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Sample records for alternative design solutions

  1. Beyond Fullerenes: Designing Alternative Molecular Electron Acceptors for Solution-Processable Bulk Heterojunction Organic Photovoltaics.

    Science.gov (United States)

    Sauvé, Geneviève; Fernando, Roshan

    2015-09-17

    Organic photovoltaics (OPVs) are promising candidates for providing a low cost, widespread energy source by converting sunlight into electricity. Solution-processable active layers have predominantly consisted of a conjugated polymer donor blended with a fullerene derivative as the acceptor. Although fullerene derivatives have been the acceptor of choice, they have drawbacks such as weak visible light absorption and poor energy tuning that limit overall efficiencies. This has recently fueled new research to explore alternative acceptors that would overcome those limitations. During this exploration, one question arises: what are the important design principles for developing nonfullerene acceptors? It is generally accepted that acceptors should have high electron affinity, electron mobility, and absorption coefficient in the visible and near-IR region of the spectra. In this Perspective, we argue that alternative molecular acceptors, when blended with a conjugated polymer donor, should also have large nonplanar structures to promote nanoscale phase separation, charge separation and charge transport in blend films. Additionally, new material design should address the low dielectric constant of organic semiconductors that have so far limited their widespread application.

  2. LCA to choose among alternative design solutions: the case study of a new Italian incineration line.

    Science.gov (United States)

    Scipioni, A; Mazzi, A; Niero, M; Boatto, T

    2009-09-01

    At international level LCA is being increasingly used to objectively evaluate the performances of different Municipal Solid Waste (MSW) management solutions. One of the more important waste management options concerns MSW incineration. LCA is usually applied to existing incineration plants. In this study LCA methodology was applied to a new Italian incineration line, to facilitate the prediction, during the design phase, of its potential environmental impacts in terms of damage to human health, ecosystem quality and consumption of resources. The aim of the study was to analyse three different design alternatives: an incineration system with dry flue gas cleaning (without- and with-energy recovery) and one with wet flue gas cleaning. The last two technological solutions both incorporating facilities for energy recovery were compared. From the results of the study, the system with energy recovery and dry flue gas cleaning revealed lower environmental impacts in relation to the ecosystem quality. As LCA results are greatly affected by uncertainties of different types, the second part of the work provides for an uncertainty analysis aimed at detecting the extent output data from life cycle analysis are influenced by uncertainty of input data, and employs both qualitative (pedigree matrix) and quantitative methods (Monte Carlo analysis).

  3. Seal design alternatives study

    Energy Technology Data Exchange (ETDEWEB)

    Van Sambeek, L.L. [RE/SPEC Inc., Rapid City, SD (US); Luo, D.D.; Lin, M.S.; Ostrowski, W.; Oyenuga, D. [Parsons Brinckerhoff Quade & Douglas, Inc., San Francisco, CA (US)

    1993-06-01

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information.

  4. ALTERNATIVE PROFESSIONAL TRAINING USING IT SOLUTIONS

    Directory of Open Access Journals (Sweden)

    EDUARD EDELHAUSER

    2012-10-01

    Full Text Available In the current economic context of Romania and especially in the difficult situation that mining areas are faced with, University of Petroşani aims to represent a powerful center for improvement, continuous training and reconversion of the labor force in these four counties. The project "Alternative professional training using IT solutions - a solution for reconversion of the labor force in the mining industry" could represent a solution, by developing modern and innovative methods of training based on an eLearning platform containing eight courses in a multimedia format. One of the professional training programs designed for qualify postgraduate unemployed persons is the IT consultant course. For collecting information that spot the training courses needs and competences we designed a questionnaire and distributed it to a number of employers, chosen as being the most significant within the prevailingly mining mono-industrial regions. The final solution is a portal designed on a tree structure basis. The technical solution proposed for designing the http://7.upet.ro/ portal was to use a Content Management System. We also used Info Path to design structured teaching scenario (teaching activities and Edu Integrator to create reusable learning objects, and consequently the eContent for the IT consultant course, and the eLearning platform.

  5. Enhanced Design Alternative IV

    Energy Technology Data Exchange (ETDEWEB)

    N. E. Kramer

    1999-05-18

    This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the ''Design Input Request for LADS Phase II EDA Evaluations'' (CRWMS M&O 1999b) and (CRWMS M&O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as ''line load''. Continuous pre-closure ventilation keeps the waste packages from exceeding the 350 C cladding and 200 C (4.3.13) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and a drip shields will be emplaced at closure to improve post-closure performance.

  6. New design of electric double layer capacitors with aqueous LiOH electrolyte as alternative to capacitor with KOH solution

    Science.gov (United States)

    Stepniak, Izabela; Ciszewski, Aleksander

    Activated carbon (AC) fiber cloths and a hydrophobic microporous polypropylene (PP) membrane, both modified with lithiated acetone oligomers, were used as electrodes and a separator in electric double layer capacitors (EDLCs) with aqueous lithium hydroxide (LiOH) as the electrolyte. Electrochemical characteristics of EDLCs were investigated by cyclic voltammetry (CV), galvanostatic charge-discharge cycle tests and impedance spectroscopy (EIS), compared with a case of the capacitor with aqueous potassium hydroxide (KOH) as an electrolyte. As a result, the capacitor with LiOH aqueous solution and a modified separator and electrodes was found to exhibit higher specific capacitance, maximum energy stored and maximum power than that with KOH aqueous solution.

  7. XML problem, design, solution

    CERN Document Server

    Amiano, Mitch; Ethier, Kay; Thomas, Michael D

    2006-01-01

    Offering a unique approach to learning XML, this book walks readers through the process of building a complete, functional, end-to-end XML solutionFeatured case study is an online business product catalog that includes reports, data input/output, workflow, stylesheet formatting, RSS feeds, and integration with external services like Google, eBay, and AmazonThe format of presenting a problem and working through the design to come up with a solution enables readers to understand how XML markup allows a business to share data across applications internally or with partners or customers even thoug

  8. Alternative Design of Boat Fenders

    DEFF Research Database (Denmark)

    Banke, Lars

    1996-01-01

    On offshore platforms the purpose of fenders is to protect the oil-risers against minor accidental collisions with supply vessels. Normally, the fender is designed by use of thin-walled tubes. However, the tube itself is not capable of resisting the impact load of the boat. Therefore, alternative...

  9. Designing Healthcare Solutions

    Directory of Open Access Journals (Sweden)

    Devorah E. Klein

    2009-11-01

    Full Text Available Innovation is generated when designers collaborate with scientists and clinicians. Who are designers? Professionals trained to uncover people’s spoken and unspoken needs (human factors researchers, to generate tangible products and services that address these needs in new and better ways (industrial and graphic designers, and to ensure that the design intent is preserved in the final manufactured form (engineers.

  10. Design rules for Microfactory Solutions

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Eriksson, Torbjörn Gerhard; Arentoft, Mogens;

    2006-01-01

    The current paper will present a classification of issues in microfactory design and setup and present examples of specific microfactory solutions developed at the authors' university.......The current paper will present a classification of issues in microfactory design and setup and present examples of specific microfactory solutions developed at the authors' university....

  11. Interior Design: Challenges and Solutions.

    Science.gov (United States)

    School Planning and Management, 1999

    1999-01-01

    Presents solutions to architectural challenges in school interior design; these solutions made the indoor environments more conducive and attractive for learning. Addresses four challenges: making a long corridor look less like a tunnel; maintaining tradition and minimizing cost in a new athletic facility; designing a kindergarten that is secure…

  12. Interior Design: Challenges and Solutions.

    Science.gov (United States)

    School Planning and Management, 1999

    1999-01-01

    Presents solutions to architectural challenges in school interior design; these solutions made the indoor environments more conducive and attractive for learning. Addresses four challenges: making a long corridor look less like a tunnel; maintaining tradition and minimizing cost in a new athletic facility; designing a kindergarten that is secure…

  13. Solution Prototyping with Design Thinking

    DEFF Research Database (Denmark)

    Efeoglu, Arkin; Møller, Charles; Serie, Michel

    2014-01-01

    are tried to be broken and Design Thinking advantages are increasingly preferred by man- agement. This case study based paper provides key insights into how DT phases and behavior can be changed for creating synergy across employees, manage- ment and products from which the end-consumer benefits. The Social...... Media for SAP store case study combines a conceptual and product oriented solution deri- vation with Design Thinking....

  14. Solution Prototyping with Design Thinking

    DEFF Research Database (Denmark)

    Efeoglu, Arkin; Møller, Charles; Serie, Michel

    are tried to be broken and Design Thinking advantages are increasingly preferred by man- agement. This case study based paper provides key insights into how DT phases and behavior can be changed for creating synergy across employees, manage- ment and products from which the end-consumer benefits. The Social...... Media for SAP store case study combines a conceptual and product oriented solution deri- vation with Design Thinking....

  15. Solution Prototyping with Design Thinking

    DEFF Research Database (Denmark)

    Efeoglu, Arkin; Møller, Charles; Serie, Michel

    are tried to be broken and Design Thinking advantages are increasingly preferred by man- agement. This case study based paper provides key insights into how DT phases and behavior can be changed for creating synergy across employees, manage- ment and products from which the end-consumer benefits. The Social...... Media for SAP store case study combines a conceptual and product oriented solution deri- vation with Design Thinking....

  16. Alternate powers in Serrin's swirling vortex solutions

    CERN Document Server

    Bělík, Pavel; Scholz, Kurt; Shvartsman, Mikhail M

    2012-01-01

    We consider a modification of the fluid flow model for a swirling vortex developed by J. Serrin, where velocity decreases as the reciprocal of the distance from the vortex axis. Recent studies, based on radar data of selected severe weather events, indicate that the angular momentum in a tornado may not be constant with the radius, and thus suggest a different scaling of the velocity/radial distance dependence. Motivated by this suggestion, we consider Serrin's approach with the assumption that the velocity decreases as the reciprocal of the distance from the vortex axis to the power b with a general b>0. This leads to a boundary-value problem for a system of nonlinear differential equations. We analyze this problem for particular cases, both with nonzero and zero viscosity, discuss the question of existence of solutions, and use numerical techniques to describe those solutions that we cannot obtain analytically.

  17. Silverlight 4 Problem - Design - Solution

    CERN Document Server

    Lecrenski, Nick

    2010-01-01

    A hands-on guide to Microsoft's latest rich application development technology: Silverlight 4. Silverlight 4 is the newest version of the rich Internet application toolkit that provides support for .NET capabilities over the Internet. With this latest release of Silverlight, Microsoft has revolutionized the way that Web applications can be created. This book uses the popular Problem – DesignSolution strategy to demonstrate how to harness the power and abilities of Silverlight 4 to add value to the overall user experience of a Web site. Using a Web site created by the author as a reference p

  18. Alternative Design of Postgraduate English Writing Course

    Institute of Scientific and Technical Information of China (English)

    王芬

    2008-01-01

    This paper presents an alternative design of postgraduate English writing course to meet the requirement of the current postgraduate English teaching reform.The author believes that efficiently-organized writing activities based on practical needs could refresh teaching frame- work and consequently assist postgraduates in English writing.

  19. Alternative design of the CLIC Damping Ring Lattice

    CERN Document Server

    Braun, Hans; Papaphilippou, Yannis; Siniatkin, Sergei; Zolotarev, Konstantin

    2010-01-01

    An original design of the CLIC damping ring demonstrates the parameters required for the linear collider together with the highly compact lattice (the circumference of the ring is only about 365 m). However, this design can hardly be implemented in a real machine because of such drawbacks as the lack of space between the magnetic elements to accommodate other accelerator components, serious problems with the evacuation of the high radiation power from damping wigglers and strong gradient of quadrupoles and sextupoles, which can hardly be achieved in the frame of the existing magnet technology. From this point of view this design can be considered as an ideal solution and an aim to be approached. In this paper we explore a possibility to design alternative solutions although with a larger size but with the same performance and with the realistic technical parameters.

  20. Mobilizing the Courage to Implement Sustainable Design Solutions

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Hoffmann, Birgitte; Quitzau, Maj-Britt

    2009-01-01

    Within the built environment, stakeholders tend to implement well-known design solutions, even though sustainable alternatives exist. The key question posed in this paper is: what characterizes successful processes of implementing sustainable design solutions? In an attempt to answer the question...... to ensure consideration of sustainable design criteria in the early phases of building projects. In the first case, the public authority succeeds in supporting design managers and other stakeholders to implement sustainable design solutions; in the second case, establishment of new multidisciplinary...... networks and creative work forms constitutes the outset for change. The work is inspired by the actor-network theory, emphasizing the momentum of prevailing practices, and the need to (re)develop networks to support implementation of sustainable design solutions. Conclusions point to the importance...

  1. Mobilizing the Courage to Implement Sustainable Design Solutions

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Hoffmann, Birgitte; Quitzau, Maj-Britt

    2009-01-01

    networks and creative work forms constitutes the outset for change. The work is inspired by the actor-network theory, emphasizing the momentum of prevailing practices, and the need to (re)develop networks to support implementation of sustainable design solutions. Conclusions point to the importance...... of design managers and others to develop socio-technical networks and storylines to integrate sustainability in the design and building processes. Implementation of sustainable design solutions takes more than courage; it requires key competences in catalysing network changes.......Within the built environment, stakeholders tend to implement well-known design solutions, even though sustainable alternatives exist. The key question posed in this paper is: what characterizes successful processes of implementing sustainable design solutions? In an attempt to answer the question...

  2. Design of Uranium Solution Critical Experimental Device

    Institute of Scientific and Technical Information of China (English)

    YI; Da-yong; GUO; Zhi-jia; YAO; Cheng-zhi; SHI; Chen-lei

    2012-01-01

    <正>In 2012, Department of reactor engineering design completes the design and mechanical analysis of Uranium solution critical experimental device. According to user’s requirements and nuclear safety regulations, design and analysis mainly involves two sets of core structure, uranium solution loop, water loop and experimental bench, etc. The core which includes a core vessel, reactor core support, safety rods, control rods, and so on, is used for containing uranium solution and fuel element and fulfilling the

  3. Refuge alternatives relief valve testing and design.

    Science.gov (United States)

    Lutz, T J; Bissert, P T; Homce, G T; Yonkey, J A

    2016-10-01

    The U.S. National Institute for Occupational Safety and Health (NIOSH) has been researching refuge alternatives (RAs) since 2007. RAs typically have built-in pressure relief valves (PRVs) to prevent the unit from reaching unsafe pressures. The U.S. Mine Safety and Health Administration requires that these valves vent the chamber at a maximum pressure of 1.25 kPa (0.18 psi, 5.0 in. H2O), or as specified by the manufacturer, above mine atmospheric pressure in the RA. To facilitate PRV testing, an instrumented benchtop test fixture was developed using an off-the-shelf centrifugal blower and ductwork. Relief pressures and flow characteristics were measured for three units: (1) a modified polyvinyl chloride check valve, (2) an off-the-shelf brass/cast-iron butterfly check valve and (3) a commercially available valve that was designed specifically for one manufacturer's steel prefabricated RAs and had been adapted for use in one mine operator's built-in-place RA. PRVs used in tent-style RAs were not investigated. The units were tested with different modifications and configurations in order to check compliance with Title 30 Code of Federal Regulations, or 30 CFR, regulations. The commercially available relief valve did not meet the 30 CFR relief pressure specification but may meet the manufacturer's specification. Alternative valve designs were modified to meet the 30 CFR relief pressure specification, but all valve designs will need further design research to examine survivability in the event of a 103 kPa (15.0 psi) impulse overpressure during a disaster.

  4. Designing Hyper-V solutions

    CERN Document Server

    Grover, Saurabh

    2015-01-01

    This book is aimed at IT admins, consultants, and architects alike who wish to deploy, manage, and maintain Hyper-V solutions in organizations of various sizes. You are expected to have a working knowledge of managing Windows Server and a fair understanding of networking and storage concepts.

  5. Alternative solutions for public and private catastrophe funding in Austria

    Directory of Open Access Journals (Sweden)

    M. Gruber

    2008-07-01

    Full Text Available The impacts of natural hazards as well as their frequency of occurrence during the last decades have increased decisively. Therefore, the public as well as the private sector are expected to react to this development by providing sufficient funds, in particular for the improvement of protection measures and an enhanced funding of damage compensation for affected private individuals, corporate and public entities.

    From the public stance, the establishment of an appropriate regulatory environment seems to be indispensable. Structural and legal changes should, on the one hand, renew and improve the current distribution system of public catastrophe funds as well as the profitable investment of these financial resources, and on the other hand, facilitate the application of alternative mechanisms provided by the capital and insurance markets.

    In particular, capital markets have developed alternative risk transfer and financing mechanisms, such as captive insurance companies, risk pooling, contingent capital solutions, multi-trigger products and insurance securitisation for hard insurance market phases. These instruments have already been applied to catastrophic (re-insurance in other countries (mainly the US and off-shore domiciles, and may contribute positively to the insurability of extreme weather events in Austria by enhancing financial capacities. Not only private individuals and corporate entities may use alternative mechanisms in order to retain, thus, to finance certain risks, but also public institutions.

    This contribution aims at analysing potential solutions for an improved risk management of natural hazards in the private and the public sector by considering alternative mechanisms of the capital and insurance markets. Also the establishment of public-private-partnerships, which may contribute to a more efficient cat funding system in Austria, is considered.

  6. Alternative solutions for public and private catastrophe funding in Austria

    Science.gov (United States)

    Gruber, M.

    2008-07-01

    The impacts of natural hazards as well as their frequency of occurrence during the last decades have increased decisively. Therefore, the public as well as the private sector are expected to react to this development by providing sufficient funds, in particular for the improvement of protection measures and an enhanced funding of damage compensation for affected private individuals, corporate and public entities. From the public stance, the establishment of an appropriate regulatory environment seems to be indispensable. Structural and legal changes should, on the one hand, renew and improve the current distribution system of public catastrophe funds as well as the profitable investment of these financial resources, and on the other hand, facilitate the application of alternative mechanisms provided by the capital and insurance markets. In particular, capital markets have developed alternative risk transfer and financing mechanisms, such as captive insurance companies, risk pooling, contingent capital solutions, multi-trigger products and insurance securitisation for hard insurance market phases. These instruments have already been applied to catastrophic (re-)insurance in other countries (mainly the US and off-shore domiciles), and may contribute positively to the insurability of extreme weather events in Austria by enhancing financial capacities. Not only private individuals and corporate entities may use alternative mechanisms in order to retain, thus, to finance certain risks, but also public institutions. This contribution aims at analysing potential solutions for an improved risk management of natural hazards in the private and the public sector by considering alternative mechanisms of the capital and insurance markets. Also the establishment of public-private-partnerships, which may contribute to a more efficient cat funding system in Austria, is considered.

  7. Engineering report (conceptual design) PFP solution stabilization

    Energy Technology Data Exchange (ETDEWEB)

    Witt, J.B.

    1997-07-17

    This Engineering Report (Conceptual Design) addresses remediation of the plutonium-bearing solutions currently in inventory at the Plutonium Finishing Plant (PFP). The recommendation from the Environmental Impact Statement (EIS) is that the solutions be treated thermally and stabilized as a solid for long term storage. For solutions which are not discardable, the baseline plan is to utilize a denitration process to stabilize the solutions prior to packaging for storage.

  8. International Companies Withdrawal from Lithuania: Problematics and Alternative Solutions

    Directory of Open Access Journals (Sweden)

    Viktorija Tauraitė

    2017-06-01

    Full Text Available The main attention in this article is focused on the problematic of international companies’ withdrawal from Lithuania and presentation of alternative solutions of this problem. The macro(Sweden, Austria, Latvia, Lithuania, Estonia, Poland level analysis and micro (“Coca-Cola”, “Nordea” and DNB, “Orkla” level analysis showed that competitiveness, business conditions, employment relations, institutional environment and innovation should be improved and the corruption should be reduced in Lithuania. It is advisable that current Lithuanian Labour Code should be revised in order to increase the efficiency of labour relations. It is found out that the significance of “Coca-Cola”company is the highest in the context of the withdrawing companies from Lithuania. It is assumed that the most rational solution for each company is to move from Lithuania to another country.

  9. Demand Response an Alternative Solution to Prevent Load Shedding Triggering

    Directory of Open Access Journals (Sweden)

    K. Mollah

    2014-12-01

    Full Text Available This paper investigates an alternative solution to prevent Load Shedding (LS triggering during underfrequency and proposes a new technique to restore the frequency during emergency events. Demand response (DR is considered as one of the most promising Smart Grid concepts that can be used to support the peak demand, whereas, LS is an existing last resort method during emergency grid situations. Both schemes aim to balance the load and generation in real-time and restore the frequency very quickly. This paper incorporates integrating Incentive based Demand Response (IDR with spinning reserve for smaller underfrequency events to manage the system peak demand. It also introduces a new frequency band for an Emergency Demand Response (EDR as an alternative inexpensive solution that can replace costly spinning reserves and help to prevent LS. An energy index factor is used to identify the consumption pattern of consumers to enable them to participate in IDR. An illustrative example of the performance of the proposed scheme on a modified 15 bus test system is shown. Simulation results on different scenarios confirm that the proposed method is effective to improve the frequency restoration process along with enabling participation of new services.

  10. Mobilizing the Courage to Implement Sustainable Design Solutions: Danish Experiences

    Directory of Open Access Journals (Sweden)

    Susanne Balslev Nielsen

    2009-12-01

    Full Text Available Within the built environment, stakeholders tend to implement well-known design solutions, even though sustainable alternatives exist. The key question posed in this paper is: what characterizes successful processes of implementing sustainable design solutions? In an attempt to answer the question, the work focuses on examples of successful implementation in an attempt to understand the competences required. Danish frontrunner projects are described and analysed: one case concerns the implementation of lowenergy houses and another describes innovative planning processes in the water sector in order to ensure consideration of sustainable design criteria in the early phases of building projects. In the first case, the public authority succeeds in supporting design managers and other stakeholders to implement sustainable design solutions; in the second case, establishment of new multidisciplinary networks and creative work forms constitutes the outset for change. The work is inspired by the actor-network theory, emphasizing the momentum of prevailing practices, and the need to (redevelop networks to support implementation of sustainable design solutions. Conclusions point to the importance of design managers and others to develop socio-technical networks and storylines to integrate sustainability in the design and building processes. Implementation of sustainable design solutions takes more than courage; it requires key competences in catalysing network changes DOI: 10.3763/aedm.2009.0906 Published in the Journal AEDM - Volume 5, Number 1, 2009 , pp. 53-61(9

  11. ADVANCED DESIGN SOLUTIONS FOR HIGH-PRECISION WOODWORKING MACHINES

    Directory of Open Access Journals (Sweden)

    Giuseppe Lucisano

    2016-03-01

    Full Text Available With the aim at performing the highest precision during woodworking, a mix of alternative approaches, fruitfully integrated in a common design strategy, is essential. This paper represents an overview of technical solutions, recently developed by authors, in design of machine tools and their final effects on manufacturing. The most advanced solutions in machine design are reported side by side with common practices or little everyday expedients. These design actions are directly or indirectly related to the rational use of materials, sometimes very uncommon, as in the case of magnetorheological fluids chosen to implement an active control in speed and force on the electro-spindle, and permitting to improve the quality of wood machining. Other actions are less unusual, as in the case of the adoption of innovative anti-vibration supports for basement. Tradition or innovation, all these technical solutions contribute to the final result: the highest precision in wood machining.

  12. Deferring Elimination of Design Alternatives in Object Oriented Methods

    NARCIS (Netherlands)

    Aksit, Mehmet; Marcelloni, Francesco

    2001-01-01

    While developing systems, software engineers generally have to deal with a large number of design alternatives. Current object-oriented methods aim to eliminate design alternatives whenever they are generated. Alternatives, however, should be eliminated only when sufficient information to take such

  13. Creating An Alternative Design for Asita Corporate Identity

    Directory of Open Access Journals (Sweden)

    Michelle Elise

    2015-10-01

    Full Text Available The objective of the study is to find the solution to the problem outlined, which is to create an alternative design for corporate identity of ASITA. ASITA is a non-profit organization to foster tours and travel agencies in Indonesia. The writer conducted interview to the ASITA Jakarta Chapter, which was appointed to represent ASITA in providing the data needed by the writer. The writer interviewed the advisor of the organization, which had once served as chairperson of ASITA. The result of the research is new corporate identity system of ASITA based on a concept that ASITA as an organization, serves as a compass that guides and assists in every direction. The writer found that corporate identity is an important element to define an organization as well as giving impact on its first impression. To create good corporate identity, several things such as elements of design, color, typography, etc need to be put into attention. 

  14. Creating an alternative design for ASITA Corporate identity

    Directory of Open Access Journals (Sweden)

    Michelle Elise

    2015-11-01

    Full Text Available The objective of the study is to find the solution to the problem outlined,which is to create an alternative design for corporate identity of ASITA. ASITA is anonprofit organization to foster tour and travel agencies in Indonesia.The writer had conducted interview to the ASITA Jakarta Chapter, whichwas appointed to represent ASITA in providing the data needed by the writer. Thewriter interviewed the advisor of the organization, Mrs. Meity Robot, which had onceserved as chairperson of ASITA.The result of the research is new corporate identity system of ASITA basedon a concept that ASITA as an organization, serves as a compass that guides andassists in every directions.The writer found that corporate identity is an important element to definean organization as well as giving impact on its first impression. To create goodcorporate identity, several things such as elements of design, color, typography, etc.need to be put into attention.

  15. The effect of the alternative solutions to formaldehyde and xylene on tissue processing

    Directory of Open Access Journals (Sweden)

    Ilgin Aydin

    2013-01-01

    Full Text Available Introduction and Aim: To assess the impact of new alternative solutions to formaldehyde and xylene on tissue processing, 13 different tissue processings were designed and performed on thirteen different tissues by using five different fixatives (formaldehyde, Glyo-Fixx® , FineFix® , Cell-block® , Green-Fix® and four different clearing agents (xylene, Sub-X® , Bio-clear® , Shandon Xylene Substitute® . Materials and Methods: Hematoxylin and Eosine stained sections were compared by using qualitative histomorphological criterions. Histochemical and immunohistochemical (IHC staining results were compared with qualitative and quantitative data obtained by a computer program, respectively. Tissue sections were tested for the availability of chromogenic in situ hybridization, deoxyribonucleic acid (DNA and ribonucleic acid (RNA extraction, and DNA quality by polymerase chain reaction. Results: The quality of sections was well for all tissue processings. All alternative solutions were suitable for histochemistry. IHC staining results showed that alternative solutions that contain glyoxal as active agent need optimization for this application. The clearance of signals with chromogenic in situ hybridization were nearly same and well for all tissue samples. Furthermore, tissue processes that do not contain formaldehyde were found to be superior on preservation of nucleic acids. Conclusion: Formaldehyde-free fixatives and alternative clearing agents have potential in routine pathology and research to replace formaldehyde and xylene.

  16. Optimality criteria solution strategies in multiple constraint design optimization

    Science.gov (United States)

    Levy, R.; Parzynski, W.

    1981-01-01

    Procedures and solution strategies are described to solve the conventional structural optimization problem using the Lagrange multiplier technique. The multipliers, obtained through solution of an auxiliary nonlinear optimization problem, lead to optimality criteria to determine the design variables. It is shown that this procedure is essentially equivalent to an alternative formulation using a dual method Lagrangian function objective. Although mathematical formulations are straight-forward, successful applications and computational efficiency depend upon execution procedure strategies. Strategies examined, with application examples, include selection of active constraints, move limits, line search procedures, and side constraint boundaries.

  17. Creating by Reusing Learning Design Solutions

    NARCIS (Netherlands)

    Hernández-Leo, Davinia; Harrer, Andreas; Dodero, Juan Manuel; Asensio-Pérez, Juan; Burgos, Daniel

    2006-01-01

    Hernández-Leo, D., Harrer, A., Dodero, J. M., Asension-Pérez, J. I., & Burgos, D. (2006). Creating by reusing Learning Design solutions. Proceedings of 8th Simposo Internacional de Informática Educativa, León, Spain: IEEE Technical Committee on Learning Technology. Retrieved October 3rd, 2006, from

  18. Digital Hardware Design Teaching: An Alternative Approach

    Science.gov (United States)

    Benkrid, Khaled; Clayton, Thomas

    2012-01-01

    This article presents the design and implementation of a complete review of undergraduate digital hardware design teaching in the School of Engineering at the University of Edinburgh. Four guiding principles have been used in this exercise: learning-outcome driven teaching, deep learning, affordability, and flexibility. This has identified…

  19. Digital Hardware Design Teaching: An Alternative Approach

    Science.gov (United States)

    Benkrid, Khaled; Clayton, Thomas

    2012-01-01

    This article presents the design and implementation of a complete review of undergraduate digital hardware design teaching in the School of Engineering at the University of Edinburgh. Four guiding principles have been used in this exercise: learning-outcome driven teaching, deep learning, affordability, and flexibility. This has identified…

  20. Alternating phase-shifted mask for logic gate levels, design, and mask manufacturing

    Science.gov (United States)

    Liebmann, Lars W.; Graur, Ioana C.; Leipold, William C.; Oberschmidt, James M.; O'Grady, David S.; Regaill, Denis

    1999-07-01

    While the benefits of alternating phase shifted masks in improving lithographic process windows at increased resolution are well known throughout the lithography community, broad implementation of this potentially powerful technique has been slow due to the inherent complexity of the layout design and mask manufacturing process. This paper will review a project undertaken at IBM's Semiconductor Research and Development Center and Mask Manufacturing and Development facility to understand the technical and logistical issues associated with the application of alternating phase shifted mask technology to the gate level of a full microprocessor chip. The work presented here depicts an important milestone toward integration of alternating phase shifted masks into the manufacturing process by demonstrating an automated design solution and yielding a functional alternating phase shifted mask. The design conversion of the microprocessor gate level to a conjugate twin shifter alternating phase shift layout was accomplished with IBM's internal design system that automatically scaled the design, added required phase regions, and resolved phase conflicts. The subsequent fabrication of a nearly defect free phase shifted mask, as verified by SEM based die to die inspection, highlights the maturity of the alternating phase shifted mask manufacturing process in IBM's internal mask facility. Well defined and recognized challenges in mask inspection and repair remain and the layout of alternating phase shifted masks present a design and data preparation overhead, but the data presented here demonstrate the feasibility of designing and building manufacturing quality alternating phase shifted masks for the gate level of a microprocessor.

  1. Improved Paintball Design and Alternative Payloads

    Science.gov (United States)

    2006-11-01

    wavelengths depending on the size and composition of the quantum dots (Bruchez et al., 1998). Cadmium selenide and lead selenide nanoparticles of 2-9 nm...markers. A Canon EOS Rebel modified with an X-Nite filter that blocks wavelengths below 750 nm was used to capture photographs in the near IR...Obscurant Payloads Carbon black was dispersed fairly well into vegetable oil. However, the carbon black settles out of solution within a few minutes

  2. Designing oligo libraries taking alternative splicing into account

    Science.gov (United States)

    Shoshan, Avi; Grebinskiy, Vladimir; Magen, Avner; Scolnicov, Ariel; Fink, Eyal; Lehavi, David; Wasserman, Alon

    2001-06-01

    We have designed sequences for DNA microarrays and oligo libraries, taking alternative splicing into account. Alternative splicing is a common phenomenon, occurring in more than 25% of the human genes. In many cases, different splice variants have different functions, are expressed in different tissues or may indicate different stages of disease. When designing sequences for DNA microarrays or oligo libraries, it is very important to take into account the sequence information of all the mRNA transcripts. Therefore, when a gene has more than one transcript (as a result of alternative splicing, alternative promoter sites or alternative poly-adenylation sites), it is very important to take all of them into account in the design. We have used the LEADS transcriptome prediction system to cluster and assemble the human sequences in GenBank and design optimal oligonucleotides for all the human genes with a known mRNA sequence based on the LEADS predictions.

  3. Design of sustainable chemical processes: Systematic retrofit analysis, generation and evaluation alternatives

    DEFF Research Database (Denmark)

    Carvalho, Ana; Gani, Rafiqul; Matos, Henrique

    2008-01-01

    The objective of this paper is to present a generic and systematic methodology for identifying the feasible retrofit design alternatives of any chemical process. The methodology determines a set of mass and energy indicators from steady-state process data, establishes the operational and design...... targets, and through a sensitivity-based analysis, identifies the design alternatives that can match a set of design targets. The significance of this indicator-based method is that it is able to identify alternatives, where one or more performance criteria (factors) move in the same direction thereby...... eliminating the need to identify trade-off-based solutions. These indicators are also able to reduce (where feasible) a set of safety indicators. An indicator sensitivity analysis algorithm has been added to the methodology to define design targets and to generate sustainable process alternatives. A computer...

  4. On Alternative Optimal Solutions to Linear Fractional Optimization Problems

    Institute of Scientific and Technical Information of China (English)

    ShengjiaXue

    2004-01-01

    The structure of the optimal solution set is derived for linear fractional optimization problems with the representation theorem of polyhedral sets.And the computational procedure in determining all optimal solutions is also given.

  5. Alternative Solutions to Bianchi Type-Ⅰ Cosmology

    Institute of Scientific and Technical Information of China (English)

    YI Ying; LI Fang-Yu

    2007-01-01

    @@ We present a class of new exact solutions in string cosmology theory, and the solutions describe a homogeneous but anisotropic plane-symmetric string universe within the framework of Bianchi type-Ⅰ cosmology. Some solutions previously discussed are included in the class of exact solutions as the special cases. Our result may provide further quantitative description and theoretical basis for the string cosmology model.

  6. Towards for Analyzing Alternatives of Interaction Design Based on Verbal Decision Analysis of User Experience

    Directory of Open Access Journals (Sweden)

    Marília Soares Mendes

    2010-04-01

    Full Text Available In domains (as digital TV, smart home, and tangible interfaces that represent a new paradigm of interactivity, the decision of the most appropriate interaction design solution is a challenge. HCI researchers have promoted in their works the validation of design alternative solutions with users before producing the final solution. User experience with technology is a subject that has also gained ground in these works in order to analyze the appropriate solution(s. Following this concept, a study was accomplished under the objective of finding a better interaction solution for an application of mobile TV. Three executable applications of mobile TV prototypes were built. A Verbal Decision Analysis model was applied on the investigations for the favorite characteristics in each prototype based on the user’s experience and their intentions of use. This model led a performance of a qualitative analysis which objectified the design of a new prototype.

  7. ON ALTERNATIVE OPTIMAL SOLUTIONS TO QUASIMONOTONIC PROGRAMMING WITH LINEAR CONSTRAINTS

    Institute of Scientific and Technical Information of China (English)

    Xue Shengjia

    2007-01-01

    In this paper, the nonlinear programming problem with quasimonotonic ( both quasiconvex and quasiconcave )objective function and linear constraints is considered. With the decomposition theorem of polyhedral sets, the structure of optimal solution set for the programming problem is depicted. Based on a simplified version of the convex simplex method,the uniqueness condition of optimal solution and the computational procedures to determine all optimal solutions are given, if the uniqueness condition is not satisfied. An illustrative example is also presented.

  8. Environmental comparison of a railway bridge with alternative designs

    DEFF Research Database (Denmark)

    Du, Guangli; Karoumi, Raid

    2012-01-01

    for quantifying and assessing the environmental impacts of the products through its whole life cycle. This paper presents a comparative case study between two alternative designs of Banafjäl Bridge: ballast track design and fixed slab track design. The methodology of LCA is utilized as a supporting tool...

  9. A von Neumann Alternating Method for Finding Common Solutions to Variational Inequalities

    CERN Document Server

    Censor, Yair; Reich, Simeon

    2012-01-01

    Modifying von Neumann's alternating projections algorithm, we obtain an alternating method for solving the recently introduced Common Solutions to Variational Inequalities Problem (CSVIP). For simplicity, we mainly confine our attention to the two-set CSVIP, which entails finding common solutions to two unrelated variational inequalities in Hilbert space.

  10. Insights Gained from Testing Alternate Cell Designs

    Energy Technology Data Exchange (ETDEWEB)

    J. E. O' Brien; C. M. Stoots; J. S. Herring; G. K. Housley; M. S. Sohal; D. G. Milobar; Thomas Cable

    2009-09-01

    The Idaho National Laboratory (INL) has been researching the application of solid-oxide electrolysis cell for large-scale hydrogen production from steam over a temperature range of 800 to 900ºC. The INL has been testing various solid oxide cell designs to characterize their electrolytic performance operating in the electrolysis mode for hydrogen production. Some results presented in this report were obtained from cells, initially developed by the Forschungszentrum Jülich and now manufactured by the French ceramics firm St. Gobain. These cells have an active area of 16 cm2 per cell. They were initially developed as fuel cells, but are being tested as electrolytic cells in the INL test stands. The electrolysis cells are electrode-supported, with ~10 µm thick yttria-stabilized zirconia (YSZ) electrolytes, ~1400 µm thick nickel-YSZ steam-hydrogen electrodes, and manganite (LSM) air-oxygen electrodes. The experiments were performed over a range of steam inlet mole fractions (0.1 to 0.6), gas flow rates, and current densities (0 to 0.6 A/cm2). Steam consumption rates associated with electrolysis were measured directly using inlet and outlet dewpoint instrumentation. On a molar basis, the steam consumption rate is equal to the hydrogen production rate. Cell performance was evaluated by performing DC potential sweeps at 800, 850, and 900°C. The voltage-current characteristics are presented, along with values of area-specific resistance as a function of current density. Long-term cell performance is also assessed to evaluate cell degradation. Details of the custom single-cell test apparatus developed for these experiments are also presented. NASA, in conjunction with the University of Toledo, has developed another fuel cell concept with the goals of reduced weight and high power density. The NASA cell is structurally symmetrical, with both electrodes supporting the thin electrolyte and containing micro-channels for gas diffusion. This configuration is called a bi

  11. Comparison of different SFL design alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Ivars Neretnieks, Ivars [Chemima AB, Taeby (Sweden); Moreno, Luis [LMQuimica, Vaarby (Sweden)

    2013-04-15

    Four different design options for a repository for long-lived nuclear waste from the future dismantling of the nuclear power plants have been compared. The time scales considered range up to 100,000 years. The repository is to be located at about 500 m depth in granitic rock. The vault can be a tunnel about 200 m long and on the order of 15 X 15 meters, in which the waste is surrounded by either a hydraulic cage, a concrete buffer or a bentonite buffer about 2 m thick. A fourth option is to make a silo, called Supersilo, about as high as wide, surrounded by both concrete and bentonite. In order to compare potential release rates of radionuclides from the waste to the seeping water in the rock a number of simple models have been devised. Some of these models allow the water flow rates through vaults to be assessed under various conditions and configurations. Other models are used to calculate the uptake by molecular diffusion to the water in the rock that seeps past the vaults. Moreover other models are used to calculate the rate of transport of nuclides by diffusion and flow through the buffer and waste. The decay of the nuclides during their passage from the waste to the flowing water through and past the vaults is accounted for. Many nuclides of interest decay considerably in the buffer. The mathematical form of the models is made so simple that essentially hand calculations can be used to explore the strength of different barriers and design options. The simple models are validated against more complex coupled models accounting for simultaneously competing processes. The more complex models are solved by numerical methods. The toolbox of simple models is used to calculate the strength of the barriers in the different design options under various conditions. Examples of activity releases of three nuclides with different sorption characteristics and half-lives are presented. It is found that a hydraulic cage is not a good option as it promotes the release of

  12. Spontaneous Oligomerization of Nucleotide Alternatives in Aqueous Solutions

    Science.gov (United States)

    Smith, Karen E.; House, Christopher H.; Dworkin, Jason P.; Callahan, Michael P.

    2017-03-01

    On early Earth, a primitive polymer that could spontaneously form from likely available precursors may have preceded both RNA and DNA as the first genetic material. Here, we report that heated aqueous solutions containing 5-hydroxymethyluracil (HMU) result in oligomers of uracil, heated solutions containing 5-hydroxymethylcytosine (HMC) result in oligomers of cytosine, and heated solutions containing both HMU and HMC result in mixed oligomers of uracil and cytosine. Oligomerization of hydroxymethylated pyrimidines, which may have been abundant on the primitive Earth, might have been important in the development of simple informational polymers.

  13. 31 CFR 0.104 - Designated Agency Ethics Official and Alternate Designated Agency Ethics Official.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Designated Agency Ethics Official and Alternate Designated Agency Ethics Official. 0.104 Section 0.104 Money and Finance: Treasury Office of the... Responsibilities § 0.104 Designated Agency Ethics Official and Alternate Designated Agency Ethics Official....

  14. Alternatives for the disposition of PUREX organic solution

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, D.W.

    1995-06-16

    This Supporting Document submits options and recommendations for final management of Tank 40 Plutonium-Uranium Extraction (PUREX) Plant organic solution per Tri-Party Agreement Milestorm Number M-80-00-T03. Hanford is deactivating the PUREX Plant for the US DOE. One the key element of this Deactivation is disposition of approximately 81,300 liters (21,500 gallons) of slightly radioactively contaminated organic solution to reduce risk to the environment, reduce cost of long-term storage, and assure regulatory compliance. An announcement in the Commerce Business Daily (CBD) on October 14, 1994 has resulted in the submission of proposals from two facilities capabLe of receiving and thermally destroying the solution. Total decomposition by thermal destruction is the recommended option for the disposition of the PUREX organic solution and WHC is evaluating the proposals from the two facilities.

  15. Wireless device connection problems and design solutions

    Science.gov (United States)

    Song, Ji-Won; Norman, Donald; Nam, Tek-Jin; Qin, Shengfeng

    2016-09-01

    Users, especially the non-expert users, commonly experience problems when connecting multiple devices with interoperability. While studies on multiple device connections are mostly concentrated on spontaneous device association techniques with a focus on security aspects, the research on user interaction for device connection is still limited. More research into understanding people is needed for designers to devise usable techniques. This research applies the Research-through-Design method and studies the non-expert users' interactions in establishing wireless connections between devices. The "Learning from Examples" concept is adopted to develop a study focus line by learning from the expert users' interaction with devices. This focus line is then used for guiding researchers to explore the non-expert users' difficulties at each stage of the focus line. Finally, the Research-through-Design approach is used to understand the users' difficulties, gain insights to design problems and suggest usable solutions. When connecting a device, the user is required to manage not only the device's functionality but also the interaction between devices. Based on learning from failures, an important insight is found that the existing design approach to improve single-device interaction issues, such as improvements to graphical user interfaces or computer guidance, cannot help users to handle problems between multiple devices. This study finally proposes a desirable user-device interaction in which images of two devices function together with a system image to provide the user with feedback on the status of the connection, which allows them to infer any required actions.

  16. Nonrandom Assignment in ANCOVA: The Alternate Ranks Design

    Science.gov (United States)

    Dalton, Starrett; Overall, John E.

    1977-01-01

    A specific form of nonrandom assignment to treatment groups, the "alternate ranks" design, was investigated. This design eliminates the possibility of a correlation between the covariate and the treatment, and rules out experimenter bias in assignment of subjects to groups. (Editor)

  17. Schema Design Alternatives for Multi-Granular Data Warehousing

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem; Pedersen, Torben Bach

    2010-01-01

    that the schema designs are intended to simply store data at the same single level of granularity. This paper on the other hand, presents several extended dimensional data warehousing schema design alternatives to store both detail and aggregated data at different levels of granularity. The paper presents three...

  18. Design of a nonscaling fixed field alternating gradient accelerator

    CERN Document Server

    Trbojevic, D; Blaskiewicz, M

    2005-01-01

    We present a design of nonscaling fixed field alternating gradient accelerators (FFAG) minimizing the dispersion action function H. The design is considered both analytically and via computer modeling. We present the basic principles of a nonscaling FFAG lattice and discuss optimization strategies so that one can accelerate over a broad range of momentum with reasonable apertures. Acceleration schemes for muons are discussed.

  19. Design of a nonscaling fixed field alternating gradient accelerator

    Science.gov (United States)

    Trbojevic, D.; Courant, E. D.; Blaskiewicz, M.

    2005-05-01

    We present a design of nonscaling fixed field alternating gradient accelerators (FFAG) minimizing the dispersion action function H. The design is considered both analytically and via computer modeling. We present the basic principles of a nonscaling FFAG lattice and discuss optimization strategies so that one can accelerate over a broad range of momentum with reasonable apertures. Acceleration schemes for muons are discussed.

  20. Digital Rights Management - Promises, Problems and Alternative Solutions

    OpenAIRE

    Syversen, Kristian

    2004-01-01

    This thesis presents the introduction of Digital Rights Management (DRM) systems used to protect copyrighted content, why these systems are emphasized and by whom. Legal and technical aspects of such methods are also introduced. Moreover, progress in anti-piracy techniques and reasons for the current situation with online piracy are explained. In addition to presenting an alternative model for digital entertainment business, a new distribution system based on direct subscription on downloadab...

  1. Novel Design Solutions for Fishing Reel Mechanisms

    Institute of Scientific and Technical Information of China (English)

    LOVASZ Erwin-Christian; MODLER Karl-Heinz; NEUMANN Rudolf; GRUESCU Corina Mihaela; PERJU Dan; CIUPE Valentin; MANIU Inocentiu

    2015-01-01

    Currently, there are various reels on the market regarding the type of mechanism, which achieves the winding and unwinding of the line. The designers have the purpose of obtaining a linear transmission function, by means of a simple and small-sized mechanism. However, the present solutions are not satisfactory because of large deviations from linearity of the transmission function and complexity of mechanical schema. A novel solution for the reel spool mechanism is proposed. Its kinematic schema and synthesis method are described. The kinematic schema of the chosen mechanism is based on a noncircular gear in series with a scotch-yoke mechanism. The yoke is driven by a stud fixed on the driving noncircular gear. The drawbacks of other models regarding the effects occurring at the ends of the spool are eliminated through achieving an appropriate transmission function of the spool. The linear function approximation with curved end-arches appropriately computed to ensure mathematical continuity is very good. The experimental results on the mechanism model validate the theoretical approach. The developed mechanism solution is recorded under a reel spool mechanism patent.

  2. 29 CFR 2703.2 - Designated agency ethics official and alternate designated agency ethics official.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Designated agency ethics official and alternate designated agency ethics official. 2703.2 Section 2703.2 Labor Regulations Relating to Labor (Continued) FEDERAL... agency ethics official and alternate designated agency ethics official. The Chairman shall appoint...

  3. Valuation of flexible solutions with alternative fuel cell energy sources

    Energy Technology Data Exchange (ETDEWEB)

    Haahtela, T.; Surakka, T.; Malinen, P. [Helsinki Univ. of Technology, Espoo (Finland). BIT Research Centre

    2009-07-01

    Fuel cells are an emerging technology with high potential, but also with significant market uncertainty. Fuel cells are currently in the transition from field trials to commercial introduction, and firms need to consider whether the technology fulfils the reliability and cost requirements of their current and upcoming products. This paper presented a framework to assist managers in finding the suitable valuation method for comparing different alternatives with emerging fuel cell technology. The dynamic valuation approaches of decision tree analysis, real options and system dynamics were discussed as they help in choosing the optimal timing and product structure over a long time period. Three examples of applications with fuel cells were briefly presented. The paper also addressed how the suggested valuation methods could be applied to them. These applications included maritime buoys; removable crisis management energy source container; and electrification of public transportation. It was concluded that the fuel cell technology has already become economically feasible in certain application areas. Improving technical reliability and cost reductions will make fuel cells even more competitive alternatives in new application areas. 9 refs., 1 tab., 1 fig.

  4. Lightened plaster: alternative solutions to cellular solids addition

    Directory of Open Access Journals (Sweden)

    Del Río, M.

    2004-09-01

    Full Text Available The following paper pretends to analyze different processes in order to lightweighters gypsum as an alternative way at the cellular fillers addition, in order to establish the most suitable ones for the manufacture of plasterboard. Outstanding the process which uses foamings addition to lighten gypsum uses nowdays only to manufacture cellular concrete.

    En este artículo se presenta el análisis de diferentes procedimientos para aligerar la escayola, como alternativas a la adición de sólidos celulares, determinando los más adecuados para la realización de prefabricados. Dentro de estos procedimientos cabe destacar la adición de espumantes, hasta ahora sólo utilizados para la fabricación de hormigones celulares.

  5. Alternative solutions for inhibiting Legionella in domestic hot water systems based on low-temperature district heating

    DEFF Research Database (Denmark)

    Yang, Xiaochen; Li, Hongwei; Svendsen, Svend

    2015-01-01

    Abstract District heating is a cost-effective way of providing heat to high heat density areas. Low-temperature district heating (LTDH) is a promising way to make district heating more energy-efficient and adaptable to well-insulated buildings with low heating demand in the future. However, one....... The alternative design approach can eliminate the risk factors of Legionella by local temperature boosting and restricting system volume. Decentralized substations, micro heat pumps, electric heating elements and electric heat tracing are all investigated as alternative designs. With regard to sterilization...... systems. They have the additional benefit of reducing the heat loss of the hot water system. The alternative design solutions both enrich our options for water sanitation and improve the energy efficiency of our energy systems....

  6. Evaluation of HiPHES convective reformer design alternatives

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-01

    Phase I Stone Webster presented three potential design configurations for a ceramic-tubed steam-methane reformer. These were the Tube-Within-a-Tube (TWIT) design, the Once-Through design, and the Monolith design. Although the TWIT design configuration appeared to be the most viable, the inclusion of a more detailed examination of design alternatives for the HiPHES reformer was deemed appropriate for the Phase II program. Of particular concern was the length of the ceramic tubes required for the TWIT design. To assist in this evaluation, Stone Webster established a Development Team consisting of specialists in the areas of heat transfer, ceramic materials, exchanger design, vessel design, and potential users. Stone Webster reviewed the critical areas of concern for a ceramic convective reformer, evaluated competing design configurations, and presented the results to the Development Team. This report presents Stone Webster's evaluations and the comments and recommendations of the Development Team. This effort comprised the majority of Task 1 of Phase II of Stone Webster's HiPHES project. The design review was executed in parallel with the material coupon screening tests at BP America. The goal of both tasks was to confirm the materials selection and reformer design configuration so that the conditions for the tube and joint tests to be conducted at Oak Ridge National Laboratory (ORNL) could be specified. The ORNL tests are intended to evaluate the reformer design configuration and materials of construction used for the reformer design in Phase II, and to be used in the demonstration unit in Phase III. The Task 1 (Evaluation of Alternative Reformer Designs) effort has identified a preferred design configuration for the proposed ceramic reformer. Additional engineering and material evaluation work is necessary before an operating prototype can be designed.

  7. Alternative Data Storage Solution for Mobile Messaging Services

    Directory of Open Access Journals (Sweden)

    David C. C. Ong

    2007-01-01

    Full Text Available In recent years, mobile devices have become relatively more powerful with additional features which have the capability to provide multimedia streaming. Better, faster and more reliable data storage solutions in the mobile messaging platform have become more essential with these additional improvements. The existing mobile messaging infrastructure, in particular the data storage platform has become less proficient in coping with the increased demand for its services. This demand especially in the mobile messaging area (i.e. SMS – Short Messaging Service, MMS – Multimedia Messaging Service, which may well exceeded 250,000 requests per second, means that the need to evaluate competing data management systems has become not only necessary but essential. This paper presents an evaluation of SMS and MMS platforms using different database management systems – DBMS and recommends the best data management strategies for these platforms.

  8. An alternative tensiometer design for deep vadose zone monitoring

    Science.gov (United States)

    Moradi, A. B.; Kandelous, M. M.; Hopmans, J. W.

    2015-12-01

    The conventional tensiometer is among the most accurate devices for soil water matric potential measurements, as well as for estimations of soil water flux from soil water potential gradients. Uncertainties associated with conventional tensiometers such as caused by ambient temperature effects and the draining of the tensiometer tube, as well as their limitation for deep soil monitoring has prevented their widespread use for vadose zone monitoring, despite their superior accuracy, in general. We introduce an alternative tensiometer design that offers the accuracy of the conventional tensiometer, while minimizing afore-mentioned uncertainties and limitations. The proposed alternative tensiometer largely eliminates temperature-induced diurnal fluctuations and uncertainties associated with the draining of the tensiometer tube, and removes the limitation in installation depth. In addition, the manufacturing costs of this alternative tensiometer design is close to that of the conventional tensiometer, while it is especially suited for monitoring of soil water potential gradients as required for soil water flux measurements.

  9. Single-room occupancy hotels: possible solutions and alternatives.

    Science.gov (United States)

    Foley, D

    1998-09-01

    New York City's Division of AIDS Services and Income Support (DASIS) places clients in economical, commercial residences in one of 33 hotels in the New York City area, termed single-room occupancy (SRO) hotels. There have been many problems with these hotels in terms of safety and health. One problem is how to enforce housing laws when city agencies have had drastic personnel cutbacks, and landlords are not held accountable for repairs and building conditions. Without a strategic plan to supplement SROs with necessary services, and a way to deal with homeless people with AIDS, it will be difficult to redeem the condition of SROs and lessen dependency on them as a long-term solution. The West Side SRO Law Project offers tips on how tenants in SROs can safeguard their rights and document their cases if they feel that their rights have been violated. Included is a resource list for legal help and emergency numbers for the Department of Buildings in New York City and the surrounding boroughs.

  10. Alternate Design of ITER Cryostat Skirt Support System

    Science.gov (United States)

    Pandey, Manish Kumar; Jha, Saroj Kumar; Gupta, Girish Kumar; Bhattacharya, Avik; Jogi, Gaurav; Bhardwaj, Anil Kumar

    2017-04-01

    The skirt support of ITER cryostat is a support system which takes all the load of cryostat cylinder and dome during normal and operational condition. The present design of skirt support has full penetration weld joints at the bottom (shell to horizontal plate joint). To fulfil the requirements of tolerances and control the welding distortions, we have proposed to change the full penetration weld into fillet weld. A detail calculation is done to check the feasibility and structural impact due to proposed design. The calculations provide the size requirements of fillet weld. To verify the structural integrity during most severe load case, finite element analysis (FEA) has been done in line with ASME section VIII division 2 [1]. By FEA ‘Plastic Collapse’ and ‘Local Failure’ modes has been assessed. 5° sector of skirt clamp has been modelled in CATIA V5 R21 and used in FEA. Fillet weld at shell to horizontal plate joint has been modelled and symmetry boundary condition at ± 2.5° applied. ‘Elastic Plastic Analysis’ has been performed for the most severe loading case i.e. Category IV loading. The alternate design of Cryostat Skirt support system has been found safe by analysis against Plastic collapse and Local Failure Modes with load proportionality factor 2.3. Alternate design of Cryostat skirt support system has been done and validated by FEA. As per alternate design, the proposal of fillet weld has been implemented in manufacturing.

  11. Designing Integrated Product- Service System Solutions in Manufacturing Industries

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2015-01-01

    Manufacturing firms are increasingly evolving towards the design of integrated product-service solutions but servitization literature does not provide specific guidance on how to design these integrated solutions. Building upon ProductService System (PSS) and Service Design (SD) approaches...... how it brings new insights to manufacturing companies moving to a service, value cocreation perspective....

  12. The challenges of heat sterilization of peritoneal dialysis solutions: is there an alternative?

    Science.gov (United States)

    Hanrahan, Conor T; Himmele, Rainer; Diaz-Buxo, Jose A

    2012-01-01

    Peritoneal dialysis (PD) solutions are currently sterilized in an autoclave using high-temperature saturated steam. Although thermal methods are an effective means of sterilization, the heating of PD solutions results in the formation of toxic glucose degradation products (GDPs). Here, we review basic concepts in the sterilization of PD solutions and discuss possible alternatives to steam sterilization, including filtration, ohmic heat, ionizing radiation, and pulsed ultraviolet light. Although the latter methods have several advantages, many also have prohibitive limitations or have not been adequately studied for use on PD solutions. Thus, in the absence of suitable alternatives, conventional heat sterilization, in combination with low-GDP manufacturing practices, remains the best option at the present time.

  13. Problem-oriented system solutions in the use of alternative energies

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, E.

    1982-01-01

    The share of alternative energies in the energy supply of the earth that is solar-, wind- and bio-energy will rise to about 20% within the next 50 years. Use of alternative energy on a large basis will, however, not take place in central power stations but in decentralised plants within the KW- and lower MW-range. Utilization of alternative energies demands individual solution for individual problems depending on the site and consumer-demands, and at this point they differ from conventional energy technology.

  14. A mathematical solution to a network designing problem.

    Science.gov (United States)

    Takahashi, Y

    1996-01-01

    One of the major open issues in neural network research includes a Network Designing Problem (NDP): find a polynomial-time procedure that produces minimal structures (the minimum intermediate size, thresholds and synapse weights) of multilayer threshold feed-forward networks so that they can yield outputs consistent with given sample sets of input-output data. The NDP includes as a subproblem a Network Training Problem (NTP) where the intermediate size is given. The NTP has been studied mainly by use of iterative algorithms of network training. This paper, making use of both rate distortion theory in information theory and linear algebra, solves the NDP mathematically rigorously. On the basis of this mathematical solution, it furthermore develops a mathematical solution procedure to the NDP that computes the minimal structure straightforwardly from the sample set. The procedure precisely attains the minimum intermediate size, although its computational time complexity can be of nonpolynomial order at worst cases. The paper also refers to a polynomial-time shortcut of the procedure for practical use that can reach an approximate minimum intermediate size with its error measurable. The shortcut, when the intermediate size is prespecified, reduces to a promising alternative as well to current network training algorithms to the NTP.

  15. LEO intermediary propagation as a feasible alternative to Brouwer's gravity solution

    OpenAIRE

    Lara, Martin

    2014-01-01

    The performance of Brouwer's gravity solution is compared with Deprit's second-order radial intermediary. Taking the main problem of the artificial satellite as the test model, that is perturbations are limited to the effects of the second zonal harmonic, it is demonstrated that the intermediary solution provides an efficient alternative for the analytical propagation of low earth orbits in a range determined by non-impact orbits with eccentricities below one tenth.

  16. LEO intermediary propagation as a feasible alternative to Brouwer's gravity solution

    Science.gov (United States)

    Lara, Martin

    2015-08-01

    The performance of Brouwer's gravity solution is compared with Deprit's second-order radial intermediary. Taking the main problem of the artificial satellite as the test model, that is perturbations are limited to the effects of the second zonal harmonic, it is demonstrated that the intermediary solution provides an efficient alternative for the analytical propagation of low earth orbits in a range determined by non-impact orbits with eccentricities below one tenth.

