (United States)


    ....1507 Emergency Response Plan; refuge alternatives. (a) The Emergency Response Plan (ERP) shall include... request and the District Manager may approve an alternative location in the ERP if mining involves two-entry systems or yield pillars in a longwall that would prohibit locating the refuge alternative out...

  8. Alternative metrics (United States)


    As the old 'publish or perish' adage is brought into question, additional research-impact indices, known as altmetrics, are offering new evaluation alternatives. But such metrics may need to adjust to the evolution of science publishing.

  9. Alternative Green Solvents Project (United States)

    Maloney, Phillip R.


    Necessary for safe and proper functioning of equipment. Mainly halogenated solvents. Tetrachloride, Trichloroethylene (TCE), CFC-113. No longer used due to regulatory/safety concerns. Precision Cleaning at KSC: Small % of total parts. Used for liquid oxygen (LOX) systems. Dual solvent process. Vertrel MCA (decafluoropentane (DFP) and trons-dichloroethylene) HFE-7100. DFP has long term environmental concerns. Project Goals: a) Identify potential replacements. b) 22 wet chemical processes. c) 3 alternative processes. d) Develop test procedures. e) Contamination and cleaning. f) Analysis. g) Use results to recommend alternative processes. Conclusions: a) No alternative matched Vertrel in this study. b) No clear second place solvent. c) Hydrocarbons- easy; Fluorinated greases- difficult. d) Fluorinated component may be needed in replacement solvent. e) Process may need to make up for shortcoming of the solvent. f) Plasma and SCC02 warrant further testing.

  10. 76 FR 38741 - Tenth Meeting: RTCA Special Committee 221: Aircraft Secondary Barriers and Alternative Flight... (United States)


    ... Alternative Flight Deck Security Procedures AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 221 meeting: Aircraft Secondary Barriers and Alternative Flight Deck... Special Committee 221: Aircraft Secondary Barriers and Alternative Flight Deck Security Procedures....

  11. 75 FR 9016 - Fifth Meeting: RTCA Special Committee 221: Aircraft Secondary Barriers and Alternative Flight... (United States)


    ... Alternative Flight Deck Security Procedures AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 221 meeting: Aircraft Secondary Barriers and Alternative Flight Deck... Special Committee 221: Aircraft Secondary Barriers and Alternative Flight Deck Security Procedures....

  12. FDA Approval for Imiquimod (United States)

    On July 15, 2004, the U.S. Food and Drug Administration (FDA) announced the approval of a new indication for Aldara® (imiquimod) topical cream for the treatment of superficial basal cell carcinoma (sBCC), a type of skin cancer.

  13. Heartland Winthrop Approval (United States)

    This May 19, 2016 letter from EPA approves the petition from Heartland Corn Products regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS program.

  14. FHR Iowa Falls Approval (United States)

    This October 22, 2015, letter from EPA approves the petition from Flint Hills Resources, LLC, regarding non-grandfathered ethanol produced through the FHR Iowa Falls Process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the R

  15. Magnetostrictive Alternator (United States)

    Dyson, Rodger; Bruder, Geoffrey


    This innovation replaces the linear alternator presently used in Stirling engines with a continuous-gradient, impedance-matched, oscillating magnetostrictive transducer that eliminates all moving parts via compression, maintains high efficiency, costs less to manufacture, reduces mass, and eliminates the need for a bearing system. The key components of this new technology are the use of stacked magnetostrictive materials, such as Terfenol-D, under a biased magnetic and stress-induced compression, continuous-gradient impedance-matching material, coils, force-focusing metallic structure, and supports. The acoustic energy from the engine travels through an impedancematching layer that is physically connected to the magnetostrictive mass. Compression bolts keep the structure under compressive strain, allowing for the micron-scale compression of the magnetostrictive material and eliminating the need for bearings. The relatively large millimeter displacement of the pressure side of the impedance-matching material is reduced to micron motion, and undergoes stress amplification at the magnetostrictive interface. The alternating compression and expansion of the magnetostrictive material creates an alternating magnetic field that then induces an electric current in a coil that is wound around the stack. This produces electrical power from the acoustic pressure wave and, if the resonant frequency is tuned to match the engine, can replace the linear alternator that is commonly used.

  16. Growing Alternatives

    DEFF Research Database (Denmark)

    Bagger-Petersen, Mai Corlin


    From 2014, Anhui Province will pilot a reform of the residential land market in China, thus integrating rural Anhui in the national housing market. In contrast, artist and activist Ou Ning has proposed the Bishan time money currency, intending to establish an alternative economic circuit in Bishan...

  17. Alternative Treatments (United States)

    ... triglyceride (fat) produced by processing coconut oil or palm kernel oil. The body breaks down caprylic acid into substances called “ketone bodies.” The theory behind Axona is that the ketone bodies derived from caprylic acid may provide an alternative energy source for brain cells that have lost ...

  18. Surface Environmental Surveillance Procedures Manual

    Energy Technology Data Exchange (ETDEWEB)

    RW Hanf; TM Poston


    Environmental surveillance data are used in assessing the impact of current and past site operations on human health and the environment, demonstrating compliance with applicable local, state, and federal environmental regulations, and verifying the adequacy of containment and effluent controls. SESP sampling schedules are reviewed, revised, and published each calendar year in the Hanford Site Environmental Surveillance Master Sampling Schedule. Environmental samples are collected by SESP staff in accordance with the approved sample collection procedures documented in this manual.

  19. Linaclotide: first global approval. (United States)

    McWilliams, Vanessa; Whiteside, Glenn; McKeage, Kate


    Linaclotide is a once-daily, orally administered, first-in-class agonist of guanylate cyclase-C that is minimally absorbed. It is being developed to treat gastrointestinal disorders by Ironwood Pharmaceuticals and its partners, Forest Laboratories (North America), Almirall (Europe) and Astellas Pharma (Asia-Pacific). Linaclotide has received its first global approval in the US for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC), and a marketing submission has been filed in the EU for IBS-C. This article summarizes the milestones in the development of linaclotide leading to this first approval for IBS-C and CIC. This profile has been extracted and modified from the Adis R&D Insight drug pipeline database. Adis R&D Insight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch.

  20. Pitolisant: First Global Approval. (United States)

    Syed, Yahiya Y


    Pitolisant (Wakix™) is an inverse agonist of the histamine H3 receptor that is being developed by Bioproject. Oral pitolisant is approved in the EU for the treatment of narcolepsy with or without cataplexy in adults. Pitolisant has received a Temporary Authorization of Use in France for this indication in case of treatment failure, intolerance or contraindication to currently available treatment. Pitolisant has orphan drug designation in the EU and the USA. In the pivotal HARMONY I trial, pitolisant significantly decreased excessive daytime sleepiness versus placebo in adults with narcolepsy with or without cataplexy (primary endpoint). Pitolisant also significantly decreased cataplexy rate versus placebo in these patients. This article summarizes the milestones in the development of pitolisant leading to this first approval for narcolepsy.

  1. Baricitinib: First Global Approval. (United States)

    Markham, Anthony


    Baricitinib (Olumiant™) is an orally-administered, small-molecule, janus-associated kinase (JAK) inhibitor developed by Eli Lilly and Incyte Corporation for the treatment of rheumatoid arthritis (RA), atopic dermatitis and systemic lupus erythematosus. JAKs transduce intracellular signals from cell surface receptors for various cytokines and growth factors involved in inflammation and immune function, suggesting JAK inhibitors may be of therapeutic benefit in inflammatory conditions. In February 2017, baricitinib was approved in the EU, as monotherapy or in combination with methotrexate, for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs (DMARDs). Regulatory approval to market baricitinib as a treatment for RA has also been sought in the USA and Japan. This article summarizes the milestones in the development of baricitinib leading to this first global approval for the treatment for moderate to severe active RA in adult patients who have responded inadequately to, or are intolerant to one or more DMARDs.

  2. Evolocumab: First Global Approval. (United States)

    Markham, Anthony


    Evolocumab (Repatha™) is a fully human monoclonal antibody developed by Amgen that has been approved as a treatment for hypercholesterolaemia in the EU, and is awaiting approval in the USA and Japan. It specifically binds proprotein convertase subtilisin/kexin type 9 (PCSK9)-a negative regulator of low-density lipoprotein (LDL)-receptors-thereby improving the ability of the liver to bind LDL-cholesterol (LDL-C), leading to reduced LDL-C blood levels. The drug reduces LDL-C levels in patients with hypercholesterolaemia when used as monotherapy or in conjunction with a statin. This article summarizes the milestones in the development of evolocumab leading to this approval for the treatment of adults with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia as an adjunct to diet with or without a statin and/or other lipid lowering therapies, and in adults and adolescents aged ≥12 years with homozygous familial hypercholesterolaemia in combination with other lipid lowering therapies.

  3. 7 CFR 983.52 - Failed lots/rework procedure. (United States)


    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Failed lots/rework procedure. 983.52 Section 983.52..., ARIZONA, AND NEW MEXICO Regulations § 983.52 Failed lots/rework procedure. (a) Substandard pistachios... committee may establish, with the Secretary's approval, appropriate rework procedures. (b) Failed...

  4. 46 CFR 160.151-11 - Approval procedure. (United States)


    ... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS... inflation system; (6) Plans for the outer container; (7) Plans for any lifting shackle or ring, including diameter in cross-section, used for connecting the suspension tackle of a davit-launched...

  5. 34 CFR 668.145 - Test approval procedures. (United States)


    ... test publisher, the Secretary selects experts in the field of educational testing and assessment, who possess appropriate advanced degrees and experience in test development or psychometric research,...

  6. 47 CFR 68.211 - Terminal equipment approval revocation procedures. (United States)


    ... CARRIER SERVICES (CONTINUED) CONNECTION OF TERMINAL EQUIPMENT TO THE TELEPHONE NETWORK Terminal Equipment... to cause harms to the public switched telephone network, as defined in § 68.3; (3) The responsible... authorized for connection to the public switched telephone network for a period of six months from the...

  7. 50 CFR 221.74 - Has OMB approved the information collection provisions of this subpart? (United States)


    ... PRESCRIPTIONS IN FERC HYDROPOWER LICENSES Alternatives Process § 221.74 Has OMB approved the information collection provisions of this subpart? Yes. This rule contains provisions that would collect information from... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Has OMB approved the...

  8. 13 CFR 107.503 - Licensee's adoption of an approved valuation policy. (United States)


    ... independent public accountant's report on your audited annual financial statements (SBA Form 468) must include a statement that your valuations were prepared in accordance with your approved valuation policy... approval of an alternative valuation policy. (c) Responsibility for valuations. Your board of directors...

  9. 21 CFR 900.18 - Alternative requirements for § 900.12 quality standards. (United States)


    ... SERVICES (CONTINUED) MAMMOGRAPHY QUALITY STANDARDS ACT MAMMOGRAPHY Quality Standards and Certification § 900.18 Alternative requirements for § 900.12 quality standards. (a) Criteria for approval of... may approve an alternative to a quality standard under § 900.12, when the agency determines that:...

  10. 75 FR 10013 - Agency Information Collection Activities: Request for Comments; Renewed Approval of Information... (United States)


    ... in a right-of-way procedural (operations) manual the organization, policies and procedures of the...-date right-of-way procedural manual is set out in 23 CFR 710.201(c). The regulation allows States... Approval of Information Collection; State Right-of-Way Operations Manuals, OMB Control Number:...

  11. Current therapeutic procedures in Dravet syndrome. (United States)

    Chiron, Catherine


    Dravet syndrome is a highly pharmaco-resistant form of epilepsy. Valproate and benzodiazepines are the first-line treatment but are usually insufficient therapeutic options. Lamotrigine, carbamazepine and high doses of intravenous phenobarbital can aggravate seizures and should be avoided. Topiramate, levetiracetam, bromide and ketogenic diet also provide substantial efficacy as adjunctive therapy and procedures. Stiripentol is the only new drug to demonstrate efficacy when combined with valproate and clobazam, as shown in two independent double-blind controlled trials dedicated to Dravet children. In order to avoid side effects (mainly loss of appetite and loss of weight) resulting from the inhibition of cytochromes P450 by stiripentol, the prescribed doses of valproate and clobazam should be reduced. Stiripentol has a proper antiepileptic effect and enhances GABAergic neurotransmission by acting on the alpha-3 subunit of GABA(A) receptors. Stiripentol was approved as an orphan drug in Europe in 2007 for adjunctive therapy in Dravet syndrome. More than 500 Dravet patients have currently been satisfactorily treated and recent experiments in Japan have confirmed stiripentol's benefit. In practice, valproate should be initiated at the first onset of complicated febrile seizure in Dravet patients. Relapses justify the addition of clobazam and stiripentol when available. Topiramate and a ketogenic diet are alternatives in pharmaco-resistant cases.

  12. 5 CFR 2471.1 - Request for Panel consideration; request for Panel approval of binding arbitration. (United States)


    ... for Panel approval of binding arbitration. 2471.1 Section 2471.1 Administrative Personnel FEDERAL... consideration; request for Panel approval of binding arbitration. If voluntary arrangements, including the... procedure, which they have agreed to adopt, for binding arbitration of the negotiation impasse by filing...

  13. 40 CFR 131.21 - EPA review and approval of water quality standards. (United States)


    ... (CONTINUED) WATER PROGRAMS WATER QUALITY STANDARDS Procedures for Review and Revision of Water Quality Standards § 131.21 EPA review and approval of water quality standards. (a) After the State submits its... analysis. (b) The Regional Administrator's approval or disapproval of a State water quality standard...

  14. 7 CFR 1724.54 - Requirements for RUS approval of plans and specifications. (United States)


    ... specifications for transmission construction projects which are not based on RUS approved line design data or do... building design meets the Uniform Federal Accessibility Standards (See § 1724.51(e)(1)(i)). (g... DESIGN POLICIES AND PROCEDURES Electric System Design § 1724.54 Requirements for RUS approval of...

  15. Approval and Disapproval of Textbooks in the Late Ottoman Empire (United States)

    Açikgöz, Betül


    During the rapidly changing political atmosphere of the 1910s, the practice of sanctioning scholastic knowledge began to be implemented in the yearly selection of textbooks due to political contingencies. The study shows the procedures of approval and disapproval practised by the Grand Council of Education and the Copyright and Translation Office…

  16. 29 CFR 1952.104 - Final approval determination. (United States)


    ... dam construction projects; and private sector maritime employment on or adjacent to navigable waters... Final approval determination. (a) In accordance with Section 18(e) of the Act and procedures in 29 CFR... exception of temporary labor camps in agriculture, general industry, construction and logging) is at...

  17. 14 CFR 21.500 - Approval of engines and propellers. (United States)


    ... AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Approval of Engines, Propellers, Materials, Parts.... type certificate for an aircraft engine or propeller manufactured in a foreign country with which the... with each such aircraft engine or propeller imported into this country, a certificate of...

  18. 78 FR 66826 - Prior Label Approval System: Generic Label Approval (United States)


    ... submitted for evaluation and approval before use under the final rule are: (1) Labels for chicken produced..., such as ``no antibiotics administered'' or ``vegetarian fed''; (4) instructional or...

  19. 75 FR 4742 - Approval and Promulgation of Implementation Plans; State of California; Legal Authority (United States)


    ..., Penal, Civil Procedure, Government, and Vehicle codes, as well as citations to (then) recently approved...), certain Penal Code sections, Senate Bill 678 (related to authority of attorney general to protect...

  20. 14 CFR 17.31 - Use of alternative dispute resolution. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Use of alternative dispute resolution. 17... PROCEDURAL RULES PROCEDURES FOR PROTESTS AND CONTRACTS DISPUTES Alternative Dispute Resolution § 17.31 Use of alternative dispute resolution. (a) The Office of Dispute Resolution for Acquisition shall encourage...

  1. Dental Procedures. (United States)

    Ramponi, Denise R


    Dental problems are a common complaint in emergency departments in the United States. There are a wide variety of dental issues addressed in emergency department visits such as dental caries, loose teeth, dental trauma, gingival infections, and dry socket syndrome. Review of the most common dental blocks and dental procedures will allow the practitioner the opportunity to make the patient more comfortable and reduce the amount of analgesia the patient will need upon discharge. Familiarity with the dental equipment, tooth, and mouth anatomy will help prepare the practitioner for to perform these dental procedures.

  2. Obinutuzumab: first global approval. (United States)

    Cameron, Fiona; McCormack, Paul L


    Obinutuzumab (Gazyva™) is an intravenously administered, humanized and glycoengineered, type II anti-CD20 monoclonal antibody for the treatment of B-cell malignancies. It is approved in the US for use in combination with chlorambucil for the first-line treatment of chronic lymphocytic leukaemia (CLL), and has been filed for approval in the EU in this indication. The antibody is based on GlycArt Biotechnology's (later Roche Glycart AG) proprietary GlycoMAb® technology, which uses glycoengineered antibodies that specifically increase antibody-dependent cellular cytotoxicity and thereby increase immune-mediated target cell death. Obinutuzumab is a type II anti-CD20 antibody that induces enhanced direct cell death. The monoclonal antibody is in worldwide phase III development with Roche and its subsidiaries, Genentech and Chugai Pharmaceutical, as well as Biogen Idec, for diffuse large B-cell lymphoma and non-Hodgkin's lymphoma generally, and is also in phase III development in countries outside of the US and EU for CLL.

  3. Safinamide: first global approval. (United States)

    Deeks, Emma D


    Safinamide (Xadago(®)) is an oral α-aminoamide derivative developed by Newron for the treatment of Parkinson's disease (PD). The drug has both dopaminergic properties (highly selective and reversible inhibition of monoamine oxidase-B) and non-dopaminergic properties (selective sodium channel blockade and calcium channel modulation, with consequent inhibition of excessive glutamate release). Safinamide is approved in the EU, Iceland, Lichtenstein and Norway, as an add-on therapy to stable-dose levodopa, alone or in combination with other PD therapies in mid- to late-stage fluctuating PD patients; regulatory submissions have also been filed in the USA and Switzerland for its use in this indication. Additional submissions have been made in the USA, Iceland, Lichtenstein, Norway and Switzerland for early-stage PD. Safinamide has also undergone phase II investigation in PD patients with drug-induced dyskinesia (France, Germany, Austria, Canada and South Africa) or cognitive impairment (USA and Spain). This article summarizes the milestones in the development of safinamide leading to its first approval for PD.

  4. Drugs Approved for Cervical Cancer (United States)

    ... Human Papillomavirus (HPV) Nonavalent Vaccine Recombinant Human Papillomavirus (HPV) Quadrivalent Vaccine Drugs Approved to Treat Cervical Cancer Avastin (Bevacizumab) Bevacizumab Blenoxane (Bleomycin) Bleomycin Hycamtin (Topotecan ...

  5. Yttrium-90 Resin Microsphere Radioembolization Using an Antireflux Catheter: An Alternative to Traditional Coil Embolization for Nontarget Protection

    Energy Technology Data Exchange (ETDEWEB)

    Morshedi, Maud M., E-mail:; Bauman, Michael, E-mail:; Rose, Steven C., E-mail:; Kikolski, Steven G., E-mail: [University of California San Diego Health Sciences, Radiology Department, University of California San Diego Medical Center (United States)


    PurposeSerious complications can result from nontarget embolization during yttrium-90 (Y-90) transarterial radioembolization. Hepatoenteric artery coil embolization has been traditionally performed to prevent nontarget radioembolization. The U.S. Food and Drug Administration–approved Surefire Infusion System (SIS) catheter, designed to prevent reflux, is an alternative to coils. The hypothesis that quantifiable SIS procedural parameters are comparable to coil embolization was tested.MethodsFourteen patients aged 36–79 years with colorectal, neuroendocrine, hepatocellular, and other predominantly bilobar hepatic tumors who underwent resin microsphere Y-90 radioembolization using only the SIS catheter (n = 7) versus only detachable coils (n = 7) for nontarget protection were reviewed retrospectively. Procedure time, fluoroscopy time, contrast dose, radiation dose, and cost were evaluated.ResultsMultivariate analysis identified significant cohort differences in the procedural parameters evaluated (F(10, 3) = 10.39, p = 0.04). Between-group comparisons of the pretreatment planning procedure in the SIS catheter group compared to the coil embolization group demonstrated a significant reduction in procedure time (102.6 vs. 192.1 min, respectively, p = 0.0004), fluoroscopy time (14.3 vs. 49.7 min, respectively, p = 0.0016), and contrast material dose (mean dose of 174.3 vs. 265.0 mL, respectively, p = 0.0098). Procedural parameters were not significantly different between the two groups during subsequent dose delivery procedures. Overall cost of combined first-time radioembolization procedures was significantly less in the SIS group ($4252) compared to retrievable coil embolization ($11,123; p = 0.001).ConclusionThe SIS catheter results in a reduction in procedure time, fluoroscopy time, and contrast material dose and may be an attractive cost-effective alternative to detachable coil embolization for prevention of nontarget radioembolization.

  6. Alternative Energies

    Energy Technology Data Exchange (ETDEWEB)

    Planting, A.; De saint Jacob, Y.; Verwijs, H.; Belin, H.; Preesman, L.


    In two articles, one interview and one column attention is paid to alternative energies. The article 'A new light on saving energy' discusses the option to save energy by modernising lighting systems in urban areas. The column 'View from Paris' focuses on investment decisions in France with regard to renewable energy and energy savings. The article 'Europe turns a blind eye to big battery' discusses developments in batteries to store energy. The interview concerns fuel cell expert and formerly President of UTC Power Jan van Dokkum. The last article gives a brief overview of the European Energy Research Alliance (EERA) and the challenges this alliance will have to face with regard to climate change and energy security.

  7. 7 CFR 58.141 - Alternate quality control program. (United States)


    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Alternate quality control program. 58.141 Section 58... Service 1 Quality Specifications for Raw Milk § 58.141 Alternate quality control program. When a plant has in operation an acceptable quality program, at the producer level, which is approved by...

  8. 42 CFR 447.256 - Procedures for CMS action on assurances and State plan amendments. (United States)


    ... 42 Public Health 4 2010-10-01 2010-10-01 false Procedures for CMS action on assurances and State... for Inpatient Hospital and Long-Term Care Facility Services Payment Rates § 447.256 Procedures for CMS action on assurances and State plan amendments. (a) Criteria for approval. (1) CMS approval action...

  9. Approval of raxibacumab for the treatment of inhalation anthrax under the US Food and Drug Administration Animal rule

    Directory of Open Access Journals (Sweden)

    Chia-Wei eTsai


    Full Text Available On December 14, 2012, the FDA approved raxibacumab, the first product developed under Project BioShield to achieve this milestone, and the first biologic product to be approved through the FDA animal efficacy rule (or Animal Rule. Raxibacumab is approved for the treatment of adult and pediatric patients with inhalational anthrax due to Bacillus anthracis in combination with appropriate antibiotic drugs and for prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate. The approval of Raxibacumab illustrates many of the challenges that product developers may encounter when pursuing approval under the Animal Rule and highlights a number of important regulatory and policy issues.

  10. Alternative Assessment

    Directory of Open Access Journals (Sweden)

    Dulce Porto Rodrigues


    Full Text Available O ensino/aprendizagem tem mudado nas últimas três décadas e também a avaliação que não deve ser vista apenas como uma forma de testar os alunos e promovê-los, mas ajudá-los a se envolver no processo de aprendizagem, e que forneça ao professor informações para o planejamento de instrução e práticas pedagógicas. É um diagnóstico dos pontos fortes e fracos do aluno que direciona a sala de aula para a avaliação através de atividades reunidas em portfólio, incluindo todas as ações do processo ensino/ aprendizagem, visando atender às necessidades dos domínios cognitivos, afetivos e psicomotores do aluno, definir objetivos, planejamento e instrução, o envolvimento do aprendiz em sua aprendizagem e a avaliação, desconstruindo, construindo e reconstruindo o seu conhecimento.The teaching/learning has changed over the past three decades and assessment musn´t be seen as just a means of testing learners´ achievement and promotion. This type of evaluation helps students get more involved in their learning and provides teachers with useful information as the basis for instructional plans and pedagogical practices. It is a way of diagnosing the students´ strengths and weaknesses so that class procedures are directed to include activities in which students measurable outcomes are collected in a portfolio that include all types of learning/assessment procedures aiming to match the students´ cognitive, affective and psychomotor domains, to define objectives, planning, instruction and active participation in the process, deconstructing, constructing and reconstructing knowledge.

  11. 12 CFR 611.501 - Procedures. (United States)


    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Procedures. 611.501 Section 611.501 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Transfer of Authorities § 611.501... information shall be submitted to the Farm Credit Administration for review and approval: (1) Any...

