WorldWideScience

Sample records for alternating molecular architecture

  1. New architectures for molecular materials

    International Nuclear Information System (INIS)

    synthesis of a novel ruthenium-based [2]-catenane by double ring-closing metathesis using Grubbs' catalyst. The photochemical behaviour of the novel catenane architecture was investigated both to confirm the proposed structure and to explore possible future applications of the catenane as a light-driven molecular machine. (author)

  2. Alternative lengthening of telomeres: remodeling the telomere architecture

    Directory of Open Access Journals (Sweden)

    Dimitri eConomos

    2013-02-01

    Full Text Available To escape from the normal limits on proliferative potential, cancer cells must employ a means to counteract the gradual telomere attrition that accompanies semi-conservative DNA replication. While the majority of human cancers do this by up-regulating telomerase enzyme activity, most of the remainder use a homologous recombination-mediated mechanism of telomere elongation known as alternative lengthening of telomeres (ALT. Many molecular details of the ALT pathway are unknown, and even less is known regarding the mechanisms by which this pathway is activated. Here, we review current findings about telomere structure in ALT cells, including DNA sequence, shelterin content, and heterochromatic state. We speculate that remodeling of the telomere architecture may contribute to the emergence and maintenance of the ALT phenotype.

  3. Evaluating Architecture Implementation Alternatives based on Adaptibility Concerns

    OpenAIRE

    Aksit, Mehmet; Tekinerdogan, Bedir

    1999-01-01

    Software is rarely designed for ultimate adaptability, performance or reusability but rather it is a compromise of multiple considerations. Even for a simple architecture specification, one may identify many alternative implementations. This paper makes an attempt to depict the space of implementation alternatives of architectures, and to define rules for selecting them. The applicability of this approach is illustrated by means of a simple design problem.

  4. Earth architecture: An alternative for sustainable construction

    Directory of Open Access Journals (Sweden)

    Gloria Zuleta Roa

    2012-01-01

    Full Text Available The interest on the sustainability of the architecture done with earth becomes the departure point of this article on the use of earth as an option for sustainable constructions. It begins with an historical review of the use of earth as a building material in the World and specifically in Colombia; its characteristics in relation to the sustainability of the constructive processes and finally its contextualization within the regulations that govern the building processes.

  5. Earth architecture: An alternative for sustainable construction

    OpenAIRE

    Gloria Zuleta Roa

    2012-01-01

    The interest on the sustainability of the architecture done with earth becomes the departure point of this article on the use of earth as an option for sustainable constructions. It begins with an historical review of the use of earth as a building material in the World and specifically in Colombia; its characteristics in relation to the sustainability of the constructive processes and finally its contextualization within the regulations that govern the building processes.

  6. The Architecture of Chemical Alternatives Assessment.

    Science.gov (United States)

    Geiser, Kenneth; Tickner, Joel; Edwards, Sally; Rossi, Mark

    2015-12-01

    Chemical alternatives assessment is a method rapidly developing for use by businesses, governments, and nongovernment organizations seeking to substitute chemicals of concern in production processes and products. Chemical alternatives assessment is defined as a process for identifying, comparing, and selecting safer alternatives to chemicals of concern (including those in materials, processes, or technologies) on the basis of their hazards, performance, and economic viability. The process is intended to provide guidance for assuring that chemicals of concern are replaced with safer alternatives that are not likely to be later regretted. Conceptually, the assessment methods are developed from a set of three foundational pillars and five common principles. Based on a number of emerging alternatives assessment initiatives, in this commentary, we outline a chemical alternatives assessment blueprint structured around three broad steps: Scope, Assessment, and Selection and Implementation. Specific tasks and tools are identified for each of these three steps. While it is recognized that on-going practice will further refine and develop the method and tools, it is important that the structure of the assessment process remain flexible, adaptive, and focused on the substitution of chemicals of concern with safer alternatives. PMID:26630442

  7. Possible Circuit Architectures for Molecular Nanoelectronics

    Science.gov (United States)

    Likharev, Konstantin

    2003-03-01

    Chemically-directed self-assembly of molecular devices is apparently the only feasible way to continue the fast progress of microelectronics after its Moore-Laws-based development runs into the wall of physical and economic limitations [1]. The architectures of VLSI circuits using such devices should be substantially fault-tolerant and accommodate other their features including low transconductance. The most significant feature of all promising suggested architectures is the hybridization of three technologies: advanced CMOS, simple nanowire arrays, and molecular devices self-assembling on these wires. Molecular memory arrays may have a simple structure, and their simple prototypes have already been implemented experimentally [2]. In contrast, the logic circuit development is just starting. I will describe a family of neuromorphic networks based on so-called CrossNet arrays [3] that look promising for advanced information processing, starting from fast image recognition and beyond. This architecture may combine very high density (above 10^12 functions per cm^2) and relatively high speed (100-ns-scale latency of cell-to-cell communications) at acceptable power consumption. In future, these features may allow to put an artificial analog of the human cerebral cortex, capable of processing information and (hopefully) self-evolution at 4 to 5 orders of magnitude faster than its biological prototype, on a 20x20 cm^2 silicon wafer. [1] K. Likharev, "Electronics Below 20-nm", see http://rsfq1.physics.sunysb.edu/ likharev/nano/ForMorkoc.pdf. [2] See, e.g, http://nanotechweb.org/articles/news/1/9/8/1. [3] O. Turel and K. Likharev, Int. J. of Circuit Theory and Applications 31, No.1 (2003); see http://rsfq1.physics.sunysb.edu/ likharev/nano/Preprint070102.pdf.

  8. Design of Carborane Molecular Architectures via Electronic Structure Computations

    Directory of Open Access Journals (Sweden)

    Josep M. Oliva

    2009-01-01

    Full Text Available Quantum-mechanical electronic structure computations were employed to explore initial steps towards a comprehensive design of polycarborane architectures through assembly of molecular units. Aspects considered were (i the striking modification of geometrical parameters through substitution, (ii endohedral carboranes and proposed ejection mechanisms for energy/ion/atom/energy storage/transport, (iii the excited state character in single and dimeric molecular units, and (iv higher architectural constructs. A goal of this work is to find optimal architectures where atom/ion/energy/spin transport within carborane superclusters is feasible in order to modernize and improve future photoenergy processes.

  9. Alternative lengthening of telomeres: remodeling the telomere architecture

    OpenAIRE

    Conomos, Dimitri; Hilda A Pickett; Reddel, Roger R

    2013-01-01

    To escape from the normal limits on proliferative potential, cancer cells must employ a means to counteract the gradual telomere attrition that accompanies semi-conservative DNA replication. While the majority of human cancers do this by up-regulating telomerase enzyme activity, most of the remainder use a homologous recombination-mediated mechanism of telomere elongation known as alternative lengthening of telomeres (ALT). Many molecular details of the ALT pathway are unknown, and even less ...

  10. Molecular Architecture of the Yeast Monopolin Complex

    Energy Technology Data Exchange (ETDEWEB)

    Corbett, Kevin D.; Harrison, Stephen C. (Harvard-Med); (UCSD)

    2012-07-30

    The Saccharomyces cerevisiae monopolin complex directs proper chromosome segregation in meiosis I by mediating co-orientation of sister kinetochores on the meiosis I spindle. The monopolin subunits Csm1 and Lrs4 form a V-shaped complex that may directly crosslink sister kinetochores. We report here biochemical characterization of the monopolin complex subunits Mam1 and Hrr25 and of the complete four-protein monopolin complex. By purifying monopolin subcomplexes with different subunit combinations, we have determined the stoichiometry and overall architecture of the full monopolin complex. We have determined the crystal structure of Csm1 bound to a Mam1 fragment, showing how Mam1 wraps around the Csm1 dimer and alters the stoichiometry of kinetochore-protein binding by Csm1. We further show that the kinase activity of Hrr25 is altered by Mam1 binding, and we identify Hrr25 phosphorylation sites on Mam1 that may affect monopolin complex stability and/or kinetochore binding in meiosis.

  11. Molecular Architecture of the Retroviral Capsid.

    Science.gov (United States)

    Perilla, Juan R; Gronenborn, Angela M

    2016-05-01

    Retroviral capsid cores are proteinaceous containers that self-assemble to encase the viral genome and a handful of proteins that promote infection. Their function is to protect and aid in the delivery of viral genes to the nucleus of the host, and, in many cases, infection pathways are influenced by capsid-cellular interactions. From a mathematical perspective, capsid cores are polyhedral cages and, as such, follow well-defined geometric rules. However, marked morphological differences in shapes exist, depending on virus type. Given the specific roles of capsid in the viral life cycle, the availability of detailed molecular structures, particularly at assembly interfaces, opens novel avenues for targeted drug development against these pathogens. Here, we summarize recent advances in the structure and understanding of retroviral capsid, with particular emphasis on assemblies and the capsid cores. PMID:27039020

  12. From Molecular Gastronomy to Molecular Architecture: Reflections towards a new architectural praxis

    OpenAIRE

    Rocha, Joao

    2011-01-01

    The relationship between architecture and research has been barely discussed and by making use of critical reading this paper proposes to investigate how other disciplines started to use Research and Development (R&D) as part of their creative processes. In particular it explores how gastronomy has unfolded new R&D paths through the revolutionary work of three leading chefs: Ferrian Adria, Rene Redzepi and Grant Achatz, illustrating the deep impact that the use of R&D had in this field and ho...

  13. Alternate architectures and technologies for Intelsat type DSI design

    Science.gov (United States)

    Keelty, J. M.; Hatzigeorgiou, S.

    1983-01-01

    The architectural choices in the unit design have to do with the amount of storage and the type of storage in the unit, the type of high-speed interface, the type of echo-protection features, the FEC encoding, and the degree of human interface for testing and maintenance. Since the interpolation process takes time, the unit is by necessity memory-oriented, and an efficient choice of memory architecture is cardinal. The two principal design choices are referred to as 'oorder and storage' and 'storage and order.' Store-and-order implies storage of data on all received channels (regardless of whether they are to be processed), followed by data routing for selected channels. Order-and-store implies immediate selection of the traffic to be processed. The architecture is also affected by the choice of interface between the DSI (digital speech interpolation) and the 'satellite' side equipment. Although the principal choice is between word- and bit-oriented data transmission, tradeoffs exist involving handshaking for control signals as well.

  14. Community Energy: A Social Architecture for an Alternative Energy Future

    Science.gov (United States)

    Hoffman, Steven M.; High-Pippert, Angela

    2005-01-01

    Community energy based on a mix of distributed technologies offers a serious alternative to the current energy system. The nature of community energy and the role that such initiatives might play in the general fabric of civic life is not, however, well understood. Community energy initiatives might involve only those citizens who prefer to be…

  15. Web Service Clients on Mobile Android Devices: A Study on Architectural Alternatives and Client Performance

    OpenAIRE

    Knutsen, Johannes

    2009-01-01

    This paper studies Android, a new open source software stack initiated by Google, and the possibilities of developing a mobile client for MPower, a service oriented architecture platform based upon SOAP messaging. The study focuses on the architectural alternatives, their impacts on the mobile client application, Android’s performance on SOAP messaging, and how Web services’ design can be optimized to give well performing Android clients. The results from this study shows how different arch...

  16. Molecular architecture of transcription factor hotspots in early adipogenesis.

    Science.gov (United States)

    Siersbæk, Rasmus; Baek, Songjoon; Rabiee, Atefeh; Nielsen, Ronni; Traynor, Sofie; Clark, Nicholas; Sandelin, Albin; Jensen, Ole N; Sung, Myong-Hee; Hager, Gordon L; Mandrup, Susanne

    2014-06-12

    Transcription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly defined. Here, we have used digital genomic footprinting to precisely define factor localization at a genome-wide level during the early phase of 3T3-L1 adipocyte differentiation, which allows us to obtain detailed molecular insight into how transcription factors target hotspots. We demonstrate the formation of ATF-C/EBP heterodimers at a composite motif on chromatin, and we suggest that this may be a general mechanism for integrating external signals on chromatin. Furthermore, we find evidence of extensive recruitment of transcription factors to hotspots through alternative mechanisms not involving their known motifs and demonstrate that these alternative binding events are functionally important for hotspot formation and activity. Taken together, these findings provide a framework for understanding transcription factor cooperativity in hotspots. PMID:24857666

  17. Molecular Architecture of Transcription Factor Hotspots in Early Adipogenesis

    Directory of Open Access Journals (Sweden)

    Rasmus Siersbæk

    2014-06-01

    Full Text Available Transcription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly defined. Here, we have used digital genomic footprinting to precisely define factor localization at a genome-wide level during the early phase of 3T3-L1 adipocyte differentiation, which allows us to obtain detailed molecular insight into how transcription factors target hotspots. We demonstrate the formation of ATF-C/EBP heterodimers at a composite motif on chromatin, and we suggest that this may be a general mechanism for integrating external signals on chromatin. Furthermore, we find evidence of extensive recruitment of transcription factors to hotspots through alternative mechanisms not involving their known motifs and demonstrate that these alternative binding events are functionally important for hotspot formation and activity. Taken together, these findings provide a framework for understanding transcription factor cooperativity in hotspots.

  18. Hemophilia: Molecular diagnosis and alternatives of treatment.

    Directory of Open Access Journals (Sweden)

    Sandra Milena Bermeo

    2009-11-01

    Full Text Available La hemofilia es una enfermedad recesiva ligada al cromosoma X que generalmente padecen los hombres. El diagnóstico genético preimplantación (DGP, el diagnóstico prenatal y el diagnóstico molecular de las mutaciones que causan hemofilia, se realizan en investigaciones aisladas con el fin de hacer prevención primaria, asesorar a las portadoras y a sus familias, lo que ha permitido traer al mundo niños libres de esta enfermedad y también mejorar la calidad de vida de los afectados. Los esperanzadores procedimientos en terapia génica (TG han mostrado gran efectividad, se pretende con ella la producción normal de la proteína que está ausente o alterada en los afectados, pero en el momento los ensayos que se llevan a cabo en seres humanos están detenidos. Aquí se muestran otras terapias alternas que aunque están en fase de investigación, permitirían obtener una producción de proteína a largo término y que se han desarrollado gracias al entendimiento de la naturaleza molecular de los factores de la coagulación.

  19. Rapid architecture alternative modeling (RAAM): A framework for capability-based analysis of system of systems architectures

    Science.gov (United States)

    Iacobucci, Joseph V.

    The research objective for this manuscript is to develop a Rapid Architecture Alternative Modeling (RAAM) methodology to enable traceable Pre-Milestone A decision making during the conceptual phase of design of a system of systems. Rather than following current trends that place an emphasis on adding more analysis which tends to increase the complexity of the decision making problem, RAAM improves on current methods by reducing both runtime and model creation complexity. RAAM draws upon principles from computer science, system architecting, and domain specific languages to enable the automatic generation and evaluation of architecture alternatives. For example, both mission dependent and mission independent metrics are considered. Mission dependent metrics are determined by the performance of systems accomplishing a task, such as Probability of Success. In contrast, mission independent metrics, such as acquisition cost, are solely determined and influenced by the other systems in the portfolio. RAAM also leverages advances in parallel computing to significantly reduce runtime by defining executable models that are readily amendable to parallelization. This allows the use of cloud computing infrastructures such as Amazon's Elastic Compute Cloud and the PASTEC cluster operated by the Georgia Institute of Technology Research Institute (GTRI). Also, the amount of data that can be generated when fully exploring the design space can quickly exceed the typical capacity of computational resources at the analyst's disposal. To counter this, specific algorithms and techniques are employed. Streaming algorithms and recursive architecture alternative evaluation algorithms are used that reduce computer memory requirements. Lastly, a domain specific language is created to provide a reduction in the computational time of executing the system of systems models. A domain specific language is a small, usually declarative language that offers expressive power focused on a particular

  20. Molecular Architecture of Spinal Cord Injury Protein Interaction Network.

    Directory of Open Access Journals (Sweden)

    Ali Alawieh

    Full Text Available Spinal cord injury (SCI is associated with complex pathophysiological processes that follow the primary traumatic event and determine the extent of secondary damage and functional recovery. Numerous reports have used global and hypothesis-driven approaches to identify protein changes that contribute to the overall pathology of SCI in an effort to identify potential therapeutic interventions. In this study, we use a semi-automatic annotation approach to detect terms referring to genes or proteins dysregulated in the SCI literature and develop a curated SCI interactome. Network analysis of the SCI interactome revealed the presence of a rich-club organization corresponding to a "powerhouse" of highly interacting hub-proteins. Studying the modular organization of the network have shown that rich-club proteins cluster into modules that are specifically enriched for biological processes that fall under the categories of cell death, inflammation, injury recognition and systems development. Pathway analysis of the interactome and the rich-club revealed high similarity indicating the role of the rich-club proteins as hubs of the most prominent pathways in disease pathophysiology and illustrating the centrality of pro-and anti-survival signal competition in the pathology of SCI. In addition, evaluation of centrality measures of single nodes within the rich-club have revealed that neuronal growth factor (NGF, caspase 3, and H-Ras are the most central nodes and potentially an interesting targets for therapy. Our integrative approach uncovers the molecular architecture of SCI interactome, and provide an essential resource for evaluating significant therapeutic candidates.

  1. Molecular trajectories leading to the alternative fates of duplicate genes.

    Directory of Open Access Journals (Sweden)

    Michael Marotta

    Full Text Available Gene duplication generates extra gene copies in which mutations can accumulate without risking the function of pre-existing genes. Such mutations modify duplicates and contribute to evolutionary novelties. However, the vast majority of duplicates appear to be short-lived and experience duplicate silencing within a few million years. Little is known about the molecular mechanisms leading to these alternative fates. Here we delineate differing molecular trajectories of a relatively recent duplication event between humans and chimpanzees by investigating molecular properties of a single duplicate: DNA sequences, gene expression and promoter activities. The inverted duplication of the Glutathione S-transferase Theta 2 (GSTT2 gene had occurred at least 7 million years ago in the common ancestor of African great apes and is preserved in chimpanzees (Pan troglodytes, whereas a deletion polymorphism is prevalent in humans. The alternative fates are associated with expression divergence between these species, and reduced expression in humans is regulated by silencing mutations that have been propagated between duplicates by gene conversion. In contrast, selective constraint preserved duplicate divergence in chimpanzees. The difference in evolutionary processes left a unique DNA footprint in which dying duplicates are significantly more similar to each other (99.4% than preserved ones. Such molecular trajectories could provide insights for the mechanisms underlying duplicate life and death in extant genomes.

  2. Nanoscale molecular systems : designed phenyl-acetylene architectures

    OpenAIRE

    Eaton, Thomas R.

    2015-01-01

    Molecular design should be about fulfilling function. However designing molecular structures that will fulfill a particular function is incredibly difficult. The delicate interplay of structure-property relationships and further emergent phenomena that arise when molecules come together are very unpredictable. This thesis sets out tools to guide the budding molecular architect in successfully making the transition in mindset from structure-property relationships to structure-function relatio...

  3. Description Model of Warehouse Architecture for Clinical Test at the Molecular Immunology Centre

    Directory of Open Access Journals (Sweden)

    Anthony Rafael Sotolongo León

    2012-05-01

    Full Text Available Accurate and detailed description of the architecture of computer systems is very important to achieve success in their development. As informatic solutions, data warehouses and software support decision-making in institutions that need to implement a detailed description of the architecture. Ralph Kimball proposes the aspects to be considered of the description and explains how it is done. There are specific models used to describe the architecture such as Kruchten 4 +1 views of meta-model or the Common Warehouse Metamodel (CWM however these models do not meet the need of the description that requires a data warehouse that integrates information from clinical trials of the Molecular Immunology Centre (CIM. In this paper we propose a model for describing the data warehouse architecture that fits the needs of the Molecular Immunology Center following the Kimball framework and using as UML 2.0 modeling language.

  4. Effect of confinement and molecular architecture on interfacial dynamics

    Science.gov (United States)

    Chrissopoulou, K.; Androulaki, K.; Prevosto, D.; Labardi, M.; Anastasiadis, S. H.

    2016-05-01

    The dynamics of polyester polyols in the bulk, under confinement when the polymers are intercalated within the galleries of a hydrophilic clay and close to the inorganic surfaces is investigated utilizing Dielectric Relaxation Spectroscopy (DRS). A series of linear biobased polyesters with hydroxyl end groups were utilized in the bulk and in nanohybrids and the results were compared with the case of hyperbranched polymers of similar chemistry but non-linear architecture. A broad range of temperatures below and above the bulk polymer glass transition temperature, Tg, was investigated covering both the regimes of beta-like local processes and segmental (alpha-process) dynamics. The polymer dynamics observed in all the nanocomposites are quite different compared to the bulk due to the different interactions whereas differences are seen due to the architecture as well. Moreover, non-standard local dielectric spectroscopy has been used to investigate the nanocomposites dynamics at the local scale: polymer relaxation has been investigated in the same material both close and far from the MMT surfaces. The comparison of the results from the two techniques allowed the understanding, in more detail, of the influence of the complex interfacial interactions on the relaxation dynamics.

  5. Molecular architecture of transcription factor hotspots in early adipogenesis

    DEFF Research Database (Denmark)

    Siersbæk, Rasmus; Baek, Songjoon; Rabiee, Atefeh; Nielsen, Ronni; Traynor, Sofie; Clarke, Nicholas; Sandelin, Albin Gustav; Jensen, Ole N.; Sung, Myong-Hee; Hager, Gordon L.; Mandrup, Susanne

    2014-01-01

    Transcription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly defined. Here, we have used digital genomic footprint......Transcription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly defined. Here, we have used digital genomic...

  6. Porphyrin architectures tailored for studies of molecular information storage.

    Science.gov (United States)

    Carcel, Carole M; Laha, Joydev K; Loewe, Robert S; Thamyongkit, Patchanita; Schweikart, Karl-Heinz; Misra, Veena; Bocian, David F; Lindsey, Jonathan S

    2004-10-01

    A molecular approach to information storage employs redox-active molecules tethered to an electroactive surface. Zinc porphyrins tethered to Au(111) or Si(100) provide a benchmark for studies of information storage. Three sets of porphyrins have been synthesized for studies of the interplay of molecular design and charge-storage properties: (1) A set of porphyrins is described for probing the effect of surface attachment atom on electron-transfer kinetics. Each porphyrin bears a meso-CH2X group for surface attachment where X = OH, SAc, or SeAc. (2) A set of porphyrins is described for studying the effect of surface-charge density in monolayers. Each porphyrin bears a benzyl alcohol for surface attachment and three nonlinking meso substituents of a controlled degree of bulkiness. (3) A set of porphyrins is described that enables investigation of on-chip patterning of the electrolyte. Each porphyrin bears a formyl group distal to the surface attachment group for subsequent derivatization with a molecular entity that comprises the electrolyte. Taken together, this collection of molecules enables a variety of studies to elucidate design issues in molecular-based information storage. PMID:15387598

  7. Molecular Architecture of the Bacterial Flagellar Motor in Cells

    OpenAIRE

    Zhao, Xiaowei; Norris, Steven J; Liu, Jun

    2014-01-01

    The flagellum is one of the most sophisticated self-assembling molecular machines in bacteria. Powered by the proton-motive force, the flagellum rapidly rotates in either a clockwise or counterclockwise direction, which ultimately controls bacterial motility and behavior. Escherichia coli and Salmonella enterica have served as important model systems for extensive genetic, biochemical, and structural analysis of the flagellum, providing unparalleled insights into its structure, function, and ...

  8. Molecular analysis of plant architecture in Arabidopsis thaliana using activation tagging.

    OpenAIRE

    Chalfun Junior, A.

    2004-01-01

    Keywords: Arabidopsisthaliana, activation tagging, T-DNA, transposon, mutants, enhancer, DNA methylation, plant architecture, development, forward/reverse genetics, lateral organs, flower, vascular tissue, HLH, transmembrane, transcription factorsPlant development is one of the most important aspects of plant's life cycle that has extensively been studied at the morphological, genetic and molecular level. It is import for systematic and taxonomic classification, but also for applied agronomic...

  9. Counter-ion distribution around flexible polyelectrolytes having different molecular architecture.

    Science.gov (United States)

    Chremos, Alexandros; Douglas, Jack F

    2016-03-01

    We explore the monovalent counter-ion distribution around flexible highly-charged polyelectrolytes with different molecular architectures (linear chains, stars, and unknotted and trefoil rings) using molecular dynamics simulations that include an explicit solvent that interacts with the polyelectrolyte. In particular, we find that the molecular topology influences the fraction of counter-ions transiently associating with the polyelectrolyte on a scale of the order of the chain segments, forming a "condensed" counter-ion interfacial layer. As with the hydrogen bonding of water to proteins and other polymers, the persistence time of these interfacial "bound" counter-ions is relatively short, O(1 ps), and we characterize the fluctuations in the number of the counter-ions populating the interfacial layer. We also find that the counter-ions are distributed in a non-uniform fashion on the polyelectrolyte backbone, forming dynamical clusters whose form and average size is sensitive to molecular architecture. In addition, we find that the residual bound counter-ions, not located in either the interfacial layer or the bulk solution, form a diffuse ionic cloud around the polyelectrolyte due to the uncompensated polyelectrolyte charge along the backbone. Generally charge valence strongly influences the extent of the diffuse counter-ion cloud, but in the case of monovalent counter-ions, we find that the size of the diffuse counter-ion cloud nearly coincides with the polyelectrolyte radius of gyration, independent of molecular topology. PMID:26864861

  10. Modeling and optimization of multiple unmanned aerial vehicles system architecture alternatives.

    Science.gov (United States)

    Qin, Dongliang; Li, Zhifei; Yang, Feng; Wang, Weiping; He, Lei

    2014-01-01

    Unmanned aerial vehicle (UAV) systems have already been used in civilian activities, although very limitedly. Confronted different types of tasks, multi UAVs usually need to be coordinated. This can be extracted as a multi UAVs system architecture problem. Based on the general system architecture problem, a specific description of the multi UAVs system architecture problem is presented. Then the corresponding optimization problem and an efficient genetic algorithm with a refined crossover operator (GA-RX) is proposed to accomplish the architecting process iteratively in the rest of this paper. The availability and effectiveness of overall method is validated using 2 simulations based on 2 different scenarios. PMID:25140328

  11. MolDiA: a novel molecular diversity analysis tool. 1. Principles and architecture.

    Science.gov (United States)

    Maldonado, Ana G; Doucet, Jean-Pierre; Petitjean, Michel; Fan, Bo-Tao

    2007-01-01

    We introduce the principles and the architecture of a user-friendly software named MOLDIA (Molecular Diversity Analysis) which aims to the comparison of diverse molecular data sets through an XML structured database of predefined fragments. The MOLDIA descriptors are composed of complex fingerprint-like structures, which enclose not only structural information but also physicochemical property data. The system architecture includes the use of customizable weights on molecular descriptors and different choices of similarity/diversity measures to analyze the given data sets. Intermolecular comparisons using Ullmann's algorithm were optimized by the use of fuzzy logic, generic atoms, and a whole system of chemical graph analysis. We have found that customizing the similarity/diversity computation using structural and/or properties weights and choosing the level of fuzziness of the molecular comparison allow the user to adapt the tool to particular needs and increases the possibilities of MolDiA applications. The implementation of XML Web technologies has proven to improve and ease the extraction, processing, and analysis of chemical information. PMID:17979264

  12. Criteria for Evaluating Alternative Network and Link Layer Protocols for the NASA Constellation Program Communication Architecture

    Science.gov (United States)

    Benbenek, Daniel; Soloff, Jason; Lieb, Erica

    2010-01-01

    Selecting a communications and network architecture for future manned space flight requires an evaluation of the varying goals and objectives of the program, development of communications and network architecture evaluation criteria, and assessment of critical architecture trades. This paper uses Cx Program proposed exploration activities as a guideline; lunar sortie, outpost, Mars, and flexible path options are described. A set of proposed communications network architecture criteria are proposed and described. They include: interoperability, security, reliability, and ease of automating topology changes. Finally a key set of architecture options are traded including (1) multiplexing data at a common network layer vs. at the data link layer, (2) implementing multiple network layers vs. a single network layer, and (3) the use of a particular network layer protocol, primarily IPv6 vs. Delay Tolerant Networking (DTN). In summary, the protocol options are evaluated against the proposed exploration activities and their relative performance with respect to the criteria are assessed. An architectural approach which includes (a) the capability of multiplexing at both the network layer and the data link layer and (b) a single network layer for operations at each program phase, as these solutions are best suited to respond to the widest array of program needs and meet each of the evaluation criteria.

  13. Nuclear Architecture and Patterns of Molecular Evolution Are Correlated in the Ciliate Chilodonella uncinata.

    Science.gov (United States)

    Maurer-Alcalá, Xyrus X; Katz, Laura A

    2016-01-01

    The relationship between nuclear architecture and patterns of molecular evolution in lineages across the eukaryotic tree of life is not well understood, partly because molecular evolution is traditionally explored as changes in base pairs along a linear sequence without considering the context of nuclear position of chromosomes. The ciliate Chilodonella uncinata is an ideal system to address the relationship between nuclear architecture and patterns of molecular evolution as the somatic macronucleus of this ciliate is composed of a peripheral DNA-rich area (orthomere) and a DNA-poor central region (paramere) to form a "heteromeric" macronucleus. Moreover, because the somatic chromosomes of C. uncinata are highly processed into "gene-sized" chromosomes (i.e., nanochromosomes), we can assess fine-scale relationships between location and sequence evolution. By combining fluorescence microscopy and analyses of transcriptome data from C. uncinata, we find that highly expressed genes have the greatest codon usage bias and are enriched in DNA-poor regions. In contrast, genes with less biased sequences tend to be concentrated in DNA abundant areas, at least during vegetative growth. Our analyses are consistent with recent work in plants and animals where nuclear architecture plays a role in gene expression. At the same time, the unusual localization of nanochromosomes suggests that the highly structured nucleus in C. uncinata may create a "gene bank" that facilitates rapid changes in expression of genes required only in specific life history stages. By using "nonmodel" organisms like C. uncinata, we can explore the universality of eukaryotic features while also providing examples of novel properties (i.e., the presence of a gene bank) that build from these features. PMID:27189988

  14. Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates

    Directory of Open Access Journals (Sweden)

    Mohamed Elamir F. Hegazy

    2015-05-01

    Full Text Available Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.

  15. Multi-scale Visualization of Molecular Architecture Using Real-Time Ambient Occlusion in Sculptor.

    Science.gov (United States)

    Wahle, Manuel; Wriggers, Willy

    2015-10-01

    The modeling of large biomolecular assemblies relies on an efficient rendering of their hierarchical architecture across a wide range of spatial level of detail. We describe a paradigm shift currently under way in computer graphics towards the use of more realistic global illumination models, and we apply the so-called ambient occlusion approach to our open-source multi-scale modeling program, Sculptor. While there are many other higher quality global illumination approaches going all the way up to full GPU-accelerated ray tracing, they do not provide size-specificity of the features they shade. Ambient occlusion is an aspect of global lighting that offers great visual benefits and powerful user customization. By estimating how other molecular shape features affect the reception of light at some surface point, it effectively simulates indirect shadowing. This effect occurs between molecular surfaces that are close to each other, or in pockets such as protein or ligand binding sites. By adding ambient occlusion, large macromolecular systems look much more natural, and the perception of characteristic surface features is strongly enhanced. In this work, we present a real-time implementation of screen space ambient occlusion that delivers realistic cues about tunable spatial scale characteristics of macromolecular architecture. Heretofore, the visualization of large biomolecular systems, comprising e.g. hundreds of thousands of atoms or Mega-Dalton size electron microscopy maps, did not take into account the length scales of interest or the spatial resolution of the data. Our approach has been uniquely customized with shading that is tuned for pockets and cavities of a user-defined size, making it useful for visualizing molecular features at multiple scales of interest. This is a feature that none of the conventional ambient occlusion approaches provide. Actual Sculptor screen shots illustrate how our implementation supports the size-dependent rendering of molecular

  16. Composite-cluster states and alternative architectures for one-way quantum computation

    OpenAIRE

    Milne, Darran F.; Korolkova, Natalia V.

    2012-01-01

    We propose a new architecture for the measurement-based quantum computation model. The new design relies on small composite light-atom primary clusters. These are then assembled into cluster arrays using ancillary light modes and the actual computation is run on such a cellular cluster. We show how to create the primary clusters, which are Gaussian cluster states composed of both light and atomic modes. These are entangled via QND interactions and beamsplitters and the scheme is well describe...

  17. Architectural Prototyping

    DEFF Research Database (Denmark)

    Bardram, Jakob; Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2004-01-01

    A major part of software architecture design is learning how specific architectural designs balance the concerns of stakeholders. We explore the notion of "architectural prototypes", correspondingly architectural prototyping, as a means of using executable prototypes to investigate stakeholders......' concerns with respect to a system under development. An architectural prototype is primarily a learning and communication vehicle used to explore and experiment with alternative architectural styles, features, and patterns in order to balance different architectural qualities. The use of architectural...... prototypes in the development process is discussed, and we argue that such prototypes can play a role throughout the entire process. The use of architectural prototypes is illustrated by three distinct cases of creating software systems. We argue that architectural prototyping can provide key insights that...

  18. Architectural prototyping

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2004-01-01

    A major part of software architecture design is learning how specific architectural designs balance the concerns of stakeholders. We explore the notion of "architectural prototypes", correspondingly architectural prototyping, as a means of using executable prototypes to investigate stakeholders......' concerns with respect to a system under development. An architectural prototype is primarily a learning and communication vehicle used to explore and experiment with alternative architectural styles, features, and patterns in order to balance different architectural qualities. The use of architectural...... prototypes in the development process is discussed, and we argue that such prototypes can play a role throughout the entire process. The use of architectural prototypes is illustrated by three distinct cases of creating software systems. We argue that architectural prototyping can provide key insights that...

  19. Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex.

    Science.gov (United States)

    Aydin, Halil; Sultana, Azmiri; Li, Sheng; Thavalingam, Annoj; Lee, Jeffrey E

    2016-06-23

    Fertilization is an essential biological process in sexual reproduction and comprises a series of molecular interactions between the sperm and egg. The fusion of the haploid spermatozoon and oocyte is the culminating event in mammalian fertilization, enabling the creation of a new, genetically distinct diploid organism. The merger of two gametes is achieved through a two-step mechanism in which the sperm protein IZUMO1 on the equatorial segment of the acrosome-reacted sperm recognizes its receptor, JUNO, on the egg surface. This recognition is followed by the fusion of the two plasma membranes. IZUMO1 and JUNO proteins are indispensable for fertilization, as constitutive knockdown of either protein results in mice that are healthy but infertile. Despite their central importance in reproductive medicine, the molecular architectures of these proteins and the details of their functional roles in fertilization are not known. Here we present the crystal structures of human IZUMO1 and JUNO in unbound and bound conformations. The human IZUMO1 structure exhibits a distinct boomerang shape and provides structural insights into the IZUMO family of proteins. Human IZUMO1 forms a high-affinity complex with JUNO and undergoes a major conformational change within its N-terminal domain upon binding to the egg-surface receptor. Our results provide insights into the molecular basis of sperm-egg recognition, cross-species fertilization, and the barrier to polyspermy, thereby promising benefits for the rational development of non-hormonal contraceptives and fertility treatments for humans and other mammals. PMID:27309818

  20. Polyglutamine Expansion Alters the Dynamics and Molecular Architecture of Aggregates in Dentatorubropallidoluysian Atrophy*

    Science.gov (United States)

    Hinz, Justyna; Lehnhardt, Lothar; Zakrzewski, Silke; Zhang, Gong; Ignatova, Zoya

    2012-01-01

    Preferential accumulation of mutant proteins in the nucleus has been suggested to be the molecular culprit that confers cellular toxicity in the neurodegenerative disorders caused by polyglutamine (polyQ) expansion. Here, we use dynamic imaging approaches, orthogonal cross-seeding, and composition analysis to examine the dynamics and structure of nuclear and cytoplasmic inclusions of atrophin-1, implicated in dentatorubropallidoluysian atrophy, a polyQ-based disease with complex clinical features. Our results reveal a large heterogeneity in the dynamics of the nuclear inclusions compared with the compact and immobile cytoplasmic aggregates. At least two types of inclusions of expanded atrophin-1 with different mobility of the molecular species and ability to exchange with the surrounding monomer pool coexist in the nucleus. Intriguingly, the enrichment of nuclear inclusions with slow dynamics parallels changes in the aggregate core architecture that are dominated by the polyQ stretch. We propose that the observed complexity in the dynamics of the nuclear inclusions provides a molecular explanation for the enhanced cellular toxicity of the nuclear aggregates in polyQ-based neurodegeneration. PMID:22134925

  1. An efficient implementation of parallel molecular dynamics method on SMP cluster architecture

    International Nuclear Information System (INIS)

    The authors have applied MPI/OpenMP hybrid parallel programming model to parallelize a molecular dynamics (MD) method on a symmetric multiprocessor (SMP) cluster architecture. In that architecture, it can be expected that the hybrid parallel programming model, which uses the message passing library such as MPI for inter-SMP node communication and the loop directive such as OpenMP for intra-SNP node parallelization, is the most effective one. In this study, the parallel performance of the hybrid style has been compared with that of conventional flat parallel programming style, which uses only MPI, both in cases the fast multipole method (FMM) is employed for computing long-distance interactions and that is not employed. The computer environments used here are Hitachi SR8000/MPP placed at the University of Tokyo. The results of calculation are as follows. Without FMM, the parallel efficiency using 16 SMP nodes (128 PEs) is: 90% with the hybrid style, 75% with the flat-MPI style for MD simulation with 33,402 atoms. With FMM, the parallel efficiency using 16 SMP nodes (128 PEs) is: 60% with the hybrid style, 48% with the flat-MPI style for MD simulation with 117,649 atoms. (author)

  2. Super-Resolution Molecular and Functional Imaging of Nanoscale Architectures in Life and Materials Science

    KAUST Repository

    Habuchi, Satoshi

    2014-06-12

    Super-resolution (SR) fluorescence microscopy has been revolutionizing the way in which we investigate the structures, dynamics, and functions of a wide range of nanoscale systems. In this review, I describe the current state of various SR fluorescence microscopy techniques along with the latest developments of fluorophores and labeling for the SR microscopy. I discuss the applications of SR microscopy in the fields of life science and materials science with a special emphasis on quantitative molecular imaging and nanoscale functional imaging. These studies open new opportunities for unraveling the physical, chemical, and optical properties of a wide range of nanoscale architectures together with their nanostructures and will enable the development of new (bio-)nanotechnology.

  3. Alternate gradient focusing and deceleration of a molecular beam

    International Nuclear Information System (INIS)

    Neutral dipolar molecules can be decelerated and trapped using time-varying inhomogeneous electric fields. This has been demonstrated only for molecules in low-field seeking states, but can, in principle, be performed on molecules in high-field seeking states as well. Transverse stability is then much more difficult to obtain, however, since molecules in high-field seeking states always experience a force towards the electrodes. Here we demonstrate that an array of dipole lenses in alternate gradient configuration can be used to maintain transverse stability. A pulsed beam of metastable CO in high-field seeking states is accelerated from 275 to 289 m/s as well as decelerated from 275 to 260 m/s

  4. Recuperation of data node: An alternative way to ensure the data recovery in Hadoop architecture.

    Directory of Open Access Journals (Sweden)

    P.Sai Kiran

    2015-03-01

    Full Text Available Hadoop is a software framework that supports data intensive distributed application. Hadoop creates clusters of machine and coordinates the work among them. It include two major component, HDFS (Hadoop Distributed File System and MapReduce. HDFS is designed to store large amount of data reliably and provide high availability of data to user application running at client. It creates multiple data blocks and store each of the block redundantly across the pool of servers to enable reliable, extreme rapid computation. MapReduce is software framework for the analyzing and transforming a very large data set in to desired output. This paper focus on how the data can be recovered by a variation in the architecture ensuring the continuation of computing if the DataNode fails.

  5. Alternative Radioligands for Investigating the Molecular Pharmacology of Melatonin Receptors.

    Science.gov (United States)

    Legros, Céline; Brasseur, Chantal; Delagrange, Philippe; Ducrot, Pierre; Nosjean, Olivier; Boutin, Jean A

    2016-03-01

    Melatonin exerts a variety of physiologic activities that are mainly relayed through the melatonin receptors MT1 and MT2 Low expressions of these receptors in tissues have led to widespread experimental use of the agonist 2-[(125)I]-iodomelatonin as a substitute for melatonin. We describe three iodinated ligands: 2-(2-[(2-iodo-4,5-dimethoxyphenyl)methyl]-4,5-dimethoxy phenyl) (DIV880) and (2-iodo-N-2-[5-methoxy-2-(naphthalen-1-yl)-1H-pyrrolo[3,2-b]pyridine-3-yl])acetamide (S70254), which are specific ligands at MT2 receptors, and N-[2-(5-methoxy-1H-indol-3-yl)ethyl]iodoacetamide (SD6), an analog of 2-[(125)I]-iodomelatonin with slightly different characteristics. Here, we further characterized these new ligands with regards to their molecular pharmacology. We performed binding experiments, saturation assays, association/dissociation rate measurements, and autoradiography using sheep and rat tissues and recombinant cell lines. Our results showed that [(125)I]-S70254 is receptor, and can be used with both cells and tissue. This radioligand can be used in autoradiography. Similarly, DIV880, a partial agonist [43% of melatonin on guanosine 5'-3-O-(thio)triphosphate binding assay], selective for MT2, can be used as a tool to selectively describe the pharmacology of this receptor in tissue samples. The molecular pharmacology of both human melatonin receptors MT1 and MT2, using a series of 24 ligands at these receptors and the new radioligands, did not lead to noticeable variations in the profiles. For the first time, we described radiolabeled tools that are specific for one of the melatonin receptors (MT2). These tools are amenable to binding experiments and to autoradiography using sheep or rat tissues. These specific tools will permit better understanding of the role and implication in physiopathologic processes of the melatonin receptors. PMID:26759496

  6. Architecture-Level Exploration of Alternative Interconnection Schemes Targeting 3D FPGAs: A Software-Supported Methodology

    Directory of Open Access Journals (Sweden)

    Kostas Siozios

    2008-01-01

    Full Text Available In current reconfigurable architectures, the interconnection structures increasingly contribute more to the delay and power consumption. The demand for increased clock frequencies and logic density (smaller area footprint makes the problem even more important. Three-dimensional (3D architectures are able to alleviate this problem by accommodating a number of functional layers, each of which might be fabricated in different technology. However, the benefits of such integration technology have not been sufficiently explored yet. In this paper, we propose a software-supported methodology for exploring and evaluating alternative interconnection schemes for 3D FPGAs. In order to support the proposed methodology, three new CAD tools were developed (part of the 3D MEANDER Design Framework. During our exploration, we study the impact of vertical interconnection between functional layers in a number of design parameters. More specifically, the average gains in operation frequency, power consumption, and wirelength are 35%, 32%, and 13%, respectively, compared to existing 2D FPGAs with identical logic resources. Also, we achieve higher utilization ratio for the vertical interconnections compared to existing approaches by 8% for designing 3D FPGAs, leading to cheaper and more reliable devices.

  7. Thermosensitive PNIPAM-b-HTPB block copolymer micelles: molecular architectures and camptothecin drug release.

    Science.gov (United States)

    Luo, Yan-Ling; Yang, Xiao-Li; Xu, Feng; Chen, Ya-Shao; Zhang, Bin

    2014-02-01

    Two kinds of thermo-sensitive poly(N-isoproplacrylamide) (PNIPAM) block copolymers, AB4 four-armed star multiblock and linear triblock copolymers, were synthesized by ATRP with hydroxyl-terminated polybutadiene (HTPB) as central blocks, and characterization was performed by (1)H NMR, FT-IR and SEC. The multiblock copolymers could spontaneously assemble into more regular spherical core-shell nanoscale micelles than the linear triblock copolymer. The physicochemical properties were detected by a surface tension technique, nano particle analyzer, TEM, DLS and UV-vis measurements. The multiblock copolymer micelles had lower critical micelle concentration than the linear counterpart, TEM size from 100 to 120 nm and the hydrodynamic diameters below 150 nm. The micelles exhibited thermo-dependent size change, with low critical solution temperature about 33-35 °C. The characteristic parameters were affected by the composition ratios, length of PNIPAM blocks and molecular architectures. The camptothecin release demonstrated that the drug release was thermo-responsive, accompanied by the temperature-induced structural changes of the micelles. MTT assays were performed to evaluate the biocompatibility or cytotoxicity of the prepared copolymer micelles. PMID:24184534

  8. Molecular mechanisms of activity and derepression of alternative lengthening of telomeres.

    Science.gov (United States)

    Pickett, Hilda A; Reddel, Roger R

    2015-11-01

    Alternative lengthening of telomeres (ALT) involves homology-directed telomere synthesis. This multistep process is facilitated by loss of the ATRX or DAXX chromatin-remodeling factors and by abnormalities of the telomere nucleoprotein architecture, including altered DNA sequence and decreased TRF2 saturation. Induction of telomere-specific DNA damage triggers homology-directed searches, and NuRD-ZNF827 protein-protein interactions provide a platform for the telomeric recruitment of homologous recombination (HR) proteins. Telomere lengthening proceeds by strand exchange and template-driven DNA synthesis, which culminates in dissolution of HR intermediates. PMID:26581522

  9. How Different Molecular Architectures Influence the Dynamics of H-Bonded Structures in Glass-Forming Monohydroxy Alcohols.

    Science.gov (United States)

    Wikarek, M; Pawlus, S; Tripathy, Satya N; Szulc, A; Paluch, M

    2016-06-30

    Primary alcohols have been an active area of research since the beginning of the 20th century. The main problem in studying monohydroxy alcohols is the molecular origin of the slower Debye relaxation, whereas the faster process, recognized as structural relaxation, remains much less investigated. This is because in many primary alcohols the structural process is strongly overlapped by the dominating Debye relaxation. Additionally, there is still no answer for many fundamental questions concerning the origin of the molecular characteristic properties of these materials. One of them is the role of molecular architecture in the formation of hydrogen-bonded structures and its potential connection to the relaxation dynamics of Debye and structural relaxation processes. In this article, we present the results of ambient and high-pressure dielectric studies of monohydroxy alcohols with similar chemical structures but different carbon chain lengths (2-ethyl-1-butanol and 2-ethyl-1-hexanol) and positions of the OH- group (2-methyl-2-hexanol and 2-methyl-3-hexanol). New data are compared with previously collected results for 5-methyl-2-hexanol. We note that differences in molecular architecture have a significant influence on the formation of hydrogen-bonded structures, which is reflected in the behavior of the Debye and structural relaxation processes. Intriguingly, studying the relaxation dynamics in monohydroxy alcohols at high pressures of up to p = 1700 MPa delivers a fundamental bridge to understand the potential connection between molecular conformation and its response to the characteristic properties of these materials. PMID:27254726

  10. Molecular architecture of nanocapsules, bilayer-enclosed solid particles of Cisplatin.

    Science.gov (United States)

    Chupin, Vladimir; de Kroon, Anton I P M; de Kruijff, Ben

    2004-10-27

    Cisplatin nanocapsules represent a lipid formulation of the anticancer drug cis-diamminedichloroplatinum(II) (cisplatin) characterized by an unprecedented cisplatin-to-lipid ratio and exhibiting strongly improved cytotoxicity against tumor cells in vitro as compared to the free drug (Burger, K. N. J., et al. Nat. Med. 2002, 8, 81-84). Cisplatin nanocapsules are prepared by the repeated freezing and thawing of an equimolar dispersion of phosphatidylserine (PS) and phosphatidylcholine (PC) in a concentrated aqueous solution of cisplatin. Here, the molecular architecture of these novel nanostructures was elucidated by solid-state NMR techniques. 15N NMR and 2H NMR spectra of nanocapsules containing 15N- and 2H-labeled cisplatin, respectively, demonstrated that the core of the nanocapsules consists of solid cisplatin devoid of free water. Magic-angle spinning 15N NMR showed that approximately 90% of the cisplatin in the core is present as the dichloro species. The remaining 10% was accounted for by a newly discovered dinuclear Pt compound that was identified as the positively charged chloride-bridged dimer of cisplatin. NMR techniques sensitive to lipid organization, 31P NMR and 2H NMR, revealed that the cisplatin core is coated by phospholipids in a bilayer configuration and that the interaction between solid core and bilayer coat exerts a strong ordering effect on the phospholipid molecules. Compared to phospholipids in liposomal membranes, the motion of the phospholipid headgroups is restricted and the ordering of the acyl chains is increased, particularly in PS. The implications of these findings for the structural organization, the mechanism of formation, and the mode of action of cisplatin nanocapsules are discussed. PMID:15493941

  11. Faults architecture and growth in clay-limestone alternation. Examples in the S-E Basin alternations (France) and numerical modeling

    International Nuclear Information System (INIS)

    The following work has been carried out in the framework of the studies conducted by IRSN in support of its safety evaluation of the geological disposal programme of high and intermediate level, long-lived radioactive waste. Such a disposal is planned to be hosted by the Callovian-Oxfordian indurate clay formation between two limestone formations in eastern Paris basin, France. Hypothetical faults may cross-cut this layered section, decreasing the clay containment ability by creating preferential pathways for radioactive solute towards limestones. This study aims at characterising the fault architecture and the normal fault growth in clay/limestone layered sections. Structural analysis and displacement profiles have been carried out in normal faults crossing several decimetres to metre thick sedimentary alternations in the South-Eastern Basin (France) and petrophysical properties have been determined for each layer. The studied faults are simple fault planes or complex fault zones showing are significantly controlled by the layering. The analysis of the fault characteristics and the results obtained on numerical models enlighten several processes such as fault nucleation, fault restriction, and fault growth through layered section. Some studied faults nucleated in the limestone layers, without using pre-existing fractures such as joints, and according to our numerical analysis, a strong stiffness, a low strength contrast between the limestone and the clay layer, and/or s a greater thickness of the clay layer are conditions which favour nucleation of faults in limestone. The range of mechanical properties leading to the fault nucleation in one layer type or another was investigated using a 3D modelling approach. After its nucleation, the fault propagates within a homogeneous medium with a constant displacement gradient until its vertical propagation is stopped by a restrictor. The evidenced restrictors are limestone-clay interfaces or faults in clays, sub

  12. Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

    OpenAIRE

    Muntoni, Alessandra; Neumann, Axel A.; Hills, Mark; Reddel, Roger R

    2008-01-01

    Alternative lengthening of telomeres (ALT) is a telomere length maintenance mechanism based on recombination, where telomeres use other telomeric DNA as a template for DNA synthesis. About 10% of all human tumors depend on ALT for their continued growth, and understanding its molecular details is critically important for the development of cancer treatments that target this mechanism. We have previously shown that telomeres of ALT-positive human cells can become lengthened via inter-telomeric...