  17. An Alternative Algorithm for Optimal Design of Plate Heat Exchangers

    Directory of Open Access Journals (Sweden)

    Seyyed Morteza Javid

    2015-02-01

    Full Text Available Due to the complex geometry of plate heat exchangers and thus a large number of variables affecting the performance of the exchangers, the design of these types of exchangers is quiet difficult. However, unlike the shell and tube heat exchangers which contain available data of design procedures, the design of plate heat exchanger is a monopoly of some certain manufacturing companies that make the problem even worse. In this paper, the objective is to minimize the number of plates in plate heat exchanger; in order to achieve that, a simple and yet efficient mathematical model is introduced for determination of the pressure drop and heat capacity of a plate heat exchanger in single- and multipass state and also a program was defined for determination of optimal solution based on this simple mathematical model for given operational constraints and plate type. In the end, the optimal solution will be compared to the answer of CAS200 commercial software and also it is shown that the effect of the start and end plates and transverse distribution in optimal solution is considerable.

  18. Arizona Public Service - Alternative Fuel (Hydrogen) Pilot Plant Design Report

    Energy Technology Data Exchange (ETDEWEB)

    James E. Francfort

    2003-12-01

    Hydrogen has promise to be the fuel of the future. Its use as a chemical reagent and as a rocket propellant has grown to over eight million metric tons per year in the United States. Although use of hydrogen is abundant, it has not been used extensively as a transportation fuel. To assess the viability of hydrogen as a transportation fuel and the viability of producing hydrogen using off-peak electric energy, Pinnacle West Capital Corporation (PNW) and its electric utility subsidiary, Arizona Public Service (APS) designed, constructed, and operates a hydrogen and compressed natural gas fueling station—the APS Alternative Fuel Pilot Plant. This report summarizes the design of the APS Alternative Fuel Pilot Plant and presents lessons learned from its design and construction. Electric Transportation Applications prepared this report under contract to the U.S. Department of Energy’s Advanced Vehicle Testing Activity. The Idaho National Engineering and Environmental Laboratory manages these activities for the Advanced Vehicle Testing Activity.

  19. Designing Collaborative Manufacturing Solutions for SMEs

    DEFF Research Database (Denmark)

    Radziwon, Agnieszka; Bogers, Marcel; Bilberg, Arne

    2014-01-01

    In this paper, we investigate how small manufacturing companies can apply open innovation in the context of process innovation. We present a case study, with embedded action research elements, of a particular set of SMEs that implement a collaborative solution for manufacturing processes. We...

  20. Alternative Solution for Consumption Hot Water Recirculation for the Civil Buildings

    Directory of Open Access Journals (Sweden)

    Theodor Mateescu

    2007-01-01

    Full Text Available The sanitary comfort and the effective cost of maintenance in the civil buildings (block of flats are badly affected by the absence of the consumption hot water recirculation. From the technical point of view, the classical solution imposes the doubling of the transport and distribution pipes on the entire route, between the source and the consumption points. The materialization of the solution requires important financial investment, discouraging most of the time and the postponement of the problem solving with important consequences. This paper proposes an alternative technical solution which limits to a minimum the intervention, only in the interior hot water distribution system.

  1. Risk sensitivity, independence of irrelevant alternatives and continuity of bargaining solutions

    NARCIS (Netherlands)

    Wakker, P.P.; de Koster, R.; Peters, H.J.M.; Tijs, S.H.

    1983-01-01

    Bargaining solutions are considered which have the following four properties: individual rationality, Pareto optimality, independence of equivalent utility representations, and independence of irrelevant alternatives. A main result of this paper is a simple proof of the fact that all such bargaining

  2. An Evaluation of Alternative Designs for a Grid Information Service

    Science.gov (United States)

    Smith, Warren; Waheed, Abdul; Meyers, David; Yan, Jerry; Kwak, Dochan (Technical Monitor)

    2001-01-01

    The Globus information service wasn't working well. There were many updates of data from Globus daemons which saturated the single server and users couldn't retrieve information. We created a second server for NASA and Alliance. Things were great on that server, but a bit slow on the other server. We needed to know exactly how the information service was being used. What were the best servers and configurations? This viewgraph presentation gives an overview of the evaluation of alternative designs for a Grid Information Service. Details are given on the workload characterization, methodology used, and the performance evaluation.

  3. TA-designed vs. research-oriented problem solutions

    CERN Document Server

    Lin, Shih-Yin; Mamudi, William; Henderson, Charles R; Yerushalmi, Edit

    2016-01-01

    In order to study graduate teaching assistants (TAs) beliefs and values about the design of instructor problem solutions, twenty-four TAs were provided with different solutions and asked to discuss their preferences for prominent solution features. TAs preferences for solution features were examined in light of the modeling of expert-like problem solving process as recommended in the literature. Results suggest that while many of the features TAs valued align with expert-like problem solving approaches, they noticed primarily "surface features" of solutions. Moreover, self-reported preferences did not match well with the solutions TAs wrote on their own.

  4. Oxidative dissolution of spent nuclear fuel in aqueous alkaline solutions - An alternative to the Purex process?

    Energy Technology Data Exchange (ETDEWEB)

    Runde, Wolfgang; Peper, Shane; Brodnax, Lia; Crooks, William; Zehnder, Ralph; Jarvinen, Gordon

    2004-07-01

    As an alternative to acidic reprocessing of spent nuclear, oxidative dissolution of UO{sub 2} into aqueous alkaline solutions and subsequent separation of fission products is considered. The efficacy of such a method is limited by the kinetics of the UO{sub 2} dissolution and the capacity of alkaline solutions for dissolved U(VI) species. We performed a series of dissolution studies on UO{sub 2} and U{sub 3}O{sub 8} in aqueous alkaline solutions applying various oxidants. Among the oxidative agents commonly used to transform low-valence actinides into their higher oxidation states, H{sub 2}O{sub 2} has proven to be the most effective in basic media. Consequently, we investigated the dissolution of UO{sub 2} and U{sub 3}O{sub 8} in NaOH-H{sub 2}O{sub 2} and Na{sub 2}CO{sub 3}-H{sub 2}O{sub 2} solutions and determined the dissolution kinetics as a function of peroxide and hydroxide (carbonate) concentrations. Methods to remove fission products, e.g., Cs, Sr, Ba and Zr, from alkaline solutions will be evaluated based upon their decontamination factors. We will discuss the feasibility of using chemically oxidizing alkaline solutions as an alternative spent nuclear fuel reprocessing method based on results from experimental quantitative investigations. (authors)

  5. Designing Solutions using Response Surface Technique

    Directory of Open Access Journals (Sweden)

    COMAN Ovidiu

    2014-05-01

    Full Text Available In the present study a design of experiments method was used to obtain the most suitable responses. The variables that occur in the optimization are the movement of a dielectric material on Oy and Oz axis of a waveguide and the microwave power. The responses refer to the thermal field distribution, the reflected power, dielectric's temperature and the absorbed power.

  6. A note on “An alternative multiple attribute decision making methodology for solving optimal facility layout design selection problems”

    Directory of Open Access Journals (Sweden)

    R. Venkata Rao

    2012-04-01

    Full Text Available A paper published by Maniya and Bhatt (2011 (An alternative multiple attribute decision making methodology for solving optimal facility layout design selection problems, Computers & Industrial Engineering, 61, 542-549 proposed an alternative multiple attribute decision making method named as “Preference Selection Index (PSI method” for selection of an optimal facility layout design. The authors had claimed that the method was logical and more appropriate and the method gives directly the optimal solution without assigning the relative importance between the facility layout design selection attributes. This note discusses the mathematical validity and the shortcomings of the PSI method.

  7. Formal Validation of Fault Management Design Solutions

    Science.gov (United States)

    Gibson, Corrina; Karban, Robert; Andolfato, Luigi; Day, John

    2013-01-01

    The work presented in this paper describes an approach used to develop SysML modeling patterns to express the behavior of fault protection, test the model's logic by performing fault injection simulations, and verify the fault protection system's logical design via model checking. A representative example, using a subset of the fault protection design for the Soil Moisture Active-Passive (SMAP) system, was modeled with SysML State Machines and JavaScript as Action Language. The SysML model captures interactions between relevant system components and system behavior abstractions (mode managers, error monitors, fault protection engine, and devices/switches). Development of a method to implement verifiable and lightweight executable fault protection models enables future missions to have access to larger fault test domains and verifiable design patterns. A tool-chain to transform the SysML model to jpf-Statechart compliant Java code and then verify the generated code via model checking was established. Conclusions and lessons learned from this work are also described, as well as potential avenues for further research and development.

  8. Designing Integrated Product- Service System Solutions in Manufacturing Industries

    DEFF Research Database (Denmark)

    Costa, Nina; Patrício, Lia; Morelli, Nicola

    2015-01-01

    Manufacturing firms are increasingly evolving towards the design of integrated product-service solutions but servitization literature does not provide specific guidance on how to design these integrated solutions. Building upon ProductService System (PSS) and Service Design (SD) approaches......, this paper proposes an integrative method that joins PSS’s systems and network approach with the creative, human-centered, value cocreation approach of SD. The paper also describes the development and application of this method to the creation of integrated solutions for the laboratory industry, highlighting...

  9. Solution deposition of nanometer scale silver films as an alternative to vapor deposition for plasmonic excitation

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Derek S.; Sathish, R. Sai; Kostov, Yordan [Center for Advanced Sensor Technology and Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250 (United States); Rao, Govind, E-mail: grao@umbc.ed [Center for Advanced Sensor Technology and Department of Chemical and Biochemical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250 (United States)

    2010-05-03

    We report the attainment of surface plasmon-coupled emission (SPCE) from highly uniform thin silver films, solution-deposited on glass substrates by a wet chemistry approach. The surface morphology of these films was characterized by atomic force microscopy. The SPCE emission enhancements, polarization and angularity obtained from solution-deposited silver on BK7 glass were comparable to that achieved from conventional SPCE slides prepared via vapor deposition. This facile, wet chemistry procedure for the deposition of SPCE films provides an inexpensive, low maintenance alternative to vapor deposition for SPCE substrate preparation. This would allow the fluorescence observation technique to become more readily available for high sensitivity, low cost applications.

  10. Incorporating alternative design clinical trials in network meta-analyses

    Directory of Open Access Journals (Sweden)

    Thorlund K

    2014-12-01

    Full Text Available Kristian Thorlund,1–3 Eric Druyts,1,4 Kabirraaj Toor,1,5 Jeroen P Jansen,1,6 Edward J Mills1,3 1Redwood Outcomes, Vancouver, BC, 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; 3Stanford Prevention Research Center, Stanford University, Stanford, CA, USA; 4Department of Medicine, Faculty of Medicine, 5School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; 6Department of Public Health and Community Medicine, Tufts University, Boston, MA, USA Introduction: Network meta-analysis (NMA is an extension of conventional pairwise meta-analysis that allows for simultaneous comparison of multiple interventions. Well-established drug class efficacies have become commonplace in many disease areas. Thus, for reasons of ethics and equipoise, it is not practical to randomize patients to placebo or older drug classes. Unique randomized clinical trial designs are an attempt to navigate these obstacles. These alternative designs, however, pose challenges when attempting to incorporate data into NMAs. Using ulcerative colitis as an example, we illustrate an example of a method where data provided by these trials are used to populate treatment networks. Methods: We present the methods used to convert data from the PURSUIT trial into a typical parallel design for inclusion in our NMA. Data were required for three arms: golimumab 100 mg; golimumab 50 mg; and placebo. Golimumab 100 mg induction data were available; however, data regarding those individuals who were nonresponders at induction and those who were responders at maintenance were not reported, and as such, had to be imputed using data from the rerandomization phase. Golimumab 50 mg data regarding responses at week 6 were not available. Existing relationships between the available components were used to impute the expected proportions in this missing subpopulation. Data for placebo maintenance

  11. Solution of nonlinear Volterra-Hammerstein integral equations using alternative Legendre collocation method

    Directory of Open Access Journals (Sweden)

    Sohrab Bazm

    2016-11-01

    Full Text Available Alternative Legendre polynomials (ALPs are used to approximate the solution of a class of nonlinear Volterra-Hammerstein integral equations. For this purpose, the operational matrices of integration and the product for ALPs are derived. Then, using the collocation method, the considered problem is reduced into a set of nonlinear algebraic equations. The error analysis of the method is given and the efficiency and accuracy are illustrated by applying the method to some examples.

  12. Alternative Ultrasound Gel for a Sustainable Ultrasound Program: Application of Human Centered Design.

    Science.gov (United States)

    Salmon, Margaret; Salmon, Christian; Bissinger, Alexa; Muller, Mundenga Mutendi; Gebreyesus, Alegnta; Geremew, Haimanot; Wendel, Sarah K; Wendell, Sarah; Azaza, Aklilu; Salumu, Maurice; Benfield, Nerys

    2015-01-01

    This paper describes design of a low cost, ultrasound gel from local products applying aspects of Human Centered Design methodology. A multidisciplinary team worked with clinicians who use ultrasound where commercial gel is cost prohibitive and scarce. The team followed the format outlined in the Ideo Took Kit. Research began by defining the challenge "how to create locally available alternative ultrasound gel for a low-resourced environment? The "End-Users," were identified as clinicians who use ultrasound in Democratic Republic of the Congo and Ethiopia. An expert group was identified and queried for possible alternatives to commercial gel. Responses included shampoo, oils, water and cornstarch. Cornstarch, while a reasonable solution, was either not available or too expensive. We then sought deeper knowledge of locally sources materials from local experts, market vendors, to develop a similar product. Suggested solutions gleaned from these interviews were collected and used to create ultrasound gel accounting for cost, image quality, manufacturing capability. Initial prototypes used cassava root flour from Great Lakes Region (DRC, Rwanda, Uganda, Tanzania) and West Africa, and bula from Ethiopia. Prototypes were tested in the field and resulting images evaluated by our user group. A final prototype was then selected. Cassava and bula at a 32 part water, 8 part flour and 4 part salt, heated, mixed then cooled was the product design of choice.

  13. Alternative Ultrasound Gel for a Sustainable Ultrasound Program: Application of Human Centered Design.

    Directory of Open Access Journals (Sweden)

    Margaret Salmon

    Full Text Available This paper describes design of a low cost, ultrasound gel from local products applying aspects of Human Centered Design methodology. A multidisciplinary team worked with clinicians who use ultrasound where commercial gel is cost prohibitive and scarce. The team followed the format outlined in the Ideo Took Kit. Research began by defining the challenge "how to create locally available alternative ultrasound gel for a low-resourced environment? The "End-Users," were identified as clinicians who use ultrasound in Democratic Republic of the Congo and Ethiopia. An expert group was identified and queried for possible alternatives to commercial gel. Responses included shampoo, oils, water and cornstarch. Cornstarch, while a reasonable solution, was either not available or too expensive. We then sought deeper knowledge of locally sources materials from local experts, market vendors, to develop a similar product. Suggested solutions gleaned from these interviews were collected and used to create ultrasound gel accounting for cost, image quality, manufacturing capability. Initial prototypes used cassava root flour from Great Lakes Region (DRC, Rwanda, Uganda, Tanzania and West Africa, and bula from Ethiopia. Prototypes were tested in the field and resulting images evaluated by our user group. A final prototype was then selected. Cassava and bula at a 32 part water, 8 part flour and 4 part salt, heated, mixed then cooled was the product design of choice.

  14. LARM PKM solutions for torso design in humanoid robots

    Science.gov (United States)

    Ceccarelli, Marco

    2014-12-01

    Human-like torso features are essential in humanoid robots. In this paper problems for design and operation of solutions for a robotic torso are discussed by referring to experiences and designs that have been developed at Laboratory of Robotics and Mechatronics (LARM) in Cassino, Italy. A new solution is presented with conceptual views as waist-trunk structure that makes a proper partition of the performance for walking and arm operations as sustained by a torso.

  15. Titanium Implant Osseointegration Problems with Alternate Solutions Using Epoxy/Carbon-Fiber-Reinforced Composite.

    Science.gov (United States)

    Petersen, Richard C

    2014-12-01

    The aim of the article is to present recent developments in material research with bisphenyl-polymer/carbon-fiber-reinforced composite that have produced highly influential results toward improving upon current titanium bone implant clinical osseointegration success. Titanium is now the standard intra-oral tooth root/bone implant material with biocompatible interface relationships that confer potential osseointegration. Titanium produces a TiO2 oxide surface layer reactively that can provide chemical bonding through various electron interactions as a possible explanation for biocompatibility. Nevertheless, titanium alloy implants produce corrosion particles and fail by mechanisms generally related to surface interaction on bone to promote an inflammation with fibrous aseptic loosening or infection that can require implant removal. Further, lowered oxygen concentrations from poor vasculature at a foreign metal surface interface promote a build-up of host-cell-related electrons as free radicals and proton acid that can encourage infection and inflammation to greatly influence implant failure. To provide improved osseointegration many different coating processes and alternate polymer matrix composite (PMC) solutions have been considered that supply new designing potential to possibly overcome problems with titanium bone implants. Now for important consideration, PMCs have decisive biofunctional fabrication possibilities while maintaining mechanical properties from addition of high-strengthening varied fiber-reinforcement and complex fillers/additives to include hydroxyapatite or antimicrobial incorporation through thermoset polymers that cure at low temperatures. Topics/issues reviewed in this manuscript include titanium corrosion, implant infection, coatings and the new epoxy/carbon-fiber implant results discussing osseointegration with biocompatibility related to nonpolar molecular attractions with secondary bonding, carbon fiber in vivo properties, electrical

  16. Titanium Implant Osseointegration Problems with Alternate Solutions Using Epoxy/Carbon-Fiber-Reinforced Composite

    Directory of Open Access Journals (Sweden)

    Richard C. Petersen

    2014-12-01

    Full Text Available The aim of the article is to present recent developments in material research with bisphenyl-polymer/carbon-fiber-reinforced composite that have produced highly influential results toward improving upon current titanium bone implant clinical osseointegration success. Titanium is now the standard intra-oral tooth root/bone implant material with biocompatible interface relationships that confer potential osseointegration. Titanium produces a TiO2 oxide surface layer reactively that can provide chemical bonding through various electron interactions as a possible explanation for biocompatibility. Nevertheless, titanium alloy implants produce corrosion particles and fail by mechanisms generally related to surface interaction on bone to promote an inflammation with fibrous aseptic loosening or infection that can require implant removal. Further, lowered oxygen concentrations from poor vasculature at a foreign metal surface interface promote a build-up of host-cell-related electrons as free radicals and proton acid that can encourage infection and inflammation to greatly influence implant failure. To provide improved osseointegration many different coating processes and alternate polymer matrix composite (PMC solutions have been considered that supply new designing potential to possibly overcome problems with titanium bone implants. Now for important consideration, PMCs have decisive biofunctional fabrication possibilities while maintaining mechanical properties from addition of high-strengthening varied fiber-reinforcement and complex fillers/additives to include hydroxyapatite or antimicrobial incorporation through thermoset polymers that cure at low temperatures. Topics/issues reviewed in this manuscript include titanium corrosion, implant infection, coatings and the new epoxy/carbon-fiber implant results discussing osseointegration with biocompatibility related to nonpolar molecular attractions with secondary bonding, carbon fiber in vivo

  17. Parametric design of the Vela roof: A case study on performance oriented exploration of design alternatives

    NARCIS (Netherlands)

    Turrin, M.; Stouffs, R.M.F.; Sariyildiz, I.S.

    2010-01-01

    The paper presents a case study, in which parametric modeling has been used to explore the geometrical design alternatives of a large span roof. Explorative criteria are oriented to the use of on site energy resources, with specific focus on the mitigation of summer discomfort. After broadly

  18. FIXED FIELD ALTERNATING GRADIENT LATTICE DESIGN WITHOUT OPPOSITE BEND.

    Energy Technology Data Exchange (ETDEWEB)

    TRBOJEVIC,D.; BLASKIEWICZ,M.; COURANT,E.D.; GARREN,A.

    2002-06-02

    This report presents an attempt of the lattice design with a fixed field alternating gradient (FFAG) magnets without the usual opposite bends. It should allow particle acceleration through a small aperture. An example was made for the muon beam acceleration in an energy range 10-20 GeV with distributed RF cavities. The dispersion function for the central energy of 15 GeV has maximum value of the order of 7 cm. The lattice is composed of a combined function elements and sextupoles. We present the magnet configuration, orbit, chromaticities, tunes, and betatron function dependence on momentum (energies) during acceleration. For the lattice design we used SYNCH an MAD programs. For these large momentum offsets {delta}p/p = +-33% we found discrepancies between analytical and codes' results. This will be corrected in the new versions of codes (MAD-X). Because of uncertainties of the programs MAD and SYNCH some details of the presented results might not be correct.

  19. Improving conditions for reuse of design solutions - by means of a context based solution library

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Grothe-Møller, Thorkild; Andreasen, Mogens Myrup

    1997-01-01

    Among the most important reasoning mechanisms in design is reasoning by analogy. One precondition for being able to reason about the properties and functionalitues of a product or subsystem is that the context of the solution is known. This paper presents a computer based solution library where...

  20. NASA Alternative Orion Small Cell Battery Design Support

    Science.gov (United States)

    Haynes, Chuck

    2016-01-01

    and analysis were completed and reviewed for endorsement by NASA Engineering and Safety Center team members. All Key Test Objectives were met and the small cell design alternative was demonstrated and selected to be a feasible drop in replacement for the MPCV Orion CM Battery for EM2 mission.

  1. Design as co-evolution of problem, solution, and audience

    DEFF Research Database (Denmark)

    Halstrøm, Per Liljenberg; Galle, Per

    2014-01-01

    The meaning of ‘design’ can be captured in a general way by a good definition, but even the best definition cannot provide an understanding sufficiently deep to guide the professional designer or the student of design in the intricate deliberations of doing design in practice. Therefore we explore...... design beyond the level of definitions, reviewing canonical theories about design as a professional enterprise. We find that the well-established theoretical notion of ‘co-evolution’ of problem and solution in design has its merits in regard to understanding design deliberations; but also that existing...... conceptual resources for conceiving of design in terms of such triple co-evolution. For example, many design products may be thought of as offering an audience a ‘subject position’ that hint at whom they should become. In support of the case we make for thinking in terms of constitutive rhetoric in design...

  2. The study, design and simulation of a free piston Stirling engine linear alternatorThe study, design and simulation of a free piston Stirling engine linear alternator

    Directory of Open Access Journals (Sweden)

    Teodora Susana Oros

    2014-12-01

    Full Text Available This paper presents a study, design and simulation of a Free Piston Stirling Engine Linear Alternator. There are presented the main steps of the magnetic and electric calculations for a permanent magnet linear alternator of fixed coil and moving magnets type. Finally, a detailed thermal, mechanical and electrical model for a Stirling engine linear alternator have been made in SIMULINK simulation program. The linear alternator simulation model uses a controllable DC voltage which simulates the linear alternator combined with a rectifier, a variable load and a DC-DC converter, which compensates for the variable nature of Stirling engine operation, and ensures a constant voltage output regardless of the load.

  3. Lessons Learned During Solutions of Multidisciplinary Design Optimization Problems

    Science.gov (United States)

    Patnaik, Suna N.; Coroneos, Rula M.; Hopkins, Dale A.; Lavelle, Thomas M.

    2000-01-01

    Optimization research at NASA Glenn Research Center has addressed the design of structures, aircraft and airbreathing propulsion engines. During solution of the multidisciplinary problems several issues were encountered. This paper lists four issues and discusses the strategies adapted for their resolution: (1) The optimization process can lead to an inefficient local solution. This deficiency was encountered during design of an engine component. The limitation was overcome through an augmentation of animation into optimization. (2) Optimum solutions obtained were infeasible for aircraft and air-breathing propulsion engine problems. Alleviation of this deficiency required a cascading of multiple algorithms. (3) Profile optimization of a beam produced an irregular shape. Engineering intuition restored the regular shape for the beam. (4) The solution obtained for a cylindrical shell by a subproblem strategy converged to a design that can be difficult to manufacture. Resolution of this issue remains a challenge. The issues and resolutions are illustrated through six problems: (1) design of an engine component, (2) synthesis of a subsonic aircraft, (3) operation optimization of a supersonic engine, (4) design of a wave-rotor-topping device, (5) profile optimization of a cantilever beam, and (6) design of a cvlindrical shell. The combined effort of designers and researchers can bring the optimization method from academia to industry.

  4. An alternative to FASTSIM for tangential solution of the wheel-rail contact

    Science.gov (United States)

    Sichani, Matin Sh.; Enblom, Roger; Berg, Mats

    2016-06-01

    In most rail vehicle dynamics simulation packages, tangential solution of the wheel-rail contact is gained by means of Kalker's FASTSIM algorithm. While 5-25% error is expected for creep force estimation, the errors of shear stress distribution, needed for wheel-rail damage analysis, may rise above 30% due to the parabolic traction bound. Therefore, a novel algorithm named FaStrip is proposed as an alternative to FASTSIM. It is based on the strip theory which extends the two-dimensional rolling contact solution to three-dimensional contacts. To form FaStrip, the original strip theory is amended to obtain accurate estimations for any contact ellipse size and it is combined by a numerical algorithm to handle spin. The comparison between the two algorithms shows that using FaStrip improves the accuracy of the estimated shear stress distribution and the creep force estimation in all studied cases. In combined lateral creepage and spin cases, for instance, the error in force estimation reduces from 18% to less than 2%. The estimation of the slip velocities in the slip zone, needed for wear analysis, is also studied. Since FaStrip is as fast as FASTSIM, it can be an alternative for tangential solution of the wheel-rail contact in simulation packages.

  5. Design of future municipal wastewater treatment plants: A mathematical approach to manage complexity and identify optimal solutions

    DEFF Research Database (Denmark)

    Bozkurt, Hande; Quaglia, Alberto; Gernaey, Krist;

    technologies to build a superstructure, the design problem was formulated as a Mixed Integer Nonlinear Programming problem (MINLP). The tool generates many process alternatives and evaluates them with respect to their optimality. The objective function minimizes the operation cost. The design problem is thus...... with the help of the tool. The resulting solutions to the optimization problem are discussed in detail....

  6. Android design patterns interaction design solutions for developers

    CERN Document Server

    Nudelman, Greg

    2013-01-01

    Master the challenges of Android user interface development with these sample patterns With Android 4, Google brings the full power of its Android OS to both smartphone and tablet computing. Designing effective user interfaces that work on multiple Android devices is extremely challenging. This book provides more than 75 patterns that you can use to create versatile user interfaces for both smartphones and tablets, saving countless hours of development time. Patterns cover the most common and yet difficult types of user interactions, and each is supported with richly illustrate

  7. Designing and defining dynamic protein cage nanoassemblies in solution.

    Science.gov (United States)

    Lai, Yen-Ting; Hura, Greg L; Dyer, Kevin N; Tang, Henry Y H; Tainer, John A; Yeates, Todd O

    2016-12-01

    Central challenges in the design of large and dynamic macromolecular assemblies for synthetic biology lie in developing effective methods for testing design strategies and their outcomes, including comprehensive assessments of solution behavior. We created and validated an advanced design of a 600-kDa protein homododecamer that self-assembles into a symmetric tetrahedral cage. The monomeric unit is composed of a trimerizing apex-forming domain genetically linked to an edge-forming dimerizing domain. Enhancing the crystallographic results, high-throughput small-angle x-ray scattering (SAXS) comprehensively contrasted our modifications under diverse solution conditions. To generate a phase diagram associating structure and assembly, we developed force plots that measure dissimilarity among multiple SAXS data sets. These new tools, which provided effective feedback on experimental constructs relative to design, have general applicability in analyzing the solution behavior of heterogeneous nanosystems and have been made available as a web-based application. Specifically, our results probed the influence of solution conditions and symmetry on stability and structural adaptability, identifying the dimeric interface as the weak point in the assembly. Force plots comparing SAXS data sets further reveal more complex and controllable behavior in solution than captured by our crystal structures. These methods for objectively and comprehensively comparing SAXS profiles for systems critically affected by solvent conditions and structural heterogeneity provide an enabling technology for advancing the design and bioengineering of nanoscale biological materials.

  8. Updates since Brown v. Plata: alternative solutions for prison overcrowding in California.

    Science.gov (United States)

    Horne, Christopher; Newman, William J

    2015-03-01

    With the number of inmates under the care of the California Department of Corrections and Rehabilitation (CDCR) swelling over the past few decades, California faces a challenge. The U.S. Supreme Court ruled in their 2011 decision in Brown v. Plata that overcrowding violates inmates' Eighth Amendment rights, specifically that they are denied adequate medical and mental health care. Federally mandated release programs have historically raised some concerns regarding public safety and fiscal efficiency. Given the large number of mentally ill inmates in the United States, alternatives such as assisted outpatient treatment, mental health courts, and increased funding for substance use treatment can be used proactively to reduce the CDCR population and provide long-term solutions to the overcrowding problem. These alternatives have already shown long-term cost savings in addition to reducing the recidivism of individuals involved and would help provide appropriate diversion for mentally ill individuals.

  9. A Visual Analytics Based Decision Support Methodology For Evaluating Low Energy Building Design Alternatives

    Science.gov (United States)

    Dutta, Ranojoy

    The ability to design high performance buildings has acquired great importance in recent years due to numerous federal, societal and environmental initiatives. However, this endeavor is much more demanding in terms of designer expertise and time. It requires a whole new level of synergy between automated performance prediction with the human capabilities to perceive, evaluate and ultimately select a suitable solution. While performance prediction can be highly automated through the use of computers, performance evaluation cannot, unless it is with respect to a single criterion. The need to address multi-criteria requirements makes it more valuable for a designer to know the "latitude" or "degrees of freedom" he has in changing certain design variables while achieving preset criteria such as energy performance, life cycle cost, environmental impacts etc. This requirement can be met by a decision support framework based on near-optimal "satisficing" as opposed to purely optimal decision making techniques. Currently, such a comprehensive design framework is lacking, which is the basis for undertaking this research. The primary objective of this research is to facilitate a complementary relationship between designers and computers for Multi-Criterion Decision Making (MCDM) during high performance building design. It is based on the application of Monte Carlo approaches to create a database of solutions using deterministic whole building energy simulations, along with data mining methods to rank variable importance and reduce the multi-dimensionality of the problem. A novel interactive visualization approach is then proposed which uses regression based models to create dynamic interplays of how varying these important variables affect the multiple criteria, while providing a visual range or band of variation of the different design parameters. The MCDM process has been incorporated into an alternative methodology for high performance building design referred to as

  10. Variable speed drive as an alternative solution for a micro-hydro power plant

    OpenAIRE

    Akhtar, Malik Usman

    2012-01-01

    This diploma work is mainly focused on developing the control strategy for avariable speed drive as an alternative solution to a micro-hydro power plant. The detailed mathematical model for a micro-hydro system including a Kaplan turbine, mechanical shaft and electrical machines is presented and validated through simulations. A control strategy for an autonomous operation of a doubly-fed induction machine-based drive is developed for a wide range of speed. The drive can operate at a unity pow...

  11. Design Requirements, Epistemic Uncertainty and Solution Development Strategies in Software Design

    DEFF Research Database (Denmark)

    Ball, Linden J.; Onarheim, Balder; Christensen, Bo Thomas

    2010-01-01

    This paper investigates the potential involvement of “epistemic uncertainty” in mediating between complex design requirements and strategic switches in software design strategies. The analysis revealed that the designers produced an initial “first-pass” solution to the given design brief in a bre......This paper investigates the potential involvement of “epistemic uncertainty” in mediating between complex design requirements and strategic switches in software design strategies. The analysis revealed that the designers produced an initial “first-pass” solution to the given design brief...... a view of software design as involving a mixed breadth-first and depth-first solution development approach, with strategic switching to depth-first design being triggered by requirement complexity and being mediated by associated feelings of uncertainty....

  12. Values-led Participatory Design as a pursuit of meaningful alternatives

    DEFF Research Database (Denmark)

    Leong, Tuck Wah; Iversen, Ole Sejer

    2015-01-01

    Participatory Design (PD) is inherently concerned with inquiring into and supporting human values when designing IT. We argue that a PD approach that is led by a focus upon participants' values can allow participants to discover meaningful alternatives -- alternative uses and alternative conceptu......Participatory Design (PD) is inherently concerned with inquiring into and supporting human values when designing IT. We argue that a PD approach that is led by a focus upon participants' values can allow participants to discover meaningful alternatives -- alternative uses and alternative...... conceptualizations for IT that are particularly meaningful to them. However, how PD works with values in the design process has not been made explicit. In this paper, we aim to (i) explicate this values-led PD approach, (ii) illustrate how this approach can lead to outcomes that are meaningful alternatives, and (iii...

  13. Alternative design for extremely large telescopes and options to use the VATT for ELT design demonstration

    Science.gov (United States)

    Ackermann, Mark R.; McGraw, John T.; Zimmer, Peter C.

    2013-12-01

    A variety of optical designs for extremely large telescopes (ELTs) can be found throughout the technical literature. Most feature very fast primary mirrors of either conic or spherical figure. For those designs with conic primary mirrors, many of the optical approaches tend to be derivatives of either the aplanatic Cassegrain or Gregorian systems. The Cassegrain approach is more common as it results in a shorter optical system, but it requires a large convex aspheric secondary mirror, which is extremely difficult and expensive to test. The Gregorian approach is physically longer and suffers from greater field curvature. In some design variations, additional mirrors are added to reimage and possibly flatten a Cassegrain focus. An interesting alternative ELT design uses a small Cassegrain system to image the collimated output of a Gregorian-Mersenne concentrator. Another alternative approach, currently in favor for use on the European ELT, uses three powered mirrors and two flat mirrors to reimage a Cassegrain focus out the side similar to a Nasmyth system. A preliminary examination suggests that a small, fast primary mirror, such as that used on the VATT, might be used for a subscale prototype of current ELT optical design options.

  14. A MILP-based flux alternative generation and NMR experimental design strategy for metabolic engineering.

    Science.gov (United States)

    Phalakornkule, C; Lee, S; Zhu, T; Koepsel, R; Ataai, M M; Grossmann, I E; Domach, M M

    2001-04-01

    A mixed-integer linear program (MILP) is described that can enumerate all the ways fluxes can distribute in a metabolic network while still satisfying the same constraints and objective function. The multiple solutions can be used to (1) generate alternative flux scenarios that can account for limited experimental observations, (2) forecast the potential responses to mutation (e.g., new reaction pathways may be used), and (3) (as illustrated) design (13)C NMR experiments such that different potential flux patterns in a mutant can be distinguished. The experimental design is enabled by using the MILP results as an input to an isotopomer mapping matrices (IMM)-based program, which accounts for the network circulation of (13)C from a precursor such as glucose. The IMM-based program can interface to common plotting programs with the result that the user is provided with predicted NMR spectra that are complete with splittings and Lorentzian line-shape features. The example considered is the trafficking of carbon in an Escherichia coli mutant, which has pyruvate kinase activity deleted for the purpose of eliminating acetate production. Similar yields and extracellular measurements would be manifested by the flux alternatives. The MILP-IMM results suggest how NMR experiments can be designed such that the spectra of glutamate for two flux distribution scenarios differ significantly.

  15. The youth alternative solutions program: evaluating a hospital-based intervention for adolescent substance use.

    Science.gov (United States)

    Brown, Whitney N; D'Errico, Ellen; Morrell, Holly E R

    2015-01-01

    Issues of alcohol and drug use are more pronounced during adolescence than at any other period of the lifespan and represent a significant public health concern in the United States. As a result, there is currently a need for research on developmentally appropriate interventions for adolescent substance use (SU). Nurses and other mental health professionals working with adolescents need effective evidenced-based programs to refer clients having issues with SU. The current pilot study evaluated the effectiveness of the Youth Alternative Solutions Program, a hospital-based intervention program at a Level I trauma center in Southern California that partners with community stakeholders to accomplish its goals. A sample of 27 adolescents was recruited from August 2010 until October 2011. Twenty-seven total participants completed both pretest and posttest questionnaires; 14 of these participants also completed follow-up data collection. Results indicated a significant increase in negative alcohol outcome expectancies between the three study time points. More comprehensive studies of the Youth Alternative Solutions Program should be conducted in the future to determine the utility of hospital-based SU interventions and to provide evidence of the program's long-term effects.

  16. A Design and Implementation of Multicrypt Solution for DVB Receiver

    Institute of Scientific and Technical Information of China (English)

    Chen Jun(陈君); Sun Peng; Zeng Xuewen; Hou Ziqiang

    2004-01-01

    Conditional Access (CA) System is the essential basis of a Pay-TV System to charge the subscribers. This paper first introduces the standards and mechanisms for a Set-Top-Box(STB)to receive programs scrambled by different CA systems. Then, according to DVB multicrypt solution, a design in detail for such a DVB receiver, I.e. STB is presented. Decoder manufacturers provide STBs with the standard DVB common interface and CA system providers provide detachable CA modules to plug into the STBs through Common Interface. This solution allows broadcasters and customers to change CA system without replacing the STB. Such a design has been implemented in a decoder based on LSI SC2000, and is proved to be an open and secure solution for conditional access.

  17. Modular Design/Phased Construction Alternative Evaluation Report

    Energy Technology Data Exchange (ETDEWEB)

    Schwartztrauber, K.

    1999-05-28

    Modular design concepts are being considered for the license application during the surface facility design phase of the Monitored Geologic Repository (MGR). The Viability Assessment (VA) design is used as the reference design for the report. The primary objectives are to spread construction of the WHB and the subsurface repository over time to reduce annual project costs, and to provide a cost-effective design for the surface facilities that supports waste emplacement starting in the year 2010.

  18. An alternative solution for heavy liquid metal cooled reactors fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Vitale Di Maio, Damiano, E-mail: damiano.vitaledimaio@uniroma1.it [“SAPIENZA” University of Rome – DIAEE, Corso Vittorio Emanuele II, 244, 00186 Rome (Italy); Cretara, Luca; Giannetti, Fabio [“SAPIENZA” University of Rome – DIAEE, Corso Vittorio Emanuele II, 244, 00186 Rome (Italy); Peluso, Vincenzo [“ENEA”, Via Martiri di Monte Sole 4, 40129 Bologna (Italy); Gandini, Augusto [“SAPIENZA” University of Rome – DIAEE, Corso Vittorio Emanuele II, 244, 00186 Rome (Italy); Manni, Fabio [“SRS Engineering Design S.r.l.”, Vicolo delle Palle 25-25/b, 00186 Rome (Italy); Caruso, Gianfranco [“SAPIENZA” University of Rome – DIAEE, Corso Vittorio Emanuele II, 244, 00186 Rome (Italy)

    2014-10-15

    Highlights: • A new fuel assembly locking system for heavy metal cooled reactor is proposed. • Neutronic, mechanical and thermal-hydraulic evaluations of the system behavior have been performed. • A comparison with other solutions has been presented. - Abstract: In the coming future, the electric energy production from nuclear power plants will be provided by both thermal reactors and fast reactors. In order to have a sustainable energy production through fission reactors, fast reactors should provide an increasing contribution to the total electricity production from nuclear power plants. Fast reactors have to achieve economic and technical targets of Generation IV. Among these reactors, Sodium cooled Fast Reactors (SFRs) and Lead cooled Fast Reactors (LFRs) have the greatest possibility to be developed as industrial power plants within few decades. Both SFRs and LFRs require a great R and D effort to overcome some open issues which affect the present designs (e.g. sodium-water reaction for the SFRs, erosion/corrosion for LFRs, etc.). The present paper is mainly focused on LFR fuel assembly (FA) design: issues linked with the high coolant density of lead or lead–bismuth eutectic cooled reactors have been investigated and an innovative solution for the core mechanical design is here proposed and analyzed. The solution, which foresees cylindrical fuel assemblies and exploits the buoyancy force due to the lead high density, allows to simplify the FAs locking system, to reduce their length and could lead to a more uniform neutron flux distribution.

  19. Improving conditions for reuse of design solutions - by means of a context based solution library

    DEFF Research Database (Denmark)

    Mortensen, Niels Henrik; Grothe-Møller, Thorkild; Andreasen, Mogens Myrup

    1997-01-01

    Among the most important reasoning mechanisms in design is reasoning by analogy. One precondition for being able to reason about the properties and functionalitues of a product or subsystem is that the context of the solution is known. This paper presents a computer based solution library where...... solutions have context. The library has aluminium technology as application area and has been developed in co-operation between the Technical University of Denmark, SkanAluminium and leading aluminium companies within Scandinavia. The library has been tested in a number of companies and good results have...... been obtained. So fare more than 400 companies, universities and engineering academies have decided to utilise the solution library...

  20. Design Solutions for Reducing the Cogging Torque of PMSM

    Directory of Open Access Journals (Sweden)

    TUDORACHE, T.

    2013-08-01

    Full Text Available This paper analyzes design solutions able to reduce the Cogging Torque (CT amplitude of Permanent Magnet Synchronous Machines (PMSMs. The common point of these solutions is the particular constructions of the stator magnetic core from two concentric steel lamination stacks that leads to a closed stator slots structure in the air-gap region. The efficiency of the studied solutions is evaluated by Finite Element (FE analysis for two different types of PMSMs: the first one with Surface Permanent Magnets (SPMs and the second one with Interior Permanent Magnets (IPMs. The influence of the special stator constructions on the performances of the two types of machines is emphasized also in the paper, with positive and negative effects. This study proves that a PMSM whose stator magnetic core is designed as shown, leads to an important decrease of CT amplitude in comparison with a classical machine. Moreover, the studied design solutions may be mixed with other CT reduction methods so as to optimize the overall PMSM performance. A part of the numerical model results were experimentally validated.

  1. Alternative positron-target design for electron-positron colliders

    Energy Technology Data Exchange (ETDEWEB)

    Donahue, R.J. (Lawrence Berkeley Lab., CA (United States)); Nelson, W.R. (Stanford Linear Accelerator Center, Menlo Park, CA (United States))

    1991-04-01

    Current electron-positron linear colliders are limited in luminosity by the number of positrons which can be generated from targets presently used. This paper examines the possibility of using an alternate wire-target geometry for the production of positrons via an electron-induced electromagnetic cascade shower. 39 refs., 38 figs., 5 tabs.

  2. Solution-Processed Rare-Earth Oxide Thin Films for Alternative Gate Dielectric Application.

    Science.gov (United States)

    Zhuang, Jiaqing; Sun, Qi-Jun; Zhou, Ye; Han, Su-Ting; Zhou, Li; Yan, Yan; Peng, Haiyan; Venkatesh, Shishir; Wu, Wei; Li, Robert K Y; Roy, V A L

    2016-11-16

    Previous investigations on rare-earth oxides (REOs) reveal their high possibility as dielectric films in electronic devices, while complicated physical methods impede their developments and applications. Herein, we report a facile route to fabricate 16 REOs thin insulating films through a general solution process and their applications in low-voltage thin-film transistors as dielectrics. The formation and properties of REOs thin films are analyzed by atomic force microscopy (AFM), X-ray diffraction (XRD), spectroscopic ellipsometry, water contact angle measurement, X-ray photoemission spectroscopy (XPS), and electrical characterizations, respectively. Ultrasmooth, amorphous, and hydrophilic REO films with thickness around 10 nm have been obtained through a combined spin-coating and postannealing method. The compositional analysis results reveal the formation of RE hydrocarbonates on the surface and silicates at the interface of REOs films annealed on Si substrate. The dielectric properties of REO films are investigated by characterizing capacitors with a Si/Ln2O3/Au (Ln = La, Gd, and Er) structure. The observed low leakage current densities and large areal capacitances indicate these REO films can be employed as alternative gate dielectrics in transistors. Thus, we have successfully fabricated a series of low-voltage organic thin-film transistors based on such sol-gel derived REO films to demonstrate their application in electronics. The optimization of REOs dielectrics in transistors through further surface modification has also been studied. The current study provides a simple solution process approach to fabricate varieties of REOs insulating films, and the results reveal their promising applications as alternative gate dielectrics in thin-film transistors.

  3. Application of the Fuzzy Comprehensive Assessment Technique to Optimal Selection of Pipeline Design Alternative

    Institute of Scientific and Technical Information of China (English)

    ChuFeixue; ChuYanfan; LiuXiumin

    2005-01-01

    Regarding the influencing factors in an optimal selection of pipeline design alternative as fuzzy variables with different weights, a fuzzy comprehensive assessment was applied to an optimal selection of the design alternative. Giving the Lanzhou-Chengdu pipeline as an example to explain the process, the result shows that this method is acceptable.

  4. Alternate space shuttle concepts study: Design requirements and phased programs evaluation

    Science.gov (United States)

    1971-01-01

    A study to determine program and technical alternatives to the design of the space shuttle orbiter is described. The alternatives include a phased approach, involving orbiter development and operation with an expendable booster for an interim period, as well as design variations to the basic vehicle. The space shuttle orbiter configurations and predicted performance parameters are presented.

  5. Optimal Design Solutions for Permanent Magnet Synchronous Machines

    Directory of Open Access Journals (Sweden)

    POPESCU, M.

    2011-11-01

    Full Text Available This paper presents optimal design solutions for reducing the cogging torque of permanent magnets synchronous machines. A first solution proposed in the paper consists in using closed stator slots that determines a nearly isotropic magnetic structure of the stator core, reducing the mutual attraction between permanent magnets and the slotted armature. To avoid complications in the windings manufacture technology the stator slots are closed using wedges made of soft magnetic composite materials. The second solution consists in properly choosing the combination of pole number and stator slots number that typically leads to a winding with fractional number of slots/pole/phase. The proposed measures for cogging torque reduction are analyzed by means of 2D/3D finite element models developed using the professional Flux software package. Numerical results are discussed and compared with experimental ones obtained by testing a PMSM prototype.

  6. Alternate solutions for mine ventilation network to keep a pre-assigned fixed quantity in a working place

    Institute of Scientific and Technical Information of China (English)

    K A El-Nagdy; A M Shoaib

    2015-01-01

    In underground constructions, a good ventilation design not only delivers fresh air to establish good working environment, but also provides a scientific and reliable basis to prevent disasters. In emergency cases, unexpected closure of the main airways may occur, providing the workers with alternative airways is substantial. This is important not only to sustain personnel lives, but also to prevent the mine ventilation system from damage. In this research, alternate solutions were introduced in case of failure in the underground construction to keep a pre-assigned fixed quantity in a working place for mine ventilation network. Eight different collapse scenarios were proposed to study their effect on the air quantity distribution among the branches in the ventilation circuit. From these scenarios, it is found that providing a sufficient air quantity in the working places could be achieved through modification of the network topology and adjusting the values of the regulators pressure. It is also indicated that the distance between the collapse and working places has a great effect on the amount of air delivered to it. A reduction in the power consumption could be done by re-arrange the installed regulators and decreasing the number of nodes and branches inside the network. A relationship representing the effect of changing the network topology on the total network power consumption was deduced through regression analysis. It is found that the total network power is quadratic dependent on the number of regulators and number of branches while it is directly dependent on the regulator power.

  7. Solute segregation in directional solidification of GaInSb concentrated alloys under alternating magnetic fields

    Science.gov (United States)

    Stelian, Carmen; Delannoy, Yves; Fautrelle, Yves; Duffar, Thierry

    2004-05-01

    Numerical simulations of the vertical Bridgman solidification of Ga 1- xIn xSb concentrated alloys are performed by using the commercial codes FIDAP ® and FLUENT ®. The transient axi-symmetric simulation of heat, mass and species transport during highly doped ( x=0.2) crystal growth, shows a strong solute effect on the melt convection. The thermally driven flow is damped by the heavier solute (InSb) rejected at the solid-liquid interface. A diffusive transport regime is established in the melt a short time after the beginning of solidification and as a consequence, the radial segregation increases. This leads to a significant increase of the interface curvature because of the melting point dependency on the interface composition. Finally, the crystals are not chemically homogeneous with large variations of InSb concentration on the axial and radial directions. In order to improve the chemical homogeneity of highly doped Ga 1- xIn xSb crystals, it is proposed to apply an alternating magnetic field in the vicinity of the solid-liquid interface. The magnetic parameters for which an optimal level of convection arises in the melt are derived from the numerical simulation. It is shown that during solidification under optimized electromagnetic stirring, the radial segregation and interface deflection can be maintained at low values.

  8. DESIGN SOLUTIONS FOR NOISE PROTECTION OF THE POPULATION

    Directory of Open Access Journals (Sweden)

    Vasineva M. V.

    2015-05-01

    Full Text Available The article is devoted to the solution of actual problems of protection of the population from noise production facilities. It shows the various fundamental technological approaches to the implementation of noise protection measures. This work conducts a comparative assessment of technical solutions aimed at reducing the levels of radiated noise, providing increased noise impact on the territory, from the gas distribution station (GDS. Production facilities everywhere are equipped with noisy equipment. If the noise level from the object in a residential area exceeds the permissible levels (RC, they sound events. The most common design decisions noise protection for today are: sound design; noise screens and barriers; insulating housings; sound cab. The article discusses the insulating properties of different coatings, composition and device of acoustic screens. It describes the course of the design work noise-reducing measures aimed at reducing noise levels in a residential area adjacent to the territory of one of the gas distribution stations (GDS. The description of the algorithm calculations, selection of materials for the implementation of activities, the combination of technical solutions that have practical novelty. The article is an exploratory in nature. At each stage of the embodiment of the design decisions were changes in the level of noise and the sound spectrum in the frequency range of 31.5 to 8000 Hz, evaluation of the effectiveness of the protective measures and the analysis of the influence of acoustic impact on the population. The results were presented for the year of research. The results of the research indicated graphically demonstrate the advantages of the proposed solutions for reducing noise levels in a residential area

  9. Alternative sampling designs and estimators for annual surveys

    Science.gov (United States)

    Paul C. Van Deusen

    2000-01-01

    Annual forest inventory systems in the United States have generally converged on sampling designs that: (1) measure equal proportions of the total number of plots each year; and (2) call for the plots to be systematically dispersed. However, there will inevitably be a need to deviate from the basic design to respond to special requests, natural disasters, and budgetary...

  10. Environmental comparison of a railway bridge with alternative designs

    DEFF Research Database (Denmark)

    Du, Guangli; Karoumi, Raid

    2012-01-01

    . The assessment considers the key environmental category of global warming potential from 'cradle to gate', which covers the material production and distribution process. The result shows that the fixed-slab design indicates a better environmental performance than the ballast track design....

  11. NPS alternate techsat satellite, design project for AE-4871

    Science.gov (United States)

    1993-01-01

    This project was completed as part of AE-4871, Advanced Spacecraft Design. The intent of the course is to provide experience in the design of all the major components in a spacecraft system. Team members were given responsibility for the design of one of the six primary subsystems: power, structures, propulsion, attitude control, telemetry, tracking and control (TT&C), and thermal control. In addition, a single member worked on configuration control, launch vehicle integration, and a spacecraft test plan. Given an eleven week time constraint, a preliminary design of each subsystem was completed. Where possible, possible component selections were also made. Assistance for this project came principally from the Naval Research Laboratory's Spacecraft Technology Branch. Specific information on components was solicited from representatives in industry. The design project centers on a general purpose satellite bus that is currently being sought by the Strategic Defense Initiative.

  12. Implications of solar energy alternatives for community design

    Energy Technology Data Exchange (ETDEWEB)

    Santos, A.; Steinitz, C.

    1980-06-01

    A graduate-level studio at the Harvard School of Design explored how a policy of solar-based energy independence will influence the design of a new community of approximately 4500 housing units and other uses. Three large sites outside Tucson (a cooling problem), Atlanta (a humidity problem), and Boston (a heating problem) were selected. Each is typical of its region. A single program was assumed and designed for. Each site had two teams, one following a compact approach and one following a more dispersed approach. Each was free to choose the most appropriate mix of (solar) technology and scale, and was free to integrate energy and community in the design as it saw fit. These choice and integration issues are key areas where our experience may be of interest to those involved in community design and solar energy.

  13. Alternative solution for ex vivo lung perfusion, experimental study on donated human lungs non-accepted for transplantation.

    Science.gov (United States)

    Fernandes, Lucas Matos; Mariani, Alessandro Wasum; Medeiros, Israel Lopes de; Samano, Marcos Naoyuki; Abdalla, Luís Gustavo; Correia, Aristides Tadeu; Nepomuceno, Natália Aparecida; Canzian, Mauro; Pêgo-Fernandes, Paulo Manuel

    2015-05-01

    To evaluate a new perfusate solution to be used for ex vivo lung perfusion. Randomized experimental study using lungs from rejected brain-dead donors harvested and submitted to 1 hour of ex vivo lung perfusion (EVLP) using mainstream solution or the alternative. From 16 lungs blocs tested, we found no difference on weight after EVLP: Steen group (SG) = 1,097±526g; Alternative Perfusion Solution (APS) = 743±248g, p=0.163. Edema formation, assessed by Wet/dry weigh ratio, was statistically higher on the Alternative Perfusion Solution group (APS = 3.63 ± 1.26; SG = 2.06 ± 0.28; p = 0.009). No difference on PaO2 after EVLP (SG = 498±37.53mmHg; APS = 521±55.43mmHg, p=0.348, nor on histological analyses: pulmonary injury score: SG = 4.38±1.51; APS = 4.50±1.77, p=0.881; apoptotic cells count after perfusion: SG = 2.4 ± 2.0 cells/mm2; APS = 4.8 ± 6.9 cells/mm2; p = 0.361). The ex vivo lung perfusion using the alternative perfusion solution showed no functional or histological differences, except for a higher edema formation, from the EVLP using Steen Solution(r) on lungs from rejected brain-dead donors.

  14. Designing medical and educational intervention studies. A review of some alternatives to conventional randomized controlled trials

    OpenAIRE

    Bradley, Clare

    1993-01-01

    The advantages and limitations of RCT designs are discussed, and a range of alternative designs for medical and educational intervention studies considered. Designs selected are those that address the much neglected psychological issues involved in the recruitment of patients and allocation of patients to treatments within trials. Designs include Zelen's (18) randomized consent design, Brewin and Bradley's (20) partially randomized patient-centered design, and Korn and Baumrind's (21) partial...

  15. Engineering Value-Effective Healthcare Solutions: A Systems Design Perspective

    DEFF Research Database (Denmark)

    Patou, François; Maier, Anja

    2017-01-01

    Our modern healthcare systems commonly face an important dilemma. While they depend on innovation to provide continuously greater healthcare value, they also struggle financially with the burden of adopting a continuous flow of new products and services. Although several disruptive healthcare...... models, i.e. decentralised, personalised, pervasive, connected, and stratified, promise to relieve some of this tension, they do not per se guarantee optimal value generation. We argue that systems thinking and engineering design can remedy this limitation. We support this claim by making the case...... of Design for Evolvability and by elaborating on two examples: MRI systems and Point-of-Care in-vitro diagnostics solutions. We specifically argue that Design for Evolvability can realign the agendas of various healthcare stakeholders, serving both individual and national interests. We finally acknowledge...

  16. Oxidative degradation of alternative gasoline oxygenates in aqueous solution by ultrasonic irradiation: Mechanistic study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Duk Kyung, E-mail: dkim@aum.edu [Department of Physical Science, Auburn University Montgomery, Montgomery, AL 36117 (United States); O' Shea, Kevin E., E-mail: osheak@fiu.edu [Department of Chemistry and Biochemistry, Florida International University, University Park, Miami, FL 33199 (United States); Cooper, William J. [Department of Civil and Environmental Engineering, Urban Water Research Center, University of California Irvine, Irvine, CA 92697-2175 (United States)

    2012-07-15

    Widespread pollution has been associated with gasoline oxygenates of branched ethers methyl tert-butyl ether (MTBE), di-isopropyl ether (DIPE), ethyl tert-butyl ether (ETBE), and tert-amyl ether (TAME) which enter groundwater. The contaminated plume develops rapidly and treatment for the removal/destruction of these ethers is difficult when using conventional methods. Degradation of MTBE, with biological methods and advanced oxidation processes, are rather well known; however, fewer studies have been reported for degradation of alternative oxygenates. Degradation of alternative gasoline oxygenates (DIPE, ETBE, and TAME) by ultrasonic irradiation in aqueous oxygen saturation was investigated to elucidate degradation pathways. Detailed degradation mechanisms are proposed for each gasoline oxygenate. The common major degradation pathways are proposed to involve abstraction of {alpha}-hydrogen atoms by hydroxyl radicals generated during ultrasound cavitation and low temperature pyrolytic degradation of ETBE and TAME. Even some of the products from {beta}-H abstraction overlap with those from high temperature pyrolysis, the effect of {beta}-H abstraction was not shown clearly from product study because of possible 1,5 H-transfer inside cavitating bubbles. Formation of hydrogen peroxide and organic peroxides was also determined during sonolysis. These data provide a better understanding of the degradation pathways of gasoline oxygenates by sonolysis in aqueous solutions. The approach may also serve as a model for others interested in the details of sonolysis. - Highlights: Black-Right-Pointing-Pointer Gasoline oxygenates (ETBE, TAME, DIPE) were completely degraded after 6 hours under ultrasonic irradiation in O{sub 2} saturation. Black-Right-Pointing-Pointer The major degradation pathways were proposed to involve abstraction of {alpha}-hydrogen atoms by hydroxyl radicals and low temperature pyrolytic degradation. Black-Right-Pointing-Pointer The effect of {beta

  17. Design element alternatives for stress-management intervention websites.

    Science.gov (United States)

    Williams, Reg A; Gatien, Gary; Hagerty, Bonnie

    2011-01-01

    Typical public and military-sponsored websites on stress and depression tend to be prescriptive. Some require users to complete lengthy questionnaires. Others reproduce printed flyers, papers, or educational materials not adapted for online use. Some websites require users to follow a prescribed path through the material. Stress Gym was developed as a first-level, evidence-based, website intervention to help U.S. military members learn how to manage mild to moderate stress and depressive symptoms using a self-help intervention with progress tracking and 24/7 availablility. It was designed using web-based, health-management intervention design elements that have been proven effective and users reported they prefer. These included interactivity, self-pacing, and pleasing aesthetics. Users learned how to manage stress by accessing modules they choose, and by practicing proven stress management strategies interactively immediately after login. Test results of Stress Gym with Navy members demonstrated that it was effective, with significant decreases in reported perceived stress levels from baseline to follow-up assessment. Stress Gym used design elements that may serve as a model for future websites to emulate and improve upon, and as a template against which to compare and contrast the design and functionality of future online, health-intervention websites.

  18. ALTERNATE MATERIALS IN DESIGN OF RADIOACTIVE MATERIAL PACKAGES

    Energy Technology Data Exchange (ETDEWEB)

    Blanton, P.; Eberl, K.

    2010-07-09

    This paper presents a summary of design and testing of material and composites for use in radioactive material packages. These materials provide thermal protection and provide structural integrity and energy absorption to the package during normal and hypothetical accident condition events as required by Title 10 Part 71 of the Code of Federal Regulations. Testing of packages comprising these materials is summarized.

  19. Zwitterions as alternative draw solutions in forward osmosis for application in wastewater reclamation

    NARCIS (Netherlands)

    Lutchmiah, K.; Lauber, L.; Roest, de K.; Harmsen, D.J.H.; Post, J.W.; Rietveld, L.C.; Lier, van J.B.; Cornelissen, E.R.