  12. Adapting drug approval pathways for bacteriophage-based therapeutics

    Directory of Open Access Journals (Sweden)

    Callum Cooper


    Full Text Available The global rise of multi-drug resistant bacteria has resulted in the notion that an antibiotic apocalypse is fast approaching. This has led to a number of well publicized calls for global funding initiatives to develop new antibacterial agents. The long clinical history of phage therapy in Eastern Europe, combined with more recent in vitro and in vivo success, demonstrates the potential for whole phage or phage based antibacterial agents. To date, no whole phage or phage derived products are approved for human therapeutic use in the EU or USA. There are at least three reasons for this: (i phages possess different biological, physical and pharmacological properties compared to conventional antibiotics. Phages need to replicate in order to achieve a viable antibacterial effect, resulting in complex pharmacodynamics / pharmacokinetics. (ii The specificity of individual phages requires multiple phages to treat single species infections, often as part of complex cocktails. (iii The current approval process for antibacterial agents has evolved with the development of chemically based drugs at its core, and is not suitable for phages. Due to similarities with conventional antibiotics, phage derived products such as endolysins are suitable for approval under current processes as biological therapeutic proteins. These criteria render the approval of phages for clinical use theoretically possible but not economically viable. In this review, pitfalls of the current approval process will be discussed for whole phage and phage derived products, in addition to the utilization of alternative approval pathways including adaptive licensing and Right to try legislation.

  13. FDA-Approved HIV Medicines (United States)

    HIV Treatment FDA-Approved HIV Medicines (Last updated 2/27/2017; last reviewed 2/27/2017) Treatment with HIV medicines is ... approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in the ...

  14. The dilemma of approving antidotes. (United States)

    Steffen, Christian


    Clinical trials with antidotes are difficult to perform for a variety of practical, ethical, and financial reasons. As acute poisoning is a rare event, the commercial interest in basic and clinical research is low. Poisoned patients are usually not available for normal clinical trial procedures and, if they are, they cannot give informed consent. This situation results in a dilemma: antidotes are essential drugs. A resolution of the Council of Europe requests to guarantee the optimal availability of antidotes and the improvement of their use. As comprehensive data on the efficacy of antidotes are often missing, a marketing authorisation under exceptional circumstances according to Article 14(8) of Regulation (EC) No. 276/2004, will often be the only way to get an approval, as: (1) the indications for which the product in question is intended are encountered so rarely that the applicant cannot reasonably be expected to provide comprehensive evidence ("orphan drug"), (2) in the present state of scientific knowledge, comprehensive information cannot be provided, or (3) it would be contrary to generally accepted principles of medical ethics to collect such data. Typically, data on antidotes are obtained from a patchwork of studies with animals, human tissue and a few observations from human poisoning corroborated with data from clinical observations and biochemistry. Generalisations from chemical and mechanistic similarities between groups of poisons are usual, but often lack scientific evidence. Current standards of good clinical practice can rarely be observed. Therefore, public funding and other financial support are necessary incentives to initiate trials in this important area.

  15. 42 CFR 84.50 - Types of respirators to be approved; scope of approval. (United States)


    ... 42 Public Health 1 2010-10-01 2010-10-01 false Types of respirators to be approved; scope of... Classification of Approved Respirators; Scope of Approval; Atmospheric Hazards; Service Time § 84.50 Types of respirators to be approved; scope of approval. Approvals shall be issued for the types of respirators...

  16. Intravenous infusion of ketamine-propofol can be an alternative to intravenous infusion of fentanyl-propofol for deep sedation and analgesia in paediatric patients undergoing emergency short surgical procedures

    Directory of Open Access Journals (Sweden)

    Samit Kumar Khutia


    Full Text Available Background: Paediatric patients often present with different painful conditions that require immediate surgical interventions. Despite a plethora of articles on the ketamine-propofol combination, comprehensive evidence regarding the suitable sedoanalgesia regime is lacking due to heterogeneity in study designs. Methods: This prospective, randomized, double-blind, active-controlled trial was conducted in 100 children, of age 3-14 years, American Society of Anesthesiologist physical status IE-IIE, posted for emergency short surgical procedures. Patients were randomly allocated to receive either 2 mL of normal saline (pre-induction plus calculated volume of drug from the 11 mL of ketamine-propofol solution for induction (group PK, n=50 or fentanyl 1.5 μg/kg diluted to 2 mL with normal saline (pre-induction plus calculated volume of drug from the 11 mL of propofol solution for induction (group PF, n=50. In both the groups, the initial bolus propofol 1 mg/kg i.v. (assuming the syringes contained only propofol, for simplicity was followed by adjusted infusion to achieve a Ramsay Sedation Scale score of six. Mean arterial pressure (MAP was the primary outcome measurement. Results: Data from 48 patients in group PK and 44 patients in group PF were available for analysis. Hypotension was found in seven patients (14.6% in group PK compared with 17 (38.6% patients in group PF (P=0.009. Intraoperative MAP was significantly lower in group PF than group PK when compared with baseline. Conclusion: The combination of low-dose ketamine and propofol is more effective and a safer sedoanalgesia regimen than the propofol-fentanyl combination in paediatric emergency short surgical procedures in terms of haemodynamic stability and lesser incidence of apnoea.

  17. Drugs Approved for Stomach (Gastric) Cancer (United States)

    ... about Your Treatment Research Drugs Approved for Stomach (Gastric) Cancer This page lists cancer drugs approved by the ... are not listed here. Drugs Approved for Stomach (Gastric) Cancer Cyramza (Ramucirumab) Docetaxel Doxorubicin Hydrochloride 5-FU (Fluorouracil ...

  18. Punishment and Alternative Strategies for Decreasing a Behavior. (United States)

    Vought, James J.


    Provides an overview on the subject of punishment and alternative procedures to decelerate a behavior. Describes differential reinforcement, extinction, satiation, corrective feedback, using peers as models and rearranging the environment as positive and nonaversive procedures for decreasing a behavior. (LLL)

  19. 28 CFR 42.734 - Alternative funding. (United States)


    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Alternative funding. 42.734 Section 42.734 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY...; Implementation of the Age Discrimination Act of 1975 Compliance Procedures § 42.734 Alternative funding....

  20. Biosimilars approval process. (United States)

    Zuñiga, Leyre; Calvo, Begoña


    For similar biological medicinal products, the so-called biosimilars, clinical trials are required rather than just the bioequivalence studies required to support the registration of a generic small molecule drug product. The EU Directive 2001/83/EC, as amended, stated that where a biological medicinal product which is similar to a reference biological product, does not meet the conditions in the definition of generic medicinal products the results of appropriate pre-clinical tests or clinical trials relating to these conditions must be provided. The challenge is to determine the exact nature of the non-clinical and clinical programme required to gain regulatory approval. The applicant is encouraged to provide a detailed description of the strategy used to demonstrate the biosimilar and the reference product have similar profiles in terms of quality, safety and efficacy. The extent to which comparability can be proven will have quite an impact on how many non-clinical and clinical studies the biosimilar applicant will be required to conduct. The dossier submitted by the applicant to the EMEA should cover all aspects of the comparability assessment and must include data on possible unwanted immune reactions to the therapeutic protein. Post-marketing pharmacovigilance plans are also expected to be included in the biosimilar dossier.

  1. Looking for an Alternative. (United States)

    Kennedy, Jack


    Argues that high school newspapers might do well to create stronger ties with alternative weeklies. Discusses issues of niche marketing, alternative content, and alternative presentation. Notes that high school papers could learn a lot from alternative newspapers. (SR)

  2. On the isolation of elemental carbon for micro-molar 14C accelerator mass spectrometry; evaluation of alternative isolation procedures, and accuracy assurance using a hybrid isotopic particulate carbon reference material

    Directory of Open Access Journals (Sweden)

    L. A. Currie


    Full Text Available The primary objective of the research reported here has been the development of an hybrid reference material (RM to serve as a test of accuracy for elemental carbon (EC isotopic (14C speciation measurements. Such measurements are critically important for the quantitative apportionment of fossil and biomass sources of ''soot'' (EC, the tracer of fire that has profound effects on health, atmospheric visibility, and climate. Previous studies of 14C-EC measurement quality, carried out with NIST SRM 1649a (Urban Dust, showed a range of results, but since the ''truth'' was not known for this natural matrix RM, one had to rely on isotopic-chemical consistency evidence (14C in PAH, EC of measurement validity (Currie et al., 2002. Components of the new Hybrid RM (DiesApple, however, have known 14C and EC composition, and they are nearly orthogonal (isotopically and chemically. NIST SRM 2975 (Forklift Diesel Soot has little or no 14C, and its major compositional component is EC. SRM 1515 (Apple Leaves has the 14C content of biomass-C, and it has little or no EC. Thus, the hybrid RM can serve as an absolute isotopic test for the absence of EC-mimicking pyrolysis-C from SRM 1515 in the EC isolate of the hybrid RM, together with testing for conservation of its dominant soot fraction through the isolation procedure.

  3. Terapia celular associada à revascularização transmiocárdica laser como proposta no tratamento da angina refratária Cell therapy plus transmyocardial laser revascularization: a proposed alternative procedure for refractory angina

    Directory of Open Access Journals (Sweden)

    Luís Alberto Oliveira Dallan


    Full Text Available OBJETIVO: É descrita uma proposição cirúrgica para o tratamento de pacientes com doença arterial coronária (DAC terminal, não mais passíveis de revascularização miocárdica convencional. Constitui-se na revascularização transmiocárdica com raios laser (RTML, associada ao emprego de células progenitoras hematopoiéticas autólogas (CPH. MÉTODOS: Nove pacientes (oito homens, 65±5 anos, com as características supracitadas foram submetidos ao procedimento combinado. Além da avaliação clínica, o protocolo incluiu o estudo da perfusão miocárdica através da ressonância cardíaca (RMC sob estresse farmacológico, antes e seis meses após a intervenção cirúrgica. Procedeuse à RMTL através de minitoracotomia esquerda e utilização de laser de CO2, com média de 11±3 tiros por paciente. As CPH foram obtidas por punção medular, seguindo-se sua injeção direta (1,9±0,3x10(8 células/paciente em múltiplas áreas do miocárdio isquêmico. RESULTADOS: Não ocorreram óbitos ou complicações imediatas decorrentes dos procedimentos. Um paciente faleceu no segundo ano de pós-operatório, de causa não cardíaca (choque séptico. O seguimento clínico pós-operatório desses pacientes revelou redução significativa da classe funcional de angina de 3,7±0,2 para 1,3±0,2 (pOBJECTIVE: We tested the hypothesis that TMLR combined with intramyocardial injection of BMC is safe, and may help increase the functional capacity of patient with refractory angina. METHODS: Nine patients (eight men, 65±5 years old, with refractory angina for multivessel disease and previous myocardial revascularization procedures (CABG/PCI, not candidates for another procedure due to the extension of the disease were enrolled. TMLR (11±3 laser drills was performed via a limited thoracotomy using a CO2 Heart Laser System. BMC were obtained immediately prior to surgery, and the lymphomonocytic fraction separated by density gradient centrifugation. During

  4. 14 CFR 151.29 - Procedures: Offer, amendment, and acceptance. (United States)


    ... § 151.29 Procedures: Offer, amendment, and acceptance. (a) Upon approving a project, the Administrator... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Procedures: Offer, amendment, and acceptance. 151.29 Section 151.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT...

  5. Drugs Approved for Liver Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for liver cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  6. Drugs Approved for Vulvar Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for vulvar cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  7. Drugs Approved for Esophageal Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for esophageal cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  8. Drugs Approved for Vaginal Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) to prevent vaginal cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  9. Drugs Approved for Endometrial Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for endometrial cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  10. Drugs Approved for Penile Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for penile cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  11. Is It Really FDA Approved? (United States)

    ... does not approve cosmetics. Examples of cosmetics are perfumes, makeup, moisturizers, shampoos, hair dyes, face and body ... and provide the agency with a notification before marketing a new formula. FDA conducts yearly inspections of ...

  12. Electronic Voucher Approval - Financial Management (United States)

    US Agency for International Development — This process provides a workflow and eSignature capability which allows the CFO to router vouchers for review and electronic signature approval to COTRs in AIDW. It...

  13. Drugs Approved for Bladder Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bladder cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  14. Drugs Approved for Skin Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for skin cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  15. Drugs Approved for Breast Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for breast cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  16. Drugs Approved for Kaposi Sarcoma (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Kaposi sarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  17. Drugs Approved for Pancreatic Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for pancreatic cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  18. Drugs Approved for Bone Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bone cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  19. Elosulfase alfa: first global approval. (United States)

    Sanford, Mark; Lo, Jin Han


    Elosulfase alfa (Vimizim™) is a recombinant form of N-acetylgalactosamine-6-sulfatase (GALNS) that was developed by BioMarin Pharmaceutical Inc. as an enzyme replacement therapy for patients with mucopolysaccharidosis type IVA (MPS IVA), also known as Morquio A syndrome. Patients with MPS IVA have a GALNS deficiency, which results in serious musculoskeletal, cardiorespiratory and other system disturbances. Elosulfase alfa was approved by the US FDA on 14 February 2014 for the treatment of MPS IVA. The European Medicines Agency Committee for Medicinal Products for Human Use (CHMP) has recently recommended that elosulfase alfa be approved for use in the EU in the same indication. Within the last year, the manufacturer has also filed applications for approval for the use of elosulfase alfa in MPS IVA in Brazil, Australia, Canada and Mexico. This article summarizes the milestones in the development of elosulfase alfa leading to its first global approval in MPS IVA.

  20. Drugs Approved for Prostate Cancer (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for prostate cancer. The list includes generic ...

  1. Trulance Approved for Chronic Constipation (United States)

    ... news/fullstory_163171.html Trulance Approved for Chronic Constipation Drug designed to stimulate upper gastrointestinal tract To ... U.S. Food and Drug Administration to treat persistent constipation of unknown (idiopathic) cause in adults. Some 42 ...

  2. Antiguo procedimiento como nueva técnica alternativa en el cálculo optimizado de engranajes. // Old procedure as a new alternative in the optimized calculation of gears.

    Directory of Open Access Journals (Sweden)

    G. González Rey


    Full Text Available A pesar de que la optimización y el diseño racional de los engranajes han sido temas de muchas investigaciones, aún siguensiendo del interés de muchos especialistas y estudiosos de los engranajes. Las razones fundamentales para este hecho estáncondicionadas en primer lugar a que el diseño de un engranaje es en extremo complejo debido al número de variables,limitaciones y relaciones que involucra, y por otro lado existe la particularidad de que para cada caso de optimización lafunción objetivo, las restricciones y las variables independientes son generalmente diferentes. Desde hace más de dosdécadas, el método de búsqueda exhaustiva, como técnica de localización de los extremos de una función objetivo, es sinlugar a dudas uno de los procedimientos de optimización más empleado en el cálculo racional de los engranajes. En eltrabajo se exponen las bases del método de búsqueda exhaustiva y es mostrada su aplicabilidad en la síntesis geométricaracional de un engranaje cónico de dientes rectos.Palabras claves: Engranaje cónico, optimización, diseño, método de búsqueda exhaustiva.___________________________________________________________________________Abstract.:The optimization and rational design of gears have been topics of many investigations and continue being of the interest ofmany specialists and studious of this field. The fundamental reasons are conditioned in first place to the fact that the geardesign is very complex due to the number of variables, limitations and relations that involves, and on the other hand there isthe particularity that for each case of optimization the objective function, the restrictions and the independent variables aregenerally different. Since two decades, the exhaustive search method is one of the optimization procedures more used in therational calculation of gears. In this paper are exposed the bases of the exhaustive search method and shown itsapplicability in the rational geometric

  3. Avaliação assistida e comunicação alternativa: procedimentos para a educação inclusiva Dynamic assessment and augmentative and alternative communication: procedures for inclusive education

    Directory of Open Access Journals (Sweden)

    Kely Maria Pereira de Paula


    a promising field where its innovative features differ from traditional assessment by favoring the population that presents challenges in the learning processes or who present socially disadvantaged conditions. Children who need alternative resources for expressive language constitute a significant group that can be benefited from assessment tailored to their needs. In this study, seven children with special needs (communication problems took part in a dynamic assessment situation using Tzuriel and Klein's Children's Analogical Thinking Modifiability Test (CATM, in order to complete the psychometric assessment carried out by Raven, Columbia and TVIP tests. The latter was a computerized version, applied before and after intervention with an Augmentative and Alternative Communication (AAC system. Besides the thought processes, other not specifically cognitive aspects of great importance were considered: the child's reaction to the assessment situation and the kind of task put before, personal and situational variables such as motivation and fatigue, as well as accessibility to the mediation strategies. Such variables were systematized in cognitive, behavioral and affective-motivational categories in the teaching and intervention contexts compounding a mosaic of indicators about the characteristics of children with communicative deficits at different stages of the study. Even though the assessment conditions - traditional and dynamic - were tiring for the children, we were able to identify the operations and cognitive dysfunctions both in the traditional tests and in the dynamic testing, as well as in the intervention. Furthermore, affective-motivational and behavioral factors were shown to affect performance, composing an intra-group learning profile for problem solving. Thus, the study demonstrated that dynamic assessment can be an important tool for psychological diagnosis, complementing traditional psychometric approach, for children with communication problems.

  4. Integrating Language Skills through a Dictogloss Procedure (United States)

    Stewart, Benjamin Lee; Rodríguez Silva, Luis Humberto; Torres González, Juan Antonio


    In this article, the authors offer an alternative to traditional methods of teaching English that often included translating structures from the target language to the mother tongue. Although this method seems antiquated, it is still commonly practiced, as original dictogloss procedures were intended to provide an alternative to traditional…

  5. 75 FR 52591 - Seventh Meeting: RTCA Special Committee 221: Aircraft Secondary Barriers and Alternative Flight... (United States)


    ... and Alternative Flight Deck Security Procedures AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 221 meeting: Aircraft Secondary Barriers and Alternative Flight... RTCA Special Committee 221: Aircraft Secondary Barriers and Alternative Flight Deck Security...

  6. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan. (United States)


    ... Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions... fleets, a State may follow a Light Duty Alternative Fueled Vehicle Plan that has been approved by...

  7. An Evaluation of the Sheridan County School District Alternative School Schedule, 1982-83. (United States)

    Nelson, Steven R.

    During the 1982-83 school year, the Sheridan County School District implemented a 4-day school week alternative schedule. The alternative schedule was approved by the Wyoming State Board of Education on two conditions. First, the State Attorney General must affirm the State Board's right to permit alternative scheduling. Second, an outside…

  8. 7 CFR 905.120 - Nomination procedure. (United States)


    ... nominations for members and alternate members of the Citrus Administrative Committee. The manner of nominating... 7 Agriculture 8 2010-01-01 2010-01-01 false Nomination procedure. 905.120 Section 905.120..., AND TANGELOS GROWN IN FLORIDA Rules and Regulations § 905.120 Nomination procedure. Meetings shall...

  9. Harmful aquatic organisms in ballast water: application for basic approval of the VARUNA ballast water treatment system

    NARCIS (Netherlands)

    Jak, R.G.; Jongbloed, R.H.; Sneekes, A.C.; Kaag, N.H.B.M.


    This document contains the non-confidential information related to the application for Basic Approval of the VARUNA Ballast Water Treatment System submitted in accordance with the Procedure for approval of ballast water management systems that make use of Active Substances (G9) adopted by resolution

  10. Alternatives to animal experimentation in basic research. (United States)

    Gruber, Franz P; Hartung, Thomas


    In contrast to animal testing required by law to guarantee minimum safety standards for the licensing of drugs and chemicals, there are no regulations in basic research forcing scientists to perform animal tests. By (usually) free choice, questions are posed and hypotheses are examined which, in many cases, can only be answered by means of animal tests. Just as easily, different questions could be asked or different hypotheses could be examined which do not require animal tests. The only criterion for the choice of a topic is its relevance which cannot necessarily be judged in the short-term. Thus, it is up to the individual scientist to judge what is worth studying and therefore worth animal consumption. The educated mind will consider ethical aspects of this choice. However, on the other hand, this decision is largely influenced by questions of efficacy or (in a negative sense) by the obstacles posed to an animal consuming approach. Here, peer review and general attitude will strongly influence the methodology chosen. Availability and awareness of adequate in vitro techniques represent the prerequisites for the use of alternative methods. The least one can do in basic research is to avoid tests which cause severe suffering to animals, as is required in Switzerland and other European countries by binding ethical principles and guidelines. The increasing standard of approval and control procedures has improved the situation over the years. There are many examples of successful alternative methods in basic research. But, the application of such methods is in most cases limited to the laboratories in which they were developed, calling for technology transfer. Exceptions are procedures that are used worldwide, like the production of monoclonal antibodies, which instead of using the ascites mouse can also be performed in vitro with some good will. In these cases, commercialisation of the techniques has aided their spread within the scientific community. Sadly, many

  11. Alternative medicine - pain relief (United States)

    Alternative medicine refers to treatments that are used instead of conventional (standard) ones. If you use an alternative ... with conventional medicine or therapy, it is considered complementary therapy. There are many forms of alternative medicine. Acupuncture ...

  12. 77 FR 8865 - Public Water System Supervision Program Approval for the State of Illinois; Tentative Approval (United States)


    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Public Water System Supervision Program Approval for the State of Illinois; Tentative Approval... State of Illinois submitted a primacy application for its approved Public Water System...

  13. 47 CFR 64.1310 - Payphone compensation procedures. (United States)


    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Payphone compensation procedures. 64.1310... compensation procedures. (a) Unless the payphone service provider consents to an alternative compensation... not unreasonably withhold its consent to an alternative compensation arrangement. (1) Each...

  14. Anatomy of Alternating Quantifier Satisfiability (Work in progress)

    DEFF Research Database (Denmark)

    Dung, Phan Anh; Bjørner, Nikolaj; Monniaux, David

    We report on work in progress to generalize an algorithm recently introduced in [10] for checking satisfiability of formulas with quantifier alternation. The algorithm uses two auxiliary procedures: a procedure for producing a candidate formula for quantifier elimination and a procedure for elimi...

  15. Drugs Approved for Hodgkin Lymphoma (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  16. Drugs Approved for Multiple Myeloma (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for multiple myeloma and other plasma cell neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  17. Drugs Approved for Myeloproliferative Neoplasms (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for myeloproliferative neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  18. Alkylbenzene Project in Xinjiang Approved

    Institute of Scientific and Technical Information of China (English)

    Zhou Weiyong


    @@ The feasibility study on alkylbenzene project in Dushanzi, Xinjiang Uygur Autonomous Region, submitted jointly by the government of Xinjiang UygurAutonomous Region and China National Petroleum Corporation (CNPC), has been approved by State Council recently,after pass appraisa l by China International Engineering Consulting Corporation entrusted by State Planning Committee.

  19. An alternative procedure for ESR identification of irradiated chicken drumsticks

    Energy Technology Data Exchange (ETDEWEB)

    Bordi, F. (Rome-2 Univ. (Italy). Dip. di Medicina Interna); Fattibene, P.; Onori, S.; Pantaloni, M. (Istituto Superiore di Sanita, Rome (Italy) Istituto Nazionale di Fisica Nucleare, Rome (Italy))

    The ESR spectroscopy is, at present, the most established technique for quantitative analysis of irradiated chicken bone using the additive dose method. In this paper we tried a different approach to the problem analyzing the ESR behavior of a batch of chicken bone samples coming randomly from the market. Using a suitable and standardized sample preparation technique and sample positioning in the microwave cavity, we obtained a coefficient of variation of about 30% for the batch response. The calibration curve, obtained using the batch behavior up to 10 kGy, was used for a quantitative test on unknown samples. (author).

  20. 5 CFR 2634.905 - Use of alternative procedures. (United States)


    ... FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Confidential Financial Disclosure... requiring the auditor to file a confidential financial disclosure report. (b) An agency may use the OGE... financial institutions. Prior to undertaking each enforcement review, the auditor reviews the file...

  1. 10 CFR 435.305 - Alternative compliance procedure. (United States)


    ... accordance with the following table for a house with 1540 square feet of floor area, adjusted by 0.35 Btu/ft 2/hr to account for changes in lighting as the floor area varies from 1540 square feet— Table 1... (obtainable from National Climatic Data Center, 1983 Test Reference Year, Tape Reference Manual,...