  13. Effect of chain architecture on the size, shape, and intrinsic viscosity of chains in polymer solutions: A molecular simulation study

    Science.gov (United States)

    Khabaz, Fardin; Khare, Rajesh

    2014-12-01

    Effect of chain architecture on the chain size, shape, and intrinsic viscosity was investigated by performing molecular dynamics simulations of polymer solutions in a good solvent. Four types of chains - linear, comb shaped, H-shaped, and star - were studied for this purpose using a model in which the solvent particles were considered explicitly. Results indicated that the chain length (N) dependence of the mean squared radius of gyration of the chains followed a power-law behavior intrinsic viscosity of the chains can be calculated by plotting the specific viscosity determined from simulations against the solution concentration. The intrinsic viscosity exhibited linear behavior with the reciprocal of the overlap concentration for all chain architectures studied. The molecular weight dependence of the intrinsic viscosity followed the Mark-Houwink relation, [η] = KMa, for all chain architectures. When comparing the calculated values of exponent a with the literature experimental values, agreement was found only for the H and star chains, and a disagreement for the linear and comb chains. The viscosity shrinking factor of the branched chains was compared with the available experimental data and the theoretical predictions and a general agreement was found.

  14. Self-assembly, redox activity, and charge transport of functional surface nano-architectures by molecular design

    Science.gov (United States)

    Skomski, Daniel

    Surface-assisted molecular self-assembly is a promising strategy to program the structure and chemical state of atoms and molecules in nano-architectures to achieve a specific function. The experiments described in this thesis demonstrate that the design and programming of basic organic components leads to desired characteristics by self-assembly. The fabrication of uniform single-site metal centers at surfaces, important for high selectivity in next-generation catalysts, was accomplished by coordination to redox non-innocent phenanthroline and tetrazine-based ligands. These examples were the first demonstrating tuning of the metal oxidation state in surface coordination architectures through rational ligand design. The molecular-scale coordination architectures were the first formed from chromium and vanadium, and the first from platinum in a non-porphyrin system. The first mixed valence metal-ligand surface structure was fabricated that attained the same ligand coordination number for all metal sites. A new surface reaction method was demonstrated between an inexpensive sodium chloride reagent and carboxylate ligands. High-temperature, molecular-resolution microscopy and spectroscopy of the ordered metal-organic structures demonstrated thermal stability up to 300 °C, the highest molecular-level thermal stability in organic surface nanostructures yet achieved, making such systems potential candidates for moderate-temperature catalytic reactions. Molecular self-assembly was expanded into organic semiconductor thin films. In a two-component, bi-layered system, hydrogen bonding between carboxylates and carboxylic acid-substituted thiophenes was utilized, yielding the first real-space images of phenyl-thiophene stacking. In a one-component system, multiple donor-acceptor pi-pi contacts between phenyltriazole building blocks accomplished assembly of flat-lying molecules from a surface with molecular-scale precision through more than twenty molecular layers. Sufficient

  15. Software Architecture Simulation

    OpenAIRE

    Mårtensson, Frans; Jönsson, Per

    2002-01-01

    A software architecture is one of the first steps towards a software system. A software architecture can be designed in different ways. During the design phase, it is important to select the most suitable design of the architecture, in order to create a good foundation for the system. The selection process is performed by evaluating architecture alternatives against each other. We investigate the use of continuous simulation of a software architecture as a support tool for architecture evalua...

  16. Architecture and data processing alternatives for Tse computer. Volume 1: Tse logic design concepts and the development of image processing machine architectures

    Science.gov (United States)

    Rickard, D. A.; Bodenheimer, R. E.

    1976-01-01

    Digital computer components which perform two dimensional array logic operations (Tse logic) on binary data arrays are described. The properties of Golay transforms which make them useful in image processing are reviewed, and several architectures for Golay transform processors are presented with emphasis on the skeletonizing algorithm. Conventional logic control units developed for the Golay transform processors are described. One is a unique microprogrammable control unit that uses a microprocessor to control the Tse computer. The remaining control units are based on programmable logic arrays. Performance criteria are established and utilized to compare the various Golay transform machines developed. A critique of Tse logic is presented, and recommendations for additional research are included.

  17. Architecture-Level Exploration of Alternative Interconnection Schemes Targeting 3D FPGAs: A Software-Supported Methodology

    OpenAIRE

    Dimitrios Soudris; Alexandros Bartzas; Kostas Siozios

    2008-01-01

    In current reconfigurable architectures, the interconnection structures increasingly contribute more to the delay and power consumption. The demand for increased clock frequencies and logic density (smaller area footprint) makes the problem even more important. Three-dimensional (3D) architectures are able to alleviate this problem by accommodating a number of functional layers, each of which might be fabricated in different technology. However, the benefits of such integration technology hav...

  18. Glossary of class names of polymers based on chemical structure and molecular architecture (IUPAC Recommendations 2009)

    Czech Academy of Sciences Publication Activity Database

    Baron, M.; Hellwich, K. H.; Hess, M.; Horie, K.; Jenkins, A.D.; Jones, R. G.; Kahovec, Jaroslav; Kratochvíl, Pavel; Metanomski, W. V.; Mormann, W.; Stepto, R. F. T.; Vohlídal, J.; Wilks, E. S.

    2009-01-01

    Roč. 81, č. 6 (2009), s. 1131-1183. ISSN 0033-4545 R&D Projects: GA MŠk(CZ) LA09028 Keywords : IUPAC Polymer Division * macromolecule architecture * polymer class names Subject RIV: CD - Macromolecular Chemistry Impact factor: 2.289, year: 2009

  19. Process evaluation of an open architecture real-time molecular laboratory platform.

    Science.gov (United States)

    Felder, Robin A; Jackson, Keith D; Walter, Adam M

    2014-10-01

    The needs of molecular diagnostic laboratories that perform both Food and Drug Administration-cleared as well as laboratory-developed tests are usually not met on a single analytical platform. Furthermore, little information is available about the direct impact of molecular automation on labor costs and efficiency in clinical laboratories. We performed a process impact analysis from time and motion studies of a novel molecular diagnostic robotic system designed to automate sample preparation, extraction, and analysis. All 27 preanalytical tasks were quantified for the amount of time spent preparing 24 specimens for analysis. These steps were completed in 899 s (14 min, 59 s) followed by 7887 s (131 min, 27 s) of instrument operation independent of operator control (walk-away time). Postanalytical results evaluation required 1 min per specimen. The instrument automatically extracted the nucleic acid from the specimen, added the eluted DNA to the amplification reagents, and performed the analysis. Only 12% of the total instrument operations required relatively unskilled human labor. Thus, the availability of automated molecular diagnostic instruments will facilitate the expansion of molecular testing in the clinical laboratory because they reduce operator costs with respect to time and complexity of the tasks they are asked to perform. PMID:24811476

  20. Architecture of transcriptional regulatory circuits is knitted over the topology of bio-molecular interaction networks

    DEFF Research Database (Denmark)

    Soberano de Oliveira, Ana Paula; Patil, Kiran Raosaheb; Nielsen, Jens

    2008-01-01

    use the topology of bio-molecular interaction networks in order to constrain the solution space. Such approaches systematically integrate the existing biological knowledge with the 'omics' data. Results: Here we introduce a hypothesis-driven method that integrates bio-molecular network topology with...... transcriptome data, thereby allowing the identification of key biological features (Reporter Features) around which transcriptional changes are significantly concentrated. We have combined transcriptome data with different biological networks in order to identify Reporter Gene Ontologies, Reporter Transcription...... Factors, Reporter Proteins and Reporter Complexes, and use this to decipher the logic of regulatory circuits playing a key role in yeast glucose repression and human diabetes. Conclusion: Reporter Features offer the opportunity to identify regulatory hot-spots in bio-molecular interaction networks that...

  1. Design of two-photon molecular tandem architectures for solar cells by ab initio theory

    DEFF Research Database (Denmark)

    Ørnsø, Kristian Baruël; García Lastra, Juan Maria; De La Torre, Gema;

    2015-01-01

    structural and energetic properties of several thousand porphyrin dyes. The third design is a molecular analogy of the intermediate band solar cell, and involves a single dye molecule with strong intersystem crossing to ensure a long lifetime of the intermediate state. Based on the calculated energy levels...

  2. Advances of Molecular Imaging for Monitoring the Anatomical and Functional Architecture of the Olfactory System.

    Science.gov (United States)

    Zhang, Xintong; Bi, Anyao; Gao, Quansheng; Zhang, Shuai; Huang, Kunzhu; Liu, Zhiguo; Gao, Tang; Zeng, Wenbin

    2016-01-20

    The olfactory system of organisms serves as a genetically and anatomically model for studying how sensory input can be translated into behavior output. Some neurologic diseases are considered to be related to olfactory disturbance, especially Alzheimer's disease, Parkinson's disease, multiple sclerosis, and so forth. However, it is still unclear how the olfactory system affects disease generation processes and olfaction delivery processes. Molecular imaging, a modern multidisciplinary technology, can provide valid tools for the early detection and characterization of diseases, evaluation of treatment, and study of biological processes in living subjects, since molecular imaging applies specific molecular probes as a novel approach to produce special data to study biological processes in cellular and subcellular levels. Recently, molecular imaging plays a key role in studying the activation of olfactory system, thus it could help to prevent or delay some diseases. Herein, we present a comprehensive review on the research progress of the imaging probes for visualizing olfactory system, which is classified on different imaging modalities, including PET, MRI, and optical imaging. Additionally, the probes' design, sensing mechanism, and biological application are discussed. Finally, we provide an outlook for future studies in this field. PMID:26616533

  3. Prediction and experimental characterization of the molecular architecture of FRP and ATRP synthesized polyacrylate networks

    OpenAIRE

    Gonçalves, Miguel; Dias, Rolando; Costa, Mário Rui

    2010-01-01

    This work reports experimental and modeling studies concerning the conventional (FRP) and atom transfer radical polymerization (ATRP) of acrylate/diacrylate monomers. In the framework of a recently developed general approach, kinetic models including crosslinking reactions and branching by chain transfer to polymer are discussed for FRP and ATRP polymerization systems. Besides molecular weight distribution (MWD), fairly good predictions of the z-average radius of gyration could be obtained fo...

  4. Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters

    Science.gov (United States)

    Gorbunov, Dmitry; Sturlese, Mattia; Nies, Florian; Kluge, Murielle; Bellanda, Massimo; Battistutta, Roberto; Oliver, Dominik

    2014-04-01

    Prestin (SLC26A5) is a member of the SLC26/SulP anion transporter family. Its unique quasi-piezoelectric mechanical activity generates fast cellular motility of cochlear outer hair cells, a key process underlying active amplification in the mammalian ear. Despite its established physiological role, it is essentially unknown how prestin can generate mechanical force, since structural information on SLC26/SulP proteins is lacking. Here we derive a structural model of prestin and related transporters by combining homology modelling, MD simulations and cysteine accessibility scanning. Prestin’s transmembrane core region is organized in a 7+7 inverted repeat architecture. The model suggests a central cavity as the substrate-binding site located midway of the anion permeation pathway, which is supported by experimental solute accessibility and mutational analysis. Anion binding to this site also controls the electromotile activity of prestin. The combined structural and functional data provide a framework for understanding electromotility and anion transport by SLC26 transporters.

  5. Measurement of Small Molecular Dopant F4TCNQ and C60F36 Diffusion in Organic Bilayer Architectures.

    Science.gov (United States)

    Li, Jun; Rochester, Chris W; Jacobs, Ian E; Friedrich, Stephan; Stroeve, Pieter; Riede, Moritz; Moulé, Adam J

    2015-12-30

    The diffusion of molecules through and between organic layers is a serious stability concern in organic electronic devices. In this work, the temperature-dependent diffusion of molecular dopants through small molecule hole transport layers is observed. Specifically we investigate bilayer stacks of small molecules used for hole transport (MeO-TPD) and p-type dopants (F4TCNQ and C60F36) used in hole injection layers for organic light emitting diodes and hole collection electrodes for organic photovoltaics. With the use of absorbance spectroscopy, photoluminescence spectroscopy, neutron reflectometry, and near-edge X-ray absorption fine structure spectroscopy, we are able to obtain a comprehensive picture of the diffusion of fluorinated small molecules through MeO-TPD layers. F4TCNQ spontaneously diffuses into the MeO-TPD material even at room temperature, while C60F36, a much bulkier molecule, is shown to have a substantially higher morphological stability. This study highlights that the differences in size/geometry and thermal properties of small molecular dopants can have a significant impact on their diffusion in organic device architectures. PMID:26673846

  6. A nematode microtubule-associated protein, PTL-1, closely resembles its mammalian counterparts in overall molecular architecture.

    Science.gov (United States)

    Hashi, Yurika; Kotani, Susumu; Adachi, Takeshi

    2016-06-01

    The mammalian microtubule-associated proteins (MAPs), MAP2, MAP4, and τ, are structurally similar and considered to be evolutionarily related. The primary structure of a nematode MAP, PTL-1, also reportedly resembles those of the MAPs, but only in a small portion of the molecule. In this study, we elucidated the overall domain organization of PTL-1, using a molecular dissection technique. Firstly, we isolated nematode microtubules and proved that the recombinant PTL-1 binds to nematode and porcine microtubules with similar affinities. Then, the recombinant PTL-1 was genetically dissected to generate four shorter polypeptides, and their microtubule-binding and assembly promoting activities were assessed, using porcine microtubules and tubulin. PTL-1 was found to consist of two parts, microtubule-binding and projection domains, with the former further divided into three functionally distinct subdomains. The molecular architecture of PTL-1 was proved to be quite analogous to its mammalian counterparts, MAP2, MAP4, and τ, strongly supporting their evolutionary relationships. PMID:26906882

  7. Quantitative Framework to Evaluate Alternative Dispute Resolution Investments in Architecture Engineering and Construction Projects Using Option and Real Option Theory

    Science.gov (United States)

    Menassa, Carol Chukri

    2009-01-01

    A project-specific dispute resolution ladder (DRL) typically consists of multiple alternative dispute resolution (ADR) techniques that are chosen to assist in mitigating the impact of change orders and claims (CCO) occurring during the project construction phase, and avoid their escalation to protracted disputes that adversely affect a…

  8. Immobilized High Level Waste (HLW) Interim Storage Alternative Generation and analysis and Decision Report 2nd Generation Implementing Architecture

    Energy Technology Data Exchange (ETDEWEB)

    CALMUS, R.B.

    2000-09-14

    Two alternative approaches were previously identified to provide second-generation interim storage of Immobilized High-Level Waste (IHLW). One approach was retrofit modification of the Fuel and Materials Examination Facility (FMEF) to accommodate IHLW. The results of the evaluation of the FMEF as the second-generation IHLW interim storage facility and subsequent decision process are provided in this document.

  9. Molecular biological approach to study genetic architecture of the genus Ipomoea

    International Nuclear Information System (INIS)

    The most significant obstacles in sweet potato breeding are the self- and cross-incompatibilities. It has made cross breeding and genetic analysis very difficult, besides the problems of polyploidy. Recent development of molecular analysis techniques made some of the genetic analyses possible. In this paper, (1) the phylogenetic relations of sweet potato cultivars and their wild relatives are clarified by the use of RFLP analysis and (2) the nature of a cDNA clone specific for pollen and stigma are reported. (author). 16 refs, 7 figs, 2 tabs

  10. Two different coordination dimers of pyromellitic acid in terms of molecular geometry and supramolecular architecture

    Science.gov (United States)

    Aycan, Tuğba Ak; Paşaoğlu, Hümeyra; Kaştaş, Gökhan

    2016-02-01

    Two mixed-ligand coordination dimers, [Ni2(pm) (ina)2(H2O)4] (1) and [Mn2(Hpm)2(ina)2(H2O)2]·H2O (2) (pm = tetraanion of pyromellitic acid, Hpm = trianion of pyromellitic acid and ina = isonicotinamide), were comparatively investigated by focusing on their supramolecular architectures. Their structural properties were characterized by X-ray diffraction technique (XRD) and Fourier transform infrared spectroscopy (FT-IR). In 1, each pm4- anion adopts μ2-bridging mode to connect two Ni(II) ions through carboxylate groups while in 2 Hpm3- anion bridges Mn(II) ions with tridentate coordination mode of carboxylate groups in cis positions. In 1, 1D H-bonded linear chain consists of R22(8) synthons. Linear chains are inter-connected by O-H⋯O bonds with DA:AD type organization of aqua ligands, resulting in R42(8) synthons to form 2D structure. The increase in the dimensionality of the network is achieved by the involvement of aqua ligands in H-bonds with DD:AA fashion. In 2, the amide group of ina ligand and the aqua ligand involve in DD:AA type H-bond with COO- group of Hpm3- in the formation of ribbon structure. The ribbon structures are inter-connected by H-bonds between the aqua ligands and carboxylate groups, forming 2D supramolecular sheet through R12(4) synthons. Unlike the case of 1, the pyridinium plays an important role to form 3D network of 2 by connecting 2D sheets through R22(22) and R44(30) synthons. The FT-IR investigation of the complexes was performed within the mid-IR region, mainly focusing on the characteristic vibrations of pyromellitic acid and isonicotinamide moieties by considering their free states and ligand behavior in the case of complex formation.

  11. Extension of the AMBER molecular dynamics software to Intel's Many Integrated Core (MIC) architecture

    Science.gov (United States)

    Needham, Perri J.; Bhuiyan, Ashraf; Walker, Ross C.

    2016-04-01

    We present an implementation of explicit solvent particle mesh Ewald (PME) classical molecular dynamics (MD) within the PMEMD molecular dynamics engine, that forms part of the AMBER v14 MD software package, that makes use of Intel Xeon Phi coprocessors by offloading portions of the PME direct summation and neighbor list build to the coprocessor. We refer to this implementation as pmemd MIC offload and in this paper present the technical details of the algorithm, including basic models for MPI and OpenMP configuration, and analyze the resultant performance. The algorithm provides the best performance improvement for large systems (>400,000 atoms), achieving a ∼35% performance improvement for satellite tobacco mosaic virus (1,067,095 atoms) when 2 Intel E5-2697 v2 processors (2 ×12 cores, 30M cache, 2.7 GHz) are coupled to an Intel Xeon Phi coprocessor (Model 7120P-1.238/1.333 GHz, 61 cores). The implementation utilizes a two-fold decomposition strategy: spatial decomposition using an MPI library and thread-based decomposition using OpenMP. We also present compiler optimization settings that improve the performance on Intel Xeon processors, while retaining simulation accuracy.

  12. Amphiphilic, hydrophilic, or hydrophobic synthetic bacteriochlorins in biohybrid light-harvesting architectures: consideration of molecular designs.

    Science.gov (United States)

    Jiang, Jianbing; Reddy, Kanumuri Ramesh; Pavan, M Phani; Lubian, Elisa; Harris, Michelle A; Jiao, Jieying; Niedzwiedzki, Dariusz M; Kirmaier, Christine; Parkes-Loach, Pamela S; Loach, Paul A; Bocian, David F; Holten, Dewey; Lindsey, Jonathan S

    2014-11-01

    Biohybrid light-harvesting architectures can be constructed that employ native-like bacterial photosynthetic antenna peptides as a scaffold to which synthetic chromophores are attached to augment overall spectral coverage. Synthetic bacteriochlorins are attractive to enhance capture of solar radiation in the photon-rich near-infrared spectral region. The effect of the polarity of the bacteriochlorin substituents on the antenna self-assembly process was explored by the preparation of a bacteriochlorin-peptide conjugate using a synthetic amphiphilic bacteriochlorin (B1) to complement prior studies using hydrophilic (B2, four carboxylic acids) or hydrophobic (B3) bacteriochlorins. The amphiphilic bioconjugatable bacteriochlorin B1 with a polar ammonium-terminated tail was synthesized by sequential Pd-mediated reactions of a 3,13-dibromo-5-methoxybacteriochlorin. Each bacteriochlorin bears a maleimido-terminated tether for attachment to a cysteine-containing analog of the Rhodobacter sphaeroides antenna β-peptide to give conjugates β-B1, β-B2, and β-B3. Given the hydrophobic nature of the β-peptide, the polarity of B1 and B2 facilitated purification of the respective conjugate compared to the hydrophobic B3. Bacteriochlorophyll a (BChl a) associates with each conjugate in aqueous micellar media to form a dyad containing two β-peptides, two covalently attached synthetic bacteriochlorins, and a datively bonded BChl-a pair, albeit to a limited extent for β-B2. The reversible assembly/disassembly of dyad (β-B2/BChl)2 was examined in aqueous detergent (octyl glucoside) solution by temperature variation (15-35 °C). The energy-transfer efficiency from the synthetic bacteriochlorin to the BChl-a dimer was found to be 0.85 for (β-B1/BChl)2, 0.40 for (β-B2/BChl)2, and 0.85 for (β-B3/BChl)2. Thus, in terms of handling, assembly and energy-transfer efficiency taken together, the amphiphilic design examined herein is more attractive than the prior hydrophilic or

  13. Alternative basis functions for L2 calculations on the molecular continuum. I. The basic prototype integrals

    International Nuclear Information System (INIS)

    Alternative square-integrable (L2) basis functions, the oscillating Hermite Gaussian functions (OHGF's), are proposed for describing the continuum orbitals in L2 calculations on molecules. Each function is the product of a Hermite Gaussian function (HGF), which gives the proper dumping and angular factor, and a radial trigonometric function, cos(kr), which describes the oscillating asymptotic behavior of a continuum orbital. Analytic expressions for the one- and two-electron integrals involving s-type OHGF's and many-center s-type HGF's are derived and their numerical implementation is discussed in detail. The present proposal of adopting a mixed basis set of OHGF's and many-center HGF's for the L2 description of bound and continuum molecular states is compared with the other types of basis functions currently employed. With respect to these, it requires a greater computational effort in the integral evaluation, but it also allows an accurate description of the electronic continuum in general polyatomic systems

  14. Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system

    Science.gov (United States)

    Lacin, Haluk; Truman, James W

    2016-01-01

    Neurogenesis in Drosophila occurs in two phases, embryonic and post-embryonic, in which the same set of neuroblasts give rise to the distinct larval and adult nervous systems, respectively. Here, we identified the embryonic neuroblast origin of the adult neuronal lineages in the ventral nervous system via lineage-specific GAL4 lines and molecular markers. Our lineage mapping revealed that neurons born late in the embryonic phase show axonal morphology and transcription factor profiles that are similar to the neurons born post-embryonically from the same neuroblast. Moreover, we identified three thorax-specific neuroblasts not previously characterized and show that HOX genes confine them to the thoracic segments. Two of these, NB2-3 and NB3-4, generate leg motor neurons. The other neuroblast is novel and appears to have arisen recently during insect evolution. Our findings provide a comprehensive view of neurogenesis and show how proliferation of individual neuroblasts is dictated by temporal and spatial cues. DOI: http://dx.doi.org/10.7554/eLife.13399.001 PMID:26975248

  15. Molecular protein adaptor with genetically encoded interaction sites guiding the hierarchical assembly of plasmonically active nanoparticle architectures

    Science.gov (United States)

    Schreiber, Andreas; Huber, Matthias C.; Cölfen, Helmut; Schiller, Stefan M.

    2015-03-01

    The control over the defined assembly of nano-objects with nm-precision is important to create systems and materials with enhanced properties, for example, metamaterials. In nature, the precise assembly of inorganic nano-objects with unique features, for example, magnetosomes, is accomplished by efficient and reliable recognition schemes involving protein effectors. Here we present a molecular approach using protein-based ‘adaptors/connectors’ with genetically encoded interaction sites to guide the assembly and functionality of different plasmonically active gold nanoparticle architectures (AuNP). The interaction of the defined geometricaly shaped protein adaptors with the AuNP induces the self-assembly of nanoarchitectures ranging from AuNP encapsulation to one-dimensional chain-like structures, complex networks and stars. Synthetic biology and bionanotechnology are applied to co-translationally encode unnatural amino acids as additional site-specific modification sites to generate functionalized biohybrid nanoarchitectures. This protein adaptor-based nano-object assembly approach might be expanded to other inorganic nano-objects creating biohybrid materials with unique electronic, photonic, plasmonic and magnetic properties.

  16. Platelet responses to dynamic biomaterial surfaces with different poly(ethylene glycol) and polyrotaxane molecular architectures constructed on gold substrates.

    Science.gov (United States)

    Kakinoki, Sachiro; Yui, Nobuhiko; Yamaoka, Tetsuji

    2013-11-01

    Four different dynamic biomaterial surfaces with different molecular architectures were prepared using two hydrophilic polymers: poly(ethylene glycol) and polyrotaxanes containing α-cyclodextrin. Either one or both terminals of the poly(ethylene glycol) or polyrotaxanes were immobilized onto a gold substrate via Au-S bonds, resulting in poly(ethylene glycol)-graft, polyrotaxanes-graft, poly(ethylene glycol)-loop, and polyrotaxanes-loop structures. Human platelet adhesion was suppressed more effectively on the graft surfaces than on the loop surfaces for both poly(ethylene glycol) and polyrotaxanes due to the high mobility of graft polymer chains with a free terminal. Moreover, the platelets adhered to the polyrotaxane surfaces much less than the poly(ethylene glycol) surfaces, possibly because of the mobile nature of the α-cyclodextrin molecules that were threaded on the poly(ethylene glycol) chain. Actin filament assembly in adherent platelets was also greatly prevented on the poly(ethylene glycol)/polyrotaxanes-graft surfaces in comparison with the corresponding loop surfaces. A clear correlation between the numbers and areas of adherent platelets on these surfaces suggests that platelet adhesion and activation were dominated by the platelet GPIIb/IIIa-adsorbed fibrinogen interaction. These results indicate that both of the different modes of dynamic features, sliding/rotation of α-cyclodextrin and polymer chain mobility, effectively suppressed platelet adhesion in spite of the similar hydrophilicity. This research affords a novel chemical strategy for designing hemocompatible biomaterial surfaces. PMID:23048065

  17. An alternating copolymer of maleimide and atropic acid with narrow molecular weight distribution prepared by radical mechanism

    Institute of Scientific and Technical Information of China (English)

    万德成; 黄兆华; 黄骏廉

    1999-01-01

    Three basic conditions for preparation of alternating copolymer with narrow molecular weight distribution were derived from the element kinetic equations of binary radical copolymerization. Using maleimide (MI) and atropie acid (ATA) as model monomer pairs and dioxane as the solvent the alternating copolymer with molecular weight distribution in the range of 1.09--1.20 was prepared successfully by charger transfer complex (CTC) mechanism in the presence of benzoyl peroxide at 85℃. The monomer reactivity ratioes r1(MI)=0.05±0.01 and r2(ATA)=0.03±0.02 were measured. The alternating eopolymerization was carried out through formation of a contact-type CTG and then alternating addition of MI and ATA monomers. The molecular weight of the copolymers is nearly independent of the feed ratio in a large range and the polymerization rate dropped with an increase in ATA in feed ratio.

  18. Software Architecture: Architecture Constraints

    OpenAIRE

    Tibermacine, Chouki

    2014-01-01

    International audience In this chapter, we introduce an additional, yet essential, concept in describing software architectures : architecture constraints. We explain the precise role of these entities and their importance in object-oriented, component-based or service-oriented software engi-neering. We then describe the way in which they are specified and interpreted. An architect can define architecture constraints and then associate them to architectural descriptions to limit their stru...

  19. Architecture on Architecture

    DEFF Research Database (Denmark)

    Olesen, Karen

    2016-01-01

    how recognising the autonomy of architecture, not as an esoteric concept but as a valid source of information in a pragmatic design practice, may help us overcome the often-proclaimed dichotomy between formal autonomy and a societally committed architecture. It follows that in architectural education...

  20. An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model

    OpenAIRE

    McCrae, Robert R.; Scally, Matthew; Terracciano, Antonio; Abecasis, Gonçalo R; Costa, Paul T.

    2010-01-01

    There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely-unsuccessful search for individual polymorphisms associated with personality traits, we identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two-thirds of a large (N = 3,972) sample of individuals from Sar...

  1. Synthesis and characterization of liquid-crystalline supramolecular architecture by a combination of molecular recognition and polymerization reaction

    Science.gov (United States)

    Ahn, Cheol-Hee

    In nature, self-assembly with well defined shapes obtained from combinations of polymeric building blocks with complex architecture are abundant since they are responsible for the production of structural materials and for the generation of some of the most efficient mechanisms. One of the many roles liquid crystallinity plays in natural systems is in their self-assembly and organization. The assembly of these complex natural systems is largely under thermodynamic control which is manipulated by their liquid crystallinity. The goal of this thesis is to use Nature as a model for the development of new synthetic concepts and strategies in the field of polymer science. The two models selected are rod-like and icosahedral viruses. The strategy involved in this thesis requires the design of libraries of monodendritic building blocks with well defined flat tapered and conical shapes which self-assemble into cylindrical and respectively spherical shapes. By analogy with viruses these supermolecules will generated hexagonal columnar and spherical cubic thermotropic phases. These liquid crystalline phases allow the determination of their shape by X-ray diffraction and Scanning Force Microscopy. Libraries of flat tapered and conical monodendritic building blocks will be functionalized with polymerizable groups and polymerized to generate the first examples of polymers of cylindrical and spherical shapes with diameter and length, and diameter controlled at the nanoscale level. The organization of these dendritic monomers in a liquid crystalline assembly is also used to aggregate their polymerizable groups in a reactor of artificially enhanced concentration and restricted geometry during the polymerization process and therefore, generate a new approach to the control of polymerization. The resulting liquid crystallinity provides access to the thermodynamically controlled assembly and characterization of these newly developed polymers. With few exceptions, there is no precedent

  2. Architecture on Architecture

    DEFF Research Database (Denmark)

    Olesen, Karen

    2016-01-01

    This paper will discuss the challenges faced by architectural education today. It takes as its starting point the double commitment of any school of architecture: on the one hand the task of preserving the particular knowledge that belongs to the discipline of architecture, and on the other hand...... the obligation to prepare students to perform in a profession that is largely defined by forces outside that discipline. It will be proposed that the autonomy of architecture can be understood as a unique kind of information: as architecture’s self-reliance or knowledge-about itself. A knowledge that...... is not scientific or academic but is more like a latent body of data that we find embedded in existing works of architecture. This information, it is argued, is not limited by the historical context of the work. It can be thought of as a virtual capacity – a reservoir of spatial configurations that...

  3. Architecture of Burkholderia cepacia complex σ70 gene family: evidence of alternative primary and clade-specific factors, and genomic instability

    Directory of Open Access Journals (Sweden)

    Menard Aymeric

    2007-09-01

    Full Text Available Abstract Background The Burkholderia cepacia complex (Bcc groups bacterial species with beneficial properties that can improve crop yields or remediate polluted sites but can also lead to dramatic human clinical outcomes among cystic fibrosis (CF or immuno-compromised individuals. Genome-wide regulatory processes of gene expression could explain parts of this bacterial duality. Transcriptional σ70 factors are components of these processes. They allow the reversible binding of the DNA-dependent RNA polymerase to form the holoenzyme that will lead to mRNA synthesis from a DNA promoter region. Bcc genome-wide analyses were performed to investigate the major evolutionary trends taking place in the σ70 family of these bacteria. Results Twenty σ70 paralogous genes were detected in the Burkholderia cenocepacia strain J2315 (Bcen-J2315 genome, of which 14 were of the ECF (extracytoplasmic function group. Non-ECF paralogs were related to primary (rpoD, alternative primary, stationary phase (rpoS, flagellin biosynthesis (fliA, and heat shock (rpoH factors. The number of σ70 genetic determinants among this genome was of 2,86 per Mb. This number is lower than the one of Pseudomonas aeruginosa, a species found in similar habitats including CF lungs. These two bacterial groups showed strikingly different σ70 family architectures, with only three ECF paralogs in common (fecI-like, pvdS and algU. Bcen-J2315 σ70 paralogs showed clade-specific distributions. Some paralogs appeared limited to the ET12 epidemic clone (ecfA2, particular Bcc species (sigI, the Burkholderia genus (ecfJ, ecfF, and sigJ, certain proteobacterial groups (ecfA1, ecfC, ecfD, ecfE, ecfG, ecfL, ecfM and rpoS, or were broadly distributed in the eubacteria (ecfI, ecfK, ecfH, ecfB, and rpoD-, rpoH-, fliA-like genes. Genomic instability of this gene family was driven by chromosomal inversion (ecfA2, recent duplication events (ecfA and RpoD, localized (ecfG and large scale deletions (sig

  4. Molecular and Cellular Evidence for the Alternative Lengthening of Telomeres (ALT) Mechanism in Chicken

    OpenAIRE

    O'Hare, T.H.; Delany, M. E.

    2011-01-01

    Telomere maintenance is an important genetic mechanism controlling cellular proliferation. Normally, telomeres are maintained by telomerase which is downregulated upon cellular differentiation in most somatic cell lineages. Telomerase activity is upregulated in immortalized cells and cancers to support an infinite lifespan and uncontrolled cell growth; however, some immortalized and transformed cells lack telomerase activity. Telomerase-negative tumors and immortalized cells utilize an altern...

  5. Parasite histories and novel phylogenetic tools: alternative approaches to inferring parasite evolution from molecular markers

    Czech Academy of Sciences Publication Activity Database

    Hypša, Václav

    2006-01-01

    Roč. 36, č. 2 (2006), s. 141-155. ISSN 0020-7519 R&D Projects: GA ČR GA206/04/0520 Institutional research plan: CEZ:AV0Z60220518 Keywords : molecular phylogeny * parasite evolution Subject RIV: EE - Microbiology, Virology Impact factor: 3.337, year: 2006

  6. Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma.

    Science.gov (United States)

    Di Martino, Maria Teresa; Guzzi, Pietro Hiram; Caracciolo, Daniele; Agnelli, Luca; Neri, Antonino; Walker, Brian A; Morgan, Gareth J; Cannataro, Mario; Tassone, Pierfrancesco; Tagliaferri, Pierosandro

    2015-08-01

    Multiple Myeloma (MM) is a malignancy characterized by the hyperdiploid (HD-MM) and the non-hyperdiploid (nHD-MM) subtypes. To shed light within the molecular architecture of these subtypes, we used a novel integromics approach. By annotated MM patient mRNA/microRNA (miRNA) datasets, we investigated mRNAs and miRNAs profiles with relation to changes in transcriptional regulators expression. We found that HD-MM displays specific gene and miRNA expression profiles, involving the Signal Transducer and Activator of Transcription (STAT)3 pathway as well as the Transforming Growth Factor-beta (TGFβ) and the transcription regulator Nuclear Protein-1 (NUPR1). Our data define specific molecular features of HD-MM that may translate in the identification of novel relevant druggable targets. PMID:26056083

  7. Molecular rheology of branched polymers: Decoding and exploring the role of architectural dispersity through a synergy of anionic synthesis, interaction chromatography, rheometry and modeling

    KAUST Repository

    Van Ruymbeke, Evelyne

    2014-01-01

    An emerging challenge in polymer physics is the quantitative understanding of the influence of a macromolecular architecture (i.e., branching) on the rheological response of entangled complex polymers. Recent investigations of the rheology of well-defined architecturally complex polymers have determined the composition in the molecular structure and identified the role of side-products in the measured samples. The combination of different characterization techniques, experimental and/or theoretical, represents the current state-of-the-art. Here we review this interdisciplinary approach to molecular rheology of complex polymers, and show the importance of confronting these different tools for ensuring an accurate characterization of a given polymeric sample. We use statistical tools in order to relate the information available from the synthesis protocols of a sample and its experimental molar mass distribution (typically obtained from size exclusion chromatography), and hence obtain precise information about its structural composition, i.e. enhance the existing sensitivity limit. We critically discuss the use of linear rheology as a reliable quantitative characterization tool, along with the recently developed temperature gradient interaction chromatography. The latter, which has emerged as an indispensable characterization tool for branched architectures, offers unprecedented sensitivity in detecting the presence of different molecular structures in a sample. Combining these techniques is imperative in order to quantify the molecular composition of a polymer and its consequences on the macroscopic properties. We validate this approach by means of a new model asymmetric comb polymer which was synthesized anionically. It was thoroughly characterized and its rheology was carefully analyzed. The main result is that the rheological signal reveals fine molecular details, which must be taken into account to fully elucidate the viscoelastic response of entangled branched

  8. The Molecular Immunology of Mucositis: Implications for Evidence-Based Research in Alternative and Complementary Palliative Treatments

    Directory of Open Access Journals (Sweden)

    Francesco Chiappelli

    2005-01-01

    Full Text Available The terms ‘mucositis’ and ‘stomatitis’ are often used interchangeably. Mucositis, however, pertains to pharyngeal-esophago-gastrointestinal inflammation that manifests as red, burn-like sores or ulcerations throughout the mouth. Stomatitis is an inflammation of the oral tissues proper, which can present with or without sores, and is made worse by poor dental hygiene. Mucositis is observed in a variety of immunosuppressed patients, but is most often consequential to cancer therapy. It appears as early as the third day of intervention, and is usually established by Day 7 of treatment. Mucositis increases mortality and morbidity and contributes to rising health care costs. The precise immune components involved in the etiology of mucositis are unclear, but evidence-based research (EBR data has shown that applications of granulocyte–macrophage-colony stimulating factor prevent the onset or the exacerbation of oropharyngeal mucositis. The molecular implications of this observation are discussed from the perspective of future developments of complementary and alternative treatments for this condition. It must be emphasized that this article is meant to be neither a review on mucositis and the various treatments for it, nor a discussion paper on its underlying molecular immunology. It is a statement of the implications of EBR for CAM-based interventions for mucositis. It explores and discusses the specific domain of molecular immunology in the context of mucositis and its direct implications for EBR research in CAM-based treatments for mucositis.

  9. Boronate Affinity-Molecularly Imprinted Biocompatible Probe: An Alternative for Specific Glucose Monitoring.

    Science.gov (United States)

    Chen, Guosheng; Qiu, Junlang; Fang, Xu'an; Xu, Jianqiao; Cai, Siying; Chen, Qing; Liu, Yan; Zhu, Fang; Ouyang, Gangfeng

    2016-08-19

    A biocompatible probe for specific glucose recognition is based on photoinitiated boronate affinity-molecular imprinted polymers (BA-MIPs). The unique pre-self-assembly between glucose and boronic acids creates glucose-specific memory cavities in the BA-MIPs coating. As a result, the binding constant toward glucose was enhanced by three orders of magnitude. The BA-MIPs probe was applied to glucose determination in serum and urine and implanted into plant tissues for low-destructive and long-term in vivo continuous glucose monitoring. PMID:27411946

  10. Visualizing Cell Architecture and Molecular Location Using Soft X-Ray Tomography and Correlated Cryo-Light Microscopy

    OpenAIRE

    McDermott, Gerry; Le Gros, Mark A.; Larabell, Carolyn A.

    2012-01-01

    Living cells are structured to create a range of microenvironments that support specific chemical reactions and processes. Understanding how cells function therefore requires detailed knowledge of both the subcellular architecture and the location of specific molecules within this framework. Here we review the development of two correlated cellular imaging techniques that fulfill this need. Cells are first imaged using cryogenic fluorescence microscopy to determine the location of molecules o...

  11. Microprobing the Molecular Spatial Distribution and Structural Architecture of Feed-type Sorghum Seed Tissue (Sorghum Bicolor L.) using the Synchrotron Radiation Infrared Microspectroscopy Technique

    International Nuclear Information System (INIS)

    Sorghum seed (Sorghum bicolor L.) has unique degradation and fermentation behaviours compared with other cereal grains such as wheat, barley and corn. This may be related to its cell and cell-wall architecture. The advanced synchrotron radiation infrared microspectroscopy (SR-IMS) technique enables the study of cell or living cell biochemistry within cellular dimensions. The objective of this study was to use the SR-IMS imaging technique to microprobe molecular spatial distribution and cell architecture of the sorghum seed tissue comprehensively. High-density mapping was carried out using SR-IMS on beamline U2B at the National Synchrotron Light Source (Brookhaven National Laboratory, NY, USA). Molecular images were systematically recorded from the outside to the inside of the seed tissue under various chemical functional groups and their ratios [peaks at ∼1725 (carbonyl C=O ester), 1650 (amide I), 1657 (protein secondary structure α-helix), 1628 (protein secondary structure β-sheet), 1550 (amide II), 1515 (aromatic compounds of lignin), 1428, 1371, 1245 (cellulosic compounds in plant seed tissue), 1025 (non-structural CHO, starch granules), 1246 (cellulosic material), 1160 (CHO), 1150 (CHO), 1080 (CHO), 930 (CHO), 860 (CHO), 3350 (OH and NH stretching), 2960 (CH3 anti-symmetric), 2929 (CH2 anti-symmetric), 2877 (CH3 symmetric) and 2848 cm-1 (CH2 asymmetric)]. The relative protein secondary structure α-helix to β-sheet ratio image, protein amide I to starch granule ratio image, and anti-symmetric CH3 to CH2 ratio image were also investigated within the intact sorghum seed tissue. The results showed unique cell architecture, and the molecular spatial distribution and intensity in the sorghum seed tissue (which were analyzed through microprobe molecular imaging) were generated using SR-IMS. This imaging technique and methodology has high potential and could be used for scientists to develop specific cereal grain varieties with targeted food and feed quality, and

  12. Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin

    DEFF Research Database (Denmark)

    Maric, Hans-Michael; Kasaragod, Vikram Babu; Hausrat, Torben Johann;

    2014-01-01

    γ-Aminobutyric acid type A and glycine receptors (GABA(A)Rs, GlyRs) are the major inhibitory neurotransmitter receptors and contribute to many synaptic functions, dysfunctions and human diseases. GABA(A)Rs are important drug targets regulated by direct interactions with the scaffolding protein...... gephyrin. Here we deduce the molecular basis of this interaction by chemical, biophysical and structural studies of the gephyrin-GABA(A)R α3 complex, revealing that the N-terminal region of the α3 peptide occupies the same binding site as the GlyR β subunit, whereas the C-terminal moiety, which is...... conserved among all synaptic GABA(A)R α subunits, engages in unique interactions. Thermodynamic dissections of the gephyrin-receptor interactions identify two residues as primary determinants for gephyrin's subunit preference. This first structural evidence for the gephyrin-mediated synaptic accumulation of...

  13. An alternative derivation of ring-polymer molecular dynamics transition-state theory

    CERN Document Server

    Hele, Timothy J H

    2016-01-01

    In a previous article [J. Chem. Phys. 138, 084108 (2013)], we showed that the transition-state-theory ($t\\rightarrow 0_+$) limit of ring-polymer molecular dynamics rate-theory (RPMD-TST) is also the $t\\rightarrow 0_+$ limit of a new type of quantum flux-side time-correlation function, in which the dividing surfaces are invariant to imaginary-time translation; in other words, that RPMD-TST is a $t\\rightarrow 0_+$ quantum transition-state theory (QTST). Recently, Jang and Voth [J. Chem. Phys. 144, 084110 (2016)] rederived this quantum $t\\rightarrow 0_+$ limit, and claimed that it gives instead the centroid-density approximation. Here we show that the $t\\rightarrow 0_+$ limit derived by Jang and Voth is in fact RPMD-TST.

  14. An alternative derivation of ring-polymer molecular dynamics transition-state theory

    Science.gov (United States)

    Hele, Timothy J. H.; Althorpe, Stuart C.

    2016-05-01

    In a previous article [T. J. H. Hele and S. C. Althorpe, J. Chem. Phys. 138, 084108 (2013)], we showed that the t → 0+ limit of ring-polymer molecular dynamics (RPMD) rate-theory is also the t → 0+ limit of a new type of quantum flux-side time-correlation function, in which the dividing surfaces are invariant to imaginary-time translation; in other words, that RPMD transition-state theory (RMPD-TST) is a t → 0+ quantum transition-state theory (QTST). Recently, Jang and Voth [J. Chem. Phys. 144, 084110 (2016)] rederived this quantum t → 0+ limit and claimed that it gives instead the centroid-density approximation. Here we show that the t → 0+ limit derived by Jang and Voth is in fact RPMD-TST.

  15. Multiple expression of molecular information: enforced generation of different supramolecular inorganic architectures by processing of the same ligand information through specific coordination algorithms

    Science.gov (United States)

    Funeriu; Lehn; Fromm; Fenske

    2000-06-16

    The multisubunit ligand 2 combines two complexation substructures known to undergo, with specific metal ions, distinct self-assembly processes to form a double-helical and a grid-type structure, respectively. The binding information contained in this molecular strand may be expected to generate, in a strictly predetermined and univocal fashion, two different, well-defined output inorganic architectures depending on the set of metal ions, that is, on the coordination algorithm used. Indeed, as predicted, the self-assembly of 2 with eight CuII and four CuI yields the intertwined structure D1. It results from a crossover of the two assembly subprograms and has been fully characterized by crystal structure determination. On the other hand, when the instructions of strand 2 are read out with a set of eight CuI and four MII (M = Fe, Co, Ni, Cu) ions, the architectures C1-C4, resulting from a linear combination of the two subprograms, are obtained, as indicated by the available physico-chemical and spectral data. Redox interconversion of D1 and C4 has been achieved. These results indicate that the same molecular information may yield different output structures depending on how it is processed, that is, depending on the interactional (coordination) algorithm used to read it. They have wide implications for the design and implementation of programmed chemical systems, pointing towards multiprocessing capacity, in a one code/ several outputs scheme, of potential significance for molecular computation processes and possibly even with respect to information processing in biology. PMID:10926214

  16. Molecular cloning and functional characterization of a mouse gene upregulated by lipopolysaccharide treatment reveals alternative splicing

    International Nuclear Information System (INIS)

    Treatment of mouse cells with lipopolysaccharide (LPS) potently initiates an inflammatory response, but the underlying mechanisms are unclear. We therefore sought to characterize cDNA sequences of a new mouse LPS-responsive gene, and to evaluate the effects of MLrg. Full-length cDNAs were obtained from LPS-treated NIH3T3 cells. We report that the MLrg gene produces two alternative splice products (GenBank Accession Nos. (DQ316984) and (DQ320011)), respectively, encoding MLrgW and MLrgS polypeptides. Both proteins contain zinc finger and leucine zipper domains and are thus potential regulators of transcription. Expression of MLrgW and MLrgS were robustly upregulated following LPS treatment, and the proteins were localized predominantly in the nuclear membrane and cytoplasm. In stable transfectants over-expressing MLrgW the proportion of cells in G1 phase was significantly reduced, while in cells over-expressing MLrgS the proportion of cells in G2 was significantly increased; both proteins are thus potential regulators of cell cycle progression. Upregulation of MLrgW and MLrgS may be an important component of the LPS inflammatory pathway and of the host response to infection with GNB.

  17. Alternative splicing modulates Kv channel clustering through a molecular ball and chain mechanism

    Science.gov (United States)

    Zandany, Nitzan; Marciano, Shir; Magidovich, Elhanan; Frimerman, Teddy; Yehezkel, Rinat; Shem-Ad, Tzilhav; Lewin, Limor; Abdu, Uri; Orr, Irit; Yifrach, Ofer

    2015-03-01

    Ion channel clustering at the post-synaptic density serves a fundamental role in action potential generation and transmission. Here, we show that interaction between the Shaker Kv channel and the PSD-95 scaffold protein underlying channel clustering is modulated by the length of the intrinsically disordered C terminal channel tail. We further show that this tail functions as an entropic clock that times PSD-95 binding. We thus propose a ‘ball and chain’ mechanism to explain Kv channel binding to scaffold proteins, analogous to the mechanism describing channel fast inactivation. The physiological relevance of this mechanism is demonstrated in that alternative splicing of the Shaker channel gene to produce variants of distinct tail lengths resulted in differential channel cell surface expression levels and clustering metrics that correlate with differences in affinity of the variants for PSD-95. We suggest that modulating channel clustering by specific spatial-temporal spliced variant targeting serves a fundamental role in nervous system development and tuning.

  18. Architectural Slicing

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2013-01-01

    Architectural prototyping is a widely used practice, con- cerned with taking architectural decisions through experiments with light- weight implementations. However, many architectural decisions are only taken when systems are already (partially) implemented. This is prob- lematic in the context of...... architectural prototyping since experiments with full systems are complex and expensive and thus architectural learn- ing is hindered. In this paper, we propose a novel technique for harvest- ing architectural prototypes from existing systems, \\architectural slic- ing", based on dynamic program slicing. Given a...... system and a slicing criterion, architectural slicing produces an architectural prototype that contain the elements in the architecture that are dependent on the ele- ments in the slicing criterion. Furthermore, we present an initial design and implementation of an architectural slicer for Java....