    2014-01-01

    The draw solution is the driving force in forward osmosis (FO) processes. The reverse solute leakage of the draw solution is however a major constraint due to cost and energy requirements when reconcentrating the solutes subsequent to the FO process. Several zwitterions as draw solutions (pi approxi

  20. The Problem of Olive Mill Wastewater in Turkey and some Solution Alternatives

    Directory of Open Access Journals (Sweden)

    Renan Tunalioğlu

    2012-03-01

    Full Text Available Olive, as a fruit, cannot be consumed directly due to the oleuropein substance it contains and needs to be processed into either table olives or olive oil through various production systems. The process of olive oil extraction results in olive oil as the main product, and two by-products, with olive pomace being one and brown-coloured Olive Mill Wastewater (OMWW as the other. OMWW has no direct use and it is usually discharged directly to soil, small rivers, lakes or sea, resulting in potential contamination of the environment. Turkey is the fourth largest olive producing country in the world and fifth in olive oil production. Turkey produces approximately 891 393 tonnes of OMWW on average per two years using the current mill production technologies, and hence faces the problem of OMWW. This study proposes and discusses various solution alternatives to overcome the problem of OMWW in Turkey. The results of this study aim to contribute to the ongoing efforts in resolving this problem by the olive industry and to aid policy making to tackle this important issue.

  1. The Problem of Olive Mill Wastewater in Turkey and some Solution Alternatives

    Directory of Open Access Journals (Sweden)

    Renan Tunalioglu

    2014-02-01

    Full Text Available Olive, as a fruit, cannot be consumed directly due to the oleuropein substance it contains and needs to be processed into either table olives or olive oil through various production systems. The process of olive oil extraction results in olive oil as the main product, and two by-products, with olive pomace being one and brown-coloured Olive Mill Wastewater (OMWW as the other. OMWW has no direct use and it is usually discharged directly to soil, small rivers, lakes or sea, resulting in potential contamination of the environment. Turkey is the fourth largest olive producing country in the world and fifth in olive oil production. Turkey produces approximately 891 393 tonnes of OMWW on average per two years using the current mill production technologies, and hence faces the problem of OMWW. This study proposes and discusses various solution alternatives to overcome the problem of OMWW in Turkey. The results of this study aim to contribute to the ongoing efforts in resolving this problem by the olive industry and to aid policy making to tackle this important issue.

  2. Designing a total data solution technology, implementation, and deployment

    CERN Document Server

    Burkey, Roxanne

    2000-01-01

    Your company's global competitiveness depends on the utilization and maintenance of information. Current data handling practices-storing, updating, and accessing data-can be either a problem or a significant strategic advantage for your company. Designing a Total Data Storage Solution: Technology, Implementation, and Deployment gives you the information you need to compare current technologies and determine which is best suited to your enterprise.This book defines and explains the components that make up total cost of ownership along with the impact of integrating current changes in technology

  3. Energy savings solutions: passive solar design in Iranian cold climate

    Energy Technology Data Exchange (ETDEWEB)

    Nassehzadeh Tabriz, Shahram [Department of Architecture, Miyaneh Branch, Islamic Azad University (Iran, Islamic Republic of)], email: sh_nassehzadeh@m-iau.ac.ir; Mahdavi Tabatabaei Fard, Fariborz [SABAT TARH CO. (Iran, Islamic Republic of)], email: sabat_arc@yahoo.com; Aliyev, Fagan [International Eco-energy Academy (Azerbaijan)], email: ie_academy@yahoo.com

    2011-07-01

    In recent years, there has been a significant increase in the cost of fuel gas, fuel oil and electricity and much thought has been given to the use of solar energy. Living in a solar heated house gives peace of mind and body and it makes good sense in mountainous regions. Severe winters in such regions make more energy for standard living activities in buildings necessary. This paper discusses passive solar building design as an energy saving solution. In this type of design, windows, walls and floors act as storage and distribution devices for solar energy in winter and deflect solar heat in summer. Passive solar design techniques influence the choice of building site, design and materials within the general framework of enriching the quality of life of the inhabitants. As a result, natural resources are saved and the environment is conserved for future generations. In conclusion, it is seen that passive design keeps a home cool and comfortable in summer and warm and cozy in winter with minimal heating and cooling requirements.

  4. Alternatives generation and analysis for phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Britton, M.D.

    1996-10-02

    This document provides; a decision analysis summary; problem statement; constraints, requirements, and assumptions; decision criteria; intermediate waste feed staging system options and alternatives generation and screening; intermediate waste feed staging system design concepts; intermediate waste feed staging system alternative evaluation and analysis; and open issues and actions.

  5. An Alternative View of Some FIA Sample Design and Analysis Issues

    Science.gov (United States)

    Paul C. Van Deusen

    2005-01-01

    Sample design and analysis decisions are the result of compromises and inputs from many sources. The end result would likely change if different individuals or groups were involved in the planning process. Discussed here are some alternatives to the procedures that are currently being used for the annual inventory. The purpose is to indicate that alternatives exist and...

  6. Evaluation of Alternate Ion Exchange Designs for CST Non-Elutable Ion Exchange Process

    Energy Technology Data Exchange (ETDEWEB)

    Yen, S.N.; Pike, J.A.; Jacobs, R.A.; Poirier, M.R.; Sahawneh, B.M.; Leugemors, R.K.

    2001-06-27

    A study of alternative column designs was initiated in late 2000 to explore ion exchange column design concepts outside of the baseline case. The study, which is discussed in detail in the report, has identified two promising commercially proven ion-exchange column designs as candidates to be developed further for application to CST ion-exchange technology.

  7. Designing e-learning solutions with a client centred approach

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Nielsen, Janni; Levinsen, Karin

    2008-01-01

    as the organisation that has initiated the e-learning project and needs to manage the e-learning system after its development. Through the Client Centred Design and in close collaboration with the client, three strategic issues are uncovered and strategic models are presented for each. These models are complementary......  This paper claims that the strategies applied in designing e-learning solutions tend to focus on how to proceed after the precondition, e.g., learners requirements, pedagogical choice, etc., have been decided upon. Investigating the HCI research field, we find that the methodological approaches...... perspectives in a Client Centred framework that is useable as the starting point for others in developing large scale e-learning projects....

  8. Alternative Design for Visual Identity of Yayasan Batik Indonesia

    Directory of Open Access Journals (Sweden)

    Puspita Putri Nugroho

    2015-06-01

    Full Text Available The research objective is to create a logo as the main visual identity. It is together with the graphic elements to support the overall visual identity of the organization and also apply the corporate identity to various applications to effectively foster the professional and trustworthy image of the organization as the foundation in Indonesia aiming for preserving and advancing Batik as the national asset. The writer used qualitative and quantitative method. Qualitative method included Face-to-face interview with the vice secretary of YBI, e-mail interview with the previous logo designer and direct survey to Textile Museum Jakarta and Batik Gallery; and Quantitative method through online survey. The result of the project is a new visual identity for Yayasan Batik Indonesia, which portrays its vision and mission. Design is the core in attaining an advantageous visual identity that could portray the image of the respected organization. When a consistency is applied through the whole visual identity, professional character of the organization is achieved.

  9. Computational issues in alternating projection algorithms for fixed-order control design

    DEFF Research Database (Denmark)

    Beran, Eric Bengt; Grigoriadis, K.

    1997-01-01

    Alternating projection algorithms have been introduced recently to solve fixed-order controller design problems described by linear matrix inequalities and non-convex coupling rank constraints. In this work, an extensive numerical experimentation using proposed benchmark fixed-order control design...... examples is used to indicate the computational efficiency of the method. These results indicate that the proposed alternating projections are effective in obtaining low-order controllers for small and medium order problems...

  10. Design solutions for dome and main structure (mount) of giant telescopes

    Science.gov (United States)

    Murga, Gaizka; Bilbao, Armando; de Bilbao, Lander; Lorentz, Thomas E.

    2016-07-01

    During the last recent years, designs for several giant telescopes ranging from 20 to 40m in diameter are being developed: European Extremely Large Telescope Telescope (TMT). (E-ELT), Giant Magellan Telescope (GMT) and Thirty Meter It is evident that simple direct up-scaling of solutions that were more or less successful in the 8 to 10m class telescopes can not lead to viable designs for the future giant telescopes. New solutions are required to provide adequate load sharing, to cope with the large-scale derived deflections and to provide the required compliance, or to respond to structure-mechanism control interaction issues, among others. From IDOM experience in the development of the Dome and Main Structure of the European Extremely Large Telescope and our participation in some other giant telescopes, this paper reviews several design approaches for the main mechanisms and key structural parts of enclosures and mounts/main structures for giant telescopes, analyzing pros and cons of the different alternatives and outlining the preferred design schemes. The assessment is carried out mainly from a technical and performance-based angle but it also considers specific logistical issues for the assembly of these large telescopes in remote and space-limited areas, together with cost and schedule related issues.

  11. Generating Alternative Engineering Designs by Integrating Desktop VR with Genetic Algorithms

    Science.gov (United States)

    Chandramouli, Magesh; Bertoline, Gary; Connolly, Patrick

    2009-01-01

    This study proposes an innovative solution to the problem of multiobjective engineering design optimization by integrating desktop VR with genetic computing. Although, this study considers the case of construction design as an example to illustrate the framework, this method can very much be extended to other engineering design problems as well.…

  12. Generating Alternative Engineering Designs by Integrating Desktop VR with Genetic Algorithms

    Science.gov (United States)

    Chandramouli, Magesh; Bertoline, Gary; Connolly, Patrick

    2009-01-01

    This study proposes an innovative solution to the problem of multiobjective engineering design optimization by integrating desktop VR with genetic computing. Although, this study considers the case of construction design as an example to illustrate the framework, this method can very much be extended to other engineering design problems as well.…

  13. DESIGNING DEPENDABLE AGILE LAYERED WEB SERVICES SECURITY ARCHITECTURE SOLUTIONS

    Directory of Open Access Journals (Sweden)

    M.UPENDRA KUMAR

    2011-06-01

    Full Text Available Service Orientation Engineering (SOE (using Web Services and Agile modeling software development presents promising solutions for contemporary software development projects to deal effectively withchallenges in increasingly turbulent business environments typified by unpredictable markets, changing customer requirements, pressures of even shorter time to deliver, and rapidly advancing informationtechnologies. Web Services Security Architectures have three layers, as provided by NIST standard: Web Service Layer, Web Services Framework Layer (.NET or J2EE, and Web Server Layer. In services oriented web services architecture, business processes are executed as a composition of services, which can suffer from vulnerabilities pertaining to secure data access and protecting code of Web Services. The goal of the Web services security architecture is to summary out the details of message-level security from the mainstream business logic, with a focus on Web Service contract design and versioning for SOA. Service oriented web services architectures impose additional analysis complexity as they provide much flexibility and frequentchanges with in orchestrated processes and services. In this paper, we discuss about developing dependable solutions for Web Services Security Architectures using Agile Layered security architectures in terms of Privacy requirements. All this research is motivated by Secure Service Oriented Analysis and Design research domain. We initially validate this by a BPEL Editor using GWT for RBAC and Privacy. Finally a real world case study is implemented using J2EE, for validating our approach. Secure Stock Exchange System using Web Services is to automate the stock exchange works, and can help user make the decisions when it comes to investment.

  14. Privacy by Design: An alternative to existing practice in safeguarding privacy

    NARCIS (Netherlands)

    Lieshout, M.J. van; Kool, L.; Schoonhoven, B. van; Jonge, M. de

    2011-01-01

    Purpose: The purpose of this paper is to develop/elaborate the concept Privacy by Design (PbD) and to explore the validity of the PbD framework. Design/methodology/approach: Attention for alternative concepts, such as PbD, which might offer surplus value in safeguarding privacy, is growing. Using

  15. A Cascade Optimization Strategy for Solution of Difficult Multidisciplinary Design Problems

    Science.gov (United States)

    Patnaik, Surya N.; Coroneos, Rula M.; Hopkins, Dale A.; Berke, Laszlo

    1996-01-01

    A research project to comparatively evaluate 10 nonlinear optimization algorithms was recently completed. A conclusion was that no single optimizer could successfully solve all 40 problems in the test bed, even though most optimizers successfully solved at least one-third of the problems. We realized that improved search directions and step lengths, available in the 10 optimizers compared, were not likely to alleviate the convergence difficulties. For the solution of those difficult problems we have devised an alternative approach called cascade optimization strategy. The cascade strategy uses several optimizers, one followed by another in a specified sequence, to solve a problem. A pseudorandom scheme perturbs design variables between the optimizers. The cascade strategy has been tested successfully in the design of supersonic and subsonic aircraft configurations and air-breathing engines for high-speed civil transport applications. These problems could not be successfully solved by an individual optimizer. The cascade optimization strategy, however, generated feasible optimum solutions for both aircraft and engine problems. This paper presents the cascade strategy and solutions to a number of these problems.

  16. Innovative Solutions for Words with Emphasis: Alternative Methods of Braille Transcription

    Science.gov (United States)

    Kamei-Hannan, Cheryl

    2009-01-01

    The author of this study proposed two alternative methods for transcribing words with emphasis into braille and compared the use of the symbols for emphasis with the current braille code. The results showed that students were faster at locating words presented in one of the alternate formats, but that there was no difference in students' accuracy…

  17. Pedagogical Implications in the Thermal Analysis of Uniform Annular Fins: Alternative Analytic Solutions by Series.

    Science.gov (United States)

    Campo, Antonio; Rodriguez, Franklin

    1998-01-01

    Presents two alternative computational procedures for solving the modified Bessel equation of zero order: the Frobenius method, and the power series method coupled with a curve fit. Students in heat transfer courses can benefit from these alternative procedures; a course on ordinary differential equations is the only mathematical background that…

  18. Design of batch operations: Systematic methodology for generation and analysis of sustainable alternatives

    DEFF Research Database (Denmark)

    Carvalho, Ana; Matos, Henrique A.; Gani, Rafiqul

    2010-01-01

    The objective of this paper is to present a new methodology that is able to generate, screen and identify sustainable alternatives to continuous chemical processes as well as processes operating in the batch mode. The methodology generates the sustainable (design) alternatives by locating...... the operational, environmental, economical and safety related problems inherent in the process (batch or continuous). Alternatives that are more sustainable, compared to a reference, are generated and evaluated by addressing one or more of the identified problems. A decomposition technique as well as a set...... processes are described, highlighting the main differences between them. Through two case studies, the application of the methodology, to obtain sustainable design alternatives for batch plants, is highlighted....

  19. Total System Performance Assessment- License Appication Design Selection (LADS) Phase 1 Analysis for Post-Closure Ventilation (Design Alternative 3)

    Energy Technology Data Exchange (ETDEWEB)

    N. Erb

    1999-06-21

    The objective of this report is to evaluate the effect of potential changes to the TSPA-VA base case design on long-term repository performance. The design changes that are evaluated in this report include two configurations for post-closure ventilation. bow tie and open loop (Design Alternative 3 or D3). The following paragraphs briefly describe the motivation for evaluating post-closure ventilation. The bow tie configuration for post closure ventilation has been identified as a design alternative to the TSPA-VA base case model (CRWMS M&O, 1998a) that may provide improved performance by reducing the temperature and relative humidity within the waste package drifts. The bow tie configuration for post-closure ventilation is a closed-loop design. In this design. cross drifts are placed in pairs with each drift angling up on opposite sides of the repository. From the side, the cross drifts and side drifts form the shape of a bow tie. Movement of air through the system is driven by convective heating from the waste packages in the cross drifts. The open loop configuration is also being considered for its potential to improve post-closure performance of the repository. As with the bow tie configuration, the open loop is designed to decrease temperature and relative humidity within the waste package drifts. For the open loop configuration, air is drawn into the drifts from outside the mountain. The configuration for the repository with open-loop ventilation is similar to the base case repository design with a few added shafts to increase air flow through the drifts. This report documents the modeling assumptions and calculations conducted to evaluate the long-term performance of Design Alternative 3. The performance measure for this evaluation is dose rate. Results are presented that compare the dose-rate time histories with the new design alternatives to that for the TSPA-VA base case calculation (CRWMS M&O, 1998a).

  20. Multi-Criteria Analysis of Alternative Energy Supply Solutions to Public Nearly Zero Energy Buildings

    Directory of Open Access Journals (Sweden)

    Giedrius Šiupšinskas

    2013-12-01

    Full Text Available The article analyzes energy supply alternatives for modernised public nearly zero energy buildings. The paper examines alternative energy production systems such as heat pumps (air-water and ground-water, solar collectors, adsorption cooling, biomass boiler, solar photovoltaic, wind turbines and combinations of these systems. The simulation of the analysed building energy demand for different energy production alternatives has been performed using TRNSYS modelling software. In order to determine an optimal energy supply variant, the estimated results of energy, environmental, and economic evaluation have been converted into non-dimensional variables (3E using multi-criteria analysis.Article in Lithuanian

  1. Alternatives to antibiotics: a symposium on the challenges and solutions for animal production.

    Science.gov (United States)

    Seal, Bruce S; Lillehoj, Hyun S; Donovan, David M; Gay, Cyril G

    2013-06-01

    Antibiotics are one of the most important medical discoveries of the 20th century and will remain an essential tool for treating animal and human diseases in the 21st century. However, antibiotic resistance among bacterial pathogens and concerns over their extensive use in food animals has garnered global interest in limiting antibiotic use in animal agriculture. Yet, limiting the availability of medical interventions to prevent and control animal diseases on the farm will directly impact global food security and safety as well as animal and human health. Insufficient attention has been given to the scientific breakthroughs and novel technologies that provide alternatives to antibiotics. The objectives of the symposium 'Alternatives to Antibiotics' were to highlight promising research results and novel technologies that could potentially lead to alternatives to conventional antibiotics, and assess challenges associated with their commercialization, and provide actionable strategies to support development of alternative antimicrobials. The symposium focused on the latest scientific breakthroughs and technologies that could provide new options and alternative strategies for preventing and treating diseases of animals. Some of these new technologies have direct applications as medical interventions for human health, but the focus of the symposium was animal production, animal health and food safety during food-animal production. Five subject areas were explored in detail through scientific presentations and expert panel discussions, including: (1) alternatives to antibiotics, lessons from nature; (2) immune modulation approaches to enhance disease resistance and to treat animal diseases; (3) gut microbiome and immune development, health and diseases; (4) alternatives to antibiotics for animal production; and (5) regulatory pathways to enable the licensure of alternatives to antibiotics.

  2. The Design of Treatment Wetlands in the United Kingdom: Successes, Failures, and Alternative Approaches

    Institute of Scientific and Technical Information of China (English)

    SUN Guangzhi; ZHANG Guangxin

    2008-01-01

    Constructed wetland was first introduced into the United Kingdom in the middle of 1980s, following a visit by a group of scientist to Western Germany. In the past 2 decades, the applications of constructed wetlands in this country have expanded substantially, due to the demand for green technologies and rising cost of fossil fuel energies. This paper reported a statistical investigation of the performances of 78 horizontal flow wetlands, representatives of such system in the United Kingdom. Alternative design equations, based on organic matter removal efficiency, have been developed from Monod kinetics, and the accuracy and reliability of current and alternative design approaches have been examined.

  3. Designing Digital Preservation Solutions: A Risk Management-Based Approach

    Directory of Open Access Journals (Sweden)

    José Barateiro

    2010-07-01

    Full Text Available Digital preservation aims to keep digital objects accessible over long periods of time, ensuring the authenticity and integrity of these digital objects. In such complex environments, Risk Management is a key factor in assuring the normal behaviour of systems over time. Currently, the digital preservation arena commonly uses Risk Management concepts to assess repositories. In this paper, we intend to go further and propose a perspective where Risk Management can be used not only to assess existing solutions, but also to conceive digital preservation environments. Thus, we propose a Risk Management-based approach to design and assess digital preservation environments, including:• the definition of context and identification of strategic objectives to determine specific requirements and characterize which consequences are acceptable within the identified context;• the identification, analysis and evaluation of threats and vulnerabilities that may affect the normal behaviour of a specific business or the achievement of the goals and conformance to the requirements identified in the context characterization; and, • definition of actions to deal with the risks associated with the identified threats and vulnerabilities.We generalize and survey the main requirements, threats, vulnerabilities and techniques that can be applied in the scope of digital preservation.

  4. Evaluation of HiPHES convective reformer design alternatives. Phase 2, Final issue

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-01

    Phase I Stone & Webster presented three potential design configurations for a ceramic-tubed steam-methane reformer. These were the Tube-Within-a-Tube (TWIT) design, the Once-Through design, and the Monolith design. Although the TWIT design configuration appeared to be the most viable, the inclusion of a more detailed examination of design alternatives for the HiPHES reformer was deemed appropriate for the Phase II program. Of particular concern was the length of the ceramic tubes required for the TWIT design. To assist in this evaluation, Stone & Webster established a Development Team consisting of specialists in the areas of heat transfer, ceramic materials, exchanger design, vessel design, and potential users. Stone & Webster reviewed the critical areas of concern for a ceramic convective reformer, evaluated competing design configurations, and presented the results to the Development Team. This report presents Stone & Webster`s evaluations and the comments and recommendations of the Development Team. This effort comprised the majority of Task 1 of Phase II of Stone & Webster`s HiPHES project. The design review was executed in parallel with the material coupon screening tests at BP America. The goal of both tasks was to confirm the materials selection and reformer design configuration so that the conditions for the tube and joint tests to be conducted at Oak Ridge National Laboratory (ORNL) could be specified. The ORNL tests are intended to evaluate the reformer design configuration and materials of construction used for the reformer design in Phase II, and to be used in the demonstration unit in Phase III. The Task 1 (Evaluation of Alternative Reformer Designs) effort has identified a preferred design configuration for the proposed ceramic reformer. Additional engineering and material evaluation work is necessary before an operating prototype can be designed.

  5. An Alternative Solution to Https for Secure Access to Web Services

    Directory of Open Access Journals (Sweden)

    Cristina Livia Iancu

    2012-06-01

    Full Text Available This paper presents a solution for accessing web services in a light-secure way. Because the payload of the messages is not so sensitive, it is taken care only about protecting the user name and the password used for authentication and authorization into the web services system. The advantage of this solution compared to the common used SSL is avoiding the overhead related to the handshake and encryption, providing a faster response to the clients. The solution is intended for Windows machines and is developed using the latest stable Microsoft technologies.

  6. Analog circuit design a tutorial guide to applications and solutions

    CERN Document Server

    Williams, Jim

    2011-01-01

    * Covers the fundamentals of linear/analog circuit and system design to guide engineers with their design challenges. * Based on the Application Notes of Linear Technology, the foremost designer of high performance analog products, readers will gain practical insights into design techniques and practice. * Broad range of topics, including power management tutorials, switching regulator design, linear regulator design, data conversion, signal conditioning, and high frequency/RF design. * Contributors include the leading lights in analog design, Robert Dobkin, Jim Willia

  7. Developmental problems and their solution for the Space Shuttle main engine alternate liquid oxygen high-pressure turbopump: Anomaly or failure investigation the key

    Science.gov (United States)

    Ryan, R.; Gross, L. A.

    1995-01-01

    The Space Shuttle main engine (SSME) alternate high-pressure liquid oxygen pump experienced synchronous vibration and ball bearing life problems that were program threatening. The success of the program hinged on the ability to solve these development problems. The design and solutions to these problems are engirded in the lessons learned and experiences from prior programs, technology programs, and the ability to properly conduct failure or anomaly investigations. The failure investigation determines the problem cause and is the basis for recommending design solutions. For a complex problem, a comprehensive solution requires that formal investigation procedures be used, including fault trees, resolution logic, and action items worked through a concurrent engineering-multidiscipline team. The normal tendency to use an intuitive, cut-and-try approach will usually prove to be costly, both in money and time and will reach a less than optimum, poorly understood answer. The SSME alternate high-pressure oxidizer turbopump development has had two complex problems critical to program success: (1) high synchronous vibrations and (2) excessive ball bearing wear. This paper will use these two problems as examples of this formal failure investigation approach. The results of the team's investigation provides insight into the complexity of the turbomachinery technical discipline interacting/sensitivities and the fine balance of competing investigations required to solve problems and guarantee program success. It is very important to the solution process that maximum use be made of the resources that both the contractor and Government can bring to the problem in a supporting and noncompeting way. There is no place for the not-invented-here attitude. The resources include, but are not limited to: (1) specially skilled professionals; (2) supporting technologies; (3) computational codes and capabilities; and (4) test and manufacturing facilities.

  8. Alternatives generation and analysis for the Phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Claghorn, R.D., Fluor Daniel Hanford

    1997-02-06

    This alternatives generation and analysis (AGA) addresses the question: What is the design basis for the facilities required to stage low-level waste (LLW) feed to the Phase I private contractors? Alternative designs for the intermediate waste feed staging system were developed, analyzed, and compared. Based on these analyses, this document recommends installing mixer pumps in the central pump pit of double-shell tanks 241-AP-102 and 241-AP-104. Also recommended is installing decant/transfer pumps at these tanks. These recommendations have clear advantages in that they provide a low shedule impact/risk and the highest operability of all the alternatives investigated. This revision incorporates comments from the decision board.

  9. At-Risk Students' Perceptions of Traditional Schools and a Solution-Focused Public Alternative School

    Science.gov (United States)

    Lagana-Riordan, Christine; Aguilar, Jemel P.; Franklin, Cynthia; Streeter, Calvin L.; Kim, Johnny S.; Tripodi, Stephen J.; Hopson, Laura M.

    2011-01-01

    Recent trends in education have drawn attention to students at risk of school failure and dropout in the United States. Alternative schools are one method for preventing the severe and long-lasting consequences of underachievement and dropout. Few research studies have sought the opinions and perceptions of the at-risk students who attend…

  10. BOOST QUALITY OF ENGINEERING PROJECT SOLUTIONS THROUGH ECONOMIC ANALYSIS AND COMPARING ALTERNATIVES

    Directory of Open Access Journals (Sweden)

    Milan Vukčević

    2008-12-01

    Full Text Available In this paper the principles and applications of money-time relationships are given. Economic profitability of engineering projects, using more methodes is analised. On the bases those methodes, comparing mutually exclusive alternatives of projects was done, because of optimization of decision. The emphasized theoretical states in this paper are applicated.

  11. Wake fields in the LHCb vertex detector : alternative designs for the wake field suppressor

    CERN Document Server

    Van Bakel, N; Ferro-Luzzi, M

    2000-01-01

    Two previous LHCb notes showed that wake field suppressors are needed to prevent dissipating excessive power in resonating modes of the vertex detector components. This note concentrates on two different designs of the encapsulations of the silicon detectors which can serve as an alternative to the design which uses long thin strips spanned throughout the vertex detector near the beam axis. The quality of wake field suppression with respect to the depth of a corrugated structure is simulated.

  12. Long-term strategies for flood risk management: scenario definition and strategic alternative design

    NARCIS (Netherlands)

    Bruijn, de K.; Klijn, F.; McGahey, C.; Mens, M.; Wolfert, H.P.

    2008-01-01

    This report reviews some mainstream existing methods of scenario development and use, as well as experiences with the design and assessment of strategic alternatives for flood risk management. Next, a procedure and methods are proposed and discussed. Thirdly, the procedure and methods are tried on t

  13. Single-Case Research Design: An Alternative Strategy for Evidence-Based Practice

    Science.gov (United States)

    Stapleton, Drue; Hawkins, Andrew

    2015-01-01

    Objective: The trend of utilizing evidence-based practice (EBP) in athletic training is now requiring clinicians, researchers, educators, and students to be equipped to both engage in and make judgments about research evidence. Single-case design (SCD) research may provide an alternative approach to develop such skills and inform clinical and…

  14. Long-term strategies for flood risk management: scenario definition and strategic alternative design

    NARCIS (Netherlands)

    Bruijn, de K.; Klijn, F.; McGahey, C.; Mens, M.; Wolfert, H.P.

    2008-01-01

    This report reviews some mainstream existing methods of scenario development and use, as well as experiences with the design and assessment of strategic alternatives for flood risk management. Next, a procedure and methods are proposed and discussed. Thirdly, the procedure and methods are tried on t

  15. Long-term strategies for flood risk management: scenario definition and strategic alternative design

    NARCIS (Netherlands)

    Bruijn, de K.; Klijn, F.; McGahey, C.; Mens, M.; Wolfert, H.P.

    2008-01-01

    This report reviews some mainstream existing methods of scenario development and use, as well as experiences with the design and assessment of strategic alternatives for flood risk management. Next, a procedure and methods are proposed and discussed. Thirdly, the procedure and methods are tried on

  16. Single-Case Research Design: An Alternative Strategy for Evidence-Based Practice

    Science.gov (United States)

    Stapleton, Drue; Hawkins, Andrew

    2015-01-01

    Objective: The trend of utilizing evidence-based practice (EBP) in athletic training is now requiring clinicians, researchers, educators, and students to be equipped to both engage in and make judgments about research evidence. Single-case design (SCD) research may provide an alternative approach to develop such skills and inform clinical and…

  17. Alternative Instructional Design Paradigms: What's Worth Discussing and What Isn't.

    Science.gov (United States)

    Willis, Jerry

    1998-01-01

    Examines the paradigm debate over established (behavioral and cognitive) and alternative (constructivist) models of instructional design (ID). Discusses instructional strategies and principles, new terms versus new meaning, "straw man" and personalized arguments, expert-determined goals, research-based versus "brand-X" models,…

  18. Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?

    Institute of Scientific and Technical Information of China (English)

    Lai Wei; Koichiro Hata; Benedict Marie Doorschodt; Reinhard Büttner; Thomas Minor; René H Tolba

    2007-01-01

    AIM: To evaluate the potential of Polysol, a newly developed preservation solution, in cold storage of small bowel grafts, compared with the current standards,University of Wisconsin solution (UW), Celsior and histidine-tryptophan-ketoglutarate solution (HTK).METHODS: Male Wistar rats were used as donors.Small bowels were retrieved, flushed and then stored in the respective 4 solutions for 18 h at 4℃. Functional integrity of the grafts was evaluated by isolated reperfusion with oxygenated Krebs-Henseleit buffer at 37℃ for 30 min in all 4 groups.RESULTS: Polysol preservation exhibited the highest tissue ATP concentration and the lowest release of LDH.Malondialdehyde, an index for tissue lipid peroxidation,was also the lowest in Polysol. Tissue oxygen consumption was significantly higher in Polysol than in the others. Of interest, UW-storage promoted 10-fold higher apoptosis than in the others. Moreover, electron microscopy revealed that the mucosal villi/micro-villi formation and the cell organelles, including mitochondria,were both significantly better preserved in Polysol, while deleterious alterations were apparent in the others, most notably in UW. Although Celsior and HTK exhibited the better trend of results than UW in some parameters, but could not reach the over-all superiority to UW.CONCLUSION: Cold storage using Polysol resulted in significantly better integrity and function of small bowel grafts than UW. Hence, Polysol may be a novel alternative for the small bowel preservation.

  19. Successful Design of Learning Solutions Being Situation Aware

    Science.gov (United States)

    Niemelä, Pia; Isomöttönen, Ville; Lipponen, Lasse

    2016-01-01

    Education is increasingly enhanced by technology, and at the same time, the rapid pace of technology innovation and growing demand of consumers introduces challenges for providers of technological learning solutions. This paper investigates Finnish small and medium size companies who either develop or deliver technological solutions for education.…

  20. Successful Design of Learning Solutions Being Situation Aware

    Science.gov (United States)

    Niemelä, Pia; Isomöttönen, Ville; Lipponen, Lasse

    2016-01-01

    Education is increasingly enhanced by technology, and at the same time, the rapid pace of technology innovation and growing demand of consumers introduces challenges for providers of technological learning solutions. This paper investigates Finnish small and medium size companies who either develop or deliver technological solutions for education.…

  1. A comparison of alternative 60-mer probe designs in an in-situ synthesized oligonucleotide microarray

    Directory of Open Access Journals (Sweden)

    Fairbanks Benjamin D

    2006-04-01

    Full Text Available Abstract Background DNA microarrays have proven powerful for functional genomics studies. Several technologies exist for the generation of whole-genome arrays. It is well documented that 25mer probes directed against different regions of the same gene produce variable signal intensity values. However, the extent to which this is true for probes of greater length (60mers is not well characterized. Moreover, this information has not previously been reported for whole-genome arrays designed against bacteria, whose genomes may differ substantially in characteristics directly affecting microarray performance. Results We report here an analysis of alternative 60mer probe designs for an in-situ synthesized oligonucleotide array for the GC rich, β-proteobacterium Burkholderia cenocepacia. Probes were designed using the ArrayOligoSel3.5 software package and whole-genome microarrays synthesized by Agilent, Inc. using their in-situ, ink-jet technology platform. We first validated the quality of the microarrays as demonstrated by an average signal to noise ratio of >1000. Next, we determined that the variance of replicate probes (1178 total probes examined of identical sequence was 3.8% whereas the variance of alternative probes (558 total alternative probes examined designs was 9.5%. We determined that depending upon the definition, about 2.4% of replicate and 7.8% of alternative probes produced outlier conclusions. Finally, we determined none of the probe design subscores (GC content, internal repeat, binding energy and self annealment produced by ArrayOligoSel3.5 were predictive or probes that produced outlier signals. Conclusion Our analysis demonstrated that the use of multiple probes per target sequence is not essential for in-situ synthesized 60mer oligonucleotide arrays designed against bacteria. Although probes producing outlier signals were identified, the use of ratios results in less than 10% of such outlier conclusions. We also determined that

  2. Alternate MIMO AF relaying networks with interference alignment: Spectral efficient protocol and linear filter design

    KAUST Repository

    Park, Kihong

    2013-02-01

    In this paper, we study a two-hop relaying network consisting of one source, one destination, and three amplify-and-forward (AF) relays with multiple antennas. To compensate for the capacity prelog factor loss of 1/2$ due to the half-duplex relaying, alternate transmission is performed among three relays, and the inter-relay interference due to the alternate relaying is aligned to make additional degrees of freedom. In addition, suboptimal linear filter designs at the nodes are proposed to maximize the achievable sum rate for different fading scenarios when the destination utilizes a minimum mean-square error filter. © 1967-2012 IEEE.

  3. Alternative Muon Front-end for the International Design Study (IDS)

    CERN Document Server

    Alekou, A; Martini, M; Prior, G; Rogers, C; Stratakis, D; Yoshikawa, C; Zisman, M

    2010-01-01

    We discuss alternative designs of the muon capture front end of the Neutrino Factory International Design Study (IDS). In the front end, a proton bunch on a target creates secondary pions that drift into a capture channel, decaying into muons. A sequence of RF cavities forms the resulting muon beams into strings of bunches of differing energies, aligns the bunches to (nearly) equal central energies, and initiates ionization cooling. This design is affected by limitations on accelerating gradients within magnetic fields. The effects of gradient limitations are explored, and mitigation strategies are presented

  4. New design solutions for low-power energy production in water pipe systems

    Directory of Open Access Journals (Sweden)

    Helena M. RAMOS

    2009-12-01

    Full Text Available This study is the result of ongoing research for a European Union 7th Framework Program Project regarding energy converters for very low heads, and aims to analyze optimization of new cost-effective hydraulic turbine designs for possible implementation in water supply systems (WSSs or in other pressurized water pipe infrastructures, such as irrigation, wastewater, or drainage systems. A new methodology is presented based on a theoretical, technical and economic analysis. Viability studies focused on small power values for different pipe systems were investigated. Detailed analyses of alternative typical volumetric energy converters were conducted on the basis of mathematical and physical fundamentals as well as computational fluid dynamics (CFD associated with the interaction between the flow conditions and the system operation. Important constraints (e.g., size, stability, efficiency, and continuous steady flow conditions can be identified and a search for alternative rotary volumetric converters is being conducted. As promising cost-effective solutions for the coming years, adapted rotor-dynamic turbomachines and non-conventional axial propeller devices were analyzed based on the basic principles of pumps operating as turbines, as well as through an extensive comparison between simulations and experimental tests.

  5. The implementation limitations of and alternative policy solutions for Indonesia's REDD+ program concerning peatland restoration

    Directory of Open Access Journals (Sweden)

    Sarah Guzick

    2013-07-01

    Full Text Available Recent increases in global demand for palm oil have resulted in rapid, widespread deforestation in Indonesia, making Indonesia the third largest emitter of greenhouse gases in the world. Although the Indonesian government has sought to pursue progressive environmental policies to curb deforestation, such as through REDD+, implementation has been hampered by legal loopholes, corruption and weak rule of law. This paper will examine two alternative carbon sequestration policies to REDD+: a drying up of the palm oil market and a buy-out of palm oil plantations.

  6. RISK AND PROFI TABILITY OF ISLAMIC BANKS: A RELIGIOUS DECEPTION OR AN ALTERNATIVE SOLUTION?

    OpenAIRE

    Trad, Naama; Trabelsi, Mohamed Ali; Goux, Jean François

    2017-01-01

    The aim of this paper is to examine whether Islamic finance could be an alternative to the traditional financial system and could guarantee stability in times of crisis. To this end, 78 Islamic banks in 12 countries have been studied over the 2004–2013 period. A series of bank-specific and other country specific indicators are combined to explain the soundness of Islamic banking in terms of profitability as measured by ROA and ROE, and risk divided into credit risk measured by IMLGL and EQL, ...

  7. BIOADSORPTION USING COMPOST: AN ALTERNATIVE FOR REMOVAL OF CHROMIUM (VI FROM AQUEOUS SOLUTIONS

    Directory of Open Access Journals (Sweden)

    Claudia Vargas,

    2012-05-01

    Full Text Available The removal of Cr(VI from aqueous solutions was studied using a compost generated from carnation flowers waste. The highest percentage of removal achieved (ca. 99 % was obtained at pH 2.0, using a 10 mg L-1 of Cr(VI solution, a dose of 10 g L-1 of compost, and with an equilibrium time of 3 hours. Under these conditions, the kinetics and adsorption isotherm were examined varying the initial Cr(VI concentration from 15 to 200 mg L-1. The maximum sorption capacity at equilibrium (Qm, from the Langmuir model, was found to be 6.25 mg g-1. The evaluation of Cr(VI removal at pH 2.0 showed a second order kinetics and showed that the process mechanism can be modeled by the “adsorption-coupled reduction” hypothesis. Also, the monitoring of Cr(VI and total Cr in aqueous solutions showed that Cr(VI and total Cr were removed from solution, and that part of the Cr(III was retained on the compost. According to the results, the removal of Cr(VI with the assayed compost can be explained by the following steps: (i adsorption of Cr(VI species onto compost, (ii Cr(VI reduction to Cr(III, and (iii adsorption of part of Cr(III on the compost. Thus, this study suggests that the carnation flower waste compost can be used as a remediation system for water contaminated with Cr(VI.

  8. Army Gas-Cooled Reactor Systems program: alternator final design report

    Energy Technology Data Exchange (ETDEWEB)

    1964-06-01

    The development and testing of a demonstration brushless alternator for the ML-1 mobile nuclear power plant is described. The brushless concept was selected after it became apparent that a conventional power generator could not satisfy the ML-1 weight and size requirements. The demonstration alternator fabricated and tested under this program did not meet all performance specifications; the efficiency was low and the unit could not be operated for significant periods of time without overheating. However, a large body of useful data was accumulated during the extensive development program. Of special interest are data on the rotor and stator design, the cooling requirements and on the distribution of eddy current losses. Analysis of the data indicates that a brushless alternator, only slightly larger and heavier than was specified for the ML-1, could be developed with a modest additional effort.

  9. The Top 10 Facility Design and Planning Solutions.

    Science.gov (United States)

    Kennedy, Mike

    2001-01-01

    Discussses the top issues facing schools as they build and renovate their facilities to meet the educational needs of the 21st Century. Issues include alternative school sites, ecologically friendly facilities, flexible spaces, outdoor spaces, schools as communities, smaller schools, security, technology, and school/community relationships. (GR)

  10. Disruptive images: stimulating creative solutions by visualizing the design vision

    NARCIS (Netherlands)

    Eggink, Wouter; Kivacevic, A.; Ion, W.; McMahon, C.; Buck, C.; Hogarth, P.

    2011-01-01

    In a contemporary design context it is important to be able to communicate design strategy at a high abstraction level and at an early stage in the design process. At the same time, in our postmodern consumer society that is largely dominated by media, it is important to be able to communicate ideas

  11. Disruptive images: stimulating creative solutions by visualizing the design vision

    NARCIS (Netherlands)

    Eggink, Wouter; Kivacevic, A.; Ion, W.; McMahon, C.; Buck, C.; Hogarth, P.

    2011-01-01

    In a contemporary design context it is important to be able to communicate design strategy at a high abstraction level and at an early stage in the design process. At the same time, in our postmodern consumer society that is largely dominated by media, it is important to be able to communicate ideas

  12. Alternating irrigation water quality as a method to control solute concentrations and mass fluxes below irrigated fields: A numerical study

    Science.gov (United States)

    Russo, David

    2016-05-01

    The aim of the present numerical study was to extend the data-driven protocol for the control of soil salinity, to control chloride and nitrate concentrations and mass fluxes below agricultural fields irrigated with treated waste water (TWW). The protocol is based on alternating irrigation water quality between TWW and desalinized water (DSW), guided by solute concentrations at soil depth, zs. Two different schemes, the first requires measurements of soil solution concentrations of chloride and nitrate at zs, while, the second scheme requires only measurements of soil solution EC at zs, were investigated. For this purpose, 3-D numerical simulations of flow and transport were performed for variably saturated, spatially heterogeneous, flow domains located at two different field sites. The sites differ in crop type, irrigation method, and in their lithology; these differences, in turn, considerably affect the performance of the proposed schemes, expressed in terms of their ability to reduce solute concentrations that drained below the root zone. Results of the analyses suggest that the proposed data-driven schemes allow the use of low-quality water for irrigation, while minimizing the consumption of high-quality water to a level, which, for given climate, soil, crop, irrigation method, and water quality, may be determined by the allowable nitrate and chloride concentrations in the groundwater. The results of the present study indicate that with respect to the diminution of groundwater contamination by chloride and nitrate, the more data demanding, first scheme is superior the second scheme.

  13. Performance of R-410A Alternative Refrigerants in a Reciprocating Compressor Designed for Air Conditioning Applications

    Energy Technology Data Exchange (ETDEWEB)

    Shrestha, Som S [ORNL; Vineyard, Edward Allan [ORNL; Mumpower, Kevin [Bristol Compressors International, Inc.

    2016-01-01

    In response to environmental concerns raised by the use of refrigerants with high Global Warming Potential (GWP), the Air-Conditioning, Heating, and Refrigeration Institute (AHRI) has launched an industry-wide cooperative research program, referred to as the Low-GWP Alternative Refrigerants Evaluation Program (AREP), to identify and evaluate promising alternative refrigerants for major product categories. After successfully completing the first phase of the program in December 2013, AHRI launched a second phase of the Low-GWP AREP in 2014 to continue research in areas that were not previously addressed, including refrigerants in high ambient conditions, refrigerants in applications not tested in the first phase, and new refrigerants identified since testing for the program began. Although the Ozone Depletion Potential of R-410A is zero, this refrigerant is under scrutiny due to its high GWP. Several candidate alternative refrigerants have already demonstrated low global warming potential. Performance of these low-GWP alternative refrigerants is being evaluated for Air conditioning and heat pump applications to ensure acceptable system capacity and efficiency. This paper reports the results of a series of compressor calorimeter tests conducted for the second phase of the AREP to evaluate the performance of R-410A alternative refrigerants in a reciprocating compressor designed for air conditioning systems. It compares performance of alternative refrigerants ARM-71A, L41-1, DR-5A, D2Y-60, and R-32 to that of R-410A over a wide range of operating conditions. The tests showed that, in general, cooling capacities were slightly lower (except for the R-32), but energy efficiency ratios (EER) of the alternative refrigerants were comparable to that of R-410A.

  14. Northern Regions of Russia as Alternative Sources of Pure Water for Sustainable Development: Challenges and Solutions

    Science.gov (United States)

    Tsukerman, V. A.; Gudkov, A. V.; Ivanov, S. V.

    The paper discusses problems associated with the existing crisis of water scarcity in the modern conditions of the global water use. Available alternative sources of fresh water may be underground and surface waters of the North and the Arctic. Investigated the current situation and condition of fresh water resources in the technological and industrial development of the North and Arctic. The necessity of developing and using green technologies and measures to prevent pollution of surface and ground water from industrial sectors of the Northern regions is shown. Studied modern technologies and techniques for monitoring groundwater and determination of their age in order to avoid and prevent the effects of environmental contaminants. The ways of use of innovative production technologies of fresh and clean water of north Russia for sustainable development, and delivery of water in the needy regions of the world are investigated.

  15. Methodology for assessing the impacts of alternative rate designs on industrial energy use. Draft report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-01-11

    A task was undertaken to develop a method for analyzing industrial user responses to alternative rate designs. The method described considers the fuel switching and conservation responses of industrial users and the impact to a hypothetical utility regarding revenue stability, annual gas demand, and seasonal fluctuations. Twenty-seven hypothetical industrial plant types have been specified. For each combustor in the plant, the fuel consumption by season, initial fuel type, fuel switching costs, conservation costs, and amount of fuel conservable is provided. The decision making takes place at the plant level and is aggregated to determine the impact to the utility. Section 2 discusses the factors affecting an industrial user's response to alternative rate designs. Section 3 describes the methodology, includes an overview of the model and an example industrial user's response to a set of fuel prices. The data describing the 27 hypothetical firms is in an appendix.

  16. A new alternative adsorbent for the removal of cationic dyes from aqueous solution

    Directory of Open Access Journals (Sweden)

    T. Santhi

    2016-09-01

    Full Text Available Adsorption of Malachite green (MG and Methylene blue (MB from aqueous solutions on low cost adsorbent prepared from Annona squmosa seed (CAS is studied experimentally. Results obtained indicate that the removal efficiency of Malachite green and Methylene blue at 27 ± 2 °C exceeds 75.66% and 24.33% respectively, and that the adsorption process is highly pH-dependent. Results showed that the optimum pH for dye removal is 6.0. The amount of dye adsorbed from aqueous solution increases with the increase of the initial dye concentration. Smaller adsorbent particle adds to increase the percentage removal of Malachite green and Methylene blue. The equilibrium data fitted well to the Langmuir model (R2 > 0.97 and the adsorption kinetic followed the pseudo-second-order equation (R2 > 0.99. The maximum adsorption capacities of MG, MB on CAS are 25.91 mg g−1 and 08.52 mg g−1 respectively. These results suggest that A. squmosa seed is a potential low-cost adsorbent for the dye removal from industrial wastewater. The adsorption capacity of CAS on MG is greater than MB.

  17. Standard practice for exposure of metals and alloys by alternate immersion in neutral 3.5% Sodium Chloride solution

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    1999-01-01

    1.1 This practice covers procedures for making alternate immersion stress corrosion tests in 3.5 % sodium chloride (NaCl) (). It is primarily for tests of aluminum alloys (Test Method G 47) and ferrous alloys, but may be used for other metals exhibiting susceptibility to chloride ions. It sets forth the environmental conditions of the test and the means for controlling them. Note 1 Alternate immersion stress corrosion exposures are sometimes made in substitute ocean water (without heavy metals) prepared in accordance with Specification D 1141. The general requirements of this present practice are also applicable to such exposures except that the reagents used, the solution concentration, and the solution pH should be as specified in Specification D 1141. 1.2 This practice can be used for both stressed and unstressed corrosion specimens. Historically, it has been used for stress-corrosion cracking testing, but is often used for other forms of corrosion, such as uniform, pitting, intergranular, and galvanic. ...

  18. 40 CFR 72.26 - Delegation by designated representative and alternate designated representative.

    Science.gov (United States)

    2010-07-01

    ... designated representative may delegate, to one or more natural persons, his or her authority to make an... representative may delegate, to one or more natural persons, his or her authority to make an electronic... this part and parts 73 through 77 of this chapter. (c) In order to delegate authority to make an...

  19. SUSTAINABLE ALLOY DESIGN: SEARCHING FOR RARE EARTH ELEMENT ALTERNATIVES THROUGH CRYSTAL ENGINEERING

    Science.gov (United States)

    2016-02-26

    Force Base, Dayton OH, March 20th 2013 23. Informatics Aided Discovery of Energy Materials 2013 Kentucky Workshop on Renewable Energy and Energy ...AFRL-AFOSR-VA-TR-2016-0122 Sustainable Alloy Design Searching for Rare Earth Element Alternatives through Crystal Engineering Krishna Rajan IOWA...reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching

  20. Increasing spelling achievement: an analysis of treatment procedures utilizing an alternating treatments design.

    OpenAIRE

    Ollendick, T. H.; Matson, J L; Esveldt-Dawson, K; Shapiro, E S

    1980-01-01

    Two studies which examine the effectiveness of spelling remediation procedures are reported. In both studies, an alternating treatment design was employed. In the first study, positive practice overcorrection plus positive reinforcement was compared to positive practice alone and a no-remediation control condition. In the second study, positive practice plus positive reinforcement was compared to a traditional corrective procedure plus positive reinforcement and a traditional procedure when u...

  1. Predicting the effectiveness of road safety campaigns through alternative research designs.

    Science.gov (United States)

    Adamos, Giannis; Nathanail, Eftihia

    2016-12-01

    A large number of road safety communication campaigns have been designed and implemented in the recent years; however their explicit impact on driving behavior and road accident rates has been estimated in a rather low proportion. Based on the findings of the evaluation of three road safety communication campaigns addressing the issues of drinking and driving, seat belt usage, and driving fatigue, this paper applies different types of research designs (i.e., experimental, quasi-experimental, and non-experimental designs), when estimating the effectiveness of road safety campaigns, implements a cross-design assessment, and conducts a cross-campaign evaluation. An integrated evaluation plan was developed, taking into account the structure of evaluation questions, the definition of measurable variables, the separation of the target audience into intervention (exposed to the campaign) and control (not exposed to the campaign) groups, the selection of alternative research designs, and the appropriate data collection methods and techniques. Evaluating the implementation of different research designs in estimating the effectiveness of road safety campaigns, results showed that the separate pre-post samples design demonstrated better predictability than other designs, especially in data obtained from the intervention group after the realization of the campaign. The more constructs that were added to the independent variables, the higher the values of the predictability were. The construct that most affects behavior is intention, whereas the rest of the constructs have a lower impact on behavior. This is particularly significant in the Health Belief Model (HBM). On the other hand, behavioral beliefs, normative beliefs, and descriptive norms, are significant parameters for predicting intention according to the Theory of Planned Behavior (TPB). The theoretical and applied implications of alternative research designs and their applicability in the evaluation of road safety

  2. Mind Wandering "Ahas" versus Mindful Reasoning: Alternative Routes to Creative Solutions

    Directory of Open Access Journals (Sweden)

    Claire M Zedelius

    2015-06-01

    Full Text Available Based on mixed results linking both mindfulness and its opposing construct mind wandering to enhanced creativity, we predicted that the relationship between mindfulness and creativity might depend on whether creative problems are approached through analytic strategy or through insight (i.e., sudden awareness of a solution. Study 1 investigated the relationship between trait mindfulness and compound remote associates problem solving as a function of participants’ self-reported approach to each problem. The results revealed a negative relationship between mindfulness and problem-solving overall. However, more detailed analysis revealed that mindfulness was associated with impaired problem solving when approaching problems with insight, but increased problem solving when using analysis. In Study 2, we manipulated participants’ problem-solving approach through instructions. We again found a negative relationship between mindfulness and creative performance in general, however, more mindful participants again performed better when instructed to approach problems analytically.

  3. [Case report - Intraosseous infusion as an alternative solution in the therapy of septicaemia in an adult].

    Science.gov (United States)

    Lingner, Manuel; Niederer, Oliver; Majolk, Jürgen; Krombholz, Karsten

    2014-02-01

    The intraosseous access can be more often found in the guidelines and recommendations of the medical societies when an peripheral or central venous catheter cannot be established. For the adult this can mostly be found for the cardiopulmonary resuscitation or the patient with major trauma. In pediatrics and neonatology it is a reliable solution for the child in septic shock. In our case a 36 year old presented with an endocarditis and tricuspid valve insufficiency III° by known intravenous drug-abuse and septic shock. It was initially impossible to establish an adequate peripheral or central venous catheter. For this reason a humeral intraosseous access was established. After stabilizing circulatory function and volume replacement a central-venous catheter could be placed and the patient was successfully surgically sanified. We used the EZ-IO((Vidacare Corporation, San Antonio/USA). Appropriate systems should extensively be available in the clinical setting.

  4. DOE/ORNL heat pump design model, overview and application to R-22 alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Rice, C.K.

    1997-12-01

    This computer program is a public-domain system design tool for application to air-to-air heat pumps. The main aspects of the program are reviewed with emphasis on the newest features of the current fifth-generation version (Mark V) and an upcoming more fully HFC-capable release (Mark VI). Current model predictions are compared to test data for a leading HFC alternative to HCFC-22 in heat pumps. Examples are shown of some user interfaces that have been recently developed for the program. To demonstrate the design capabilities of the model for R-22 alternatives, a refrigerant-side optimization was conducted to find the best balance of heat transfer versus pressure drop for HCFC R-22, HFCs R-134a and R-410A, and the natural refrigerant propane. COP was maximized while refrigerant charge and tube size were minimized. Independent design parameters were fraction of total area in the outdoor coil, tube diameter and number of circuits for each heat exchanger, and condenser subcooling. Heat exchanger design tradeoffs are discussed for a heat pump relative to air conditioners and heating-only units. A design optimized for heating-only operation is presented.

  5. A Solution to Knowledge Management in Networked Collaborative Design

    Institute of Scientific and Technical Information of China (English)

    WENYue-jie; TIANLing; TONGBing-shu

    2004-01-01

    Concerning the demands in networked collaborative innovative design, a knowledge-based collaborative design model is introduced the model of knowledge integration along with its relevant supporting techniques are presented. After illustrating the general knowledge search paradigm, a kind of dynamic user model is proposed to improve knowledge search efficiency. At last a short introduction of the system's implementation is described.

  6. RISK AND PROFI TABILITY OF ISLAMIC BANKS: A RELIGIOUS DECEPTION OR AN ALTERNATIVE SOLUTION?

    Directory of Open Access Journals (Sweden)

    Trad, Naama

    2017-01-01

    Full Text Available The aim of this paper is to examine whether Islamic finance could be an alternative to the traditional financial system and could guarantee stability in times of crisis. To this end, 78 Islamic banks in 12 countries have been studied over the 2004–2013 period. A series of bank-specific and other country specific indicators are combined to explain the soundness of Islamic banking in terms of profitability as measured by ROA and ROE, and risk divided into credit risk measured by IMLGL and EQL, and insolvency risk measured by Z-SCORE. The aim is to estimate five regressions using dynamic panel data econometrics (GMM system. The results indicate that bank size and capital are the main factors responsible for increasing profitability and stability of Islamic banks and reducing their credit risk. However, the ratios forming the variable liquidity and asset quality often lead to inconclusive results. It is also found that macroeconomic variables, except inflation, are able to improve Islamic banks’ stability. This is not the case for credit risk where the ratio is still unfavorable. The conclusion is that there are no major differences between IBs and CBs in terms of their profitability and risk features.

  7. Cloud Computing as an Alternative IT Solution for SMEs: A System Dynamic Approach

    Directory of Open Access Journals (Sweden)

    Mochamad Arief Abdillah

    2014-12-01

    Full Text Available Small medium enterprises (SMEs play a big role for GDP in Indonesia. In 2012, SMEs made contribution 59,08 % for GDP Indonesia. The amount of SMEs in Indonesia is 99,99 % from total company in Indonesia. From that data, we know that SMEs is very big market in Indonesia. However, despite many big contributions that SMEs gave, SMEs also have challenges for themselves. The limitation of capital is one of challenges that SMEs have to face. The limit of capital make SMEs spend their capital wisely. They have to think very carefully how to expand their business. Is it profitable or not. In this paper we want to understand about the phenomenon why SMEs are hard to implement information and system technology. We used observation and secondary data to construct the variables. After that, we use the variables to build the model using system dynamics. And then we simulate it to know the impact implementation of information technology to flow business of SMEs. To propose new alternative technology (cloud computing, we modified the variables in the model and simulated it. We compared the result between own information technology and cloud computing. The result shows that cloud computing is suitable to be implemented in SMEs.Keywords : Cloud computing, SME, System Dynamic, Information Technology, Model

  8. Gasification: An alternative solution for energy recovery and utilization of vegetable market waste.

    Science.gov (United States)

    Narnaware, Sunil L; Srivastava, Nsl; Vahora, Samir

    2017-03-01

    Vegetables waste is generally utilized through a bioconversion process or disposed of at municipal landfills, dumping sites or dumped on open land, emitting a foul odor and causing health hazards. The presents study deals with an alternative way to utilize solid vegetable waste through a thermochemical route such as briquetting and gasification for its energy recovery and subsequent power generation. Briquettes of 50 mm diameter were produced from four different types of vegetable waste. The bulk density of briquettes produced was increased 10 to 15 times higher than the density of the dried vegetable waste in loose form. The lower heating value (LHV) of the briquettes ranged from 10.26 MJ kg(-1) to 16.60 MJ kg(-1) depending on the type of vegetable waste. The gasification of the briquettes was carried out in an open core downdraft gasifier, which resulted in syngas with a calorific value of 4.71 MJ Nm(-3) at the gasification temperature between 889°C and 1011°C. A spark ignition, internal combustion engine was run on syngas and could generate a maximum load up to 10 kWe. The cold gas efficiency and the hot gas efficiency of the gasifier were measured at 74.11% and 79.87%, respectively. Energy recovery from the organic vegetable waste was possible through a thermochemical conversion route such as briquetting and subsequent gasification and recovery of the fuel for small-scale power generation.

  9. Designing, developing, and facilitating smart cities urban design to IoT solutions

    CERN Document Server

    Tragos, Elias; Pöhls, Henrich; Kapovits, Adam; Bassi, Alessandro

    2017-01-01

    This book discusses how smart cities strive to deploy and interconnect infrastructures and services to guarantee that authorities and citizens have access to reliable and global customized services. The book addresses the wide range of topics present in the design, development and running of smart cities, ranging from big data management, Internet of Things, and sustainable urban planning. The authors cover - from concept to practice – both the technical aspects of smart cities enabled primarily by the Internet of Things and the socio-economic motivations and impacts of smart city development. The reader will find smart city deployment motivations, technological enablers and solutions, as well as state of the art cases of smart city implementations and services. · Provides a single compendium of the technological, political, and social aspects of smart cities; · Discusses how the successful deployment of smart Cities requires a unified infrastructure to support the diverse set of applications that can be ...