  2. Ethics Review Committee approval and informed consent: an analysis of biomedical publications originating from Sri Lanka

    Directory of Open Access Journals (Sweden)

    Siriwardhana Chesmal


    Full Text Available Abstract Background International guidelines on research have focused on protecting research participants. Ethical Research Committee (ERC approval and informed consent are the cornerstones. Externally sponsored research requires approval through ethical review in both the host and the sponsoring country. This study aimed to determine to what extent ERC approval and informed consent procedures are documented in locally and internationally published human subject research carried out in Sri Lanka. Methods We obtained ERC approval in Sri Lanka and the United Kingdom. Theses from 1985 to 2005 available at the Postgraduate Institute of Medicine (PGIM library affiliated to the University of Colombo were scrutinised using checklists agreed in consultation with senior research collaborators. A Medline search was carried out with MeSH major and minor heading 'Sri Lanka' as the search term for international publications originating in Sri Lanka during 1999 to 2004. All research publications from CMJ during 1999 to 2005 were also scrutinized. Results Of 291 theses, 34% documented ERC approvals and 61% documented obtaining consent. From the international journal survey, 250 publications originated from Sri Lanka of which only 79 full text original research publications could be accessed electronically. Of these 38% documented ERC approval and 39% documented obtaining consent. In the Ceylon Medical Journal 36% documented ERC approval and 37% documented obtaining consent. Conclusion Only one third of the publications scrutinized recorded ERC approval and procurement of informed consent. However, there is a positive trend in documenting these ethical requirements in local postgraduate research and in the local medical journal.

  3. 25 CFR 291.13 - When do Class III gaming procedures for an Indian tribe become effective? (United States)


    ... 25 Indians 1 2010-04-01 2010-04-01 false When do Class III gaming procedures for an Indian tribe... ECONOMIC ENTERPRISES CLASS III GAMING PROCEDURES § 291.13 When do Class III gaming procedures for an Indian tribe become effective? Upon approval of Class III gaming procedures for the Indian tribe under...

  4. All About Alternatives (United States)

    Barr, Robert D.; And Others


    A primer on alternative schools. Described are existing programs in different areas, philosophy of the alternative schools, funding, student behavior, community relations, accountability, State regulations, management, and the environment of the alternative school. A list of sources of additional information on alternative schools is included.…

  5. 78 FR 79408 - Agency Information Collection Activities; Notice of Intent To Renew Collection: Procedural... (United States)


    ... From the Federal Register Online via the Government Publishing Office COMMODITY FUTURES TRADING COMMISSION Agency Information Collection Activities; Notice of Intent To Renew Collection: Procedural... Register whenever it seeks to renew a collection of information previously ] approved by OMB,...

  6. Ultrasound-guided interventional procedures around the shoulder. (United States)

    Messina, Carmelo; Banfi, Giuseppe; Orlandi, Davide; Lacelli, Francesca; Serafini, Giovanni; Mauri, Giovanni; Secchi, Francesco; Silvestri, Enzo; Sconfienza, Luca Maria


    Ultrasound is an established modality for shoulder evaluation, being accurate, low cost and radiation free. Different pathological conditions can be diagnosed using ultrasound and can be treated using ultrasound guidance, such as degenerative, traumatic or inflammatory diseases. Subacromial-subdeltoid bursitis is the most common finding on ultrasound evaluation for painful shoulder. Therapeutic injections of corticosteroids are helpful to reduce inflammation and pain. Calcific tendinopathy of rotator cuff affects up to 20% of painful shoulders. Ultrasound-guided treatment may be performed with both single- and double-needle approach. Calcific enthesopathy, a peculiar form of degenerative tendinopathy, is a common and mostly asymptomatic ultrasound finding; dry needling has been proposed in symptomatic patients. An alternative is represented by autologous platelet-rich plasma injections. Intra-articular injections of the shoulder can be performed in the treatment of a variety of inflammatory and degenerative diseases with corticosteroids or hyaluronic acid respectively. Steroid injections around the long head of the biceps brachii tendon are indicated in patients with biceps tendinopathy, reducing pain and humeral tenderness. The most common indication for acromion-clavicular joint injection is degenerative osteoarthritis, with ultrasound representing a useful tool in localizing the joint space and properly injecting various types of drugs (steroids, lidocaine or hyaluronic acid). Suprascapular nerve block is an approved treatment for chronic shoulder pain non-responsive to conventional treatments as well as candidate patients for shoulder arthroscopy. This review provides an overview of these different ultrasonography-guided procedures that can be performed around the shoulder.

  7. Meta-analysis of the technical performance of an imaging procedure: guidelines and statistical methodology. (United States)

    Huang, Erich P; Wang, Xiao-Feng; Choudhury, Kingshuk Roy; McShane, Lisa M; Gönen, Mithat; Ye, Jingjing; Buckler, Andrew J; Kinahan, Paul E; Reeves, Anthony P; Jackson, Edward F; Guimaraes, Alexander R; Zahlmann, Gudrun


    Medical imaging serves many roles in patient care and the drug approval process, including assessing treatment response and guiding treatment decisions. These roles often involve a quantitative imaging biomarker, an objectively measured characteristic of the underlying anatomic structure or biochemical process derived from medical images. Before a quantitative imaging biomarker is accepted for use in such roles, the imaging procedure to acquire it must undergo evaluation of its technical performance, which entails assessment of performance metrics such as repeatability and reproducibility of the quantitative imaging biomarker. Ideally, this evaluation will involve quantitative summaries of results from multiple studies to overcome limitations due to the typically small sample sizes of technical performance studies and/or to include a broader range of clinical settings and patient populations. This paper is a review of meta-analysis procedures for such an evaluation, including identification of suitable studies, statistical methodology to evaluate and summarize the performance metrics, and complete and transparent reporting of the results. This review addresses challenges typical of meta-analyses of technical performance, particularly small study sizes, which often causes violations of assumptions underlying standard meta-analysis techniques. Alternative approaches to address these difficulties are also presented; simulation studies indicate that they outperform standard techniques when some studies are small. The meta-analysis procedures presented are also applied to actual [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) test-retest repeatability data for illustrative purposes.

  8. 32 CFR 552.77 - Suspension approval. (United States)


    ... 32 National Defense 3 2010-07-01 2010-07-01 true Suspension approval. 552.77 Section 552.77 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND....77 Suspension approval. The installation commander will personally approve all cases in...

  9. 40 CFR 123.61 - Approval process. (United States)


    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Approval process. 123.61 Section 123... REQUIREMENTS Program Approval, Revision, and Withdrawal § 123.61 Approval process. (a) After determining that a...; and (6) Briefly outline the fundamental aspects of the State's proposed program, and the process...

  10. 40 CFR 145.31 - Approval process. (United States)


    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Approval process. 145.31 Section 145.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS Program Approval, Revision and Withdrawal § 145.31 Approval process....

  11. Innovative and Alternative Technology Assessment Manual

    Energy Technology Data Exchange (ETDEWEB)



    This four chapter, six appendix manual presents the procedures and methodology as well as the baseline costs and energy information necessary for the analysis and evaluation of innovative and alternative technology applications submitted for federal grant assistance under the innovative and alternative technology provisions of the Clean Water Act of 1977. The manual clarifies and interprets the intent of Congress and the Environmental Protection Agency in carrying out the mandates of the innovative and alternative provisions of the Clean Water Act of 1977. [DJE 2005

  12. Hunan Rare Earth Group Approved

    Institute of Scientific and Technical Information of China (English)


    <正>Following Guangdong,Guangxi,Fujian and Jiangxi,Hunan announced that it would consolidate its rare earth resources-the consolidation plan of Hunan Rare Earth Group has been approved. Consolidation of the rare earth industry of south China is in full swing.According to "Several Opinions of the State Council on Promoting the Sustainable and Healthy Development of Rare Earth Industry"(hereinafter referred to as "Several Opinions")released in 2011,

  13. Nelfinavir: fourth protease inhibitor approved. (United States)


    The Food and Drug Administration (FDA) has granted accelerated approval to nelfinavir in both adult and pediatric formulations. Agouron, the manufacturer, used innovative computerized drug design techniques to discover, design, and refine the nelfinavir molecule. Nelfinavir is marketed under the trade name Viracept, and costs $5,000 per year. Early clinical trials find it to be as powerful as the other protease inhibitors, but with a different resistance profile. The drug has relatively few drug indications; however, several compounds have been contraindicated.

  14. 40 CFR 51.357 - Test procedures and standards. (United States)


    ... as to whether each subject device is present and appears to be properly connected and appears to be... measurement using a constant volume sampler (or an Administrator-approved alternative methodology for... standards. HC, CO, and CO+CO2 (or CO2 alone) emission standards shall be applicable to all vehicles...

  15. Bariatric Surgery Procedures (United States)

    ... Center Access to Care Toolkit EHB Access Toolkit Bariatric Surgery Procedures Bariatric surgical procedures cause weight loss by ... Bariatric procedures also often cause hormonal changes. Most weight loss surgeries today are performed using minimally invasive techniques (laparoscopic ...

  16. Alaska Regional Energy Resources Planning Project. Phase 2: coal, hydroelectric and energy alternatives. Volume I. Beluga Coal District Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rutledge, G.; Lane, D.; Edblom, G.


    This volume deals with the problems and procedures inherent in the development of the Beluga Coal District. Socio-economic implications of the development and management alternatives are discussed. A review of permits and approvals necessary for the initial development of Beluga Coal Field is presented. Major land tenure issues in the Beluga Coal District as well as existing transportation routes and proposed routes and sites are discussed. The various coal technologies which might be employed at Beluga are described. Transportation options and associated costs of transporting coal from the mine site area to a connecting point with a major, longer distance transportation made and of transporting coal both within and outside (exportation) the state are discussed. Some environmental issues involved in the development of the Beluga Coal Field are presented. (DMC)

  17. Consumer Health: Alternative Therapy (United States)

    Healthy Lifestyle Consumer health What's considered an alternative therapy is a moving target. Get the facts about what CAM means and ... Original article: . Mayo ...

  18. 76 FR 64825 - Approval and Promulgation of Air Quality Implementation Plans, Ohio and Indiana; Redesignation of... (United States)


    ... measures include the following: i. Alternative fuel and diesel retrofit programs for fleet vehicle..., Florida). Ohio and Indiana both have approved transportation conformity SIPs (72 FR 20945 (Ohio) and 75 FR... to reduce the sulfur content of diesel fuel used by highway vehicles to 15 ppm beginning in...

  19. 75 FR 42342 - Approval and Disapproval and Promulgation of Air Quality Implementation Plans; Colorado... (United States)


    ... units ducting to a common stack. Emissions are to be calculated on a pound per million British thermal... alternative performance test methods may be used with approval from the State. It also specified that ASTM or... limits by using actual hours of operations as an averaging time when the facility does not operate for...

  20. 75 FR 57296 - Proposed Extension of the Approval of Information Collection Requirements (United States)


    ... Budget (OMB) approval of the Information Collection: Disclosures to Workers Under the Migrant and... materials in alternative formats. SUPPLEMENTARY INFORMATION: I. Background Various sections of the Migrant...), 1831(c) and Regulations 29 CFR 500.80(a), require each FLC, AGER and AGAS that employs any migrant...

  1. 75 FR 3758 - Proposed Extension of the Approval of Information Collection Requirements (United States)


    ... (OMB) approval of the Information Collection: Motor Vehicle Safety for Transportation of Migrant and... alternative formats. SUPPLEMENTARY INFORMATION: I. Background Migrant and Seasonal Agricultural Worker... vehicle they use or cause to be used to transport or drive any migrant or seasonal agricultural...

  2. Still special? Harvesting procedures for industrial hemp

    Directory of Open Access Journals (Sweden)

    Hans-Jörg Gusovius


    Full Text Available A multitude of different harvesting procedures is available after the re-approval of hemp growing in Germany about 20 years ago. Established, but as well recent machine developments enable the supply of raw materials for further processing or as food and feed materials. The necessary specialization level results in high but, compared to other established crops, not exceeding procedural costs. In this study, harvesting procedures and technologies are analyzed that are currently used under Northern European cultivation conditions. However, technological enhancements are still needed in order to improve the competitiveness of fibre hemp in the crop rotation as well as of hemp-based semi-finished and finished products.

  3. 17 CFR 140.24 - Control and accountability procedures. (United States)


    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Control and accountability... ORGANIZATION, FUNCTIONS, AND PROCEDURES OF THE COMMISSION Functions § 140.24 Control and accountability... accountability for such information at all times and for locking classified information in approved...

  4. 40 CFR 610.64 - Track test procedures. (United States)


    ... either a volumetric or gravimetric procedure approved by the Administrator. (5) Vehicle speed and... truck or trailer. (4) Fuel economy will be determined by either a gravimetric or volumetric method. (c... in dynamometer tests (§ 610.43(b)). Fuel economy will be measured by gravimetric or...

  5. 76 FR 61689 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment... (United States)


    ... and approval according to the procedures prescribed in 5 CFR 1320.12. On March 16, 2011 (76 FR 14390... (WPS), codified at 40 CFR part 170, established requirements to protect agricultural workers and... party response burden from complying with the WPS requirements. Information is exchanged...

  6. 76 FR 11451 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment... (United States)


    ... estate sales and residential property rentals involving target housing subject to the rule's requirements... and approval according to the procedures prescribed in 5 CFR 1320.12. On October 27, 2010 (75 FR 66087.... 4852d) requires that sellers and lessors of most residential housing built before 1978 disclose...

  7. 78 FR 41974 - Agency Information Collection Activities: Requests for Comments; Clearance of a Renewed Approval... (United States)


    ... Renewed Approval of Information Collection(s): Procedures for Transportation Workplace Drug and Alcohol... tests conducted and actions taken to ensure safety in the workplace and/or is necessary because under... notice in the Federal Register in accordance with the Paperwork Reduction Act of 1995, Public Law...

  8. 76 FR 20804 - Agency Information Collection Activities: Requests for Comments; Clearance of a Renewed Approval... (United States)


    ... Renewed Approval of Information Collection(s): Procedures for Transportation Workplace Drug and Alcohol... tests conducted and actions taken to ensure safety in the workplace and/or is necessary because under... notice in the Federal Register in accordance with the Paperwork Reduction Act of 1995, Public Law...

  9. 14 CFR 21.502 - Approval of materials, parts, and appliances. (United States)


    ... TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Approval of Engines, Propellers..., Propellers, and Articles for Import § 21.500 Acceptance of aircraft engines and propellers. An aircraft... product furnishes with each such aircraft engine or propeller imported into the United States, an...

  10. 78 FR 15895 - Approval and Promulgation of Air Quality Implementation Plans: North Carolina; Control Techniques... (United States)


    ... 2D, .0521, .0614, NCAC 2Q .0102, .0304, and .0902. These rules address Air Pollution Control, Emission Control Standards, Monitoring and Recordkeeping and Air Quality Permit Procedures and are not... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans: North...

  11. 75 FR 67388 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval (United States)


    ...-8000; telephone (202) 708-2830 (this is not a toll-free number). Persons with hearing or speech... published a notice (64 FR 26769), on its procedures for terminating Origination Approval Agreements with FHA... Freedom Mortgage Corp......... 907 Pleasant Valley Fort Worth....... 10/4/10 Denver. Ave. Mount Laurel,...

  12. 13 CFR 127.304 - How does a concern obtain certification from an approved certifier? (United States)


    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How does a concern obtain certification from an approved certifier? 127.304 Section 127.304 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT ASSISTANCE PROCEDURES Certification of EDWOSB or...

  13. 13 CFR 127.303 - How will SBA select and identify approved certifiers? (United States)


    ... approved certifiers? 127.303 Section 127.303 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT ASSISTANCE PROCEDURES Certification of EDWOSB or WOSB Status... small business concern under SBA's size standards for its primary industry classification; (ii) At...

  14. 15 CFR 27.111 - Criteria for IRB approval of research. (United States)


    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Criteria for IRB approval of research. 27.111 Section 27.111 Commerce and Foreign Trade Office of the Secretary of Commerce PROTECTION OF...) Risks to subjects are minimized: (i) By using procedures which are consistent with sound research...

  15. Selection and evaluation of alternative solvents for caprolactam extraction

    NARCIS (Netherlands)

    Delden, van Mathijs L.; Kuipers, Norbert J.M.; Haan, de André B.


    Because of the strict legislation for currently applied solvents in the industrial extraction of caprolactam, being benzene, toluene and chlorinated hydrocarbons, a need exists for alternative, environmentally benign solvents. An experimental screening procedure consisting of several steps was used

  16. Repurposing of approved cardiovascular drugs. (United States)

    Ishida, Junichi; Konishi, Masaaki; Ebner, Nicole; Springer, Jochen


    Research and development of new drugs requires both long time and high costs, whereas safety and tolerability profiles make the success rate of approval very low. Drug repurposing, applying known drugs and compounds to new indications, has been noted recently as a cost-effective and time-unconsuming way in developing new drugs, because they have already been proven safe in humans. In this review, we discuss drug repurposing of approved cardiovascular drugs, such as aspirin, beta-blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, cardiac glycosides and statins. Regarding anti-tumor activities of these agents, a number of experimental studies have demonstrated promising pleiotropic properties, whereas all clinical trials have not shown expected results. In pathological conditions other than cancer, repurposing of cardiovascular drugs is also expanding. Numerous experimental studies have reported possibilities of drug repurposing in this field and some of them have been tried for new indications ('bench to bedside'), while unexpected results of clinical studies have given hints for drug repurposing and some unknown mechanisms of action have been demonstrated by experimental studies ('bedside to bench'). The future perspective of experimental and clinical studies using cardiovascular drugs are also discussed.

  17. 7 CFR 799.11 - Expedited procedures. (United States)


    ... AGRICULTURE ENVIRONMENTAL PROTECTION ENVIRONMENTAL QUALITY AND RELATED ENVIRONMENTAL CONCERNS-COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 799.11 Expedited procedures. Where emergency circumstances... Environmental Quality, consult with CEQ and/or EPA about alternative arrangements (7 CFR 3100.35)....

  18. Alternative systematic approaches to training

    Energy Technology Data Exchange (ETDEWEB)


    This handbook is approved for use by all DOE Components and contractors. The handbook was prepared primarily for DOE nuclear facilities, but the information can be effectively used by any other type of facility. DOE nuclear, DOE non-nuclear, commercial nuclear reactor, fuel fabrication, chemical processing, or other types of facilities may also apply the principles of this approach and find it useful and applicable to local needs. The handbook provides DOE and contractor operating organizations with concepts and guidance regarding the use of alternative techniques to implement a systematic approach to training (SAT). The techniques described in this handbook are endorsed by DOE and use of the guidance in this handbook is appropriate for establishment of technical training programs at DOE nuclear facilities. The use of guidance on selection and implementation of appropriate training approaches after consideration of job complexity, the consequences of error based on risk/hazard potential, and available training media should result in effective and efficient training programs. The information presented in this handbook can be used to grade the level of effort and formality used in developing training programs.

  19. OMB Recommended vs Approved Operating Budget (United States)

    Montgomery County of Maryland — This dataset includes the Fiscal Year 2015 County Executive Recommended and County Council Approved operating budgets for Montgomery County, for comparison purposes....

  20. Marketing Approval of Ethical Kampo Medicines. (United States)

    Hakamatsuka, Takashi


     Kampo medicine is an original traditional medicine in Japan. Currently, 148 ethical Kampo formulations (Kampo prescription drugs) are registered in the National Health Insurance Price List. Kampo medicines can be prescribed under the national insurance system, which shows that they are part of conventional medicine in Japan. Japan has a unified drug approval system that does not distinguish between Western and Kampo medicines, and both are subject to the same regulations. The application for the market approval of ethical Kampo medicines is based on the general notification for drugs, i.e., "Handling of Ethical Combination Drugs" in "Precautions Necessary When Applying for Drug Marketing Approval" (Yakushokushinsa Notification No. 1121-12 of November 21, 2014). Furthermore, applications for the market approval of ethical Kampo medicines should follow the Kampo-specific notification of "Handling of Ethical Kampo Medicines" (Yakushin Notification No. 804 of June 25, 1980). Data from comparative studies with standard decoctions must be submitted with approval applications according to Yakushin 2 Notification No. 120 of May 31, 1985. The safety, efficacy, and quality of Kampo medicines are comprehensively assured by the Japanese Pharmacopoeia, Good Manufacturing Practice, Good Agricultural and Collection Practices, marketing approval certificate, approval standard, and pharmacovigilance. I believe that the basic framework for the market approval of ethical Kampo medicines has been established as described above. The key factors for the practical application of superior manufacturing technology and research achievements and the promotion of drug development are the specific guidelines for the approval of drugs of herbal origin.

  1. On alternating quantum walks (United States)

    Rousseva, Jenia; Kovchegov, Yevgeniy


    We study an inhomogeneous quantum walk on a line that evolves according to alternating coins, each a rotation matrix. For the quantum walk with the coin alternating between clockwise and counterclockwise rotations by the same angle, we derive a closed form solution for the propagation of probabilities, and provide its asymptotic approximation via the method of stationary phase. Finally, we observe that for a x03c0;/4 angle, this alternating rotation walk will replicate the renown Hadamard walk.

  2. Alternative Solar Indices

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, L.J.


    Possible alternative Solar Indices which could either be a perturbation from the currently defined Solar Index or possible indices based on current technologies for other media markets are discussed. An overview is given of the current project, including the logic that was utilized in defining its current structure and then alternative indices and definitions are presented and finally, recommendations are made for adopting alternative indices.

  3. On an Alternative Cosmology

    CERN Document Server

    Vankov, A


    The suggested alternative cosmology is based on the idea of barion symmetric universe, in which our home universe is a representative of multitude of typical matter and antimatter universes. This alternative concept gives a physically reasonable explanation of all major problems of the Standard Cosmological Model. Classification Code MSC: Cosmology 524.8 Key words: standard cosmological model, alternative cosmology, barionic symmetry, typical universe, quasars, cosmic rays.

  4. 30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification... (United States)


    ... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Machines Assembled With Certified or Explosion-Proof Components, Field Modifications of Approved Machines... and Certification Center, 765 Technology Drive, Triadelphia, WV 26059. (b) Proposed...

  5. Brandmodstandsbidrag for alternative isoleringsmaterialer

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place


    Resume af rapport om alternative isoleringsmaterialers brandmodstandsbidrag, udarbejdet af Dansk Brandteknisk Institut under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"...

  6. Computerized procedures system (United States)

    Lipner, Melvin H.; Mundy, Roger A.; Franusich, Michael D.


    An online data driven computerized procedures system that guides an operator through a complex process facility's operating procedures. The system monitors plant data, processes the data and then, based upon this processing, presents the status of the current procedure step and/or substep to the operator. The system supports multiple users and a single procedure definition supports several interface formats that can be tailored to the individual user. Layered security controls access privileges and revisions are version controlled. The procedures run on a server that is platform independent of the user workstations that the server interfaces with and the user interface supports diverse procedural views.

  7. The Growth of Alternative Public Schools: The 1975 ICOPE Report. (United States)

    Barr, Robert D.


    This newsletter reports the growth of alternative schools from 1973 when 464 alternative public schools in 36 states were identified to 1975 when 1,250 such schools can be listed. Charts illustrate the growth distributed by states. The reasons for growth are presented as publications, professional recommendations, accreditation procedures, state…

  8. Hom-alternative algebras and Hom-Jordan algebras

    CERN Document Server

    Makhlouf, Abdenacer


    The purpose of this paper is to introduce Hom-alternative algebras and Hom-Jordan algebras. We discuss some of their properties and provide construction procedures using ordinary alternative algebras or Jordan algebras. Also, we show that a polarization of Hom-associative algebra leads to Hom-Jordan algebra.

  9. 40 CFR 1033.520 - Alternative ramped modal cycles. (United States)


    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Alternative ramped modal cycles. 1033.520 Section 1033.520 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM LOCOMOTIVES Test Procedures § 1033.520 Alternative ramped...

  10. 12 CFR 211.24 - Approval of offices of foreign banks; procedures for applications; standards for approval... (United States)


    ... with customers or potential customers, beyond incidental contact with existing customers relating to..., projected capital position, profitability, level of indebtedness, and future prospects) and the condition of...; conducting research; acting as liaison between the foreign bank's head office and customers in the...