  19. Near-microsecond human aquaporin 4 gating dynamics in static and alternating external electric fields: Non-equilibrium molecular dynamics.

    Science.gov (United States)

    English, Niall J; Garate, José-A

    2016-08-28

    An extensive suite of non-equilibrium molecular-dynamics simulation has been performed for ∼0.85-0.9 μs of human aquaporin 4 in the absence and presence of externally applied static and alternating electric fields applied along the channels (in both axial directions in the static case, taken as the laboratory z-axis). These external fields were of 0.0065 V/Å (r.m.s.) intensity (of the same order as physiological electrical potentials); alternating fields ranged in frequency from 2.45 to 500 GHz. In-pore gating dynamics was studied, particularly of the relative propensities for "open" and "closed" states of the conserved arginines in the arginine/aromatic area (itself governed in no small part by external-field response of the dipolar alignment of the histidine-201 residue in the selectivity filter). In such a manner, the intimate connection of field-response governing "two-state" histidine states was established statistically and mechanistically. Given the appreciable size of the energy barriers for histidine-201 alignment, we have also performed non-equilibrium metadynamics/local-elevation of static fields applied along both directions to construct the free-energy landscape thereof in terms of external-field direction, elucidating the importance of field direction on energetics. We conclude from direct measurement of deterministic molecular dynamics in conjunction with applied-field metadynamics that the intrinsic electric field within the channel points along the +z-axis, such that externally applied static fields in this direction serve to "open" the channel in the selectivity-filter and the asparagine-proline-alanine region. PMID:27586951

  20. Molecular analysis of human argininosuccinate lyase: Mutant characterization and alternative splicing of the coding region

    International Nuclear Information System (INIS)

    Argininosuccinic acid lyase (ASAL) deficiency is a clinically heterogeneous autosomal recessive urea cycle disorder. The authors previously established by complementation analysis that 29 ASAL-deficient patients have heterogeneous mutations in a single gene. To prove that the ASAL structural gene is the affected locus, they sequenced polymerase chain reaction-amplified ASAL cDNA of a representative mutant from the single complementation group. Fibroblast strain 944 from a late-onset patient who was the product of a consanguineous mating, had only a single base-pair change in the coding region, a C-283→ T transition at a CpG dinucleotide in exon 3. This substitution converts Arg-95 to Cys (R95C), occurs in a stretch of 13 residues that is identical in yeast and human ASAL, and was present in both of the patient's alleles but not in 14 other mutant or 10 normal alleles. They observed that amplified cDNA from mutant 944 and normal cells (liver, keratinocytes, lymphoblasts, and fibroblasts) contained, in addition to the expected 5' 513-base-pair band, a prominent 318-base-pair ASAL band formed by the splicing of exon 2 from the transcript. The short transcript maintains the ASAL reading frame but removes Lys-51, a residue that may be essential for catalysis, since it binds the argininosuccinate substrate. They conclude (i) that the identification of the R95C mutation in strain 944 demonstrates that virtually all ASAL deficiency results from defects in the ASAL structural gene and (ii) that minor alternative splicing of the coding region occurs at the ASAL locus

  1. Early Fear Memory Defects Are Associated with Altered Synaptic Plasticity and Molecular Architecture in the TgCRND8 Alzheimer's Disease Mouse Model

    Science.gov (United States)

    Steele, John W.; Brautigam, Hannah; Short, Jennifer A.; Sowa, Allison; Shi, Mengxi; Yadav, Aniruddha; Weaver, Christina M.; Westaway, David; Fraser, Paul E.; St George-Hyslop, Peter H.; Gandy, Sam; Hof, Patrick R.; Dickstein, Dara L.

    2014-01-01

    Alzheimer's disease (AD) is a complex and slowly progressing dementing disorder that results in neuronal and synaptic loss, deposition in brain of aberrantly folded proteins, and impairment of spatial and episodic memory. Most studies of mouse models of AD have employed analyses of cognitive status and assessment of amyloid burden, gliosis, and molecular pathology during disease progression. Here, we sought to understand the behavioral, cellular, ultrastructural, and molecular changes that occur at a pathological stage equivalent to early stages of human AD. We studied the TgCRND8 mouse, a model of aggressive AD amyloidosis, at an early stage of plaque pathology (3 months of age) in comparison to their wild-type littermates and assessed changes in cognition, neuron and spine structure, and expression of synaptic glutamate receptor proteins. We found that, at this age, TgCRND8 mice display substantial plaque deposition in the neocortex and hippocampus and impairment on cued and contextual memory tasks. Of particular interest, we also observed a significant decrease in the number of neurons in the hippocampus. Furthermore, analysis of CA1 neurons revealed significant changes in apical and basal dendritic spine types, as well as altered expression of GluN1 and GluA2 receptors. This change in molecular architecture within the hippocampus may reflect a rising representation of inherently less stable thin spine populations, which can cause cognitive decline. These changes, taken together with toxic insults from amyloid-β protein, may underlie the observed neuronal loss. PMID:24415002

  2. Miscanthus plants used as an alternative biofuel material. The basic studies on ecology and molecular evolution

    Energy Technology Data Exchange (ETDEWEB)

    Chou, Chang-Hung [Graduate Institute of Ecology and Evolutionary Biology, College of Life Sciences, China Medical University, Taichung 404 (China)

    2009-08-15

    Miscanthus Anderss, widely distributed in Asia and Pacific Islands, possesses 20 species. Of which 8 species and 1 variety were recorded in Chinese Mainland; 6 species and 1 variety found in Japan; 5 species and 3 varieties distributed in Taiwan; 3 species documented in the Philippines; and rest of species have been recorded in Jawa, eastern Himalaya, and Sikkim. The plant is a C{sub 4} perennial grass with high productivity of biomass. In the 19th and early 20th centuries in Taiwan, Miscanthus was a very important crop used for forage grass, clothing, and shelter, etc. The relatively high germination, and high yield of biomass made the plant available for people of Taiwan including aboriginal. The taxonomic study of Miscanthus plants was much done by several scientists, and its ecological study has been only taken by the present author since 1972. Chou and his associates paid a great attention to elucidate the mechanism of dominance of Miscanthus vegetation and found that allelopathy plays an important role. In addition, the population biology of Miscanthus taxa by using polyacrylamide gel electrophoreses technique to examine the patterns of peroxidase and esterase among populations (over 100) of Miscanthus in Taiwan were conducted. They also elucidated the phylogenetic relationship among species and varieties in Taiwan. Chou and Ueng proposed an evolutionary trend of Miscanthus species, indicating that the Miscanthus sinensis was assumed to be the origin of Miscanthus Anderss, which evolved to M. sinensis var. formosana, and M. sinensis var. flavidus, and M. sinensis var. transmorrisonensis, and Miscanthus floridulus was thought to be an out group of M. sinensis complex. Moreover, molecular phylogeny was attempted to clarify the population heterogeneity of M. sinensis complex, resulting in a substantial information. It would be available for making hybridization between Miscanthus species and its related species, such as Saccharum (sugar cane) spp. which is a

  3. Visualizing Cell Architecture and Molecular Location Using Soft X-Ray Tomography and Correlated Cryo-Light Microscopy

    Science.gov (United States)

    McDermott, Gerry; Le Gros, Mark A.; Larabell, Carolyn A.

    2012-05-01

    Living cells are structured to create a range of microenvironments that support specific chemical reactions and processes. Understanding how cells function therefore requires detailed knowledge of both the subcellular architecture and the location of specific molecules within this framework. Here we review the development of two correlated cellular imaging techniques that fulfill this need. Cells are first imaged using cryogenic fluorescence microscopy to determine the location of molecules of interest that have been labeled with fluorescent tags. The same specimen is then imaged using soft X-ray tomography to generate a high-contrast, 3D reconstruction of the cells. Data from the two modalities are then combined to produce a composite, information-rich view of the cell. This correlated imaging approach can be applied across the spectrum of problems encountered in cell biology, from basic research to biotechnological and biomedical applications such as the optimization of biofuels and the development of new pharmaceuticals.

  4. G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system.

    Science.gov (United States)

    Brugarolas, Marc; Navarro, Gemma; Martínez-Pinilla, Eva; Angelats, Edgar; Casadó, Vicent; Lanciego, José L; Franco, Rafael

    2014-08-01

    The overall architecture of the nervous system, especially the CNS, is remarkable. The anatomy of the nervous system is constituted not only by macroscopic and microscopy identifiable regions and neuronal cell types, but also by protein complexes whose identification and localization require sophisticated techniques. G-protein-coupled receptors (GPCRs) constitute an example of proteins that are the key factors in the framework needed to sustain brain and nerve structure and function. The versatility underlying nervous system anatomy takes advantage of a recently discovered feature of GPCRs, the possibility to form heteromers that, placed at specific neuronal subsets and at specific locations (pre-, post-, or peri-synaptic), contribute to attain unique neural functions. PMID:24809909

  5. Molecular and Morpho-Agronomical Characterization of Root Architecture at Seedling and Reproductive Stages for Drought Tolerance in Wheat

    Science.gov (United States)

    Vinod; Naik, Bhojaraja K.; Chand, Suresh; Deshmukh, Rupesh; Mallick, Niharika; Singh, Sanjay; Singh, Nagendra Kumar; Tomar, S. M. S.

    2016-01-01

    Water availability is a major limiting factor for wheat (Triticum aestivum L.) production in rain-fed agricultural systems worldwide. Root architecture is important for water and nutrition acquisition for all crops, including wheat. A set of 158 diverse wheat genotypes of Australian (72) and Indian (86) origin were studied for morpho-agronomical traits in field under irrigated and drought stress conditions during 2010–11 and 2011-12.Out of these 31 Indian wheat genotypes comprising 28 hexaploid (Triticum aestivum L.) and 3 tetraploid (T. durum) were characterized for root traits at reproductive stage in polyvinyl chloride (PVC) pipes. Roots of drought tolerant genotypes grew upto137cm (C306) as compared to sensitive one of 63cm with a mean value of 94.8cm. Root architecture traits of four drought tolerant (C306, HW2004, HD2888 and NI5439) and drought sensitive (HD2877, HD2012, HD2851 and MACS2496) genotypes were also observed at 6 and 9 days old seedling stage. The genotypes did not show any significant variation for root traits except for longer coleoptiles and shoot and higher absorptive surface area in drought tolerant genotypes. The visible evaluation of root images using WinRhizo Tron root scanner of drought tolerant genotype HW2004 indicated compact root system with longer depth while drought sensitive genotype HD2877 exhibited higher horizontal root spread and less depth at reproductive stage. Thirty SSR markers were used to study genetic variation which ranged from 0.12 to 0.77 with an average value of 0.57. The genotypes were categorized into three subgroups as highly tolerant, sensitive, moderately sensitive and tolerant as intermediate group based on UPGMA cluster, STRUCTURE and principal coordinate analyses. The genotypic clustering was positively correlated to grouping based on root and morpho-agronomical traits. The genetic variability identified in current study demonstrated these traits can be used to improve drought tolerance and association

  6. Molecular and Morpho-Agronomical Characterization of Root Architecture at Seedling and Reproductive Stages for Drought Tolerance in Wheat.

    Science.gov (United States)

    Tomar, Ram Sewak Singh; Tiwari, Sushma; Vinod; Naik, Bhojaraja K; Chand, Suresh; Deshmukh, Rupesh; Mallick, Niharika; Singh, Sanjay; Singh, Nagendra Kumar; Tomar, S M S

    2016-01-01

    Water availability is a major limiting factor for wheat (Triticum aestivum L.) production in rain-fed agricultural systems worldwide. Root architecture is important for water and nutrition acquisition for all crops, including wheat. A set of 158 diverse wheat genotypes of Australian (72) and Indian (86) origin were studied for morpho-agronomical traits in field under irrigated and drought stress conditions during 2010-11 and 2011-12.Out of these 31 Indian wheat genotypes comprising 28 hexaploid (Triticum aestivum L.) and 3 tetraploid (T. durum) were characterized for root traits at reproductive stage in polyvinyl chloride (PVC) pipes. Roots of drought tolerant genotypes grew upto137cm (C306) as compared to sensitive one of 63cm with a mean value of 94.8cm. Root architecture traits of four drought tolerant (C306, HW2004, HD2888 and NI5439) and drought sensitive (HD2877, HD2012, HD2851 and MACS2496) genotypes were also observed at 6 and 9 days old seedling stage. The genotypes did not show any significant variation for root traits except for longer coleoptiles and shoot and higher absorptive surface area in drought tolerant genotypes. The visible evaluation of root images using WinRhizo Tron root scanner of drought tolerant genotype HW2004 indicated compact root system with longer depth while drought sensitive genotype HD2877 exhibited higher horizontal root spread and less depth at reproductive stage. Thirty SSR markers were used to study genetic variation which ranged from 0.12 to 0.77 with an average value of 0.57. The genotypes were categorized into three subgroups as highly tolerant, sensitive, moderately sensitive and tolerant as intermediate group based on UPGMA cluster, STRUCTURE and principal coordinate analyses. The genotypic clustering was positively correlated to grouping based on root and morpho-agronomical traits. The genetic variability identified in current study demonstrated these traits can be used to improve drought tolerance and association

  7. Formation of molecular clusters of selenium as an alternative to precipitation of CdSe nanoparticles in a borosilicate glass

    International Nuclear Information System (INIS)

    Solid-state precipitation in a borosilicate glass is a well-elaborated technique for obtaining II-VI semiconductor nanocrystals. The obtained nanocrystal size depends on the growth conditions (heat treatment temperature and duration). Here we present Raman evidence for an alternative process, precipitation of molecular clusters of selenium, which is also possible at certain growth conditions. Decoloured CdSe-doped borosilicate glass samples were subjected to thermal treatment at 625 to 700 C during 2 to 12 h. Resonant micro-Raman measurements were performed using a Dilor XY 800 spectrometer and different Ar+ laser lines for excitation. Besides the CdSe LO and 2LO phonon bands, the Raman spectra of the samples obtained at thermal treatment duration and temperature beyond the range, most suitable for the formation of CdSe nanocrystals, contained pronounced features at 323 and 646 cm-1. Based on their frequency positions, widths, intensities, and resonant behaviour, these features are attributed to Se2 clusters being formed in the glass during the thermal treatment.

  8. An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model

    Science.gov (United States)

    McCrae, Robert R.; Scally, Matthew; Terracciano, Antonio; Abecasis, Gonçalo R.; Costa, Paul T.

    2011-01-01

    There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely-unsuccessful search for individual polymorphisms associated with personality traits, we identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two-thirds of a large (N = 3,972) sample of individuals from Sardinia who completed the Revised NEO Personality Inventory and were assessed in a genome-wide association scan. When MPSs were correlated with the phenotype in the remaining third of the sample, very small but significant associations were found for four of the five personality factors when the longest scales were examined. These data suggest that MPSs for Neuroticism, Openness to Experience, Agreeableness, and Conscientiousness (but not Extraversion) contain genetic information that can be refined in future studies, and the procedures described here should be applicable to other quantitative traits. PMID:21114353

  9. An alternative to the search for single polymorphisms: toward molecular personality scales for the five-factor model.

    Science.gov (United States)

    McCrae, Robert R; Scally, Matthew; Terracciano, Antonio; Abecasis, Gonçalo R; Costa, Paul T

    2010-12-01

    There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two thirds of a large (N = 3,972) sample of individuals from Sardinia who completed the Revised NEO Personality Inventory (P. T. Costa, Jr., & R. R. McCrae, 1992) and were assessed in a genomewide association scan. When MPSs were correlated with the phenotype in the remaining one third of the sample, very small but significant associations were found for 4 of the 5e personality factors when the longest scales were examined. These data suggest that MPSs for Neuroticism, Openness to Experience, Agreeableness, and Conscientiousness (but not Extraversion) contain genetic information that can be refined in future studies, and the procedures described here should be applicable to other quantitative traits. PMID:21114353

  10. Metathesis of 1-octene over MoO3 supported on mesoporous molecular sieves: The influence of the support architecture

    Czech Academy of Sciences Publication Activity Database

    Topka, Pavel; Balcar, Hynek; Rathouský, Jiří; Žilková, Naděžda; Verpoort, F.; Čejka, Jiří

    2006-01-01

    Roč. 96, 1-3 (2006), s. 44-54. ISSN 1387-1811 R&D Projects: GA AV ČR IAA4040411; GA ČR GD203/03/H140 Grant ostatní: Bilateral Scientific Cooperation Flanders(CZ) 2004-2005-07 Institutional research plan: CEZ:AV0Z40400503 Keywords : metathesis * 1-octene * mesoporous molecular sieves * molybdenum oxide * Raman spectroscopy Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.796, year: 2006

  11. Architectural Contestation

    OpenAIRE

    Merle, J.

    2012-01-01

    This dissertation addresses the reductive reading of Georges Bataille's work done within the field of architectural criticism and theory which tends to set aside the fundamental ‘broken’ totality of Bataille's oeuvre and also to narrowly interpret it as a mere critique of architectural form, consequently presenting it either as the negation of all form of architecture or as the critique of 'classical' architectural forms. Against this ‘appropriation’, i.e. this reductive reading and the subse...

  12. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen; Fisker, Anna Marie; Kirkegaard, Poul Henning

    2013-01-01

    and recovery through the architecture framing eating experiences, this article examines, from a theoretical perspective, two less debated concepts relating to hospitality called food design and architectural theatricality. In architectural theory the nineteenth century German architect Gottfried...... Semper is known for his writings on theatricality, understood as a holistic design approach emphasizing the contextual, cultural, ritual and social meanings rooted in architecture. Relative hereto, the International Food Design Society recently argued, in a similar holistic manner, that the methodology...

  13. VLSI architecture

    Energy Technology Data Exchange (ETDEWEB)

    Randell, B.; Treleaven, P.C.

    1983-01-01

    This book is a collection of course papers which discusses the latest (1982) milestone of electronic building blocks and its effect on computer architecture. Contributions range from selecting a VLSI process technology to Japan's Fifth Generation Computer Architecture. Contents, abridged: VLSI and machine architecture. Graphic design aids: HED and FATFREDDY. On the LUCIFER system. Clocking of VLSI circuits. Decentralised computer architectures for VLSI. Index.

  14. Architecture & Environment

    Science.gov (United States)

    Erickson, Mary; Delahunt, Michael

    2010-01-01

    Most art teachers would agree that architecture is an important form of visual art, but they do not always include it in their curriculums. In this article, the authors share core ideas from "Architecture and Environment," a teaching resource that they developed out of a long-term interest in teaching architecture and their fascination with the…

  15. Tailoring two-dimensional PTCDA-melamine self-assembled architectures at room temperature by tuning molecular ratio

    Energy Technology Data Exchange (ETDEWEB)

    Sun Xiaonan; Jonkman, Harry T; Silly, Fabien, E-mail: fabien.silly@cea.fr [Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, NL-9747 AG Groningen (Netherlands)

    2010-04-23

    Engineering and tuning multi-component supramolecular self-assemblies on surfaces is one of the challenges of nanotechnology. We use scanning tunneling microscopy to investigate the influence of molecular ratio on the self-assembly of PTCDA-melamine structures on Au(111)-(22x{radical}3). Our observations reveal that three different chiral supramolecular networks having a PTCDA:melamine ratio of 3:2, 1:2, 1:4 can be selectively created by tuning the ratio of molecules deposited on the surface. The 1:2 ratio network having melamine in excess has been observed previously but the 1:4 network has not yet been reported. In comparison, the multi-component 3:2 network having PTCDA in excess is a completely new structure.

  16. Tailoring two-dimensional PTCDA-melamine self-assembled architectures at room temperature by tuning molecular ratio.

    Science.gov (United States)

    Sun, Xiaonan; Jonkman, Harry T; Silly, Fabien

    2010-04-23

    Engineering and tuning multi-component supramolecular self-assemblies on surfaces is one of the challenges of nanotechnology. We use scanning tunneling microscopy to investigate the influence of molecular ratio on the self-assembly of PTCDA-melamine structures on Au(111)-(22 x complex square root of 3). Our observations reveal that three different chiral supramolecular networks having a PTCDA:melamine ratio of 3:2, 1:2, 1:4 can be selectively created by tuning the ratio of molecules deposited on the surface. The 1:2 ratio network having melamine in excess has been observed previously but the 1:4 network has not yet been reported. In comparison, the multi-component 3:2 network having PTCDA in excess is a completely new structure. PMID:20348601

  17. Tailoring two-dimensional PTCDA-melamine self-assembled architectures at room temperature by tuning molecular ratio

    International Nuclear Information System (INIS)

    Engineering and tuning multi-component supramolecular self-assemblies on surfaces is one of the challenges of nanotechnology. We use scanning tunneling microscopy to investigate the influence of molecular ratio on the self-assembly of PTCDA-melamine structures on Au(111)-(22x√3). Our observations reveal that three different chiral supramolecular networks having a PTCDA:melamine ratio of 3:2, 1:2, 1:4 can be selectively created by tuning the ratio of molecules deposited on the surface. The 1:2 ratio network having melamine in excess has been observed previously but the 1:4 network has not yet been reported. In comparison, the multi-component 3:2 network having PTCDA in excess is a completely new structure.

  18. Adaptive Architectural Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Kirkegaard, Poul Henning

    2010-01-01

    Recent years have seen an increasing variety of applications of adaptive architectural structures for improvement of structural performance by recognizing changes in their environments and loads, adapting to meet goals, and using past events to improve future performance or maintain serviceability....... The general scopes of this paper are to develop a new adaptive kinetic architectural structure, particularly a reconfigurable architectural structure which can transform body shape from planar geometries to hyper-surfaces using different control strategies, i.e. a transformation into more than one or...... two different shape alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock- up...

  19. Architectural Prototyping in Industrial Practice

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2008-01-01

    Architectural prototyping is the process of using executable code to investigate stakeholders’ software architecture concerns with respect to a system under development. Previous work has established this as a useful and cost-effective way of exploration and learning of the design space of a system......, in addressing issues regarding quality attributes, in addressing architectural risks, and in addressing the problem of knowledge transfer and conformance. Little work has been reported so far on the actual industrial use of architectural prototyping. In this paper, we report from an ethnographical...... study and focus group involving architects from four companies in which we have focused on architectural prototypes. Our findings conclude that architectural prototypes play an important role in resolving problems experimentally, but less so in exploring alternative solutions. Furthermore, architectural...

  20. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    This PhD thesis is motived by a personal interest in the theoretical, practical and creative qualities of architecture. But also a wonder and curiosity about the cultural and social relations architecture represents through its occupation with both the sciences and the arts. Inspired by present...... initiatives in Aalborg Hospital to overcome patient undernutrition by refurbishing eating environments, this thesis engages in an investigation of the interior architectural qualities of patient eating environments. The relevance for this holistic perspective, synthesizing health, food and architecture, is...... the current building of a series of Danish ‘super hospitals’ and an increased focus among architectural practices on research-based knowledge produced with the architectural sub-disciplines Healing Architecture and Evidence-Based Design. The problem is that this research does not focus on patient...

  1. Molecular architecture of Pipistrellus pipistrellus/Pipistrellus pygmaeus complex (Chiroptera: Vespertilionidae): further cryptic species and Mediterranean origin of the divergence.

    Science.gov (United States)

    Hulva, Pavel; Horácek, Ivan; Strelkov, Petr P; Benda, Petr

    2004-09-01

    Previous genetic analyses have demonstrated that two phonic types of one of the most common European bats, the Common pipistrelle, belong to distinct species, although they are almost identical morphologically (45 kHz Pipistrellus pipistrellus and 55 kHz Pipistrellus pygmaeus). To reconstruct the history of the species complex and explain the codistribution of both forms in Europe and the Mediterranean, we performed phylogenetic analysis based on a 402-bp portion of the cytochrome b gene. Particular attention was paid to the eastern and southern parts of the range where no data were available. We found further distinctive allopatric haplotypes from Libya and Morocco. The difference of about 6-7% described in the Libyan population suggests the occurrence of a new species in the southern Mediterranean. The species status of Moroccan population is also discussed. The phylogeographic patterns obtained and analysis of fossil records support the hypothesis of expansion of both species into Europe from the Mediterranean region during the Holocene. The allopatric speciation model fits our data best. The paleobiographic scenario envisaged is corroborated also by molecular clock estimations and correlations with Late Neogene environmental changes in the Mediterranean region which ended with the Messinian salinity crisis. PMID:15288073

  2. Architectural freedom and industrialised architecture

    DEFF Research Database (Denmark)

    Vestergaard, Inge

    2012-01-01

    Architectural freedom and industrialized architecture. Inge Vestergaard, Associate Professor, Cand. Arch. Aarhus School of Architecture, Denmark Noerreport 20, 8000 Aarhus C Telephone +45 89 36 0000 E-mai l inge.vestergaard@aarch.dk Based on the repetitive architecture from the "building boom" 1960...... to 1973 it is discussed how architects can handle these Danish element and montage buildings through the transformation to upgraded aesthetical, functional and energy efficient architecture. The method used is analysis of cases, parallels to literature studies and producer interviews. This analysis...... compares "best practice" in Denmark and "best practice" in Austria. The modern architects accepted the fact that industrialized architecture told the storey of repetition and monotonous as basic condition. This article aims to explain that architecture can be thought as a complex and diverse design through...

  3. The Molecular Architecture for the Intermediate Filaments of Hard [alpha]-Keratin Based on the Superlattice Data Obtained from a Study ofMammals Using Synchrotron Fibre Diffraction

    Energy Technology Data Exchange (ETDEWEB)

    James, Veronica (ANU)

    2014-09-24

    High- and low-angle X-ray diffraction studies of hard {alpha}-keratin have been studied, and various models have been proposed over the last 70 years. Most of these studies have been confined to one or two forms of alpha keratin. This high- and low-angle synchrotron fibre diffraction study extends the study to cover all available data for all known forms of hard {alpha}-keratin including hairs, fingernails, hooves, horn, and quills from mammals, marsupials, and a monotreme, and it confirms that the model proposed is universally acceptable for all mammals. A complete Bragg analysis of the meridional diffraction patterns, including multiple-time exposures to verify any weak reflections, verified the existence of a superlattice consisting of two infinite lattices and three finite lattices. An analysis of the equatorial patterns establishes the radii of the oligomeric levels of dimers, tetramers, and intermediate filaments (IFs) together with the centre to centre distance for the IFs, thus confirming the proposed helices within helices molecular architecture for hard {alpha}-keratin. The results verify that the structure proposed by Feughelman and James meets the criteria for a valid {alpha}-keratin structure.

  4. Architecture Sustainability

    OpenAIRE

    Avgeriou, Paris; Stal, Michael; Hilliard, Rich

    2013-01-01

    Software architecture is the foundation of software system development, encompassing a system's architects' and stakeholders' strategic decisions. A special issue of IEEE Software is intended to raise awareness of architecture sustainability issues and increase interest and work in the area. The first Web extra at http://youtu.be/wUGHvocfix0 is an audio interview in which Davide Falessi speaks with guest editors Paris Avgeriou and Rich Hilliard about the importance of architecture sustainabil...

  5. Software architecture

    CERN Document Server

    Vogel, Oliver; Chughtai, Arif

    2011-01-01

    As a software architect you work in a wide-ranging and dynamic environment. You have to understand the needs of your customer, design architectures that satisfy both functional and non-functional requirements, and lead development teams in implementing the architecture. And it is an environment that is constantly changing: trends such as cloud computing, service orientation, and model-driven procedures open up new architectural possibilities. This book will help you to develop a holistic architectural awareness and knowledge base that extends beyond concrete methods, techniques, and technologi

  6. Catalyst Architecture

    DEFF Research Database (Denmark)

    Kiib, Hans; Marling, Gitte; Hansen, Peter Mandal

    2014-01-01

    How can architecture promote the enriching experiences of the tolerant, the democratic, and the learning city - a city worth living in, worth supporting and worth investing in? Catalyst Architecture comprises architectural projects, which, by virtue of their location, context and their combination...... of programs, have a role in mediating positive social and/or cultural development. In this sense, we talk about architecture as a catalyst for: sustainable adaptation of the city’s infrastructure appropriate renovation of dilapidated urban districts strengthening of social cohesiveness in the city...

  7. Selective IR multiphoton dissociation of molecules in a pulsed gas-dynamically cooled molecular flow interacting with a solid surface as an alternative to low-energy methods of molecular laser isotope separation

    Science.gov (United States)

    Makarov, G. N.; Petin, A. N.

    2016-03-01

    We report the results of studies on the isotope-selective infrared multiphoton dissociation (IR MFD) of SF6 and CF3I molecules in a pulsed, gas-dynamically cooled molecular flow interacting with a solid surface. The productivity of this method in the conditions of a specific experiment (by the example of SF6 molecules) is evaluated. A number of low-energy methods of molecular laser isotope separation based on the use of infrared lasers for selective excitation of molecules are analysed and their productivity is estimated. The methods are compared with those of selective dissociation of molecules in the flow interacting with a surface. The advantages of this method compared to the low-energy methods of molecular laser isotope separation and the IR MPD method in the unperturbed jets and flows are shown. It is concluded that this method could be a promising alternative to the low-energy methods of molecular laser isotope separation.

  8. Dextran sulphate: a synthetic activator of C3 via the alternative pathway. I. Influence of molecular size and degree of sulphation on the activation potency.

    Science.gov (United States)

    Burger, R; Hadding, U; Schorlemmer, H U; Brade, V; Bitter-Suermann, D

    1975-01-01

    The polyanion dextran sulphate (DS) triggers the alternative pathway of complement. The influence of the molecular weight and degree of sulphation on this potency was studied. The degree of substitution turned out to be the critical parameter for optimal C3 turnover: 60 SO4/100 glucose units (Glc) showed optimal activity; an increase up to 190 SO4/100 Glc did not increase the activation potency, while lowering the degree of sulphation diminished this activity. DS preparations (120 SO4/100 Glc) of molecular weight: 1 x 10(4); 8 x 10(4); 2-5 x 10(5); 2 x 10(6) were equally active; a DS of molecular weight 5 x 10(3) was inactive. These results indicate that above a critical molecular size (greater than 5 x 10(3)) only the degree of substitution is responsible for the C3 activating capacity. Clusters of several glucose residues each carrying one or two sulphate groups are thought to be the essential structure in DS for the activation of the alternative pathway. PMID:1172484

  9. Systemic Architecture

    DEFF Research Database (Denmark)

    Poletto, Marco; Pasquero, Claudia

    2012-01-01

    This is a manual investigating the subject of urban ecology and systemic development from the perspective of architectural design. It sets out to explore two main goals: to discuss the contemporary relevance of a systemic practice to architectural design, and to share a toolbox of informational...... design protocols developed to describe the city as a territory of self-organization. Collecting together nearly a decade of design experiments by the authors and their practice, ecoLogicStudio, the book discusses key disciplinary definitions such as ecologic urbanism, algorithmic architecture, bottom......-up or tactical design, behavioural space and the boundary of the natural and the artificial realms within the city and architecture. A new kind of "real-time world-city" is illustrated in the form of an operational design manual for the assemblage of proto-architectures, the incubation of proto...

  10. Humanizing Architecture

    DEFF Research Database (Denmark)

    Toft, Tanya Søndergaard

    2015-01-01

    The article proposes the urban digital gallery as an opportunity to explore the relationship between ‘human’ and ‘technology,’ through the programming of media architecture. It takes a curatorial perspective when proposing an ontological shift from considering media facades as visual spectacles to...... agency and a sense of being by way of dematerializing architecture. This is achieved by way of programming the symbolic to provide new emotional realizations and situations of enlightenment in the public audience. This reflects a greater potential to humanize the digital in media architecture....

  11. Architectural technology

    DEFF Research Database (Denmark)

    2005-01-01

    The booklet offers an overall introduction to the Institute of Architectural Technology and its projects and activities, and an invitation to the reader to contact the institute or the individual researcher for further information. The research, which takes place at the Institute of Architectural...... Technology at the Roayl Danish Academy of Fine Arts, School of Architecture, reflects a spread between strategic, goal-oriented pilot projects, commissioned by a ministry, a fund or a private company, and on the other hand projects which originate from strong personal interests and enthusiasm of individual...

  12. Architectural Mealscapes

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen; Fisker, Anna Marie; Kirkegaard, Poul Henning

    2012-01-01

    German architect Gottfried Semper developed a theory on the “four elements of Architecture” tracing the origin of architecture back to the rise of the early human settlement and the creation of fire. With the notion ‘hearth’ as the first motive in architecture and the definition of three enclosing...... motives; mounding, enclosure and roof, Semper linked the cultural and social values of the primordial fireplace with the order and shape of architecture. He claimed that any building ever made was nothing but a variation of the first primitive shelters erected around the fireplace, and that the three...... enclosing motives existed only as defenders of the “sacred flame”. In that way Semper developed the idea that any architectural scenery can be described, analyzed and explained by understanding the contextual, symbolic and social values of how the four basic motives of hearth, mounding, enclosure, and roof...

  13. Framing Architecture

    OpenAIRE

    Shirey, David E.

    2002-01-01

    The following thesis is comprised of a pair of projects focused on the making of architecture through the concept of framing. The work was conducted at the Academia dà ­Architettura in Mendrisio, Switzerland, under the direction of Peter Zumthor, Miguel Kreisler and Myriam Sterling, emphasizing the relationship between ordered structures and contextual propriety. The making of architecture is inherently most pure when approached as the subtraction of unnecessary elements and a distillation ...

  14. Textile Architecture

    OpenAIRE

    Maurin, Bernard; Motro, René

    2013-01-01

    The basic idea for a textile architecture project originates during early meetings between the architect and the engineer. The morphologic richness of such projects is provided by the varying curvatures of shapes, in contradiction with a classical straight line and orthogonal architecture. However the rules of construction are quite different in terms of realisation and of mechanical behaviour: textile membranes are subjected to a pre-stress conferring them their rigidity, and a major objecti...

  15. Fractal Architecture

    OpenAIRE

    Rumież, Agnieszka

    2013-01-01

    Research focuses on the recognition of the disposition of natural environment, which serves as an inspiration for cultural creation as it has always been in the history of architecture. Modern mathematical model of fractal geometry has been used to understand patterns occurring in the surrounding. The comparative analysis has been conducted between the abstract mathematical model and architectural composition in the view of contemporary cognitive paradigms. In conclusion, a hypothesis of a ne...

  16. IAIMS Architecture

    OpenAIRE

    Hripcsak, George

    1997-01-01

    An information system architecture defines the components of a system and the interfaces among the components. A good architecture is essential for creating an Integrated Advanced Information Management System (IAIMS) that works as an integrated whole yet is flexible enough to accommodate many users and roles, multiple applications, changing vendors, evolving user needs, and advancing technology. Modularity and layering promote flexibility by reducing the complexity of...

  17. Growth and characterization of ZnSe/CdSe/ZnSe quantum dots fabricated by using an alternate molecular beam supplying method

    International Nuclear Information System (INIS)

    ZnSe/CdSe/ZnSe structures inserted CdSe thin layer are fabricated using an alternate molecular beam supply (ALS). Examining the PL peak energy dependence on beam irradiation time in ALS cycle, we studied the initial stage of CdSe growth. When CdSe below the critical thickness is supplied on ZnSe grown on GaAs (1 0 0), two kinds of 2D islands (platelets) appear. We confirmed the alloying of 2D-CdSe islands and 3D-CdSe islands (dots) is prominent under Cd beam irradiation in ALS growth

  18. Architectural geometry

    KAUST Repository

    Pottmann, Helmut

    2014-11-26

    Around 2005 it became apparent in the geometry processing community that freeform architecture contains many problems of a geometric nature to be solved, and many opportunities for optimization which however require geometric understanding. This area of research, which has been called architectural geometry, meanwhile contains a great wealth of individual contributions which are relevant in various fields. For mathematicians, the relation to discrete differential geometry is significant, in particular the integrable system viewpoint. Besides, new application contexts have become available for quite some old-established concepts. Regarding graphics and geometry processing, architectural geometry yields interesting new questions but also new objects, e.g. replacing meshes by other combinatorial arrangements. Numerical optimization plays a major role but in itself would be powerless without geometric understanding. Summing up, architectural geometry has become a rewarding field of study. We here survey the main directions which have been pursued, we show real projects where geometric considerations have played a role, and we outline open problems which we think are significant for the future development of both theory and practice of architectural geometry.

  19. Recycling industrial architecture : the redefinition of the recycling principles in the context of sustainable architectural design

    OpenAIRE

    Šijaković, Milan

    2015-01-01

    The aim of this thesis is the elucidation of the concept of architectural recycling as an environmentally sustainable alternative to demolition and preservation. More precisely, the research aim relates to the redefinition of recycling design principles in the context of the sustainable architectural design. The process of architectural recycling was placed in the context of a sustainable architectural design, as the global concept of sustainable development is imposed as a general context fo...

  20. IAIMS architecture.

    Science.gov (United States)

    Hripcsak, G

    1997-01-01

    An information system architecture defines the components of a system and the interfaces among the components. A good architecture is essential for creating an Integrated Advanced Information Management System (IAIMS) that works as an integrated whole yet is flexible enough to accommodate many users and roles, multiple applications, changing vendors, evolving user needs, and advancing technology. Modularity and layering promote flexibility by reducing the complexity of a system and by restricting the ways in which components may interact. Enterprise-wide mediation promotes integration by providing message routing, support for standards, dictionary-based code translation, a centralized conceptual data schema, business rule implementation, and consistent access to databases. Several IAIMS sites have adopted a client-server architecture, and some have adopted a three-tiered approach, separating user interface functions, application logic, and repositories. PMID:9067884

  1. Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    Architecture and anthropology have always had a common focus on dwelling, housing, urban life and spatial organisation. Current developments in both disciplines make it even more relevant to explore their boundaries and overlaps. Architects are inspired by anthropological insights and methods......, while recent material and spatial turns in anthropology have also brought an increasing interest in design, architecture and the built environment. Understanding the relationship between the social and the physical is at the heart of both disciplines, and they can obviously benefit from further...... collaboration: How can qualitative anthropological approaches contribute to contemporary architecture? And just as importantly: What can anthropologists learn from architects’ understanding of spatial and material surroundings? Recent theoretical developments in anthropology stress the role of materials and...

  2. Architectural Narratives

    DEFF Research Database (Denmark)

    Kiib, Hans

    2010-01-01

    In this essay, I focus on the combination of programs and the architecture of cultural projects that have emerged within the last few years. These projects are characterized as “hybrid cultural projects,” because they intend to combine experience with entertainment, play, and learning. This essay...... identifies new rationales related to this development, and it argues that “cultural planning” has increasingly shifted its focus from a cultural institutional approach to a more market-oriented strategy that integrates art and business. The role of architecture has changed, too. It not only provides a...... functional framework for these concepts, but tries increasingly to endow the main idea of the cultural project with a spatially aesthetic expression - a shift towards “experience architecture.” A great number of these projects typically recycle and reinterpret narratives related to historical buildings and...

  3. Architectural Engineers

    DEFF Research Database (Denmark)

    Petersen, Rikke Premer

    engineering is addresses from two perspectives – as an educational response and an occupational constellation. Architecture and engineering are two of the traditional design professions and they frequently meet in the occupational setting, but at educational institutions they remain largely estranged. The...... paper builds on a multi-sited study of an architectural engineering program at the Technical University of Denmark and an architectural engineering team within an international engineering consultancy based on Denmark. They are both responding to new tendencies within the building industry where the...... role of engineers and architects increasingly overlap during the design process, but their approaches reflect different perceptions of the consequences. The paper discusses some of the challenges that design education, not only within engineering, is facing today: young designers must be equipped with...

  4. Architectural Theatricality

    DEFF Research Database (Denmark)

    Tvedebrink, Tenna Doktor Olsen

    initiatives in Aalborg Hospital to overcome patient undernutrition by refurbishing eating environments, this thesis engages in an investigation of the interior architectural qualities of patient eating environments. The relevance for this holistic perspective, synthesizing health, food and architecture...... environments and a knowledge gap therefore exists in present hospital designs. Consequently, the purpose of this thesis has been to investigate if any research-based knowledge exist supporting the hypothesis that the interior architectural qualities of eating environments influence patient food intake, health...... such as a literature review, timeline and historical outline to create a “knowledge map”, which in an eclectic manner merges the positive, normative and polemical knowledge rooted in research, objects and writings. The results of these investigations show that sparse researchbased knowledge exist directly taking...

  5. Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    and other spaces that architects are preoccupied with. On the other hand, the distinction between architecture and design is not merely one of scale. Design and architecture represent – at least in Denmark – also quite different disciplinary traditions and methods. Where designers develop prototypes......, architects tend to work with models and plans that are not easily understood by lay people. Further, many architects are themselves sceptical towards notions of user-involvement and collaborative design. They fear that the imagination of citizens and users is restricted to what they are already familiar with...

  6. Reframing Architecture

    DEFF Research Database (Denmark)

    Riis, Søren

    2013-01-01

    I would like to thank Prof. Stephen Read (2011) and Prof. Andrew Benjamin (2011) for both giving inspiring and elaborate comments on my article “Dwelling in-between walls: the architectural surround”. As I will try to demonstrate below, their two different responses not only supplement my article...... focuses on how the absence of an initial distinction might threaten the endeavour of my paper. In my reply to Read and Benjamin, I will discuss their suggestions and arguments, while at the same time hopefully clarifying the postphenomenological approach to architecture....

  7. Multithreading architecture

    CERN Document Server

    Nemirovsky, Mario

    2013-01-01

    Multithreaded architectures now appear across the entire range of computing devices, from the highest-performing general purpose devices to low-end embedded processors. Multithreading enables a processor core to more effectively utilize its computational resources, as a stall in one thread need not cause execution resources to be idle. This enables the computer architect to maximize performance within area constraints, power constraints, or energy constraints. However, the architectural options for the processor designer or architect looking to implement multithreading are quite extensive and

  8. Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors

    OpenAIRE

    Peacock, Jacqueline D; Cherba, David; Kampfschulte, Kevin; Smith, Mallory K; Monks, Noel R; Webb, Craig P.; Steensma, Matthew

    2013-01-01

    Background Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A overexpression in these tumors, doxorubicin resistance is common, and the mechanisms of chemotherapy resistance in MPNST are poorly understood. Molecular-guided therapy prediction is an emerging strategy for treatment refractory sarcomas that involves identification of therap...

  9. From green architecture to architectural green

    DEFF Research Database (Denmark)

    Earon, Ofri

    2011-01-01

    The paper investigates the topic of green architecture from an architectural point of view and not an energy point of view. The purpose of the paper is to establish a debate about the architectural language and spatial characteristics of green architecture. In this light, green becomes an adjective...... that describes the architectural exclusivity of this particular architecture genre. The adjective green expresses architectural qualities differentiating green architecture from none-green architecture. Currently, adding trees and vegetation to the building’s facade is the main architectural characteristics...... of green architecture. The paper argues that this greenification of facades is insufficient. The green is only a skin cladding the exterior envelope without having a spatial significance. Through the paper it is proposed to flip the order of words from green architecture to architectural green...

  10. Religious Architecture

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The main religions of ancient China were Buddhism,Taoism and Islam, of which Buddhism was the most widespread. As a result, Buddhist temples and towers are found all over China, and have become important components of the country's ancient architecture.

  11. HRST architecture modeling and assessments

    Science.gov (United States)

    Comstock, Douglas A.

    1997-01-01

    This paper presents work supporting the assessment of advanced concept options for the Highly Reusable Space Transportation (HRST) study. It describes the development of computer models as the basis for creating an integrated capability to evaluate the economic feasibility and sustainability of a variety of system architectures. It summarizes modeling capabilities for use on the HRST study to perform sensitivity analysis of alternative architectures (consisting of different combinations of highly reusable vehicles, launch assist systems, and alternative operations and support concepts) in terms of cost, schedule, performance, and demand. In addition, the identification and preliminary assessment of alternative market segments for HRST applications, such as space manufacturing, space tourism, etc., is described. Finally, the development of an initial prototype model that can begin to be used for modeling alternative HRST concepts at the system level is presented.

  12. Alternative Architecture for Commercial Space Solar Power

    Science.gov (United States)

    Potter, Seth

    2000-01-01

    This presentation discuss the space solar power (SSP) concept. It takes us step by step through the process: the use of sunlight and solar cells to create power, the conversion of the sunlight into electricity, the conversion of electricity to microwaves, and finally the from microwaves back to electricity by the Rectennas on Earth.

  13. On Control Strategies for Responsive Architectural Structures

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Parigi, Dario

    2012-01-01

    The present paper considers control of responsive architectural structures for improvement of structural performance by recognizing changes in their environments and loads, adapting to meet goals, and using past events to improve future performance or maintain serviceability. The general scope of...... the paper is to discuss control strategies for responsive architectural structures, particularly reconfigurable architectural structures which can transform body shape, i.e. a transformation into more than one or two different shape alternatives....

  14. From internet architecture research to standards

    OpenAIRE

    Papadimitriou D.; Sales B.; Demeester P.; Zahariadis T.

    2012-01-01

    Many Internet architectural research initiatives have been undertaken over last twenty years. None of them actually reached their intended goal: the evolution of the Internet architecture is still driven by its protocols not by genuine architectural evolutions. As this approach becomes the main limiting factor of Internet growth and application deployment, this paper proposes an alternative research path starting from the root causes (the progressive depletion of the design principles of the ...

  15. Morphology, molecular data, and development of Zschokkella mugilis (Myxosporea, Bivalvulida) in a polychaete alternate host, Nereis diversicolor.

    Science.gov (United States)

    Rangel, Luís F; Santos, Maria J; Cech, Gábor; Székely, Csaba

    2009-06-01

    The morphology of Zschokkella mugilis Sitjà-Bobadilla and Alvarez-Pellitero, 1993 (Myxosporea, Bivalvulida) in Nereis diversicolor O. F. Müller, 1776 is described for the first time. The molecular data show that the actinospore has 100% similarity to the myxospore of Z. mugilis. Fully mature actinospores are tri-radiate, the spore body has a small process, and the sporoplasm has 2 inner daughter cells. In the polychaete, the spores of the parasite develop in groups of 8 inside pansporocysts. The schizogony phase takes place in the intestinal epithelium, while gametogony and sporogony occur in the coelom of the polychaete. Observations indicate that mature spores are released only during the polychaete reproductive season. Infection was detected only in the winter and spring. In the Aveiro estuary (Portugal), the overall prevalence of infection of the polychaete was 0.5%. PMID:18939897

  16. Alternative CHCA-based matrices for the analysis of low molecular weight compounds by UV-MALDI-tandem mass spectrometry.

    Science.gov (United States)

    Porta, Tiffany; Grivet, Chantal; Knochenmuss, Richard; Varesio, Emmanuel; Hopfgartner, Gérard

    2011-02-01

    Analysis of low molecular weight compounds (LMWC) in complex matrices by vacuum matrix-assisted laser desorption/ionization (MALDI) often suffers from matrix interferences, which can severely degrade limits of quantitation. It is, therefore, useful to have available a range of suitable matrices, which exhibit complementary regions of interference. Two newly synthesized α-cyanocinnamic acid derivatives are reported here; (E)-2-cyano-3-(naphthalen-2-yl)acrylic acid (NpCCA) and (2E)-3-(anthracen-9-yl)-2-cyanoprop-2enoic acid (AnCCA). Along with the commonly used α-cyano-4-hydroxycinnamic acid (CHCA), and the recently developed 4-chloro-α-cyanocinnamic acid (Cl-CCA) matrices, these constitute a chemically similar series of matrices covering a range of molecular weights, and with correspondingly differing ranges of spectral interference. Their performance was compared by measuring the signal-to-noise ratios (S/N) of 47 analytes, mostly pharmaceuticals, with the different matrices using the selected reaction monitoring (SRM) mode on a triple quadrupole instrument equipped with a vacuum MALDI source. AnCCA, NpCCA and Cl-CCA were found to offer better signal-to-noise ratios in SRM mode than CHCA, but Cl-CCA yielded the best results for 60% of the compounds tested. To better understand the relative performance of this matrix series, the proton affinities (PAs) were measured using the kinetic method. Their relative values were: AnCCA > CHCA > NpCCA > Cl-CCA. This ordering is consistent with the performance data. The synthesis of the new matrices is straightforward and they provide (1) tunability of matrix background interfering ions and (2) enhanced analyte response for certain classes of compounds. PMID:21259393

  17. Kosmos = architecture

    Directory of Open Access Journals (Sweden)

    Tine Kurent

    2015-10-01

    Full Text Available The old Greek word "kosmos" means not only "cosmos", but also "the beautiful order", "the way of building", "building", "scenography", "mankind", and, in the time of the New Testament, also "pagans". The word "arhitekton", meaning first the "master of theatrical scenography", acquired the meaning of "builder", when the words "kosmos" and ~kosmetes" became pejorative. The fear that architecture was not considered one of the arts before Renaissance, since none of the Muses supervised the art of building, results from the misunderstanding of the word "kosmos". Urania was the Goddes of the activity implied in the verb "kosmein", meaning "to put in the beautiful order" - everything, from the universe to the man-made space, i. e. the architecture.

  18. MUF architecture /art London

    DEFF Research Database (Denmark)

    Svenningsen Kajita, Heidi

    2009-01-01

    Om MUF architecture samt interview med Liza Fior og Katherine Clarke, partnere i muf architecture/art......Om MUF architecture samt interview med Liza Fior og Katherine Clarke, partnere i muf architecture/art...