  10. Alternate Spray-coating for the Direct Fabrication of Hydroxyapatite Films without Crystal Growth Step in Solution.

    Science.gov (United States)

    Watanabe, Satoshi; Kashiwagi, Rei; Matsumoto, Mutsuyoshi

    2017-03-01

    We discuss an alternate spray-coating technique for the direct fabrication of hydroxyapatite films using metal masks, suction-type spray nozzles and two calcification solutions of calcium hydroxide and phosphoric acid aqueous solutions. Hydroxyapatite films were formed only on the hydrophobic surface of the substrates. Scanning electron microscopy and energy dispersive X-ray spectroscopy showed that the spray-coated films consisted of hydroxyapatite nanoparticles. The Ca/P ratio was estimated to be about 1.26. X-ray diffraction patterns of the spray-coated films almost coincided with those of the hydroxyapatite powders, showing that the spray-coated films consisted of hydroxyapatite nanoparticles. Dot arrays of hydroxyapatite films at a diameter of 100 μm were formed by tuning the concentrations of calcium hydroxide and phosphoric acid aqueous solutions. This technique allows for the direct fabrication of the hydroxyapatite films without crystal growth process in hydroxyapatite precursors, the scaffolds of crystal growth such as biocompatibility SiO2-CaO glasses, or electrophoresis processes. By using this technique, large-area ceramic films with biocompatibility will be micropatterned with minimized material consumption, short fabrication time, and reduced equipment investments.

  11. Non-homologous isofunctional enzymes: a systematic analysis of alternative solutions in enzyme evolution.

    Science.gov (United States)

    Omelchenko, Marina V; Galperin, Michael Y; Wolf, Yuri I; Koonin, Eugene V

    2010-04-30

    Evolutionarily unrelated proteins that catalyze the same biochemical reactions are often referred to as analogous - as opposed to homologous - enzymes. The existence of numerous alternative, non-homologous enzyme isoforms presents an interesting evolutionary problem; it also complicates genome-based reconstruction of the metabolic pathways in a variety of organisms. In 1998, a systematic search for analogous enzymes resulted in the identification of 105 Enzyme Commission (EC) numbers that included two or more proteins without detectable sequence similarity to each other, including 34 EC nodes where proteins were known (or predicted) to have distinct structural folds, indicating independent evolutionary origins. In the past 12 years, many putative non-homologous isofunctional enzymes were identified in newly sequenced genomes. In addition, efforts in structural genomics resulted in a vastly improved structural coverage of proteomes, providing for definitive assessment of (non)homologous relationships between proteins. We report the results of a comprehensive search for non-homologous isofunctional enzymes (NISE) that yielded 185 EC nodes with two or more experimentally characterized - or predicted - structurally unrelated proteins. Of these NISE sets, only 74 were from the original 1998 list. Structural assignments of the NISE show over-representation of proteins with the TIM barrel fold and the nucleotide-binding Rossmann fold. From the functional perspective, the set of NISE is enriched in hydrolases, particularly carbohydrate hydrolases, and in enzymes involved in defense against oxidative stress. These results indicate that at least some of the non-homologous isofunctional enzymes were recruited relatively recently from enzyme families that are active against related substrates and are sufficiently flexible to accommodate changes in substrate specificity.

  12. Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

    Directory of Open Access Journals (Sweden)

    Wolf Yuri I

    2010-04-01

    Full Text Available Abstract Background Evolutionarily unrelated proteins that catalyze the same biochemical reactions are often referred to as analogous - as opposed to homologous - enzymes. The existence of numerous alternative, non-homologous enzyme isoforms presents an interesting evolutionary problem; it also complicates genome-based reconstruction of the metabolic pathways in a variety of organisms. In 1998, a systematic search for analogous enzymes resulted in the identification of 105 Enzyme Commission (EC numbers that included two or more proteins without detectable sequence similarity to each other, including 34 EC nodes where proteins were known (or predicted to have distinct structural folds, indicating independent evolutionary origins. In the past 12 years, many putative non-homologous isofunctional enzymes were identified in newly sequenced genomes. In addition, efforts in structural genomics resulted in a vastly improved structural coverage of proteomes, providing for definitive assessment of (nonhomologous relationships between proteins. Results We report the results of a comprehensive search for non-homologous isofunctional enzymes (NISE that yielded 185 EC nodes with two or more experimentally characterized - or predicted - structurally unrelated proteins. Of these NISE sets, only 74 were from the original 1998 list. Structural assignments of the NISE show over-representation of proteins with the TIM barrel fold and the nucleotide-binding Rossmann fold. From the functional perspective, the set of NISE is enriched in hydrolases, particularly carbohydrate hydrolases, and in enzymes involved in defense against oxidative stress. Conclusions These results indicate that at least some of the non-homologous isofunctional enzymes were recruited relatively recently from enzyme families that are active against related substrates and are sufficiently flexible to accommodate changes in substrate specificity. Reviewers This article was reviewed by Andrei

  13. Sports Specialization, Part II: Alternative Solutions to Early Sport Specialization in Youth Athletes.

    Science.gov (United States)

    Myer, Gregory D; Jayanthi, Neeru; DiFiori, John P; Faigenbaum, Avery D; Kiefer, Adam W; Logerstedt, David; Micheli, Lyle J

    2016-01-01

    Many coaches, parents, and children believe that the best way to develop elite athletes is for them to participate in only 1 sport from an early age and to play it year-round. However, emerging evidence to the contrary indicates that efforts to specialize in 1 sport may reduce opportunities for all children to participate in a diverse year-round sports season and can lead to lost development of lifetime sports skills. Early sports specialization may also reduce motor skill development and ongoing participation in games and sports as a lifestyle choice. The purpose of this review is to employ the current literature to provide evidence-based alternative strategies that may help to optimize opportunities for all aspiring young athletes to maximize their health, fitness, and sports performance. Nonsystematic review with critical appraisal of existing literature. Clinical review. Level 4. Based on the current evidence, parents and educators should help provide opportunities for free unstructured play to improve motor skill development and youth should be encouraged to participate in a variety of sports during their growing years to influence the development of diverse motor skills. For those children who do choose to specialize in a single sport, periods of intense training and specialized sport activities should be closely monitored for indicators of burnout, overuse injury, or potential decrements in performance due to overtraining. Last, the evidence indicates that all youth should be involved in periodized strength and conditioning (eg, integrative neuromuscular training) to help them prepare for the demands of competitive sport participation, and youth who specialize in a single sport should plan periods of isolated and focused integrative neuromuscular training to enhance diverse motor skill development and reduce injury risk factors. B. © 2015 The Author(s).

  14. Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

    Science.gov (United States)

    2010-01-01

    Background Evolutionarily unrelated proteins that catalyze the same biochemical reactions are often referred to as analogous - as opposed to homologous - enzymes. The existence of numerous alternative, non-homologous enzyme isoforms presents an interesting evolutionary problem; it also complicates genome-based reconstruction of the metabolic pathways in a variety of organisms. In 1998, a systematic search for analogous enzymes resulted in the identification of 105 Enzyme Commission (EC) numbers that included two or more proteins without detectable sequence similarity to each other, including 34 EC nodes where proteins were known (or predicted) to have distinct structural folds, indicating independent evolutionary origins. In the past 12 years, many putative non-homologous isofunctional enzymes were identified in newly sequenced genomes. In addition, efforts in structural genomics resulted in a vastly improved structural coverage of proteomes, providing for definitive assessment of (non)homologous relationships between proteins. Results We report the results of a comprehensive search for non-homologous isofunctional enzymes (NISE) that yielded 185 EC nodes with two or more experimentally characterized - or predicted - structurally unrelated proteins. Of these NISE sets, only 74 were from the original 1998 list. Structural assignments of the NISE show over-representation of proteins with the TIM barrel fold and the nucleotide-binding Rossmann fold. From the functional perspective, the set of NISE is enriched in hydrolases, particularly carbohydrate hydrolases, and in enzymes involved in defense against oxidative stress. Conclusions These results indicate that at least some of the non-homologous isofunctional enzymes were recruited relatively recently from enzyme families that are active against related substrates and are sufficiently flexible to accommodate changes in substrate specificity. Reviewers This article was reviewed by Andrei Osterman, Keith F. Tipton

  15. Simultaneous copper, cobalt and phenol removal from aqueous solutions by alternating biosorption and biodegradation.

    Science.gov (United States)

    Tsekova, K; Ganeva, S; Hristov, A; Todorova, D; Beschkov, V

    2011-01-01

    A strategy for removal of heavy metals and phenol from wastewaters is proposed. It involves consecutive cation biosorption by fungi, phenol biodegradation by the yeast association Candida sp. 2326 + Candida sp. 2327 and regeneration. Copper and cobalt removal from aqueous solutions containing 80-120 mg/L phenol by biosorption, using Rhizopus archizus cells immobilized onto poly (vinyl alcohol), was investigated by conducting a series of batch experiments. The removal efficiencies were 81% for Cu and 5% for Co. The residual concentrations of Cu (1.9 mg/L) and of Co (9.5 mg/L) did not change the biodegradation dynamics of phenol. A quantitative biodegradation of 120 mg/L phenol proceeded within 22 h. After biodegradation of phenol, the removal efficiencies achieved by biosorption after regeneration were 90% for Cu and 44% for Co. It was found that copper and cobalt form positively charged complexes with phenol. This complex formation hinders the retention of Cu and Co by the biosorbent and reduces the uptake of their cations.

  16. Basic Problems in Design and Inverse Engineering Solution for Outer Characteristic of Vehicle Suspension Shock Absorbers

    Institute of Scientific and Technical Information of China (English)

    俞德孚; 陈庆东; 李文君

    2003-01-01

    Based on the theory and the practical experiences of linearity design of feasible design area and inverse solution of non-linear outer characteristic of suspension shock absorber, in accordance with non-linearity outer characteristic formed by open-up damping coefficient, full-open damping coefficient and smoothness to safety ratio of suspension shock absorber, a method and a research conclusion of the feasible design and inverse solution for the basic problems of designing and inverse solution of non-linear outer characteristic of suspension damping components are provided.

  17. New era / new solutions: The role of alternative tariff structures in water supply projects.

    Science.gov (United States)

    Pinto, F Silva; Marques, R Cunha

    2017-09-13

    Water utilities face different challenges that may force them to seek prioritized objectives. When doing so, particular projects may have to be developed, being important to understand their impact on water tariffs, and thus, on customers. Such consequences may bear an increased relevance in cases stressed with, e.g., resource scarcity, poverty, and the need for infrastructure investments. The resulting cost and revenue variability demand a comprehensive study. If the first may require a stochastic modeling (in major cost components) in order to consider its inherent uncertainty, the second needs to be modeled following context-specific objectives set by the relevant stakeholders. The solutions achieved will likely promote distinct revenue sources, as well as diversified water tariff structures. A multi-objective optimization model (i.e., a Framework for Suitable Prices) is built to deal with those diversified requirements (e.g., stochastic energy costs, affordability, cost recovery, or administrative simplicity). The model is solved through achievement scalarizing functions with several weighting coefficients for a reference point, so as to provide a significant perception of possible revenue options (and their impact) to the decision makers. The proposed method is applied to a case study, Boa Vista Island in Cabo Verde, in which the background characteristics, namely water sources availability (e.g., the adoption of desalination technologies), economic development and other contextual factors were considered. The key role of tariff structure selection is displayed, instead of assuming it a priori, giving important insights regarding project feasibility. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Designing a Business Intelligence Solution for Analyzing Security Data

    OpenAIRE

    Somasekaram, Premathas

    2013-01-01

    Business Intelligence is a set of tools and applications that are widely deployed across major corporations today. An appropriate translation for “Business Intelligence” in Swedish is “beslutstöd”, and it clearly describes the purpose of such a solution, andt hat is to collect, compress, consolidate and analyze data from multiple sources, so that critical decisions can be made based on it hence the name “beslutstöd. The focusof Business Intelligence has been on business data, so that trends a...

  19. Colloidal properties of biomacromolecular solutions: Towards urate oxidase crystal design

    Science.gov (United States)

    Bonneté, Françoise

    2013-02-01

    Crystallization of biological macromolecules is governed by weak interaction forces, attractive and repulsive. Knowledge of solution properties, via second virial coefficient measurements, makes it possible to select physico-chemical parameters that govern and control phase diagrams and thus to grow crystals for specific applications (bio-crystallography or pharmaceutical processes). We highlight here with urate oxidase a salting-in effect that increases its solubility and the depletion effect of amphiphilic polymer, at a polymer concentration above its cmc, in order to grow diffracting crystals of urate oxidase. These two effects were used to grow crystals for high pressure crystallography and in a purification process.

  20. Technology Solutions Case Study: Hydronic Systems: Designing for Setback Operation

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-05-01

    For years, conventional wisdom surrounding space heating has specified two points: size the mechanical systems to the heating loads, and setting the thermostat back at night will result in energy savings. The problem is these two recommendations oppose each other. A system that is properly sized to the heating load will not have the extra capacity necessary to recover from a thermostat setback, especially at design conditions. Properly designing a hydronic system for setback operation can be accomplished but depends on several factors. Determining the appropriateness of setback for a particular project is the first step. This is followed by proper sizing of the boiler and baseboard to ensure the needed capacity can be met. Finally, control settings must be chosen that result in the most efficient and responsive performance. This guide provides step-by-step instructions for heating contractors and hydronic designers for selecting the proper control settings to maximize system performance and improve response time when using a thermostat setback.

  1. Technology Solutions Case Study: Hydronic Systems: Designing for Setback Operation

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-05-01

    For years, conventional wisdom surrounding space heating has specified two points: size the mechanical systems to the heating loads, and setting the thermostat back at night will result in energy savings. The problem is these two recommendations oppose each other. A system that is properly sized to the heating load will not have the extra capacity necessary to recover from a thermostat setback, especially at design conditions. Properly designing a hydronic system for setback operation can be accomplished but depends on several factors. Determining the appropriateness of setback for a particular project is the first step. This is followed by proper sizing of the boiler and baseboard to ensure the needed capacity can be met. Finally, control settings must be chosen that result in the most efficient and responsive performance. This guide provides step-by-step instructions for heating contractors and hydronic designers for selecting the proper control settings to maximize system performance and improve response time when using a thermostat setback.

  2. APPROXIMATE SOLUTION USING A PERTURBATION METHOD FOR DETENTION POND DESIGN

    Institute of Scientific and Technical Information of China (English)

    Jen-Yan CHEN; Yao-Ming HONG

    2002-01-01

    It is a common practice to use a hydrological continuity equation as the governing equation in detention pond design. Although the detention volume can be evaluated using a numerical method and computer program,they are not available for engineers to use because of the difficulty involved in the numerical evaluation or the computer program may not be ready for engineers. This study intends to provide a formula for calculating the volume of a detention pond. A nonlinear continuity equation for detention pond design is obtained by applying a triangular/trapezoidal inflow hydrograph and spillway or orifice for the outflow device. This perturbation method is employed to resolve the equation. After discussing the omission and curve fitting methods,a formula for detention pond design is proposed.Several examples are displayed and a high agreement with the numerical result is obtained.

  3. Alternative communication network designs for an operational Plato 4 CAI system

    Science.gov (United States)

    Mobley, R. E., Jr.; Eastwood, L. F., Jr.

    1975-01-01

    The cost of alternative communications networks for the dissemination of PLATO IV computer-aided instruction (CAI) was studied. Four communication techniques are compared: leased telephone lines, satellite communication, UHF TV, and low-power microwave radio. For each network design, costs per student contact hour are computed. These costs are derived as functions of student population density, a parameter which can be calculated from census data for one potential market for CAI, the public primary and secondary schools. Calculating costs in this way allows one to determine which of the four communications alternatives can serve this market least expensively for any given area in the U.S. The analysis indicates that radio distribution techniques are cost optimum over a wide range of conditions.

  4. Design of Optimal Sparse Feedback Gains via the Alternating Direction Method of Multipliers

    CERN Document Server

    Lin, Fu; Jovanović, Mihailo R

    2011-01-01

    We design sparse and block sparse feedback gains that minimize the $H_2$ norm of distributed systems. Our approach consists of two steps. First, we identify sparsity patterns of the feedback gains by incorporating sparsity-promoting penalty functions into the $H_2$ problem, where the added terms penalize the number of communication links in the distributed controller. Second, we optimize the state feedback gains subject to the structural constraints determined by the identified sparsity patterns. This polishing step improves the $H_2$ performance of the distributed controllers. In the first step, we identify sparsity structure of the feedback gains using the alternating direction method of multipliers, which is a powerful algorithm well-suited to large optimization problems. This method alternates between optimizing the sparsity and optimizing the closed-loop $H_2$ norm, which allows us to exploit the structure of the corresponding objective functions. In particular, we take advantage of the separability of t...

  5. Mechanical Design of an Alternate Structure for LARP Nb3Sn Quadrupole Magnets for LHC

    CERN Document Server

    Anerella, M; Kovach, P; Schmalzle, J; Wanderer, P; Ambrosio, G; Lamm, M J; Caspi, S; Felice, H; Ferracin, P; Sabbi, G L

    2011-01-01

    An alternative structure for the 120 mm Nb3Sn quadrupole magnet is presently under development for use in the upgrade for LHC at CERN. The design aims to build existing technology developed in LARP with the LQ and HQ magnets and to further optimize the features required for operation in the accelerator. The structure includes features for maintaining mechanical alignment of the coils to achieve the required field quality. It also includes a helium containment vessel and provisions for cooling with 1.9 K helium. The development effort includes the assembly of a six inch model to verify required coil load is achieved. Status of the R&D effort and an update on the magnet design, including its incorporation into the design of a complete one meter cold mass is presented.

  6. Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives.

    Science.gov (United States)

    Shearer, Robert F; Saunders, Darren N

    2015-01-01

    The use of third-generation lentiviral vectors is now commonplace in most areas of basic biology. These systems provide a fast, efficient means for modulating gene expression, but experimental design needs to be carefully considered to minimize potential artefacts arising from off-target effects and other confounding factors. This review offers a starting point for those new to lentiviral-based vector systems, addressing the main issues involved with the use of lentiviral systems in vitro and outlines considerations which should be taken into account during experimental design. Factors such as selecting an appropriate system and controls, and practical titration of viral transduction are important considerations for experimental design. We also briefly describe some of the more recent advances in genome editing technology. TALENs and CRISPRs offer an alternative to lentivirus, providing endogenous gene editing with reduced off-target effects often at the expense of efficiency.

  7. Design and First Measurements of an Alternative Calorimetry Chamber for the HZB Quadrupole Resonator

    CERN Document Server

    Keckert, Sebastian; Knobloch, Jens; Kugeler, Oliver

    2015-01-01

    The systematic research on superconducting thin films requires dedicated testing equipment. The Quadrupole Resonator (QPR) is a specialized tool to characterize the superconducting RF properties of circular planar samples. A calorimetric measurement of the RF surface losses allows the surface resistance to be measured with sub nano-ohm resolution. This measurement can be performed over a wide temperature and magnetic field range, at frequencies of 433, 866 and 1300 MHz. The system at Helmholtz-Zentrum Berlin (HZB) is based on a resonator built at CERN and has been optimized to lower peak electric fields and an improved resolution. In this paper the design of an alternative calorimetry chamber is presented, providing flat samples for coating which are easy changeable. All parts are connected by screwing connections and no electron beam welding is required. Furthermore this design enables exchangeability of samples between the resonators at HZB and CERN. First measurements with the new design show ambiguous r...

  8. Solar energised transport solution and customer preferences and opinions about alternative fuel Vehicles – the case of slovenia

    Directory of Open Access Journals (Sweden)

    Matjaž KNEZ

    2015-09-01

    Full Text Available Authorities in Slovenia and other EU member states are confronted with problems of city transportation. Fossil-fuel based transport poses two chief problems – local and global pollution, and dwindling supplies and ever increasing costs. An elegant solution is to gradually replace the present automobile fleet with low emission vehicles. This article first explores the economics and practical viability of the provision of solar electricity for the charging of electric vehicles by installation of economical available PV modules and secondly the customer preferences and opinions about alternative low emission vehicles. Present estimates indicate that for the prevailing solar climate of Celje – a medium-sized Slovenian town – the cost would be only 2.11€ cents/kWh of generated solar electricity. Other results have also revealed that the most relevant factor for purchasing low emission vehicle is total vehicle price.

  9. Design and Modeling Billing solution to Next Generation Networks

    CERN Document Server

    Lakhtaria, Kamaljit I

    2010-01-01

    Next generation networks (NGN) services are assumed to be a new revenue stream for both network operators and service providers. New services especially focused on a mobile telecommunications that would be used not only as a communication de vice but also as a personal gateway to order or consume a variety of services and products [1]. This type of advanced services can be accomplished when the adaptability of the packet-networks (Internet) and the quality of service of the circuit switched networks are combined into one network [2]. New challenges appear in the billing of this heterogeneous multi services network. Some examples of such a services and possible solutions about charging and billing are examined in this paper. The first steps of mathematical model for billing are also considered.

  10. Development of a Design Support System that Can Efficiently Utilize Non-dominated Solutions

    Science.gov (United States)

    Watanabe, Shinya; Minato, Ryojiro

    This paper proposes a new design support approach, which efficiently utilizes the information of many non-dominated solutions obtained from evolutionary multi-criterion optimization (EMO). The proposed approach consists of four mechanisms: grouping (clustering), reducing the number of candidates (selecting the representative solutions), dimensionality reduction, and estimation. Non-dominated solutions can be regarded as a beneficial subspace in whole search space, which have the feature of being non-inferior to other solutions. Therefore, we think the proposed approach can be used to estimate the characteristics of a problem through the interaction with the designer. In this paper, we examine the characteristics and effectiveness of the proposed approach through computational experiments on a design problem of a counter rotating axial fan turbojet engine. A counter rotating axial fan turbojet engine with two spools is chosen for the design target of the present study. We handle this task as a seven-objective design problem.

  11. Analysis of solution findings in the conceptual design of function structures

    Institute of Scientific and Technical Information of China (English)

    SHI Dong-yan; QIU Chang-hua; XUE Jun-fang; HUANG Mei

    2005-01-01

    In the conceptual stage the function design process is realized by the computer aided application. After surveying on the function specification methods and the function modeling, a computer aided function design environment is analyzed. Subsequently based on a module library and principle catalogue, a solution finding process as a part of conceptual design is proposed for a creative design. In addition, a search algorithm to find the solution of adaptable function structure is also discussed. The concepts proposed in this paper can support the subsequent design stages, especially simulation for checking the function structure defects.

  12. Designing Intuitive Web Solutions for Monitoring Patients’ Rehabilitation at Home

    Directory of Open Access Journals (Sweden)

    Raihana Ferdous

    2015-12-01

    Full Text Available This paper describes the design of web-based remote monitoring interfaces aimed at supporting therapists and caregivers in supervising motor-cognitive rehabilitation plans of care to be performed by patients at home. This work was part of a three years’ research project where game-based environments for upper body motor rehabilitation of post-stroke patients were developed in collaboration with two main rehabilitation centers in Italy and Austria, for a subsequent deployment at patients’ homes. The paper will specifically focus on describing the iterative design of the home rehabilitation features for clinicians over the first two years of the project to enable the delivery and monitoring of more personalized, engaging plans of care for home therapy by rehabilitation centers and services.

  13. SustainPro - A tool for systematic process analysis, generation and evaluation of sustainable design alternatives

    DEFF Research Database (Denmark)

    Carvalho, Ana; Matos, Henrique A.; Gani, Rafiqul

    2013-01-01

    Chemical processes are continuously facing challenges from the demands of the global market related to economics, environment and social issues. This paper presents the development of a software tool (SustainPro) and its application to chemical processes operating in batch or continuous modes...... the user through the necessary steps according to work-flow of the implemented methodology. At the end the design alternatives, are evaluated using environmental impact assessment tools and safety indices. The extended features of the methodology incorporate Life Cycle Assessment analysis and economic...

  14. Interdigital H -mode drift-tube linac design with alternative phase focusing for muon linac

    Science.gov (United States)

    Otani, M.; Mibe, T.; Yoshida, M.; Hasegawa, K.; Kondo, Y.; Hayashizaki, N.; Iwashita, Y.; Iwata, Y.; Kitamura, R.; Saito, N.

    2016-04-01

    We have developed an interdigital H-mode (IH) drift-tube linac (DTL) design with an alternative phase focusing (APF) scheme for a muon linac, in order to measure the anomalous magnetic moment and electric dipole moment (EDM) of muons at the Japan Proton Accelerator Research Complex (J-PARC). The IH-DTL accelerates muons from β =v /c =0.08 to 0.28 at an operational frequency of 324 MHz. The output beam emittances are calculated as 0.315 π and 0.195 π mm mrad in the horizontal and vertical directions, respectively, which satisfies the experimental requirement.

  15. Feed-water heaters alternative design comparison; Comparacion de disenos alternativos de calentadores

    Energy Technology Data Exchange (ETDEWEB)

    Torres Toledano, Gerardo [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1988-12-31

    A procedure is presented for the alternative design comparison of feed water heaters, based in the failure records of damaged tubes during operation. The procedure is used for cases in which non-continuous or random inspections are made to the feed-water heaters. [Espanol] Se presenta un procedimiento para comparar disenos alternativos de calentadores, basandose en los registros de fallas de los tubos rotos acumuladas durante su operacion. El procedimiento se emplea para casos en los que se realizan inspecciones a los calentadores no continuas, ya sea periodicas o al azar.

  16. Fly ash: An alternative to powdered activated carbon for the removal of eosin dye from aqueous solutions

    Directory of Open Access Journals (Sweden)

    V.O. Njoku

    2013-05-01

    Full Text Available This paper reports the use of powdered activated carbon (PAC and raw coal fly ash (RFA in the removal of eosin dye from aqueous solution in batch processes. Operational parameters such as contact time, initial dye concentration, pH and temperature were investigated. Adsorption equilibrium was established in 120 min for the two adsorbents. Langmuir and Freundlich isotherms were used to fit the adsorption data. Langmuir model gave the best fit in both cases. The adsorption capacities of PAC and RFA were found to be 62.28 mg/g and 43.48 mg/g, respectively. The highest percentage of eosin dye removal for both PAC (98% and RFA (90% was observed at pH 2. Pseudo first-order and pseudo second-order kinetic models were used to fit the adsorption data. Pseudo second-order kinetic model gave the best description of the adsorption of eosin dye onto the two adsorbents. Thermodynamic parameters, ΔH0, ΔS0 and ΔG0 confirmed the physical nature, spontaneity and the endothermic nature of the adsorption process. A regeneration technique and a process calculation for evaluating the adsorbent dose required were carried out. This study has shown that RFA is a good alternative adsorbent in the removal of eosin dye from aqueous solution.

  17. Design of air-gapped magnetic-core inductors for superimposed direct and alternating currents

    Science.gov (United States)

    Ohri, A. K.; Wilson, T. G.; Owen, H. A., Jr.

    1976-01-01

    Using data on standard magnetic-material properties and standard core sizes for air-gap-type cores, an algorithm designed for a computer solution is developed which optimally determines the air-gap length and locates the quiescent point on the normal magnetization curve so as to yield an inductor design with the minimum number of turns for a given ac voltage and frequency and with a given dc bias current superimposed in the same winding. Magnetic-material data used in the design are the normal magnetization curve and a family of incremental permeability curves. A second procedure, which requires a simpler set of calculations, starts from an assigned quiescent point on the normal magnetization curve and first screens candidate core sizes for suitability, then determines the required turns and air-gap length.

  18. A framework to support decision making in the selection of sustainable drainage system design alternatives.

    Science.gov (United States)

    Wang, Mingming; Sweetapple, Chris; Fu, Guangtao; Farmani, Raziyeh; Butler, David

    2017-10-01

    This paper presents a new framework for decision making in sustainable drainage system (SuDS) scheme design. It integrates resilience, hydraulic performance, pollution control, rainwater usage, energy analysis, greenhouse gas (GHG) emissions and costs, and has 12 indicators. The multi-criteria analysis methods of entropy weight and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) were selected to support SuDS scheme selection. The effectiveness of the framework is demonstrated with a SuDS case in China. Indicators used include flood volume, flood duration, a hydraulic performance indicator, cost and resilience. Resilience is an important design consideration, and it supports scheme selection in the case study. The proposed framework will help a decision maker to choose an appropriate design scheme for implementation without subjectivity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Preliminary design study of an alternate heat source assembly for a Brayton isotope power system

    Science.gov (United States)

    Strumpf, H. J.

    1978-01-01

    Results are presented for a study of the preliminary design of an alternate heat source assembly (HSA) intended for use in the Brayton isotope power system (BIPS). The BIPS converts thermal energy emitted by a radioactive heat source into electrical energy by means of a closed Brayton cycle. A heat source heat exchanger configuration was selected and optimized. The design consists of a 10 turn helically wound Hastelloy X tube. Thermal analyses were performed for various operating conditions to ensure that post impact containment shell (PICS) temperatures remain within specified limits. These limits are essentially satisfied for all modes of operation except for the emergency cooling system for which the PICS temperatures are too high. Neon was found to be the best choice for a fill gas for auxiliary cooling system operation. Low cycle fatigue life, natural frequency, and dynamic loading requirements can be met with minor modifications to the existing HSA.

  20. The Effectiveness of Hybrid Solutions in Higher Education: A Call for Hybrid-Teaching Instructional Design

    Science.gov (United States)

    Trentin, Guglielmo; Bocconi, Stefania

    2014-01-01

    In order to design learning solutions that effectively embed face-to-face and online dimensions, it is crucial to identify the key components underpinning hybrid solutions. Furthermore, once these components have been identified, there is the need to clarify how to recombine them to meet a specific learning objective. This article aims to…

  1. Envelope periodic solutions for a discrete network with the Jacobi elliptic functions and the alternative (G'/G)-expansion method including the generalized Riccati equation

    Science.gov (United States)

    Tala-Tebue, E.; Tsobgni-Fozap, D. C.; Kenfack-Jiotsa, A.; Kofane, T. C.

    2014-06-01

    Using the Jacobi elliptic functions and the alternative ( G'/ G-expansion method including the generalized Riccati equation, we derive exact soliton solutions for a discrete nonlinear electrical transmission line in (2+1) dimension. More precisely, these methods are general as they lead us to diverse solutions that have not been previously obtained for the nonlinear electrical transmission lines. This study seeks to show that it is not often necessary to transform the equation of the network into a well-known differential equation before finding its solutions. The solutions obtained by the current methods are generalized periodic solutions of nonlinear equations. The shape of solutions can be well controlled by adjusting the parameters of the network. These exact solutions may have significant applications in telecommunication systems where solitons are used to codify or for the transmission of data.

  2. Sıkışma: An Alternative Information Design Project for Ihlamur Pavilions Istanbul.

    Science.gov (United States)

    Özmen, Melike

    2016-01-01

    Sıkışma is a transmedia information design project, which focuses on Ihlamur Pavilions and Ihlamur area. Ihlamur hosts Ihlamur Pavilions since 19th Century. It is located within Beşiktaş district in Istanbul. Nowadays the buildings belong to TBMM (The Grand National Assembly of Turkey) National Palaces and used as a Museum- Café. There is a conventional wayfinding & signage system for outdoor areas of the Pavilions. The system also includes two separate boards focusing on the history of Ihlamur and Ihlamur Pavilions. However, the information provided on these boards seems inadequate and the boards are physically damaged. According Universal Design approach it is possible to achieve good and functional design and solve the inadequacy problem by physically fixing information boards and re-setting the environment around the information boards according to Universal Design principles. Although, these principles provide solutions for important issues such as mobility, stability and accessibility, it doesn't provide sufficient proof of user engagement in terms of the creation of the content. The project Sıkışma offers an approach, which is concerned with content as with form and suggests that it is possible to infer a universal form from the content created through personal experience of the designer as a user. It is also intended to represent the past and the present through the project and to create an understanding of plausible scenarios of the unknown future in the viewers' mind.

  3. Lithography alternatives meet design style reality: How do they "line" up?

    Science.gov (United States)

    Smayling, Michael C.

    2016-03-01

    Optical lithography resolution scaling has stalled, giving innovative alternatives a window of opportunity. One important factor that impacts these lithographic approaches is the transition in design style from 2D to 1D for advanced CMOS logic. Just as the transition from 3D circuits to 2D fabrication 50 years ago created an opportunity for a new breed of electronics companies, the transition today presents exciting and challenging time for lithographers. Today, we are looking at a range of non-optical lithography processes. Those considered here can be broadly categorized: self-aligned lithography, self-assembled lithography, deposition lithography, nano-imprint lithography, pixelated e-beam lithography, shot-based e-beam lithography .Do any of these alternatives benefit from or take advantage of 1D layout? Yes, for example SAPD + CL (Self Aligned Pitch Division combined with Complementary Lithography). This is a widely adopted process for CMOS nodes at 22nm and below. Can there be additional design / process co-optimization? In spite of the simple-looking nature of 1D layout, the placement of "cut" in the lines and "holes" for interlayer connections can be tuned for a given process capability. Examples of such optimization have been presented at this conference, typically showing a reduction of at least one in the number of cut or hole patterns needed.[1,2] Can any of the alternatives complement each other or optical lithography? Yes.[3] For example, DSA (Directed Self Assembly) combines optical lithography with self-assembly. CEBL (Complementary e-Beam Lithography) combines optical lithography with SAPD for lines with shot-based e-beam lithography for cuts and holes. Does one (shrinking) size fit all? No, that's why we have many alternatives. For example NIL (Nano-imprint Lithography) has been introduced for NAND Flash patterning where the (trending lower) defectivity is acceptable for the product. Deposition lithography has been introduced in 3D NAND Flash to

  4. Randomized controlled trials and neuro-oncology: should alternative designs be considered?

    Science.gov (United States)

    Mansouri, Alireza; Shin, Samuel; Cooper, Benjamin; Srivastava, Archita; Bhandari, Mohit; Kondziolka, Douglas

    2015-09-01

    quality of design/reporting of RCTs in neuro-oncology persist. Quality improvement is necessary. Consideration of alternative strategies should be considered.

  5. RIP Input From WAPDEG for LA Desgin Selection: Enhanced Design Alternative II

    Energy Technology Data Exchange (ETDEWEB)

    B.E. Bullard

    1999-07-16

    The purpose of this analysis is to identify and analyze concepts for the acquisition of data in support of the Performance Confirmation (PC) program at the potential subsurface nuclear waste repository at Yucca Mountain. This analysis is being prepared to document an investigation of design concepts, current available technology, technology trends, and technical issues associated with data acquisition during the PC period. This analysis utilizes the ''Performance Confirmation Plan'' (CRWMS M&O 2000b) to help define the scope for the PC data acquisition system. The focus of this analysis is primarily on the PC period for a minimum of 30 years after emplacement of the last waste package. The design of the data acquisition system shall allow for a closure deferral up to 300 years from initiation of waste emplacement. (CRWMS M&O 2000h, page 5-1). This analysis is a revision to and supercedes analysis, ''Performance Confirmation Data Acquisition System'', DI No. BCAI00000-017 17-0200-00002 Rev 00 (CRWMS M&O 1997), and incorporates the latest repository design changes following the M&O & DOE evaluation of a series of Enhanced Design Alternatives (EDAs), as described in the ''Enhanced Design Alternatives II Report'' (CRWMS M&O 1999d). Significant design changes include: thermal line loading of the emplacement drifts, closer spacing of the waste packages (WPs), wider spacing and fewer emplacement drifts, continuous ventilation of all active emplacement drifts, thinner walled WP designs which will increase external radiation levels, a 50-year repository closure option, inclusion of a drip-shield, exclusion of backfill, and new conceptual designs for the waste emplacement vehicles and equipment (Stroupe 2000). The scope and primary objectives of this analysis are to: (1) Review the criteria for design as presented in the Performance Confirmation Data Acquisition/Monitoring System Description Document, by way of the

  6. Preliminary Evaluation of Alternate Designs for HFIR Low-Enriched Uranium Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Renfro, David G [ORNL; Chandler, David [ORNL; Cook, David Howard [ORNL; Ilas, Germina [ORNL; Jain, Prashant K [ORNL; Valentine, Jennifer R [ORNL

    2014-11-01

    Engineering design studies of the feasibility of conversion of the High Flux Isotope Reactor (HFIR) from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel are ongoing at Oak Ridge National Laboratory (ORNL) as part of an effort sponsored by the U.S. Department of Energy s Global Threat Reduction Initiative (GTRI)/Reduced Enrichment for Research and Test Reactors (RERTR) program. The fuel type selected by the program for the conversion of the five high-power research reactors in the U.S. that still use HEU fuel is a new U-Mo monolithic fuel. Studies by ORNL have previously indicated that HFIR can be successfully converted using the new fuel provided (1) the reactor power can be increased from 85 MW to 100 MW and (2) the fuel can be fabricated to a specific reference design. Fabrication techniques for the new fuel are under development by the program but are still immature, especially for the complex aspects of the HFIR fuel design. In FY 2012, the program underwent a major shift in focus to emphasize developing and qualifying processes for the fabrication of reliable and affordable LEU fuel. In support of this new focus and in an effort to ensure that the HFIR fuel design is as suitable for reliable fabrication as possible, ORNL undertook the present study to propose and evaluate several alternative design features. These features include (1) eliminating the fuel zone axial contouring in the previous reference design by substituting a permanent neutron absorber in the lower unfueled region of all of the fuel plates, (2) relocating the burnable neutron absorber from the fuel plates of the inner fuel element to the side plates of the inner fuel element (the fuel plates of the outer fuel element do not contain a burnable absorber), (3) relocating the fuel zone inside the fuel plate to be centered on the centerline of the depth of the plate, and (4) reshaping the radial contour of the relocated fuel zone to be symmetric about this centerline. The present

  7. Preliminary Evaluation of Alternate Designs for HFIR Low-Enriched Uranium Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Renfro, David [ORNL; Chandler, David [ORNL; Cook, David [ORNL; Ilas, Germina [ORNL; Jain, Prashant [ORNL; Valentine, Jennifer [ORNL

    2014-10-30

    Engineering design studies of the feasibility of conversion of the High Flux Isotope Reactor (HFIR) from high-enriched uranium (HEU) to low-enriched uranium (LEU) fuel are ongoing at Oak Ridge National Laboratory (ORNL) as part of an effort sponsored by the U.S. Department of Energy’s Global Threat Reduction Initiative (GTRI)/Reduced Enrichment for Research and Test Reactors (RERTR) program. The fuel type selected by the program for the conversion of the five high-power research reactors in the U.S. that still use HEU fuel is a new U-Mo monolithic fuel. Studies by ORNL have previously indicated that HFIR can be successfully converted using the new fuel provided (1) the reactor power can be increased from 85 MW to 100 MW and (2) the fuel can be fabricated to a specific reference design. Fabrication techniques for the new fuel are under development by the program but are still immature, especially for the “complex” aspects of the HFIR fuel design. In FY 2012, the program underwent a major shift in focus to emphasize developing and qualifying processes for the fabrication of reliable and affordable LEU fuel. In support of this new focus and in an effort to ensure that the HFIR fuel design is as suitable for reliable fabrication as possible, ORNL undertook the present study to propose and evaluate several alternative design features. These features include (1) eliminating the fuel zone axial contouring in the previous reference design by substituting a permanent neutron absorber in the lower unfueled region of all of the fuel plates, (2) relocating the burnable neutron absorber from the fuel plates of the inner fuel element to the side plates of the inner fuel element (the fuel plates of the outer fuel element do not contain a burnable absorber), (3) relocating the fuel zone inside the fuel plate to be centered on the centerline of the depth of the plate, and (4) reshaping the radial contour of the relocated fuel zone to be symmetric about this centerline. The

  8. Testing Spirotetramat as an Alternative Solution to Abamectin for Cacopsylla pyri (Hemiptera: Psyllidae) Control: Laboratory and Field Tests.

    Science.gov (United States)

    Civolani, Stefano; Boselli, Mauro; Butturini, Alda; Chicca, Milvia; Cassanelli, Stefano; Tommasini, Maria Grazia; Aschonitis, Vassilis; Fano, Elisa Anna

    2015-12-01

    Aim of the study was to investigate the performance of the new insecticide "spirotetramat" as an alternative solution of "abamectin" for the control of Cacopsylla pyri L. (Hemiptera: Psyllidae) in the context of an IPM program in European pear, Pyrus communis L.. Laboratory bioassays for the estimation of LC50 and LC90 of both insecticides were performed using four populations collected in Emilia-Romagna (Italy) orchards where different pest management strategies were used (organic, integrated, and conventional). The same populations were also analyzed for the main insecticide detoxifying activities in nymphs by spectrofluorimetric in vitro assays. The performance of the two insecticides was also tested on field on one population under integrated pest management conditions. The laboratory experiments showed that the LC90 of spirotetramat were lower than the highest field concentration allowed in Europe (172.80 mg AI liter(-1)) giving reassurance about the efficacy of the product. Concerning the abamectin, the laboratory bioassays did not show strong indications of resistance development of C. pyri populations of Emilia-Romagna. A similarity in enzyme detoxifying activity was observed in both insecticides indicating a general absence of a significant insecticide resistance. The field trial showed a high efficacy (>90 %) of spirotetramat on C. pyri already after 15 d from application, and it was significantly higher from abamectin. Overall, spirotetramat is one more choice for C. pyri control, as well as abamectin in order to minimize the risks of occurrence of insecticide resistance.

  9. Alternate Immersion in an External Glucose Solution Differentially Affects Blood Sugar Values in Older Versus Younger Zebrafish Adults.

    Science.gov (United States)

    Connaughton, Victoria P; Baker, Cassandra; Fonde, Lauren; Gerardi, Emily; Slack, Carly

    2016-04-01

    Recently, zebrafish have been used to examine hyperglycemia-induced complications (retinopathy and neuropathy), as would occur in individuals with diabetes. Current models to induce hyperglycemia in zebrafish include glucose immersion and streptozotocin injections. Both are effective, although neither is reported to elevate blood sugar values for more than 1 month. In this article, we report differences in hyperglycemia induction and maintenance in young (4-11 months) versus old (1-3 years) zebrafish adults. In particular, older fish immersed in an alternating constant external glucose solution (2%) for 2 months displayed elevated blood glucose levels for the entire experimental duration. In contrast, younger adults displayed only transient hyperglycemia, suggesting the fish were acclimating to the glucose exposure protocol. However, modifying the immersion protocol to include a stepwise increasing glucose concentration (from 1% → 2%→3%) resulted in maintained hyperglycemia in younger zebrafish adults for up to 2 months. Glucose-exposed younger fish collected after 8 weeks of exposure also displayed a significant decrease in wet weight. Taken together, these data suggest different susceptibilities to hyperglycemia in older and younger fish and that stepwise increasing glucose concentrations of 1% are required for maintenance of hyperglycemia in younger adults, with higher concentrations of glucose resulting in greater increases in blood sugar values.

  10. Hank's balanced salt solution: an alternative resuspension medium to label autologous leukocytes. Experience in inflammatory bowel disease

    Energy Technology Data Exchange (ETDEWEB)

    Martin-Comin, Joseph; Plaza, Pedro; Roca, Manoel [Hospital de Bellvitge (Spain). Servico de Medicina Nuclear]. E-mail: jmartincomin@csub.scs.es; Cardoso, Valbert Nascimento [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Faculdade de Farmacia

    2002-09-01

    In this work Hank balanced salt solution (HBSS) has been used as resuspension medium, instead of leukocyte poor plasma (LPP) to label autologous white blood cells in 28 patients with suspicion of active inflammatory bowel disease. Labelled cells were reinjected and anterior and caudo-cranial views were obtained at 30 min, 2 h and 6 h p.i. Regions of interest were outlined on liver, spleen, lung, bone marrow (spine), background and lesions and the organ/background activity ratios were calculated in all scans. Patients were classified into 2 groups: Group 1: LPP, 30 patients and Groups 2: HBSS, 28 patients. labelling efficiency was higher in HBSS group (89.0 +- 3.2%) than in the LPP group (6.5 +- 6.3%). Organ/background activity ratios were similar in both groups. Concerning diagnostic accuracy was similar at 30 min and 2 h but the false positive rate increased at 6 h p.i. in the HBSS group. HBSS seems to be a valid alternative as resuspension medium in the labeling of autologous leukocytes but leukocyte poor plasma seem to induce less leukocyte damage. Based on these results, in our center HBSS is the currently used medium to label leukocytes. (author)

  11. Hank?s balanced salt solution: an alternative resuspension medium to label autologous leukocytes. Experience in inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Martin-Comin Joseph

    2002-01-01

    Full Text Available In this work Hank's balanced salt solution (HBSS has been used, as resuspension medium, instead of leukocyte poor plasma (LPP to label autologous white blood cells in 28 patients with suspicion af active inflammatory bowel disease.Labelled cells were reinjected and anterior and caudo-craneal views were obtained at 30 min, 2 h and 6 h p.i. Regions of interest were outlined on liver, spleen, lung, bone marrow (spine, background and lesions and the organ/background activity ratios were calculated in all scans. Patients were classified into 2 groups: Group 1: LPP, 30 patients and Groups 2: HBSS, 28 patients. Labelling efficiency was higher in HBBS group (89.0 ± 3.2 % than in the LPP group (6.5 ± 6.3%. Organ/background activity ratios were similar in both groups. Concerning diagnostic accuracy was similar at 30 min and 2 h but the false positive rate increased at 6 h p.i. in the HBSS group. HBSS seems to be a valid alternative as resuspension medium in the labeling of autologous leukocytes but leukocyte poor plasma seem to induce less leukocyte damage. Based on these results, in our center HBSS is the currently used medium to label leukocytes.

  12. Multilevel modeling was a convenient alternative to common regression designs in longitudinal suicide research.

    Science.gov (United States)

    Antretter, Elfi; Dunkel, Dirk; Osvath, Peter; Voros, Viktor; Fekete, Sandor; Haring, Christian

    2006-06-01

    The prospective investigation of repetitive nonfatal suicidal behavior is associated with two methodological problems. Due to the commonly used definitions of nonfatal suicidal behavior, clinical samples usually consist of patients with a considerable between-person variability. Second, repeated nonfatal suicidal episodes of the same subjects are likely to be correlated. We examined three regression techniques to comparatively evaluate their efficiency in addressing the given methodological problems. Repeated episodes of nonfatal suicidal behavior were assessed in two independent patient samples during a 2-year follow-up period. The first regression design modeled repetitive nonfatal suicidal behavior as a summary measure. The second regression model treated repeated episodes of the same subject as independent events. The third regression model represented a hierarchical linear model. The estimated mean effects of the first model were likely to be nonrepresentative for a considerable part of the study subjects. The second regression design overemphasized the impact of the predictor variables. The hierarchical linear model most appropriately accounted for the heterogeneity of the samples and the correlated data structure. The nonhierarchical regression designs did not provide appropriate statistical models for the prospective investigation of repetitive nonfatal suicidal behavior. Multilevel modeling provides a convenient alternative.

  13. User-Centered Design and Augmentative and Alternative Communication Apps for Children With Autism Spectrum Disorders

    Directory of Open Access Journals (Sweden)

    Margaret Lubas

    2014-05-01

    Full Text Available Communication difficulties are among the most frequent characteristics of children with autism spectrum disorders (ASD. Lack of communication can have a significant impact on the child’s life. Augmentative and alternative communication (AAC apps are a common form of AAC interventions that involve a combination of affordable technology with software that can be utilized to assist with communication. While AAC apps have been found to have some impact on improving the communication skills of children with ASD, current research exploring this topic is still limited. Focusing on the design process of AAC apps may provide better insight into improving clinical outcomes and user success. The user-centered design process incorporates a continuous cycle of user feedback to help inform and improve the functions and the capabilities of the technology, and it is an essential component in AAC app development. This article outlines how the user-centered design process could be adopted for the development of AAC apps for children with ASD.

  14. Alternative method for design and optimization of the ring resonator used in micro-optic gyro.

    Science.gov (United States)

    Wang, Kunbo; Feng, Lishuang; Wang, Junjie; Lei, Ming

    2013-03-01

    The ring resonator is one of the key elements in the micro-optic gyro system, but there is not a uniform method for designing the parameters of a ring resonator, especially for its size. In this paper, an alternative method is presented for designing the ring resonator used in micro-optic gyro. Maximization of the resonator output is proposed to be the principle in design and optimization for the first time to our knowledge. The scale factor accuracy and the full range of the gyro system are taken into account to obtain the optimum diameter of the ring. A theoretical optimal diameter of 0.25 m is achieved for SiO(2) waveguide resonator with a dynamic range of ±500°/s by analyzing the influence of resonator parameters on the output in detail, and the corresponding sensitivity of the gyro is less than 1.28°/h, which can meet the demands of a tactical inertia system.

  15. Exploring How Experience with Planning Impacts First Grade Students' Planning and Solutions to Engineering Design Problems

    Science.gov (United States)

    Portsmore, Merredith D.

    2010-01-01

    This dissertation presents research that investigated how first grade students' ability to construct solutions and to plan through drawing for engineering design problems is related to their participation in a LEGO-based engineering curriculum with two variations on the instruction for planning. The quasi-experimental design engaged two first…

  16. Designing Alternative Transport Methods for the Distributed Data Collection of ATLAS EventIndex Project

    CERN Document Server

    Fernandez Casani, Alvaro; The ATLAS collaboration

    2016-01-01

    One of the key and challenging tasks of the ATLAS EventIndex project is to index and catalog all the produced events not only at CERN but also at hundreds of worldwide grid sites, and convey the data in real time to a central Hadoop instance at CERN. While this distributed data collection is currently operating correctly in production, there are some issues that might impose performance bottlenecks in the future, with an expected rise in the event production and reprocessing rates. In this work, we first describe the current approach based on a messaging system, which conveys the data from the sources to the central catalog, and we identify some weaknesses of this system. Then, we study a promising alternative transport method based on an object store, presenting a performance comparison with the current approach, and the architectural design changes needed to adapt the system to the next run of the ATLAS experiment at CERN.

  17. Composting on Mars or the Moon: I. Comparative evaluation of process design alternatives

    Science.gov (United States)

    Finstein, M. S.; Strom, P. F.; Hogan, J. A.; Cowan, R. M.; Janes, H. W. (Principal Investigator)

    1999-01-01

    As a candidate technology for treating solid wastes and recovering resources in bioregenerative Advanced Life Support, composting potentially offers such advantages as compactness, low mass, near ambient reactor temperatures and pressures, reliability, flexibility, simplicity, and forgiveness of operational error or neglect. Importantly, the interactions among the physical, chemical, and biological factors that govern composting system behavior are well understood. This article comparatively evaluates five Generic Systems that describe the basic alternatives to composting facility design and control. These are: 1) passive aeration; 2) passive aeration abetted by mechanical agitation; 3) forced aeration--O2 feedback control; 4) forced aeration--temperature feedback control; 5) forced aeration--integrated O2 and temperature feedback control. Each of the five has a distinctive pattern of behavior and process performance characteristics. Only Systems 4 and 5 are judged to be viable candidates for ALS on alien worlds, though which is better suited in this application is yet to be determined.

  18. A Synthesis of Relevant Literature on the Development of Emotional Competence: Implications for Design of Augmentative and Alternative Communication Systems.

    Science.gov (United States)

    Na, Ji Young; Wilkinson, Krista; Karny, Meredith; Blackstone, Sarah; Stifter, Cynthia

    2016-08-01

    Emotional competence refers to the ability to identify, respond to, and manage one's own and others' emotions. Emotional competence is critical to many functional outcomes, including making and maintaining friends, academic success, and community integration. There appears to be a link between the development of language and the development of emotional competence in children who use speech. Little information is available about these issues in children who rely on augmentative and alternative communication (AAC). In this article, we consider how AAC systems can be designed to support communication about emotions and the development of emotional competence. Because limited research exists on communication about emotions in a context of aided AAC, theory and research from other fields (e.g., psychology, linguistics, child development) is reviewed to identify key features of emotional competence and their possible implications for AAC design and intervention. The reviewed literature indicated that the research and clinical attention to emotional competence in children with disabilities is encouraging. However, the ideas have not been considered specifically in the context of aided AAC. On the basis of the reviewed literature, we offer practical suggestions for system design and AAC use for communication about emotions with children who have significant disabilities. Three key elements of discussing emotions (i.e., emotion name, reason, and solution) are suggested for inclusion in order to provide these children with opportunities for a full range of discussion about emotions. We argue that supporting communication about emotions is as important for children who use AAC as it is for children who are learning speech. This article offers a means to integrate information from other fields for the purpose of enriching AAC supports.

  19. An alternative experimental case-control design for genetic association studies on bovine mastitis.

    Science.gov (United States)

    Biffani, S; Del Corvo, M; Capoferri, R; Pedretti, A; Luini, M; Williams, J L; Pagnacco, G; Minvielle, F; Minozzi, G

    2017-04-01

    The possibility of using genetic control strategies to increase disease resistance to infectious diseases relies on the identification of markers to include in the breeding plans. Possible incomplete exposure of mastitis-free (control) animals, however, is a major issue to find relevant markers in genetic association studies for infectious diseases. Usually, designs based on elite dairy sires are used in association studies, but an epidemiological case-control strategy, based on cows repeatedly field-tested could be an alternative for disease traits. To test this hypothesis, genetic association results obtained in the present work from a cohort of Italian Holstein cows tested for mastitis over time were compared with those from a previous genome-wide scan on Italian Holstein sires genotyped with 50k single nucleotide polymorphisms for de-regressed estimated breeding values for somatic cell counts (SCCs) on Bos taurus autosome (BTA6) and BTA14. A total of 1121 cows were selected for the case-control approach (cases=550, controls=571), on a combination of herd level of SCC incidence and of within herd individual level of SCC. The association study was conducted on nine previously identified markers, six on BTA6 and four on BTA14, using the R statistical environment with the 'qtscore' function of the GenABEL package, on high/low adjusted linear score as a binomial trait. The results obtained in the cow cohort selected on epidemiological information were in agreement with those obtained from the previous sire genome-wide association study (GWAS). Six out of the nine markers showed significant association, four on BTA14 (rs109146371, rs109234250, rs109421300, rs109162116) and two on BTA6 (rs110527224 and rs42766480). Most importantly, using mastitis as a case study, the current work further validated the alternative use of historical field disease data in case-control designs for genetic analysis of infectious diseases in livestock.

  20. Analytical solution and optimal design for galloping-based piezoelectric energy harvesters

    Science.gov (United States)

    Tan, T.; Yan, Z.

    2016-12-01

    The performance of the galloping-based piezoelectric energy harvester is usually investigated numerically. Instead of performing case studies by numerical simulations, analytical solutions of the nonlinear distributed parameter model are derived to capture the intrinsic effects of the physical parameters on the performance of such energy harvesters. The analytical solutions are confirmed with the numerical solutions. Optimal performance of such energy harvesters is therefore revealed theoretically. The electric damping due to the electromechanical coupling is defined. The design at the optimal electrical damping with smaller onset speed to galloping, higher harvested power, and acceptable tip displacement is superior than the design at the maximal electrical damping, as long as the optimal electrical damping can be achieved. Otherwise, the design at the maximal electrical damping should be then adopted. As the wind speed and aerodynamic empirical coefficients increase, the tip displacement and harvested power increase. This study provides a theoretical design and optimization procedure for galloping-based piezoelectric energy harvesters.

  1. Solution-verified reliability analysis and design of bistable MEMS using error estimation and adaptivity.

    Energy Technology Data Exchange (ETDEWEB)

    Eldred, Michael Scott; Subia, Samuel Ramirez; Neckels, David; Hopkins, Matthew Morgan; Notz, Patrick K.; Adams, Brian M.; Carnes, Brian; Wittwer, Jonathan W.; Bichon, Barron J.; Copps, Kevin D.

    2006-10-01

    This report documents the results for an FY06 ASC Algorithms Level 2 milestone combining error estimation and adaptivity, uncertainty quantification, and probabilistic design capabilities applied to the analysis and design of bistable MEMS. Through the use of error estimation and adaptive mesh refinement, solution verification can be performed in an automated and parameter-adaptive manner. The resulting uncertainty analysis and probabilistic design studies are shown to be more accurate, efficient, reliable, and convenient.

  2. An Optimization Index to Identify the optimal Design Solution of Bridges

    OpenAIRE

    Feng, Yue

    2014-01-01

    Structural optimization has become an important tool for structural designers, since it allows a better exploitation of material, thus decreasing structure self-weight and saving material costs. Moreover, it helps the designer to find innovative design solutions and structural forms that not only better exploit material but also give the structure higher aesthetic value from an architectural point of view. When applied to real scale structures like bridges, this approach leads to the definiti...

  3. Novel design of high voltage pulse source for efficient dielectric barrier discharge generation by using silicon diodes for alternating current

    Science.gov (United States)

    Truong, Hoa Thi; Hayashi, Misaki; Uesugi, Yoshihiko; Tanaka, Yasunori; Ishijima, Tatsuo

    2017-06-01

    This work focuses on design, construction, and optimization of configuration of a novel high voltage pulse power source for large-scale dielectric barrier discharge (DBD) generation. The pulses were generated by using the high-speed switching characteristic of an inexpensive device called silicon diodes for alternating current and the self-terminated characteristic of DBD. The operation started to be powered by a primary DC low voltage power supply flexibly equipped with a commercial DC power supply, or a battery, or DC output of an independent photovoltaic system without transformer employment. This flexible connection to different types of primary power supply could provide a promising solution for the application of DBD, especially in the area without power grid connection. The simple modular structure, non-control requirement, transformer elimination, and a minimum number of levels in voltage conversion could lead to a reduction in size, weight, simple maintenance, low cost of installation, and high scalability of a DBD generator. The performance of this pulse source has been validated by a load of resistor. A good agreement between theoretically estimated and experimentally measured responses has been achieved. The pulse source has also been successfully applied for an efficient DBD plasma generation.

  4. An Alternate Set of Basis Functions for the Electromagnetic Solution of Arbitrarily-Shaped, Three-Dimensional, Closed, Conducting Bodies Using Method of Moments

    Science.gov (United States)

    Mackenzie, Anne I.; Baginski, Michael E.; Rao, Sadasiva M.

    2008-01-01

    In this work, we present an alternate set of basis functions, each defined over a pair of planar triangular patches, for the method of moments solution of electromagnetic scattering and radiation problems associated with arbitrarily-shaped, closed, conducting surfaces. The present basis functions are point-wise orthogonal to the pulse basis functions previously defined. The prime motivation to develop the present set of basis functions is to utilize them for the electromagnetic solution of dielectric bodies using a surface integral equation formulation which involves both electric and magnetic cur- rents. However, in the present work, only the conducting body solution is presented and compared with other data.

  5. Thermal Alternating Polymer Nanocomposite (TAPNC) Coating Designed to Prevent Aerodynamic Insect Fouling

    Science.gov (United States)

    Bayer, Ilker S.; Krishnan, K. Ghokulla; Robison, Robert; Loth, Eric; Berry, Douglas H.; Farrell, Thomas E.; Crouch, Jeffrey D.