  11. Statistical Cost Estimation in Higher Education: Some Alternatives. (United States)

    Brinkman, Paul T.; Niwa, Shelley

    Recent developments in econometrics that are relevant to the task of estimating costs in higher education are reviewed. The relative effectiveness of alternative statistical procedures for estimating costs are also tested. Statistical cost estimation involves three basic parts: a model, a data set, and an estimation procedure. Actual data are used…

  12. Alternative Schools, Mainstream Education (United States)

    McKee, Jan; Conner, Evguenia


    Alternative education has its own history. Having emerged in the sixties as a response to the social crisis, its goal was primarily to fight increasing bureaucracy and the depersonalization of public education by giving students more freedom and minimal adult supervision. In the eighties, the understanding of "alternative education" narrowed to…

  13. Alternative Fuels Data Center

    Energy Technology Data Exchange (ETDEWEB)



    Fact sheet describes the Alternative Fuels Data Center, which provides information, data, and tools to help fleets and other transportation decision makers find ways to reduce petroleum consumption through the use of alternative and renewable fuels, advanced vehicles, and other fuel-saving measures.

  14. Acquisition of Voicing Alternations

    NARCIS (Netherlands)

    Kerkhoff, Annemarie


    "Morpho-phonological alternations are central to phonological theory, but little is known about how they are acquired. Acquiring alternations amounts to dealing with variation in a morpheme’s shape depending on its morphological context. It is generally assumed that children start with an initial st

  15. Alternative health insurance schemes

    DEFF Research Database (Denmark)

    Keiding, Hans; Hansen, Bodil O.


    In this paper, we present a simple model of health insurance with asymmetric information, where we compare two alternative ways of organizing the insurance market. Either as a competitive insurance market, where some risks remain uninsured, or as a compulsory scheme, where however, the level...... competitive insurance; this situation turns out to be at least as good as either of the alternatives...

  16. Conflict among Testing Procedures? (United States)


    AM4ONG TESTING PROCEDURES? Daniel F . Kohler April 1982 ( i’ 4:3 rpis tsnlb u lailtsd P-6765 8 8 O1 V 068 The Rand Paper Series Papers are issued by...TESTING PROCEDURES? Daniel F . Kohler April 1982 : i ! ,I I CONFLICT AMONG TESTING PROCEDURES? 1. Introduction "- Savin [1976] and Berndt and Savin [19771

  17. 40 CFR 52.1323 - Approval status. (United States)


    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Approval status. 52.1323 Section 52.1323 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... on January 16, 1979 (44 FR 3274) are met. (b) The Administrator approves Rule 10 CSR 10-2.290...

  18. Obinutuzumab breaks through to FDA approval. (United States)


    The U.S. Food and Drug Administration approved the monoclonal antibody obinutuzumab for use with chlorambucil in patients with previously untreated chronic lymphocytic leukemia. The drug is the first to receive approval under the agency's breakthrough therapy designation, created in July 2012.

  19. 46 CFR 154.1005 - Equipment approval. (United States)


    ... carried. (b) Each submerged cargo pump motor installation must be specially approved by the Commandant (CG... FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and Equipment Electrical § 154.1005 Equipment approval. (a) Electrical equipment that is required to be intrinsically safe...

  20. 24 CFR 214.103 - Approval criteria. (United States)


    ... counseling staff must possess a working knowledge of HUD's housing and single-family mortgage insurance... COUNSELING PROGRAM Approval and Disapproval of Housing Counseling Agencies § 214.103 Approval criteria. The... counseling agencies, branches, and affiliates that are included in one application: (a) Nonprofit and...

  1. 38 CFR 21.7220 - Course approval. (United States)


    ...; Pub. L. 98-525) (b) Course approval criteria. In administering benefits payable under 38 U.S.C.... (1) Section 21.4250 (except paragraph (c)(1))—Jurisdiction for course and licensing and certification... study; and (12) Section 21.4268—Approval of licensing and certification tests. (Authority: 38...

  2. An alternative to Zoe's Law. (United States)

    Dalmau, James


    Under the criminal law of New South Wales, the destruction of a foetus (other than in the course of a medical procedure) constitutes grievous bodily harm to the pregnant woman. Charges can be laid for offences against the woman, but not against the foetus. Many are dissatisfied with this. The Crimes Amendment (Zoe's Law) Bill 2013 (No 2) (NSW) aimed to change this by providing that a foetus is taken to be a living person for the purposes of certain offences. The Bill was strongly opposed on the basis that according personhood to a foetus in this way will have undesirable consequences that could erode the reproductive rights of women. The public debate over how the criminal law addresses the destruction of a foetus has centred on Zoe's Law. This article proposes an alternative amendment. that aims, to accommodate the concerns of the Bill's supporters and its detractors.

  3. National Differences in Requirements for Ethical and Competent Authority Approval for a Multinational Vaccine Trial under the EU Directive 2001/20/EC

    Directory of Open Access Journals (Sweden)

    Eva van Doorn


    Full Text Available Obtaining approval for a multinational vaccine trial from an ethics committee and the national competent authority of different Member States of the European Union (EU is challenging under clinical trial Directive 2001/20/EC because of the differences in the implementation of the directive in national laws of Member States. In this review the national differences in requirements for ethical and competent authority approval are illustrated. The national ethical and competent authority review procedures in Finland, Hungary, The Netherlands, Norway and Slovenia are described under the EU trial directive after discussing the provisions of the trial directive related to both review procedures. The review illustrates the differences between the countries in the documents that have to be submitted for the review procedures, the submission procedures and the language requirements of the documents, the organization of the ethics committees and the role of the competent authority in the approval procedure.

  4. In-Trail Procedure Air Traffic Control Procedures Validation Simulation Study (United States)

    Chartrand, Ryan C.; Hewitt, Katrin P.; Sweeney, Peter B.; Graff, Thomas J.; Jones, Kenneth M.


    In August 2007, Airservices Australia (Airservices) and the United States National Aeronautics and Space Administration (NASA) conducted a validation experiment of the air traffic control (ATC) procedures associated with the Automatic Dependant Surveillance-Broadcast (ADS-B) In-Trail Procedure (ITP). ITP is an Airborne Traffic Situation Awareness (ATSA) application designed for near-term use in procedural airspace in which ADS-B data are used to facilitate climb and descent maneuvers. NASA and Airservices conducted the experiment in Airservices simulator in Melbourne, Australia. Twelve current operational air traffic controllers participated in the experiment, which identified aspects of the ITP that could be improved (mainly in the communication and controller approval process). Results showed that controllers viewed the ITP as valid and acceptable. This paper describes the experiment design and results.

  5. HL-LHC alternatives

    CERN Document Server

    Tomás, R; White, S


    The HL-LHC parameters assume unexplored regimes for hadron colliders in various aspects of accelerator beam dynamics and technology. This paper reviews three alternatives that could potentially improve the LHC performance: (i) the alternative filling scheme 8b+4e, (ii) the use of a 200 MHz RF system in the LHC and (iii) the use of proton cooling methods to reduce the beam emittance (at top energy and at injection). The alternatives are assessed in terms of feasibility, pros and cons, risks versus benefits and the impact on beam availability.

  6. Alternative loop rings

    CERN Document Server

    Goodaire, EG; Polcino Milies, C


    For the past ten years, alternative loop rings have intrigued mathematicians from a wide cross-section of modern algebra. As a consequence, the theory of alternative loop rings has grown tremendously. One of the main developments is the complete characterization of loops which have an alternative but not associative, loop ring. Furthermore, there is a very close relationship between the algebraic structures of loop rings and of group rings over 2-groups. Another major topic of research is the study of the unit loop of the integral loop ring. Here the interaction between loop rings and group ri

  7. Purification of Carbon Nanotubes: Alternative Methods (United States)

    Files, Bradley; Scott, Carl; Gorelik, Olga; Nikolaev, Pasha; Hulse, Lou; Arepalli, Sivaram


    Traditional carbon nanotube purification process involves nitric acid refluxing and cross flow filtration using surfactant TritonX. This is believed to result in damage to nanotubes and surfactant residue on nanotube surface. Alternative purification procedures involving solvent extraction, thermal zone refining and nitric acid refiuxing are used in the current study. The effect of duration and type of solvent to dissolve impurities including fullerenes and P ACs (polyaromatic compounds) are monitored by nuclear magnetic reasonance, high performance liquid chromatography, and thermogravimetric analysis. Thermal zone refining yielded sample areas rich in nanotubes as seen by scanning electric microscopy. Refluxing in boiling nitric acid seem to improve the nanotube content. Different procedural steps are needed to purify samples produced by laser process compared to arc process. These alternative methods of nanotube purification will be presented along with results from supporting analytical techniques.

  8. Comparing Error Correction Procedures for Children Diagnosed with Autism (United States)

    Townley-Cochran, Donna; Leaf, Justin B.; Leaf, Ronald; Taubman, Mitchell; McEachin, John


    The purpose of this study was to examine the effectiveness of two error correction (EC) procedures: modeling alone and the use of an error statement plus modeling. Utilizing an alternating treatments design nested into a multiple baseline design across participants, we sought to evaluate and compare the effects of these two EC procedures used to…

  9. 21 CFR 1010.13 - Special test procedures. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Special test procedures. 1010.13 Section 1010.13 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) RADIOLOGICAL HEALTH PERFORMANCE STANDARDS FOR ELECTRONIC PRODUCTS: GENERAL Alternate Test Procedures §...

  10. Ultrasound-guided interventional procedures around the shoulder (United States)

    Messina, Carmelo; Banfi, Giuseppe; Orlandi, Davide; Lacelli, Francesca; Serafini, Giovanni; Mauri, Giovanni; Secchi, Francesco; Silvestri, Enzo


    Ultrasound is an established modality for shoulder evaluation, being accurate, low cost and radiation free. Different pathological conditions can be diagnosed using ultrasound and can be treated using ultrasound guidance, such as degenerative, traumatic or inflammatory diseases. Subacromial–subdeltoid bursitis is the most common finding on ultrasound evaluation for painful shoulder. Therapeutic injections of corticosteroids are helpful to reduce inflammation and pain. Calcific tendinopathy of rotator cuff affects up to 20% of painful shoulders. Ultrasound-guided treatment may be performed with both single- and double-needle approach. Calcific enthesopathy, a peculiar form of degenerative tendinopathy, is a common and mostly asymptomatic ultrasound finding; dry needling has been proposed in symptomatic patients. An alternative is represented by autologous platelet-rich plasma injections. Intra-articular injections of the shoulder can be performed in the treatment of a variety of inflammatory and degenerative diseases with corticosteroids or hyaluronic acid respectively. Steroid injections around the long head of the biceps brachii tendon are indicated in patients with biceps tendinopathy, reducing pain and humeral tenderness. The most common indication for acromion–clavicular joint injection is degenerative osteoarthritis, with ultrasound representing a useful tool in localizing the joint space and properly injecting various types of drugs (steroids, lidocaine or hyaluronic acid). Suprascapular nerve block is an approved treatment for chronic shoulder pain non-responsive to conventional treatments as well as candidate patients for shoulder arthroscopy. This review provides an overview of these different ultrasonography-guided procedures that can be performed around the shoulder. PMID:26313499

  11. Alternative disinfectant water treatments (United States)

    Alternative disinfestant water treatments are disinfestants not as commonly used by the horticultural industry. Chlorine products that produce hypochlorous acid are the main disinfestants used for treating irrigation water. Chlorine dioxide will be the primary disinfestant discussed as an alternativ...

  12. Alternative fuel information sources

    Energy Technology Data Exchange (ETDEWEB)


    This short document contains a list of more than 200 US sources of information (Name, address, phone number, and sometimes contact) related to the use of alternative fuels in automobiles and trucks. Electric-powered cars are also included.

  13. Seal design alternatives study

    Energy Technology Data Exchange (ETDEWEB)

    Van Sambeek, L.L. [RE/SPEC Inc., Rapid City, SD (US); Luo, D.D.; Lin, M.S.; Ostrowski, W.; Oyenuga, D. [Parsons Brinckerhoff Quade & Douglas, Inc., San Francisco, CA (US)


    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information.

  14. Alternatives to Nursing Homes (United States)

    ... this website may not be available. Alternatives to nursing homes Before you make any decisions about long ... live and what help you may need. A nursing home may not be your only choice. Discharge ...

  15. Breast Reconstruction Alternatives (United States)

    ... Breast Reconstruction Surgery Breast Cancer Breast Reconstruction Surgery Breast Reconstruction Alternatives Some women who have had a ... chest. What if I choose not to get breast reconstruction? Some women decide not to have any ...

  16. Vaginal dryness alternative treatments (United States)

    Alternative treatments for vaginal dryness ... Question: Is there a drug-free treatment for vaginal dryness? Answer: There are many causes of vaginal dryness . It may be caused by reduced estrogen level, infection, medicines, and ...

  17. Doctors Look for Liver Transplant Alternatives

    Institute of Scientific and Technical Information of China (English)


    @@ Robert Pennington, a 19 - year - old boy, suffers from liver disease. His name was put on a transplant waiting list, but no livers were available. Then Dr. Marlon Levy, a transplant surgeon at Baylor University Medical Center, offered an alternative: a procedure2 using a dead pig's liver. But not a liver from an ordinary pig, "They're genetically modified3 to try to prevent a reaction between the human blood and the pig liver" , Levy said.

  18. Biologic Joint Reconstruction: Alternatives to Arthroplasty


    Cole, Brian J.; Andreas H. Gmoll


    A comprehensive source of information in the management of cartilage lesions of major joints using nonoperative or surgical techniques other than total joint replacement. The text also includes chapters in basic sciences, imaging and rehabilitation.The editors are aiming to provide a reference about the latest concepts and techniques in the treatment of cartilage lesions including future aspects by a comprehensive approach to the alternative joint restoration procedures such as biological, ph...

  19. Finite element procedures

    CERN Document Server

    Bathe, Klaus-Jürgen


    Finite element procedures are now an important and frequently indispensable part of engineering analyses and scientific investigations. This book focuses on finite element procedures that are very useful and are widely employed. Formulations for the linear and nonlinear analyses of solids and structures, fluids, and multiphysics problems are presented, appropriate finite elements are discussed, and solution techniques for the governing finite element equations are given. The book presents general, reliable, and effective procedures that are fundamental and can be expected to be in use for a long time. The given procedures form also the foundations of recent developments in the field.

  20. Pedagogical Implications in the Thermal Analysis of Uniform Annular Fins: Alternative Analytic Solutions by Series. (United States)

    Campo, Antonio; Rodriguez, Franklin


    Presents two alternative computational procedures for solving the modified Bessel equation of zero order: the Frobenius method, and the power series method coupled with a curve fit. Students in heat transfer courses can benefit from these alternative procedures; a course on ordinary differential equations is the only mathematical background that…

  1. Alternative fuels for vehicles; Alternative drivmidler

    Energy Technology Data Exchange (ETDEWEB)


    Up until 2020 and onwards the analysis indicates that especially electricity, biogas and natural gas as propellants is economically attractive compared to conventional gasoline and diesel while other fuels have the same or higher costs for petrol and diesel. Especially biogas and electricity will also offer significant reductions in CO{sub 2} emissions, but also hydrogen, methanol, DME and to a lesser extent the second generation bioethanol and most of the other alternative fuels reduce CO{sub 2} emissions. Use of the traditional food-based first generation biofuels involves, at best, only modest climate benefits if land use changes are counted, and at worst, significant negative climate effects. Natural gas as a propellant involves a moderate climate gain, but may play a role for building infrastructure and market for gaseous fuels in large fleets, thereby contributing to the phasing in of biogas for transport. The electric-based automotive fuels are the most effective due to a high efficiency of the engine and an increasing proportion of wind energy in the electricity supply. The methanol track also has a relatively high efficiency. Among the others, the track based on diesel engines (biodiesel) is more effective than the track based on gasoline/Otto engines (gas and ethanol) as a result of the diesel engine's better efficiency. For the heavy vehicles all the selected alternative fuels to varying degrees reduce emissions of CO{sub 2}, particularly DME based on wood. The only exception to this is - as for passenger cars - the propellant synthetic diesel based on coal. (LN).

  2. Judicial civil procedure dragging out in Kosovo

    Directory of Open Access Journals (Sweden)

    Rrustem Qehaja


    Full Text Available This article tends to deal with one of the most worrying issues in the judicial system of Kosovo the problem of judicial civil procedure dragging out. The article analyses the reasons of these dragging outs of the judicial civil procedure focusing on the context of one of the basic procedural principles in civil procedure-the principle of economy or efficiency in the courts. Dragging out of civil procedure in Kosovo has put in question not only the basic principles of civil procedure, but it also challenges the general principles related to human rights and freedoms sanctioned not only by the highest legal act of the country, but also with international treaties. The article tends to give a reflection to the most important reasons that effect and influence in these dragging outs of civil procedure, as well as, at the same time aims to give the necessary alternatives to pass through them by identifying dilemmas within the judicial practice. As a result, the motives of this scientific paper are exactly focused at the same time on identifying the dilemmas, as well as presenting ideas, to overstep them, including the judicial practice of the European Court of Human Rights on Article 6 of the European Convention on Human Rights, by which it is given the possibility to offering people efficient and within a reasonable time legal protection of their rights before national courts. For these reasons, the paper elaborates this issue based on both, the legal theory and judicial practice.

  3. Drugs Approved for Colon and Rectal Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for use in colon cancer and rectal cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  4. Drugs Approved for Gestational Trophoblastic Disease (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for gestational trophoblastic disease. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  5. Drugs Approved for Head and Neck Cancer (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for head and neck cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  6. FDA Approves First Immunotherapy for Lymphoma (United States)

    The FDA has approved nivolumab (Opdivo®) for the treatment of patients with classical Hodgkin lymphoma whose disease has relapsed or worsened after receiving an autologous hematopoietic stem cell transplantation followed by brentuximab vedotin (Adcetris®)

  7. Depression: FDA-Approved Medications May Help (United States)

    ... Products For Consumers Home For Consumers Consumer Updates Depression: FDA-Approved Medications May Help Share Tweet Linkedin ... symptoms in some people. back to top Diagnosing Depression Diagnosis—which should be from a health care ...

  8. 30 CFR 7.409 - Approval marking. (United States)


    ... approval number in addition to the number and size (gauge) of conductors and cable type. For cables containing electric conductors, the marking shall also include the voltage rating. For splices, the...

  9. Drugs Approved for Kidney (Renal Cell) Cancer (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural Media ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for kidney (renal cell) cancer. The list ...

  10. Drugs Approved for Soft Tissue Sarcoma (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural Media ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for soft tissue sarcoma. The list includes ...

  11. Drugs Approved for Non-Hodgkin Lymphoma (United States)

    ... 2015 2014 2013 2012 Media Resources Media Contacts Multicultural Media ... This page lists cancer drugs approved by the Food and Drug Administration (FDA) for non-Hodgkin lymphoma. The list includes ...

  12. Cardiac Procedures and Surgeries (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Cardiac Procedures and Surgeries Updated:Sep 16,2016 If you've had ... degree of coronary artery disease (CAD) you have. Cardiac Procedures and Surgeries Angioplasty Also known as Percutaneous Coronary Interventions [PCI], ...

  13. Decision-making Procedures

    DEFF Research Database (Denmark)

    Aldashev, Gani; Kirchsteiger, Georg; Sebald, Alexander Christopher


    It is a persistent finding in psychology and experimental economics that people's behavior is not only shaped by outcomes but also by decision-making procedures. In this paper we develop a general framework capable of modelling these procedural concerns. Within the context of psychological games we...

  14. Civil Procedure In Denmark

    DEFF Research Database (Denmark)

    Werlauff, Erik

    The book contains an up-to-date survey of Danish civil procedure after the profound Danish procedural reforms in 2007. It deals with questions concerning competence and function of Danish courts, commencement and preparation of civil cases, questions of evidence and burden of proof, international...

  15. Catalysis for alternative energy generation

    CERN Document Server


    Summarizes recent problems in using catalysts in alternative energy generation and proposes novel solutions  Reconsiders the role of catalysis in alternative energy generation  Contributors include catalysis and alternative energy experts from across the globe

  16. Analysis of lomustine drug content in FDA-approved and compounded lomustine capsules. (United States)

    KuKanich, Butch; Warner, Matt; Hahn, Kevin


    OBJECTIVE To determine the lomustine content (potency) in compounded and FDA-approved lomustine capsules. DESIGN Evaluation study. SAMPLE 2 formulations of lomustine capsules (low dose [7 to 11 mg] and high dose [40 to 48 mg]; 5 capsules/dose/source) from 3 compounders and from 1 manufacturer of FDA-approved capsules. PROCEDURES Lomustine content was measured by use of a validated high-pressure liquid chromatography method. An a priori acceptable range of 90% to 110% of the stated lomustine content was selected on the basis of US Pharmacopeia guidelines. RESULTS The measured amount of lomustine in all compounded capsules was less than the stated content (range, 59% to 95%) and was frequently outside the acceptable range (failure rate, 2/5 to 5/5). Coefficients of variation for lomustine content ranged from 4.1% to 16.7% for compounded low-dose capsules and from 1.1% to 10.8% for compounded high-dose capsules. The measured amount of lomustine in all FDA-approved capsules was slightly above the stated content (range, 104% to 110%) and consistently within the acceptable range. Coefficients of variation for lomustine content were 0.5% for low-dose and 2.3% for high-dose FDA-approved capsules. CONCLUSIONS AND CLINICAL RELEVANCE Compounded lomustine frequently did not contain the stated content of active drug and had a wider range of lomustine content variability than did the FDA-approved product. The sample size was small, and larger studies are needed to confirm these findings; however, we recommend that compounded veterinary formulations of lomustine not be used when appropriate doses can be achieved with FDA-approved capsules or combinations of FDA-approved capsules.

  17. [Alternative scaffold proteins]. (United States)

    Petrovskaia, L E; Shingarova, L N; Dolgikh, D A; Kirpichnikov, M P


    Review is devoted to the challenging direction in modem molecular biology and bioengineering - the properties of alternative scaffold proteins (ASP) and methods for obtaining ASP binding molecules. ASP molecules incorporate conservative protein core and hypervariable regions, providing for the binding function. Structural classification of ASP includes several types which differ also in their molecular targets and potential applications. Construction of artificial binding proteins on the ASP basis implies a combinatorial library design with subsequent selection of specific binders with the use of phage display or the modem cell-free systems. Alternative binding proteins on non-immunoglobulin scaffolds find broad applications in different fields ofbiotechnology and molecular medicine.

  18. 36 CFR 28.15 - Approval of local zoning ordinances. (United States)


    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Approval of local zoning... INTERIOR FIRE ISLAND NATIONAL SEASHORE: ZONING STANDARDS Federal Standards and Approval of Local Ordinances § 28.15 Approval of local zoning ordinances. (a) The Secretary shall approve local ordinances...

  19. 30 CFR 35.9 - Certificates of approval. (United States)


    ... APPROVAL OF MINING PRODUCTS FIRE-RESISTANT HYDRAULIC FLUIDS General Provisions § 35.9 Certificates of approval. (a) Upon completion of an investigation of a hydraulic fluid MSHA will issue to the applicant... notification of approval will be issued. If a certificate of approval is issued, no test data or...

  20. 46 CFR 502.411 - Mediation and other alternative means of dispute resolution. (United States)


    ... 46 Shipping 9 2010-10-01 2010-10-01 false Mediation and other alternative means of dispute... PROVISIONS RULES OF PRACTICE AND PROCEDURE Alternative Dispute Resolution § 502.411 Mediation and other alternative means of dispute resolution. (a) Parties are encouraged to utilize mediation or other forms...

  1. Alternative Energy Busing (United States)

    LaFee, Scott


    In recent years, school districts have converted portions of their bus fleets to cleaner-burning, sometimes cheaper, alternative fossil fuels, such as compressed natural gas or propane. Others have adopted biodiesel, which combines regular diesel with fuel derived from organic sources, usually vegetable oils or animal fats. The number of biodiesel…

  2. Alternate dispute resolution.


    Webb, Paul F.


    In an effort to save taxpayer dollars and ease an overburdened administrative and judicial court system, this report presents evidence to encourage the use of alternate dispute resolution (ADR) in construction contracting within the Naval Facilities Engineering Command. Information is presented detailing the primary factors that contribute to this expensive and overburdened system, including: costs associated with litigation, contractual document formation, experience level ...

  3. Alternatives in solar energy (United States)

    Schueler, D. G.


    Although solar energy has the potential of providing a significant source of clean and renewable energy for a variety of applications, it is expected to penetrate the nation's energy economy very slowly. The alternative solar energy technologies which employ direct collection and conversion of solar radiation as briefly described.