  19. Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal

    Directory of Open Access Journals (Sweden)

    Dmitri Papatsenko

    2015-08-01

    Full Text Available Analyses of gene expression in single mouse embryonic stem cells (mESCs cultured in serum and LIF revealed the presence of two distinct cell subpopulations with individual gene expression signatures. Comparisons with published data revealed that cells in the first subpopulation are phenotypically similar to cells isolated from the inner cell mass (ICM. In contrast, cells in the second subpopulation appear to be more mature. Pluripotency Gene Regulatory Network (PGRN reconstruction based on single-cell data and published data suggested antagonistic roles for Oct4 and Nanog in the maintenance of pluripotency states. Integrated analyses of published genomic binding (ChIP data strongly supported this observation. Certain target genes alternatively regulated by OCT4 and NANOG, such as Sall4 and Zscan10, feed back into the top hierarchical regulator Oct4. Analyses of such incoherent feedforward loops with feedback (iFFL-FB suggest a dynamic model for the maintenance of mESC pluripotency and self-renewal.

  20. Fragment-based (13)C nuclear magnetic resonance chemical shift predictions in molecular crystals: An alternative to planewave methods.

    Science.gov (United States)

    Hartman, Joshua D; Monaco, Stephen; Schatschneider, Bohdan; Beran, Gregory J O

    2015-09-14

    We assess the quality of fragment-based ab initio isotropic (13)C chemical shift predictions for a collection of 25 molecular crystals with eight different density functionals. We explore the relative performance of cluster, two-body fragment, combined cluster/fragment, and the planewave gauge-including projector augmented wave (GIPAW) models relative to experiment. When electrostatic embedding is employed to capture many-body polarization effects, the simple and computationally inexpensive two-body fragment model predicts both isotropic (13)C chemical shifts and the chemical shielding tensors as well as both cluster models and the GIPAW approach. Unlike the GIPAW approach, hybrid density functionals can be used readily in a fragment model, and all four hybrid functionals tested here (PBE0, B3LYP, B3PW91, and B97-2) predict chemical shifts in noticeably better agreement with experiment than the four generalized gradient approximation (GGA) functionals considered (PBE, OPBE, BLYP, and BP86). A set of recommended linear regression parameters for mapping between calculated chemical shieldings and observed chemical shifts are provided based on these benchmark calculations. Statistical cross-validation procedures are used to demonstrate the robustness of these fits. PMID:26374002

  1. Fragment-based 13C nuclear magnetic resonance chemical shift predictions in molecular crystals: An alternative to planewave methods

    International Nuclear Information System (INIS)

    We assess the quality of fragment-based ab initio isotropic 13C chemical shift predictions for a collection of 25 molecular crystals with eight different density functionals. We explore the relative performance of cluster, two-body fragment, combined cluster/fragment, and the planewave gauge-including projector augmented wave (GIPAW) models relative to experiment. When electrostatic embedding is employed to capture many-body polarization effects, the simple and computationally inexpensive two-body fragment model predicts both isotropic 13C chemical shifts and the chemical shielding tensors as well as both cluster models and the GIPAW approach. Unlike the GIPAW approach, hybrid density functionals can be used readily in a fragment model, and all four hybrid functionals tested here (PBE0, B3LYP, B3PW91, and B97-2) predict chemical shifts in noticeably better agreement with experiment than the four generalized gradient approximation (GGA) functionals considered (PBE, OPBE, BLYP, and BP86). A set of recommended linear regression parameters for mapping between calculated chemical shieldings and observed chemical shifts are provided based on these benchmark calculations. Statistical cross-validation procedures are used to demonstrate the robustness of these fits

  2. Haptic architecture becomes architectural hap

    OpenAIRE

    Herssens, Jasmien; Heylighen, Ann

    2007-01-01

    Universal Design is a recent design paradigm which aims at handicap elimination in the physical environment and strives for a more humanized architecture. After pointing out the value of Universal Design, the paper advances human centred design as a possible methodology to make this paradigm operational. Key to this methodology is the explicit attention for cognitive human factors in experiencing space and—the focus of this paper—for the role played by the sense of tou...

  3. Molecular characterization, alternative splicing and expression analysis of ACSF2 and its correlation with egg-laying performance in geese.

    Science.gov (United States)

    Yu, S; Wei, W; Xia, M; Jiang, Z; He, D; Li, Z; Han, H; Chu, W; Liu, H; Chen, J

    2016-08-01

    ACSF2 (encoded by acyl-CoA synthetase family member 2) belongs to the acyl-CoA synthetase (ACS) family, activating fatty acids by forming a thioester bond with CoA. In our previous study, a SNP residing in the intron of ACSF2 was identified to be linked to goose egg-laying performance. But the structure of goose ACSF2 as well as its role in reproduction remains unknown. In this study, we cloned and characterized ACSF2 in Yangzhou geese. A total of four alternative splice variants, designated as ACSF2-1, ACSF2-2, ACSF2-3 and ACSF2-4 respectively, were identified in the ovary. The coding regions of the four variants are 1770, 1692, 1599 and 1917 bp in length, respectively encoding 589, 563, 532 and 638 amino acids with conserved AMP-binding sites. All ACSF2 variants were widely expressed in 11 tested tissues in geese, except that the ACSF2-2 transcript was not detected in hypothalamus, pituitary gland and granulosa cells. Subcellular localization revealed that ACSF2 is a mitochondrial matrix protein. ACSF2 mRNA level was compared between high egg production (HEP; n = 8) and low egg production (LEP; n = 10) groups and showed a lower (P < 0.05) mRNA level in the HEP group. Further experiments indicated that overexpressing ACSF2 resulted in a significant increase of caspase-3 mRNA levels and that ACSF2 knockdown triggered a decrease in the caspase-3 mRNA level in granulosa cells. Similarly, the lower caspase-3 mRNA levels were identified in ovaries of the HEP group with lower ACSF2 mRNA levels. The research showed that the ACSF2 mRNA levels had a positive correlation with caspase-3 mRNA levels in vivo (R = 0.86, P < 0.01). Our results suggest that lower ACSF2 expression promotes the laying performance of goose possibly by inhibiting granulosa cell apoptosis and facilitating follicular development. PMID:27062512

  4. Textile Architecture

    DEFF Research Database (Denmark)

    Heimdal, Elisabeth Jacobsen

    2010-01-01

    Textiles can be used as building skins, adding new aesthetic and functional qualities to architecture. Just like we as humans can put on a coat, buildings can also get dressed. Depending on our mood, or on the weather, we can change coat, and so can the building. But the idea of using textiles...... to create human habitation is not new. As Diether S. Hope phrases it, referring to tents: The history of development of humanity would be barely conceivable without free spanning textile membrane structures....

  5. FPGA Based Intelligent Co-operative Processor in Memory Architecture

    DEFF Research Database (Denmark)

    Ahmed, Zaki; Sotudeh, Reza; Hussain, Dil Muhammad Akbar;

    2011-01-01

    In a continuing effort to improve computer system performance, Processor-In-Memory (PIM) architecture has emerged as an alternative solution. PIM architecture incorporates computational units and control logic directly on the memory to provide immediate access to the data. To exploit the potentia...... methods to ensure a speedup assessment obtained against base-line architecture....

  6. A bio-inspired design strategy: Organization of tryptophan-appended naphthalenediimide into well-defined architectures induced by molecular interactions

    Science.gov (United States)

    Avinash, M. B.; Govindaraju, T.

    2011-06-01

    The chemistry of molecular assemblies involves weak yet complex non-covalent interactions, and the molecular organization of the π-conjugated material is crucial in determining the performance of an organic electronic device. Herein we demonstrate a bioinspired design strategy to tune the self-assembly of naphthalenediimides (NDIs) by minute structural variations, π-π stacking, hydrophobic interactions and metal interactions. We address some of the limitations associated with current design strategies, such as restriction to a specific molecular interaction or the difficulty in controlling the assembly due to several complicated intermolecular interactions. Hydrophobic-effect-induced J-type aggregation and sodium-interaction-induced H-type aggregation of tryptophan-appended NDIs have been illustrated. 1H NMR spectra further reveal sodium cation-π interactions in tryptophan-appended NDIs, while NMR and IR spectroscopic studies confirm the structural variations associated with the molecular assembly. In summary, the molecular organization has been successfully transformed from nanospheres to particles, nanobelts, fibers and fractals. Such drastic changes in the morphology are clear and striking evidence of the importance of non-trivial weak non-covalent forces.The chemistry of molecular assemblies involves weak yet complex non-covalent interactions, and the molecular organization of the π-conjugated material is crucial in determining the performance of an organic electronic device. Herein we demonstrate a bioinspired design strategy to tune the self-assembly of naphthalenediimides (NDIs) by minute structural variations, π-π stacking, hydrophobic interactions and metal interactions. We address some of the limitations associated with current design strategies, such as restriction to a specific molecular interaction or the difficulty in controlling the assembly due to several complicated intermolecular interactions. Hydrophobic-effect-induced J-type aggregation

  7. Supramolecular architectures

    Directory of Open Access Journals (Sweden)

    Franco Cacialli

    2004-04-01

    Full Text Available The ability to manipulate the local molecular environment is crucial to access fundamentally new classes of organic functional materials with unprecedented properties and performance. Despite the progress of the last ten years in the area of organic semiconductors for electronics and optoelectronics, much remains to be done to achieve control at the nanoscale of the local environment of the functional molecules, both regarding interaction with other molecular units or species and with the electrodes or other inorganic components of the ‘device’.

  8. Decoding the architectural theory

    Institute of Scientific and Technical Information of China (English)

    Gu Mengchao

    2008-01-01

    Starting from the illustration of the definition and concept of the architectural theory, the author established his unique understanding about the framework of the architectural theory and the innovation of the architectural theory underlined by Chinese characteristics.

  9. Preserving Architectural Decisions through Architectural Patterns

    OpenAIRE

    Thon That, Minh Tu; Sadou, Salah; Oquendo, F.; Fleurquin, R

    2014-01-01

    International audience Architectural decisions have emerged as a means to maintain the quality of the architecture during its evolution. One of the most important de-cisions made by architects are those about the design approach such as the use of patterns or styles in the architecture. The structural nature of this type of decisions give them the potential to be controlled systematically. In the litera-ture, there are some works on the automation of architectural decision violation checki...

  10. Architectures of prototypes and architectural prototyping

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Christensen, Michael; Sandvad, Elmer;

    1998-01-01

    sessions with users, - evolve over a long period of time to contain more functionality - allow for 6-7 developers working intensively in parallel. Explicit focus on the software architecture and letting the architecture evolve with the prototype played a major role in resolving these conflicting...... constraints. Specifically allowing explicit restructuring phases when the architecture became problematic showed to be crucial.  ...

  11. Software architecture 2

    CERN Document Server

    Oussalah, Mourad Chabanne

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural templa

  12. Lightweight enterprise architectures

    CERN Document Server

    Theuerkorn, Fenix

    2004-01-01

    STATE OF ARCHITECTUREArchitectural ChaosRelation of Technology and Architecture The Many Faces of Architecture The Scope of Enterprise Architecture The Need for Enterprise ArchitectureThe History of Architecture The Current Environment Standardization Barriers The Need for Lightweight Architecture in the EnterpriseThe Cost of TechnologyThe Benefits of Enterprise Architecture The Domains of Architecture The Gap between Business and ITWhere Does LEA Fit? LEA's FrameworkFrameworks, Methodologies, and Approaches The Framework of LEATypes of Methodologies Types of ApproachesActual System Environmen

  13. Software architecture 1

    CERN Document Server

    Oussalah , Mourad Chabane

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural template

  14. Self assembly of interlocked architectures

    CERN Document Server

    Schergna, S

    2002-01-01

    An area of great interest is the synthesis and characterisation of molecules possessing moving parts, with the goal that they can act as 'molecular machine' carrying out tasks that molecules with fixed conventional architectures cannot do. Rotaxanes and catenanes (mechanically interlocked architectures) represent one approach toward achieving these aims as their component wheels and / or threads are connected together but can still move, in certain, controlled directions. This thesis focused on the study of structural rigidity and the preorganisation of thread binding sites as factors of major influence on template efficiency in the synthesis of hydrogen bond assembled supramolecular structures (rotaxanes and catenanes). Chapter One gives a brief outline of the common synthetic approaches to interlocked architectures (catenanes and rotaxanes) that are now being developed to address the problems outlined above. Chapter Two and Chapter Three concerns the synthesis of novel amide-based rotaxanes containing vario...

  15. Molecular Nanoelectronics

    OpenAIRE

    Vuillaume, Dominique

    2010-01-01

    Molecular electronics is envisioned as a promising candidate for the nanoelectronics of the future. More than a possible answer to ultimate miniaturization problem in nanoelectronics, molecular electronics is foreseen as a possible way to assemble a large numbers of nanoscale objects (molecules, nanoparticules, nanotubes and nanowires) to form new devices and circuit architectures. It is also an interesting approach to significantly reduce the fabrication costs, as well as the energetical cos...

  16. Effect of Molecular Architecture of PDMAEMA-POEGMA Random and Block Copolymers on Their Adsorption on Regenerated and Anionic Nanocelluloses and Evidence of Interfacial Water Expulsion.

    Science.gov (United States)

    Vuoriluoto, Maija; Orelma, Hannes; Johansson, Leena-Sisko; Zhu, Baolei; Poutanen, Mikko; Walther, Andreas; Laine, Janne; Rojas, Orlando J

    2015-12-10

    Block copolymers of poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) with varying block sizes were synthesized by consecutive reversible addition-fragmentation chain transfer (RAFT) polymerization and then exposed to cellulose substrates with different anionic charge density. The extent and dynamics of quaternized PDMAEMA-b-POEGMA adsorption on regenerated cellulose, cellulose nanofibrils (CNF), and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)-oxidized cellulose nanofibrils (TOCNF) was determined by using electromechanical and optical techniques, namely, quartz crystal microbalance (QCM-D) and surface plasmon resonance (SPR), respectively. PDMAEMA-b-POEGMA equilibrium adsorption increased with the anionic charge of cellulose, an indication of electrostatic interactions. Such an observation was further confirmed by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). Depending on their architecture, adsorption on TOCNF of some of the PDMAEMA-b-POEGMA copolymers produced a significant reduction in QCM frequency, as expected from large mass uptake, while surprisingly, other copolymers induced the opposite effect. This latter, remarkable behavior was ascribed to coupled water expulsion from the interface upon charge neutralization of anionic surface sites with adsorbing cationic polymer segments. These observations were further investigated with SPR and QCM-D measurements using deuterium oxide solvent exchange to determine the amount of coupled water at the TOCNF-block copolymer interface. Finally, random copolymers with similar composition adsorbed to a larger extent compared to the respective block copolymers, revealing the effect of adsorbed loops and tails as well as hydration. PMID:26560798

  17. Structural modeling of HLA-B*1502/peptide/carbamazepine/T-cell receptor complex architecture: implication for the molecular mechanism of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

    Science.gov (United States)

    Zhou, Peng; Zhang, Shilei; Wang, Yewang; Yang, Chao; Huang, Jian

    2016-08-01

    Drug-induced adverse reactions are a significant problem in healthcare worldwide and are estimated to cost billions of dollars annually in the United States. A portion of such reactions is observed to strongly associate with certain human leukocyte antigen (HLA) alleles; one of the strongest associations is the HLA-B*1502 protein with carbamazepine (CBZ)-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) - the odds ratio value can even be higher than one thousand. The particularly strong association in CBZ-induced SJS/TEN suggests that the HLA-B*1502 is not only a genetic marker but also a participant in the pathogenesis of the disease. In the current study, we attempt to computationally model the atomic-level structure of the complete HLA-B*1502/peptide/CBZ/T-cell receptor (TCR) complex architecture based on prior knowledge obtained from epidemiological investigations as well as in vitro and in vivo assays. The model tells a different story about the molecular mechanism of CBZ-induced SJS/TEN from that previously reported for abacavir (ABC)-induced hypersensitivity (HSR); the CBZ molecule is located at the interface between HLA-B*1502/peptide and TCR, directly contacts the P3-P6 residues of antigen peptide, and bound within a pocket region encompassed by two TCR CDR3 fingers. Molecular dynamics simulation and binding energy analysis further reveal that the CBZ shows considerably high affinity to TCR over HLA-B*1502/peptide, which can tightly interact with the former rather than the latter. From the model, two hypotheses are proposed that can well explain most previous observations and are expected to guide next wet-lab experiments. This study could help to promote our understanding of the molecular mechanism and pathological implication underlying CBZ-induced SJS/TEN. PMID:26488421

  18. Effects of p-(Trifluoromethoxy)benzyl and p-(Trifluoromethoxy)phenyl Molecular Architecture on the Performance of Naphthalene Tetracarboxylic Diimide-Based Air-Stable n-Type Semiconductors.

    Science.gov (United States)

    Zhang, Dongwei; Zhao, Liang; Zhu, Yanan; Li, Aiyuan; He, Chao; Yu, Hongtao; He, Yaowu; Yan, Chaoyi; Goto, Osamu; Meng, Hong

    2016-07-20

    N,N'-Bis(4-trifluoromethoxyphenyl) naphthalene-1,4,5,8-tetracarboxylic acid diimide (NDI-POCF3) and N,N'-bis(4-trifluoromethoxybenzyl) naphthalene-1,4,5,8-tetracarboxylic acid diimide (NDI-BOCF3) have similar optical and electrochemical properties with a deep LUMO level of approximately 4.2 eV, but exhibit significant differences in electron mobility and molecular packing. NDI-POCF3 exhibits nondetectable charge mobility. Interestingly, NDI-BOCF3 shows air-stable electron transfer performance with enhanced mobility by increasing the deposition temperature onto the octadecyltrichlorosilane (OTS)-modified SiO2/Si substrates and achieves electron mobility as high as 0.7 cm(2) V(-1) s(-1) in air. The different mobilities of those two materials can be explained by several factors including thin-film morphology and crystallinity. In contrast to the poor thin-film morphology and crystallinity of NDI-POCF3, NDI-BOCF3 exhibits larger grain sizes and improved crystallinities due to the higher deposition temperature. In addition, the theoretical calculated transfer integrals of the intermolecular lowest unoccupied molecular orbital (LUMO) of the two materials further show that a large intermolecular orbital overlap of NDI-BOCF3 can transfer electron more efficiently than NDI-POCF3 in thin-film transistors. On the basis of fact that the theoretical calculations are consistent with the experimental results, it can be concluded that the p-(trifluoromethoxy) benzyl (BOCF3) molecular architecture on the former position of the naphthalene tetracarboxylic diimides (NDI) core provides a more effective way to enhance the intermolecular electron transfer property than the p-(trifluoromethoxy) phenyl (POCF3) group for the future design of NDI-related air-stable n-channel semiconductor. PMID:27355858

  19. Alternative security

    International Nuclear Information System (INIS)

    This book contains the following chapters: The Military and Alternative Security: New Missions for Stable Conventional Security; Technology and Alternative Security: A Cherished Myth Expires; Law and Alternative Security: Toward a Just World Peace; Politics and Alternative Security: Toward a More Democratic, Therefore More Peaceful, World; Economics and Alternative Security: Toward a Peacekeeping International Economy; Psychology and Alternative Security: Needs, Perceptions, and Misperceptions; Religion and Alternative Security: A Prophetic Vision; and Toward Post-Nuclear Global Security: An Overview

  20. Naval architecture environment : facilitating JV2010

    OpenAIRE

    Augustine, Thomas H.

    1999-01-01

    This thesis demonstrates that the C4ISR Framework Version 2.0 requirements can be satisfied with one modern object oriented CASE tool. It provides an alternative scenario centric approach to architecture development. The combination of scenarios and Unified Modeling Language (UML) semantics is referred to as the Naval Architecture Environment (NAE). Specifically, it recommended the acquisition of Rational Rose. The NAE combines the best practices of software development with the domain specif...

  1. An empirical investigation of architectural prototyping

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2010-01-01

    Architectural prototyping is the process of using executable code to investigate stakeholders’ software architecture concerns with respect to a system under development. Previous work has established this as a useful and cost-effective way of exploration and learning of the design space of a system...... prototyping in practice. First, we report findings from an ethnographic study of practicing software architects. Secondly, we report from a focus group on architectural prototyping involving architects from four companies. And, thirdly, we report from a survey study of 20 practicing software architects and...... software developers. Our findings indicate that architectural prototyping plays an important and frequent role in resolving problems experimentally, but less so in exploring alternative solutions. Furthermore, architectural prototypes include end-user or business related functionality rather than purely...

  2. The Value of Style in Architectural Practice

    DEFF Research Database (Denmark)

    Kornberger, Martin; Kreiner, Kristian; Clegg, Stewart

    2011-01-01

    To date, organization theory’s attempts to understand architecture firms have focused by and large on debates about increasing managerialization and economization of the profession. This paper suggests an alternative approach by conceptualizing architecture as practice that does not adhere only to...... a narrow economic logic of value creation but also focuses on the production of aesthetic value. We will introduce the concept of style to understand how architecture practice routinely breaks routines and follows the rule of rule breaking. We will analyze architecture practice as a form of...... organized heresy – a hegemonic engine for the production of difference. In order to illustrate our points we will draw on qualitative empirical fieldwork with an architecture firm....

  3. Creating product line architectures

    OpenAIRE

    Bayer, J.; Flege, O.; Gacek, C.

    2000-01-01

    The creation and validation of product line software architectures are inherently more complex than those of software architectures for single systems. This paper compares a process for creating and evaluating a traditional, one-of-a- kind software architecture with one for a reference software architecture. The comparison is done in the context of PuLSE-DSSA, a customizable process that integrates both product line architecture creation and evaluation.

  4. ESA: Enterprise Service Architecture

    OpenAIRE

    2010-01-01

    The Service oriented perspective is emerging as an important view both for business architecture and IT architecture in the overall context of enterprise architectures. Many existing enterprise architecture frameworks like DODAF, MODAF and NAF have lately been extended with service-oriented views. The UPDM UML Profile and Metamodel for DODAF and MODAF has thus included various service-oriented views. This thesis proposes a new enterprise architecture framework ESA Enterprise Service Arch...

  5. EAP high-level product architecture

    DEFF Research Database (Denmark)

    Guðlaugsson, Tómas Vignir; Mortensen, Niels Henrik; Sarban, Rahimullah

    2013-01-01

    EAP technology products while keeping complexity under control. High level product architecture has been developed for the mechanical part of EAP transducers, as the foundation for platform development. A generic description of an EAP transducer forms the core of the high level product architecture...... organ allow the function of the EAP transducers to be changed, by basing the EAP transducers on a different combination of organ alternatives. A model providing an overview of the high level product architecture has been developed to support daily development and cooperation across development teams...

  6. Alternative Splice in Alternative Lice.

    Science.gov (United States)

    Tovar-Corona, Jaime M; Castillo-Morales, Atahualpa; Chen, Lu; Olds, Brett P; Clark, John M; Reynolds, Stuart E; Pittendrigh, Barry R; Feil, Edward J; Urrutia, Araxi O

    2015-10-01

    Genomic and transcriptomics analyses have revealed human head and body lice to be almost genetically identical; although con-specific, they nevertheless occupy distinct ecological niches and have differing feeding patterns. Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases; epidemictyphus, trench fever, and relapsing fever. In order to gain insights into the molecular bases for these differences, we analyzed alternative splicing (AS) using next-generation sequencing data for one strain of head lice and one strain of body lice. We identified a total of 3,598 AS events which were head or body lice specific. Exon skipping AS events were overrepresented among both head and body lice, whereas intron retention events were underrepresented in both. However, both the enrichment of exon skipping and the underrepresentation of intron retention are significantly stronger in body lice compared with head lice. Genes containing body louse-specific AS events were found to be significantly enriched for functions associated with development of the nervous system, salivary gland, trachea, and ovarian follicle cells, as well as regulation of transcription. In contrast, no functional categories were overrepresented among genes with head louse-specific AS events. Together, our results constitute the first evidence for transcript pool differences in head and body lice, providing insights into molecular adaptations that enabled human lice to adapt to clothing, and representing a powerful illustration of the pivotal role AS can play in functional adaptation. PMID:26169943

  7. Engineering molecular machines

    Science.gov (United States)

    Erman, Burak

    2016-04-01

    Biological molecular motors use chemical energy, mostly in the form of ATP hydrolysis, and convert it to mechanical energy. Correlated thermal fluctuations are essential for the function of a molecular machine and it is the hydrolysis of ATP that modifies the correlated fluctuations of the system. Correlations are consequences of the molecular architecture of the protein. The idea that synthetic molecular machines may be constructed by designing the proper molecular architecture is challenging. In their paper, Sarkar et al (2016 New J. Phys. 18 043006) propose a synthetic molecular motor based on the coarse grained elastic network model of proteins and show by numerical simulations that motor function is realized, ranging from deterministic to thermal, depending on temperature. This work opens up a new range of possibilities of molecular architecture based engine design.

  8. Synthesis, molecular and crystalline architectures, and properties of a mononuclear complex [CoII (benzidine)2(NCS)2(OH2)2

    Indian Academy of Sciences (India)

    Subhasish Kundu; Subhasis Roy; Kishalay Bhar; Rajarshi Ghosh; Chia-Her Lin; Joan Ribas; Barindra Kumar Ghosh

    2013-07-01

    One mononuclear cobalt(II) compound of the type [Co(bnzd)2(NCS)2(OH2)2] (1) (bnzd = benzidine) has been isolated through a single-pot reaction of the molecular building components in MeOH-H2O solvent mixture at room temperature and characterized by physico-chemical and spectroscopic methods. The crystal structure of complex 1 has an octahedral geometry with trans, trans, trans orientations in the order (Na,Na), (Nt,Nt), (Ow,Ow) [Na = N(amine), Nt = N(thiocyanate) and Ow = O(water)]. In crystalline state, individual units of 1 are associated by weak cooperative O-H…N, O-H…S and N-H…S hydrogen bonds resulting in a 3D network structure. The compound is redox active and shows luminescence in MeOH solution. Thermal decomposition pattern of 1 reveals the presence of two coordinated water molecules. Variabletemperature magnetic susceptibility measurement shows significant orbital contribution and numerical matrix diagonalization method gives the best fit parameters: = A∗k = 1.43; = −130 cm-1; = −864 cm-1; TIP = 0.000975; R = 1.19 × 10−4.

  9. Rhein-Ruhr architecture

    DEFF Research Database (Denmark)

    2002-01-01

    katalog til udstillingen 'Rhein - Ruhr architecture' Meldahls smedie, 15. marts - 28. april 2002. 99 sider......katalog til udstillingen 'Rhein - Ruhr architecture' Meldahls smedie, 15. marts - 28. april 2002. 99 sider...

  10. Bioclimatism in vernacular architecture

    OpenAIRE

    Coch Roura, Helena

    1998-01-01

    Any analysis of the role played by energy in architecture is faced with serious limitations due to the lack of studies in the architectural bibliography, especially studies of popular architecture. An awareness of these limitations will allow us to understand better why architects have paid little attention to the interaction of form and energy, and to the bioclimatic approach in contemporary architecture in general. The first limitation stems from the very essence of bioclimatic analysis; en...

  11. Controller Architectures for Switching

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2009-01-01

    This paper investigate different controller architectures in connection with controller switching. The controller switching is derived by using the Youla-Jabr-Bongiorno-Kucera (YJBK) parameterization. A number of different architectures for the implementation of the YJBK parameterization are...... described and applied in connection with controller switching. An architecture that does not include inversion of the coprime factors is introduced. This architecture will make controller switching particular simple....

  12. School of Architecture + Design establishes Virginia Tech architecture publications

    OpenAIRE

    Chadwick, Heather Riley

    2007-01-01

    Virginia Tech's School of Architecture + Design, in the College of Architecture and Urban Studies, with the initiative of Markus Breitschmid, assistant professor of architecture, has established Virginia Tech Architecture Publications.

  13. Architectural Knitted Surfaces

    DEFF Research Database (Denmark)

    Mossé, Aurélie

    2010-01-01

    WGSN reports from the Architectural Knitted Surfaces workshop recently held at ShenkarCollege of Engineering and Design, Tel Aviv, which offered a cutting-edge insight into interactive knitted surfaces. With the increasing role of smart textiles in architecture, the Architectural Knitted Surfaces...

  14. EAP high-level product architecture

    DEFF Research Database (Denmark)

    Guðlaugsson, Tómas Vignir; Mortensen, Niels Henrik; Sarban, Rahimullah

    2013-01-01

    EAP technology products while keeping complexity under control. High level product architecture has been developed for the mechanical part of EAP transducers, as the foundation for platform development. A generic description of an EAP transducer forms the core of the high level product architecture....... This description breaks down the EAP transducer into organs that perform the functions that may be present in an EAP transducer. A physical instance of an EAP transducer contains a combination of the organs needed to fulfill the task of actuator, sensor, and generation. Alternative principles for each...... organ allow the function of the EAP transducers to be changed, by basing the EAP transducers on a different combination of organ alternatives. A model providing an overview of the high level product architecture has been developed to support daily development and cooperation across development teams...

  15. The brand architecture of grocery retailers

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Esbjerg, Lars

    2009-01-01

    This article discusses how the brand architecture of grocery retailers set material and symbolic boundaries for consumer choice, thus limiting consumer sovereignty. The article first discusses previous work on store atmospherics, servicescapes and brand architecture. It is argued that work based on...... these concepts has taken an internal management perspective on how retailers can manipulate aspects of the retail setting to serve their own interests. Then, we develop an alternative conceptualisation of retailer brand architecture that takes into account that consumers (and other constituents) are...... active co- constructors of material and symbolic aspects of retail settings. It is discussed how consumers participate in constructing retailer brand architecture and how this concept differs from previous research. Implications for both research and practice are discussed....

  16. Assessing Random Dynamical Network Architectures for Nanoelectronics

    CERN Document Server

    Teuscher, Christof; Rohlf, Thimo

    2008-01-01

    Independent of the technology, it is generally expected that future nanoscale devices will be built from vast numbers of densely arranged devices that exhibit high failure rates. Other than that, there is little consensus on what type of technology and computing architecture holds most promises to go far beyond today's top-down engineered silicon devices. Cellular automata (CA) have been proposed in the past as a possible class of architectures to the von Neumann computing architecture, which is not generally well suited for future parallel and fine-grained nanoscale electronics. While the top-down engineered semi-conducting technology favors regular and locally interconnected structures, future bottom-up self-assembled devices tend to have irregular structures because of the current lack precise control over these processes. In this paper, we will assess random dynamical networks, namely Random Boolean Networks (RBNs) and Random Threshold Networks (RTNs), as alternative computing architectures and models for...

  17. Vital architecture, slow momentum policy

    DEFF Research Database (Denmark)

    Braae, Ellen Marie

    2010-01-01

    A reflection on the relation between Danish landscape architecture policy and the statements made through current landscape architectural project.......A reflection on the relation between Danish landscape architecture policy and the statements made through current landscape architectural project....

  18. Automatic Hardware Generation for Reconfigurable Architectures

    NARCIS (Netherlands)

    Nane, R.

    2014-01-01

    Reconfigurable Architectures (RA) have been gaining popularity rapidly in the last decade for two reasons. First, processor clock frequencies reached threshold values past which power dissipation becomes a very difficult problem to solve. As a consequence, alternatives were sought to keep improving

  19. Software architecture evolution

    DEFF Research Database (Denmark)

    Barais, Olivier; Le Meur, Anne-Francoise; Duchien, Laurence;

    2008-01-01

    Software architectures must frequently evolve to cope with changing requirements, and this evolution often implies integrating new concerns. Unfortunately, when the new concerns are crosscutting, existing architecture description languages provide little or no support for this kind of evolution....... The software architect must modify multiple elements of the architecture manually, which risks introducing inconsistencies. This chapter provides an overview, comparison and detailed treatment of the various state-of-the-art approaches to describing and evolving software architectures. Furthermore, we...... discuss one particular framework named Tran SAT, which addresses the above problems of software architecture evolution. Tran SAT provides a new element in the software architecture descriptions language, called an architectural aspect, for describing new concerns and their integration into an existing...

  20. Molecular architecture of organic-inorganic polymers

    Czech Academy of Sciences Publication Activity Database

    Matějka, Libor

    Dresden : Max Planck Institute for the Physic of Complex Systems, 2005. [MPG-MOEL– Symposium: Science and Art in Europe, Polymers: Materials in Nature and in Advanced Technologies. 23.5.2005-25.5.2005, Dresden] R&D Projects: GA ČR(CZ) GA203/05/2252 Keywords : organic-inorganic polymers * morphology Subject RIV: CD - Macromolecular Chemistry

  1. Design of molecular architectures to mimic photosynthesis

    International Nuclear Information System (INIS)

    Our researches on photo-induced energy or electron transfer for artificial photosynthesis relies on the utilization of conjugated spacers to perform these two processes over long distance. This article describes the synthesis and the characterization of dyads composed of a tris-bipyridine ruthenium complex as sensitizer, a fullerene or a naphthalene bis-imide as acceptor and a oligo(phenylene-ethynylene) as spacer. These systems exhibit electron or energy transfer from the excited state of the ruthenium complex to the acceptor. (authors)

  2. Nanorobot architecture for medical target identification

    International Nuclear Information System (INIS)

    This work has an innovative approach for the development of nanorobots with sensors for medicine. The nanorobots operate in a virtual environment comparing random, thermal and chemical control techniques. The nanorobot architecture model has nanobioelectronics as the basis for manufacturing integrated system devices with embedded nanobiosensors and actuators, which facilitates its application for medical target identification and drug delivery. The nanorobot interaction with the described workspace shows how time actuation is improved based on sensor capabilities. Therefore, our work addresses the control and the architecture design for developing practical molecular machines. Advances in nanotechnology are enabling manufacturing nanosensors and actuators through nanobioelectronics and biologically inspired devices. Analysis of integrated system modeling is one important aspect for supporting nanotechnology in the fast development towards one of the most challenging new fields of science: molecular machines. The use of 3D simulation can provide interactive tools for addressing nanorobot choices on sensing, hardware architecture design, manufacturing approaches, and control methodology investigation

  3. Evolution of plant genome architecture.

    Science.gov (United States)

    Wendel, Jonathan F; Jackson, Scott A; Meyers, Blake C; Wing, Rod A

    2016-01-01

    We have witnessed an explosion in our understanding of the evolution and structure of plant genomes in recent years. Here, we highlight three important emergent realizations: (1) that the evolutionary history of all plant genomes contains multiple, cyclical episodes of whole-genome doubling that were followed by myriad fractionation processes; (2) that the vast majority of the variation in genome size reflects the dynamics of proliferation and loss of lineage-specific transposable elements; and (3) that various classes of small RNAs help shape genomic architecture and function. We illustrate ways in which understanding these organism-level and molecular genetic processes can be used for crop plant improvement. PMID:26926526

  4. BUILDING SUSTAINABLE ARCHITECTURAL DESIGN: A RENOVATION PROJECT

    Directory of Open Access Journals (Sweden)

    Hakan ÜNALAN,

    2011-12-01

    Full Text Available Today, the conservation of energy and respect for the natural environment appears to be the most important phenomena in all areas. In this regard, "sustainability" concept emerged and the architectural platform "Sustainable Architecture" is composed of a research subject to the new and permanent. Architecture underlying the "design" as including also the new concept of "sustainable architectural design" has revealed that field. Sustainable architecture "building in-house", "building envelope" and "physical environment" as shown in three different areas of development. Each consisting of three fields that directly affect andconcern. Sustainable architectural design within the scope of this study, "Building Envelope" developments will be discussed. In this context, building envelope, "the new building design" and "existingstructures" as appeared in two different ways. Existing structures, building envelope, sustainable architectural design in the literature in terms of "renovation" is considered within the scope. In terms of energy efficiency and performance (as Energy Performance of Buildings [BEP] with the energy policies of the various measures are being taken to reduce the energy consumption of the new building design. Not been received, but no measures in existing buildings (apartment buildings until 2012, except for heat insulation Remodeling obligation, energy consumption has remained constant. Therefore, the energy consumption of buildings on a sectoral basis is changing in the range 36-25% share of the portion of (Anonim 2011, but can not be reduced. In addition, operating costs of existing buildings and to reduce reliance on energy-environment systems (except for collectors used is noteworthy. In this study the appropriate design of sustainable architecture, renewable energy systems can be integrated into the shell structure will be investigated. In this context, a renovation project of the Department of Architecture at Anadolu

  5. Using Software Architectures for Designing Distributed Embedded Systems

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    In this paper, we outline an on-going project of designing distributed embedded systems for closed-loop process control. The project is a joint effort between software architecture researchers and developers from two companies that produce commercial embedded process control systems. The project...... has a strong emphasis on software architectural issues and terminology in order to envision, design and analyze design alternatives. We present two results. First, we outline how focusing on software architecture, architectural issues and qualities are beneficial in designing distributed, embedded...

  6. Cell broadband engine architecture as a DSP platform

    Science.gov (United States)

    Szumski, Karol; Malanowski, Mateusz

    2009-06-01

    The slowing pace of performance improvement in the commonly available processors is a cause of concern amongst many computational scientists. This combined with the ever increasing need for computational power has caused us to turn to alternative architectures in search of performance gains. Two main candidates were the Compute Unified Device Architecture (CUDA) and the Cell Broadband Engine (CELL BE) architecture. This paper focuses on the latter, outlining the architecture and basic programming paradigms, and also contains performance comparison of algorithms currently developed by our team.

  7. Architecture and Stages

    DEFF Research Database (Denmark)

    Kiib, Hans

    2009-01-01

    future. But this is not enough. The agenda is to develop architectural spaces, where social interaction and learning are enhanced by art and fun. How can we develop new architectural designs in our inner cities and waterfronts where eventscapes, learning labs and temporal use are merged with everyday......Architecture and Art as Fuel New development zones for shopping and entertainment and space for festivals inside the city CAN be coupled with art and architecture and become ‘open minded' public domains based on cultural exchange and mutual learning. This type of space could be labelled as...... "experiencescape" - a space between tourism, culture, learning and economy. Strategies related to these challenges involve new architectural concepts and art as ‘engines' for a change. New expressive architecture and old industrial buildings are often combined into hybrid narratives, linking the past with the...

  8. Architecture humanitarian emergencies

    DEFF Research Database (Denmark)

    Gomez-Guillamon, Maria; Eskemose Andersen, Jørgen; Contreras, Jorge Lobos;

    2013-01-01

    Introduced by scientific articles conserning architecture and human rights in light of cultures, emergencies, social equality and sustainability, democracy, economy, artistic development and science into architecture. Concluding in definition of needs for new roles, processes and education of...... architecture. Followed by articles focusing on interdisciplinary research and design of emergency shelters as well as educational environments. Finally concretized in 35 studies from international workshops arranged globally on and by different architect schools: Royal Danish Academy of Fine Arts in Denmark...

  9. Discovery Food - Culinary Architecture

    OpenAIRE

    Buettner-Graefenhain, Christine

    2005-01-01

    What keeps places unique in times of globalization? If information, goods, food, architecture are the same everywhere, what`s the difference between places? What are people identifying with? Eating habits are a main factor of cultural identification. How can architecture contribute to these feelings of belonging, self awareness and joy? How can it teach something about the place and the people living there? What if a new kind of culinary architecture can help opening people`s e...

  10. An Architecture for Autonomy

    OpenAIRE

    Alami, Rachid; Chatila, Raja; Fleury, Sara; Ghallab, Malik; Ingrand, Félix

    1998-01-01

    International audience An autonomous robot offers a challenging and ideal field for the study of intelligent architectures. Autonomy within a rational behavior could be evaluated by the robot's effectiveness and robustness in carrying out tasks in different and ill-known environments_ It raises major requirements on the control architecture. Furthermore, a robot as a programmable machine brings up other architectural needs, such as the ease and quality of its speci_cation and programming. ...

  11. Architecture Criticism Blindfolded

    OpenAIRE

    Ann Heylighen; Jasmien Herssens; Hubert Froyen

    2009-01-01

    The paper reports on a recent Belgian initiative targeting architectural practice through the professional press. Architecture critics were invited to revisit an exemplary public building while being blindfolded and guided by persons who are visually impaired. Afterwards, they were asked to report on this visit in an article for an architectural magazine. The initiative aimed at drawing the attention of the critics—and, by extension, the readers of their articles—to the need for accessibil...

  12. World Ships - Architectures & Feasibility Revisited

    Science.gov (United States)

    Hein, A. M.; Pak, M.; Putz, D.; Buhler, C.; Reiss, P.

    A world ship is a concept for manned interstellar flight. It is a huge, self-contained and self-sustained interstellar vehicle. It travels at a fraction of a per cent of the speed of light and needs several centuries to reach its target star system. The well- known world ship concept by Alan Bond and Anthony Martin was intended to show its principal feasibility. However, several important issues haven't been addressed so far: the relationship between crew size and robustness of knowledge transfer, reliability, and alternative mission architectures. This paper addresses these gaps. Furthermore, it gives an update on target star system choice, and develops possible mission architectures. The derived conclusions are: a large population size leads to robust knowledge transfer and cultural adaptation. These processes can be improved by new technologies. World ship reliability depends on the availability of an automatic repair system, as in the case of the Daedalus probe. Star systems with habitable planets are probably farther away than systems with enough resources to construct space colonies. Therefore, missions to habitable planets have longer trip times and have a higher risk of mission failure. On the other hand, the risk of constructing colonies is higher than to establish an initial settlement on a habitable planet. Mission architectures with precursor probes have the potential to significantly reduce trip and colonization risk without being significantly more costly than architectures without. In summary world ships remain an interesting concept, although they require a space colony-based civilization within our own solar system before becoming feasible.

  13. Architecture of Network Systems

    CERN Document Server

    Serpanos, Dimitrios

    2011-01-01

    Network systems require technical skills in computer architecture, design methodologies, algorithm design, and networking. Architecture of Network Systems explains the practice and methodologies that will allow you to solve a broad range of problems in system design, including problems related to security, quality of service, performance, manageability, and more. Leading researchers Dimitrios Serpanos and Tilman Wolf develop architectures for all network sub-systems, bridging the gap between operation and VLSI. Discussing the major challenges in the design of networks and the architectures tha

  14. IT Architecture For Dummies

    CERN Document Server

    Hausman, Kalani Kirk

    2010-01-01

    A solid introduction to the practices, plans, and skills required for developing a smart system architecture. Information architecture combines IT skills with business skills in order to align the IT structure of an organization with the mission, goals, and objectives of its business. This friendly introduction to IT architecture walks you through the myriad issues and complex decisions that many organizations face when setting up IT systems to work in sync with business procedures. Veteran IT professional and author Kirk Hausman explains the business value behind IT architecture and provides

  15. Grid Architecture 2

    Energy Technology Data Exchange (ETDEWEB)

    Taft, Jeffrey D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-01-01

    The report describes work done on Grid Architecture under the auspices of the Department of Electricity Office of Electricity Delivery and Reliability in 2015. As described in the first Grid Architecture report, the primary purpose of this work is to provide stakeholder insight about grid issues so as to enable superior decision making on their part. Doing this requires the creation of various work products, including oft-times complex diagrams, analyses, and explanations. This report provides architectural insights into several important grid topics and also describes work done to advance the science of Grid Architecture as well.

  16. Molecular Analysis of Alternative Transcripts of the Equine Cordon-Bleu WH2 Repeat Protein-Like 1 (COBLL1) Gene.

    Science.gov (United States)

    Park, Jeong-Woong; Jang, Hyun-Jun; Shin, Sangsu; Cho, Hyun-Woo; Choi, Jae-Young; Kim, Nam-Young; Lee, Hak-Kyo; Do, Kyong-Tak; Song, Ki-Duk; Cho, Byung-Wook

    2015-06-01

    The purpose of this study was to investigate the alternative splicing in equine cordon-bleu WH2 repeat protein-like 1 (COBLL1) gene that was identified in horse muscle and blood leukocytes, and to predict functional consequences of alternative splicing by bioinformatics analysis. In a previous study, RNA-seq analysis predicted the presence of alternative spliced isoforms of equine COBLL1, namely COBLL1a as a long form and COBLL1b as a short form. In this study, we validated two isoforms of COBLL1 transcripts in horse tissues by the real-time polymerase chain reaction, and cloned them for Sanger sequencing. The sequencing results showed that the alternative splicing occurs at exon 9. Prediction of protein structure of these isoforms revealed three putative phosphorylation sites at the amino acid sequences encoded in exon 9, which is deleted in COBLL1b. In expression analysis, it was found that COBLL1b was expressed ubiquitously and equivalently in all the analyzed tissues, whereas COBLL1a showed strong expression in kidney, spinal cord and lung, moderate expression in heart and skeletal muscle, and low expression in thyroid and colon. In muscle, both COBLL1a and COBLL1b expression decreased after exercise. It is assumed that the regulation of COBLL1 expression may be important for regulating glucose level or switching of energy source, possibly through an insulin signaling pathway, in muscle after exercise. Further study is warranted to reveal the functional importance of COBLL1 on athletic performance in race horses. PMID:25925064

  17. Architecture for Survivable System Processing (ASSP)

    Science.gov (United States)

    Wood, Richard J.

    1991-11-01

    The Architecture for Survivable System Processing (ASSP) Program is a multi-phase effort to implement Department of Defense (DOD) and commercially developed high-tech hardware, software, and architectures for reliable space avionics and ground based systems. System configuration options provide processing capabilities to address Time Dependent Processing (TDP), Object Dependent Processing (ODP), and Mission Dependent Processing (MDP) requirements through Open System Architecture (OSA) alternatives that allow for the enhancement, incorporation, and capitalization of a broad range of development assets. High technology developments in hardware, software, and networking models, address technology challenges of long processor life times, fault tolerance, reliability, throughput, memories, radiation hardening, size, weight, power (SWAP) and security. Hardware and software design, development, and implementation focus on the interconnectivity/interoperability of an open system architecture and is being developed to apply new technology into practical OSA components. To insure for widely acceptable architecture capable of interfacing with various commercial and military components, this program provides for regular interactions with standardization working groups (e.g.) the International Standards Organization (ISO), American National Standards Institute (ANSI), Society of Automotive Engineers (SAE), and Institute of Electrical and Electronic Engineers (IEEE). Selection of a viable open architecture is based on the widely accepted standards that implement the ISO/OSI Reference Model.

  18. Multicore technology architecture, reconfiguration, and modeling

    CERN Document Server

    Qadri, Muhammad Yasir

    2013-01-01

    The saturation of design complexity and clock frequencies for single-core processors has resulted in the emergence of multicore architectures as an alternative design paradigm. Nowadays, multicore/multithreaded computing systems are not only a de-facto standard for high-end applications, they are also gaining popularity in the field of embedded computing. The start of the multicore era has altered the concepts relating to almost all of the areas of computer architecture design, including core design, memory management, thread scheduling, application support, inter-processor communication, debu

  19. Digitally-Driven Architecture

    Directory of Open Access Journals (Sweden)

    Henriette Bier

    2010-06-01

    Full Text Available The shift from mechanical to digital forces architects to reposition themselves: Architects generate digital information, which can be used not only in designing and fabricating building components but also in embedding behaviours into buildings. This implies that, similar to the way that industrial design and fabrication with its concepts of standardisation and serial production influenced modernist architecture, digital design and fabrication influences contemporary architecture. While standardisa­tion focused on processes of rationalisation of form, mass-customisation as a new paradigm that replaces mass-production, addresses non-standard, complex, and flexible designs. Furthermore, knowledge about the designed object can be encoded in digital data pertaining not just to the geometry of a design but also to its physical or other behaviours within an environment. Digitally-driven architecture implies, therefore, not only digitally-designed and fabricated architecture, it also implies architecture – built form – that can be controlled, actuated, and animated by digital means. In this context, this sixth Footprint issue examines the influence of digital means as prag­matic and conceptual instruments for actuating architecture. The focus is not so much on computer-based systems for the development of architectural designs, but on architecture incorporating digital control, sens­ing, actuating, or other mechanisms that enable buildings to inter­act with their users and surroundings in real time in the real world through physical or sensory change and variation.

  20. Digitally-Driven Architecture

    Directory of Open Access Journals (Sweden)

    Henriette Bier

    2014-07-01

    Full Text Available The shift from mechanical to digital forces architects to reposition themselves: Architects generate digital information, which can be used not only in designing and fabricating building components but also in embedding behaviours into buildings. This implies that, similar to the way that industrial design and fabrication with its concepts of standardisation and serial production influenced modernist architecture, digital design and fabrication influences contemporary architecture. While standardisation focused on processes of rationalisation of form, mass-customisation as a new paradigm that replaces mass-production, addresses non-standard, complex, and flexible designs. Furthermore, knowledge about the designed object can be encoded in digital data pertaining not just to the geometry of a design but also to its physical or other behaviours within an environment. Digitally-driven architecture implies, therefore, not only digitally-designed and fabricated architecture, it also implies architecture – built form – that can be controlled, actuated, and animated by digital means.In this context, this sixth Footprint issue examines the influence of digital means as pragmatic and conceptual instruments for actuating architecture. The focus is not so much on computer-based systems for the development of architectural designs, but on architecture incorporating digital control, sens­ing, actuating, or other mechanisms that enable buildings to inter­act with their users and surroundings in real time in the real world through physical or sensory change and variation.

  1. Clinical document architecture.

    Science.gov (United States)

    Heitmann, Kai

    2003-01-01

    The Clinical Document Architecture (CDA), a standard developed by the Health Level Seven organisation (HL7), is an ANSI approved document architecture for exchange of clinical information using XML. A CDA document is comprised of a header with associated vocabularies and a body containing the structural clinical information. PMID:15061557

  2. Software Architecture Evolution

    Science.gov (United States)

    Barnes, Jeffrey M.

    2013-01-01

    Many software systems eventually undergo changes to their basic architectural structure. Such changes may be prompted by new feature requests, new quality attribute requirements, changing technology, or other reasons. Whatever the causes, architecture evolution is commonplace in real-world software projects. Today's software architects, however,…

  3. Towards a Media Architecture

    DEFF Research Database (Denmark)

    Ebsen, Tobias

    2010-01-01

    This text explores the concept of media architecture as a phenomenon of visual culture that describes the use of screen-technology in new spatial configurations in practices of architecture and art. I shall argue that this phenomenon is not necessarily a revolutionary new approach, but rather...