    2016-12-01

    Insect residue adhesion to moving surfaces such as turbine blades and aircraft not only causes surface contamination problems but also increases drag on these surfaces. Insect fouling during takeoff, climb and landing can result in increased drag and fuel consumption for aircraft with laminar-flow surfaces. Hence, certain topographical and chemical features of non-wettable surfaces need to be designed properly for preventing insect residue accumulation on surfaces. In this work, we developed a superhydrophobic coating that is able to maintain negligible levels of insect residue after 100 high speed (50 m/s) insect impact events produced in a wind tunnel. The coating comprises alternating layers of a hydrophobic, perfluorinated acrylic copolymer and hydrophobic surface functional silicon dioxide nanoparticles that are infused into one another by successive thermal treatments. The design of this coating was achieved as a result of various experiments conducted in the wind tunnel by using a series of superhydrophobic surfaces made by the combination of the same polymer and nanoparticles in the form of nanocomposites with varying surface texture and self-cleaning hydrophobicity properties. Moreover, the coating demonstrated acceptable levels of wear abrasion and substrate adhesion resistance against pencil hardness, dry/wet scribed tape peel adhesion and 17.5 kPa Taber linear abraser tests.

  6. Ab initio identified design principles of solid-solution strengthening in Al

    Directory of Open Access Journals (Sweden)

    Duancheng Ma, Martin Friák, Johann von Pezold, Dierk Raabe and Jörg Neugebauer

    2013-01-01

    Full Text Available Solid-solution strengthening in six Al–X binary systems is investigated using first-principle methods. The volumetric mismatch parameter and the solubility enthalpy per solute were calculated. We derive three rules for designing solid-solution strengthened alloys: (i the solubility enthalpy per solute is related to the volumetric mismatch by a power law; (ii for each annealing temperature, there exists an optimal solute–volume mismatch to achieve maximum strength; and (iii the strengthening potential of high volumetric mismatch solutes is severely limited by their low solubility. Our results thus show that the thermodynamic properties of the system (here Al–X alloys set clear upper bounds to the achievable strengthening effects owing to the reduced solubility with increasing volume mismatch.

  7. Femtosecond laser assisted design of sutureless intrastromal graft as an alternative to partial thickness keratoplasty

    Science.gov (United States)

    Rossi, Francesca; Durkee, Heather; Pini, Roberto; Canovetti, Annalisa; Malandrini, Alex; Lenzetti, Ivo; Rubino, Pierangela; Leaci, Rosachiara; Neri, Alberto; Scaroni, Patrizia; Menabuoni, Luca; Macaluso, Claudio

    2014-02-01

    Minimally invasive laser assisted surgery in ophthalmology is continuously developing in order to find new surgical approaches, preserve patient tissue and improve surgical results in terms of cut precision, restoration of visual acuity, and invasiveness. In order to achieve these goals, the current approach in corneal transplant is lamellar keratoplasty, where only the anterior or posterior part of the patient's cornea is substituted depending on the lesion or pathology. In this work, we present a novel alternative approach: a case study of intrastromal sutureless transplant, where a portion of the anterior stroma of a donor cornea was inserted into the stroma of the recipient cornea, aiming to restore the correct thickness of the patient's cornea. The patient cornea was paracentrally thin, as the result of a trophic ulcer due to ocular pemphigoid. A discoid corneal graft from the anterior stroma of a donor eye was prepared: a femtosecond laser cut with a trapezoidal profile (thickness was 300 μm, minor and major basis were 3.00 and 3.50 mm, respectively). In the recipient eye, an intrastromal cut was also performed with the femtosecond laser using a specifically designed mask; the cut position was 275 μm in depth. The graft was loaded into an injector and inserted as an intrastromal presbyopic implant. The postoperative analysis evidenced a clear and stable graft that selectively restored corneal thickness in the thinned area. Intrastromal corneal transplant surgery is a minimally invasive alternative to anterior or posterior lamellar keratoplasty in select cases. We believe that Sutureless Intrastromal Laser Keratoplasty (SILK) could open up new avenues in the field of corneal transplantation by fully utilizing the potential and precision of existing lasers.

  8. Data management for the internet of things: design primitives and solution.

    Science.gov (United States)

    Abu-Elkheir, Mervat; Hayajneh, Mohammad; Ali, Najah Abu

    2013-11-14

    The Internet of Things (IoT) is a networking paradigm where interconnected, smart objects continuously generate data and transmit it over the Internet. Much of the IoT initiatives are geared towards manufacturing low-cost and energy-efficient hardware for these objects, as well as the communication technologies that provide objects interconnectivity. However, the solutions to manage and utilize the massive volume of data produced by these objects are yet to mature. Traditional database management solutions fall short in satisfying the sophisticated application needs of an IoT network that has a truly global-scale. Current solutions for IoT data management address partial aspects of the IoT environment with special focus on sensor networks. In this paper, we survey the data management solutions that are proposed for IoT or subsystems of the IoT. We highlight the distinctive design primitives that we believe should be addressed in an IoT data management solution, and discuss how they are approached by the proposed solutions. We finally propose a data management framework for IoT that takes into consideration the discussed design elements and acts as a seed to a comprehensive IoT data management solution. The framework we propose adapts a federated, data- and sources-centric approach to link the diverse Things with their abundance of data to the potential applications and services that are envisioned for IoT.

  9. Design as a Problem and Design as a Solution for Sustainability

    DEFF Research Database (Denmark)

    Morelli, Nicola

    2012-01-01

    at the local level. This paper proposes a change in the design perspective that is strongly linked to a new approach to innovation in industrial production. Only a genetic change in the role of industrial production is likely to provide the radical changes required for a sustainable development. Consequently...... the design discipline particularly sensitive to the question of sustainability. In this context the need for a decisive change of perspective for designers is certainly a necessity, but can also be an opportunity to propose a new approach that can generate sustainable innovation and development, especially...... only a radically new design approach will be able to support such change....

  10. Selection of the variant solution of forest road alignment conceptual design using multicriteria optimisation

    Directory of Open Access Journals (Sweden)

    Stefanović Bogdan

    2009-01-01

    Full Text Available One of the three studied variant solutions of forest road conceptual design was selected based on the linear distribution of criteria, as the method of multicriteria optimization. The selection was performed with 25 parameters classified as economic, technical, production and social criteria. The parameters of technical criteria were grouped into design, construction and building parameters. Based on calculated nominal values of parameters by the given criteria, their ranking, comparison, point rating and scoring, the selected most favorable solution was variant 1.

  11. Fractional Factorial Design Study on the Performance of GAC-Enhanced Electrocoagulation Process Involved in Color Removal from Dye Solutions

    Directory of Open Access Journals (Sweden)

    Iuliana Gabriela Breaban

    2013-07-01

    Full Text Available The aim of this study was to determine the effects of main factors and interactions on the color removal performance from dye solutions using the electrocoagulation process enhanced by adsorption on Granular Activated Carbon (GAC. In this study, a mathematical approach was conducted using a two-level fractional factorial design (FFD for a given dye solution. Three textile dyes: Acid Blue 74, Basic Red 1, and Reactive Black 5 were used. Experimental factors used and their respective levels were: current density (2.73 or 27.32 A/m2, initial pH of aqueous dye solution (3 or 9, electrocoagulation time (20 or 180 min, GAC dose (0.1 or 0.5 g/L, support electrolyte (2 or 50 mM, initial dye concentration (0.05 or 0.25 g/L and current type (Direct Current—DC or Alternative Pulsed Current—APC. GAC-enhanced electrocoagulation performance was analyzed statistically in terms of removal efficiency, electrical energy, and electrode material consumptions, using modeling polynomial equations. The statistical significance of GAC dose level on the performance of GAC enhanced electrocoagulation and the experimental conditions that favor the process operation of electrocoagulation in APC regime were determined. The local optimal experimental conditions were established using a multi-objective desirability function method.

  12. Design as a Problem and Design as a Solution for Sustainability

    DEFF Research Database (Denmark)

    Morelli, Nicola

    2012-01-01

    the design discipline particularly sensitive to the question of sustainability. In this context the need for a decisive change of perspective for designers is certainly a necessity, but can also be an opportunity to propose a new approach that can generate sustainable innovation and development, especially...... at the local level. This paper proposes a change in the design perspective that is strongly linked to a new approach to innovation in industrial production. Only a genetic change in the role of industrial production is likely to provide the radical changes required for a sustainable development. Consequently...

  13. Strategic network design of Java Island fuel supply with production-transportation solution

    Science.gov (United States)

    Dianawati, Fauzia; Farizal, -; Surjandari, Isti; Marzuli, Rully

    2011-10-01

    This study aims to find more efficient supply network, from refineries / imports to fuel terminal, which still uses the Tanker, Tank Trucks or Rail Tank Wagon with an alternative pipeline that are considered more efficient than other transport modes, as well as gaining pipeline transportation network optimization analysis tailored to the capabilities/ capacity of refinery production and capacity of the pipe mode. With the complexity of the number of 3 point sources of supply, 19 destination of terminal, 4 kinds of products and 4 types of transport modes, transport-production model modified by adding multi-modal transport and investment costs of new pipeline. Then coded in Lingo program which adopts Branch & Bound technique and input the processed data in order to obtain an optimal distribution pattern produced the lowest distribution costs. This B&B solution was also compared with SCO solution which is a metaheuristic method. The results of this study lead to the development of new modes of pipeline connections in amount of 4 alternatives, generated from the optimal solution, but still potentially earned savings of about IDR 1 Trillion per year from cost-efficiency of product procurement and transportation costs.

  14. Design of Fogging Nozzles as Alternative Stock Pile Dust Suppression Medium at Gold Mining Sites

    Directory of Open Access Journals (Sweden)

    Stephen Kwasi Adzimah

    2012-01-01

    Full Text Available The aim of this study is to design fogging nozzles as alternative stock pile dust suppression medium at gold mining sites. Furthermore, this fogging medium helps to arrest the dust without getting the area wet and without any substantial expenditure. Emission of dust, which is one of the main contributors to the pollution of the environment, has been associated with mining industries for years, especially in the mining towns of Ghana and Liberia. The emission of dust takes place mainly around the haul roads, ore drilling, blasting and trafficking areas, crushers and, and especially, the stock pile unit. The intensity of the emissions of the dust is such that all the plants, objects, living things, gadgets, instruments and structures in the area are engulfed in the dust. Residents, who are hard hit by this phenomenon, backed by their traditional rulers often take the mining companies to task through legal or unlawful actions, which, many a time, become violent and confrontational. Sprinkling of water has been done to alleviate the situation but this process rather creates more problems in that, the area, especially roads, once wet becomes dry again, and the emission of dust gets intensified and aggravated.

  15. Three-dimensional analysis of the Pratt and Whitney alternate design SSME fuel turbine

    Science.gov (United States)

    Kirtley, K. R.; Beach, T. A.; Adamczyk, J. J.

    1991-01-01

    The three dimensional viscous time-mean flow in the Pratt and Whitney alternate design space shuttle main engine fuel turbine is simulated using the average passage Navier-Stokes equations. The migration of secondary flows generated by upstream blade rows and their effect on the performance of downstream blade rows is studied. The present simulation confirms that the flow in this two stage turbine is highly three dimensional and dominated by the tip leakage flow. The tip leakage vortex generated by the first blade persists through the second blade and adversely affects its performance. The greatest mixing of the inlet total temperature distortion occurs in the second vane and is due to the large leakage vortex generated by the upstream rotor. It is assumed that the predominant spanwise mixing mechanism in this low aspect ratio turbine is the radial transport due to the deterministically unsteady vortical flow generated by upstream blade rows. A by-product of the analysis is accurate pressure and heat loads for all blade rows under the influence of neighboring blade rows. These aero loads are useful for advanced structural analysis of the vanes and blades.

  16. Integrating DfM components into a cohesive design-to-silicon solution (Invited Paper)

    Science.gov (United States)

    Liebmann, Lars; Maynard, Dan; McCullen, Kevin; Seong, Nakgeuon; Buturla, Ed; Lavin, Mark; Hibbeler, Jason

    2005-05-01

    Two primary tracks of DfM, one originating from physical design characterization, the other from low-k1 lithography, are described. Examples of specific DfM efforts are given and potentially conflicting layout optimization goals are pointed out. The need for an integrated DfM solution than ties together currently parallel DfM efforts of increasing sophistication and layout impact is identified and a novel DfM-enabling design flow is introduced.

  17. SOA enabled ELTA: approach in designing business intelligence solutions in Era of Big Data

    Directory of Open Access Journals (Sweden)

    Viktor Dmitriyev

    2015-01-01

    Full Text Available The current work presents a new approach for designing business intelligence solutions. In the Era of Big Data, former and robust analytical concepts and utilities need to adapt themselves to the changed market circumstances. The main focus of this work is to address the acceleration of building process of a “data-centric” Business Intelligence (BI solution besides preparing BI solutions for Big Data utilization. This research addresses the following goals: reducing the time spent during business intelligence solution’s design phase; achieving flexibility of BI solution by adding new data sources; and preparing BI solution for utilizing Big Data concepts. This research proposes an extension of the existing Extract, Load and Transform (ELT approach to the new one Extract, Load, Transform and Analyze (ELTA supported by service-orientation concept. Additionally, the proposed model incorporates Service-Oriented Architecture concept as a mediator for the transformation phase. On one side, such incorporation brings flexibility to the BI solution and on the other side; it reduces the complexity of the whole system by moving some responsibilities to external authorities.

  18. Solution of Fifth Order Caudrey-Dodd-Gibbon-Sawada-Kotera Equation by the Alternative (G'/G-Expansion Method with Generalized Riccati Equation

    Directory of Open Access Journals (Sweden)

    Muhammad SHAKEEL

    2014-08-01

    Full Text Available In the present paper, the alternative (G'/G-expansion is used to find new and precise solutions of Caudrey-Dodd-Gibbon-Sawada-Kotera equation with the assist of symbolic computation Maple, in which the generalized Riccati equation is used as an auxiliary equation. Plentiful traveling wave solutions including; exponential, hyperbolic and trigonometric functions are successfully accomplished by the proposed method with capricious parameters. It is revealed that the proposed method is straightforward, constructive and many nonlinear evolution equations in mathematical physics are solved by this method.

  19. Analytical quality-by-design approach for sample treatment of BSA-containing solutions

    Institute of Scientific and Technical Information of China (English)

    Lien Taevernier; Evelien Wynendaele; Matthias D’Hondt; Bart De Spiegeleer

    2015-01-01

    The sample preparation of samples containing bovine serum albumin (BSA), e.g., as used in transdermal Franz diffusion cell (FDC) solutions, was evaluated using an analytical quality-by-design (QbD) approach. Traditional precipitation of BSA by adding an equal volume of organic solvent, often successfully used with conventional HPLC-PDA, was found insufficiently robust when novel fused-core HPLC and/or UPLC-MS methods were used. In this study, three factors (acetonitrile (%), formic acid (%) and boiling time (min)) were included in the experimental design to determine an optimal and more suitable sample treatment of BSA-containing FDC solutions. Using a QbD and Derringer desirability (D) approach, combining BSA loss, dilution factor and variability, we constructed an optimal working space with the edge of failure defined as Do0.9. The design space is modelled and is confirmed to have an ACN range of 8373%and FA content of 170.25%.

  20. Predictive Sampling of Rare Conformational Events in Aqueous Solution: Designing a Generalized Orthogonal Space Tempering Method.

    Science.gov (United States)

    Lu, Chao; Li, Xubin; Wu, Dongsheng; Zheng, Lianqing; Yang, Wei

    2016-01-12

    analysis suggests that because essential conformational events are mainly driven by the compensating fluctuations of essential solute-solvent and solute-solute interactions, commonly employed "predictive" sampling methods are unlikely to be effective on this seemingly "simple" system. The gOST development presented in this paper illustrates how to employ the OSS scheme for physics-based sampling method designs.

  1. Wood slabs as a proposed solution to the design and construction of pavement

    Directory of Open Access Journals (Sweden)

    Carlos Alfonso Devia Castillo

    2016-01-01

    Full Text Available Alternatives to replace concrete slabs for prefabricated wood as structure of pavement with wearing course was evaluated, ensuring that these prefabrications work as a single element using finger joints. The mechanical behavior of two types of wood identified through simulations implementing a method of finite elements was evaluated, to subsequently determined optimal configuration for the alternative design with wood pavements and finally verified in the laboratory with the optimal configuration determined with simulation for a design of 440 000 vehicles shafts, with the use of the MTS machine and a load of 6.50 tons equivalent to a load of a single axle shaft with two wheels, found that for different traffic design the thickness of the slab of wood to resist this load varies between 0.125 and 0.24 meters. This research shows that prefabricated wood building systems are a viable alternative in the market for pavement construction in the structural sense; additionally, they are an innovation since they modify the structural system of slabs, conventionally built on concrete slabs and reduce environmental impact.

  2. Evaluation of Alternate Materials and Methods for Strontium and Alpha Removal from Savannah River Site High-Level Waste Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Hobbs, D.T.

    2000-11-07

    A literature survey indicated a number of alternate materials and methods for the removal of strontium and alpha-emitting radionuclides (actinides). We evaluated the use of alternate materials versus proposed flowsheets for salt processing at the Savannah River Site (SRS). From this evaluation we recommend the following materials for further testing to determine the rate and extent of removal. We do not recommend testing of liquid/liquid extraction and polymer filtration methods at this time.

  3. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    Science.gov (United States)

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  4. Сomparative Analysis of Sounding Range for Aerosol Lidar Alternate Designs

    Directory of Open Access Journals (Sweden)

    S. E. Ivanov

    2015-01-01

    Full Text Available The aerosol lidars intended for expeditious monitoring of the atmosphere allow us to define remotely characteristics of atmospheric aerosol and cloudy formations in the atmosphere. When designing the laser systems, one of the first tasks to be solved is to determine a potential range of laser system operation. The laser system operation range depends on the algorithm for processing laser signals used in laser system. It can be estimated from an equality condition (for the limit range between the power characteristics of the useful laser signal (coming to the receiver and the threshold power characteristics of the laser system receiver. Today, practically, all the existing aerosol lidars operate with rather low repetition rate and with rather powerful single pulses. An alternative to it is operation with high repetition rate and with a low power of single pulses. The paper presents comparative analysis of a sounding range for the Aerosol Lidar in UF (0.355 microns, visible (0.532 microns and near infrared (1.064 microns spectral ranges for various lidar options (with different repetition rates of laser pulses and different algorithms to process laser locational signals. To estimate the limit sounding ranges L three different algorithms were used: - equality of useful signal power and threshold power of the receiver; equality of useful signal power in the no-accumulation mode and minimum detected (threshold power in the no-accumulation mode; equality of useful signal power in the accumulation mode and minimum detected (threshold power in the accumulation mode. Results of mathematical modelling show that the signals accumulation mode provides significantly longer sounding range, than the signals no-accumulation mode. The limit sounding range in the mode of signals accumulation is defined by dependence of the laser pulse power on the repetition rate.

  5. Differential Evolution Algorithm Based Solution Approaches for Solving Transportation Network Design Problems

    Directory of Open Access Journals (Sweden)

    Özgür Başkan

    2014-09-01

    Full Text Available Differential Evolution algorithm has effectively been used to solve engineering optimization problems recently. The Differential Evolution algorithm, which uses similar principles with Genetic Algorithms, is more robust on obtaining optimal solution than many other heuristic algorithms with its simpler structure. In this study, Differential Evolution algorithm is applied to the transportation network design problems and its effectiveness on the solution is investigated. In this context, Differential Evolution based models are developed using bi-level programming approach for the solution of the transportation network design problem and determination of the on-street parking places in urban road networks. In these models, optimal investment and parking strategies are investigated on the upper level. On the lower level, deterministic traffic assignment problem, which represents drivers' responses, is solved using Frank-Wolfe algorithm and VISUM traffic modeling software. In order to determine the effectiveness of the proposed models, numerical applications are carried out on Sioux-Falls test network. Results showed that the Differential Evolution algorithm may effectively been used for the solution of transportation network design problems.

  6. Diclofenac sodium topical solution with dimethyl sulfoxide, a viable alternative to oral nonsteroidal anti-inflammatories in osteoarthritis: review of current evidence

    OpenAIRE

    Fuller P; Roth SH

    2011-01-01

    Philip Fuller¹, Sanford Roth²¹Covidien, Hazelwood, MO; ²Arizona Research and Education, Arthritis Research Laboratory, Arizona State University, Phoenix, AZ, USAAbstract: Topical nonsteroidal anti-inflammatory drugs (NSAIDs) may offer a safer alternative to their oral counterparts for the management of osteoarthritis. Diclofenac sodium topical solution with dimethyl sulfoxide (TDiclo) was evaluated in five randomized, controlled trials and is indicated for ...

  7. Consideration of alternative designs for a Percutaneous Endoscopic Gastrostomy feeding tube

    Science.gov (United States)

    Yerrabolu, Santosh Rohit

    The inability of some people to chew or swallow foods (but can digest foods) due to problems associated with various diseases and complications leads them to insufficient nutritional intake and loss of quality of life. These individuals are generally provided with nutritional support by means of injecting or infusing food directly into their stomachs or small intestines via feeding tubes. Gastrostomy feeding tubes (G-tubes) are used when such nutritional support is required for over 3-6 weeks. Percutaneous Endoscopic Gastrostomy (PEG) tubes are one of the most widely used G- Tubes and devices which are inserted via an incision through the abdominal wall either through a pull or push method. This investigation proposes conceptual alternative Percutaneous Endoscopy Gastrostomy (PEG) feeding tube designs with optimized materials selection to be used for their construction. The candidate materials were chosen from 18 commercial catheters, 2 reference grade polymers and a commercial polymer; using tissue-catheter-friction testing and surface chemistry characterization (Infrared spectroscopy and Critical Surface Tension approximation). The main objectives considered were to minimize slipping/dislodgement of gastrostomy tube/seal, to reduce peristomal leakage, and to attain size variability of PEG tubes while maintaining a low profile. Scanning Electron Microscope- Energy Dispersive X-ray Spectroscopy was employed to further determine the filler materials used in the samples. Nylon coated with fatty ester and filled with Barium sulphate was determined as the optimum material for the construction of the tube part of the feeding tubes to reduce slipping/dislodgment of gastrostomy tube/seal and to minimize peristomal leakage. Nylon coated with fatty ester and filled with Silica is the suggested as a candidate material for construction of the bumper/mushroom sections of the feeding tubes to avoid the Buried Bumper Syndrome. Fused Deposition Modeling, Selective Laser Sintering

  8. Update and Improve Subsection NH –– Alternative Simplified Creep-Fatigue Design Methods

    Energy Technology Data Exchange (ETDEWEB)

    Tai Asayama

    2009-10-26

    This report described the results of investigation on Task 10 of DOE/ASME Materials NGNP/Generation IV Project based on a contract between ASME Standards Technology, LLC (ASME ST-LLC) and Japan Atomic Energy Agency (JAEA). Task 10 is to Update and Improve Subsection NH -- Alternative Simplified Creep-Fatigue Design Methods. Five newly proposed promising creep-fatigue evaluation methods were investigated. Those are (1) modified ductility exhaustion method, (2) strain range separation method, (3) approach for pressure vessel application, (4) hybrid method of time fraction and ductility exhaustion, and (5) simplified model test approach. The outlines of those methods are presented first, and predictability of experimental results of these methods is demonstrated using the creep-fatigue data collected in previous Tasks 3 and 5. All the methods (except the simplified model test approach which is not ready for application) predicted experimental results fairly accurately. On the other hand, predicted creep-fatigue life in long-term regions showed considerable differences among the methodologies. These differences come from the concepts each method is based on. All the new methods investigated in this report have advantages over the currently employed time fraction rule and offer technical insights that should be thought much of in the improvement of creep-fatigue evaluation procedures. The main points of the modified ductility exhaustion method, the strain range separation method, the approach for pressure vessel application and the hybrid method can be reflected in the improvement of the current time fraction rule. The simplified mode test approach would offer a whole new advantage including robustness and simplicity which are definitely attractive but this approach is yet to be validated for implementation at this point. Therefore, this report recommends the following two steps as a course of improvement of NH based on newly proposed creep-fatigue evaluation

  9. A STACKELBERG DIFFERENTIAL GAMES SOLUTION TO A PROBLEM OF OPTIMAL INTERTEMPORAL INVESTMENT AND TAX RATE DESIGN

    Institute of Scientific and Technical Information of China (English)

    ZHANG Rong; LIU Xing

    2004-01-01

    Using the Stackelberg differential games(SDG) theory, we quantitatively study a problem of optimal intertemporal investment and tax rate design. Under some appropriate assumptions, the open-loop Stackelberg equilibrium solutions are obtained. Equilibrium solutions show that: 1. The optimal strategies derived from differential game and unilateral optimal control approaches are different; 2. It is not always the best strategy for the government to use a constant tax rate over the whole time period; 3. The admissible size of tax rate adjustment may have great effect on the government's optimal strategy; 4.SDG approach has no significant effect on the firm's optimal investment strategy.

  10. A Design Alternative to Improve the Interconnection Capability of New Distributed-Generation Installations into Existing Griddle

    OpenAIRE

    2016-01-01

    Most distributed-generation facilities are performed on pre-built distribution grids. The design conditions of these existing grids may limit the ability of new users to get a connection due to technical and/or cost constraints. This work proposes a simple solution, adjusted to the relevant regulations and embodied in a radial distribution grid of Spanish low voltage, to improve the interconnection of distributed generation, usually grid connected photovoltaic systems. The proposed solution, ...

  11. SOLUTIONING

    Directory of Open Access Journals (Sweden)

    Maria de Hoyos Guajardo, Ph.D. Candidate, M.Sc., B.Eng.

    2004-11-01

    Full Text Available The theory that is presented below aims to conceptualise how a group of undergraduate students tackle non-routine mathematical problems during a problem-solving course. The aim of the course is to allow students to experience mathematics as a creative process and to reflect on their own experience. During the course, students are required to produce a written ‘rubric’ of their work, i.e., to document their thoughts as they occur as well as their emotionsduring the process. These ‘rubrics’ were used as the main source of data.Students’ problem-solving processes can be explained as a three-stage process that has been called ‘solutioning’. This process is presented in the six sections below. The first three refer to a common area of concern that can be called‘generating knowledge’. In this way, generating knowledge also includes issues related to ‘key ideas’ and ‘gaining understanding’. The third and the fourth sections refer to ‘generating’ and ‘validating a solution’, respectively. Finally, once solutions are generated and validated, students usually try to improve them further before presenting them as final results. Thus, the last section deals with‘improving a solution’. Although not all students go through all of the stages, it may be said that ‘solutioning’ considers students’ main concerns as they tackle non-routine mathematical problems.

  12. New morphing blade section designs and structural solutions for smart blades

    DEFF Research Database (Denmark)

    Karakalas, Anargyros A.; Machairas, Theodore; Solomou, Alexandros

    2015-01-01

    and manufacturing processes constraints. Down selection of design based on results of analysis (for input to Task 2.3) was also performed. Following solutions were investigated:  Morphing blade sections with Shape Memory Alloys (SMA) by University of Patras  Morphing blade sections using an elastomer of zero...... Poisson ratio by University of Bristol  Morphing blade sections involving an innovative mechanism by Denmarks University of Technology The work performed on these three concepts is described in individual chapters of the present report. Section 2 discusses the concept using shape memory alloys, section 3...... of the present report. The solutions using Shape Memory Alloys, as well as an elastomer of zero Poisson ratio have a quite low technological readiness level (TRL). Both are inspired through the aeronautics sector, yet there are different challenges to address when designing for wind turbine blades. The size...

  13. Cellulosic fuel ethanol: alternative fermentation process designs with wild-type and recombinant Zymomonas mobilis.

    Science.gov (United States)

    Lawford, Hugh G; Rousseau, Joyce D

    2003-01-01

    Iogen (Canada) is a major manufacturer of industrial cellulase and hemicellulase enzymes for the textile, pulp and paper, and poultry feed industries. Iogen has recently constructed a 40 t/d biomass-to-ethanol demonstration plant adjacent to its enzyme production facility. The integration of enzyme and ethanol plants results in significant reduction in production costs and offers an alternative use for the sugars generated during biomass conversion. Iogen has partnered with the University of Toronto to test the fermentation performance characteristics of metabolically engineered Zymomonas mobilis created at the National Renewable Energy Laboratory. This study focused on strain AX101, a xylose- and arabinose-fermenting stable genomic integrant that lacks the selection marker gene for antibiotic resistance. The "Iogen Process" for biomass depolymerization consists of a dilute-sulpfuric acid-catalyzed steam explosion, followed by enzymatic hydrolysis. This work examined two process design options for fermentation, first, continuous cofermentation of C5 and C6 sugars by Zm AX101, and second, separate continuous fermentations of prehydrolysate by Zm AX101 and cellulose hydrolysate by either wildtype Z. mobilis ZM4 or an industrial yeast commonly used in the production of fuel ethanol from corn. Iogen uses a proprietary process for conditioning the prehydrolysate to reduce the level of inhibitory acetic acid to at least 2.5 g/L. The pH was controlled at 5.5 and 5.0 for Zymomonas and yeast fermentations, respectively. Neither 2.5 g/L of acetic acid nor the presence of pentose sugars (C6:C5 = 2:1) appreciably affected the high-performance glucose fermentation of wild-type Z. mobilis ZM4. By contrast, 2.5 g/L of acetic acid significantly reduced the rate of pentose fermentation by strain AX101. For single-stage continuous fermentation of pure sugar synthetic cellulose hydrolysate (60 g/L of glucose), wild-type Zymomonas exhibited a four-fold higher volumetric productivity

  14. Concurrent engineering solution for the design of ship and offshore bracket parts and fabrication process

    Science.gov (United States)

    Kim, Tae-Won; Lim, Sang-Sub; Seok, Ho-Hyun; Kang, Chung-Gil

    2013-09-01

    Brackets in ships and offshore structures are added structures that can endure stress concentrations. In this study, a concurrent engineering solution was proposed, and a high strength low carbon cast steel alloy applicable to offshore structures was designed and developed. The yield strength and ultimate tensile strength of the designed steel were 480 and 600 MPa, respectively. The carbon equivalent of the steel was 0.446 with a weld crack susceptibility index of 0.219. The optimal structural design of the brackets for offshore structures was evaluated using ANSYS commercial software. The possibility of replacing an assembly of conventional built-up brackets with a single casting bulb bracket was verified. The casting process was simulated using MAGMAsoft commercial software, and a casting fabrication process was designed. For the proposed bulb bracket, it was possible to reduce the size and weight by approximately 30% and 50%, respectively, compared to the conventional type of bracket.

  15. Optimal Solution for VLSI Physical Design Automation Using Hybrid Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    I. Hameem Shanavas

    2014-01-01

    Full Text Available In Optimization of VLSI Physical Design, area minimization and interconnect length minimization is an important objective in physical design automation of very large scale integration chips. The objective of minimizing the area and interconnect length would scale down the size of integrated chips. To meet the above objective, it is necessary to find an optimal solution for physical design components like partitioning, floorplanning, placement, and routing. This work helps to perform the optimization of the benchmark circuits with the above said components of physical design using hierarchical approach of evolutionary algorithms. The goal of minimizing the delay in partitioning, minimizing the silicon area in floorplanning, minimizing the layout area in placement, minimizing the wirelength in routing has indefinite influence on other criteria like power, clock, speed, cost, and so forth. Hybrid evolutionary algorithm is applied on each of its phases to achieve the objective. Because evolutionary algorithm that includes one or many local search steps within its evolutionary cycles to obtain the minimization of area and interconnect length. This approach combines a hierarchical design like genetic algorithm and simulated annealing to attain the objective. This hybrid approach can quickly produce optimal solutions for the popular benchmarks.

  16. Differential Reinforcement of Alternative Behavior Increases Resistance to Extinction: Clinical Demonstration, Animal Modeling, and Clinical Test of One Solution

    Science.gov (United States)

    Mace, F. Charles; McComas, Jennifer J.; Mauro, Benjamin C.; Progar, Patrick R.; Taylor, Bridget; Ervin, Ruth; Zangrillo, Amanda N.

    2010-01-01

    Basic research with pigeons on behavioral momentum suggests that differential reinforcement of alternative behavior (DRA) can increase the resistance of target behavior to change. This finding suggests that clinical applications of DRA may inadvertently increase the persistence of target behavior even as it decreases its frequency. We conducted…

  17. Turbo-alternator-compressor design for supercritical high density working fluids

    Science.gov (United States)

    Wright, Steven A.; Fuller, Robert L.

    2013-03-19

    Techniques for generating power are provided. Such techniques involve a thermodynamic system including a housing, a turbine positioned in a turbine cavity of the housing, a compressor positioned in a compressor cavity of the housing, and an alternator positioned in a rotor cavity between the turbine and compressor cavities. The compressor has a high-pressure face facing an inlet of the compressor cavity and a low-pressure face on an opposite side thereof. The alternator has a rotor shaft operatively connected to the turbine and compressor, and is supported in the housing by bearings. Ridges extending from the low-pressure face of the compressor may be provided for balancing thrust across the compressor. Seals may be positioned about the alternator for selectively leaking fluid into the rotor cavity to reduce the temperature therein.

  18. A comparative analysis for multiattribute selection among renewable energy alternatives using fuzzy axiomatic design and fuzzy analytic hierarchy process

    Energy Technology Data Exchange (ETDEWEB)

    Kahraman, Cengiz; Kaya, Ihsan; Cebi, Selcuk [Istanbul Technical University, Department of Industrial Engineering, 34367, Macka-Istanbul (Turkey)

    2009-10-15

    Renewable energy is the energy generated from natural resources such as sunlight, wind, rain, tides and geothermal heat which are renewable. Energy resources are very important in perspective of economics and politics for all countries. Hence, the selection of the best alternative for any country takes an important role for energy investments. Among decision-making methodologies, axiomatic design (AD) and analytic hierarchy process (AHP) are often used in the literature. The fuzzy set theory is a powerful tool to treat the uncertainty in case of incomplete or vague information. In this paper, fuzzy multicriteria decision- making methodologies are suggested for the selection among renewable energy alternatives. The first methodology is based on the AHP which allows the evaluation scores from experts to be linguistic expressions, crisp, or fuzzy numbers, while the second is based on AD principles under fuzziness which evaluates the alternatives under objective or subjective criteria with respect to the functional requirements obtained from experts. The originality of the paper comes from the fuzzy AD application to the selection of the best renewable energy alternative and the comparison with fuzzy AHP. In the application of the proposed methodologies the most appropriate renewable energy alternative is determined for Turkey. (author)

  19. Design analysis of fixed-pitch straight-bladed vertical axis wind turbines with an alternative material

    Energy Technology Data Exchange (ETDEWEB)

    Islam, M.; Ting, D.S.K.; Fartaj, A. [Windsor Univ., ON (Canada). Dept. of Mechanical, Automotive and Materials Engineering; Ahmed, F.U. [Lambton College of Applied Arts and Technology, Sarnia, ON (Canada)

    2008-07-01

    Most blades in fixed-pitch straight-bladed vertical axis wind turbine (SB-VAWT) are made of aluminium. However, in order for wind energy to be cost competitive, the blades must be produced at moderate cost. The blades should also last between 20 and 30 years, which is the predicted service life of these mechanically uncomplicated turbomachines. The primary disadvantage of using aluminium alloy for wind turbine application is its poor fatigue properties. Its allowable stress levels in dynamic application also decrease significantly at increasing numbers of cyclic stress applications. For that reason, this study investigated alternative materials for SB-VAWT blades. The properties of the SB-VAWT blade materials were identified in this paper along with prospective materials. Comparisons were then made between the available materials based on their mechanical properties and costs. The most attractive alternative material was then chosen for a detailed design analysis using an analytical tool. The design features of an SB-VAWT with aluminium and pultruded fiberglass reinforced plastic (FRP) blades were then compared using one of the prospective airfoils. The alternative blade material was found to be superior to the conventionally used aluminum. It was concluded that pultruded FRP is a prospective alternative blade material for SB-VAWTs. 9 refs., 2 tabs., 1 fig.

  20. An optimization model and solution for radiation shielding design of radiotherapy treatment vaults.

    Science.gov (United States)

    Newman, Francis; Asadi-Zeydabadi, Masoud

    2008-01-01

    In radiation shielding design, one is usually faced with a set of conflicting goals that are navigated by an experienced physicist. If one has abundant space, the task is simplified because concrete is relatively inexpensive and will provide adequate shielding for high energy photons and neutrons, when applicable. However, if space is constrained (which is usually the case), the design becomes more difficult since one will likely have to employ combinations of steel, lead, and concrete, or other new materials--each with different properties and costs. Very experienced shielding designers can draw upon previous plans, but they do not know if their design is optimal in any sense. We have constructed a linear program that minimizes the cost of the shielding materials and minimizes the dose at the protection point or the shielding thickness subject to space constraints and to Federal or State regulations regarding the allowable exposure to individuals adjacent to the radiotherapy vault. In spite of what appears to be a simple model, the solution may require iterations of the optimization to arrive at the optimal solution.

  1. Problems and their solutions in practical application of Eurocodes in seismic design of RC structures

    Directory of Open Access Journals (Sweden)

    Milev Jordan

    2016-01-01

    Full Text Available The main purpose of the paper is to present practical application of Eurocodes in the field of RC structures design. The selected examples represent the main problems in practical application of Eurocodes for seismic analysis and design of RC Structures in Bulgarian construction practice. The analysis is focused on some structural and economic problems as well as on some contradictions in Eurocode 8 itself. Special attention is paid to the practical solution of the following problems: recognition of torsionally flexible systems, stiffness reduction of RC elements for linear analysis dimensions and detailing of confined boundary areas of shear walls, detailing of wall structures, etc. Those problems appear during the practical design of some buildings in Bulgaria. Several proposals for solving some problems defined in the paper are presented through some practical examples. Some conclusions are made for further application of Eurocode 8 in the design and construction practice. The importance of some rules and procedures in Eurocode 8 is supported by the examples of damaged RC members during the past earthquakes. The problems of Eurocode 8 and their solutions are illustrated through the experience of Bulgarian construction practice.

  2. How a charge conserving alternative to Maxwells displacement current entails a Darwin like approximation to the solutions of Maxwells equations

    CERN Document Server

    Wolsky, Alan M

    2014-01-01

    Though sufficient for local conservation of charge, Maxwells displacement current is not necessary. An alternative to the Ampere-Maxwell equation is exhibited and the alternatives electric and magnetic fields and scalar and vector potentials are expressed in terms of the charge and current densities. The magnetic field is shown to satisfy the Biot_Savart Law. The electric field is shown to be the sum of the gradient of a scalar potential and the time derivative of a vector potential which is different from but just as tractable as the simplest vector potential that yields the Biot_Savart Law The alternative describes a theory in which action is instantaneous and so may provide a good approximation to Maxwells equations where and when the finite speed of light can be neglected. The result recalls the Darwin approximation which arose from the study classical charged point particles to order (v/c)2 in the Lagrangian. Unlike Darwin, this approach does not depend on the constitution of the electric current. Instea...

  3. The ChemScreen project to design a pragmatic alternative approachto predict reproductive toxicity of chemicals

    NARCIS (Netherlands)

    Van der Burg, B.; Wedebye, E.B.; Dietrich, D.R.; Jaworska, J.; Mangelsdorf, I.; Paune, E.; Schwarz, M.; Piersma, A.H.; Kroese, E.D.

    2015-01-01

    There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use.The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner prefer-ably using validated existing tools and place them in an innovative alternative testing

  4. Design and control of an alternative distillation sequence for bioethanol purification

    DEFF Research Database (Denmark)

    Errico, Massimiliano; Ramírez-Márquez, César; Torres Ortega, Carlo Edgar

    2015-01-01

    BACKGROUND: Bioethanol is a green fuel considered to be a sustainable alternative to petro-derived gasoline. The transport sector contributes significantly to carbon dioxide emission and consequently has a negative impact on the air quality and is responsible for the increase of the greenhouse...

  5. The ChemScreen project to design a pragmatic alternative approachto predict reproductive toxicity of chemicals

    NARCIS (Netherlands)

    Van der Burg, B.; Wedebye, E.B.; Dietrich, D.R.; Jaworska, J.; Mangelsdorf, I.; Paune, E.; Schwarz, M.; Piersma, A.H.; Kroese, E.D.

    2015-01-01

    There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use.The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner prefer-ably using validated existing tools and place them in an innovative alternative testing strategy

  6. MODELING AND DESIGN STUDY USING HFC-236EA AS AN ALTERNATIVE REFRIGERANT IN A CENTRIFUGAL COMPRESSOR

    Science.gov (United States)

    The report gives results of an investigation of the operation of a centrifugal compressor--part of a chlorofluorocarbon (CFC)-114 chiller installation--with the new refrigerant hydrofluorocarbon (HFC)-236ea, a proposed alternative to CFC-114. A large set of CFC-236ea operating da...

  7. Marriage, Abortion, or Unwed Motherhood? How Women Evaluate Alternative Solutions to Premarital Pregnancies in Japan and the United States

    Science.gov (United States)

    Hertog, Ekaterina; Iwasawa, Miho

    2011-01-01

    In this article, the authors argue that to understand the very low incidence of outside-of-marriage childbearing in contemporary Japan one needs to take into account perceptions of all possible solutions to a premarital pregnancy: marriage, abortion, and childbearing outside wedlock. To demonstrate the particular impact of these perceptions in…

  8. Marriage, Abortion, or Unwed Motherhood? How Women Evaluate Alternative Solutions to Premarital Pregnancies in Japan and the United States

    Science.gov (United States)

    Hertog, Ekaterina; Iwasawa, Miho

    2011-01-01

    In this article, the authors argue that to understand the very low incidence of outside-of-marriage childbearing in contemporary Japan one needs to take into account perceptions of all possible solutions to a premarital pregnancy: marriage, abortion, and childbearing outside wedlock. To demonstrate the particular impact of these perceptions in…

  9. An Alternative View of the Instructional Design Process: A Response to Smith and Boling

    Science.gov (United States)

    Gibbons, Andrew S.; Yanchar, Stephen C.

    2010-01-01

    A recent literature review by Smith and Boling (2009) critically examines the received view of instructional design in educational technology. Smith and Boling conclude that the foundational literature characterizes design in a way that leads to a constrained understanding of design, especially by novices. They suggest that as a field we move…

  10. Physics and engineering studies on the MITICA accelerator: comparison among possible design solutions

    Science.gov (United States)

    Agostinetti, P.; Antoni, V.; Cavenago, M.; Chitarin, G.; Pilan, N.; Marcuzzi, D.; Serianni, G.; Veltri, P.

    2011-09-01

    Consorzio RFX in Padova is currently using a comprehensive set of numerical and analytical codes, for the physics and engineering design of the SPIDER (Source for Production of Ion of Deuterium Extracted from RF plasma) and MITICA (Megavolt ITER Injector Concept Advancement) experiments, planned to be built at Consorzio RFX. This paper presents a set of studies on different possible geometries for the MITICA accelerator, with the objective to compare different design concepts and choose the most suitable one (or ones) to be further developed and possibly adopted in the experiment. Different design solutions have been discussed and compared, taking into account their advantages and drawbacks by both the physics and engineering points of view.

  11. Closed-form Solution to Directly Design FACE Waveforms for Beampatterns Using Planar Array

    KAUST Repository

    Bouchoucha, Taha

    2015-04-19

    In multiple-input multiple-output radar systems, it is usually desirable to steer transmitted power in the region-of-interest. To do this, conventional methods optimize the waveform covariance matrix, R, for the desired beampattern, which is then used to generate actual transmitted waveforms. Both steps require constrained optimization, therefore, use iterative algorithms. The main challenges encountered in the existing approaches are the computational complexity and the design of waveforms to use in practice. In this paper, we provide a closed-form solution to design covariance matrix for the given beampattern using the planar array, which is then used to derive a novel closed-form algorithm to directly design the finite-alphabet constant-envelope (FACE) waveforms. The proposed algorithm exploits the two-dimensional fast-Fourier-transform. The performance of our proposed algorithm is compared with existing methods that are based on semi-definite quadratic programming with the advantage of a considerably reduced complexity.

  12. Design and Construction Solutions in the Accurate Realization of NCSX Magnetic Fields

    Energy Technology Data Exchange (ETDEWEB)

    Heitzenroeder, P.; Dudek, Lawrence E.; Brooks, Arthur W.; Viola, Michael E.; Brown, Thomas; Neilson, George H.; Zarnstorff, Michael C.; Rej, Donald; Cole,Michael J.; Freudenberg, Kevin D.; Harris J. H.; McGinnis, Gary

    2008-09-29

    The National Compact Stellarator Experiment, NCSX, is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in partnership with the Oak Ridge national Laboratory. The goal of NCSX is to provide the understanding necessary to develop an attractive, disruption free, steady state compact stellaratorbased reactor design. This paper describes the recently revised designs of the critical interfaces between the modular coils, the construction solutions developed to meet assembly tolerances, and the recently revised trim coil system that provides the required compensation to correct for the “as built” conditions and to allow flexibility in the disposition of as-built conditions. In May, 2008, the sponsor decided to terminate the NCSX project due to growth in the project’s cost and schedule estimates. However significant technical challenges in design and construction were overcome, greatly reducing the risk in the remaining work to complete the project.

  13. Buffer-free therapeutic antibody preparations provide a viable alternative to conventionally buffered solutions: from protein buffer capacity prediction to bioprocess applications.

    Science.gov (United States)

    Bahrenburg, Sven; Karow, Anne R; Garidel, Patrick

    2015-04-01

    Protein therapeutics, including monoclonal antibodies (mAbs), have significant buffering capacity, particularly at concentrations>50 mg/mL. This report addresses pH-related issues critical to adoption of self-buffered monoclonal antibody formulations. We evaluated solution conditions with protein concentrations ranging from 50 to 250 mg/mL. Samples were both buffer-free and conventionally buffered with citrate. Samples were non-isotonic or adjusted for isotonicity with NaCl or trehalose. Studies included accelerated temperature stability tests, shaking stability studies, and pH changes in infusion media as protein concentrate is added. We present averaged buffering slopes of capacity that can be applied to any mAb and present a general method for calculating buffering capacity of buffer-free, highly concentrated antibody liquid formulations. In temperature stability tests, neither buffer-free nor conventionally buffered solution conditions showed significant pH changes. Conventionally buffered solutions showed significantly higher opalescence than buffer-free ones. In general, buffer-free solution conditions showed less aggregation than conventionally buffered solutions. Shaking stability tests showed no differences between buffer-free and conventionally buffered solutions. "In-use" preparation experiments showed that pH in infusion bag medium can rapidly approximate that of self-buffered protein concentrate as concentrate is added. In summary, the buffer capacity of proteins can be predicted and buffer-free therapeutic antibody preparations provide a viable alternative to conventionally buffered solutions. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Power-Aware Routing and Network Design with Bundled Links: Solutions and Analysis

    Directory of Open Access Journals (Sweden)

    Rosario G. Garroppo

    2013-01-01

    Full Text Available The paper deeply analyzes a novel network-wide power management problem, called Power-Aware Routing and Network Design with Bundled Links (PARND-BL, which is able to take into account both the relationship between the power consumption and the traffic throughput of the nodes and to power off both the chassis and even the single Physical Interface Card (PIC composing each link. The solutions of the PARND-BL model have been analyzed by taking into account different aspects associated with the actual applicability in real network scenarios: (i the time for obtaining the solution, (ii the deployed network topology and the resulting topology provided by the solution, (iii the power behavior of the network elements, (iv the traffic load, (v the QoS requirement, and (vi the number of paths to route each traffic demand. Among the most interesting and novel results, our analysis shows that the strategy of minimizing the number of powered-on network elements through the traffic consolidation does not always produce power savings, and the solution of this kind of problems, in some cases, can lead to spliting a single traffic demand into a high number of paths.

  15. A Design Alternative to Improve the Interconnection Capability of New Distributed-Generation Installations into Existing Griddle

    Directory of Open Access Journals (Sweden)

    José Agüero-Rubio

    2016-05-01

    Full Text Available Most distributed-generation facilities are performed on pre-built distribution grids. The design conditions of these existing grids may limit the ability of new users to get a connection due to technical and/or cost constraints. This work proposes a simple solution, adjusted to the relevant regulations and embodied in a radial distribution grid of Spanish low voltage, to improve the interconnection of distributed generation, usually grid connected photovoltaic systems. The proposed solution, based on increasing the section of the neutral line, achieves a capacity of increasing the length of the supply grid by more than 20%.

  16. Flight simulator requirements for airline transport pilot training - An evaluation of motion system design alternatives

    Science.gov (United States)

    Lee, A. T.; Bussolari, S. R.

    1986-01-01

    The effect of motion platform systems on pilot behavior is considered with emphasis placed on civil aviation applications. A dynamic model for human spatial orientation based on the physiological structure and function of the human vestibular system is presented. Motion platform alternatives were evaluated on the basis of the following motion platform conditions: motion with six degrees-of-freedom required for Phase II simulators and two limited motion conditions. Consideration was given to engine flameout, airwork, and approach and landing scenarios.

  17. DESIGNING CULTURALLY CONSCIOUS ALTERNATIVE DISPUTE RESOLUTION TO FOSTER ASIAN ECONOMIC DEVELOPMENT

    OpenAIRE

    Herliana, Mrs.

    2011-01-01

    Creating an Asian model of alternative dispute resolution which considers Asian cultures is important. A mere adoption of western standard will less likely accommodate Asian’s unique way of handling disputes. Culture-related problems can be avoided if international commercial mediation or arbitration is tuned in to cultural needs and expectations. Penyusunan model alternatif penyelesaian sengketa gaya Asia yang mengakomodasi budaya setempat penting untuk dilakukan. Penerapan standar barat ti...

  18. Design principles for high-pressure force fields: Aqueous TMAO solutions from ambient to kilobar pressures

    Science.gov (United States)

    Hölzl, Christoph; Kibies, Patrick; Imoto, Sho; Frach, Roland; Suladze, Saba; Winter, Roland; Marx, Dominik; Horinek, Dominik; Kast, Stefan M.

    2016-04-01

    Accurate force fields are one of the major pillars on which successful molecular dynamics simulations of complex biomolecular processes rest. They have been optimized for ambient conditions, whereas high-pressure simulations become increasingly important in pressure perturbation studies, using pressure as an independent thermodynamic variable. Here, we explore the design of non-polarizable force fields tailored to work well in the realm of kilobar pressures - while avoiding complete reparameterization. Our key is to first compute the pressure-induced electronic and structural response of a solute by combining an integral equation approach to include pressure effects on solvent structure with a quantum-chemical treatment of the solute within the embedded cluster reference interaction site model (EC-RISM) framework. Next, the solute's response to compression is taken into account by introducing pressure-dependence into selected parameters of a well-established force field. In our proof-of-principle study, the full machinery is applied to N,N,N-trimethylamine-N-oxide (TMAO) in water being a potent osmolyte that counteracts pressure denaturation. EC-RISM theory is shown to describe well the charge redistribution upon compression of TMAO(aq) to 10 kbar, which is then embodied in force field molecular dynamics by pressure-dependent partial charges. The performance of the high pressure force field is assessed by comparing to experimental and ab initio molecular dynamics data. Beyond its broad usefulness for designing non-polarizable force fields for extreme thermodynamic conditions, a good description of the pressure-response of solutions is highly recommended when constructing and validating polarizable force fields.

  19. Implantable electronics: emerging design issues and an ultra light-weight security solution.

    Science.gov (United States)

    Narasimhan, Seetharam; Wang, Xinmu; Bhunia, Swarup

    2010-01-01

    Implantable systems that monitor biological signals require increasingly complex digital signal processing (DSP) electronics for real-time in-situ analysis and compression of the recorded signals. While it is well-known that such signal processing hardware needs to be implemented under tight area and power constraints, new design requirements emerge with their increasing complexity. Use of nanoscale technology shows tremendous benefits in implementing these advanced circuits due to dramatic improvement in integration density and power dissipation per operation. However, it also brings in new challenges such as reliability and large idle power (due to higher leakage current). Besides, programmability of the device as well as security of the recorded information are rapidly becoming major design considerations of such systems. In this paper, we analyze the emerging issues associated with the design of the DSP unit in an implantable system. Next, we propose a novel ultra light-weight solution to address the information security issue. Unlike the conventional information security approaches like data encryption, which come at large area and power overhead and hence are not amenable for resource-constrained implantable systems, we propose a multilevel key-based scrambling algorithm, which exploits the nature of the biological signal to effectively obfuscate it. Analysis of the proposed algorithm in the context of neural signal processing and its hardware implementation shows that we can achieve high level of security with ∼ 13X lower power and ∼ 5X lower area overhead than conventional cryptographic solutions.

  20. Development of standardized extractive solution from Lippia sidoides by factorial design and their redox active profile

    Directory of Open Access Journals (Sweden)

    Bruno S. Lima

    2015-06-01

    Full Text Available AbstractThe aim of this study was to evaluate the influences of variables of preparation on total flavonoids content from extractive solution of Lippia sidoides Cham., Verbenaceae. Thus a 23 factorial design was used to study the importance of plant proportion, the extraction method and solvent on the extraction of flavonoid. The methodology of determination of chemicals in factorial design was validated according to the parameters required by Brazilian Health Agency. The extraction solution was selected through a full factorial design where the best conditions to achieve the highest content of flavonoids were: 7.5% (w/v of plant with ethanol 50% (v/v as solvent. The polyphenols content was determined by LC method and its relationship with the antioxidant and free radical scavenging activities was evaluated. The free radical scavenging activities and antioxidant potentials were determined for different concentrations using various in vitro models. Our results indicate that extracts exhibited a significant dose-dependent antioxidant effect as evaluated by TRAP/TAR assays. Besides, we observed an antioxidant activity against hydroxyl radicals and nitric oxide, and protection against lipid peroxidation in vitro. Our results suggest that the extract presents significant in vitro antioxidant potential indicating promising perspectives for its use as pharmaceutical/or food additive.

  1. Thermal/mechanical simulation and laboratory fatigue testing of an alternative yttria tetragonal zirconia polycrystal core-veneer all-ceramic layered crown design.

    Science.gov (United States)

    Bonfante, Estevam A; Rafferty, Brian; Zavanelli, Ricardo A; Silva, Nelson R F A; Rekow, Elizabeth D; Thompson, Van P; Coelho, Paulo G

    2010-04-01

    This study evaluated the stress levels at the core layer and the veneer layer of zirconia crowns (comprising an alternative core design vs. a standard core design) under mechanical/thermal simulation, and subjected simulated models to laboratory mouth-motion fatigue. The dimensions of a mandibular first molar were imported into computer-aided design (CAD) software and a tooth preparation was modeled. A crown was designed using the space between the original tooth and the prepared tooth. The alternative core presented an additional lingual shoulder that lowered the veneer bulk of the cusps. Finite element analyses evaluated the residual maximum principal stresses fields at the core and veneer of both designs under loading and when cooled from 900 degrees C to 25 degrees C. Crowns were fabricated and mouth-motion fatigued, generating master Weibull curves and reliability data. Thermal modeling showed low residual stress fields throughout the bulk of the cusps for both groups. Mechanical simulation depicted a shift in stress levels to the core of the alternative design compared with the standard design. Significantly higher reliability was found for the alternative core. Regardless of the alternative configuration, thermal and mechanical computer simulations showed stress in the alternative core design comparable and higher to that of the standard configuration, respectively. Such a mechanical scenario probably led to the higher reliability of the alternative design under fatigue.

  2. Development of Low Global Warming Potential Refrigerant Solutions for Commercial Refrigeration Systems using a Life Cycle Climate Performance Design Tool

    Energy Technology Data Exchange (ETDEWEB)

    Abdelaziz, Omar [ORNL; Fricke, Brian A [ORNL; Vineyard, Edward Allan [ORNL

    2012-01-01

    Commercial refrigeration systems are known to be prone to high leak rates and to consume large amounts of electricity. As such, direct emissions related to refrigerant leakage and indirect emissions resulting from primary energy consumption contribute greatly to their Life Cycle Climate Performance (LCCP). In this paper, an LCCP design tool is used to evaluate the performance of a typical commercial refrigeration system with alternative refrigerants and minor system modifications to provide lower Global Warming Potential (GWP) refrigerant solutions with improved LCCP compared to baseline systems. The LCCP design tool accounts for system performance, ambient temperature, and system load; system performance is evaluated using a validated vapor compression system simulation tool while ambient temperature and system load are devised from a widely used building energy modeling tool (EnergyPlus). The LCCP design tool also accounts for the change in hourly electricity emission rate to yield an accurate prediction of indirect emissions. The analysis shows that conventional commercial refrigeration system life cycle emissions are largely due to direct emissions associated with refrigerant leaks and that system efficiency plays a smaller role in the LCCP. However, as a transition occurs to low GWP refrigerants, the indirect emissions become more relevant. Low GWP refrigerants may not be suitable for drop-in replacements in conventional commercial refrigeration systems; however some mixtures may be introduced as transitional drop-in replacements. These transitional refrigerants have a significantly lower GWP than baseline refrigerants and as such, improved LCCP. The paper concludes with a brief discussion on the tradeoffs between refrigerant GWP, efficiency and capacity.

  3. A Low Cost Design Solution - DSP Based Active Power Factor Corrector for SMPS/ UPS( Single Phase

    Directory of Open Access Journals (Sweden)

    Samia P. Pitchai

    2006-01-01

    Full Text Available As per international agency regulation (IEC 1000-3-2/EN 61000-3-2 and market expectation, it is important to reduce current harmonics in the AC line current drawn by SMPS/ UPS connected to AC Mains as source and also it is desired by the user to deliver maximum power output by achieving unity power factor. To achieve the above objectives in SMPS/ UPS, APFC is required to be implemented as front end power interface between SMPS/UPS and AC Mains source. This study explores low cost design solution - DSP based APFC for Industry involved in manufacturing/supply of SMPS/UPS.

  4. Plant-Scale Concentration Column Designs for SHINE Target Solution Utilizing AG 1 Anion Exchange Resin

    Energy Technology Data Exchange (ETDEWEB)

    Stepinski, Dominique C. [Argonne National Lab. (ANL), Argonne, IL (United States); Vandegrift, G. F. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-30

    Argonne is assisting SHINE Medical Technologies (SHINE) in their efforts to develop SHINE, an accelerator-driven process that will utilize a uranyl-sulfate solution for the production of fission product Mo-99. An integral part of the process is the development of a column for the separation and recovery of Mo-99, followed by a concentration column to reduce the product volume from 15-25 L to <1 L. Argonne has collected data from batch studies and breakthrough column experiments to utilize the VERSE (Versatile Reaction Separation) simulation program (Purdue University) to design plant-scale product recovery and concentration processes.

  5. Service design as the ground for alternative social and economic scenarios

    DEFF Research Database (Denmark)

    Sbordone, Maria Antonietta; Morelli, Nicola

    2017-01-01

    This paper focuses on Service Design as the theoretical and operative framework for activities in very diversified contexts. Within this framework, the paper analyses the design of services and service systems as a form of mediation, integration and diffusion of new operational practices...