  4. Environment and Alternative Development. (United States)

    Kothari, Rajni

    Stressing the global dimension to the adversary relationship between economic development and environmental conservation, this monograph examines the philosophical, historical, cultural, and ethnic underpinnings of modern science and technology. In addition, the monograph spells out policy implications of an alternative concept of development and…

  5. Complementary and Alternative Medicine (United States)

    ... the practitioner to ask about the risks and benefits of treatment — the same kinds of things you'd do if you were interviewing a new doctor. You may have already used a complementary or alternative practice, like yoga or massage, and not even thought about it! ...

  6. Alternative calcination development status report

    Energy Technology Data Exchange (ETDEWEB)

    Boardman, R.D.


    The Programmatic Spent Nuclear Fuel and (INEEL) Environmental Restoration and Waste Management Programs Environmental Impact Statement Record of Decision, dated June 1, 1995, specifies that high-level waste stored in the underground tanks at the ICPP continue to be calcined while other options to treat the waste are studied. Therefore, the High-Level Waste Program has funded a program to develop new flowsheets to increase the liquid waste processing rate. Simultaneously, a radionuclide separation process, as well as other options, are also being developed, which will be compared to the calcination treatment option. Two alternatives emerged as viable candidates; (1) elevated temperature calcination (also referred to as high temperature calcination), and (2) sugar-additive calcination. Both alternatives were determined to be viable through testing performed in a lab-scale calcination mockup. Subsequently, 10-cm Calciner Pilot Plant scoping tests were successfully completed for both flowsheets. The results were compared to the standard 500 C, high-ANN flow sheet (baseline flowsheet). The product and effluent streams were characterized to help elucidate the process chemistry and to investigate potential environmental permitting issues. Several supplementary tests were conducted to gain a better understanding of fine-particles generation, calcine hydration, scrub foaming, feed makeup procedures, sugar/organic elimination, and safety-related issues. Many of the experiments are only considered to be scoping tests, and follow-up experiments will be required to establish a more definitive understanding of the flowsheets. However, the combined results support the general conclusion that flowsheet improvements for the NWCF are technically viable.

  7. Play vs. Procedures

    DEFF Research Database (Denmark)

    Hammar, Emil

    Through the theories of play by Gadamer (2004) and Henricks (2006), I will show how the relationship between play and game can be understood as dialectic and disruptive, thus challenging understandings of how the procedures of games determine player activity and vice versa. As such, I posit some...... analytical consequences for understandings of digital games as procedurally fixed (Boghost, 2006; Flannagan, 2009; Bathwaite & Sharp, 2010). That is, if digital games are argued to be procedurally fixed and if play is an appropriative and dialectic activity, then it could be argued that the latter affects...

  8. Natural rates of teacher approval and disapproval in the classroom. (United States)

    White, M A


    Sixteen classroom observational studies were conducted to determine natural rates of teacher verbal approval and disapproval in the classroom. Rates of teacher verbal approval and disapproval were measured by the Teacher Approval and Disapproval Observation Record (TAD) over Grades 1 through 12. Teacher verbal approval rates dropped over grade, with a marked drop after second grade. In every grade after second, the rate of teacher verbal disapproval exceeded the rate of teacher verbal approval. These rates are interpreted in terms of reinforcement theory.

  9. NZ-GMP Approved Serum Improve hDPSC Osteogenic Commitment and Increase Angiogenic Factor Expression (United States)

    Spina, Anna; Montella, Roberta; Liccardo, Davide; De Rosa, Alfredo; Laino, Luigi; Mitsiadis, Thimios A.; La Noce, Marcella


    Human dental pulp stem cells (hDPSCs), selected from the stromal-vascular fraction of dental pulp, are ecto-mesenchymal stem cells deriving from neural crests, successfully used in human bone tissue engineering. For their use in human therapy GMP procedures are required. For instance, the use of fetal bovine serum (FBS) is strongly discouraged in clinical practice due to its high risk of prions and other infections for human health. Alternatively, clinical grade sera have been suggested, including the New Zealand FBS (NZ-FBS). Therefore, the aim of this study was to evaluate the behavior of hDPSCs expanded in culture medium containing NZ-FBS. Since it was widely demonstrated hDPSCs display relevant capabilities to differentiate into osteogenic and angiogenic lineages, we performed a comparative study to assess if these features are also retained by cultivating the cells with a safer serum never tested on this cell line. hDPSCs were grown using NZ-FBS and conventional (C-FBS) for 7, 14, and 21 days, in both 2D and 3D cultures. Growth curves, expression of bone-related markers, calcification and angiogenesis were evaluated. NZ-FBS induced significant cell growth with respect to C-FBS and promoted an earlier increase expression of osteogenic markers, in particular of those involved in the formation of mineralized matrix (BSP and OPN) within 14 days. In addition, hDPSCs cultured in presence of NZ-FBS were found to produce higher mRNA levels of the angiogenic factors, such as VEGF and PDGFA. Taken together, our results highlight that hDPSCs proliferate, enhance their osteogenic commitment and increase angiogenic factors in NZ-FBS containing medium. These features have also been found when hDPSC were seeded on the clinical-grade collagen I scaffold (Bio-Gide®), leading to the conclusion that for human therapy some procedures and above all the use of GMP-approved materials have no negative impact. PMID:27594842

  10. A structural bridge between alternant and non-alternant hydrocarbons

    Directory of Open Access Journals (Sweden)

    Richard Francis Langler


    Full Text Available A simple set of trimethylene-substituted even, fully-pi-bonded, non-alternant monocycles is shown to have several key features in common with acyclic, even alternant polyenes at the Hückel level. These non-alternant molecules provide a bridge between alternant and non-alternant hydrocarbons. This topic might serve as a useful addition to Hückel theory courses targeted at senior undergraduate students.

  11. Short Nuss bar procedure (United States)


    The Nuss procedure is now the preferred operation for surgical correction of pectus excavatum (PE). It is a minimally invasive technique, whereby one to three curved metal bars are inserted behind the sternum in order to push it into a normal position. The bars are left in situ for three years and then removed. This procedure significantly improves quality of life and, in most cases, also improves cardiac performance. Previously, the modified Ravitch procedure was used with resection of cartilage and the use of posterior support. This article details the new modified Nuss procedure, which requires the use of shorter bars than specified by the original technique. This technique facilitates the operation as the bar may be guided manually through the chest wall and no additional stabilizing sutures are necessary. PMID:27747185

  12. Hemodialysis access procedures (United States)

    ... this page: // Hemodialysis access procedures To use the sharing features on ... An access is needed for you to get hemodialysis. The access is where you receive hemodialysis . Using ...

  13. Canalith Repositioning Procedure (United States)

    ... repositioning procedure can help relieve benign paroxysmal positional vertigo (BPPV), a condition in which you have brief, ... dizziness that occur when you move your head. Vertigo usually comes from a problem with the part ...

  14. Cosmetic Procedure Questions (United States)

    ... does it cost? As a rule, almost all cosmetic surgery is considered “elective” and is not typically covered ... premier specialty group representing dermatologists performing all procedures – cosmetic, general, ... Reserved. / Disclaimer / Terms of Use / ...

  15. Procedures for Sampling Vegetation (United States)

    US Fish and Wildlife Service, Department of the Interior — This report outlines vegetation sampling procedures used on various refuges in Region 3. The importance of sampling the response of marsh vegetation to management...

  16. Alternative propulsion for automobiles

    CERN Document Server

    Stan, Cornel


    The book presents – based on the most recent research and development results worldwide - the perspectives of new propulsion concepts such as electric cars with batteries and fuel cells, and furthermore plug in hybrids with conventional and alternative fuels. The propulsion concepts are evaluated based on specific power, torque characteristic, acceleration behaviour, specific fuel consumption and pollutant emissions. The alternative fuels are discussed in terms of availability, production, technical complexity of the storage on board, costs, safety and infrastructure. The book presents summarized data about vehicles with electric and hybrid propulsion. The propulsion of future cars will be marked by diversity – from compact electric city cars and range extender vehicles for suburban and rural areas up to hybrid or plug in SUV´s, Pick up´s and luxury class automobiles.

  17. Adaptive Alternating Minimization Algorithms

    CERN Document Server

    Niesen, Urs; Wornell, Gregory


    The classical alternating minimization (or projection) algorithm has been successful in the context of solving optimization problems over two variables or equivalently of finding a point in the intersection of two sets. The iterative nature and simplicity of the algorithm has led to its application to many areas such as signal processing, information theory, control, and finance. A general set of sufficient conditions for the convergence and correctness of the algorithm is quite well-known when the underlying problem parameters are fixed. In many practical situations, however, the underlying problem parameters are changing over time, and the use of an adaptive algorithm is more appropriate. In this paper, we study such an adaptive version of the alternating minimization algorithm. As a main result of this paper, we provide a general set of sufficient conditions for the convergence and correctness of the adaptive algorithm. Perhaps surprisingly, these conditions seem to be the minimal ones one would expect in ...

  18. [Alternatives to animal testing]. (United States)

    Fabre, Isabelle


    The use of alternative methods to animal testing are an integral part of the 3Rs concept (refine, reduce, replace) defined by Russel & Burch in 1959. These approaches include in silico methods (databases and computer models), in vitro physicochemical analysis, biological methods using bacteria or isolated cells, reconstructed enzyme systems, and reconstructed tissues. Emerging "omic" methods used in integrated approaches further help to reduce animal use, while stem cells offer promising approaches to toxicologic and pathophysiologic studies, along with organotypic cultures and bio-artificial organs. Only a few alternative methods can so far be used in stand-alone tests as substitutes for animal testing. The best way to use these methods is to integrate them in tiered testing strategies (ITS), in which animals are only used as a last resort.

  19. Alternative nanostructures for thermophones (United States)

    Mayo, Nathanael; Aliev, Ali; Baughman, Ray


    There is a large promise for thermophones in high power sonar arrays, flexible loudspeakers, and noise cancellation devices. So far, freestanding aerogel-like carbon nanotube sheets demonstrate the best performance as a thermoacoustic heat source. However, the limited accessibility of large size freestanding carbon nanotube sheets and other even more exotic materials published recently, hampers the field. We present here new alternative materials for a thermoacoustic heat source with high energy conversion efficiency, additional functionalities, environmentally friendly and cost effective production technologies. We discuss the thermoacoustic performance of alternative nanoscale materials and compare their spectral and power dependencies of sound pressure in air. The study presented here focuses on engineering thermal gradients in the vicinity of nanostructures and subsequent heat dissipation processes from the interior of encapsulated thermoacoustic projectors. Applications of thermoacoustic projectors for high power SONAR arrays, sound cancellation, and optimal thermal design, regarding enhanced energy conversion efficiency, are discussed.

  20. 7 CFR 58.149 - Alternate quality control programs for dairy products. (United States)


    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Alternate quality control programs for dairy products... FOR GRADES OF DAIRY PRODUCTS 1 General Specifications for Dairy Plants Approved for USDA Inspection... for dairy products. (a) When a plant has in operation an acceptable quality control program which...

  1. Report to the Congress on alternative methods for the Strategic Petroleum Reserve

    Energy Technology Data Exchange (ETDEWEB)


    The purpose of this study is to fulfill the requirements of Public Law No. 101-46, approved June 30, 1989. The study describes and evaluates alternative methods for financing the future expansion of the Strategic petroleum Reserve (SPR), both to the current target level of 750 million barrels and to potential future levels of up to one billion barrels.

  2. A Study on Becoming an Alternatively Certified Career and Technical Educator (United States)

    Cotton-Flanagan, Kymberli A.


    This mixed method study examined the perspectives of twelve practicing high school CTE teachers engaged in a newly approved university model for alternative certification. Using Creswell's (2008) Sequential Exploratory Design and the lens of adult learning theory as established in Knowles' (1970) Theory of Andragogy, this study examines how…

  3. Metamaterials critique and alternatives

    CERN Document Server

    Munk, Ben A


    A Convincing and Controversial Alternative Explanation of Metamaterials with a Negative Index of Refraction In a book that will generate both support and controversy, one of the world's foremost authorities on periodic structures addresses several of the current fashions in antenna design-most specifically, the popular subject of double negative metamaterials. Professor Munk provides a comprehensive theoretical electromagnetic investigation of the issues and concludes that many of the phenomena claimed by researchers may be impossible. While denying the existence of negative refractio

  4. Weighted overlap dominance – a procedure for interactive selection on multidimensional interval data

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Nielsen, Kurt


    We present an outranking procedure that supports selection of alternatives represented by multiple attributes with interval valued data. The procedure is interactive in the sense that the decision maker directs the search for preferred alternatives by providing weights of the different attributes...... as well as parameters related to risk attitude and weighted dominance. The outranking relation builds on pairwise comparisons between optimistic and pessimistic weighted values as well as weighted dominance relations supported by volume based measures. The suggested procedure is referred...

  5. Outlook for alternative transportation fuels

    Energy Technology Data Exchange (ETDEWEB)

    Gushee, D.E. [Univ. of Illinois, Chicago, IL (United States)


    This presentation provides a brief review of regulatory issues and Federal programs regarding alternative fuel use in automobiles. A number of U.S. DOE initiatives and studies aimed at increasing alternative fuels are outlined, and tax incentives in effect at the state and Federal levels are discussed. Data on alternative fuel consumption and alternative fuel vehicle use are also presented. Despite mandates, tax incentives, and programs, it is concluded alternative fuels will have minimal market penetration. 7 refs., 5 tabs.

  6. Alternative Fuels: Research Progress

    Directory of Open Access Journals (Sweden)

    Maher A.R. Sadiq Al-Baghdadi


    Full Text Available Chapter 1: Pollutant Emissions and Combustion Characteristics of Biofuels and Biofuel/Diesel Blends in Laminar and Turbulent Gas Jet Flames. R. N. Parthasarathy, S. R. Gollahalli Chapter 2: Sustainable Routes for The Production of Oxygenated High-Energy Density Biofuels from Lignocellulosic Biomass. Juan A. Melero, Jose Iglesias, Gabriel Morales, Marta Paniagua Chapter 3: Optical Investigations of Alternative-Fuel Combustion in an HSDI Diesel Engine. T. Huelser, M. Jakob, G. Gruenefeld, P. Adomeit, S. Pischinger Chapter 4: An Insight into Biodiesel Physico-Chemical Properties and Exhaust Emissions Based on Statistical Elaboration of Experimental Data. Evangelos G. Giakoumis Chapter 5: Biodiesel: A Promising Alternative Energy Resource. A.E. Atabani Chapter 6: Alternative Fuels for Internal Combustion Engines: An Overview of the Current Research. Ahmed A. Taha, Tarek M. Abdel-Salam, Madhu Vellakal Chapter 7: Investigating the Hydrogen-Natural Gas Blends as a Fuel in Internal Combustion Engine. ?lker YILMAZ Chapter 8: Conversion of Bus Diesel Engine into LPG Gaseous Engine; Method and Experiments Validation. M. A. Jemni , G. Kantchev , Z. Driss , R. Saaidia , M. S. Abid Chapter 9: Predicting the Combustion Performance of Different Vegetable Oils-Derived Biodiesel Fuels. Qing Shu, ChangLin Yu Chapter 10: Production of Gasoline, Naphtha, Kerosene, Diesel, and Fuel Oil Range Fuels from Polypropylene and Polystyrene Waste Plastics Mixture by Two-Stage Catalytic Degradation using ZnO. Moinuddin Sarker, Mohammad Mamunor Rashid

  7. Alternative Energy Sources

    CERN Document Server

    Michaelides, Efstathios E (Stathis)


    Alternative Energy Sources is designed to give the reader, a clear view of the role each form of alternative energy may play in supplying the energy needs of the human society in the near and intermediate future (20-50 years).   The two first chapters on energy demand and supply and environmental effects, set the tone as to why the widespread use of alternative energy is essential for the future of human society. The third chapter exposes the reader to the laws of energy conversion processes, as well as the limitations of converting one energy form to another. The sections on exergy give a succinct, quantitative background on the capability/potential of each energy source to produce power on a global scale. The fourth, fifth and sixth chapters are expositions of fission and fusion nuclear energy. The following five chapters (seventh to eleventh) include detailed descriptions of the most common renewable energy sources – wind, solar, geothermal, biomass, hydroelectric – and some of the less common sources...

  8. Alternative Multiview Maximum Entropy Discrimination. (United States)

    Chao, Guoqing; Sun, Shiliang


    Maximum entropy discrimination (MED) is a general framework for discriminative estimation based on maximum entropy and maximum margin principles, and can produce hard-margin support vector machines under some assumptions. Recently, the multiview version of MED multiview MED (MVMED) was proposed. In this paper, we try to explore a more natural MVMED framework by assuming two separate distributions p1( Θ1) over the first-view classifier parameter Θ1 and p2( Θ2) over the second-view classifier parameter Θ2 . We name the new MVMED framework as alternative MVMED (AMVMED), which enforces the posteriors of two view margins to be equal. The proposed AMVMED is more flexible than the existing MVMED, because compared with MVMED, which optimizes one relative entropy, AMVMED assigns one relative entropy term to each of the two views, thus incorporating a tradeoff between the two views. We give the detailed solving procedure, which can be divided into two steps. The first step is solving our optimization problem without considering the equal margin posteriors from two views, and then, in the second step, we consider the equal posteriors. Experimental results on multiple real-world data sets verify the effectiveness of the AMVMED, and comparisons with MVMED are also reported.

  9. 75 FR 6597 - Determination to Approve Alternative Final Cover Request for the Lake County, MT Landfill... (United States)


    ... and constructed to: (1) Have a permeability less than or equal to the permeability of any bottom liner system or natural sub-soils present, or a permeability no greater than 1x10 -5 cm/sec, whichever is less... final cover. EPA is basing its determination on a number of factors, including unsaturated soil...

  10. 75 FR 20925 - Petition for Approval of Alternate Odometer Disclosure Requirements (United States)


    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION...: Andrew DiMarsico, Office of the Chief Counsel, National Highway Traffic Safety Administration, 1200 New... Texas Department of Transportation proposes a paperless electronic title transfer scheme, described...

  11. 77 FR 50071 - Petition for Approval of Alternate Odometer Disclosure Requirements (United States)


    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION...: Kerry Kolodziej, Office of the Chief Counsel, National Highway Traffic Safety Administration, 1200 New... petition describes Arizona as having state laws designed to facilitate a nearly paperless vehicle...

  12. 76 FR 65485 - Petition for Approval of Alternate Odometer Disclosure Requirements (United States)


    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION.... FOR FURTHER INFORMATION CONTACT: Otto G. Matheke, III, Office of the Chief Counsel, National Highway... (``NYSDMV'') proposes a paperless odometer disclosure program for transfers to, between and from...

  13. 75 FR 20965 - Petition for Approval of Alternate Odometer Disclosure Requirements (United States)


    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION... accessing the dockets. FOR FURTHER INFORMATION CONTACT: Andrew DiMarsico, Office of the Chief Counsel... disclosure requirements. The Wisconsin Department of Transportation proposes a paperless odometer...

  14. 76 FR 1367 - Petition for Approval of Alternate Odometer Disclosure Requirements (United States)


    ... is processed by DMV agent or financial institution; 9. Lessee to lessor statement upon relinquishing... financial institution) or an intermittent user. For a DMV partner or regular customer, the first step is... user to access the appropriate information. In addition to the identification protocols, vendors...

  15. High Falls generation station expansion approvals process

    Energy Technology Data Exchange (ETDEWEB)

    Litschko, C. [Lakeland Holding, Bracebridge, ON (Canada)


    Lakeland Holding Ltd. is the parent company for Lakeland Power Distribution Ltd., Bracebridge Generation Ltd., and Lakeland Energy Ltd. This PowerPoint presentation highlighted the High Falls generation expansion process. During construction of the High Falls plant, a concrete foundation was built beside the plant for future expansion. The expansion process involves building a 1,500 kilowatt generator to supply electricity to as many as 1600 households. The presentation described the context and background for the expansion and presented information on the water power generation plants. It presented site specifications as well as the approvals process by which final approval was granted in 2004. Observations and lessons learned from the approval process were identified. figs.

  16. Automation of procedure writing for the RLWTF

    Energy Technology Data Exchange (ETDEWEB)

    Farnham, M. [Mega International USA, Inc. (United States)]|[Los Alamos National Lab., NM (United States); MacDonald, A. [IT Corp. (United States)]|[Los Alamos National Lab., NM (United States)


    In August of 1997, the Radioactive Liquid Waste Treatment Facility (RLWTF) at Los Alamos National Laboratory (LANL) recognized the need to re-engineer document management business process. All nuclear facilities at LANL are required to ensure that both the latest approved revision of controlled documents and any changes to those documents are available to operating personnel at all times. The Nuclear Materials Technology (NMT) Division was also re-engineering its document management business processes and searching for a solution. Both groups contacted several internal and external organizations in search of potential software solutions in use that would meet requirements. This report describes the objectives and features required by the software package, the choice of Procedure Design as the software package, and its implementation.

  17. Alternative Refrigerant Evaluation for High-Ambient-Temperature Environments: R-22 and R-410A Alternatives for Rooftop Air Conditioners

    Energy Technology Data Exchange (ETDEWEB)

    Abdelaziz, Omar [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shrestha, Som S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shen, Bo [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Linkous, Randall Lee [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Goetzler, William [Navigant Consulting Inc., Burlington, MA (United States); Guernsey, Matt [Navigant Consulting Inc., Burlington, MA (United States); Bargach, Youssef [Navigant Consulting Inc., Burlington, MA (United States)


    The Oak Ridge National Laboratory (ORNL) High-Ambient-Temperature Evaluation Program for Low-Global Warming Potential (Low-GWP) Refrigerants aims to develop an understanding of the performance of low-GWP alternative refrigerants relative to hydrochlorofluorocarbon (HCFC) and hydrofluorocarbon (HFC) refrigerants in packaged or Rooftop Unit (RTU) air conditioners under high-ambient-temperature conditions. This final report describes the parties involved, the alternative refrigerants selection process, the test procedures, and the final results.

  18. Estimation of the Number of Children with Limited English Proficiency: A Review of Analytic Procedures. (United States)

    Peng, Samuel S.; And Others


    Two major analytic procedures for estimating the number of children with limited English proficiency (discriminant analysis and probabilistic procedures) are described and strengths and weaknesses discussed. Synthetic cohort analysis (an expanded version of the probabilistic approach) is described and recommended as an alternate procedure for…

  19. Mobile Energy Laboratory Procedures

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, P.R.; Batishko, C.R.; Dittmer, A.L.; Hadley, D.L.; Stoops, J.L.


    Pacific Northwest Laboratory (PNL) has been tasked to plan and implement a framework for measuring and analyzing the efficiency of on-site energy conversion, distribution, and end-use application on federal facilities as part of its overall technical support to the US Department of Energy (DOE) Federal Energy Management Program (FEMP). The Mobile Energy Laboratory (MEL) Procedures establish guidelines for specific activities performed by PNL staff. PNL provided sophisticated energy monitoring, auditing, and analysis equipment for on-site evaluation of energy use efficiency. Specially trained engineers and technicians were provided to conduct tests in a safe and efficient manner with the assistance of host facility staff and contractors. Reports were produced to describe test procedures, results, and suggested courses of action. These reports may be used to justify changes in operating procedures, maintenance efforts, system designs, or energy-using equipment. The MEL capabilities can subsequently be used to assess the results of energy conservation projects. These procedures recognize the need for centralized NM administration, test procedure development, operator training, and technical oversight. This need is evidenced by increasing requests fbr MEL use and the economies available by having trained, full-time MEL operators and near continuous MEL operation. DOE will assign new equipment and upgrade existing equipment as new capabilities are developed. The equipment and trained technicians will be made available to federal agencies that provide funding for the direct costs associated with MEL use.