  4. Workflow automation architecture standard

    Energy Technology Data Exchange (ETDEWEB)

    Moshofsky, R.P.; Rohen, W.T. [Boeing Computer Services Co., Richland, WA (United States)

    1994-11-14

    This document presents an architectural standard for application of workflow automation technology. The standard includes a functional architecture, process for developing an automated workflow system for a work group, functional and collateral specifications for workflow automation, and results of a proof of concept prototype.

  5. Architecture or Sculpture?

    DEFF Research Database (Denmark)

    Baumeister, Ruth

    Jørn Utzon´s museum design for Asger Jorn´s collection in Silkeborg contextualized in the postwar context of an organic architecture.......Jørn Utzon´s museum design for Asger Jorn´s collection in Silkeborg contextualized in the postwar context of an organic architecture....

  6. Architecture and energy

    DEFF Research Database (Denmark)

    Marsh, Rob; Lauring, Michael

    2011-01-01

    Traditional low-energy architecture has not necessarily led to reduced energy consumption. A paradigm shift is proposed promoting pluralistic energy-saving strategies.......Traditional low-energy architecture has not necessarily led to reduced energy consumption. A paradigm shift is proposed promoting pluralistic energy-saving strategies....

  7. Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus): Molecular and functional characterization and immune responsive mRNA expression analysis.

    Science.gov (United States)

    Godahewa, G I; Perera, N C N; Bathige, S D N K; Nam, Bo-Hye; Noh, Jae Koo; Lee, Jehee

    2016-08-01

    The complement system serves conventional role in the innate defense against common invading pathogens. Complement factor D (CfD) is vital to alternative complement pathway activation in cleaving complement factor B. This catalytic reaction forms the alternative C3 convertase that is crucial for complement-mediated pathogenesis. In this study, rock bream (Oplegnathus fasciatus) CfD (OfCfD) was characterized and OfCfD mRNA expression was investigated. OfCfD encodes 277 amino acids (aa) for a 30-kDa polypeptide. A domain analysis of the deduced OfCfD aa sequence showed a single serine protease trypsin superfamily domain, a serine active region, three active sites, and three substrate-binding sites. Pairwise sequence comparisons indicated that OfCfD has the highest identity (84.5%) with Oreochromis niloticus CfD. The phylogenetic tree revealed a common ancestral origin of CfD members, with fish CfD distinct from other vertebrate orthologs. The structural arrangement of the OfCfD gene (2451 bp) contained five exons interrupted by four introns. A spatial transcriptional analysis indicated that OfCfD transcripts constitutively expressed in all of the examined rock bream tissues, and that they were highest in the spleen and liver. In addition, OfCfD transcripts were immunologically upregulated by lipopolysaccharide (LPS) (12 h p.i.), Streptococcus iniae (12 h p.i.), rock bream iridovirus (RBIV) (6-12 h p.i.), and poly I:C (6 h p.i.) in spleen tissue. OfCfD is a trypsin protease and its recombinant protein showed strong protease activity similar to that of trypsin, indicating its catalytic function in the alternative pathway. Together, our findings suggest that OfCfD might be involved in immune responses in rock bream. PMID:27311435

  8. A catalog of architectural primitives for modeling architectural patterns

    NARCIS (Netherlands)

    Zdun, Uwe; Avgeriou, Paris

    2008-01-01

    Architectural patterns are a fundamental aspect of the architecting process and subsequently the architectural documentation. Unfortunately, there is only poor support for modeling architectural patterns for two reasons. First, patterns describe recurring design solutions and hence do not directly m

  9. Architecture as Ars Combinatoria

    Directory of Open Access Journals (Sweden)

    Francesco Cacciatore

    2015-11-01

    Full Text Available Architecture today, no longer reflects the limits of experimentation and innovation. An extremely low-tech art whose field of possibilities consists of choosing and using that which has already been done in the past. It is because of this that the key skill a designer should have is the ability to recognize the complexity in forms around them: cities have the widest programming opportunities for architecture, in the two-way relationship that is established from the city that takes form in architecture and an architecture that finds its place in the contemporary city. Thus, architecture has its foundation in hospitality, an element that differentiates it significantly from the design.

  10. Product Architecture Modularity Strategies

    DEFF Research Database (Denmark)

    Mikkola, Juliana Hsuan

    2003-01-01

    The focus of this paper is to integrate various perspectives on product architecture modularity into a general framework, and also to propose a way to measure the degree of modularization embedded in product architectures. Various trade-offs between modular and integral product architectures and...... how components and interfaces influence the degree of modularization are considered. In order to gain a better understanding of product architecture modularity as a strategy, a theoretical framework and propositions are drawn from various academic literature sources. Based on the literature review......, the following key elements of product architecture are identified: components (standard and new-to-the-firm), interfaces (standardization and specification), degree of coupling, and substitutability. A mathematical function, termed modularization function, is introduced to measure the degree of...

  11. ARCHITECTURE IN THE ISLAMIC CIVILIZATION: MUSLIM BUILDING OR ISLAMIC ARCHITECTURE

    OpenAIRE

    Ayat Ali Yassin; Dr. Nangkula Utaberta

    2012-01-01

    The main problem of the theory in the arena of islamic architecture is affected by some of its Westernthoughts, and stereotyping the islamic architecture according to Western thoughts; this leads to the breakdownof the foundations in the islamic architecture. It is a myth that islamic architecture is subjected to theinfluence from foreign architectures. This paper will highlight the dialectical concept of islamic architecture ormuslim buildings and the areas of recognition in islamic architec...

  12. Analysis of Architecture Pattern Usage in Legacy System Architecture Documentation

    OpenAIRE

    Harrison, Neil B.; Avgeriou, Paris

    2008-01-01

    Architecture patterns are an important tool in architectural design. However, while many architecture patterns have been identified, there is little in-depth understanding of their actual use in software architectures. For instance, there is no overview of how many patterns are used per system or which patterns are the most common or most important for particular domains. In addition, little is known of how architecture patterns may interact with each other. We studied architecture documentat...

  13. Prueba molecular Genotype® MTBDRplus, una alternativa para la detección rápida de tuberculosis multidrogorresistente Molecular test Genotype® MTBDRplus, an alternative to rapid detection of multidrug resistance tuberculosis

    Directory of Open Access Journals (Sweden)

    Luis Asencios

    2012-03-01

    Full Text Available La prueba molecular Genotype®MTBDRplus, es un método que permite identificar las mutaciones más frecuentes asociadas con la resistencia a las drogas antituberculosas de primera línea: isoniacida (INH y rifampicina (RIF. El objetivo de este estudio fue evaluar el desempeño de la prueba molecular con cultivos y muestras de esputo con baciloscopía positiva. Se evaluó 95 cultivos y 100 esputos con perfiles de resistencia previamente determinados por el método de referencia "proporciones agar en placa" (APP. La prueba molecular a partir de cultivos mostró una sensibilidad de 100%; 97,5% y 96,9% para RIF, INH y multidrogorresistente (MDR respectivamente; mientras que para esputo la sensibilidad fue de 95,7%; 96,8% y 95,2% para RIF, INH y MDR respectivamente. Se concluye que Genotype®MTBDRplus es una herramienta muy útil para la detección rápida de la resistencia a INH y RIF simultáneamente (MDR en un máximo de 72 h a partir de esputo o de cultivo.The Genotype®MTBDRplus molecular test is a method that allows identification of the most frequent mutations associated with resistance to major first-line antituberculosis drugs, Isoniazid (INH and Rifampicin (RFP. The aim of this study was to evaluate the performance of the molecular test with culture and smear- positive sputum samples. We evaluated 95 cultures and 100 sputum samples with resistance profiles previously determined by the reference method "Agar Plate Proportions" (APP. The molecular test from cultures showed a sensitivity of 100 %, 97,5 % and 96,97 % for RIF, INH and MDR respectively while from sputums the sensitivity was 95,65 %, 96,77 % and 95,24 % for RIF, INH and MDR respectively. We conclude that the molecular test Genotype®MTBDRplus is a very useful tool to detect resistance to isoniazid and rifampicin simultaneously (MDR-TB in up to 72 hours from sputum samples or cultures.

  14. Architecture in the Experience City

    DEFF Research Database (Denmark)

    Kiib, Hans

    narratives related to historical buildings and architectural heritage; another group tries to embed new performative technologies in expressive architectural representation. The article provides a theoretical framework for the analysis of the political rationales of these projects and for the architectural...

  15. Modeling corrosion inhibition efficacy of small organic molecules as non-toxic chromate alternatives using comparative molecular surface analysis (CoMSA).

    Science.gov (United States)

    Fernandez, Michael; Breedon, Michael; Cole, Ivan S; Barnard, Amanda S

    2016-10-01

    Traditionally many structural alloys are protected by primer coatings loaded with corrosion inhibiting additives. Strontium Chromate (or other chromates) have been shown to be extremely effectively inhibitors, and find extensive use in protective primer formulations. Unfortunately, hexavalent chromium which imbues these coatings with their corrosion inhibiting properties is also highly toxic, and their use is being increasingly restricted by legislation. In this work we explore a novel tridimensional Quantitative-Structure Property Relationship (3D-QSPR) approach, comparative molecular surface analysis (CoMSA), which was developed to recognize "high-performing" corrosion inhibitor candidates from the distributions of electronegativity, polarizability and van der Waals volume on the molecular surfaces of 28 small organic molecules. Multivariate statistical analysis identified five prototypes molecules, which are capable of explaining 71% of the variance within the inhibitor data set; whilst a further five molecules were also identified as archetypes, describing 75% of data variance. All active corrosion inhibitors, at a 80% threshold, were successfully recognized by the CoMSA model with adequate specificity and precision higher than 70% and 60%, respectively. The model was also capable of identifying structural patterns, that revealed reasonable starting points for where structural changes may augment corrosion inhibition efficacy. The presented methodology can be applied to other functional molecules and extended to cover structure-activity studies in a diverse range of areas such as drug design and novel material discovery. PMID:27362530

  16. Evolution of contemporary museum architecture

    OpenAIRE

    Bilous, Yulia

    2013-01-01

    This article deals with the development of museum architecture from the formation of the classic building architecture to the establishment of the contemporary museum architecture. Changes in the museum building architecture and displaying principles have been analysed. The 19th century was defined by the emergence of a vast number of museums serving through present as examples of the contemporary museum architecture. New styles are tried in the museum architecture alo...

  17. Hybrid architecture: object, landscape, infrastructure

    OpenAIRE

    Pinto de Freitas, Rita

    2011-01-01

    The concept of "hybrid architecture" developed in this study considers hybrid all architecture that is at once object, landscape and infrastructure. Hybrid architecture, pushed by the fact that it concentrates in a single architectural intervention a triple object-, landscape- and infrastructure-related nature, generates architectural answers with very specific features, and its study achieves following goals: 1: Clarify the term hybrid related to architectural intervention; 2: Tran...

  18. Business Capabilities Centric Enterprise Architecture

    OpenAIRE

    Barroero, Thiago; Motta, Gianmario; Pignatelli, Giovanni

    2010-01-01

    In the field of Enterprise Architecture, The Open Group Architecture Framework (TOGAF) is a well known framework, that links Business Architecture, Data Architecture, Application Architecture, Technology. A key concept within Business Architecture domain is Business Capabilities, that are delivered by Business Component (BC). A BC is a business unit that encompasses a coherent set of activities, supported by assets including people, processes and technology. Current TOGAF version recognizes t...

  19. Data-Centric Enterprise Architecture

    OpenAIRE

    Zeinab Rajabi; Maryam Nooraei Abade

    2012-01-01

    Enterprises choose Enterprise Architecture (EA) solution, in order to overcome dynamic business challenges and in coordinate various enterprise elements. In this article, a solution is suggested for the Enterprise Architecture development. The solution focuses on architecture data in the Enterprise Architecture development process. Data-centric architecture approach is preferred product-centric architecture approach. We suggest using Enterprise Ontology (EO) as context for collecting architec...

  20. Alternative Treatments

    Science.gov (United States)

    ... Find your chapter: search by state Home > Alzheimer's Disease > Treatments > Alternative Treatments Overview What Is Dementia? What Is Alzheimer's? Younger/Early Onset Facts and Figures Know the 10 Signs Stages Inside the Brain: ...

  1. On Detailing in Contemporary Architecture

    DEFF Research Database (Denmark)

    Kristensen, Claus; Kirkegaard, Poul Henning

    Details in architecture have a significant influence on how architecture is experienced. One can touch the materials and analyse the detailing - thus details give valuable information about the architectural scheme as a whole. The absence of perceptual stimulation like details and materiality...... / tactility can blur the meaning of the architecture and turn it into an empty statement. The present paper will outline detailing in contemporary architecture and discuss the issue with respect to architectural quality. Architectural cases considered as sublime piece of architecture will be presented and...... discussed with respect to the meaning of detailing....

  2. Integrated Data Assimilation Architecture Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Data Assimilation Architecture (IDAA) is a middleware architecture that facilitates the incorporation of heterogeneous sensing and control devices...

  3. Avionics Architecture for Exploration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Avionics Architectures for Exploration Project team will develop a system level environment and architecture that will accommodate equipment from multiple...

  4. Computer architecture technology trends

    CERN Document Server

    1991-01-01

    Please note this is a Short Discount publication. This year's edition of Computer Architecture Technology Trends analyses the trends which are taking place in the architecture of computing systems today. Due to the sheer number of different applications to which computers are being applied, there seems no end to the different adoptions which proliferate. There are, however, some underlying trends which appear. Decision makers should be aware of these trends when specifying architectures, particularly for future applications. This report is fully revised and updated and provides insight in

  5. Architecture, energy and climate

    DEFF Research Database (Denmark)

    Lauring, Michael

    2010-01-01

    Architecture has always had to relate to climatic conditions while providing shelter from the sun, the rain, the winds or the cold. This is a main purpose of buildings: To establish an indoor climate different from the outdoor. In the Nordic countries fuels for heating buildings has been a vital...... cases been to search for traditional and pre-industrialized ways of building and settlement. The idea of this theme number is not to flee from modern life and approaches, but instead to face modern conditions relevant in achieving sustainable urban development and sustainable architecture, the only...... truly modern architecture that exists....

  6. Architecture for Verifiable Software

    Science.gov (United States)

    Reinholtz, William; Dvorak, Daniel

    2005-01-01

    Verifiable MDS Architecture (VMA) is a software architecture that facilitates the construction of highly verifiable flight software for NASA s Mission Data System (MDS), especially for smaller missions subject to cost constraints. More specifically, the purpose served by VMA is to facilitate aggressive verification and validation of flight software while imposing a minimum of constraints on overall functionality. VMA exploits the state-based architecture of the MDS and partitions verification issues into elements susceptible to independent verification and validation, in such a manner that scaling issues are minimized, so that relatively large software systems can be aggressively verified in a cost-effective manner.

  7. RECONSTRUCTING DECONSTRUCTION IN ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    IDHAM Noor Cholis

    2013-01-01

    Full Text Available This paper examines deconstruction in architecture and forms used, which triggered by dispute of form and its scientification claimed by deconstructivists. Deconstruction terminologyis studied in the first part related to architecture field as a base knowledge. Some sample works of known deconstructionist architects are assessed in order to understand how their building is deconstructed and what forms they used. Discussion about form and its relation to other fields is then pursued by discussing the involvement of terminology of science, aesthetic pattern, and human life. The results of this discussion give clear understanding how form related to deconstruction in architecture are used.

  8. Statistics of genome architecture

    International Nuclear Information System (INIS)

    The main statistical distributions applicable to the analysis of genome architecture and genome tracks are briefly discussed and critically assessed. Although the observed features in distributions of element lengths can be equally well fitted by the different statistical approximations, the interpretation of observed regularities may strongly depend on the chosen scheme. We discuss the possible evolution scenarios and describe the main characteristics obtained with different distributions. The expression for the assessment of levels in hierarchical chromatin folding is derived and the quantitative measure of genome architecture inhomogeneity is suggested. This theory provides the ground for the regular statistical study of genome architecture and genome tracks.

  9. The NOAA Satellite Observing System Architecture Study

    Science.gov (United States)

    Volz, Stephen; Maier, Mark; Di Pietro, David

    2016-01-01

    NOAA is beginning a study, the NOAA Satellite Observing System Architecture (NSOSA) study, to plan for the future operational environmental satellite system that will follow GOES and JPSS, beginning about 2030. This is an opportunity to design a modern architecture with no pre-conceived notions regarding instruments, platforms, orbits, etc. The NSOSA study will develop and evaluate architecture alternatives to include partner and commercial alternatives that are likely to become available. The objectives will include both functional needs and strategic characteristics (e.g., flexibility, responsiveness, sustainability). Part of this study is the Space Platform Requirements Working Group (SPRWG), which is being commissioned by NESDIS. The SPRWG is charged to assess new or existing user needs and to provide relative priorities for observational needs in the context of the future architecture. SPRWG results will serve as input to the process for new foundational (Level 0 and Level 1) requirements for the next generation of NOAA satellites that follow the GOES-R, JPSS, DSCOVR, Jason-3, and COSMIC-2 missions.

  10. Treatment of Bone Metastases with Radium-223 in Patients with Castration Resistant Prostate Cancer (CRPC): Alternative or Complementary to Innovative Molecular Therapies?

    International Nuclear Information System (INIS)

    The skeletal metastatic disease is a real clinical problem. Approximately 70% of patients with prostate or breast cancer and 35% of those with advanced lung, thyroid, and kidney cancers will develop skeletal metastases, which cause considerable morbidity. Several options are available for treatment, to be used either alone or in various combinations: hormones in case of hormone-sensitive tumours, chemotherapy, biphosphonates, external beam radiation therapy, surgery (in pathologic or impending fracture), bone-seeking radiopharmceuticals, and also molecular therapies. Focusing our attention to patients with prostate cancer, 50% of patients with bone metastases develop skeletal related events (SREs) such as: severe pain, pathologic fractures, spinal compression syndrome, malignant hypercalcemia, bone marrow suppression. All these SREs require adequate therapy since generally determine several functional impairments and worsen the prognosis. It is well known that skeletal complications reduce the quality of life affecting different aspects, physical, functional end emotional. SREs are associated also with lower survival

  11. 分子印迹在仿生免疫吸附分析中的应用%Molecularly Imprinted Polymers as Antibody Alternatives in Sorbent Immunoassays

    Institute of Scientific and Technical Information of China (English)

    吕春晖; 王硕; 方国臻; 汤轶伟; 王岁楼

    2012-01-01

    Molecularly imprinted polymer(MIP),a material which owns artificially-created binding sites coupled with several distinct advantages such as high chemical,mechanical and thermal stability,robust,easy preparation,low cost and reusable.MIP as mimic in pseudo-immunoassays have attracted considerable attention over the last few years.The advances in molecularly imprinted sorbent immunoassays(MIAs) are reviewed from radioligand immunoassays to non-radioligand immunoassays,and emphasize on the promotion which homogeneous immunoassay systems and new synthesis methods bring.It is shown that the perceived disadvantages of MIP can be ignored in MIAs.The existing problems and prospects of MIAs are also described.%分子印迹聚合物是一种含特异性识别位点的高分子材料,具有高稳定性、低成本、制备简单和可重复利用等特点,常被作为仿生抗体应用于免疫分析。本文综述了分子印迹免疫吸附分析(molecularlyimprinted sorbent immunoassays,MIAs)的研究进展,介绍了以不同标记物为探针的仿生免疫分析方法的发展,着重介绍了均相免疫分析系统与分子印迹聚合物的新型合成方法在MIAs中的应用。最后,本文指出分子印迹聚合物的一些缺点并没有阻碍其在免疫吸附分析中的应用,并对MIAs仍然存在的问题和发展前景进行了分析。

  12. Mixed Reality Architecture: a dynamic architectural topology

    OpenAIRE

    Schnädelbach, H.; A Penn; Steadman, P.

    2007-01-01

    Architecture can be shown to structure patterns of co-presence and in turn to be structured itself by the rules and norms of the society present within it. This two-way relationship exists in a surprisingly stable framework, as fundamental changes to buildings are slow and costly. At the same time, change within organisations is increasingly rapid and buildings are used to accommodate some of that change. This adaptation can be supported by the use of telecommunication technolo...

  13. Data Architecture for Sensor Network

    Directory of Open Access Journals (Sweden)

    Jan Ježek

    2012-03-01

    Full Text Available Fast development of hardware in recent years leads to the high availability of simple sensing devices at minimal cost. As a consequence, there is many of sensor networks nowadays. These networks can continuously produce a large amount of observed data including the location of measurement. Optimal data architecture for such propose is a challenging issue due to its large scale and spatio-temporal nature.  The aim of this paper is to describe data architecture that was used in a particular solution for storage of sensor data. This solution is based on relation data model – concretely PostgreSQL and PostGIS. We will mention out experience from real world projects focused on car monitoring and project targeted on agriculture sensor networks. We will also shortly demonstrate the possibilities of client side API and the potential of other open source libraries that can be used for cartographic visualization (e.g. GeoServer. The main objective is to describe the strength and weakness of usage of relation database system for such propose and to introduce also alternative approaches based on NoSQL concept.

  14. Robot Electronics Architecture

    Science.gov (United States)

    Garrett, Michael; Magnone, Lee; Aghazarian, Hrand; Baumgartner, Eric; Kennedy, Brett

    2008-01-01

    An electronics architecture has been developed to enable the rapid construction and testing of prototypes of robotic systems. This architecture is designed to be a research vehicle of great stability, reliability, and versatility. A system according to this architecture can easily be reconfigured (including expanded or contracted) to satisfy a variety of needs with respect to input, output, processing of data, sensing, actuation, and power. The architecture affords a variety of expandable input/output options that enable ready integration of instruments, actuators, sensors, and other devices as independent modular units. The separation of different electrical functions onto independent circuit boards facilitates the development of corresponding simple and modular software interfaces. As a result, both hardware and software can be made to expand or contract in modular fashion while expending a minimum of time and effort.

  15. DSP Architecture Design Essentials

    CERN Document Server

    Marković, Dejan

    2012-01-01

    In DSP Architecture Design Essentials, authors Dejan Marković and Robert W. Brodersen cover a key subject for the successful realization of DSP algorithms for communications, multimedia, and healthcare applications. The book addresses the need for DSP architecture design that maps advanced DSP algorithms to hardware in the most power- and area-efficient way. The key feature of this text is a design methodology based on a high-level design model that leads to hardware implementation with minimum power and area. The methodology includes algorithm-level considerations such as automated word-length reduction and intrinsic data properties that can be leveraged to reduce hardware complexity. From a high-level data-flow graph model, an architecture exploration methodology based on linear programming is used to create an array of architectural solutions tailored to the underlying hardware technology. The book is supplemented with online material: bibliography, design examples, CAD tutorials and custom software.

  16. Greek architecture now

    DEFF Research Database (Denmark)

    Skousbøll, Karin Merete

    2006-01-01

    With the author's Scandinavian viewpoint the aim of this book has been an investigation into contemporary Greek architecture and at the same time providing an understanding for its essential characteristics based on the historic, cultural heritage of Hellas....

  17. Analyzing architecture articles

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In the present study, we express the quality, function, and characteristics of architecture to help people comprehensively understand what architecture is. We also reveal the problems and conflict found in population, land, water resources, pollution, energy, and the organization systems in construction. China’s economy is transforming. We should focus on the cities, architectural environment, energy conservation, emission-reduction, and low-carbon output that will result in successful green development. We should macroscopically and microscopically analyze the development, from the natural environment to the artificial environment; from the relationship between human beings and nature to the combination of social ecology in cities, and farmlands. We must learn to develop and control them harmoniously and scientifically to provide a foundation for the methods used in architecture research.

  18. Architectural Competition and BIM

    DEFF Research Database (Denmark)

    Sørensen, Nils Lykke; Frandsen, Anne Kathrine; Øien, Turid Borgestrand

    2015-01-01

    on architecturalcompetitions, a series of interviews was conducted with building clients as well as architects, focusing on the impact of the above-mentioned changes within the building sector on architectural competitions as an institution. In the interviews, ICT and notleast BIM was a recurring...... clients, architects and client consultants) and the applied technologies (competition forms, ICT tools, directives) in architectural competitions in a theoretical actor-network perspective. The diverging understandings of the role of BIM are demonstrating one of many negotiations in progress in the...... network of architectural competitions. BIM is transformed from an inscription device visually representing the competition proposals to form an actant that challenges the very concept of architectural competition. The objective of the paper is to contribute to theunderstanding of BIM used in the kind of...

  19. Analysis of Architecture Pattern Usage in Legacy System Architecture Documentation

    NARCIS (Netherlands)

    Harrison, Neil B.; Avgeriou, Paris

    2008-01-01

    Architecture patterns are an important tool in architectural design. However, while many architecture patterns have been identified, there is little in-depth understanding of their actual use in software architectures. For instance, there is no overview of how many patterns are used per system or wh

  20. Redesigning architecture through photography

    OpenAIRE

    Germen, Murat

    2008-01-01

    Abstract – This paper focuses on the possibility of (re)designing architecture virtually with the help of one of the most important representation tools: Photography. Various digital processes like stitching multiple photos together and mirroring images in image editing software like Photoshop, allow this virtual architecture to take place in virtual environments. Photography can be utilized in the process of ‘constructing’ a new space --that we can call ‘narrative space’-- from an existing s...

  1. Essential software architecture

    CERN Document Server

    Gorton, Ian

    2011-01-01

    Job titles like ""Technical Architect"" and ""Chief Architect"" nowadays abound in software industry, yet many people suspect that ""architecture"" is one of the most overused and least understood terms in professional software development. Gorton's book tries to resolve this dilemma. It concisely describes the essential elements of knowledge and key skills required to be a software architect. The explanations encompass the essentials of architecture thinking, practices, and supporting technologies. They range from a general understanding of structure and quality attributes through technical i

  2. Generic Distributed Simulation Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Booker, C.P.

    1999-05-14

    A Generic Distributed Simulation Architecture is described that allows a simulation to be automatically distributed over a heterogeneous network of computers and executed with very little human direction. A prototype Framework is presented that implements the elements of the Architecture and demonstrates the feasibility of the concepts. It provides a basis for a future, improved Framework that will support legacy models. Because the Framework is implemented in Java, it may be installed on almost any modern computer system.

  3. Pushing architectural quality further

    OpenAIRE

    Laverge, Jelle; Van Den Bossche, Nathan; Janssens, Arnold

    2008-01-01

    In this paper, the intentions thriving the implementation of computational modeling of building physics as it is approached in the Architectural engineering courses at Ghent University are discussed. During the bachelor degree, courses focus mainly on integration of basic building physics feasibility in the architectural conceptualization. During the final bachelor year, students program their own simplified 2D models for internal condensation and thermal bridges in a spreadsheet, based on...

  4. Climate and architecture

    DEFF Research Database (Denmark)

    Tind Kristensen, Eva; Friis Møller, Winnie; Rotne, Georg;

    2010-01-01

    Climate and Architecture analyserer klimaets rolle i arkitekturen. Intentionen med bogen er at pege på nogle af de mange muligheder for bygningers klimaregulering, som et mere detaljeret studie af de lokale klimatiske forhold og den stedlige byggeskik tilbyder.......Climate and Architecture analyserer klimaets rolle i arkitekturen. Intentionen med bogen er at pege på nogle af de mange muligheder for bygningers klimaregulering, som et mere detaljeret studie af de lokale klimatiske forhold og den stedlige byggeskik tilbyder....

  5. Digitally-Driven Architecture

    OpenAIRE

    Henriette Bier; Terry Knight

    2014-01-01

    The shift from mechanical to digital forces architects to reposition themselves: Architects generate digital information, which can be used not only in designing and fabricating building components but also in embedding behaviours into buildings. This implies that, similar to the way that industrial design and fabrication with its concepts of standardisation and serial production influenced modernist architecture, digital design and fabrication influences contemporary architecture. While stan...

  6. Models of Architecture

    OpenAIRE

    Pelcat, Maxime; Desnos, Karol; Maggiani, Luca; Liu, Yanzhou; Heulot, Julien; Nezan, Jean-François; Bhattacharyya, Shuvra S.

    2015-01-01

    The current trend in high performance and embedded computing consists of designing increasingly complex heterogeneous hardware architectures with non-uniform communication resources. In order to take hardware and software design decisions, early evaluations of the system non-functional properties are needed. These evaluations of system efficiency require high-level information on both the algorithms and the architecture. In state of the art Model Driven Engineering (MDE) methods, different co...

  7. Aesthetics of sustainable architecture

    OpenAIRE

    Lee, S.

    2011-01-01

    The purpose of this book is to reveal, explore and further the debate on the aesthetic potentials of sustainable architecture and its practice. This book opens a new area of scholarship and discourse in the design and production of sustainable architecture, one that is based in aesthetics. The chapters in this book have been compiled from architects and scholars working in diverse research and practice areas in North America, Europe, the Middle East and Asia. While they approach the subject m...

  8. Artificial cognition architectures

    CERN Document Server

    Crowder, James A; Friess, Shelli A

    2013-01-01

    The goal of this book is to establish the foundation, principles, theory, and concepts that are the backbone of real, autonomous Artificial Intelligence. Presented here are some basic human intelligence concepts framed for Artificial Intelligence systems. These include concepts like Metacognition and Metamemory, along with architectural constructs for Artificial Intelligence versions of human brain functions like the prefrontal cortex. Also presented are possible hardware and software architectures that lend themselves to learning, reasoning, and self-evolution

  9. Self assembly of interlocked architectures

    International Nuclear Information System (INIS)

    An area of great interest is the synthesis and characterisation of molecules possessing moving parts, with the goal that they can act as 'molecular machine' carrying out tasks that molecules with fixed conventional architectures cannot do. Rotaxanes and catenanes (mechanically interlocked architectures) represent one approach toward achieving these aims as their component wheels and / or threads are connected together but can still move, in certain, controlled directions. This thesis focused on the study of structural rigidity and the preorganisation of thread binding sites as factors of major influence on template efficiency in the synthesis of hydrogen bond assembled supramolecular structures (rotaxanes and catenanes). Chapter One gives a brief outline of the common synthetic approaches to interlocked architectures (catenanes and rotaxanes) that are now being developed to address the problems outlined above. Chapter Two and Chapter Three concerns the synthesis of novel amide-based rotaxanes containing various saturated and unsaturated skeletons in their templating core. These new amide-based rotaxanes (muconic, hydromuconic and glutaconic) were synthesised by a clipping strategy in high yields. Chapter Four concerns the synthesis of a novel class of rotaxanes containing a naphthalene tetramide macrocycle that has a larger cavity (102). Several rotaxanation experiments based on macrocycle 102 precursors and threads containing several possible templating motifs were examined. Chapter Five report on the use of rotaxane wheels as a non-covalent protecting group able to influence the chemical behaviour of the functional groups in the central part of the axle. Chapter Six several heterocircuit [2]catenanes functionalised with various sulphide groups were synthesised and their monolayer forming capability on a gold surface studied. Another approach involving covalent attachment of macrocycles and catenanes on a pre-formed monolayer was also investigated. (author)

  10. ARCHITECTURE IN THE ISLAMIC CIVILIZATION: MUSLIM BUILDING OR ISLAMIC ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Ayat Ali Yassin

    2012-12-01

    Full Text Available The main problem of the theory in the arena of islamic architecture is affected by some of its Westernthoughts, and stereotyping the islamic architecture according to Western thoughts; this leads to the breakdownof the foundations in the islamic architecture. It is a myth that islamic architecture is subjected to theinfluence from foreign architectures. This paper will highlight the dialectical concept of islamic architecture ormuslim buildings and the areas of recognition in islamic architecture. It will also widen the knowledge in thecharacteristics of each point in time according to the stages of islamic architecture from the prophetic agemoving through the architecture outside the city of Medina, the Caliphs, the Umayyad, Abbasid, andarchitectural models by spatial and time periods, taking Iraq as the example to explain how the Islam influentson architecture and vice versa.

  11. From linear to cyclic oligoparaphenylenes: electronic and molecular changes traced in the vibrational Raman spectra and reformulation of the bond length alternation pattern.

    Science.gov (United States)

    Peña-Alvarez, Miriam; Qiu, Lili; Taravillo, Mercedes; Baonza, Valentín G; Delgado, M Carmen Ruiz; Yamago, Shigeru; Jasti, Ramesh; Navarrete, Juan T López; Casado, Juan; Kertesz, Miklos

    2016-04-28

    Cyclic paraphenylenes, [n]CPPs, and linear paraphenylenes, [n]LPPs, formed by n benzenes, are investigated by Raman spectroscopy for n = 5 to 12 and density functional theory (DFT) for n = 4 to 20. The information on the experimental Raman frequencies and intensities, combined with DFT computations and reported X-ray diffraction structures, provides a consistent interpretation of the Raman spectra and allows establishing relevant structure-property trends. Structural and electronic effects such as benzene ring bending, inter-ring torsions, π-conjugation (aromaticity) and orbital energy gaps as a function of the linear elongation in [n]LPPs versus the macrocyclic curvature in [n]CPPs and of the molecular size (i.e., polymer limit) are systematically analyzed on the basis of the vibrational Raman properties. Changes in the BLA as an indicator of the degree of quinonoid character are analyzed and linked to the Effective Conjugation Coordinate (ECC) model. The BLA patterns involved in twisted and non-twisted conformations and in different species (bipolarons, quinonoid tautomers, and ECC active modes) are compared and their differences are discussed. This paper offers a unified interpretation of structural and electronic aspects in relation to the evolution from linear 1D π-systems to cyclic 2D structures. PMID:26649442

  12. Molecular recognition of poly(A) by small ligands: an alternative method of analysis reveals nanomolar, cooperative and shape-selective binding

    Science.gov (United States)

    Çetinkol, Özgül Persil; Hud, Nicholas V.

    2009-01-01

    A few drug-like molecules have recently been found to bind poly(A) and induce a stable secondary structure (Tm ≈ 60°C), even though this RNA homopolymer is single-stranded in the absence of a ligand. Here, we report results from experiments specifically designed to explore the association of small molecules with poly(A). We demonstrate that coralyne, the first small molecule discovered to bind poly(dA), binds with unexpectedly high affinity (Ka >107 M−1), and that the crescent shape of coralyne appears necessary for poly(A) binding. We also show that the binding of similar ligands to poly(A) can be highly cooperative. For one particular ligand, at least six ligand molecules are required to stabilize the poly(A) self-structure at room temperature. This highly cooperative binding produces very sharp transitions between unstructured and structured poly(A) as a function of ligand concentration. Given the fact that junctions between Watson–Crick and A·A duplexes are tolerated, we propose that poly(A) sequence elements and appropriate ligands could be used to reversibly drive transitions in DNA and RNA-based molecular structures by simply diluting/concentrating a sample about the poly(A)-ligand ‘critical concentration’. The ligands described here may also find biological or medicinal applications, owing to the 3′-polyadenylation of mRNA in living cells. PMID:19073699

  13. The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review

    Science.gov (United States)

    Tsang, Ka-Kit; Kwong, Enid Wai-Yung; Woo, Kevin Y.; To, Tony Shing-Shun; Chung, Joanne Wai-Yee; Wong, Thomas Kwok-Shing

    2015-01-01

    Honey and silver have been used since ancient times for treating wounds. Their widespread clinical application has attracted attention in light of the increasing prevalence of antibiotic-resistant bacteria. While there have been a number of studies exploring the anti-inflammatory and antibacterial effects of manuka honey and nanocrystalline silver, their advantages and limitations with regard to the treatment of chronic wounds remain a subject of debate. The aim of this paper is to examine the evidence on the use of nanocrystalline silver and manuka honey for treating diabetic foot ulcers through a critical and comprehensive review of in vitro studies, animal studies, and in vivo studies. The findings from the in vitro and animal studies suggest that both agents have effective antibacterial actions. Their anti-inflammatory action and related impact on wound healing are unclear. Besides, there is no evidence to suggest that any topical agent is more effective for use in treating diabetic foot ulcer. Overall, high-quality, clinical human studies supported by findings from the molecular science on the use of manuka honey or nanocrystalline silver are lacking. There is a need for rigorously designed human clinical studies on the subject to fill this knowledge gap and guide clinical practice. PMID:26290672

  14. Utilizing the Central Courtyard of Traditional Architecture in Modern Architecture

    OpenAIRE

    Javad Samadi

    2014-01-01

    The purpose of this study is utilizing the central courtyard of traditional architecture in modern architecture. Since the nineteenth century, the traditional architecture has been more taken into account. From this time period, the sixties century is significantly important. The studies on the traditional architecture were conducted and followed in this period with the new objective and attitude. Until the early sixties century, most of the studies on the traditional architecture were briefl...

  15. Cosmic alternatives?

    Science.gov (United States)

    Gregory, Ruth

    2009-04-01

    "Cosmologists are often in error but never in doubt." This pithy characterization by the Soviet physicist Lev Landau sums up the raison d'être of Facts and Speculations in Cosmology. Authors Jayant Narlikar and Geoffrey Burbidge are proponents of a "steady state" theory of cosmology, and they argue that the cosmological community has become fixated on a "Big Bang" dogma, suppressing alternative viewpoints. This book very much does what it says on the tin: it sets out what is known in cosmology, and puts forward the authors' point of view on an alternative to the Big Bang.

  16. New Energy Architecture. Myanmar

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-15

    A global transition towards a new energy architecture is under way, driven by countries' need to respond to the changing dynamics of economic growth, environmental sustainability and energy security. The World Economic Forum, in collaboration with Accenture, has created the New Energy Architecture Initiative to address and accelerate this transition. The Initiative supports the development of national strategies and policy frameworks as countries seek to achieve the combined goals of energy security and access, sustainability, and economic growth and development. The World Economic Forum has formed a partnership with the Ministry of Energy of Myanmar to help apply the Initiative's approach to this developing and resource-rich nation. The Asian Development Bank and the World Economic Forum's Project Adviser, Accenture, have collaborated with the Forum on this consultation process, and have been supported by relevant government, industry and civil society stakeholders. The consultation process aims to understand the nation's current energy architecture challenges and provide an overview of a path to a New Energy Architecture through a series of insights. These insights could form the basis for a long-term multistakeholder roadmap to build Myanmar's energy sector in a way that is secure and sustainable, and promotes economic growth as the country makes its democratic transition. While not all recommendations can be implemented in the near term, they do provide options for creating a prioritized roadmap for Myanmar's energy transition. This report is the culmination of a nine-month multistakeholder process investigating Myanmar's energy architecture. Over the course of many visits to the country, the team has conducted numerous interviews, multistakeholder workshops, and learning and data-gathering exercises to ensure a comprehensive range of information and views. The team has also engaged with a variety of stakeholders to better

  17. Time · Space · Architecture

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In the 20th century a Swiss writer wrote a book titled Time, Space and Architecture, in which he discussed the relationship between architecture and the times. Fifty years after that, this paper adopts the same title, hoping to deepen the understanding of the space-time structure in architecture and contribute to the new exploration of architectural forms.

  18. System-Level Design Space Exploration of Reconfigurable Architectures

    OpenAIRE

    Sigdel, K.

    2011-01-01

    Reconfigurable architectures are becoming increasingly popular as they bear a promise of combining the flexibility of software with the performance of hardware. Nevertheless, such architectures are subject to numerous constraints, such as performance, memory requirements, chip area, and power consumption. To create an efficient design, performing Design Space Exploration (DSE) at various stages is essential in order to effectively appraise several design alternatives. DSE at early design stages...

  19. Openness and ‘closedness’ in Roman tomb architecture

    DEFF Research Database (Denmark)

    Petersen, Jane Hjarl

    2014-01-01

    This paper examines the early columbaria of the Laurentina necropolis in Ostia, in particular Tomb E1, in light of modern architectural theories concerning human responses to and use of architectural patterns, specifically the idea that patterns act as strong catalysts in generating a sense of gr...... of group membership within communities. The paper questions the longstanding classifications of these tombs as closed and isolated, and offers an alternative reading of their public as well as private existence....

  20. Incorporating Fault Tolerance Tactics in Software Architecture Patterns

    OpenAIRE

    Harrison, Neil B.; Avgeriou, Paris

    2008-01-01

    One important way that an architecture impacts fault tolerance is by making it easy or hard to implement measures that improve fault tolerance. Many such measures are described as fault tolerance tactics. We studied how various fault tolerance tactics can be implemented in the best-known architecture patterns. This shows that certain patterns are better suited to implementing fault tolerance tactics than others, and that certain alternate tactics are better matches than others for a given pat...

  1. The around architecture for dynamic location-based services

    OpenAIRE

    José, Rui; Moreira, Adriano; Rodrigues, Helena; Davies, Nigel

    2003-01-01

    This paper presents a generic concept of location-based service as an abstraction for supporting the association between computational resources and location. The objective is to extend the advantages of service-based architectures to the development of location-based systems, thus providing a more open and extensible alternative to the “vertical” approaches typically used in this type of system. The novel AROUND architecture is proposed as an approach for supporting location-based services ...

  2. Biomimetics - Architectural Considerations for Functional Nanocomposites

    OpenAIRE

    McKee, Jason R

    2015-01-01

    This thesis will focus on synthetic nanomaterials that combine hard nanocellulose reinforcement with soft molecularly engineered synthetic polymeric components. The architectural designs have all been inspired by natural nanocomposites, such as silk, animal bone and plant fibres. Typically, the design of natural structures are built around hard reinforcing nanodomains bound together by energy dissipating sacrificial networks. These natural materials consist of proteins, carbohydrates or britt...

  3. Data-Centric Enterprise Architecture

    Directory of Open Access Journals (Sweden)

    Zeinab Rajabi

    2012-08-01

    Full Text Available Enterprises choose Enterprise Architecture (EA solution, in order to overcome dynamic business challenges and in coordinate various enterprise elements. In this article, a solution is suggested for the Enterprise Architecture development. The solution focuses on architecture data in the Enterprise Architecture development process. Data-centric architecture approach is preferred product-centric architecture approach. We suggest using Enterprise Ontology (EO as context for collecting architecture data; Enterprise Ontology enhances quality of architecture data and lead to effective architecture results for decision-making. First, Enterprise is modeled using the ontology. Then how collecting Enterprise Architecture data based on the Enterprise Ontology is explained. Finally, the results and advantages of the solution are demonstrated.

  4. Growing Alternatives

    DEFF Research Database (Denmark)

    Bagger-Petersen, Mai Corlin

    2014-01-01

    From 2014, Anhui Province will pilot a reform of the residential land market in China, thus integrating rural Anhui in the national housing market. In contrast, artist and activist Ou Ning has proposed the Bishan time money currency, intending to establish an alternative economic circuit in Bishan...

  5. Educating ecological architecture – ecological educational architecture

    OpenAIRE

    Costa Santos, Sandra; Klein, Gerald; Despang, Martin

    2010-01-01

    “Sustainability,” being the buzzword of the 21st century, is particularly challenging to the current generation, now in their early teens, which grew up with a childhood of lackadaisical use of fossil energy. This generation, which will soon be leading the world, has been inappropriately labeled the “generation me” and is expected to prove its successful transitioning into “generation p[ostfossil].” If the young emerging architectural professionals choose, they can be the mission group in hel...

  6. Virtual architecture: reconstructing architecture through photography

    OpenAIRE

    Germen, Murat

    2007-01-01

    The concept of construction in architectural design process is a temporary action that exists for a while and transforms itself into another product; i.e. the final building to be inhabited. Construction site can be taken as a podium where a play-to-remain-incomplete is being staged. The incompleteness causes us to dream, due to the fact that a complete building loses its narrative potential as it informs us about all the necessary pieces that constitute the whole: There is no puzzle to solve...

  7. Solid-phase molecular recognition of cytosine based on proton-transfer reaction. Part II. supramolecular architecture in the cocrystals of cytosine and its 5-Fluoroderivative with 5-Nitrouracil

    OpenAIRE

    Portalone Gustavo

    2011-01-01

    Abstract Background Cytosine is a biologically important compound owing to its natural occurrence as a component of nucleic acids. Cytosine plays a crucial role in DNA/RNA base pairing, through several hydrogen-bonding patterns, and controls the essential features of life as it is involved in genetic codon of 17 amino acids. The molecular recognition among cytosines, and the molecular heterosynthons of molecular salts fabricated through proton-transfer reactions, might be used to investigate ...

  8. Perceived benefits from enterprise architecture

    OpenAIRE

    Plessius, Henk; Steenbergen, Marlies van; Slot, Raymond

    2014-01-01

    Enterprise Architecture has been developed in order to optimize the alignment between business needs and the (rapidly changing) possibilities of information technology. But do organizations indeed benefit from the application of Enterprise Architecture according to those who are in any way involved in architecture? To answer this question, a model has been developed (the Enterprise Architecture Value Framework) to organize the benefits of Enterprise Architecture. Based on this model, a survey...

  9. FASHION AND ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Hatice Harmankaya

    2014-04-01

    Full Text Available Fashion and architecture fields as non-verbal expression languages are affected by social, cultural, economic and historical factors and shaped around creativity. In both disciplines, based on human scales, employed material is brought dimension in the scope of math. Hue, texture, material, rate-ratio, line, form and shape are common design components of both fashion and architecture. Especially it is possible to see the accrued interactions in terms of pattern, form and decoration throughout the history. The aim of this survey is determining the common grounds, similarities, and interactions of clothing and architectural design that cover to protect the human body based on housing instinct. Descriptive method is used in the survey that examines the subject in depth. In the survey, that structural constitutions constructed on human body are studied in both fields in extent of art, status of fashion designers are affected from architecture is examined. New approaches are exhibited by giving examples of clothing designs in accordance with architectural principles.

  10. The Simulation Intranet Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, V.P.; Linebarger, J.M.; Miller, D.J.; Vandewart, R.L.

    1998-12-02

    The Simdarion Infranet (S1) is a term which is being used to dcscribc one element of a multidisciplinary distributed and distance computing initiative known as DisCom2 at Sandia National Laboratory (http ct al. 1998). The Simulation Intranet is an architecture for satisfying Sandia's long term goal of providing an end- to-end set of scrviccs for high fidelity full physics simu- lations in a high performance, distributed, and distance computing environment. The Intranet Architecture group was formed to apply current distributed object technologies to this problcm. For the hardware architec- tures and software models involved with the current simulation process, a CORBA-based architecture is best suited to meet Sandia's needs. This paper presents the initial desi-a and implementation of this Intranct based on a three-tier Network Computing Architecture(NCA). The major parts of the architecture include: the Web Cli- ent, the Business Objects, and Data Persistence.

  11. Software Architecture Design Reasoning

    Science.gov (United States)

    Tang, Antony; van Vliet, Hans

    Despite recent advancements in software architecture knowledge management and design rationale modeling, industrial practice is behind in adopting these methods. The lack of empirical proofs and the lack of a practical process that can be easily incorporated by practitioners are some of the hindrance for adoptions. In particular, the process to support systematic design reasoning is not available. To rectify this issue, we propose a design reasoning process to help architects cope with an architectural design environment where design concerns are cross-cutting and diversified.We use an industrial case study to validate that the design reasoning process can help improve the quality of software architecture design. The results have indicated that associating design concerns and identifying design options are important steps in design reasoning.

  12. Avionics System Architecture Tool

    Science.gov (United States)

    Chau, Savio; Hall, Ronald; Traylor, marcus; Whitfield, Adrian

    2005-01-01

    Avionics System Architecture Tool (ASAT) is a computer program intended for use during the avionics-system-architecture- design phase of the process of designing a spacecraft for a specific mission. ASAT enables simulation of the dynamics of the command-and-data-handling functions of the spacecraft avionics in the scenarios in which the spacecraft is expected to operate. ASAT is built upon I-Logix Statemate MAGNUM, providing a complement of dynamic system modeling tools, including a graphical user interface (GUI), modeling checking capabilities, and a simulation engine. ASAT augments this with a library of predefined avionics components and additional software to support building and analyzing avionics hardware architectures using these components.

  13. Persian architecture and mathematics

    CERN Document Server

    2012-01-01

    This volulme features eight original papers dedicated to the theme “Persian Architecture and Mathematics,” guest edited by Reza Sarhangi. All papers were approved through a rigorous process of blind peer review and edited by an interdisciplinary scientific editorial committee. Topics range from symmetry in ancient Persian architecture to the elaborate geometric patterns and complex three-dimensional structures of standing monuments of historical periods, from the expression of mathematical ideas to architectonic structures, and from decorative ornament to the representation of modern group theory and quasi-crystalline patterns. The articles discuss unique monuments Persia, including domed structures and two-dimensional patterns, which have received significant scholarly attention in recent years. This book is a unique contribution to studies of Persian architecture in relation to mathematics.

  14. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2006-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention......-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental Engineering, thus, in...... essence comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual disciplines...

  15. Architecture of Environmental Engineering

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Alting, Leo

    2004-01-01

    An architecture of Environmental Engineering has been developed comprising the various disciplines and tools involved. It identifies industry as the major actor and target group, and it builds on the concept of Eco-efficiency. To improve Eco-efficiency, there is a limited number of intervention...... of Eco-efficiency is the aim of Environmental Engineering, the discipline of synthesis – design and creation of solutions – will form a core pillar of the architecture. Other disciplines of Environmental Engineering exist forming the necessary background and frame for the synthesis. Environmental...... Engineering, thus, in essence comprise the disciplines of: management, system description & inventory, analysis & assessment, prioritisation, synthesis, and communication, each existing at all levels of intervention. The developed architecture of Environmental Engineering, thus, consists of thirty individual...