  6. The Dutch IOR approach to organizational design : An alternative to business process re-engineering?

    NARCIS (Netherlands)

    van Eijnatten, FM; van der Zwaan, AH

    1998-01-01

    This paper presents the current Dutch sociotechnical design approach to integral organizational renewal in a contextual way. Both its design theory and intervention processes are reviewed and some aggregated empirical evidence is presented. Next, the paper compares the ideas developed in the Dutch a

  7. Selection and development of innovative design alternatives: Ethical, social and uncertainty issues

    NARCIS (Netherlands)

    Jacobs, J.F.

    2015-01-01

    Innovative engineering design shapes the development of novel technologies and is ethically as well as socially relevant, because it affects what kind of possibilities and consequences will arise. A major challenge in engineering design work on innovative technologies is the multitude of uncertainti

  8. The Dutch IOR approach to organizational design : An alternative to business process re-engineering?

    NARCIS (Netherlands)

    van Eijnatten, FM; van der Zwaan, AH

    This paper presents the current Dutch sociotechnical design approach to integral organizational renewal in a contextual way. Both its design theory and intervention processes are reviewed and some aggregated empirical evidence is presented. Next, the paper compares the ideas developed in the Dutch

  9. Human-centred methods in the design of an e-health solution for patients undergoing weight loss treatment

    DEFF Research Database (Denmark)

    Das, Anita; Svanæs, Dag

    2013-01-01

    Background and objective Patients undergoing weight loss treatment require follow-up as part of the treatment process. E-health solutions may be used for this purpose. We have used an iterative design approach to develop a patient-centred e-health solution for patients undergoing weight loss...... in the design process. Our findings imply that involving stakeholders separately during specific human-centred activities is important in order to capture subtle, but critical aspects of the users’ requirements. Conclusion Applying human-centred methods in the design of e-health solutions requires...

  10. Distribution Network Design for Fixed Lifetime Perishable Products: A Model and Solution Approach

    Directory of Open Access Journals (Sweden)

    Z. Firoozi

    2013-01-01

    Full Text Available Nowadays, many distribution networks deal with the distribution and storage of perishable products. However, distribution network design models are largely based on assumptions that do not consider time limitations for the storage of products within the network. This study develops a model for the design of a distribution network that considers the short lifetime of perishable products. The model simultaneously determines the network configuration and inventory control decisions of the network. Moreover, as the lifetime is strictly dependent on the storage conditions, the model develops a trade-off between enhancing storage conditions (higher inventory cost to obtain a longer lifetime and selecting those storage conditions that lead to shorter lifetimes (less inventory cost. To solve the model, an efficient Lagrangian relaxation heuristic algorithm is developed. The model and algorithm are validated by sensitivity analysis on some key parameters. Results show that the algorithm finds optimal or near optimal solutions even for large-size cases.

  11. A computer package for the design and eigenproblem solution of damped linear multidegree of freedom systems

    Science.gov (United States)

    Ahmadian, M.; Inman, D. J.

    1982-01-01

    Systems described by the matrix differental equation are considered. An interactive design routine is presented for positive definite mass, damping, and stiffness matrices. Designing is accomplished by adjusting the mass, damping, and stiffness matrices to obtain a desired oscillation behavior. The algorithm also features interactively modifying the physical structure of the system, obtaining the matrix structure and a number of other system properties. In case of a general system, where the M, C, and K matrices lack any special properties, a routine for the eigenproblem solution of the system is developed. The latent roots are obtained by computing the characteristic polynomial of the system and solving for its roots. The above routines are prepared in FORTRAN IV and prove to be usable for the machines with low core memory.

  12. Challenges and design solutions of the liquid hydrogen circuit at the European Spallation Source

    Science.gov (United States)

    Gallimore, S.; Nilsson, P.; Sabbagh, P.; Takibayev, A.; Weisend, J. G., II; Beßler, Y.; Klaus, M.

    2014-01-01

    The European Spallation Source (ESS), Lund, Sweden will be a 5MW long-pulse neutron spallation research facility and will enable new opportunities for researchers in the fields of life sciences, energy, environmental technology, cultural heritage and fundamental physics. Neutrons are produced by accelerating a high-energy proton beam into a rotating helium-cooled tungsten target. These neutrons pass through moderators to reduce their energy to an appropriate range (< 5 meV for cold neutrons); two of which will use liquid hydrogen at 17 K as the moderating and cooling medium. There are several technical challenges to overcome in the design of a robust system that will operate under such conditions, not least the 20 kW of deposited heat. These challenges and the associated design solutions will be detailed in this paper.

  13. Alternate current magnetic property characterization of nonstoichiometric zinc ferrite nanocrystals for inductor fabrication via a solution based process

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Hongseok [Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Kim, Jungkwun; Allen, Mark G. [Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Paik, Taejong [Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); School of Integrative Engineering, Chung-Ang University, Seoul 06974 (Korea, Republic of); Meng, Lingyao [Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Jo, Pil Sung [Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Complex Assemblies of Soft Matter, CNRS-SOLVAY-PENN UMI 3254, Bristol, Pennsylvania 19007-3624 (United States); Kikkawa, James M. [Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Kagan, Cherie R. [Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Murray, Christopher B., E-mail: cbmurray@sas.upenn.edu [Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)

    2016-03-21

    We investigate the ac magnetic behavior of solution processable, non-stoichiometric zinc ferrite nanocrystals with a series of sizes and zinc concentrations. Nearly monodisperse Zn{sub x}Fe{sub 3−x}O{sub 4} nanocrystals (x = 0–0.25) with an average size ranging from 7.4 nm to 13.8 nm are synthesized by using a solvothermal method. All the nanocrystals are in a superparamagnetic state at 300 K, which is confirmed by Superconductive Quantum Interference Device magnetometry. Due to the doping of non-magnetic Zn{sup 2+} into A site of ferrite, the saturation magnetization of nanocrystals increases as the size and Zn concentration increases. The ac magnetic permeability measurements at radio frequencies reveal that the real part of the magnetic permeability of similarly sized ferrite nanocrystals can be enhanced by almost twofold as the Zn{sup 2+} doping level increases from 0 to 0.25. The integration of 12.3 nm Zn{sub 0.25}Fe{sub 2.75}O{sub 4} nanocrystals into a toroidal inductor and a solenoid inductor prepared via a simple solution cast process yields a higher quality factors than air core inductors with the same geometries up to 5 MHz and 9 MHz, respectively, which is in the regime of the switching frequencies for the advanced integrated power converters.

  14. Impact of Rate Design Alternatives on Residential Solar Customer Bills. Increased Fixed Charges, Minimum Bills and Demand-based Rates

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Davidson, Carolyn [National Renewable Energy Lab. (NREL), Golden, CO (United States); McLaren, Joyce [National Renewable Energy Lab. (NREL), Golden, CO (United States); Miller, John [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    With rapid growth in energy efficiency and distributed generation, electric utilities are anticipating stagnant or decreasing electricity sales, particularly in the residential sector. Utilities are increasingly considering alternative rates structures that are designed to recover fixed costs from residential solar photovoltaic (PV) customers with low net electricity consumption. Proposed structures have included fixed charge increases, minimum bills, and increasingly, demand rates - for net metered customers and all customers. This study examines the electricity bill implications of various residential rate alternatives for multiple locations within the United States. For the locations analyzed, the results suggest that residential PV customers offset, on average, between 60% and 99% of their annual load. However, roughly 65% of a typical customer's electricity demand is non-coincidental with PV generation, so the typical PV customer is generally highly reliant on the grid for pooling services.

  15. Evaluation of occupational health interventions using a randomized controlled trial: challenges and alternative research designs

    NARCIS (Netherlands)

    Schelvis, R.M; Oude Hengel, K.M.; Burdorf, A.; Blatter, B.M.; Strijk, J.E.; Beek, A.J. van

    2015-01-01

    Occupational health researchers regularly conduct evaluative intervention research for which a randomized controlled trial (RCT) may not be the most appropriate design (eg, effects of policy measures, organizational interventions on work schedules). This article demonstrates the appropriateness of a

  16. GREENER CHEMICAL PROCESS DESIGN ALTERNATIVES ARE REVEALED USING THE WASTE REDUCTION DECISION SUPPORT SYSTEM (WAR DSS)

    Science.gov (United States)

    The Waste Reduction Decision Support System (WAR DSS) is a Java-based software product providing comprehensive modeling of potential adverse environmental impacts (PEI) predicted to result from newly designed or redesigned chemical manufacturing processes. The purpose of this so...

  17. Capture chromatography for Mo-99 recovery from uranyl sulfate solutions: minimum-column-volume design method.

    Science.gov (United States)

    Ling, Lei; Chung, Pei-Lun; Youker, Amanda; Stepinski, Dominique C; Vandegrift, George F; Wang, Nien-Hwa Linda

    2013-09-27

    Molybdenum-99 (Mo-99), generated from the fission of Uranium-235 (U-235), is the radioactive parent of the most widely used medical isotope, technetium-99m (Tc-99m). An efficient, robust, low-pressure process is developed for recovering Mo-99 from uranyl sulfate solutions. The minimum column volume and the maximum column length for required yield, pressure limit, and loading time are determined using a new graphical method. The method is based on dimensionless groups and intrinsic adsorption and diffusion parameters, which are estimated using a small number of experiments and simulations. The design is tested with bench-scale experiments with titania columns. The results show a high capture yield and a high stripping yield (95±5%). The design can be adapted to changes in design constraints or the variations in feed concentration, feed volume, or material properties. The graph shows clearly how the column utilization is affected by the required yield, loading time, and pressure limit. The cost effectiveness of various sorbent candidates can be evaluated based on the intrinsic parameters. This method can be used more generally for designing other capture chromatography processes. Published by Elsevier B.V.

  18. Testing the biocompatibility of a glutathione-containing intra-ocular irrigation solution by using an isolated perfused bovine retina organ culture model - an alternative to animal testing.

    Science.gov (United States)

    Januschowski, Kai; Zhour, Ahmad; Lee, Albert; Maddani, Ramin; Mueller, Sebastien; Spitzer, Martin S; Schnichels, Sven; Schultheiss, Maximilian; Doycheva, Deshka; Bartz-Schmidt, Karl-Ulrich; Szurman, Peter

    2012-03-01

    The effects of a glutathione-containing intra-ocular irrigation solution, BSS Plus©, on retinal function and on the survival of ganglion cells in whole-mount retinal explants were studied. Evidence is provided that the perfused ex vivo bovine retina can serve as an alternative to in vivo animal testing. Isolated bovine retinas were prepared and perfused with an oxygen-saturated standard irrigation solution, and an electroretinogram was recorded to assess retinal function. After stable b-waves were detected, the isolated retinas were perfused with BSS Plus for 45 minutes. To investigate the effects of BSS Plus on photoreceptor function, 1mM aspartate was added to the irrigation solution in order to obtain a-waves, and the ERG trace was monitored for 75 minutes. For histological analysis, isolated whole retinal mounts were stored for 24 hours at 4°C, in the dark. The percentages of cell death in the retinal ganglion cell layer and in the outer and inner nuclear layers were estimated by using an ethidium homodimer-1 stain and the TUNEL assay. General swelling of the retina was examined with high-resolution optical coherence tomography. During perfusion with BSS Plus, no significant changes in a-wave and b-wave amplitudes were recorded. Retinas stored for 24 hours in BSS Plus showed a statistically significant smaller percentage (52.6%, standard deviation [SD] = 16.1%) of cell death in the retinal ganglion cell layer compared to the control group (69.6%, SD = 3.9, p = 0.0031). BSS Plus did not seem to affect short-term retinal function, and had a beneficial effect on the survival of retinal ganglion cells. This method for analysing the isolated perfused retina represents a valuable alternative for testing substances for their retinal biocompatibility and toxicity. 2012 FRAME.

  19. PrimerSeq:Design and Visualization of RT-PCR Primers for Alternative Splicing Using RNA-seq Data

    Institute of Scientific and Technical Information of China (English)

    Collin Tokheim; Juw Won Park; Yi Xing

    2014-01-01

    The vast majority of multi-exon genes in higher eukaryotes are alternatively spliced and changes in alternative splicing (AS) can impact gene function or cause disease. High-throughput RNA sequencing (RNA-seq) has become a powerful technology for transcriptome-wide analysis of AS, but RT-PCR still remains the gold-standard approach for quantifying and validating exon splicing levels. We have developed PrimerSeq, a user-friendly software for systematic design and visualization of RT-PCR primers using RNA-seq data. PrimerSeq incorporates user-provided tran-scriptome profiles (i.e., RNA-seq data) in the design process, and is particularly useful for large-scale quantitative analysis of AS events discovered from RNA-seq experiments. PrimerSeq features a graphical user interface (GUI) that displays the RNA-seq data juxtaposed with the expected RT-PCR results. To enable primer design and visualization on user-provided RNA-seq data and transcript annotations, we have developed PrimerSeq as a stand-alone software that runs on local computers. PrimerSeq is freely available for Windows and Mac OS X along with source code at http://primerseq.sourceforge.net/. With the growing popularity of RNA-seq for transcriptome stud-ies, we expect PrimerSeq to help bridge the gap between high-throughput RNA-seq discovery of AS events and molecular analysis of candidate events by RT-PCR.

  20. The Unsuccessful Poverty Reduction Strategies in Indonesia and the Alternatives Solutions (The Study on BLT and Jamkesmas

    Directory of Open Access Journals (Sweden)

    Dewi Iriani

    2014-08-01

    Full Text Available Indonesia as the 16th largest economy in the world, the 4th in Asia-after China, Japan and India as well as Southeast Asia’s largest-has the potential to be the seventh biggest by 2030, due to the increasing economic. Indonesia also has many potential natural resources that can be utilized to support development in order to increase the nation welfare. However, the number of poor people still has not been significantly reduced, reaching 28.07 million or 11.37% of the total population in 2013. The Government has tried to reduce poverty with some programs such as BLT (Bantuan Langsung Tunai/Direct Cash Assistance and Jamkesmas (Jaminan Kesehatan Masyarakat/ Community Health Protection Scheme. However, the programs are considered not effective and do not make poor people become financially independent. Ironically, in inadequate evaluation, the Government continues to runs the programs. By using a qualitative approach, researchers will provide policy alternatives that can be implemented by Government.

  1. Examination of alternate codon bias solutions for expression and purification of recombinant mechano-growth factor in Escherichia coli.

    Science.gov (United States)

    Feng, Jianguo; Wan, Rongxue; Yi, Qian; He, Ling; Yang, Li; Tang, Liling

    2015-01-01

    Mechano-growth factor (MGF), an alternative splicing variant of insulin-like growth factor-1 (IGF-1) gene, promotes cell proliferation and inhibits cell differentiation. It also plays an important role in tumor development. It is important to optimize the production process and achieve MGF protein because there is no commercial MGF protein available. In this study, the human MGF gene is cloned into pGEX-4T-1 and the recombinant human MGF (rhMGF) protein could be expressed in Rosetta (DE3) by isopropyl β-D-1-thiogalactopyranoside induction but not in BL21 (DE3). Mutation from rare codons to Escherichia coli preferred ones is performed. We obtain MGF(Mut54-56) and MGF(Mut-total) fragments through site-directed mutagenesis and overlapping PCR. Both pGEX-4T-1/MGF(Mut54-56)- and pGEX-4T-1/MGF(Mut-total)-transformed BL21 (DE3) can be induced to express rhMGF protein. To optimize the production technology, expression and purification of rhMGF are analyzed and compared in Rosetta (DE3) and BL21 (DE3). Results indicate that rhMGF expression in BL21 (DE3) is significantly higher than that in Rosetta (DE3). The protein yield of pGEX-4T-1/MGF(Mut-total) in BL21 (DE3) is higher than that of pGEX-4T-1/MGF(Mut54-56). We test the biological activity of MGF protein purified by affinity chromatography in C2C12 cell line and find that rhMGF promotes cell proliferation significantly. In conclusion, we establish a method to produce rhMGF economically with high biological activity in BL21 (DE3).

  2. Vehicle perceptibilty : reflectorized registration plates and alternative means : function, design and application.

    NARCIS (Netherlands)

    Griep, D.J. Thoenes, E. Schreuder, D.A. & Kranenburg, A.

    1970-01-01

    In November 1967 the Minister of Transport and Waterways in the Netherlands asked the Institute for Road Safety Research SWOV to examine the advisable design of reflectorized registration plates from the aspect of perceptibility. Allowance had to be made for the identification of motor vehicles.

  3. 49 CFR 192.112 - Additional design requirements for steel pipe using alternative maximum allowable operating...

    Science.gov (United States)

    2010-10-01

    ...) of this section, additional design features, such as mechanical or composite crack arrestors and/or... surface of the plate/coil or pipe to identify imperfections that impair serviceability such as laminations... must be a hardness test, using Vickers (Hv10) hardness test method or equivalent test method, to...

  4. Adopting the alternate reality game approach in the design of the Singa environment

    CSIR Research Space (South Africa)

    Dlodlo, N

    2010-01-01

    Full Text Available Playing games, especially electronic games, is a popular free-time activity among children and adolescents and these games seem to have a prominent role in the culture of young people. It is with this in mind that the SINGA environment was designed...

  5. Applied acoustics concepts, absorbers, and silencers for acoustical comfort and noise control alternative solutions, innovative tools, practical examples

    CERN Document Server

    Fuchs, Helmut V

    2013-01-01

    The author gives a comprehensive overview of materials and components for noise control and acoustical comfort. Sound absorbers must meet acoustical and architectural requirements, which fibrous or porous material alone can meet. Basics and applications are demonstrated, with representative examples for spatial acoustics, free-field test facilities and canal linings. Acoustic engineers and construction professionals will find some new basic concepts and tools for developments in order to improve acoustical comfort. Interference absorbers, active resonators and micro-perforated absorbers of different materials and designs complete the list of applications.

  6. Optimization of the design and preparation of nanoscale phospholipid bilayers for its application to solution NMR.

    Science.gov (United States)

    Puthenveetil, Robbins; Vinogradova, Olga

    2013-07-01

    Despite arduous efforts and recent technological developments structural investigation of integral membrane proteins remains a challenge. The primary deterrents include difficulties with their expression, low inherent solubility, and problems associated with existing membrane mimicking systems. A relatively new class of membrane mimetics, nanodiscs, is emerging as a promising alternative. Although nanodiscs have been proven successful for several biophysical applications, they yet remain to become the system of preferred choice for structure determination. We have hereby made nanodiscs more suitable for solution NMR applications by reducing the diameter of the self-assembly complex to its potential limit. We achieved a noticeable improvement in the quality of NMR spectra obtained for the transmembrane and cytoplasmic domains of integrin αIIb incorporated into these smaller discs rendering them susceptible for a thorough structural investigation. In addition, we also present an on-column method for a rapid, efficient, single-step preparation of protein incorporated nanodiscs at high concentrations. These discs have been fully characterized by transmission electron microscopy, dynamic light scattering, and differential scanning calorimetry.

  7. AN ALTERNATIVE APPROACH TO DESIGN AND ANALYSIS OF BROADBAND BEAMSPACE ADAPTIVE ARRAYS

    Directory of Open Access Journals (Sweden)

    A. S. SRINIVASA RAO

    2011-09-01

    Full Text Available The beamwidth of a linear array depends on number of elements in the array and frequency of the input signal. At present designing of wideband antennas and beamformers became important, in the fields of microphone arrays intended for teleconferencing, in transmitting or receiving spread spectrum signals, crip signals etc. A beamspace adaptive planar array for broadband beamforming is proposed based on the filter – and - sum beamforming technique. A detailed design method was provided for both the linear arrays and the adaptivearrays and simulation results are provided for the proposed method. Our proposed method is used to demonstrate that the beam-space adaptive array can suppress interference signals having a wide fractional bandwidth and that the array has fast convergence.

  8. The Effects of Envelope Design Alternatives on the Energy Consumption of Residential Houses in Indonesia

    Directory of Open Access Journals (Sweden)

    Andre Feliks Setiawan

    2015-04-01

    Full Text Available As an emerging country and one of the most populous countries in the world, Indonesia requires a sufficient energy supply to ensure the nation’s continued development. In response to this increasing energy demand, various studies have proposed energy-saving measures; building envelope design is considered to be a typical energy-saving technique. A significant goal in achieving greener buildings is learning how to reduce a building’s energy consumption by applying an efficient energy-saving design. This study used the eQUEST software to investigate how different types of roof construction, glazing and sun-shading techniques affect the energy consumption of residential structures in Indonesia in common scenarios. The results indicate that window shading has the most significant impact on a building’s overall energy consumption, followed by the use of an appropriate glazing, whereas the roof type produced smaller energy efficiency benefits.

  9. System design optimization for a Mars-roving vehicle and perturbed-optimal solutions in nonlinear programming

    Science.gov (United States)

    Pavarini, C.

    1974-01-01

    Work in two somewhat distinct areas is presented. First, the optimal system design problem for a Mars-roving vehicle is attacked by creating static system models and a system evaluation function and optimizing via nonlinear programming techniques. The second area concerns the problem of perturbed-optimal solutions. Given an initial perturbation in an element of the solution to a nonlinear programming problem, a linear method is determined to approximate the optimal readjustments of the other elements of the solution. Then, the sensitivity of the Mars rover designs is described by application of this method.

  10. A simple and efficient alternative to implementing systematic random sampling in stereological designs without a motorized microscope stage.

    Science.gov (United States)

    Melvin, Neal R; Poda, Daniel; Sutherland, Robert J

    2007-10-01

    When properly applied, stereology is a very robust and efficient method to quantify a variety of parameters from biological material. A common sampling strategy in stereology is systematic random sampling, which involves choosing a random sampling [corrected] start point outside the structure of interest, and sampling relevant objects at [corrected] sites that are placed at pre-determined, equidistant intervals. This has proven to be a very efficient sampling strategy, and is used widely in stereological designs. At the microscopic level, this is most often achieved through the use of a motorized stage that facilitates the systematic random stepping across the structure of interest. Here, we report a simple, precise and cost-effective software-based alternative to accomplishing systematic random sampling under the microscope. We believe that this approach will facilitate the use of stereological designs that employ systematic random sampling in laboratories that lack the resources to acquire costly, fully automated systems.

  11. Design of an alternating phase focusing Interdigital H-mode Drift-Tube-Linac with low injection energy

    Science.gov (United States)

    Zhao, L.; Pang, J.; He, X.; Ying, Z.; Shi, J.

    2016-01-01

    An Inter-digital H-mode (IH) Drift Tube Linac (DTL) was designed to accelerate a proton beam in the low energy region with high RF efficiency and high gradient. The IH DTL is 1.078 m long and operates at 200 MHz. Protons could be accelerated from 0.04 MeV to 2.4 MeV (the β range is from 0.0092 to 0.0714). The method of alternating phase focusing (APF) was applied for beam focusing. The simulation results show that the transmission is 38% and the longitudinal acceptance is approximately 140°. The shunt impedance of the entire cavity is 365 MΩ/m. Adjustments of the electric-field were performed, and the beam dynamics design was described. The beam loss and voltage sensitivity were calculated.

  12. The design and simulation investigation of a linear alternator dynamometer coupled to a free-piston Stirling engine

    Science.gov (United States)

    Goldberg, L. F.; Lee, K. P.

    1985-12-01

    The design of a linear alternator dynamometer and its control system intended for testing free-piston Stirling engines is described. The characteristics and performance of the dynamometer are demonstrated by a computer simulation in which the dynamometer is coupled to a Sunpower RE1000 free-piston engine. The simulation embodies algorithms which combine the gas dynamics of the engine working spaces with the dynamic behavior of the displacer and the piston/armature assembly. Over a variety of different loading conditions including inertial, gravitational and thermodynamic loads as well as linear, quadratic and Coulombic damping, the dynamometer exhibited a force error of 0.5 percent or 0.006 N at worst. The simulation investigation demonstrates that the dynamometer and its control system possess the necessary characteristics for it to be a practically useful loading device for testing and designing free-piston Stirling engines.

  13. Alternative approaches to fusion. [reactor design and reactor physics for Tokamak fusion reactors

    Science.gov (United States)

    Roth, R. J.

    1976-01-01

    The limitations of the Tokamak fusion reactor concept are discussed and various other fusion reactor concepts are considered that employ the containment of thermonuclear plasmas by magnetic fields (i.e., stellarators). Progress made in the containment of plasmas in toroidal devices is reported. Reactor design concepts are illustrated. The possibility of using fusion reactors as a power source in interplanetary space travel and electric power plants is briefly examined.

  14. Technology Solutions Case Study: Calculating Design Heating Loads for Superinsulated Buildings

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-08-01

    Designing a superinsulated home has many benefits including improved comfort, reduced exterior noise penetration, lower energy bills, and the ability to withstand power and fuel outages under much more comfortable conditions than a typical home. Extremely low heating and cooling loads equate to much smaller HVAC equipment than conventionally required. Sizing the mechanical system to these much lower loads reduces first costs and the size of the distribution system needed. While these homes aren't necessarily constructed with excessive mass in the form of concrete floors and walls, the amount of insulation and the increase in the thickness of the building envelope can lead to a mass effect, resulting in the structures ability to store much more heat than a code built home. This results in a very low thermal inertia making the building much less sensitive to drastic temperature swings thereby decreasing the peak heating load demand. Alternative methods that take this inertia into account along with solar and internal gains result in smaller more appropriate design loads than those calculated using Manual J version 8. During the winter of 2013/2014, the Consortium for Advanced Residential Buildings team monitored the energy use of three homes in climate zone 6 in an attempt to evaluate the accuracy of two different mechanical system sizing methods for low load homes. Based on the results, it is recommended that internal and solar gains be included and some credit for thermal inertia be used in sizing calculations for superinsulated homes.

  15. Life cycle assessment of a parabolic trough concentrating solar power plant and the impacts of key design alternatives.

    Science.gov (United States)

    Burkhardt, John J; Heath, Garvin A; Turchi, Craig S

    2011-03-15

    Climate change and water scarcity are important issues for today's power sector. To inform capacity expansion decisions, hybrid life cycle assessment is used to evaluate a reference design of a parabolic trough concentrating solar power (CSP) facility located in Daggett, CA, along four sustainability metrics: life cycle (LC) greenhouse gas (GHG) emissions, water consumption, cumulative energy demand (CED), and energy payback time (EPBT). This wet-cooled, 103 MW plant utilizes mined nitrates salts in its two-tank, thermal energy storage (TES) system. Design alternatives of dry-cooling, a thermocline TES, and synthetically derived nitrate salt are evaluated. During its LC, the reference CSP plant is estimated to emit 26 g of CO(2eq) per kWh, consume 4.7 L/kWh of water, and demand 0.40 MJ(eq)/kWh of energy, resulting in an EPBT of approximately 1 year. The dry-cooled alternative is estimated to reduce LC water consumption by 77% but increase LC GHG emissions and CED by 8%. Synthetic nitrate salts may increase LC GHG emissions by 52% compared to mined. Switching from two-tank to thermocline TES configuration reduces LC GHG emissions, most significantly for plants using synthetically derived nitrate salts. CSP can significantly reduce GHG emissions compared to fossil-fueled generation; however, dry-cooling may be required in many locations to minimize water consumption.

  16. Life Cycle Assessment of a Parabolic Trough Concentrating Solar Power Plant and Impacts of Key Design Alternatives: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Heath, G. A.; Burkhardt, J. J.; Turchi, C. S.

    2011-09-01

    Climate change and water scarcity are important issues for today's power sector. To inform capacity expansion decisions, hybrid life cycle assessment is used to evaluate a reference design of a parabolic trough concentrating solar power (CSP) facility located in Daggett, California, along four sustainability metrics: life cycle greenhouse gas (GHG) emissions, water consumption, cumulative energy demand (CED), and energy payback time (EPBT). This wet-cooled, 103 MW plant utilizes mined nitrate salts in its two-tank, thermal energy storage (TES) system. Design alternatives of dry-cooling, a thermocline TES, and synthetically-derived nitrate salt are evaluated. During its life cycle, the reference CSP plant is estimated to emit 26 g CO2eq per kWh, consume 4.7 L/kWh of water, and demand 0.40 MJeq/kWh of energy, resulting in an EPBT of approximately 1 year. The dry-cooled alternative is estimated to reduce life cycle water consumption by 77% but increase life cycle GHG emissions and CED by 8%. Synthetic nitrate salts may increase life cycle GHG emissions by 52% compared to mined. Switching from two-tank to thermocline TES configuration reduces life cycle GHG emissions, most significantly for plants using synthetically-derived nitrate salts. CSP can significantly reduce GHG emissions compared to fossil-fueled generation; however, dry-cooling may be required in many locations to minimize water consumption.

  17. Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.

    Science.gov (United States)

    Calhoun, Jennifer R; Liu, Weixia; Spiegel, Katrin; Dal Peraro, Matteo; Klein, Michael L; Valentine, Kathleen G; Wand, A Joshua; DeGrado, William F

    2008-02-01

    We report the solution NMR structure of a designed dimetal-binding protein, di-Zn(II) DFsc, along with a secondary refinement step employing molecular dynamics techniques. Calculation of the initial NMR structural ensemble by standard methods led to distortions in the metal-ligand geometries at the active site. Unrestrained molecular dynamics using a nonbonded force field for the metal shell, followed by quantum mechanical/molecular mechanical dynamics of DFsc, were used to relax local frustrations at the dimetal site that were apparent in the initial NMR structure and provide a more realistic description of the structure. The MD model is consistent with NMR restraints, and in good agreement with the structural and functional properties expected for DF proteins. This work demonstrates that NMR structures of metalloproteins can be further refined using classical and first-principles molecular dynamics methods in the presence of explicit solvent to provide otherwise unavailable insight into the geometry of the metal center.

  18. Alternative Donor--Acceptor Stacks from Crown Ethers and Naphthalene Diimide Derivatives: Rapid, Selective Formation from Solution and Solid State Grinding

    Energy Technology Data Exchange (ETDEWEB)

    Advanced Light Source; Liu, Yi; Klivansky, Liana; Cao, Dennis; Snauko, Marian; Teat, Simon J.; Struppe, Jochem O.; Koshkakaryan, Gayane

    2009-01-22

    Self assembling {pi}-conjugated molecules into ordered structures are of increasing interest in the field of organic electronics. One particular example is charge transfer complexes containing columnar alternative donor-acceptor (ADA) stacks, where neutral and ionic ground states can be readily tuned to modulate electrical, optical, and ferroelectrical properties. Aromatic-aromatic and charge transfer interactions have been the leading driving forces in assisting the self-assembly of ADA stacks. Various folding structures containing ADA stacks were assembled in solution with the aid of solvophobic or ion-binding interactions. Meanwhile, examples of solid ADA stacks, which are more appealing for practical use in devices, were obtained from cocrystalization of binary components or mesophase assembly of liquid crystals in bulk blends. Regardless of these examples, faster and more controllable approaches towards precise supramolecular order in the solid state are still highly desirable.

  19. Testing alternative designs for a roadside animal detection system using a driving simulator

    Directory of Open Access Journals (Sweden)

    Molly K. Grace

    2015-07-01

    Full Text Available Objectives: A Roadside Animal Detection System (RADS was installed in January 2012 along Highway 41 through Big Cypress National Preserve in Florida, USA in an attempt to reduce wildlife-vehicle collisions. The system uses flashing warning signs to alert drivers when a large animal is near the road. However, we suspected that the RADS warning signs could be ignored by drivers because they resemble other conventional signs. We hypothesized that word-based warning signs (current design are less effective than picture-based signs at catching drivers’ attention. Methods: We used a driving simulator to test (1 the effects of the RADS on collision rate, driver speed, and latency to brake; and (2 whether the RADS would be more effective if warning signs were picture-based. Participants were randomly assigned to one of three treatments: no warning (control, word-based RADS signs (current design, and picture-based RADS signs (proposed design. During the simulations, a deer entered the road in front of the driver, and we recorded whether drivers “crashed” or not. Results: Both the picture-based and word-based RADS signs resulted in significantly lower crash probabilities. The picture-based RADS signs performed better than the word-based signs in reducing speed and latency to brake, although the effect varied between twilight and night. However, the word-based RADS signs still did produce significant reductions in speed and braking latency. Conclusions: We conclude that the word-based RADS in Big Cypress should help prevent dangerous wildlife-vehicle collisions, but that redesigning the warning signs to be picture-based could yield even greater benefits.

  20. COMPARING PUMA ROBOT ARM WITH THE HUMAN ARM MOVEMENTS; AN ALTERNATIVE ROBOTIC ARM SHOULDER DESIGN

    OpenAIRE

    Mustafa BOZDEMİR; ADIGÜZEL, Esat

    1999-01-01

    Using the robotic arms instead of human power becomes increasingly widespread nowadays. Widening of the robotic arms usage field is parallel to improvement of movement capability of it. In this study PUMA Robotic Arm System that is a developed system of the robotic arms was compared with a human arm due to movement. A new joint was added to PUMA Robotic Arm System to have the movements similar to the human shoulder joint. Thus, a shoulder was designed that can make movements through the sides...

  1. Cell and stack design alternatives. First quarterly report, August 1, 1978-October 31, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Hoover, D.Q.

    1979-01-01

    An apartment house in Albany, New York with HUD minimum insulation was selected as the application to be used in evaluating various system configurations of on-site fuel cell total energy systems. Methods for calculating the static and dynamic thermal loads for a simulated season were developed. Computer models of some major subsystems are now being developed. Finite element models of the electrochemistry, thermodynamics and heat transfer relationships for fuel cells were developed and have been used to calculate current density and temperature distributions for sets of large cells and cooling plates. The results obtained led to several innovative ideas for advanced stack designs. A single lump model of a fuel cell stack was developed for use in the systems study. The available information on methane conditioning was collected and reviewed and a plan for attaining the missing design data has been developed. Simple models of reformer and water-gas shift reactors were developed for use in the systems study. The lines of communication among technical tasks were established, required documentation of plans and progress was prepared and delivered and the monthly review meetings were held as planned.

  2. Thermal Dissipation Modelling and Design of ITER PF Converter Alternating Current Busbar

    Science.gov (United States)

    Guo, Bin; Song, Zhiquan; Fu, Peng; Jiang, Li; Li, Jinchao; Wang, Min; Dong, Lin

    2016-10-01

    Because the larger metallic surrounds are heated by the eddy current, which is generated by the AC current flowing through the AC busbar in the International Thermonuclear Experimental Reactor (ITER) poloidal field (PF) converter system, shielding of the AC busbar is required to decrease the temperature rise of the surrounds to satisfy the design requirement. Three special types of AC busbar with natural cooling, air cooling and water cooling busbar structure have been proposed and investigated in this paper. For each cooling scheme, a 3D finite model based on the proposed structure has been developed to perform the electromagnetic and thermal analysis to predict their operation behavior. Comparing the analysis results of the three different cooling patterns, water cooling has more advantages than the other patterns and it is selected to be the thermal dissipation pattern for the AC busbar of ITER PF converter unit. The approach to qualify the suitable cooling scheme in this paper can be provided as a reference on the thermal dissipation design of AC busbar in the converter system. supported by National Natural Science Foundation of China (No. 51407179)

  3. Pentameric models as alternative molecular targets for the design of new antiaggregant agents.

    Science.gov (United States)

    Barrera Guisasola, Exequiel E; Gutierrez, Lucas J; Andujar, Sebastián A; Angelina, Emilio; Rodríguez, Ana M; Enriz, Ricardo D

    2016-01-01

    The structure-based drug design has been an extremely useful technique used for searching and developing of new therapeutic agents in various biological systems. In the case of AD, this approach has been difficult to implement. Among other several causes, the main problem might be the lack of a specific stable and reliable molecular target. In this paper the results obtained using a pentameric amyloid beta (Aβ) model as a molecular target are discussed. Our MD simulations have shown that this system is relatively structured and stable, displaying a lightly conformational flexibility during 2.0 μs of simulation time. This study allowed us to distinguish characteristic structural features in specific regions of the pentamer which should be taken into account when choosing this model as a molecular target. This represents a clear advantage compared to the monomer or dimer models which are highly flexible structures with large numbers of possible conformers. Using this pentameric model we performed two types of studies usually carried out on a molecular target: a virtual screening and the design on structural basis of new mimetic peptides with antiaggregant properties. Our results indicate that this pentameric model might be a good molecular target for these particular studies of molecular modeling. Details about the predictive power of our virtual screening as well as about the molecular interactions that stabilize the mimetic peptide-pentamer Aβ complexes are discussed in this paper.

  4. A MINE alternative to D-optimal designs for the linear model.

    Directory of Open Access Journals (Sweden)

    Amanda M Bouffier

    Full Text Available Doing large-scale genomics experiments can be expensive, and so experimenters want to get the most information out of each experiment. To this end the Maximally Informative Next Experiment (MINE criterion for experimental design was developed. Here we explore this idea in a simplified context, the linear model. Four variations of the MINE method for the linear model were created: MINE-like, MINE, MINE with random orthonormal basis, and MINE with random rotation. Each method varies in how it maximizes the MINE criterion. Theorem 1 establishes sufficient conditions for the maximization of the MINE criterion under the linear model. Theorem 2 establishes when the MINE criterion is equivalent to the classic design criterion of D-optimality. By simulation under the linear model, we establish that the MINE with random orthonormal basis and MINE with random rotation are faster to discover the true linear relation with p regression coefficients and n observations when p>>n. We also establish in simulations with n<100, p=1000, σ=0.01 and 1000 replicates that these two variations of MINE also display a lower false positive rate than the MINE-like method and additionally, for a majority of the experiments, for the MINE method.

  5. Alternative solutions to the concrete fully-slatted floor for the housing of finishing beef cattle: effects on growth performance, health of the locomotor system and behaviour.

    Science.gov (United States)

    Cozzi, G; Tessitore, E; Contiero, B; Ricci, R; Gottardo, F; Brscic, M

    2013-08-01

    The aim of this study was to assess the effect of two potential alternative solutions to the concrete fully-slatted floor (FS), namely, a perforated floor (PF) and a perforated floor coated with a rubber mattress (RM), on growth, locomotor system health, and behaviour of intensively finished young bulls. Forty-eight male beef-crosses (Charolais × Aubrac) were allotted to six pens of eight animals (two pens/floor type) for a finishing period of 175 ± 7 days. Growth was recorded and two health checks and two 8-h behavioural observations were carried out by trained assessors 1 month after the beginning of the trial (Initial) and 2 weeks before slaughter (Final). Feed intake was not affected by floor type, but average daily gain of RM bulls was higher than that of FS (1.37 vs. 1.19 kg, P=0.01), with PF being intermediate (1.27 kg). Behavioural observations showed that FS bulls had a higher number of slipping events (6.5) than PF (2.1; P=0.01) and RM bulls (0.9; Pfloor proved to be a good alternative to FS but it increased the likelihood of overgrown claws due to insufficient hoof wear.

  6. Life cycle assessment of a power tower concentrating solar plant and the impacts of key design alternatives.

    Science.gov (United States)

    Whitaker, Michael B; Heath, Garvin A; Burkhardt, John J; Turchi, Craig S

    2013-06-04

    A hybrid life cycle assessment (LCA) is used to evaluate four sustainability metrics over the life cycle of a power tower concentrating solar power (CSP) facility: greenhouse gas (GHG) emissions, water consumption, cumulative energy demand (CED), and energy payback time (EPBT). The reference design is for a dry-cooled, 106 MW(net) power tower facility located near Tucson, AZ that uses a mixture of mined nitrate salts as the heat transfer fluid and storage medium, a two-tank thermal energy storage system designed for six hours of full load-equivalent storage, and receives auxiliary power from the local electric grid. A thermocline-based storage system, synthetically derived salts, and natural gas auxiliary power are evaluated as design alternatives. Over its life cycle, the reference plant is estimated to have GHG emissions of 37 g CO2eq/kWh, consume 1.4 L/kWh of water and 0.49 MJ/kWh of energy, and have an EPBT of 15 months. Using synthetic salts is estimated to increase GHG emissions by 12%, CED by 7%, and water consumption by 4% compared to mined salts. Natural gas auxiliary power results in greater than 10% decreases in GHG emissions, water consumption, and CED. The thermocline design is most advantageous when coupled with the use of synthetic salts.

  7. Ponce de Leon Inlet, FL: An Integrated Hydrodynamic and Morphologic Assessment of Design Alternatives using the U.S. Army Corps of Engineers’ Coastal Modeling System

    Science.gov (United States)

    2009-07-01

    Ponce de Leon Inlet, FL: An Integrated Hydrodynamic and Morphologic Assessment of Design Alternatives using the U.S. Army Corps of Engineers...DATES COVERED - 4. TITLE AND SUBTITLE Ponce de Leon Inlet, FL: An Integrated Hydrodynamic and Morphologic Assessment of Design Alternatives...SUPPLEMENTARY NOTES 14. ABSTRACT Shoaling and channel migration at Ponce de Leon Inlet, FL, have caused persistently hazardous navigation conditions

  8. An Efficient Method to Design Premature End-of-Life Trajectories: A Hypothetical Alternate Fate for Cassini

    Science.gov (United States)

    Vaquero, Mar; Senent, Juan

    2015-01-01

    What would happen if, hypothetically, the highly successful Cassini mission were to end prematurely due to lack of propellant or sudden subsystem failure? A solid plan to quickly produce a solution for any given scenario, regardless of where the spacecraft is along its reference path, must be in place to safely dispose of the spacecraft and meet all planetary protection requirements. As a contingency plan for this hypothetical situation, a method to design viable high-fidelity terminating trajectories based on a hybrid approach that exploits two-body and three-body flyby transfers combined with a numerical optimization scheme is detailed in this paper.

  9. On the solution of mixed-integer nonlinear programming models for computer aided molecular design.

    Science.gov (United States)

    Ostrovsky, Guennadi M; Achenie, Luke E K; Sinha, Manish

    2002-11-01

    This paper addresses the efficient solution of computer aided molecular design (CAMD) problems, which have been posed as mixed-integer nonlinear programming models. The models of interest are those in which the number of linear constraints far exceeds the number of nonlinear constraints, and with most variables participating in the nonconvex terms. As a result global optimization methods are needed. A branch-and-bound algorithm (BB) is proposed that is specifically tailored to solving such problems. In a conventional BB algorithm, branching is performed on all the search variables that appear in the nonlinear terms. This translates to a large number of node traversals. To overcome this problem, we have proposed a new strategy for branching on a set of linear branchingfunctions, which depend linearly on the search variables. This leads to a significant reduction in the dimensionality of the search space. The construction of linear underestimators for a class of functions is also presented. The CAMD problem that is considered is the design of optimal solvents to be used as cleaning agents in lithographic printing.

  10. Design requirements, challenges, and solutions for high-temperature falling particle receivers

    Science.gov (United States)

    Christian, Joshua; Ho, Clifford

    2016-05-01

    Falling particle receivers (FPR) utilize small particles as a heat collecting medium within a cavity receiver structure. Previous analysis for FPR systems include computational fluid dynamics (CFD), analytical evaluations, and experiments to determine the feasibility and achievability of this CSP technology. Sandia National Laboratories has fabricated and tested a 1 MWth FPR that consists of a cavity receiver, top hopper, bottom hopper, support structure, particle elevator, flux target, and instrumentation. Design requirements and inherent challenges were addressed to enable continuous operation of flowing particles under high-flux conditions and particle temperatures over 700 °C. Challenges include being able to withstand extremely high temperatures (up to 1200°C on the walls of the cavity), maintaining particle flow and conveyance, measuring temperatures and mass flow rates, filtering out debris, protecting components from direct flux spillage, and measuring irradiance in the cavity. Each of the major components of the system is separated into design requirements, associated challenges and corresponding solutions. The intent is to provide industry and researchers with lessons learned to avoid pitfalls and technical problems encountered during the development of Sandia's prototype particle receiver system at the National Solar Thermal Test Facility (NSTTF).

  11. Active lower limb prosthetics: a systematic review of design issues and solutions.

    Science.gov (United States)

    Windrich, Michael; Grimmer, Martin; Christ, Oliver; Rinderknecht, Stephan; Beckerle, Philipp

    2016-12-19

    This paper presents a review on design issues and solutions found in active lower limb prostheses. This review is based on a systematic literature search with a methodical search strategy. The search was carried out across four major technical databases and the retrieved records were screened for their relevance. A total of 21 different active prostheses, including 8 above-knee, 9 below-knee and 4 combined knee-ankle prostheses were identified. While an active prosthesis may help to restore the functional performance of an amputee, the requirements regarding the actuation unit as well as for the control system are high and the development becomes a challenging task. Regarding mechanical design and the actuation unit high force/torque delivery, high efficiency, low size and low weight are conflicting goals. The actuation principle and variable impedance actuators are discussed. The control system is paramount for a "natural functioning" of the prosthesis. The control system has to enable locomotion and should react to the amputee's intent. For this, multi-level control approaches are reviewed.

  12. Fluoride removal from diluted solutions by Donnan dialysis using full factorial design

    Energy Technology Data Exchange (ETDEWEB)

    Boubakri, Ali; Helali, Nawel; Tlili, Mohamed; Amor, Mohamed Ben [Center of Researches and Water Technologies, Soliman (Turkey)

    2014-03-15

    Excessive fluoride concentration in potable water can lead to fluorosis of teeth and bones. In the present study, Donnan dialysis (DD) is applied for the removal of fluoride ions from diluted sodium fluoride solutions. A four factor two level (2{sup 4}) full factorial design was used to investigate the influence of different physico-chemical parameters on fluoride removal efficiency (Y{sub F}) and fluoride flux (J{sub F}) through anion exchange membrane. The statistical design determines factors which have the important effects on Donnan dialysis performance and studies all interactions among the considered parameters. The four significant factors were initial fluoride concentration, feed flow rate, temperature and agitation speed. The experimental results and statistical analysis show that the temperature and agitation speed have positive effects on fluoride removal efficiency and the initial fluoride concentration has a negative effect. In the case of fluoride flux, feed flow rate and initial concentration are the main effect and all factors have a positive effect. The interaction between studied parameters was not negligible on two responses. A maximum fluoride removal of 75.52% was obtained under optimum conditions and the highest value of fluoride flux obtained was 2.4 mg/cm{sup 2}·h. Empirical regression models were also obtained and used to predict the flux and the fluoride removal profiles with satisfactory results.

  13. Alternative Evaluation Designs for Data-Centered Technology-Based Geoscience Education Projects

    Science.gov (United States)

    Zalles, D. R.

    2012-12-01

    This paper will present different strategies for how to evaluate contrasting K-12 geoscience classroom-based interventions with different goals, leveraging the first author's experiences as principal investigator of four NSF and NASA-funded geoscience education projects. Results will also be reported. Each project had its own distinctive features but all had in common the broad goal of bringing to high school classrooms uses of real place-based geospatial data to study the relationships of Earth system phenomena to climate change and sustainability. The first project's goal was to produce templates and exemplars for curriculum and assessment designs around studying contrasting geoscience topics with different data sets and forms of data representation. The project produced a near transfer performance assessment task in which students who studied climate trends in Phoenix turned their attention to climate in Chicago. The evaluation looked at the technical quality of the assessment instrument as measured by inter-rater reliability. It then analyzed the assessment results against student responses to the instructional tasks about Phoenix. The evaluation proved useful in pinpointing areas of student strength and weakness on different inquiry tasks, from simple map interpretation to analysis of contrasting claims about what the data indicate. The goal of the second project was to produce an exemplar curriculum unit that bridges Western science and traditional American Indian ecological knowledge for student learning and skill building about local environmental sustainability issues. The evaluation looked at the extent to which Western and traditional perspectives were incorporated into the design of the curriculum. The curriculum was not constructed with a separate assessment, yet evidence centered design was utilized to extrapolate from the exemplar unit templates for future instructional and assessment tasks around other places, other sustainability problems, and

  14. Designing instruction to support mechanical reasoning: Three alternatives in the simple machines learning environment

    Science.gov (United States)

    McKenna, Ann Frances

    2001-07-01

    Creating a classroom environment that fosters a productive learning experience and engages students in the learning process is a complex endeavor. A classroom environment is dynamic and requires a unique synergy among students, teacher, classroom artifacts and events to achieve robust understanding and knowledge integration. This dissertation addresses this complex issue by developing, implementing, and investigating the simple machines learning environment (SIMALE) to support students' mechanical reasoning and understanding. SIMALE was designed to support reflection, collaborative learning, and to engage students in generative learning through multiple representations of concepts and successive experimentation and design activities. Two key components of SIMALE are an original web-based software tool and hands-on Lego activities. A research study consisting of three treatment groups was created to investigate the benefits of hands-on and web-based computer activities on students' analytic problem solving ability, drawing/modeling ability, and conceptual understanding. The study was conducted with two populations of students that represent a diverse group with respect to gender, ethnicity, academic achievement and social/economic status. One population of students in this dissertation study participated from the Mathematics, Engineering, and Science Achievement (MESA) program that serves minorities and under-represented groups in science and mathematics. The second group was recruited from the Academic Talent Development Program (ATDP) that is an academically competitive outreach program offered through the University of California at Berkeley. Results from this dissertation show success of the SIMALE along several dimensions. First, students in both populations achieved significant gains in analytic problem solving ability, drawing/modeling ability, and conceptual understanding. Second, significant differences that were found on pre-test measures were eliminated

  15. Designing a solution to enable agency-academic scientific collaboration for disasters

    Science.gov (United States)

    Mease, Lindley A.; Gibbs-Plessl, Theodora; Erickson, Ashley; Ludwig, Kristin A.; Reddy, Christopher M.; Lubchenco, Jane

    2017-01-01

    As large-scale environmental disasters become increasingly frequent and more severe globally, people and organizations that prepare for and respond to these crises need efficient and effective ways to integrate sound science into their decision making. Experience has shown that integrating nongovernmental scientific expertise into disaster decision making can improve the quality of the response, and is most effective if the integration occurs before, during, and after a crisis, not just during a crisis. However, collaboration between academic, government, and industry scientists, decision makers, and responders is frequently difficult because of cultural differences, misaligned incentives, time pressures, and legal constraints. Our study addressed this challenge by using the Deep Change Method, a design methodology developed by Stanford ChangeLabs, which combines human-centered design, systems analysis, and behavioral psychology. We investigated underlying needs and motivations of government agency staff and academic scientists, mapped the root causes underlying the relationship failures between these two communities based on their experiences, and identified leverage points for shifting deeply rooted perceptions that impede collaboration. We found that building trust and creating mutual value between multiple stakeholders before crises occur is likely to increase the effectiveness of problem solving. We propose a solution, the Science Action Network, which is designed to address barriers to scientific collaboration by providing new mechanisms to build and improve trust and communication between government administrators and scientists, industry representatives, and academic scientists. The Science Action Network has the potential to ensure cross-disaster preparedness and science-based decision making through novel partnerships and scientific coordination.

  16. Designing a solution to enable agency-academic scientific collaboration for disasters

    Directory of Open Access Journals (Sweden)

    Lindley A. Mease

    2017-06-01

    Full Text Available As large-scale environmental disasters become increasingly frequent and more severe globally, people and organizations that prepare for and respond to these crises need efficient and effective ways to integrate sound science into their decision making. Experience has shown that integrating nongovernmental scientific expertise into disaster decision making can improve the quality of the response, and is most effective if the integration occurs before, during, and after a crisis, not just during a crisis. However, collaboration between academic, government, and industry scientists, decision makers, and responders is frequently difficult because of cultural differences, misaligned incentives, time pressures, and legal constraints. Our study addressed this challenge by using the Deep Change Method, a design methodology developed by Stanford ChangeLabs, which combines human-centered design, systems analysis, and behavioral psychology. We investigated underlying needs and motivations of government agency staff and academic scientists, mapped the root causes underlying the relationship failures between these two communities based on their experiences, and identified leverage points for shifting deeply rooted perceptions that impede collaboration. We found that building trust and creating mutual value between multiple stakeholders before crises occur is likely to increase the effectiveness of problem solving. We propose a solution, the Science Action Network, which is designed to address barriers to scientific collaboration by providing new mechanisms to build and improve trust and communication between government administrators and scientists, industry representatives, and academic scientists. The Science Action Network has the potential to ensure cross-disaster preparedness and science-based decision making through novel partnerships and scientific coordination.

  17. Methodology for the nuclear design validation of an Alternate Emergency Management Centre (CAGE

    Directory of Open Access Journals (Sweden)

    Hueso César

    2017-01-01

    Full Text Available The methodology is devised by coupling different codes. The study of weather conditions as part of the data of the site will determine the relative concentrations of radionuclides in the air using ARCON96. The activity in the air is characterized depending on the source and release sequence specified in NUREG-1465 by RADTRAD code, which provides results of the inner cloud source term contribution. Known activities and energy spectra are inferred using ORIGEN-S, which are used as input for the models of the outer cloud, filters and containment generated with MCNP5. The sum of the different contributions must meet the conditions of habitability specified by the CSN (Spanish Nuclear Regulatory Body (TEDE <50 mSv and equivalent dose to the thyroid <500 mSv within 30 days following the accident doses so that the dose is optimized by varying parameters including CAGE location, flow filtering need for recirculation, thicknesses and compositions of the walls, etc. The results for the most penalizing area meet the established criteria, and therefore the CAGE building design based on the methodology presented is radiologically validated.

  18. Endocrinology in field studies: problems and solutions for the experimental design.

    Science.gov (United States)

    Fusani, Leonida

    2008-07-01

    The increasing interest in hormones among field biologists can be frustrating because of the difficulties of applying classical endocrinological methods to natural settings. A few thoroughly tested methods have become popular because of their simplicity of use. This does not mean that such methods are the best or the appropriate ones for all studies. In this brief review I will examine some common problems encountered by field biologists who want to study the relationships between a morphological, behavioral, or physiological trait and a hormone. First, I will discuss why questions asked in the field often differ substantially from those asked in the laboratory, and how to adapt the design of the experiment accordingly. Second, I will review alternative methods to study hormone-trait relationships and how to combine them to strengthen the conclusions that can be drawn from the study. Then, I will discuss how to find the right control for a hormonal manipulation. Finally, I will examine the pitfalls associated with long-term hormonal treatment and the available methods for such types of studies.

  19. Initial rollover effectiveness evaluation of an alternative seat belt design for agricultural tractors.

    Science.gov (United States)

    Rains, G C

    2000-02-01

    A test program was conducted to determine the effectiveness of a seat belt restraint in preventing occupant movement in a rollover accident. A baseline type-2 seat belt (pelvic and torso restraint), and an improved type-2 seat belt restraint, both designed to restrict occupant motion in a rollover accident, were tested in a rollover restraints tester (RRT). Each seat belt was placed on a H-III 50th percentile male dummy and testing conducted at a single roll rate and two D-ring adjustment positions. Each test simulated what was approximately a 260 degrees per second rollover parallel to the longitudinal axis of the tractor with the top of the ROPS impacting the ground after 180 degrees of roll. Forces on the dummy's head and neck were measured, and video was taken to measure the head motion in the x-, y-, and z-axis of the dummy. The average vertical, forward, and lateral head movement in the baseline seat belt was 144, 222, and 184 mm, respectively, when the adjustable D-ring anchorage supporting the shoulder belt was in its lowest position. At the lowest D-ring height, the shoulder belt became ineffective and the seat belt performance became similar to a type-1 restraint (required for tractors with ROPS) resulting in increased vertical, forward, and lateral movement. The improved restraint reduced vertical head movement by as much as 75% without increasing head and neck loads above established injury criteria. Testing seat belts for rollover effectiveness will become increasingly important as seat belt usage on tractors with ROPS increases.

  20. Study of the liquid-film-forming apparatus as an alternative aeration system: design criteria and operating condition.

    Science.gov (United States)

    Hongprasith, Narapong; Imai, Tsuyoshi; Painmanakul, Pisut

    2017-06-01

    Aeration is an important factor in aquaculture systems because it is a vital condition for all organisms that live in water and respire aerobically. Generally, mechanical surface aerators are widely used in Thailand due to their advantage for increasing dissolved oxygen (DO) and for their horizontal mixing of aquaculture ponds with large surface areas. However, these systems still have some drawbacks, primarily the low oxygen transfer efficiency (OTE) and energy. Regarding this issue, alternative aeration systems should be studied and applied. Therefore, this research aims to study the aeration mechanism obtained by the diffused-air aeration combined with a liquid-film-forming apparatus (LFFA). The effect of gas flow rates, types, and patterns of aerator installation were investigated in an aquaculture pond of 10 m × 10 m × 1.5 m. The analytical parameters were volumetric mass transfer coefficient (kLa), OTE, and aeration efficiency (AE). From the results, the '4-D' with partitions was proposed as the suitable pattern for the LFFA installation. The advantage could be obtained from high energy performance with 1.2 kg/kW h of AE. Then, the operation conditions can be applied as a design guideline for this alternative aeration system in the aquaculture ponds.

  1. The regression discontinuity design showed to be a valid alternative to a randomized controlled trial for estimating treatment effects.

    Science.gov (United States)

    Maas, Iris L; Nolte, Sandra; Walter, Otto B; Berger, Thomas; Hautzinger, Martin; Hohagen, Fritz; Lutz, Wolfgang; Meyer, Björn; Schröder, Johanna; Späth, Christina; Klein, Jan Philipp; Moritz, Steffen; Rose, Matthias

    2017-02-01

    To compare treatment effect estimates obtained from a regression discontinuity (RD) design with results from an actual randomized controlled trial (RCT). Data from an RCT (EVIDENT), which studied the effect of an Internet intervention on depressive symptoms measured with the Patient Health Questionnaire (PHQ-9), were used to perform an RD analysis, in which treatment allocation was determined by a cutoff value at baseline (PHQ-9 = 10). A linear regression model was fitted to the data, selecting participants above the cutoff who had received the intervention (n = 317) and control participants below the cutoff (n = 187). Outcome was PHQ-9 sum score 12 weeks after baseline. Robustness of the effect estimate was studied; the estimate was compared with the RCT treatment effect. The final regression model showed a regression coefficient of -2.29 [95% confidence interval (CI): -3.72 to -.85] compared with a treatment effect found in the RCT of -1.57 (95% CI: -2.07 to -1.07). Although the estimates obtained from two designs are not equal, their confidence intervals overlap, suggesting that an RD design can be a valid alternative for RCTs. This finding is particularly important for situations where an RCT may not be feasible or ethical as is often the case in clinical research settings. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Apoptosis of rat liver in cold preser vation with custom-designed K YL solution

    Institute of Scientific and Technical Information of China (English)

    Li Li; Chun-Man Li; Bing-Yan Zhang; Ming-Dao Hu; Xiao-Yan Li; Jiang-Hua Ran; Ming Huang

    2007-01-01

    BACKGROUND:A suitable perfusate is very important in reducing various problems in liver preservation, prolonging the time of organ preservation and enhancing the quality of donor tissue. University of Wisconsin (UW) solution is the most successful solution for preserving multiple organs at present, but it has many shortcomings. We set out to develop a new liver preservation solution (KYL solution) and study its effects on apoptosis in rat liver undergoing cold preservation. METHODS: Using non-circulated isolated perfused rat liver (IPRL), we randomly preserved Sprague-Dawley rat livers for 0, 4, 8, 16, 24, and 48 hours with KYL solution or UW solution. The effects were assessed by measuring the content of free radicals in Krebs-Henseleit solution and the intracellular calcium content of hepatocytes, assessing hepatocellular apoptosis and related-gene expression, and observing the morphological changes in liver. To evaluate the protection by KYL and UW solutions in rat liver perfusion and preservation, we chosed normal saline for negative comparison. RESULTS: The intracellular calcium content of the liver preserved in KYL solution was less than that preserved in UW solution. At every different period of preservation, the malonaldehyde and superoxide dismutase content in Krebs-Henseleit solution, the percentage of apoptotic cells and the expression patterns of apoptosis-related-genes were similar in livers preserved in KYL and UW solutions. Morphological changes in the two groups were almost the same. The variables in both groups were better than those of livers preserved in normal saline. Both KYL and UW solutions protected rat liver from ischemia-reperfusion injury. CONCLUSIONS:KYL solution is superior to UW solution in preventing calcium overload. More severe hepatocyte damage may appear in the KYL group than in the UW group and the effect of KYL solution on apoptosis in rat liver preservation is similar to that of UW solution.