  20. Re-examination of regulatory opinions in Europe: possible contribution for the approval of the first gene therapy product Glybera (United States)

    Watanabe, Natsumi; Yano, Kazuo; Tsuyuki, Kenichiro; Okano, Teruo; Yamato, Masayuki


    The first commercially approved human gene therapy in the Western world is Glybera (alipogene tiparvovec), which is an adenoassociated viral vector encoding the lipoprotein lipase gene. Glybera was recommended for marketing authorization by the European Medicines Agency in 2012. The European Medicines Agency had only ever reviewed three marketing authorization applications for gene therapy medicinal products. Unlike in the case of Glybera, the applications of the first two products, Cerepro and Contusugene Ladenovec Gendux/Advexin, both of which were for cancer diseases, were withdrawn. In this report, we studied the European public assessment reports of the three gene therapy products. During the assessment process, Glybera was re-examined and reviewed for a fourth time. We therefore researched the re-examination procedure of the European Union regulatory process. Approximately 25% of the new medicinal products initially given negative opinions from the Committee for Medicinal Products for Human Use were ultimately approved after re-examination from 2009 to 2013. The indications of most medicines were changed during the re-examination procedure, and the products were later approved with a mode of approval. These results suggested that the re-examination system in the European Union contributed to the approval of both several new drugs and the first gene therapy product. PMID:26052534

  1. Unproven diagnostic procedures in IgE-mediated allergic diseases. (United States)

    Niggemann, B; Grüber, C


    A considerable body of literature on therapeutic aspects of complementary and alternative medicine has been published in recent years, but little is known on diagnostic procedures. This short review lists complementary and alternative diagnostic procedures for the diagnosis of allergic diseases and presents an assessment of their usefulness for the daily practice. The review of the literature revealed that neither the determination of specific immunoglobulin G-antibodies in serum, the hair-analysis, the cytotoxic test, kinesiology, iridology, or electrodermal testing represent useful tests for the daily practice. To date, no complementary or alternative diagnostic procedure can be recommended as a meaningful element in the diagnostic work-up of allergic diseases. This is especially true for food allergy: properly performed oral food challenges still represent the gold standard for implementing specific diets in food allergic individuals. Ineffective diagnostic approaches may be costly for the consumer and delay appropriate therapy.

  2. Alternatives to animal testing: A review. (United States)

    Doke, Sonali K; Dhawale, Shashikant C


    The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern of ethics, there are few more disadvantages of animal experimentation like requirement of skilled manpower, time consuming protocols and high cost. Various alternatives to animal testing were proposed to overcome the drawbacks associated with animal experiments and avoid the unethical procedures. A strategy of 3 Rs (i.e. reduction, refinement and replacement) is being applied for laboratory use of animals. Different methods and alternative organisms are applied to implement this strategy. These methods provide an alternative means for the drug and chemical testing, up to some levels. A brief account of these alternatives and advantages associated is discussed in this review with examples. An integrated application of these approaches would give an insight into minimum use of animals in scientific experiments.

  3. An alternative parameterization of R-matrix theory

    Energy Technology Data Exchange (ETDEWEB)

    Brune, C.R


    An alternative parameterization of R-matrix theory is described which is mathematically equivalent to the standard approach, but which has no level shifts. The positions and partial widths of an arbitrary number of levels can thus be easily fixed in an analysis. These alternative parameters can be converted to standard R-matrix parameters by a straightforward matrix diagonalization procedure, and a 'level matrix' formulation is possible which allows the collision matrix to be expressed directly in terms of the alternative parameters. The applications to radiative capture reactions and {beta}-delayed particle spectra are briefly discussed.

  4. Assessing the potential clinical impact of reciprocal drug approval legislation on access to novel therapeutics in the USA: a cohort study (United States)

    Larochelle, Matthieu; Downing, Nicholas S; Ross, Joseph S; David, Frank S


    Objective To quantify the potential effect of reciprocal approval legislation on access to clinically impactful therapeutics in the USA. Design A cohort study. Setting New therapeutics approved by the Food and Drug Administration (FDA), European Medicines Agency (EMA) and/or Health Canada between 2000 and 2010. Main outcome measures Characteristics of new therapeutics approved by the EMA and/or Health Canada before the FDA, including mechanistic novelty, likely clinical impact, size of the affected population and FDA review outcome. Results From 2001 to 2010, 282 drugs were approved in the USA, Europe or Canada, including 172 (61%) first approved in the USA, 24 (9%) never approved in the USA, and 86 (30%) approved in the USA after Europe and/or Canada. Of the 110 new drugs approved in Europe and/or Canada before the USA, 37 (34%) had a novel mechanisms of action compared with drugs already approved by the FDA, but only 10 (9%) were for conditions lacking alternate available therapies in the USA at the time of ex-US approval—of which the majority (9/10; 90%) were indicated for rare diseases. 12 of the 37 agents with novel mechanisms of action approved first in Europe and/or Canada (32%) had their initial FDA submissions rejected for safety reasons—including 2 drugs that were ultimately withdrawn from the market in Europe due to safety concerns. Conclusions If enacted, reciprocal approval legislation would most likely benefit only a small number of US patients receiving treatment for rare diseases, and the benefit may be somewhat mitigated by an increased exposure to harms. PMID:28179418

  5. Alternative to Nitric Acid Passivation Project Overview (United States)

    Lewis, Pattie L.


    The standard practice for protection of stainless steel is a process called passivation. This procedure results in the formation of a metal oxide layer to prevent corrosion. Typical passivation procedures call for the use of nitric acid which exhibits excellent corrosion performance; however, there are a number of environmental, worker safety, and operational issues associated with its use. The longtime military specification for the passivation of stainless steel was cancelled in favor of newer specifications which allow for the use of citric acid in place of nitric acid. Citric acid offers a variety of benefits that include increased safety for personnel, reduced environmental impact, and reduced operational costs. There have been few studies, however, to determine whether citric acid is an acceptable alternative for NASA and DoD. This paper details activities to date including development of the joint test plan, on-going and planned testing, and preliminary results.

  6. Alternative methodology for Scott-Knott test

    Directory of Open Access Journals (Sweden)

    Leonardo Lopes Bhering


    Full Text Available The test proposed by Scott Knott (1974, a procedure of means grouping, is an effective alternative to performprocedures of multiple comparisons without ambiguity. This study aimed to propose a modification related to the partitioningand means grouping in the said procedure, to obtain results without ambiguity among treatments, organized in morehomogeneous groups. In the proposed methodology, treatments that did not participate in the initial group are joined for a newanalysis, which allows for a better group distribution. In a comparative study, four experiments were simulated in a randomizedcomplete block design. The first consisted of 10 and the other 3 of 100 treatments. All experiments were performed in threereplications at a significance level of 0.05 for the means grouping test. Only in the third experiment of those of 100 treatmentsthe groups formed by Scott-Knott did not differ from the methodology proposed here. The proposed methodology is consideredeffective, aiming at the identification of elite cultivar groups for recommendation.

  7. Alternate fuels; Combustibles alternos

    Energy Technology Data Exchange (ETDEWEB)

    Romero Paredes R, Hernando; Ambriz G, Juan Jose [Universidad Autonoma Metropolitana. Iztapalapa (Mexico)


    In the definition and description of alternate fuels we must center ourselves in those technological alternatives that allow to obtain compounds that differ from the traditional ones, in their forms to be obtained. In this article it is tried to give an overview of alternate fuels to the conventional derivatives of petroleum and that allow to have a clear idea on the tendencies of modern investigation and the technological developments that can be implemented in the short term. It is not pretended to include all the tendencies and developments of the present world, but those that can hit in a relatively short term, in accordance with agreed with the average life of conventional fuels. Nevertheless, most of the conversion principles are applicable to the spectrum of carbonaceous or cellulosic materials which are in nature, are cultivated or wastes of organic origin. Thus one will approach them in a successive way, the physical, chemical and biological conversions that can take place in a production process of an alternate fuel or the same direct use of the fuel such as burning the sweepings derived from the forests. [Spanish] En la definicion y descripcion de combustibles alternos nos debemos centrar en aquellas alternativas tecnologicas que permitan obtener compuestos que difieren de los tradicionales, al menos en sus formas de ser obtenidos. En este articulo se pretende dar un panorama de los combustibles alternos a los convencionales derivados del petroleo y que permita tener una idea clara sobre las tendencias de la investigacion moderna y los desarrollos tecnologicos que puedan ser implementados en el corto plazo. No se pretende abarcar todas las tendencias y desarrollos del mundo actual, sino aquellas que pueden impactar en un plazo relativamente corto, acordes con la vida media de los combustibles convencionales. Sin embargo, la mayor parte de los principios de conversion son aplicables al espectro de materiales carbonaceos o celulosicos los cuales se

  8. Arianespace streamlines launch procedures (United States)

    Lenorovitch, Jeffrey M.


    Ariane has entered a new operational phase in which launch procedures have been enhanced to reduce the length of launch campaigns, lower mission costs, and increase operational availability/flexibility of the three-stage vehicle. The V50 mission utilized the first vehicle from a 50-launcher production lot ordered by Arianespace, and was the initial flight with a stretched third stage that enhances Ariane's performance. New operational procedures were introduced gradually over more than a year, starting with the V42 launch in January 1991.

  9. Procedure and Program Examples (United States)

    Britz, Dieter

    Here some modules, procedures and whole programs are described, that may be useful to the reader, as they have been, to the author. They are all in Fortran 90/95 and start with a generally useful module, that will be used in most procedures and programs in the examples, and another module useful for programs using a Rosenbrock variant. The source texts (except for the two modules) are not reproduced here, but can be downloaded from the web site &issn=1616-6361&volume=666 (the two lines form one contiguous URL!).

  10. 42 CFR 422.158 - Procedures for approval of accreditation as a basis for deeming compliance. (United States)


    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Quality... the accreditation organization, including— (i) The size and composition of accreditation survey teams... teams; and (v) The organization's policies and practice with respect to the participation, in surveys...

  11. 14 CFR 303.04 - General rules governing application content, procedure and conditions of approval. (United States)


    ... applicants shall file an affidavit executed by the individual responsible for the search explaining why they... is filed with the Documentary Services Division. (j) The applicant shall, if requested,...

  12. 78 FR 24347 - Approval and Promulgation of Implementation Plans; Oregon: Open Burning and Enforcement Procedures (United States)


    ... discretionary authority to address, as appropriate, disproportionate human health or environmental effects... Environmental protection, Air pollution control, Incorporation by reference, Intergovernmental relations... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL...

  13. 78 FR 66648 - Approval and Promulgation of Implementation Plans; Texas; Procedures for Stringency... (United States)


    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION... proposal because EPA anticipated no adverse comments. EPA stated in the direct final rule that if we received relevant, adverse comments by October 10, 2013, EPA would publish a timely withdrawal in...

  14. 78 FR 55221 - Approval and Promulgation of Implementation Plans; Texas; Procedures for Stringency... (United States)


    ... disclosure. The Web site is an ``anonymous access'' system, which means that EPA... make the appointment at least two working days in advance of your visit. A 15 cent per page fee will be... program into the SIP is appropriate and necessary to ensure proper functionality for both the Title I...

  15. 46 CFR 160.035-14 - Procedure for approval of lifeboats. (United States)


    ..., plans covering fully the arrangement and construction of the lifeboat, material specifications, together with a lines drawing, stowage arrangement, seating arrangement, and other details shall be submitted to... conditions or circumstances which may arise during the construction or testing. (c) At the time that...

  16. 46 CFR 160.032-6 - Procedure for approval of davits. (United States)


    ... fully the arrangement and construction of the davit together with stress diagrams and calculations... required by § 160.032-5. (c) At the time that the tests are successfully completed, the manufacturer shall... submitted at that time. (d) Upon receipt of corrected drawings and satisfactory test report, the...

  17. 46 CFR 160.015-6 - Procedure for approval of lifeboat winches. (United States)


    ... of lifeboat winch, detail plans covering fully the arrangement and construction of the lifeboat winch..., conduct the tests required by § 160.015-5. (c) At the time that the tests are successfully completed, the... shall be submitted at that time. (d) Upon receipt of corrected drawings, material affidavits,...

  18. 76 FR 59421 - Proposed Information Collection; Approval Procedures for Nontoxic Shot and Shot Coatings (United States)


    ... hunting of migratory game birds through regulations in 50 CFR part 20. On January 1, 1991, we banned lead...-2482 (telephone). SUPPLEMENTARY INFORMATION: I. Abstract The Migratory Bird Treaty Act (MBTA) (16 U.S.C. 703 et seq.) prohibits the unauthorized take of migratory birds and authorizes the Secretary of...

  19. 48 CFR 3009.171-7 - Contract award approval procedures for contractors with felony convictions. (United States)


    ... felony no longer calls into question the individual or business concern's integrity or business ethics... individual or business concern's integrity or business ethics and that an award would be consistent with the... request to permit award of a contract for FPS guard services to a business concern owned, controlled,...

  20. 78 FR 16159 - Application Procedures and Criteria for Approval of Providers of a Personal Financial Management... (United States)


    ... restrictive of commercial speech than is necessary to advance the government's interest in consumer protection... commercial speech. See, e.g., Central Hudson Gas & Elec. Corp. v. Public Serv. Comm'n, 447 U.S. 557 (1980) (holding that restrictions on commercial speech must directly advance an important interest and shall be...

  1. 78 FR 16138 - Application Procedures and Criteria for Approval of Nonprofit Budget and Credit Counseling... (United States)


    ... in quality immediately. Finally, advertising constitutes commercial speech and is subject to... advertising is protected speech and the quoted phrase raises doubts in the mind of the consumer concerning the... Commercial Advertising and Sale of Personal Information Comment: One comment stated the protections in...

  2. The Ethics and Politics of Ethics Approval (United States)

    Battin, Tim; Riley, Dan; Avery, Alan


    The regulatory scope of Human Research Ethics Committees can be problematic for a variety of reasons. Some scholars have argued the ethics approval process, for example, is antithetical to certain disciplines in the humanities and social sciences, while others are willing to give it qualified support. This article uses a case study to cast the…

  3. 40 CFR 52.2522 - Approval status. (United States)


    ... provisions do not meet the requirements of 40 CFR 51.160 for scope. EPA also disapproves 45 CSR 13 section 9... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Approval status. 52.2522 Section 52.2522 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  4. Approved Practices in Dairy Reproduction. Slide Script. (United States)

    Roediger, Roger D.; Barr, Harry L.

    This slide script, part of a series of slide scripts designed for use in vocational agriculture classes, deals with approved practices in dairy reproduction. Included in the guide are narrations for use with 200 slides dealing with the following topics: the importance of good reproduction, the male and female roles in reproduction, selection of…

  5. 42 CFR 422.2266 - Deemed approval. (United States)


    ... 42 Public Health 3 2010-10-01 2010-10-01 false Deemed approval. 422.2266 Section 422.2266 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2266...

  6. 42 CFR 423.2266 - Deemed approval. (United States)


    ... 42 Public Health 3 2010-10-01 2010-10-01 false Deemed approval. 423.2266 Section 423.2266 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Part D Marketing Requirements §...

  7. 7 CFR 322.4 - Approved regions. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Approved regions. 322.4 Section 322.4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...

  8. 7 CFR 1425.4 - Approval. (United States)


    ... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.4 Approval. (a) For a cooperative to gain CMA status to participate in a marketing assistance loan or Loan deficiency... prepared in accordance with generally accepted accounting principles; (3) A copy of the articles...

  9. Perkins Bill is Approved by Congress (United States)

    Cavanagh, Sean


    Career and technical education programs will face new pressure to show that they are academically rigorous and guiding high school students through a lineup of courses that prepares them for college or the workplace, under a bill approved by Congress. The reauthorization of the federal law known as the Perkins Act--dealing with what traditionally…

  10. Program and Course Approval Handbook. Fifth Edition (United States)

    California Community Colleges, Chancellor's Office, 2013


    This "Program and Course Approval Handbook" assists California Community College (CCC) administrators, faculty, and staff in the development of programs and courses and the submission of these proposals for review by the Chancellor's Office. By law, the Chancellor is required to prepare and distribute a handbook for program and course…

  11. 7 CFR 3565.103 - Approval requirements. (United States)


    ... lender must provide the Agency with an annual audited financial statement conducted in accordance with... reserves, to have an acceptable level of financial soundness as determined by a lender rating service (such... AGRICULTURE GUARANTEED RURAL RENTAL HOUSING PROGRAM Lender Requirements § 3565.103 Approval requirements....

  12. Approval of Spouse in Middle Age. (United States)

    Troll, Lillian E.

    A strongly positive opinion of spouse in middle age tends to be associated with social conformity and family integration. Mutually approving couples were more often politically moderate, homogamous in religious background, and had more interpersonal power than their children. They also had more highly integrated family structures with low conflict…

  13. 28 CFR 48.15 - Temporary approval. (United States)


    ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) NEWSPAPER PRESERVATION ACT § 48.15 Temporary... temporary approval may do so by delivering a statement of protest or telephoning his views to an employee of the Department of Justice, whose name, address and telephone number shall be designated by...

  14. Reflections on the Ethics-Approval Process (United States)

    Murray, Lee; Pushor, Debbie; Renihan, Pat


    It is sometimes a difficult journey receiving ethics approval for research involving vulnerable populations, research involving our own children, or innovative research methodologies such as autoethnography. This autoethnographical account is a story about one student who wanted to write a PhD dissertation in a very different way and also the…

  15. 40 CFR 1042.210 - Preliminary approval. (United States)


    ... specific provisions that apply for deterioration factors. Decisions made under this section are considered... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Preliminary approval. 1042.210 Section 1042.210 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION...

  16. 40 CFR 52.373 - Approval status. (United States)


    ... approves the total suspended particulate regulation for foundry sand processes as submitted and identified... the particulate matter and not the requirement to emit not more than 0.75 pounds of particulate per ton of material cast, a provision which may be found in state regulation 19-508-18(f)(3)....

  17. 7 CFR 52.53 - Approved identification. (United States)


    ...) When graded against a U.S. grade standard, meet the quality requirements for U.S Grade C or better; (5) Meet applicable fill weight and/or drained weight, Brix or other characteristics of a commodity related... approved by USDA inspection service prior to use. (b) Inspection (Continuous) grade and inspection...

  18. [Alternative surgical options to heart transplantation]. (United States)

    Dreyfus, G


    Cardiac transplantation is the treatment of reference for refractory cardiac failure but the limited number of donors, the complications inherent to transplantation and the relative and absolute contra-indications has made it necessary to find alternative surgical solutions. The detection of myocardial viability by Thallium scintigraphy, Dobutamine echocardiography and/or position emission tomography in coronary disease, allows identification of zones which are capable of recovering contractile function after revascularisation. The authors report the results of a series of 91 operated patients with a 10 year follow-up having a 72% 5 year actuarial survival and improved ejection fraction. The other alternative which may improve symptoms and prognosis in patients with severe ischaemic heart disease with left ventricular dysfunction is apical remodelling or Dor's procedure. The results of a haemodynamic study at 1 year of 171 patients clearly show a functional improvement and an increase of the ejection fraction. The advantage of this method is that it can be used in patients with dyskinetic and akinetic plaques resulting from antero-septo-apical infarction. Finally, even if mitral regurgitation is relatively uncommon in chronic ischaemic heart disease, a simple procedure (annuloplasty) is often sufficient to correct the mitral regurgitation and reduce the afterload of a failing ventricle. On the other hand, in dilated cardiomyopathy, two new options have been developed; one, suggested by Steven Bolling, proposes simple mitral annuloplasty whatever the underlying cause (primary or ischaemic cardiomyopathy) with symptomatic improvement and better haemodynamics in terms of increased cardiac output and oxygen consumption on exercise and an actuarial survival much higher than that of cardiac transplantation at one and at two years. The most recent innovation is the Batista procedure which is a method of ventricular reduction associated with correction of mitral

  19. Trends in global approvals of biotech crops (1992-2014). (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A


    With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992-2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits.

  20. Alternative Therapies for PKU

    Directory of Open Access Journals (Sweden)

    Norma Spécola MD


    Full Text Available The phenylalanine (PHE-restricted diet has improved in quality and diversity over time and has proven to be effective in all patients. Nevertheless, this treatment imposes a heavy social and economic burden to patient and family and impacts quality of life. Sustained adherence to PHE restriction is difficult to maintain. Moreover, even patients with phenylketonuria (PKU with normal intelligence quotient (IQ have lower IQ than matched individuals without PKU and can have deficits in multiple other aspects of neuropsychological function, including cognitive and executive function, working memory. They can also have behavior problems, depression, and low self-esteem. In recent years, alternative treatments for PKU have been developed and their use has been indicated for some patients who are candidates for options besides traditional treatment. Sapropterindihydrochloride, large neutral amino acids, and glycomacropeptide are alternative treatment options in use for selected patients. The aim of this article is to review the current knowledge of these new approaches to PKU treatment.

  1. Short Nuss bar procedure

    DEFF Research Database (Denmark)

    Pilegaard, Hans Kristian


    The Nuss procedure is now the preferred operation for surgical correction of pectus excavatum (PE). It is a minimally invasive technique, whereby one to three curved metal bars are inserted behind the sternum in order to push it into a normal position. The bars are left in situ for three years...

  2. Straightening out Legal Procedures

    Institute of Scientific and Technical Information of China (English)


    China’s top legislature mulls giving the green light to class action litigations The long-awaited amendment of China’s Civil Procedure Law has taken a crucial step.On October 28,the Standing Committee of the National People’s Congress(NPC),China’s top legislature,reviewed a draft amendment to the law for the first time.

  3. Educational Accounting Procedures. (United States)

    Tidwell, Sam B.

    This chapter of "Principles of School Business Management" reviews the functions, procedures, and reports with which school business officials must be familiar in order to interpret and make decisions regarding the school district's financial position. Among the accounting functions discussed are financial management, internal auditing,…

  4. Anxiety Around Medical Procedures (United States)

    ... understand that these procedures are necessary for fighting cancer, your child may not understand — and it is often hard ... Deaths Per Year 5-Year Survival Rate Childhood Cancer Infographics Webinars Parents Webinars Child Life Specialist Webinars School Personnel Webinars Video Library ...

  5. Alternative Medicine and Your Child (United States)

    ... 1- to 2-Year-Old Complementary and Alternative Medicine KidsHealth > For Parents > Complementary and Alternative Medicine A ... works. previous continue How CAM Differs From Traditional Medicine CAM is frequently distinguished by its holistic methods, ...

  6. A fresh perspective on comparing the FDA and the CHMP/EMA: approval of antineoplastic tyrosine kinase inhibitors. (United States)

    Shah, Rashmi R; Roberts, Samantha A; Shah, Devron R


    We compared and determined the reasons for any differences in the review and approval times of tyrosine kinase inhibitors (TKIs) by the US Food and Drug Administration (FDA) and the European EMA/CHMP. Applications for these novel cancer drugs were submitted to them within a mean of 31.2 days of each other, providing a fair basis for comparison. The FDA had granted priority review to 12 TKIs but the EMA/CHMP did not grant the equivalent accelerated assessment to any. The FDA granted accelerated approvals to six (38%) and CHMP granted (the equivalent) conditional approvals to four (29%) of these agents. On average, the review and approval times were 205.3 days in the US compared with 409.6 days in the European Union (EU). The active review times, however, were comparable (225.4 days in the EU and 205.3 days in the US). Since oncology drug development lasts about 7 years, the 20 days difference in review times between the two agencies is inconsequential. Clock stops during review and the time required to issue an approval had added the extra 184.2 days to review time in the EU. We suggest possible solutions to expedite the EU review and approval processes. However, post-marketing emergence of adverse efficacy and safety data on gefitinib and lapatinib, respectively, indicate potential risks of expedited approvals. We challenge the widely prevalent myth that early approval translates into early access or beneficial impact on public health. Both the agencies collaborate closely but conduct independent assessments and make decisions based on distinct legislation, procedures, precedents and societal expectations.

  7. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book) (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  8. 46 CFR 162.050-23 - Separator: Approval tests. (United States)


    ...: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-23 Separator: Approval... hour, the separator must be inclined at an angle of 22.5° with the plane of its normal...

  9. FDA Approves New Treatment for Dust Mite Allergies (United States)

    ... page: FDA Approves New Treatment for Dust Mite Allergies Odactra ... life," said Dr. Peter Marks, director of the FDA's Center for Biologics Evaluation and Research. "The approval ...

  10. Management of oral anticoagulation in patients undergoing minor dental procedures. (United States)

    Alaali, Yathreb; Barnes, Geoffrey D; Froehlich, James B; Kaatz, Scott


    Approximately 4.2 million patients in the United States are taking warfarin, making it the 11th most prescribed drug. Warfarin is primarily used for treatment of venous thromboembolic disease and stroke prevention in patients with atrial fibrillation and mechanical heart valves. Dentists frequently encounter anticoagulated patients and are faced with management decisions in these patients who require dental procedures. Observational studies suggest the risk of thrombosis if anticoagulation is suspended during dental procedures is higher than the risk of bleeding if anticoagulation is not suspended. Several groups now offer guidelines that recommend most minor dental procedures should be performed while on therapeutic warfarin. The recent approval of several new oral anticoagulants has introduced greater complexity to the management of the anticoagulated patient, and this narrative review will discuss current guidelines, the scientific underpinnings of the guidelines, and offer some practical suggestions for patients that are receiving the new agents.