  16. Alternative 23

    OpenAIRE

    Jackson, Mark

    2014-01-01

    Alternative 23 is a curated exhibition of works by Steve Aylett, David Blandy & Daniel Locke, Let Me Feel Your Finger First, Laura Oldfield Ford, Plastique Fantastique and Henrik Schrat, including the first screening of Let Me Feel Your Finger First’s Postcolonial Capers. In 1985 DC Comics in the US had taken the commercial decision to unify the complex and contradictory character story arcs from its various strips such as Superman, Batman and Green Lantern. The resultant crossover series...

  17. Exploring Alternative Topologies for Network-on-Chip Architectures

    OpenAIRE

    Shafi Patel; Parag Parandkar; Sumant Katiyal; Ankit Agrawal

    2011-01-01

    With increase in integration density and complexity of the system-on-Chip (SOC), the conventional interconnects are not suitable to fulfill the demands. The application of traditional network technologies in the form of Network-on-Chip is a potential solution. NoC design space has many variables. Selection of a better topology results in lesser complexities and better power-efficiency. In the proposed work, key research area in Network-on-chip design targeting communication infrastructure spe...

  18. Towards an Architectural Anthropology

    DEFF Research Database (Denmark)

    Stender, Marie

    2016-01-01

    Architecture and anthropology have always had overlapping interests regarding issues such as spatial organisation, forms of human dwellings and the interplay between social life and physical surroundings. Recent developments in both disciplines make it even more relevant to explore and evolve their...... overlaps and collaboration. However, there are also challenging differences to take into account regarding disciplinary traditions of e.g. communication, temporality and normativity. This article explores the potentials and challenges of architectural anthropology as a distinct sub-discipline, and outlines...

  19. Synergetics and architecture

    Science.gov (United States)

    Maslov, V. P.; Maslova, T. V.

    2008-03-01

    A series of phenomena pertaining to economics, quantum physics, language, literary criticism, and especially architecture is studied from the standpoint of synergetics (the study of self-organizing complex systems). It turns out that a whole series of concrete formulas describing these phenomena is identical in these different situations. This is the case of formulas relating to the Bose-Einstein distribution of particles and the distribution of words from a frequency dictionary. This also allows to apply a "quantized" from of the Zipf law to the problem of the authorship of Quiet Flows the Don and to the "blending in" of new architectural structures in an existing environment.

  20. Reframing information architecture

    CERN Document Server

    Resmini, Andrea

    2014-01-01

    Information architecture has changed dramatically since the mid-1990s and earlier conceptions of the world and the internet being different and separate have given way to a much more complex scenario in the present day. In the post-digital world that we now inhabit the digital and the physical blend easily and our activities and usage of information takes place through multiple contexts and via multiple devices and unstable, emergent choreographies. Information architecture now is steadily growing into a channel- or medium-specific multi-disciplinary framework, with contributions coming from a

  1. Interactive Architecture #1

    OpenAIRE

    Oosterhuis, K.; X. Xia

    2007-01-01

    The iA bookzine series will consist of twelve issues, bi-annually published over a period of six years under the supervision of Prof. ir. Kas Oosterhuis, director of the Hperbody at the Delft University of Technology. Interactive Architecture - from here on abbreviated as iA - is NOT simply architecture that is responsive or adaptive to changing circumstances. On the contrary, iA is based on the concept of bi-directional communication, which requires two active parties. Naturally, communicati...

  2. Radio-Communications Architectures

    OpenAIRE

    Diet, Antoine; Villegas, Martine; Baudoin, Genevieve; Robert, Fabien

    2010-01-01

    The goal of this chapter is to demonstrate the absolute need of matching the architecture design and the signal carrying the information. In section 1 and 2, considerations about current users' needs helped to identify three types of carrier signals in the context of radio-communications: NB-CW, WB-CW and IR. A separation between CW and IR signals is unavoidable because it drives us to a different technological design. Basic blocks of transmitter architecture are optimized in function with th...

  3. Information architecture. Volume 3: Guidance

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The purpose of this document, as presented in Volume 1, The Foundations, is to assist the Department of Energy (DOE) in developing and promulgating information architecture guidance. This guidance is aimed at increasing the development of information architecture as a Departmentwide management best practice. This document describes departmental information architecture principles and minimum design characteristics for systems and infrastructures within the DOE Information Architecture Conceptual Model, and establishes a Departmentwide standards-based architecture program. The publication of this document fulfills the commitment to address guiding principles, promote standard architectural practices, and provide technical guidance. This document guides the transition from the baseline or defacto Departmental architecture through approved information management program plans and budgets to the future vision architecture. This document also represents another major step toward establishing a well-organized, logical foundation for the DOE information architecture.

  4. Biomedical laboratories: architecture and radioprotection principles

    International Nuclear Information System (INIS)

    In institutions where biological research are made and some technologies make use of radioisotope, the radiation protection is an issue of biosecurity for conceptual reasons. In the process of architectural design of Biomedical Laboratories, engineering and architecture reveal interfaces with other areas of knowledge and specific concepts. Exploring the role of architectural design in favor of personal and environmental protection in biological containment laboratories that handle non-sealed sources in research, the work discusses the triad that compose the principle of containment in health environments: best practices, protective equipment, physical facilities, with greater emphasis on the latter component. The shortcomings of the design process are reflected in construction and in use-operation and maintenance of these buildings, with direct consequences on the occupational health and safety, environmental and credibility of work processes. In this context, the importance of adoption of alternatives to improve the design process is confirmed, taking into account the early consideration of several variables involved and providing subsidies to the related laboratories . The research, conducted at FIOCRUZ - a Brazilian health institution, developed from the analysis of the participants in the architectural project, aiming at the formulation of design guidelines which could contribute to the rationalisation of this kind of building construction

  5. Discrete optimization in architecture architectural & urban layout

    CERN Document Server

    Zawidzki, Machi

    2016-01-01

    This book presents three projects that demonstrate the fundamental problems of architectural design and urban composition – the layout design, evaluation and optimization. Part I describes the functional layout design of a residential building, and an evaluation of the quality of a town square (plaza). The algorithm for the functional layout design is based on backtracking using a constraint satisfaction approach combined with coarse grid discretization. The algorithm for the town square evaluation is based on geometrical properties derived directly from its plan. Part II introduces a crowd-simulation application for the analysis of escape routes on floor plans, and optimization of a floor plan for smooth crowd flow. The algorithms presented employ agent-based modeling and cellular automata.

  6. Hadl: HUMS Architectural Description Language

    Science.gov (United States)

    Mukkamala, R.; Adavi, V.; Agarwal, N.; Gullapalli, S.; Kumar, P.; Sundaram, P.

    2004-01-01

    Specification of architectures is an important prerequisite for evaluation of architectures. With the increase m the growth of health usage and monitoring systems (HUMS) in commercial and military domains, the need far the design and evaluation of HUMS architectures has also been on the increase. In this paper, we describe HADL, HUMS Architectural Description Language, that we have designed for this purpose. In particular, we describe the features of the language, illustrate them with examples, and show how we use it in designing domain-specific HUMS architectures. A companion paper contains details on our design methodology of HUMS architectures.

  7. Architecture Descriptions. A Contribution to Modeling of Production System Architecture

    DEFF Research Database (Denmark)

    Jepsen, Allan Dam; Hvam, Lars

    operational design and handling of production system architecture, research is conducted into the description of production system architecture, including what an architecture description contains in general and what it should describe for production systems specifically. The contribution in this area of...... research consists of three parts. First, a conceptual model of architecture descriptions is established based on the ISO/IEC/IEEE 42010 standard. Secondly, the stakeholders and architecture related concerns of relevance for descriptions of production system architectures are investigated, and requirements......The subject of this PhD dissertation is architecture-centric design and the description of production system architecture. Companies are facing demands for the development and production of new products at an ever increasing rate, as the market life of products decreases and the rate at which...

  8. American School & University Architectural Portfolio 2000 Awards: Landscape Architecture.

    Science.gov (United States)

    American School & University, 2000

    2000-01-01

    Presents photographs and basic information on architectural design, costs, square footage, and principle designers of the award winning school landscaping projects that competed in the American School & University Architectural Portfolio 2000. (GR)

  9. Robustness via Diffractal Architectures

    CERN Document Server

    Moocarme, Matthew

    2015-01-01

    When plane waves diffract through fractal-patterned apertures, the resulting far-field profiles or diffractals also exhibit iterated, self-similar features. Here we show that this specific architecture enables robust signal processing and spatial multiplexing: arbitrary parts of a diffractal contain sufficient information to recreate the entire original sparse signal.

  10. Embedded instrumentation systems architecture

    Science.gov (United States)

    Visnevski, Nikita A.

    2007-04-01

    This paper describes the operational concept of the Embedded Instrumentation Systems Architecture (EISA) that is being developed for Test and Evaluation (T&E) applications. The architecture addresses such future T&E requirements as interoperability, flexibility, and non-intrusiveness. These are the ultimate requirements that support continuous T&E objectives. In this paper, we demonstrate that these objectives can be met by decoupling the Embedded Instrumentation (EI) system into an on-board and an off-board component. An on-board component is responsible for sampling, pre-processing, buffering, and transmitting data to the off-board component. The latter is responsible for aggregating, post-processing, and storing test data as well as providing access to the data via a clearly defined interface including such aspects as security, user authentication and access control. The power of the EISA architecture approach is in its inherent ability to support virtual instrumentation as well as enabling interoperability with such important T&E systems as Integrated Network-Enhanced Telemetry (iNET), Test and Training Enabling Architecture (TENA) and other relevant Department of Defense initiatives.

  11. Sun, space and architecture

    Energy Technology Data Exchange (ETDEWEB)

    Iyama, Takeshi

    1987-01-01

    Several projects being performed in Japan on the relationship between architectural space and solar energy are briefly described. The experimental buildings under investigation include the Matsumoto house, the Maruyama house, a tropical dome, the Teraoka Windhouse restaurant, a cross-cultural building blueprint, the Hirata town hall blueprint, the Kijo Alumni hall plan and the 'Ever-Spring' house.

  12. Architectural workshop Tyre3

    OpenAIRE

    Vasa J. Perović; Aljoša Dekleva; Anja Vidic

    2012-01-01

    The workshop deals with and researches three topics: space, user and material. The topics are developed in a parallel and mutually interrelated way, with the final intention being to undertake an architectural intervention on 1:1 scale within a specific public space for a specific user.

  13. Robotically Driven Architectural Production

    OpenAIRE

    Bier, H.H.

    2014-01-01

    Robotically driven architectural production advances seamless, computer-numerically controlled (CNC) and robotically supported design to production and operation processes enabling im-plementation of robotically driven buildings from conceptualisation to use. It enables production of free-formed, heterogeneous, optimized structures in order to address specific requirements in terms of properties (density, consistency, rigidity, etc.) and behaviours (re-configurability, responsiveness, etc.) i...

  14. Architecture Sauvage

    DEFF Research Database (Denmark)

    Baumeister, Ruth

    Danish artist Asger Jorn (1914-1973) is internationally renowed as a proponent of Nordic art and for his activities as a member of Cobra and the Situationist International. Quite apart from his art, Jorn produced a remarkable quantity of writing on art, architecture and urbanism and engaged in...

  15. Enterprise Architecture Evaluation

    DEFF Research Database (Denmark)

    Andersen, Peter; Carugati, Andrea

    2014-01-01

    By being holistically preoccupied with coherency among organizational elements such as organizational strategy, business needs and the IT functions role in supporting the business, enterprise architecture (EA) has grown to become a core competitive advantage. Though EA is a maturing research area...

  16. Future Network Architectures

    DEFF Research Database (Denmark)

    Wessing, Henrik; Bozorgebrahimi, Kurosh; Belter, Bartosz;

    2015-01-01

    This study identifies key requirements for NRENs towards future network architectures that become apparent as users become more mobile and have increased expectations in terms of availability of data. In addition, cost saving requirements call for federated use of, in particular, the optical...

  17. Drawing Music, Playing Architecture

    OpenAIRE

    Makrinos, George Adam

    2005-01-01

    ARCHITECTURE AND MUSIC SHARE INTRINSIC MEANINGS GENERATED BY A CONSTANT STREAM OF METAPHORS WHICH ARE FORMS OF POETIC TRANSFORMATIONS. This thesis sought to challange the present way an architect-musician makes drawings through the exploration of multimedia possibilities at hand. The drawings are composed using Macromedia Flash MX. OPEN HOMEPAGE.EXE To download flash player, click here: Download flash Player

  18. Architecture, constraints, and behavior

    OpenAIRE

    Doyle, John C.; Csete, Marie

    2011-01-01

    This paper aims to bridge progress in neuroscience involving sophisticated quantitative analysis of behavior, including the use of robust control, with other relevant conceptual and theoretical frameworks from systems engineering, systems biology, and mathematics. Familiar and accessible case studies are used to illustrate concepts of robustness, organization, and architecture (modularity and protocols) that are central to understanding complex networks. These essential organizational feature...

  19. Architecture and Energy

    DEFF Research Database (Denmark)

    Lauring, Michael; Marsh, Rob

    2009-01-01

    , and where the transition from an industrial to an information- or knowledge-based society is well-developed. The last three decades of the 20th century show many conscientious - both governmental and architectural - Danish attempts at creating buildings with lower heat consumption. The lower U...

  20. Architectural Creation of Light

    DEFF Research Database (Denmark)

    Bülow, Katja

    2015-01-01

    Bidraget "Architectural Creation of Light" indgår sammen med 108 andre bidrag i bogen "You Say Light, I Think Shadow". Bogens indhold undersøger: "Hvad er lys". I dette bidrag besvares spørgsmålet gennem iagttagelser af arkitektstuderendes undersøgelser af lyset i deres arbejdsmodeller i...

  1. Smart Grid Architectures

    DEFF Research Database (Denmark)

    Dondossola, Giovanna; Terruggia, Roberta; Bessler, Sandford;

    2014-01-01

    The scope of this paper is to address the evolution of distribution grid architectures following the widespread introduction of renewable energy sources. The increasing connection of distributed resources has a strong impact on the topology and the control functionality of the current distribution...

  2. Architecture of Institution & Home. Architecture as Cultural Medium

    OpenAIRE

    Robinson, J W

    2004-01-01

    This dissertation addresses how architecture functions as a cultural medium. It does so by by investigating how the architecture of institution and home each construct and support different cultural practices. By studying the design of ordinary settings in terms of how qualitative differences in architectural environments affect those who use them, this study exemplifies architectural research directed toward constructive cultural change. In the United States, ordinary people often describe h...

  3. Energy alternatives

    International Nuclear Information System (INIS)

    Due to sharp rise in oil proces after the 1973 Arab-Israeli War, world attention has been focussed on the energy problem. At present the energy problem is limited to the cost and reliability of supply, even though there are enough supplies to go round. However, in the future the problem will be of availability, because in spite of the full exploitation of currently available conventional energy sources, the supply will fall short of demand which will always be increasing. Hence, there is need to develop alternate energy sources, including fast breeder reactors, fusion reactors and MHD. Economic and technical aspects of these energy are discussed. (M.G.B.)

  4. Alternative detente

    International Nuclear Information System (INIS)

    The influence of the Chernobyl accident on the disarmament and anti-nuclear movements is discussed. The accident directed attention towards the areas in common rather than the areas of disagreement. It also demonstrated the environmental impact of radioactivity, strengthening the ecological case of the anti-nuclear movement. The issues are discussed for the Western and Eastern bloc countries and the relationship between the two. Sections focus on the Eco-protest, Green politics and economics and on the politics of minority protest and the Green alternative. (U.K.)

  5. Urban planning, architecture, landscape architecture projects underway for Roanoke

    OpenAIRE

    Chadwick, Heather Riley

    2009-01-01

    Faculty and students in the College of Architecture and Urban Studies at Virginia Tech bring expertise and solutions to communities all around the world. Currently, the college is working on six different urban planning, architecture, and landscape architecture projects in Roanoke, Va.

  6. ACOUSTICS IN ARCHITECTURAL DESIGN, AN ANNOTATED BIBLIOGRAPHY ON ARCHITECTURAL ACOUSTICS.

    Science.gov (United States)

    DOELLE, LESLIE L.

    THE PURPOSE OF THIS ANNOTATED BIBLIOGRAPHY ON ARCHITECTURAL ACOUSTICS WAS--(1) TO COMPILE A CLASSIFIED BIBLIOGRAPHY, INCLUDING MOST OF THOSE PUBLICATIONS ON ARCHITECTURAL ACOUSTICS, PUBLISHED IN ENGLISH, FRENCH, AND GERMAN WHICH CAN SUPPLY A USEFUL AND UP-TO-DATE SOURCE OF INFORMATION FOR THOSE ENCOUNTERING ANY ARCHITECTURAL-ACOUSTIC DESIGN…

  7. Enterprise architecture evaluation using architecture framework and UML stereotypes

    OpenAIRE

    Narges Shahi; Ali Haroun Abadi; Hadi abooei mehrizi

    2014-01-01

    There is an increasing need for enterprise architecture in numerous organizations with complicated systems with various processes. Support for information technology, organizational units whose elements maintain complex relationships increases. Enterprise architecture is so effective that its non-use in organizations is regarded as their institutional inability in efficient information technology management. The enterprise architecture process generally consists of three phases including stra...

  8. Alternative crops

    International Nuclear Information System (INIS)

    Surplus cereal production in the EEC and decreasing product prices, mainly for cereals, has prompted considerable interest for new earnings in arable farming. The objective was to examine whether suggested new crops (fibre, oil, medicinal and alternative grains crops) could be considered as real alternatives. Whether a specific crop can compete economically with cereals and whether there is a market demand for the crop is analyzed. The described possibilities will result in ca. 50,000 hectares of new crops. It is expected that they would not immediately provide increased earnings, but in the long run expected price developments are more positive than for cereals. The area for new crops will not solve the current surplus cereal problem as the area used for new crops is only 3% of that used for cereals. Preconditions for many new crops is further research activities and development work as well as the establishment of processing units and organizational initiatives. Presumably, it is stated, there will then be a basis for a profitable production of new crops for some farmers. (AB) (47 refs.)

  9. Plant architecture without multicellularity: quandaries over patterning and the soma-germline divide in siphonous algae

    Directory of Open Access Journals (Sweden)

    Viktoriya eConeva

    2015-04-01

    Full Text Available Multicellularity has independently evolved numerous times throughout the major lineages of life. Often, multicellularity can enable complex, macroscopic organismal architectures but it is not required for the elaboration of morphology. Several alternative cellular strategies have arisen as solutions permitting exquisite forms. The green algae class Ulvophyceae, for example, contains truly multicellular organisms, as well as macroscopic siphonous cells harboring one or multiple nuclei, and siphonocladous species, which are multinucleate and multicellular. These diverse cellular organizations raise a number of questions about the evolutionary and molecular mechanisms underlying complex organismal morphology in the green plants. Importantly, how does morphological patterning arise in giant coenocytes, and do nuclei, analogous to cells in multicellular organisms, take on distinct somatic and germline identities? Here, we comparatively explore examples of patterning and differentiation in diverse coenocytic and single-cell organisms and discuss possible mechanisms of development and nuclear differentiation in the siphonous algae.

  10. SPIM Architecture for MVC based Web Applications

    CERN Document Server

    Sridaran, R; Iyakutti, K; Mani, M N S

    2010-01-01

    The Model / View / Controller design pattern divides an application environment into three components to handle the user-interactions, computations and output respectively. This separation greatly favors architectural reusability. The pattern works well in the case of single-address space and not proven to be efficient for web applications involving multiple address spaces. Web applications force the designers to decide which of the components of the pattern are to be partitioned between the server and client(s) before the design phase commences. For any rapidly growing web application, it is very difficult to incorporate future changes in policies related to partitioning. One solution to this problem is to duplicate the Model and controller components at both server and client(s). However, this may add further problems like delayed data fetch, security and scalability issues. In order to overcome this, a new architecture SPIM has been proposed that deals with the partitioning problem in an alternative way. S...

  11. A Communication Architecture For IVHS

    OpenAIRE

    Streisand, Susan L.; Walrand, Jean

    1992-01-01

    This paper documents the development of a communications architecture for Intelligent Vehicle Highway Systems (IVHS) being studied by the California PATH Program. The authors use a layered architecture based on the OSI 7- layer reference model.

  12. An Experiment in Architectural Instruction.

    Science.gov (United States)

    Dvorak, Robert W.

    1978-01-01

    Discusses the application of the PLATO IV computer-based educational system to a one-semester basic drawing course for freshman architecture, landscape architecture, and interior design students and relates student reactions to the experience. (RAO)

  13. BIOLOGICAL NANOROBOT ARCHITECTURE FOR MEDICAL TARGET IDENTIFICATION

    Directory of Open Access Journals (Sweden)

    S. Paul and Dipti*

    2012-07-01

    Full Text Available This work has an innovative approach for the development of biological nanorobots with sensors for medicine. The biological nanorobots operate in a virtual environment based on random, thermal and chemical control techniques. The biological nanorobot architecture model has biological nano bioelectronics as the basis for manufacturing integrated system devices with embedded biological nano biosensors and actuators, which facilitates its application for medical target identification and drug delivery. The biological nanorobot interaction with the described workspace shows how these biological nanorobots detect the target area and supply the drug. Therefore, our work addresses the control and the architecture design for developing practical molecular machines. Advances in nanotechnology are enabling manufacturing nanosensors and actuators through nano bioelectronics and biologically inspired devices. Analysis of integrated system modeling is one important aspect for supporting nanotechnology in the fast development towards one of the most challenging new fields of science: molecular machines. The use of 3D simulation can provide interactive tools for addressing nanorobot choices on sensing, hardware architecture design, manufacturing approaches, and control methodology investigation.

  14. Economics-driven software architecture

    CERN Document Server

    Mistrik, Ivan; Kazman, Rick; Zhang, Yuanyuan

    2014-01-01

    Economics-driven Software Architecture presents a guide for engineers and architects who need to understand the economic impact of architecture design decisions: the long term and strategic viability, cost-effectiveness, and sustainability of applications and systems. Economics-driven software development can increase quality, productivity, and profitability, but comprehensive knowledge is needed to understand the architectural challenges involved in dealing with the development of large, architecturally challenging systems in an economic way. This book covers how to apply economic consider

  15. Controlling Material Reactivity Using Architecture.

    Science.gov (United States)

    Sullivan, Kyle T; Zhu, Cheng; Duoss, Eric B; Gash, Alexander E; Kolesky, David B; Kuntz, Joshua D; Lewis, Jennifer A; Spadaccini, Christopher M

    2016-03-01

    3D-printing methods are used to generate reactive material architectures. Several geometric parameters are observed to influence the resultant flame propagation velocity, indicating that the architecture can be utilized to control reactivity. Two different architectures, channels and hurdles, are generated, and thin films of thermite are deposited onto the surface. The architecture offers an additional route to control, at will, the energy release rate in reactive composite materials. PMID:26669517

  16. Compositional Specification of Software Architecture

    Science.gov (United States)

    Penix, John; Lau, Sonie (Technical Monitor)

    1998-01-01

    This paper describes our experience using parameterized algebraic specifications to model properties of software architectures. The goal is to model the decomposition of requirements independent of the style used to implement the architecture. We begin by providing an overview of the role of architecture specification in software development. We then describe how architecture specifications are build up from component and connector specifications and give an overview of insights gained from a case study used to validate the method.

  17. Enterprise architecture for business success

    CERN Document Server

    Wijegunaratne, Inji; Evans-Greenwood, Peter

    2014-01-01

    Enterprise Architecture (EA) has evolved to become a prominent presence in today's information systems and technology landscape. The EA discipline is rich in frameworks, methodologies, and the like. However, the question of 'value' for business ;professionals remains largely unanswered - that is, how best can Enterprise Architecture and Enterprise Architects deliver value to the enterprise? Enterprise Architecture for Business Success answers this question. Enterprise Architecture for Business Success is primarily intended for IT professionals working in the area of Enterprise Architectu

  18. Architectural Design Activities for JAS

    CERN Document Server

    Khaled, Lena

    2009-01-01

    The critical part for building any software system is its architecture. Architectural design is a design at a higher level of abstraction. A good architecture ensures that software will satisfy its requirement. This paper defines the most important activities of architectural design that used through building any software; also it applies these activities on one type of Electronic Commerce (EC) applications that is Job Agency System(JAS) to show how these activities can work through these types of applications.

  19. Software, architecture, and participatory design

    OpenAIRE

    Rank, Stephen; O'Coill, Carl; Boldyreff, Cornelia; Doughty, Mark

    2004-01-01

    Much work in software architecture has been inspired by work in physical architecture, in particular Alexander's work on `design patterns'. By contrast, Alexander's work is little-used in town planning and architecture. In this paper, we examine some of the reasons that this is so, describe some parallels and differences between the fields of physical and software architecture, and identify areas in which future collaboration may be fruitful. The notion of `participatory design' is important ...

  20. On the origin of the functional architecture of the cortex.

    Directory of Open Access Journals (Sweden)

    Dario L Ringach

    Full Text Available The basic structure of receptive fields and functional maps in primary visual cortex is established without exposure to normal sensory experience and before the onset of the critical period. How the brain wires these circuits in the early stages of development remains unknown. Possible explanations include activity-dependent mechanisms driven by spontaneous activity in the retina and thalamus, and molecular guidance orchestrating thalamo-cortical connections on a fine spatial scale. Here I propose an alternative hypothesis: the blueprint for receptive fields, feature maps, and their inter-relationships may reside in the layout of the retinal ganglion cell mosaics along with a simple statistical connectivity scheme dictating the wiring between thalamus and cortex. The model is shown to account for a number of experimental findings, including the relationship between retinotopy, orientation maps, spatial frequency maps and cytochrome oxidase patches. The theory's simplicity, explanatory and predictive power makes it a serious candidate for the origin of the functional architecture of primary visual cortex.

  1. Model-driven migration of supervisory machine control architectures

    OpenAIRE

    de Graaf B; Weber S.; van Deursen A.

    2008-01-01

    Supervisory machine control is the high-level control in advanced manufacturing machines that is responsible for the coordination of manufacturing activities. Traditionally, the design of such control systems is based on finite state machines. An alternative, more flexible approach is based on task-resource models. This paper describes an approach for the migration of supervisory machine control architectures towards this alternative approach. We propose a generic migration approach based on ...

  2. Architecture for autonomy

    Science.gov (United States)

    Broten, Gregory S.; Monckton, Simon P.; Collier, Jack; Giesbrecht, Jared

    2006-05-01

    In 2002 Defence R&D Canada changed research direction from pure tele-operated land vehicles to general autonomy for land, air, and sea craft. The unique constraints of the military environment coupled with the complexity of autonomous systems drove DRDC to carefully plan a research and development infrastructure that would provide state of the art tools without restricting research scope. DRDC's long term objectives for its autonomy program address disparate unmanned ground vehicle (UGV), unattended ground sensor (UGS), air (UAV), and subsea and surface (UUV and USV) vehicles operating together with minimal human oversight. Individually, these systems will range in complexity from simple reconnaissance mini-UAVs streaming video to sophisticated autonomous combat UGVs exploiting embedded and remote sensing. Together, these systems can provide low risk, long endurance, battlefield services assuming they can communicate and cooperate with manned and unmanned systems. A key enabling technology for this new research is a software architecture capable of meeting both DRDC's current and future requirements. DRDC built upon recent advances in the computing science field while developing its software architecture know as the Architecture for Autonomy (AFA). Although a well established practice in computing science, frameworks have only recently entered common use by unmanned vehicles. For industry and government, the complexity, cost, and time to re-implement stable systems often exceeds the perceived benefits of adopting a modern software infrastructure. Thus, most persevere with legacy software, adapting and modifying software when and wherever possible or necessary -- adopting strategic software frameworks only when no justifiable legacy exists. Conversely, academic programs with short one or two year projects frequently exploit strategic software frameworks but with little enduring impact. The open-source movement radically changes this picture. Academic frameworks

  3. Architectural engineering of FRP bridges

    OpenAIRE

    Smits, J.E.P.

    2014-01-01

    This paper deals with the use of Fibre Reinforced Polymers (FRP's) in architectural and structural bridge design. The challenges and opportunities that come with this relatively new material are discussed. An inventory is made of recent engineers' solutions in FRP, followed by a discussion on architectural application of FRP's derived from the authors architectural practice.

  4. Communication of IT-Architecture

    NARCIS (Netherlands)

    Koning, H.

    2008-01-01

    This PhD thesis contains the results of various research activities that fall under the topic ‘communication of IT-architecture’. The term IT-architecture defines the various types of architecture that can be found in the domain of Information Technology (software architecture, enterprise architectu

  5. Meet French Architecture in China

    Institute of Scientific and Technical Information of China (English)

    Susan

    2005-01-01

    On April 5, a French architectural exhibition entitled ""French Visions: City, Architecture and Sustainable Development"" was unveiled in Beijing Urban Planning Center. As a key exhibition within the framework of French Year in China, the exhibition will also be displayed in Shanghai and Chongqing. The largest exhibition of its kind ever held in China, French Visions extensively showed accomplishments of contemporary French architectural design.

  6. Molecular mechanisms of alternative estrogen receptor signaling

    OpenAIRE

    Björnström, Linda

    2003-01-01

    Estrogen is a key regulator of growth, differentiation and function in a broad range of target tissues, including the male and female reproductive tracts, mammary gland, bone, brain and the cardiovascular system. The biological effects of estrogen are mediated through estrogen receptor a (ERalpha) and estrogen receptor beta (ERbeta), which belong to a large superfamily of nuclear receptors that act as ligand-activated transcription factors. The classical mechanism of ER acti...

  7. Energy alternatives

    International Nuclear Information System (INIS)

    English. A special committe of the Canadian House of Commons was established on 23 May 1980 to investigate the use of alternative energy sources such as 'gasohol', liquified coal, solar energy, methanol, wind and tidal power, biomass, and propane. In its final report, the committee envisions an energy system for Canada based on hydrogen and electricity, using solar and geothermal energy for low-grade heat. The committe was not able to say which method of generating electricty would dominate in the next century, although it recommends that fossil fuels should not be used. The fission process is not specifically discussed, but the outlook for fusion was investigated, and continued governmental support of fusion research is recommended. The report proposes some improvements in governmental energy organizations and programs

  8. Architecture in metamorphosis

    Directory of Open Access Journals (Sweden)

    Tomas Ghisellini

    2015-11-01

    Full Text Available In this “dromocractic” era, dominated by the absolute values of speed and short duration of each phenomenon, architecture is called to the paradoxical challenge of precariousness, which is actually transient and fleeting. In a delicate combinational process between freedom and construction, lightness and gravity, the tool for contemporary urban design, can only be that which governs the near future of our cities. The process of exchange between architecture and design has to deal primarily with the multidisciplinary character that has been influencing creative professions which have increasingly more in common with one another. The figure of the designer has taken on characters, skills and roles that were unthinkable until recently times. Failing to understand this transformation will condemn the designer as irrelevant.

  9. Performative Urban Architecture

    DEFF Research Database (Denmark)

    Thomsen, Bo Stjerne; Jensen, Ole B.

    The paper explores how performative urban architecture can enhance community-making and public domain using socio-technical systems and digital technologies to constitute an urban reality. Digital medias developed for the web are now increasingly occupying the urban realm as a tool for navigating...... discusses the perspectives of using interactive technologies for performative objects, which are able to register the impulses of urban activity and reproduce the contexts of the city. In this way the performative environment is established as an event setting providing an embodied experience as a ‘quasi......-object' that can couple relationships between architecture, humans and society. These performative relationships between digital and physical environments are seen as illustrative of the social production of space by performance and the creative production of identity. The paper reflects on the perspectives of...

  10. Generic robot architecture

    Science.gov (United States)

    Bruemmer, David J [Idaho Falls, ID; Few, Douglas A [Idaho Falls, ID

    2010-09-21

    The present invention provides methods, computer readable media, and apparatuses for a generic robot architecture providing a framework that is easily portable to a variety of robot platforms and is configured to provide hardware abstractions, abstractions for generic robot attributes, environment abstractions, and robot behaviors. The generic robot architecture includes a hardware abstraction level and a robot abstraction level. The hardware abstraction level is configured for developing hardware abstractions that define, monitor, and control hardware modules available on a robot platform. The robot abstraction level is configured for defining robot attributes and provides a software framework for building robot behaviors from the robot attributes. Each of the robot attributes includes hardware information from at least one hardware abstraction. In addition, each robot attribute is configured to substantially isolate the robot behaviors from the at least one hardware abstraction.

  11. Heterogeneous network architectures

    DEFF Research Database (Denmark)

    Christiansen, Henrik Lehrmann

    2006-01-01

    Future networks will be heterogeneous! Due to the sheer size of networks (e.g., the Internet) upgrades cannot be instantaneous and thus heterogeneity appears. This means that instead of trying to find the olution, networks hould be designed as being heterogeneous. One of the key equirements here...... is flexibility. This thesis investigates such heterogeneous network architectures and how to make them flexible. A survey of algorithms for network design is presented, and it is described how using heuristics can increase the speed. A hierarchical, MPLS based network architecture is described...... and it is discussed that it is advantageous to heterogeneous networks and illustrated by a number of examples. Modeling and simulation is a well-known way of doing performance evaluation. An approach to event-driven simulation of communication networks is presented and mixed complexity modeling, which can simplify...

  12. Consistent model driven architecture

    Science.gov (United States)

    Niepostyn, Stanisław J.

    2015-09-01

    The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.

  13. Architecture and communication

    Directory of Open Access Journals (Sweden)

    Špela Hudnik

    2003-01-01

    Full Text Available The article presents effects of technology, science and capital strategies on changes in traditional forms and definitions of space, architecture and bodies. It confronts us with new processes of thinking and living that are constantly being transformed into new dynamic time and spatial contexts. Space is becoming the information filter, communication network. A cross-section of three landscapes: landscape of megastructures, nomadic landscapes and psychedelic landscapes, theory contributes to understanding of media and space-age technology, information technology and electronical language. It offers designs of various megastructures, media surfaces and envelopes of contemporary information society: the anthropological module, hyper- and infra-bodies, bio-electronical bodies and population genetics bodies. It presents the architecture of communication.

  14. Dance Architecture Spatiality

    OpenAIRE

    Renard, Johanna

    2014-01-01

    L’ouvrage rassemble les traces visuelles et textuelles du programme intensif européen DAS (Dance Architecture Spatiality), coordonné par Frédérique Villemur, qui s’est déroulé en 2012 à Athènes, sur les collines face à l’Acropole. Guidés par Patrice Barthès, chorégraphe en résidence à l’ENSAM de Montpellier, une vingtaine d’étudiants en architecture, esthétique et design ont explorés les interactions entre le geste dansé et les temporalités architecturales et paysagères. Accueilli par l’Isado...

  15. Algorithms versus architectures for computational chemistry

    Science.gov (United States)

    Partridge, H.; Bauschlicher, C. W., Jr.

    1986-01-01

    The algorithms employed are computationally intensive and, as a result, increased performance (both algorithmic and architectural) is required to improve accuracy and to treat larger molecular systems. Several benchmark quantum chemistry codes are examined on a variety of architectures. While these codes are only a small portion of a typical quantum chemistry library, they illustrate many of the computationally intensive kernels and data manipulation requirements of some applications. Furthermore, understanding the performance of the existing algorithm on present and proposed supercomputers serves as a guide for future programs and algorithm development. The algorithms investigated are: (1) a sparse symmetric matrix vector product; (2) a four index integral transformation; and (3) the calculation of diatomic two electron Slater integrals. The vectorization strategies are examined for these algorithms for both the Cyber 205 and Cray XMP. In addition, multiprocessor implementations of the algorithms are looked at on the Cray XMP and on the MIT static data flow machine proposed by DENNIS.

  16. Architecture and communication

    OpenAIRE

    Špela Hudnik

    2003-01-01

    The article presents effects of technology, science and capital strategies on changes in traditional forms and definitions of space, architecture and bodies. It confronts us with new processes of thinking and living that are constantly being transformed into new dynamic time and spatial contexts. Space is becoming the information filter, communication network. A cross-section of three landscapes: landscape of megastructures, nomadic landscapes and psychedelic landscapes, theory contributes to...

  17. An Embodied Architecture

    OpenAIRE

    Frances Downing; Upali Nanda; Narongpon Laiprakobsup; Shima B. Mohajeri

    2012-01-01

    An architecture of the body is emerging out of theories of biology, complexity, and systems through the use of an evolving organism as its metaphor. Autopoiesis is the term used by biologists to describe the realm of existence for a living organism as it slides between the interchange of structure and information. Incoming information is filtered through the organism for its usefulness in the art of staying alive. Structural or organizational changes evolve as the organism adjusts to new info...

  18. Avionics Architecture Modelling Language

    Science.gov (United States)

    Alana, Elena; Naranjo, Hector; Valencia, Raul; Medina, Alberto; Honvault, Christophe; Rugina, Ana; Panunzia, Marco; Dellandrea, Brice; Garcia, Gerald

    2014-08-01

    This paper presents the ESA AAML (Avionics Architecture Modelling Language) study, which aimed at advancing the avionics engineering practices towards a model-based approach by (i) identifying and prioritising the avionics-relevant analyses, (ii) specifying the modelling language features necessary to support the identified analyses, and (iii) recommending/prototyping software tooling to demonstrate the automation of the selected analyses based on a modelling language and compliant with the defined specification.

  19. Conservation of Architectural Heritage

    OpenAIRE

    Quintero, mario Santana; Blake, Bill; Eppich, Rand

    2007-01-01

    Currently, a wide range of digital sensors for capturing our architectural heritage are available. They offer the opportunity to acquire large sets of information in a relatively short time. These sensors include digital photography (photogrammetry-scaled rectified photography), total stations, laser scanners, high-resolution panoramic devices, etc. A lot of effort has been put in the application of these tools in the field of conservation, however a significant gap exists between the informa...

  20. Information systems definition architecture

    Energy Technology Data Exchange (ETDEWEB)

    Calapristi, A.J.

    1996-06-20

    The Tank Waste Remediation System (TWRS) Information Systems Definition architecture evaluated information Management (IM) processes in several key organizations. The intent of the study is to identify improvements in TWRS IM processes that will enable better support to the TWRS mission, and accommodate changes in TWRS business environment. The ultimate goals of the study are to reduce IM costs, Manage the configuration of TWRS IM elements, and improve IM-related process performance.

  1. Aerobot Autonomy Architecture

    Science.gov (United States)

    Elfes, Alberto; Hall, Jeffery L.; Kulczycki, Eric A.; Cameron, Jonathan M.; Morfopoulos, Arin C.; Clouse, Daniel S.; Montgomery, James F.; Ansar, Adnan I.; Machuzak, Richard J.

    2009-01-01

    An architecture for autonomous operation of an aerobot (i.e., a robotic blimp) to be used in scientific exploration of planets and moons in the Solar system with an atmosphere (such as Titan and Venus) is undergoing development. This architecture is also applicable to autonomous airships that could be flown in the terrestrial atmosphere for scientific exploration, military reconnaissance and surveillance, and as radio-communication relay stations in disaster areas. The architecture was conceived to satisfy requirements to perform the following functions: a) Vehicle safing, that is, ensuring the integrity of the aerobot during its entire mission, including during extended communication blackouts. b) Accurate and robust autonomous flight control during operation in diverse modes, including launch, deployment of scientific instruments, long traverses, hovering or station-keeping, and maneuvers for touch-and-go surface sampling. c) Mapping and self-localization in the absence of a global positioning system. d) Advanced recognition of hazards and targets in conjunction with tracking of, and visual servoing toward, targets, all to enable the aerobot to detect and avoid atmospheric and topographic hazards and to identify, home in on, and hover over predefined terrain features or other targets of scientific interest. The architecture is an integrated combination of systems for accurate and robust vehicle and flight trajectory control; estimation of the state of the aerobot; perception-based detection and avoidance of hazards; monitoring of the integrity and functionality ("health") of the aerobot; reflexive safing actions; multi-modal localization and mapping; autonomous planning and execution of scientific observations; and long-range planning and monitoring of the mission of the aerobot. The prototype JPL aerobot (see figure) has been tested extensively in various areas in the California Mojave desert.

  2. From science to architecture

    OpenAIRE

    Coleman, Honor

    2014-01-01

    non-peer-reviewed My thesis began with an interest in finding various differences and commonalities in the fields of science and architecture. I have always been interested by the seemingly fast paced progression of science and technology in comparison to other creative fields. There appears to be a constant stream of discoveries and new technologies. And so I wondered if there was anything about the way the scientist works that the architect could learn. I began by reading books abo...

  3. Attacks on Emerging Architectures

    OpenAIRE

    Hanna, Steven Craig

    2012-01-01

    New architectures require careful examination of security properties in order to assess and contain new threats. In light of this, emerging technologies, such as web APIs, medical devices, and applications on mobile phones, are a new security landscape that has recurring security problems. We develop new techniques to analyze these applications for security vulnerabilities, utilizing techniques including: dynamic symbolic execution, binary analysis and reverse engineering, and wide scale appl...

  4. A Natural Language Architecture

    OpenAIRE

    Sodiya, Adesina Simon

    2007-01-01

    Natural languages are the latest generation of programming languages, which require processing real human natural expressions. Over the years, several groups or researchers have trying to develop widely accepted natural language languages based on artificial intelligence (AI). But no true natural language has been developed. The goal of this work is to design a natural language preprocessing architecture that identifies and accepts programming instructions or sentences in their natural forms ...

  5. Software Architecture in Depth

    OpenAIRE

    Lars Heinemann; Christian Neumann; Birgit Penzenstadler; Wassiou Sitou

    2016-01-01

    The quality of software architecture is one of the crucial success factors for the development of large and/or complex systems. Therefore, a good software architect plays a key role in every demanding project: She or he has the overview of the overall system and sets the framework for the implementation. In order to be successful in this task, software architects need well-founded and encompassing knowledge about design, which exceeds pure programming and specific spe- cialization a...

  6. Enterprise Architecture Evaluation Components

    OpenAIRE

    Niemi, Eetu; Ylimäki, Tanja

    2008-01-01

    Enterprise Architecture (EA) is a holistic view of an organization, including the viewpoints of business, information, systems and technology. It is stated to provide significant benefits to organizations, and is therefore of interest for both academics and practitioners. However, evaluating EA, or its benefits, is difficult. Moreover, the studies on EA evaluation are mostly inconsistent, and almost omit the planning aspect of evaluation. This study suggests the evaluation components that nee...

  7. Sustainable Enterprise Architecture

    CERN Document Server

    Hausman, Kirk

    2011-01-01

    Providing guidance that can be applied to an enterprise of any scale, this book supplies IT practitioners with the tools needed to present enterprise architecture concepts to non-technical stakeholders. Rather than focusing on a single governance framework, the text explains how to develop successful and sustainable enterprise deployments in any setting. Coverage includes general security practices, common threats, storage mechanisms, and the impact of virtualization. The author presents functional considerations for developing and maintaining extended enterprise networks using practices teste

  8. Future database machine architectures

    OpenAIRE

    Hsiao, David K.

    1984-01-01

    There are many software database management systems available on many general-purpose computers ranging from micros to super-mainframes. Database machines as backened computers can offload the database management work from the mainframe so that we can retain the same mainframe longer. However, the database backend must also demonstrate lower cost, higher performance, and newer functionality. Some of the fundamental architecture issues in the design of high-performance and great-capacity datab...

  9. GRC3_ALIVE ARCHITECTURE

    OpenAIRE

    Pferdmenges, Petra

    2011-01-01

    The search for the clean and the perfect in our cities is reflected in the spatial exclusion of certain people, especially those on the margin of society. New immigrants, prostitutes and voyageurs are part of those communities often placed in invaluable districts. The concept of the city with a rich diversity of cultures and social backgrounds becomes increasingly a fairy tale, far from reality.As curator of the 4th International Architecture Biennale in Rotterdam (2010) Kees Christiaanse rev...

  10. Adapted Verbal Feedback, Instructor Interaction and Student Emotions in the Landscape Architecture Studio

    Science.gov (United States)

    Smith, Carl A.; Boyer, Mark E.

    2015-01-01

    In light of concerns with architectural students' emotional jeopardy during traditional desk and final-jury critiques, the authors pursue alternative approaches intended to provide more supportive and mentoring verbal assessment in landscape architecture studios. In addition to traditional studio-based critiques throughout a semester, we provide…

  11. HIGH SPEED POINT ARITHMETIC ARCHITECTURE FOR ECC ON FPGA

    Directory of Open Access Journals (Sweden)

    Rahila Bilal,

    2010-09-01

    Full Text Available Elliptic curve cryptography plays a crucial role in networking and communication security. ECC have evolved in the recent past as an important alternative to established systems like RSA. This paper describes the implementation of an elliptic curve coprocessor based on the FPGA , which can provide a significant speedup for these cryptosystems. The FPGA configuration file is synthesized from VHDL code applying different hardware synthesis products. The implementation of ECC lies in three levels: scalar multiplication, point addition/doubling and finite field modular arithmetic. In this paper, we present a novel fast architecture for the point addition/doubling level in the projective coordinate. The proposed Architecture is based on Binary Field. The Design performs multiplication using Polynomial Basis. Analysis shows that, with reasonable hardware overhead, our architecture can achieve a high speedup for the point addition operation and point Doubling operation.Furthermore, the architecture is parameterized for different data widths to evaluate the optimal resource utilization.

  12. Quantifying loopy network architectures.

    Directory of Open Access Journals (Sweden)

    Eleni Katifori

    Full Text Available Biology presents many examples of planar distribution and structural networks having dense sets of closed loops. An archetype of this form of network organization is the vasculature of dicotyledonous leaves, which showcases a hierarchically-nested architecture containing closed loops at many different levels. Although a number of approaches have been proposed to measure aspects of the structure of such networks, a robust metric to quantify their hierarchical organization is still lacking. We present an algorithmic framework, the hierarchical loop decomposition, that allows mapping loopy networks to binary trees, preserving in the connectivity of the trees the architecture of the original graph. We apply this framework to investigate computer generated graphs, such as artificial models and optimal distribution networks, as well as natural graphs extracted from digitized images of dicotyledonous leaves and vasculature of rat cerebral neocortex. We calculate various metrics based on the asymmetry, the cumulative size distribution and the Strahler bifurcation ratios of the corresponding trees and discuss the relationship of these quantities to the architectural organization of the original graphs. This algorithmic framework decouples the geometric information (exact location of edges and nodes from the metric topology (connectivity and edge weight and it ultimately allows us to perform a quantitative statistical comparison between predictions of theoretical models and naturally occurring loopy graphs.

  13. Paneling architectural freeform surfaces

    KAUST Repository

    Eigensatz, Michael

    2010-07-26

    The emergence of large-scale freeform shapes in architecture poses big challenges to the fabrication of such structures. A key problem is the approximation of the design surface by a union of patches, socalled panels, that can be manufactured with a selected technology at reasonable cost, while meeting the design intent and achieving the desired aesthetic quality of panel layout and surface smoothness. The production of curved panels is mostly based on molds. Since the cost of mold fabrication often dominates the panel cost, there is strong incentive to use the same mold for multiple panels. We cast the major practical requirements for architectural surface paneling, including mold reuse, into a global optimization framework that interleaves discrete and continuous optimization steps to minimize production cost while meeting user-specified quality constraints. The search space for optimization is mainly generated through controlled deviation from the design surface and tolerances on positional and normal continuity between neighboring panels. A novel 6-dimensional metric space allows us to quickly compute approximate inter-panel distances, which dramatically improves the performance of the optimization and enables the handling of complex arrangements with thousands of panels. The practical relevance of our system is demonstrated by paneling solutions for real, cutting-edge architectural freeform design projects. © 2010 ACM.

  14. ARCOMEM Crawling Architecture

    Directory of Open Access Journals (Sweden)

    Vassilis Plachouras

    2014-08-01

    Full Text Available The World Wide Web is the largest information repository available today. However, this information is very volatile and Web archiving is essential to preserve it for the future. Existing approaches to Web archiving are based on simple definitions of the scope of Web pages to crawl and are limited to basic interactions with Web servers. The aim of the ARCOMEM project is to overcome these limitations and to provide flexible, adaptive and intelligent content acquisition, relying on social media to create topical Web archives. In this article, we focus on ARCOMEM’s crawling architecture. We introduce the overall architecture and we describe its modules, such as the online analysis module, which computes a priority for the Web pages to be crawled, and the Application-Aware Helper which takes into account the type of Web sites and applications to extract structure from crawled content. We also describe a large-scale distributed crawler that has been developed, as well as the modifications we have implemented to adapt Heritrix, an open source crawler, to the needs of the project. Our experimental results from real crawls show that ARCOMEM’s crawling architecture is effective in acquiring focused information about a topic and leveraging the information from social media.

  15. Paneling architectural freeform surfaces

    KAUST Repository

    Eigensatz, Michael

    2010-07-25

    The emergence of large-scale freeform shapes in architecture poses big challenges to the fabrication of such structures. A key problem is the approximation of the design surface by a union of patches, so-called panels, that can be manufactured with a selected technology at reasonable cost, while meeting the design intent and achieving the desired aesthetic quality of panel layout and surface smoothness. The production of curved panels is mostly based on molds. Since the cost of mold fabrication often dominates the panel cost, there is strong incentive to use the same mold for multiple panels. We cast the major practical requirements for architectural surface paneling, including mold reuse, into a global optimization framework that interleaves discrete and continuous optimization steps to minimize production cost while meeting user-specified quality constraints. The search space for optimization is mainly generated through controlled deviation from the design surface and tolerances on positional and normal continuity between neighboring panels. A novel 6-dimensional metric space allows us to quickly compute approximate inter-panel distances, which dramatically improves the performance of the optimization and enables the handling of complex arrangements with thousands of panels. The practical relevance of our system is demonstrated by paneling solutions for real, cutting-edge architectural freeform design projects.