  3. Irradiation alternative method of manganese sulfate solution by a Pu-Be source for efficiency measurements; Metodo alternativo de irradiacao da solucao de sulfato de manganes por uma fonte de Pu-Be para medicoes de eficiencia

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Fellipe Souza da; Martins, Marcelo Marques; Pereira, Walsan Wagner, E-mail: fellipess@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    This study intends to create an alternative irradiation system from a Plutonium-Beryllium source for manganese sulphate solution using the Monte Carlo code. Thus seeking to eliminate the issue of institutes that do not have reactors or particle accelerators in its infrastructure, in order to optimize and provide independence for them to carry out efficiency measurements of MnSO{sub 4} solution in their own locality. The Monte Carlo simulations defined the technical features of this new system so that the solution reaches the maximum neutron capture by manganese in solution. (author)

  4. Catalysis for alternative energy generation

    CERN Document Server

    2012-01-01

    Summarizes recent problems in using catalysts in alternative energy generation and proposes novel solutions  Reconsiders the role of catalysis in alternative energy generation  Contributors include catalysis and alternative energy experts from across the globe

  5. Compositional Modeling for Optimum Design of Water-Alternating CO2-LPG EOR under Complicated Wettability Conditions

    Directory of Open Access Journals (Sweden)

    Jinhyung Cho

    2015-01-01

    Full Text Available The addition of LPG to the CO2 stream leads to minimum miscible pressure (MMP reduction that causes more oil swelling and interfacial tension reduction compared to CO2 EOR, resulting in improved oil recovery. Numerical study based on compositional simulation has been performed to examine the injectivity efficiency and transport behavior of water-alternating CO2-LPG EOR. Based on oil, CO2, and LPG prices, optimum LPG concentration and composition were designed for different wettability conditions. Results from this study indicate how injected LPG mole fraction and butane content in LPG affect lowering of interfacial tension. Interfacial tension reduction by supplement of LPG components leads to miscible condition causing more enhanced oil recovery. The maximum enhancement of oil recovery for oil-wet reservoir is 50% which is greater than 22% for water-wet reservoir. According to the result of net present value (NPV analysis at designated oil, CO2, propane, and butane prices, the optimal injected LPG mole fraction and composition exist for maximum NPV. At the case of maximum NPV for oil-wet reservoir, the LPG fraction is about 25% in which compositions of propane and butane are 37% and 63%, respectively. For water-wet reservoir, the LPG fraction is 20% and compositions of propane and butane are 0% and 100%.

  6. Dynamic cellular manufacturing system design considering alternative routing and part operation tradeoff using simulated annealing based genetic algorithm

    Indian Academy of Sciences (India)

    KAMAL DEEP; PARDEEP K SINGH

    2016-09-01

    In this paper, an integrated mathematical model of multi-period cell formation and part operation tradeoff in a dynamic cellular manufacturing system is proposed in consideration with multiple part process route. This paper puts emphasize on the production flexibility (production/subcontracting part operation) to satisfy the product demand requirement in different period segments of planning horizon considering production capacity shortage and/or sudden machine breakdown. The proposed model simultaneously generates machine cells and part families and selects the optimum process route instead of the user specifying predetermined routes. Conventional optimization method for the optimal cell formation problem requires substantial amount of time and memory space. Hence a simulated annealing based genetic algorithm is proposed to explore the solution regions efficiently and to expedite the solution search space. To evaluate the computability of the proposed algorithm, different problem scenarios are adopted from literature. The results approve the effectiveness of theproposed approach in designing the manufacturing cell and minimization of the overall cost, considering various manufacturing aspects such as production volume, multiple process route, production capacity, machine duplication, system reconfiguration, material handling and subcontracting part operation.

  7. Diclofenac sodium topical solution with dimethyl sulfoxide, a viable alternative to oral nonsteroidal anti-inflammatories in osteoarthritis: review of current evidence

    Directory of Open Access Journals (Sweden)

    Fuller P

    2011-07-01

    Full Text Available Philip Fuller¹, Sanford Roth²¹Covidien, Hazelwood, MO; ²Arizona Research and Education, Arthritis Research Laboratory, Arizona State University, Phoenix, AZ, USAAbstract: Topical nonsteroidal anti-inflammatory drugs (NSAIDs may offer a safer alternative to their oral counterparts for the management of osteoarthritis. Diclofenac sodium topical solution with dimethyl sulfoxide (TDiclo was evaluated in five randomized, controlled trials and is indicated for treatment of the signs and symptoms associated with osteoarthritis of the knee. Three studies showed that TDiclo is superior to placebo and vehicle control with respect to pain, physical function, and perception of osteoarthritis symptoms. Two studies showed that benefits are similar to those of oral diclofenac, with one study demonstrating statistical equivalence. The most common adverse event associated with TDiclo in these studies was dry skin. Incidences of gastrointestinal adverse events and abnormal levels of liver enzymes were lower with TDiclo compared with oral diclofenac in active-controlled studies. Based on these studies, TDiclo represents a practical, evidence-based option for the management of osteoarthritis of the knee.Keywords: osteoarthritis, nonsteroidal anti-inflammatory drugs, diclofenac, topical analgesic

  8. Design and Construction of Experiment for Direct Electron Irradiation of Uranyl Sulfate Solution: Bubble Formation and Thermal Hydraulics Studies

    Energy Technology Data Exchange (ETDEWEB)

    Chemerisov, Sergey [Argonne National Lab. (ANL), Argonne, IL (United States); Gromov, Roman [Argonne National Lab. (ANL), Argonne, IL (United States); Makarashvili, Vakho [Argonne National Lab. (ANL), Argonne, IL (United States); Heltemes, Thad [Argonne National Lab. (ANL), Argonne, IL (United States); Sun, Zaijing [Argonne National Lab. (ANL), Argonne, IL (United States); Wardle, Kent E. [Argonne National Lab. (ANL), Argonne, IL (United States); Bailey, James [Argonne National Lab. (ANL), Argonne, IL (United States); Quigley, Kevin [Argonne National Lab. (ANL), Argonne, IL (United States); Stepinski, Dominique [Argonne National Lab. (ANL), Argonne, IL (United States); Vandegrift, George [Argonne National Lab. (ANL), Argonne, IL (United States)

    2014-10-01

    Argonne is assisting SHINE Medical Technologies in developing SHINE, a system for producing fission-product 99Mo using a D/T-accelerator to produce fission in a non-critical target solution of aqueous uranyl sulfate. We have developed an experimental setup for studying thermal-hydraulics and bubble formation in the uranyl sulfate solution to simulate conditions expected in the SHINE target solution during irradiation. A direct electron beam from the linac accelerator will be used to irradiate a 20 L solution (sector of the solution vessel). Because the solution will undergo radiolytic decomposition, we will be able to study bubble formation and dynamics and effects of convection and temperature on bubble behavior. These experiments will serve as a verification/ validation tool for the thermal-hydraulic model. Utilization of the direct electron beam for irradiation allows homogeneous heating of a large solution volume and simplifies observation of the bubble dynamics simultaneously with thermal-hydraulic data collection, which will complement data collected during operation of the miniSHINE experiment. Irradiation will be conducted using a 30-40 MeV electron beam from the high-power linac accelerator. The total electron-beam power will be 20 kW, which will yield a power density on the order of 1 kW/L. The solution volume will be cooled on the front and back surfaces and central tube to mimic the geometry of the proposed SHINE solution vessel. Also, multiple thermocouples will be inserted into the solution vessel to map thermal profiles. The experimental design is now complete, and installation and testing are in progress.

  9. The Solution to Pollution is Distribution: Design Your Own Chaotic Flow

    Science.gov (United States)

    Tigera, R. G.; Roth, E. J.; Neupauer, R.; Mays, D. C.

    2015-12-01

    Plume spreading promotes the molecular mixing that drives chemical reactions in porous media in general, and remediation reactions in groundwater aquifers in particular. Theoretical analysis suggests that engineered injection and extraction, a specific sequence of pumping through wells surrounding a contaminant plume, can improve groundwater remediation through chaotic advection. Selection of an engineered injection and extraction scheme is difficult, however, because the engineer is faced with the difficulty of recommending a pumping scheme for a contaminated site without having any previous knowledge of how the scheme will perform. To address this difficulty, this presentation describes a Graphical User Interface (GUI) designed to help engineers develop, test, and observe pumping schemes as described in previous research (Mays, D.C. and Neupauer, R.M., 2012, Plume spreading in groundwater by stretching and folding, Water Resour. Res., 48, W07501, doi:10.1029/2011WR011567). The inputs allow the user to manipulate the model conditions such as number of wells, plume size, and pumping scheme. Plume evolution is modeled, assuming no diffusion or dispersion, using analytical solutions for injection or extraction through individual wells or pairs or wells (i.e., dipoles). Using the GUI, an engineered injection and extraction scheme can be determined that best fits the remediation needs of the contaminated site. By creating multiple injection and extraction schemes, the user can learn about the plume shapes created from different schemes and, ultimately, recommend a pumping scheme based on some experience of fluid flow as shown in the GUI. The pumping schemes developed through this GUI are expected to guide more advanced modeling and laboratory studies that account for the crucial role of dispersion in groundwater remediation.

  10. THE EVALUATION SYSTEM OF DESIGN SOLUTIONS FOR RESIDENTIAL PROPERTY ON THE PRE-INVESTMENT STAGE THROUGH NEURAL NETWORK TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    G. D. Kostsikava

    2016-01-01

    Full Text Available Ever since the Soviet Union design solutions were evaluated according to different criteria and indicators. At the present stage of evaluation systems of design solutions stands systemengineering doctrine is allocated. It is complemented by the theory of efficiency and financial sustainability investment project in view of the general market concept. Also great attention is paid to the virtual object modeling. It is urgent to include the behavior prediction of an investment construction project model at each stage of its life cycle. The high cost of all phases of this life cycle makes it necessary to calculate the feasibility of the investment. Very urgent to do it as accurately as possible and before we start of design works on the stage of the investment plan evaluation. Belarus has legislated pre-investment stage of construction project development. To evaluate the design solution at this stage is necessary to develop an investment justification, a project management plan and a business plan. They will evaluate and will compare several options for future objects by the complex. This requires not only time, but considerable financial costs. In order to optimize the process to develop an evaluation system design solutions based on existing projects. It allows the customer (investor choose design solutions to build the object without developing of pre-design documentations for several options. This system it is advisable to try out the example of apartment house building with the assistance of the national fund of project documentation and objects-analogues data bank. The developed evaluation system of design solutions for residential real estate objects in the pre-investment stage is supposed to use the theory of neural networks and neyroprogramming. This system bases on the input parameters projects. The hidden layer neurons are trained to choose suitable projects of apartment houses with their classification. The projects will be classified

  11. Design and synthesis of molecular donors for solution-processed high-efficiency organic solar cells.

    Science.gov (United States)

    Coughlin, Jessica E; Henson, Zachary B; Welch, Gregory C; Bazan, Guillermo C

    2014-01-21

    Organic semiconductors incorporated into solar cells using a bulk heterojunction (BHJ) construction show promise as a cleaner answer to increasing energy needs throughout the world. Organic solar cells based on the BHJ architecture have steadily increased in their device performance over the past two decades, with power conversion efficiencies reaching 10%. Much of this success has come with conjugated polymer/fullerene combinations, where optimized polymer design strategies, synthetic protocols, device fabrication procedures, and characterization methods have provided significant advancements in the technology. More recently, chemists have been paying particular attention to well-defined molecular donor systems due to their ease of functionalization, amenability to standard organic purification and characterization methods, and reduced batch-to-batch variability compared to polymer counterparts. There are several critical properties for efficient small molecule donors. First, broad optical absorption needs to extend towards the near-IR region to achieve spectral overlap with the solar spectrum. Second, the low lying highest occupied molecular orbital (HOMO) energy levels need to be between -5.2 and -5.5 eV to ensure acceptable device open circuit voltages. Third, the structures need to be relatively planar to ensure close intermolecular contacts and high charge carrier mobilities. And last, the small molecule donors need to be sufficiently soluble in organic solvents (≥10 mg/mL) to facilitate solution deposition of thin films of appropriate uniformity and thickness. Ideally, these molecules should be constructed from cost-effective, sustainable building blocks using established, high yielding reactions in as few steps as possible. The structures should also be easy to functionalize to maximize tunability for desired properties. In this Account, we present a chronological description of our thought process and design strategies used in the development of highly

  12. Trends in Modelling, Simulation and Design of Water Hydraulic Systems – Motion Control and Open-Ended Solutions

    DEFF Research Database (Denmark)

    Conrad, Finn

    2006-01-01

    The paper presents and discusses a R&D-view on trends in development and best practise in modelling, simulation and design of both low-pressure and high-pressure tap water hydraulic components and systems for motion control as well as open-ended solutions various industrial applications. The focus...

  13. Design of green spaces located below the urbanised level. Themes, problems and solutions applied to a case study

    Directory of Open Access Journals (Sweden)

    Alessandro Toccolini

    2015-12-01

    Full Text Available The design of green areas and landscape is often related to spaces with special features, which, due to their territorial peculiarities, require the adoption of appropriate design solutions. This category includes spaces located below the urbanised/street level (or on different levels, which may have various origins: areas derived from the regeneration of defensive ditches that, after having lost their original function, have become centres of urban aggregation (ancient city walls, castles moats; sites derived from the demolition of buildings or other structures; spaces created expressly sub-level as a result of design choices. This paper deals with some design issues concerning those places, in relation to orography, vegetation and the type of users expected. Moreover, the opinion of the population is taken into account to clearly define design choices; the issue is explored using special techniques to involve citizens in the design process, namely focus groups and surveys aimed at identifying their needs. The paper, finally, presents a design experience applied to a study area in the municipality of Abbiategrasso (Lombardy region, Italy located under the urbanised level and currently used as urban park (the so-called Fossa Viscontea. This park (about 3.7 ha occupies the area of the ancient defensive moat of the historical village (including the Visconti Castle - 13th century; design solutions are proposed for ensuring accessibility and fruition of this area such as leisure and aggregation centre.

  14. Clearfell controversies and alternative timber harvest designs: how acceptability perceptions vary between Tasmania and the U.S. Pacific Northwest.

    Science.gov (United States)

    Ribe, Robert G; Ford, Rebecca M; Williams, Kathryn J H

    2013-01-15

    Perceptions of the acceptability of alternative "variable retention" timber harvests, that keep trees standing in harvested areas, were compared between regions beset by major forestry conflicts. Data from similar studies of similar harvest systems were compared between Oregon and Tasmania. These comparisons were related to attitudes and to differences in ecosystems, silvicultural prescriptions, forestry outcomes, aesthetics, and social-political context. Findings showed that perceptions measured in one region cannot be assumed valid in another. Substantial regional differences arose not from general sociological differences but from differences in local forestry outcomes. These largely arose from different regeneration requirements of commercial tree species and consequent differences in the design of otherwise analogous harvests. Comparisons of perceptions by people with similar attitudes yielded substantial regional differences. Those prioritizing ecological conservation were mainly influenced by habitat outcomes, and consequently preferred harvests with aggregated tree retention patterns in Tasmania but not in Oregon. People sympathetic to timber industry interests in both regions showed little association between forestry outcomes and acceptability and favoured more intensive harvests. Tasmanian harvest advocates perceived harvests that keep more standing trees as less acceptable than those in Oregon. This may be due to sampling differences or to greater risk perceptions towards new harvest designs in Tasmania. Tasmanians generally disliked clearfelling more than Oregonians, likely due to different political narratives framing these perceptions or to higher aesthetic impacts in Tasmania due to burning. Dispersed retention was perceived as more acceptable in Oregon than in Tasmania, likely because Oregon had much higher post-harvest tree densities. Regional differences in wildfire-risk and logger-safety were not strongly associated with different acceptability

  15. Design Mode Analysis of Pareto Solution Set for Decision-Making Support

    Directory of Open Access Journals (Sweden)

    Satoru Hiwa

    2014-01-01

    Full Text Available Decision making in engineering design problems is challenging because they have multiple and conflicting criteria and complex correlation between design parameters. This study proposes a decision-making support methodology named design mode analysis, which consists of data clustering and principal component analysis (PCA. A design mode is indicated by the eigenvector obtained by PCA and reveals the dominant design parameters in a given dataset. The proposed method is a general framework to obtain the design modes from high-dimensional and large datasets. The effectiveness of the proposed method is verified on the conceptual design problem of the hybrid rocket engine.

  16. Evaluation of Visualization Using a 50/50 (Contrast Media/Glucose 5% Solution) Technique for Radioembolization as an Alternative to a Standard Sandwich Technique.

    Science.gov (United States)

    Paprottka, Karolin J; Todica, Andrei; Ilhan, Harun; Rübenthaler, Johannes; Schoeppe, Franziska; Michl, Marlies; Heinemann, Volker; Bartenstein, Peter; Reiser, Maximilian F; Paprottka, Philipp M

    2017-06-05

    Radioembolization (RE) with (90)yttrium ((90)Y) resin microspheres generally employs a sandwich technique with separate sequential administration of contrast medium (CM), followed by vehicle (e.g., glucose 5% [G5] solution), then (90)Y resin microspheres (in G5), then G5, and then CM again to avoid contact of CM and microspheres under fluoroscopic guidance. This study evaluates the visualization quality and safety of a modified sandwich technique with a 50/50-mixture of CM (Imeron 300) and G5 for administration of (90)Y resin microspheres. A retrospective analysis of 81 RE procedures in patients with primary or secondary liver tumors was performed. The quality of angiographic visualization of the hepatic vessels was assessed before the first injection and immediately before the whole dose has been injected. Visualization and flow rate were graded on a 5-point scale: 1 = very good to 5 = not visible/no antegrade flow. Univariate logistic regression models and multiple linear regression models were used to evaluate the prognostic variables associated with visualization and flow scores. Visualization quality was inversely related to flow rate, the lower the flow rate the better the grade of the visualization. Visualization quality was also inversely related to body-mass-index (BMI). Performing RE with the 50/50-CM/G5 mixture resulted in a mean injection time for 1 GBq of 15 min. No clinically significant adverse events, including radiation-induced liver disease were reported. RE with a 50/50-mixture of CM and G5 for administration of (90)Y resin microspheres in a modified sandwich technique is a safe administration alternative and provides good visualization of hepatic vessels, which is inversely dependent on flow rate and BMI. Injection time was reduced compared with our experience with the standard sandwich technique.

  17. Property Integration - A New Approach for Simultaneous Solution of Process and Molecular Design Problems

    DEFF Research Database (Denmark)

    concepts are employed to identify optimal properties without commitment to specific species. Subsequently, group contribution methods and molecular design techniques are employed to solve the reverse property prediction problem to design molecules possessing the optimal properties....

  18. TO "LIMITATIONS OF ROI TESTING FOR VENTING DESIGN: DESCRIPTION OF AN ALTERNATIVE APPROACH BASED ON ATTAINMENT OF A CRITICAL PORE-GAS VELOCITY IN CONTAMINATED MEDIA

    Science.gov (United States)

    In this paper, we describe the limitations of radius of influence (ROI) evaluation for venting design in more detail than has been done previously and propose an alternative method based on specification and attainment of critical pore-gas velocities in contaminated subsurface me...

  19. Design of Nutrition Solution Regulating Controller for Greenhouse%温室营养液调控器的设计

    Institute of Scientific and Technical Information of China (English)

    张亮; 李树珍; 石磊; 陈立东; 马淑英; 李国防; 郑立新; 毛罕平

    2011-01-01

    [Objective] The aim was to study the design of nutrition solution regulating controller in greenhouse in order to achieve reasonable allocation of nutrient solution. [ Method ] Based on the modularized design idea, the controller using AT89C55 as main control chip was designed and its hardware was made up of setting, acquisition and control component. [ Result j The results showed that it could collect EC and pH of nutrition solution parameter. Combined with the knowledge of nutrient solution allocation and regulation and the experience of experts, reasonable allocation of nutrient solution and support for keyboard input and digital display were achieved. [Conclusion]The controller was low cost,simple and reliable operation.%[目的]研究温室营养液调控器的设计,以实现营养液的全天候合理调配.[方法]采用模块化的设计思想,以AT89C55为主控芯片设计了一套温室营养液调控器.[结果]该系统硬件由设置、采集、控制3部分组成.该营养液控制器可以实现营养液的EC、pH参数的采集,并结合作物营养液配制与调控知识和专家的经验,实现营养液合理调配,并支持键盘输入与数码显示.[结论]该控制器成本低,操作简单方便,运行可靠.

  20. The Development of Mini Portable Digester Designs for Domestic and Restaurant Solid Waste Processing to be Clean Biogas as Energy's Alternative to Replace LPG

    Science.gov (United States)

    Mansur, A.; Janari dan, D.; Setiawan, N.

    2016-02-01

    Biofuel is developed as an alternative source of second generation energy that could be attained from organic waste. This research is purposed to create applicative and cheap Portable digester unit for society. The design concepts’ screening that was made under considerations of the experts is finally resumed. Design 1 with final weight score of 1, design 2 with final weight score of -1, design 3 with final weight score of 2, design 4 with final weight score 3, design 5 with final weight score of -1, design 6 with final weight score of 0. Accepted designs for further concept assessment are design 1, 2 and 6. The result of concept assessment applies weighting for the scoring. Design 1 resulting 2.67, design 2 results 2.15 while design 3 results 2.52. Design 1 is concluded as the design with biggest result, which is 2.67. Its specification is explained as follows: tank capacity of 60 liters, manual rotating crank pivot, tank's material is plastic with symbol 1, material of axle swivel arm is grey cast iron, 2 mm rotary blades with hole. The experiment 1 contained 23.78% methane and 13.65 carbon dioxide that resulted from content test.

  1. Modeling the oldest old: personas to design technology-based solutions for older adults.

    Science.gov (United States)

    Reeder, Blaine; Zaslavksy, Oleg; Wilamowska, Katarzyna M; Demiris, George; Thompson, Hilaire J

    2011-01-01

    There is a recognized need to develop information technology for the delivery of care services to older adults. However, little attention has been paid to the design of information technology for the oldest old demographic. We made novel use of data from observations, focus groups and cluster analysis of oldest old participant characteristics from a pilot study in a community setting to iteratively construct personas for the design of information technology for the oldest old. The resulting two personas, "Hazel" and "Rose", capture different abilities of members of the oldest old demographic group. In addition, we provide a list of eleven design recommendations to guide the design of technology that supports the abilities of people like Hazel and Rose. The resulting personas, design recommendations and persona construction method can be useful tools for informaticians and designers of new systems for the oldest old.

  2. State-space solutions to the h_inf/ltr design problem

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik

    1993-01-01

    phase case, though, the order of the controllers can be reduced to n in all cases. The control problems corresponding to the various controller types are given as four different singular state-space problems, and the solutions are given in terms of the relevant equations and inequalities...

  3. Priorities in urban traffic problems and implications for the design of solutions.

    NARCIS (Netherlands)

    Vreeswijk, Jaap; Berkum, van Eric; Arem, van Bart

    2011-01-01

    The introduction of ICT in the traffic domain showed great potential, but the many opportunities this brings seems to have distracted engineers. To solve urban traffic problems, many potentially effective solutions have been developed, but deployment rates are low. The main reason seems to be that s

  4. Design of magnetic molecularly imprinted polymer nanoparticles for controlled release of doxorubicin under an alternative magnetic field in athermal conditions

    Science.gov (United States)

    Griffete, N.; Fresnais, J.; Espinosa, A.; Wilhelm, C.; Bée, A.; Ménager, C.

    2015-11-01

    An innovative magnetic delivery nanomaterial for triggered cancer therapy showing active control over drug release by using an alternative magnetic field is proposed. In vitro and In vivo release of doxorubicin (DOX) were investigated and showed a massive DOX release under an alternative magnetic field without temperature elevation of the medium.An innovative magnetic delivery nanomaterial for triggered cancer therapy showing active control over drug release by using an alternative magnetic field is proposed. In vitro and In vivo release of doxorubicin (DOX) were investigated and showed a massive DOX release under an alternative magnetic field without temperature elevation of the medium. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr06133d

  5. Modeling design iteration in product design and development and its solution by a novel artificial bee colony algorithm.

    Science.gov (United States)

    Chen, Tinggui; Xiao, Renbin

    2014-01-01

    Due to fierce market competition, how to improve product quality and reduce development cost determines the core competitiveness of enterprises. However, design iteration generally causes increases of product cost and delays of development time as well, so how to identify and model couplings among tasks in product design and development has become an important issue for enterprises to settle. In this paper, the shortcomings existing in WTM model are discussed and tearing approach as well as inner iteration method is used to complement the classic WTM model. In addition, the ABC algorithm is also introduced to find out the optimal decoupling schemes. In this paper, firstly, tearing approach and inner iteration method are analyzed for solving coupled sets. Secondly, a hybrid iteration model combining these two technologies is set up. Thirdly, a high-performance swarm intelligence algorithm, artificial bee colony, is adopted to realize problem-solving. Finally, an engineering design of a chemical processing system is given in order to verify its reasonability and effectiveness.

  6. Removal of xylenol orange from its aqueous solution using SDS self-microemulsifying systems: optimization by Box-Behnken statistical design.

    Science.gov (United States)

    Shakeel, Faiyaz; Haq, Nazrul; Alanazi, Fars K; Alsarra, Ibrahim A

    2014-04-01

    The aim of present study was to develop and evaluate sodium dodecyl sulfate (SDS) self-microemulsifying systems (SMES) for the removal of an anionic dye xylenol orange (XO) from its bulk aqueous media via liquid-liquid adsorption. The composition of SDS SMES was optimized by Box-Behnken statistical design for the maximum removal of XO from its aqueous solution. Various SDS formulations were prepared by spontaneous emulsification method and characterized for thermodynamic stability, self-microemulsification efficiency, droplet size, and viscosity. Adsorption studies were conducted at 8, 16, and 24 h by mixing small amounts of SDS formulations with relatively large amounts of bulk aqueous solution of XO. Droplet size and viscosity of SDS formulations were significantly influenced by oil phase concentration (triacetin), while surfactant concentration had little impact on droplet size and viscosity. However, the percentage of removal of XO was influenced by triacetin concentration, surfactant concentration, and adsorption time. Based on lowest droplet size (35.97 nm), lowest viscosity (29.62 cp), and highest percentage of removal efficiency (89.77 %), formulation F14, containing 2 % w/w of triacetin and 40 % w/w of surfactant mixture (20 % w/w of SDS and 20 % w/w of polyethylene glycol 400), was selected as an optimized formulation for the removal of XO from its bulk aqueous media after 16 h. These results indicated that SDS SMES could be suitable alternates of solid-liquid adsorption for the removal of toxic dyes such as XO from its aqueous solution through liquid-liquid adsorption.

  7. Bio-inspired solutions in design for manufacturing of micro fuel cell

    DEFF Research Database (Denmark)

    Omidvarnia, Farzaneh; Hansen, Hans Nørgaard

    2014-01-01

    In this paper the application of biomimetic principles in design for micro manufacturing is investigated. A micro direct methanol fuel cell (μDMFC) for power generation in hearing aid devices is considered as the case study in which the bioinspired functions are replicated. The focus in design of...

  8. Design of attitude solution algorithm for tail-sitter VTOL UAV

    Directory of Open Access Journals (Sweden)

    Donghui LIU

    2016-02-01

    Full Text Available The tail-sitter Vertical Takeoff and Landing (VTOL Unmanned Aerial Vehicle(UAV, flying in a fixed-wing model, overcomes many shortcomings of traditional fixed-wing UAVs, and inherits the advantage of high overall efficiency, which means it has great development potential and very broad application prospects. The attitude of tail-sitter VTOL UAV shows a wide change range in its takeoff and landing stages, and when the attitude sensor changes more than 90 degrees in pitch direction, the Euler angles converted by the Quaternions will have singular points, which means gimbal deadlock appears. From the solution algorithm, this paper provides a method of changing the order of rotation to avoid the appearance of singular points. The results show that this method can be well applied to the attitude solution of the VTOL UAV.

  9. Survey-Based Cross-Country Comparisons Where Countries Vary in Sample Design: Issues and Solutions

    Directory of Open Access Journals (Sweden)

    Kaminska Olena

    2017-03-01

    Full Text Available In multi-national surveys, different countries usually implement different sample designs. The sample designs affect the variance of estimates of differences between countries. When making such estimates, analysts often fail to take sufficient account of sample design. This failure occurs sometimes because variables indicating stratification, clustering, or weighting are unavailable, partially available, or in a form that is unsuitable for cross-national analysis. In this article, we demonstrate how complex sample design should be taken into account when estimating differences between countries, and we provide practical guidance to analysts and to data producers on how to deal with partial or inappropriately-coded sample design indicator variables. Using EU-SILC as a case study, we evaluate the inverse misspecification effect (imeff that results from ignoring clustering or stratification, or both in a between-country comparison where countries’ sample designs differ. We present imeff for estimates of between-country differences in a number of demographic and economic variables for 19 European Union Member States. We assess the magnitude of imeff and the associated impact on standard error estimates. Our empirical findings illustrate that it is important for data producers to supply appropriate sample design indicators and for analysts to use them.

  10. Design of Distributed Controllers Seeking Optimal Power Flow Solutions under Communication Constraints: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Dall' Anese, Emiliano; Simonetto, Andrea; Dhople, Sairaj

    2016-12-01

    This paper focuses on power distribution networks featuring inverter-interfaced distributed energy resources (DERs), and develops feedback controllers that drive the DER output powers to solutions of time-varying AC optimal power flow (OPF) problems. Control synthesis is grounded on primal-dual-type methods for regularized Lagrangian functions, as well as linear approximations of the AC power-flow equations. Convergence and OPF-solution-tracking capabilities are established while acknowledging: i) communication-packet losses, and ii) partial updates of control signals. The latter case is particularly relevant since it enables asynchronous operation of the controllers where DER setpoints are updated at a fast time scale based on local voltage measurements, and information on the network state is utilized if and when available, based on communication constraints. As an application, the paper considers distribution systems with high photovoltaic integration, and demonstrates that the proposed framework provides fast voltage-regulation capabilities, while enabling the near real-time pursuit of solutions of AC OPF problems.

  11. Design of Distributed Controllers Seeking Optimal Power Flow Solutions Under Communication Constraints

    Energy Technology Data Exchange (ETDEWEB)

    Dall' Anese, Emiliano; Simonetto, Andrea; Dhople, Sairaj

    2016-12-29

    This paper focuses on power distribution networks featuring inverter-interfaced distributed energy resources (DERs), and develops feedback controllers that drive the DER output powers to solutions of time-varying AC optimal power flow (OPF) problems. Control synthesis is grounded on primal-dual-type methods for regularized Lagrangian functions, as well as linear approximations of the AC power-flow equations. Convergence and OPF-solution-tracking capabilities are established while acknowledging: i) communication-packet losses, and ii) partial updates of control signals. The latter case is particularly relevant since it enables asynchronous operation of the controllers where DER setpoints are updated at a fast time scale based on local voltage measurements, and information on the network state is utilized if and when available, based on communication constraints. As an application, the paper considers distribution systems with high photovoltaic integration, and demonstrates that the proposed framework provides fast voltage-regulation capabilities, while enabling the near real-time pursuit of solutions of AC OPF problems.

  12. Optimized Solution of Two Bar Truss Design Using Intuitionistic Fuzzy Optimization Technique

    Directory of Open Access Journals (Sweden)

    Samir Dey

    2014-08-01

    Full Text Available The main goal of the structural optimization is to minimize the weight of structure or the vertical deflection of loaded joint while satisfying all design requirements imposed by design codes. In general fuzzy sets are used to analyze the fuzzy structural optimization. In this paper, a planer truss structural model in intuitionistic fuzzy environment has been developed. This paper proposes an intuitionistic fuzzy optimization approach to solve a non-linear programming problem in the context of a structural application. This approximation approach is used to solve structural optimization model with weight as objective function. This intuitionistic fuzzy optimization (IFO approach is illustrated on two-bar truss structural design problem. The result of the intuitionistic fuzzy optimization obtained is compared with the other results of optimization algorithms from the literary sources. It is shown that the proposed intuitionistic fuzzy optimization approach is more efficient than the analogous fuzzy technique for structural design.

  13. Technology Solutions Case Study: Design Guidance for Passive Vents in New Construction, Multifamily Buildings

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-02-12

    In an effort to improve indoor air quality in high-performance, new construction, multifamily buildings, dedicated sources of outdoor air are being implemented. Passive vents are being selected by some design teams over other strategies because of their lower first costs and operating costs. The U.S. Department of Energy’s Building America research team Consortium for Advanced Residential Buildings constructed eight steps, which outline the design and commissioning required for these passive vents to perform as intended.

  14. 公路设计中的缺陷及解决措施%Highway design defects and solutions

    Institute of Scientific and Technical Information of China (English)

    龚方涛; 陈玮

    2016-01-01

    公路在我国的交通中占有重要的一席之地,对我国的经济贡献巨大。近年来,公路的损毁问题也越来越严重,由于公路的损毁导致的交通事故屡见不鲜。因此本文对公路设计中的缺陷及解决措施进行了探讨,提出了一定可行的解决措施。这些解决措施对公路的设计具有一定的参考价值。%The road occupies an important place in our traffic, a huge contribution to our economy. In re-cent years,damaged more and more serious problem of road traffic accidents due to the damage caused by common road. Therefore,this article on the highway design flaws and solutions were discussed,and some possible solutions. These solutions have certain reference value for highway design.

  15. SOLUTION OF SIGNAL UNCERTAINTY PROBLEM AT ANALYTICAL DESIGN OF CONSECUTIVE COMPENSATOR IN PIEZO ACTUATOR CONTROL

    Directory of Open Access Journals (Sweden)

    S.V. Bystrov

    2016-05-01

    Full Text Available Subject of Research.We present research results for the signal uncertainty problem that naturally arises for the developers of servomechanisms, including analytical design of serial compensators, delivering the required quality indexes for servomechanisms. Method. The problem was solved with the use of Besekerskiy engineering approach, formulated in 1958. This gave the possibility to reduce requirements for input signal composition of servomechanisms by using only two of their quantitative characteristics, such as maximum speed and acceleration. Information about input signal maximum speed and acceleration allows entering into consideration the equivalent harmonic input signal with calculated amplitude and frequency. In combination with requirements for maximum tracking error, the amplitude and frequency of the equivalent harmonic effects make it possible to estimate analytically the value of the amplitude characteristics of the system by error and then convert it to amplitude characteristic of open-loop system transfer function. While previously Besekerskiy approach was mainly used in relation to the apparatus of logarithmic characteristics, we use this approach for analytical synthesis of consecutive compensators. Main Results. Proposed technique is used to create analytical representation of "input–output" and "error–output" polynomial dynamic models of the designed system. In turn, the desired model of the designed system in the "error–output" form of analytical representation of transfer functions is the basis for the design of consecutive compensator, that delivers the desired placement of state matrix eigenvalues and, consequently, the necessary set of dynamic indexes for the designed system. The given procedure of consecutive compensator analytical design on the basis of Besekerskiy engineering approach under conditions of signal uncertainty is illustrated by an example. Practical Relevance. The obtained theoretical results are

  16. An algebraic approach for simultaneous solution of process and molecular design problems

    Directory of Open Access Journals (Sweden)

    S. Bommareddy

    2010-09-01

    Full Text Available The property integration framework has allowed for simultaneous representation of processes and products from a properties perspective and thereby established a link between molecular and process design problems. The simultaneous approach involves solving two reverse problems. The first reverse problem identifies the property targets corresponding to the desired process performance. The second reverse problem is the reverse of a property prediction problem, which identifies the molecular structures that match the targets identified in the first problem. Group Contribution Methods (GCM are used to form molecular property operators that will be used to track properties. Earlier contributions in this area have worked to include higher order estimation of GCM for solving the molecular design problem. In this work, the accuracy of the property prediction is further enhanced by improving the techniques to enumerate higher order groups. Incorporation of these higher order enumeration techniques increases the efficiency of property prediction and thus the application range of the group contribution methods in molecular design problems. Successful tracking of properties is the key in applying the reverse problem formulation for integrated process and product design problems. An algebraic technique has been developed for solving process and molecular design problems simultaneously. Since both process and molecular property operators target the same optimum process performance, the set of inequality expressions can be solved simultaneously to identify the molecules that meet the desired process performance. Since this approach is based on an algebraic algorithm, any number of properties can be tracked simultaneously.

  17. The air transportation hub-and-spoke design problem: comparison between a continuous and a discrete solution method

    Directory of Open Access Journals (Sweden)

    Guina Sotomayor Alzamora

    2013-12-01

    Full Text Available The hub-and-spoke network design problem, also known as the hub location problem, aims to find the concentration points in a given network flow so that the sum of the distances of the linkages is minimized. In this work, we compare discrete solutions of this problem, given by the branch-and-cut method applied to the p-hub median model, with continuous solutions, given by the hyperbolic smoothing technique applied to a min-sum-min model. Computational experiments for particular instances of the Brazilian air transportation system, with the number of hubs varying from 2 to 8, are conducted with the support of a discretization heuristic and the Voronoi diagram.

  18. Mechatronic futures challenges and solutions for mechatronic systems and their designers

    CERN Document Server

    Bradley, David

    2016-01-01

    Offering a comprehensive overview of the challenges, risks and options facing the future of mechatronics, this book provides insights into how these issues are currently assessed and managed. Building on the previously published book ‘Mechatronics in Action,’ it identifies and discusses the key issues likely to impact on future mechatronic systems. It supports mechatronics practitioners in identifying key areas in design, modeling and technology and places these in the wider context of concepts such as cyber-physical systems and the Internet of Things. For educators it considers the potential effects of developments in these areas on mechatronic course design, and ways of integrating these. Written by experts in the field, it explores topics including systems integration, design, modeling, privacy, ethics and future application domains. Highlighting novel innovation directions, it is intended for academics, engineers and students working in the field of mechatronics, particularly those developing new conc...

  19. Social Innovation and New Industrial Contexts: Can Designers "Industrialize" Socially Responsible Solutions?

    DEFF Research Database (Denmark)

    Morelli, Nicola

    2007-01-01

      Many years ago Viktor Papanek urgently called for a radical revision of the design profession based on an exploration of new territories outside the market oriented logic. For many years Papanek's call was ignored, but the urgency of those theme is re-emerging, together with the need to overcome...... Papanek's approach, in view of the changed context in which industrial companies are now operating. While industrial production is globalising, local needs are becoming more and more complex, generating demand patterns and opportunities that are often ignored in the mainstream market-oriented perspective...... framework for this paper. An investigation is proposed beyond the traditional links between design and industry, emphasising new insights into the changes in the social role of industrial production. Furthermore, the paper proposes a methodological exploration to help designers focus on new actors and new...

  20. Social Innovation and New Industrial Contexts: Can Designers "Industrialize" Socially Responsible Solutions?

    DEFF Research Database (Denmark)

    Morelli, Nicola

    2007-01-01

      Many years ago Viktor Papanek urgently called for a radical revision of the design profession based on an exploration of new territories outside the market oriented logic. For many years Papanek's call was ignored, but the urgency of those theme is re-emerging, together with the need to overcome...... Papanek's approach, in view of the changed context in which industrial companies are now operating. While industrial production is globalising, local needs are becoming more and more complex, generating demand patterns and opportunities that are often ignored in the mainstream market-oriented perspective...... framework for this paper. An investigation is proposed beyond the traditional links between design and industry, emphasising new insights into the changes in the social role of industrial production. Furthermore, the paper proposes a methodological exploration to help designers focus on new actors and new...

  1. Co-design and implementation research: challenges and solutions for ethics committees.

    Science.gov (United States)

    Goodyear-Smith, Felicity; Jackson, Claire; Greenhalgh, Trisha

    2015-11-16

    Implementation science research, especially when using participatory and co-design approaches, raises unique challenges for research ethics committees. Such challenges may be poorly addressed by approval and governance mechanisms that were developed for more traditional research approaches such as randomised controlled trials. Implementation science commonly involves the partnership of researchers and stakeholders, attempting to understand and encourage uptake of completed or piloted research. A co-creation approach involves collaboration between researchers and end users from the onset, in question framing, research design and delivery, and influencing strategy, with implementation and broader dissemination strategies part of its design from gestation. A defining feature of co-creation is its emergent and adaptive nature, making detailed pre-specification of interventions and outcome measures impossible. This methodology sits oddly with ethics committee protocols that require precise pre-definition of interventions, mode of delivery, outcome measurements, and the role of study participants. But the strict (and, some would say, inflexible) requirements of ethics committees were developed for a purpose - to protect participants from harm and help ensure the rigour and transparency of studies. We propose some guiding principles to help square this circle. First, ethics committees should acknowledge and celebrate the diversity of research approaches, both formally (through training) and informally (by promoting debate and discussion); without active support, their members may not understand or value participatory designs. Second, ground rules should be established for co-design applications (e.g. how to judge when 'consultation' or 'engagement' becomes research) and communicated to committee members and stakeholders. Third, the benefits of power-sharing should be recognised and credit given to measures likely to support this important goal, especially in research with

  2. Rational design of ABC triblock terpolymer solution nanostructures with controlled patch morphology

    Science.gov (United States)

    Löbling, Tina I.; Borisov, Oleg; Haataja, Johannes S.; Ikkala, Olli; Gröschel, André H.; Müller, Axel H. E.

    2016-06-01

    Block copolymers self-assemble into a variety of nanostructures that are relevant for science and technology. While the assembly of diblock copolymers is largely understood, predicting the solution assembly of triblock terpolymers remains challenging due to complex interplay of block/block and block/solvent interactions. Here we provide guidelines for the self-assembly of linear ABC triblock terpolymers into a large variety of multicompartment nanostructures with C corona and A/B cores. The ratio of block lengths NC/NA thereby controls micelle geometry to spheres, cylinders, bilayer sheets and vesicles. The insoluble blocks then microphase separate to core A and surface patch B, where NB controls the patch morphology to spherical, cylindrical, bicontinuous and lamellar. The independent control over both parameters allows constructing combinatorial libraries of unprecedented solution nanostructures, including spheres-on-cylinders/sheets/vesicles, cylinders-on-sheets/vesicles, and sheets/vesicles with bicontinuous or lamellar membrane morphology (patchy polymersomes). The derived parameters provide a logical toolbox towards complex self-assemblies for soft matter nanotechnologies.

  3. Rational design of solution additives for the prevention of protein aggregation.

    Science.gov (United States)

    Baynes, Brian M; Trout, Bernhardt L

    2004-09-01

    We have developed a statistical-mechanical model of the effect of solution additives on protein association reactions. This model incorporates solvent radial distribution functions obtained from all-atom molecular dynamics simulations of particular proteins into simple models of protein interactions. In this way, the effects of additives can be computed along the entire association/dissociation reaction coordinate. We used the model to test our hypothesis that a class of large solution additives, which we term "neutral crowders," can slow protein association and dissociation by being preferentially excluded from protein-protein encounter complexes, in a manner analogous to osmotic stress. The magnitude of this proposed "gap effect" was probed for two simple model systems: the association of two spheres and the association of two planes. Our results suggest that for a protein of 20 A radius, an 8 A additive can increase the free energy barrier for association and dissociation by as much as 3-6 kcal/mol. Because the proposed gap effect is present only for reactions involving multiple molecules, it can be exploited to develop novel additives that affect protein association reactions although having little or no effect on unimolecular reactions such as protein folding. This idea has many potential applications in areas such as the stabilization of proteins against aggregation during folding and in pharmaceutical formulations.

  4. Development of a Virtual Reality Solution for End User Involvement in Interior Design

    DEFF Research Database (Denmark)

    Svidt, Kjeld; Sørensen, Jesper Bendix

    2016-01-01

    This paper describes development and test of a prototype Virtual Reality system aimed at user involvement in hospital design. User needs and functional requirements are captured by interviews and observations in three case studies of ongoing projects in Denmark. Based on the identified requirements......, a prototype is developed based on a multitouch display for manipulating room layout in a floor plan view and a set of Oculus Rift glasses for experiencing the design in Virtual Reality. Together with users from the studied cases, test scenarios were performed to identify possible benefits, challenges...

  5. Development of a Virtual Reality Solution for End User Involvement in Interior Design

    DEFF Research Database (Denmark)

    Svidt, Kjeld; Sørensen, Jesper Bendix

    2016-01-01

    This paper describes development and test of a prototype Virtual Reality system aimed at user involvement in hospital design. User needs and functional requirements are captured by interviews and observations in three case studies of ongoing projects in Denmark. Based on the identified requirements......, a prototype is developed based on a multitouch display for manipulating room layout in a floor plan view and a set of Oculus Rift glasses for experiencing the design in Virtual Reality. Together with users from the studied cases, test scenarios were performed to identify possible benefits, challenges...

  6. Organizational factors in design and implementation of technological and organizational solutions in the nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    Macchi, L.; Reiman, T.; Savioja, P. (VTT Technical Research Centre of Finland (Finland)); Kahlbom, U. (Risk Pilot AB, Stockholm (Sweden)); Rollenhagen, C. (Vattenfall (Sweden))

    2012-03-15

    Design is often found as one of the contributing factors in accident in the nuclear industry. The design of new technological systems and organisational structures has to take into account and be driven by the future users' needs and has to consider how their role and work practices within the organisation will be affected. The SADE project explores to which extend the concepts of safety culture and resilience engineering can contribute to the prevention of design errors when no hindsight data are available. In 2011, the SADE project focused on gathering experience and clarifying the current issues and challenges related to the design process. During 2011 seventeen interviews have been conducted in Finland and Sweden to identify some of the major challenges the nuclear industry is currently facing. At the same time a literature review has been conducted to establish a sound common theoretical ground. This progress report presents some of the relevant theoretical findings and preliminary results from the interviews. (Author)

  7. A Design Based Research Framework for Implementing a Transnational Mobile and Blended Learning Solution

    Science.gov (United States)

    Palalas, Agnieszka; Berezin, Nicole; Gunawardena, Charlotte; Kramer, Gretchen

    2015-01-01

    The article proposes a modified Design-Based Research (DBR) framework which accommodates the various socio-cultural factors that emerged in the longitudinal PA-HELP research study at Central University College (CUC) in Ghana, Africa. A transnational team of stakeholders from Ghana, Canada, and the USA collaborated on the development,…

  8. Interaction design challenges and solutions for ALMA operations monitoring and control

    Science.gov (United States)

    Pietriga, Emmanuel; Cubaud, Pierre; Schwarz, Joseph; Primet, Romain; Schilling, Marcus; Barkats, Denis; Barrios, Emilio; Vila Vilaro, Baltasar

    2012-09-01

    The ALMA radio-telescope, currently under construction in northern Chile, is a very advanced instrument that presents numerous challenges. From a software perspective, one critical issue is the design of graphical user interfaces for operations monitoring and control that scale to the complexity of the system and to the massive amounts of data users are faced with. Early experience operating the telescope with only a few antennas has shown that conventional user interface technologies are not adequate in this context. They consume too much screen real-estate, require many unnecessary interactions to access relevant information, and fail to provide operators and astronomers with a clear mental map of the instrument. They increase extraneous cognitive load, impeding tasks that call for quick diagnosis and action. To address this challenge, the ALMA software division adopted a user-centered design approach. For the last two years, astronomers, operators, software engineers and human-computer interaction researchers have been involved in participatory design workshops, with the aim of designing better user interfaces based on state-of-the-art visualization techniques. This paper describes the process that led to the development of those interface components and to a proposal for the science and operations console setup: brainstorming sessions, rapid prototyping, joint implementation work involving software engineers and human-computer interaction researchers, feedback collection from a broader range of users, further iterations and testing.

  9. Graphic Design: A Sustainable Solution to Manage the Contents of Teaching Materials

    Science.gov (United States)

    Victor, Garcia Izaguirre; Luisa, Pier Castello Maria; Eduardo, Arvizu Sanchez

    2010-01-01

    There is a concern that the teaching of subjects is applied not only with support from a set of technological devices, but largely in the proper use of teaching and new technologies. Taking this idea, the authors develop a research and sustainable design that result in educational materials in solid content and technological innovation, also to…

  10. Solution of Algebraic Equations in the Analysis, Design, and Optimization of Continuous Ultrafiltration

    Science.gov (United States)

    Foley, Greg

    2011-01-01

    Continuous feed and bleed ultrafiltration, modeled with the gel polarization model for the limiting flux, is shown to provide a rich source of non-linear algebraic equations that can be readily solved using numerical and graphical techniques familiar to undergraduate students. We present a variety of numerical problems in the design, analysis, and…

  11. Participatory design of ehealth solutions for women from vulnerable populations with perinatal depression.

    Science.gov (United States)

    Gordon, Mara; Henderson, Rebecca; Holmes, John H; Wolters, Maria K; Bennett, Ian M

    2016-01-01

    Cultural and health service obstacles affect the quality of pregnancy care that women from vulnerable populations receive. Using a participatory design approach, the Stress in Pregnancy: Improving Results with Interactive Technology group developed specifications for a suite of eHealth applications to improve the quality of perinatal mental health care. We established a longitudinal participatory design group consisting of low-income women with a history of antenatal depression, their prenatal providers, mental health specialists, an app developer, and researchers. The group met 20 times over 24 months. Applications were designed using rapid prototyping. Meetings were documented using field notes. The group achieved high levels of continuity and engagement. Three apps were developed by the group: an app to support high-risk women after discharge from hospital, a screening tool for depression, and a patient decision aid for supporting treatment choice. Longitudinal participatory design groups are a promising, highly feasible approach to developing technology for underserved populations. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  12. The design of Smart Energy Systems for 100% renewable energy and transport solutions

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Connolly, David

    2013-01-01

    In this paper we launch the design of Smart Energy Systems through the 100% renewable energy system analyses and research behind the CEESA research project. The transition from fossil fuels towards the integration of more and more renewable energy requires rethinking and redesign of the energy...

  13. Towards appropriate design solutions for drug-resistant TB facilities in SA

    CSIR Research Space (South Africa)

    Parsons, SA

    2010-07-01

    Full Text Available South Africa has a high and increasing burden of both drugs-susceptible and drug-resistant tuberculosis. This disease has been declared an emergency in Africa. South Africa has committed itself to addressing this national crises by designing...

  14. Combining design-based research and action research to test management solutions

    NARCIS (Netherlands)

    Dr. Daan Andriessen

    2006-01-01

    This paper presents an approach to organizational research that aims to produce research results that are both relevant and rigorous. The research approach combines the designing of a management tool with the testing of the tool using an action research methodology. The lack of relevance in

  15. Research through design : A way to drive innovative solutions in the field of smart textiles

    NARCIS (Netherlands)

    Bottenberg, E. (Eliza); Brinks, G.J. (Ger); Toeters, M. (Marina)

    2012-01-01

    Research through design allows creating a dialogue with the material. It uses making andreflection on action as a generator of knowledge. Our aim is to explore the opportunities and challenges of smart textiles. The Fablab is our set up, a place that allows us to combine the hackingscientific-, and

  16. A Design Based Research Framework for Implementing a Transnational Mobile and Blended Learning Solution

    Science.gov (United States)

    Palalas, Agnieszka; Berezin, Nicole; Gunawardena, Charlotte; Kramer, Gretchen

    2015-01-01

    The article proposes a modified Design-Based Research (DBR) framework which accommodates the various socio-cultural factors that emerged in the longitudinal PA-HELP research study at Central University College (CUC) in Ghana, Africa. A transnational team of stakeholders from Ghana, Canada, and the USA collaborated on the development,…

  17. On alternating quantum walks

    Science.gov (United States)

    Rousseva, Jenia; Kovchegov, Yevgeniy

    2017-03-01

    We study an inhomogeneous quantum walk on a line that evolves according to alternating coins, each a rotation matrix. For the quantum walk with the coin alternating between clockwise and counterclockwise rotations by the same angle, we derive a closed form solution for the propagation of probabilities, and provide its asymptotic approximation via the method of stationary phase. Finally, we observe that for a x03c0;/4 angle, this alternating rotation walk will replicate the renown Hadamard walk.

  18. Analysis and design of machine learning techniques evolutionary solutions for regression, prediction, and control problems

    CERN Document Server

    Stalph, Patrick

    2014-01-01

    Manipulating or grasping objects seems like a trivial task for humans, as these are motor skills of everyday life. Nevertheless, motor skills are not easy to learn for humans and this is also an active research topic in robotics. However, most solutions are optimized for industrial applications and, thus, few are plausible explanations for human learning. The fundamental challenge, that motivates Patrick Stalph, originates from the cognitive science: How do humans learn their motor skills? The author makes a connection between robotics and cognitive sciences by analyzing motor skill learning using implementations that could be found in the human brain – at least to some extent. Therefore three suitable machine learning algorithms are selected – algorithms that are plausible from a cognitive viewpoint and feasible for the roboticist. The power and scalability of those algorithms is evaluated in theoretical simulations and more realistic scenarios with the iCub humanoid robot. Convincing results confirm the...

  19. Major Design Drivers for LEO Space Surveillance in Europe and Solution Concepts

    Science.gov (United States)

    Krag, Holger; Flohrer, Tim; Klinkrad, Heiner

    Europe is preparing for the development of an autonomous system for space situational aware-ness. One important segment of this new system will be dedicated to surveillance and tracking of space objects in Earth orbits. First concept and capability analysis studies have led to a draft system proposal. This proposal foresees, in a first deployment step, a groundbased system consisting of radar sensors and a network of optical telescopes. These sensors will be designed to have the capability of building up and maintaining a catalogue of space objects. A number of related services will be provided, including collision avoidance and the prediction of uncontrolled reentry events. Currently, the user requirements are consolidated, defining the different services, and the related accuracy and timeliness of the derived products. In this consolidation process parameters like the lower diameter limit above which catalogue coverage is to be achieved, the degree of population coverage in various orbital regions and the accuracy of the orbit data maintained in the catalogue are important design drivers for the selection of number and location of the sensors, and the definition of the required sensor performance. Further, the required minimum time for the detection of a manoeuvre, a newly launched object or a fragmentation event, significantly determines the required surveillance performance. In the requirement consolidation process the performance to be specified has to be based on a careful analysis which takes into account accuracy constraints of the services to be provided, the technical feasibility, complexity and costs. User requirements can thus not be defined with-out understanding the consequences they would pose on the system design. This paper will outline the design definition process for the surveillance and tracking segment of the European space situational awareness system. The paper will focus on the low-Earth orbits (LEO). It will present the core user

  20. Systematic network synthesis and design: Problem formulation, superstructure generation, data management and solution

    DEFF Research Database (Denmark)

    Quaglia, Alberto; Gargalo, Carina L.; Chairakwongsa, Siwanat;

    2015-01-01

    The developments obtained in recent years in the field of mathematical programming considerably reduced the computational time and resources needed to solve large and complex Mixed Integer Non Linear Programming (MINLP) problems. Nevertheless, the application of these methods in industrial practice...... when large problems are considered. In an earlier work, we proposed a computer-aided framework for synthesis and design of process networks. In this contribution, we expand the framework by including methods and tools developed to structure, automate and simplify the mathematical formulation...... is still limited by the complexity associated with the mathematical formulation of some problems. In particular, the tasks of design space definition and representation as superstructure, as well as the data collection, validation and handling may become too complex and cumbersome to execute, especially...

  1. Mission-constrained design drivers and technical solutions for the MAGIA satellite

    Science.gov (United States)

    Perrotta, Giorgio; Stipa, M.; Silvi, D.; Coltellacci, S.; Curti, G.; Colonna, G.; Formica, T.; Casali, V.; Fossati, T.; Di Matteo, F.; Zelli, M.; Rinaldi, M.; Ansalone, L.; di Salvo, A.

    2011-10-01

    The Mission MAGIA (Missione Altimetrica Geofisica GeochImica lunAre) was proposed in the framework of the "Bando per Piccole Missioni" of ASI (Italian Space Agency) in 2007. The mission was selected for a phase A study by ASI on February 7th 2008. The tight budget allocation, combined with quite ambitious scientific objectives, set challenging requirements for the satellite design. The paper gives a fast overview of the payloads complement and of the mission-constrained design drivers, including cost minimization, risk reduction, and AIT flexibility. The spacecraft architecture is then outlined, along with an overview of the key subsystems and trade-offs. Some details are given of a Moon gravitometric experiment based on a mother-daughter satellite configuration with the daughter being a subsatellite released from the MAGIA satellite and intended to circle the Moon at a very low altitude. Budgets are appended at the end of the paper showing the key study results.

  2. Impact of Energetic Management on the Development of LEVS as an Mode Alternative Transport Solutions Mobility to Urban/Metropolitan; Impacto de la Gestion Energetica sobre el Desarrollo de los LEVS como Modo de Transporte Alternativo en las Soluciones de Movilidad Urbana/Metropolitana

    Energy Technology Data Exchange (ETDEWEB)

    Fuentes, M.

    2011-05-13

    This work presents the study of the impact of energy and social management on the development of pedal assisted electric bikes as an alternative mode of personal transport in displacement of workers within the workplace and between their homes from/to the work, with the purpose of finding new solutions to urban/metropolitan mobility. Given the multidisciplinary nature of the project, designing a methodology that has focused on the achievement of five tasks covers the basic parameters of continuous improvement strategies, apply them throughout the project in three phases each of them centered in a specific mobility scenario urban/metropolitan setting the necessary interactions between the factors: physical, sociological and technical: Phase 1 (Mobility located in a workplace), Phase 2 (mobility between home and workplace) and Phase 3 (Integration of mobility pedal assisted electric bicycle in the context of public transportation). In addition, we introduce what we think may be two new alternatives to current mobility solutions posed environments: the design of a system of BIPA on demand for the internal displacement of a workplace and the system of mobility BIPA for displacement between a massive public transport node and the workplace. (Author) 32 refs.

  3. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    OpenAIRE

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD pr...