  11. Procedures for the ethical review of public health surveillance protocols

    Directory of Open Access Journals (Sweden)

    Carlo Petrini


    Full Text Available The present commentary is based on the following considerations: 1 for the purposes of authorisation, a distinction is drawn between "research" and "intervention". The procedures for authorising the former are more complex, the relevant controls are stricter and approval has to be granted by a Research Ethics Committee (REC; 2 although the debate is still open, it is barely credible to claim that public health surveillance is not a form of research. It should, therefore, be subject to rigorous ethical assessment; 3 when addressing specifically the issue of surveillance, it would be appropriate to shift the focus of attention from the type of procedure (research/intervention to the risk implied in that procedure; 4 much emphasis has hitherto been placed on the risks that public health surveillance may imply for the protection of personal data; 5 the emphasis on the protection of personal data is frequently excessive and the risks should be examined in a broader context.

  12. 40 CFR 93.114 - Criteria and procedures: Currently conforming transportation plan and TIP. (United States)


    ... conforming transportation plan and TIP. 93.114 Section 93.114 Protection of Environment ENVIRONMENTAL....114 Criteria and procedures: Currently conforming transportation plan and TIP. There must be a currently conforming transportation plan and currently conforming TIP at the time of project approval, or...

  13. 40 CFR 91.424 - Dilute sampling procedure-CVS calibration. (United States)


    ... for Standards and Testing (NIST), and will serve as the reference value (NIST “true” value) for the... approved in advance by the Administrator. (b) After the calibration curve has been obtained, verification...., analyzer calibration, leaks, or HC hangup). A verification procedure is found in paragraph (e) of...

  14. 22 CFR 96.41 - Procedures for responding to complaints and improving service delivery. (United States)


    ... improving service delivery. 96.41 Section 96.41 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES ACCREDITATION OF AGENCIES AND APPROVAL OF PERSONS UNDER THE INTERCOUNTRY ADOPTION ACT OF 2000 (IAA... Management § 96.41 Procedures for responding to complaints and improving service delivery. (a) The agency...

  15. 21 CFR 310.502 - Certain drugs accorded new drug status through rulemaking procedures. (United States)


    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Certain drugs accorded new drug status through... or Devices § 310.502 Certain drugs accorded new drug status through rulemaking procedures. (a) The... meaning of section 201(p) of the act. An approved new drug application under section 505 of the act...

  16. Forenkling af procedurer for klinisk lægemiddelforskning i EU på vej

    DEFF Research Database (Denmark)

    Bach, Karin Friis; Jørgensen, Annette


    to a greater harmonisation within the EU, a more smooth approval procedure, and a lowering of the administrative burden. Details are still to be discussed, and waiting until 2016 when the new rules are adopted is definitely a problem, but all together the new proposal is to be regarded as good news...

  17. [Requirements for drug approval and additional benefits assessment: Regulatory aspects and experiences]. (United States)

    Broich, K; Löbker, W; Schulte, A; Beinlich, P; Müller, T


    The early assessment of benefits of newly approved drugs with novel active substances or new applications, which came into force on 1 January 2011 still represents a challenge to all parties involved. This article highlights the definitions, regulatory requirements and interaction between drug marketing approval and early assessment of benefits in Germany. The constellation of an extensively harmonized European and even international drug authorization process with a predominantly national regulation of drug reimbursement situation inevitably causes friction, which could be markedly reduced through early joint advisory discussions during the planning phase for pivotal clinical trials. During the year 2015 the Federal Institute for Drugs and Medical Devices (BfArM) carried out 300 scientific advice procedures of which 34 were concerned with applications in the field of indications for the central nervous system (CNS). In comparison 98 advisory meetings were held by the Federal Joint Committee (G-BA) of which the BfArM provided advice in 12 instances and in 2 cases on CNS indications. Study design, endpoints and appropriate comparative therapies are the key issues in exchanges and discussions between the BfArM, the G‑BA and applicants. Under these aspects the BfArM and G‑BA promote an early and consistent involvement in early advice procedures regarding the prerequisites for drug approval and assessment of additional benefits.

  18. Robust procedures in chemometrics

    DEFF Research Database (Denmark)

    Kotwa, Ewelina

    -way chemometrical methods, such as PCA and PARAFAC models for analysing spatial and depth profiles of sea water samples, defined by three data modes: depth, variables and geographical location. Emphasis was also put on predicting fluorescence values, as being a natural measure of biological activity, by applying....... applying a multivariate and multi-way data analytical frame-work in fields where less sophisticated data analysis methods are currently used, and 2. developing new, more robust alternatives to already existing multivariate tools. The first part of the study was realised by applying two- and three...... and comparing the Partial Least Squares (PLS) regression technique with its multi-way alternative, N-PLS. Results of the analysis indicated superiority of the three-way frame-work, potentially constituting a novel assessment of the sea water measurements. Particularly in the case of regression models...

  19. Altern als Widerstand

    Directory of Open Access Journals (Sweden)

    Roberta Maierhofer


    Full Text Available Gullettes kulturwissenschaftliche Untersuchung Aged by Culture ist wie bereits ihre zwei vorangehenden Werke, die sich mit Altern beschäftigen – Safe at Last in the Middle Years: The Invention of the Midlife Progress Novel (1988 und Declining to Decline. Cultural Combat and the Politics of the Middle (1997 –, von großem persönlichen Engagement und durch ein politisches Anliegen motiviert. Sowohl die Dringlichkeit als auch der Widerstand, den Gullette, die sich als „age critic“ definiert, als moralische und politische Notwendigkeit postuliert, werden in der Zweiteilung der Abhandlung angesprochen: „Cultural Urgencies“ und „Theorizing Age Resistantly“. Während Gullette den Begriff „aged by culture“ bereits in Declining to Decline einführt, stellt sie ihn nun in den Mittelpunkt ihrer Untersuchung. Das Buch ist einerseits einer gesellschaftspolitischen Analyse der USA gewidmet, andererseits wird eine Theorie des Widerstands gegenüber Altersdiskriminierung entwickelt.

  20. Alternatives to neoliberalism?

    DEFF Research Database (Denmark)

    Warring, Niels; Ahrenkiel, Annegrethe; Nielsen, Birger Steen;

    This paper will discuss the consequences of neoliberal governance in Danish day care centres, the social educators’ response, and the possible development of alternatives based on collective participation of social educators and union representatives. We will show how important and unnoticed...... professional competencies come under pressure, and how collective interest representation is challenged. We will discuss how concepts of “gestural knowledge”, “coherence” and “rhythm” open for a new understanding of professional competence. And we will conclude that the social educators and their unions have...... the possibility to contribute to the development of a new welfare paradigm. The paper is based on material from two research projects (Ahrenkiel et al. 2009, 2011) involving social educators and union representatives in day care institutions. We have observed everyday work activities in day care centres...

  1. Multimedia communications: architectural alternatives (United States)

    McGarty, Terrence P.; Treves, S. T.


    Multimedia communications systems are a combination of human interfaces and end users interacting with multimedia data bases and highly disparate but interconnected communications networks. This paper discusses several architectural alternatives and system requirements that will assist in the design and development of MMCS in actual environments. The approaches taken in this paper are based upon the development of such systems in both medical and printing and publishing environments. This paper develops several key concepts as how best to define and structure data in a multimedia environment, how best to integrate the communications elements, and how best to permit the maximum flexibility to the end user to utilize the system's capabilities in the context of a fully conversational environment.

  2. "Les Grangettes" no longer approved hospital as of 1.1.2012

    CERN Multimedia

    HR Department


    The negotiations for a new tariff agreement with "Les Grangettes", conducted jointly by CERN and partner international organizations, did not reach a positive conclusion. As a result, "Les Grangettes" ceased being an approved hospital on 31 December 2011.   This means that for hospitalizations in "Les Grangettes" as of 1 January 2012 the conditions applicable to unapproved hospitals will apply. In particular: no third-party payment (i.e. you will be charged directly); reimbursement at a fixed 80% rate, whatever the expenses incurred; and expenses incurred will not contribute towards increasing FCA. CHIS members looking for an alternative are invited to consider “Clinique Générale Beaulieu” (located in the same area of Geneva and with which the existing agreement has been extended for 2012 and 2013) or another approved hospital (see the list on the CHIS web site). Note that, as a transitory measur...


    Directory of Open Access Journals (Sweden)

    Maslennikova L. V.


    Full Text Available The author analyses the issue of the relationship between mediated agreements and settlement and their legal inter-relationship, as well as critical comments regarding the lack of imperative requirements in Federal law of the Russian Federation of 27.07.2010 N 193-F3 "On alternative procedure for settling disputes with the use of an intermediary (mediation procedure" to the contents of the mediated settlement agreements which are subsequently endorsed by the arbitral court as settlement agreements

  4. 28 CFR 551.11 - Authority to approve a marriage. (United States)


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Authority to approve a marriage. 551.11... MISCELLANEOUS Marriages of Inmates § 551.11 Authority to approve a marriage. (a) The Warden may approve the marriage of a federal inmate confined in a federal institution. This authority may not be delegated...

  5. 50 CFR 15.26 - Approval of cooperative breeding programs. (United States)


    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Approval of cooperative breeding programs... WILDLIFE AND PLANTS WILD BIRD CONSERVATION ACT Permits and Approval of Cooperative Breeding Programs § 15.26 Approval of cooperative breeding programs. Upon receipt of a complete application, the...

  6. 12 CFR 614.4470 - Loans subject to bank approval. (United States)


    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Loans subject to bank approval. 614.4470 Section 614.4470 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Loan Approval Requirements § 614.4470 Loans subject to bank approval. (a) The following...

  7. 14 CFR 21.269 - Export airworthiness approvals. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Export airworthiness approvals. 21.269 Section 21.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION....269 Export airworthiness approvals. The manufacturer may issue export airworthiness approvals....

  8. 76 FR 53526 - Projects Approved for Consumptive Uses of Water (United States)


    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  9. 76 FR 42159 - Projects Approved for Consumptive Uses of Water (United States)


    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  10. 27 CFR 24.26 - Authority to approve. (United States)


    ..., DEPARTMENT OF THE TREASURY LIQUORS WINE Administrative and Miscellaneous Provisions Authorities § 24.26 Authority to approve. The appropriate TTB officer is authorized to approve, except as otherwise provided in... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Authority to approve....

  11. 48 CFR 32.409-1 - Recommendation for approval. (United States)


    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Recommendation for... Recommendation for approval. If recommending approval, the contracting officer shall transmit the following... authorization (see 32.410). (g) The recommendation for approval of the advance payment request....

  12. 8 CFR 207.6 - Control over approved refugee numbers. (United States)


    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Control over approved refugee numbers. 207... ADMISSION OF REFUGEES § 207.6 Control over approved refugee numbers. Current numerical accounting of approved refugees is maintained for each special group designated by the President. As refugee status...

  13. 29 CFR 4211.21 - Changes subject to PBGC approval. (United States)


    ... method or modification to an allocation method that is not permitted under § 4211.12 if the method or... 29 Labor 9 2010-07-01 2010-07-01 false Changes subject to PBGC approval. 4211.21 Section 4211.21... Subject to PBGC Approval § 4211.21 Changes subject to PBGC approval. (a) General rule. Subject to...

  14. 44 CFR 78.9 - Planning grant approval process. (United States)


    ... MITIGATION ASSISTANCE § 78.9 Planning grant approval process. The State POC will evaluate and approve... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Planning grant approval process. 78.9 Section 78.9 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT...

  15. 46 CFR 188.10-3 - Approved container. (United States)


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Approved container. 188.10-3 Section 188.10-3 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-3 Approved container. This term means a container which is properly labeled, marked and approved by DOT for the commodity which it contains....

  16. 7 CFR 996.22 - USDA-approved laboratory. (United States)


    ... 7 Agriculture 8 2010-01-01 2010-01-01 false USDA-approved laboratory. 996.22 Section 996.22 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... laboratory. USDA-approved laboratory means laboratories approved by the Science and Technology...

  17. Differential Reinforcement of Alternative Behavior in Center-Based Classrooms: Evaluation of Pre-Teaching the Alternative Behavior (United States)

    LeGray, Matthew W.; Dufrene, Brad A.; Mercer, Sterett; Olmi, D. Joe; Sterling, Heather


    This study investigated the effectiveness of a differential reinforcement of alternative behavior procedure in decreasing disruptive behavior while simultaneously increasing the appropriate behavior of four children of typical development between the ages of 4 and 6 in center-based classrooms. We began with brief functional analyses for each…

  18. Crown lengthening procedures

    Directory of Open Access Journals (Sweden)

    AA. Khoshkhonejad


    Full Text Available Nowadays, due to recent developments and researches in dental science, it is possible to preserve and restore previously extracted cases such as teeth with extensive caries, fractured or less appropriate cases for crown coverage as well as teeth with external perforation caused by restorative pins. In order to restore the teeth with preservation of periodontium, we should know thoroughly physiological aspects of periodontium and protection of Biologic Width which is formed by epithelial and supracrestal connective tissue connections. Considering biologic width is one of the principal rules of teeth restoration, otherwise we may destruct periodontal tissues. Several factors are involved in placing a restoration and one of the most important ones is where the restoration margin is terminated. Many studies have been conducted on the possible effects of restoration margin on the gingiva and due to the results of these studies it was concluded that restoration margin should be finished supragingivally. However, when we have to end the restoration under Gingival Crest, First a healthy gingival sulcus is required. Also, we should not invade the biological width. Since a normal biologic with is reported 2 mm and sound tooth tissue should be placed at least 2 mm coronal to the epithelial tissue, the distance between sound tooth tissue and crown margin should be at least 4mm. Thus, performing crown lengthening is essential to increase the clinical crown length. Basically, two objectives are considered: 1 restorative 2 esthetic (gummy smile Surgical procedure includes gingivectomy and flap procedure. Orthodontic procedure involves orthodontic extrusion or force eruption technique which is controlled vertical movements of teeth into occlusion. Besides, this procedure can also used to extrude teeth defects from the gingival tissue. By crown lengthening, tooth extraction is not required and furthermore, adjacent teeth preparation for placing a fixed

  19. Ordering alternatives in MCDM problems

    Energy Technology Data Exchange (ETDEWEB)

    De Baets, B. [Ghent Univ. (Belgium). Dept. of Applied Mathematics and Computer Science


    A new approach to the study of a set of alternatives in a multi-criteria decision making problem is presented. Alternatives are described by means of fuzzy sets in the set of criteria, expressing the degrees to which they fulfill the different criteria. The concept of a fuzzy inclusion is introduced and is discussed from an axiomatic point of view. To each implication operator corresponds a fuzzy inclusion. The fuzzy inclusion corresponding to the Goedel operator is used to measure the degree to which the scores of one alternative are contained in the scores of another one. Repeating this for all couples of alternatives yields a fuzzy quasi-order relation in a set of alternatives. The cuts of this fuzzy relation are then classical quasi-order relations: they express orderings of the alternatives, allowing alternatives to be indifferent or incomparable, corresponding to different degrees of confidence.

  20. Loop electrosurgical excisional procedure. (United States)

    Mayeaux, E J; Harper, M B


    Loop electrosurgical excisional procedure, or LEEP, also known as loop diathermy treatment, loop excision of the transformation zone (LETZ), and large loop excision of the transformation zone (LLETZ), is a new technique for outpatient diagnosis and treatment of dysplastic cervical lesions. This procedure produces good specimens for cytologic evaluation, carries a low risk of affecting childbearing ability, and is likely to replace cryotherapy or laser treatment for cervical neoplasias. LEEP uses low-current, high-frequency electrical generators and thin stainless steel or tungsten loops to excise either lesions or the entire transformation zone. Complication rates are comparable to cryotherapy or laser treatment methods and include bleeding, incomplete removal of the lesion, and cervical stenosis. Compared with other methods, the advantages of LEEP include: removal of abnormal tissue in a manner permitting cytologic study, low cost, ease of acquiring necessary skills, and the ability to treat lesions with fewer visits. Patient acceptance of the procedure is high. Widespread use of LEEP by family physicians can be expected.

  1. The calcaneo-stop procedure. (United States)

    Usuelli, F G; Montrasio, U Alfieri


    Flexible flatfoot is one of the most common deformities. Arthroereisis procedures are designed to correct this deformity. Among them, the calcaneo-stop is a procedure with both biomechanical and proprioceptive properties. It is designed for pediatric treatment. Results similar to endorthesis procedure are reported. Theoretically the procedure can be applied to adults if combined with other procedures to obtain a stable plantigrade foot, but medium-term follow up studies are missing.

  2. Securing classification and regulatory approval for deepwater projects: management challenges in a global environment

    Energy Technology Data Exchange (ETDEWEB)

    Feijo, Luiz P.; Burton, Gareth C. [American Bureau of Shipping (ABS), Rio de Janeiro, RJ (Brazil)


    As the offshore industry continues to develop and move into increasingly deeper waters, technological boundaries are being pushed to new limits. Along with these advances, the design, fabrication and installation of deepwater oil and gas projects has become an increasingly global endeavor. After providing an overview of the history and role of Classification Societies, this paper reviews the challenges of securing classification and regulatory approval in a global environment. Operational, procedural and technological changes which one Classification Society; the American Bureau of Shipping, known as ABS, has implemented to address these challenges are presented. The result of the changes has been a more customized service aiming at faster and more streamlined classification approval process. (author)

  3. How do patent rights affect regulatory approvals and data exclusivity rights for pharmaceuticals in the EU? (United States)

    Bogaert, Peter; Van Keymeulen, Eveline


    This article sheds light on the relationship, or rather, absence of a relationship, between patent rights and regulatory approval procedures in the EU. The principle of 'patent linkage' has long been recognized and applied by regulatory authorities in the USA. The European Commission, however, opposes the idea of linking patent rights to marketing authorizations and pricing and reimbursement decisions. This position is grounded in Article 126 of Directive 2001/83 and is expected not to change anytime soon, given the clear reaffirmation thereof in the recent Sector Inquiry Report and Transparency Directive Proposal. Therefore, the European Medicines Agency or national authorities are not permitted to refuse approval and, likely, pricing and reimbursement of a generic when the innovative reference product is still protected by a patent. The authors, however, advocate that there are strong legal arguments for patent holders to challenge regulatory decisions that did not respect their patent rights before the competent national courts.

  4. One Stop Centre as a Boon to Property Development Approval Process. A Case Study:City Hall of Kuala Lumpur

    Directory of Open Access Journals (Sweden)

    Ibrahim Mohd @ Ahmad


    Full Text Available The delays in obtaining local authority approvals for land development have become a universal issue in the property development sector. In the past decades, the approval process in Malaysia was accused of having cumbersome and inconsistency procedures. Recently, the Ministry of Housing and Local Government has introduced a new processing system as the innovative initiative called One Stop Centre (OSC in each local authority meant to expedite the planning, building and land development approval process concurrently. This study seeks to answer to the question of its achievement towards solving the problems since the OSC was implemented in 2007. The data were obtained through semi-structured questionnaire survey to clients of the OSC and the local authority planning officers. Findings of this study have highlighted that there are positive outcomes towards achieving the objective of its establishment but some areas in the process need immediate attentions.

  5. Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields (United States)

    Reinscheid, Uwe M.


    The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.

  6. Sincere Voting with Cardinal Preferences: Approval Voting


    Ballester, Miguel Angel; Rey-Biel, Pedro


    We discuss sincere voting when voters have cardinal preferences over alter- natives. We interpret sincerity as opposed to strategic voting, and thus define sincerity as the optimal behaviour when conditions to vote strategically vanish. When voting mechanisms allow for only one message type we show that this op- timal behaviour coincides with an intuitive and common definition of sincerity. For voting mechanisms allowing for multiple message types, such as approval vot- ing (AV), there exists...

  7. Thiazolidinediones: a comparative review of approved uses. (United States)

    Sood, V; Colleran, K; Burge, M R


    Thiazolidinediones are a powerful and clinically important new class of oral antidiabetic agents that act by improving insulin sensitivity. Troglitazone is the prototype drug in this class but was withdrawn from the market in March 2000 due to its association with idiosyncratic hepatotoxicity. Currently two thiazolidinediones, rosiglitazone and pioglitazone, are U.S. Food and Drug Administration (FDA) approved for treatment of type 2 diabetes. These agents bind to and activate peroxisome proliferator-activator receptor gamma (PPAR-gamma) and work by altering the expression of genes involved in glucose uptake, glucose disposal, and lipid metabolism. The drugs differ in receptor binding and potency due to differences in their side chain moieties. These agents are rapidly absorbed from the gastrointestinal tract and are metabolized mainly in the liver. Rosiglitazone is FDA approved for monotherapy and for use in combination therapy with metformin or sulfonylureas. Pioglitazone is FDA approved for monotherapy as well as for use in combination therapy with metformin, insulin, or sulfonylureas. These drugs may also cause significant changes in plasma lipid concentrations, and improved insulin sensitivity may improve ovulatory function and fertility in women with polycystic ovary syndrome. The most serious side effect of the thiazolidinediones is hepatotoxicity. Although rosiglitazone and pioglitazone were not associated with hepatotoxicity in premarketing clinical trials, there were two recent case reports of idiosyncratic hepatotoxicity in patients treated with rosiglitazone. In addition, these agents may be associated with edema and some hematological changes. The purpose of this review is to provide an overview of the two currently approved thiazolidinediones and to suggest an approach for their safe and rational use.

  8. Detecting alternative graph clusterings. (United States)

    Mandala, Supreet; Kumara, Soundar; Yao, Tao


    The problem of graph clustering or community detection has enjoyed a lot of attention in complex networks literature. A quality function, modularity, quantifies the strength of clustering and on maximization yields sensible partitions. However, in most real world networks, there are an exponentially large number of near-optimal partitions with some being very different from each other. Therefore, picking an optimal clustering among the alternatives does not provide complete information about network topology. To tackle this problem, we propose a graph perturbation scheme which can be used to identify an ensemble of near-optimal and diverse clusterings. We establish analytical properties of modularity function under the perturbation which ensures diversity. Our approach is algorithm independent and therefore can leverage any of the existing modularity maximizing algorithms. We numerically show that our methodology can systematically identify very different partitions on several existing data sets. The knowledge of diverse partitions sheds more light into the topological organization and helps gain a more complete understanding of the underlying complex network.

  9. Alternative nuclear technologies (United States)

    Schubert, E.


    The lead times required to develop a select group of nuclear fission reactor types and fuel cycles to the point of readiness for full commercialization are compared. Along with lead times, fuel material requirements and comparative costs of producing electric power were estimated. A conservative approach and consistent criteria for all systems were used in estimates of the steps required and the times involved in developing each technology. The impact of the inevitable exhaustion of the low- or reasonable-cost uranium reserves in the United States on the desirability of completing the breeder reactor program, with its favorable long-term result on fission fuel supplies, is discussed. The long times projected to bring the most advanced alternative converter reactor technologies the heavy water reactor and the high-temperature gas-cooled reactor into commercial deployment when compared to the time projected to bring the breeder reactor into equivalent status suggest that the country's best choice is to develop the breeder. The perceived diversion-proliferation problems with the uranium plutonium fuel cycle have workable solutions that can be developed which will enable the use of those materials at substantially reduced levels of diversion risk.

  10. Hospital diversification: evaluating alternatives. (United States)

    Hammer, L


    The appropriateness of diversification as a growth strategy for hospitals is discussed, and planning for diversification is described. Because new forms of health-care delivery are now in direct competition with hospitals, many hospitals are confronting environmental pressures and preparing for future survival through diversification. To explore the potential risks and benefits of diversification, the hospital must identify opportunities for new business ventures. Diversification can be "related," through an expansion of the primary product line (health care), or "unrelated," into areas not directly associated with health care. The hospital must establish specific criteria for evaluating each diversification alternative, and the two or three most attractive options should be analyzed further through a financial feasibility study. The hospital should also seek legal advice to determine the implications of diversification for maintenance of tax status, antitrust limitations, and applicability of certificate of need. Although diversification may not be appropriate for every institution, hospitals should consider it as a strategy for increasing their revenue base, confronting environmental pressures, and securing future survival.