  16. The TDAQ Baseline Architecture

    CERN Multimedia

    Wickens, F J

    The Trigger-DAQ community is currently busy preparing material for the DAQ, HLT and DCS TDR. Over the last few weeks a very important step has been a series of meetings to complete agreement on the baseline architecture. An overview of the architecture indicating some of the main parameters is shown in figure 1. As reported at the ATLAS Plenary during the February ATLAS week, the main area where the baseline had not yet been agreed was around the Read-Out System (ROS) and details in the DataFlow. The agreed architecture has: Read-Out Links (ROLs) from the RODs using S-Link; Read-Out Buffers (ROB) sited near the RODs, mounted in a chassis - today assumed to be a PC, using PCI bus at least for configuration, control and monitoring. The baseline assumes data aggregation, in the ROB and/or at the output (which could either be over a bus or in the network). Optimization of the data aggregation will be made in the coming months, but the current model has each ROB card receiving input from 4 ROLs, and 3 such c...

  17. Architectural conceptual definition of the CAREM-25 reactor's control system

    International Nuclear Information System (INIS)

    This work presents the conceptual definition of the CAREM 25 reactor's digital and monitoring control system structure. The requirements of the system are analyzed and different implementation alternatives are studied where possible basic architectures of the system and its topology are considered and evaluated. (Author)

  18. Communication of IT-Architecture

    OpenAIRE

    H Koning

    2008-01-01

    This PhD thesis contains the results of various research activities that fall under the topic ‘communication of IT-architecture’. The term IT-architecture defines the various types of architecture that can be found in the domain of Information Technology (software architecture, enterprise architecture, etc). Our overall conclusion is that good communication of IT-architecture is a matter of “meaningful structuring”. This has been worked out in de following sub topics. A collection of 158 guid...

  19. Architecture of Chinese Virtual Observatory

    Science.gov (United States)

    Cui, Chen-Zhou; Zhao, Yong-Heng

    2004-06-01

    Virtual Observatory (VO) is brought forward under the background of progresses of astronomical technologies and information technologies. VO architecture design embodies the combination of above two technologies. As an introduction of VO, principle and workflow of Virtual Observatory are given firstly. Then the latest progress on VO architecture is introduced. Based on the Grid technology, layered architecture model and service-oriented architecture model are given for Chinese Virtual Observatory. In the last part of the paper, some problems on architecture design are discussed in detail.

  20. Robust Software Architecture for Robots

    Science.gov (United States)

    Aghazanian, Hrand; Baumgartner, Eric; Garrett, Michael

    2009-01-01

    Robust Real-Time Reconfigurable Robotics Software Architecture (R4SA) is the name of both a software architecture and software that embodies the architecture. The architecture was conceived in the spirit of current practice in designing modular, hard, realtime aerospace systems. The architecture facilitates the integration of new sensory, motor, and control software modules into the software of a given robotic system. R4SA was developed for initial application aboard exploratory mobile robots on Mars, but is adaptable to terrestrial robotic systems, real-time embedded computing systems in general, and robotic toys.

  1. Towards Architectural Information in Implementation

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Hansen, Klaus Marius

    2011-01-01

    Agile development methods favor speed and feature producing iterations. Software architecture, on the other hand, is ripe with techniques that are slow and not oriented directly towards implementation of costumers' needs. Thus, there is a major challenge in retaining architectural information in a...... fast-faced agile project. We propose to embed as much architectural information as possible in the central artefact of the agile universe, the code. We argue that thereby valuable architectural information is retained for (automatic) documentation, validation, and further analysis, based on a...... relatively small investment of effort. We outline some preliminary examples of architectural annotations in Java and Python and their applicability in practice....

  2. REST in practice Hypermedia and systems architecture

    CERN Document Server

    Webber, Jim; Robinson, Ian

    2010-01-01

    Why don't typical enterprise projects go as smoothly as projects you develop for the Web? Does the REST architectural style really present a viable alternative for building distributed systems and enterprise-class applications? In this insightful book, three SOA experts provide a down-to-earth explanation of REST and demonstrate how you can develop simple and elegant distributed hypermedia systems by applying the Web's guiding principles to common enterprise computing problems. You'll learn techniques for implementing specific Web technologies and patterns to solve the needs of a typical com

  3. Solid-phase molecular recognition of cytosine based on proton-transfer reaction. Part II. supramolecular architecture in the cocrystals of cytosine and its 5-Fluoroderivative with 5-Nitrouracil

    Directory of Open Access Journals (Sweden)

    Portalone Gustavo

    2011-09-01

    Full Text Available Abstract Background Cytosine is a biologically important compound owing to its natural occurrence as a component of nucleic acids. Cytosine plays a crucial role in DNA/RNA base pairing, through several hydrogen-bonding patterns, and controls the essential features of life as it is involved in genetic codon of 17 amino acids. The molecular recognition among cytosines, and the molecular heterosynthons of molecular salts fabricated through proton-transfer reactions, might be used to investigate the theoretical sites of cytosine-specific DNA-binding proteins and the design for molecular imprint. Results Reaction of cytosine (Cyt and 5-fluorocytosine (5Fcyt with 5-nitrouracil (Nit in aqueous solution yielded two new products, which have been characterized by single-crystal X-ray diffraction. The products include a dihydrated molecular salt (CytNit having both ionic and neutral hydrogen-bonded species, and a dihydrated cocrystal of neutral species (5FcytNit. In CytNit a protonated and an unprotonated cytosine form a triply hydrogen-bonded aggregate in a self-recognition ion-pair complex, and this dimer is then hydrogen bonded to one neutral and one anionic 5-nitrouracil molecule. In 5FcytNit the two neutral nucleobase derivatives are hydrogen bonded in pairs. In both structures conventional N-H...O, O-H...O, N-H+...N and N-H...N- intermolecular interactions are most significant in the structural assembly. Conclusion The supramolecular structure of the molecular adducts formed by cytosine and 5-fluorocytosine with 5-nitrouracil, CytNit and 5FcytNit, respectively, have been investigated in detail. CytNit and 5FcytNit exhibit widely differing hydrogen-bonding patterns, though both possess layered structures. The crystal structures of CytNit (Dpka = -0.7, molecular salt and 5FcytNit (Dpka = -2.0, cocrystal confirm that, at the present level of knowledge about the nature of proton-transfer process, there is not a strict correlation between the Dpka values

  4. Capital Architecture: Situating symbolism parallel to architectural methods and technology

    Science.gov (United States)

    Daoud, Bassam

    Capital Architecture is a symbol of a nation's global presence and the cultural and social focal point of its inhabitants. Since the advent of High-Modernism in Western cities, and subsequently decolonised capitals, civic architecture no longer seems to be strictly grounded in the philosophy that national buildings shape the legacy of government and the way a nation is regarded through its built environment. Amidst an exceedingly globalized architectural practice and with the growing concern of key heritage foundations over the shortcomings of international modernism in representing its immediate socio-cultural context, the contextualization of public architecture within its sociological, cultural and economic framework in capital cities became the key denominator of this thesis. Civic architecture in capital cities is essential to confront the challenges of symbolizing a nation and demonstrating the legitimacy of the government'. In today's dominantly secular Western societies, governmental architecture, especially where the seat of political power lies, is the ultimate form of architectural expression in conveying a sense of identity and underlining a nation's status. Departing with these convictions, this thesis investigates the embodied symbolic power, the representative capacity, and the inherent permanence in contemporary architecture, and in its modes of production. Through a vast study on Modern architectural ideals and heritage -- in parallel to methodologies -- the thesis stimulates the future of large scale governmental building practices and aims to identify and index the key constituents that may respond to the lack representation in civic architecture in capital cities.

  5. Sculpture Versus Architecture?

    Directory of Open Access Journals (Sweden)

    Alexander Rappaport

    2007-07-01

    Full Text Available Many critics consider Richard Serra the leading sculptor of the 20th century. He is famous not only for inventing something new in sculpture (abstract sculpture compositions existed before him, having been opened by constructivist vanguard of the beginning of the 20th century. Material selections by Vladimir Tatlin and sculptures by Osip Tsadkin, as well as compositions by Henry Moor appeared before Serra. Serra is famous for transferring his works' accent from the works as they are, which could be installed in any place, to their environment. That is he saw in the sculpture a key to understanding the urban space. His crude metal sheets and profiles, rectangular and curvilinear, exceeding regular scale of sculpture, come closer to architecture. Richard Serra places them near architectural constructions as checkpoints of intermediate scale category of space located between so-called «street furniture» – lamp posts, stalls, fountains and benches – and buildings, especially huge modern ones.But the matter is not only in the scale. Serra's sculptures are not only abstract compositions that harmoniously add to the space with their spacious scale. They have some mystery, some implicit sense appearing before a pedestrian as an enigma. Their mystique opposes both street furniture and architecture. But first of all it opposes the historical sculpture with its enigma always overshadowed by historical or biographical topic. Krylov's sculpture in the Summer Garden or Minin and Pozharsky's monument on the Red Square do not strike us, because we know that those monuments are erected IN COMMEMORATION of prominent people, as fellow citizens' tribute to their great contribution to the national history. But the crude metal sheets welded at different angles – what are they for? Who needs them?As an art critic, Edward Goldman, said, fame came to Richard Serra in 1989, when the sculpture composition Tilted Arc erected eight years before it was demolished by

  6. Architectural communication: Intra and extra activity of architecture

    Directory of Open Access Journals (Sweden)

    Stamatović-Vučković Slavica

    2013-01-01

    Full Text Available Apart from a brief overview of architectural communication viewed from the standpoint of theory of information and semiotics, this paper contains two forms of dualistically viewed architectural communication. The duality denotation/connotation (”primary” and ”secondary” architectural communication is one of semiotic postulates taken from Umberto Eco who viewed architectural communication as a semiotic phenomenon. In addition, architectural communication can be viewed as an intra and an extra activity of architecture where the overall activity of the edifice performed through its spatial manifestation may be understood as an act of communication. In that respect, the activity may be perceived as the ”behavior of architecture”, which corresponds to Lefebvre’s production of space.

  7. The flight telerobotic servicer: From functional architecture to computer architecture

    Science.gov (United States)

    Lumia, Ronald; Fiala, John

    1989-01-01

    After a brief tutorial on the NASA/National Bureau of Standards Standard Reference Model for Telerobot Control System Architecture (NASREM) functional architecture, the approach to its implementation is shown. First, interfaces must be defined which are capable of supporting the known algorithms. This is illustrated by considering the interfaces required for the SERVO level of the NASREM functional architecture. After interface definition, the specific computer architecture for the implementation must be determined. This choice is obviously technology dependent. An example illustrating one possible mapping of the NASREM functional architecture to a particular set of computers which implements it is shown. The result of choosing the NASREM functional architecture is that it provides a technology independent paradigm which can be mapped into a technology dependent implementation capable of evolving with technology in the laboratory and in space.

  8. ARQUITECTURAS INVISIBLES / Invisible Architecture

    Directory of Open Access Journals (Sweden)

    Francisco Javier Montero Fernández

    2012-11-01

    questions that go beyond quality. Political or commercial interests tend to confuse the opportunity for promotion with the merit of the project. It would be possible to number many competitions which have supposed a significant advance in architecture in the last century; a certain nostalgia for those times of debate which, together with other similar formulas such as entries in biennials, triennials or exhibitions, were capable of making empirical research from direct practice. On the contrary, today the policy framework of the architectural project is often defined in a manner foreign to real architecture, administratively dominated by a process that prioritizes legal and technical compliance over the quality of the project itself, confusing the means with the end. Criticism always aims at the author; it forgets the notable procedures which armed a jury gratuitously exonerated of responsibility or that legal framework that asphyxiates both architecture and the spirit of inquiry which should always prevail.This issue of the journal considers the assimilation of the competition into a research process parallel to an architecture united with quality and progress, an advanced architecture.

  9. The EPOS ICT Architecture

    Science.gov (United States)

    Jeffery, Keith; Harrison, Matt; Bailo, Daniele

    2016-04-01

    The EPOS-PP Project 2010-2014 proposed an architecture and demonstrated feasibility with a prototype. Requirements based on use cases were collected and an inventory of assets (e.g. datasets, software, users, computing resources, equipment/detectors, laboratory services) (RIDE) was developed. The architecture evolved through three stages of refinement with much consultation both with the EPOS community representing EPOS users and participants in geoscience and with the overall ICT community especially those working on research such as the RDA (Research Data Alliance) community. The architecture consists of a central ICS (Integrated Core Services) consisting of a portal and catalog, the latter providing to end-users a 'map' of all EPOS resources (datasets, software, users, computing, equipment/detectors etc.). ICS is extended to ICS-d (distributed ICS) for certain services (such as visualisation software services or Cloud computing resources) and CES (Computational Earth Science) for specific simulation or analytical processing. ICS also communicates with TCS (Thematic Core Services) which represent European-wide portals to national and local assets, resources and services in the various specific domains (e.g. seismology, volcanology, geodesy) of EPOS. The EPOS-IP project 2015-2019 started October 2015. Two work-packages cover the ICT aspects; WP6 involves interaction with the TCS while WP7 concentrates on ICS including interoperation with ICS-d and CES offerings: in short the ICT architecture. Based on the experience and results of EPOS-PP the ICT team held a pre-meeting in July 2015 and set out a project plan. The first major activity involved requirements (re-)collection with use cases and also updating the inventory of assets held by the various TCS in EPOS. The RIDE database of assets is currently being converted to CERIF (Common European Research Information Format - an EU Recommendation to Member States) to provide the basis for the EPOS-IP ICS Catalog. In

  10. Quality Management Activities for Software Architecture and Software Architecture Process

    OpenAIRE

    Hämäläinen, Niina

    2008-01-01

    Architecture processes are considerably new parts of organisations’ processes. These processes have the responsibility to aim at high quality and financially successful architectures. However, the activities which promote this aim are not clearly defined yet. This study reviews literature and practitioners’ experiences on quality management activities that could be suggested to promote the achievement of high quality software architectures and a good quality software a...

  11. From Architectural Acoustics to Acoustical Architecture Using Computer Simulation

    OpenAIRE

    Schmidt, Anne Marie Due; KIRKEGAARD, Poul Henning

    2005-01-01

    Architectural acoustics design has in the past been based on simple design rules. However, with a growing complexity in architectural acoustics and the emergence of room acoustic simulation programmes with considerable potential, it is now possible to subjectively analyse and evaluate acoustic properties prior to the actual construction of a building. With the right tools applied, acoustic design can become an integral part of the architectural design process. The aim of this paper is to inve...

  12. Evolution of genome architecture.

    Science.gov (United States)

    Koonin, Eugene V

    2009-02-01

    Charles Darwin believed that all traits of organisms have been honed to near perfection by natural selection. The empirical basis underlying Darwin's conclusions consisted of numerous observations made by him and other naturalists on the exquisite adaptations of animals and plants to their natural habitats and on the impressive results of artificial selection. Darwin fully appreciated the importance of heredity but was unaware of the nature and, in fact, the very existence of genomes. A century and a half after the publication of the "Origin", we have the opportunity to draw conclusions from the comparisons of hundreds of genome sequences from all walks of life. These comparisons suggest that the dominant mode of genome evolution is quite different from that of the phenotypic evolution. The genomes of vertebrates, those purported paragons of biological perfection, turned out to be veritable junkyards of selfish genetic elements where only a small fraction of the genetic material is dedicated to encoding biologically relevant information. In sharp contrast, genomes of microbes and viruses are incomparably more compact, with most of the genetic material assigned to distinct biological functions. However, even in these genomes, the specific genome organization (gene order) is poorly conserved. The results of comparative genomics lead to the conclusion that the genome architecture is not a straightforward result of continuous adaptation but rather is determined by the balance between the selection pressure, that is itself dependent on the effective population size and mutation rate, the level of recombination, and the activity of selfish elements. Although genes and, in many cases, multigene regions of genomes possess elaborate architectures that ensure regulation of expression, these arrangements are evolutionarily volatile and typically change substantially even on short evolutionary scales when gene sequences diverge minimally. Thus, the observed genome

  13. Future of information architecture

    CERN Document Server

    Baofu, Peter

    2008-01-01

    The Future of Information Architecture examines issues surrounding why information is processed, stored and applied in the way that it has, since time immemorial. Contrary to the conventional wisdom held by many scholars in human history, the recurrent debate on the explanation of the most basic categories of information (eg space, time causation, quality, quantity) has been misconstrued, to the effect that there exists some deeper categories and principles behind these categories of information - with enormous implications for our understanding of reality in general. To understand this, the b

  14. Architecture Building Sustainability

    Institute of Scientific and Technical Information of China (English)

    DAVID HENDRICKSON

    2006-01-01

    @@ Leading architectural design and engineering firm, Skidmore,Owings, & Merrill (SOM), is renowned for pushing the envelope, masterminding some of the world's most cutting edge and enduring structural masterpieces - America's tallest building, the Sears Tower,in the firm's home city of Chicago, the 88-story Jinmao Tower in Shanghai, and the Freedom Tower in New York City, successor to the fallen World Trade Center complex,are among the well known projects in its building portfolio. SOM's next high profile assignment, the Pearl River Tower, in Guangzhou is one no less worthy of this tradition.

  15. Mobile networks architecture

    CERN Document Server

    Perez, Andre

    2013-01-01

    This book explains the evolutions of architecture for mobiles and summarizes the different technologies:- 2G: the GSM (Global System for Mobile) network, the GPRS (General Packet Radio Service) network and the EDGE (Enhanced Data for Global Evolution) evolution;- 3G: the UMTS (Universal Mobile Telecommunications System) network and the HSPA (High Speed Packet Access) evolutions:- HSDPA (High Speed Downlink Packet Access),- HSUPA (High Speed Uplink Packet Access),- HSPA+;- 4G: the EPS (Evolved Packet System) network.The telephone service and data transmission are the

  16. Architecture for robot intelligence

    Science.gov (United States)

    Peters, II, Richard Alan (Inventor)

    2004-01-01

    An architecture for robot intelligence enables a robot to learn new behaviors and create new behavior sequences autonomously and interact with a dynamically changing environment. Sensory information is mapped onto a Sensory Ego-Sphere (SES) that rapidly identifies important changes in the environment and functions much like short term memory. Behaviors are stored in a DBAM that creates an active map from the robot's current state to a goal state and functions much like long term memory. A dream state converts recent activities stored in the SES and creates or modifies behaviors in the DBAM.

  17. Microgrids architectures and control

    CERN Document Server

    Hatziargyriou, Nikos

    2014-01-01

    Microgrids are the most innovative area in the electric power industry today. Future microgrids could exist as energy-balanced cells within existing power distribution grids or stand-alone power networks within small communities. A definitive presentation on all aspects of microgrids, this text examines the operation of microgrids - their control concepts and advanced architectures including multi-microgrids. It takes a logical approach to overview the purpose and the technical aspects of microgrids, discussing the social, economic and environmental benefits to power system operation. The bo

  18. Advanced router architectures

    CERN Document Server

    Kloth, Axel K

    2005-01-01

    Routers, switches, and transmission equipment form the backbone of the Internet, yet many users and service technicians do not understand how these nodes really work.Advanced Router Architectures addresses how components of advanced routers work together and how they are integrated with each other. This book provides the background behind why these building blocks perform certain functions, and how the function is implemented in general use. It offers an introduction to the subject matter that is intended to trigger deeper interest from the reader. The book explains, for example, why traffic m

  19. Architecture of reconciliation

    OpenAIRE

    Tyrrell, Roger; Astridge, S.

    2008-01-01

    One quarter of all the world’s cranes are located in the fastest growing city in the world; Dubai. The paradox is, that in striving for global economic recognition Dubai has become a parody of itself, a mythology of forms; an adult Disneyland built upon the silent deserts of the past. The emphasis upon ‘landmark’ architecture is primarily driven and controlled by global economics and the quest for recognition upon the global stage. As a result, these new forms lack empathy and humility and ha...

  20. Mind and Language Architecture

    OpenAIRE

    Robert K. Logan

    2010-01-01

    A distinction is made between the brain and the mind. The architecture of the mind and language is then described within a neo-dualistic framework. A model for the origin of language based on emergence theory is presented. The complexity of hominid existence due to tool making, the control of fire and the social cooperation that fire required gave rise to a new level of order in mental activity and triggered the simultaneous emergence of language and conceptual thought. The mind is shown to h...

  1. Chipless RFID reader architecture

    CERN Document Server

    Karmakar, Nemai Chandra; Kalansuriya, Prasanna

    2013-01-01

    In the era of information communication technology (ICT), radio frequency identification (RFID) has been going through tremendous development. RFID technology has the potential of replacing barcodes due to its large information carrying capacity, flexibility in operations, and applications. The deployment of RFID has been hindered by its cost. However, with the advent of low powered ICs, energy scavenging techniques, and low-cost chipless tags, RFID technology has achieved significant development. This book addresses the new reader architecture, presents fundamentals of chipless RFID systems,

  2. Light Rhythms in Architecture

    DEFF Research Database (Denmark)

    Bülow, Katja

    2013-01-01

    On one hand, urban lighting expresses itself in a complex visual environment made by the interplay by between many separate lighting schemes, as street lighting, shop lighting, luminous commercials etc. On the other, a noticeable order of patterns occurs, when lighting is observed as luminous...... formation and rhythm. When integrated into an architectural concept, electrical lighting non-intended for poetic composition has the ability to contribute to place, time, and function-telling aspects of places in urban contexts. Urban environments are information wise challenging to pre-historic human...... instincts, but they can be met by careful selection and adjustment of existing light situations....

  3. Die-stacking architecture

    CERN Document Server

    Xie, Yuan

    2015-01-01

    The emerging three-dimensional (3D) chip architectures, with their intrinsic capability of reducing the wire length, promise attractive solutions to reduce the delay of interconnects in future microprocessors. 3D memory stacking enables much higher memory bandwidth for future chip-multiprocessor design, mitigating the ""memory wall"" problem. In addition, heterogenous integration enabled by 3D technology can also result in innovative designs for future microprocessors. This book first provides a brief introduction to this emerging technology, and then presents a variety of approaches to design

  4. Summarization of firewall architecture

    International Nuclear Information System (INIS)

    With the rapid development of the Internet, the attacks to the networks from the hackers are increasing considerably, and the topics concerning the network system security and firewall are becoming more and more active. A hot point is the firewall technology. This article mainly discusses the firewalls at data packet and application level, then combine them together in order to form a powerful and safe firewall architecture: the Screened Subnet and the Proxy Gateway Introduce structure of stream filtration in the technology of the firewall. (authors)

  5. The Architectural Organization of Human Stem Cell Cycle Regulatory Machinery

    OpenAIRE

    Stein, Gary S.; Stein, Janet L.; van Wijnen, Andre J.; Lian, Jane B.; Montecino, Martin; Medina, Ricardo(Instituto de Matemática e Computação, Universidade Federal de Itajubá, Itajubá, Minas Gerais, Brazil); Kapinas, Kristie; Ghule, Prachi; Grandy, Rodrigo; Zaidi, Sayyed K.; Becker, Klaus A.

    2012-01-01

    Two striking features of human embryonic stem cells that support biological activity are an abbreviated cell cycle and reduced complexity to nuclear organization. The potential implications for rapid proliferation of human embryonic stem cells within the context of sustaining pluripotency, suppressing phenotypic gene expression and linkage to simplicity in the architectural compartmentalization of regulatory machinery in nuclear microenvironments is explored. Characterization of the molecular...

  6. Enterprise architecture evaluation using architecture framework and UML stereotypes

    Directory of Open Access Journals (Sweden)

    Narges Shahi

    2014-08-01

    Full Text Available There is an increasing need for enterprise architecture in numerous organizations with complicated systems with various processes. Support for information technology, organizational units whose elements maintain complex relationships increases. Enterprise architecture is so effective that its non-use in organizations is regarded as their institutional inability in efficient information technology management. The enterprise architecture process generally consists of three phases including strategic programing of information technology, enterprise architecture programing and enterprise architecture implementation. Each phase must be implemented sequentially and one single flaw in each phase may result in a flaw in the whole architecture and, consequently, in extra costs and time. If a model is mapped for the issue and then it is evaluated before enterprise architecture implementation in the second phase, the possible flaws in implementation process are prevented. In this study, the processes of enterprise architecture are illustrated through UML diagrams, and the architecture is evaluated in programming phase through transforming the UML diagrams to Petri nets. The results indicate that the high costs of the implementation phase will be reduced.

  7. ISTTOK real-time architecture

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Ivo S., E-mail: ivoc@ipfn.ist.utl.pt; Duarte, Paulo; Fernandes, Horácio; Valcárcel, Daniel F.; Carvalho, Pedro J.; Silva, Carlos; Duarte, André S.; Neto, André; Sousa, Jorge; Batista, António J.N.; Hekkert, Tiago; Carvalho, Bernardo B.

    2014-03-15

    Highlights: • All real-time diagnostics and actuators were integrated in the same control platform. • A 100 μs control cycle was achieved under the MARTe framework. • Time-windows based control with several event-driven control strategies implemented. • AC discharges with exception handling on iron core flux saturation. • An HTML discharge configuration was developed for configuring the MARTe system. - Abstract: The ISTTOK tokamak was upgraded with a plasma control system based on the Advanced Telecommunications Computing Architecture (ATCA) standard. This control system was designed to improve the discharge stability and to extend the operational space to the alternate plasma current (AC) discharges as part of the ISTTOK scientific program. In order to accomplish these objectives all ISTTOK diagnostics and actuators relevant for real-time operation were integrated in the control system. The control system was programmed in C++ over the Multi-threaded Application Real-Time executor (MARTe) which provides, among other features, a real-time scheduler, an interrupt handler, an intercommunications interface between code blocks and a clearly bounded interface with the external devices. As a complement to the MARTe framework, the BaseLib2 library provides the foundations for the data, code introspection and also a Hypertext Transfer Protocol (HTTP) server service. Taking advantage of the modular nature of MARTe, the algorithms of each diagnostic data processing, discharge timing, context switch, control and actuators output reference generation, run on well-defined blocks of code named Generic Application Module (GAM). This approach allows reusability of the code, simplified simulation, replacement or editing without changing the remaining GAMs. The ISTTOK control system GAMs run sequentially each 100 μs cycle on an Intel{sup ®} Q8200 4-core processor running at 2.33 GHz located in the ATCA crate. Two boards (inside the ATCA crate) with 32 analog

  8. ISTTOK real-time architecture

    International Nuclear Information System (INIS)

    Highlights: • All real-time diagnostics and actuators were integrated in the same control platform. • A 100 μs control cycle was achieved under the MARTe framework. • Time-windows based control with several event-driven control strategies implemented. • AC discharges with exception handling on iron core flux saturation. • An HTML discharge configuration was developed for configuring the MARTe system. - Abstract: The ISTTOK tokamak was upgraded with a plasma control system based on the Advanced Telecommunications Computing Architecture (ATCA) standard. This control system was designed to improve the discharge stability and to extend the operational space to the alternate plasma current (AC) discharges as part of the ISTTOK scientific program. In order to accomplish these objectives all ISTTOK diagnostics and actuators relevant for real-time operation were integrated in the control system. The control system was programmed in C++ over the Multi-threaded Application Real-Time executor (MARTe) which provides, among other features, a real-time scheduler, an interrupt handler, an intercommunications interface between code blocks and a clearly bounded interface with the external devices. As a complement to the MARTe framework, the BaseLib2 library provides the foundations for the data, code introspection and also a Hypertext Transfer Protocol (HTTP) server service. Taking advantage of the modular nature of MARTe, the algorithms of each diagnostic data processing, discharge timing, context switch, control and actuators output reference generation, run on well-defined blocks of code named Generic Application Module (GAM). This approach allows reusability of the code, simplified simulation, replacement or editing without changing the remaining GAMs. The ISTTOK control system GAMs run sequentially each 100 μs cycle on an Intel® Q8200 4-core processor running at 2.33 GHz located in the ATCA crate. Two boards (inside the ATCA crate) with 32 analog

  9. Looking for an Alternative.

    Science.gov (United States)

    Kennedy, Jack

    1999-01-01

    Argues that high school newspapers might do well to create stronger ties with alternative weeklies. Discusses issues of niche marketing, alternative content, and alternative presentation. Notes that high school papers could learn a lot from alternative newspapers. (SR)

  10. Bernard Tschumi Draws Architecture!

    Directory of Open Access Journals (Sweden)

    Gevork Hartoonian

    2014-08-01

    Full Text Available Bernard Tschumi’s delineation prepared for the Museu de Arte Contemporânea provides the starting point for this essay, which discusses the historicity of drawing and highlights the horizontality and the verticality that structure architecture’s contrast with the pictorial realm. Juxtaposing a freehand sketch with the digital image of the same project, Tschumi moves to address the paradox concerning the position of the body and drawing. This drawing also speaks for the reversal in the position of the body brought about by digital reproductivity.The reversal alludes to Tschumi’s theorization of architecture in terms of space and event. These, I will argue, are anticipated in The Manhattan Transcripts (1981 where a set of freehand drawings is used to evoke a filmic mood wherein the image is projected parallel to the spectator’s seated position. The essay goes further, suggesting that the theatricality permeating the present architecture is part of the shift from horizontality to the painterly, and yet the phenomenon is not merely a technical issue. Rather, it alludes to architecture’s dialogical rapport with painting at work since the Renaissance.

  11. Architectures for intelligent machines

    Science.gov (United States)

    Saridis, George N.

    1991-01-01

    The theory of intelligent machines has been recently reformulated to incorporate new architectures that are using neural and Petri nets. The analytic functions of an intelligent machine are implemented by intelligent controls, using entropy as a measure. The resulting hierarchical control structure is based on the principle of increasing precision with decreasing intelligence. Each of the three levels of the intelligent control is using different architectures, in order to satisfy the requirements of the principle: the organization level is moduled after a Boltzmann machine for abstract reasoning, task planning and decision making; the coordination level is composed of a number of Petri net transducers supervised, for command exchange, by a dispatcher, which also serves as an interface to the organization level; the execution level, include the sensory, planning for navigation and control hardware which interacts one-to-one with the appropriate coordinators, while a VME bus provides a channel for database exchange among the several devices. This system is currently implemented on a robotic transporter, designed for space construction at the CIRSSE laboratories at the Rensselaer Polytechnic Institute. The progress of its development is reported.

  12. Chromosome Architecture and Genome Organization

    OpenAIRE

    Giorgio Bernardi

    2015-01-01

    How the same DNA sequences can function in the three-dimensional architecture of interphase nucleus, fold in the very compact structure of metaphase chromosomes and go precisely back to the original interphase architecture in the following cell cycle remains an unresolved question to this day. The strategy used to address this issue was to analyze the correlations between chromosome architecture and the compositional patterns of DNA sequences spanning a size range from a few hundreds to a few...

  13. Resource Oriented Architecture and REST

    OpenAIRE

    LUCCHI ROBERTO; MILLOT MICHEL; ELFERS Christian

    2008-01-01

    In light of the emerging discussion on Resource Oriented Architectures (ROA) and REST technology platform as solutions for Spatial Data distributed Infrastructures, the aim of this document is capture Resource Oriented Architectures principles and assess the feasibility as well as the advantages of using such approach compared with Service Oriented Architectures (SOA). Although most of the comments are domain independent we will use the INSPIRE (and the OGC services) infrastructure that is cu...

  14. Specialized Hardware Architecture for Smartphones

    Directory of Open Access Journals (Sweden)

    Rohit Kumar,

    2014-05-01

    Full Text Available Smartphones provides us the capability of a typical computer with absolute mobility and small form factor. But the hardware, software architecture of smartphone is significantly different from the conventional hardware and software architectures. The feature and architecture of the processors is totally different the traditional processor as these processors are developed to cope-up with fewer energy availability with smartphones or any other ultra portable devices. Key-Words:

  15. Specialized Hardware Architecture for Smartphones

    OpenAIRE

    Rohit Kumar; Lokesh Pawar

    2014-01-01

    Smartphones provides us the capability of a typical computer with absolute mobility and small form factor. But the hardware, software architecture of smartphone is significantly different from the conventional hardware and software architectures. The feature and architecture of the processors is totally different the traditional processor as these processors are developed to cope-up with fewer energy availability with smartphones or any other ultra portable devices. Key-Words:

  16. Design theory versus architectural design

    OpenAIRE

    W R Spillers

    1986-01-01

    This paper is an attempt to track the path of architectural design both on design-theoretical and on practical (computer-aided design) planes. It begins with the practical problems of design which can be couched in terms of mathematical programming problems. The potential for applications of artificial intelligence and knowledge-based systems in architectural design is then considered. Last the place of architectural design within design theory is discussed.

  17. Identification of Sustainable Architecture Dimensions

    OpenAIRE

    Leila Etminan; Siavash Rashidi Sharif Abad; Mansour Nikpor

    2014-01-01

    The main purpose in this research is identification of sustainable architecture dimensions. Nowadays, one of the most necessary complicated and main specifications of architecture with which architects are face is the issue of sustainability in various types of its interpretations. The issue of sustainability is interpretable and general according to many aspects. Therefore, it is necessary to identify this concept (architecture and its related categories). At the beginning of this discussion...

  18. A provider based accounting architecture

    OpenAIRE

    Parhonyi, R.; Quartel, D.; Pras, A.

    2002-01-01

    The paper presents a novel content accounting architecture. Content accounting is becoming increasingly important since it is anticipated that in the near future more billable content will be published on the Internet. The presented architecture has a distributed functionality and an innovative view with respect to the payment system that is incorporated. The architecture enables outsourcing of the accounting functions. In particular, it is shown how Internet service providers can be involved...

  19. Synthesis - Based Software Architecture Design

    OpenAIRE

    Tekinerdogan, Bedir; Aksit, Mehmet; Akşit, Mehmet

    2001-01-01

    During the last decade several architecture design approaches have been introduced. These approaches however have to cope with several obstacles and software architecture design remains a difficult problem. To cope with these obstacles this chapter introduces a novel architecture design approach. The approach is based on the concept of synthesis that is a well-known and effective problem solving technique in traditional engineering disciplines. The approach is illustrated for the design of an...

  20. Architecture in the network society

    DEFF Research Database (Denmark)

    2004-01-01

    Under the theme Architecture in the Network Society, participants were invited to focus on the dialog and sharing of knowledge between architects and other disciplines and to reflect on, and propose, new methods in the design process, to enhance and improve the impact of information technology...... on architecture. This conference and the past history of eCAADe is an example on establishing a social network for the sharing of knowledge regarding the use of computers in architectural education and research....

  1. Towards a networkArchitecture

    DEFF Research Database (Denmark)

    Rüdiger, Bjarne; Tournay, Bruno

    2001-01-01

    Planche, bidrag til DAL-konkurrencen. Hvor industrien har været inspirationen for udviklingen af den moderne arkitektur, er IT det tekniske og æstetiske grundlag for den spirende NetworkArchitecture. Computeren og netværker af computerne er således mere end en metafor for NetworkArchitecture....... NetworkArchitecture består af intelligente byggekomponenter forbundet med hinanden i et netværk og i interaktion med omgivelser....

  2. Architectural Operations in Cloud Computing

    OpenAIRE

    Ragnar Skúlason 1982

    2011-01-01

    Rapid scalability is important in cloud computing in order to serve growing communities and optimize hardware costs. This scalability can be hard to achieve, especially in software with static architecture. Changing software architecture of running systems on multiple devices over the Internet is a hard and delicate process as updating live software can cause faults and failures while software systems are being restarted. Taking the study of software architecture to the dynamics of the cloud ...

  3. Architectural Theory: A Construction Site

    Directory of Open Access Journals (Sweden)

    Ákos Moravánszky

    2014-07-01

    Full Text Available Around 1968 we saw the birth of a new architectural theory as the conjunction of architectural history and politically engaged architectural criticism. Not the aesthetics of architecture, but architecture itself in its structural relations with social life became the focus of attention. As a result of this development, it is no longer possible to study architectural history without a critical reflection on the method of the study itself and without a grade of interdisciplinarity. Traditional methods of historiography and iconography have been replaced by new approaches configured by psychoanalysis, deconstruction, cultural studies etc. Appropriation has become the proof of criticality both in architectural theory and in design; however, the understanding of the concepts and methods of other disciplines is basically metaphorical. The problem for a school of architecture lies not in the ‘criticality’ of the kind of architectural theory we described as emerging from the spirit of 1968, but in its discursive nature. The disciplinary specificity of architecture resists a discursive approach, and architectural students frequently question the usefulness of theory which undermines the notion of the ‘project’, without articulating a constructive proposal. Projectivity does not seem to provide an answer; its claim of performativity lacks the program to regain its organising power over contributions from other specialised disciplines and practices. Theory should focus on the terms of our discipline, which are so close to our ‘core beliefs’ regarding architecture that we usually take their meaning for granted. It would be wrong to see this focus of theory as a withdrawal into the realm of language. Indeed, after a period of theory alienating architects and the general public, it could now create a rhetoric to influence our understanding of our environment, which is itself organised on the level of language. The requirement that theory should

  4. Integrated Data Assimilation Architecture Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Integrated Data Assimilation Architecture (IDAA) addresses the fundamental problem of command, control, and communications systems interoperability....

  5. Software synthesis using generic architectures

    Science.gov (United States)

    Bhansali, Sanjay

    1993-01-01

    A framework for synthesizing software systems based on abstracting software system designs and the design process is described. The result of such an abstraction process is a generic architecture and the process knowledge for customizing the architecture. The customization process knowledge is used to assist a designer in customizing the architecture as opposed to completely automating the design of systems. Our approach using an implemented example of a generic tracking architecture which was customized in two different domains is illustrated. How the designs produced using KASE compare to the original designs of the two systems, and current work and plans for extending KASE to other application areas are described.

  6. Architectural Drawing - an Animate Field

    DEFF Research Database (Denmark)

    Hougaard, Anna Katrine

    2015-01-01

    Architectural drawing is changing because architects today draw with computers. Due to this change digital diagrams employed by computational architectural practices are often emphasized as powerful structures of control and organisation in the design process. But there are also diagrams, which do...... important affordance of architectural drawing as a ¬hybrid between the openness of hand-sketching and the rule-based-ness of diagramming, an affordance which might be useful in the migrational zone of current architectural drawing where traditional hand drawing techniques and computer drawing techniques...

  7. Software architecture as a set of architectural design decisions

    NARCIS (Netherlands)

    Jansen, Anton; Bosch, Jan; Nord, R; Medvidovic, N; Krikhaar, R; Khrhaar, R; Stafford, J; Bosch, J

    2006-01-01

    Software architectures have high costs for change, are complex, and erode during evolution. We believe these problems are partially due to knowledge vaporization. Currently, almost all the knowledge and information about the design decisions the architecture is based on are implicitly embedded in th

  8. On-chip bus standards in a broadcast architecture

    OpenAIRE

    Romaguera i Restudis, Josep-Oriol

    2012-01-01

    [ANGLÈS] This final project has been developed in the School of Electrical Engineering (in Aalto University) and its main goal is to value whether AMBA (Advanced Microcontroller Bus Architecture) is a good option to develop an on-chip broadcast architecture. To carry it out, various alternatives are taken in account: use full AMBA (with all its signals), use CAN (Controller Area Network) bus instead of AMBA, and use modified AMBA (using only the signals that will be used). Once one alternativ...

  9. Supramolecular architectures and nanostructures at metal surfaces

    Science.gov (United States)

    Barth, J. V.; Weckesser, J.; Lin, N.; Dmitriev, A.; Kern, K.

    The controlled formation of non-covalent bonds (H-bonding, metal-ligand interactions) is the key ingredient for the fabrication of supramolecular architectures and nanostructures. Upon deposition of molecular building blocks at well-defined surfaces, this issue can be directly addressed. Scanning tunneling microscopy observations are presented, which provide insight into the interaction of functional groups on metal substrates at the molecular level. In particular, carboxylic acids were employed: (4-[(pyrid-4-yl-ethynyl)]-benzoic acid (PEBA), 4-[trans-2-(pyrid-4-yl-vinyl)]-benzoic acid (PVBA) and trimesic acid (1,3,5-benzenetricarboxylic acid, TMA), which could be stabilized in a flat geometry at the surface. By choosing the appropriate substrate material and symmetry, the sensitive balance of intermolecular and molecule-substrate interactions can be tuned to obtain well-defined supramolecular architectures and nanostructures. The head-to-tail hydrogen bonding of the related rod-like species PEBA and PVBA stabilizes molecular rows on Ag(111). The subtle difference in the molecular geometries is reflected in the lateral ordering: While 2-D islanding is encountered with PEBA, 1-D nanogratings of supramolecular chiral H-bonded twin chains evolve for PVBA. The threefold symmetry of TMA in conjunction with the self-complementarity of its exodentate groups accounts for the formation of H-bonded honeycomb networks on Cu(100) at low temperatures. Metal-ligand interactions were probed with PVBA and TMA at Cu surfaces at ambient temperature. Deprotonation of the carboxyl moiety takes place, which readily interacts with Cu adatoms evaporated from step edges. This leads to a head-to-head pairing of PVBA on Cu(111) and cloverleaf-shaped Cu-TMA coordination compounds on Cu(001).

  10. The Architecture of Exoplanets

    Science.gov (United States)

    Hatzes, Artie P.

    2016-05-01

    Prior to the discovery of exoplanets our expectations of their architecture were largely driven by the properties of our solar system. We expected giant planets to lie in the outer regions and rocky planets in the inner regions. Planets should probably only occupy orbital distances 0.3-30 AU from the star. Planetary orbits should be circular, prograde and in the same plane. The reality of exoplanets have shattered these expectations. Jupiter-mass, Neptune-mass, Superearths, and even Earth-mass planets can orbit within 0.05 AU of the stars, sometimes with orbital periods of less than one day. Exoplanetary orbits can be eccentric, misaligned, and even in retrograde orbits. Radial velocity surveys gave the first hints that the occurrence rate increases with decreasing mass. This was put on a firm statistical basis with the Kepler mission that clearly demonstrated that there were more Neptune- and Superearth-sized planets than Jupiter-sized planets. These are often in multiple, densely packed systems where the planets all orbit within 0.3 AU of the star, a result also suggested by radial velocity surveys. Exoplanets also exhibit diversity along the main sequence. Massive stars tend to have a higher frequency of planets ( ≈ 20-25 %) that tend to be more massive ( M≈ 5-10 M_{Jup}). Giant planets around low mass stars are rare, but these stars show an abundance of small (Neptune and Superearth) planets in multiple systems. Planet formation is also not restricted to single stars as the Kepler mission has discovered several circumbinary planets. Although we have learned much about the architecture of planets over the past 20 years, we know little about the census of small planets at relatively large ( a>1 AU) orbital distances. We have yet to find a planetary system that is analogous to our own solar system. The question of how unique are the properties of our own solar system remains unanswered. Advancements in the detection methods of small planets over a wide range

  11. Agent-Oriented Enterprise Architecture: new approach for Enterprise Architecture

    Directory of Open Access Journals (Sweden)

    Babak Darvish Rouhani

    2012-11-01

    Full Text Available Nowadays, utilizing EA by enterprises with medium and long term goals causes improvement in their productivity and competitiveness. With respect to varied changes in enterprise's business activities and attitudes, flexibility in information systems of EA is a crucial factor. Agent's capacities in implementation of complex systems goal convince huge enterprises to use agent oriented architecture in their EA programs. Combination of EA and agent oriented architecture introduces a new attitude in order to make a better conditions for huge enterprises with complex information systems. This paper firstly enumerates the current problems of Enterprise Architecture, and then agent-oriented Enterprise Architecture is introduced as a comprehensive solution for eliminating mentioned defects deals raised. The main results of agent-oriented Enterprise Architecture includes: more flexibility in organizational change, reengineering organizational processes and comprehensive coverage of all activities of huge and complex organizations with no other lateral requirements.

  12. How architecture students gain and apply knowledge of sustainable architecture

    DEFF Research Database (Denmark)

    Donovan, Elizabeth; Holder, Anna

    2016-01-01

    This paper will reflect on understandings of architectural pedagogy and the integration of sustainability into architectural design education. This is framed within an understanding of the construction industry’s role in the production of waste. Despite the complexity of global environmental crises......, architectural educators have the opportunity to do more to address this. We begin with a discussion of contemporary literature and policy concerning education for sustainability in architecture, articulating the particular approaches in development within higher education. This is then compared with critical...... understandings of how architects synthesise different types of knowledge while designing, raising questions about the ‘match’ between educational experiences and subsequent behaviours in practice. Taking an example from Denmark, we outline the approach of Aarhus School of Architecture, where sustainability...

  13. From Architectural Acoustics to Acoustical Architecture Using Computer Simulation

    DEFF Research Database (Denmark)

    Schmidt, Anne Marie Due; Kirkegaard, Poul Henning

    2005-01-01

    Architectural acoustics design has in the past been based on simple design rules. However, with a growing complexity in architectural acoustics and the emergence of room acoustic simulation programmes with considerable potential, it is now possible to subjectively analyse and evaluate acoustic...... properties prior to the actual construction of a building. With the right tools applied, acoustic design can become an integral part of the architectural design process. The aim of this paper is to investigate the field of application that an acoustic simulation programme can have during an architectural...... the first phases in the architectural process and set out a reverse strategy for simulation programmes to do so - from developing acoustics from given spaces to developing spaces from given acoustics...

  14. On the Architectural Engineering Competences in Architectural Design

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning

    2007-01-01

    In 1997 a new education in Architecture & Design at Department of Architecture and Design, Aalborg University was started with 50 students. During the recent years this number has increased to approximately 100 new students each year, i.e. approximately 500 students are following the 3 years...... bachelor (BSc) and the 2 years master (MSc) programme. The first 5 semesters are common for all students followed by 5 semesters with specialization into Architectural Design, Urban Design, Industrial Design or Digital Design. The present paper gives a short summary of the architectural engineering...... competences related to the specialization in Architectural Design. A detailed presentation can be found at the homepage: www.aod.aau.dk....

  15. Selecting an Architecture for a Safety-Critical Distributed Computer System with Power, Weight and Cost Considerations

    Science.gov (United States)

    Torres-Pomales, Wilfredo

    2014-01-01

    This report presents an example of the application of multi-criteria decision analysis to the selection of an architecture for a safety-critical distributed computer system. The design problem includes constraints on minimum system availability and integrity, and the decision is based on the optimal balance of power, weight and cost. The analysis process includes the generation of alternative architectures, evaluation of individual decision criteria, and the selection of an alternative based on overall value. In this example presented here, iterative application of the quantitative evaluation process made it possible to deliberately generate an alternative architecture that is superior to all others regardless of the relative importance of cost.

  16. Architecture des contemplatifs

    OpenAIRE

    2005-01-01

    Architecture des contemplatifs. — Il serait nécessaire de comprendre un jour, et probablement ce jour est-il proche, ce qui manque avant tout à nos grandes villes : des lieux de silence, spacieux et forts étendus, destinés à la méditation, pourvus de hautes et de longues galeries pour les intempéries ou le trop ardent soleil, où ne pénètre nulle rumeur de voitures ni de crieurs, et où une bienséance plus subtile interdirait même au prêtre l’oraison à voix haute : des édifices et des jardins q...

  17. Art and Architectural Space

    DEFF Research Database (Denmark)

    Unterrainer, Walter

    2014-01-01

    and its content. The urban and spatial question goes far beyond museums and other buildings for art: how in democratic societies should public spaces be supported by art and how can public art support ´cityness´ and meaning versus spaces of consumerism. Famous but egocentric buildings with the main......art and architectural space museums and other exhibition spaces or how artists learn to love architects Over the last two decades, innumerable new museums, art galleries and other exhibition spaces have been built and opened all over the globe. The most extreme growth happened in China, where the...... number of museums went up from 300 by 1980 to estimated 3000 museums by 2015. In urban discourses, new museums and buildings for art have been considered as drivers for ´cultural sustainability´ of cities. The notion is diffuse and the reality is more an economic centred ´city branding´ to help the...

  18. Architectural Practice as Research

    DEFF Research Database (Denmark)

    Hougaard, Anna Katrine

    2015-01-01

    , qualitative and quantitative, scientific and artistic methods pollinate each other, and an attempt to set up a span for ‘research by design’ to unfold in, rather than a rigid definition. In mutual exploitation architectural writing, drawing and potentially the construction of objects with properties embodied......The paper discusses a kind of research which lies between ‘research by design’ and ‘artistic research’. The term ‘research by design’ is reconstructed to include artistic ways of working, and the paper is an exemplification of a research practice, which seeks to let subjective and objective...... in them, is the very research. This approach is framed by Deleuze’s reading of Bergson’s intuitive method and Peirce’s concept abduction, both methods which concern creative processes, material production and organisation, and the breakthrough of novelty....

  19. Naval open systems architecture

    Science.gov (United States)

    Guertin, Nick; Womble, Brian; Haskell, Virginia

    2013-05-01

    For the past 8 years, the Navy has been working on transforming the acquisition practices of the Navy and Marine Corps toward Open Systems Architectures to open up our business, gain competitive advantage, improve warfighter performance, speed innovation to the fleet and deliver superior capability to the warfighter within a shrinking budget1. Why should Industry care? They should care because we in Government want the best Industry has to offer. Industry is in the business of pushing technology to greater and greater capabilities through innovation. Examples of innovations are on full display at this conference, such as exploring the impact of difficult environmental conditions on technical performance. Industry is creating the tools which will continue to give the Navy and Marine Corps important tactical advantages over our adversaries.