  4. [Alternate method for closure of oro-antral fistulas. Plastic covering of jaw opening with lyophilized Dura and alcoholic solution of Prolamin].

    Science.gov (United States)

    Kinner, U; Frenkel, G

    1990-11-01

    The operative closure of an oroantral fistula due to tooth extractions by the method of Rehrmann consists of various disadvantages, e.g. postoperative pain, swelling, flattening of the vestibulum and scar-tissue. Two alternative methods to close fresh oroantral fistulas without surgical intervention are described. By the use of prolamin occlusion gel or lyophilized dura these disadvantages can be avoided. Both techniques were successfully attempted on patients. The rate of failure is on both counts under 4%. Some indications limits must be strictly regarded. Both methods are really a good alternative to the usual operative procedure of Rehrmann and can easily be applied even on patients of great risk.

  5. PATENT SEARCH DESIGN PROVIDES TILLAGE OVERTURNING. METOD SEARCH. THE PROPOSED TECHNICAL SOLUTION

    Directory of Open Access Journals (Sweden)

    Belousov S. V.

    2015-04-01

    Full Text Available The article deals with the issue of patent search of mechanization for the main-processin you with a turnover of reservoir devices carry it out-ment, identified problems existing in the given-term technological operation. The ways of solving them and their implementation are shown. We describe two possible variants, making patent search using two search engines FIPS and FINDPATENT. We have shown the closest in design and type of patents that answer the main question which is tillage, the ways of influencing the process of improving tillage with a turnover of reservoir and definition of the design for further examination. This article has applied nature and is aimed at improving trend constructions of arable unit to improve the quality performance. We have proposed and presented a design of reversible ploughs and its body to moldboard tillage. When using a system of rational agriculture, we comply with all management practices of the application of modern energy-saving technology, the goal will be reached - increasing crop yields with less expenses

  6. Trends in Modelling, Simulation and Design of Water Hydraulic Systems – Motion Control and Open-Ended Solutions

    DEFF Research Database (Denmark)

    Conrad, Finn

    2006-01-01

    The paper presents and discusses a R&D-view on trends in development and best practise in modelling, simulation and design of both low-pressure and high-pressure tap water hydraulic components and systems for motion control as well as open-ended solutions various industrial applications. The focus...... is on the advantages using ordinary tap water and the range of application areas are illustrated with examples, in particular within the food processing industry, humidification operations, water mist systems for fire fighting, high water pressure cleaners, water moisturising systems for wood processing, lumber drying...... is that the components operate with pure water from the tap without additives of any kind. Hence water hydraulics takes the benefit of pure water as fluid being environmentally friendly, easy to clean sanitary design, non-toxic, non-flammable, inexpensive, readily available and easily disposable. The low-pressure tap...

  7. Design Solutions for the Treatment of DMSD in the ISS Water Recovery System

    Science.gov (United States)

    Perry, Jay; Carter, Donald; Kayatin, Matthew; Bowman, Elizabeth; Gentry, Greg; Muirhead, Brian; Gazda, Daniel; Wilson, Mark

    2017-01-01

    Dimethylsilanediol (DMSD) has been identified as a problematic organic on ISS. This contaminant was initially identified in the Water Processor Assembly (WPA) product water in 2010 by the Total Organic Carbon Analyzer (TOCA). DMSD is not a crew health hazard at the levels observed in the product water, but it may degrade the performance of the Oxygen Generation System (OGS) which uses the WPA product water for electrolysis and does impact the effective operation of the WPA catalytic reactor. To mitigate these impacts, early replacement of the Multifiltration Beds in the WPA is required. An investigation has determined that the decomposition of atmospheric polydimethylsiloxanes (PDMSs) is the primary source of DMSD in the condensate. PDMSs are prevalent on ISS from a variety of sources, including crew hygiene products, adhesives, caulks, lubricants, and various nonmetallics. These PDMSs also contribute to degradation of the CHX hydrophilic coating, rendering it hydrophobic and therefore affecting its ability to transmit water to the condensate bus. In addition, literature research has determined that PDMSs are likely oxidized to DMSD in the atmosphere when exposed to hydroxyl radicals in the ISS atmosphere. To address these mechanisms, filters have been developed for removal of PDMSs from the ISS atmosphere. However, ongoing analysis indicates a significant reduction in atmospheric PDMSs is required to achieve a measurable reduction of DMSD in the condensate. As a result, additional measures are being pursued to mitigate this issue. First, credible sources are being investigated to quantity to the extent possible the significant sources of PDMSs and identify sources that can be reasonably removed from ISS. Second, a Reverse Osmosis technology is being investigated as an alternate means for removing DMSD from the condensate. This paper summarizes the current status of the overall effort to mitigate DMSD in the US condensate.

  8. Designing solutions for the retirement system – in search of balance between economy and health

    Directory of Open Access Journals (Sweden)

    Piotr Romaniuk

    2016-08-01

    Full Text Available Social security system currently face a number of difficulties arising of changes in the demographic structure of societies, like the decrease in fertility, lengthening of life expectancy and unfavorable change in the proportion of the population receiving retirement benefits to the population in working age. In result social security systems are being subjects to transition aimed ad securing their financial stability, part of which is a tendency to rise the retirement age and eliminate all the incentives to prematurely exit the labor market. On the other hand, this process of transition, as observed in Poland, is being driven mainly by political processes and due to economic reasons, while lacking public health evidence. This rises a danger that in final result the financial savings will be illusory only, and that the final configuration of the system will be inconsistent with the actual social needs of the population and will not efficiently protect against the social risks. In the article we present arguments for using the Healthy Life Years indicator in analyzes relating to the performance of social security systems, so that its construction will reflect differences in health status of different professional groups and system’s solutions in terms of both risk protection and prevention might be adjusted to conditions characterizing these groups.

  9. Designing Solutions for the Retirement System - In Search of Balance between Economy and Health.

    Science.gov (United States)

    Romaniuk, Piotr; Brukało, Katarzyna

    2016-01-01

    Social security system currently faces a number of difficulties arising of changes in the demographic structure of societies, like the decrease in fertility, lengthening of life expectancy, and unfavorable change in the proportion of the population receiving retirement benefits to the population in working age. In result, social security systems are being subjected to transition aimed at securing their financial stability, part of which is a tendency to rise the retirement age and eliminate all the incentives to prematurely exit the labor market. On the other hand, this process of transition, as observed in Poland, is being driven mainly by political processes and due to economic reasons, while lacking public health evidence. This raises a danger that in final result the financial savings will be illusory only and that the final configuration of the system will be inconsistent with the actual social needs of the population and will not efficiently protect against the social risks. In this article, we present arguments for using the Healthy Life Years indicator in analyses relating to the performance of social security systems. The indicator may help to reflect differences in health status of different professional groups and adjust system's solutions to conditions characterizing these groups, in terms of both risk protection and prevention.

  10. Computational benefits using artificial intelligent methodologies for the solution of an environmental design problem: saltwater intrusion.

    Science.gov (United States)

    Papadopoulou, Maria P; Nikolos, Ioannis K; Karatzas, George P

    2010-01-01

    Artificial Neural Networks (ANNs) comprise a powerful tool to approximate the complicated behavior and response of physical systems allowing considerable reduction in computation time during time-consuming optimization runs. In this work, a Radial Basis Function Artificial Neural Network (RBFN) is combined with a Differential Evolution (DE) algorithm to solve a water resources management problem, using an optimization procedure. The objective of the optimization scheme is to cover the daily water demand on the coastal aquifer east of the city of Heraklion, Crete, without reducing the subsurface water quality due to seawater intrusion. The RBFN is utilized as an on-line surrogate model to approximate the behavior of the aquifer and to replace some of the costly evaluations of an accurate numerical simulation model which solves the subsurface water flow differential equations. The RBFN is used as a local approximation model in such a way as to maintain the robustness of the DE algorithm. The results of this procedure are compared to the corresponding results obtained by using the Simplex method and by using the DE procedure without the surrogate model. As it is demonstrated, the use of the surrogate model accelerates the convergence of the DE optimization procedure and additionally provides a better solution at the same number of exact evaluations, compared to the original DE algorithm.

  11. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here......, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD problems can be formulated and solved through this model....

  12. Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design

    DEFF Research Database (Denmark)

    Zhang, Lei; Cignitti, Stefano; Gani, Rafiqul

    2015-01-01

    This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here......, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD problems can be formulated and solved through this model....

  13. Alternative energies; Energies alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Bonal, J.; Rossetti, P

    2007-07-01

    The earth took millions years to made the petroleum, the gas the coal and the uranium. Only a few centuries will be needed to exhaust these fossil fuels and some years to reach expensive prices. Will the wold continue on this way of energy compulsive consumption? The renewable energies and some citizen attitudes are sufficient to break this spiral. This book proposes to discuss these alternative energies. It shows that this attitude must be supported by the government. It takes stock on the more recent information concerning the renewable energies. it develops three main points: the electricity storage, the housing and the transports. (A.L.B.)

  14. Customer Relationship Management System in Occupational Safety & Health Companies: Research on Practice and Preliminary Design Solution

    Directory of Open Access Journals (Sweden)

    Robert Fabac

    2011-10-01

    Full Text Available One of the most prominent contemporary trends in formation of companies is the approach to development of a customer-oriented company. In this matter, various versions related to the intensity of this orientation are differentiated. Customer relationship management (CRM system is a well-known concept, and its practice is being studied and improved in connection to various sectors. Companies providing services of occupational safety and health (OHS mainly cooperate with a large number of customers and the quality of this cooperation largely affects the occupational safety and health of employees. Therefore, it is of both scientific and wider social interest to study and improve the relationship of these companies with their customers. This paper investigates the practice of applying CRM in Croatian OHS companies. It identifies the existing conditions and suggests possible improvements in the practice of CRM, based on experts’ assessments using analytic hierarchy process evaluation. Universal preliminary design was created as a framework concept for the formation of a typical customer-oriented OHS services company. Preliminary design includes a structural view, which provides more details through system diagrams, and an illustration of main cooperation processes of a company with its customer.

  15. A rationally designed composite of alternating strata of Si nanoparticles and graphene: a high-performance lithium-ion battery anode.

    Science.gov (United States)

    Sun, Fu; Huang, Kai; Qi, Xiang; Gao, Tian; Liu, Yuping; Zou, Xianghua; Wei, Xiaolin; Zhong, Jianxin

    2013-09-21

    We have successfully fabricated a free-standing Si-re-G (reduced graphene) alternating stratum structure composite through a repeated process of filtering liquid exfoliated graphene oxide and uniformly dispersed Si solution, followed by the reduction of graphene oxide. The as-prepared free-standing flexible alternating stratum structure composite was directly evaluated as the anode for rechargeable lithium half-cells without adding any polymer binder, conductive additives or using current collectors. The half cells based on this new alternating structure composite exhibit an unexpected capacity of 1500 mA h g(-1) after 100 cycles at 1.35 A g(-1). Our rationally proposed strategy has incorporated the long cycle life of carbon and the high lithium-storage capacity of Si into one entity using the feasible and scalable vacuum filtration technique, rendering this new protocol as a readily applicable means of addressing the practical application challenges associated with the next generation of rechargeable lithium-ion batteries.

  16. Analytical Solution for Interference Fit for Multi-Layer Thick-Walled Cylinders and the Application in Crankshaft Bearing Design

    Directory of Open Access Journals (Sweden)

    Jun Qiu

    2016-06-01

    Full Text Available Interference fit is an important contact mode used for torque transmission existing widely in engineering design. To prevent trackslip, a certain magnitude of interference has to be ensured; meanwhile, the interference needs to be controlled to avoid failure of the mechanical components caused by high assembly stress. The finite element method (FEM can be used to analyze the stress, while the computational cost of FEM involving nonlinear contact algorithm is relatively high, and likely to come across low precision and convergence problems. Therefore, a rapid and accurate analytical method for estimation is of vital need, especially for the initial design stage when the parameters vary in a large range. In this study, an analytical method to calculate the contact pressure and stress between multi-layer thick-walled cylinders (MLTWC with multi-contact pairs and temperature-raising effect is proposed, and evaluated by FEM. The analytical solution of the interference for tri-layer thick-walled cylinders is applied to the design of engine crankshaft bearing. The results indicate that the analytical method presented in this study can reduce complexity of MLTWC problems and improve the computational efficiency. It is well suited to be used for the calculation model of parameter optimization in early design.

  17. Artisanal fishing net float loss and a proposal for a float design solution

    Directory of Open Access Journals (Sweden)

    Paulo de Tarso Chaves

    2016-03-01

    Full Text Available Abstract Plastic floats from fishing nets are commonly found washed up on beaches in southern Brazil. They are usually broken and show signs of having been repaired. Characteristics of floats and interviews with fishermen suggest two main causes of float loss. First, collisions between active gear, bottom trawl nets for shrimp, and passive gear, drift nets for fish, destroy nets and release fragments of them, including floats. Second, the difficulty with which floats are inserted on the float rope of the nets when they are used near the surface. Floats are inserted to replace damaged or lost floats, or they may be removed if it is desired that the nets be used in deeper waters. Floats may thus be poorly fixed to the cables and lost. Here a new float design that offers greater safety in use and for the replacement of floats is described and tested.

  18. Problems and solutions in high-rate multichannel hybrid photodiode design The CMS experience

    CERN Document Server

    Cushman, P B

    2002-01-01

    The unique conditions of the CMS experiment (4 T magnetic field, restricted access, high neutron radiation, and 25-ns bunch-crossings) necessitated the development of a new type of high-rate multichannel hybrid photodiode for the tile/fiber hadronic calorimeter. New complexities arose in the push toward high-rate operation, necessitating design changes in the diode structure and surface treatment. The product is now capable of high-rate operation with low crosstalk and leakage current. Lifetime studies of high-voltage behavior, total charge, and irradiation have shown that the tubes will survive the ten years of CMS running with only a few percent change in gain and manageable leakage current rise. (13 refs).

  19. Fully Decoupled Compliant Parallel Mechanism: a New Solution for the Design of Multidimensional Accelerometer

    Directory of Open Access Journals (Sweden)

    Zhen GAO

    2010-08-01

    Full Text Available In this paper, a novel multidimensional accelerometer is proposed based on fully decoupled compliant parallel mechanism. Three separated chains, which are served as the elastic body, are perpendicular to each other for sensing the kinetic information in different directions without decoupling process. As the crucial part of the whole sensor structure, the revolute and prismatic joints in three pairwise orthogonal branches of the parallel mechanism are manufactured with the alloy aluminium as flexure hinge-based compliant joints. The structure development is first introduced, followed by the comprehensive finite-element analysis including the strain of the sensitive legs, modal analysis for total deformation under different frequency, and the performance of harmonic response. Then, the shape optimization is conducted to reduce the unnecessary parts. Compliance optimization with particle swarm algorithm is implemented to redesign the dimension of the sensitive legs. The research supplies a new viewpoint for the mechanical design of physical sensor, especially acceleration sensor.

  20. Point-of-care solution for osteoporosis management design, fabrication, and validation of new technology

    CERN Document Server

    Khashayar, Patricia

    2017-01-01

    This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians.

  1. Designing Illumination Lenses and Mirrors by the Numerical Solution of Monge-Amp\\`ere Equations

    CERN Document Server

    Brix, Kolja; Platen, Andreas

    2015-01-01

    We consider the inverse refractor and the inverse reflector problem. The task is to design a free-form lens or a free-form mirror that, when illuminated by a point light source, produces a given illumination pattern on a target. Both problems can be modeled by strongly nonlinear second-order partial differential equations of Monge-Amp\\`ere type. In [Math. Models Methods Appl. Sci. 25 (2015), pp. 803--837, DOI: 10.1142/S0218202515500190] the authors have proposed a B-spline collocation method which has been applied to the inverse reflector problem. Now this approach is extended to the inverse refractor problem. We explain in depth the collocation method and how to handle boundary conditions and constraints. The paper concludes with numerical results of refracting and reflecting optical surfaces and their verification via ray tracing.

  2. Designing local solutions for emptying pit latrines in low-income urban settlements (Malawi)

    Science.gov (United States)

    Chipeta, W. C.; Holm, R. H.; Kamanula, J. F.; Mtonga, W. E.; de los Reyes, F. L.

    2017-08-01

    A lack of effective options in local technology poses challenges when onsite household sanitation facilities are eventually filled to capacity in unplanned settlement areas within Mzuzu City, located in northern Malawi. Vacuum trucks currently dominate the market but focus on emptying septic tanks in the more easily accessible planned settlement areas, rather than servicing the pit latrines common in unplanned settlement areas. As a result, households in the unplanned settlement areas within Mzuzu rely primarily on manual pit emptying (i.e., shoveling by hand) or digging a new pit latrine. These practices have associated health risks and are limited by space constraints. This research focused on filling the technological gap through the design, development, and testing of a pedal powered modified Gulper pump using locally available materials and fabrication. A modified pedal powered Gulper technology was developed and demonstrated to be capable of lifting fecal sludge from a depth of 1.5 m with a mean flow rate of 0.00058 m3/s. If the trash content was low, a typical pit latrine with a volume of 1-4 m3 could be emptied within 1-2 h. Based on the findings in our research Phase IV, the pedal powered Gulper modification is promising as a potential emptying technology for lined pit latrines in unplanned settlement areas. The success rate of the technology is about 17% (5 out 30 sampled lined pit latrines were successful) and reflects the difficulty in finding a single technology that can work well in all types of pit latrines with varying contents. We note that cost should not be the only design criteria and acknowledge the challenge of handling trash in pit latrines.

  3. The Evaluation and Testing of Various Bladeless Wind Turbine Designs for use as an alternative renewable energy source

    Science.gov (United States)

    Agnew, Ian; Ray, Taylor

    2014-03-01

    Over the last two decades wind turbines have proven themselves globally as a reliable, renewable, and clean energy source. Even though wind turbines are simpler in design and do not pollute during operation as compared to conventional energy sources, many improvements can still be made. The design of a bladeless wind turbine offers potential improvements such as cost savings, reduction of operating noise level, simplification of the manufacturing process, reduction of maintenance costs, and incorporation of eco-friendly features. In order to analyze various turbine designs, a wind tunnel with a 30.3 cm x 29.1 cm test section was constructed at Georgia College. Several different wing sections are being evaluated in order to determine the turbine design and engineered for optimal aerodynamic efficiency over a Range of Reynolds numbers. Other factors like Pressure coefficients and overall drag profile of the designs will also be analyzed as well.

  4. The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals

    DEFF Research Database (Denmark)

    van der Burg, Bart; Wedebye, Eva Bay; Dietrich, Daniel R.

    2015-01-01

    There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use. The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner preferably using validated existing tools and place them in an innovative alternative testing...... in vitro and in vivo exposure levels greatly improved predictivity of the in vitro tests. As a further step, we have generated examples how to predict reproductive toxicity of chemicals using available data. We have executed formal validations of panel constituents and also used more innovative manners...

  5. Alternative additives; Alternative additiver

    Energy Technology Data Exchange (ETDEWEB)

    2007-08-15

    In this project a number of industrial and agricultural waste products have been characterised and evaluated in terms of alkali-getter performance. The intended use is for biomass-fired power stations aiming at reducing corrosion or slagging related problems. The following products have been obtained, characterised and evaluated: 1) Brewery draff 2) Danish de-gassed manure 3) Paper sludge 4) Moulding sand 5) Spent bleaching earth 6) Anorthosite 7) Sand 8) Clay-sludge. Most of the above alternative additive candidates are deemed unsuitable due to insufficient chemical effect and/or expensive requirements for pre-treatment (such as drying and transportation). 3 products were selected for full-scale testing: de-gassed manure, spent bleaching earth and clay slugde. The full scale tests were undertaken at the biomass-fired power stations in Koege, Slagelse and Ensted. Spent bleaching earth (SBE) and clay sludge were the only tested additive candidates that had a proven ability to react with KCl, to thereby reduce Cl-concentrations in deposits, and reduce the deposit flux to superheater tubes. Their performance was shown to nearly as good as commercial additives. De-gassed manure, however, did not evaluate positively due to inhibiting effects of Ca in the manure. Furthermore, de-gassed manure has a high concentration of heavy metals, which imposes a financial burden with regard to proper disposal of the ash by-products. Clay-sludge is a wet clay slurring, and drying and transportation of this product entails substantial costs. Spent bleaching does not require much pre-treatment and is therefore the most promising alternative additive. On the other hand, bleaching earth contains residual plant oil which means that a range of legislation relating to waste combustion comes into play. Not least a waste combustion fee of 330 DKK/tonne. For all alternative (and commercial) additives disposal costs of the increase ash by-products represents a significant cost. This is

  6. Exploration of a capability-focused aerospace system of systems architecture alternative with bilayer design space, based on RST-SOM algorithmic methods.

    Science.gov (United States)

    Li, Zhifei; Qin, Dongliang; Yang, Feng

    2014-01-01

    In defense related programs, the use of capability-based analysis, design, and acquisition has been significant. In order to confront one of the most challenging features of a huge design space in capability based analysis (CBA), a literature review of design space exploration was first examined. Then, in the process of an aerospace system of systems design space exploration, a bilayer mapping method was put forward, based on the existing experimental and operating data. Finally, the feasibility of the foregoing approach was demonstrated with an illustrative example. With the data mining RST (rough sets theory) and SOM (self-organized mapping) techniques, the alternative to the aerospace system of systems architecture was mapping from P-space (performance space) to C-space (configuration space), and then from C-space to D-space (design space), respectively. Ultimately, the performance space was mapped to the design space, which completed the exploration and preliminary reduction of the entire design space. This method provides a computational analysis and implementation scheme for large-scale simulation.

  7. Deformability of plastering compositions in design solutions of modern thermal protective exterior walls

    Directory of Open Access Journals (Sweden)

    R.R. Vakhitov

    2013-04-01

    Full Text Available In recent years, appearance of new constructive decisions for multilayer thermal efficient walls in the practice of design and construction caused the increasing use of protective and decorative plaster compositions. Comprehensive protective plaster systems nowadays are used in the facade insulation systems as a protective layer on the surface of polystyrene foam or mineral wool boards, forming the insulating layer to the outer walls of concrete blocks. They are also used for exterior finish of walls made of gas-concrete blocks, plastering the brickwork of the buildings operated by rehabilitation, in particular, apartment houses of old mass series. The problem of ensuring durability of thermal efficient external walls with the use of protective and decorative plaster systems were identified in this article. The factors, affecting the resistance of facade plasters to the action of external conditions in operating process were considered. The weaknesses in the necessary characteristics of plaster mixtures provided by material manufacturers are revealed. The existing methods for determining crack resistance of plaster compositions are monitored. The author's method of determining the maximum stretch of plaster compositions is given. The article presents tests results of various plaster compositions, confirming the effectiveness of the proposed method.

  8. BILEVEL PROGRAMMING MODEL AND SOLUTION METHOD FOR MIXED TRANSPORTATION NETWORK DESIGN PROBLEM

    Institute of Scientific and Technical Information of China (English)

    Haozhi ZHANG; Ziyou GAO

    2009-01-01

    By handling the travel cost function artfully, the authors formulate the transportation mixed network design problem (MNDP) as a mixed-integer, nonlinear bilevel programming problem, in which the lower-level problem, comparing with that of conventional bilevel DNDP models, is not a side constrained user equilibrium assignment problem, but a standard user equilibrium assignment problem. Then, the bilevel programming model for MNDP is reformulated as a continuous version of bilevel programming problem by the continuation method. By virtue of the optimal-value function, the lower-level assignment problem can be expressed as a nonlinear equality constraint. Therefore, the bilevel programming model for MNDP can be transformed into an equivalent single-level optimization problem. By exploring the inherent nature of the MNDP, the optimal-value function for the lower-level equilibrium assignment problem is proved to be continuously differentiable and its functional value and gradient can be obtained efficiently. Thus, a continuously differentiable but still nonconvex optimization formulation of the MNDP is created, and then a locally convergent algorithm is proposed by applying penalty function method. The inner loop of solving the subproblem is mainly to implement an all-or-nothing assignment. Finally, a small-scale transportation network and a large-scale network are presented to verify the proposed model and algorithm.

  9. Generalized solution of design optimization and failure analysis of composite drive shaft

    Energy Technology Data Exchange (ETDEWEB)

    Kollipalli, K.; Shivaramakrishna, K.V.S.; Prabhakaran, R.T.D. [Birla Institute of Technology and Science, Goa (India)

    2012-07-01

    Composites have an edge over conventional metals like steel and aluminum due to higher stiffness-to-weight ratio and strength-to-weight ratio. Due to these advantages, composites can bring out a revolutionary change in materials used in automotive engineering, as weight savings has positive impacts on other attributes like fuel economy and possible noise, vibration and harshness (NVH). In this paper, the drive line system of an automotive system is targeted for use of composites by keeping constraints in view such as such as torque transmission, torsional buckling load and fundamental natural frequency. Composite drive shafts made of three different composites ('HM Carbon/HS Carbon/E-glass'-epoxy) was modeled using Catia V5R16 CPD workbench and a finite element analysis with boundary conditions, fiber orientation and stacking sequence was performed using ANSYS Composite module. Results obtained were compared to theoretical results and were found to be accurate and in the limits. This paper also speaks on drive shaft modeling and analysis generalization i.e., changes in stacking sequence in the future can be incorporated directly into ANSYS model without modeling it again in Catia. Hence the base model and analysis method made up in this analysis generalization facilitated by CAD/CAE can be used to carry out any composite shaft design optimization process. (Author)

  10. Design and implementation of disaster recovery and business continuity solution for radiology PACS.

    Science.gov (United States)

    Mansoori, Bahar; Rosipko, Beverly; Erhard, Karen K; Sunshine, Jeffrey L

    2014-02-01

    In the digital era of radiology, picture archiving and communication system (PACS) has a pivotal role in retrieving and storing the images. Integration of PACS with all the health care information systems e.g., health information system, radiology information system, and electronic medical record has greatly improved access to patient data at anytime and anywhere throughout the entire enterprise. In such an integrated setting, seamless operation depends critically on maintaining data integrity and continuous access for all. Any failure in hardware or software could interrupt the workflow or data and consequently, would risk serious impact to patient care. Thus, any large-scale PACS now have an indispensable requirement to include deployment of a disaster recovery plan to ensure secure sources of data. This paper presents our experience with designing and implementing a disaster recovery and business continuity plan. The selected architecture with two servers in each site (local and disaster recovery (DR) site) provides four different scenarios to continue running and maintain end user service. The implemented DR at University Hospitals Health System now permits continuous access to the PACS application and its contained images for radiologists, other clinicians, and patients alike.

  11. An Electronic Tongue Designed to Detect Ammonium Nitrate in Aqueous Solutions

    Directory of Open Access Journals (Sweden)

    Inmaculada Campos

    2013-10-01

    Full Text Available An electronic tongue has been developed to monitor the presence of ammonium nitrate in water. It is based on pulse voltammetry and consists of an array of eight working electrodes (Au; Pt; Rh; Ir; Cu; Co; Ag and Ni encapsulated in a stainless steel cylinder. In a first step the electrochemical response of the different electrodes was studied in the presence of ammonium nitrate in water in order to further design the wave form used in the voltammetric tongue. The response of the electronic tongue was then tested in the presence of a set of 15 common inorganic salts; i.e.; NH4NO3; MgSO4; NH4Cl; NaCl; Na2CO3; (NH42SO4; MgCl2; Na3PO4; K2SO4; K2CO3; CaCl2; NaH2PO4; KCl; NaNO3; K2HPO4. A PCA plot showed a fairly good discrimination between ammonium nitrate and the remaining salts studied. In addition Fuzzy Art map analyses determined that the best classification was obtained using the Pt; Co; Cu and Ni electrodes. Moreover; PLS regression allowed the creation of a model to correlate the voltammetric response of the electrodes with concentrations of ammonium nitrate in the presence of potential interferents such as ammonium chloride and sodium nitrate.

  12. Climate Change, Coastal Vulnerability and the Need for Adaptation Alternatives: Planning and Design Examples from Egypt and the USA

    OpenAIRE

    S Jeffress Williams; Nabil Ismail

    2015-01-01

    Planning and design of coastal protection for high-risk events with low to moderate or uncertain probabilities are a challenging balance of short- and long-term cost vs. protection of lives and infrastructure. The pervasive, complex, and accelerating impacts of climate change on coastal areas, including sea-level rise, storm surge and tidal flooding, require full integration of the latest science into strategic plans and engineering designs. While the impacts of changes occurring are global, ...

  13. Alternation of generations and experimental design: a guided-inquiry lab exploring the nature of the her1 developmental mutant of Ceratopteris richardii (C-Fern).

    Science.gov (United States)

    Spiro, Mark D; Knisely, Karin I

    2008-01-01

    Inquiry-based labs have been shown to greatly increase student participation and learning within the biological sciences. One challenge is to develop effective lab exercises within the constraints of large introductory labs. We have designed a lab for first-year biology majors to address two primary goals: to provide effective learning of the unique aspects of the plant life cycle and to gain a practical knowledge of experimental design. An additional goal was to engage students regardless of their biology background. In our experience, plant biology, and the plant life cycle in particular, present a pedagogical challenge because of negative student attitudes and lack of experience with this topic. This lab uses the fern Ceratopteris richardii (C-Fern), a model system for teaching and research that is particularly useful for illustrating alternation of generations. This lab does not simply present the stages of the life cycle; it also uses knowledge of alternation of generations as a starting point for characterizing the her1 mutation that affects gametophyte sexual development. Students develop hypotheses, arrive at an appropriate experimental design, and carry out a guided inquiry on the mechanism underlying the her1 mutation. Quantitative assessment of student learning and attitudes demonstrate that this lab achieves the desired goals.

  14. Future high school teachers' difficulties and alternatives found to planning electromagnetism activities designed for visual handicapped students

    Directory of Open Access Journals (Sweden)

    Eder Pires de Camargo

    2007-03-01

    Full Text Available We report here partial outcomes of a study aimed to verify future High School teachers' performance when, during the development of a called "Teaching Practice" undergraduate course, were asked to plan, elaborate and teach, in classroom situations, electromagnetism topics to a students class which included visual handicapped pupils. Data analyzed show that the main difficulties presented by the future Physics High School teachers are related to the approach to know physics phenomena as dependent of vision and to break with some elements of the traditional pedagogy. By other hand, as alternatives, future teachers showed creativity in order to surpass passive aptitudes related to this educational problem, working out methodological strategies deprived of the relation knowing/seeing, as well as, the work with orality in a physics education context.

  15. Design and Implementation of a Novel HomePlug-Based Solution for Low Cost and High Performance Smart Home Networking

    Institute of Scientific and Technical Information of China (English)

    S.M.T.Bathaee; A.Fereidunian; A.Khajeh Amiri Hagh; H.Heydari

    2014-01-01

    As the smart home is the end-point power consumer, it is the major part to be controlled in a smart micro grid. There are so many challenges for implementing a smart home system in which the most important ones are the cost and simplicity of the implementation method. It is clear that the major share of the total cost is referred to the internal controlling system network; although there are too many methods proposed but still there is not any satisfying method at the consumers’ point of view. In this paper, a novel solution for this demand is proposed, which not only minimizes the implementation cost, but also provides a high level of reliability and simplicity of operation;feasibility, extendibility, and flexibility are other leading properties of the design.

  16. Gender and cleaner production: toward a framework for including gender analysis when developing strategies and designing solutions.

    Science.gov (United States)

    Edwards, Sally; Quinn, Margaret

    2005-01-01

    Environmental policies that do not consider global gender dimensions often create benefits for some people and ecosystems but result in costs for others, in particular women, at some point along the global chain of production and consumption. This article is intended to begin a dialogue about the importance of including gender analysis in the design of cleaner production strategies. We review global development policy and its critiques that have identified a need for gender awareness and analysis. This examination provides a backdrop for a discussion of how to include gender analysis in cleaner production planning and implementation. We invite researchers and practitioners to enter this dialogue to further the field and develop effective tools and policies to analyze gender dynamics, support gender equity, and find environmentally sound solutions that are sustainable for the long-term.

  17. LINQifying TheBeerHouse An N-Tier LINQ Web Application with ASPNET 20 Website Programming Problem - Design - Solution

    CERN Document Server

    Dumond, Lee

    2008-01-01

    Finally, TheBeerHouse website from ASP.NET 2.0 Website Programming: Problem-Design-Solution gets the ASP.NET 3.5 treatment! This Wrox Blox presents two unique approaches to applying LINQ to SQL to data access in TheBeerHouse.   In Part 1, you'll take advantage of the original application's data provider model to develop a custom LINQ to SQL provider for the Articles module. In Part 2, you'll try a different approach, while learning how to develop an ASP.NET 3.5 application using a purely LINQ-based three-tier model. Along the way, you'll learn about LINQ to Objects; the newest features of the

  18. EVALUATION OF TECHNOLOGICAL SOLUTIONS FOR THE DESIGN AND DEVELOPMENT OF HEAVY OIL AND BITUMEN FIELDS IN NIGERIA

    Directory of Open Access Journals (Sweden)

    Nwizug-bee L. K.

    2016-06-01

    Full Text Available In Nigeria, belt of bituminous sand stretches to the East of Ijebu-Ode (Ogun State in the district of Siluko and Akotogbo, Okitipupa (Ondo Sate and Edo State. It covers a distance of approximately 110 km and lies in the upper cretaceous sequence of the Abeokuta formation in the eastern Dahomey Basin. Reserves of bituminous sand in Nigeria is estimated to be around 30- 40 billion barrels with a possibility to extract 3654 × 106 barrels. From the approximately 30-40 billion barrels of oil sand, Ogun State has more than 40% in reserve. However, this huge stock of oil sand in Nigeria is yet to be exploited. This article provides an assessment of technological solutions for the design and development of tar sand fields in Nigeria. Reserves of oil sand in Nigeria are the biggest in the whole of Africa

  19. The increase of surface area of a Brazilian palygorskite clay activated with sulfuric acid solutions using a factorial design

    Directory of Open Access Journals (Sweden)

    R. N. Oliveira

    2013-01-01

    Full Text Available Palygorskite is fibrous clay in which the structural tetrahedral and octahedral layers are organized in a way that structural channels are formed, leading to high surface area. However, impurities inside the channels and aggregated ones considerably reduce the available area. In order to increase the surface area, an activation treatment can be considered useful. The goal of this work is the activation of palygorskite from Guadalupe, Piauí, via sulfuric acid treatment using a two-level factorial design. The influence of three parameters (solution molarity, temperature and time on BET surface area was determined. Moreover, samples were characterized via X-ray diffraction (XRD and fluorescence (XRF, Fourier-transform infrared spectroscopy (FTIR and transmission electron microscopy (TEM. The largest surface area (282 m²/g without considerable changes in clay structure and morphology was found in a sample treated with 5M H2SO4 at 70°C for 1h. The main parameters that favored the improvement of the surface area were the solution's molarity, temperature and their interaction.

  20. CIRCUIT-DESIGN SOLUTIONS AND INFORMATION SUPPORT OF CITY ELECTRIC NETWORKS IN THE CONDITIONS OF THE SMART GRID

    Directory of Open Access Journals (Sweden)

    M. I. Fursanov

    2017-01-01

    Full Text Available The structure, circuit-design solutions and information support of the city electric networks in the conditions of the SMART GRID have been analyzed. It is demonstrated that the new conditions of functioning of electric power engineering, increasing demands for its technological state and reliability in most countries determined the transition to a restructuring of electrical networks to be based on the SMART GRID (intelligent power networks innovative new structure. The definitions of the SMART GRID, its various attributes and characteristics in most developed countries including Belarus are presented. It is revealed that the existing and future circuit and constructive solutions that can automate the process of managing modes of urban electric networks under the SMART GRID conditions are manifold. At present, the most common in distribution networks are the sources of distributed generation (combustion turbines, wind turbines, photovoltaic installations, mini-hydro, etc.. The patterns and problems of information traceability of a traditional urban networks of the unified energy system of Belarus have been analyzed, and it is demonstrated that in the conditions of the SMART GRID most of the problems of the control mode that are characteristic for traditional distribution networks 6–10 kV and 0.38 kV, lose their relevance. Therefore, the present article presents and features the main directions of development of automatic control modes of the SMART GRID.

  1. Solution-based synthesis and design of late transition metal chalcogenide materials for oxygen reduction reaction (ORR).

    Science.gov (United States)

    Gao, Min-Rui; Jiang, Jun; Yu, Shu-Hong

    2012-01-09

    Late transition metal chalcogenide (LTMC) nanomaterials have been introduced as a promising Pt-free oxygen reduction reaction (ORR) electrocatalysts because of their low cost, good ORR activity, high methanol tolerance, and facile synthesis. Herein, an overview on the design and synthesis of LTMC nanomaterials by solution-based strategies is presented along with their ORR performances. Current solution-based synthetic approaches towards LTMC nanomaterials include a hydrothermal/solvothermal approach, single-source precursor approach, hot-injection approach, template-directed soft synthesis, and Kirkendall-effect-induced soft synthesis. Although the ORR activity and stability of LTMC nanomaterials are still far from what is needed for practical fuel-cell applications, much enhanced electrocatalytic performance can be expected. Recent advances have emphasized that decorating the surface of the LTMC nanostructures with other functional nanoparticles can lead to much better ORR catalytic activity. It is believed that new synthesis approaches to LTMCs, modification techniques of LTMCs, and LTMCs with desirable morphology, size, composition, and structures are expected to be developed in the future to satisfy the requirements of commercial fuel cells.

  2. Human factors in design modifications: panel alternative stop in Almaraz; Factores humanos en modificaciones de diseno: panel deparada alternativa en CN Almaraz

    Energy Technology Data Exchange (ETDEWEB)

    Roman, Y.; Bote, J.

    2015-07-01

    Human Factors Engineering has acquired a crucial role in the development of any design modification (DM), where every aspect relative to any interaction with the human user has to be taken into account at any stage thereof. Considering this, during the last years, Almaraz Nuclear Powe Plants has developed a program of Human Factors Engineering in order to reach the internationally recognized standards or systematic collected on NUREG 0711 Human Factors Engineering Program Review Model (NRC). One of the most important projects of this program at Almaraz Nuclear Power Plant has been the implementation of the Alternative Stop Panel and their corresponding Transfer Panels. (Author)

  3. Solving Real World Problems with Alternate Reality Gaming: Student Experiences in the Global Village Playground Capstone Course Design

    Science.gov (United States)

    Dondlinger, Mary Jo; McLeod, Julie K.

    2015-01-01

    The Global Village Playground (GVP) was a capstone learning experience designed to address institutional assessment needs while providing an integrated and authentic learning experience for students aimed at fostering complex problem solving, as well as critical and creative thinking. In the GVP, students work on simulated and real-world problems…

  4. Structural similarity between binding sites in influenza sialidase and isocitrate dehydrogenase: implications for an alternative approach to rational drug design.

    OpenAIRE

    Poirrette, A. R.; Artymiuk, P. J.; Grindley, H. M.; Rice, D.W.; Willett, P.

    1994-01-01

    Using searching techniques based on algorithms derived from graph theory, we have established a similarity between a 3-dimensional cluster of side chains implicated in drug binding in influenza sialidase and side chains involved in isocitrate binding in Escherichia coli isocitrate dehydrogenase. The possible implications of the use of such comparative methods in drug design are discussed.

  5. Designing augmentative and alternative communication applications: the results of focus groups with speech-language pathologists and parents of children with autism spectrum disorder.

    Science.gov (United States)

    Boster, Jamie B; McCarthy, John W

    2017-05-10

    The purpose of this study was to gain insight from speech-language pathologists (SLPs) and parents of children with autism spectrum disorder (ASD) regarding appealing features of augmentative and alternative communication (AAC) applications. Two separate 1-hour focus groups were conducted with 8 SLPs and 5 parents of children with ASD to identify appealing design features of AAC Apps, their benefits and potential concerns. Participants were shown novel interface designs for communication mode, play mode and incentive systems. Participants responded to poll questions and provided benefits and drawbacks of the features as part of structured discussion. SLPs and parents identified a range of appealing features in communication mode (customization, animation and colour-coding) as well as in play mode (games and videos). SLPs preferred interfaces that supported motor planning and instruction while parents preferred those features such as character assistants that would appeal to their child. Overall SLPs and parents agreed on features for future AAC Apps. SLPs and parents have valuable input in regards to future AAC app design informed by their experiences with children with ASD. Both groups are key stakeholders in the design process and should be included in future design and research endeavors. Implications for Rehabilitation AAC applications for the iPad are often designed based on previous devices without consideration of new features. Ensuring the design of new interfaces are appealing and beneficial for children with ASD can potentially further support their communication. This study demonstrates how key stakeholders in AAC including speech language pathologists and parents can provide information to support the development of future AAC interface designs. Key stakeholders may be an untapped resource in the development of future AAC interfaces for children with ASD.

  6. Kinetic modeling of the biosorption of Cd2+ ions from aqueous solutions onto Eichhornia crassipes roots using potentiometry: low-cost alternative to conventional methods

    Directory of Open Access Journals (Sweden)

    Carolina Martínez-Sánchez

    2013-01-01

    Full Text Available This work presents the use of potentiometric measurements for kinetic studies of biosorption of Cd2+ ions from aqueous solutions on Eichhornia crassipes roots. The open circuit potential of the Cd/Cd2+ electrode of the first kind was measured during the bioadsorption process. The amount of Cd2+ ions accumulated was determined in real time. The data were fit to different models, with the pseudo-second-order model proving to be the best in describing the data. The advantages and limitations of the methodology proposed relative to the traditional method are discussed.

  7. The ChemScreen project to design a pragmatic alternative approach to predict reproductive toxicity of chemicals.

    Science.gov (United States)

    van der Burg, Bart; Wedebye, Eva Bay; Dietrich, Daniel R; Jaworska, Joanna; Mangelsdorf, Inge; Paune, Eduard; Schwarz, Michael; Piersma, Aldert H; Kroese, E Dinant

    2015-08-01

    There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use. The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner preferably using validated existing tools and place them in an innovative alternative testing strategy. In our approach we combined knowledge on critical processes affected by reproductive toxicants with knowledge on the mechanistic basis of such effects. We used in silico methods for prescreening chemicals for relevant toxic effects aiming at reduced testing needs. For those chemicals that need testing we have set up an in vitro screening panel that includes mechanistic high throughput methods and lower throughput assays that measure more integrative endpoints. In silico pharmacokinetic modules were developed for rapid exposure predictions via diverse exposure routes. These modules to match in vitro and in vivo exposure levels greatly improved predictivity of the in vitro tests. As a further step, we have generated examples how to predict reproductive toxicity of chemicals using available data. We have executed formal validations of panel constituents and also used more innovative manners to validate the test panel using mechanistic approaches. We are actively engaged in promoting regulatory acceptance of the tools developed as an essential step towards practical application, including case studies for read-across purposes. With this approach, a significant saving in animal use and associated costs seems very feasible. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. An alternative laboratory designed to address ethical concerns associated with traditional TAS2R38 student genotyping.

    Science.gov (United States)

    LaBonte, Michelle L; Beers, Melissa A

    2015-01-01

    The TAS2R38 alleles that code for the PAV/AVI T2R38 proteins have long been viewed as benign taste receptor variants. However, recent studies have demonstrated an expanding and medically relevant role for TAS2R38. The AVI variant of T2R38 is associated with an increased risk of both colorectal cancer and Pseudomonas aeruginosa-associated sinus infection and T2R38 variants have been implicated in off-target drug responses. To address ethical concerns associated with continued student TAS2R38 gene testing, we developed an alternative to the traditional laboratory genotyping exercise. Instead of determining their own genotype, introductory level students isolated plasmid DNA containing a section of the human TAS2R38 gene from Escherichia coli. Following PCR-mediated amplification of a section of the TAS2R38 gene spanning the SNP at position 785, students determined their assigned genotype by restriction enzyme digestion and agarose gel electrophoresis. Using the course wide genotype and phenotype data, students found that there was an association between TAS2R38 genotype and the age of persistent P. aeruginosa acquisition in cystic fibrosis "patients." Assessment data demonstrated that students taking part in this new TAS2R38 laboratory activity made clear learning gains.

  9. Design and performance of a punch mechanism based pellet injector for alternative injection in the large helical device.

    Science.gov (United States)

    Mishra, J S; Sakamoto, R; Motojima, G; Matsuyama, A; Yamada, H

    2011-02-01

    A low speed single barrel pellet injector, using a mechanical punch device has been developed for alternative injection in the large helical device. A pellet is injected by the combined operation of a mechanical punch and a pneumatic propellant system. The pellet shape is cylindrical, 3 mm in diameter and 3 mm in length. Using this technique the speed of the pellet can be controlled flexibly in the range of 100-450 m/s, and a higher speed can be feasible for a higher gas pressure. The injector is equipped with a guide tube selector to direct the pellet to different injection locations. Pellets are exposed to several curved parts with the curvature radii R(c) = 0.8 and 0.3 m when they are transferred in guided tubes to the respective injection locations. Pellet speed variation with pressure at different pellet formation temperatures has been observed. Pellet intactness tests through these guide tubes show a variation in the intact speed limit over a range of pellet formation temperatures from 6.5 to 9.8 K. Pellet speed reduction of less than 6% has been observed after the pellet moves through the curved guide tubes.

  10. Thermal design of lithium bromide-water solution vapor absorption cooling system for indirect evaporative cooling for IT pod

    Science.gov (United States)

    Sawant, Digvijay Ramkrishna

    Nowadays with increase use of internet, mobile there is increase in heat which ultimately increases the efficient cooling system of server room or IT POD. Use of traditional ways of cooling system has ultimately increased CO2 emission and depletion of CFC's are serious environmental issues which led scientific people to improve cooling techniques and eliminate use of CFC's. To reduce dependency on fossil fuels and 4environmental friendly system needed to be design. For being utilizing low grade energy source such as solar collector and reducing dependency on fossil fuel vapour absorption cooling system has shown a great driving force in today's refrigeration systems. This LiBr-water aabsorption cooling consists of five heat exchanger namely: Evaporator, Absorber, Solution Heat Exchanger, Generator, Condenser. The thermal design was done for a load of 23 kW and the procedure was described in the thesis. There are 120 servers in the IT POD emitting 196 W of heat each on full load and some of the heat was generated by the computer placed inside the IT POD. A detailed procedure has been discussed. A excel spreadsheet was to prepared with varying tube sizes to see the effect on flows and ultimately overall heat transfer coefficient.

  11. CFORM- LINEAR CONTROL SYSTEM DESIGN AND ANALYSIS: CLOSED FORM SOLUTION AND TRANSIENT RESPONSE OF THE LINEAR DIFFERENTIAL EQUATION

    Science.gov (United States)

    Jamison, J. W.

    1994-01-01

    CFORM was developed by the Kennedy Space Center Robotics Lab to assist in linear control system design and analysis using closed form and transient response mechanisms. The program computes the closed form solution and transient response of a linear (constant coefficient) differential equation. CFORM allows a choice of three input functions: the Unit Step (a unit change in displacement); the Ramp function (step velocity); and the Parabolic function (step acceleration). It is only accurate in cases where the differential equation has distinct roots, and does not handle the case for roots at the origin (s=0). Initial conditions must be zero. Differential equations may be input to CFORM in two forms - polynomial and product of factors. In some linear control analyses, it may be more appropriate to use a related program, Linear Control System Design and Analysis (KSC-11376), which uses root locus and frequency response methods. CFORM was written in VAX FORTRAN for a VAX 11/780 under VAX VMS 4.7. It has a central memory requirement of 30K. CFORM was developed in 1987.

  12. Study of the underlying electrochemistry of polycrystalline gold electrodes in aqueous solution and electrocatalysis by large amplitude fourier transformed alternating current voltammetry.

    Science.gov (United States)

    Lertanantawong, Benchaporn; O'Mullane, Anthony P; Surareungchai, Werasak; Somasundrum, Mithran; Declan Burke, L; Bond, Alan M

    2008-03-18

    Polycrystalline gold electrodes of the kind that are routinely used in analysis and catalysis in aqueous media are often regarded as exhibiting relatively simple double-layer charging/discharging and monolayer oxide formation/removal in the positive potential region. Application of the large amplitude Fourier transformed alternating current (FT-ac) voltammetric technique that allows the faradaic current contribution of fast electron-transfer processes to be emphasized in the higher harmonic components has revealed the presence of well-defined faradaic (premonolayer oxidation) processes at positive potentials in the double-layer region in acidic and basic media which are enhanced by electrochemical activation. These underlying quasi-reversible interfacial electron-transfer processes may mediate the course of electrocatalytic oxidation reactions of hydrazine, ethylene glycol, and glucose on gold electrodes in aqueous media. The observed responses support key assumptions associated with the incipient hydrous oxide adatom mediator (IHOAM) model of electrocatalysis.

  13. Applying visual attention theory to transportation safety research and design: evaluation of alternative automobile rear lighting systems.

    Science.gov (United States)

    McIntyre, Scott E; Gugerty, Leo

    2014-06-01

    This field experiment takes a novel approach in applying methodologies and theories of visual search to the subject of conspicuity in automobile rear lighting. Traditional rear lighting research has not used the visual search paradigm in experimental design. It is our claim that the visual search design uniquely uncovers visual attention processes operating when drivers search the visual field that current designs fail to capture. This experiment is a validation and extension of previous simulator research on this same topic and demonstrates that detection of red automobile brake lamps will be improved if tail lamps are another color (in this test, amber) rather than the currently mandated red. Results indicate that when drivers miss brake lamp onset in low ambient light, RT and error are reduced in detecting the presence and absence of red brake lamps with multiple lead vehicles when tail lamps are not red compared to current rear lighting which mandates red tail lamps. This performance improvement is attributed to efficient visual processing that automatically segregates tail (amber) and brake (red) lamp colors into distractors and targets respectively.

  14. An alternative strategy for targeted gene replacement in plants using a dual-sgRNA/Cas9 design.

    Science.gov (United States)

    Zhao, Yongping; Zhang, Congsheng; Liu, Wenwen; Gao, Wei; Liu, Changlin; Song, Gaoyuan; Li, Wen-Xue; Mao, Long; Chen, Beijiu; Xu, Yunbi; Li, Xinhai; Xie, Chuanxiao

    2016-04-01

    Precision DNA/gene replacement is a promising genome-editing tool that is highly desirable for molecular engineering and breeding by design. Although the CRISPR/Cas9 system works well as a tool for gene knockout in plants, gene replacement has rarely been reported. Towards this end, we first designed a combinatory dual-sgRNA/Cas9 vector (construct #1) that successfully deleted miRNA gene regions (MIR169a and MIR827a). The deletions were confirmed by PCR and subsequent sequencing, yielding deletion efficiencies of 20% and 24% on MIR169a and MIR827a loci, respectively. We designed a second structure (construct #2) that contains sites homologous to Arabidopsis TERMINAL FLOWER 1 (TFL1) for homology-directed repair (HDR) with regions corresponding to the two sgRNAs on the modified construct #1. The two constructs were co-transformed into Arabidopsis plants to provide both targeted deletion and donor repair for targeted gene replacement by HDR. Four of 500 stably transformed T0 transgenic plants (0.8%) contained replaced fragments. The presence of the expected recombination sites was further confirmed by sequencing. Therefore, we successfully established a gene deletion/replacement system in stably transformed plants that can potentially be utilized to introduce genes of interest for targeted crop improvement.

  15. Analysis of alternative push-pull-test-designs for determining in-situ trapping of CO2

    Science.gov (United States)

    Rasmusson, M.; Rasmusson, K.; Fagerlund, F.; Niemi, A.; Bensabat, J.; Shtivelman, V.

    2012-04-01

    Modeling results of different single-well push-pull (injection-withdrawal) test designs have been analyzed for their ability to determine residual and dissolution trapping of CO2 in-situ. The modeling aims to improve the design of a CO2 push-pull test that will be part of the field experiment conducted at the Heletz site, Israel, within the EU FP7 MUSTANG project. The injection will take place in a saline formation, where the target layer, an about 10 m thick sandstone layer composed of three layers, is located at a depth of 1600 m. Single-well experiments complement two-well injection-monitoring tests in that they offer a way of reducing heterogeneity effects on CO2 transport in comparison to two-well tests. The test scenarios simulated combine thermal, hydraulic and tracer tests in line with the work by Zhang et al (2011), where the test sequences have three main stages divided into (i) reference tests, (ii) creation of a zone of residual gas saturation and (iii) testing during residual gas saturation conditions. One of the main interests is to compare different ways of creating the residual zone, the two principal approaches being to push the mobile CO2 away by injecting CO2 saturated water, thus leaving the residual zone behind or by pumping the mobile CO2 back. Implications of the different designs on optimal use of tracers are also analyzed. Inverse modeling with the iTOUGH2/EOS17 and EOS7c simulators is used to analyze the ability of the competing test designs to accurately determine parameters of main interest during CO2 sequestration, in particular the residual gas saturation and dissolution. The inverse modeling approach uses results from e.g. sensitivity analysis and uncertainty propagation analysis to make design decisions leading to improvements in the test scenarios, choosing the optimum pumping and injection rates, heating effects, amount of CO2 used, tracer and method to create the zone of residual CO2 trapping, leading to a test design that will

  16. Design challenges and gaps in standards in developing an interoperable zero footprint DI thin client for use in image-enabled electronic health record solutions

    Science.gov (United States)

    Agrawal, Arun; Koff, David; Bak, Peter; Bender, Duane; Castelli, Jane

    2015-03-01

    The deployment of regional and national Electronic Health Record solutions has been a focus of many countries throughout the past decade. A major challenge for these deployments has been support for ubiquitous image viewing. More specifically, these deployments require an imaging solution that can work over the Internet, leverage any point of service device: desktop, tablet, phone; and access imaging data from any source seamlessly. Whereas standards exist to enable ubiquitous image viewing, few if any solutions exist that leverage these standards and meet the challenge. Rather, most of the currently available web based DI viewing solutions are either proprietary solutions or require special plugins. We developed a true zero foot print browser based DI viewing solution based on the Web Access DICOM Objects (WADO) and Cross-enterprise Document Sharing for Imaging (XDS-I.b) standards to a) demonstrate that a truly ubiquitous image viewer can be deployed; b) identify the gaps in the current standards and the design challenges for developing such a solution. The objective was to develop a viewer, which works on all modern browsers on both desktop and mobile devices. The implementation allows basic viewing functionalities of scroll, zoom, pan and window leveling (limited). The major gaps identified in the current DICOM WADO standards are a lack of ability to allow any kind of 3D reconstruction or MPR views. Other design challenges explored include considerations related to optimization of the solution for response time and low memory foot print.

  17. Evaluation of simulation alternatives for the brute-force ray-tracing approach used in backlight design

    Science.gov (United States)

    Desnijder, Karel; Hanselaer, Peter; Meuret, Youri

    2016-04-01

    A key requirement to obtain a uniform luminance for a side-lit LED backlight is the optimised spatial pattern of structures on the light guide that extract the light. The generation of such a scatter pattern is usually performed by applying an iterative approach. In each iteration, the luminance distribution of the backlight with a particular scatter pattern is analysed. This is typically performed with a brute-force ray-tracing algorithm, although this approach results in a time-consuming optimisation process. In this study, the Adding-Doubling method is explored as an alternative way for evaluating the luminance of a backlight. Due to the similarities between light propagating in a backlight with extraction structures and light scattering in a cloud of light scatterers, the Adding-Doubling method which is used to model the latter could also be used to model the light distribution in a backlight. The backlight problem is translated to a form upon which the Adding-Doubling method is directly applicable. The calculated luminance for a simple uniform extraction pattern with the Adding-Doubling method matches the luminance generated by a commercial raytracer very well. Although successful, no clear computational advantage over ray tracers is realised. However, the dynamics of light propagation in a light guide as used the Adding-Doubling method, also allow to enhance the efficiency of brute-force ray-tracing algorithms. The performance of this enhanced ray-tracing approach for the simulation of backlights is also evaluated against a typical brute-force ray-tracing approach.

  18. Alternative Medicine

    Science.gov (United States)

    ... Involved News About Us Donate In This Section Alternative Medicine en Español email Send this article to a ... Dr. Yvonne Ou on Lifestyle Modifications and Glaucoma Alternative medicine may be defined as non-standard, unconventional treatments ...

  19. MRS Action Plan Task B report: Analyses of alternative designs and operating approaches for a Monitored Retrievable Storage Facility

    Energy Technology Data Exchange (ETDEWEB)

    Woods, W.D.; Jowdy, A.K.; Keehn, C.H.; Gale, R.M.; Smith, R.I.

    1988-12-01

    The Nuclear Waste Policy Amendments Act (NWPAA) instituted a number of changes in the DOE commercial nuclear waste management system. After passage of the Act, the DOE initiated a number of systems studies to reevaluate the role of Monitored Retrievable Storage (MRS) within the federal waste management system. This report summarizes the results of a study to determine the schedules and costs of developing those MRS facilities needed under a number of scenarios, with differing functions allocated to the MRS and/or different spent fuel acceptance schedules. Nine cases were defined for the system study, seven of which included an MRS Facility. The study cases or scenarios evaluated varied relative to the specific functions to be performed at the MRS. The scenarios ranged in magnitude from storage and shipment of bare, intact spent fuel to consolidating the spent fuel into repository emplacement containers prior to storage and shipment. Each scenario required specific modifications to be made to the design developed for the MRS proposal to Congress (the Conceptual Design Report). 41 figs., 326 tabs.

  20. Response surface modeling of Pb(II) removal from aqueous solution by Pistacia vera L.: Box-Behnken experimental design.

    Science.gov (United States)

    Yetilmezsoy, Kaan; Demirel, Sevgi; Vanderbei, Robert J

    2009-11-15

    A three factor, three-level Box-Behnken experimental design combining with response surface modeling (RSM) and quadratic programming (QP) was employed for maximizing Pb(II) removal from aqueous solution by Antep pistachio (Pistacia vera L.) shells based on 17 different experimental data obtained in a lab-scale batch study. Three independent variables (initial pH of solution (pH(0)) ranging from 2.0 to 5.5, initial concentration of Pb(II) ions (C(0)) ranging from 5 to 50 ppm, and contact time (t(C)) ranging from 5 to 120 min) were consecutively coded as x(1), x(2) and x(3) at three levels (-1, 0 and 1), and a second-order polynomial regression equation was then derived to predict responses. The significance of independent variables and their interactions were tested by means of the analysis of variance (ANOVA) with 95% confidence limits (alpha=0.05). The standardized effects of the independent variables and their interactions on the dependent variable were also investigated by preparing a Pareto chart. The optimum values of the selected variables were obtained by solving the quadratic regression model, as well as by analysing the response surface contour plots. The optimum coded values of three test variables were computed as x(1)=0.125, x(2)=0.707, and x(3)=0.107 by using a LOQO/AMPL optimization algorithm. The experimental conditions at this global point were determined to be pH(0)=3.97, C(0)=43.4 ppm, and t(C)=68.7 min, and the corresponding Pb(II) removal efficiency was found to be about 100%.