  11. Alternating hemiplegia of childhood. (United States)

    Kansagra, Sujay; Mikati, Mohamad A; Vigevano, Federico


    Alternating hemiplegia of childhood (AHC) is a very rare disease characterized by recurrent attacks of loss of muscular tone resulting in hypomobility of one side of the body. The etiology of the disease due to ATP1A3 gene mutations in the majority of patients. Few familial cases have been described. AHC has an onset in the first few months of life. Hemiplegic episodes are often accompanied by other paroxysmal manifestations, such as lateral eyes and head deviation toward the hemiplegic side and a very peculiar monocular nystagmus. As the attack progresses, hemiplegia can shift to the other side of the body. Sometimes the attack can provoke bilateral paralysis, and these patients may have severe clinical impairment, with difficulty in swallowing and breathing. Hemiplegic attacks may be triggered by different stimuli, like bath in warm water, motor activity, or emotion. The frequency of attacks is high, usually several in a month or in a week. The duration is variable from a few minutes to several hours or even days. Sleep can stop the attack. Movement disorders such as dystonia and abnormal movements are frequent. Cognitive delay of variable degree is a common feature. Epilepsy has been reported in 50% of the cases, but seizure onset is usually during the third or fourth year of life. Many drugs have been used in AHC with very few results. Flunarizine has the most supportive anecdotal evidence regarding efficacy.

  12. Alternative HTS coated conductors (United States)

    Blaugher, R. D.; Bhattacharya, R. N.; Chen, J.; Padmanabhan, R.


    The availability of Bi-2223 high-temperature-superconductor (HTS) powder-in-tube (PIT) tape, with acceptable performance for long lengths, has provided the ability to construct a wide range of HTS electric power components. As a result, there are major worldwide projects in developing HTS electric power components for demonstration in a utility environment. Utility acceptance for superconducting power equipment will depend on several key factors: improved system performance, lower life-cycle costs, higher efficiency versus conventional technology, reliability and maintenance comparable to conventional power equipment, and a competitive installed cost. The latter is impacted by the current high cost of HTS conductors, which must be lowered to costs comparable to conventional Nb-Ti wire, i.e., $2-5/kAm. The present performance and cost of state-of-the-art Bi-2223 HTS tape, although acceptable for prototype construction, is viewed as a major deterrent that may compromise eventual commercialization for most of these electric power devices. The so-called second-generation coated conductor development, with emphasis on conductors employing HTS YBCO films, is viewed as the solution to this performance and cost issue. The potential for the Tl, Hg, and Bi-oxide superconductors for producing an HTS tape as alternatives to Bi-2223 PIT (and YBCO) will be discussed with some recent results on Bi-2212 “coated conductor” development.

  13. Enhanced Design Alternative IV

    Energy Technology Data Exchange (ETDEWEB)

    N. E. Kramer


    This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the ''Design Input Request for LADS Phase II EDA Evaluations'' (CRWMS M&O 1999b) and (CRWMS M&O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as ''line load''. Continuous pre-closure ventilation keeps the waste packages from exceeding the 350 C cladding and 200 C (4.3.13) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and a drip shields will be emplaced at closure to improve post-closure performance.

  14. Alternative Compression Garments (United States)

    Stenger, M. B.; Lee, S. M. C.; Ribeiro, L. C.; Brown, A. K.; Westby, C. M.; Platts, S. H.


    Orthostatic intolerance after spaceflight is still an issue for astronauts as no in-flight countermeasure has been 100% effective. Future anti-gravity suits (AGS) may be similar to the Shuttle era inflatable AGS or may be a mechanical compression device like the Russian Kentavr. We have evaluated the above garments as well as elastic, gradient compression garments of varying magnitude and determined that breast-high elastic compression garments may be a suitable replacement to the current AGS. This new garment should be more comfortable than the AGS, easy to don and doff, and as effective a countermeasure to orthostatic intolerance. Furthermore, these new compression garments could be worn for several days after space flight as necessary if symptoms persisted. We conducted two studies to evaluate elastic, gradient compression garments. The purpose of these studies was to evaluate the comfort and efficacy of an alternative compression garment (ACG) immediately after actual space flight and 6 degree head-down tilt bed rest as a model of space flight, and to determine if they would impact recovery if worn for up to three days after bed rest.


    Directory of Open Access Journals (Sweden)

    Daniela Cristina Creţ


    Full Text Available One of the institutions to have undergone essential changes as a result of the 2013 entry into force of the New Code of civil procedure is arbitration. Arbitration is an alternative way of settling conflicts by means of a specialized person or institution, based on the will of the parties or on an international convention. This article will present a few introductory aspects that are essential for a foray into the field, as well as analyze the main aspects of arbitral procedure from the perspective of novelties and changes brought to the provisions of the New Code of civil procedure (hereinafter referred to as N.C.C.P..

  16. Using the Multiple Choice Procedure to Measure College Student Gambling (United States)

    Butler, Leon Harvey


    Research suggests that gambling is similar to addictive behaviors such as substance use. In the current study, gambling was investigated from a behavioral economics perspective. The Multiple Choice Procedure (MCP) with gambling as the target behavior was used to assess for relative reinforcing value, the effect of alternative reinforcers, and…

  17. 33 CFR 155.750 - Contents of transfer procedures. (United States)


    ...) Exemptions or alternatives granted must be placed in the front of the transfer procedures. (c) The vessel... accordance with 46 CFR 39.30-1(d) (1) through (d)(3); (4) The initial transfer rate for each tank that complies with 46 CFR 39.30-1(h); (5) A table or graph of transfer rates and corresponding vapor...

  18. Application of alternative medicine in gastrointestinal cancer patients

    Directory of Open Access Journals (Sweden)

    Nikolić Ivan


    Full Text Available Bacground/Aim. Alternative medicine is a set of therapeutic procedures which are no part of official practice. At present, the use of alternative medicine among cancer patients is significant and the purpose of this study was to get more information on the methods and products of alternative medicine. Thus, the aim of the study was to determine the frequency of the use of alternative medicine among gastrointestinal cancer patients. Methods. The research was conducted using an anonymous questionnaire in writing. We included 205 patients with the diagnosis of gastrointestinal malignancy in the study but the questionnaire was fulfilled by 193 patients and the presented data were based on their answers. The questions were about the sociodemographic characteristics of the patients, the reasons for their use of alternative medicine, and their information sources about alternative medicine. We divided existing alternative therapies into 6 categories: herbal therapy, special diets, psychotherapy, body-mind therapy, spiritual therapy, and other supplements. Results. A total of 48 (24.9% patients did not use any type of alternative therapy; 145 (75.1% patients used at least one product and 124 (64.25% patients used herbal preparations (beetroot juice was consumed by 110 [56.99%] patients; 136 (70.5% patients were informed about alternative therapies by other patients.; 145 (75.1% used alternative medicine to increase the chances for cure; 88 (45.6% of interviewed patients would like to participate in future research in this field. Conclusion. The use of alternative medicine is evidently significant among cancer patients. Further research should be conducted in order to find out interactions of these products with other drugs and potential advantages and disadvantages of this form of treatment.

  19. CELT optics Alignment Procedure (United States)

    Mast, Terry S.; Nelson, Jerry E.; Chanan, Gary A.; Noethe, Lothar


    The California Extremely Large Telescope (CELT) is a project to build a 30-meter diameter telescope for research in astronomy at visible and infrared wavelengths. The current optical design calls for a primary, secondary, and tertiary mirror with Ritchey-Chretién foci at two Nasmyth platforms. The primary mirror is a mosaic of 1080 actively-stabilized hexagonal segments. This paper summarizes a CELT report that describes a step-by-step procedure for aligning the many degrees of freedom of the CELT optics.

  20. Interventional radiology neck procedures. (United States)

    Zabala Landa, R M; Korta Gómez, I; Del Cura Rodríguez, J L


    Ultrasonography has become extremely useful in the evaluation of masses in the head and neck. It enables us to determine the anatomic location of the masses as well as the characteristics of the tissues that compose them, thus making it possible to orient the differential diagnosis toward inflammatory, neoplastic, congenital, traumatic, or vascular lesions, although it is necessary to use computed tomography or magnetic resonance imaging to determine the complete extension of certain lesions. The growing range of interventional procedures, mostly guided by ultrasonography, now includes biopsies, drainages, infiltrations, sclerosing treatments, and tumor ablation.


    Directory of Open Access Journals (Sweden)



    Full Text Available Because of the big damages on the ozone layer given by the refrigerants cloroflorocarbons that has been used up to now, new alternative gases should be developped and product at once. In this study, some informations about alternative to presently used CFCs, R-134A refrigerant's characteristics and its suitability to cooling systems is given. As it would be understood from these informations there is no objection on using alternative R-134A refrigerant

  2. How often are ethics approval and informed consent reported in publications on health research in Cameroon? A five-year review. (United States)

    Munung, Nchangwi Syntia; Che, Chi Primus; Ouwe-Missi-Oukem-Boyer, Odile; Tangwa, Godfrey B


    We assessed the extent of research ethics approval and informed consent reporting in publications emanating from Cameroon and indexed in PubMed from 2005-2009. In our review of 219 full-length articles, we found that 57.53% reported ethics approval, 70.78% informed consent, and 50.68% both ethics approval and informed consent. Reporting these procedures was more common in randomized clinical trials than in other study designs. Also, 59.52% of the articles on vulnerable populations documented ethics approval and 76.19% documented informed consent. This study also identified some structures for ethics review and recommends some next steps for research on the quality of ethics review in Cameroon.

  3. Regulations and Procedures Manual

    Energy Technology Data Exchange (ETDEWEB)

    Young, Lydia J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)


    The purpose of the Regulations and Procedures Manual (RPM) is to provide LBNL personnel with a reference to University and Lawrence Berkeley National Laboratory (LBNL or Laboratory) policies and regulations by outlining normal practices and answering most policy questions that arise in the day-to-day operations of Laboratory organizations. Much of the information in this manual has been condensed from detail provided in LBNL procedure manuals, Department of Energy (DOE) directives, and Contract DE-AC02-05CH11231. This manual is not intended, however, to replace any of those documents. RPM sections on personnel apply only to employees who are not represented by unions. Personnel policies pertaining to employees represented by unions may be found in their labor agreements. Questions concerning policy interpretation should be directed to the LBNL organization responsible for the particular policy. A link to the Managers Responsible for RPM Sections is available on the RPM home page. If it is not clear which organization is responsible for a policy, please contact Requirements Manager Lydia Young or the RPM Editor.

  4. Regulations and Procedures Manual

    Energy Technology Data Exchange (ETDEWEB)

    Young, Lydia [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)


    The purpose of the Regulations and Procedures Manual (RPM) is to provide Laboratory personnel with a reference to University and Lawrence Berkeley National Laboratory policies and regulations by outlining the normal practices and answering most policy questions that arise in the day-to-day operations of Laboratory departments. Much of the information in this manual has been condensed from detail provided in Laboratory procedure manuals, Department of Energy (DOE) directives, and Contract DE-AC02-05CH11231. This manual is not intended, however, to replace any of those documents. The sections on personnel apply only to employees who are not represented by unions. Personnel policies pertaining to employees represented by unions may be found in their labor agreements. Questions concerning policy interpretation should be directed to the department responsible for the particular policy. A link to the Managers Responsible for RPM Sections is available on the RPM home page. If it is not clear which department should be called, please contact the Associate Laboratory Director of Operations.

  5. Designing Flight Deck Procedures (United States)

    Degani, Asaf; Wiener, Earl


    Three reports address the design of flight-deck procedures and various aspects of human interaction with cockpit systems that have direct impact on flight safety. One report, On the Typography of Flight- Deck Documentation, discusses basic research about typography and the kind of information needed by designers of flight deck documentation. Flight crews reading poorly designed documentation may easily overlook a crucial item on the checklist. The report surveys and summarizes the available literature regarding the design and typographical aspects of printed material. It focuses on typographical factors such as proper typefaces, character height, use of lower- and upper-case characters, line length, and spacing. Graphical aspects such as layout, color coding, fonts, and character contrast are discussed; and several cockpit conditions such as lighting levels and glare are addressed, as well as usage factors such as angular alignment, paper quality, and colors. Most of the insights and recommendations discussed in this report are transferable to paperless cockpit systems of the future and computer-based procedure displays (e.g., "electronic flight bag") in aerospace systems and similar systems that are used in other industries such as medical, nuclear systems, maritime operations, and military systems.

  6. Alternative fuelds in urban fleets

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, T.


    In this presentation the author addresses four main objectives. They are to: discuss programs that are driving the introduction of alternative fuels into fleet operations in urban areas around the country; define alternative fuels; quantify the present use and future projections on alternative fuel vehicles (AVFs) in the Chicago metropolitan statistical area; and discuss benefits of increased use of alternative fuels in urban areas. Factors which touch on these points include: present domestic dependence on petroleum for autos, with usage exceeding production; the large populations in urban areas which do not meet Clean Air Standards; recent legislative initiatives which give guidance and aid in the adoption of such strategies.

  7. Private Housing or Alternative Financing? (United States)

    Bruno, Nick


    Explores the history of privatizing university housing and some current financing options, including use of developer and private foundations. Examples of successful alternative financing methods are highlighted. (GR)

  8. Utilization of reconstructed cultured human skin models as an alternative skin for permeation studies of chemical compounds


    Kano, Satoshi; 藤堂, 浩明; 杉江, 謙一; 藤本, 英哲; 中田, 圭一; 徳留, 嘉寛; 橋本, フミ惠; 杉林, 堅次


    Two reconstructed human skin models, EpiskinSM and EpiDermTM, have been approved as alternative membranes for skin corrosive/irritation experiments due to their close correlation with animal skin. Such reconstructed human skin models were evaluated as alternative membranes for skin permeation experiments. Seven drugs with different lipophilicities and almost the same molecular weight were used as test penetrants. Relationships were investigated between permeability coefficients (P values) of ...

  9. The Ross II procedure: pulmonary autograft in the mitral position. (United States)

    Athanasiou, Thanos; Cherian, Ashok; Ross, Donald


    The surgical management of mitral valve disease in women of childbearing age, young patients, and children with congenital mitral valve defects is made difficult by the prospect of lifelong anticoagulation. We suggest the use of a pulmonary autograft in the mitral position (Ross II procedure) as an alternative surgical technique. We present a review of the literature, historical perspectives, indications, selection criteria, and surgical technique for the Ross II procedure. Our literature search identified 14 studies that reported results from the Ross II operation. Performed in 103 patients, the overall in-hospital mortality was 7 (6.7%), with a late mortality of 10 (9%). Although further research is needed, current evidence suggests the Ross II operation is a valuable alternative in low-risk young patients where valve durability and the complication rate from other procedures is unsatisfactory and anticoagulation not ideal.

  10. Procedural Skills Education – Colonoscopy as a Model

    Directory of Open Access Journals (Sweden)

    Maitreyi Raman


    Full Text Available Traditionally, surgical and procedural apprenticeship has been an assumed activity of students, without a formal educational context. With increasing barriers to patient and operating room access such as shorter work week hours for residents, and operating room and endoscopy time at a premium, alternate strategies to maximizing procedural skill development are being considered. Recently, the traditional surgical apprenticeship model has been challenged, with greater emphasis on the need for surgical and procedural skills training to be more transparent and for alternatives to patient-based training to be considered. Colonoscopy performance is a complex psychomotor skill requiring practioners to integrate multiple sensory inputs, and involves higher cortical centres for optimal performance. Colonoscopy skills involve mastery in the cognitive, technical and process domains. In the present review, we propose a model for teaching colonoscopy to the novice trainee based on educational theory.

  11. Tableau-based decision procedures for logics of strategic ability in multi-agent systems

    CERN Document Server

    Goranko, Valentin


    We develop decision procedures based on sound, complete, and terminating incremental tableaux for the satisfiability problem of the Alternating-time temporal logic ATL and related modal logics for reasoning about abilities of agents in multiagent systems.

  12. Health economic analysis of laparoscopic lavage versus Hartmann's procedure for diverticulitis in the randomized DILALA trial

    DEFF Research Database (Denmark)

    Gehrman, J; Angenete, E; Björholt, I;


    BACKGROUND: Open surgery with resection and colostomy (Hartmann's procedure) has been the standard treatment for perforated diverticulitis with purulent peritonitis. In recent years laparoscopic lavage has emerged as an alternative, with potential benefits for patients with purulent peritonitis...

  13. The mediation procedure in Romania

    Directory of Open Access Journals (Sweden)

    Alexandrina Zaharia


    Full Text Available The mediation activity as an alternative way of solving conflicts occupies an important place in modernsociety. Currently, the mediation reached its maturity worldwide being adopted without reservations.The future of solving conflicts is undoubtedly closely related to mediation. XXth century is the century of solvingconflicts amiably outside the court room. In Romania and the mediation profession were regulated by the Law no.192/2006, on the basis of the idea that mediation is one of the major themes of the reform strategy of the judicialsystem 2005-2007. By adopting the mentioned law it was followed the idea of reducing the volume of activitycourts, and therefore, relieve them of as many cases, with the direct effect on the quality of justice. Mediation is avoluntary process in which the parties with a neutral and impartial third party, without power of decision - themediator - who is qualified to assist the parties to negotiate, facilitating the communication between them andhelping them to reach a unanimous effective and sustainable agreement. The parties may resort to mediation beforeor after triggering a trial. Mediation can be applied, in principle, on any type of conflict. However, theRomanian legislator has established special stipulations on conflict mediation in criminal, civil and familylaw. Although not expressly provided, the stipulations regarding the civil conflicts and also apply to commercialconflicts. Therefore, the mediation is applicable to most types of lawsuits, except those relating to personalrights. As a "win- win" principle, the mediation does not convert any of the parties defeated or victorious; allthose involved have gained by applying this procedure.

  14. Alternative energy in Nepal

    Energy Technology Data Exchange (ETDEWEB)

    Tiwari, H.B.; Bhandari, K.P.


    Renewable energy Technology (RET) becomes the mainstream option for rural Nepal to access modern source of energy. It focuses on the trend of RET applications consisting of biogas technology, solar thermal, micro and Pico hydropower, biomass technology bio fuel technology, wind power technology etc. The RET's which provide both electricity based as well as non electricity based services, have been shown to most immediately meet the needs of a cleaner indoor environment, better quality lightning for education and income generating, activities, alternative cooking fuels and agro processing as well as rural industries. Improved cooking stoves and much more beneficial than other technologies. Wind energy utilization is still not popular. Solar thermal to generate thermal energy to cook, warm and dry, biogas for lighting and cooking services. Micro hydropower for electric as well as mechanical use and solar PV mainly for domestic lighting may become choice. The most important Renewable Energy Technology (RET's) in Nepal are related to Pico hydropower and micro-hydropower, biomass energy (biogas, briquettes, gasifies, improved cooking stoves, bio-fuels etc.) solar photovoltaic energy, solar PV water pumping, solar thermal energy (solar heater, solar dryers, solar cookers etc.) and wind energy (such as wind generators, wind mills etc.). One renowned Non-governmental organization has been established in the Jhapa and Mornag Bhutanese refugee camp. Two families from all the seven camps in Nepal received one solar cooker, one hay box and two cooking posts to each family. Under this programme, a total of 6,850 solar cookers, 12600 hay boxes and 25,200 cooking pots have been distributed 2009. The number of beneficiaries from this program has reached 85,000. Before the distribution of the cookers and the utensils, the instruction and orientation training for the maintenance and repair and operation method was improved. The refugees were divided in 315 groups of 40

  15. Mini-donor nephrectomy: A viable and effective alternative

    Directory of Open Access Journals (Sweden)

    Sandeep Guleria


    Full Text Available Live kidney donation is an excellent way of increasing the donor pool. The introduction of the laparoscopic donor nephrectomy has resulted in an increase in live organ donation in the western hemisphere. There is no data on its impact on organ donation in India. However attractive as it may seem, the procedure is associated with a definite learning curve and does compromise donor safety. The procedure is also expensive in terms of the equipment required. The mini-donor nephrectomy is an excellent alternative, has no learning curve and is ideally suited for donors in India who have a low BMI. The procedure is also relatively inexpensive. We are in need of a donor registry rather than reports from single institutions to fully evaluate the risks and benefits of both procedures.

  16. Economic assessment of alternatives for glyphosate application in arable farming

    Directory of Open Access Journals (Sweden)

    Kehlenbeck, Hella


    Full Text Available Application and sales of herbicides with glyphosate have strongly increased in Germany during the past 10 years. This has raised a number of questions and discussions concerning glyphosate use. Therefore, this paper identifies and evaluates alternatives with an efficacy almost equivalent to glyphosate for different treatmentareas in terms of economic consequences for farms in comparison to glyphosate use by way of example. With the help of exemplary crop rotations uses in arable farming for winter wheat, winter oilseed rape, winter barley, maize and summer barley were analyzed. Within a “worst case scenario” a complete abandonment of glyphosate applications was assumed. Different tillage systems (plough, no-plough were considered. The only alternatives with an efficacy almost equivalent to glyphosate were mechanical measures. For the analyzed treatment-areas (desiccation, pre-sowing, stubble no approved and efficient chemical alternative could be identified. The economic advantages and disadvantages of substituting glyphosate by mechanical alternatives were strongly depending on the treatment-area, the efficacy concerning yield expectations (in comparison to glyphosate use, the tillage system, the necessity of grain drying as well as further operational factors such as the availability of sufficient field work days and mechanical equipment.

  17. ATP-bioluminescence assay as an alternative for hygiene-monitoring procedures of stainless steel milk contact surfaces Técnica do ATP-bioliminescência como uma alternativa para o monitoramento do procedimento de higienização de superfícies de aço inoxidável na indústria de laticínios

    Directory of Open Access Journals (Sweden)

    Patrícia Dolabela Costa


    Full Text Available ATP-bioluminescence assay was used to evaluate the cleaning and sanitizing procedures of stainless steel milk contact surfaces. Surfaces of a raw milk transportation tank, a raw milk cooling storage tank, an equalization pasteurizing tank, a pasteurized milk storage tank and a pasteurized milk packaging tank, as well as a milk centrifuge were evaluated. The Relative Light Unit (RLU using a commercial luminometer and mesophilic aerobic counts ( on surfaces were determined. There were no significant differences (p>0.05 in RLU on the assessed surfaces before and after the cleaning and sanitizing procedures. Also, there were no significant differences (p>0.05 in on the surfaces before the cleaning and sanitizing procedures, whereas different bacterial numbers were found on surfaces after the hygiene procedures. The surfaces of the milk centrifuge, raw milk cooling tank and milk packaging tank showed the largest mesophilic aerobic numbers after the hygiene, reaching 2.21, 2.18, and 1.21 log10, respectively. The results demonstrated that there is no agreement among the techniques for classification of hygienic conditions of the evaluated surfaces, showing a non-direct relation between RLU and The ATP-bioluminescence method showed that 100% of the surfaces were under inadequate hygiene conditions, while the plate count method detected only 50%, based on the APHA's recommendation, and 33%, based on the WHO's recommendation. High variations in RLU measurements were observed, suggesting the need for more than only one surface analysis. The ATP-bioluminescence is not a direct replacement for microbiological testing, but provides complementary information and should be used as part of an integrated strategy.A técnica do ATP-bioluminescência avaliou os procedimentos de higienização de superfícies em aço inoxidável dos tanques de transporte de leite cru, de estocagem de leite cru resfriado, de equilíbrio de um pasteurizador

  18. Standard Operating Procedure (United States)


    l^m .:#,"■• y’’:>’£l’S ABO GROUP CONFIRMED |[ Rh OF .NEGATIVE UNITS CONFIRMED fe^/w’H’o’^Ä^ ■ •:.■.■:•• •■’ .Tv-v^l^.>’-V.^^V’ir;i-.^K-V.^’vV-i...using 0.02 ml of whole blood diluted with 5.98 ml of Drabkin’s reagent (1:251 dilution). 51 I. Measure the supernatant hemoglobin concentration...34NcUiod fef*ɜ 17-0? STANDARD OPERATING PROCEDURE Red Blood Cells Collected in the CPDA-1 800 ml Primary PVC Plastic Bag Collection System and

  19. 76 FR 16726 - Foreign-Trade Zone 41-Milwaukee, WI; Application for Reorganization Under Alternative Site Framework (United States)


    ... the zone under the alternative site framework (ASF) adopted by the Board (74 FR 1170, 1/ 12/09 (correction 74 FR 3987, 1/22/09); 75 FR 71069-71070, 11/22/10). The ASF is an option for grantees for the... was approved by the Board on September 29, 1978 (Board Order 136, 43 FR 46887, 10/11/1978)...

  20. Belief in the efficacy of alternative medicine among general practitioners in The Netherlands. (United States)

    Knipschild, P; Kleijnen, J; ter Riet, G


    A survey among 293 GPs in the Netherlands showed that many believe in the efficacy of common alternative procedures. High scores were especially found for manual therapy, yoga, acupuncture, hot bath therapy and homoeopathy. Other procedures, such as iridology, faith healing and many food supplements, were considered less useful.