  20. Helicoid and Architectural application

    Directory of Open Access Journals (Sweden)

    Laura Inzerillo

    2012-11-01

    Full Text Available This paper deals with the issue of a long time research concerning the representation of complex surfaces in descriptive geometry. The ability to use the different techniques of representation aims to achieve results never thought before. In the University of Palermo, at the Engineering School, the research involved the study on simplifying a more elaborated way to represent the geometry and its applications in buildings architecture and related engineering plants and equipment. Specifically, is here reported the application of the proposed method to represent one of the most used surfaces in the buildings design. It concerns a helicoid surface represented in orthogonal axonometric projecting. The method is essentially based on the experimental homology that, by the way, is extensively documented in the bibliography section of this paper.

  1. CONRAD Software Architecture

    Science.gov (United States)

    Guzman, J. C.; Bennett, T.

    2008-08-01

    The Convergent Radio Astronomy Demonstrator (CONRAD) is a collaboration between the computing teams of two SKA pathfinder instruments, MeerKAT (South Africa) and ASKAP (Australia). Our goal is to produce the required common software to operate, process and store the data from the two instruments. Both instruments are synthesis arrays composed of a large number of antennas (40 - 100) operating at centimeter wavelengths with wide-field capabilities. Key challenges are the processing of high volume of data in real-time as well as the remote mode of operations. Here we present the software architecture for CONRAD. Our design approach is to maximize the use of open solutions and third-party software widely deployed in commercial applications, such as SNMP and LDAP, and to utilize modern web-based technologies for the user interfaces, such as AJAX.

  2. High-Tech Architecture

    Directory of Open Access Journals (Sweden)

    Özlem Eşsiz

    1999-05-01

    Full Text Available The technological development in building and construction area, bring with the new construction systems and the new products. The aim of this study is to define the High Tech concept, and set the common and basic characteristics of High Tech applications. During 1970’s High Tech was born and developed in Britain. Especially British Architects Richard Rogers, Michael Hopkins, Norman Foster, Nicholas Grimshaw and Ian Ritchie are the leaders of this style. Their architecture show the machine aesthetic and use of industrial revoluation materials such as glass and steel. The reasons for wide usage of this technology in building constructions are; the ease of renewing the structural and installation systems by the changing technology and giving monumentality to the prestige buildings. High Tech building which we have many examples of give their occupants a lot of opportunities and also they can adapt itself to the time.

  3. Thermal Space in Architecture

    DEFF Research Database (Denmark)

    Petersen, Mads Dines

    buildings. However at the bottom of this lies an understanding of how we inhabit the space in our buildings and how we historically have adapted to the changing conditions of the seasons in our buildings. Through an increased understanding of this adaptability of and to our buildings, our work with spaces...... and understanding of spaces in buildings can change significantly and instead of the creation of frozen geometrical spaces, thermal spaces can be created as it is suggested in meteorological architecture where functions are distributed in relation to temperature gradients. This creates an interesting contrast...... to the current discussions about passive houses that today is starting to set the standards in a Scandinavian context, where the highly controlled indoor environment is in focus relying on mechanical ventilation, creating spaces with a narrow margin for comfort. One can raise the question if re...

  4. An Embodied Architecture

    Directory of Open Access Journals (Sweden)

    Frances Downing

    2012-10-01

    Full Text Available An architecture of the body is emerging out of theories of biology, complexity, and systems through the use of an evolving organism as its metaphor. Autopoiesis is the term used by biologists to describe the realm of existence for a living organism as it slides between the interchange of structure and information. Incoming information is filtered through the organism for its usefulness in the art of staying alive. Structural or organizational changes evolve as the organism adjusts to new information. To remain a viable organism—to survive—means that an entity must keep evolving without surrendering identity. Humans must maintain an embodied identity, often referred to as an organized self (Maturana & Varela, 1980, 1987, while viably exchanging information with other entities and the environment. This operation creates a topological boundary across which the communication takes place. Cognitive theorists and researchers have proposed that the animal condition is one of Embodied Realism; that is, animals such as we humans, are embodied, using our bodies to create basic metaphors, and, that we do this in a“real” world. The role of cognition in this equation is to allow humans the use of embodiment to explore abstract ideas through metaphor—such as “grasping an idea” (Lakoff &Johnson, 2003. In doing so, it allows the invention of an evolving language that refers to things “outside” our skin,like other entities and places. Autopoiesis describes the activities at the “edge” or boundary of an organism. The linguistic act can, therefore, be identified as fundamental medium for communication in the edge, between inside and outside, that assures the autopoiesis of place.In our own bodies, flesh is the biological manifest of the edge or boundary condition. Our understanding of flesh is that it is another of our organs; and at the same time, all organs are also bounded by flesh. It serves as a porous filter, delicate and complicated

  5. Planning in subsumption architectures

    Science.gov (United States)

    Chalfant, Eugene C.

    1994-01-01

    A subsumption planner using a parallel distributed computational paradigm based on the subsumption architecture for control of real-world capable robots is described. Virtual sensor state space is used as a planning tool to visualize the robot's anticipated effect on its environment. Decision sequences are generated based on the environmental situation expected at the time the robot must commit to a decision. Between decision points, the robot performs in a preprogrammed manner. A rudimentary, domain-specific partial world model contains enough information to extrapolate the end results of the rote behavior between decision points. A collective network of predictors operates in parallel with the reactive network forming a recurrrent network which generates plans as a hierarchy. Details of a plan segment are generated only when its execution is imminent. The use of the subsumption planner is demonstrated by a simple maze navigation problem.

  6. Secure Storage Architectures

    Energy Technology Data Exchange (ETDEWEB)

    Aderholdt, Ferrol [Tennessee Technological University; Caldwell, Blake A [ORNL; Hicks, Susan Elaine [ORNL; Koch, Scott M [ORNL; Naughton, III, Thomas J [ORNL; Pogge, James R [Tennessee Technological University; Scott, Stephen L [Tennessee Technological University; Shipman, Galen M [ORNL; Sorrillo, Lawrence [ORNL

    2015-01-01

    The purpose of this report is to clarify the challenges associated with storage for secure enclaves. The major focus areas for the report are: - review of relevant parallel filesystem technologies to identify assets and gaps; - review of filesystem isolation/protection mechanisms, to include native filesystem capabilities and auxiliary/layered techniques; - definition of storage architectures that can be used for customizable compute enclaves (i.e., clarification of use-cases that must be supported for shared storage scenarios); - investigate vendor products related to secure storage. This study provides technical details on the storage and filesystem used for HPC with particular attention on elements that contribute to creating secure storage. We outline the pieces for a a shared storage architecture that balances protection and performance by leveraging the isolation capabilities available in filesystems and virtualization technologies to maintain the integrity of the data. Key Points: There are a few existing and in-progress protection features in Lustre related to secure storage, which are discussed in (Chapter 3.1). These include authentication capabilities like GSSAPI/Kerberos and the in-progress work for GSSAPI/Host-keys. The GPFS filesystem provides native support for encryption, which is not directly available in Lustre. Additionally, GPFS includes authentication/authorization mechanisms for inter-cluster sharing of filesystems (Chapter 3.2). The limitations of key importance for secure storage/filesystems are: (i) restricting sub-tree mounts for parallel filesystem (which is not directly supported in Lustre or GPFS), and (ii) segregation of hosts on the storage network and practical complications with dynamic additions to the storage network, e.g., LNET. A challenge for VM based use cases will be to provide efficient IO forwarding of the parallel filessytem from the host to the guest (VM). There are promising options like para-virtualized filesystems to

  7. On Assessing the Complexity of Software Architectures

    OpenAIRE

    Zhao, Jianjun

    2001-01-01

    This paper proposes some new architectural metrics which are appropriate for evaluating the architectural attributes of a software system. The main feature of our approach is to assess the complexity of a software architecture by analyzing various types of architectural dependences in the architecture.

  8. Open system architecture for CIM

    Energy Technology Data Exchange (ETDEWEB)

    1989-01-01

    This book addresses the need for an open system architecture for computer integrated manufacturing (CIM-OSA) which provides: a general definition of the scope and nature of CIM, guidelines for implementation, a description of constituent systems and subsystems, a modular framework complying with international standards. CIM-OSA defines an architecture for the building of a computer managed and integrated manufacturing enterprise. The architecture is subdivided into three architectural levels: a requirements definition model, a design specification model, and an implementation description model. This architecture provides building blocks for the design and execution of a CIM system. To develop such an architecture, ESPRIT Project 688, A European Computer Integrated Manufacturing Architecture (AMICE), was launched in 1986. Under the management of ESPRIT Consortium AMICE, 21 companies from 7 European countries are cooperating in the project. This book reports on the results obtained in the project and gives a detailed description of CIM-OSA. The architecture will be employed in the next generation CIM systems.

  9. Software Architecture for Autonomous Spacecraft

    Science.gov (United States)

    Shih, Jimmy S.

    1997-01-01

    The thesis objective is to design an autonomous spacecraft architecture to perform both deliberative and reactive behaviors. The Autonomous Small Planet In-Situ Reaction to Events (ASPIRE) project uses the architecture to integrate several autonomous technologies for a comet orbiter mission.

  10. Towards Innovative and Inclusive Architecture

    DEFF Research Database (Denmark)

    Grangaard, Sidse

    2016-01-01

    Acknowledging that the Danish Buildings Regulations is having an impact on the design of inclusive architecture, a Danish government agency focuses on new models for the accessibility requirements in the future Building Regulations supporting an innovative and inclusive architecture. In order to...

  11. Approaching Environmental Issues in Architecture

    DEFF Research Database (Denmark)

    Petersen, Mads Dines; Knudstrup, Mary-Ann

    2013-01-01

    The research presented here takes its point of departure in the design process with a specific focus on how it is approached when designing energy efficient architecture. This is done through a case-study of a design process in a Danish architectural office. This study shows the importance of...

  12. On Information System Security Architecture

    Institute of Scientific and Technical Information of China (English)

    ChunfangJiang; ChaoyuanYue; JianguoZuo

    2004-01-01

    The current studies on security architecture and information system security architecture (ISSA) are surveyed in this paper, and some types and their features of ISSA are discussed. Then, the structural elements of ISSA are analyzed, and the constructing steps for ISSA are proposed.

  13. Control architectures for IT management

    International Nuclear Information System (INIS)

    This paper summaries the three financial control architectures for IT department in an enterprise or organization, they are unallocated cost center, allocated cost center and profit center, analyses the characteristics of them and in the end gives the detailed suggestions for choosing these control architectures. (authors)

  14. An Architectural Strategy for Change.

    Science.gov (United States)

    Holt, Raymond M., Ed.

    This volume presents the proceedings of the preconference institute of the Architecture for Public Libraries Committee of Library Administration Division's Building and Equipment section. The keynote address raises questions about architecture in a strategy for change. The remaining 14 articles and presentations are divided into five sections:…

  15. Pushouts in software architecture design

    OpenAIRE

    Riché, T. L.; Gonçalves, Rui; Marker, B.; D. Batory

    2012-01-01

    A classical approach to program derivation is to progressively extend a simple specification and then incrementally refine it to an implementation. We claim this approach is hard or impractical when reverse engineering legacy software architectures. We present a case study that shows optimizations and pushouts--in addition to refinements and extensions--are essential for practical stepwise development of complex software architectures.

  16. Dynamic Weather Routes Architecture Overview

    Science.gov (United States)

    Eslami, Hassan; Eshow, Michelle

    2014-01-01

    Dynamic Weather Routes Architecture Overview, presents the high level software architecture of DWR, based on the CTAS software framework and the Direct-To automation tool. The document also covers external and internal data flows, required dataset, changes to the Direct-To software for DWR, collection of software statistics, and the code structure.

  17. Nano-textured polymers for future architectural needs

    Directory of Open Access Journals (Sweden)

    Cees W.M. Bastiaansen

    2013-12-01

    Full Text Available The rapid developments in molecular sciences like nanotechnology and self-organizing molecular systems generate a wealth of new materials and functions. In comparison to electronics the application in architecture remains somewhat underexposed. New functionalities in optics, responsive mechanics, sensing and adjustable permeation for gases and water might add to new opportunities in providing for personal comfort and energy management in houses and professional buildings.With a number of examples we demonstrate how complex but well-controlled molecular architectures provide functionalities worthwhile of being integrated in architectural designs. Optical coatings are capable of switching colors or reflectivity, creating possibilities for design but also for the control of thermal transmission through windows. They respond to temperature, light intensity, or both. Selectively-reflective thin polymer layers or paint pigments can be designed to switch between infrared and visible regions of the solar spectrum. Coatings can be designed to change their topology and thereby their appearance, of interest for in-house light management, or just for aesthetic appeal. Plastic materials can be imbued with the property of autonomous sun tracking and provided morphing behavior upon contact with moisture or exposure to light. Many of these materials need further developments to meet the requirements for building integration with respect to robustness, lifetime, and the like, which will only be accomplished after demonstration of interest from the architectural world.

  18. Competitive Cost Analysis of Alternative Powertrain Technologies.

    OpenAIRE

    Redelbach, Martin; Propfe, Bernd; Friedrich, Horst E.

    2012-01-01

    This paper examines the cost competitiveness of different electrified propulsion technologies from hybrid cars to full battery electric vehicles in the time horizon 2010 to 2020. The assessment shows that the current TCO gaps for alternative drivetrains will increasingly converge over time mainly driven by decreasing production cost. However, the cost-efficiency of different powertrain architectures depends highly on the mileage a user expects to drive per year. In the mid-run, hybrid elec...

  19. Urban architecture in urban renewal

    DEFF Research Database (Denmark)

    Holmgren, Steen; Svensson, Ole

    2001-01-01

    In Denmark new issues in urban renewal are being introduced. Legislation on urban renewal now demands that residents be invited to take an active part in the development of their urban area. And urban renewal is increasingly taking place in inner suburbs which are recently built, complex and...... without obvious architectural value. These issues raise pertinent questions: what urban architectural problems and qualities exist in the complex, inner suburbs? What differences exist between professionals' and residents' perceptions and assessments of urban architecture? How can a shared language of...... urban architecture be developed? This research project attempts to answer these questions through a discourse on theories and methods and the development of "dialogue methods" by which professionals can learn about residents' perception of the urban architecture of their area, thus achieving a better...

  20. E-Learning in Architecture

    DEFF Research Database (Denmark)

    Juvancic, Matevz; Mullins, Michael; Zupancic, Tadeja

    2012-01-01

    E-learning in architectural and spatially related fields can be examined from two different perspectives, each having quite specific and complex implications. By discussing e-learning in architecture we inspect the scope of e-learning tools and practices within the architectural domain, the visual...... nature of education and professional training of architects, and the state of the art of e-learning implementations, together with their practicality and limitations. While these are the first areas that come to mind when considering e-learning in relation to architecture, there is another also very...... relevant and sometimes overlooked aspect: that of e-learning about architecture. In the latter, we introduce not only the professional but also the broader, non-expert public into the process of acting within, and shaping of, their spatial environments. This aspect raises burning questions regarding...

  1. Legacy application integration architecture

    OpenAIRE

    Grom, Jure

    2009-01-01

    Information needs of modern businesses are constantly growing. Own development of a business information system is time consuming and expensive but, as an alternative, using smaller partial solutions doesn’t cover all user needs. Decision to buy a universal solution, often results in only part of it being actively and efficiently used. By application integration we manage to achieve efficient use of applications, since by linking them, we enable sharing of business logics among applications a...

  2. LANDSCAPE ARCHITECTURE IN FISHERIES

    OpenAIRE

    Branka Aničić; Tomislav Treer

    1997-01-01

    The improvement of living conditions and technology and particularly devel- oped conscious about the environment, influenced radical changes of the approach to the agricultural production in western civilization. This is related to the fisheries, too, which also undergo significant changes in Croatia during recent years. The trend of higher aquaculture production and catches in open waters and in the sea is substituted by the seeking for alternative possibilities and higher social and cultura...

  3. Architecture Governance: The Importance of Architecture Governance for Achieving Operationally Responsive Ground Systems

    Science.gov (United States)

    Kolar, Mike; Estefan, Jeff; Giovannoni, Brian; Barkley, Erik

    2011-01-01

    Topics covered (1) Why Governance and Why Now? (2) Characteristics of Architecture Governance (3) Strategic Elements (3a) Architectural Principles (3b) Architecture Board (3c) Architecture Compliance (4) Architecture Governance Infusion Process. Governance is concerned with decision making (i.e., setting directions, establishing standards and principles, and prioritizing investments). Architecture governance is the practice and orientation by which enterprise architectures and other architectures are managed and controlled at an enterprise-wide level

  4. Digital Architecture Planning Model

    Energy Technology Data Exchange (ETDEWEB)

    Oxstrand, Johanna Helene [Idaho National Lab. (INL), Idaho Falls, ID (United States). Light Water Reactor Sustainability Program (LWRS); Al Rashdan, Ahmad Yahya Mohammad [Idaho National Lab. (INL), Idaho Falls, ID (United States). Light Water Reactor Sustainability Program (LWRS); Bly, Aaron Douglas [Idaho National Lab. (INL), Idaho Falls, ID (United States). Light Water Reactor Sustainability Program (LWRS); Rice, Brandon Charles [Idaho National Lab. (INL), Idaho Falls, ID (United States). Light Water Reactor Sustainability Program (LWRS); Fitzgerald, Kirk [Idaho National Lab. (INL), Idaho Falls, ID (United States). Light Water Reactor Sustainability Program (LWRS); Wilson, Keith Leon [Idaho National Lab. (INL), Idaho Falls, ID (United States). Light Water Reactor Sustainability Program (LWRS)

    2016-03-01

    As part of the U.S. Department of Energy’s Light Water Reactor Sustainability Program, the Digital Architecture (DA) Project focuses on providing a model that nuclear utilities can refer to when planning deployment of advanced technologies. The digital architecture planning model (DAPM) is the methodology for mapping power plant operational and support activities into a DA that unifies all data sources needed by the utilities to operate their plants. The DA is defined as a collection of information technology capabilities needed to support and integrate a wide spectrum of real-time digital capabilities for performance improvements of nuclear power plants. DA can be thought of as integration of the separate instrumentation and control and information systems already in place in nuclear power plants, which are brought together for the purpose of creating new levels of automation in plant work activities. A major objective in DAPM development was to survey all key areas that needed to be reviewed in order for a utility to make knowledgeable decisions regarding needs and plans to implement a DA at the plant. The development was done in two steps. First, researchers surveyed the nuclear industry in order to learn their near-term plans for adopting new advanced capabilities and implementing a network (i.e., wireless and wire) infrastructure throughout the plant, including the power block. Secondly, a literature review covering regulatory documents, industry standards, and technical research reports and articles was conducted. The objective of the review was to identify key areas to be covered by the DAPM, which included the following: 1. The need for a DA and its benefits to the plant 2. Resources required to implement the DA 3. Challenges that need to be addressed and resolved to implement the DA 4. Roles and responsibilities of the DA implementation plan. The DAPM was developed based on results from the survey and the literature review. Model development, including

  5. Software Architecture Design : Evaluation and Transformation

    OpenAIRE

    Bosch, Jan; Molin, Peter

    1997-01-01

    Since the architecture of a software system constrains the non-functional requirements, the decisions taken during architectural design have a large impact in the resulting system. An architectural design method is presented that employs iterative evaluation and transformation of the software architecture in order to satisfy the non-functional requirements (NFRs). Architecture evaluation is performed by using scenarios, simulation, mathematical modelling and reasoning. The architecture can be...

  6. Chromosome Architecture and Genome Organization

    Science.gov (United States)

    Bernardi, Giorgio

    2015-01-01

    How the same DNA sequences can function in the three-dimensional architecture of interphase nucleus, fold in the very compact structure of metaphase chromosomes and go precisely back to the original interphase architecture in the following cell cycle remains an unresolved question to this day. The strategy used to address this issue was to analyze the correlations between chromosome architecture and the compositional patterns of DNA sequences spanning a size range from a few hundreds to a few thousands Kilobases. This is a critical range that encompasses isochores, interphase chromatin domains and boundaries, and chromosomal bands. The solution rests on the following key points: 1) the transition from the looped domains and sub-domains of interphase chromatin to the 30-nm fiber loops of early prophase chromosomes goes through the unfolding into an extended chromatin structure (probably a 10-nm “beads-on-a-string” structure); 2) the architectural proteins of interphase chromatin, such as CTCF and cohesin sub-units, are retained in mitosis and are part of the discontinuous protein scaffold of mitotic chromosomes; 3) the conservation of the link between architectural proteins and their binding sites on DNA through the cell cycle explains the “mitotic memory” of interphase architecture and the reversibility of the interphase to mitosis process. The results presented here also lead to a general conclusion which concerns the existence of correlations between the isochore organization of the genome and the architecture of chromosomes from interphase to metaphase. PMID:26619076

  7. Bioclimatic Architecture; Arquitectura Bioclimatica

    Energy Technology Data Exchange (ETDEWEB)

    Rubenak, Joseph C. [A.G.I.S.A., Mexico D.F. (Mexico)

    2005-07-01

    The idea of the Bioclimatic Architecture comes from the term used by the Olgyay brothers, to emphasize the relations and connections between life, the climate and the bonds of these natural factors with the design. These base a method so that the development of the design responds in terms of function and comfort to the climatic implications that give context to the architectonic projects. The central objective is the creation of expressive spaces and aesthetically harmonic whose characteristics privilege the function of the building with optimal conditions for physical and psychological comfort for those who live, operate or use the building. [Spanish] La idea de la arquitectura bioclimatica proviene del termino utilizado por los hermanos Olgyay, para resaltar las relaciones y enlaces entre la vida, el clima y los vinculos de estos factores naturales con el diseno. Estos fundamentan un metodo para que el desarrollo del diseno responda en terminos de funcion y confort a las implicaciones climaticas que dan contexto a los proyectos arquitectonicos. El objetivo central es la creacion de espacios expresivos y esteticamente armonicos cuyas caracteristicas privilegien la funcion del inmueble con optimas condiciones de comodidad fisica y psicologica para quienes viven, operan o utilizan el edificio.

  8. Geometry - Construction - Architecture

    Directory of Open Access Journals (Sweden)

    Riccardo Migliari

    2012-06-01

    Full Text Available Geometry, in Drawing, is suffering from a profound crisis, more than other disciplines of the area, and this crisis has confined it, according a few, within a field of study of top-grade specialization, that only few scholars are interested in. The reason for this crisis can be found in the changes that were induced, during the last thirty years, by the advent of the information technology, but not only there. It can also be found, in my opinion, in the rightful ambition of all of us architects to carry out research, an ambition that the traditional Geometry, both descriptive and more in general graphical, could not satisfy. In fact, that part of descriptive geometry, which deals with the graphical representation on a plane of three-dimensional objects, has been outclassed by 3D modelling, both in simplicity of execution and in quality of the results. Whilst the graphical geometry has been neglected even by the mathematicians, during the axiomatic turning-point of the 1920s, a part from some exceptions - Coxeter - and a few recent reconsiderations. Yet, geometry continues to play a leading role in drawing, in general, and in architecture, in particular, and I refer to the historical studies, to the studies of surfaces, to the relation with art and, last but not least important, to teaching.

  9. System architecture with XML

    CERN Document Server

    Daum, Berthold

    2002-01-01

    XML is bringing together some fairly disparate groups into a new cultural clash: document developers trying to understand what a transaction is, database analysts getting upset because the relational model doesn''t fit anymore, and web designers having to deal with schemata and rule based transformations. The key to rising above the confusion is to understand the different semantic structures that lie beneath the standards of XML, and how to model the semantics to achieve the goals of the organization. A pure architecture of XML doesn''t exist yet, and it may never exist as the underlying technologies are so diverse. Still, the key to understanding how to build the new web infrastructure for electronic business lies in understanding the landscape of these new standards.If your background is in document processing, this book will show how you can use conceptual modeling to model business scenarios consisting of business objects, relationships, processes, and transactions in a document-centric way. Database des...

  10. Planetary cubesats - mission architectures

    Science.gov (United States)

    Bousquet, Pierre W.; Ulamec, Stephan; Jaumann, Ralf; Vane, Gregg; Baker, John; Clark, Pamela; Komarek, Tomas; Lebreton, Jean-Pierre; Yano, Hajime

    2016-07-01

    Miniaturisation of technologies over the last decade has made cubesats a valid solution for deep space missions. For example, a spectacular set 13 cubesats will be delivered in 2018 to a high lunar orbit within the frame of SLS' first flight, referred to as Exploration Mission-1 (EM-1). Each of them will perform autonomously valuable scientific or technological investigations. Other situations are encountered, such as the auxiliary landers / rovers and autonomous camera that will be carried in 2018 to asteroid 1993 JU3 by JAXA's Hayabusas 2 probe, and will provide complementary scientific return to their mothership. In this case, cubesats depend on a larger spacecraft for deployment and other resources, such as telecommunication relay or propulsion. For both situations, we will describe in this paper how cubesats can be used as remote observatories (such as NEO detection missions), as technology demonstrators, and how they can perform or contribute to all steps in the Deep Space exploration sequence: Measurements during Deep Space cruise, Body Fly-bies, Body Orbiters, Atmospheric probes (Jupiter probe, Venus atmospheric probes, ..), Static Landers, Mobile landers (such as balloons, wheeled rovers, small body rovers, drones, penetrators, floating devices, …), Sample Return. We will elaborate on mission architectures for the most promising concepts where cubesat size devices offer an advantage in terms of affordability, feasibility, and increase of scientific return.

  11. Array processor architecture

    Science.gov (United States)

    Barnes, George H. (Inventor); Lundstrom, Stephen F. (Inventor); Shafer, Philip E. (Inventor)

    1983-01-01

    A high speed parallel array data processing architecture fashioned under a computational envelope approach includes a data base memory for secondary storage of programs and data, and a plurality of memory modules interconnected to a plurality of processing modules by a connection network of the Omega gender. Programs and data are fed from the data base memory to the plurality of memory modules and from hence the programs are fed through the connection network to the array of processors (one copy of each program for each processor). Execution of the programs occur with the processors operating normally quite independently of each other in a multiprocessing fashion. For data dependent operations and other suitable operations, all processors are instructed to finish one given task or program branch before all are instructed to proceed in parallel processing fashion on the next instruction. Even when functioning in the parallel processing mode however, the processors are not locked-step but execute their own copy of the program individually unless or until another overall processor array synchronization instruction is issued.

  12. Secure Cloud Architecture

    Directory of Open Access Journals (Sweden)

    Kashif Munir

    2013-02-01

    Full Text Available Cloud computing is set of resources and services offered through the Internet. Cloud services are delivered from data centers located throughout the world. Cloud computing facilitates its consumers by providing virtual resources via internet. The biggest challenge in cloud computing is the security and privacy problems caused by its multi-tenancy nature and the outsourcing of infrastructure, sensitive data and critical applications. Enterprises are rapidly adopting cloud services for their businesses, measures need to be developed so that organizations can be assured of security in their businesses and can choose a suitable vendor for their computing needs. Cloud computing depends on the internet as a medium for users to access the required services at any time on pay-per-use pattern. However this technology is still in its initial stages of development, as it suffers from threats and vulnerabilities that prevent the users from trusting it. Various malicious activitiesfrom illegal users have threatened this technology such as data misuse, inflexible access control and limited monitoring. The occurrence of these threats may result into damaging or illegal access of critical and confidential data of users. In this paper we identify the most vulnerable security threats/attacks in cloud computing, which will enable both end users and vendors to know a bout the k ey security threats associated with cloud computing and propose relevant solution directives to strengthen security in the Cloud environment. We also propose secure cloud architecture for organizations to strengthen the security.

  13. Marc Treib: Representing Landscape Architecture

    DEFF Research Database (Denmark)

    Braae, Ellen Marie

    The editor of Representing Landscape Architecture, Marc Treib, argues that there is good reason to evaluate the standard practices of representation that landscape architects have been using for so long. In the rush to the promised land of computer design these practices are now in danger of being...... left by the wayside. The 14 often both fitting and well crafted contributions of this publication offer an approach to how landscape architecture has been and is currently represented; in the design study, in presentation, in criticism, and in the creation of landscape architecture....

  14. Software Support for LIRAC Architecture

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Memory limitations are always a focus of computer architecture. The live range aware cache(LIRAC) offers a way to reduce memory access using live range information. In the LIRAC system, scratch data need not be written back if the data will no longer be used. Three kinds of software support developed for LIRAC architecture use compiler analyses, binary analyses, and trace analyses. Trace analysis results show that LIRAC can eliminate 29% of cache write-backs on average and up to 83% in the best case for the SPEC CPU 2000 benchmark. These software techniques can show the feasibility and potential benefit of the LIRAC architecture.

  15. Digital design and computer architecture

    CERN Document Server

    Harris, David

    2010-01-01

    Digital Design and Computer Architecture is designed for courses that combine digital logic design with computer organization/architecture or that teach these subjects as a two-course sequence. Digital Design and Computer Architecture begins with a modern approach by rigorously covering the fundamentals of digital logic design and then introducing Hardware Description Languages (HDLs). Featuring examples of the two most widely-used HDLs, VHDL and Verilog, the first half of the text prepares the reader for what follows in the second: the design of a MIPS Processor. By the end of D

  16. Transcriptional profiles of supragranular-enriched genes associate with corticocortical network architecture in the human brain.

    Science.gov (United States)

    Krienen, Fenna M; Yeo, B T Thomas; Ge, Tian; Buckner, Randy L; Sherwood, Chet C

    2016-01-26

    The human brain is patterned with disproportionately large, distributed cerebral networks that connect multiple association zones in the frontal, temporal, and parietal lobes. The expansion of the cortical surface, along with the emergence of long-range connectivity networks, may be reflected in changes to the underlying molecular architecture. Using the Allen Institute's human brain transcriptional atlas, we demonstrate that genes particularly enriched in supragranular layers of the human cerebral cortex relative to mouse distinguish major cortical classes. The topography of transcriptional expression reflects large-scale brain network organization consistent with estimates from functional connectivity MRI and anatomical tracing in nonhuman primates. Microarray expression data for genes preferentially expressed in human upper layers (II/III), but enriched only in lower layers (V/VI) of mouse, were cross-correlated to identify molecular profiles across the cerebral cortex of postmortem human brains (n = 6). Unimodal sensory and motor zones have similar molecular profiles, despite being distributed across the cortical mantle. Sensory/motor profiles were anticorrelated with paralimbic and certain distributed association network profiles. Tests of alternative gene sets did not consistently distinguish sensory and motor regions from paralimbic and association regions: (i) genes enriched in supragranular layers in both humans and mice, (ii) genes cortically enriched in humans relative to nonhuman primates, (iii) genes related to connectivity in rodents, (iv) genes associated with human and mouse connectivity, and (v) 1,454 gene sets curated from known gene ontologies. Molecular innovations of upper cortical layers may be an important component in the evolution of long-range corticocortical projections. PMID:26739559

  17. Telemedicine system interoperability architecture: concept description and architecture overview.

    Energy Technology Data Exchange (ETDEWEB)

    Craft, Richard Layne, II

    2004-05-01

    In order for telemedicine to realize the vision of anywhere, anytime access to care, it must address the question of how to create a fully interoperable infrastructure. This paper describes the reasons for pursuing interoperability, outlines operational requirements that any interoperability approach needs to consider, proposes an abstract architecture for meeting these needs, identifies candidate technologies that might be used for rendering this architecture, and suggests a path forward that the telemedicine community might follow.

  18. Agent-Oriented Enterprise Architecture: new approach for Enterprise Architecture

    OpenAIRE

    Babak Darvish Rouhani; Fatemeh Nikpay

    2012-01-01

    Nowadays, utilizing EA by enterprises with medium and long term goals causes improvement in their productivity and competitiveness. With respect to varied changes in enterprise's business activities and attitudes, flexibility in information systems of EA is a crucial factor. Agent's capacities in implementation of complex systems goal convince huge enterprises to use agent oriented architecture in their EA programs. Combination of EA and agent oriented architecture introduces a new attitude i...

  19. A Quality Based Method to Analyze Software Architectures

    Directory of Open Access Journals (Sweden)

    Farzaneh Hoseini Jabali

    2011-07-01

    Full Text Available In order to produce and develop a software system, it is necessary to have a method of choosing a suitable software architecture which satisfies the required quality attributes and maintains a trade-off between sometimes conflicting ones. Each software architecture includes a set of design decisions for each of which there are various alternatives, satisfying the quality attributes differently. At the same time various stakeholders with various quality goals participate in decision-making. In this paper a numerical method is proposed that based on the quality attributes selects the suitable software architecture for a certain software. In this method, for each design decision, different alternatives are compared in view of a certain quality attribute, and the other way around. Multi-criteria decision-making methods are used and, at the same time, time and cost constraints are considered in decision-making, too. The proposed method applies the stakeholders' opinions in decision-making according to the degree of their importance and helps the architect to select the best software architecture with more certainty.

  20. SYSTEM ARCHITECTURE AND ENTERPRISE ARCHITECTURE: A JUXTA POSITION?#

    Directory of Open Access Journals (Sweden)

    S.J. Benade

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: A systems approach to creating a system is discussed. The system engineering process, and specifically the system architecture process, is formulated and applied to a typical (physical system, enterprise, and project. These lead to the concepts of system architecture (SA, enterprise architecture (EA, and project architecture (PA respectively. Similarities and inter-relationships among these architectures and related methodologies are investigated, seeking better interaction among them. ‘Work’ is proposed as an important conceptual building-block of these architectures, properly defined as activity with associated inputs, outputs, governances, and mechanisms. Techniques such as functional analysis, process modelling, and task analysis are used to demonstrate the inter-relationships among these apparently unrelated organisational perspectives of product, process, and project.

    AFRIKAANSE OPSOMMING ’n Stelselbenadering tot die daarstelling van ’n stelsel word bespreek. Die stelselingenieurs-wese,en spesifiek die stelselargitektuurproses, word geformuleer en toegepas op ’n tipiese (fisiese stelsel, onderneming, en projek. Dit lei tot die konsepte van stelselargitektuur (SA, ondernemingsargitektuur (OA, en projekargitektuur (PA. Ooreenkomste en verwant-skappe tussen hierdie argitekture word ontleed om beter onderlinge interaksie te bewerkstellig. ’n Belangrike konseptuele bousteen van hierdie argitekture word voorgestel as ‘werk’, behoorlik gedefinieer as aktiwiteit met gepaardgaande insette, uitsette, kontroles, en meganismes. Tegnieke soos funksionele analise, prosesmodellering, en taakanalise word gebruik om die onderlinge verbande tussen hierdie skynbaar onverwante organisatoriese perspektiewe van produk, projek, en proses, te demonstreer.

  1. ADAPTABLE ALTERNATE REALITY GAMES PLATFORM

    Directory of Open Access Journals (Sweden)

    Liviu-Adrian Cotfas

    2013-12-01

    Full Text Available In this paper, we present an alternate reality games platform that facilitates the creation of ARG projects with different themes and sizes. The platform is well integrated with the most important social media networks, thus facilitating both the involvement of the public and the creation of a more engaging interaction for the participants. A cloud-based architecture was used in order to allow the platform to easily accommodate projects of various sizes and to provide a good level of scalability. The platform is fully localizable in any language and multiple languages can be used at once to create projects that target users from different countries. An initial project that uses gamification to create an immersive learning environment has been created around the developed platform. The project combines professional and public feedback in order to provide an enhanced learning experience.

  2. Commentary on ‘Software architectures and mobility: A roadmap’

    OpenAIRE

    Wermelinger, Michel; Bandara, Arosha

    2010-01-01

    Medvidovic and Edwards provide in their paper (henceforth referred to as the Roadmap) a good survey of the variety of architectural concerns and approaches to mobility. This commentary is intended to complement the Roadmap, discussing additional or alternative concepts, issues and approaches. The ubiquity of mobile computing devices has enabled communication and access to information and services at an unprecedented scale. Novel application domains and technological advances make the boun...

  3. Convolutional neural network architectures for predicting DNA–protein binding

    Science.gov (United States)

    Zeng, Haoyang; Edwards, Matthew D.; Liu, Ge; Gifford, David K.

    2016-01-01

    Motivation: Convolutional neural networks (CNN) have outperformed conventional methods in modeling the sequence specificity of DNA–protein binding. Yet inappropriate CNN architectures can yield poorer performance than simpler models. Thus an in-depth understanding of how to match CNN architecture to a given task is needed to fully harness the power of CNNs for computational biology applications. Results: We present a systematic exploration of CNN architectures for predicting DNA sequence binding using a large compendium of transcription factor datasets. We identify the best-performing architectures by varying CNN width, depth and pooling designs. We find that adding convolutional kernels to a network is important for motif-based tasks. We show the benefits of CNNs in learning rich higher-order sequence features, such as secondary motifs and local sequence context, by comparing network performance on multiple modeling tasks ranging in difficulty. We also demonstrate how careful construction of sequence benchmark datasets, using approaches that control potentially confounding effects like positional or motif strength bias, is critical in making fair comparisons between competing methods. We explore how to establish the sufficiency of training data for these learning tasks, and we have created a flexible cloud-based framework that permits the rapid exploration of alternative neural network architectures for problems in computational biology. Availability and Implementation: All the models analyzed are available at http://cnn.csail.mit.edu. Contact: gifford@mit.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307608

  4. Synthetic staggered architecture composites

    International Nuclear Information System (INIS)

    Highlights: ► Composite design inspired by nature. ► Tuning microstructure via changing ceramic content and aspect ratio. ► Experimental display of structure–property correlationship in synthetic composites. - Abstract: Structural biocomposites (for example, nacre in seashells, bone, etc.) are designed according to the functional role they are delegated for. For instance, bone is primarily designed for withstanding time-dependent loading (for example, withstanding stresses while running, jumping, accidental fall) and hence the microstructure is designed primarily from enhanced toughness and moderate stiffness point of view. On the contrary, seashells (which lie in the abyss of oceans) apart from providing defense to the organism (it is hosting) against predatory attacks, are subjected to static loading (for example, enormous hydrostatic pressure). Hence, emphasis on the shell structure evolution is directed primarily towards providing enhanced stiffness. In order to conform between stiffness and toughness, nature precisely employs a staggered arrangement of inorganic bricks in a biopolymer matrix (at its most elementary level of architecture). Aspect ratio and content of ceramic bricks are meticulously used by nature to synthesize composites having varying degrees of stiffness, strength and toughness. Such an amazing capability of structure–property correlationship has rarely been demonstrated in synthetic composites. Therefore, in order to better understand the mechanical behavior of synthetic staggered composites, the problem becomes two-pronged: (a) synthesize composites with varying brick size and contents and (b) experimental investigation of the material response. In this article, an attempt has been made to synthesize and characterize staggered ceramic–polymer composites having varying aspect ratio and ceramic content using freeze-casting technique. This will in-turn help us in custom-design manufacture of hybrid bio-inspired composite materials

  5. The Mothership Mission Architecture

    Science.gov (United States)

    Ernst, S. M.; DiCorcia, J. D.; Bonin, G.; Gump, D.; Lewis, J. S.; Foulds, C.; Faber, D.

    2015-12-01

    The Mothership is considered to be a dedicated deep space carrier spacecraft. It is currently being developed by Deep Space Industries (DSI) as a mission concept that enables a broad participation in the scientific exploration of small bodies - the Mothership mission architecture. A Mothership shall deliver third-party nano-sats, experiments and instruments to Near Earth Asteroids (NEOs), comets or moons. The Mothership service includes delivery of nano-sats, communication to Earth and visuals of the asteroid surface and surrounding area. The Mothership is designed to carry about 10 nano-sats, based upon a variation of the Cubesat standard, with some flexibility on the specific geometry. The Deep Space Nano-Sat reference design is a 14.5 cm cube, which accommodates the same volume as a traditional 3U CubeSat. To reduce cost, Mothership is designed as a secondary payload aboard launches to GTO. DSI is offering slots for nano-sats to individual customers. This enables organizations with relatively low operating budgets to closely examine an asteroid with highly specialized sensors of their own choosing and carry out experiments in the proximity of or on the surface of an asteroid, while the nano-sats can be built or commissioned by a variety of smaller institutions, companies, or agencies. While the overall Mothership mission will have a financial volume somewhere between a European Space Agencies' (ESA) S- and M-class mission for instance, it can be funded through a number of small and individual funding sources and programs, hence avoiding the processes associated with traditional space exploration missions. DSI has been able to identify a significant interest in the planetary science and nano-satellite communities.

  6. Architecture of WEST plasma control system

    International Nuclear Information System (INIS)

    To operate advanced plasma scenario (long pulse with high stored energy) in present and future tokamak devices under safe operation conditions, the control requirements of the plasma control system (PCS) leads to the development of advanced feedback control and real time handling exceptions. To develop these controllers and these exceptions handling strategies, a project aiming at setting up a flight simulator has started at CEA in 2009. Now, the new WEST (W Environment in Steady-state Tokamak) project deals with modifying Tore Supra into an ITER-like divertor tokamak. This upgrade impacts a lot of systems including Tore Supra PCS and is the opportunity to improve the current PCS architecture to implement the previous works and to fulfill the needs of modern tokamak operation. This paper is dealing with the description of the architecture of WEST PCS. Firstly, the requirements will be presented including the needs of new concepts (segments configuration, alternative (or backup) scenario, …). Then, the conceptual design of the PCS will be described including the main components and their functions. The third part will be dedicated to the proposal RT framework and to the technologies that we have to implement to reach the requirements

  7. A Software Architecture for Intelligent Synthesis Environments

    Science.gov (United States)

    Filman, Robert E.; Norvig, Peter (Technical Monitor)

    2001-01-01

    The NASA's Intelligent Synthesis Environment (ISE) program is a grand attempt to develop a system to transform the way complex artifacts are engineered. This paper discusses a "middleware" architecture for enabling the development of ISE. Desirable elements of such an Intelligent Synthesis Architecture (ISA) include remote invocation; plug-and-play applications; scripting of applications; management of design artifacts, tools, and artifact and tool attributes; common system services; system management; and systematic enforcement of policies. This paper argues that the ISA extend conventional distributed object technology (DOT) such as CORBA and Product Data Managers with flexible repositories of product and tool annotations and "plug-and-play" mechanisms for inserting "ility" or orthogonal concerns into the system. I describe the Object Infrastructure Framework, an Aspect Oriented Programming (AOP) environment for developing distributed systems that provides utility insertion and enables consistent annotation maintenance. This technology can be used to enforce policies such as maintaining the annotations of artifacts, particularly the provenance and access control rules of artifacts-, performing automatic datatype transformations between representations; supplying alternative servers of the same service; reporting on the status of jobs and the system; conveying privileges throughout an application; supporting long-lived transactions; maintaining version consistency; and providing software redundancy and mobility.

  8. Architecture, eTrees, & Nature

    Directory of Open Access Journals (Sweden)

    Dennis Dollens

    2010-06-01

    Full Text Available One vision for grafting biological performance into buildings includes inventing, growing, and synthesizing biological attributes for architectural life—thinking of architecture as metabolically evolved nature/culture. This requires a parallel strategy fostering collaborations between design, biology, art, horticulture, e-plant simulation, synthetic life, bio-mineralization, and advanced fabrication. It encourages designers to integrate industrial and agricultural information as design research with the goal of embedding specific environmental-life responses in architecture. This text discusses and illustrates induced evolution in one emerging method for design realized through software simulation—in this case, plant-to-architecture generation based in naturally occurring algorithms, found for example, in botanic phyllotaxy and allometry.

  9. Performative Architecture and Urban Spaces

    DEFF Research Database (Denmark)

    Kiib, Hans

    2008-01-01

    Exibition follow the content of tree workshops Workshop 1: Digital architecture - Copenhagen Group This workshop focus on digital methods and representation of architecture and urban environments. On the basis of selected parameters it developed a new transparent spaces of interaction and new architectural...... workshop focus on temporary architecture and urban catalysts. Informal spaces and the interface between the built and the void are foremost in the development of performative urban environments and cultural interaction. ...... Aalborg. They took as its departure one of the sub-themes of the assignment and develop it within the present context of Aalborg. It is our intention to develop new types of open learning environments and public domains as well as places of experiment and uncertainty. The Format of the Workshops The...

  10. Transverse pumped laser amplifier architecture

    Science.gov (United States)

    Bayramian, Andrew James; Manes, Kenneth; Deri, Robert; Erlandson, Al; Caird, John; Spaeth, Mary

    2013-07-09

    An optical gain architecture includes a pump source and a pump aperture. The architecture also includes a gain region including a gain element operable to amplify light at a laser wavelength. The gain region is characterized by a first side intersecting an optical path, a second side opposing the first side, a third side adjacent the first and second sides, and a fourth side opposing the third side. The architecture further includes a dichroic section disposed between the pump aperture and the first side of the gain region. The dichroic section is characterized by low reflectance at a pump wavelength and high reflectance at the laser wavelength. The architecture additionally includes a first cladding section proximate to the third side of the gain region and a second cladding section proximate to the fourth side of the gain region.

  11. Architectural Qualities in Passive Houses

    DEFF Research Database (Denmark)

    Brunsgaard, Camilla

    2012-01-01

    In recent years in Denmark there has been an increasing focus on implementing passive and active strategies in buildings to fulfil low energy demands like for example the Passive House Standard. From a technical rational perspective, plenty of pilot projects and commercial projects have shown that...... it is possible to build this type of houses, but the knowledge and discussion about the architectural quality in the buildings is hardly present. The question is if the strategies for optimising energy use and indoor environment collide with the architectural qualities of buildings. This paper brings...... forth this discussion based in literature and four case studies. The paper highlights cases on how passive strategies for optimising energy use and indoor environment affect, restrict, inspire or create possibilities for the architectural expression and there through the architectural quality of the...

  12. Role of outer membrane architecture in immune evasion by Treponema pallidum and Borrelia burgdorferi.

    Science.gov (United States)

    Radolf, J D

    1994-09-01

    Combined ultrastructural and molecular studies have revealed that the syphilis and Lyme-disease spirochetes, Treponema pallidum and Borrelia burgdorferi, have distinctive molecular architectures. Both organisms persist in their hosts and have strategies for immune evasion that include the use of rare, poorly immunogenic surface-exposed proteins as potential virulence determinants. PMID:7812663

  13. Architecture from quantity to quality

    OpenAIRE

    Luca Gibello

    2015-01-01

    Having surpassed the problem of quantity, it is necessary to now address the problem of widespread quality where we have ensured, that all land surface areas be defined by an architecture project, or rather in a holistic, integrated and multidisciplinary approach. The objective then, is know how to intervene in the scope of transformation, revitalization, reconversion and reuse in urban design. Architecture must know the ‘catalogs’ that provide best practice for design processes and products,...

  14. Exploration of Heterogeneous FPGA Architectures

    Directory of Open Access Journals (Sweden)

    Umer Farooq

    2011-01-01

    mesh and tree-based architectures are evaluated for three sets of benchmark circuits. Experimental results show that a more flexible floor-planning in mesh-based FPGA gives better results as compared to the column-based floor-planning. Also it is shown that compared to different floor-plannings of mesh-based FPGA, tree-based architecture gives better area, performance, and power results.

  15. Security for service oriented architectures

    CERN Document Server

    Williams, Walter

    2014-01-01

    Although integrating security into the design of applications has proven to deliver resilient products, there are few books available that provide guidance on how to incorporate security into the design of an application. Filling this need, Security for Service Oriented Architectures examines both application and security architectures and illustrates the relationship between the two. Supplying authoritative guidance on how to design distributed and resilient applications, the book provides an overview of the various standards that service oriented and distributed applications leverage, includ

  16. Architectural heritage conservation in China

    OpenAIRE

    Zheng, Qilin; 郑琪琳

    2011-01-01

    As a contribution to econometric research on the role of architectural heritage, this dissertation evaluates non-aggregate data for a total of 2142 designated National Priority Protected Sites (NPPS) in China using hedonic model and ordered probit model. Attempting to verify economic costs of conserving architectural heritage sites in China, the objectives of the dissertation are to find out the grading system of NPPS; to compare the monetary value and non-monetary value methods on architectu...

  17. A safety licensable computing architecture

    CERN Document Server

    Halang, WA; Jung, S-K; Scheepstra, JJ

    1993-01-01

    This book describes the design of a low complexity, fault-detecting computer architecture for utilisation in programmable logic controllers (PLCs) for process control purposes. The cyclic operating mode of PLCs and a specification level graphical programming paradigm based on interconnecting application-oriented standard software function modules are architecturally supported. Thus, by design, there is no semantic gap between the specification, programming and machine execution levels enabling the safety licensing of application software by diverse back translation, an extremely simple but rig

  18. Cell Architecture for Nanoelectronic Design

    OpenAIRE

    Martorell, F.; A. Rubio

    2007-01-01

    Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/5920) International audience Several nanoelectronic devices have been already proved. However, no architecture which makes use of them provides a feasible opportunity to build medium/large systems. Nanoarchitecture proposals only solve a small part of the problems needed to achieve a real design. In this paper, we propose and analyze a cell architecture that overcomes most of those at the gate level. ...

  19. Classifying Enterprise Architecture Analysis Approaches

    Science.gov (United States)

    Buckl, Sabine; Matthes, Florian; Schweda, Christian M.

    Enterprise architecture (EA) management forms a commonly accepted means to enhance the alignment of business and IT, and to support the managed evolution of the enterprise. One major challenge of EA management is to provide decision support by analyzing as-is states of the architecture as well as assessing planned future states. Thus, different kinds of analysis regarding the EA exist, each relying on certain conditions and demands for models, methods, and techniques.

  20. Model Driven ArchitectureTM

    CERN Document Server

    Frankel, David S

    2003-01-01

    Model Driven Architecture MDA)is a new methodologyf rom OMG that uses modeling languages like UML along with programming languages like Java to build software architectures. PriceWatersCoopers' prestigious Technology Center just predicted that MDA will be one of the most important methodologies in the next two years Written by the lead architect of the specification who provides inside information on how MDA has worked in the real world